                         SEQUENCE LISTING

<110>  VASCULAR BIOGENICS LTD
 
<120>  MOTILE SPERM DOMAIN CONTAINING PROTEIN 2 AND INFLAMMATION

<130>  3182.062PC01/GLL/LMB

<150>  62/199,609
<151>  2015-07-31

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  518
<212>  PRT
<213>  Homo sapiens

<220>
<223>  motile sperm domain containing 2, protein variant 1

<400>  1

Met Ala Glu Asn His Ala Gln Asn Lys Ala Lys Leu Ile Ser Glu Thr 
1               5                   10                  15      


Arg Arg Arg Phe Glu Ala Glu Tyr Val Thr Asp Lys Ser Asp Lys Tyr 
            20                  25                  30          


Asp Ala Arg Asp Val Glu Arg Leu Gln Gln Asp Asp Asn Trp Val Glu 
        35                  40                  45              


Ser Tyr Leu Ser Trp Arg His Asn Ile Val Asp Glu Thr Leu Lys Met 
    50                  55                  60                  


Leu Asp Glu Ser Phe Gln Trp Arg Lys Glu Ile Ser Val Asn Asp Leu 
65                  70                  75                  80  


Asn Glu Ser Ser Ile Pro Arg Trp Leu Leu Glu Ile Gly Val Ile Tyr 
                85                  90                  95      


Leu His Gly Tyr Asp Lys Glu Gly Asn Lys Leu Phe Trp Ile Arg Val 
            100                 105                 110         


Lys Tyr His Val Lys Asp Gln Lys Thr Ile Leu Asp Lys Lys Lys Leu 
        115                 120                 125             


Ile Ala Phe Trp Leu Glu Arg Tyr Ala Lys Arg Glu Asn Gly Lys Pro 
    130                 135                 140                 


Val Thr Val Met Phe Asp Leu Ser Glu Thr Gly Ile Asn Ser Ile Asp 
145                 150                 155                 160 


Met Asp Phe Val Arg Phe Ile Ile Asn Cys Phe Lys Val Tyr Tyr Pro 
                165                 170                 175     


Lys Tyr Leu Ser Lys Ile Val Ile Phe Asp Met Pro Trp Leu Met Asn 
            180                 185                 190         


Ala Ala Phe Lys Ile Val Lys Thr Trp Leu Gly Pro Glu Ala Val Ser 
        195                 200                 205             


Leu Leu Lys Phe Thr Ser Lys Asn Glu Val Gln Asp Tyr Val Ser Val 
    210                 215                 220                 


Glu Tyr Leu Pro Pro His Met Gly Gly Thr Asp Pro Phe Lys Tyr Ser 
225                 230                 235                 240 


Tyr Pro Pro Leu Val Asp Asp Asp Phe Gln Thr Pro Leu Cys Glu Asn 
                245                 250                 255     


Gly Pro Ile Thr Ser Glu Asp Glu Thr Ser Ser Lys Glu Asp Ile Glu 
            260                 265                 270         


Ser Asp Gly Lys Glu Thr Leu Glu Thr Ile Ser Asn Glu Glu Gln Thr 
        275                 280                 285             


Pro Leu Leu Lys Lys Ile Asn Pro Thr Glu Ser Thr Ser Lys Ala Glu 
    290                 295                 300                 


Glu Asn Glu Lys Val Asp Ser Lys Val Lys Ala Phe Lys Lys Pro Leu 
305                 310                 315                 320 


Ser Val Phe Lys Gly Pro Leu Leu His Ile Ser Pro Ala Glu Glu Leu 
                325                 330                 335     


Tyr Phe Gly Ser Thr Glu Ser Gly Glu Lys Lys Thr Leu Ile Val Leu 
            340                 345                 350         


Thr Asn Val Thr Lys Asn Ile Val Ala Phe Lys Val Arg Thr Thr Ala 
        355                 360                 365             


Pro Glu Lys Tyr Arg Val Lys Pro Ser Asn Ser Ser Cys Asp Pro Gly 
    370                 375                 380                 


Ala Ser Val Asp Ile Val Val Ser Pro His Gly Gly Leu Thr Val Ser 
385                 390                 395                 400 


Ala Gln Asp Arg Phe Leu Ile Met Ala Ala Glu Met Glu Gln Ser Ser 
                405                 410                 415     


Gly Thr Gly Pro Ala Glu Leu Thr Gln Phe Trp Lys Glu Val Pro Arg 
            420                 425                 430         


Asn Lys Val Met Glu His Arg Leu Arg Cys His Thr Val Glu Ser Ser 
        435                 440                 445             


Lys Pro Asn Thr Leu Thr Leu Lys Asp Asn Ala Phe Asn Met Ser Asp 
    450                 455                 460                 


Lys Thr Ser Glu Asp Ile Cys Leu Gln Leu Ser Arg Leu Leu Glu Ser 
465                 470                 475                 480 


Asn Arg Lys Leu Glu Asp Gln Val Gln Arg Cys Ile Trp Phe Gln Gln 
                485                 490                 495     


Leu Leu Leu Ser Leu Thr Met Leu Leu Leu Ala Phe Val Thr Ser Phe 
            500                 505                 510         


Phe Tyr Leu Leu Tyr Ser 
        515             


<210>  2
<211>  455
<212>  PRT
<213>  Homo sapiens

<220>
<223>  motile sperm domain containing 2, protein variant 2

<400>  2

Met Leu Asp Glu Ser Phe Gln Trp Arg Lys Glu Ile Ser Val Asn Asp 
1               5                   10                  15      


Leu Asn Glu Ser Ser Ile Pro Arg Trp Leu Leu Glu Ile Gly Val Ile 
            20                  25                  30          


Tyr Leu His Gly Tyr Asp Lys Glu Gly Asn Lys Leu Phe Trp Ile Arg 
        35                  40                  45              


Val Lys Tyr His Val Lys Asp Gln Lys Thr Ile Leu Asp Lys Lys Lys 
    50                  55                  60                  


Leu Ile Ala Phe Trp Leu Glu Arg Tyr Ala Lys Arg Glu Asn Gly Lys 
65                  70                  75                  80  


Pro Val Thr Val Met Phe Asp Leu Ser Glu Thr Gly Ile Asn Ser Ile 
                85                  90                  95      


Asp Met Asp Phe Val Arg Phe Ile Ile Asn Cys Phe Lys Val Tyr Tyr 
            100                 105                 110         


Pro Lys Tyr Leu Ser Lys Ile Val Ile Phe Asp Met Pro Trp Leu Met 
        115                 120                 125             


Asn Ala Ala Phe Lys Ile Val Lys Thr Trp Leu Gly Pro Glu Ala Val 
    130                 135                 140                 


Ser Leu Leu Lys Phe Thr Ser Lys Asn Glu Val Gln Asp Tyr Val Ser 
145                 150                 155                 160 


Val Glu Tyr Leu Pro Pro His Met Gly Gly Thr Asp Pro Phe Lys Tyr 
                165                 170                 175     


Ser Tyr Pro Pro Leu Val Asp Asp Asp Phe Gln Thr Pro Leu Cys Glu 
            180                 185                 190         


Asn Gly Pro Ile Thr Ser Glu Asp Glu Thr Ser Ser Lys Glu Asp Ile 
        195                 200                 205             


Glu Ser Asp Gly Lys Glu Thr Leu Glu Thr Ile Ser Asn Glu Glu Gln 
    210                 215                 220                 


Thr Pro Leu Leu Lys Lys Ile Asn Pro Thr Glu Ser Thr Ser Lys Ala 
225                 230                 235                 240 


Glu Glu Asn Glu Lys Val Asp Ser Lys Val Lys Ala Phe Lys Lys Pro 
                245                 250                 255     


Leu Ser Val Phe Lys Gly Pro Leu Leu His Ile Ser Pro Ala Glu Glu 
            260                 265                 270         


Leu Tyr Phe Gly Ser Thr Glu Ser Gly Glu Lys Lys Thr Leu Ile Val 
        275                 280                 285             


Leu Thr Asn Val Thr Lys Asn Ile Val Ala Phe Lys Val Arg Thr Thr 
    290                 295                 300                 


Ala Pro Glu Lys Tyr Arg Val Lys Pro Ser Asn Ser Ser Cys Asp Pro 
305                 310                 315                 320 


Gly Ala Ser Val Asp Ile Val Val Ser Pro His Gly Gly Leu Thr Val 
                325                 330                 335     


Ser Ala Gln Asp Arg Phe Leu Ile Met Ala Ala Glu Met Glu Gln Ser 
            340                 345                 350         


Ser Gly Thr Gly Pro Ala Glu Leu Thr Gln Phe Trp Lys Glu Val Pro 
        355                 360                 365             


Arg Asn Lys Val Met Glu His Arg Leu Arg Cys His Thr Val Glu Ser 
    370                 375                 380                 


Ser Lys Pro Asn Thr Leu Thr Leu Lys Asp Asn Ala Phe Asn Met Ser 
385                 390                 395                 400 


Asp Lys Thr Ser Glu Asp Ile Cys Leu Gln Leu Ser Arg Leu Leu Glu 
                405                 410                 415     


Ser Asn Arg Lys Leu Glu Asp Gln Val Gln Arg Cys Ile Trp Phe Gln 
            420                 425                 430         


Gln Leu Leu Leu Ser Leu Thr Met Leu Leu Leu Ala Phe Val Thr Ser 
        435                 440                 445             


Phe Phe Tyr Leu Leu Tyr Ser 
    450                 455 


<210>  3
<211>  486
<212>  PRT
<213>  Homo sapiens

<220>
<223>  motile sperm domain containing 2, protein variant X1

<400>  3

Met Ala Glu Asn His Ala Gln Asn Lys Ala Lys Leu Ile Ser Glu Thr 
1               5                   10                  15      


Arg Arg Arg Phe Glu Ala Glu Tyr Val Thr Asp Lys Ser Asp Lys Tyr 
            20                  25                  30          


Asp Ala Arg Asp Val Glu Arg Leu Gln Gln Asp Asp Asn Trp Val Glu 
        35                  40                  45              


Ser Tyr Leu Ser Trp Arg His Asn Ile Val Asp Glu Thr Leu Lys Met 
    50                  55                  60                  


Leu Asp Glu Ser Phe Gln Trp Arg Lys Glu Ile Ser Val Asn Asp Leu 
65                  70                  75                  80  


Asn Glu Ser Ser Ile Pro Arg Trp Leu Leu Glu Ile Gly Val Ile Tyr 
                85                  90                  95      


Leu His Gly Tyr Asp Lys Glu Gly Asn Lys Leu Phe Trp Ile Arg Val 
            100                 105                 110         


Lys Tyr His Val Lys Asp Gln Lys Thr Ile Leu Asp Lys Lys Lys Leu 
        115                 120                 125             


Ile Ala Phe Trp Leu Glu Arg Tyr Ala Lys Arg Glu Asn Gly Lys Pro 
    130                 135                 140                 


Val Thr Val Met Phe Asp Leu Ser Glu Thr Gly Ile Asn Ser Ile Asp 
145                 150                 155                 160 


Met Asp Phe Val Arg Phe Ile Ile Asn Cys Phe Lys Val Tyr Tyr Pro 
                165                 170                 175     


Lys Tyr Leu Ser Lys Ile Val Ile Phe Asp Met Pro Trp Leu Met Asn 
            180                 185                 190         


Ala Ala Phe Lys Ile Val Lys Thr Trp Leu Gly Pro Glu Ala Val Ser 
        195                 200                 205             


Leu Leu Lys Phe Thr Ser Lys Asn Glu Val Gln Asp Tyr Val Ser Val 
    210                 215                 220                 


Glu Tyr Leu Pro Pro His Met Gly Gly Thr Asp Pro Phe Lys Tyr Ser 
225                 230                 235                 240 


Tyr Pro Pro Leu Val Asp Asp Asp Phe Gln Thr Pro Leu Cys Glu Asn 
                245                 250                 255     


Gly Pro Ile Thr Ser Glu Asp Glu Thr Ser Ser Lys Glu Asp Ile Glu 
            260                 265                 270         


Ser Asp Gly Lys Glu Thr Leu Glu Thr Ile Ser Asn Glu Glu Gln Thr 
        275                 280                 285             


Pro Leu Leu Lys Lys Ile Asn Pro Thr Glu Ser Thr Ser Lys Ala Glu 
    290                 295                 300                 


Glu Asn Glu Lys Val Asp Ser Lys Val Lys Ala Phe Lys Lys Pro Leu 
305                 310                 315                 320 


Ser Val Phe Lys Gly Pro Leu Leu His Ile Ser Pro Ala Glu Glu Leu 
                325                 330                 335     


Tyr Phe Gly Ser Thr Glu Ser Gly Glu Lys Lys Thr Leu Ile Val Leu 
            340                 345                 350         


Thr Asn Val Thr Lys Asn Ile Val Ala Phe Lys Val Arg Thr Thr Ala 
        355                 360                 365             


Pro Glu Lys Tyr Arg Val Lys Pro Ser Asn Ser Ser Cys Asp Pro Gly 
    370                 375                 380                 


Ala Ser Val Asp Ile Val Val Ser Pro His Gly Gly Leu Thr Val Ser 
385                 390                 395                 400 


Ala Gln Asp Arg Phe Leu Ile Met Ala Ala Glu Met Glu Gln Ser Ser 
                405                 410                 415     


Gly Thr Gly Pro Ala Glu Leu Thr Gln Phe Trp Lys Glu Val Pro Arg 
            420                 425                 430         


Asn Lys Val Met Glu His Arg Leu Arg Cys His Thr Val Glu Ser Ser 
        435                 440                 445             


Lys Pro Asn Thr Leu Thr Leu Lys Asp Asn Ala Phe Asn Met Ser Asp 
    450                 455                 460                 


Lys Thr Ser Glu Asp Ile Cys Leu Gln Phe Ala Thr Ser Ser Cys Glu 
465                 470                 475                 480 


Met Asp Cys Ser Pro Pro 
                485     


<210>  4
<211>  475
<212>  PRT
<213>  Homo sapiens

<220>
<223>  motile sperm domain containing 2, protein variant X2

<400>  4

Met Ala Glu Asn His Ala Gln Asn Lys Ala Lys Leu Ile Ser Glu Thr 
1               5                   10                  15      


Arg Arg Arg Phe Glu Ala Glu Tyr Val Thr Asp Lys Ser Asp Lys Tyr 
            20                  25                  30          


Asp Ala Arg Asp Val Glu Arg Leu Gln Gln Asp Asp Asn Trp Val Glu 
        35                  40                  45              


Ser Tyr Leu Ser Trp Arg His Asn Ile Val Asp Glu Thr Leu Lys Met 
    50                  55                  60                  


Leu Asp Glu Ser Phe Gln Trp Arg Lys Glu Ile Ser Val Asn Asp Leu 
65                  70                  75                  80  


Asn Glu Ser Ser Ile Pro Arg Trp Leu Leu Glu Ile Gly Val Ile Tyr 
                85                  90                  95      


Leu His Gly Tyr Asp Lys Glu Gly Asn Lys Leu Phe Trp Ile Arg Val 
            100                 105                 110         


Lys Tyr His Val Lys Asp Gln Lys Thr Ile Leu Asp Lys Lys Lys Leu 
        115                 120                 125             


Ile Ala Phe Trp Leu Glu Arg Tyr Ala Lys Arg Glu Asn Gly Lys Pro 
    130                 135                 140                 


Val Thr Val Met Phe Asp Leu Ser Glu Thr Gly Ile Asn Ser Ile Asp 
145                 150                 155                 160 


Met Asp Phe Val Arg Phe Ile Ile Asn Cys Phe Lys Val Tyr Tyr Pro 
                165                 170                 175     


Lys Tyr Leu Ser Lys Ile Val Ile Phe Asp Met Pro Trp Leu Met Asn 
            180                 185                 190         


Ala Ala Phe Lys Ile Val Lys Thr Trp Leu Gly Pro Glu Ala Val Ser 
        195                 200                 205             


Leu Leu Lys Phe Thr Ser Lys Asn Glu Val Gln Asp Tyr Val Ser Val 
    210                 215                 220                 


Glu Tyr Leu Pro Pro His Met Gly Gly Thr Asp Pro Phe Lys Tyr Ser 
225                 230                 235                 240 


Tyr Pro Pro Leu Val Asp Asp Asp Phe Gln Thr Pro Leu Cys Glu Asn 
                245                 250                 255     


Gly Pro Ile Thr Ser Glu Asp Glu Thr Ser Ser Lys Glu Asp Ile Glu 
            260                 265                 270         


Ser Asp Gly Lys Glu Thr Leu Glu Thr Ile Ser Asn Glu Glu Gln Thr 
        275                 280                 285             


Pro Leu Leu Lys Lys Ile Asn Pro Thr Glu Ser Thr Ser Lys Ala Glu 
    290                 295                 300                 


Glu Asn Glu Lys Val Asp Ser Lys Val Lys Ala Phe Lys Lys Pro Leu 
305                 310                 315                 320 


Ser Val Phe Lys Gly Pro Leu Leu His Ile Ser Pro Ala Glu Glu Leu 
                325                 330                 335     


Tyr Phe Gly Ser Thr Glu Ser Gly Glu Lys Lys Thr Leu Ile Val Leu 
            340                 345                 350         


Thr Asn Val Thr Lys Asn Ile Val Ala Phe Lys Val Arg Thr Thr Ala 
        355                 360                 365             


Pro Glu Lys Tyr Arg Val Lys Pro Ser Asn Ser Ser Cys Asp Pro Gly 
    370                 375                 380                 


Ala Ser Val Asp Ile Val Val Ser Pro His Gly Gly Leu Thr Val Ser 
385                 390                 395                 400 


Ala Gln Asp Arg Phe Leu Ile Met Ala Ala Glu Met Glu Gln Ser Ser 
                405                 410                 415     


Gly Thr Gly Pro Ala Glu Leu Thr Gln Phe Trp Lys Glu Val Pro Arg 
            420                 425                 430         


Asn Lys Val Met Glu His Arg Leu Arg Cys His Thr Val Glu Ser Ser 
        435                 440                 445             


Lys Pro Asn Thr Leu Thr Leu Lys Asp Asn Ala Phe Asn Met Ser Asp 
    450                 455                 460                 


Lys Thr Ser Glu Asp Ile Cys Leu Gln Tyr Ser 
465                 470                 475 


<210>  5
<211>  3219
<212>  DNA
<213>  Homo sapiens

<220>
<223>  motile sperm domain containing 2, transcript variant 1, mRNA, coding region 125-1678

<400>  5
accgcctccc cctcccaccc ttctctgtct acctctgggc gggactgccg ggtgatgaga       60

tactcggtcg gcgacggtag aacgggcgac ggcgacaacc gcaatcacat ccacgacggt      120

gatcatggca gagaatcacg cccagaataa agccaagctc atctctgaga cccggaggag      180

gttcgaagct gagtatgtga cagataagtc agataaatat gatgcacgtg atgttgaaag      240

gctacaacaa gatgataact gggttgaaag ttacttatct tggagacata atattgtaga      300

tgaaacactg aagatgctcg atgagagttt tcagtggagg aaagaaattt ctgtcaatga      360

ccttaatgaa tcctccattc ccagatggtt attggaaatt ggtgttattt atctccatgg      420

ttatgacaaa gaaggtaaca aattgttctg gatcagggtg aagtatcatg taaaagacca      480

gaaaaccata ttggacaaaa agaagctcat agcattctgg ttggaacgtt atgctaagag      540

ggaaaatggg aaacctgtaa cagtgatgtt tgacctgtca gaaactggaa taaatagcat      600

tgacatggac tttgtacgct ttatcatcaa ctgctttaag gtttattacc ctaaatacct      660

ctcaaaaata gtgatctttg atatgccttg gttaatgaat gctgctttca aaattgtgaa      720

aacctggctt ggtccagaag cagtgagctt gttgaagttt acaagcaaaa atgaagtcca      780

ggactatgtc agtgtagaat acctgcctcc ccacatgggt ggaactgatc ctttcaagta      840

tagctatcca ccactagtag atgatgactt ccagacccca ctgtgtgaga atgggcctat      900

taccagtgag gatgaaactt caagtaaaga agacatagaa agtgatggca aagaaacatt      960

ggaaacaatt tctaatgaag aacaaacacc tcttcttaaa aagattaacc caaccgaatc     1020

tacttccaaa gcagaagaaa atgaaaaagt tgattcaaaa gtgaaagctt tcaagaaacc     1080

attgagtgta tttaaaggcc ccttactaca catcagccca gcagaagaac tgtactttgg     1140

aagtacagaa tccggagaga agaaaacctt aatagtgttg acaaatgtaa ctaaaaatat     1200

agtggcattt aaggtgagaa caacagctcc agaaaaatac agagtcaagc caagcaatag     1260

cagctgtgac ccgggtgcat cagtggatat agttgtgtct ccccatgggg gtttaacagt     1320

ctctgcccaa gaccgttttc tgataatggc tgcagaaatg gaacagtcat ctggcacagg     1380

cccagcagaa ttaactcagt tttggaaaga agttcccaga aacaaagtga tggaacatag     1440

gttaagatgc catactgttg aaagcagtaa accaaacact cttacgttaa aagacaatgc     1500

tttcaatatg tcagataaaa ccagtgaaga tatatgtcta caactcagtc gtttactaga     1560

aagcaatagg aagcttgaag accaagttca gcgttgtatc tggttccagc agctgctgct     1620

ttccttaaca atgctcttgc ttgcttttgt cacctctttc ttctatttat tgtacagtta     1680

aagaagtggt gccgggtagg aaccacggtt ccttcgtcca ttagttggaa aaagtaacag     1740

acctaaaact ctaccaagct actaaaaaca ttgcacatct gtgcttccta aaaggaaata     1800

tgcagcacgt ggaggggaac acatacatgt cttgaaaata aactgctaga ataaagaaat     1860

gctggagaaa ttgattataa gagactatag ctatttagta aagtaagtaa aggcatatcc     1920

attgtgtaaa ttaatagttt aaatataatt tattttttcc ttttgatctg aatactttta     1980

aagcttaagt tttatcgtgt aaatacatta gctaaactga aaagtataag taacatgctt     2040

tgttgcagcc aaaaaatgta atctgctttt ttatgacaga attattatag ctgagctgac     2100

ttactagctt ttctatacta tgtatataga agaacatgta tattgagaaa gaaaacatac     2160

ttatatagag gaatttatgt aaccatgact ttgtaatttt gagaattcct cccagtgatg     2220

gtcagtattc ttttggaatg taaaccgatt taatgccaaa ccaccttaac ctttgtttct     2280

cagtgttcct taacagcctg ccttttatta atctcaggct tttttatgaa cactctcatt     2340

tcagtagaat ttggaaaact aagcgtggtt ggaatttctt tgaattctgt tagtaatgcc     2400

caaaagaaaa gtctcaagca gtccccctat ccagtcattt ttatggagtt tcatgttgtc     2460

cactatagct ggacactgaa ccttttgcct aatttattat aaaggcctga ccctctattg     2520

tcccatcttc acccccattc cagagcagag gagtctctgt ggaccatgaa ttgcactgtc     2580

tccctcctca tttctaaatg aaaggtatta gatataaatt tttttgaaag gttagttgtt     2640

tgagatgcta agcaggataa taaatttaga ttttaaaatg ttccctgtaa aagtcagccc     2700

atgacaagga aatttacaaa atactagagt atctagaagg gtgaaaacaa aaaaaaataa     2760

aaagaaacac agacgcccag gtgtcagctc tccgtttaaa gaatgaaaaa tgtaactcat     2820

gatgatctgt gaaaccttca aactaggacc aattgactta cttgatattc tgcctttgat     2880

atggtagtac ccacccggta ttcctaaaat cctaaaaaga tacaccttgc agtagcagag     2940

gcaatgacat gagtttgttt tctcattaat atgaccagtt tgggtctatg ttggttcaca     3000

tgtacatcta ctttatatga aagaaaaaac agttgtctgc ctgtaaaatg ttgagtttcg     3060

attgagccat gtttggagat tttattacta ttctgaaggg tagtgttgtt ggttttcatc     3120

ttcaagaagt tgattccaaa actgagttat gaagaatgat ataacagttc cttcaaaatt     3180

ggcctaggaa ataaaacctt aaaaggacaa aaaaaaaaa                            3219


<210>  6
<211>  3183
<212>  DNA
<213>  Homo sapiens

<220>
<223>  motile sperm domain containing 2, transcript variant 2, mRNA, coding region 278-1642

<400>  6
agtcacaata ataggtactt aaaaacatgt catatgatag gaaactagaa taacacacct       60

ctaaataatc catggattac caacttctca gcaatggtgt aaattcttct gctaaataac      120

ccgtgggtta aagaggacat cacattggaa attccagagt acttaaaata agtcagataa      180

atatgatgca cgtgatgttg aaaggctaca acaagatgat aactgggttg aaagttactt      240

atcttggaga cataatattg tagatgaaac actgaagatg ctcgatgaga gttttcagtg      300

gaggaaagaa atttctgtca atgaccttaa tgaatcctcc attcccagat ggttattgga      360

aattggtgtt atttatctcc atggttatga caaagaaggt aacaaattgt tctggatcag      420

ggtgaagtat catgtaaaag accagaaaac catattggac aaaaagaagc tcatagcatt      480

ctggttggaa cgttatgcta agagggaaaa tgggaaacct gtaacagtga tgtttgacct      540

gtcagaaact ggaataaata gcattgacat ggactttgta cgctttatca tcaactgctt      600

taaggtttat taccctaaat acctctcaaa aatagtgatc tttgatatgc cttggttaat      660

gaatgctgct ttcaaaattg tgaaaacctg gcttggtcca gaagcagtga gcttgttgaa      720

gtttacaagc aaaaatgaag tccaggacta tgtcagtgta gaatacctgc ctccccacat      780

gggtggaact gatcctttca agtatagcta tccaccacta gtagatgatg acttccagac      840

cccactgtgt gagaatgggc ctattaccag tgaggatgaa acttcaagta aagaagacat      900

agaaagtgat ggcaaagaaa cattggaaac aatttctaat gaagaacaaa cacctcttct      960

taaaaagatt aacccaaccg aatctacttc caaagcagaa gaaaatgaaa aagttgattc     1020

aaaagtgaaa gctttcaaga aaccattgag tgtatttaaa ggccccttac tacacatcag     1080

cccagcagaa gaactgtact ttggaagtac agaatccgga gagaagaaaa ccttaatagt     1140

gttgacaaat gtaactaaaa atatagtggc atttaaggtg agaacaacag ctccagaaaa     1200

atacagagtc aagccaagca atagcagctg tgacccgggt gcatcagtgg atatagttgt     1260

gtctccccat gggggtttaa cagtctctgc ccaagaccgt tttctgataa tggctgcaga     1320

aatggaacag tcatctggca caggcccagc agaattaact cagttttgga aagaagttcc     1380

cagaaacaaa gtgatggaac ataggttaag atgccatact gttgaaagca gtaaaccaaa     1440

cactcttacg ttaaaagaca atgctttcaa tatgtcagat aaaaccagtg aagatatatg     1500

tctacaactc agtcgtttac tagaaagcaa taggaagctt gaagaccaag ttcagcgttg     1560

tatctggttc cagcagctgc tgctttcctt aacaatgctc ttgcttgctt ttgtcacctc     1620

tttcttctat ttattgtaca gttaaagaag tggtgccggg taggaaccac ggttccttcg     1680

tccattagtt ggaaaaagta acagacctaa aactctacca agctactaaa aacattgcac     1740

atctgtgctt cctaaaagga aatatgcagc acgtggaggg gaacacatac atgtcttgaa     1800

aataaactgc tagaataaag aaatgctgga gaaattgatt ataagagact atagctattt     1860

agtaaagtaa gtaaaggcat atccattgtg taaattaata gtttaaatat aatttatttt     1920

ttccttttga tctgaatact tttaaagctt aagttttatc gtgtaaatac attagctaaa     1980

ctgaaaagta taagtaacat gctttgttgc agccaaaaaa tgtaatctgc ttttttatga     2040

cagaattatt atagctgagc tgacttacta gcttttctat actatgtata tagaagaaca     2100

tgtatattga gaaagaaaac atacttatat agaggaattt atgtaaccat gactttgtaa     2160

ttttgagaat tcctcccagt gatggtcagt attcttttgg aatgtaaacc gatttaatgc     2220

caaaccacct taacctttgt ttctcagtgt tccttaacag cctgcctttt attaatctca     2280

ggctttttta tgaacactct catttcagta gaatttggaa aactaagcgt ggttggaatt     2340

tctttgaatt ctgttagtaa tgcccaaaag aaaagtctca agcagtcccc ctatccagtc     2400

atttttatgg agtttcatgt tgtccactat agctggacac tgaacctttt gcctaattta     2460

ttataaaggc ctgaccctct attgtcccat cttcaccccc attccagagc agaggagtct     2520

ctgtggacca tgaattgcac tgtctccctc ctcatttcta aatgaaaggt attagatata     2580

aatttttttg aaaggttagt tgtttgagat gctaagcagg ataataaatt tagattttaa     2640

aatgttccct gtaaaagtca gcccatgaca aggaaattta caaaatacta gagtatctag     2700

aagggtgaaa acaaaaaaaa ataaaaagaa acacagacgc ccaggtgtca gctctccgtt     2760

taaagaatga aaaatgtaac tcatgatgat ctgtgaaacc ttcaaactag gaccaattga     2820

cttacttgat attctgcctt tgatatggta gtacccaccc ggtattccta aaatcctaaa     2880

aagatacacc ttgcagtagc agaggcaatg acatgagttt gttttctcat taatatgacc     2940

agtttgggtc tatgttggtt cacatgtaca tctactttat atgaaagaaa aaacagttgt     3000

ctgcctgtaa aatgttgagt ttcgattgag ccatgtttgg agattttatt actattctga     3060

agggtagtgt tgttggtttt catcttcaag aagttgattc caaaactgag ttatgaagaa     3120

tgatataaca gttccttcaa aattggccta ggaaataaaa ccttaaaagg acaaaaaaaa     3180

aaa                                                                   3183


<210>  7
<211>  2330
<212>  DNA
<213>  Homo sapiens

<220>
<223>  motile sperm domain containing 2, transcript variant X1, mRNA, coding region 125-1582

<400>  7
accgcctccc cctcccaccc ttctctgtct acctctgggc gggactgccg ggtgatgaga       60

tactcggtcg gcgacggtag aacgggcgac ggcgacaacc gcaatcacat ccacgacggt      120

gatcatggca gagaatcacg cccagaataa agccaagctc atctctgaga cccggaggag      180

gttcgaagct gagtatgtga cagataagtc agataaatat gatgcacgtg atgttgaaag      240

gctacaacaa gatgataact gggttgaaag ttacttatct tggagacata atattgtaga      300

tgaaacactg aagatgctcg atgagagttt tcagtggagg aaagaaattt ctgtcaatga      360

ccttaatgaa tcctccattc ccagatggtt attggaaatt ggtgttattt atctccatgg      420

ttatgacaaa gaaggtaaca aattgttctg gatcagggtg aagtatcatg taaaagacca      480

gaaaaccata ttggacaaaa agaagctcat agcattctgg ttggaacgtt atgctaagag      540

ggaaaatggg aaacctgtaa cagtgatgtt tgacctgtca gaaactggaa taaatagcat      600

tgacatggac tttgtacgct ttatcatcaa ctgctttaag gtttattacc ctaaatacct      660

ctcaaaaata gtgatctttg atatgccttg gttaatgaat gctgctttca aaattgtgaa      720

aacctggctt ggtccagaag cagtgagctt gttgaagttt acaagcaaaa atgaagtcca      780

ggactatgtc agtgtagaat acctgcctcc ccacatgggt ggaactgatc ctttcaagta      840

tagctatcca ccactagtag atgatgactt ccagacccca ctgtgtgaga atgggcctat      900

taccagtgag gatgaaactt caagtaaaga agacatagaa agtgatggca aagaaacatt      960

ggaaacaatt tctaatgaag aacaaacacc tcttcttaaa aagattaacc caaccgaatc     1020

tacttccaaa gcagaagaaa atgaaaaagt tgattcaaaa gtgaaagctt tcaagaaacc     1080

attgagtgta tttaaaggcc ccttactaca catcagccca gcagaagaac tgtactttgg     1140

aagtacagaa tccggagaga agaaaacctt aatagtgttg acaaatgtaa ctaaaaatat     1200

agtggcattt aaggtgagaa caacagctcc agaaaaatac agagtcaagc caagcaatag     1260

cagctgtgac ccgggtgcat cagtggatat agttgtgtct ccccatgggg gtttaacagt     1320

ctctgcccaa gaccgttttc tgataatggc tgcagaaatg gaacagtcat ctggcacagg     1380

cccagcagaa ttaactcagt tttggaaaga agttcccaga aacaaagtga tggaacatag     1440

gttaagatgc catactgttg aaagcagtaa accaaacact cttacgttaa aagacaatgc     1500

tttcaatatg tcagataaaa ccagtgaaga tatatgtcta caatttgcca cctccagctg     1560

tgaaatggac tgcagtccac cctaagtact gtgcacagta tctccctgtg tgtgtgcaca     1620

gtggcttccc cttacatggt agatttttgg ccttaatata atctaatccc aaagtagttg     1680

tgtatgtttt ctgttccttg gcaaataaat gaagaaataa ttagccaaga ttgaaaatgt     1740

attgtcctaa cggtgtccct ttaatgtttc atatgaaaaa ttatgttgac ccactaaaat     1800

atccttgctc aatgtctggt cagttgaatt taataacata tcttgttaat gtttgtgtgt     1860

ctattaaatg tgactaagca ggattactga aaattcacta taaaatcaaa ggcatctaaa     1920

cgtttgtact tgtcttgatt aatcatatat ttacacttga tttttttctg tcttcatttg     1980

tttttattta atcataattg catgattttt ttggtactct aatcagtaat tttattttta     2040

atcatgtcat tacctattca tgaccaaatt accaaggaac caacatttag atttagatat     2100

ttgttttcac ttaggaatgg aaattaatag attttccatg aaagcattag tgaaatatca     2160

ttaccttgat ctgcaagtag cctaaaaatg cgattgctgg taaacctggc ctcaaatttc     2220

atactaccat aactgttttt atatattgcc actaattttg actggattta atagcacttt     2280

attgtacaac tacaaaaaaa aatatattcc tagaattgtt gccagtgtaa                2330


<210>  8
<211>  3909
<212>  DNA
<213>  Homo sapiens

<220>
<223>  motile sperm domain containing 2, transcript variant X2, mRNA, coding region 125-1549

<400>  8
accgcctccc cctcccaccc ttctctgtct acctctgggc gggactgccg ggtgatgaga       60

tactcggtcg gcgacggtag aacgggcgac ggcgacaacc gcaatcacat ccacgacggt      120

gatcatggca gagaatcacg cccagaataa agccaagctc atctctgaga cccggaggag      180

gttcgaagct gagtatgtga cagataagtc agataaatat gatgcacgtg atgttgaaag      240

gctacaacaa gatgataact gggttgaaag ttacttatct tggagacata atattgtaga      300

tgaaacactg aagatgctcg atgagagttt tcagtggagg aaagaaattt ctgtcaatga      360

ccttaatgaa tcctccattc ccagatggtt attggaaatt ggtgttattt atctccatgg      420

ttatgacaaa gaaggtaaca aattgttctg gatcagggtg aagtatcatg taaaagacca      480

gaaaaccata ttggacaaaa agaagctcat agcattctgg ttggaacgtt atgctaagag      540

ggaaaatggg aaacctgtaa cagtgatgtt tgacctgtca gaaactggaa taaatagcat      600

tgacatggac tttgtacgct ttatcatcaa ctgctttaag gtttattacc ctaaatacct      660

ctcaaaaata gtgatctttg atatgccttg gttaatgaat gctgctttca aaattgtgaa      720

aacctggctt ggtccagaag cagtgagctt gttgaagttt acaagcaaaa atgaagtcca      780

ggactatgtc agtgtagaat acctgcctcc ccacatgggt ggaactgatc ctttcaagta      840

tagctatcca ccactagtag atgatgactt ccagacccca ctgtgtgaga atgggcctat      900

taccagtgag gatgaaactt caagtaaaga agacatagaa agtgatggca aagaaacatt      960

ggaaacaatt tctaatgaag aacaaacacc tcttcttaaa aagattaacc caaccgaatc     1020

tacttccaaa gcagaagaaa atgaaaaagt tgattcaaaa gtgaaagctt tcaagaaacc     1080

attgagtgta tttaaaggcc ccttactaca catcagccca gcagaagaac tgtactttgg     1140

aagtacagaa tccggagaga agaaaacctt aatagtgttg acaaatgtaa ctaaaaatat     1200

agtggcattt aaggtgagaa caacagctcc agaaaaatac agagtcaagc caagcaatag     1260

cagctgtgac ccgggtgcat cagtggatat agttgtgtct ccccatgggg gtttaacagt     1320

ctctgcccaa gaccgttttc tgataatggc tgcagaaatg gaacagtcat ctggcacagg     1380

cccagcagaa ttaactcagt tttggaaaga agttcccaga aacaaagtga tggaacatag     1440

gttaagatgc catactgttg aaagcagtaa accaaacact cttacgttaa aagacaatgc     1500

tttcaatatg tcagataaaa ccagtgaaga tatatgtcta caatacagtt aaagaagtgg     1560

tgccgggtag gaaccacggt tccttcgtcc attagttgga aaaagtaaca gacctaaaac     1620

tctaccaagc tactaaaaac attgcacatc tgtgcttcct aaaaggaaat atgcagcacg     1680

tggaggggaa cacatacatg tcttgaaaat aaactgctag aataaagaaa tgctggagaa     1740

attgattata agagactata gctatttagt aaagtaagta aaggcatatc cattgtgtaa     1800

attaatagtt taaatataat ttattttttc cttttgatct gaatactttt aaagcttaag     1860

ttttatcgtg taaatacatt agctaaactg aaaagtataa gtaacatgct ttgttgcagc     1920

caaaaaatgt aatctgcttt tttatgacag aattattata gctgagctga cttactagct     1980

tttctatact atgtatatag aagaacatgt atattgagaa agaaaacata cttatataga     2040

ggaatttatg taaccatgac tttgtaattt tgagaattcc tcccagtgat ggtcagtatt     2100

cttttggaat gtaaaccgat ttaatgccaa accaccttaa cctttgtttc tcagtgttcc     2160

ttaacagcct gccttttatt aatctcaggc ttttttatga acactctcat ttcagtagaa     2220

tttggaaaac taagcgtggt tggaatttct ttgaattctg ttagtaatgc ccaaaagaaa     2280

agtctcaagc agtcccccta tccagtcatt tttatggagt ttcatgttgt ccactatagc     2340

tggacactga accttttgcc taatttatta taaaggcctg accctctatt gtcccatctt     2400

cacccccatt ccagagcaga ggagtctctg tggaccatga attgcactgt ctccctcctc     2460

atttctaaat gaaaggtatt agatataaat ttttttgaaa ggttagttgt ttgagatgct     2520

aagcaggata ataaatttag attttaaaat gttccctgta aaagtcagcc catgacaagg     2580

aaatttacaa aatactagag tatctagaag ggtgaaaaca aaaaaaaata aaaagaaaca     2640

cagacgccca ggtgtcagct ctccgtttaa agaatgaaaa atgtaactca tgatgatctg     2700

tgaaaccttc aaactaggac caattgactt acttgatatt ctgcctttga tatggtagta     2760

cccacccggt attcctaaaa tcctaaaaag atacaccttg cagtagcaga ggcaatgaca     2820

tgagtttgtt ttctcattaa tatgaccagt ttgggtctat gttggttcac atgtacatct     2880

actttatatg aaagaaaaaa cagttgtctg cctgtaaaat gttgagtttc gattgagcca     2940

tgtttggaga ttttattact attctgaagg gtagtgttgt tggttttcat cttcaagaag     3000

ttgattccaa aactgagtta tgaagaatga tataacagtt ccttcaaaat tggcctagga     3060

aataaaacct taaaaggaca ctggtgtgct actttgtctt aatttgggct tttctgtttc     3120

agtttgccac ctccagctgt gaaatggact gcagtccacc ctaagtactg tgcacagtat     3180

ctccctgtgt gtgtgcacag tggcttcccc ttacatggta gatttttggc cttaatataa     3240

tctaatccca aagtagttgt gtatgttttc tgttccttgg caaataaatg aagaaataat     3300

tagccaagat tgaaaatgta ttgtcctaac ggtgtccctt taatgtttca tatgaaaaat     3360

tatgttgacc cactaaaata tccttgctca atgtctggtc agttgaattt aataacatat     3420

cttgttaatg tttgtgtgtc tattaaatgt gactaagcag gattactgaa aattcactat     3480

aaaatcaaag gcatctaaac gtttgtactt gtcttgatta atcatatatt tacacttgat     3540

ttttttctgt cttcatttgt ttttatttaa tcataattgc atgatttttt tggtactcta     3600

atcagtaatt ttatttttaa tcatgtcatt acctattcat gaccaaatta ccaaggaacc     3660

aacatttaga tttagatatt tgttttcact taggaatgga aattaataga ttttccatga     3720

aagcattagt gaaatatcat taccttgatc tgcaagtagc ctaaaaatgc gattgctggt     3780

aaacctggcc tcaaatttca tactaccata actgttttta tatattgcca ctaattttga     3840

ctggatttaa tagcacttta ttgtacaact acaaaaaaaa atatattcct agaattgttg     3900

ccagtgtaa                                                             3909


<210>  9
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA hairpin sequence #1 for MOSPD2

<400>  9
ccggcccaga tggttattgg aaattctcga gatttccaat aaccatctgg gttttttg         58


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target sequence on MOSPD2 for shRNA hairpin sequence #1

<400>  10
cccagatggt tattggaaat t                                                 21


<210>  11
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA hairpin sequence #2 for MOSPD2

<400>  11
ccgggccata ctgttgaaag cagtactcga gtactgcttt caacagtatg gcttttttg        59


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MOSPD2 target sequence for shRNA hairpin sequence #2

<400>  12
gccatactgt tgaaagcagt a                                                 21


<210>  13
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA hairpin sequence #3 for MOSPD2

<400>  13
ccggccctcc tcatttctaa atgaactcga gttcatttag aaatgaggag ggttttttg        59


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MOSPD2 target sequence for shRNA hairpin sequence #3

<400>  14
ccctcctcat ttctaaatga a                                                 21


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hemagglutinin tag for MOSPD2

<400>  15

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   
