                         SEQUENCE LISTING

<110>  UCB BIOPHARMA sprl
 
<120>  Tau-binding antibodies

<130>  PF0031-WO-PCT

<160>  65    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1

<400>  1

Gln Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2

<400>  2

Ala Ala Ser Tyr Leu Ala Ser 
1               5           


<210>  3
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be A or G

<400>  3

Gln Gln Xaa Tyr Thr Arg Thr Asp Ile Asp Asn Thr 
1               5                   10          


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1

<400>  4

Gly Ile Asp Leu Ser Thr Trp Arg Met Asn 
1               5                   10  


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  5

Ile Ile Gly Thr Gly Gly Arg Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 
1               5                   10                  15      


<210>  6
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be A, Q, N, D or S

<400>  6

Leu Gly Ala Asn Asn Xaa Gly Tyr Pro Leu Asp Leu 
1               5                   10          


<210>  7
<211>  110
<212>  PRT
<213>  Rabbit


<220>
<221>  MISC_FEATURE
<222>  (91)..(91)
<223>  Xaa can be A or G

<400>  7

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Tyr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Xaa Tyr Thr Arg Thr Asp 
                85                  90                  95      


Ile Asp Asn Thr Phe Gly Gly Gly Thr Lys Val Val Val Glu 
            100                 105                 110 


<210>  8
<211>  117
<212>  PRT
<213>  Rabbit


<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  Xaa can be A, Q, N, D or S

<400>  8

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Thr Trp Arg 
            20                  25                  30          


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Gly Thr Gly Gly Arg Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Val Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Leu Gly 
                85                  90                  95      


Ala Asn Asn Xaa Gly Tyr Pro Leu Asp Leu Trp Gly Pro Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser
        115     


<210>  9
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murinised

<400>  9

Asp Val Val Met Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Gln Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Tyr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Asn Ile His Pro Val Glu Glu 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Arg Thr Asp 
                85                  90                  95      


Ile Asp Asn Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110 


<210>  10
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murinised

<400>  10

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Thr Trp 
            20                  25                  30          


Arg Met Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Gly Thr Gly Gly Arg Thr Tyr Tyr Ala Asn Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Lys Asp Ser Thr Gln Val Phe Leu Lys Met 
65                  70                  75                  80  


Asn Ser Leu Gln Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Leu 
                85                  90                  95      


Gly Ala Asn Asn Asn Gly Tyr Pro Leu Asp Leu Trp Gly Ala Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser
        115         


<210>  11
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Tyr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Arg Thr Asp 
                85                  90                  95      


Ile Asp Asn Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  12
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Tyr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Thr Arg Thr Asp 
                85                  90                  95      


Ile Asp Asn Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  13
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized


<220>
<221>  MISC_FEATURE
<222>  (91)..(91)
<223>  Xaa can be A or G

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Tyr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Xaa Tyr Thr Arg Thr Asp 
                85                  90                  95      


Ile Asp Asn Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  14
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  14

Glu Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Thr Trp 
            20                  25                  30          


Arg Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Gly Thr Gly Gly Arg Thr Tyr Tyr Ala Asn Trp Ala Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Gly Ala Asn Asn Gln Gly Tyr Pro Leu Asp Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser
        115                 120    


<210>  15
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  15

Glu Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Thr Trp 
            20                  25                  30          


Arg Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Gly Thr Gly Gly Arg Thr Tyr Tyr Ala Asn Trp Ala Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Gly Ala Asn Asn Ala Gly Tyr Pro Leu Asp Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser
        115                 120


<210>  16
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized


<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  Xaa can be  A, Q, N, D or S

<400>  16

Glu Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Thr Trp 
            20                  25                  30          


Arg Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Gly Thr Gly Gly Arg Thr Tyr Tyr Ala Asn Trp Ala Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Gly Ala Asn Asn Xaa Gly Tyr Pro Leu Asp Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser
        115                 120


<210>  17
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Tyr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Arg Thr Asp 
                85                  90                  95      


Ile Asp Asn Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  18
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  18

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Tyr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Thr Arg Thr Asp 
                85                  90                  95      


Ile Asp Asn Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  19
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized


<220>
<221>  MISC_FEATURE
<222>  (91)..(91)
<223>  Xaa can be A or G

<400>  19

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Tyr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Xaa Tyr Thr Arg Thr Asp 
                85                  90                  95      


Ile Asp Asn Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  20
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  20

Glu Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Thr Trp 
            20                  25                  30          


Arg Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Gly Thr Gly Gly Arg Thr Tyr Tyr Ala Asn Trp Ala Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Gly Ala Asn Asn Gln Gly Tyr Pro Leu Asp Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  21
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  21

Glu Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Thr Trp 
            20                  25                  30          


Arg Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Gly Thr Gly Gly Arg Thr Tyr Tyr Ala Asn Trp Ala Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Gly Ala Asn Asn Ala Gly Tyr Pro Leu Asp Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  22
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized


<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  Xaa can be  A, Q, N, D or S

<400>  22

Glu Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Thr Trp 
            20                  25                  30          


Arg Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Gly Thr Gly Gly Arg Thr Tyr Tyr Ala Asn Trp Ala Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Gly Ala Asn Asn Xaa Gly Tyr Pro Leu Asp Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  23
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  23

Glu Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Thr Trp 
            20                  25                  30          


Arg Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Gly Thr Gly Gly Arg Thr Tyr Tyr Ala Asn Trp Ala Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Gly Ala Asn Asn Gln Gly Tyr Pro Leu Asp Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  24
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  24

Glu Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Thr Trp 
            20                  25                  30          


Arg Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Gly Thr Gly Gly Arg Thr Tyr Tyr Ala Asn Trp Ala Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Gly Ala Asn Asn Ala Gly Tyr Pro Leu Asp Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  25
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized


<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  Xaa can be A, Q, N, D or S

<400>  25

Glu Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Thr Trp 
            20                  25                  30          


Arg Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Gly Thr Gly Gly Arg Thr Tyr Tyr Ala Asn Trp Ala Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Gly Ala Asn Asn Xaa Gly Tyr Pro Leu Asp Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  26
<211>  330
<212>  DNA
<213>  Rabbit

<400>  26
gatgttgtga tgacccagac tccagcctcc gtggaggcag ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtca gagcgttagt agttacttag cctggtatca gcagaaacca      120

gggcagcctc ccaagctcct gatctatgct gcatcctatc tggcatccgg ggtcccatca      180

cggttcaaag gcagtggatc tgggacagag ttcactctca ccatcagcga cctggagtgt      240

gccgatgctg ccacttatta ctgtcaacag ggttatacta ggactgatat tgataatact      300

ttcggcggag ggaccaaggt ggtggtcgaa                                       330


<210>  27
<211>  351
<212>  DNA
<213>  Rabbit

<400>  27
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggaatcga cctcagtact tggagaatga actgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggaatcatt ggtactggtg gtagaacata ctacgcgaac      180

tgggcaaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaggtcacc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gattgggtgc taataataat      300

ggttatcctt tggacttgtg gggcccgggg accctggtca ccgtctcgag t               351


<210>  28
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  murinised

<400>  28
gatgtcgtga tgactcagtc acccgcaagc ctggctgtgt cgctgggaca gcgggctact       60

atctcgtgcc aagcgtccca gtctgtctcc tcgtacttgg cctggtatca gcagaagcca      120

ggacagccgc cgaaactcct catctacgcc gcctcatacc ttgcgtccgg agtgccttcg      180

agattcaaag gaagcggaag cggcactgag tttaccctga acatccaccc ggtggaagaa      240

gaggacgcag ccacgtacta ctgtcaacaa gggtacaccc gcaccgatat tgacaatacc      300

ttcggtggcg ggactaagct ggaaatcaag                                       330


<210>  29
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  murinised

<400>  29
caagtgcagc tgaaagaatc aggaccggga ctggtggcac caagccagtc cctgtcgatc       60

acctgtactg tgtccggaat cgacctctcc acctggcgca tgaattgggt ccggcagcct      120

cccggaaagg gcctcgaatg gattggcatc atcggtactg ggggcagaac ttactacgcc      180

aattgggcga aggggcgctt ctcaatctcg aaagactcga cccaagtgtt cttgaagatg      240

aacagccttc agaccgagga taccgctacc tacttttgcg cgaggctggg agccaacaac      300

aacggttacc cgctcgatct gtggggagcc ggaacgactg tgactgtctc gagc            354


<210>  30
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  30
gatatccaaa tgacccagtc cccatcctcc ctgtccgctt ctgtcggtga ccgcgtgacc       60

attacttgtc aagccagcca gtcggtgtcc tcatacctcg cctggtatca gcagaagccg      120

ggaaaggcgc ccaaactttt gatctacgcc gcctcgtacc tggcatccgg cgtgccgtca      180

agattcagcg ggtcgggctc cggaactgac ttcaccctga ccatcagcag cctgcagcct      240

gaggactttg ccacttacta ctgccagcag ggatacaccc ggaccgatat tgacaacacc      300

ttcggcgggg gaactaaggt cgaaatcaag                                       330


<210>  31
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  31
gatatccaaa tgacccagtc cccatcctcc ctgtccgctt ctgtcggtga ccgcgtgacc       60

attacttgtc aagccagcca gtcggtgtcc tcatacctcg cctggtatca gcagaagccg      120

ggaaaggcgc ccaaactttt gatctacgcc gcctcgtacc tggcatccgg cgtgccgtca      180

agattcagcg ggtcgggctc cggaactgac ttcaccctga ccatcagcag cctgcagcct      240

gaggactttg ccacttacta ctgccagcag gcctacaccc ggaccgatat tgacaacacc      300

ttcggcgggg gaactaaggt cgaaatcaag                                       330


<210>  32
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  32
gagctccaac tgcaagaatc cggccctggt ctggtcaagc cctccgaaac cctgagcctc       60

acctgtactg tgtccgggat cgacttgagc acctggagga tgaactggat tcgccagcca      120

ccgggaaagg gactggagtg gatcggcatt atcggtactg ggggacggac ctactacgcc      180

aattgggcaa agggcagagt gacgatttca aaggacacct cgaagaacca ggtgtccctg      240

aaactgtcct ccgtgactgc ggctgacacc gccgtgtact attgcgcccg gctgggagcc      300

aacaaccagg gctacccgct ggatctttgg ggacagggaa ccctcgtgac tgtctcgagt      360


<210>  33
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  33
gagctccaac tgcaagaatc cggccctggt ctggtcaagc cctccgaaac cctgagcctc       60

acctgtactg tgtccgggat cgacttgagc acctggagga tgaactggat tcgccagcca      120

ccgggaaagg gactggagtg gatcggcatt atcggtactg ggggacggac ctactacgcc      180

aattgggcaa agggcagagt gacgatttca aaggacacct cgaagaacca ggtgtccctg      240

aaactgtcct ccgtgactgc ggctgacacc gccgtgtact attgcgcccg gctgggagcc      300

aacaacgccg gctacccgct ggatctttgg ggacagggaa ccctcgtgac tgtctcgagt      360


<210>  34
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  34
gatatccaaa tgacccagtc cccatcctcc ctgtccgctt ctgtcggtga ccgcgtgacc       60

attacttgtc aagccagcca gtcggtgtcc tcatacctcg cctggtatca gcagaagccg      120

ggaaaggcgc ccaaactttt gatctacgcc gcctcgtacc tggcatccgg cgtgccgtca      180

agattcagcg ggtcgggctc cggaactgac ttcaccctga ccatcagcag cctgcagcct      240

gaggactttg ccacttacta ctgccagcag ggatacaccc ggaccgatat tgacaacacc      300

ttcggcgggg gaactaaggt cgaaatcaag cggaccgtgg ccgctccctc cgtgttcatc      360

ttcccaccct ccgacgagca gcttaagtcc ggcaccgcct ccgtcgtgtg cctgctgaac      420

aacttctacc cccgcgaggc caaggtgcag tggaaggtgg acaacgccct gcagtccggc      480

aactcccagg aatccgtcac cgagcaggac tccaaggaca gcacctactc cctgtcctcc      540

accctgaccc tgtccaaggc cgactacgag aagcacaagg tgtacgcctg cgaagtgacc      600

caccagggcc tgtccagccc cgtgaccaag tccttcaacc ggggcgagtg c               651


<210>  35
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  35
gatatccaaa tgacccagtc cccatcctcc ctgtccgctt ctgtcggtga ccgcgtgacc       60

attacttgtc aagccagcca gtcggtgtcc tcatacctcg cctggtatca gcagaagccg      120

ggaaaggcgc ccaaactttt gatctacgcc gcctcgtacc tggcatccgg cgtgccgtca      180

agattcagcg ggtcgggctc cggaactgac ttcaccctga ccatcagcag cctgcagcct      240

gaggactttg ccacttacta ctgccagcag gcctacaccc ggaccgatat tgacaacacc      300

ttcggcgggg gaactaaggt cgaaatcaag cgtacggtag cggccccatc tgtcttcatc      360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t               651


<210>  36
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  36
gagctccaac tgcaagaatc cggccctggt ctggtcaagc cctccgaaac cctgagcctc       60

acctgtactg tgtccgggat cgacttgagc acctggagga tgaactggat tcgccagcca      120

ccgggaaagg gactggagtg gatcggcatt atcggtactg ggggacggac ctactacgcc      180

aattgggcaa agggcagagt gacgatttca aaggacacct cgaagaacca ggtgtccctg      240

aaactgtcct ccgtgactgc ggctgacacc gccgtgtact attgcgcccg gctgggagcc      300

aacaaccagg gctacccgct ggatctttgg ggacagggaa ccctcgtgac tgtctcgagt      360

gcctccacca agggcccctc cgtgttccct ctggcccctt gctcccggtc cacctccgag      420

tctaccgccg ctctgggctg cctggtcaag gactacttcc ccgagcccgt gacagtgtcc      480

tggaactctg gcgccctgac ctccggcgtg cacaccttcc ctgccgtgct gcagtcctcc      540

ggcctgtact ccctgtcctc cgtcgtgacc gtgccctcct ccagcctggg caccaagacc      600

tacacctgta acgtggacca caagccctcc aacaccaagg tggacaagcg ggtggaatct      660

aagtacggcc ctccctgccc cccctgccct gcccctgaat ttctgggcgg accttccgtg      720

ttcctgttcc ccccaaagcc caaggacacc ctgatgatct cccggacccc cgaagtgacc      780

tgcgtggtgg tggacgtgtc ccaggaagat cccgaggtcc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaatgc caagaccaag cccagagagg aacagttcaa ctccacctac      900

cgggtggtgt ccgtgctgac cgtgctgcac caggactggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccctcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagcccc gcgagcccca ggtgtacacc ctgcccccta gccaggaaga gatgaccaag     1080

aaccaggtgt ccctgacctg tctggtcaag ggcttctacc cctccgacat tgccgtggaa     1140

tgggagtcca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc     1200

gacggctcct tcttcctgta ctctcggctg accgtggaca agtcccggtg gcaggaaggc     1260

aacgtcttct cctgctccgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1320

ctgtccctga gcctgggcaa g                                               1341


<210>  37
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  37
gagctccaac tgcaagaatc cggccctggt ctggtcaagc cctccgaaac cctgagcctc       60

acctgtactg tgtccgggat cgacttgagc acctggagga tgaactggat tcgccagcca      120

ccgggaaagg gactggagtg gatcggcatt atcggtactg ggggacggac ctactacgcc      180

aattgggcaa agggcagagt gacgatttca aaggacacct cgaagaacca ggtgtccctg      240

aaactgtcct ccgtgactgc ggctgacacc gccgtgtact attgcgcccg gctgggagcc      300

aacaacgccg gctacccgct ggatctttgg ggacagggaa ccctcgtgac tgtctcgagt      360

gcctccacca agggcccctc cgtgttccct ctggcccctt gctcccggtc cacctccgag      420

tctaccgccg ctctgggctg cctggtcaag gactacttcc ccgagcccgt gacagtgtcc      480

tggaactctg gcgccctgac ctccggcgtg cacaccttcc ctgccgtgct gcagtcctcc      540

ggcctgtact ccctgtcctc cgtcgtgacc gtgccctcct ccagcctggg caccaagacc      600

tacacctgta acgtggacca caagccctcc aacaccaagg tggacaagcg ggtggaatct      660

aagtacggcc ctccctgccc cccctgccct gcccctgaat ttctgggcgg accttccgtg      720

ttcctgttcc ccccaaagcc caaggacacc ctgatgatct cccggacccc cgaagtgacc      780

tgcgtggtgg tggacgtgtc ccaggaagat cccgaggtcc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaatgc caagaccaag cccagagagg aacagttcaa ctccacctac      900

cgggtggtgt ccgtgctgac cgtgctgcac caggactggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgccctcc agcatcgaaa agaccatctc caaggccaag     1020

ggccagcccc gcgagcccca ggtgtacacc ctgcccccta gccaggaaga gatgaccaag     1080

aaccaggtgt ccctgacctg tctggtcaag ggcttctacc cctccgacat tgccgtggaa     1140

tgggagtcca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc     1200

gacggctcct tcttcctgta ctctcggctg accgtggaca agtcccggtg gcaggaaggc     1260

aacgtcttct cctgctccgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1320

ctgtccctga gcctgggcaa g                                               1341


<210>  38
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  38
gagctccaac tgcaagaatc cggccctggt ctggtcaagc cctccgaaac cctgagcctc       60

acctgtactg tgtccgggat cgacttgagc acctggagga tgaactggat tcgccagcca      120

ccgggaaagg gactggagtg gatcggcatt atcggtactg ggggacggac ctactacgcc      180

aattgggcaa agggcagagt gacgatttca aaggacacct cgaagaacca ggtgtccctg      240

aaactgtcct ccgtgactgc ggctgacacc gccgtgtact attgcgcccg gctgggagcc      300

aacaaccagg gctacccgct ggatctttgg ggacagggaa ccctcgtgac tgtctcgagt      360

gcctccacca agggcccctc cgtgttcccg ctcgctccat catcgaagtc taccagcgga      420

ggcactgcgg ctctcggttg cctcgtgaag gactacttcc cggagccggt gaccgtgtcg      480

tggaacagcg gagccctgac cagcggggtg cacacctttc cggccgtctt gcagtcaagc      540

ggcctttact ccctgtcatc agtggtgact gtcccgtcca gctcattggg aacccaaacc      600

tacatctgca atgtgaatca caaacctagc aacaccaagg ttgacaagaa agtcgagccc      660

aaatcgtgtg acaagactca cacttgtccg ccgtgcccgg cacccgaact gctgggaggt      720

cccagcgtct ttctgttccc tccaaagccg aaagacacgc tgatgatctc ccgcaccccg      780

gaggtcactt gcgtggtcgt ggacgtgtca catgaggacc cagaggtgaa gttcaattgg      840

tacgtggatg gcgtcgaagt ccacaatgcc aaaactaagc ccagagaaga acagtacaat      900

tcgacctacc gcgtcgtgtc cgtgctcacg gtgttgcatc aggattggct gaacgggaag      960

gaatacaagt gcaaagtgtc caacaaggcg ctgccggcac cgatcgagaa aactatctcc     1020

aaagcgaagg gacagcctag ggaacctcaa gtctacacgc tgccaccatc acgggatgaa     1080

ctgactaaga atcaagtctc actgacttgt ctggtgaagg ggttttaccc tagcgacatt     1140

gccgtggagt gggaatccaa cggccagcca gagaacaact acaagactac ccctccagtg     1200

ctcgactcgg atggatcgtt cttcctttac tcgaagctca ccgtggataa gtcccggtgg     1260

cagcagggaa acgtgttctc ctgctcggtg atgcatgaag ccctccataa ccactatacc     1320

caaaagtcgc tgtccctgtc gccgggaaag                                      1350


<210>  39
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  39
gagctccaac tgcaagaatc cggccctggt ctggtcaagc cctccgaaac cctgagcctc       60

acctgtactg tgtccgggat cgacttgagc acctggagga tgaactggat tcgccagcca      120

ccgggaaagg gactggagtg gatcggcatt atcggtactg ggggacggac ctactacgcc      180

aattgggcaa agggcagagt gacgatttca aaggacacct cgaagaacca ggtgtccctg      240

aaactgtcct ccgtgactgc ggctgacacc gccgtgtact attgcgcccg gctgggagcc      300

aacaacgccg gctacccgct ggatctttgg ggacagggaa ccctcgtgac tgtctcgagt      360

gcctccacca agggcccctc cgtgttcccg ctcgctccat catcgaagtc taccagcgga      420

ggcactgcgg ctctcggttg cctcgtgaag gactacttcc cggagccggt gaccgtgtcg      480

tggaacagcg gagccctgac cagcggggtg cacacctttc cggccgtctt gcagtcaagc      540

ggcctttact ccctgtcatc agtggtgact gtcccgtcca gctcattggg aacccaaacc      600

tacatctgca atgtgaatca caaacctagc aacaccaagg ttgacaagaa agtcgagccc      660

aaatcgtgtg acaagactca cacttgtccg ccgtgcccgg cacccgaact gctgggaggt      720

cccagcgtct ttctgttccc tccaaagccg aaagacacgc tgatgatctc ccgcaccccg      780

gaggtcactt gcgtggtcgt ggacgtgtca catgaggacc cagaggtgaa gttcaattgg      840

tacgtggatg gcgtcgaagt ccacaatgcc aaaactaagc ccagagaaga acagtacaat      900

tcgacctacc gcgtcgtgtc cgtgctcacg gtgttgcatc aggattggct gaacgggaag      960

gaatacaagt gcaaagtgtc caacaaggcg ctgccggcac cgatcgagaa aactatctcc     1020

aaagcgaagg gacagcctag ggaacctcaa gtctacacgc tgccaccatc acgggatgaa     1080

ctgactaaga atcaagtctc actgacttgt ctggtgaagg ggttttaccc tagcgacatt     1140

gccgtggagt gggaatccaa cggccagcca gagaacaact acaagactac ccctccagtg     1200

ctcgactcgg atggatcgtt cttcctttac tcgaagctca ccgtggataa gtcccggtgg     1260

cagcagggaa acgtgttctc ctgctcggtg atgcatgaag ccctccataa ccactatacc     1320

caaaagtcgc tgtccctgtc gccgggaaag                                      1350


<210>  40
<211>  132
<212>  PRT
<213>  Rabbit


<220>
<221>  MISC_FEATURE
<222>  (1)..(22)
<223>  Signal sequence

<400>  40

Met Asp Met Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys Asp Val Val Met Thr Gln Thr Pro Ala Ser 
            20                  25                  30          


Val Glu Ala Ala Val Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser 
        35                  40                  45              


Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Pro Pro Lys Leu Leu Ile Tyr Ala Ala Ser Tyr Leu Ala Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Gly Tyr Thr Arg Thr Asp Ile Asp Asn Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Val Val Val Glu 
    130         


<210>  41
<211>  136
<212>  PRT
<213>  Rabbit


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Signal sequence

<400>  41

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 
            20                  25                  30          


Gly Thr Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser 
        35                  40                  45              


Thr Trp Arg Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Ile Ile Gly Thr Gly Gly Arg Thr Tyr Tyr Ala Asn Trp 
65                  70                  75                  80  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu 
                85                  90                  95      


Lys Val Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
            100                 105                 110         


Arg Leu Gly Ala Asn Asn Asn Gly Tyr Pro Leu Asp Leu Trp Gly Pro 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser
    130                 135 


<210>  42
<211>  396
<212>  DNA
<213>  Rabbit


<220>
<221>  misc_feature
<222>  (1)..(66)
<223>  Signal sequence

<400>  42
atggacatga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc       60

agatgtgatg ttgtgatgac ccagactcca gcctccgtgg aggcagctgt gggaggcaca      120

gtcaccatca agtgccaggc cagtcagagc gttagtagtt acttagcctg gtatcagcag      180

aaaccagggc agcctcccaa gctcctgatc tatgctgcat cctatctggc atccggggtc      240

ccatcacggt tcaaaggcag tggatctggg acagagttca ctctcaccat cagcgacctg      300

gagtgtgccg atgctgccac ttattactgt caacagggtt atactaggac tgatattgat      360

aatactttcg gcggagggac caaggtggtg gtcgaa                                396


<210>  43
<211>  408
<212>  DNA
<213>  Rabbit


<220>
<221>  misc_feature
<222>  (1)..(57)
<223>  Signal sequence

<400>  43
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag       60

tcgctggagg agtccggggg tcgcctggtc acgcctggga cacccctgac actcacctgc      120

acagtctctg gaatcgacct cagtacttgg agaatgaact gggtccgcca ggctccaggg      180

aaggggctgg aatggatcgg aatcattggt actggtggta gaacatacta cgcgaactgg      240

gcaaaaggcc gattcaccat ctccaaaacc tcgaccacgg tggatctgaa ggtcaccagt      300

ccgacaaccg aggacacggc cacctatttc tgtgccagat tgggtgctaa taataatggt      360

tatcctttgg acttgtgggg cccggggacc ctggtcaccg tctcgagt                   408


<210>  44
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  44

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  45
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  45

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser
    


<210>  46
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  46
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  47
<211>  342
<212>  DNA
<213>  Homo sapiens

<400>  47
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtagtagtt actactgggg ctggatccgc      120

cagcccccag ggaaggggct ggagtggatt gggagtatct attatagtgg gagcacctac      180

tacaacccgt ccctcaagag tcgagtcacc atatccgtag acacgtccaa gaaccagttc      240

tccctgaagc tgagctctgt gaccgccgca gacacggctg tgtattactg tgcgagatac      300

tttgactact ggggccaagg aaccctggtc accgtctcct ca                         342


<210>  48
<211>  12
<212>  PRT
<213>  Rabbit

<400>  48

Leu Gly Ala Asn Asn Asn Gly Tyr Pro Leu Asp Leu 
1               5                   10          


<210>  49
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  49

Leu Gly Ala Asn Asn Gln Gly Tyr Pro Leu Asp Leu 
1               5                   10          


<210>  50
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  50

Leu Gly Ala Asn Asn Ala Gly Tyr Pro Leu Asp Leu 
1               5                   10          


<210>  51
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  51

Leu Gly Ala Asn Asn Asp Gly Tyr Pro Leu Asp Leu 
1               5                   10          


<210>  52
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  52

Leu Gly Ala Asn Asn Ser Gly Tyr Pro Leu Asp Leu 
1               5                   10          


<210>  53
<211>  12
<212>  PRT
<213>  Rabbit

<400>  53

Gln Gln Gly Tyr Thr Arg Thr Asp Ile Asp Asn Thr 
1               5                   10          


<210>  54
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized

<400>  54

Gln Gln Ala Tyr Thr Arg Thr Asp Ile Asp Asn Thr 
1               5                   10          


<210>  55
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        275                 280                 285             


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    290                 295                 300                 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
305                 310                 315                 320 


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
                325                 330                 335     


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
            340                 345                 350         


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
        355                 360                 365             


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
    370                 375                 380                 


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
385                 390                 395                 400 


Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
                405                 410                 415     


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            420                 425                 430         


Ser Ala Ser Leu Ala Lys Gln Gly Leu 
        435                 440     


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  ACETYLATION and NYTROSYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  NYTROSYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  PHOSPHORYLATION

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  PHOSPHORYLATION

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Position of Biotin Conjugation

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  PHOSPHORYLATION

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  PHOSPHORYLATION

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  AMIDATION

<400>  56

Tyr Ser Ser Pro Cys Ser Pro Gly Thr Pro 
1               5                   10  


<210>  57
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  PHOSPHORYLATION

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  PHOSPHORYLATION

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  PHOSPHORYLATION

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Position of Biotin Conjugation

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  AMIDATION

<400>  57

Arg Thr Pro Pro Lys Ser Pro Ser Ser Cys 
1               5                   10  


<210>  58
<211>  217
<212>  PRT
<213>  Mouse

<400>  58

Asp Val Val Met Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Gln Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Tyr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Asn Ile His Pro Val Glu Glu 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Arg Thr Asp 
                85                  90                  95      


Ile Asp Asn Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 110         


Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu 
        115                 120                 125             


Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn 
145                 150                 155                 160 


Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His 
            180                 185                 190         


Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile 
        195                 200                 205             


Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215         


<210>  59
<211>  442
<212>  PRT
<213>  Mouse

<400>  59

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Thr Trp 
            20                  25                  30          


Arg Met Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Gly Thr Gly Gly Arg Thr Tyr Tyr Ala Asn Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Lys Asp Ser Thr Gln Val Phe Leu Lys Met 
65                  70                  75                  80  


Asn Ser Leu Gln Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Leu 
                85                  90                  95      


Gly Ala Asn Asn Asn Gly Tyr Pro Leu Asp Leu Trp Gly Ala Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro 
        115                 120                 125             


Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn 
145                 150                 155                 160 


Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr 
            180                 185                 190         


Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro 
    210                 215                 220                 


Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp 
            260                 265                 270         


Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser 
305                 310                 315                 320 


Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
                325                 330                 335     


Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln 
            340                 345                 350         


Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe 
        355                 360                 365             


Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu 
    370                 375                 380                 


Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe 
385                 390                 395                 400 


Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn 
                405                 410                 415     


Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr 
            420                 425                 430         


Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440         


<210>  60
<211>  651
<212>  DNA
<213>  Mouse

<400>  60
gatgtcgtga tgactcagtc acccgcaagc ctggctgtgt cgctgggaca gcgggctact       60

atctcgtgcc aagcgtccca gtctgtctcc tcgtacttgg cctggtatca gcagaagcca      120

ggacagccgc cgaaactcct catctacgcc gcctcatacc ttgcgtccgg agtgccttcg      180

agattcaaag gaagcggaag cggcactgag tttaccctga acatccaccc ggtggaagaa      240

gaggacgcag ccacgtacta ctgtcaacaa gggtacaccc gcaccgatat tgacaatacc      300

ttcggtggcg ggactaagct ggaaatcaag cgtacggatg ctgcaccaac tgtatccatc      360

ttcccaccat ccagtgagca gttaacatct ggaggtgcct cagtcgtgtg cttcttgaac      420

aacttctacc ccaaagacat caatgtcaag tggaagattg atggcagtga acgacaaaat      480

ggcgtcctga acagttggac tgatcaggac agcaaagaca gcacctacag catgagcagc      540

accctcacgt tgaccaagga cgagtatgaa cgacataaca gctatacctg tgaggccact      600

cacaagacat caacttcacc cattgtcaag agcttcaaca ggaatgagtg t               651


<210>  61
<211>  1326
<212>  DNA
<213>  Mouse

<400>  61
caagtgcagc tgaaagaatc aggaccggga ctggtggcac caagccagtc cctgtcgatc       60

acctgtactg tgtccggaat cgacctctcc acctggcgca tgaattgggt ccggcagcct      120

cccggaaagg gcctcgaatg gattggcatc atcggtactg ggggcagaac ttactacgcc      180

aattgggcga aggggcgctt ctcaatctcg aaagactcga cccaagtgtt cttgaagatg      240

aacagccttc agaccgagga taccgctacc tacttttgcg cgaggctggg agccaacaac      300

aacggttacc cgctcgatct gtggggagcc ggaacgactg tgactgtctc gagtgccaaa      360

acgacacccc catctgtcta tccactggcc cctggatctg ctgcccaaac taactccatg      420

gtgaccctgg gatgcctggt caagggctat ttccctgagc cagtgacagt gacctggaac      480

tctggatccc tgtccagcgg tgtgcacacc ttcccagctg tcctgcagtc tgacctctac      540

actctgagca gctcagtgac tgtcccctcc agcacctggc ccagcgagac cgtcacctgc      600

aacgttgccc acccggccag cagcaccaag gtggacaaga aaattgtgcc cagggattgt      660

ggttgtaagc cttgcatatg tacagtccca gaagtatcat ctgtcttcat cttcccccca      720

aagcccaagg atgtgctcac cattactctg actcctaagg tcacgtgtgt tgtggtagac      780

atcagcaagg atgatcccga ggtccagttc agctggtttg tagatgatgt ggaggtgcac      840

acagctcaga cgcaaccccg ggaggagcag ttcaacagca ctttccgctc agtcagtgaa      900

cttcccatca tgcaccagga ctggctcaat ggcaaggagt tcaaatgcag ggtcaacagt      960

gcagctttcc ctgcccccat cgagaaaacc atctccaaaa ccaaaggcag accgaaggct     1020

ccacaggtgt acaccattcc acctcccaag gagcagatgg ccaaggataa agtcagtctg     1080

acctgcatga taacagactt cttccctgaa gacattactg tggagtggca gtggaatggg     1140

cagccagcgg agaactacaa gaacactcag cccatcatgg acacagatgg ctcttacttc     1200

gtctacagca agctcaatgt gcagaagagc aactgggagg caggaaatac tttcacctgc     1260

tctgtgttac atgagggcct gcacaaccac catactgaga agagcctctc ccactctcct     1320

ggtaaa                                                                1326


<210>  62
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Position of Biotin Conjugation

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  PHOSPHORYLATION

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  PHOSPHORYLATION

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  AMIDATION

<400>  62

Cys Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro 
1               5                   10      


<210>  63
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  PHOSPHORYLATION

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  PHOSPHORYLATION

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  PHOSPHORYLATION

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Position of Biotin Conjugation

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  AMIDATION

<400>  63

Arg Thr Pro Ser Leu Pro Thr Pro Cys 
1               5                   


<210>  64
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Position of Biotin Conjugation

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  PHOSPHORYLATION

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  PHOSPHORYLATION

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  PHOSPHORYLATION

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  PHOSPHORYLATION

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  AMIDATION

<400>  64

Cys Ser Pro Val Val Ser Gly Asp Thr Ser 
1               5                   10  


<210>  65
<211>  10
<212>  PRT
<213>  Artificial Sequence

<400>  65

Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro 
1               5                   10  

