                         SEQUENCE LISTING

<110>  THE UNIVERSITY OF BRITISH COLUMBIA

<120>  MODULATION OF CYP8B1 FOR THE PRESERVATION AND TREATMENT OF LIVER 
       FIBROSIS AND METABOLIC DISORDERS

<130>  P1462PC00

<140>  WO PCT/CA2016/000181
<141>  2016-06-29

<150>  US 62/185,885
<151>  2015-06-29

<160>  109   

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  phosphorothioate modification

<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<400>  1
gctcacttcc acccactccc                                                   20

<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  phosphorothioate modification

<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<400>  2
ttcatctcgc tgagggcaaa                                                   20

<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  3
atgggctgtg atcggaactg                                                   20

<210>  4
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  4
gtcttcccaa taagcatgtc tcc                                               23

<210>  5
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  5
acagttggca caatagacgt tt                                                22

<210>  6
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  6
ccttccattt cagtgttgca ga                                                22

<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  7
ggaggtggtg atagccggta t                                                 21

<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  8
tgggtaatcc atagagccca g                                                 21

<210>  9
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  9
ttcttgcgat acactctggt gc                                                22

<210>  10
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  10
cgggattgaa tgttcttgtc gt                                                22

<210>  11
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  11
gctcctctta ggggccact                                                    19

<210>  12
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  12
ccacgtctca ccattgggg                                                    19

<210>  13
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  13
ctgtaacatg gaaactgggg aaa                                               23

<210>  14
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  14
ccatagctga actgaaaacc acc                                               23

<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  15
gcaactcgga cctggtcata a                                                 21

<210>  16
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  16
cggcccgtga tgagaaact                                                    19

<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  17
tcagagccaa agcagtgagc                                                   20

<210>  18
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  18
gccgtgtaga taaactcgat gtc                                               23

<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  19
gtcccagaca tcagggagta a                                                 21

<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  20
tcggatactt cagcgtcagg a                                                 21

<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  21
gacgtggaac tggcagaaga g                                                 21

<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  22
ttggtggttt gtgagtgtga g                                                 21

<210>  23
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  23
atgaacgcta cacactgcat c                                                 21

<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  24
ccatcctttt gccagttcct c                                                 21

<210>  25
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  25
gcaactgttc ctgaactcaa ct                                                22

<210>  26
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  26
atcttttggg gtccgtcaac t                                                 21

<210>  27
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  27
tagtccttcc taccccaatt tcc                                               23

<210>  28
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  28
ttggtcctta gccactcctt c                                                 21

<210>  29
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  29
tctgactcag tgattcttcg ca                                                22

<210>  30
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  30
cccataaaca tcagccagtt gt                                                22

<210>  31
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  31
tgggtcccaa ggagtatgc                                                    19

<210>  32
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  32
gctccaagac ttcacacagt g                                                 21

<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  33
atggggtctc ggttcttcct                                                   20

<210>  34
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  34
gtcttctggt acaggtcttt gg                                                22

<210>  35
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  35
ctgacaggat gcctagccg                                                    19

<210>  36
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  36
cgcaggtaat cccagaagc                                                    19

<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  37
cagcagtcag tgtgcttaca a                                                 21


<210>  38
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  38
atggctcttt tatcggcctc a                                                 21

<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  39
cgcaaagggc cacttttact a                                                 21

<210>  40
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  40
gcccccatca tataagaacc ag                                                22

<210>  41
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  41
atgggaaatc ccctccaaat ct                                                22

<210>  42
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  42
gtgctgaggt ctgagacga                                                    19

<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  43
gggagtggct agaagtgggc                                                   20

<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  44
tttgcactca gtgaggtgaa                                                   20

<210>  45
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  45
ctgaagcacc cagaagctat t                                                 21

<210>  46
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  46
aatagcttct gggtgcttca g                                                 21

<210>  47
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  47
aattcaaaca tattcttccg g                                                 21

<210>  48
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  48
ggaagaatat gtttgaattt c                                                 21

<210>  49
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  49
agtttttttg catattgccc a                                                 21

<210>  50
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  50
ggcaatatgc aaaaaaactg g                                                 21

<210>  51
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  51
ttgaagaagt ccactttccg g                                                 21

<210>  52
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  52
ggaaagtgga cttcttcaag a                                                 21

<210>  53
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  53
tgggagcccc ctctggacaa gggt                                              24

<210>  54
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  54
acccttgtcc agagggggct ccca                                              24

<210>  55
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  55
ggttggttca tgaagactat accct                                             25

<210>  56
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  56
agggtatagt cttcatgaac caacc                                             25

<210>  57
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  57
cggaagaata tgtttgaatt tct                                               23

<210>  58
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  58
tgggcaatat gcaaaaaaac tgg                                               23

<210>  59
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  59
aatgagacca tgctggacag cct                                               23

<210>  60
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  60
ccgcaagttt gaccttcttt tcc                                               23

<210>  61
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  61
gggcaacatg cttcagtttc tga                                               23

<210>  62
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  62
aggacaagtt caacttcatg atg                                               23

<210>  63
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  63
gccctcttgt acctcctgaa gca                                               23

<210>  64
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  64
ctcctcaggt tggttcatga aga                                               23

<210>  65
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  65
aagactatac cctgaagatg tcc                                               23

<210>  66
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  66
tcatgaagac tataccctga aga                                               23

<210>  67
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  67
ccggaaagtg gacttcttca aga                                               23

<210>  68
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  68
gtgaagctct ttatcctgct tat                                               23

<210>  69
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  69
cacacacttt gacttagagt tgg                                               23

<210>  70
<211>  27
<212>  DNA
<213>  Artificial Sequence


<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Optionally deoxy nucleotides

<400>  70
agtgctggga gctctgctgg tggtcat                                           27

<210>  71
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Optionally deoxy nucleotides

<400>  71
atgccatggc tttccggaag aatatgt                                           27

<210>  72
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Optionally deoxy nucleotides

<400>  72
cgtcatggac cccctctcct ttggctc                                           27

<210>  73
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Optionally deoxy nucleotides

<400>  73
actttgggca atatgcaaaa aaactgg                                           27

<210>  74
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Optionally deoxy nucleotides

<400>  74
atggcttgaa ggatcttaat gagacca                                           27

<210>  75
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Optionally deoxy nucleotides

<400>  75
aatgagacca tgctggacag cctgtcc                                           27

<210>  76
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Optionally deoxy nucleotides

<400>  76
tggagttccg caagtttgac cttcttt                                           27

<210>  77
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Optionally deoxy nucleotides

<400>  77
acatgcttca gtttctgagg gagcagg                                           27

<210>  78
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Optionally deoxy nucleotides

<400>  78
accctcagct atgcaggaca agttcaa                                           27

<210>  79
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Optionally deoxy nucleotides

<400>  79
ctcttgtacc tcctgaagca cccagaa                                           27

<210>  80
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Optionally deoxy nucleotides

<400>  80
ctgcggctga gggctgcacc caccctc                                           27

<210>  81
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Optionally deoxy nucleotides

<400>  81
gaagactata ccctgaagat gtccagt                                           27

<210>  82
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Optionally deoxy nucleotides

<400>  82
atggcagccg gaaagtggac ttcttca                                           27

<210>  83
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Optionally deoxy nucleotides

<400>  83
tccactacac catgccctgg ggttcgg                                           27

<210>  84
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Optionally deoxy nucleotides

<400>  84
tgaagctctt tatcctgctt atggtcac                                          28

<210>  85
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Optionally deoxy nucleotides

<400>  85
gacttagagt tggtggaccc tgacaca                                           27

<210>  86
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<220>
<221>  misc_feature
<222>  (5)..(10)
<223>  phosphorothioate modification

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<400>  86
tccagtgctg ggag                                                         14

<210>  87
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<220>
<221>  misc_feature
<222>  (5)..(10)
<223>  phosphorothioate modification

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<400>  87
ccggaagaat atgt                                                         14

<210>  88
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<220>
<221>  misc_feature
<222>  (5)..(10)
<223>  phosphorothioate modification

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<400>  88
acagagaaaa ctag                                                         14

<210>  89
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<220>
<221>  misc_feature
<222>  (5)..(10)
<223>  phosphorothioate modification

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<400>  89
atggcttgaa ggat                                                         14


<210>  90
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<220>
<221>  misc_feature
<222>  (5)..(10)
<223>  phosphorothioate modification

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<400>  90
atgctggaca gcct                                                         14

<210>  91
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<220>
<221>  misc_feature
<222>  (5)..(10)
<223>  phosphorothioate modification

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<400>  91
tggagttccg caag                                                         14

<210>  92
<211>  14
<212>  DNA
<213>  Artificial Sequence


<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<220>
<221>  misc_feature
<222>  (5)..(10)
<223>  phosphorothioate modification

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<400>  92
tctgagggag cagg                                                         14

<210>  93
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<220>
<221>  misc_feature
<222>  (5)..(10)
<223>  phosphorothioate modification

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<400>  93
cagctatgca ggac                                                         14

<210>  94
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<220>
<221>  misc_feature
<222>  (5)..(10)
<223>  phosphorothioate modification

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<400>  94
gttcaacttc atga                                                         14

<210>  95
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<220>
<221>  misc_feature
<222>  (5)..(10)
<223>  phosphorothioate modification

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<400>  95
ttgtacctcc tgaa                                                         14

<210>  96
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<220>
<221>  misc_feature
<222>  (5)..(10)
<223>  phosphorothioate modification

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<400>  96
agaagctatt cggg                                                         14

<210>  97
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<220>
<221>  misc_feature
<222>  (5)..(10)
<223>  phosphorothioate modification

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<400>  97
ggctgagggc tgca                                                         14


<210>  98
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<220>
<221>  misc_feature
<222>  (5)..(10)
<223>  phosphorothioate modification

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<400>  98
tcctcaggtt ggtt                                                         14

<210>  99
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<220>
<221>  misc_feature
<222>  (5)..(10)
<223>  phosphorothioate modification

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<400>  99
actataccct gaag                                                         14

<210>  100
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<220>
<221>  misc_feature
<222>  (5)..(10)
<223>  phosphorothioate modification

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<400>  100
aaagtggact tctt                                                         14

<210>  101
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<220>
<221>  misc_feature
<222>  (5)..(10)
<223>  phosphorothioate modification

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<400>  101
tacaccatgc cctg                                                         14

<210>  102
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<220>
<221>  misc_feature
<222>  (5)..(10)
<223>  phosphorothioate modification

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<400>  102
tgaagctctt tatc                                                         14

<210>  103
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<220>
<221>  misc_feature
<222>  (5)..(10)
<223>  phosphorothioate modification

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  Locked Nucleic Acid - the ribose ring is connected by a methylene
       bridge between the 2'-O and 4'-C atoms

<400>  103
acttagagtt ggtg                                                         14

<210>  104
<211>  1506
<212>  DNA
<213>  Homo sapiens

<400>  104
atggttctct ggggtccagt gctgggagct ctgctggtgg tcattgctgg atacctgtgc       60
ctgccaggga tgctccgaca acgcaggcca tgggagcccc ctctggacaa gggtaccgtg      120
ccctggcttg gccatgccat ggctttccgg aagaatatgt ttgaatttct gaagcgcatg      180
aggaccaagc atggggatgt gttcacagtg cagctagggg gccagtactt caccttcgtc      240
atggaccccc tctcctttgg ctccatcctc aaggacacac agagaaaact agactttggg      300
caatatgcaa aaaaactggt gctgaaggta tttggatacc gttcagtgca aggggaccat      360
gagatgatac actcagccag caccaagcat ctgagggggg atggcttgaa ggatcttaat      420
gagaccatgc tggacagcct gtcctttgta atgctgacgt ccaaaggctg gagtctggat      480
gccagttgct ggcatgagga cagcctcttt cgcttctgct attacatctt gttcacagct      540
ggctacctga gcttgttcgg ctacacgaag gacaaggagc aggacctgct acaggcagga      600
gagttattca tggagttccg caagtttgac cttcttttcc caaggtttgt ctactccctg      660
ctgtggcccc gggagtggct agaagtgggc cgactccagc gtctctttca caagatgctc      720
tccgtgagcc acagccagga gaaggagggc atcagcaact ggctgggcaa catgcttcag      780
tttctgaggg agcagggggt accctcagct atgcaggaca agttcaactt catgatgctc      840
tgggcctccc aggggaacac ggggcctacc tctttctggg ccctcttgta cctcctgaag      900
cacccagaag ctattcgggc tgtgagggag gaagctaccc aggtcctggg tgaggccagg      960
ctggagacca agcagtcctt tgccttcaaa ctcggtgccc tgcaacacac cccagttcta     1020
gacagcgtgg tggaggagac gctgcggctg agggctgcac ccaccctcct caggttggtt     1080
catgaagact ataccctgaa gatgtccagt gggcaggagt atctgttccg ccatggagac     1140
atcctggccc tctttcccta cctctcagtg cacatggacc ctgacatcca ccctgagccc     1200
accgtcttca agtacgatcg cttcctcaac cctaatggca gccggaaagt ggacttcttc     1260
aagacaggca agaagatcca ccactacacc atgccctggg gttcgggcgt ttccatctgc     1320
cctgggaggt tctttgcact cagtgaggtg aagctcttta tcctgcttat ggtcacacac     1380
tttgacttag agttggtgga ccctgacaca ccactacccc atgttgaccc gcagcgctgg     1440
ggttttggca ccatgcagcc cagccacgat gtgcgcttcc gctaccgcct gcatcctaca     1500
gagtga                                                                1506

<210>  105
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  105
gctcacttcc acccactccc                                                   20

<210>  106
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  106
ttcatctcgc tgagggcaaa                                                   20

<210>  107
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  107
atctcgctga gggca                                                        15

<210>  108
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  108
aacacgtcta tacgc                                                        15

<210>  109
<211>  1506
<212>  RNA
<213>  Homo sapiens

<400>  109
augguucucu gggguccagu gcugggagcu cugcuggugg ucauugcugg auaccugugc       60
cugccaggga ugcuccgaca acgcaggcca ugggagcccc cucuggacaa ggguaccgug      120
cccuggcuug gccaugccau ggcuuuccgg aagaauaugu uugaauuucu gaagcgcaug      180
aggaccaagc auggggaugu guucacagug cagcuagggg gccaguacuu caccuucguc      240
auggaccccc ucuccuuugg cuccauccuc aaggacacac agagaaaacu agacuuuggg      300
caauaugcaa aaaaacuggu gcugaaggua uuuggauacc guucagugca aggggaccau      360
gagaugauac acucagccag caccaagcau cugagggggg auggcuugaa ggaucuuaau      420
gagaccaugc uggacagccu guccuuugua augcugacgu ccaaaggcug gagucuggau      480
gccaguugcu ggcaugagga cagccucuuu cgcuucugcu auuacaucuu guucacagcu      540
ggcuaccuga gcuuguucgg cuacacgaag gacaaggagc aggaccugcu acaggcagga      600
gaguuauuca uggaguuccg caaguuugac cuucuuuucc caagguuugu cuacucccug      660
cuguggcccc gggaguggcu agaagugggc cgacuccagc gucucuuuca caagaugcuc      720
uccgugagcc acagccagga gaaggagggc aucagcaacu ggcugggcaa caugcuucag      780
uuucugaggg agcagggggu acccucagcu augcaggaca aguucaacuu caugaugcuc      840
ugggccuccc aggggaacac ggggccuacc ucuuucuggg cccucuugua ccuccugaag      900
cacccagaag cuauucgggc ugugagggag gaagcuaccc agguccuggg ugaggccagg      960
cuggagacca agcaguccuu ugccuucaaa cucggugccc ugcaacacac cccaguucua     1020
gacagcgugg uggaggagac gcugcggcug agggcugcac ccacccuccu cagguugguu     1080
caugaagacu auacccugaa gauguccagu gggcaggagu aucuguuccg ccauggagac     1140
auccuggccc ucuuucccua ccucucagug cacauggacc cugacaucca cccugagccc     1200
accgucuuca aguacgaucg cuuccucaac ccuaauggca gccggaaagu ggacuucuuc     1260
aagacaggca agaagaucca ccacuacacc augcccuggg guucgggcgu uuccaucugc     1320
ccugggaggu ucuuugcacu cagugaggug aagcucuuua uccugcuuau ggucacacac     1380
uuugacuuag aguuggugga cccugacaca ccacuacccc auguugaccc gcagcgcugg     1440
gguuuuggca ccaugcagcc cagccacgau gugcgcuucc gcuaccgccu gcauccuaca     1500
gaguga                                                                1506