                         SEQUENCE LISTING

<110>  Universittsklinikum Heidelberg
 
<120>  Use of K2P Potassium Channel for Altering the Electrophysiology 
       of the Heart

<130>  789-11 PCT

<150>  EP 15 181 096.7
<151>  2015-08-14

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Pro Ser Ala Ser Arg Glu Arg Pro Gly Tyr Arg Ala Gly Val 
1               5                   10                  15      


Ala Ala Pro Asp Leu Leu Asp Pro Lys Ser Ala Ala Gln Asn Ser Lys 
            20                  25                  30          


Pro Arg Leu Ser Phe Ser Thr Lys Pro Thr Val Leu Ala Ser Arg Val 
        35                  40                  45              


Glu Ser Asp Thr Thr Ile Asn Val Met Lys Trp Lys Thr Val Ser Thr 
    50                  55                  60                  


Ile Phe Leu Val Val Val Leu Tyr Leu Ile Ile Gly Ala Thr Val Phe 
65                  70                  75                  80  


Lys Ala Leu Glu Gln Pro His Glu Ile Ser Gln Arg Thr Thr Ile Val 
                85                  90                  95      


Ile Gln Lys Gln Thr Phe Ile Ser Gln His Ser Cys Val Asn Ser Thr 
            100                 105                 110         


Glu Leu Asp Glu Leu Ile Gln Gln Ile Val Ala Ala Ile Asn Ala Gly 
        115                 120                 125             


Ile Ile Pro Leu Gly Asn Thr Ser Asn Gln Ile Ser His Trp Asp Leu 
    130                 135                 140                 


Gly Ser Ser Phe Phe Phe Ala Gly Thr Val Ile Thr Thr Ile Gly Phe 
145                 150                 155                 160 


Gly Asn Ile Ser Pro Arg Thr Glu Gly Gly Lys Ile Phe Cys Ile Ile 
                165                 170                 175     


Tyr Ala Leu Leu Gly Ile Pro Leu Phe Gly Phe Leu Leu Ala Gly Val 
            180                 185                 190         


Gly Asp Gln Leu Gly Thr Ile Phe Gly Lys Gly Ile Ala Lys Val Glu 
        195                 200                 205             


Asp Thr Phe Ile Lys Trp Asn Val Ser Gln Thr Lys Ile Arg Ile Ile 
    210                 215                 220                 


Ser Thr Ile Ile Phe Ile Leu Phe Gly Cys Val Leu Phe Val Ala Leu 
225                 230                 235                 240 


Pro Ala Ile Ile Phe Lys His Ile Glu Gly Trp Ser Ala Leu Asp Ala 
                245                 250                 255     


Ile Tyr Phe Val Val Ile Thr Leu Thr Thr Ile Gly Phe Gly Asp Tyr 
            260                 265                 270         


Val Ala Gly Gly Ser Asp Ile Glu Tyr Leu Asp Phe Tyr Lys Pro Val 
        275                 280                 285             


Val Trp Phe Trp Ile Leu Val Gly Leu Ala Tyr Phe Ala Ala Val Leu 
    290                 295                 300                 


Ser Met Ile Gly Asp Trp Leu Arg Val Ile Ser Lys Lys Thr Lys Glu 
305                 310                 315                 320 


Glu Val Gly Glu Phe Arg Ala His Ala Ala Glu Trp Thr Ala Asn Val 
                325                 330                 335     


Thr Ala Glu Phe Lys Glu Thr Arg Arg Arg Leu Ser Val Glu Ile Tyr 
            340                 345                 350         


Asp Lys Phe Gln Arg Ala Thr Ser Ile Lys Arg Lys Leu Ser Ala Glu 
        355                 360                 365             


Leu Ala Gly Asn His Asn Gln Glu Leu Thr Pro Cys Arg Arg Thr Leu 
    370                 375                 380                 


Ser Val Asn His Leu Thr Ser Glu Arg Asp Val Leu Pro Pro Leu Leu 
385                 390                 395                 400 


Lys Thr Glu Ser Ile Tyr Leu Asn Gly Leu Thr Pro His Cys Ala Gly 
                405                 410                 415     


Glu Glu Ile Ala Val Ile Glu Asn Ile Lys 
            420                 425     


<210>  2
<211>  1281
<212>  DNA
<213>  Homo sapiens

<400>  2
atgcttccca gcgcctcgcg ggagagaccc ggctatagag caggagtggc ggcacctgac       60

ttgctggatc ctaaatctgc cgctcagaac tccaaaccga ggctctcgtt ttccacgaaa      120

cccacagtgc ttgcttcccg ggtggagagt gacacgacca ttaatgttat gaaatggaag      180

acggtctcca cgatattcct ggtggttgtc ctctatctga tcatcggagc caccgtgttc      240

aaagcattgg agcagcctca tgagatttca cagaggacca ccattgtgat ccagaagcaa      300

acattcatat cccaacattc ctgtgtcaat tcgacggagc tggatgaact cattcagcaa      360

atagtggcag caataaatgc agggattata ccgttaggaa acacctccaa tcaaatcagt      420

cactgggatt tgggaagttc cttcttcttt gctggcactg ttattacaac cataggattt      480

ggaaacatct caccacgcac agaaggcggc aaaatattct gtatcatcta tgccttactg      540

ggaattcccc tctttggttt tctcttggct ggagttggag atcagctagg caccatattt      600

ggaaaaggaa ttgccaaagt ggaagatacg tttattaagt ggaatgttag tcagaccaag      660

attcgcatca tctcaacaat catatttata ctatttggct gtgtactctt tgtggctctg      720

cctgcgatca tattcaaaca catagaaggc tggagtgccc tggacgccat ttattttgtg      780

gttatcactc taacaactat tggatttggt gactacgttg caggtggatc cgatattgaa      840

tatctggact tctataagcc tgtcgtgtgg ttctggatcc ttgtagggct tgcttacttt      900

gctgctgtcc tgagcatgat tggagattgg ctccgagtga tatctaaaaa gacaaaagaa      960

gaggtgggag agttcagagc acacgctgct gagtggacag ccaacgtcac agccgaattc     1020

aaagaaacca ggaggcgact gagtgtggag atttatgaca agttccagcg ggccacctcc     1080

atcaagcgga agctctcggc agaactggct ggaaaccaca atcaggagct gactccttgt     1140

aggaggaccc tgtcagtgaa ccacctgacc agcgagaggg atgtcttgcc tcccttactg     1200

aagactgaga gtatctatct gaatggtttg acgccacact gtgctggtga agagattgct     1260

gtgattgaga acatcaaata g                                               1281


<210>  3
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Met Asn Pro Arg Ala Lys Arg Asp Phe Tyr Leu Ala Ala Pro Asp 
1               5                   10                  15      


Leu Leu Asp Pro Lys Ser Ala Ala Gln Asn Ser Lys Pro Arg Leu Ser 
            20                  25                  30          


Phe Ser Thr Lys Pro Thr Val Leu Ala Ser Arg Val Glu Ser Asp Thr 
        35                  40                  45              


Thr Ile Asn Val Met Lys Trp Lys Thr Val Ser Thr Ile Phe Leu Val 
    50                  55                  60                  


Val Val Leu Tyr Leu Ile Ile Gly Ala Thr Val Phe Lys Ala Leu Glu 
65                  70                  75                  80  


Gln Pro His Glu Ile Ser Gln Arg Thr Thr Ile Val Ile Gln Lys Gln 
                85                  90                  95      


Thr Phe Ile Ser Gln His Ser Cys Val Asn Ser Thr Glu Leu Asp Glu 
            100                 105                 110         


Leu Ile Gln Gln Ile Val Ala Ala Ile Asn Ala Gly Ile Ile Pro Leu 
        115                 120                 125             


Gly Asn Thr Ser Asn Gln Ile Ser His Trp Asp Leu Gly Ser Ser Phe 
    130                 135                 140                 


Phe Phe Ala Gly Thr Val Ile Thr Thr Ile Gly Phe Gly Asn Ile Ser 
145                 150                 155                 160 


Pro Arg Thr Glu Gly Gly Lys Ile Phe Cys Ile Ile Tyr Ala Leu Leu 
                165                 170                 175     


Gly Ile Pro Leu Phe Gly Phe Leu Leu Ala Gly Val Gly Asp Gln Leu 
            180                 185                 190         


Gly Thr Ile Phe Gly Lys Gly Ile Ala Lys Val Glu Asp Thr Phe Ile 
        195                 200                 205             


Lys Trp Asn Val Ser Gln Thr Lys Ile Arg Ile Ile Ser Thr Ile Ile 
    210                 215                 220                 


Phe Ile Leu Phe Gly Cys Val Leu Phe Val Ala Leu Pro Ala Ile Ile 
225                 230                 235                 240 


Phe Lys His Ile Glu Gly Trp Ser Ala Leu Asp Ala Ile Tyr Phe Val 
                245                 250                 255     


Val Ile Thr Leu Thr Thr Ile Gly Phe Gly Asp Tyr Val Ala Gly Gly 
            260                 265                 270         


Ser Asp Ile Glu Tyr Leu Asp Phe Tyr Lys Pro Val Val Trp Phe Trp 
        275                 280                 285             


Ile Leu Val Gly Leu Ala Tyr Phe Ala Ala Val Leu Ser Met Ile Gly 
    290                 295                 300                 


Asp Trp Leu Arg Val Ile Ser Lys Lys Thr Lys Glu Glu Val Gly Glu 
305                 310                 315                 320 


Phe Arg Ala His Ala Ala Glu Trp Thr Ala Asn Val Thr Ala Glu Phe 
                325                 330                 335     


Lys Glu Thr Arg Arg Arg Leu Ser Val Glu Ile Tyr Asp Lys Phe Gln 
            340                 345                 350         


Arg Ala Thr Ser Ile Lys Arg Lys Leu Ser Ala Glu Leu Ala Gly Asn 
        355                 360                 365             


His Asn Gln Glu Leu Thr Pro Cys Arg Arg Thr Leu Ser Val Asn His 
    370                 375                 380                 


Leu Thr Ser Glu Arg Asp Val Leu Pro Pro Leu Leu Lys Thr Glu Ser 
385                 390                 395                 400 


Ile Tyr Leu Asn Gly Leu Thr Pro His Cys Ala Gly Glu Glu Ile Ala 
                405                 410                 415     


Val Ile Glu Asn Ile Lys 
            420         


<210>  4
<211>  1269
<212>  DNA
<213>  Homo sapiens

<400>  4
atgatgaacc cacgagcaaa aagggatttc tacttggcgg cacctgactt gctggatcct       60

aaatctgccg ctcagaactc caaaccgagg ctctcgtttt ccacgaaacc cacagtgctt      120

gcttcccggg tggagagtga cacgaccatt aatgttatga aatggaagac ggtctccacg      180

atattcctgg tggttgtcct ctatctgatc atcggagcca ccgtgttcaa agcattggag      240

cagcctcatg agatttcaca gaggaccacc attgtgatcc agaagcaaac attcatatcc      300

caacattcct gtgtcaattc gacggagctg gatgaactca ttcagcaaat agtggcagca      360

ataaatgcag ggattatacc gttaggaaac acctccaatc aaatcagtca ctgggatttg      420

ggaagttcct tcttctttgc tggcactgtt attacaacca taggatttgg aaacatctca      480

ccacgcacag aaggcggcaa aatattctgt atcatctatg ccttactggg aattcccctc      540

tttggttttc tcttggctgg agttggagat cagctaggca ccatatttgg aaaaggaatt      600

gccaaagtgg aagatacgtt tattaagtgg aatgttagtc agaccaagat tcgcatcatc      660

tcaacaatca tatttatact atttggctgt gtactctttg tggctctgcc tgcgatcata      720

ttcaaacaca tagaaggctg gagtgccctg gacgccattt attttgtggt tatcactcta      780

acaactattg gatttggtga ctacgttgca ggtggatccg atattgaata tctggacttc      840

tataagcctg tcgtgtggtt ctggatcctt gtagggcttg cttactttgc tgctgtcctg      900

agcatgattg gagattggct ccgagtgata tctaaaaaga caaaagaaga ggtgggagag      960

ttcagagcac acgctgctga gtggacagcc aacgtcacag ccgaattcaa agaaaccagg     1020

aggcgactga gtgtggagat ttatgacaag ttccagcggg ccacctccat caagcggaag     1080

ctctcggcag aactggctgg aaaccacaat caggagctga ctccttgtag gaggaccctg     1140

tcagtgaacc acctgaccag cgagagggat gtcttgcctc ccttactgaa gactgagagt     1200

atctatctga atggtttgac gccacactgt gctggtgaag agattgctgt gattgagaac     1260

atcaaatag                                                             1269


<210>  5
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Ala Pro Asp Leu Leu Asp Pro Lys Ser Ala Ala Gln Asn Ser 
1               5                   10                  15      


Lys Pro Arg Leu Ser Phe Ser Thr Lys Pro Thr Val Leu Ala Ser Arg 
            20                  25                  30          


Val Glu Ser Asp Thr Thr Ile Asn Val Met Lys Trp Lys Thr Val Ser 
        35                  40                  45              


Thr Ile Phe Leu Val Val Val Leu Tyr Leu Ile Ile Gly Ala Thr Val 
    50                  55                  60                  


Phe Lys Ala Leu Glu Gln Pro His Glu Ile Ser Gln Arg Thr Thr Ile 
65                  70                  75                  80  


Val Ile Gln Lys Gln Thr Phe Ile Ser Gln His Ser Cys Val Asn Ser 
                85                  90                  95      


Thr Glu Leu Asp Glu Leu Ile Gln Gln Ile Val Ala Ala Ile Asn Ala 
            100                 105                 110         


Gly Ile Ile Pro Leu Gly Asn Thr Ser Asn Gln Ile Ser His Trp Asp 
        115                 120                 125             


Leu Gly Ser Ser Phe Phe Phe Ala Gly Thr Val Ile Thr Thr Ile Gly 
    130                 135                 140                 


Phe Gly Asn Ile Ser Pro Arg Thr Glu Gly Gly Lys Ile Phe Cys Ile 
145                 150                 155                 160 


Ile Tyr Ala Leu Leu Gly Ile Pro Leu Phe Gly Phe Leu Leu Ala Gly 
                165                 170                 175     


Val Gly Asp Gln Leu Gly Thr Ile Phe Gly Lys Gly Ile Ala Lys Val 
            180                 185                 190         


Glu Asp Thr Phe Ile Lys Trp Asn Val Ser Gln Thr Lys Ile Arg Ile 
        195                 200                 205             


Ile Ser Thr Ile Ile Phe Ile Leu Phe Gly Cys Val Leu Phe Val Ala 
    210                 215                 220                 


Leu Pro Ala Ile Ile Phe Lys His Ile Glu Gly Trp Ser Ala Leu Asp 
225                 230                 235                 240 


Ala Ile Tyr Phe Val Val Ile Thr Leu Thr Thr Ile Gly Phe Gly Asp 
                245                 250                 255     


Tyr Val Ala Gly Gly Ser Asp Ile Glu Tyr Leu Asp Phe Tyr Lys Pro 
            260                 265                 270         


Val Val Trp Phe Trp Ile Leu Val Gly Leu Ala Tyr Phe Ala Ala Val 
        275                 280                 285             


Leu Ser Met Ile Gly Asp Trp Leu Arg Val Ile Ser Lys Lys Thr Lys 
    290                 295                 300                 


Glu Glu Val Gly Glu Phe Arg Ala His Ala Ala Glu Trp Thr Ala Asn 
305                 310                 315                 320 


Val Thr Ala Glu Phe Lys Glu Thr Arg Arg Arg Leu Ser Val Glu Ile 
                325                 330                 335     


Tyr Asp Lys Phe Gln Arg Ala Thr Ser Ile Lys Arg Lys Leu Ser Ala 
            340                 345                 350         


Glu Leu Ala Gly Asn His Asn Gln Glu Leu Thr Pro Cys Arg Arg Thr 
        355                 360                 365             


Leu Ser Val Asn His Leu Thr Ser Glu Arg Asp Val Leu Pro Pro Leu 
    370                 375                 380                 


Leu Lys Thr Glu Ser Ile Tyr Leu Asn Gly Leu Thr Pro His Cys Ala 
385                 390                 395                 400 


Gly Glu Glu Ile Ala Val Ile Glu Asn Ile Lys 
                405                 410     


<210>  6
<211>  1236
<212>  DNA
<213>  Homo sapiens

<400>  6
atggcggcac ctgacttgct ggatcctaaa tctgccgctc agaactccaa accgaggctc       60

tcgttttcca cgaaacccac agtgcttgct tcccgggtgg agagtgacac gaccattaat      120

gttatgaaat ggaagacggt ctccacgata ttcctggtgg ttgtcctcta tctgatcatc      180

ggagccaccg tgttcaaagc attggagcag cctcatgaga tttcacagag gaccaccatt      240

gtgatccaga agcaaacatt catatcccaa cattcctgtg tcaattcgac ggagctggat      300

gaactcattc agcaaatagt ggcagcaata aatgcaggga ttataccgtt aggaaacacc      360

tccaatcaaa tcagtcactg ggatttggga agttccttct tctttgctgg cactgttatt      420

acaaccatag gatttggaaa catctcacca cgcacagaag gcggcaaaat attctgtatc      480

atctatgcct tactgggaat tcccctcttt ggttttctct tggctggagt tggagatcag      540

ctaggcacca tatttggaaa aggaattgcc aaagtggaag atacgtttat taagtggaat      600

gttagtcaga ccaagattcg catcatctca acaatcatat ttatactatt tggctgtgta      660

ctctttgtgg ctctgcctgc gatcatattc aaacacatag aaggctggag tgccctggac      720

gccatttatt ttgtggttat cactctaaca actattggat ttggtgacta cgttgcaggt      780

ggatccgata ttgaatatct ggacttctat aagcctgtcg tgtggttctg gatccttgta      840

gggcttgctt actttgctgc tgtcctgagc atgattggag attggctccg agtgatatct      900

aaaaagacaa aagaagaggt gggagagttc agagcacacg ctgctgagtg gacagccaac      960

gtcacagccg aattcaaaga aaccaggagg cgactgagtg tggagattta tgacaagttc     1020

cagcgggcca cctccatcaa gcggaagctc tcggcagaac tggctggaaa ccacaatcag     1080

gagctgactc cttgtaggag gaccctgtca gtgaaccacc tgaccagcga gagggatgtc     1140

ttgcctccct tactgaagac tgagagtatc tatctgaatg gtttgacgcc acactgtgct     1200

ggtgaagaga ttgctgtgat tgagaacatc aaatag                               1236


<210>  7
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Leu Gln Ser Leu Ala Gly Ser Ser Cys Val Arg Leu Val Glu Arg 
1               5                   10                  15      


His Arg Ser Ala Trp Cys Phe Gly Phe Leu Val Leu Gly Tyr Leu Leu 
            20                  25                  30          


Tyr Leu Val Phe Gly Ala Val Val Phe Ser Ser Val Glu Leu Pro Tyr 
        35                  40                  45              


Glu Asp Leu Leu Arg Gln Glu Leu Arg Lys Leu Lys Arg Arg Phe Leu 
    50                  55                  60                  


Glu Glu His Glu Cys Leu Ser Glu Gln Gln Leu Glu Gln Phe Leu Gly 
65                  70                  75                  80  


Arg Val Leu Glu Ala Ser Asn Tyr Gly Val Ser Val Leu Ser Asn Ala 
                85                  90                  95      


Ser Gly Asn Trp Asn Trp Asp Phe Thr Ser Ala Leu Phe Phe Ala Ser 
            100                 105                 110         


Thr Val Leu Ser Thr Thr Gly Tyr Gly His Thr Val Pro Leu Ser Asp 
        115                 120                 125             


Gly Gly Lys Ala Phe Cys Ile Ile Tyr Ser Val Ile Gly Ile Pro Phe 
    130                 135                 140                 


Thr Leu Leu Phe Leu Thr Ala Val Val Gln Arg Ile Thr Val His Val 
145                 150                 155                 160 


Thr Arg Arg Pro Val Leu Tyr Phe His Ile Arg Trp Gly Phe Ser Lys 
                165                 170                 175     


Gln Val Val Ala Ile Val His Ala Val Leu Leu Gly Phe Val Thr Val 
            180                 185                 190         


Ser Cys Phe Phe Phe Ile Pro Ala Ala Val Phe Ser Val Leu Glu Asp 
        195                 200                 205             


Asp Trp Asn Phe Leu Glu Ser Phe Tyr Phe Cys Phe Ile Ser Leu Ser 
    210                 215                 220                 


Thr Ile Gly Leu Gly Asp Tyr Val Pro Gly Glu Gly Tyr Asn Gln Lys 
225                 230                 235                 240 


Phe Arg Glu Leu Tyr Lys Ile Gly Ile Thr Cys Tyr Leu Leu Leu Gly 
                245                 250                 255     


Leu Ile Ala Met Leu Val Val Leu Glu Thr Phe Cys Glu Leu His Glu 
            260                 265                 270         


Leu Lys Lys Phe Arg Lys Met Phe Tyr Val Lys Lys Asp Lys Asp Glu 
        275                 280                 285             


Asp Gln Val His Ile Ile Glu His Asp Gln Leu Ser Phe Ser Ser Ile 
    290                 295                 300                 


Thr Asp Gln Ala Ala Gly Met Lys Glu Asp Gln Lys Gln Asn Glu Pro 
305                 310                 315                 320 


Phe Val Ala Thr Gln Ser Ser Ala Cys Val Asp Gly Pro Ala Asn His 
                325                 330                 335     


<210>  8
<211>  1011
<212>  DNA
<213>  Homo sapiens

<400>  8
atgctgcagt ccctggccgg cagctcgtgc gtgcgcctgg tggagcggca ccgctcggcc       60

tggtgcttcg gcttcctggt gctgggctac ttgctctacc tggtcttcgg cgcagtggtc      120

ttctcctcgg tggagctgcc ctatgaggac ctgctgcgcc aggagctgcg caagctgaag      180

cgacgcttct tggaggagca cgagtgcctg tctgagcagc agctggagca gttcctgggc      240

cgggtgctgg aggccagcaa ctacggcgtg tcggtgctca gcaacgcctc gggcaactgg      300

aactgggact tcacctccgc gctcttcttc gccagcaccg tgctctccac cacaggttat      360

ggccacaccg tgcccttgtc agatggaggt aaggccttct gcatcatcta ctccgtcatt      420

ggcattccct tcaccctcct gttcctgacg gctgtggtcc agcgcatcac cgtgcacgtc      480

acccgcaggc cggtcctcta cttccacatc cgctggggct tctccaagca ggtggtggcc      540

atcgtccatg ccgtgctcct tgggtttgtc actgtgtcct gcttcttctt catcccggcc      600

gctgtcttct cagtcctgga ggatgactgg aacttcctgg aatcctttta tttttgtttt      660

atttccctga gcaccattgg cctgggggat tatgtgcctg gggaaggcta caatcaaaaa      720

ttcagagagc tctataagat tgggatcacg tgttacctgc tacttggcct tattgccatg      780

ttggtagttc tggaaacctt ctgtgaactc catgagctga aaaaattcag aaaaatgttc      840

tatgtgaaga aggacaagga cgaggatcag gtgcacatca tagagcatga ccaactgtcc      900

ttctcctcga tcacagacca ggcagctggc atgaaagagg accagaagca aaatgagcct      960

tttgtggcca cccagtcatc tgcctgcgtg gatggccctg caaaccattg a              1011


<210>  9
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Lys Arg Gln Asn Val Arg Thr Leu Ala Leu Ile Val Cys Thr Phe 
1               5                   10                  15      


Thr Tyr Leu Leu Val Gly Ala Ala Val Phe Asp Ala Leu Glu Ser Glu 
            20                  25                  30          


Pro Glu Leu Ile Glu Arg Gln Arg Leu Glu Leu Arg Gln Gln Glu Leu 
        35                  40                  45              


Arg Ala Arg Tyr Asn Leu Ser Gln Gly Gly Tyr Glu Glu Leu Glu Arg 
    50                  55                  60                  


Val Val Leu Arg Leu Lys Pro His Lys Ala Gly Val Gln Trp Arg Phe 
65                  70                  75                  80  


Ala Gly Ser Phe Tyr Phe Ala Ile Thr Val Ile Thr Thr Ile Gly Tyr 
                85                  90                  95      


Gly His Ala Ala Pro Ser Thr Asp Gly Gly Lys Val Phe Cys Met Phe 
            100                 105                 110         


Tyr Ala Leu Leu Gly Ile Pro Leu Thr Leu Val Met Phe Gln Ser Leu 
        115                 120                 125             


Gly Glu Arg Ile Asn Thr Leu Val Arg Tyr Leu Leu His Arg Ala Lys 
    130                 135                 140                 


Lys Gly Leu Gly Met Arg Arg Ala Asp Val Ser Met Ala Asn Met Val 
145                 150                 155                 160 


Leu Ile Gly Phe Phe Ser Cys Ile Ser Thr Leu Cys Ile Gly Ala Ala 
                165                 170                 175     


Ala Phe Ser His Tyr Glu His Trp Thr Phe Phe Gln Ala Tyr Tyr Tyr 
            180                 185                 190         


Cys Phe Ile Thr Leu Thr Thr Ile Gly Phe Gly Asp Tyr Val Ala Leu 
        195                 200                 205             


Gln Lys Asp Gln Ala Leu Gln Thr Gln Pro Gln Tyr Val Ala Phe Ser 
    210                 215                 220                 


Phe Val Tyr Ile Leu Thr Gly Leu Thr Val Ile Gly Ala Phe Leu Asn 
225                 230                 235                 240 


Leu Val Val Leu Arg Phe Met Thr Met Asn Ala Glu Asp Glu Lys Arg 
                245                 250                 255     


Asp Ala Glu His Arg Ala Leu Leu Thr Arg Asn Gly Gln Ala Gly Gly 
            260                 265                 270         


Gly Gly Gly Gly Gly Ser Ala His Thr Thr Asp Thr Ala Ser Ser Thr 
        275                 280                 285             


Ala Ala Ala Gly Gly Gly Gly Phe Arg Asn Val Tyr Ala Glu Val Leu 
    290                 295                 300                 


His Phe Gln Ser Met Cys Ser Cys Leu Trp Tyr Lys Ser Arg Glu Lys 
305                 310                 315                 320 


Leu Gln Tyr Ser Ile Pro Met Ile Ile Pro Arg Asp Leu Ser Thr Ser 
                325                 330                 335     


Asp Thr Cys Val Glu Gln Ser His Ser Ser Pro Gly Gly Gly Gly Arg 
            340                 345                 350         


Tyr Ser Asp Thr Pro Ser Arg Arg Cys Leu Cys Ser Gly Ala Pro Arg 
        355                 360                 365             


Ser Ala Ile Ser Ser Val Ser Thr Gly Leu His Ser Leu Ser Thr Phe 
    370                 375                 380                 


Arg Gly Leu Met Lys Arg Arg Ser Ser Val 
385                 390                 


<210>  10
<211>  1185
<212>  DNA
<213>  Homo sapiens

<400>  10
atgaagcggc agaacgtgcg cacgctggcg ctcatcgtgt gcaccttcac ctacctgctg       60

gtgggcgccg cggtcttcga cgcgctggag tcggagcccg agctgatcga gcggcagcgg      120

ctggagctgc ggcagcagga gctgcgggcg cgctacaacc tcagccaggg cggctacgag      180

gagctggagc gcgtcgtgct gcgcctcaag ccgcacaagg ccggcgtgca gtggcgcttc      240

gccggctcct tctacttcgc catcaccgtc atcaccacca tcggctacgg gcacgcggca      300

cccagcacgg atggcggcaa ggtgttctgc atgttctacg cgctgctggg catcccgctc      360

acgctcgtca tgttccagag cctgggcgag cgcatcaaca ccttggtgag gtacctgctg      420

caccgcgcca agaaggggct gggcatgcgg cgcgccgacg tgtccatggc caacatggtg      480

ctcatcggct tcttctcgtg catcagcacg ctgtgcatcg gcgccgccgc cttctcccac      540

tacgagcact ggaccttctt ccaggcctac tactactgct tcatcaccct caccaccatc      600

ggcttcggcg actacgtggc gctgcagaag gaccaggccc tgcagacgca gccgcagtac      660

gtggccttca gcttcgtcta catccttacg ggcctcacgg tcatcggcgc cttcctcaac      720

ctcgtggtgc tgcgcttcat gaccatgaac gccgaggacg agaagcgcga cgccgagcac      780

cgcgcgctgc tcacgcgcaa cgggcaggcg ggcggcggcg gagggggtgg cagcgcgcac      840

actacggaca ccgcctcatc cacggcggca gcgggcggcg gcggcttccg caacgtctac      900

gcggaggtgc tgcacttcca gtccatgtgc tcgtgcctgt ggtacaagag ccgcgagaag      960

ctgcagtact ccatccccat gatcatcccg cgggacctct ccacgtccga cacgtgcgtg     1020

gagcagagcc actcgtcgcc gggagggggc ggccgctaca gcgacacgcc ctcgcgacgc     1080

tgcctgtgca gcggggcgcc acgctccgcc atcagctcgg tgtccacggg tctgcacagc     1140

ctgtccacct tccgcggcct catgaagcgc aggagctccg tgtga                     1185


<210>  11
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Arg Ser Thr Thr Leu Leu Ala Leu Leu Ala Leu Val Leu Leu Tyr 
1               5                   10                  15      


Leu Val Ser Gly Ala Leu Val Phe Arg Ala Leu Glu Gln Pro His Glu 
            20                  25                  30          


Gln Gln Ala Gln Arg Glu Leu Gly Glu Val Arg Glu Lys Phe Leu Arg 
        35                  40                  45              


Ala His Pro Cys Val Ser Asp Gln Glu Leu Gly Leu Leu Ile Lys Glu 
    50                  55                  60                  


Val Ala Asp Ala Leu Gly Gly Gly Ala Asp Pro Glu Thr Asn Ser Thr 
65                  70                  75                  80  


Ser Asn Ser Ser His Ser Ala Trp Asp Leu Gly Ser Ala Phe Phe Phe 
                85                  90                  95      


Ser Gly Thr Ile Ile Thr Thr Ile Gly Tyr Gly Asn Val Ala Leu Arg 
            100                 105                 110         


Thr Asp Ala Gly Arg Leu Phe Cys Ile Phe Tyr Ala Leu Val Gly Ile 
        115                 120                 125             


Pro Leu Phe Gly Ile Leu Leu Ala Gly Val Gly Asp Arg Leu Gly Ser 
    130                 135                 140                 


Ser Leu Arg His Gly Ile Gly His Ile Glu Ala Ile Phe Leu Lys Trp 
145                 150                 155                 160 


His Val Pro Pro Glu Leu Val Arg Val Leu Ser Ala Met Leu Phe Leu 
                165                 170                 175     


Leu Ile Gly Cys Leu Leu Phe Val Leu Thr Pro Thr Phe Val Phe Cys 
            180                 185                 190         


Tyr Met Glu Asp Trp Ser Lys Leu Glu Ala Ile Tyr Phe Val Ile Val 
        195                 200                 205             


Thr Leu Thr Thr Val Gly Phe Gly Asp Tyr Val Ala Gly Ala Asp Pro 
    210                 215                 220                 


Arg Gln Asp Ser Pro Ala Tyr Gln Pro Leu Val Trp Phe Trp Ile Leu 
225                 230                 235                 240 


Leu Gly Leu Ala Tyr Phe Ala Ser Val Leu Thr Thr Ile Gly Asn Trp 
                245                 250                 255     


Leu Arg Val Val Ser Arg Arg Thr Arg Ala Glu Met Gly Gly Leu Thr 
            260                 265                 270         


Ala Gln Ala Ala Ser Trp Thr Gly Thr Val Thr Ala Arg Val Thr Gln 
        275                 280                 285             


Arg Ala Gly Pro Ala Ala Pro Pro Pro Glu Lys Glu Gln Pro Leu Leu 
    290                 295                 300                 


Pro Pro Pro Pro Cys Pro Ala Gln Pro Leu Gly Arg Pro Arg Ser Pro 
305                 310                 315                 320 


Ser Pro Pro Glu Lys Ala Gln Pro Pro Ser Pro Pro Thr Ala Ser Ala 
                325                 330                 335     


Leu Asp Tyr Pro Ser Glu Asn Leu Ala Phe Ile Asp Glu Ser Ser Asp 
            340                 345                 350         


Thr Gln Ser Glu Arg Gly Cys Pro Leu Pro Arg Ala Pro Arg Gly Arg 
        355                 360                 365             


Arg Arg Pro Asn Pro Pro Arg Lys Pro Val Arg Pro Arg Gly Pro Gly 
    370                 375                 380                 


Arg Pro Arg Asp Lys Gly Val Pro Val 
385                 390             


<210>  12
<211>  1182
<212>  DNA
<213>  Homo sapiens

<400>  12
atgcgcagca ccacgctcct ggccctgctg gcgctggtct tgctttactt ggtgtctggt       60

gccctggtgt tccgggccct ggagcagccc cacgagcagc aggcccagag ggagctgggg      120

gaggtccgag agaagttcct gagggcccat ccgtgtgtga gcgaccagga gctgggcctc      180

ctcatcaagg aggtggctga tgccctggga gggggtgcgg acccagaaac caactcgacc      240

agcaacagca gccactcagc ctgggacctg ggcagcgcct tctttttctc agggaccatc      300

atcaccacca tcggctatgg caatgtggcc ctgcgcacag atgccgggcg cctcttctgc      360

atcttttatg cgctggtggg gattccgctg tttgggatcc tactggcagg ggtcggggac      420

cggctgggct cctccctgcg ccatggcatc ggtcacattg aagccatctt cttgaagtgg      480

cacgtgccac cggagctagt aagagtgctg tcggcgatgc ttttcctgct gatcggctgc      540

ctgctctttg tcctcacgcc cacgttcgtg ttctgctata tggaggactg gagcaagctg      600

gaggccatct actttgtcat agtgacgctt accaccgtgg gctttggcga ctatgtggcc      660

ggcgcggacc ccaggcagga ctccccggcc tatcagccgc tggtgtggtt ctggatcctg      720

ctcggcctgg cttacttcgc ctcagtgctc accaccatcg ggaactggct gcgagtagtg      780

tcccgccgca ctcgggcaga gatgggcggc ctcacggctc aggctgccag ctggactggc      840

acggtgacag cgcgcgtgac ccagcgagcc gggcccgccg ccccgccgcc ggagaaggag      900

cagccactgc tgcctccacc gccctgtcca gcgcagccgc tgggcaggcc ccgatcccct      960

tcgccccccg agaaggctca gccgccttcc ccgcccacgg cctcggccct ggattatccc     1020

agcgagaacc tggccttcat cgacgagtcc tcggatacgc agagcgagcg cggctgcccg     1080

ctgccccgcg cgccgagagg tcgccgccgc ccaaatcccc ccaggaagcc cgtgcggccc     1140

cgcggccccg ggcgtccccg agacaaaggc gtgccggtgt ag                        1182


<210>  13
<211>  499
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Val Asp Arg Gly Pro Leu Leu Thr Ser Ala Ile Ile Phe Tyr Leu 
1               5                   10                  15      


Ala Ile Gly Ala Ala Ile Phe Glu Val Leu Glu Glu Pro His Trp Lys 
            20                  25                  30          


Glu Ala Lys Lys Asn Tyr Tyr Thr Gln Lys Leu His Leu Leu Lys Glu 
        35                  40                  45              


Phe Pro Cys Leu Gly Gln Glu Gly Leu Asp Lys Ile Leu Glu Val Val 
    50                  55                  60                  


Ser Asp Ala Ala Gly Gln Gly Val Ala Ile Thr Gly Asn Gln Thr Phe 
65                  70                  75                  80  


Asn Asn Trp Asn Trp Pro Asn Ala Met Ile Phe Ala Ala Thr Val Ile 
                85                  90                  95      


Thr Thr Ile Gly Tyr Gly Asn Val Ala Pro Lys Thr Pro Ala Gly Arg 
            100                 105                 110         


Leu Phe Cys Val Phe Tyr Gly Leu Phe Gly Val Pro Leu Cys Leu Thr 
        115                 120                 125             


Trp Ile Ser Ala Leu Gly Lys Phe Phe Gly Gly Arg Ala Lys Arg Leu 
    130                 135                 140                 


Gly Gln Phe Leu Thr Lys Arg Gly Val Ser Leu Arg Lys Ala Gln Ile 
145                 150                 155                 160 


Thr Cys Thr Val Ile Phe Ile Val Trp Gly Val Leu Val His Leu Val 
                165                 170                 175     


Ile Pro Pro Phe Val Phe Met Val Thr Glu Gly Trp Asn Tyr Ile Glu 
            180                 185                 190         


Gly Leu Tyr Tyr Ser Phe Ile Thr Ile Ser Thr Ile Gly Phe Gly Asp 
        195                 200                 205             


Phe Val Ala Gly Val Asn Pro Ser Ala Asn Tyr His Ala Leu Tyr Arg 
    210                 215                 220                 


Tyr Phe Val Glu Leu Trp Ile Tyr Leu Gly Leu Ala Trp Leu Ser Leu 
225                 230                 235                 240 


Phe Val Asn Trp Lys Val Ser Met Phe Val Glu Val His Lys Ala Ile 
                245                 250                 255     


Lys Lys Arg Arg Arg Arg Arg Lys Glu Ser Phe Glu Ser Ser Pro His 
            260                 265                 270         


Ser Arg Lys Ala Leu Gln Val Lys Gly Ser Thr Ala Ser Lys Asp Val 
        275                 280                 285             


Asn Ile Phe Ser Phe Leu Ser Lys Lys Glu Glu Thr Tyr Asn Asp Leu 
    290                 295                 300                 


Ile Lys Gln Ile Gly Lys Lys Ala Met Lys Thr Ser Gly Gly Gly Glu 
305                 310                 315                 320 


Thr Gly Pro Gly Pro Gly Leu Gly Pro Gln Gly Gly Gly Leu Pro Ala 
                325                 330                 335     


Leu Pro Pro Ser Leu Val Pro Leu Val Val Tyr Ser Lys Asn Arg Val 
            340                 345                 350         


Pro Thr Leu Glu Glu Val Ser Gln Thr Leu Arg Ser Lys Gly His Val 
        355                 360                 365             


Ser Arg Ser Pro Asp Glu Glu Ala Val Ala Arg Ala Pro Glu Asp Ser 
    370                 375                 380                 


Ser Pro Ala Pro Glu Val Phe Met Asn Gln Leu Asp Arg Ile Ser Glu 
385                 390                 395                 400 


Glu Cys Glu Pro Trp Asp Ala Gln Asp Tyr His Pro Leu Ile Phe Gln 
                405                 410                 415     


Asp Ala Ser Ile Thr Phe Val Asn Thr Glu Ala Gly Leu Ser Asp Glu 
            420                 425                 430         


Glu Thr Ser Lys Ser Ser Leu Glu Asp Asn Leu Ala Gly Glu Glu Ser 
        435                 440                 445             


Pro Gln Gln Gly Ala Glu Ala Lys Ala Pro Leu Asn Met Gly Glu Phe 
    450                 455                 460                 


Pro Ser Ser Ser Glu Ser Thr Phe Thr Ser Thr Glu Ser Glu Leu Ser 
465                 470                 475                 480 


Val Pro Tyr Glu Gln Leu Met Asn Glu Tyr Asn Lys Ala Asn Ser Pro 
                485                 490                 495     


Lys Gly Thr 
            


<210>  14
<211>  1500
<212>  DNA
<213>  Homo sapiens

<400>  14
atggtggacc ggggccctct gctcacctcg gccatcatct tctacctggc catcggggcg       60

gcgatcttcg aagtgctgga ggagccacac tggaaggagg ccaagaaaaa ctactacaca      120

cagaagctgc atctgctcaa ggagttcccg tgcctgggtc aggagggcct ggacaagatc      180

ctagaggtgg tatctgatgc tgcaggacag ggtgtggcca tcacagggaa ccagaccttc      240

aacaactgga actggcccaa tgcaatgatt tttgcagcga ccgtcattac caccattgga      300

tatggcaatg tggctcccaa gacccccgcc ggtcgcctct tctgtgtttt ctatggtctc      360

ttcggggtgc cgctctgcct gacgtggatc agtgccctgg gcaagttctt cgggggacgt      420

gccaagagac tagggcagtt ccttaccaag agaggtgtga gtctgcggaa ggcgcagatc      480

acgtgcacag tcatcttcat cgtgtggggc gtcctagtcc acctggtgat cccacccttc      540

gtattcatgg tgactgaggg gtggaactac atcgagggcc tctactactc cttcatcacc      600

atctccacca tcggcttcgg tgactttgtg gccggtgtga accccagcgc caactaccac      660

gccctgtacc gctacttcgt ggagctctgg atctacttgg ggctggcctg gctgtccctt      720

tttgtcaact ggaaggtgag catgtttgtg gaagtccaca aagccattaa gaagcggcgg      780

cggcgacgga aggagtcctt tgagagctcc ccacactccc ggaaggccct gcaggtgaag      840

gggagcacag cctccaagga cgtcaacatc ttcagctttc tttccaagaa ggaagagacc      900

tacaacgacc tcatcaagca gatcgggaag aaggccatga agacaagcgg gggtggggag      960

acgggcccgg gcccagggct ggggcctcaa ggcggtgggc tcccagcact gcccccttcc     1020

ctggtgcccc tggtagtcta ctccaagaac cgggtgccca ccttggaaga ggtgtcacag     1080

acactgagga gcaaaggcca cgtatcaagg tccccagatg aggaggctgt ggcacgggcc     1140

cctgaagaca gctcccctgc ccccgaggtg ttcatgaacc agctggaccg catcagcgag     1200

gaatgcgagc catgggacgc ccaggactac cacccactca tcttccagga cgccagcatc     1260

accttcgtga acacggaggc tggcctctca gacgaggaga cctccaagtc ctcgctagag     1320

gacaacttgg caggggagga gagcccccag cagggggctg aagccaaggc gcccctgaac     1380

atgggcgagt tcccctcctc ctccgagtcc accttcacca gcactgagtc tgagctctct     1440

gtgccttacg aacagctgat gaatgagtac aacaaggcta acagccccaa gggcacatga     1500


<210>  15
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Arg Arg Gly Ala Leu Leu Ala Gly Ala Leu Ala Ala Tyr Ala Ala 
1               5                   10                  15      


Tyr Leu Val Leu Gly Ala Leu Leu Val Ala Arg Leu Glu Gly Pro His 
            20                  25                  30          


Glu Ala Arg Leu Arg Ala Glu Leu Glu Thr Leu Arg Ala Gln Leu Leu 
        35                  40                  45              


Gln Arg Ser Pro Cys Val Ala Ala Pro Ala Leu Asp Ala Phe Val Glu 
    50                  55                  60                  


Arg Val Leu Ala Ala Gly Arg Leu Gly Arg Val Val Leu Ala Asn Ala 
65                  70                  75                  80  


Ser Gly Ser Ala Asn Ala Ser Asp Pro Ala Trp Asp Phe Ala Ser Ala 
                85                  90                  95      


Leu Phe Phe Ala Ser Thr Leu Ile Thr Thr Val Gly Tyr Gly Tyr Thr 
            100                 105                 110         


Thr Pro Leu Thr Asp Ala Gly Lys Ala Phe Ser Ile Ala Phe Ala Leu 
        115                 120                 125             


Leu Gly Val Pro Thr Thr Met Leu Leu Leu Thr Ala Ser Ala Gln Arg 
    130                 135                 140                 


Leu Ser Leu Leu Leu Thr His Val Pro Leu Ser Trp Leu Ser Met Arg 
145                 150                 155                 160 


Trp Gly Trp Asp Pro Arg Arg Ala Ala Cys Trp His Leu Val Ala Leu 
                165                 170                 175     


Leu Gly Val Val Val Thr Val Cys Phe Leu Val Pro Ala Val Ile Phe 
            180                 185                 190         


Ala His Leu Glu Glu Ala Trp Ser Phe Leu Asp Ala Phe Tyr Phe Cys 
        195                 200                 205             


Phe Ile Ser Leu Ser Thr Ile Gly Leu Gly Asp Tyr Val Pro Gly Glu 
    210                 215                 220                 


Ala Pro Gly Gln Pro Tyr Arg Ala Leu Tyr Lys Val Leu Val Thr Val 
225                 230                 235                 240 


Tyr Leu Phe Leu Gly Leu Val Ala Met Val Leu Val Leu Gln Thr Phe 
                245                 250                 255     


Arg His Val Ser Asp Leu His Gly Leu Thr Glu Leu Ile Leu Leu Pro 
            260                 265                 270         


Pro Pro Cys Pro Ala Ser Phe Asn Ala Asp Glu Asp Asp Arg Val Asp 
        275                 280                 285             


Ile Leu Gly Pro Gln Pro Glu Ser His Gln Gln Leu Ser Ala Ser Ser 
    290                 295                 300                 


His Thr Asp Tyr Ala Ser Ile Pro Arg 
305                 310             


<210>  16
<211>  942
<212>  DNA
<213>  Homo sapiens

<400>  16
atgcggaggg gcgcgcttct ggcgggcgcc ttggccgcgt acgccgcgta cctggtgctg       60

ggcgcgctgt tggtggcgcg gctggagggg ccgcacgaag ccaggctccg agccgagctg      120

gagacgctgc gggcgcagct gcttcagcgc agcccgtgtg tggctgcccc cgccctggac      180

gccttcgtgg agcgagtgct ggcggccgga cggctggggc gggtcgtgct tgctaacgct      240

tcggggtccg ccaacgcctc ggaccccgcc tgggacttcg cctctgctct cttcttcgcc      300

agcacgctga tcaccaccgt gggctatggg tacacaacgc cactgactga tgcgggcaag      360

gccttctcca tcgcctttgc gctcctgggc gtgccgacca ccatgctgct gctgaccgcc      420

tcagcccagc gcctgtcact gctgctgact cacgtgcccc tgtcttggct gagcatgcgt      480

tggggctggg acccccggcg ggcggcctgc tggcacttgg tggccctgtt gggggtcgta      540

gtgaccgtct gctttctggt gccggctgtg atctttgccc acctcgagga ggcctggagc      600

ttcttggatg ccttctactt ctgctttatc tctctgtcca ccatcggcct gggcgactac      660

gtgcccgggg aggcccctgg ccagccctac cgggccctct acaaggtgct ggtcacagtc      720

tacctcttcc tgggcctggt ggccatggtg ctggtgctgc agaccttccg ccacgtgtcc      780

gacctccacg gcctcacgga gctcatcctg ctgccccctc cgtgccctgc cagtttcaat      840

gcggatgagg acgatcgggt ggacatcctg ggcccccagc cggagtcgca ccagcaactc      900

tctgccagct cccacaccga ctacgcttcc atccccaggt ag                         942


<210>  17
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Gly Gly Leu Arg Pro Trp Ser Arg Tyr Gly Leu Leu Val Val Ala 
1               5                   10                  15      


His Leu Leu Ala Leu Gly Leu Gly Ala Val Val Phe Gln Ala Leu Glu 
            20                  25                  30          


Gly Pro Pro Ala Cys Arg Leu Gln Ala Glu Leu Arg Ala Glu Leu Ala 
        35                  40                  45              


Ala Phe Gln Ala Glu His Arg Ala Cys Leu Pro Pro Gly Ala Leu Glu 
    50                  55                  60                  


Glu Leu Leu Gly Thr Ala Leu Ala Thr Gln Ala His Gly Val Ser Thr 
65                  70                  75                  80  


Leu Gly Asn Ser Ser Glu Gly Arg Thr Trp Asp Leu Pro Ser Ala Leu 
                85                  90                  95      


Leu Phe Ala Ala Ser Ile Leu Thr Thr Thr Gly Tyr Gly His Met Ala 
            100                 105                 110         


Pro Leu Ser Pro Gly Gly Lys Ala Phe Cys Met Val Tyr Ala Ala Leu 
        115                 120                 125             


Gly Leu Pro Ala Ser Leu Ala Leu Val Ala Thr Leu Arg His Cys Leu 
    130                 135                 140                 


Leu Pro Val Leu Ser Arg Pro Arg Ala Trp Val Ala Val His Trp Gln 
145                 150                 155                 160 


Leu Ser Pro Ala Arg Ala Ala Leu Leu Gln Ala Val Ala Leu Gly Leu 
                165                 170                 175     


Leu Val Ala Ser Ser Phe Val Leu Leu Pro Ala Leu Val Leu Trp Gly 
            180                 185                 190         


Leu Gln Gly Asp Cys Ser Leu Leu Gly Ala Val Tyr Phe Cys Phe Ser 
        195                 200                 205             


Ser Leu Ser Thr Ile Gly Leu Glu Asp Leu Leu Pro Gly Arg Gly Arg 
    210                 215                 220                 


Ser Leu His Pro Val Ile Tyr His Leu Gly Gln Leu Ala Leu Leu Gly 
225                 230                 235                 240 


Tyr Leu Leu Leu Gly Leu Leu Ala Met Leu Leu Ala Val Glu Thr Phe 
                245                 250                 255     


Ser Glu Leu Pro Gln Val Arg Ala Met Gly Lys Phe Phe Arg Pro Ser 
            260                 265                 270         


Gly Pro Val Thr Ala Glu Asp Gln Gly Gly Ile Leu Gly Gln Asp Glu 
        275                 280                 285             


Leu Ala Leu Ser Thr Leu Pro Pro Ala Ala Pro Ala Ser Gly Gln Ala 
    290                 295                 300                 


Pro Ala Cys 
305         


<210>  18
<211>  924
<212>  DNA
<213>  Homo sapiens

<400>  18
atggggggtc taaggccctg gtcccgatac gggctcctgg ttgtggccca cttgctggcc       60

ctggggcttg gggctgtggt gttccaggcc ctggaggggc ctcctgcatg caggcttcag      120

gctgagctca gggcagagct ggcagccttc caggcagagc atagggcctg cctgccaccc      180

ggagctctgg aagagctgct gggcactgcc ctggccaccc aggcccatgg ggtctccacc      240

ctgggcaaca gctcagaggg caggacctgg gaccttccct cagccctgct cttcgctgcc      300

agcatcctca ccaccacagg ttatggccac atggccccac tatcgccagg cggaaaggcc      360

ttctgcatgg tctatgcagc cctggggctg ccagcctcct tagctctcgt ggccaccctg      420

cgccattgcc tgctgcctgt gctcagccgc ccacgtgcct gggtagcggt ccactggcag      480

ctgtcaccgg ccagggctgc gctgctgcag gcagttgcac tgggactgct ggtggccagc      540

agctttgtgc tgctgccagc gctggtgctg tggggccttc agggcgactg cagcctgctg      600

ggggccgtct acttctgctt cagctcgctc agcaccattg gcctggagga cttgctgccc      660

ggccgcggcc gcagcctgca ccccgtgatt taccacctgg gccagctcgc acttcttggt      720

tacttgcttc taggactctt ggccatgctg ctggcagtgg agaccttctc tgagctgccg      780

caggtccgtg ccatggggaa gttcttcaga cccagtggtc ctgtgactgc tgaggaccaa      840

ggtggcatcc tagggcagga tgaactggct ctgagcaccc tgccgcccgc ggccccagct      900

tcaggacaag cccctgcttg ctga                                             924


<210>  19
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Lys Arg Gln Asn Val Arg Thr Leu Ser Leu Ile Val Cys Thr Phe 
1               5                   10                  15      


Thr Tyr Leu Leu Val Gly Ala Ala Val Phe Asp Ala Leu Glu Ser Asp 
            20                  25                  30          


His Glu Met Arg Glu Glu Glu Lys Leu Lys Ala Glu Glu Ile Arg Ile 
        35                  40                  45              


Lys Gly Lys Tyr Asn Ile Ser Ser Glu Asp Tyr Arg Gln Leu Glu Leu 
    50                  55                  60                  


Val Ile Leu Gln Ser Glu Pro His Arg Ala Gly Val Gln Trp Lys Phe 
65                  70                  75                  80  


Ala Gly Ser Phe Tyr Phe Ala Ile Thr Val Ile Thr Thr Ile Gly Tyr 
                85                  90                  95      


Gly His Ala Ala Pro Gly Thr Asp Ala Gly Lys Ala Phe Cys Met Phe 
            100                 105                 110         


Tyr Ala Val Leu Gly Ile Pro Leu Thr Leu Val Met Phe Gln Ser Leu 
        115                 120                 125             


Gly Glu Arg Met Asn Thr Phe Val Arg Tyr Leu Leu Lys Arg Ile Lys 
    130                 135                 140                 


Lys Cys Cys Gly Met Arg Asn Thr Asp Val Ser Met Glu Asn Met Val 
145                 150                 155                 160 


Thr Val Gly Phe Phe Ser Cys Met Gly Thr Leu Cys Ile Gly Ala Ala 
                165                 170                 175     


Ala Phe Ser Gln Cys Glu Glu Trp Ser Phe Phe His Ala Tyr Tyr Tyr 
            180                 185                 190         


Cys Phe Ile Thr Leu Thr Thr Ile Gly Phe Gly Asp Tyr Val Ala Leu 
        195                 200                 205             


Gln Thr Lys Gly Ala Leu Gln Lys Lys Pro Leu Tyr Val Ala Phe Ser 
    210                 215                 220                 


Phe Met Tyr Ile Leu Val Gly Leu Thr Val Ile Gly Ala Phe Leu Asn 
225                 230                 235                 240 


Leu Val Val Leu Arg Phe Leu Thr Met Asn Ser Glu Asp Glu Arg Arg 
                245                 250                 255     


Asp Ala Glu Glu Arg Ala Ser Leu Ala Gly Asn Arg Asn Ser Met Val 
            260                 265                 270         


Ile His Ile Pro Glu Glu Pro Arg Pro Ser Arg Pro Arg Tyr Lys Ala 
        275                 280                 285             


Asp Val Pro Asp Leu Gln Ser Val Cys Ser Cys Thr Cys Tyr Arg Ser 
    290                 295                 300                 


Gln Asp Tyr Gly Gly Arg Ser Val Ala Pro Gln Asn Ser Phe Ser Ala 
305                 310                 315                 320 


Lys Leu Ala Pro His Tyr Phe His Ser Ile Ser Tyr Lys Ile Glu Glu 
                325                 330                 335     


Ile Ser Pro Ser Thr Leu Lys Asn Ser Leu Phe Pro Ser Pro Ile Ser 
            340                 345                 350         


Ser Ile Ser Pro Gly Leu His Ser Phe Thr Asp His Gln Arg Leu Met 
        355                 360                 365             


Lys Arg Arg Lys Ser Val 
    370                 


<210>  20
<211>  1125
<212>  DNA
<213>  Homo sapiens

<400>  20
atgaagaggc agaacgtgcg gactctgtcc ctcatcgtct gcaccttcac ctacctgctg       60

gtgggcgccg ccgtgttcga cgccctcgag tcggaccacg agatgcgcga ggaggagaaa      120

ctcaaagccg aggagatccg gatcaagggg aagtacaaca tcagcagcga ggactaccgg      180

cagctggagc tggtgatcct gcagtcggaa ccgcaccgcg ccggcgtcca gtggaaattc      240

gccggctcct tctactttgc gatcacggtc atcaccacca taggttatgg gcacgctgca      300

cctggcaccg atgcgggcaa ggccttctgc atgttctacg ccgtgctggg catcccgctg      360

acactggtca tgttccagag cctgggcgag cgcatgaaca ccttcgtgcg ctacctgctg      420

aagcgcatta agaagtgctg tggcatgcgc aacactgacg tgtctatgga gaacatggtg      480

actgtgggct tcttctcctg catggggacg ctgtgcatcg gggcggccgc cttctcccag      540

tgtgaggagt ggagcttctt ccacgcctac tactactgct tcatcacgtt gactaccatt      600

gggttcgggg actacgtggc cctgcagacc aagggtgccc tgcagaagaa gccgctctac      660

gtggccttta gctttatgta tatcctggtg gggctgacgg tcatcggggc cttcctcaac      720

ctggtcgtcc tcaggttctt gaccatgaac agtgaggatg agcggcggga tgctgaagag      780

agggcatccc tcgccggaaa ccgcaacagc atggtcattc acatccctga ggagccgcgg      840

cccagccggc ccaggtacaa ggcggacgtc ccggacctgc agtctgtgtg ctcctgcacc      900

tgctaccgct cgcaggacta tggcggccgc tcggtggcac cgcagaactc cttcagcgcc      960

aagcttgccc cccactactt ccactccatc tcttacaaga tcgaggagat ctcaccaagc     1020

acattaaaaa acagcctctt cccatcgcct attagctcca tctctcctgg gttacacagc     1080

tttaccgacc accagaggct gatgaaacgc cggaagtccg tttag                     1125


<210>  21
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Phe Phe Leu Tyr Thr Asp Phe Phe Leu Ser Leu Val Ala Val Pro 
1               5                   10                  15      


Ala Ala Ala Pro Val Cys Gln Pro Lys Ser Ala Thr Asn Gly Gln Pro 
            20                  25                  30          


Pro Ala Pro Ala Pro Thr Pro Thr Pro Arg Leu Ser Ile Ser Ser Arg 
        35                  40                  45              


Ala Thr Val Val Ala Arg Met Glu Gly Thr Ser Gln Gly Gly Leu Gln 
    50                  55                  60                  


Thr Val Met Lys Trp Lys Thr Val Val Ala Ile Phe Val Val Val Val 
65                  70                  75                  80  


Val Tyr Leu Val Thr Gly Gly Leu Val Phe Arg Ala Leu Glu Gln Pro 
                85                  90                  95      


Phe Glu Ser Ser Gln Lys Asn Thr Ile Ala Leu Glu Lys Ala Glu Phe 
            100                 105                 110         


Leu Arg Asp His Val Cys Val Ser Pro Gln Glu Leu Glu Thr Leu Ile 
        115                 120                 125             


Gln His Ala Leu Asp Ala Asp Asn Ala Gly Val Ser Pro Ile Gly Asn 
    130                 135                 140                 


Ser Ser Asn Asn Ser Ser His Trp Asp Leu Gly Ser Ala Phe Phe Phe 
145                 150                 155                 160 


Ala Gly Thr Val Ile Thr Thr Ile Gly Tyr Gly Asn Ile Ala Pro Ser 
                165                 170                 175     


Thr Glu Gly Gly Lys Ile Phe Cys Ile Leu Tyr Ala Ile Phe Gly Ile 
            180                 185                 190         


Pro Leu Phe Gly Phe Leu Leu Ala Gly Ile Gly Asp Gln Leu Gly Thr 
        195                 200                 205             


Ile Phe Gly Lys Ser Ile Ala Arg Val Glu Lys Val Phe Arg Lys Lys 
    210                 215                 220                 


Gln Val Ser Gln Thr Lys Ile Arg Val Ile Ser Thr Ile Leu Phe Ile 
225                 230                 235                 240 


Leu Ala Gly Cys Ile Val Phe Val Thr Ile Pro Ala Val Ile Phe Lys 
                245                 250                 255     


Tyr Ile Glu Gly Trp Thr Ala Leu Glu Ser Ile Tyr Phe Val Val Val 
            260                 265                 270         


Thr Leu Thr Thr Val Gly Phe Gly Asp Phe Val Ala Gly Gly Asn Ala 
        275                 280                 285             


Gly Ile Asn Tyr Arg Glu Trp Tyr Lys Pro Leu Val Trp Phe Trp Ile 
    290                 295                 300                 


Leu Val Gly Leu Ala Tyr Phe Ala Ala Val Leu Ser Met Ile Gly Asp 
305                 310                 315                 320 


Trp Leu Arg Val Leu Ser Lys Lys Thr Lys Glu Glu Val Gly Glu Ile 
                325                 330                 335     


Lys Ala His Ala Ala Glu Trp Lys Ala Asn Val Thr Ala Glu Phe Arg 
            340                 345                 350         


Glu Thr Arg Arg Arg Leu Ser Val Glu Ile His Asp Lys Leu Gln Arg 
        355                 360                 365             


Ala Ala Thr Ile Arg Ser Met Glu Arg Arg Arg Leu Gly Leu Asp Gln 
    370                 375                 380                 


Arg Ala His Ser Leu Asp Met Leu Ser Pro Glu Lys Arg Ser Val Phe 
385                 390                 395                 400 


Ala Ala Leu Asp Thr Gly Arg Phe Lys Ala Ser Ser Gln Glu Ser Ile 
                405                 410                 415     


Asn Asn Arg Pro Asn Asn Leu Arg Leu Lys Gly Pro Glu Gln Leu Asn 
            420                 425                 430         


Lys His Gly Gln Gly Ala Ser Glu Asp Asn Ile Ile Asn Lys Phe Gly 
        435                 440                 445             


Ser Thr Ser Arg Leu Thr Lys Arg Lys Asn Lys Asp Leu Lys Lys Thr 
    450                 455                 460                 


Leu Pro Glu Asp Val Gln Lys Ile Tyr Lys Thr Phe Arg Asn Tyr Ser 
465                 470                 475                 480 


Leu Asp Glu Glu Lys Lys Glu Glu Glu Thr Glu Lys Met Cys Asn Ser 
                485                 490                 495     


Asp Asn Ser Ser Thr Ala Met Leu Thr Asp Cys Ile Gln Gln His Ala 
            500                 505                 510         


Glu Leu Glu Asn Gly Met Ile Pro Thr Asp Thr Lys Asp Arg Glu Pro 
        515                 520                 525             


Glu Asn Asn Ser Leu Leu Glu Asp Arg Asn 
    530                 535             


<210>  22
<211>  1617
<212>  DNA
<213>  Homo sapiens

<400>  22
atgttttttc tctacacaga cttctttctt tccttggtgg ccgttcccgc agcagcaccg       60

gtgtgccagc ccaagagcgc cactaacggg caacccccgg ctccggctcc gactccaact      120

ccgcgcctgt ccatttcctc ccgagccaca gtggtagcca ggatggaagg cacctcccaa      180

gggggcttgc agaccgtcat gaagtggaag acggtggttg ccatctttgt ggttgtggtg      240

gtctaccttg tcactggcgg tcttgtcttc cgggcattgg agcagccctt tgagagcagc      300

cagaagaata ccatcgcctt ggagaaggcg gaattcctgc gggatcatgt ctgtgtgagc      360

ccccaggagc tggagacgtt gatccagcat gctcttgatg ctgacaatgc gggagtcagt      420

ccaataggaa actcttccaa caacagcagc cactgggacc tcggcagtgc ctttttcttt      480

gctggaactg tcattacgac catagggtat gggaatattg ctccgagcac tgaaggaggc      540

aaaatctttt gtattttata tgccatcttt ggaattccac tctttggttt cttattggct      600

ggaattggag accaacttgg aaccatcttt gggaaaagca ttgcaagagt ggagaaggtc      660

tttcgaaaaa agcaagtgag tcagaccaag atccgggtca tctcaaccat cctgttcatc      720

ttggccggct gcattgtgtt tgtgacgatc cctgctgtca tctttaagta catcgagggc      780

tggacggcct tggagtccat ttactttgtg gtggtcactc tgaccacggt gggctttggt      840

gattttgtgg cagggggaaa cgctggcatc aattatcggg agtggtataa gcccctagtg      900

tggttttgga tccttgttgg ccttgcctac tttgcagctg tcctcagtat gatcggagat      960

tggctacggg ttctgtccaa aaagacaaaa gaagaggtgg gtgaaatcaa ggcccatgcg     1020

gcagagtgga aggccaatgt cacggctgag ttccgggaga cacggcgaag gctcagcgtg     1080

gagatccacg ataagctgca gcgggcggcc accatccgca gcatggagcg ccggcggctg     1140

ggcctggacc agcgggccca ctcactggac atgctgtccc ccgagaagcg ctctgtcttt     1200

gctgccctgg acaccggccg cttcaaggcc tcatcccagg agagcatcaa caaccggccc     1260

aacaacctgc gcctgaaggg gccggagcag ctgaacaagc atgggcaggg tgcgtccgag     1320

gacaacatca tcaacaagtt cgggtccacc tccagactca ccaagaggaa aaacaaggac     1380

ctcaaaaaga ccttgcccga ggacgttcag aaaatctaca agaccttccg gaattactcc     1440

ctggacgagg agaagaaaga ggaggagacg gaaaagatgt gtaactcaga caactccagc     1500

acagccatgc tgacggactg tatccagcag cacgctgagt tggagaacgg aatgataccc     1560

acggacacca aagaccggga gccggagaac aactcattac ttgaagacag aaactaa        1617


<210>  23
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Lys Phe Pro Ile Glu Thr Pro Arg Lys Gln Val Asn Trp Asp Pro 
1               5                   10                  15      


Lys Val Ala Val Pro Ala Ala Ala Pro Val Cys Gln Pro Lys Ser Ala 
            20                  25                  30          


Thr Asn Gly Gln Pro Pro Ala Pro Ala Pro Thr Pro Thr Pro Arg Leu 
        35                  40                  45              


Ser Ile Ser Ser Arg Ala Thr Val Val Ala Arg Met Glu Gly Thr Ser 
    50                  55                  60                  


Gln Gly Gly Leu Gln Thr Val Met Lys Trp Lys Thr Val Val Ala Ile 
65                  70                  75                  80  


Phe Val Val Val Val Val Tyr Leu Val Thr Gly Gly Leu Val Phe Arg 
                85                  90                  95      


Ala Leu Glu Gln Pro Phe Glu Ser Ser Gln Lys Asn Thr Ile Ala Leu 
            100                 105                 110         


Glu Lys Ala Glu Phe Leu Arg Asp His Val Cys Val Ser Pro Gln Glu 
        115                 120                 125             


Leu Glu Thr Leu Ile Gln His Ala Leu Asp Ala Asp Asn Ala Gly Val 
    130                 135                 140                 


Ser Pro Ile Gly Asn Ser Ser Asn Asn Ser Ser His Trp Asp Leu Gly 
145                 150                 155                 160 


Ser Ala Phe Phe Phe Ala Gly Thr Val Ile Thr Thr Ile Gly Tyr Gly 
                165                 170                 175     


Asn Ile Ala Pro Ser Thr Glu Gly Gly Lys Ile Phe Cys Ile Leu Tyr 
            180                 185                 190         


Ala Ile Phe Gly Ile Pro Leu Phe Gly Phe Leu Leu Ala Gly Ile Gly 
        195                 200                 205             


Asp Gln Leu Gly Thr Ile Phe Gly Lys Ser Ile Ala Arg Val Glu Lys 
    210                 215                 220                 


Val Phe Arg Lys Lys Gln Val Ser Gln Thr Lys Ile Arg Val Ile Ser 
225                 230                 235                 240 


Thr Ile Leu Phe Ile Leu Ala Gly Cys Ile Val Phe Val Thr Ile Pro 
                245                 250                 255     


Ala Val Ile Phe Lys Tyr Ile Glu Gly Trp Thr Ala Leu Glu Ser Ile 
            260                 265                 270         


Tyr Phe Val Val Val Thr Leu Thr Thr Val Gly Phe Gly Asp Phe Val 
        275                 280                 285             


Ala Gly Gly Asn Ala Gly Ile Asn Tyr Arg Glu Trp Tyr Lys Pro Leu 
    290                 295                 300                 


Val Trp Phe Trp Ile Leu Val Gly Leu Ala Tyr Phe Ala Ala Val Leu 
305                 310                 315                 320 


Ser Met Ile Gly Asp Trp Leu Arg Val Leu Ser Lys Lys Thr Lys Glu 
                325                 330                 335     


Glu Val Gly Glu Ile Lys Ala His Ala Ala Glu Trp Lys Ala Asn Val 
            340                 345                 350         


Thr Ala Glu Phe Arg Glu Thr Arg Arg Arg Leu Ser Val Glu Ile His 
        355                 360                 365             


Asp Lys Leu Gln Arg Ala Ala Thr Ile Arg Ser Met Glu Arg Arg Arg 
    370                 375                 380                 


Leu Gly Leu Asp Gln Arg Ala His Ser Leu Asp Met Leu Ser Pro Glu 
385                 390                 395                 400 


Lys Arg Ser Val Phe Ala Ala Leu Asp Thr Gly Arg Phe Lys Ala Ser 
                405                 410                 415     


Ser Gln Glu Ser Ile Asn Asn Arg Pro Asn Asn Leu Arg Leu Lys Gly 
            420                 425                 430         


Pro Glu Gln Leu Asn Lys His Gly Gln Gly Ala Ser Glu Asp Asn Ile 
        435                 440                 445             


Ile Asn Lys Phe Gly Ser Thr Ser Arg Leu Thr Lys Arg Lys Asn Lys 
    450                 455                 460                 


Asp Leu Lys Lys Thr Leu Pro Glu Asp Val Gln Lys Ile Tyr Lys Thr 
465                 470                 475                 480 


Phe Arg Asn Tyr Ser Leu Asp Glu Glu Lys Lys Glu Glu Glu Thr Glu 
                485                 490                 495     


Lys Met Cys Asn Ser Asp Asn Ser Ser Thr Ala Met Leu Thr Asp Cys 
            500                 505                 510         


Ile Gln Gln His Ala Glu Leu Glu Asn Gly Met Ile Pro Thr Asp Thr 
        515                 520                 525             


Lys Asp Arg Glu Pro Glu Asn Asn Ser Leu Leu Glu Asp Arg Asn 
    530                 535                 540             


<210>  24
<211>  1632
<212>  DNA
<213>  Homo sapiens

<400>  24
atgaaatttc caatcgagac gccaagaaaa caggtgaact gggatcctaa agtggccgtt       60

cccgcagcag caccggtgtg ccagcccaag agcgccacta acgggcaacc cccggctccg      120

gctccgactc caactccgcg cctgtccatt tcctcccgag ccacagtggt agccaggatg      180

gaaggcacct cccaaggggg cttgcagacc gtcatgaagt ggaagacggt ggttgccatc      240

tttgtggttg tggtggtcta ccttgtcact ggcggtcttg tcttccgggc attggagcag      300

ccctttgaga gcagccagaa gaataccatc gccttggaga aggcggaatt cctgcgggat      360

catgtctgtg tgagccccca ggagctggag acgttgatcc agcatgctct tgatgctgac      420

aatgcgggag tcagtccaat aggaaactct tccaacaaca gcagccactg ggacctcggc      480

agtgcctttt tctttgctgg aactgtcatt acgaccatag ggtatgggaa tattgctccg      540

agcactgaag gaggcaaaat cttttgtatt ttatatgcca tctttggaat tccactcttt      600

ggtttcttat tggctggaat tggagaccaa cttggaacca tctttgggaa aagcattgca      660

agagtggaga aggtctttcg aaaaaagcaa gtgagtcaga ccaagatccg ggtcatctca      720

accatcctgt tcatcttggc cggctgcatt gtgtttgtga cgatccctgc tgtcatcttt      780

aagtacatcg agggctggac ggccttggag tccatttact ttgtggtggt cactctgacc      840

acggtgggct ttggtgattt tgtggcaggg ggaaacgctg gcatcaatta tcgggagtgg      900

tataagcccc tagtgtggtt ttggatcctt gttggccttg cctactttgc agctgtcctc      960

agtatgatcg gagattggct acgggttctg tccaaaaaga caaaagaaga ggtgggtgaa     1020

atcaaggccc atgcggcaga gtggaaggcc aatgtcacgg ctgagttccg ggagacacgg     1080

cgaaggctca gcgtggagat ccacgataag ctgcagcggg cggccaccat ccgcagcatg     1140

gagcgccggc ggctgggcct ggaccagcgg gcccactcac tggacatgct gtcccccgag     1200

aagcgctctg tctttgctgc cctggacacc ggccgcttca aggcctcatc ccaggagagc     1260

atcaacaacc ggcccaacaa cctgcgcctg aaggggccgg agcagctgaa caagcatggg     1320

cagggtgcgt ccgaggacaa catcatcaac aagttcgggt ccacctccag actcaccaag     1380

aggaaaaaca aggacctcaa aaagaccttg cccgaggacg ttcagaaaat ctacaagacc     1440

ttccggaatt actccctgga cgaggagaag aaagaggagg agacggaaaa gatgtgtaac     1500

tcagacaact ccagcacagc catgctgacg gactgtatcc agcagcacgc tgagttggag     1560

aacggaatga tacccacgga caccaaagac cgggagccgg agaacaactc attacttgaa     1620

gacagaaact aa                                                         1632


<210>  25
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Glu Asp Gly Phe Lys Gly Asp Arg Thr Glu Gly Cys Arg Ser Asp 
1               5                   10                  15      


Ser Val Ala Val Pro Ala Ala Ala Pro Val Cys Gln Pro Lys Ser Ala 
            20                  25                  30          


Thr Asn Gly Gln Pro Pro Ala Pro Ala Pro Thr Pro Thr Pro Arg Leu 
        35                  40                  45              


Ser Ile Ser Ser Arg Ala Thr Val Val Ala Arg Met Glu Gly Thr Ser 
    50                  55                  60                  


Gln Gly Gly Leu Gln Thr Val Met Lys Trp Lys Thr Val Val Ala Ile 
65                  70                  75                  80  


Phe Val Val Val Val Val Tyr Leu Val Thr Gly Gly Leu Val Phe Arg 
                85                  90                  95      


Ala Leu Glu Gln Pro Phe Glu Ser Ser Gln Lys Asn Thr Ile Ala Leu 
            100                 105                 110         


Glu Lys Ala Glu Phe Leu Arg Asp His Val Cys Val Ser Pro Gln Glu 
        115                 120                 125             


Leu Glu Thr Leu Ile Gln His Ala Leu Asp Ala Asp Asn Ala Gly Val 
    130                 135                 140                 


Ser Pro Ile Gly Asn Ser Ser Asn Asn Ser Ser His Trp Asp Leu Gly 
145                 150                 155                 160 


Ser Ala Phe Phe Phe Ala Gly Thr Val Ile Thr Thr Ile Gly Tyr Gly 
                165                 170                 175     


Asn Ile Ala Pro Ser Thr Glu Gly Gly Lys Ile Phe Cys Ile Leu Tyr 
            180                 185                 190         


Ala Ile Phe Gly Ile Pro Leu Phe Gly Phe Leu Leu Ala Gly Ile Gly 
        195                 200                 205             


Asp Gln Leu Gly Thr Ile Phe Gly Lys Ser Ile Ala Arg Val Glu Lys 
    210                 215                 220                 


Val Phe Arg Lys Lys Gln Val Ser Gln Thr Lys Ile Arg Val Ile Ser 
225                 230                 235                 240 


Thr Ile Leu Phe Ile Leu Ala Gly Cys Ile Val Phe Val Thr Ile Pro 
                245                 250                 255     


Ala Val Ile Phe Lys Tyr Ile Glu Gly Trp Thr Ala Leu Glu Ser Ile 
            260                 265                 270         


Tyr Phe Val Val Val Thr Leu Thr Thr Val Gly Phe Gly Asp Phe Val 
        275                 280                 285             


Ala Gly Gly Asn Ala Gly Ile Asn Tyr Arg Glu Trp Tyr Lys Pro Leu 
    290                 295                 300                 


Val Trp Phe Trp Ile Leu Val Gly Leu Ala Tyr Phe Ala Ala Val Leu 
305                 310                 315                 320 


Ser Met Ile Gly Asp Trp Leu Arg Val Leu Ser Lys Lys Thr Lys Glu 
                325                 330                 335     


Glu Val Gly Glu Ile Lys Ala His Ala Ala Glu Trp Lys Ala Asn Val 
            340                 345                 350         


Thr Ala Glu Phe Arg Glu Thr Arg Arg Arg Leu Ser Val Glu Ile His 
        355                 360                 365             


Asp Lys Leu Gln Arg Ala Ala Thr Ile Arg Ser Met Glu Arg Arg Arg 
    370                 375                 380                 


Leu Gly Leu Asp Gln Arg Ala His Ser Leu Asp Met Leu Ser Pro Glu 
385                 390                 395                 400 


Lys Arg Ser Val Phe Ala Ala Leu Asp Thr Gly Arg Phe Lys Ala Ser 
                405                 410                 415     


Ser Gln Glu Ser Ile Asn Asn Arg Pro Asn Asn Leu Arg Leu Lys Gly 
            420                 425                 430         


Pro Glu Gln Leu Asn Lys His Gly Gln Gly Ala Ser Glu Asp Asn Ile 
        435                 440                 445             


Ile Asn Lys Phe Gly Ser Thr Ser Arg Leu Thr Lys Arg Lys Asn Lys 
    450                 455                 460                 


Asp Leu Lys Lys Thr Leu Pro Glu Asp Val Gln Lys Ile Tyr Lys Thr 
465                 470                 475                 480 


Phe Arg Asn Tyr Ser Leu Asp Glu Glu Lys Lys Glu Glu Glu Thr Glu 
                485                 490                 495     


Lys Met Cys Asn Ser Asp Asn Ser Ser Thr Ala Met Leu Thr Asp Cys 
            500                 505                 510         


Ile Gln Gln His Ala Glu Leu Glu Asn Gly Met Ile Pro Thr Asp Thr 
        515                 520                 525             


Lys Asp Arg Glu Pro Glu Asn Asn Ser Leu Leu Glu Asp Arg Asn 
    530                 535                 540             


<210>  26
<211>  1632
<212>  DNA
<213>  Homo sapiens

<400>  26
atggaggatg gatttaaggg ggacaggact gaaggctgtc gcagtgattc agtggccgtt       60

cccgcagcag caccggtgtg ccagcccaag agcgccacta acgggcaacc cccggctccg      120

gctccgactc caactccgcg cctgtccatt tcctcccgag ccacagtggt agccaggatg      180

gaaggcacct cccaaggggg cttgcagacc gtcatgaagt ggaagacggt ggttgccatc      240

tttgtggttg tggtggtcta ccttgtcact ggcggtcttg tcttccgggc attggagcag      300

ccctttgaga gcagccagaa gaataccatc gccttggaga aggcggaatt cctgcgggat      360

catgtctgtg tgagccccca ggagctggag acgttgatcc agcatgctct tgatgctgac      420

aatgcgggag tcagtccaat aggaaactct tccaacaaca gcagccactg ggacctcggc      480

agtgcctttt tctttgctgg aactgtcatt acgaccatag ggtatgggaa tattgctccg      540

agcactgaag gaggcaaaat cttttgtatt ttatatgcca tctttggaat tccactcttt      600

ggtttcttat tggctggaat tggagaccaa cttggaacca tctttgggaa aagcattgca      660

agagtggaga aggtctttcg aaaaaagcaa gtgagtcaga ccaagatccg ggtcatctca      720

accatcctgt tcatcttggc cggctgcatt gtgtttgtga cgatccctgc tgtcatcttt      780

aagtacatcg agggctggac ggccttggag tccatttact ttgtggtggt cactctgacc      840

acggtgggct ttggtgattt tgtggcaggg ggaaacgctg gcatcaatta tcgggagtgg      900

tataagcccc tagtgtggtt ttggatcctt gttggccttg cctactttgc agctgtcctc      960

agtatgatcg gagattggct acgggttctg tccaaaaaga caaaagaaga ggtgggtgaa     1020

atcaaggccc atgcggcaga gtggaaggcc aatgtcacgg ctgagttccg ggagacacgg     1080

cgaaggctca gcgtggagat ccacgataag ctgcagcggg cggccaccat ccgcagcatg     1140

gagcgccggc ggctgggcct ggaccagcgg gcccactcac tggacatgct gtcccccgag     1200

aagcgctctg tctttgctgc cctggacacc ggccgcttca aggcctcatc ccaggagagc     1260

atcaacaacc ggcccaacaa cctgcgcctg aaggggccgg agcagctgaa caagcatggg     1320

cagggtgcgt ccgaggacaa catcatcaac aagttcgggt ccacctccag actcaccaag     1380

aggaaaaaca aggacctcaa aaagaccttg cccgaggacg ttcagaaaat ctacaagacc     1440

ttccggaatt actccctgga cgaggagaag aaagaggagg agacggaaaa gatgtgtaac     1500

tcagacaact ccagcacagc catgctgacg gactgtatcc agcagcacgc tgagttggag     1560

aacggaatga tacccacgga caccaaagac cgggagccgg agaacaactc attacttgaa     1620

gacagaaact aa                                                         1632


<210>  27
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ser Ser Arg Ser Pro Arg Pro Pro Pro Arg Arg Ser Arg Arg Arg 
1               5                   10                  15      


Leu Pro Arg Pro Ser Cys Cys Cys Cys Cys Cys Arg Arg Ser His Leu 
            20                  25                  30          


Asn Glu Asp Thr Gly Arg Phe Val Leu Leu Ala Ala Leu Ile Gly Leu 
        35                  40                  45              


Tyr Leu Val Ala Gly Ala Thr Val Phe Ser Ala Leu Glu Ser Pro Gly 
    50                  55                  60                  


Glu Ala Glu Ala Arg Ala Arg Trp Gly Ala Thr Leu Arg Asn Phe Ser 
65                  70                  75                  80  


Ala Ala His Gly Val Ala Glu Pro Glu Leu Arg Ala Phe Leu Arg His 
                85                  90                  95      


Tyr Glu Ala Ala Leu Ala Ala Gly Val Arg Ala Asp Ala Leu Arg Pro 
            100                 105                 110         


Arg Trp Asp Phe Pro Gly Ala Phe Tyr Phe Val Gly Thr Val Val Ser 
        115                 120                 125             


Thr Ile Gly Phe Gly Met Thr Thr Pro Ala Thr Val Gly Gly Lys Ala 
    130                 135                 140                 


Phe Leu Ile Ala Tyr Gly Leu Phe Gly Cys Ala Gly Thr Ile Leu Phe 
145                 150                 155                 160 


Phe Asn Leu Phe Leu Glu Arg Ile Ile Ser Leu Leu Ala Phe Ile Met 
                165                 170                 175     


Arg Ala Cys Arg Glu Arg Gln Leu Arg Arg Ser Gly Leu Leu Pro Ala 
            180                 185                 190         


Thr Phe Arg Arg Gly Ser Ala Leu Ser Glu Ala Asp Ser Leu Ala Gly 
        195                 200                 205             


Trp Lys Pro Ser Val Tyr His Val Leu Leu Ile Leu Gly Leu Phe Ala 
    210                 215                 220                 


Val Leu Leu Ser Cys Cys Ala Ser Ala Met Tyr Thr Ser Val Glu Gly 
225                 230                 235                 240 


Trp Asp Tyr Val Asp Ser Leu Tyr Phe Cys Phe Val Thr Phe Ser Thr 
                245                 250                 255     


Ile Gly Phe Gly Asp Leu Val Ser Ser Gln His Ala Ala Tyr Arg Asn 
            260                 265                 270         


Gln Gly Leu Tyr Arg Leu Gly Asn Phe Leu Phe Ile Leu Leu Gly Val 
        275                 280                 285             


Cys Cys Ile Tyr Ser Leu Phe Asn Val Ile Ser Ile Leu Ile Lys Gln 
    290                 295                 300                 


Val Leu Asn Trp Met Leu Arg Lys Leu Ser Cys Arg Cys Cys Ala Arg 
305                 310                 315                 320 


Cys Cys Pro Ala Pro Gly Ala Pro Leu Ala Arg Arg Asn Ala Ile Thr 
                325                 330                 335     


Pro Gly Ser Arg Leu Arg Arg Arg Leu Ala Ala Leu Gly Ala Asp Pro 
            340                 345                 350         


Ala Ala Arg Asp Ser Asp Ala Glu Gly Arg Arg Leu Ser Gly Glu Leu 
        355                 360                 365             


Ile Ser Met Arg Asp Leu Thr Ala Ser Asn Lys Val Ser Leu Ala Leu 
    370                 375                 380                 


Leu Gln Lys Gln Leu Ser Glu Thr Ala Asn Gly Tyr Pro Arg Ser Val 
385                 390                 395                 400 


Cys Val Asn Thr Arg Gln Asn Gly Phe Ser Gly Gly Val Gly Ala Leu 
                405                 410                 415     


Gly Ile Met Asn Asn Arg Leu Ala Glu Thr Ser Ala Ser Arg 
            420                 425                 430 


<210>  28
<211>  1293
<212>  DNA
<213>  Homo sapiens

<400>  28
atgtcctccc gcagcccccg gcccccgccc cgccgtagcc gccgccgcct gccgcgcccc       60

tcctgctgct gctgctgctg ccgccgttcg cacctcaacg aggacaccgg ccgcttcgtg      120

ctgctggcgg cgctcatcgg cctctacctg gtggcgggtg ccacagtctt ctcggcgctc      180

gagagccccg gcgaggcgga ggcgcgggcg cgctggggcg ccacgctgcg caacttcagc      240

gctgcgcacg gcgtggccga gccagagctg cgcgccttcc tccggcacta cgaggccgcg      300

ctggccgccg gcgtccgcgc cgacgcgctg cgcccgcgct gggacttccc cggcgccttc      360

tacttcgtgg gcaccgtggt gtcaaccata ggtttcggca tgaccacccc cgcgacggtg      420

ggcgggaagg ccttcctcat cgcctacggg ctgttcggct gcgctgggac catcctgttc      480

ttcaacctct tcctggagcg catcatctcg ctgctggcct tcatcatgcg cgcctgccgg      540

gagcgccagc tgcgccgcag cggcctgctg cccgccacct tccgccgcgg ctccgcgctc      600

tcggaggccg acagcctggc gggctggaag ccctcggtgt accacgtgct gctcatcctg      660

ggcctgttcg ccgtgctgct gtcctgctgc gcctcggcca tgtacaccag cgtggagggc      720

tgggactacg tggactcgct ctacttctgc ttcgtcacct tcagcaccat cggcttcggg      780

gacctggtga gcagccagca cgccgcctac cggaaccagg ggctctaccg cctgggcaac      840

ttcctcttca tcctgctcgg cgtgtgctgc atttactcgc tcttcaacgt catctccatc      900

ctcatcaagc aggtgctcaa ctggatgctg cgcaagctga gctgccgctg ctgcgcgcgc      960

tgctgcccgg ctcctggcgc gcccctggcc cggcgcaatg ccatcacccc aggctcccgg     1020

ctgcgccgcc gcctggccgc gctcggtgcc gaccccgcgg cccgcgacag cgacgccgag     1080

ggccgccgcc tctcgggcga gctcatctcc atgcgcgacc tcacggcctc caacaaggtg     1140

tcgctggcgc tgctgcagaa gcagctgtcg gagacggcca acggctaccc gcgcagcgtg     1200

tgcgtcaaca cgcgccagaa cggcttctcg ggcggcgtgg gcgcgctggg catcatgaac     1260

aaccggctgg ccgagaccag cgcctccagg tag                                  1293


<210>  29
<211>  408
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ala Gly Arg Gly Phe Ser Trp Gly Pro Gly His Leu Asn Glu Asp 
1               5                   10                  15      


Asn Ala Arg Phe Leu Leu Leu Ala Ala Leu Ile Val Leu Tyr Leu Leu 
            20                  25                  30          


Gly Gly Ala Ala Val Phe Ser Ala Leu Glu Leu Ala His Glu Arg Gln 
        35                  40                  45              


Ala Lys Gln Arg Trp Glu Glu Arg Leu Ala Asn Phe Ser Arg Gly His 
    50                  55                  60                  


Asn Leu Ser Arg Asp Glu Leu Arg Gly Phe Leu Arg His Tyr Glu Glu 
65                  70                  75                  80  


Ala Thr Arg Ala Gly Ile Arg Val Asp Asn Val Arg Pro Arg Trp Asp 
                85                  90                  95      


Phe Thr Gly Ala Phe Tyr Phe Val Gly Thr Val Val Ser Thr Ile Gly 
            100                 105                 110         


Phe Gly Met Thr Thr Pro Ala Thr Val Gly Gly Lys Ile Phe Leu Ile 
        115                 120                 125             


Phe Tyr Gly Leu Val Gly Cys Ser Ser Thr Ile Leu Phe Phe Asn Leu 
    130                 135                 140                 


Phe Leu Glu Arg Leu Ile Thr Ile Ile Ala Tyr Ile Met Lys Ser Cys 
145                 150                 155                 160 


His Gln Arg Gln Leu Arg Arg Arg Gly Ala Leu Pro Gln Glu Ser Leu 
                165                 170                 175     


Lys Asp Ala Gly Gln Cys Glu Val Asp Ser Leu Ala Gly Trp Lys Pro 
            180                 185                 190         


Ser Val Tyr Tyr Val Met Leu Ile Leu Cys Thr Ala Ser Ile Leu Ile 
        195                 200                 205             


Ser Cys Cys Ala Ser Ala Met Tyr Thr Pro Ile Glu Gly Trp Ser Tyr 
    210                 215                 220                 


Phe Asp Ser Leu Tyr Phe Cys Phe Val Ala Phe Ser Thr Ile Gly Phe 
225                 230                 235                 240 


Gly Asp Leu Val Ser Ser Gln Asn Ala His Tyr Glu Ser Gln Gly Leu 
                245                 250                 255     


Tyr Arg Phe Ala Asn Phe Val Phe Ile Leu Met Gly Val Cys Cys Ile 
            260                 265                 270         


Tyr Ser Leu Phe Asn Val Ile Ser Ile Leu Ile Lys Gln Ser Leu Asn 
        275                 280                 285             


Trp Ile Leu Arg Lys Met Asp Ser Gly Cys Cys Pro Gln Cys Gln Arg 
    290                 295                 300                 


Gly Leu Leu Arg Ser Arg Arg Asn Val Val Met Pro Gly Ser Val Arg 
305                 310                 315                 320 


Asn Arg Cys Asn Ile Ser Ile Glu Thr Asp Gly Val Ala Glu Ser Asp 
                325                 330                 335     


Thr Asp Gly Arg Arg Leu Ser Gly Glu Met Ile Ser Met Lys Asp Leu 
            340                 345                 350         


Leu Ala Ala Asn Lys Ala Ser Leu Ala Ile Leu Gln Lys Gln Leu Ser 
        355                 360                 365             


Glu Met Ala Asn Gly Cys Pro His Gln Thr Ser Thr Leu Ala Arg Asp 
    370                 375                 380                 


Asn Glu Phe Ser Gly Gly Val Gly Ala Phe Ala Ile Met Asn Asn Arg 
385                 390                 395                 400 


Leu Ala Glu Thr Ser Gly Asp Arg 
                405             


<210>  30
<211>  1227
<212>  DNA
<213>  Homo sapiens

<400>  30
atggctggcc ggggtttcag ctggggcccg ggccacctga acgaggacaa cgcgcgcttt       60

ctgctgctgg ccgcgctcat cgtgctctac ctgctgggcg gcgccgccgt cttctccgcg      120

ctggagctgg cgcacgagcg ccaggccaag cagcgctggg aggagcgcct ggccaacttc      180

agccgcggcc acaacctgag ccgcgacgag ctgcgcggct tcctccgcca ctacgaggag      240

gccactcggg ccggcatccg cgtggacaac gtccgcccgc gctgggactt caccggcgcc      300

ttctacttcg tgggcaccgt cgtttccacc atagggtttg ggatgacaac tccggcgaca      360

gtaggaggaa aaatctttct gatcttttac ggccttgttg ggtgttccag caccatcttg      420

ttcttcaacc tcttcctgga gcgcctgatc accatcatcg cctacatcat gaagtcgtgc      480

caccagcggc agctccggag acgaggggcc ctgccccagg agagcctgaa ggatgcgggg      540

cagtgtgagg tggacagcct ggccggctgg aagccctccg tgtactacgt catgctgatc      600

ctatgcacag cctccatcct catctcttgc tgcgcctcag ccatgtacac ccccattgaa      660

ggctggagct actttgactc actctacttc tgttttgtgg ctttcagcac cattggcttt      720

ggggacctgg tcagcagcca gaacgcccac tatgagagcc aaggcctcta tcgctttgcc      780

aacttcgtct tcatcctcat gggtgtctgc tgcatctact ccttgttcaa tgtcatctct      840

atcctcatca aacagtcctt gaactggatc ctgaggaaaa tggacagcgg gtgctgcccg      900

caatgccaga gaggactctt gcgatcacgc aggaacgtgg tgatgccagg cagcgtccgg      960

aaccgctgca acatctccat agagacagac ggggtggcag agagtgacac ggacgggcgc     1020

cggctctcag gggagatgat ctccatgaag gacttgctgg cagccaacaa ggcctcgttg     1080

gccatcctgc agaagcaact gtctgagatg gccaacggct gcccccacca gaccagcaca     1140

ctggcccggg acaatgaatt ctcagggggg gtgggagcct ttgcaatcat gaacaacagg     1200

ttggcagaga ccagtgggga caggtag                                         1227


<210>  31
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Arg Arg Pro Ser Val Arg Ala Ala Gly Leu Val Leu Cys Thr Leu 
1               5                   10                  15      


Cys Tyr Leu Leu Val Gly Ala Ala Val Phe Asp Ala Leu Glu Ser Glu 
            20                  25                  30          


Ala Glu Ser Gly Arg Gln Arg Leu Leu Val Gln Lys Arg Gly Ala Leu 
        35                  40                  45              


Arg Arg Lys Phe Gly Phe Ser Ala Glu Asp Tyr Arg Glu Leu Glu Arg 
    50                  55                  60                  


Leu Ala Leu Gln Ala Glu Pro His Arg Ala Gly Arg Gln Trp Lys Phe 
65                  70                  75                  80  


Pro Gly Ser Phe Tyr Phe Ala Ile Thr Val Ile Thr Thr Ile Glu Tyr 
                85                  90                  95      


Gly His Ala Ala Pro Gly Thr Asp Ser Gly Lys Val Phe Cys Met Phe 
            100                 105                 110         


Tyr Ala Leu Leu Gly Ile Pro Leu Thr Leu Val Thr Phe Gln Ser Leu 
        115                 120                 125             


Gly Glu Arg Leu Asn Ala Val Val Arg Arg Leu Leu Leu Ala Ala Lys 
    130                 135                 140                 


Cys Cys Leu Gly Leu Arg Trp Thr Cys Val Ser Thr Glu Asn Leu Val 
145                 150                 155                 160 


Val Ala Gly Leu Leu Ala Cys Ala Ala Thr Leu Ala Leu Gly Ala Val 
                165                 170                 175     


Ala Phe Ser His Phe Glu Gly Trp Thr Phe Phe His Ala Tyr Tyr Tyr 
            180                 185                 190         


Cys Phe Ile Thr Leu Thr Thr Ile Gly Phe Gly Asp Phe Val Ala Leu 
        195                 200                 205             


Gln Ser Gly Glu Ala Leu Gln Arg Lys Leu Pro Tyr Val Ala Phe Ser 
    210                 215                 220                 


Phe Leu Tyr Ile Leu Leu Gly Leu Thr Val Ile Gly Ala Phe Leu Asn 
225                 230                 235                 240 


Leu Val Val Leu Arg Phe Leu Val Ala Ser Ala Asp Trp Pro Glu Arg 
                245                 250                 255     


Ala Ala Arg Thr Pro Ser Pro Arg Pro Pro Gly Ala Pro Glu Ser Arg 
            260                 265                 270         


Gly Leu Trp Leu Pro Arg Arg Pro Ala Arg Ser Val Gly Ser Ala Ser 
        275                 280                 285             


Val Phe Cys His Val His Lys Leu Glu Arg Cys Ala Arg Asp Asn Leu 
    290                 295                 300                 


Gly Phe Ser Pro Pro Ser Ser Pro Gly Val Val Arg Gly Gly Gln Ala 
305                 310                 315                 320 


Pro Arg Leu Gly Ala Arg Trp Lys Ser Ile 
                325                 330 


<210>  32
<211>  993
<212>  DNA
<213>  Homo sapiens

<400>  32
atgcggaggc cgagcgtgcg cgcggccggg ctggtcctgt gcaccctgtg ttacctgctg       60

gtgggcgctg ctgtcttcga cgcgctcgag tccgaggcgg aaagcggccg ccagcgactg      120

ctggtccaga agcggggcgc tctccggagg aagttcggct tctcggccga ggactaccgc      180

gagctggagc gcctggcgct ccaggctgag ccccaccgcg ccggccgcca gtggaagttc      240

cccggctcct tctacttcgc catcaccgtc atcactacca tcgagtacgg ccacgccgcg      300

ccgggtacgg actccggcaa ggtcttctgc atgttctacg cgctcctggg catcccgctg      360

acgctggtca ctttccagag cctgggcgaa cggctgaacg cggtggtgcg gcgcctcctg      420

ttggcggcca agtgctgcct gggcctgcgg tggacgtgcg tgtccacgga gaacctggtg      480

gtggccgggc tgctggcgtg tgccgccacc ctggccctcg gggccgtcgc cttctcgcac      540

ttcgagggct ggaccttctt ccacgcctac tactactgct tcatcaccct caccaccatc      600

ggcttcggcg acttcgtggc actgcagagc ggcgaggcgc tgcagaggaa gctcccctac      660

gtggccttca gcttcctcta catcctcctg gggctcacgg tcattggcgc cttcctcaac      720

ctggtggtcc tgcgcttcct cgttgccagc gccgactggc ccgagcgcgc tgcccgcacc      780

cccagcccgc gccccccggg ggcgcccgag agccgtggcc tctggctgcc ccgccgcccg      840

gcccgctccg tgggctccgc ctctgtcttc tgccacgtgc acaagctgga gaggtgcgcc      900

cgcgacaacc tgggcttttc gcccccctcg agcccggggg tcgtgcgtgg cgggcaggct      960

cccaggcttg gggcccggtg gaagtccatc tga                                   993


<210>  33
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Pro Ser Ala Gly Leu Cys Ser Cys Trp Gly Gly Arg Val Leu Pro 
1               5                   10                  15      


Leu Leu Leu Ala Tyr Val Cys Tyr Leu Leu Leu Gly Ala Thr Ile Phe 
            20                  25                  30          


Gln Leu Leu Glu Arg Gln Ala Glu Ala Gln Ser Arg Asp Gln Phe Gln 
        35                  40                  45              


Leu Glu Lys Leu Arg Phe Leu Glu Asn Tyr Thr Cys Leu Asp Gln Trp 
    50                  55                  60                  


Ala Met Glu Gln Phe Val Gln Val Ile Met Glu Ala Trp Val Lys Gly 
65                  70                  75                  80  


Val Asn Pro Lys Gly Asn Ser Thr Asn Pro Ser Asn Trp Asp Phe Gly 
                85                  90                  95      


Ser Ser Phe Phe Phe Ala Gly Thr Val Val Thr Thr Ile Gly Tyr Gly 
            100                 105                 110         


Asn Leu Ala Pro Ser Thr Glu Ala Gly Gln Val Phe Cys Val Phe Tyr 
        115                 120                 125             


Ala Leu Leu Gly Ile Pro Leu Asn Val Ile Phe Leu Asn His Leu Gly 
    130                 135                 140                 


Thr Gly Leu Arg Ala His Leu Ala Ala Ile Glu Arg Trp Glu Asp Arg 
145                 150                 155                 160 


Pro Arg Arg Ser Gln Val Leu Gln Val Leu Gly Leu Ala Leu Phe Leu 
                165                 170                 175     


Thr Leu Gly Thr Leu Val Ile Leu Ile Phe Pro Pro Met Val Phe Ser 
            180                 185                 190         


His Val Glu Gly Trp Ser Phe Ser Glu Gly Phe Tyr Phe Ala Phe Ile 
        195                 200                 205             


Thr Leu Ser Thr Ile Gly Phe Gly Asp Tyr Val Val Gly Thr Asp Pro 
    210                 215                 220                 


Ser Lys His Tyr Ile Ser Val Tyr Arg Ser Leu Ala Ala Ile Trp Ile 
225                 230                 235                 240 


Leu Leu Gly Leu Ala Trp Leu Ala Leu Ile Leu Pro Leu Gly Pro Leu 
                245                 250                 255     


Leu Leu His Arg Cys Cys Gln Leu Trp Leu Leu Ser Arg Gly Leu Gly 
            260                 265                 270         


Val Lys Asp Gly Ala Ala Ser Asp Pro Ser Gly Leu Pro Arg Pro Gln 
        275                 280                 285             


Lys Ile Pro Ile Ser Ala 
    290                 


<210>  34
<211>  885
<212>  DNA
<213>  Homo sapiens

<400>  34
atgcccagtg ctgggctctg cagctgctgg ggtggccggg tgctgcccct gctgctggcc       60

tatgtctgct acctgctgct cggtgccact atcttccagc tgctagagag gcaggcagag      120

gctcagtcca gggaccagtt tcagttggag aagctgcgct tcctggagaa ctacacctgc      180

ctggaccagt gggccatgga gcagtttgtg caggtcatca tggaagcctg ggtgaaaggt      240

gtgaacccca aaggcaactc taccaacccc agcaactggg actttggcag cagtttcttc      300

tttgcaggca cagtcgtcac taccatagga tatgggaacc tggcacccag cacagaggca      360

ggtcaggtct tctgtgtctt ctatgccctg ttgggcatcc cgcttaacgt gatcttcctc      420

aaccacctgg gcacagggct gcgtgcccat ctggccgcca ttgaaagatg ggaggaccgt      480

cccaggcgct cccaggtact gcaagtcctg ggcctggctc tgttcctgac cctggggacg      540

ctggtcattc tcatcttccc acccatggtc ttcagccatg tggagggctg gagcttcagc      600

gagggcttct actttgcttt catcactctc agcaccattg gctttgggga ctatgttgtt      660

ggcacagacc ccagcaagca ttatatctca gtgtaccgga gcctggcagc catctggatc      720

ctcctgggcc tggcgtggct ggcgctgatc ctcccactgg gccccctgct tctgcacaga      780

tgctgccagc tctggctgct cagtaggggc ctcggcgtca aggatggggc agcctctgac      840

cccagtgggc tccccaggcc tcagaagatc cccatctctg catga                      885


<210>  35
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Pro Ser Ala Gly Leu Cys Ser Cys Trp Gly Gly Arg Val Leu Pro 
1               5                   10                  15      


Leu Leu Leu Ala Tyr Val Cys Tyr Leu Leu Leu Gly Ala Thr Ile Phe 
            20                  25                  30          


Gln Leu Leu Glu Arg Gln Ala Glu Ala Gln Ser Arg Asp Gln Phe Gln 
        35                  40                  45              


Leu Glu Lys Leu Arg Phe Leu Glu Asn Tyr Thr Cys Leu Asp Gln Trp 
    50                  55                  60                  


Ala Met Glu Gln Phe Val Gln Val Ile Met Glu Ala Trp Val Lys Gly 
65                  70                  75                  80  


Val Asn Pro Lys Gly Asn Ser Thr Asn Pro Ser Asn Trp Asp Phe Gly 
                85                  90                  95      


Ser Ser Phe Phe Phe Ala Gly Thr Val Val Thr Thr Ile Gly Tyr Gly 
            100                 105                 110         


Asn Leu Ala Pro Ser Thr Glu Ala Gly Gln Val Phe Cys Val Phe Tyr 
        115                 120                 125             


Ala Leu Leu Gly Ile Pro Leu Asn Val Ile Phe Leu Asn His Leu Gly 
    130                 135                 140                 


Thr Gly Leu Arg Ala His Leu Ala Ala Ile Glu Arg Trp Glu Asp Arg 
145                 150                 155                 160 


Pro Arg Arg Ser Gln Val Leu Gln Val Leu Gly Leu Ala Leu Phe Leu 
                165                 170                 175     


Thr Leu Gly Thr Leu Val Ile Leu Ile Phe Pro Pro Met Val Phe Ser 
            180                 185                 190         


His Val Glu Gly Trp Ser Phe Ser Glu Gly Phe Tyr Phe Ala Phe Ile 
        195                 200                 205             


Thr Leu Ser Thr Ile Gly Phe Gly Asp Tyr Val Val Gly Thr Asp Pro 
    210                 215                 220                 


Ser Lys His Tyr Ile Ser Val Tyr Arg Ser Leu Ala Ala Ile Trp Ile 
225                 230                 235                 240 


Leu Leu Gly Leu Ala Trp Leu Ala Leu Ile Leu Pro Leu Gly Pro Leu 
                245                 250                 255     


Leu Leu His Arg Cys Cys Gln Leu Trp Leu Leu Ser Leu Arg Gln Gly 
            260                 265                 270         


Cys Gly Ala Lys Ala Ala Pro Gly Arg Arg Pro Arg Arg Gly Ser Thr 
        275                 280                 285             


Ala Ala Arg Gly Val Gln Val Thr Pro Gln Asp Phe Pro Ile Ser Lys 
    290                 295                 300                 


Lys Gly Leu Gly Ser 
305                 


<210>  36
<211>  910
<212>  DNA
<213>  Homo sapiens

<400>  36
atgcccagtg ctgggctctg cagctgctgg ggtggccggg tgctgcccct gctgctggcc       60

tatgtctgct acctgctgct cggtgccact atcttccagc tgctagagag gcaggcggag      120

gctcagtcca gggaccagtt tcagttggag aagctgcgct tcctggagaa ctacacctgc      180

ctggaccagt gggccatgga gcagtttgtg caggtcatca tggaagcctg ggtgaaaggt      240

gtgaacccca aaggcaactc taccaacccc agcaactggg actttggcag cagtttcttc      300

tttgcaggca cagtcgtcac taccatagga tatgggaacc tggcacccag cacagaggca      360

ggtcaggtct tctgtgtctt ctatgccctg ttgggcatcc cgcttaacgt gatcttcctc      420

aaccacctgg gcacagggct gcgtgcccat ctggccgcca ttgaaagatg ggaggaccgt      480

cccaggcgct cccaggtact gcaagtcctg ggcctggctc tgttcctgac cctggggacg      540

ctggtcattc tcatcttccc acccatggtc ttcagccatg tggagggctg gagcttcagc      600

gagggcttct actttgcttt catcactctc agcaccattg gctttgggga ctatgttgtt      660

ggcacagacc ccagcaagca ttatatctca gtgtatcgga gcctggcagc catctggatc      720

ctcctgggcc tggcgtggct ggcgctgatc ctcccactgg gccccctgct tctgcacaga      780

tgctgccagc tctggctgct cagtctgagg caaggctgtg gagccaaggc ggctccaggc      840

aggagaccca ggagaggctc tacagcagca agaggagtcc aagtcacacc ccaggacttc      900

cccatatcca                                                             910


<210>  37
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Tyr Arg Pro Arg Ala Arg Ala Ala Pro Glu Gly Arg Val Arg Gly 
1               5                   10                  15      


Cys Ala Val Pro Ser Thr Val Leu Leu Leu Leu Ala Tyr Leu Ala Tyr 
            20                  25                  30          


Leu Ala Leu Gly Thr Gly Val Phe Trp Thr Leu Glu Gly Arg Ala Ala 
        35                  40                  45              


Gln Asp Ser Ser Arg Ser Phe Gln Arg Asp Lys Trp Glu Leu Leu Gln 
    50                  55                  60                  


Asn Phe Thr Cys Leu Asp Arg Pro Ala Leu Asp Ser Leu Ile Arg Asp 
65                  70                  75                  80  


Val Val Gln Ala Tyr Lys Asn Gly Ala Ser Leu Leu Ser Asn Thr Thr 
                85                  90                  95      


Ser Met Gly Arg Trp Glu Leu Val Gly Ser Phe Phe Phe Ser Val Ser 
            100                 105                 110         


Thr Ile Thr Thr Ile Gly Tyr Gly Asn Leu Ser Pro Asn Thr Met Ala 
        115                 120                 125             


Ala Arg Leu Phe Cys Ile Phe Phe Ala Leu Val Gly Ile Pro Leu Asn 
    130                 135                 140                 


Leu Val Val Leu Asn Arg Leu Gly His Leu Met Gln Gln Gly Val Asn 
145                 150                 155                 160 


His Trp Ala Ser Arg Leu Gly Gly Thr Trp Gln Asp Pro Asp Lys Ala 
                165                 170                 175     


Arg Trp Leu Ala Gly Ser Gly Ala Leu Leu Ser Gly Leu Leu Leu Phe 
            180                 185                 190         


Leu Leu Leu Pro Pro Leu Leu Phe Ser His Met Glu Gly Trp Ser Tyr 
        195                 200                 205             


Thr Glu Gly Phe Tyr Phe Ala Phe Ile Thr Leu Ser Thr Val Gly Phe 
    210                 215                 220                 


Gly Asp Tyr Val Ile Gly Met Asn Pro Ser Gln Arg Tyr Pro Leu Trp 
225                 230                 235                 240 


Tyr Lys Asn Met Val Ser Leu Trp Ile Leu Phe Gly Met Ala Trp Leu 
                245                 250                 255     


Ala Leu Ile Ile Lys Leu Ile Leu Ser Gln Leu Glu Thr Pro Gly Arg 
            260                 265                 270         


Val Cys Ser Cys Cys His His Ser Ser Lys Glu Asp Phe Lys Ser Gln 
        275                 280                 285             


Ser Trp Arg Gln Gly Pro Asp Arg Glu Pro Glu Ser His Ser Pro Gln 
    290                 295                 300                 


Gln Gly Cys Tyr Pro Glu Gly Pro Met Gly Ile Ile Gln His Leu Glu 
305                 310                 315                 320 


Pro Ser Ala His Ala Ala Gly Cys Gly Lys Asp Ser 
                325                 330         


<210>  38
<211>  999
<212>  DNA
<213>  Homo sapiens

<400>  38
atgtaccgac cgcgagcccg ggcggctccc gagggcaggg tccggggctg cgcggtgccc       60

agcaccgtgc tcctgctgct cgcctacctg gcttacctgg cgctgggcac cggcgtgttc      120

tggacgctgg agggccgcgc ggcgcaggac tccagccgca gcttccagcg cgacaagtgg      180

gagctgttgc agaacttcac gtgtctggac cgcccggcgc tggactcgct gatccgggat      240

gtcgtccaag catacaaaaa cggagccagc ctcctcagca acaccaccag catggggcgc      300

tgggagctcg tgggctcctt cttcttttct gtgtccacca tcaccaccat tggctatggc      360

aacctgagcc ccaacacgat ggctgcccgc ctcttctgca tcttctttgc ccttgtgggg      420

atcccactca acctcgtggt gctcaaccga ctggggcatc tcatgcagca gggagtaaac      480

cactgggcca gcaggctggg gggcacctgg caggatcctg acaaggcgcg gtggctggcg      540

ggctctggcg ccctcctctc gggcctcctg ctcttcctgc tgctgccacc gctgctcttc      600

tcccacatgg agggctggag ctacacagag ggcttctact tcgccttcat caccctcagc      660

accgtgggct tcggcgacta cgtgattgga atgaacccct cccagaggta cccactgtgg      720

tacaagaaca tggtgtccct gtggatcctc tttgggatgg catggctggc cttgatcatc      780

aaactcatcc tctcccagct ggagacgcca gggagggtat gttcctgctg ccaccacagc      840

tctaaggaag acttcaagtc ccaaagctgg agacagggac ctgaccggga gccagagtcc      900

cactccccac agcaaggatg ctatccagag ggacccatgg gaatcataca gcatctggaa      960

ccttctgctc acgctgcagg ctgtggcaag gacagctag                             999


<210>  39
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Glu Val Ser Gly His Pro Gln Ala Arg Arg Cys Cys Pro Glu Ala 
1               5                   10                  15      


Leu Gly Lys Leu Phe Pro Gly Leu Cys Phe Leu Cys Phe Leu Val Thr 
            20                  25                  30          


Tyr Ala Leu Val Gly Ala Val Val Phe Ser Ala Ile Glu Asp Gly Gln 
        35                  40                  45              


Val Leu Val Ala Ala Asp Asp Gly Glu Phe Glu Lys Phe Leu Glu Glu 
    50                  55                  60                  


Leu Cys Arg Ile Leu Asn Cys Ser Glu Thr Val Val Glu Asp Arg Lys 
65                  70                  75                  80  


Gln Asp Leu Gln Gly His Leu Gln Lys Val Lys Pro Gln Trp Phe Asn 
                85                  90                  95      


Arg Thr Thr His Trp Ser Phe Leu Ser Ser Leu Phe Phe Cys Cys Thr 
            100                 105                 110         


Val Phe Ser Thr Val Gly Tyr Gly Tyr Ile Tyr Pro Val Thr Arg Leu 
        115                 120                 125             


Gly Lys Tyr Leu Cys Met Leu Tyr Ala Leu Phe Gly Ile Pro Leu Met 
    130                 135                 140                 


Phe Leu Val Leu Thr Asp Thr Gly Asp Ile Leu Ala Thr Ile Leu Ser 
145                 150                 155                 160 


Thr Ser Tyr Asn Arg Phe Arg Lys Phe Pro Phe Phe Thr Arg Pro Leu 
                165                 170                 175     


Leu Ser Lys Trp Cys Pro Lys Ser Leu Phe Lys Lys Lys Pro Asp Pro 
            180                 185                 190         


Lys Pro Ala Asp Glu Ala Val Pro Gln Ile Ile Ile Ser Ala Glu Glu 
        195                 200                 205             


Leu Pro Gly Pro Lys Leu Gly Thr Cys Pro Ser Arg Pro Ser Cys Ser 
    210                 215                 220                 


Met Glu Leu Phe Glu Arg Ser His Ala Leu Glu Lys Gln Asn Thr Leu 
225                 230                 235                 240 


Gln Leu Pro Pro Gln Ala Met Glu Arg Ser Asn Ser Cys Pro Glu Leu 
                245                 250                 255     


Val Leu Gly Arg Leu Ser Tyr Ser Ile Ile Ser Asn Leu Asp Glu Val 
            260                 265                 270         


Gly Gln Gln Val Glu Arg Leu Asp Ile Pro Leu Pro Ile Ile Ala Leu 
        275                 280                 285             


Ile Val Phe Ala Tyr Ile Ser Cys Ala Ala Ala Ile Leu Pro Phe Trp 
    290                 295                 300                 


Glu Thr Gln Leu Asp Phe Glu Asn Ala Phe Tyr Phe Cys Phe Val Thr 
305                 310                 315                 320 


Leu Thr Thr Ile Gly Phe Gly Asp Thr Val Leu Glu His Pro Asn Phe 
                325                 330                 335     


Phe Leu Phe Phe Ser Ile Tyr Ile Ile Val Gly Met Glu Ile Val Phe 
            340                 345                 350         


Ile Ala Phe Lys Leu Val Gln Asn Arg Leu Ile Asp Ile Tyr Lys Asn 
        355                 360                 365             


Val Met Leu Phe Phe Ala Lys Gly Lys Phe Tyr His Leu Val Lys Lys 
    370                 375                 380                 


<210>  40
<211>  1155
<212>  DNA
<213>  Homo sapiens

<400>  40
atggaggtct cggggcaccc ccaggccagg agatgctgcc cagaggccct gggaaagctc       60

ttccctggcc tctgcttcct ctgctttctg gtgacctacg ccctggtggg tgctgtggtc      120

ttctctgcca ttgaggacgg ccaggtcctg gtggcagcag atgatggaga gtttgagaag      180

ttcttggagg agctctgcag aatcttgaac tgcagtgaaa cagtggtgga agacagaaaa      240

caggatctcc aggggcatct gcagaaggtg aagcctcagt ggtttaacag gaccacacac      300

tggtccttcc tgagctcgct ctttttctgc tgcacggtgt tcagcaccgt gggctatggc      360

tacatctacc ccgtcaccag gcttggcaag tacttgtgca tgctctatgc tctctttggt      420

atccccctga tgttcctcgt tctcacggac acaggcgaca tcctggcaac catcttatct      480

acatcttata atcggttccg aaaattccct ttctttaccc gccccctcct ctccaagtgg      540

tgccccaaat ctctcttcaa gaaaaaaccg gaccccaagc ccgcagatga agctgtccct      600

cagatcatca tcagtgctga agagcttcca ggccccaaac ttggcacatg tccttcacgc      660

ccaagctgca gcatggagct gtttgagaga tctcatgcgc tagagaaaca gaacacactg      720

caactgcccc cacaagccat ggagaggagt aactcgtgtc ccgaactggt gttgggaaga      780

ctctcatact ccatcatcag caacctggat gaagttggac agcaggtgga gaggttggac      840

atccccctcc ccatcattgc ccttattgtt tttgcctaca tttcctgtgc agctgccatc      900

ctccccttct gggagacaca gttggatttc gagaatgcct tctatttctg ctttgtcaca      960

ctcaccacca ttgggtttgg ggatactgtt ttagaacacc ctaacttctt cctgttcttc     1020

tccatttata tcatcgttgg aatggagatt gtgttcattg ctttcaagtt ggtgcaaaac     1080

aggctgattg acatatacaa aaatgttatg ctattctttg caaaagggaa gttttaccac     1140

cttgttaaaa agtga                                                      1155


