                               SEQUENCE LISTING

<110> THE BROAD INSTITUTE, INC.
      THE GENERAL HOSPITAL CORPORATION
      PRESIDENT AND FELLOWS OF HARVARD COLLEGE
 
<120> COMPOSITIONS AND METHODS FOR TREATING MULTIPLE MYELOMA

<130> 167741.011001/PCT

<140> PCT/US2016/046856
<141> 2016-08-12

<150> 62/205,382
<151> 2015-08-14

<160> 10     

<170> PatentIn version 3.5

<210> 1
<211> 448
<212> PRT
<213> Homo sapiens

<400> 1
Met Lys Gly Phe Ile Asp Asp Ala Asn Tyr Ser Val Gly Leu Leu Asp 
1               5                   10                  15      


Glu Gly Thr Asn Leu Gly Asn Val Ile Asp Asn Tyr Val Tyr Glu His 
            20                  25                  30          


Thr Leu Thr Gly Lys Asn Ala Phe Phe Val Gly Asp Leu Gly Lys Ile 
        35                  40                  45              


Val Lys Lys His Ser Gln Trp Gln Asn Val Val Ala Gln Ile Lys Pro 
    50                  55                  60                  


Phe Tyr Thr Val Lys Cys Asn Ser Ala Pro Ala Val Leu Glu Ile Leu 
65                  70                  75                  80  


Ala Ala Leu Gly Thr Gly Phe Ala Cys Ser Ser Lys Asn Glu Met Ala 
                85                  90                  95      


Leu Val Gln Glu Leu Gly Val Pro Pro Glu Asn Ile Ile Tyr Ile Ser 
            100                 105                 110         


Pro Cys Lys Gln Val Ser Gln Ile Lys Tyr Ala Ala Lys Val Gly Val 
        115                 120                 125             


Asn Ile Leu Thr Cys Asp Asn Glu Ile Glu Leu Lys Lys Ile Ala Arg 
    130                 135                 140                 


Asn His Pro Asn Ala Lys Val Leu Leu His Ile Ala Thr Glu Asp Asn 
145                 150                 155                 160 


Ile Gly Gly Glu Glu Gly Asn Met Lys Phe Gly Thr Thr Leu Lys Asn 
                165                 170                 175     


Cys Arg His Leu Leu Glu Cys Ala Lys Glu Leu Asp Val Gln Ile Ile 
            180                 185                 190         


Gly Val Lys Phe His Val Ser Ser Ala Cys Lys Glu Ser Gln Val Tyr 
        195                 200                 205             


Val His Ala Leu Ser Asp Ala Arg Cys Val Phe Asp Met Ala Gly Glu 
    210                 215                 220                 


Ile Gly Phe Thr Met Asn Met Leu Asp Ile Gly Gly Gly Phe Thr Gly 
225                 230                 235                 240 


Thr Glu Phe Gln Leu Glu Glu Val Asn His Val Ile Ser Pro Leu Leu 
                245                 250                 255     


Asp Ile Tyr Phe Pro Glu Gly Ser Gly Val Lys Ile Ile Ser Glu Pro 
            260                 265                 270         


Gly Ser Tyr Tyr Val Ser Ser Ala Phe Thr Leu Ala Val Asn Ile Ile 
        275                 280                 285             


Ala Lys Lys Val Val Glu Asn Asp Lys Phe Pro Ser Gly Val Glu Lys 
    290                 295                 300                 


Thr Gly Ser Asp Glu Pro Ala Phe Met Tyr Tyr Met Asn Asp Gly Val 
305                 310                 315                 320 


Tyr Gly Ser Phe Ala Ser Lys Leu Ser Glu Asp Leu Asn Thr Ile Pro 
                325                 330                 335     


Glu Val His Lys Lys Tyr Lys Glu Asp Glu Pro Leu Phe Thr Ser Ser 
            340                 345                 350         


Leu Trp Gly Pro Ser Cys Asp Glu Leu Asp Gln Ile Val Glu Ser Cys 
        355                 360                 365             


Leu Leu Pro Glu Leu Asn Val Gly Asp Trp Leu Ile Phe Asp Asn Met 
    370                 375                 380                 


Gly Ala Asp Ser Phe His Glu Pro Ser Ala Phe Asn Asp Phe Gln Arg 
385                 390                 395                 400 


Pro Ala Ile Tyr Tyr Met Met Ser Phe Ser Asp Trp Tyr Glu Met Gln 
                405                 410                 415     


Asp Ala Gly Ile Thr Ser Asp Ser Met Met Lys Asn Phe Phe Phe Val 
            420                 425                 430         


Pro Ser Cys Ile Gln Leu Ser Gln Glu Asp Ser Phe Ser Ala Glu Ala 
        435                 440                 445             


<210> 2
<211> 4239
<212> DNA
<213> Homo sapiens

<400> 2
ctaatataaa tactggcgtc gctggcgccg ccttctcaca ctttcaggct ctgatcgcgg       60

ccgcagtttt tccttttttc ttctgccgtc gccttctctg cctcttctca tcctttctcg      120

ctctgctgct ctgcagtgtg acgagtccga atcctcttcc cacccagccc gcgcctttct      180

tcttttgcct gcgctgttct atttctcctt cggccgccgc cgccactgct gcacacagct      240

ggtgtcggtg ccgcgctttt acccccaagt cgttcccgca gcctatggcc caggccgcct      300

tgggtatttc tgctcaaggt aaccacatcc ctctttaaaa attccgccga aaaagagaag      360

acgctttacc cgactctttg ggccgttatc tcacggcgaa ctttctgacc aagtatacaa      420

ctacccagag ggcctaggag aagtgctgta tagagagcag ttcgacttca acgctgagcc      480

accttgggaa cctagctgat gatagggggg ttccatctcc caacttgtcc attttgttgc      540

atattctaag gacccagaca taggcttggt ggcccgtctc ttgtctttcc tggtttatga      600

ctttcggctt tgtggaatac ggctgagatg aaaggattta ttgatgatgc aaactactcc      660

gttggcctgt tggatgaagg aacaaacctt ggaaatgtta ttgataacta tgtttatgaa      720

cataccctga cagggaaaaa tgcatttttt gtgggagatc ttggaaagat tgtgaagaaa      780

cacagtcaat ggcagaatgt agtggctcag ataaagccat tctacacagt gaagtgcaac      840

tctgctccag ctgtacttga gattttggca gctcttggaa ccggatttgc ttgttccagt      900

aaaaatgaaa tggctttagt gcaagagttg ggtgtacctc cagaaaacat tatttacata      960

agtccttgca agcaagtgtc tcagataaag tatgcagcaa aagttggagt gaatatcctg     1020

acatgtgaca atgaaattga attgaagaaa attgcacgta atcacccaaa tgccaaggtc     1080

ttactacata ttgcaacaga agataatatt ggaggtgaag agggtaacat gaagtttggc     1140

actaccctga agaactgtag gcatctcttg gaatgtgcta aggaacttga tgtccaaata     1200

attggggtta aatttcatgt ttcgagtgct tgcaaagaat ctcaagtata tgtacatgct     1260

ctatctgatg ctcgatgtgt gtttgacatg gctggagaaa ttggctttac gatgaacatg     1320

ttagacattg gtggaggatt cacgggaact gaatttcaat tggaagaggt taatcatgtt     1380

atcagccctc tgttggatat ctactttcct gaaggatctg gtgttaagat aatttcagaa     1440

cccggaagct actatgtgtc ttctgcattt acactcgcag ttaatatcat agcaaagaaa     1500

gttgttgaaa atgataaatt tccctctgga gtagaaaaaa ccggaagtga tgaaccagcc     1560

ttcatgtatt atatgaatga tggtgtttat ggttcttttg caagtaaact gtctgaggac     1620

ttaaatacca ttccagaggt tcacaagaaa tacaaggaag atgagcctct gtttacaagc     1680

agcctttggg gtccatcctg tgatgagctt gatcaaattg tggaaagctg tcttcttcct     1740

gagctgaatg tgggagattg gcttatcttt gataacatgg gagcagattc tttccatgaa     1800

ccatctgctt ttaatgattt tcagaggcca gccatttatt acatgatgtc attcagtgat     1860

tggtatgaga tgcaagatgc tggaattact tcagactcaa tgatgaagaa cttcttcttt     1920

gtgccttctt gcattcagct gagccaagaa gacagctttt ccgctgaagc ttaaacaggc     1980

attaacgctt ctttagatct gaagttgcag gttaagcttg tctggtcaac attccagtgt     2040

ggaaaaataa tttaaacaat cttattctct taattctttt ggcaacaaaa actattagta     2100

atagctattt gggaccagac aaaatcagct ttcatctata attcattggg gataatggga     2160

gatttagata atgtatccag atttaaacct accagtttgt cctacccctt aagcgtttaa     2220

aataaaatat gcaacaaaat ggatgactta gtggagatgg aagcccatta attgggttcc     2280

ccattaaatc gtttacatac aagaacacag tttttatact aaggatttgt gtttaaagtc     2340

ttgtaaagtt catgtctttc acccagatat atcaaatgtt agaagaccag tgtgacttca     2400

ttagataacg tttagtgtat ttagaatgtg taaatttgtg ctttgaactg tagtttaata     2460

aatgtaaaat tgcatcatag tatttgttga cctaatgtaa cccttgtatg attgcaataa     2520

aattttgtgt agattttact gttttttcag gctaaaactt tgggaaaggg gctagctagc     2580

aaaggtagtt ttgaaataga tgtgtatatg gactgttttg aagggttttt ttctttatag     2640

cccagttaag ttttgtttgg ctcggtgcat ttttcattta tttaattagt aatttaagta     2700

aagtgtttgg taaatcattg tgaagttcag attcattatg gagagttgat gtgcagtaag     2760

catgatgttt aacaatttta acaccaaaaa tgttaatcct gcataaatca actgtaataa     2820

taaataggtg tttctgtata gatagaatgc atagagtacc ttagtaaatc tttgaatcac     2880

aatcttttgg ctgaaatgga agattctgtt aaatactttg aataaacttg gggggaggga     2940

aataaaattg cagaaaactg cagagcacta aaacttaaag aagggctaca tctttatcca     3000

gaaacctgtt gctcttttgc acggaatgtt taaattcaga gttgggatgg gggttggggt     3060

gaagcacact tattatcttc agttgcagtg atttcaaatt taggattttt tgttgttggt     3120

ttgaactgtc cccttagttt cttgttattt ccaatttgtt ctgcttagtc attactttta     3180

attcttttct tactaaaatt ttatggtggt tgggggaagg gagttagcat cactaacctg     3240

acagttgttg ccaggaattt gctttgttta ctgctagtat attagaaatc ctagatctca     3300

gaatcacaat agtaataaac aacaggggtc attttttcct aacttactct gtgttcaggt     3360

gtggaatttc tgtctcccaa gaggaaatgt gacttcactt tggtgccaat ggacagaaaa     3420

ttctacctgt gctacatagg agaagtttgg aatgcactta atagctggtt tttacacctt     3480

gatttcgagg tggaaagaaa ttgatcatga atctctaata aatttaaatc tcttaaacca     3540

gtaggtgctt aatatttttt gatttgatta atgcccattt aaatctcatg ggttctatta     3600

aaaatatata tatatagggc cccaatccat tgccatcaaa ttgcccttgg acttttccaa     3660

ggtatattat ggggttttat gcaaaattcc aagctaccat gtaacttttt ttaaccattt     3720

aacaaggagg gggaactgtt tcctaccttc tttacatgtt gtgcattgtt gtggtccaga     3780

aatgccaaac ctttttaaag atggtgcaac tttgagtcct tggcttgact atacaggcct     3840

tgaacttcat ggcatatcaa ctttgccata tctgcaggag agctgttcta taagaaatag     3900

ctcagagttg caaatatcac atgtgaatga tacggtaact tttaagaaat gtctgtattg     3960

tatttgaaga ctgtttgcca taaatctgaa atttgaacct atgtatttca atttggtatg     4020

ctaaaaagtt ctgaattaat gtaaagtttt ttgttataat attgtaatct cagttcaaaa     4080

gttaactgca aatataaaac ccaatgattt ctatatagta aattgaactg taaaggtaac     4140

ttgtgtgtga ttctgaatac atagataaat gtttttattc ctcatgtttt actttggctt     4200

ctatctgaaa tagaggtaaa attttacata tcagcttta                            4239


<210> 3
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3
Arg Ile Ser Gly Leu Ile Tyr Glu Glu Thr Arg Gly Val Leu Lys 
1               5                   10                  15  


<210> 4
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4
Arg Gln Gly Arg Thr Leu Tyr Gly Phe Gly Gly 
1               5                   10      


<210> 5
<211> 12
<212> PRT
<213> Homo sapiens

<400> 5
Thr Val Thr Ala Met Asp Val Val Tyr Ala Leu Lys 
1               5                   10          


<210> 6
<211> 18
<212> PRT
<213> Homo sapiens

<400> 6
Val Phe Leu Glu Asn Val Ile Arg Asp Ala Val Thr Tyr Thr Glu His 
1               5                   10                  15      


Ala Lys 
        


<210> 7
<211> 11
<212> PRT
<213> Homo sapiens

<400> 7
Val Leu Arg Asp Asn Ile Gln Gly Ile Thr Lys 
1               5                   10      


<210> 8
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
ggaagaagac agctttccac aatttg                                            26


<210> 9
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
aggaagaaga cagctttcca caattt                                            26


<210> 10
<211> 26
<212> DNA
<213> Homo sapiens

<400> 10
gaagaagaca gctttccaca atttga                                            26


