                         SEQUENCE LISTING

<110>  Probiodrug AG
 
<120>  Humanized Antibodies

<130>  PBD128WO

<160>  74    

<170>  PatentIn version 3.5

<210>  1
<211>  42
<212>  PRT
<213>  Human

<400>  1

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210>  2
<211>  40
<212>  PRT
<213>  Human

<400>  2

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val 
        35                  40  


<210>  3
<211>  38
<212>  PRT
<213>  Human

<400>  3

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly 
        35              


<210>  4
<211>  40
<212>  PRT
<213>  Human

<400>  4

Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val 
1               5                   10                  15      


Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu 
            20                  25                  30          


Met Val Gly Gly Val Val Ile Ala 
        35                  40  


<210>  5
<211>  38
<212>  PRT
<213>  Human

<400>  5

Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val 
1               5                   10                  15      


Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu 
            20                  25                  30          


Met Val Gly Gly Val Val 
        35              


<210>  6
<211>  36
<212>  PRT
<213>  Human

<400>  6

Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val 
1               5                   10                  15      


Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu 
            20                  25                  30          


Met Val Gly Gly 
        35      


<210>  7
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  variable part of light chain


<220>
<221>  VARIANT
<222>  (31)..(31)
<223>  X is His or Tyr

<220>
<221>  VARIANT
<222>  (53)..(53)
<223>  Xaa is Ala, Ile or Thr

<400>  7

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Xaa Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Xaa Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Val Gln Gly 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  8
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  Variant
<222>  (8)..(8)
<223>  Xaa is His or Tyr

<400>  8

Lys Ser Ser Gln Ser Leu Leu Xaa Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  9
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  9

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  10
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  10

Val Gln Gly Thr His Phe Pro 
1               5           


<210>  11
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Val Gln Gly 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  12
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  12

Lys Ser Ser Gln Ser Leu Leu Tyr Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  13
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  13

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ala Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Val Gln Gly 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  14
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  14

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Thr Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Val Gln Gly 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  15
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  15

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Thr Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Val Gln Gly 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  16
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  16

Lys Ser Ser Gln Ser Leu Leu His Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  17
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  Variant
<222>  (32)..(32)
<223>  Xaa is His or Tyr

<220>
<221>  Variant
<222>  (54)..(54)
<223>  Xaa is Ser or Tyr

<220>
<221>  Variant
<222>  (56)..(56)
<223>  Xaa is Gly, Thr, Ala or Glu

<220>
<221>  Variant
<222>  (65)..(65)
<223>  Xaa is Lys or Gln

<220>
<221>  Variant
<222>  (70)..(70)
<223>  Xaa is Leu or Ile

<220>
<221>  Variant
<222>  (71)..(71)
<223>  Xaa is Ile or Thr

<220>
<221>  Variant
<222>  (80)..(80)
<223>  Xaa is Tyr or His

<220>
<221>  Variant
<222>  (93)..(93)
<223>  Xaa is Val or Thr

<400>  17

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Xaa 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Xaa Asn Xaa Val Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Xaa Gly Arg Val Thr Xaa Xaa Arg Asp Thr Ser Thr Thr Thr Val Xaa 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Xaa Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ala Lys Arg Glu Trp Asp Glu Thr Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  18
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  Variant
<222>  (7)..(7)
<223>  Xaa is Tyr or His

<400>  18

Gly Tyr Ser Phe Thr Gly Xaa Thr Met Asn 
1               5                   10  


<210>  19
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  Variant
<222>  (5)..(5)
<223>  Xaa is Tyr or Ser

<220>
<221>  Variant
<222>  (7)..(7)
<223>  Xaa is Gly, Thr, Ala or Glu

<220>
<221>  Variant
<222>  (16)..(16)
<223>  Xaa is Lys and Gln

<400>  19

Leu Ile Asn Pro Xaa Asn Xaa Val Thr Arg Tyr Asn Gln Lys Phe Xaa 
1               5                   10                  15      


Gly 
    


<210>  20
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  20

Glu Ala Lys Arg Glu Trp Asp Glu Thr Tyr 
1               5                   10  


<210>  21
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  21

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Val Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Ile Arg Asp Thr Ser Thr Thr Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ala Lys Arg Glu Trp Asp Glu Thr Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  22
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  22

Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn 
1               5                   10  


<210>  23
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  23

Leu Ile Asn Pro Tyr Asn Gly Val Thr Arg Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  24
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  24

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly His 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Ser Asn Gly Val Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Thr Thr Thr Val His 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ala Lys Arg Glu Trp Asp Glu Thr Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  25
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  25

Gly Tyr Ser Phe Thr Gly His Thr Met Asn 
1               5                   10  


<210>  26
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  26

Leu Ile Asn Pro Ser Asn Gly Val Thr Arg Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  27
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  27

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly His 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Ser Asn Gly Val Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Thr Thr Thr Val His 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ala Lys Arg Glu Trp Asp Glu Thr Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  28
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  29
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  29

Arg Ser Ser Gln Ser Leu Val His Ser Asp Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  30
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  30

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  31
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  31

Ser Gln Ser Thr His Val Pro Pro Thr 
1               5                   


<210>  32
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Phe Ile Ser Asn Leu Ala Tyr Ser Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Asp Asn Ile Leu Asp Tyr Val Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  33
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  33

Gly Phe Thr Phe Ser Asp Tyr Gly Met Ala 
1               5                   10  


<210>  34
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  34

Phe Ile Ser Asn Leu Ala Tyr Ser Ile Tyr Tyr Ala Asp Thr Val Thr 
1               5                   10                  15      


Gly 
    


<210>  35
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  35

Tyr Asp Tyr Asp Asn Ile Leu Asp Tyr Val Met Asp Tyr 
1               5                   10              


<210>  36
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  36

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Val Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Val Gln Gly 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  37
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  37

Lys Ser Ser Gln Ser Leu Leu Tyr Ser Asn Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  38
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  38

Val Val Ser Lys Leu Asp Ser 
1               5           


<210>  39
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  39

Val Gln Gly Thr His Phe Pro Phe Thr 
1               5                   


<210>  40
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  40

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Asn Asn Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Ile Val Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  41
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  41

Gly Tyr Ile Phe Asn Asn Tyr 
1               5           


<210>  42
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  42

Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  43
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  43

Glu Gly Tyr Ile Val Tyr 
1               5       


<210>  44
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCR primer

<400>  44
actgtggctg caccatctgt cttc                                              24


<210>  45
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCR primer

<400>  45
ctaacactct cccctgttga agctc                                             25


<210>  46
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCR primer

<400>  46
agggaaccct ggtcaccgtc tcc                                               23


<210>  47
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCR primer

<400>  47
tcatttaccc ggagacaggg agagg                                             25


<210>  48
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCR primer

<400>  48
caagtcagag cctcttatat agtg                                              24


<210>  49
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCR primer

<400>  49
gtaccttgca cgcagtaata aac                                               23


<210>  50
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<400>  50

Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val 
1               5                   10                  15      


<210>  51
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  51

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val 
        


<210>  52
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  52

Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu 
1               5                   10                  15      


Val 
    


<210>  53
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  53

Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val 
1               5                   10                  15  


<210>  54
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<400>  54

Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu 
1               5                   10                  15  


<210>  55
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<400>  55

Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  


<210>  56
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<400>  56

Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln 
1               5                   10              


<210>  57
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<400>  57

Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His 
1               5                   10          


<210>  58
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<400>  58

Glu Phe Arg His Asp Ser Gly Tyr Glu Val His 
1               5                   10      


<210>  59
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<400>  59

Glu Phe Arg His Asp Ser Gly Tyr Glu Val 
1               5                   10  


<210>  60
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<400>  60

Glu Phe Arg His Asp Ser Gly Tyr Glu 
1               5                   


<210>  61
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<400>  61

Glu Phe Arg His Asp Ser Gly Tyr 
1               5               


<210>  62
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<400>  62

Glu Phe Arg His Asp Ser Gly 
1               5           


<210>  63
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<400>  63

Glu Phe Arg His Asp Ser 
1               5       


<210>  64
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<400>  64

Glu Phe Arg His 
1               


<210>  65
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<400>  65

Glu Phe Arg 
1           


<210>  66
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  66

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly His 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Ser Asn Thr Val Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Thr Thr Thr Val His 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ala Lys Arg Glu Trp Asp Glu Thr Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  67
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  67

Leu Ile Asn Pro Ser Asn Thr Val Thr Arg Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  68
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  68

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly His 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Ser Asn Ala Val Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Thr Thr Thr Val His 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ala Lys Arg Glu Trp Asp Glu Thr Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  69
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  69

Leu Ile Asn Pro Ser Asn Ala Val Thr Arg Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  70
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  70

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly His 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Ser Asn Glu Val Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Thr Thr Thr Val His 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ala Lys Arg Glu Trp Asp Glu Thr Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  71
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  71

Leu Ile Asn Pro Ser Asn Glu Val Thr Arg Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  72
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<400>  72

Glu Phe Arg His Asp 
1               5   


<210>  73
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  73

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly His 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Ser Asn Glu Val Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Thr Thr Thr Val His 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ala Lys Arg Glu Trp Asp Glu Thr Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  74
<211>  449
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  74

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly His 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Ser Asn Glu Val Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Thr Thr Thr Val His 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ala Lys Arg Glu Trp Asp Glu Thr Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


