                         SEQUENCE LISTING

<110>  Allergan Plc
 
<120>  Heavy Chain Only Antibodies to PDGF

<130>  19865 (NTB)

<150>  US 62/205,191
<151>  2015-08-14

<150>  US 62/333,772
<151>  2016-05-09

<160>  58    

<170>  PatentIn version 3.5

<210>  1
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Thr Leu Ala Cys Leu Leu Leu Leu Gly Cys Gly Tyr Leu Ala 
1               5                   10                  15      


His Val Leu Ala Glu Glu Ala Glu Ile Pro Arg Glu Val Ile Glu Arg 
            20                  25                  30          


Leu Ala Arg Ser Gln Ile His Ser Ile Arg Asp Leu Gln Arg Leu Leu 
        35                  40                  45              


Glu Ile Asp Ser Val Gly Ser Glu Asp Ser Leu Asp Thr Ser Leu Arg 
    50                  55                  60                  


Ala His Gly Val His Ala Thr Lys His Val Pro Glu Lys Arg Pro Leu 
65                  70                  75                  80  


Pro Ile Arg Arg Lys Arg Ser Ile Glu Glu Ala Val Pro Ala Val Cys 
                85                  90                  95      


Lys Thr Arg Thr Val Ile Tyr Glu Ile Pro Arg Ser Gln Val Asp Pro 
            100                 105                 110         


Thr Ser Ala Asn Phe Leu Ile Trp Pro Pro Cys Val Glu Val Lys Arg 
        115                 120                 125             


Cys Thr Gly Cys Cys Asn Thr Ser Ser Val Lys Cys Gln Pro Ser Arg 
    130                 135                 140                 


Val His His Arg Ser Val Lys Val Ala Lys Val Glu Tyr Val Arg Lys 
145                 150                 155                 160 


Lys Pro Lys Leu Lys Glu Val Gln Val Arg Leu Glu Glu His Leu Glu 
                165                 170                 175     


Cys Ala Cys Ala Thr Thr Ser Leu Asn Pro Asp Tyr Arg Glu Glu Asp 
            180                 185                 190         


Thr Gly Arg Pro Arg Glu Ser Gly Lys Lys Arg Lys Arg Lys Arg Leu 
        195                 200                 205             


Lys Pro Thr 
    210     


<210>  2
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asn Arg Cys Trp Ala Leu Phe Leu Ser Leu Cys Cys Tyr Leu Arg 
1               5                   10                  15      


Leu Val Ser Ala Glu Gly Asp Pro Ile Pro Glu Glu Leu Tyr Glu Met 
            20                  25                  30          


Leu Ser Asp His Ser Ile Arg Ser Phe Asp Asp Leu Gln Arg Leu Leu 
        35                  40                  45              


His Gly Asp Pro Gly Glu Glu Asp Gly Ala Glu Leu Asp Leu Asn Met 
    50                  55                  60                  


Thr Arg Ser His Ser Gly Gly Glu Leu Glu Ser Leu Ala Arg Gly Arg 
65                  70                  75                  80  


Arg Ser Leu Gly Ser Leu Thr Ile Ala Glu Pro Ala Met Ile Ala Glu 
                85                  90                  95      


Cys Lys Thr Arg Thr Glu Val Phe Glu Ile Ser Arg Arg Leu Ile Asp 
            100                 105                 110         


Arg Thr Asn Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val Gln 
        115                 120                 125             


Arg Cys Ser Gly Cys Cys Asn Asn Arg Asn Val Gln Cys Arg Pro Thr 
    130                 135                 140                 


Gln Val Gln Leu Arg Pro Val Gln Val Arg Lys Ile Glu Ile Val Arg 
145                 150                 155                 160 


Lys Lys Pro Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His Leu 
                165                 170                 175     


Ala Cys Lys Cys Glu Thr Val Ala Ala Ala Arg Pro Val Thr Arg Ser 
            180                 185                 190         


Pro Gly Gly Ser Gln Glu Gln Arg Ala Lys Thr Pro Gln Thr Arg Val 
        195                 200                 205             


Thr Ile Arg Thr Val Arg Val Arg Arg Pro Pro Lys Gly Lys His Arg 
    210                 215                 220                 


Lys Phe Lys His Thr His Asp Lys Thr Ala Leu Lys Glu Thr Leu Gly 
225                 230                 235                 240 


Ala 
    


<210>  3
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  3

Glu Pro Lys Ser Cys Asp 
1               5       


<210>  4
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  4

Ala Ser Thr Lys Gly Pro 
1               5       


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  Can be repeated up to 8 times

<400>  5

Gly Gly Gly Gly Ser 
1               5   


<210>  6
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of bevacizumab

<400>  6

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro His Tyr Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  7
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of bevacizumab

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  8
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of ranibizumab

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asp Phe Thr His Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro Tyr Tyr Tyr Gly Thr Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  9
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ranibizumab

<400>  9

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  10
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36F3 VL

<400>  10

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Lys Gly Ile Thr Met Val Arg Gly Val Ile His Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36F3 CDR1

<400>  11

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36F3 CDR2

<400>  12

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36F3 CDR3

<400>  13

Ala Lys Asp Lys Gly Ile Thr Met Val Arg Gly Val Ile His Phe Asp 
1               5                   10                  15      


Tyr 
    


<210>  14
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36E10 VH

<400>  14

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asn Ser Gly Phe Phe Thr Leu Ser Gly Phe Ile Arg Tyr Lys 
            100                 105                 110         


Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36E10 CDR1

<400>  15

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36E10 CDR2

<400>  16

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  17
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36E10 CDR3

<400>  17

Ser Asn Ser Gly Phe Phe Thr Leu Ser Gly Phe Ile Arg Tyr Lys Phe 
1               5                   10                  15      


<210>  18
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36E8 VH

<400>  18

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asn Ser Glu Leu Phe Lys Val Asn Gly Val Ile Arg Tyr Asp 
            100                 105                 110         


Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36E8 CDR1

<400>  19

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36E8 CDR2

<400>  20

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  21
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36E8 CDR3

<400>  21

Ala Ser Asn Ser Glu Leu Phe Lys Val Asn Gly Val Ile Arg Tyr Asp 
1               5                   10                  15      


Phe 
    


<210>  22
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36C12 VH

<400>  22

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Ser Glu Ile Phe Met Val Lys Gly Val Ile Gln Tyr Asn 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36C12 CDR1

<400>  23

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36C12 CDR2

<400>  24

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  25
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36C12 CDR3

<400>  25

Arg Asn Ser Glu Ile Phe Met Val Lys Gly Val Ile Gln Tyr Asn Ser 
1               5                   10                  15      


<210>  26
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36A4 VH

<400>  26

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Pro Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Asn Gly Ile Phe Met Phe Arg Gly Val Ile Arg Tyr Lys 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36A4 CDR1

<400>  27

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36A4 CDR2

<400>  28

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  29
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36A4 CDR3

<400>  29

Arg Asn Asn Gly Ile Phe Met Phe Arg Gly Val Ile Arg Tyr Lys Ser 
1               5                   10                  15      


<210>  30
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36A3 VH

<400>  30

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asn Ser Val Phe Ser Thr Leu Lys Gly Phe Leu Gln Tyr Lys 
            100                 105                 110         


Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36A3 CDR1

<400>  31

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36A3 CDR2

<400>  32

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  33
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36A3 CDR3

<400>  33

Ser Asn Ser Val Phe Ser Thr Leu Lys Gly Phe Leu Gln Tyr Lys Phe 
1               5                   10                  15      


<210>  34
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36D9 VH

<400>  34

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gln Arg Gly Phe Ser Met Val Asn Gly Leu Ile Arg Tyr Lys 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36D9 CDR1

<400>  35

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36D9 CDR2

<400>  36

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  37
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36D9 CDR3

<400>  37

Ala Lys Gln Arg Gly Phe Ser Met Val Asn Gly Leu Ile Arg Tyr Lys 
1               5                   10                  15      


Ser 
    


<210>  38
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36E4 VH

<400>  38

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser His Arg Gly Phe Phe Met Phe Asn Glu Phe Leu Arg Phe Lys 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36E4 CDR1

<400>  39

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36E4 CDR2

<400>  40

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  41
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36E4 CDR3

<400>  41

Ala Ser His Arg Gly Phe Phe Met Phe Asn Glu Phe Leu Arg Phe Lys 
1               5                   10                  15      


Tyr 
    


<210>  42
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36E9 VH

<400>  42

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Lys Arg Ala Leu Phe Arg Phe Arg Glu Leu Phe Arg Ser Asn 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  43
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36E9 CDR1

<400>  43

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  44
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36E9 CDR2

<400>  44

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  45
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36G9 CDR3

<400>  45

Ala Ser His Arg Gly Phe Phe Met Phe Asn Glu Phe Leu Arg Phe Lys 
1               5                   10                  15      


Tyr 
    


<210>  46
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36G9 VH

<400>  46

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg His Asn Val Ile Ser Met Val Arg Ala Leu Phe His Ser His 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36G9 CDR1

<400>  47

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36G9 CDR2

<400>  48

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  49
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36G9 CDR3

<400>  49

Ser Arg His Asn Val Ile Ser Met Val Arg Ala Leu Phe His Ser His 
1               5                   10                  15      


Ser 
    


<210>  50
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36H4 VH

<400>  50

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Glu Ser Gly Ile Phe Lys Phe Arg Glu Phe Ile Arg Ser Lys 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36H4 CDR1

<400>  51

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36H4 CDR2

<400>  52

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  53
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36H4 CDR3

<400>  53

Ser Arg Glu Ser Gly Ile Phe Lys Phe Arg Glu Phe Ile Arg Ser Lys 
1               5                   10                  15      


Tyr 
    


<210>  54
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A33A8 VH

<400>  54

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Ser Ser Gly Gly Gln Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  55
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A1G2 VH

<400>  55

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Ser Glu Gly Phe Ser Ser Gly Glu His Ser Glu Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  56
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A1F8 VH

<400>  56

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Ser Glu Gly Tyr Ser Ser Glu Ala His Ser Gln Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  57
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2B6 VH

<400>  57

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ala Ala Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Ser Ser Gly Gly Gln Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  58
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A1B1 VH

<400>  58

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Tyr Ala Ala Phe 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Ser Asp Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Ser Ser Gly Gly Gln Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


