               SEQUENCE LISTING

<110> Apogenix AG

<120> Method of predicting the responsiveness of a cancer disease to treatment

<130> 60622P WO

<160> 12

<170> BiSSAP 1.3.5

<210> 1
<211> 400
<212> PRT
<213> Artificial Sequence

<223> Recombinant fusion protein consisting of human CD95 extracellular domain with human IgG1 FC-part to its C-terminus

<220> 
<221> SIGNAL
<222> 1..16
<223> Variable cleavage sites

<220> 
<221> SIGNAL
<222> 1..20
<223> Variable cleavage sites

<220> 
<221> SIGNAL
<222> 1..25
<223> Variable cleavage sites

<220> 
<223> Recombinant fusion protein consisting of human CD95 extracellular
      domain with human IgG1 FC-part to its C-terminus

<220> 
<221> MOD_RES
<222> 26..26
<223> PYRROLIDONE CARBOXYLIC ACID

<220> 
<221> DOMAIN
<222> 26..172
<223> Human CD95 extracellular domain

<220> 
<221> DISULFID
<222> 59..73

<220> 
<221> DISULFID
<222> 63..82

<220> 
<221> DISULFID
<222> 85..101

<220> 
<221> DISULFID
<222> 104..119

<220> 
<221> DISULFID
<222> 107..127

<220> 
<221> CARBOHYD
<222> 118..118
<223> N-linked Glycosylation at Position N118

<220> 
<221> DISULFID
<222> 129..143

<220> 
<221> DISULFID
<222> 135..140

<220> 
<221> CARBOHYD
<222> 136..136
<223> N-linked Glycosylation at Position N136

<220> 
<221> DISULFID
<222> 146..157

<220> 
<221> DISULFID
<222> 149..165

<220> 
<221> DOMAIN
<222> 172..400
<223> Human IgG1-FC domain (one amino acid overlap with CD95 domain)

<220> 
<221> DISULFID
<222> 173..173
<223> Interchain cystine forming residue.

<220> 
<221> DISULFID
<222> 179..179
<223> Interchain cystine forming residue.

<220> 
<221> DISULFID
<222> 182..182
<223> Interchain cystine forming residue

<220> 
<221> DISULFID
<222> 214..274

<220> 
<221> CARBOHYD
<222> 250..250
<223> N-linked Glycosylation at Position N250

<220> 
<221> DISULFID
<222> 320..378

<400> 1
Met Val Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      
Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          
Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              
Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  
Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  
Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      
Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 
            100                 105                 110         
Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 
        115                 120                 125             
Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 
    130                 135                 140                 
Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 
145                 150                 155                 160 
Ser Asn Thr Lys Cys Lys Glu Glu Gly Ser Arg Ser Cys Asp Lys Thr 
                165                 170                 175     
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            180                 185                 190         
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        195                 200                 205             
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    210                 215                 220                 
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
225                 230                 235                 240 
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                245                 250                 255     
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            260                 265                 270         
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        275                 280                 285             
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    290                 295                 300                 
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
305                 310                 315                 320 
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                325                 330                 335     
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            340                 345                 350         
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        355                 360                 365             
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    370                 375                 380                 
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
385                 390                 395                 400 



<210> 2
<211> 1560
<212> DNA
<213> Homo sapiens


<220> 
<221> misc_feature
<222> 354..354
<223> /note="SNP, cytosine may be thymine"

<220> 
<221> misc_feature
<222> 354..355
<223> /note="CpG5"

<220> 
<221> misc_feature
<222> 876..877
<223> /note="cg10161121, CpG2"

<220> 
<221> 5'UTR
<222> 1041..1041

<220> 
<221> misc_feature
<222> 1198..1200
<223> /note="Startcodon"

<400> 2
ggtcagttgg gctcagtgca gtggctcatg cctgtaattc cagcactttg ggaaactgag      60

gcaggaggat gtcttgaagc taggagtttg agacaagcct gggcaacata gcaagtcccc     120

atctgtacaa aaaaaaaaaa gaataaatta gtcaggtgta gtgacttatg cctataatcc     180

cagctactca ggaggccaag gcaagaggat tgcttgagcc caggagtttg aggctgcagt     240

taactacgat agcaccactg cactccagcc tgggtgacag agtgagactc tgtctctatt     300

taaataaata agtaaataaa taaactgggc aaacaatgaa aatgaaaaca ttgcgaaata     360

caaagcagct ctgtgggttc cactggtttg cagcctctga tctaatttct aaagtgggtg     420

tagcaggttt ttaacctgta aattatggtg atcggcaggt cagggtaaat ggtagttgtg     480

tgtggggaag agatgatggc aacagatgtt ttcctcctgc aaaaactaaa atgtgggagt     540

gacttctctg gccatgactc catggtctct cccctcagag ccattttcag taaaattttt     600

atagtttaaa aaatacggtt ctgaacaatt tttgttagag ttattttggg atttttaaat     660

agttttttgg ttgtgtatat ggtagaattc ttaaaattat acaattataa tgtataaaaa     720

agcatgcaat tataattcat aaaattatag ccccactgac cattctcctg tagctgggag     780

cagttcacac taacagggct atacccccat gctgacctgc tctgcaggat cccaggaagg     840

tgagcatagc ctactaacct gtttgggtag cacagcgaca gcaactgagg ccttgaaggc     900

tgttatcaga aaattgtggg cggaaacttc caggggtttg ctctgagctt cttgaggctt     960

ctcagcttca gctgcaaagt gagtgggtgt ttctttgaga agcagaatca gagagagaga    1020

gatagagaaa gagaaagaca gaggtgtttc ccttagctat ggaaactcta taagagagat    1080

ccagcttgcc tcctcttgag cagtcagcaa cagggtcccg tccttgacac ctcagcctct    1140

acaggactga gaagaagtaa aaccgtttgc tggggctggc ctgactcacc agctgccatg    1200

cagcagccct tcaattaccc atatccccag atctactggg tggacagcag tgccagctct    1260

ccctgggccc ctccaggcac agttcttccc tgtccaacct ctgtgcccag aaggcctggt    1320

caaaggaggc caccaccacc accgccaccg ccaccactac cacctccgcc gccgccgcca    1380

ccactgcctc cactaccgct gccacccctg aagaagagag ggaaccacag cacaggcctg    1440

tgtctccttg tgatgttttt catggttctg gttgccttgg taggattggg cctggggatg    1500

tttcagctct tccacctaca gaaggagctg gcagaactcc gagaggtaag cctgccggca    1560


<210> 3
<211> 26
<212> DNA
<213> Artificial Sequence

<223> "PCR Primer"

<220> 
<223> PCR Primer

<400> 3
tttgtaggat tttaggaagg tgagta                                         26


<210> 4
<211> 22
<212> DNA
<213> Artificial Sequence

<223> "PCR Primer"

<220> 
<223> PCR Primer

<400> 4
aaaaatttcc acccacaatt tt                                             22


<210> 5
<211> 28
<212> DNA
<213> Artificial Sequence

<223> "PCR Primer"

<220> 
<223> PCR Primer

<400> 5
tatttttttg tagttgggag tagtttat                                       28


<210> 6
<211> 27
<212> DNA
<213> Artificial Sequence

<223> "PCR Primer"

<220> 
<223> PCR Primer

<400> 6
ctttacaact aaaactaaaa aacctca                                        27


<210> 7
<211> 28
<212> DNA
<213> Artificial Sequence

<223> "PCR Primer"

<220> 
<223> PCR Primer

<400> 7
tgggagtagt ttatattaat agggttat                                       28


<210> 8
<211> 25
<212> DNA
<213> Artificial Sequence

<223> "PCR Primer"

<220> 
<223> PCR Primer

<400> 8
gaaacacctc tgtctttctc tttct                                          25


<210> 9
<211> 27
<212> DNA
<213> Artificial Sequence

<223> "PCR Primer"

<220> 
<223> PCR Primer

<400> 9
agttgggagt agtttatatt aataggg                                        27


<210> 10
<211> 25
<212> DNA
<213> Artificial Sequence

<223> "PCR Primer"

<220> 
<223> PCR Primer

<400> 10
ctctctctct gattctgctt ctcaa                                          25


<210> 11
<211> 35
<212> DNA
<213> Artificial Sequence

<223> "PCR Primer"

<220> 
<223> PCR Primer

<400> 11
tttttaaaat tatataatta taatgtataa aaaag                                35


<210> 12
<211> 27
<212> DNA
<213> Artificial Sequence

<223> "PCR Primer"

<220> 
<223> PCR Primer

<400> 12
ctggatctct cttatagagt ttccata                                        27


