                         SEQUENCE LISTING

<110>  Lucas, Alexandra Rose
 
<120>  Compositions and Methods for Reducing Organ Rejection By Reducing
        Heparan Sulfate in Donor Transplants

<130>  21011.0053P1

<150>  62/189,548
<151>  2015-07-07

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  1

Met Asp Gly Arg Leu Val Phe Leu Leu Ala Ser Leu Ala Ile Val Ser 
1               5                   10                  15      


Asp Ala Val Arg Leu Thr Ser Tyr Asp Leu Asn Thr Phe Val Thr Trp 
            20                  25                  30          


Gln Asp Asp Gly Tyr Thr Tyr Asn Val Ser Ile Lys Pro Tyr Thr Thr 
        35                  40                  45              


Ala Thr Trp Ile Asn Val Cys Glu Trp Ala Ser Ser Ser Cys Asn Val 
    50                  55                  60                  


Ser Leu Ala Leu Gln Tyr Asp Leu Asp Val Val Ser Trp Ala Arg Leu 
65                  70                  75                  80  


Thr Arg Val Gly Lys Tyr Thr Glu Tyr Ser Leu Glu Pro Thr Cys Ala 
                85                  90                  95      


Val Ala Arg Phe Ser Pro Pro Glu Val Gln Leu Val Arg Thr Gly Thr 
            100                 105                 110         


Ser Val Glu Val Leu Val Arg His Pro Val Val Tyr Leu Arg Gly Gln 
        115                 120                 125             


Glu Val Ser Val Tyr Gly His Ser Phe Cys Asp Tyr Asp Phe Gly Tyr 
    130                 135                 140                 


Lys Thr Ile Phe Leu Phe Ser Lys Asn Lys Arg Ala Glu Tyr Val Val 
145                 150                 155                 160 


Pro Gly Arg Tyr Cys Asp Asn Val Glu Cys Arg Phe Ser Ile Asp Ser 
                165                 170                 175     


Gln Glu Ser Val Cys Ala Thr Ala Val Leu Thr Tyr Asp Gly Ser Tyr 
            180                 185                 190         


Arg Ser Glu Ala Gly Val Glu Val Cys Val Pro Glu Leu Ala Lys Arg 
        195                 200                 205             


Glu Val Ser Pro Tyr Ile Val Lys Lys Ser Ser Asp Leu Glu Tyr Val 
    210                 215                 220                 


Lys Arg Ala Ile His Asn Glu Tyr Arg Leu Asp Thr Ser Ser Glu Gly 
225                 230                 235                 240 


Arg Arg Leu Glu Glu Leu Tyr Leu Thr Val Ala Ser Met Phe Glu Arg 
                245                 250                 255     


Leu Val Glu Asp Val Phe Glu 
            260             


<210>  2
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2

Met Asp Gly Arg Leu Val Phe Leu Leu Ala Ser Leu Ala Ile Val Ser 
1               5                   10                  15      


Asp Ala Val Arg Leu Thr Ser Tyr Asp Leu Asn Thr Phe Val Thr Trp 
            20                  25                  30          


Gln Asp Asp Gly Tyr Thr Tyr Asn Val Ser Ile Lys Pro Tyr Thr Thr 
        35                  40                  45              


Ala Thr Trp Ile Asn Val Cys Glu Trp Ala Ser Ser Ser Cys Asn Val 
    50                  55                  60                  


Ser Leu Ala Leu Gln Tyr Asp Leu Asp Val Val Ser Trp Ala Arg Leu 
65                  70                  75                  80  


Thr Arg Val Gly Lys Tyr Thr Glu Tyr Ser Leu Glu Pro Thr Cys Ala 
                85                  90                  95      


Val Ala Arg Phe Ser Pro Pro Glu Val Gln Leu Val Arg Thr Gly Thr 
            100                 105                 110         


Ser Val Glu Val Leu Val Arg His Pro Val Val Tyr Leu Arg Gly Gln 
        115                 120                 125             


Glu Val Ser Val Tyr Gly His Ser Phe Cys Asp Tyr Asp Phe Gly Tyr 
    130                 135                 140                 


Lys Thr Ile Phe Leu Phe Ser Lys Asn Lys Arg Ala Glu Tyr Val Val 
145                 150                 155                 160 


Pro Gly Arg Tyr Cys Asp Asn Val Glu Cys Glu Phe Ser Ile Asp Ser 
                165                 170                 175     


Gln Glu Ser Val Cys Ala Thr Ala Val Leu Thr Tyr Asp Gly Ser Tyr 
            180                 185                 190         


Arg Ser Glu Ala Gly Val Glu Val Cys Val Pro Glu Leu Ala Lys Arg 
        195                 200                 205             


Glu Val Ser Pro Tyr Ile Val Lys Lys Ser Ser Asp Leu Glu Tyr Val 
    210                 215                 220                 


Lys Arg Ala Ile His Asn Glu Tyr Arg Leu Asp Thr Ser Ser Glu Gly 
225                 230                 235                 240 


Arg Arg Leu Glu Glu Leu Tyr Leu Thr Val Ala Ser Met Phe Glu Arg 
                245                 250                 255     


Leu Val Glu Asp Val Phe Glu 
            260             


<210>  3
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3

Met Asp Gly Arg Leu Val Phe Leu Leu Ala Ser Leu Ala Ile Val Ser 
1               5                   10                  15      


Asp Ala Val Arg Leu Thr Ser Tyr Asp Leu Asn Thr Phe Val Thr Trp 
            20                  25                  30          


Gln Asp Asp Gly Tyr Thr Tyr Asn Val Ser Ile Lys Pro Tyr Thr Thr 
        35                  40                  45              


Ala Thr Trp Ile Asn Val Cys Glu Trp Ala Ser Ser Ser Cys Asn Val 
    50                  55                  60                  


Ser Leu Ala Leu Gln Tyr Asp Leu Asp Val Val Ser Trp Ala Arg Leu 
65                  70                  75                  80  


Thr Arg Val Gly Lys Tyr Thr Glu Tyr Ser Leu Glu Pro Thr Cys Ala 
                85                  90                  95      


Val Ala Arg Phe Ser Pro Pro Glu Val Gln Leu Val Arg Thr Gly Thr 
            100                 105                 110         


Ser Val Glu Val Leu Val Arg His Pro Val Val Tyr Leu Arg Gly Gln 
        115                 120                 125             


Glu Val Ser Val Tyr Gly His Ser Phe Cys Asp Tyr Asp Phe Gly Tyr 
    130                 135                 140                 


Lys Thr Ile Phe Leu Phe Ser Lys Asn Lys Arg Ala Glu Tyr Val Val 
145                 150                 155                 160 


Pro Gly Arg Tyr Cys Asp Asn Val Glu Cys Arg Phe Ser Ile Asp Ser 
                165                 170                 175     


Gln Glu Ser Val Cys Ala Thr Ala Val Leu Thr Tyr Asp Gly Ser Tyr 
            180                 185                 190         


Arg Ser Glu Ala Gly Val Glu Val Cys Val Pro Glu Leu Ala Lys Arg 
        195                 200                 205             


Ile Val Ser Pro Tyr Ile Val Lys Lys Ser Ser Asp Leu Glu Tyr Val 
    210                 215                 220                 


Lys Arg Ala Ile His Asn Glu Tyr Arg Leu Asp Thr Ser Ser Glu Gly 
225                 230                 235                 240 


Arg Arg Leu Glu Glu Leu Tyr Leu Thr Val Ala Ser Met Phe Glu Arg 
                245                 250                 255     


Leu Val Glu Asp Val Phe Glu 
            260             


<210>  4
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4

Met Asp Gly Arg Leu Val Phe Leu Leu Ala Ser Leu Ala Ile Val Ser 
1               5                   10                  15      


Asp Ala Val Arg Leu Thr Ser Tyr Asp Leu Asn Thr Phe Val Thr Trp 
            20                  25                  30          


Gln Asp Asp Gly Tyr Thr Tyr Asn Val Ser Ile Lys Pro Tyr Thr Thr 
        35                  40                  45              


Ala Thr Trp Ile Asn Val Cys Glu Trp Ala Ser Ser Ser Cys Asn Val 
    50                  55                  60                  


Ser Leu Ala Leu Gln Tyr Asp Leu Asp Val Val Ser Trp Ala Arg Leu 
65                  70                  75                  80  


Thr Arg Val Gly Lys Tyr Thr Glu Tyr Ser Leu Glu Pro Thr Cys Ala 
                85                  90                  95      


Val Ala Arg Phe Ser Pro Pro Glu Val Gln Leu Val Arg Thr Gly Thr 
            100                 105                 110         


Ser Val Glu Val Leu Val Arg His Pro Val Val Tyr Leu Arg Gly Gln 
        115                 120                 125             


Glu Val Ser Val Tyr Gly His Ser Asp Cys Asp Tyr Asp Phe Gly Tyr 
    130                 135                 140                 


Lys Thr Ile Phe Leu Phe Ser Lys Asn Lys Arg Ala Glu Tyr Val Val 
145                 150                 155                 160 


Pro Gly Arg Tyr Cys Asp Asn Val Glu Cys Arg Phe Ser Ile Asp Ser 
                165                 170                 175     


Gln Glu Ser Val Cys Ala Thr Ala Val Leu Thr Tyr Asp Gly Ser Tyr 
            180                 185                 190         


Arg Ser Glu Ala Gly Val Glu Val Cys Val Pro Glu Leu Ala Lys Arg 
        195                 200                 205             


Glu Val Ser Pro Tyr Ile Val Lys Lys Ser Ser Asp Leu Glu Tyr Val 
    210                 215                 220                 


Lys Arg Ala Ile His Asn Glu Tyr Arg Leu Asp Thr Ser Ser Glu Gly 
225                 230                 235                 240 


Arg Arg Leu Glu Glu Leu Tyr Leu Thr Val Ala Ser Met Phe Glu Arg 
                245                 250                 255     


Leu Val Glu Asp Val Phe Glu 
            260             


