                               SEQUENCE LISTING

<110> MEMORIAL SLOAN-KETTERING CANCER CENTER
 
<120> COMBINATION THERAPY USING PDK1 AND PI3K INHIBITORS

<130> 072734.0413

<140> PCT/US2016/042616
<141> 2016-07-15

<150> 62/194,106
<151> 2015-07-17

<160> 72    

<170> PatentIn version 3.5

<210> 1
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(5)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ser or Thr 


<400> 1
Arg Xaa Arg Xaa Xaa Xaa 
1               5       


<210> 2
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Arg Ala Arg Ser Thr Ser 
1               5       


<210> 3
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Arg Cys Arg Ser Ile Ser 
1               5       


<210> 4
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Arg Asp Arg Val Arg Ser 
1               5       


<210> 5
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Arg Val Arg Ser Met Ser 
1               5       


<210> 6
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Arg Pro Arg Gly Tyr Thr 
1               5       


<210> 7
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Arg Lys Arg Leu Ile Ser 
1               5       


<210> 8
<211> 74
<212> PRT
<213> Homo sapiens

<400> 8
Asp Ser Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Glu Ala Phe Arg 
1               5                   10                  15      


Cys Arg Ser Ile Ser Val Ser Glu His Val Val Arg Ser Arg Ile Gln 
            20                  25                  30          


Thr Ser Leu Thr Arg Gly Ala Arg Asp Arg Val Arg Ser Met Ser Gly 
        35                  40                  45              


Gly His Ser Gly Leu Arg Pro Arg Gly Tyr Thr Ile Ser Asp Val Gly 
    50                  55                  60                  


Gln Arg Lys Arg Leu Ile Ser Ser Val Glu 
65                  70                  


<210> 9
<211> 74
<212> PRT
<213> Mus musculus

<400> 9
Asp Ser Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Glu Ala Phe Arg 
1               5                   10                  15      


Cys Arg Ser Ile Ser Val Ser Glu His Val Val Arg Ser Arg Ile Gln 
            20                  25                  30          


Thr Ser Leu Thr Arg Gly Ala Arg Asp Arg Val Arg Ser Met Ser Gly 
        35                  40                  45              


Gly His Ser Gly Leu Arg Pro Arg Gly Tyr Thr Ile Ser Asp Thr Gly 
    50                  55                  60                  


Gln Arg Lys Arg Leu Ile Ser Ser Val Asp 
65                  70                  


<210> 10
<211> 58
<212> PRT
<213> Rattus norvegicus

<400> 10
Asp Ser Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Ser Arg Ile Gln 
1               5                   10                  15      


Thr Ser Leu Thr Arg Gly Ala Arg Asp Arg Val Arg Ser Met Ser Gly 
            20                  25                  30          


Gly His Ser Gly Leu Arg Pro Arg Gly Tyr Thr Ile Ser Asp Thr Gly 
        35                  40                  45              


Gln Arg Lys Arg Leu Ile Ser Ser Val Asp 
    50                  55              


<210> 11
<211> 74
<212> PRT
<213> Bos taurus

<400> 11
Asp Ser Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Asp Ala Phe Arg 
1               5                   10                  15      


Cys Arg Ser Ile Ser Val Ser Glu His Val Val Arg Ser Arg Ile Gln 
            20                  25                  30          


Thr Ser Leu Thr His Gly Ala Arg Asp Arg Val Arg Ser Met Ser Gly 
        35                  40                  45              


Gly His Ser Gly Leu Arg Pro Arg Gly Tyr Thr Ile Ser Asp Thr Gly 
    50                  55                  60                  


Gln Arg Lys Arg Leu Val Ser Ser Val Asp 
65                  70                  


<210> 12
<211> 74
<212> PRT
<213> Gallus gallus domesticus

<400> 12
Asp Ser Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Asp Ala Phe Arg 
1               5                   10                  15      


Ser Arg Ser Ile Ser Val Ser Glu His Val Val Arg Ser Arg Ile Gln 
            20                  25                  30          


Thr Ser Ile Thr Arg Ser Ser Arg Asn Arg Val Arg Ser Met Ser Gly 
        35                  40                  45              


Gly His Ser Gly His Arg Pro Arg Gly Tyr Thr Ile Ser Asp Thr Gly 
    50                  55                  60                  


Gln Arg Lys Arg Leu Ile Ser Ser Val Asp 
65                  70                  


<210> 13
<211> 58
<212> PRT
<213> Xenopus tropicalis

<400> 13
Asp Ser Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Ser Arg Met Gln 
1               5                   10                  15      


Thr Ser Val Thr Gln Thr Pro Arg His Arg Val Arg Ser Met Ser Gly 
            20                  25                  30          


Gly Thr Thr Gly His Arg Pro Arg Gly His Thr Ile Ser Asp Thr Gly 
        35                  40                  45              


Gln Arg Thr Arg Leu Ile Ser Ala Val Asp 
    50                  55              


<210> 14
<211> 73
<212> PRT
<213> Danio rerio

<400> 14
Asp Ser Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Asp Ala Phe Arg 
1               5                   10                  15      


Ser Arg Ser Ile Ser Val Ser Glu His Ala Val Arg Arg Met Gln Thr 
            20                  25                  30          


Ser Ser Thr Thr Asn Thr Arg Thr Arg Val Arg Ser Ile Ser Gly Gly 
        35                  40                  45              


His Thr Gly His Arg Pro Arg Gly His Thr Ile Ser Val Ala Gly Gln 
    50                  55                  60                  


Arg Lys Arg Leu Val Ser Thr Val Asp 
65                  70              


<210> 15
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(5)
<223> Any amino acid

<400> 15
Arg Xaa Arg Xaa Xaa Ser 
1               5       


<210> 16
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(5)
<223> Any amino acid

<400> 16
Arg Xaa Arg Xaa Xaa Ser 
1               5       


<210> 17
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(5)
<223> Any amino acid

<400> 17
Arg Xaa Arg Xaa Xaa Thr 
1               5       


<210> 18
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(5)
<223> Any amino acid

<400> 18
Arg Xaa Arg Xaa Xaa Ser 
1               5       


<210> 19
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(5)
<223> Any amino acid

<400> 19
Arg Xaa Arg Xaa Xaa Ser 
1               5       


<210> 20
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(5)
<223> Any amino acid

<400> 20
Arg Xaa Arg Xaa Xaa Thr 
1               5       


<210> 21
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(5)
<223> Any amino acid

<400> 21
Arg Xaa Arg Xaa Xaa Ser 
1               5       


<210> 22
<211> 454
<212> PRT
<213> Homo sapiens

<400> 22
Met Ala Arg Thr Thr Ser Gln Leu Tyr Asp Ala Val Pro Ile Gln Ser 
1               5                   10                  15      


Ser Val Val Leu Cys Ser Cys Pro Ser Pro Ser Met Val Arg Thr Gln 
            20                  25                  30          


Thr Glu Ser Ser Thr Pro Pro Gly Ile Pro Gly Gly Ser Arg Gln Gly 
        35                  40                  45              


Pro Ala Met Asp Gly Thr Ala Ala Glu Pro Arg Pro Gly Ala Gly Ser 
    50                  55                  60                  


Leu Gln His Ala Gln Pro Pro Pro Gln Pro Arg Lys Lys Arg Pro Glu 
65                  70                  75                  80  


Asp Phe Lys Phe Gly Lys Ile Leu Gly Glu Gly Ser Phe Ser Thr Val 
                85                  90                  95      


Val Leu Ala Arg Glu Leu Ala Thr Ser Arg Glu Tyr Ala Ile Lys Ile 
            100                 105                 110         


Leu Glu Lys Arg His Ile Ile Lys Glu Asn Lys Val Pro Tyr Val Thr 
        115                 120                 125             


Arg Glu Arg Asp Val Met Ser Arg Leu Asp His Pro Phe Phe Val Lys 
    130                 135                 140                 


Leu Tyr Phe Thr Phe Gln Asp Asp Glu Lys Leu Tyr Phe Gly Leu Ser 
145                 150                 155                 160 


Tyr Ala Lys Asn Gly Glu Leu Leu Lys Tyr Ile Arg Lys Ile Gly Ser 
                165                 170                 175     


Phe Asp Glu Thr Cys Thr Arg Phe Tyr Thr Ala Glu Ile Val Ser Ala 
            180                 185                 190         


Leu Glu Tyr Leu His Gly Lys Gly Ile Ile His Arg Asp Leu Lys Pro 
        195                 200                 205             


Glu Asn Ile Leu Leu Asn Glu Asp Met His Ile Gln Ile Thr Asp Phe 
    210                 215                 220                 


Gly Thr Ala Lys Val Leu Ser Pro Glu Ser Lys Gln Ala Arg Ala Asn 
225                 230                 235                 240 


Ser Phe Val Gly Thr Ala Gln Tyr Val Ser Pro Glu Leu Leu Thr Glu 
                245                 250                 255     


Lys Ser Ala Cys Lys Ser Ser Asp Leu Trp Ala Leu Gly Cys Ile Ile 
            260                 265                 270         


Tyr Gln Leu Val Ala Gly Leu Pro Pro Phe Arg Ala Gly Asn Glu Tyr 
        275                 280                 285             


Leu Ile Phe Gln Lys Ile Ile Lys Leu Glu Tyr Asp Phe Pro Glu Lys 
    290                 295                 300                 


Phe Phe Pro Lys Ala Arg Asp Leu Val Glu Lys Leu Leu Val Leu Asp 
305                 310                 315                 320 


Ala Thr Lys Arg Leu Gly Cys Glu Glu Met Glu Gly Tyr Gly Pro Leu 
                325                 330                 335     


Lys Ala His Pro Phe Phe Glu Ser Val Thr Trp Glu Asn Leu His Gln 
            340                 345                 350         


Gln Thr Pro Pro Lys Leu Thr Ala Tyr Leu Pro Ala Met Ser Glu Asp 
        355                 360                 365             


Asp Glu Asp Cys Tyr Gly Asn Tyr Asp Asn Leu Leu Ser Gln Phe Gly 
    370                 375                 380                 


Cys Met Gln Val Ser Ser Ser Ser Ser Ser His Ser Leu Ser Ala Ser 
385                 390                 395                 400 


Asp Thr Gly Leu Pro Gln Arg Ser Gly Ser Asn Ile Glu Gln Tyr Ile 
                405                 410                 415     


His Asp Leu Asp Ser Asn Ser Phe Glu Leu Asp Leu Gln Phe Ser Glu 
            420                 425                 430         


Asp Glu Lys Arg Leu Leu Leu Glu Lys Gln Ala Gly Gly Asn Pro Cys 
        435                 440                 445             


Leu Thr Gly Arg Ile Ile 
    450                 


<210> 23
<211> 556
<212> PRT
<213> Homo sapiens

<400> 23
Met Ala Arg Thr Thr Ser Gln Leu Tyr Asp Ala Val Pro Ile Gln Ser 
1               5                   10                  15      


Ser Val Val Leu Cys Ser Cys Pro Ser Pro Ser Met Val Arg Thr Gln 
            20                  25                  30          


Thr Glu Ser Ser Thr Pro Pro Gly Ile Pro Gly Gly Ser Arg Gln Gly 
        35                  40                  45              


Pro Ala Met Asp Gly Thr Ala Ala Glu Pro Arg Pro Gly Ala Gly Ser 
    50                  55                  60                  


Leu Gln His Ala Gln Pro Pro Pro Gln Pro Arg Lys Lys Arg Pro Glu 
65                  70                  75                  80  


Asp Phe Lys Phe Gly Lys Ile Leu Gly Glu Gly Ser Phe Ser Thr Val 
                85                  90                  95      


Val Leu Ala Arg Glu Leu Ala Thr Ser Arg Glu Tyr Ala Ile Lys Ile 
            100                 105                 110         


Leu Glu Lys Arg His Ile Ile Lys Glu Asn Lys Val Pro Tyr Val Thr 
        115                 120                 125             


Arg Glu Arg Asp Val Met Ser Arg Leu Asp His Pro Phe Phe Val Lys 
    130                 135                 140                 


Leu Tyr Phe Thr Phe Gln Asp Asp Glu Lys Leu Tyr Phe Gly Leu Ser 
145                 150                 155                 160 


Tyr Ala Lys Asn Gly Glu Leu Leu Lys Tyr Ile Arg Lys Ile Gly Ser 
                165                 170                 175     


Phe Asp Glu Thr Cys Thr Arg Phe Tyr Thr Ala Glu Ile Val Ser Ala 
            180                 185                 190         


Leu Glu Tyr Leu His Gly Lys Gly Ile Ile His Arg Asp Leu Lys Pro 
        195                 200                 205             


Glu Asn Ile Leu Leu Asn Glu Asp Met His Ile Gln Ile Thr Asp Phe 
    210                 215                 220                 


Gly Thr Ala Lys Val Leu Ser Pro Glu Ser Lys Gln Ala Arg Ala Asn 
225                 230                 235                 240 


Ser Phe Val Gly Thr Ala Gln Tyr Val Ser Pro Glu Leu Leu Thr Glu 
                245                 250                 255     


Lys Ser Ala Cys Lys Ser Ser Asp Leu Trp Ala Leu Gly Cys Ile Ile 
            260                 265                 270         


Tyr Gln Leu Val Ala Gly Leu Pro Pro Phe Arg Ala Gly Asn Glu Tyr 
        275                 280                 285             


Leu Ile Phe Gln Lys Ile Ile Lys Leu Glu Tyr Asp Phe Pro Glu Lys 
    290                 295                 300                 


Phe Phe Pro Lys Ala Arg Asp Leu Val Glu Lys Leu Leu Val Leu Asp 
305                 310                 315                 320 


Ala Thr Lys Arg Leu Gly Cys Glu Glu Met Glu Gly Tyr Gly Pro Leu 
                325                 330                 335     


Lys Ala His Pro Phe Phe Glu Ser Val Thr Trp Glu Asn Leu His Gln 
            340                 345                 350         


Gln Thr Pro Pro Lys Leu Thr Ala Tyr Leu Pro Ala Met Ser Glu Asp 
        355                 360                 365             


Asp Glu Asp Cys Tyr Gly Asn Tyr Asp Asn Leu Leu Ser Gln Phe Gly 
    370                 375                 380                 


Cys Met Gln Val Ser Ser Ser Ser Ser Ser His Ser Leu Ser Ala Ser 
385                 390                 395                 400 


Asp Thr Gly Leu Pro Gln Arg Ser Gly Ser Asn Ile Glu Gln Tyr Ile 
                405                 410                 415     


His Asp Leu Asp Ser Asn Ser Phe Glu Leu Asp Leu Gln Phe Ser Glu 
            420                 425                 430         


Asp Glu Lys Arg Leu Leu Leu Glu Lys Gln Ala Gly Gly Asn Pro Trp 
        435                 440                 445             


His Gln Phe Val Glu Asn Asn Leu Ile Leu Lys Met Gly Pro Val Asp 
    450                 455                 460                 


Lys Arg Lys Gly Leu Phe Ala Arg Arg Arg Gln Leu Leu Leu Thr Glu 
465                 470                 475                 480 


Gly Pro His Leu Tyr Tyr Val Asp Pro Val Asn Lys Val Leu Lys Gly 
                485                 490                 495     


Glu Ile Pro Trp Ser Gln Glu Leu Arg Pro Glu Ala Lys Asn Phe Lys 
            500                 505                 510         


Thr Phe Phe Val His Thr Pro Asn Arg Thr Tyr Tyr Leu Met Asp Pro 
        515                 520                 525             


Ser Gly Asn Ala His Lys Trp Cys Arg Lys Ile Gln Glu Val Trp Arg 
    530                 535                 540                 


Gln Arg Tyr Gln Ser His Pro Asp Ala Ala Val Gln 
545                 550                 555     


<210> 24
<211> 429
<212> PRT
<213> Homo sapiens

<400> 24
Met Ala Arg Thr Thr Ser Gln Leu Tyr Asp Ala Val Pro Ile Gln Ser 
1               5                   10                  15      


Ser Val Val Leu Cys Ser Cys Pro Ser Pro Ser Met Val Arg Thr Gln 
            20                  25                  30          


Thr Glu Ser Ser Thr Pro Pro Gly Ile Pro Gly Gly Ser Arg Gln Gly 
        35                  40                  45              


Pro Ala Met Asp Gly Thr Ala Ala Glu Pro Arg Pro Gly Ala Gly Ser 
    50                  55                  60                  


Leu Gln His Ala Gln Pro Pro Pro Gln Pro Arg Lys Lys Arg Pro Glu 
65                  70                  75                  80  


Asp Phe Lys Phe Gly Lys Ile Leu Gly Glu Gly Ser Phe Ser Thr Val 
                85                  90                  95      


Val Leu Ala Arg Glu Leu Ala Thr Ser Arg Glu Tyr Ala Thr Arg Ala 
            100                 105                 110         


Asn Ser Phe Val Gly Thr Ala Gln Tyr Val Ser Pro Glu Leu Leu Thr 
        115                 120                 125             


Glu Lys Ser Ala Cys Lys Ser Ser Asp Leu Trp Ala Leu Gly Cys Ile 
    130                 135                 140                 


Ile Tyr Gln Leu Val Ala Gly Leu Pro Pro Phe Arg Ala Gly Asn Glu 
145                 150                 155                 160 


Tyr Leu Ile Phe Gln Lys Ile Ile Lys Leu Glu Tyr Asp Phe Pro Glu 
                165                 170                 175     


Lys Phe Phe Pro Lys Ala Arg Asp Leu Val Glu Lys Leu Leu Val Leu 
            180                 185                 190         


Asp Ala Thr Lys Arg Leu Gly Cys Glu Glu Met Glu Gly Tyr Gly Pro 
        195                 200                 205             


Leu Lys Ala His Pro Phe Phe Glu Ser Val Thr Trp Glu Asn Leu His 
    210                 215                 220                 


Gln Gln Thr Pro Pro Lys Leu Thr Ala Tyr Leu Pro Ala Met Ser Glu 
225                 230                 235                 240 


Asp Asp Glu Asp Cys Tyr Gly Asn Tyr Asp Asn Leu Leu Ser Gln Phe 
                245                 250                 255     


Gly Cys Met Gln Val Ser Ser Ser Ser Ser Ser His Ser Leu Ser Ala 
            260                 265                 270         


Ser Asp Thr Gly Leu Pro Gln Arg Ser Gly Ser Asn Ile Glu Gln Tyr 
        275                 280                 285             


Ile His Asp Leu Asp Ser Asn Ser Phe Glu Leu Asp Leu Gln Phe Ser 
    290                 295                 300                 


Glu Asp Glu Lys Arg Leu Leu Leu Glu Lys Gln Ala Gly Gly Asn Pro 
305                 310                 315                 320 


Trp His Gln Phe Val Glu Asn Asn Leu Ile Leu Lys Met Gly Pro Val 
                325                 330                 335     


Asp Lys Arg Lys Gly Leu Phe Ala Arg Arg Arg Gln Leu Leu Leu Thr 
            340                 345                 350         


Glu Gly Pro His Leu Tyr Tyr Val Asp Pro Val Asn Lys Val Leu Lys 
        355                 360                 365             


Gly Glu Ile Pro Trp Ser Gln Glu Leu Arg Pro Glu Ala Lys Asn Phe 
    370                 375                 380                 


Lys Thr Phe Phe Val His Thr Pro Asn Arg Thr Tyr Tyr Leu Met Asp 
385                 390                 395                 400 


Pro Ser Gly Asn Ala His Lys Trp Cys Arg Lys Ile Gln Glu Val Trp 
                405                 410                 415     


Arg Gln Arg Tyr Gln Ser His Pro Asp Ala Ala Val Gln 
            420                 425                 


<210> 25
<211> 526
<212> PRT
<213> Homo sapiens

<400> 25
Met Val Asn Lys Asp Met Asn Gly Phe Pro Val Lys Lys Cys Ser Ala 
1               5                   10                  15      


Phe Gln Phe Phe Lys Lys Arg Val Arg Arg Trp Ile Lys Ser Pro Met 
            20                  25                  30          


Val Ser Val Asp Lys His Gln Ser Pro Ser Leu Lys Tyr Thr Gly Ser 
        35                  40                  45              


Ser Met Val His Ile Pro Pro Gly Glu Pro Asp Phe Glu Ser Ser Leu 
    50                  55                  60                  


Cys Gln Thr Cys Leu Gly Glu His Ala Phe Gln Arg Gly Val Leu Pro 
65                  70                  75                  80  


Gln Glu Asn Glu Ser Cys Ser Trp Glu Thr Gln Ser Gly Cys Glu Val 
                85                  90                  95      


Arg Glu Pro Cys Asn His Ala Asn Ile Leu Thr Lys Pro Asp Pro Arg 
            100                 105                 110         


Thr Phe Trp Thr Asn Asp Asp Pro Ala Phe Met Lys Gln Arg Arg Met 
        115                 120                 125             


Gly Leu Asn Asp Phe Ile Gln Lys Ile Ala Asn Asn Ser Tyr Ala Cys 
    130                 135                 140                 


Lys His Pro Glu Val Gln Ser Ile Leu Lys Ile Ser Gln Pro Gln Glu 
145                 150                 155                 160 


Pro Glu Leu Met Asn Ala Asn Pro Ser Pro Pro Pro Ser Pro Ser Gln 
                165                 170                 175     


Gln Ile Asn Leu Gly Pro Ser Ser Asn Pro His Ala Lys Pro Ser Asp 
            180                 185                 190         


Phe His Phe Leu Lys Val Ile Gly Lys Gly Ser Phe Gly Lys Val Leu 
        195                 200                 205             


Leu Ala Arg His Lys Ala Glu Glu Val Phe Tyr Ala Val Lys Val Leu 
    210                 215                 220                 


Gln Lys Lys Ala Ile Leu Lys Lys Lys Glu Glu Lys His Ile Met Ser 
225                 230                 235                 240 


Glu Arg Asn Val Leu Leu Lys Asn Val Lys His Pro Phe Leu Val Gly 
                245                 250                 255     


Leu His Phe Ser Phe Gln Thr Ala Asp Lys Leu Tyr Phe Val Leu Asp 
            260                 265                 270         


Tyr Ile Asn Gly Gly Glu Leu Phe Tyr His Leu Gln Arg Glu Arg Cys 
        275                 280                 285             


Phe Leu Glu Pro Arg Ala Arg Phe Tyr Ala Ala Glu Ile Ala Ser Ala 
    290                 295                 300                 


Leu Gly Tyr Leu His Ser Leu Asn Ile Val Tyr Arg Asp Leu Lys Pro 
305                 310                 315                 320 


Glu Asn Ile Leu Leu Asp Ser Gln Gly His Ile Val Leu Thr Asp Phe 
                325                 330                 335     


Gly Leu Cys Lys Glu Asn Ile Glu His Asn Ser Thr Thr Ser Thr Phe 
            340                 345                 350         


Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val Leu His Lys Gln Pro 
        355                 360                 365             


Tyr Asp Arg Thr Val Asp Trp Trp Cys Leu Gly Ala Val Leu Tyr Glu 
    370                 375                 380                 


Met Leu Tyr Gly Leu Pro Pro Phe Tyr Ser Arg Asn Thr Ala Glu Met 
385                 390                 395                 400 


Tyr Asp Asn Ile Leu Asn Lys Pro Leu Gln Leu Lys Pro Asn Ile Thr 
                405                 410                 415     


Asn Ser Ala Arg His Leu Leu Glu Gly Leu Leu Gln Lys Asp Arg Thr 
            420                 425                 430         


Lys Arg Leu Gly Ala Lys Asp Asp Phe Met Glu Ile Lys Ser His Val 
        435                 440                 445             


Phe Phe Ser Leu Ile Asn Trp Asp Asp Leu Ile Asn Lys Lys Ile Thr 
    450                 455                 460                 


Pro Pro Phe Asn Pro Asn Val Ser Gly Pro Asn Asp Leu Arg His Phe 
465                 470                 475                 480 


Asp Pro Glu Phe Thr Glu Glu Pro Val Pro Asn Ser Ile Gly Lys Ser 
                485                 490                 495     


Pro Asp Ser Val Leu Val Thr Ala Ser Val Lys Glu Ala Ala Glu Ala 
            500                 505                 510         


Phe Leu Gly Phe Ser Tyr Ala Pro Pro Thr Asp Ser Phe Leu 
        515                 520                 525     


<210> 26
<211> 459
<212> PRT
<213> Homo sapiens

<400> 26
Met Ser Ser Gln Ser Ser Ser Leu Ser Glu Ala Cys Ser Arg Glu Ala 
1               5                   10                  15      


Tyr Ser Ser His Asn Trp Ala Leu Pro Pro Ala Ser Arg Ser Asn Pro 
            20                  25                  30          


Gln Pro Ala Tyr Pro Trp Ala Thr Arg Arg Met Lys Glu Glu Ala Ile 
        35                  40                  45              


Lys Pro Pro Leu Lys Ala Phe Met Lys Gln Arg Arg Met Gly Leu Asn 
    50                  55                  60                  


Asp Phe Ile Gln Lys Ile Ala Asn Asn Ser Tyr Ala Cys Lys His Pro 
65                  70                  75                  80  


Glu Val Gln Ser Ile Leu Lys Ile Ser Gln Pro Gln Glu Pro Glu Leu 
                85                  90                  95      


Met Asn Ala Asn Pro Ser Pro Pro Pro Ser Pro Ser Gln Gln Ile Asn 
            100                 105                 110         


Leu Gly Pro Ser Ser Asn Pro His Ala Lys Pro Ser Asp Phe His Phe 
        115                 120                 125             


Leu Lys Val Ile Gly Lys Gly Ser Phe Gly Lys Val Leu Leu Ala Arg 
    130                 135                 140                 


His Lys Ala Glu Glu Val Phe Tyr Ala Val Lys Val Leu Gln Lys Lys 
145                 150                 155                 160 


Ala Ile Leu Lys Lys Lys Glu Glu Lys His Ile Met Ser Glu Arg Asn 
                165                 170                 175     


Val Leu Leu Lys Asn Val Lys His Pro Phe Leu Val Gly Leu His Phe 
            180                 185                 190         


Ser Phe Gln Thr Ala Asp Lys Leu Tyr Phe Val Leu Asp Tyr Ile Asn 
        195                 200                 205             


Gly Gly Glu Leu Phe Tyr His Leu Gln Arg Glu Arg Cys Phe Leu Glu 
    210                 215                 220                 


Pro Arg Ala Arg Phe Tyr Ala Ala Glu Ile Ala Ser Ala Leu Gly Tyr 
225                 230                 235                 240 


Leu His Ser Leu Asn Ile Val Tyr Arg Asp Leu Lys Pro Glu Asn Ile 
                245                 250                 255     


Leu Leu Asp Ser Gln Gly His Ile Val Leu Thr Asp Phe Gly Leu Cys 
            260                 265                 270         


Lys Glu Asn Ile Glu His Asn Ser Thr Thr Ser Thr Phe Cys Gly Thr 
        275                 280                 285             


Pro Glu Tyr Leu Ala Pro Glu Val Leu His Lys Gln Pro Tyr Asp Arg 
    290                 295                 300                 


Thr Val Asp Trp Trp Cys Leu Gly Ala Val Leu Tyr Glu Met Leu Tyr 
305                 310                 315                 320 


Gly Leu Pro Pro Phe Tyr Ser Arg Asn Thr Ala Glu Met Tyr Asp Asn 
                325                 330                 335     


Ile Leu Asn Lys Pro Leu Gln Leu Lys Pro Asn Ile Thr Asn Ser Ala 
            340                 345                 350         


Arg His Leu Leu Glu Gly Leu Leu Gln Lys Asp Arg Thr Lys Arg Leu 
        355                 360                 365             


Gly Ala Lys Asp Asp Phe Met Glu Ile Lys Ser His Val Phe Phe Ser 
    370                 375                 380                 


Leu Ile Asn Trp Asp Asp Leu Ile Asn Lys Lys Ile Thr Pro Pro Phe 
385                 390                 395                 400 


Asn Pro Asn Val Ser Gly Pro Asn Asp Leu Arg His Phe Asp Pro Glu 
                405                 410                 415     


Phe Thr Glu Glu Pro Val Pro Asn Ser Ile Gly Lys Ser Pro Asp Ser 
            420                 425                 430         


Val Leu Val Thr Ala Ser Val Lys Glu Ala Ala Glu Ala Phe Leu Gly 
        435                 440                 445             


Phe Ser Tyr Ala Pro Pro Thr Asp Ser Phe Leu 
    450                 455                 


<210> 27
<211> 445
<212> PRT
<213> Homo sapiens

<400> 27
Met Gly Glu Met Gln Gly Ala Leu Ala Arg Ala Arg Leu Glu Ser Leu 
1               5                   10                  15      


Leu Arg Pro Arg His Lys Lys Arg Ala Glu Ala Gln Lys Arg Ser Glu 
            20                  25                  30          


Ser Phe Leu Leu Ser Gly Leu Ala Phe Met Lys Gln Arg Arg Met Gly 
        35                  40                  45              


Leu Asn Asp Phe Ile Gln Lys Ile Ala Asn Asn Ser Tyr Ala Cys Lys 
    50                  55                  60                  


His Pro Glu Val Gln Ser Ile Leu Lys Ile Ser Gln Pro Gln Glu Pro 
65                  70                  75                  80  


Glu Leu Met Asn Ala Asn Pro Ser Pro Pro Pro Ser Pro Ser Gln Gln 
                85                  90                  95      


Ile Asn Leu Gly Pro Ser Ser Asn Pro His Ala Lys Pro Ser Asp Phe 
            100                 105                 110         


His Phe Leu Lys Val Ile Gly Lys Gly Ser Phe Gly Lys Val Leu Leu 
        115                 120                 125             


Ala Arg His Lys Ala Glu Glu Val Phe Tyr Ala Val Lys Val Leu Gln 
    130                 135                 140                 


Lys Lys Ala Ile Leu Lys Lys Lys Glu Glu Lys His Ile Met Ser Glu 
145                 150                 155                 160 


Arg Asn Val Leu Leu Lys Asn Val Lys His Pro Phe Leu Val Gly Leu 
                165                 170                 175     


His Phe Ser Phe Gln Thr Ala Asp Lys Leu Tyr Phe Val Leu Asp Tyr 
            180                 185                 190         


Ile Asn Gly Gly Glu Leu Phe Tyr His Leu Gln Arg Glu Arg Cys Phe 
        195                 200                 205             


Leu Glu Pro Arg Ala Arg Phe Tyr Ala Ala Glu Ile Ala Ser Ala Leu 
    210                 215                 220                 


Gly Tyr Leu His Ser Leu Asn Ile Val Tyr Arg Asp Leu Lys Pro Glu 
225                 230                 235                 240 


Asn Ile Leu Leu Asp Ser Gln Gly His Ile Val Leu Thr Asp Phe Gly 
                245                 250                 255     


Leu Cys Lys Glu Asn Ile Glu His Asn Ser Thr Thr Ser Thr Phe Cys 
            260                 265                 270         


Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val Leu His Lys Gln Pro Tyr 
        275                 280                 285             


Asp Arg Thr Val Asp Trp Trp Cys Leu Gly Ala Val Leu Tyr Glu Met 
    290                 295                 300                 


Leu Tyr Gly Leu Pro Pro Phe Tyr Ser Arg Asn Thr Ala Glu Met Tyr 
305                 310                 315                 320 


Asp Asn Ile Leu Asn Lys Pro Leu Gln Leu Lys Pro Asn Ile Thr Asn 
                325                 330                 335     


Ser Ala Arg His Leu Leu Glu Gly Leu Leu Gln Lys Asp Arg Thr Lys 
            340                 345                 350         


Arg Leu Gly Ala Lys Asp Asp Phe Met Glu Ile Lys Ser His Val Phe 
        355                 360                 365             


Phe Ser Leu Ile Asn Trp Asp Asp Leu Ile Asn Lys Lys Ile Thr Pro 
    370                 375                 380                 


Pro Phe Asn Pro Asn Val Ser Gly Pro Asn Asp Leu Arg His Phe Asp 
385                 390                 395                 400 


Pro Glu Phe Thr Glu Glu Pro Val Pro Asn Ser Ile Gly Lys Ser Pro 
                405                 410                 415     


Asp Ser Val Leu Val Thr Ala Ser Val Lys Glu Ala Ala Glu Ala Phe 
            420                 425                 430         


Leu Gly Phe Ser Tyr Ala Pro Pro Thr Asp Ser Phe Leu 
        435                 440                 445 


<210> 28
<211> 387
<212> PRT
<213> Homo sapiens

<400> 28
Met Thr Val Lys Thr Glu Ala Ala Lys Gly Thr Leu Thr Tyr Ser Arg 
1               5                   10                  15      


Met Arg Gly Met Val Ala Ile Leu Ile Ala Phe Met Lys Gln Arg Arg 
            20                  25                  30          


Met Gly Leu Asn Asp Phe Ile Gln Lys Ile Ala Asn Asn Ser Tyr Ala 
        35                  40                  45              


Cys Lys His Pro Glu Val Gln Ser Ile Leu Lys Ile Ser Gln Pro Gln 
    50                  55                  60                  


Glu Pro Glu Leu Met Asn Ala Asn Pro Ser Pro Pro Pro Ser Pro Ser 
65                  70                  75                  80  


Gln Gln Ile Asn Leu Gly Pro Ser Ser Asn Pro His Ala Lys Pro Ser 
                85                  90                  95      


Asp Phe His Phe Leu Lys Val Ile Gly Lys Gly Ser Phe Gly Lys Val 
            100                 105                 110         


Leu Leu Ala Arg His Lys Ala Glu Glu Val Phe Tyr Ala Val Lys Val 
        115                 120                 125             


Leu Gln Lys Lys Ala Ile Leu Lys Lys Lys Glu Leu Phe Tyr His Leu 
    130                 135                 140                 


Gln Arg Glu Arg Cys Phe Leu Glu Pro Arg Ala Arg Phe Tyr Ala Ala 
145                 150                 155                 160 


Glu Ile Ala Ser Ala Leu Gly Tyr Leu His Ser Leu Asn Ile Val Tyr 
                165                 170                 175     


Arg Asp Leu Lys Pro Glu Asn Ile Leu Leu Asp Ser Gln Gly His Ile 
            180                 185                 190         


Val Leu Thr Asp Phe Gly Leu Cys Lys Glu Asn Ile Glu His Asn Ser 
        195                 200                 205             


Thr Thr Ser Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val 
    210                 215                 220                 


Leu His Lys Gln Pro Tyr Asp Arg Thr Val Asp Trp Trp Cys Leu Gly 
225                 230                 235                 240 


Ala Val Leu Tyr Glu Met Leu Tyr Gly Leu Pro Pro Phe Tyr Ser Arg 
                245                 250                 255     


Asn Thr Ala Glu Met Tyr Asp Asn Ile Leu Asn Lys Pro Leu Gln Leu 
            260                 265                 270         


Lys Pro Asn Ile Thr Asn Ser Ala Arg His Leu Leu Glu Gly Leu Leu 
        275                 280                 285             


Gln Lys Asp Arg Thr Lys Arg Leu Gly Ala Lys Asp Asp Phe Met Glu 
    290                 295                 300                 


Ile Lys Ser His Val Phe Phe Ser Leu Ile Asn Trp Asp Asp Leu Ile 
305                 310                 315                 320 


Asn Lys Lys Ile Thr Pro Pro Phe Asn Pro Asn Val Ser Gly Pro Asn 
                325                 330                 335     


Asp Leu Arg His Phe Asp Pro Glu Phe Thr Glu Glu Pro Val Pro Asn 
            340                 345                 350         


Ser Ile Gly Lys Ser Pro Asp Ser Val Leu Val Thr Ala Ser Val Lys 
        355                 360                 365             


Glu Ala Ala Glu Ala Phe Leu Gly Phe Ser Tyr Ala Pro Pro Thr Asp 
    370                 375                 380                 


Ser Phe Leu 
385         


<210> 29
<211> 431
<212> PRT
<213> Homo sapiens

<400> 29
Met Thr Val Lys Thr Glu Ala Ala Lys Gly Thr Leu Thr Tyr Ser Arg 
1               5                   10                  15      


Met Arg Gly Met Val Ala Ile Leu Ile Ala Phe Met Lys Gln Arg Arg 
            20                  25                  30          


Met Gly Leu Asn Asp Phe Ile Gln Lys Ile Ala Asn Asn Ser Tyr Ala 
        35                  40                  45              


Cys Lys His Pro Glu Val Gln Ser Ile Leu Lys Ile Ser Gln Pro Gln 
    50                  55                  60                  


Glu Pro Glu Leu Met Asn Ala Asn Pro Ser Pro Pro Pro Ser Pro Ser 
65                  70                  75                  80  


Gln Gln Ile Asn Leu Gly Pro Ser Ser Asn Pro His Ala Lys Pro Ser 
                85                  90                  95      


Asp Phe His Phe Leu Lys Val Ile Gly Lys Gly Ser Phe Gly Lys Val 
            100                 105                 110         


Leu Leu Ala Arg His Lys Ala Glu Glu Val Phe Tyr Ala Val Lys Val 
        115                 120                 125             


Leu Gln Lys Lys Ala Ile Leu Lys Lys Lys Glu Glu Lys His Ile Met 
    130                 135                 140                 


Ser Glu Arg Asn Val Leu Leu Lys Asn Val Lys His Pro Phe Leu Val 
145                 150                 155                 160 


Gly Leu His Phe Ser Phe Gln Thr Ala Asp Lys Leu Tyr Phe Val Leu 
                165                 170                 175     


Asp Tyr Ile Asn Gly Gly Glu Leu Phe Tyr His Leu Gln Arg Glu Arg 
            180                 185                 190         


Cys Phe Leu Glu Pro Arg Ala Arg Phe Tyr Ala Ala Glu Ile Ala Ser 
        195                 200                 205             


Ala Leu Gly Tyr Leu His Ser Leu Asn Ile Val Tyr Arg Asp Leu Lys 
    210                 215                 220                 


Pro Glu Asn Ile Leu Leu Asp Ser Gln Gly His Ile Val Leu Thr Asp 
225                 230                 235                 240 


Phe Gly Leu Cys Lys Glu Asn Ile Glu His Asn Ser Thr Thr Ser Thr 
                245                 250                 255     


Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val Leu His Lys Gln 
            260                 265                 270         


Pro Tyr Asp Arg Thr Val Asp Trp Trp Cys Leu Gly Ala Val Leu Tyr 
        275                 280                 285             


Glu Met Leu Tyr Gly Leu Pro Pro Phe Tyr Ser Arg Asn Thr Ala Glu 
    290                 295                 300                 


Met Tyr Asp Asn Ile Leu Asn Lys Pro Leu Gln Leu Lys Pro Asn Ile 
305                 310                 315                 320 


Thr Asn Ser Ala Arg His Leu Leu Glu Gly Leu Leu Gln Lys Asp Arg 
                325                 330                 335     


Thr Lys Arg Leu Gly Ala Lys Asp Asp Phe Met Glu Ile Lys Ser His 
            340                 345                 350         


Val Phe Phe Ser Leu Ile Asn Trp Asp Asp Leu Ile Asn Lys Lys Ile 
        355                 360                 365             


Thr Pro Pro Phe Asn Pro Asn Val Ser Gly Pro Asn Asp Leu Arg His 
    370                 375                 380                 


Phe Asp Pro Glu Phe Thr Glu Glu Pro Val Pro Asn Ser Ile Gly Lys 
385                 390                 395                 400 


Ser Pro Asp Ser Val Leu Val Thr Ala Ser Val Lys Glu Ala Ala Glu 
                405                 410                 415     


Ala Phe Leu Gly Phe Ser Tyr Ala Pro Pro Thr Asp Ser Phe Leu 
            420                 425                 430     


<210> 30
<211> 1068
<212> PRT
<213> Homo sapiens

<400> 30
Met Pro Pro Arg Pro Ser Ser Gly Glu Leu Trp Gly Ile His Leu Met 
1               5                   10                  15      


Pro Pro Arg Ile Leu Val Glu Cys Leu Leu Pro Asn Gly Met Ile Val 
            20                  25                  30          


Thr Leu Glu Cys Leu Arg Glu Ala Thr Leu Ile Thr Ile Lys His Glu 
        35                  40                  45              


Leu Phe Lys Glu Ala Arg Lys Tyr Pro Leu His Gln Leu Leu Gln Asp 
    50                  55                  60                  


Glu Ser Ser Tyr Ile Phe Val Ser Val Thr Gln Glu Ala Glu Arg Glu 
65                  70                  75                  80  


Glu Phe Phe Asp Glu Thr Arg Arg Leu Cys Asp Leu Arg Leu Phe Gln 
                85                  90                  95      


Pro Phe Leu Lys Val Ile Glu Pro Val Gly Asn Arg Glu Glu Lys Ile 
            100                 105                 110         


Leu Asn Arg Glu Ile Gly Phe Ala Ile Gly Met Pro Val Cys Glu Phe 
        115                 120                 125             


Asp Met Val Lys Asp Pro Glu Val Gln Asp Phe Arg Arg Asn Ile Leu 
    130                 135                 140                 


Asn Val Cys Lys Glu Ala Val Asp Leu Arg Asp Leu Asn Ser Pro His 
145                 150                 155                 160 


Ser Arg Ala Met Tyr Val Tyr Pro Pro Asn Val Glu Ser Ser Pro Glu 
                165                 170                 175     


Leu Pro Lys His Ile Tyr Asn Lys Leu Asp Lys Gly Gln Ile Ile Val 
            180                 185                 190         


Val Ile Trp Val Ile Val Ser Pro Asn Asn Asp Lys Gln Lys Tyr Thr 
        195                 200                 205             


Leu Lys Ile Asn His Asp Cys Val Pro Glu Gln Val Ile Ala Glu Ala 
    210                 215                 220                 


Ile Arg Lys Lys Thr Arg Ser Met Leu Leu Ser Ser Glu Gln Leu Lys 
225                 230                 235                 240 


Leu Cys Val Leu Glu Tyr Gln Gly Lys Tyr Ile Leu Lys Val Cys Gly 
                245                 250                 255     


Cys Asp Glu Tyr Phe Leu Glu Lys Tyr Pro Leu Ser Gln Tyr Lys Tyr 
            260                 265                 270         


Ile Arg Ser Cys Ile Met Leu Gly Arg Met Pro Asn Leu Met Leu Met 
        275                 280                 285             


Ala Lys Glu Ser Leu Tyr Ser Gln Leu Pro Met Asp Cys Phe Thr Met 
    290                 295                 300                 


Pro Ser Tyr Ser Arg Arg Ile Ser Thr Ala Thr Pro Tyr Met Asn Gly 
305                 310                 315                 320 


Glu Thr Ser Thr Lys Ser Leu Trp Val Ile Asn Ser Ala Leu Arg Ile 
                325                 330                 335     


Lys Ile Leu Cys Ala Thr Tyr Val Asn Val Asn Ile Arg Asp Ile Asp 
            340                 345                 350         


Lys Ile Tyr Val Arg Thr Gly Ile Tyr His Gly Gly Glu Pro Leu Cys 
        355                 360                 365             


Asp Asn Val Asn Thr Gln Arg Val Pro Cys Ser Asn Pro Arg Trp Asn 
    370                 375                 380                 


Glu Trp Leu Asn Tyr Asp Ile Tyr Ile Pro Asp Leu Pro Arg Ala Ala 
385                 390                 395                 400 


Arg Leu Cys Leu Ser Ile Cys Ser Val Lys Gly Arg Lys Gly Ala Lys 
                405                 410                 415     


Glu Glu His Cys Pro Leu Ala Trp Gly Asn Ile Asn Leu Phe Asp Tyr 
            420                 425                 430         


Thr Asp Thr Leu Val Ser Gly Lys Met Ala Leu Asn Leu Trp Pro Val 
        435                 440                 445             


Pro His Gly Leu Glu Asp Leu Leu Asn Pro Ile Gly Val Thr Gly Ser 
    450                 455                 460                 


Asn Pro Asn Lys Glu Thr Pro Cys Leu Glu Leu Glu Phe Asp Trp Phe 
465                 470                 475                 480 


Ser Ser Val Val Lys Phe Pro Asp Met Ser Val Ile Glu Glu His Ala 
                485                 490                 495     


Asn Trp Ser Val Ser Arg Glu Ala Gly Phe Ser Tyr Ser His Ala Gly 
            500                 505                 510         


Leu Ser Asn Arg Leu Ala Arg Asp Asn Glu Leu Arg Glu Asn Asp Lys 
        515                 520                 525             


Glu Gln Leu Lys Ala Ile Ser Thr Arg Asp Pro Leu Ser Glu Ile Thr 
    530                 535                 540                 


Glu Gln Glu Lys Asp Phe Leu Trp Ser His Arg His Tyr Cys Val Thr 
545                 550                 555                 560 


Ile Pro Glu Ile Leu Pro Lys Leu Leu Leu Ser Val Lys Trp Asn Ser 
                565                 570                 575     


Arg Asp Glu Val Ala Gln Met Tyr Cys Leu Val Lys Asp Trp Pro Pro 
            580                 585                 590         


Ile Lys Pro Glu Gln Ala Met Glu Leu Leu Asp Cys Asn Tyr Pro Asp 
        595                 600                 605             


Pro Met Val Arg Gly Phe Ala Val Arg Cys Leu Glu Lys Tyr Leu Thr 
    610                 615                 620                 


Asp Asp Lys Leu Ser Gln Tyr Leu Ile Gln Leu Val Gln Val Leu Lys 
625                 630                 635                 640 


Tyr Glu Gln Tyr Leu Asp Asn Leu Leu Val Arg Phe Leu Leu Lys Lys 
                645                 650                 655     


Ala Leu Thr Asn Gln Arg Ile Gly His Phe Phe Phe Trp His Leu Lys 
            660                 665                 670         


Ser Glu Met His Asn Lys Thr Val Ser Gln Arg Phe Gly Leu Leu Leu 
        675                 680                 685             


Glu Ser Tyr Cys Arg Ala Cys Gly Met Tyr Leu Lys His Leu Asn Arg 
    690                 695                 700                 


Gln Val Glu Ala Met Glu Lys Leu Ile Asn Leu Thr Asp Ile Leu Lys 
705                 710                 715                 720 


Gln Glu Lys Lys Asp Glu Thr Gln Lys Val Gln Met Lys Phe Leu Val 
                725                 730                 735     


Glu Gln Met Arg Arg Pro Asp Phe Met Asp Ala Leu Gln Gly Phe Leu 
            740                 745                 750         


Ser Pro Leu Asn Pro Ala His Gln Leu Gly Asn Leu Arg Leu Glu Glu 
        755                 760                 765             


Cys Arg Ile Met Ser Ser Ala Lys Arg Pro Leu Trp Leu Asn Trp Glu 
    770                 775                 780                 


Asn Pro Asp Ile Met Ser Glu Leu Leu Phe Gln Asn Asn Glu Ile Ile 
785                 790                 795                 800 


Phe Lys Asn Gly Asp Asp Leu Arg Gln Asp Met Leu Thr Leu Gln Ile 
                805                 810                 815     


Ile Arg Ile Met Glu Asn Ile Trp Gln Asn Gln Gly Leu Asp Leu Arg 
            820                 825                 830         


Met Leu Pro Tyr Gly Cys Leu Ser Ile Gly Asp Cys Val Gly Leu Ile 
        835                 840                 845             


Glu Val Val Arg Asn Ser His Thr Ile Met Gln Ile Gln Cys Lys Gly 
    850                 855                 860                 


Gly Leu Lys Gly Ala Leu Gln Phe Asn Ser His Thr Leu His Gln Trp 
865                 870                 875                 880 


Leu Lys Asp Lys Asn Lys Gly Glu Ile Tyr Asp Ala Ala Ile Asp Leu 
                885                 890                 895     


Phe Thr Arg Ser Cys Ala Gly Tyr Cys Val Ala Thr Phe Ile Leu Gly 
            900                 905                 910         


Ile Gly Asp Arg His Asn Ser Asn Ile Met Val Lys Asp Asp Gly Gln 
        915                 920                 925             


Leu Phe His Ile Asp Phe Gly His Phe Leu Asp His Lys Lys Lys Lys 
    930                 935                 940                 


Phe Gly Tyr Lys Arg Glu Arg Val Pro Phe Val Leu Thr Gln Asp Phe 
945                 950                 955                 960 


Leu Ile Val Ile Ser Lys Gly Ala Gln Glu Cys Thr Lys Thr Arg Glu 
                965                 970                 975     


Phe Glu Arg Phe Gln Glu Met Cys Tyr Lys Ala Tyr Leu Ala Ile Arg 
            980                 985                 990         


Gln His Ala Asn Leu Phe Ile Asn  Leu Phe Ser Met Met  Leu Gly Ser 
        995                 1000                 1005             


Gly Met  Pro Glu Leu Gln Ser  Phe Asp Asp Ile Ala  Tyr Ile Arg 
    1010                 1015                 1020             


Lys Thr  Leu Ala Leu Asp Lys  Thr Glu Gln Glu Ala  Leu Glu Tyr 
    1025                 1030                 1035             


Phe Met  Lys Gln Met Asn Asp  Ala His His Gly Gly  Trp Thr Thr 
    1040                 1045                 1050             


Lys Met  Asp Trp Ile Phe His  Thr Ile Lys Gln His  Ala Leu Asn 
    1055                 1060                 1065             


<210> 31
<211> 7032
<212> DNA
<213> Homo sapiens

<400> 31
gcggcgccgg gggcgggggg cggcgggcga cggggcgggc gcaggatgag ggcggccatt       60

gctggggctc cgcttcgggg aggaggacgc tgaggaggcg ccgagccgcg cagcgctgcg      120

ggggaggcgc ccgcgccgac gcggggccca tggccaggac caccagccag ctgtatgacg      180

ccgtgcccat ccagtccagc gtggtgttat gttcctgccc atccccatca atggtgagga      240

cccagactga gtccagcacg ccccctggca ttcctggtgg cagcaggcag ggccccgcca      300

tggacggcac tgcagccgag cctcggcccg gcgccggctc cctgcagcat gcccagcctc      360

cgccgcagcc tcggaagaag cggcctgagg acttcaagtt tgggaaaatc cttggggaag      420

gctctttttc cacggttgtc ctggctcgag aactggcaac ctccagagaa tatgcgatta      480

aaattctgga gaagcgacat atcataaaag agaacaaggt cccctatgta accagagagc      540

gggatgtcat gtcgcgcctg gatcacccct tctttgttaa gctttacttc acatttcagg      600

acgacgagaa gctgtatttc ggccttagtt atgccaaaaa tggagaacta cttaaatata      660

ttcgcaaaat cggttcattc gatgagacct gtacccgatt ttacacggct gagattgtgt      720

ctgctttaga gtacttgcac ggcaagggca tcattcacag ggaccttaaa ccggaaaaca      780

ttttgttaaa tgaagatatg cacatccaga tcacagattt tggaacagca aaagtcttat      840

ccccagagag caaacaagcc agggccaact cattcgtggg aacagcgcag tacgtttctc      900

cagagctgct cacggagaag tccgcctgta agagttcaga cctttgggct cttggatgca      960

taatatacca gcttgtggca ggactcccac cattccgagc tggaaacgag tatcttatat     1020

ttcagaagat cattaagttg gaatatgact ttccagaaaa attcttccct aaggcaagag     1080

acctcgtgga gaaacttttg gttttagatg ccacaaagcg gttaggctgt gaggaaatgg     1140

aaggatacgg acctcttaaa gcacacccgt tcttcgagtc cgtcacgtgg gagaacctgc     1200

accagcagac gcctccgaag ctcaccgctt acctgccggc tatgtcggaa gacgacgagg     1260

actgctatgg caattatgac aatctcctga gccagtttgg ctgcatgcag gtgtcttcgt     1320

cctcctcctc acactccctg tcagcctccg acacgggcct gccccagagg tcaggcagca     1380

acatagagca gtacattcac gatctggact cgaactcctt tgaactggac ttacagtttt     1440

ccgaagatga gaagaggttg ttgttggaga agcaggctgg cggaaaccct tgcctaacag     1500

gacgtattat ctgatggacc ccagcgggaa cgcacacaag tggtgcagga agatccagga     1560

ggtttggagg cagcgatacc agagccaccc ggacgccgct gtgcagtgac gtggcctgcg     1620

gccgggctgc ccttcgctgc caggacacct gccccagcgc ggcttggccg ccatccggga     1680

cgcttccaga ccacctgcca gccatcacaa ggggaacgca gaggcggaaa ccttgcagca     1740

tttttattta aaagaaaaga agaaaaaaaa cacccaacca cacaaagaac aaaaccagta     1800

acaaacacaa aggaattcag ggtcgctttg cttgctctct gtgctccgtg gaggcctccg     1860

tgtgccctcg ttgccgtggg gacccagctc catgcacgtc aacccagtcc cgcccagact     1920

agtggacaga cctggtgtca ccagtttttc ctagcatcag tccgaaccat gcgcccgccc     1980

tgccccaact gtgtgctggt cctgctgtgg ccgaggggac cgggtgtgtt tggctcttta     2040

tgcccctccc gctgtggtcc tggaactctt caccagggag ggagccctgc gggggccgca     2100

gctttgtgga gggagccgcc gtgcttctgt cacctgctcc ctttcttgcg tctccctgtg     2160

atgggccctt aggcctggct gggcccatta catatccctg tggtggctct ggtggcagct     2220

ttctgtggcc cctgctgtgt tggcaggcag gtttgcgtgg tgaggagcgg gaggggttgg     2280

agtggtgcgg gagcaggctg ccgagtggag ggtgccatcg agggctccgg atcccttatc     2340

ctacttagca gtgttggtct ctggggctgg aagccgagcg catgctggga gcggtactgt     2400

cagaagtgag cccagttagt accccgctgg ctcactgcac gagagagtcc tgccccgagc     2460

cctaggtggg gccaggaggt gccttggaga agccagccag agcagagagg gctgctgact     2520

tccgtgtgga gcagagaggc ctgagggcct cctaaaaggt ttaaatgtcc acgcctctcc     2580

agttgctgaa gtagggtctg agagaaccct ggcatcagca gacccagggt gcttctgtct     2640

cctgcagacc acgccaggga gtgcagacac caccgtcaca cacgcccctt ttgtgttttg     2700

gttcaagttt ctcagagccc ctcagagctt ctacatctgt gcatcagaaa tctcacagcc     2760

ttctcatgct gccggctcat ctgggcccat agagtgggct ttgccagttg ctgttgcaca     2820

ggaggcgaga acagcacact tcaaccccag cttgctggtc ggctttcctc tagagagagc     2880

cggttttggg gccatttccc tttgatgctt tggtggcctt gccccgctct gcagcacaga     2940

caggccagat gcatttgtcc tttgcctagc tactccccag gtagagagtg ctcctggtgg     3000

cctggcaggt ctgggccctt ctctccctgc ccaggttgtc cctggagggc agccctcact     3060

ccctttgggg gagaggcaga cattgctgcc cacagacctg cctctgactc aactgtgtcc     3120

accctccctg gtccctaccc ccaagtcaca ggtgactcag cagtgaccct gtgtgccagg     3180

ccagatccaa actgagaggg aaggtgtcgt ttttacactg ctaatgacga gagtggctct     3240

ttttagctag gcgagtacag acggggcctg ggagggggca gagatgttcc ccaggccctg     3300

cctgtggttc ctgcctgggc cttggctgct gctgtgtgag agctgcatgt gagcctgtga     3360

ccgtgagctg gggtgagctg ggccgcacct accctggggc cccagggagc aggacgctcc     3420

ggggcccagc acgttgccct gggcctgtgg ccggagtcgg agtcctctct cctcctcctg     3480

gcttttggaa aggcttggct gtgttgggga gtctctctta gccctttcag gaatttctgt     3540

tcaggcttcc tcctcctcat cagctatttt acccatctca gaacgtcctg tgtctccatg     3600

taggagagtg gctctctcag atctctcagg gcgtctggtt atagggaaac aagtggagca     3660

gggacgtggc tttaattgga gcactcggct gggctgcttg gggagactct tccgtgcgtt     3720

cttcctctgg atagaaccac cacctcctgg gcgtcactga caagctccat cttaacctcc     3780

aaagccacag aactaggggc tcagagccag agctggcagc cgccagccaa aatgatgcca     3840

ttgcctgagc tgacagccaa gcccttctgt gggtcacctt tctcctcacc cagccccttg     3900

ctcttccctt ttgaaaggcc cgtgtgtttt ctttccttac cctgtgcttg ctcatgtcta     3960

ctccggtttt ctctaccaca tccttagagc catcacctgg cacgcaggcg ccttacattc     4020

tacggtagaa cgtggggtac tgtgtgtgca catagacaca cttacgtgga attacagttg     4080

tgggtttatc caagatgagg aagatttcac ctgctgttta atagacttgg ggccatgtgc     4140

ctccccacac atgggcaagg acaggtggaa tgtcgggacc acactgtgcg gcttctcggc     4200

acaaagcgga gggaggctgt ggtcgctgcc ggcctaggtg tcccaggtgc cccgcctttc     4260

tctgggacac agttgggggc tggcttctga gggattcctt tctcccctct ttgtgtggcc     4320

ccagccaggg cggtgggcag tcctggtgta gagcacaagc ctctccaccc tagagaaatg     4380

cctctgtacc acggctacca tgtggaacct taacttgcag aaggcttgtt aacaattgtt     4440

ttgagagaga tggctggtca tgccacagct gctggggact ccgcctactc cagccctctt     4500

gggacacact gtgggatttg tggcccttcc ccagaggaat tgtggagact gtcccatgga     4560

acaaaccctc aggcaccagc acagggctct gggtgactca gtaaaactaa cgtttgtctc     4620

tgacaagatc agctgtaggc tcaccggcca gagaagacca ctgtgagcat tttgccgtat     4680

atcctgccct gccatttgtt cactttttaa actaaaatag gaacatccga cacacaccgt     4740

ttgcatcgtc ttctcccttg atattttaag cattttccca tgtcatgagt ttctcagaaa     4800

catgttttta acaattgtac tatttagtca ttgtccattt actataattt atctgaccat     4860

ttccctactg taaaatactt aagacggttt ctgatttttc cactatttaa ataatgctgt     4920

gatgaatatc tttaaaatct tctgatttct tacttttttc ccccttagat gcctggaagt     4980

ggtattttga ggtgaaagag tttgttcatt ttgaagatat ttctgtctct ctctcgacct     5040

gatgtgtaga cgctcacttc cagtagcaga accaccttag ttgtgtctta cagattctga     5100

acaaatcggt ttctgataag ccatgtgttc caaagaatgt ctgaataaga ccgctcttta     5160

tttaaatgct aagaggatgt cactactgca atccatctgt ggccgatttt ttccaagagc     5220

caatttcctt gttttggttg caagaacctg gctctgcctg catgtcagct ctctgccctc     5280

cctgctgccg tggctttcaa gcgcttggca gaatcttgta cttcgtgtcc acaatggtac     5340

tgaatttgca tctgcacagt cagcagagat aacaagtgtt gaactgacct tgccacatgc     5400

ttagtgagtg atttgtaatt aagtttatag actcagaagg tatattagga catttggaat     5460

cagtagcaga gcaaagcctc tttgaaaaaa accacgtagc tgattgggtt ttacaagagt     5520

gcatttgtct cccccttcca cccgtggggc cccaccttca ggtcttagtg gttcacaaga     5580

gcccagcagc caggctggct ttttcattgt agggcgtggt tgtcccagct ggtgtagatt     5640

tcaggccgcc ccccccaact ccctgcccac agtgttgcag attgcctggc tggcagcaag     5700

tccagaccac ccaaatttgg ttggattctt catttctcca ctgtagttgg ggtccattga     5760

ttgtgcaggg gaacgtgcag gaggtttttc taggcaccgt gttcagtgct gcttcactct     5820

accagagatt atggccaaat tgcacggaat ttggtttctt gccctctgaa gcctgagggc     5880

ccccccttgc ctggctggtt gacagacccg gggtggtcac tgctgagact tcagagatcg     5940

cagctgctgt gagaatacgg tgaaggtact ttgttctgga agatgttgtc atacactttt     6000

ccccagttat tttcaaactt gacatgagcc tatgttgact cactgggtgg gggtcccttc     6060

ttacgcagca cacgtggcaa gtgcctgaat cggggctgga ggcacttcag agcctctgag     6120

gggccaccac ttctggccca aaattgcagg gttgtagatg aggctgcctg tggagaactg     6180

gtgtgaggag gaagctgttt ccaacaaaga gcactttcat ctgttgagat ggctgtggtg     6240

agcaactgaa cgagcctacg tgtgtacctg aattttcccc gtaactcatt tcttccatat     6300

gaagaaacac caaactatgt acagagaact ttttacaaaa ggcagacctt ttttaagctg     6360

tgtaacccac atagcctaac cacctggcag aatgactacg aataggggtc attgtgctgg     6420

taaaagcctc tattacgact gtaagtaagt tggatgttgg caaaattaaa ttgttacagt     6480

atttagagct gctgtagctg ttccttcaca acataaaata ggataaatga ctagtacgtc     6540

tttcaggtgg gtggcaagca gaacatgcgt aatattctct acctggtctg tagctgtaac     6600

tgtgatgtac agacaaagca aaaattaaaa gaacttatga aaacaaatgc aatgatacta     6660

ggatatacac ttttgtattt ttattcttat ataaggttat ttgctggcta ttgttggcct     6720

ctagttcagt ctgtgttatt taaattctaa tatatgaatt atttgaattg aattcatgtt     6780

cggggccacg ttgttgtatg tattgatgta cagccttgaa tgtgaataat tattgtaaac     6840

tatattttac aacttttttt ctggctttat tatataaatt ttctattggg tcagtgattt     6900

aatcatataa tttaatgaat ctgtttatcc tttttttttt tccaaatact tgtgctttag     6960

gtgtagttac cagatgatga attttcctcg tatggtcagt agtcttgtaa taaaaagcat     7020

gtagagtgta ga                                                         7032


<210> 32
<211> 7243
<212> DNA
<213> Homo sapiens

<400> 32
gcggcgccgg gggcgggggg cggcgggcga cggggcgggc gcaggatgag ggcggccatt       60

gctggggctc cgcttcgggg aggaggacgc tgaggaggcg ccgagccgcg cagcgctgcg      120

ggggaggcgc ccgcgccgac gcggggccca tggccaggac caccagccag ctgtatgacg      180

ccgtgcccat ccagtccagc gtggtgttat gttcctgccc atccccatca atggtgagga      240

cccagactga gtccagcacg ccccctggca ttcctggtgg cagcaggcag ggccccgcca      300

tggacggcac tgcagccgag cctcggcccg gcgccggctc cctgcagcat gcccagcctc      360

cgccgcagcc tcggaagaag cggcctgagg acttcaagtt tgggaaaatc cttggggaag      420

gctctttttc cacggttgtc ctggctcgag aactggcaac ctccagagaa tatgcgatta      480

aaattctgga gaagcgacat atcataaaag agaacaaggt cccctatgta accagagagc      540

gggatgtcat gtcgcgcctg gatcacccct tctttgttaa gctttacttc acatttcagg      600

acgacgagaa gctgtatttc ggccttagtt atgccaaaaa tggagaacta cttaaatata      660

ttcgcaaaat cggttcattc gatgagacct gtacccgatt ttacacggct gagattgtgt      720

ctgctttaga gtacttgcac ggcaagggca tcattcacag ggaccttaaa ccggaaaaca      780

ttttgttaaa tgaagatatg cacatccaga tcacagattt tggaacagca aaagtcttat      840

ccccagagag caaacaagcc agggccaact cattcgtggg aacagcgcag tacgtttctc      900

cagagctgct cacggagaag tccgcctgta agagttcaga cctttgggct cttggatgca      960

taatatacca gcttgtggca ggactcccac cattccgagc tggaaacgag tatcttatat     1020

ttcagaagat cattaagttg gaatatgact ttccagaaaa attcttccct aaggcaagag     1080

acctcgtgga gaaacttttg gttttagatg ccacaaagcg gttaggctgt gaggaaatgg     1140

aaggatacgg acctcttaaa gcacacccgt tcttcgagtc cgtcacgtgg gagaacctgc     1200

accagcagac gcctccgaag ctcaccgctt acctgccggc tatgtcggaa gacgacgagg     1260

actgctatgg caattatgac aatctcctga gccagtttgg ctgcatgcag gtgtcttcgt     1320

cctcctcctc acactccctg tcagcctccg acacgggcct gccccagagg tcaggcagca     1380

acatagagca gtacattcac gatctggact cgaactcctt tgaactggac ttacagtttt     1440

ccgaagatga gaagaggttg ttgttggaga agcaggctgg cggaaaccct tggcaccagt     1500

ttgtagaaaa taatttaata ctaaagatgg gcccagtgga taagcggaag ggtttatttg     1560

caagacgacg acagctgttg ctcacagaag gaccacattt atattatgtg gatcctgtca     1620

acaaagttct gaaaggtgaa attccttggt cacaagaact tcgaccagag gccaagaatt     1680

ttaaaacttt ctttgtccac acgcctaaca ggacgtatta tctgatggac cccagcggga     1740

acgcacacaa gtggtgcagg aagatccagg aggtttggag gcagcgatac cagagccacc     1800

cggacgccgc tgtgcagtga cgtggcctgc ggccgggctg cccttcgctg ccaggacacc     1860

tgccccagcg cggcttggcc gccatccggg acgcttccag accacctgcc agccatcaca     1920

aggggaacgc agaggcggaa accttgcagc atttttattt aaaagaaaag aagaaaaaaa     1980

acacccaacc acacaaagaa caaaaccagt aacaaacaca aaggaattca gggtcgcttt     2040

gcttgctctc tgtgctccgt ggaggcctcc gtgtgccctc gttgccgtgg ggacccagct     2100

ccatgcacgt caacccagtc ccgcccagac tagtggacag acctggtgtc accagttttt     2160

cctagcatca gtccgaacca tgcgcccgcc ctgccccaac tgtgtgctgg tcctgctgtg     2220

gccgagggga ccgggtgtgt ttggctcttt atgcccctcc cgctgtggtc ctggaactct     2280

tcaccaggga gggagccctg cgggggccgc agctttgtgg agggagccgc cgtgcttctg     2340

tcacctgctc cctttcttgc gtctccctgt gatgggccct taggcctggc tgggcccatt     2400

acatatccct gtggtggctc tggtggcagc tttctgtggc ccctgctgtg ttggcaggca     2460

ggtttgcgtg gtgaggagcg ggaggggttg gagtggtgcg ggagcaggct gccgagtgga     2520

gggtgccatc gagggctccg gatcccttat cctacttagc agtgttggtc tctggggctg     2580

gaagccgagc gcatgctggg agcggtactg tcagaagtga gcccagttag taccccgctg     2640

gctcactgca cgagagagtc ctgccccgag ccctaggtgg ggccaggagg tgccttggag     2700

aagccagcca gagcagagag ggctgctgac ttccgtgtgg agcagagagg cctgagggcc     2760

tcctaaaagg tttaaatgtc cacgcctctc cagttgctga agtagggtct gagagaaccc     2820

tggcatcagc agacccaggg tgcttctgtc tcctgcagac cacgccaggg agtgcagaca     2880

ccaccgtcac acacgcccct tttgtgtttt ggttcaagtt tctcagagcc cctcagagct     2940

tctacatctg tgcatcagaa atctcacagc cttctcatgc tgccggctca tctgggccca     3000

tagagtgggc tttgccagtt gctgttgcac aggaggcgag aacagcacac ttcaacccca     3060

gcttgctggt cggctttcct ctagagagag ccggttttgg ggccatttcc ctttgatgct     3120

ttggtggcct tgccccgctc tgcagcacag acaggccaga tgcatttgtc ctttgcctag     3180

ctactcccca ggtagagagt gctcctggtg gcctggcagg tctgggccct tctctccctg     3240

cccaggttgt ccctggaggg cagccctcac tccctttggg ggagaggcag acattgctgc     3300

ccacagacct gcctctgact caactgtgtc caccctccct ggtccctacc cccaagtcac     3360

aggtgactca gcagtgaccc tgtgtgccag gccagatcca aactgagagg gaaggtgtcg     3420

tttttacact gctaatgacg agagtggctc tttttagcta ggcgagtaca gacggggcct     3480

gggagggggc agagatgttc cccaggccct gcctgtggtt cctgcctggg ccttggctgc     3540

tgctgtgtga gagctgcatg tgagcctgtg accgtgagct ggggtgagct gggccgcacc     3600

taccctgggg ccccagggag caggacgctc cggggcccag cacgttgccc tgggcctgtg     3660

gccggagtcg gagtcctctc tcctcctcct ggcttttgga aaggcttggc tgtgttgggg     3720

agtctctctt agccctttca ggaatttctg ttcaggcttc ctcctcctca tcagctattt     3780

tacccatctc agaacgtcct gtgtctccat gtaggagagt ggctctctca gatctctcag     3840

ggcgtctggt tatagggaaa caagtggagc agggacgtgg ctttaattgg agcactcggc     3900

tgggctgctt ggggagactc ttccgtgcgt tcttcctctg gatagaacca ccacctcctg     3960

ggcgtcactg acaagctcca tcttaacctc caaagccaca gaactagggg ctcagagcca     4020

gagctggcag ccgccagcca aaatgatgcc attgcctgag ctgacagcca agcccttctg     4080

tgggtcacct ttctcctcac ccagcccctt gctcttccct tttgaaaggc ccgtgtgttt     4140

tctttcctta ccctgtgctt gctcatgtct actccggttt tctctaccac atccttagag     4200

ccatcacctg gcacgcaggc gccttacatt ctacggtaga acgtggggta ctgtgtgtgc     4260

acatagacac acttacgtgg aattacagtt gtgggtttat ccaagatgag gaagatttca     4320

cctgctgttt aatagacttg gggccatgtg cctccccaca catgggcaag gacaggtgga     4380

atgtcgggac cacactgtgc ggcttctcgg cacaaagcgg agggaggctg tggtcgctgc     4440

cggcctaggt gtcccaggtg ccccgccttt ctctgggaca cagttggggg ctggcttctg     4500

agggattcct ttctcccctc tttgtgtggc cccagccagg gcggtgggca gtcctggtgt     4560

agagcacaag cctctccacc ctagagaaat gcctctgtac cacggctacc atgtggaacc     4620

ttaacttgca gaaggcttgt taacaattgt tttgagagag atggctggtc atgccacagc     4680

tgctggggac tccgcctact ccagccctct tgggacacac tgtgggattt gtggcccttc     4740

cccagaggaa ttgtggagac tgtcccatgg aacaaaccct caggcaccag cacagggctc     4800

tgggtgactc agtaaaacta acgtttgtct ctgacaagat cagctgtagg ctcaccggcc     4860

agagaagacc actgtgagca ttttgccgta tatcctgccc tgccatttgt tcacttttta     4920

aactaaaata ggaacatccg acacacaccg tttgcatcgt cttctccctt gatattttaa     4980

gcattttccc atgtcatgag tttctcagaa acatgttttt aacaattgta ctatttagtc     5040

attgtccatt tactataatt tatctgacca tttccctact gtaaaatact taagacggtt     5100

tctgattttt ccactattta aataatgctg tgatgaatat ctttaaaatc ttctgatttc     5160

ttactttttt cccccttaga tgcctggaag tggtattttg aggtgaaaga gtttgttcat     5220

tttgaagata tttctgtctc tctctcgacc tgatgtgtag acgctcactt ccagtagcag     5280

aaccacctta gttgtgtctt acagattctg aacaaatcgg tttctgataa gccatgtgtt     5340

ccaaagaatg tctgaataag accgctcttt atttaaatgc taagaggatg tcactactgc     5400

aatccatctg tggccgattt tttccaagag ccaatttcct tgttttggtt gcaagaacct     5460

ggctctgcct gcatgtcagc tctctgccct ccctgctgcc gtggctttca agcgcttggc     5520

agaatcttgt acttcgtgtc cacaatggta ctgaatttgc atctgcacag tcagcagaga     5580

taacaagtgt tgaactgacc ttgccacatg cttagtgagt gatttgtaat taagtttata     5640

gactcagaag gtatattagg acatttggaa tcagtagcag agcaaagcct ctttgaaaaa     5700

aaccacgtag ctgattgggt tttacaagag tgcatttgtc tcccccttcc acccgtgggg     5760

ccccaccttc aggtcttagt ggttcacaag agcccagcag ccaggctggc tttttcattg     5820

tagggcgtgg ttgtcccagc tggtgtagat ttcaggccgc cccccccaac tccctgccca     5880

cagtgttgca gattgcctgg ctggcagcaa gtccagacca cccaaatttg gttggattct     5940

tcatttctcc actgtagttg gggtccattg attgtgcagg ggaacgtgca ggaggttttt     6000

ctaggcaccg tgttcagtgc tgcttcactc taccagagat tatggccaaa ttgcacggaa     6060

tttggtttct tgccctctga agcctgaggg cccccccttg cctggctggt tgacagaccc     6120

ggggtggtca ctgctgagac ttcagagatc gcagctgctg tgagaatacg gtgaaggtac     6180

tttgttctgg aagatgttgt catacacttt tccccagtta ttttcaaact tgacatgagc     6240

ctatgttgac tcactgggtg ggggtccctt cttacgcagc acacgtggca agtgcctgaa     6300

tcggggctgg aggcacttca gagcctctga ggggccacca cttctggccc aaaattgcag     6360

ggttgtagat gaggctgcct gtggagaact ggtgtgagga ggaagctgtt tccaacaaag     6420

agcactttca tctgttgaga tggctgtggt gagcaactga acgagcctac gtgtgtacct     6480

gaattttccc cgtaactcat ttcttccata tgaagaaaca ccaaactatg tacagagaac     6540

tttttacaaa aggcagacct tttttaagct gtgtaaccca catagcctaa ccacctggca     6600

gaatgactac gaataggggt cattgtgctg gtaaaagcct ctattacgac tgtaagtaag     6660

ttggatgttg gcaaaattaa attgttacag tatttagagc tgctgtagct gttccttcac     6720

aacataaaat aggataaatg actagtacgt ctttcaggtg ggtggcaagc agaacatgcg     6780

taatattctc tacctggtct gtagctgtaa ctgtgatgta cagacaaagc aaaaattaaa     6840

agaacttatg aaaacaaatg caatgatact aggatataca cttttgtatt tttattctta     6900

tataaggtta tttgctggct attgttggcc tctagttcag tctgtgttat ttaaattcta     6960

atatatgaat tatttgaatt gaattcatgt tcggggccac gttgttgtat gtattgatgt     7020

acagccttga atgtgaataa ttattgtaaa ctatatttta caactttttt tctggcttta     7080

ttatataaat tttctattgg gtcagtgatt taatcatata atttaatgaa tctgtttatc     7140

cttttttttt ttccaaatac ttgtgcttta ggtgtagtta ccagatgatg aattttcctc     7200

gtatggtcag tagtcttgta ataaaaagca tgtagagtgt aga                       7243


<210> 33
<211> 6862
<212> DNA
<213> Homo sapiens

<400> 33
gcggcgccgg gggcgggggg cggcgggcga cggggcgggc gcaggatgag ggcggccatt       60

gctggggctc cgcttcgggg aggaggacgc tgaggaggcg ccgagccgcg cagcgctgcg      120

ggggaggcgc ccgcgccgac gcggggccca tggccaggac caccagccag ctgtatgacg      180

ccgtgcccat ccagtccagc gtggtgttat gttcctgccc atccccatca atggtgagga      240

cccagactga gtccagcacg ccccctggca ttcctggtgg cagcaggcag ggccccgcca      300

tggacggcac tgcagccgag cctcggcccg gcgccggctc cctgcagcat gcccagcctc      360

cgccgcagcc tcggaagaag cggcctgagg acttcaagtt tgggaaaatc cttggggaag      420

gctctttttc cacggttgtc ctggctcgag aactggcaac ctccagagaa tatgcgacca      480

gggccaactc attcgtggga acagcgcagt acgtttctcc agagctgctc acggagaagt      540

ccgcctgtaa gagttcagac ctttgggctc ttggatgcat aatataccag cttgtggcag      600

gactcccacc attccgagct ggaaacgagt atcttatatt tcagaagatc attaagttgg      660

aatatgactt tccagaaaaa ttcttcccta aggcaagaga cctcgtggag aaacttttgg      720

ttttagatgc cacaaagcgg ttaggctgtg aggaaatgga aggatacgga cctcttaaag      780

cacacccgtt cttcgagtcc gtcacgtggg agaacctgca ccagcagacg cctccgaagc      840

tcaccgctta cctgccggct atgtcggaag acgacgagga ctgctatggc aattatgaca      900

atctcctgag ccagtttggc tgcatgcagg tgtcttcgtc ctcctcctca cactccctgt      960

cagcctccga cacgggcctg ccccagaggt caggcagcaa catagagcag tacattcacg     1020

atctggactc gaactccttt gaactggact tacagttttc cgaagatgag aagaggttgt     1080

tgttggagaa gcaggctggc ggaaaccctt ggcaccagtt tgtagaaaat aatttaatac     1140

taaagatggg cccagtggat aagcggaagg gtttatttgc aagacgacga cagctgttgc     1200

tcacagaagg accacattta tattatgtgg atcctgtcaa caaagttctg aaaggtgaaa     1260

ttccttggtc acaagaactt cgaccagagg ccaagaattt taaaactttc tttgtccaca     1320

cgcctaacag gacgtattat ctgatggacc ccagcgggaa cgcacacaag tggtgcagga     1380

agatccagga ggtttggagg cagcgatacc agagccaccc ggacgccgct gtgcagtgac     1440

gtggcctgcg gccgggctgc ccttcgctgc caggacacct gccccagcgc ggcttggccg     1500

ccatccggga cgcttccaga ccacctgcca gccatcacaa ggggaacgca gaggcggaaa     1560

ccttgcagca tttttattta aaagaaaaga agaaaaaaaa cacccaacca cacaaagaac     1620

aaaaccagta acaaacacaa aggaattcag ggtcgctttg cttgctctct gtgctccgtg     1680

gaggcctccg tgtgccctcg ttgccgtggg gacccagctc catgcacgtc aacccagtcc     1740

cgcccagact agtggacaga cctggtgtca ccagtttttc ctagcatcag tccgaaccat     1800

gcgcccgccc tgccccaact gtgtgctggt cctgctgtgg ccgaggggac cgggtgtgtt     1860

tggctcttta tgcccctccc gctgtggtcc tggaactctt caccagggag ggagccctgc     1920

gggggccgca gctttgtgga gggagccgcc gtgcttctgt cacctgctcc ctttcttgcg     1980

tctccctgtg atgggccctt aggcctggct gggcccatta catatccctg tggtggctct     2040

ggtggcagct ttctgtggcc cctgctgtgt tggcaggcag gtttgcgtgg tgaggagcgg     2100

gaggggttgg agtggtgcgg gagcaggctg ccgagtggag ggtgccatcg agggctccgg     2160

atcccttatc ctacttagca gtgttggtct ctggggctgg aagccgagcg catgctggga     2220

gcggtactgt cagaagtgag cccagttagt accccgctgg ctcactgcac gagagagtcc     2280

tgccccgagc cctaggtggg gccaggaggt gccttggaga agccagccag agcagagagg     2340

gctgctgact tccgtgtgga gcagagaggc ctgagggcct cctaaaaggt ttaaatgtcc     2400

acgcctctcc agttgctgaa gtagggtctg agagaaccct ggcatcagca gacccagggt     2460

gcttctgtct cctgcagacc acgccaggga gtgcagacac caccgtcaca cacgcccctt     2520

ttgtgttttg gttcaagttt ctcagagccc ctcagagctt ctacatctgt gcatcagaaa     2580

tctcacagcc ttctcatgct gccggctcat ctgggcccat agagtgggct ttgccagttg     2640

ctgttgcaca ggaggcgaga acagcacact tcaaccccag cttgctggtc ggctttcctc     2700

tagagagagc cggttttggg gccatttccc tttgatgctt tggtggcctt gccccgctct     2760

gcagcacaga caggccagat gcatttgtcc tttgcctagc tactccccag gtagagagtg     2820

ctcctggtgg cctggcaggt ctgggccctt ctctccctgc ccaggttgtc cctggagggc     2880

agccctcact ccctttgggg gagaggcaga cattgctgcc cacagacctg cctctgactc     2940

aactgtgtcc accctccctg gtccctaccc ccaagtcaca ggtgactcag cagtgaccct     3000

gtgtgccagg ccagatccaa actgagaggg aaggtgtcgt ttttacactg ctaatgacga     3060

gagtggctct ttttagctag gcgagtacag acggggcctg ggagggggca gagatgttcc     3120

ccaggccctg cctgtggttc ctgcctgggc cttggctgct gctgtgtgag agctgcatgt     3180

gagcctgtga ccgtgagctg gggtgagctg ggccgcacct accctggggc cccagggagc     3240

aggacgctcc ggggcccagc acgttgccct gggcctgtgg ccggagtcgg agtcctctct     3300

cctcctcctg gcttttggaa aggcttggct gtgttgggga gtctctctta gccctttcag     3360

gaatttctgt tcaggcttcc tcctcctcat cagctatttt acccatctca gaacgtcctg     3420

tgtctccatg taggagagtg gctctctcag atctctcagg gcgtctggtt atagggaaac     3480

aagtggagca gggacgtggc tttaattgga gcactcggct gggctgcttg gggagactct     3540

tccgtgcgtt cttcctctgg atagaaccac cacctcctgg gcgtcactga caagctccat     3600

cttaacctcc aaagccacag aactaggggc tcagagccag agctggcagc cgccagccaa     3660

aatgatgcca ttgcctgagc tgacagccaa gcccttctgt gggtcacctt tctcctcacc     3720

cagccccttg ctcttccctt ttgaaaggcc cgtgtgtttt ctttccttac cctgtgcttg     3780

ctcatgtcta ctccggtttt ctctaccaca tccttagagc catcacctgg cacgcaggcg     3840

ccttacattc tacggtagaa cgtggggtac tgtgtgtgca catagacaca cttacgtgga     3900

attacagttg tgggtttatc caagatgagg aagatttcac ctgctgttta atagacttgg     3960

ggccatgtgc ctccccacac atgggcaagg acaggtggaa tgtcgggacc acactgtgcg     4020

gcttctcggc acaaagcgga gggaggctgt ggtcgctgcc ggcctaggtg tcccaggtgc     4080

cccgcctttc tctgggacac agttgggggc tggcttctga gggattcctt tctcccctct     4140

ttgtgtggcc ccagccaggg cggtgggcag tcctggtgta gagcacaagc ctctccaccc     4200

tagagaaatg cctctgtacc acggctacca tgtggaacct taacttgcag aaggcttgtt     4260

aacaattgtt ttgagagaga tggctggtca tgccacagct gctggggact ccgcctactc     4320

cagccctctt gggacacact gtgggatttg tggcccttcc ccagaggaat tgtggagact     4380

gtcccatgga acaaaccctc aggcaccagc acagggctct gggtgactca gtaaaactaa     4440

cgtttgtctc tgacaagatc agctgtaggc tcaccggcca gagaagacca ctgtgagcat     4500

tttgccgtat atcctgccct gccatttgtt cactttttaa actaaaatag gaacatccga     4560

cacacaccgt ttgcatcgtc ttctcccttg atattttaag cattttccca tgtcatgagt     4620

ttctcagaaa catgttttta acaattgtac tatttagtca ttgtccattt actataattt     4680

atctgaccat ttccctactg taaaatactt aagacggttt ctgatttttc cactatttaa     4740

ataatgctgt gatgaatatc tttaaaatct tctgatttct tacttttttc ccccttagat     4800

gcctggaagt ggtattttga ggtgaaagag tttgttcatt ttgaagatat ttctgtctct     4860

ctctcgacct gatgtgtaga cgctcacttc cagtagcaga accaccttag ttgtgtctta     4920

cagattctga acaaatcggt ttctgataag ccatgtgttc caaagaatgt ctgaataaga     4980

ccgctcttta tttaaatgct aagaggatgt cactactgca atccatctgt ggccgatttt     5040

ttccaagagc caatttcctt gttttggttg caagaacctg gctctgcctg catgtcagct     5100

ctctgccctc cctgctgccg tggctttcaa gcgcttggca gaatcttgta cttcgtgtcc     5160

acaatggtac tgaatttgca tctgcacagt cagcagagat aacaagtgtt gaactgacct     5220

tgccacatgc ttagtgagtg atttgtaatt aagtttatag actcagaagg tatattagga     5280

catttggaat cagtagcaga gcaaagcctc tttgaaaaaa accacgtagc tgattgggtt     5340

ttacaagagt gcatttgtct cccccttcca cccgtggggc cccaccttca ggtcttagtg     5400

gttcacaaga gcccagcagc caggctggct ttttcattgt agggcgtggt tgtcccagct     5460

ggtgtagatt tcaggccgcc ccccccaact ccctgcccac agtgttgcag attgcctggc     5520

tggcagcaag tccagaccac ccaaatttgg ttggattctt catttctcca ctgtagttgg     5580

ggtccattga ttgtgcaggg gaacgtgcag gaggtttttc taggcaccgt gttcagtgct     5640

gcttcactct accagagatt atggccaaat tgcacggaat ttggtttctt gccctctgaa     5700

gcctgagggc ccccccttgc ctggctggtt gacagacccg gggtggtcac tgctgagact     5760

tcagagatcg cagctgctgt gagaatacgg tgaaggtact ttgttctgga agatgttgtc     5820

atacactttt ccccagttat tttcaaactt gacatgagcc tatgttgact cactgggtgg     5880

gggtcccttc ttacgcagca cacgtggcaa gtgcctgaat cggggctgga ggcacttcag     5940

agcctctgag gggccaccac ttctggccca aaattgcagg gttgtagatg aggctgcctg     6000

tggagaactg gtgtgaggag gaagctgttt ccaacaaaga gcactttcat ctgttgagat     6060

ggctgtggtg agcaactgaa cgagcctacg tgtgtacctg aattttcccc gtaactcatt     6120

tcttccatat gaagaaacac caaactatgt acagagaact ttttacaaaa ggcagacctt     6180

ttttaagctg tgtaacccac atagcctaac cacctggcag aatgactacg aataggggtc     6240

attgtgctgg taaaagcctc tattacgact gtaagtaagt tggatgttgg caaaattaaa     6300

ttgttacagt atttagagct gctgtagctg ttccttcaca acataaaata ggataaatga     6360

ctagtacgtc tttcaggtgg gtggcaagca gaacatgcgt aatattctct acctggtctg     6420

tagctgtaac tgtgatgtac agacaaagca aaaattaaaa gaacttatga aaacaaatgc     6480

aatgatacta ggatatacac ttttgtattt ttattcttat ataaggttat ttgctggcta     6540

ttgttggcct ctagttcagt ctgtgttatt taaattctaa tatatgaatt atttgaattg     6600

aattcatgtt cggggccacg ttgttgtatg tattgatgta cagccttgaa tgtgaataat     6660

tattgtaaac tatattttac aacttttttt ctggctttat tatataaatt ttctattggg     6720

tcagtgattt aatcatataa tttaatgaat ctgtttatcc tttttttttt tccaaatact     6780

tgtgctttag gtgtagttac cagatgatga attttcctcg tatggtcagt agtcttgtaa     6840

taaaaagcat gtagagtgta ga                                              6862


<210> 34
<211> 3208
<212> DNA
<213> Homo sapiens

<400> 34
agatattcat gaaccgttgc ttcttccagc ctcgccttct cgctccctct gcctttctgg       60

cgctgttctc cctccctccc tctggcttct gctctttctt actccttctc tcagctgctt      120

aactacagct cccactggaa cttgcacaat caaaaacaac tctcctctct caagccgcct      180

ccaggagcgc atcacctgga gaagagcgac tcgctccccg cgccggccgc ggaagagcag      240

ccaggtagct gggggcgggg aggcgtaccc ttctcccgct cggtaagagc cacagcatct      300

ccccggagat tggccgtatc ccaccgtccg gcccccaggg tcctgcagcg gtgatgcata      360

tgtttcggag caatgatgga aggagaaaag ccgctgtcgg tggcaactga aagtggggag      420

aggttgctgc agtagctggt gctgcagaat gcgcgagtga agaactgagc cccgctagat      480

tctccatccc gctcagtctt cattaactgt ctgcaggagg taaaccgggg aaacagatat      540

gcactaacca ggcgggtgcc aacctggatc tataactgtg aattccccac ggtggaaaat      600

ggtaaacaaa gacatgaatg gattcccagt caagaaatgc tcagccttcc aattttttaa      660

gaagcgggta cgaaggtgga tcaagagccc aatggtcagt gtggacaagc atcagagtcc      720

cagcctgaag tacaccggct cctccatggt gcacatccct ccaggggagc cagacttcga      780

gtcttccttg tgtcaaacat gcctgggtga acatgctttc caaagagggg ttctccctca      840

ggagaacgag tcatgttcat gggaaactca atctgggtgt gaagtgagag agccatgtaa      900

tcatgccaac atcctgacca agcccgatcc aagaaccttc tggactaatg atgatccagc      960

tttcatgaag cagaggagga tgggtctgaa cgactttatt cagaagattg ccaataactc     1020

ctatgcatgc aaacaccctg aagttcagtc catcttgaag atctcccaac ctcaggagcc     1080

tgagcttatg aatgccaacc cttctcctcc accaagtcct tctcagcaaa tcaaccttgg     1140

cccgtcgtcc aatcctcatg ctaaaccatc tgactttcac ttcttgaaag tgatcggaaa     1200

gggcagtttt ggaaaggttc ttctagcaag acacaaggca gaagaagtgt tctatgcagt     1260

caaagtttta cagaagaaag caatcctgaa aaagaaagag gagaagcata ttatgtcgga     1320

gcggaatgtt ctgttgaaga atgtgaagca ccctttcctg gtgggccttc acttctcttt     1380

ccagactgct gacaaattgt actttgtcct agactacatt aatggtggag agttgttcta     1440

ccatctccag agggaacgct gcttcctgga accacgggct cgtttctatg ctgctgaaat     1500

agccagtgcc ttgggctacc tgcattcact gaacatcgtt tatagagact taaaaccaga     1560

gaatattttg ctagattcac agggacacat tgtccttact gacttcggac tctgcaagga     1620

gaacattgaa cacaacagca caacatccac cttctgtggc acgccggagt atctcgcacc     1680

tgaggtgctt cataagcagc cttatgacag gactgtggac tggtggtgcc tgggagctgt     1740

cttgtatgag atgctgtatg gcctgccgcc tttttatagc cgaaacacag ctgaaatgta     1800

cgacaacatt ctgaacaagc ctctccagct gaaaccaaat attacaaatt ccgcaagaca     1860

cctcctggag ggcctcctgc agaaggacag gacaaagcgg ctcggggcca aggatgactt     1920

catggagatt aagagtcatg tcttcttctc cttaattaac tgggatgatc tcattaataa     1980

gaagattact ccccctttta acccaaatgt gagtgggccc aacgacctac ggcactttga     2040

ccccgagttt accgaagagc ctgtccccaa ctccattggc aagtcccctg acagcgtcct     2100

cgtcacagcc agcgtcaagg aagctgccga ggctttccta ggcttttcct atgcgcctcc     2160

cacggactct ttcctctgaa ccctgttagg gcttggtttt aaaggatttt atgtgtgttt     2220

ccgaatgttt tagttagcct tttggtggag ccgccagctg acaggacatc ttacaagaga     2280

atttgcacat ctctggaagc ttagcaatct tattgcacac tgttcgctgg aagctttttg     2340

aagagcacat tctcctcagt gagctcatga ggttttcatt tttattcttc cttccaacgt     2400

ggtgctatct ctgaaacgag cgttagagtg ccgccttaga cggaggcagg agtttcgtta     2460

gaaagcggac gctgttctaa aaaaggtctc ctgcagatct gtctgggctg tgatgacgaa     2520

tattatgaaa tgtgcctttt ctgaagagat tgtgttagct ccaaagcttt tcctatcgca     2580

gtgtttcagt tctttatttt cccttgtgga tatgctgtgt gaaccgtcgt gtgagtgtgg     2640

tatgcctgat cacagatgga ttttgttata agcatcaatg tgacacttgc aggacactac     2700

aacgtgggac attgtttgtt tcttccatat ttggaagata aatttatgtg tagacttttt     2760

tgtaagatac ggttaataac taaaatttat tgaaatggtc ttgcaatgac tcgtattcag     2820

atgcttaaag aaagcattgc tgctacaaat atttctattt ttagaaaggg tttttatgga     2880

ccaatgcccc agttgtcagt cagagccgtt ggtgtttttc attgtttaaa atgtcacctg     2940

taaaatgggc attatttatg tttttttttt tgcattcctg ataattgtat gtattgtata     3000

aagaacgtct gtacattggg ttataacact agtatattta aacttacagg cttatttgta     3060

atgtaaacca ccattttaat gtactgtaat taacatggtt ataatacgta caatccttcc     3120

ctcatcccat cacacaactt tttttgtgtg tgataaactg attttggttt gcaataaaac     3180

cttgaaaaat atttacatat aaaaaaaa                                        3208


<210> 35
<211> 2459
<212> DNA
<213> Homo sapiens

<400> 35
aagtggggtt cataacagaa cagggatagc cgtctctggc tcgtgctctc atgtcatctc       60

agagttccag cttatcagag gcatgtagca gggaggctta ttccagccat aactgggctc      120

tacctccagc ctccagaagt aatccccaac ctgcatatcc ttgggcaacc cgaagaatga      180

aagaagaagc tataaaaccc cctttgaaag ctttcatgaa gcagaggagg atgggtctga      240

acgactttat tcagaagatt gccaataact cctatgcatg caaacaccct gaagttcagt      300

ccatcttgaa gatctcccaa cctcaggagc ctgagcttat gaatgccaac ccttctcctc      360

caccaagtcc ttctcagcaa atcaaccttg gcccgtcgtc caatcctcat gctaaaccat      420

ctgactttca cttcttgaaa gtgatcggaa agggcagttt tggaaaggtt cttctagcaa      480

gacacaaggc agaagaagtg ttctatgcag tcaaagtttt acagaagaaa gcaatcctga      540

aaaagaaaga ggagaagcat attatgtcgg agcggaatgt tctgttgaag aatgtgaagc      600

accctttcct ggtgggcctt cacttctctt tccagactgc tgacaaattg tactttgtcc      660

tagactacat taatggtgga gagttgttct accatctcca gagggaacgc tgcttcctgg      720

aaccacgggc tcgtttctat gctgctgaaa tagccagtgc cttgggctac ctgcattcac      780

tgaacatcgt ttatagagac ttaaaaccag agaatatttt gctagattca cagggacaca      840

ttgtccttac tgacttcgga ctctgcaagg agaacattga acacaacagc acaacatcca      900

ccttctgtgg cacgccggag tatctcgcac ctgaggtgct tcataagcag ccttatgaca      960

ggactgtgga ctggtggtgc ctgggagctg tcttgtatga gatgctgtat ggcctgccgc     1020

ctttttatag ccgaaacaca gctgaaatgt acgacaacat tctgaacaag cctctccagc     1080

tgaaaccaaa tattacaaat tccgcaagac acctcctgga gggcctcctg cagaaggaca     1140

ggacaaagcg gctcggggcc aaggatgact tcatggagat taagagtcat gtcttcttct     1200

ccttaattaa ctgggatgat ctcattaata agaagattac tccccctttt aacccaaatg     1260

tgagtgggcc caacgaccta cggcactttg accccgagtt taccgaagag cctgtcccca     1320

actccattgg caagtcccct gacagcgtcc tcgtcacagc cagcgtcaag gaagctgccg     1380

aggctttcct aggcttttcc tatgcgcctc ccacggactc tttcctctga accctgttag     1440

ggcttggttt taaaggattt tatgtgtgtt tccgaatgtt ttagttagcc ttttggtgga     1500

gccgccagct gacaggacat cttacaagag aatttgcaca tctctggaag cttagcaatc     1560

ttattgcaca ctgttcgctg gaagcttttt gaagagcaca ttctcctcag tgagctcatg     1620

aggttttcat ttttattctt ccttccaacg tggtgctatc tctgaaacga gcgttagagt     1680

gccgccttag acggaggcag gagtttcgtt agaaagcgga cgctgttcta aaaaaggtct     1740

cctgcagatc tgtctgggct gtgatgacga atattatgaa atgtgccttt tctgaagaga     1800

ttgtgttagc tccaaagctt ttcctatcgc agtgtttcag ttctttattt tcccttgtgg     1860

atatgctgtg tgaaccgtcg tgtgagtgtg gtatgcctga tcacagatgg attttgttat     1920

aagcatcaat gtgacacttg caggacacta caacgtggga cattgtttgt ttcttccata     1980

tttggaagat aaatttatgt gtagactttt ttgtaagata cggttaataa ctaaaattta     2040

ttgaaatggt cttgcaatga ctcgtattca gatgcttaaa gaaagcattg ctgctacaaa     2100

tatttctatt tttagaaagg gtttttatgg accaatgccc cagttgtcag tcagagccgt     2160

tggtgttttt cattgtttaa aatgtcacct gtaaaatggg cattatttat gttttttttt     2220

ttgcattcct gataattgta tgtattgtat aaagaacgtc tgtacattgg gttataacac     2280

tagtatattt aaacttacag gcttatttgt aatgtaaacc accattttaa tgtactgtaa     2340

ttaacatggt tataatacgt acaatccttc cctcatccca tcacacaact ttttttgtgt     2400

gtgataaact gattttggtt tgcaataaaa ccttgaaaaa tatttacata taaaaaaaa      2459


<210> 36
<211> 2638
<212> DNA
<213> Homo sapiens

<400> 36
acattcctga cctctccctc ccccttttcc ctctttcttt ccttccttcc tcctcttcca       60

agttctggga tttttcagcc ttgcttggtt ttggccaaaa gcacaaaaaa ggcgttttcg      120

gaagcgaccc gaccgtgcac aagggccatt tgtttgtttt gggactcggg gcaggaaatc      180

ttgcccggcc tgagtcacgg cggctccttc aaggaaacgt cagtgctcgc cggtcgctct      240

cgtctgccgc gcgccccgcc gcccgctgcc catgggggag atgcagggcg cgctggccag      300

agcccggctc gagtccctgc tgcggccccg ccacaaaaag agggccgagg cgcagaaaag      360

gagcgagtcc ttcctgctga gcggactggc tttcatgaag cagaggagga tgggtctgaa      420

cgactttatt cagaagattg ccaataactc ctatgcatgc aaacaccctg aagttcagtc      480

catcttgaag atctcccaac ctcaggagcc tgagcttatg aatgccaacc cttctcctcc      540

accaagtcct tctcagcaaa tcaaccttgg cccgtcgtcc aatcctcatg ctaaaccatc      600

tgactttcac ttcttgaaag tgatcggaaa gggcagtttt ggaaaggttc ttctagcaag      660

acacaaggca gaagaagtgt tctatgcagt caaagtttta cagaagaaag caatcctgaa      720

aaagaaagag gagaagcata ttatgtcgga gcggaatgtt ctgttgaaga atgtgaagca      780

ccctttcctg gtgggccttc acttctcttt ccagactgct gacaaattgt actttgtcct      840

agactacatt aatggtggag agttgttcta ccatctccag agggaacgct gcttcctgga      900

accacgggct cgtttctatg ctgctgaaat agccagtgcc ttgggctacc tgcattcact      960

gaacatcgtt tatagagact taaaaccaga gaatattttg ctagattcac agggacacat     1020

tgtccttact gacttcggac tctgcaagga gaacattgaa cacaacagca caacatccac     1080

cttctgtggc acgccggagt atctcgcacc tgaggtgctt cataagcagc cttatgacag     1140

gactgtggac tggtggtgcc tgggagctgt cttgtatgag atgctgtatg gcctgccgcc     1200

tttttatagc cgaaacacag ctgaaatgta cgacaacatt ctgaacaagc ctctccagct     1260

gaaaccaaat attacaaatt ccgcaagaca cctcctggag ggcctcctgc agaaggacag     1320

gacaaagcgg ctcggggcca aggatgactt catggagatt aagagtcatg tcttcttctc     1380

cttaattaac tgggatgatc tcattaataa gaagattact ccccctttta acccaaatgt     1440

gagtgggccc aacgacctac ggcactttga ccccgagttt accgaagagc ctgtccccaa     1500

ctccattggc aagtcccctg acagcgtcct cgtcacagcc agcgtcaagg aagctgccga     1560

ggctttccta ggcttttcct atgcgcctcc cacggactct ttcctctgaa ccctgttagg     1620

gcttggtttt aaaggatttt atgtgtgttt ccgaatgttt tagttagcct tttggtggag     1680

ccgccagctg acaggacatc ttacaagaga atttgcacat ctctggaagc ttagcaatct     1740

tattgcacac tgttcgctgg aagctttttg aagagcacat tctcctcagt gagctcatga     1800

ggttttcatt tttattcttc cttccaacgt ggtgctatct ctgaaacgag cgttagagtg     1860

ccgccttaga cggaggcagg agtttcgtta gaaagcggac gctgttctaa aaaaggtctc     1920

ctgcagatct gtctgggctg tgatgacgaa tattatgaaa tgtgcctttt ctgaagagat     1980

tgtgttagct ccaaagcttt tcctatcgca gtgtttcagt tctttatttt cccttgtgga     2040

tatgctgtgt gaaccgtcgt gtgagtgtgg tatgcctgat cacagatgga ttttgttata     2100

agcatcaatg tgacacttgc aggacactac aacgtgggac attgtttgtt tcttccatat     2160

ttggaagata aatttatgtg tagacttttt tgtaagatac ggttaataac taaaatttat     2220

tgaaatggtc ttgcaatgac tcgtattcag atgcttaaag aaagcattgc tgctacaaat     2280

atttctattt ttagaaaggg tttttatgga ccaatgcccc agttgtcagt cagagccgtt     2340

ggtgtttttc attgtttaaa atgtcacctg taaaatgggc attatttatg tttttttttt     2400

tgcattcctg ataattgtat gtattgtata aagaacgtct gtacattggg ttataacact     2460

agtatattta aacttacagg cttatttgta atgtaaacca ccattttaat gtactgtaat     2520

taacatggtt ataatacgta caatccttcc ctcatcccat cacacaactt tttttgtgtg     2580

tgataaactg attttggttt gcaataaaac cttgaaaaat atttacatat aaaaaaaa       2638


<210> 37
<211> 2282
<212> DNA
<213> Homo sapiens

<400> 37
ttttttataa ggccgagcgc gcggcctggc gcagcatacg ccgagccggt ctttgagcgc       60

taacgtcttt ctgtctcccc gcggtggtga tgacggtgaa aactgaggct gctaagggca      120

ccctcactta ctccaggatg aggggcatgg tggcaattct catcgctttc atgaagcaga      180

ggaggatggg tctgaacgac tttattcaga agattgccaa taactcctat gcatgcaaac      240

accctgaagt tcagtccatc ttgaagatct cccaacctca ggagcctgag cttatgaatg      300

ccaacccttc tcctccacca agtccttctc agcaaatcaa ccttggcccg tcgtccaatc      360

ctcatgctaa accatctgac tttcacttct tgaaagtgat cggaaagggc agttttggaa      420

aggttcttct agcaagacac aaggcagaag aagtgttcta tgcagtcaaa gttttacaga      480

agaaagcaat cctgaaaaag aaagagttgt tctaccatct ccagagggaa cgctgcttcc      540

tggaaccacg ggctcgtttc tatgctgctg aaatagccag tgccttgggc tacctgcatt      600

cactgaacat cgtttataga gacttaaaac cagagaatat tttgctagat tcacagggac      660

acattgtcct tactgacttc ggactctgca aggagaacat tgaacacaac agcacaacat      720

ccaccttctg tggcacgccg gagtatctcg cacctgaggt gcttcataag cagccttatg      780

acaggactgt ggactggtgg tgcctgggag ctgtcttgta tgagatgctg tatggcctgc      840

cgccttttta tagccgaaac acagctgaaa tgtacgacaa cattctgaac aagcctctcc      900

agctgaaacc aaatattaca aattccgcaa gacacctcct ggagggcctc ctgcagaagg      960

acaggacaaa gcggctcggg gccaaggatg acttcatgga gattaagagt catgtcttct     1020

tctccttaat taactgggat gatctcatta ataagaagat tactccccct tttaacccaa     1080

atgtgagtgg gcccaacgac ctacggcact ttgaccccga gtttaccgaa gagcctgtcc     1140

ccaactccat tggcaagtcc cctgacagcg tcctcgtcac agccagcgtc aaggaagctg     1200

ccgaggcttt cctaggcttt tcctatgcgc ctcccacgga ctctttcctc tgaaccctgt     1260

tagggcttgg ttttaaagga ttttatgtgt gtttccgaat gttttagtta gccttttggt     1320

ggagccgcca gctgacagga catcttacaa gagaatttgc acatctctgg aagcttagca     1380

atcttattgc acactgttcg ctggaagctt tttgaagagc acattctcct cagtgagctc     1440

atgaggtttt catttttatt cttccttcca acgtggtgct atctctgaaa cgagcgttag     1500

agtgccgcct tagacggagg caggagtttc gttagaaagc ggacgctgtt ctaaaaaagg     1560

tctcctgcag atctgtctgg gctgtgatga cgaatattat gaaatgtgcc ttttctgaag     1620

agattgtgtt agctccaaag cttttcctat cgcagtgttt cagttcttta ttttcccttg     1680

tggatatgct gtgtgaaccg tcgtgtgagt gtggtatgcc tgatcacaga tggattttgt     1740

tataagcatc aatgtgacac ttgcaggaca ctacaacgtg ggacattgtt tgtttcttcc     1800

atatttggaa gataaattta tgtgtagact tttttgtaag atacggttaa taactaaaat     1860

ttattgaaat ggtcttgcaa tgactcgtat tcagatgctt aaagaaagca ttgctgctac     1920

aaatatttct atttttagaa agggttttta tggaccaatg ccccagttgt cagtcagagc     1980

cgttggtgtt tttcattgtt taaaatgtca cctgtaaaat gggcattatt tatgtttttt     2040

tttttgcatt cctgataatt gtatgtattg tataaagaac gtctgtacat tgggttataa     2100

cactagtata tttaaactta caggcttatt tgtaatgtaa accaccattt taatgtactg     2160

taattaacat ggttataata cgtacaatcc ttccctcatc ccatcacaca actttttttg     2220

tgtgtgataa actgattttg gtttgcaata aaaccttgaa aaatatttac atataaaaaa     2280

aa                                                                    2282


<210> 38
<211> 2414
<212> DNA
<213> Homo sapiens

<400> 38
ttttttataa ggccgagcgc gcggcctggc gcagcatacg ccgagccggt ctttgagcgc       60

taacgtcttt ctgtctcccc gcggtggtga tgacggtgaa aactgaggct gctaagggca      120

ccctcactta ctccaggatg aggggcatgg tggcaattct catcgctttc atgaagcaga      180

ggaggatggg tctgaacgac tttattcaga agattgccaa taactcctat gcatgcaaac      240

accctgaagt tcagtccatc ttgaagatct cccaacctca ggagcctgag cttatgaatg      300

ccaacccttc tcctccacca agtccttctc agcaaatcaa ccttggcccg tcgtccaatc      360

ctcatgctaa accatctgac tttcacttct tgaaagtgat cggaaagggc agttttggaa      420

aggttcttct agcaagacac aaggcagaag aagtgttcta tgcagtcaaa gttttacaga      480

agaaagcaat cctgaaaaag aaagaggaga agcatattat gtcggagcgg aatgttctgt      540

tgaagaatgt gaagcaccct ttcctggtgg gccttcactt ctctttccag actgctgaca      600

aattgtactt tgtcctagac tacattaatg gtggagagtt gttctaccat ctccagaggg      660

aacgctgctt cctggaacca cgggctcgtt tctatgctgc tgaaatagcc agtgccttgg      720

gctacctgca ttcactgaac atcgtttata gagacttaaa accagagaat attttgctag      780

attcacaggg acacattgtc cttactgact tcggactctg caaggagaac attgaacaca      840

acagcacaac atccaccttc tgtggcacgc cggagtatct cgcacctgag gtgcttcata      900

agcagcctta tgacaggact gtggactggt ggtgcctggg agctgtcttg tatgagatgc      960

tgtatggcct gccgcctttt tatagccgaa acacagctga aatgtacgac aacattctga     1020

acaagcctct ccagctgaaa ccaaatatta caaattccgc aagacacctc ctggagggcc     1080

tcctgcagaa ggacaggaca aagcggctcg gggccaagga tgacttcatg gagattaaga     1140

gtcatgtctt cttctcctta attaactggg atgatctcat taataagaag attactcccc     1200

cttttaaccc aaatgtgagt gggcccaacg acctacggca ctttgacccc gagtttaccg     1260

aagagcctgt ccccaactcc attggcaagt cccctgacag cgtcctcgtc acagccagcg     1320

tcaaggaagc tgccgaggct ttcctaggct tttcctatgc gcctcccacg gactctttcc     1380

tctgaaccct gttagggctt ggttttaaag gattttatgt gtgtttccga atgttttagt     1440

tagccttttg gtggagccgc cagctgacag gacatcttac aagagaattt gcacatctct     1500

ggaagcttag caatcttatt gcacactgtt cgctggaagc tttttgaaga gcacattctc     1560

ctcagtgagc tcatgaggtt ttcattttta ttcttccttc caacgtggtg ctatctctga     1620

aacgagcgtt agagtgccgc cttagacgga ggcaggagtt tcgttagaaa gcggacgctg     1680

ttctaaaaaa ggtctcctgc agatctgtct gggctgtgat gacgaatatt atgaaatgtg     1740

ccttttctga agagattgtg ttagctccaa agcttttcct atcgcagtgt ttcagttctt     1800

tattttccct tgtggatatg ctgtgtgaac cgtcgtgtga gtgtggtatg cctgatcaca     1860

gatggatttt gttataagca tcaatgtgac acttgcagga cactacaacg tgggacattg     1920

tttgtttctt ccatatttgg aagataaatt tatgtgtaga cttttttgta agatacggtt     1980

aataactaaa atttattgaa atggtcttgc aatgactcgt attcagatgc ttaaagaaag     2040

cattgctgct acaaatattt ctatttttag aaagggtttt tatggaccaa tgccccagtt     2100

gtcagtcaga gccgttggtg tttttcattg tttaaaatgt cacctgtaaa atgggcatta     2160

tttatgtttt tttttttgca ttcctgataa ttgtatgtat tgtataaaga acgtctgtac     2220

attgggttat aacactagta tatttaaact tacaggctta tttgtaatgt aaaccaccat     2280

tttaatgtac tgtaattaac atggttataa tacgtacaat ccttccctca tcccatcaca     2340

caactttttt tgtgtgtgat aaactgattt tggtttgcaa taaaaccttg aaaaatattt     2400

acatataaaa aaaa                                                       2414


<210> 39
<211> 9104
<212> DNA
<213> Homo sapiens

<400> 39
tctccctcgg cgccgccgcc gccgcccgcg gggctgggac ccgatgcggt tagagccgcg       60

gagcctggaa gagccccgag cgtttctgct ttgggacaac catacatcta attccttaaa      120

gtagttttat atgtaaaact tgcaaagaat cagaacaatg cctccacgac catcatcagg      180

tgaactgtgg ggcatccact tgatgccccc aagaatccta gtagaatgtt tactaccaaa      240

tggaatgata gtgactttag aatgcctccg tgaggctaca ttaataacca taaagcatga      300

actatttaaa gaagcaagaa aataccccct ccatcaactt cttcaagatg aatcttctta      360

cattttcgta agtgttactc aagaagcaga aagggaagaa ttttttgatg aaacaagacg      420

actttgtgac cttcggcttt ttcaaccctt tttaaaagta attgaaccag taggcaaccg      480

tgaagaaaag atcctcaatc gagaaattgg ttttgctatc ggcatgccag tgtgtgaatt      540

tgatatggtt aaagatccag aagtacagga cttccgaaga aatattctga acgtttgtaa      600

agaagctgtg gatcttaggg acctcaattc acctcatagt agagcaatgt atgtctatcc      660

tccaaatgta gaatcttcac cagaattgcc aaagcacata tataataaat tagataaagg      720

gcaaataata gtggtgatct gggtaatagt ttctccaaat aatgacaagc agaagtatac      780

tctgaaaatc aaccatgact gtgtaccaga acaagtaatt gctgaagcaa tcaggaaaaa      840

aactcgaagt atgttgctat cctctgaaca actaaaactc tgtgttttag aatatcaggg      900

caagtatatt ttaaaagtgt gtggatgtga tgaatacttc ctagaaaaat atcctctgag      960

tcagtataag tatataagaa gctgtataat gcttgggagg atgcccaatt tgatgttgat     1020

ggctaaagaa agcctttatt ctcaactgcc aatggactgt tttacaatgc catcttattc     1080

cagacgcatt tccacagcta caccatatat gaatggagaa acatctacaa aatccctttg     1140

ggttataaat agtgcactca gaataaaaat tctttgtgca acctacgtga atgtaaatat     1200

tcgagacatt gataagatct atgttcgaac aggtatctac catggaggag aacccttatg     1260

tgacaatgtg aacactcaaa gagtaccttg ttccaatccc aggtggaatg aatggctgaa     1320

ttatgatata tacattcctg atcttcctcg tgctgctcga ctttgccttt ccatttgctc     1380

tgttaaaggc cgaaagggtg ctaaagagga acactgtcca ttggcatggg gaaatataaa     1440

cttgtttgat tacacagaca ctctagtatc tggaaaaatg gctttgaatc tttggccagt     1500

acctcatgga ttagaagatt tgctgaaccc tattggtgtt actggatcaa atccaaataa     1560

agaaactcca tgcttagagt tggagtttga ctggttcagc agtgtggtaa agttcccaga     1620

tatgtcagtg attgaagagc atgccaattg gtctgtatcc cgagaagcag gatttagcta     1680

ttcccacgca ggactgagta acagactagc tagagacaat gaattaaggg aaaatgacaa     1740

agaacagctc aaagcaattt ctacacgaga tcctctctct gaaatcactg agcaggagaa     1800

agattttcta tggagtcaca gacactattg tgtaactatc cccgaaattc tacccaaatt     1860

gcttctgtct gttaaatgga attctagaga tgaagtagcc cagatgtatt gcttggtaaa     1920

agattggcct ccaatcaaac ctgaacaggc tatggaactt ctggactgta attacccaga     1980

tcctatggtt cgaggttttg ctgttcggtg cttggaaaaa tatttaacag atgacaaact     2040

ttctcagtat ttaattcagc tagtacaggt cctaaaatat gaacaatatt tggataactt     2100

gcttgtgaga tttttactga agaaagcatt gactaatcaa aggattgggc actttttctt     2160

ttggcattta aaatctgaga tgcacaataa aacagttagc cagaggtttg gcctgctttt     2220

ggagtcctat tgtcgtgcat gtgggatgta tttgaagcac ctgaataggc aagtcgaggc     2280

aatggaaaag ctcattaact taactgacat tctcaaacag gagaagaagg atgaaacaca     2340

aaaggtacag atgaagtttt tagttgagca aatgaggcga ccagatttca tggatgctct     2400

acagggcttt ctgtctcctc taaaccctgc tcatcaacta ggaaacctca ggcttgaaga     2460

gtgtcgaatt atgtcctctg caaaaaggcc actgtggttg aattgggaga acccagacat     2520

catgtcagag ttactgtttc agaacaatga gatcatcttt aaaaatgggg atgatttacg     2580

gcaagatatg ctaacacttc aaattattcg tattatggaa aatatctggc aaaatcaagg     2640

tcttgatctt cgaatgttac cttatggttg tctgtcaatc ggtgactgtg tgggacttat     2700

tgaggtggtg cgaaattctc acactattat gcaaattcag tgcaaaggcg gcttgaaagg     2760

tgcactgcag ttcaacagcc acacactaca tcagtggctc aaagacaaga acaaaggaga     2820

aatatatgat gcagccattg acctgtttac acgttcatgt gctggatact gtgtagctac     2880

cttcattttg ggaattggag atcgtcacaa tagtaacatc atggtgaaag acgatggaca     2940

actgtttcat atagattttg gacacttttt ggatcacaag aagaaaaaat ttggttataa     3000

acgagaacgt gtgccatttg ttttgacaca ggatttctta atagtgatta gtaaaggagc     3060

ccaagaatgc acaaagacaa gagaatttga gaggtttcag gagatgtgtt acaaggctta     3120

tctagctatt cgacagcatg ccaatctctt cataaatctt ttctcaatga tgcttggctc     3180

tggaatgcca gaactacaat cttttgatga cattgcatac attcgaaaga ccctagcctt     3240

agataaaact gagcaagagg ctttggagta tttcatgaaa caaatgaatg atgcacatca     3300

tggtggctgg acaacaaaaa tggattggat cttccacaca attaaacagc atgcattgaa     3360

ctgaaaagat aactgagaaa atgaaagctc actctggatt ccacactgca ctgttaataa     3420

ctctcagcag gcaaagaccg attgcatagg aattgcacaa tccatgaaca gcattagaat     3480

ttacagcaag aacagaaata aaatactata taatttaaat aatgtaaacg caaacagggt     3540

ttgatagcac ttaaactagt tcatttcaaa attaagcttt agaataatgc gcaatttcat     3600

gttatgcctt aagtccaaaa aggtaaactt tgaagattgt ttgtatcttt ttttaaaaaa     3660

caaaacaaaa caaaaatccc caaaatatat agaaatgatg gagaaggaaa aagtgatggt     3720

tttttttgtc ttgcaaatgt tctatgtttt gaaatgtgga cacaacaaag gctgttattg     3780

cattaggtgt aagtaaactg gagtttatgt taaattacat tgattggaaa agaatgaaaa     3840

tttcttattt ttccattgct gttcaattta tagtttgaag tgggtttttg actgcttgtt     3900

taatgaagaa aaatgcttgg ggtggaaggg actcttgaga tttcaccaga gactttttct     3960

ttttaataaa tcaaaccttt tgatgatttg aggttttatc tgcagttttg gaagcagtca     4020

caaatgagac ctgttataag gtggtatttt tttttttctt ctggacagta tttaaaggat     4080

cttattctta tttcccaggg aaattctggg ctcccacaaa gtaaaaaaaa aaaaaaatca     4140

tagaaaaaga atgagcagga atagttctta ttccagaatt gtacagtatt caccttaagt     4200

tgattttttt tctccttctg caattgaact gaatacattt ttcatgcatg ttttccagaa     4260

aatagaagta ttaatgttat taaaaagatt atttttttta ttaaaggcta tttatattat     4320

agaaactatc attaatatat attctttatt tacatgatct gtcccatagt catgcattgt     4380

tttgcacccc aaatttttta ttgttcatag cagcatggtc agctttcttc ttgatctata     4440

gatgaggctc aggcactatc ccatttatac caataaccag tgtataacta cttaaggaaa     4500

acataaaaac ttcatcttct ttccttttat ttcttatgtg aatctcccgt cttccattct     4560

cttttataat tgagaatgtc tcaatcatat gaaattagtt accagaatta acacaattta     4620

gactatcttc ctgattcctt aaaccccttt actgaagtat actcatgaat aatactttaa     4680

aatatggggg aatagaaacc atgaactttt taccttttta aactatttat ccatatctcc     4740

aaagtagaac attaaaccat tttaagatat gtctcattcc caagtagtca gagctcactc     4800

tccaacttta ttaaatacta tttgagcaca ggacacattc ttaaacattt tgaaaaacat     4860

taacccaaga tgtagaggct actgctagtc gtcattctag aatctgatat tttactctgt     4920

atttgaaatg aatgattaat gtcctaggaa attagcttta gcagatgtcc aggtgccaca     4980

tcaaaaaagt gcaataatta ttgacagttt tttagattag gcatattatt ggaaaacaac     5040

tttataaaga gtgaacattg tatactctag taaaacagca tcactttaaa aatattcatt     5100

tatgaaatct gttacctata gttgaagtct tgagtagtga acaagggact ctaataccaa     5160

tactcttaat atctggctat tttagatccc ttaaagggca taattattgg aaatttaggt     5220

atttcactaa agcatgtata taatattgcc aacaagaaaa gtaaatttga agattaaggg     5280

aacttacttc tgcaaactgt cttgcgatag ttaagcagaa tttaaactct gttttaagca     5340

ggaaaccaga aagattattt tgcagttgta gaagatttca taacttatta aaacttatta     5400

acattttgtg ttgtttagat ataggcagtt gatacatact aacatcccag ccttttcaat     5460

atcagggtta aattatagga aaactcagta aaatggtaca aatctgaaag tttgatggta     5520

gaaactgaag atttaacaga gaactgtgtt ttacccgagt gccaaaaatg ctgtgagcct     5580

ccttgcacaa aatttatacc acttttgcat ttttatctat cagtccagat agttgtctcc     5640

cctccttctc ccaggacctc tccaccatta aaatgcacaa accacatggc cgatttcacc     5700

atttacattt attttcaaaa gttactacaa ccaaattaat tctattagaa gaaatgtaga     5760

caaattctat aaagactata gattgtgacc taagaaagaa atgaggcaaa gaaccaaaca     5820

ttgaattaaa tgctacatgg gtgactaaga tctgtttcaa gtcagtgata atatagccac     5880

ttctgggtac ttcagtatca gagatcagtt ctcgtggttt agacagttcc tatctatagc     5940

tgactatcct tgtccttgaa tatggtgtaa ctgactattg gctctacagt tttattgggc     6000

cacttaagaa atatttcctt gaataattat tttgagaaaa agtctaaaag taataaaaat     6060

aattttaaac acactgtagt aagaaatgac tgttggaaaa ttatgctttc actttctacc     6120

atattctcag ctatacaaaa ccatttattt tgaagatttt tagactactg ttaatttgaa     6180

atctgttact cttattgtgg aatttgtttt tttaaaaaag atgtttctaa ttggattttt     6240

aaaagaagaa tggaatttgg ttgctatttt acaatagaac ctaagctttt tgtggttctt     6300

agtgtcctat gtaaaactta gtgtcaaagt aatcaacttt gagattttcc cttctattct     6360

gctttatatt aaaagcccat tagaaaatgg gaacctggtg aatatataat gaattgtaaa     6420

atattttaat gtgtaacttt ttcaactgtg aaactgactt gattttttga tgaaaacagc     6480

tgctgataaa gtattttgtg taaagtgtag ttcttattaa tcaggaaaat gatgacttga     6540

ttagactgta tatgccctct tggattttat tttaaatgga ttggtgactt tcacataggt     6600

aaaacacagt ccatctgtat tcttttttcc atcaaaaatc gagtgatttg gaattataaa     6660

aaaattgtga gcagcctatt tgaaaggcat catggaaatt tcacagcaca ataacacgga     6720

tttgtttttt cttaatgatg taaatccgtt taattcatac tttgatcaat agcccatgct     6780

tgccaactct gaagaaattt aatttccagc agtattttaa agctagcctg ttaacttttt     6840

ctgaatattt aaagttcctc ttttttctat gtctgcacaa actgcagacc tgggctggac     6900

ccacatactc aagagtccac cttaagaaat tattttgatg tccaagacat cactaaaata     6960

tttaagttta aagataatat gtggtgttaa tagattgtgg tgcttttact atttaaagac     7020

aactttcata cttcagatgt ttttgagaag aggggaatgt gaggggaggg ggcagaacag     7080

ggaggagttg tttgaatgaa ttacattctt tatatccatc ctgctcattt ggggcatgtc     7140

tttaagagaa ggctgaaagt tgtgagagta tattgtatac cgtaagagaa tcaactcttc     7200

atcatggatg ggattgtgaa ggctgaacta taaaattcag cattgacagc atcctcaatt     7260

aataattctt ggtgacagaa taatacagct gggctgtttt ttaaaatata aacaatacca     7320

tttttaatta ttacattaaa aattgtaaat atatctatgt gccatggcct gggaagcctg     7380

ctttcttttt tcataaaaat tatttttact gtatgaaaag atcatggggt ttagctcaaa     7440

atatctgtgg tcctgataaa attggattgg taactctacc tcagaaggaa aatgggaaaa     7500

aaaaatagat gagtcacaat tcaatacttc aagctcagaa actgtgcaga tcactgaatt     7560

ttagatttat aaagtcagag ttggcatgcc ttgtttttaa tgatatggaa gaccttaaga     7620

aaaaaacttg gctgaagttt aatcgttggt ccagccattt gaaaaaggca atagtttgag     7680

gaggttcccg aattcggcat ttgaaattca ttttgttctc tcttcttcat tattagtgca     7740

tttggtgtgt gtatacttgc acacaattct gtttgtgtac acactgcttg cttagcccta     7800

gtcaagaggc atcttttata aaaggtgtaa agaaatatca aggttctaaa attcggaaga     7860

gtttagaatt tattaggagt ttcccaagtt gggatgttag tctttaaata aacttcatgc     7920

acctattcca cttaaggttt tgcacctcct ttttattagt gcagtgccat ttcttctgct     7980

tgattttagg tatgttaata ttccagcctt gctagttagc ataaagtgac aggtgtgagc     8040

catgaggaaa ttttctgact taatttgtac acaactacat ataagagttt tagtggagga     8100

aaaaaattag tcccttgtgc gtatacagta gttaggtaaa tgatttttct accaacagta     8160

tactccattc ctcatgtagg taagtacaga aaaggttttt aaatgtattt ttttagccag     8220

ttaaagtcta tgaatctatc tgcaacctta tttaatctgt cactataata attttgtggt     8280

tatgctaaga accatgtata cttttaggta ttcttatttt tgtcaatttt tctaggttgg     8340

caaggaggca gaaaaccttc attgtttcat attaaaatat aattagacta aacttaattc     8400

tagtatgaat ttccaaaatc attatctatt tatttcattt ttatttaatt ttgtttttat     8460

ttcattttta aaagtccctt gttcaattta acttatgttc ctaagagagg ttggagaact     8520

tggccttcat ctgatttcaa aaatgttttg agtttcaaat gaagttaatg gtttcagtgt     8580

gattcagtcc tcagacctaa ttgggttgaa taaaatctaa aagaatatac ccttttggag     8640

cataacattt taataccttg gggaatgtgg cactaccaaa agaagactac taacacgtca     8700

gatgttcacc tggaagcttt atcaagaaat tcgaaccacc cttttggccc cattaattgt     8760

agcaagttta tttctctata ttttgtcatt cagtgaattg aagtcctgtg gtatactgca     8820

ttcattagaa gaaaaacgtt tttaatgtcc ttttaatgat ggcccagaaa gcatttgaca     8880

cagcaagatg catgtgttac tatattgaga atatagaata ataacagtat cactaaattt     8940

aagacctctt cccagtcttg ctgttcctag caagaagttt ggcctgtgac tgcacttact     9000

gtttatgctc atcagaaact gtcaatgtct gcttttcttt aactctgcag tctgtaacat     9060

cacgctgttt attaaaaaaa aaaagaaaaa ttaaaaaaaa aaaa                      9104


<210> 40
<211> 97
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 40
tgctgttgac agtgagcgca ggaattataa tgcttatcta tagtgaagcc acagatgtat       60

agataagcat tataattcct atgcctactg cctcgga                                97


<210> 41
<211> 97
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 41
tgctgttgac agtgagcgca gaagtgttct atgcagtcaa tagtgaagcc acagatgtat       60

tgactgcata gaacacttct ttgcctactg cctcgga                                97


<210> 42
<211> 97
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 42
tgctgttgac agtgagcgag gagcggaatg ttctgttgaa tagtgaagcc acagatgtat       60

tcaacagaac attccgctcc gtgcctactg cctcgga                                97


<210> 43
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Gly Arg Pro Arg Thr Ser Ser Phe Ala Glu Gly Lys Lys 
1               5                   10              


<210> 44
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 44
ctgatcaccg gcctcaat                                                     18


<210> 45
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 45
ggaagacatt gagcttctct gg                                                22


<210> 46
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 46
ttcttgtccc accacttgaa                                                   20


<210> 47
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 47
ctgacatgtg acatcctggt g                                                 21


<210> 48
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 48
cctcagagag tagcagctca ca                                                22


<210> 49
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 49
cagagccttt tcattcttgg a                                                 21


<210> 50
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 50
ctgcagatgg agcatgttgt                                                   20


<210> 51
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 51
tcttcacgag gaggcttgat                                                   20


<210> 52
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 52
cgtcttcccc tccatcgt                                                     18


<210> 53
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 53
gaaggtgtgg tgccagattt                                                   20


<210> 54
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 54
cagctcagtg ctgttggtgg                                                   20


<210> 55
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 55
accatccaac cctggagatc                                                   20


<210> 56
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 56
gacaatcaaa gtccttccca aa                                                22


<210> 57
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 57
ccttttgacc tgtgctgttg t                                                 21


<210> 58
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 58
aaagaaaatc cctcccctct t                                                 21


<210> 59
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 59
cactcacctc aagcccattt                                                   20


<210> 60
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 60
gggagggaga ggtcaggaat                                                   20


<210> 61
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 61
tcgcttgtta cctcctcacg                                                   20


<210> 62
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 62
aattttagaa tttggaagag ga                                                22


<210> 63
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 63
acaaccttaa attaaaccca aa                                                22


<210> 64
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 64
gagggagagg ttaggaatgt                                                   20


<210> 65
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 65
ccctcccttc rcttattacc tcctcac                                           27


<210> 66
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 66
ttttgaagta atttttgaga atatt                                             25


<210> 67
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 67
gacaggactg tggactggtg                                                   20


<210> 68
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 68
tttcagctgt gtttcggcta                                                   20


<210> 69
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 69
Lys Lys Arg Asn Arg Thr Leu Thr Lys 
1               5                   


<210> 70
<211> 15
<212> PRT
<213> Homo sapiens

<400> 70
Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Thr Ala 
1               5                   10                  15  


<210> 71
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 71
gtccgttccg cat                                                          13


<210> 72
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 72
acacgtga                                                                 8


