                         SEQUENCE LISTING

<110>  Rhode Island Hospital
 
<120>  CIRCULATING BIOMARKER FOR BRUGADA SYNDROME

<130>  21486-625001WO

<150>  62/207,854
<151>  2015-08-20

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Gln Pro Leu Cys Pro Pro Leu Ser Glu Ser Trp Met Leu Ser 
1               5                   10                  15      


Ala Ala Trp Gly Pro Thr Arg Arg Pro Pro Pro Ser Asp Lys Asp Cys 
            20                  25                  30          


Gly Arg Ser Leu Val Ser Ser Pro Asp Ser Trp Gly Ser Thr Pro Ala 
        35                  40                  45              


Asp Ser Pro Val Ala Ser Pro Ala Arg Pro Gly Thr Leu Arg Asp Pro 
    50                  55                  60                  


Arg Ala Pro Ser Val Gly Arg Arg Gly Ala Arg Ser Ser Arg Leu Gly 
65                  70                  75                  80  


Ser Gly Gln Arg Gln Ser Ala Ser Glu Arg Glu Lys Leu Arg Met Arg 
                85                  90                  95      


Thr Leu Ala Arg Ala Leu His Glu Leu Arg Arg Phe Leu Pro Pro Ser 
            100                 105                 110         


Val Ala Pro Ala Gly Gln Ser Leu Thr Lys Ile Glu Thr Leu Arg Leu 
        115                 120                 125             


Ala Ile Arg Tyr Ile Gly His Leu Ser Ala Val Leu Gly Leu Ser Glu 
    130                 135                 140                 


Glu Ser Leu Gln Arg Arg Cys Arg Gln Arg Gly Asp Ala Gly Ser Pro 
145                 150                 155                 160 


Arg Gly Cys Pro Leu Cys Pro Asp Asp Cys Pro Ala Gln Met Gln Thr 
                165                 170                 175     


Arg Thr Gln Ala Glu Gly Gln Gly Gln Gly Arg Gly Leu Gly Leu Val 
            180                 185                 190         


Ser Ala Val Arg Ala Gly Ala Ser Trp Gly Ser Pro Pro Ala Cys Pro 
        195                 200                 205             


Gly Ala Arg Ala Ala Pro Glu Pro Arg Asp Pro Pro Ala Leu Phe Ala 
    210                 215                 220                 


Glu Ala Ala Cys Pro Glu Gly Gln Ala Met Glu Pro Ser Pro Pro Ser 
225                 230                 235                 240 


Pro Leu Leu Pro Gly Asp Val Leu Ala Leu Leu Glu Thr Trp Met Pro 
                245                 250                 255     


Leu Ser Pro Leu Glu Trp Leu Pro Glu Glu Pro Lys 
            260                 265             


<210>  2
<211>  1184
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MESP1 cDNA sequence.

<400>  2
tggaaggggc cacttcacac ctcgggctcg gcataaagcg gccgccggcc gccggccccc       60

agacgcgccg ccgctgccat ggcccagccc ctgtgcccgc cgctctccga gtcctggatg      120

ctctctgcgg cctggggccc aactcggcgg ccgccgccct ccgacaagga ctgcggccgc      180

tccctcgtct cgtccccaga ctcatggggc agcaccccag ccgacagccc cgtggcgagc      240

cccgcgcggc caggcaccct ccgggacccc cgcgccccct ccgtaggtag gcgcggcgcg      300

cgcagcagcc gcctgggcag cgggcagagg cagagcgcca gtgagcggga gaaactgcgc      360

atgcgcacgc tggcccgcgc cctgcacgag ctgcgccgct ttctaccgcc gtccgtggcg      420

cccgcgggcc agagcctgac caagatcgag acgctgcgcc tggctatccg ctatatcggc      480

cacctgtcgg ccgtgctagg cctcagcgag gagagtctcc agcgccggtg ccggcagcgc      540

ggtgacgcgg ggtcccctcg gggctgcccg ctgtgccccg acgactgccc cgcgcagatg      600

cagacacgga cgcaggctga ggggcagggg caggggcgcg ggctgggcct ggtatccgcc      660

gtccgcgccg gggcgtcctg gggatccccg cctgcctgcc ccggagcccg agctgcaccc      720

gagccgcgcg acccgcctgc gctgttcgcc gaggcggcgt gccctgaagg gcaggcgatg      780

gagccaagcc caccgtcccc gctccttccg ggcgacgtgc tggctctgtt ggagacctgg      840

atgcccctct cgcctctgga gtggctgcct gaggagccca agtgacaagg gacaactgac      900

gccgtctctg tgagcaccga ggctttttgg cctcagcacc ttcgaagtgg ttccttggca      960

gactgccttt cctggaagag ggcacgggcg atcccgacgg gggcattcct gcgggtgaga     1020

gccgtcccca ccgcggcggc ccttctcagc ccctccctcc atggagggac ccatagggct     1080

agacactttg aggcaagcag gaggctctgc ctaatgtgaa tttatttatt tgtgaataaa     1140

ctgtactggt gtcagttggc aaaaaaaaaa aaaaaaaaaa aaaa                      1184


<210>  3
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  3
ggagccctcc tagtgagtat gaagtgatat ctcactgagg ttttggtttg caaaagcaaa       60

tgactgatga ctaacgatgc aggacatctt tccatgtgca tgttggtcat ttatatatct      120

tccttggaga aatctctatt cagatcctta gctcattttt aattgggtta tttctcttct      180

tcttgttgag ttgtaagagt tctttacata ttctggatca cagtctctta tcagatatat      240

gatttaaaaa tattttctcc tagtctgtga gttttttcat ttcctagtgg tgtccattaa      300

agcacaaaag ttttacatgt t                                                321


<210>  4
<211>  164
<212>  DNA
<213>  Homo sapiens

<400>  4
gaactgcaca atgaccagca ggaggggaga agagagtagg aaaaaggagg gaaggacaga       60

catcaagtgc cagatgttgt ctgaactaat cgagcacttc tcaccaaact tcatgtataa      120

ataaaataca tatttttaaa acaaaccaat aaatggctta catg                       164


<210>  5
<211>  114
<212>  DNA
<213>  Homo sapiens

<400>  5
ggcactgtgc tctcggacat catccagaag tacttcttct ccccgacgct cttccgagtc       60

atccgcctgg cccgaatagg ccgcatcctc agactgatcc gaggggccaa gggg            114


<210>  6
<211>  5327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E38C Splice Variant cDNA Sequence

<400>  6
agacggcggc ggcgcccgta ggatgcaggg atcgctcccc cggggccgct gagcctgcgc       60

ccagtgcccc gagccccgcg ccgagccgag tccgcgccaa gcagcagccg cccaccccgg      120

ggcccggccg ggggaccagc agcttcccca caggcaacgt gaggagagcc tgtgcccaga      180

agcaggatga gaagatggca aacttcctat tacctcgggg caccagcagc ttccgcaggt      240

tcacacggga gtccctggca gccatcgaga agcgcatggc agagaagcaa gcccgcggct      300

caaccacctt gcaggagagc cgagaggggc tgcccgagga ggaggctccc cggccccagc      360

tggacctgca ggcctccaaa aagctgccag atctctatgg caatccaccc caagagctca      420

tcggagagcc cctggaggac ctggacccct tctatagcac ccaaaagact ttcatcgtac      480

tgaataaagg caagaccatc ttccggttca gtgccaccaa cgccttgtat gtcctcagtc      540

ccttccaccc catccggaga gcggctgtga agattctggt tcactcgctc ttcaacatgc      600

tcatcatgtg caccatcctc accaactgcg tgttcatggc ccagcacgac cctccaccct      660

ggaccaagta tgtcgagtac accttcaccg ccatttacac ctttgagtct ctggtcaaga      720

ttctggctcg aggcttctgc ctgcacgcgt tcactttcct tcgggaccca tggaactggc      780

tggactttag tgtgattatc atggcataca caactgaatt tgtggacctg ggcaatgtct      840

cagccttacg caccttccga gtcctccggg ccctgaaaac tatatcagtc atttcagggc      900

tgaagaccat cgtgggggcc ctgatccagt ctgtgaagaa gctggctgat gtgatggtcc      960

tcacagtctt ctgcctcagc gtctttgccc tcatcggcct gcagctcttc atgggcaacc     1020

taaggcacaa gtgcgtgcgc aacttcacag cgctcaacgg caccaacggc tccgtggagg     1080

ccgacggctt ggtctgggaa tccctggacc tttacctcag tgatccagaa aattacctgc     1140

tcaagaacgg cacctctgat gtgttactgt gtgggaacag ctctgacgct gggacatgtc     1200

cggagggcta ccggtgccta aaggcaggcg agaaccccga ccacggctac accagcttcg     1260

attcctttgc ctgggccttt cttgcactct tccgcctgat gacgcaggac tgctgggagc     1320

gcctctatca gcagaccctc aggtccgcag ggaagatcta catgatcttc ttcatgcttg     1380

tcatcttcct ggggtccttc tacctggtga acctgatcct ggccgtggtc gcaatggcct     1440

atgaggagca aaaccaagcc accatcgctg agaccgagga gaaggaaaag cgcttccagg     1500

aggccatgga aatgctcaag aaagaacacg aggccctcac catcaggggt gtggataccg     1560

tgtcccgtag ctccttggag atgtcccctt tggccccagt aaacagccat gagagaagaa     1620

gcaagaggag aaaacggatg tcttcaggaa ctgaggagtg tggggaggac aggctcccca     1680

agtctgactc agaagatggt cccagagcaa tgaatcatct cagcctcacc cgtggcctca     1740

gcaggacttc tatgaagcca cgttccagcc gcgggagcat tttcaccttt cgcaggcgag     1800

acctgggttc tgaagcagat tttgcagatg atgaaaacag cacagcgggg gagagcgaga     1860

gccaccacac atcactgctg gtgccctggc ccctgcgccg gaccagtgcc cagggacagc     1920

ccagtcccgg aacctcggct cctggccacg ccctccatgg caaaaagaac agcactgtgg     1980

actgcaatgg ggtggtctca ttactggggg caggcgaccc agaggccaca tccccaggaa     2040

gccacctcct ccgccctgtg atgctagagc acccgccaga cacgaccacg ccatcggagg     2100

agccaggcgg gccccagatg ctgacctccc aggctccgtg tgtagatggc ttcgaggagc     2160

caggagcacg gcagcgggcc ctcagcgcag tcagcgtcct caccagcgca ctggaagagt     2220

tagaggagtc tcgccacaag tgtccaccat gctggaaccg tctcgcccag cgctacctga     2280

tctgggagtg ctgcccgctg tggatgtcca tcaagcaggg agtgaagttg gtggtcatgg     2340

acccgtttac tgacctcacc atcactatgt gcatcgtact caacacactc ttcatggcgc     2400

tggagcacta caacatgaca agtgaattcg aggagatgct gcaggtcgga aacctggtct     2460

tcacagggat tttcacagca gagatgacct tcaagatcat tgccctcgac ccctactact     2520

acttccaaca gggctggaac atcttcgaca gcatcatcgt catccttagc ctcatggagc     2580

tgggcctgtc ccgcatgagc aacttgtcgg tgctgcgctc cttccgcctg ctgcgggtct     2640

tcaagctggc caaatcatgg cccaccctga acacactcat caagatcatc gggaactcag     2700

tgggggcact ggggaacctg acactggtgc tagccatcat cgtgttcatc tttgctgtgg     2760

tgggcatgca gctctttggc aagaactact cggagctgag ggacagcgac tcaggcctgc     2820

tgcctcgctg gcacatgatg gacttctttc atgccttcct catcatcttc cgcatcctct     2880

gtggagagtg gatcgagacc atgtgggact gcatggaggt gtcggggcag tcattatgcc     2940

tgctggtctt cttgcttgtt atggtcattg gcaaccttgt ggtcctgaat ctcttcctgg     3000

ccttgctgct cagctccttc agtgcagaca acctcacagc ccctgatgag gacagagaga     3060

tgaacaacct ccagctggcc ctggcccgca tccagagggg cctgcgcttt gtcaagcgga     3120

ccacctggga tttctgctgt ggtctcctgc ggcagcggcc tcagaagccc gcagcccttg     3180

ccgcccaggg ccagctgccc agctgcattg ccacccccta ctccccgcca cccccagaga     3240

cggagaaggt gcctcccacc cgcaaggaaa cacggtttga ggaaggcgag caaccaggcc     3300

agggcacccc cggggatcca gagcccgtgt gtgtgcccat cgctgtggcc gagtcagaca     3360

cagatgacca agaagaagat gaggagaaca gcctgggcac ggaggaggag tccagcaagc     3420

agcaggaatc ccagcctgtg tccggtggcc cagaggcccc tccggattcc aggacctgga     3480

gccaggtgtc agcgactgcc tcctctgagg ccgaggccag tgcatctcag gccgactggc     3540

ggcagcagtg gaaagcggaa ccccaggccc cagggtgcgg tgagacccca gaggacagtt     3600

gctccgaggg cagcacagca gacatgacca acaccgctga gctcctggag cagatccctg     3660

acctcggcca ggatgtcaag gacccagagg actgcttcac tgaaggctgt gtccggcgct     3720

gtccctgctg tgcggtggac accacacagg ccccagggaa ggtctggtgg cggttgcgca     3780

agacctgcta ccacatcgtg gagcacagct ggttcgagac attcatcatc ttcatgatcc     3840

tactcagcag tggagcgctg gccttcgagg acatctacct agaggagcgg aagaccatca     3900

aggttctgct tgagtatgcc gacaagatgt tcacatatgt cttcgtgctg gagatgctgc     3960

tcaagtgggt ggcctacggc ttcaagaagt acttcaccaa tgcctggtgc tggctcgact     4020

tcctcatcgt agacgtctct ctggtcagcc tggtggccaa caccctgggc tttgccgaga     4080

tgggccccat caagtcactg cggacgctgc gtgcactccg tcctctgaga gctctgtcac     4140

gatttgaggg catgagggtg gtggtcaatg ccctggtggg cgccatcccg tccatcatga     4200

acgtcctcct cgtctgcctc atcttctggc tcatcttcag catcatgggc gtgaacctct     4260

ttgcggggaa gtttgggagg tgcatcaacc agacagaggg agacttgcct ttgaactaca     4320

ccatcgtgaa caacaagagc cagtgtgagt ccttgaactt gaccggagaa ttgtactgga     4380

ccaaggtgaa agtcaacttt gacaacgtgg gggccgggta cctggccctt ctgcaggtgg     4440

caacatttaa aggctggatg gacattatgt atgcagctgt ggactccagg gggtatgaag     4500

agcagcctca gtgggaatac aacctctaca tgtacatcta ttttgtcatt ttcatcatct     4560

ttgggtcttt cttcaccctg aacctcttta ttggtgtcat cattgacaac ttcaaccaac     4620

agaagaaaaa gttagggggc caggacatct tcatgacaga ggagcagaag aagtactaca     4680

atgccatgaa gaagctgggc tccaagaagc cccagaagcc catcccacgg cccctgaaca     4740

agtaccaggg cttcatattc gacattgtga ccaagcaggc ctttgacgtc accatcatgt     4800

ttctgatctg cttgaatatg gtgaccatga tggtggagac agatgaccaa agtcctgaga     4860

aaatcaacat cttggccaag atcaacctgc tctttgtggc catcttcaca ggcgagtgta     4920

ttgtcaagct ggctgccctg cgccactact acttcaccaa cagctggaat atcttcgact     4980

tcgtggttgt catcctctcc atcgtgggag ccctcctagt gagtatgaag tgatatctca     5040

ctgaggtttt ggtttgcaaa agcaaatgac tgatgactaa cgatgcagga catctttcca     5100

tgtgcatgtt ggtcatttat atatcttcct tggagaaatc tctattcaga tccttagctc     5160

atttttaatt gggttatttc tcttcttctt gttgagttgt aagagttctt tacatattct     5220

ggatcacagt ctcttatcag atatatgatt taaaaatatt ttctcctagt ctgtgagttt     5280

tttcatttcc tagtggtgtc cattaaagca caaaagtttt acatgtt                   5327


<210>  7
<211>  1612
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser Phe Arg Arg Phe 
1               5                   10                  15      


Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met Ala Glu Lys Gln 
            20                  25                  30          


Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu Gly Leu Pro Glu 
        35                  40                  45              


Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala Ser Lys Lys Leu 
    50                  55                  60                  


Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile Gly Glu Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr Asn Ala Leu Tyr 
            100                 105                 110         


Val Leu Ser Pro Phe His Pro Ile Arg Arg Ala Ala Val Lys Ile Leu 
        115                 120                 125             


Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp Thr Lys Tyr Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Leu His Ala Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala Tyr Thr Thr Glu 
        195                 200                 205             


Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Ser Val Ile Ser Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp Val Met Val Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe Thr Ala Leu Asn 
        275                 280                 285             


Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val Trp Glu Ser Leu 
    290                 295                 300                 


Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu Lys Asn Gly Thr 
305                 310                 315                 320 


Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Thr Cys Pro 
                325                 330                 335     


Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro Asp His Gly Tyr 
            340                 345                 350         


Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala Leu Phe Arg Leu 
        355                 360                 365             


Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Ser 
    370                 375                 380                 


Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val Ile Phe Leu Gly 
385                 390                 395                 400 


Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr 
                405                 410                 415     


Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr Glu Glu Lys Glu Lys 
            420                 425                 430         


Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys Glu His Glu Ala Leu 
        435                 440                 445             


Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser Ser Leu Glu Met Ser 
    450                 455                 460                 


Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg Ser Lys Arg Arg Lys 
465                 470                 475                 480 


Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu Asp Arg Leu Pro Lys 
                485                 490                 495     


Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn His Leu Ser Leu Thr 
            500                 505                 510         


Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg Ser Ser Arg Gly Ser 
        515                 520                 525             


Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser Glu Ala Asp Phe Ala 
    530                 535                 540                 


Asp Asp Glu Asn Ser Thr Ala Gly Glu Ser Glu Ser His His Thr Ser 
545                 550                 555                 560 


Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser Ala Gln Gly Gln Pro 
                565                 570                 575     


Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu His Gly Lys Lys Asn 
            580                 585                 590         


Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Leu Gly Ala Gly Asp 
        595                 600                 605             


Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu Arg Pro Val Met Leu 
    610                 615                 620                 


Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu Glu Pro Gly Gly Pro 
625                 630                 635                 640 


Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp Gly Phe Glu Glu Pro 
                645                 650                 655     


Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser Val Leu Thr Ser Ala 
            660                 665                 670         


Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys Pro Pro Cys Trp Asn 
        675                 680                 685             


Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys Cys Pro Leu Trp Met 
    690                 695                 700                 


Ser Ile Lys Gln Gly Val Lys Leu Val Val Met Asp Pro Phe Thr Asp 
705                 710                 715                 720 


Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr Leu Phe Met Ala Leu 
                725                 730                 735     


Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met Leu Gln Val Gly 
            740                 745                 750         


Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Thr Phe Lys Ile 
        755                 760                 765             


Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln Gly Trp Asn Ile Phe 
    770                 775                 780                 


Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu Leu Gly Leu Ser Arg 
785                 790                 795                 800 


Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
                805                 810                 815     


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile 
            820                 825                 830         


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
        835                 840                 845             


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Asn 
    850                 855                 860                 


Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu Leu Pro Arg Trp His 
865                 870                 875                 880 


Met Met Asp Phe Phe His Ala Phe Leu Ile Ile Phe Arg Ile Leu Cys 
                885                 890                 895     


Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ser Gly Gln 
            900                 905                 910         


Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met Val Ile Gly Asn Leu 
        915                 920                 925             


Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ala 
    930                 935                 940                 


Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu Met Asn Asn Leu Gln 
945                 950                 955                 960 


Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg Phe Val Lys Arg Thr 
                965                 970                 975     


Thr Trp Asp Phe Cys Cys Gly Leu Leu Arg Gln Arg Pro Gln Lys Pro 
            980                 985                 990         


Ala Ala Leu Ala Ala Gln Gly Gln  Leu Pro Ser Cys Ile  Ala Thr Pro 
        995                 1000                 1005             


Tyr Ser  Pro Pro Pro Pro Glu  Thr Glu Lys Val Pro  Pro Thr Arg 
    1010                 1015                 1020             


Lys Glu  Thr Arg Phe Glu Glu  Gly Glu Gln Pro Gly  Gln Gly Thr 
    1025                 1030                 1035             


Pro Gly  Asp Pro Glu Pro Val  Cys Val Pro Ile Ala  Val Ala Glu 
    1040                 1045                 1050             


Ser Asp  Thr Asp Asp Gln Glu  Glu Asp Glu Glu Asn  Ser Leu Gly 
    1055                 1060                 1065             


Thr Glu  Glu Glu Ser Ser Lys  Gln Gln Glu Ser Gln  Pro Val Ser 
    1070                 1075                 1080             


Gly Gly  Pro Glu Ala Pro Pro  Asp Ser Arg Thr Trp  Ser Gln Val 
    1085                 1090                 1095             


Ser Ala  Thr Ala Ser Ser Glu  Ala Glu Ala Ser Ala  Ser Gln Ala 
    1100                 1105                 1110             


Asp Trp  Arg Gln Gln Trp Lys  Ala Glu Pro Gln Ala  Pro Gly Cys 
    1115                 1120                 1125             


Gly Glu  Thr Pro Glu Asp Ser  Cys Ser Glu Gly Ser  Thr Ala Asp 
    1130                 1135                 1140             


Met Thr  Asn Thr Ala Glu Leu  Leu Glu Gln Ile Pro  Asp Leu Gly 
    1145                 1150                 1155             


Gln Asp  Val Lys Asp Pro Glu  Asp Cys Phe Thr Glu  Gly Cys Val 
    1160                 1165                 1170             


Arg Arg  Cys Pro Cys Cys Ala  Val Asp Thr Thr Gln  Ala Pro Gly 
    1175                 1180                 1185             


Lys Val  Trp Trp Arg Leu Arg  Lys Thr Cys Tyr His  Ile Val Glu 
    1190                 1195                 1200             


His Ser  Trp Phe Glu Thr Phe  Ile Ile Phe Met Ile  Leu Leu Ser 
    1205                 1210                 1215             


Ser Gly  Ala Leu Ala Phe Glu  Asp Ile Tyr Leu Glu  Glu Arg Lys 
    1220                 1225                 1230             


Thr Ile  Lys Val Leu Leu Glu  Tyr Ala Asp Lys Met  Phe Thr Tyr 
    1235                 1240                 1245             


Val Phe  Val Leu Glu Met Leu  Leu Lys Trp Val Ala  Tyr Gly Phe 
    1250                 1255                 1260             


Lys Lys  Tyr Phe Thr Asn Ala  Trp Cys Trp Leu Asp  Phe Leu Ile 
    1265                 1270                 1275             


Val Asp  Val Ser Leu Val Ser  Leu Val Ala Asn Thr  Leu Gly Phe 
    1280                 1285                 1290             


Ala Glu  Met Gly Pro Ile Lys  Ser Leu Arg Thr Leu  Arg Ala Leu 
    1295                 1300                 1305             


Arg Pro  Leu Arg Ala Leu Ser  Arg Phe Glu Gly Met  Arg Val Val 
    1310                 1315                 1320             


Val Asn  Ala Leu Val Gly Ala  Ile Pro Ser Ile Met  Asn Val Leu 
    1325                 1330                 1335             


Leu Val  Cys Leu Ile Phe Trp  Leu Ile Phe Ser Ile  Met Gly Val 
    1340                 1345                 1350             


Asn Leu  Phe Ala Gly Lys Phe  Gly Arg Cys Ile Asn  Gln Thr Glu 
    1355                 1360                 1365             


Gly Asp  Leu Pro Leu Asn Tyr  Thr Ile Val Asn Asn  Lys Ser Gln 
    1370                 1375                 1380             


Cys Glu  Ser Leu Asn Leu Thr  Gly Glu Leu Tyr Trp  Thr Lys Val 
    1385                 1390                 1395             


Lys Val  Asn Phe Asp Asn Val  Gly Ala Gly Tyr Leu  Ala Leu Leu 
    1400                 1405                 1410             


Gln Val  Ala Thr Phe Lys Gly  Trp Met Asp Ile Met  Tyr Ala Ala 
    1415                 1420                 1425             


Val Asp  Ser Arg Gly Tyr Glu  Glu Gln Pro Gln Trp  Glu Tyr Asn 
    1430                 1435                 1440             


Leu Tyr  Met Tyr Ile Tyr Phe  Val Ile Phe Ile Ile  Phe Gly Ser 
    1445                 1450                 1455             


Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val Ile Ile  Asp Asn Phe 
    1460                 1465                 1470             


Asn Gln  Gln Lys Lys Lys Leu  Gly Gly Gln Asp Ile  Phe Met Thr 
    1475                 1480                 1485             


Glu Glu  Gln Lys Lys Tyr Tyr  Asn Ala Met Lys Lys  Leu Gly Ser 
    1490                 1495                 1500             


Lys Lys  Pro Gln Lys Pro Ile  Pro Arg Pro Leu Asn  Lys Tyr Gln 
    1505                 1510                 1515             


Gly Phe  Ile Phe Asp Ile Val  Thr Lys Gln Ala Phe  Asp Val Thr 
    1520                 1525                 1530             


Ile Met  Phe Leu Ile Cys Leu  Asn Met Val Thr Met  Met Val Glu 
    1535                 1540                 1545             


Thr Asp  Asp Gln Ser Pro Glu  Lys Ile Asn Ile Leu  Ala Lys Ile 
    1550                 1555                 1560             


Asn Leu  Leu Phe Val Ala Ile  Phe Thr Gly Glu Cys  Ile Val Lys 
    1565                 1570                 1575             


Leu Ala  Ala Leu Arg His Tyr  Tyr Phe Thr Asn Ser  Trp Asn Ile 
    1580                 1585                 1590             


Phe Asp  Phe Val Val Val Ile  Leu Ser Ile Val Gly  Ala Leu Leu 
    1595                 1600                 1605             


Val Ser  Met Lys 
    1610         


<210>  8
<211>  5170
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E28C Splice Variant cDNA Sequence

<400>  8
agacggcggc ggcgcccgta ggatgcaggg atcgctcccc cggggccgct gagcctgcgc       60

ccagtgcccc gagccccgcg ccgagccgag tccgcgccaa gcagcagccg cccaccccgg      120

ggcccggccg ggggaccagc agcttcccca caggcaacgt gaggagagcc tgtgcccaga      180

agcaggatga gaagatggca aacttcctat tacctcgggg caccagcagc ttccgcaggt      240

tcacacggga gtccctggca gccatcgaga agcgcatggc agagaagcaa gcccgcggct      300

caaccacctt gcaggagagc cgagaggggc tgcccgagga ggaggctccc cggccccagc      360

tggacctgca ggcctccaaa aagctgccag atctctatgg caatccaccc caagagctca      420

tcggagagcc cctggaggac ctggacccct tctatagcac ccaaaagact ttcatcgtac      480

tgaataaagg caagaccatc ttccggttca gtgccaccaa cgccttgtat gtcctcagtc      540

ccttccaccc catccggaga gcggctgtga agattctggt tcactcgctc ttcaacatgc      600

tcatcatgtg caccatcctc accaactgcg tgttcatggc ccagcacgac cctccaccct      660

ggaccaagta tgtcgagtac accttcaccg ccatttacac ctttgagtct ctggtcaaga      720

ttctggctcg aggcttctgc ctgcacgcgt tcactttcct tcgggaccca tggaactggc      780

tggactttag tgtgattatc atggcataca caactgaatt tgtggacctg ggcaatgtct      840

cagccttacg caccttccga gtcctccggg ccctgaaaac tatatcagtc atttcagggc      900

tgaagaccat cgtgggggcc ctgatccagt ctgtgaagaa gctggctgat gtgatggtcc      960

tcacagtctt ctgcctcagc gtctttgccc tcatcggcct gcagctcttc atgggcaacc     1020

taaggcacaa gtgcgtgcgc aacttcacag cgctcaacgg caccaacggc tccgtggagg     1080

ccgacggctt ggtctgggaa tccctggacc tttacctcag tgatccagaa aattacctgc     1140

tcaagaacgg cacctctgat gtgttactgt gtgggaacag ctctgacgct gggacatgtc     1200

cggagggcta ccggtgccta aaggcaggcg agaaccccga ccacggctac accagcttcg     1260

attcctttgc ctgggccttt cttgcactct tccgcctgat gacgcaggac tgctgggagc     1320

gcctctatca gcagaccctc aggtccgcag ggaagatcta catgatcttc ttcatgcttg     1380

tcatcttcct ggggtccttc tacctggtga acctgatcct ggccgtggtc gcaatggcct     1440

atgaggagca aaaccaagcc accatcgctg agaccgagga gaaggaaaag cgcttccagg     1500

aggccatgga aatgctcaag aaagaacacg aggccctcac catcaggggt gtggataccg     1560

tgtcccgtag ctccttggag atgtcccctt tggccccagt aaacagccat gagagaagaa     1620

gcaagaggag aaaacggatg tcttcaggaa ctgaggagtg tggggaggac aggctcccca     1680

agtctgactc agaagatggt cccagagcaa tgaatcatct cagcctcacc cgtggcctca     1740

gcaggacttc tatgaagcca cgttccagcc gcgggagcat tttcaccttt cgcaggcgag     1800

acctgggttc tgaagcagat tttgcagatg atgaaaacag cacagcgggg gagagcgaga     1860

gccaccacac atcactgctg gtgccctggc ccctgcgccg gaccagtgcc cagggacagc     1920

ccagtcccgg aacctcggct cctggccacg ccctccatgg caaaaagaac agcactgtgg     1980

actgcaatgg ggtggtctca ttactggggg caggcgaccc agaggccaca tccccaggaa     2040

gccacctcct ccgccctgtg atgctagagc acccgccaga cacgaccacg ccatcggagg     2100

agccaggcgg gccccagatg ctgacctccc aggctccgtg tgtagatggc ttcgaggagc     2160

caggagcacg gcagcgggcc ctcagcgcag tcagcgtcct caccagcgca ctggaagagt     2220

tagaggagtc tcgccacaag tgtccaccat gctggaaccg tctcgcccag cgctacctga     2280

tctgggagtg ctgcccgctg tggatgtcca tcaagcaggg agtgaagttg gtggtcatgg     2340

acccgtttac tgacctcacc atcactatgt gcatcgtact caacacactc ttcatggcgc     2400

tggagcacta caacatgaca agtgaattcg aggagatgct gcaggtcgga aacctggtct     2460

tcacagggat tttcacagca gagatgacct tcaagatcat tgccctcgac ccctactact     2520

acttccaaca gggctggaac atcttcgaca gcatcatcgt catccttagc ctcatggagc     2580

tgggcctgtc ccgcatgagc aacttgtcgg tgctgcgctc cttccgcctg ctgcgggtct     2640

tcaagctggc caaatcatgg cccaccctga acacactcat caagatcatc gggaactcag     2700

tgggggcact ggggaacctg acactggtgc tagccatcat cgtgttcatc tttgctgtgg     2760

tgggcatgca gctctttggc aagaactact cggagctgag ggacagcgac tcaggcctgc     2820

tgcctcgctg gcacatgatg gacttctttc atgccttcct catcatcttc cgcatcctct     2880

gtggagagtg gatcgagacc atgtgggact gcatggaggt gtcggggcag tcattatgcc     2940

tgctggtctt cttgcttgtt atggtcattg gcaaccttgt ggtcctgaat ctcttcctgg     3000

ccttgctgct cagctccttc agtgcagaca acctcacagc ccctgatgag gacagagaga     3060

tgaacaacct ccagctggcc ctggcccgca tccagagggg cctgcgcttt gtcaagcgga     3120

ccacctggga tttctgctgt ggtctcctgc ggcagcggcc tcagaagccc gcagcccttg     3180

ccgcccaggg ccagctgccc agctgcattg ccacccccta ctccccgcca cccccagaga     3240

cggagaaggt gcctcccacc cgcaaggaaa cacggtttga ggaaggcgag caaccaggcc     3300

agggcacccc cggggatcca gagcccgtgt gtgtgcccat cgctgtggcc gagtcagaca     3360

cagatgacca agaagaagat gaggagaaca gcctgggcac ggaggaggag tccagcaagc     3420

agcaggaatc ccagcctgtg tccggtggcc cagaggcccc tccggattcc aggacctgga     3480

gccaggtgtc agcgactgcc tcctctgagg ccgaggccag tgcatctcag gccgactggc     3540

ggcagcagtg gaaagcggaa ccccaggccc cagggtgcgg tgagacccca gaggacagtt     3600

gctccgaggg cagcacagca gacatgacca acaccgctga gctcctggag cagatccctg     3660

acctcggcca ggatgtcaag gacccagagg actgcttcac tgaaggctgt gtccggcgct     3720

gtccctgctg tgcggtggac accacacagg ccccagggaa ggtctggtgg cggttgcgca     3780

agacctgcta ccacatcgtg gagcacagct ggttcgagac attcatcatc ttcatgatcc     3840

tactcagcag tggagcgctg gccttcgagg acatctacct agaggagcgg aagaccatca     3900

aggttctgct tgagtatgcc gacaagatgt tcacatatgt cttcgtgctg gagatgctgc     3960

tcaagtgggt ggcctacggc ttcaagaagt acttcaccaa tgcctggtgc tggctcgact     4020

tcctcatcgt agacgtctct ctggtcagcc tggtggccaa caccctgggc tttgccgaga     4080

tgggccccat caagtcactg cggacgctgc gtgcactccg tcctctgaga gctctgtcac     4140

gatttgaggg catgagggtg gtggtcaatg ccctggtggg cgccatcccg tccatcatga     4200

acgtcctcct cgtctgcctc atcttctggc tcatcttcag catcatgggc gtgaacctct     4260

ttgcggggaa gtttgggagg tgcatcaacc agacagaggg agacttgcct ttgaactaca     4320

ccatcgtgaa caacaagagc cagtgtgagt ccttgaactt gaccggagaa ttgtactgga     4380

ccaaggtgaa agtcaacttt gacaacgtgg gggccgggta cctggccctt ctgcaggtgg     4440

caacatttaa aggctggatg gacattatgt atgcagctgt ggactccagg gggtatgaag     4500

agcagcctca gtgggaatac aacctctaca tgtacatcta ttttgtcatt ttcatcatct     4560

ttgggtcttt cttcaccctg aacctcttta ttggtgtcat cattgacaac ttcaaccaac     4620

agaagaaaaa gttagggggc caggacatct tcatgacaga ggagcagaag aagtactaca     4680

atgccatgaa gaagctgggc tccaagaagc cccagaagcc catcccacgg cccctgaaca     4740

agtaccaggg cttcatattc gacattgtga ccaagcaggc ctttgacgtc accatcatgt     4800

ttctgatctg cttgaatatg gtgaccatga tggtggagac agatgaccaa agtcctgaga     4860

aaatcaacat cttggccaag atcaacctgc tctttgtggc catcttcaca ggcgagtgta     4920

ttgtcaagct ggctgccctg cgccactact acttcaccaa cagctggaat atcttcgact     4980

tcgtggttgt catcctctcc atcgtggaac tgcacaatga ccagcaggag gggagaagag     5040

agtaggaaaa aggagggaag gacagacatc aagtgccaga tgttgtctga actaatcgag     5100

cacttctcac caaacttcat gtataaataa aatacatatt tttaaaacaa accaataaat     5160

ggcttacatg                                                            5170


<210>  9
<211>  1616
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser Phe Arg Arg Phe 
1               5                   10                  15      


Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met Ala Glu Lys Gln 
            20                  25                  30          


Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu Gly Leu Pro Glu 
        35                  40                  45              


Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala Ser Lys Lys Leu 
    50                  55                  60                  


Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile Gly Glu Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr Asn Ala Leu Tyr 
            100                 105                 110         


Val Leu Ser Pro Phe His Pro Ile Arg Arg Ala Ala Val Lys Ile Leu 
        115                 120                 125             


Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp Thr Lys Tyr Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Leu His Ala Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala Tyr Thr Thr Glu 
        195                 200                 205             


Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Ser Val Ile Ser Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp Val Met Val Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe Thr Ala Leu Asn 
        275                 280                 285             


Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val Trp Glu Ser Leu 
    290                 295                 300                 


Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu Lys Asn Gly Thr 
305                 310                 315                 320 


Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Thr Cys Pro 
                325                 330                 335     


Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro Asp His Gly Tyr 
            340                 345                 350         


Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala Leu Phe Arg Leu 
        355                 360                 365             


Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Ser 
    370                 375                 380                 


Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val Ile Phe Leu Gly 
385                 390                 395                 400 


Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr 
                405                 410                 415     


Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr Glu Glu Lys Glu Lys 
            420                 425                 430         


Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys Glu His Glu Ala Leu 
        435                 440                 445             


Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser Ser Leu Glu Met Ser 
    450                 455                 460                 


Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg Ser Lys Arg Arg Lys 
465                 470                 475                 480 


Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu Asp Arg Leu Pro Lys 
                485                 490                 495     


Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn His Leu Ser Leu Thr 
            500                 505                 510         


Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg Ser Ser Arg Gly Ser 
        515                 520                 525             


Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser Glu Ala Asp Phe Ala 
    530                 535                 540                 


Asp Asp Glu Asn Ser Thr Ala Gly Glu Ser Glu Ser His His Thr Ser 
545                 550                 555                 560 


Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser Ala Gln Gly Gln Pro 
                565                 570                 575     


Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu His Gly Lys Lys Asn 
            580                 585                 590         


Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Leu Gly Ala Gly Asp 
        595                 600                 605             


Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu Arg Pro Val Met Leu 
    610                 615                 620                 


Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu Glu Pro Gly Gly Pro 
625                 630                 635                 640 


Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp Gly Phe Glu Glu Pro 
                645                 650                 655     


Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser Val Leu Thr Ser Ala 
            660                 665                 670         


Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys Pro Pro Cys Trp Asn 
        675                 680                 685             


Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys Cys Pro Leu Trp Met 
    690                 695                 700                 


Ser Ile Lys Gln Gly Val Lys Leu Val Val Met Asp Pro Phe Thr Asp 
705                 710                 715                 720 


Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr Leu Phe Met Ala Leu 
                725                 730                 735     


Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met Leu Gln Val Gly 
            740                 745                 750         


Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Thr Phe Lys Ile 
        755                 760                 765             


Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln Gly Trp Asn Ile Phe 
    770                 775                 780                 


Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu Leu Gly Leu Ser Arg 
785                 790                 795                 800 


Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
                805                 810                 815     


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile 
            820                 825                 830         


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
        835                 840                 845             


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Asn 
    850                 855                 860                 


Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu Leu Pro Arg Trp His 
865                 870                 875                 880 


Met Met Asp Phe Phe His Ala Phe Leu Ile Ile Phe Arg Ile Leu Cys 
                885                 890                 895     


Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ser Gly Gln 
            900                 905                 910         


Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met Val Ile Gly Asn Leu 
        915                 920                 925             


Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ala 
    930                 935                 940                 


Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu Met Asn Asn Leu Gln 
945                 950                 955                 960 


Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg Phe Val Lys Arg Thr 
                965                 970                 975     


Thr Trp Asp Phe Cys Cys Gly Leu Leu Arg Gln Arg Pro Gln Lys Pro 
            980                 985                 990         


Ala Ala Leu Ala Ala Gln Gly Gln  Leu Pro Ser Cys Ile  Ala Thr Pro 
        995                 1000                 1005             


Tyr Ser  Pro Pro Pro Pro Glu  Thr Glu Lys Val Pro  Pro Thr Arg 
    1010                 1015                 1020             


Lys Glu  Thr Arg Phe Glu Glu  Gly Glu Gln Pro Gly  Gln Gly Thr 
    1025                 1030                 1035             


Pro Gly  Asp Pro Glu Pro Val  Cys Val Pro Ile Ala  Val Ala Glu 
    1040                 1045                 1050             


Ser Asp  Thr Asp Asp Gln Glu  Glu Asp Glu Glu Asn  Ser Leu Gly 
    1055                 1060                 1065             


Thr Glu  Glu Glu Ser Ser Lys  Gln Gln Glu Ser Gln  Pro Val Ser 
    1070                 1075                 1080             


Gly Gly  Pro Glu Ala Pro Pro  Asp Ser Arg Thr Trp  Ser Gln Val 
    1085                 1090                 1095             


Ser Ala  Thr Ala Ser Ser Glu  Ala Glu Ala Ser Ala  Ser Gln Ala 
    1100                 1105                 1110             


Asp Trp  Arg Gln Gln Trp Lys  Ala Glu Pro Gln Ala  Pro Gly Cys 
    1115                 1120                 1125             


Gly Glu  Thr Pro Glu Asp Ser  Cys Ser Glu Gly Ser  Thr Ala Asp 
    1130                 1135                 1140             


Met Thr  Asn Thr Ala Glu Leu  Leu Glu Gln Ile Pro  Asp Leu Gly 
    1145                 1150                 1155             


Gln Asp  Val Lys Asp Pro Glu  Asp Cys Phe Thr Glu  Gly Cys Val 
    1160                 1165                 1170             


Arg Arg  Cys Pro Cys Cys Ala  Val Asp Thr Thr Gln  Ala Pro Gly 
    1175                 1180                 1185             


Lys Val  Trp Trp Arg Leu Arg  Lys Thr Cys Tyr His  Ile Val Glu 
    1190                 1195                 1200             


His Ser  Trp Phe Glu Thr Phe  Ile Ile Phe Met Ile  Leu Leu Ser 
    1205                 1210                 1215             


Ser Gly  Ala Leu Ala Phe Glu  Asp Ile Tyr Leu Glu  Glu Arg Lys 
    1220                 1225                 1230             


Thr Ile  Lys Val Leu Leu Glu  Tyr Ala Asp Lys Met  Phe Thr Tyr 
    1235                 1240                 1245             


Val Phe  Val Leu Glu Met Leu  Leu Lys Trp Val Ala  Tyr Gly Phe 
    1250                 1255                 1260             


Lys Lys  Tyr Phe Thr Asn Ala  Trp Cys Trp Leu Asp  Phe Leu Ile 
    1265                 1270                 1275             


Val Asp  Val Ser Leu Val Ser  Leu Val Ala Asn Thr  Leu Gly Phe 
    1280                 1285                 1290             


Ala Glu  Met Gly Pro Ile Lys  Ser Leu Arg Thr Leu  Arg Ala Leu 
    1295                 1300                 1305             


Arg Pro  Leu Arg Ala Leu Ser  Arg Phe Glu Gly Met  Arg Val Val 
    1310                 1315                 1320             


Val Asn  Ala Leu Val Gly Ala  Ile Pro Ser Ile Met  Asn Val Leu 
    1325                 1330                 1335             


Leu Val  Cys Leu Ile Phe Trp  Leu Ile Phe Ser Ile  Met Gly Val 
    1340                 1345                 1350             


Asn Leu  Phe Ala Gly Lys Phe  Gly Arg Cys Ile Asn  Gln Thr Glu 
    1355                 1360                 1365             


Gly Asp  Leu Pro Leu Asn Tyr  Thr Ile Val Asn Asn  Lys Ser Gln 
    1370                 1375                 1380             


Cys Glu  Ser Leu Asn Leu Thr  Gly Glu Leu Tyr Trp  Thr Lys Val 
    1385                 1390                 1395             


Lys Val  Asn Phe Asp Asn Val  Gly Ala Gly Tyr Leu  Ala Leu Leu 
    1400                 1405                 1410             


Gln Val  Ala Thr Phe Lys Gly  Trp Met Asp Ile Met  Tyr Ala Ala 
    1415                 1420                 1425             


Val Asp  Ser Arg Gly Tyr Glu  Glu Gln Pro Gln Trp  Glu Tyr Asn 
    1430                 1435                 1440             


Leu Tyr  Met Tyr Ile Tyr Phe  Val Ile Phe Ile Ile  Phe Gly Ser 
    1445                 1450                 1455             


Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val Ile Ile  Asp Asn Phe 
    1460                 1465                 1470             


Asn Gln  Gln Lys Lys Lys Leu  Gly Gly Gln Asp Ile  Phe Met Thr 
    1475                 1480                 1485             


Glu Glu  Gln Lys Lys Tyr Tyr  Asn Ala Met Lys Lys  Leu Gly Ser 
    1490                 1495                 1500             


Lys Lys  Pro Gln Lys Pro Ile  Pro Arg Pro Leu Asn  Lys Tyr Gln 
    1505                 1510                 1515             


Gly Phe  Ile Phe Asp Ile Val  Thr Lys Gln Ala Phe  Asp Val Thr 
    1520                 1525                 1530             


Ile Met  Phe Leu Ile Cys Leu  Asn Met Val Thr Met  Met Val Glu 
    1535                 1540                 1545             


Thr Asp  Asp Gln Ser Pro Glu  Lys Ile Asn Ile Leu  Ala Lys Ile 
    1550                 1555                 1560             


Asn Leu  Leu Phe Val Ala Ile  Phe Thr Gly Glu Cys  Ile Val Lys 
    1565                 1570                 1575             


Leu Ala  Ala Leu Arg His Tyr  Tyr Phe Thr Asn Ser  Trp Asn Ile 
    1580                 1585                 1590             


Phe Asp  Phe Val Val Val Ile  Leu Ser Ile Val Glu  Leu His Asn 
    1595                 1600                 1605             


Asp Gln  Gln Glu Gly Arg Arg  Glu 
    1610                 1615     


<210>  10
<211>  5120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E28D Splice Variant cDNA Sequence

<400>  10
agacggcggc ggcgcccgta ggatgcaggg atcgctcccc cggggccgct gagcctgcgc       60

ccagtgcccc gagccccgcg ccgagccgag tccgcgccaa gcagcagccg cccaccccgg      120

ggcccggccg ggggaccagc agcttcccca caggcaacgt gaggagagcc tgtgcccaga      180

agcaggatga gaagatggca aacttcctat tacctcgggg caccagcagc ttccgcaggt      240

tcacacggga gtccctggca gccatcgaga agcgcatggc agagaagcaa gcccgcggct      300

caaccacctt gcaggagagc cgagaggggc tgcccgagga ggaggctccc cggccccagc      360

tggacctgca ggcctccaaa aagctgccag atctctatgg caatccaccc caagagctca      420

tcggagagcc cctggaggac ctggacccct tctatagcac ccaaaagact ttcatcgtac      480

tgaataaagg caagaccatc ttccggttca gtgccaccaa cgccttgtat gtcctcagtc      540

ccttccaccc catccggaga gcggctgtga agattctggt tcactcgctc ttcaacatgc      600

tcatcatgtg caccatcctc accaactgcg tgttcatggc ccagcacgac cctccaccct      660

ggaccaagta tgtcgagtac accttcaccg ccatttacac ctttgagtct ctggtcaaga      720

ttctggctcg aggcttctgc ctgcacgcgt tcactttcct tcgggaccca tggaactggc      780

tggactttag tgtgattatc atggcataca caactgaatt tgtggacctg ggcaatgtct      840

cagccttacg caccttccga gtcctccggg ccctgaaaac tatatcagtc atttcagggc      900

tgaagaccat cgtgggggcc ctgatccagt ctgtgaagaa gctggctgat gtgatggtcc      960

tcacagtctt ctgcctcagc gtctttgccc tcatcggcct gcagctcttc atgggcaacc     1020

taaggcacaa gtgcgtgcgc aacttcacag cgctcaacgg caccaacggc tccgtggagg     1080

ccgacggctt ggtctgggaa tccctggacc tttacctcag tgatccagaa aattacctgc     1140

tcaagaacgg cacctctgat gtgttactgt gtgggaacag ctctgacgct gggacatgtc     1200

cggagggcta ccggtgccta aaggcaggcg agaaccccga ccacggctac accagcttcg     1260

attcctttgc ctgggccttt cttgcactct tccgcctgat gacgcaggac tgctgggagc     1320

gcctctatca gcagaccctc aggtccgcag ggaagatcta catgatcttc ttcatgcttg     1380

tcatcttcct ggggtccttc tacctggtga acctgatcct ggccgtggtc gcaatggcct     1440

atgaggagca aaaccaagcc accatcgctg agaccgagga gaaggaaaag cgcttccagg     1500

aggccatgga aatgctcaag aaagaacacg aggccctcac catcaggggt gtggataccg     1560

tgtcccgtag ctccttggag atgtcccctt tggccccagt aaacagccat gagagaagaa     1620

gcaagaggag aaaacggatg tcttcaggaa ctgaggagtg tggggaggac aggctcccca     1680

agtctgactc agaagatggt cccagagcaa tgaatcatct cagcctcacc cgtggcctca     1740

gcaggacttc tatgaagcca cgttccagcc gcgggagcat tttcaccttt cgcaggcgag     1800

acctgggttc tgaagcagat tttgcagatg atgaaaacag cacagcgggg gagagcgaga     1860

gccaccacac atcactgctg gtgccctggc ccctgcgccg gaccagtgcc cagggacagc     1920

ccagtcccgg aacctcggct cctggccacg ccctccatgg caaaaagaac agcactgtgg     1980

actgcaatgg ggtggtctca ttactggggg caggcgaccc agaggccaca tccccaggaa     2040

gccacctcct ccgccctgtg atgctagagc acccgccaga cacgaccacg ccatcggagg     2100

agccaggcgg gccccagatg ctgacctccc aggctccgtg tgtagatggc ttcgaggagc     2160

caggagcacg gcagcgggcc ctcagcgcag tcagcgtcct caccagcgca ctggaagagt     2220

tagaggagtc tcgccacaag tgtccaccat gctggaaccg tctcgcccag cgctacctga     2280

tctgggagtg ctgcccgctg tggatgtcca tcaagcaggg agtgaagttg gtggtcatgg     2340

acccgtttac tgacctcacc atcactatgt gcatcgtact caacacactc ttcatggcgc     2400

tggagcacta caacatgaca agtgaattcg aggagatgct gcaggtcgga aacctggtct     2460

tcacagggat tttcacagca gagatgacct tcaagatcat tgccctcgac ccctactact     2520

acttccaaca gggctggaac atcttcgaca gcatcatcgt catccttagc ctcatggagc     2580

tgggcctgtc ccgcatgagc aacttgtcgg tgctgcgctc cttccgcctg ctgcgggtct     2640

tcaagctggc caaatcatgg cccaccctga acacactcat caagatcatc gggaactcag     2700

tgggggcact ggggaacctg acactggtgc tagccatcat cgtgttcatc tttgctgtgg     2760

tgggcatgca gctctttggc aagaactact cggagctgag ggacagcgac tcaggcctgc     2820

tgcctcgctg gcacatgatg gacttctttc atgccttcct catcatcttc cgcatcctct     2880

gtggagagtg gatcgagacc atgtgggact gcatggaggt gtcggggcag tcattatgcc     2940

tgctggtctt cttgcttgtt atggtcattg gcaaccttgt ggtcctgaat ctcttcctgg     3000

ccttgctgct cagctccttc agtgcagaca acctcacagc ccctgatgag gacagagaga     3060

tgaacaacct ccagctggcc ctggcccgca tccagagggg cctgcgcttt gtcaagcgga     3120

ccacctggga tttctgctgt ggtctcctgc ggcagcggcc tcagaagccc gcagcccttg     3180

ccgcccaggg ccagctgccc agctgcattg ccacccccta ctccccgcca cccccagaga     3240

cggagaaggt gcctcccacc cgcaaggaaa cacggtttga ggaaggcgag caaccaggcc     3300

agggcacccc cggggatcca gagcccgtgt gtgtgcccat cgctgtggcc gagtcagaca     3360

cagatgacca agaagaagat gaggagaaca gcctgggcac ggaggaggag tccagcaagc     3420

agcaggaatc ccagcctgtg tccggtggcc cagaggcccc tccggattcc aggacctgga     3480

gccaggtgtc agcgactgcc tcctctgagg ccgaggccag tgcatctcag gccgactggc     3540

ggcagcagtg gaaagcggaa ccccaggccc cagggtgcgg tgagacccca gaggacagtt     3600

gctccgaggg cagcacagca gacatgacca acaccgctga gctcctggag cagatccctg     3660

acctcggcca ggatgtcaag gacccagagg actgcttcac tgaaggctgt gtccggcgct     3720

gtccctgctg tgcggtggac accacacagg ccccagggaa ggtctggtgg cggttgcgca     3780

agacctgcta ccacatcgtg gagcacagct ggttcgagac attcatcatc ttcatgatcc     3840

tactcagcag tggagcgctg gccttcgagg acatctacct agaggagcgg aagaccatca     3900

aggttctgct tgagtatgcc gacaagatgt tcacatatgt cttcgtgctg gagatgctgc     3960

tcaagtgggt ggcctacggc ttcaagaagt acttcaccaa tgcctggtgc tggctcgact     4020

tcctcatcgt agacgtctct ctggtcagcc tggtggccaa caccctgggc tttgccgaga     4080

tgggccccat caagtcactg cggacgctgc gtgcactccg tcctctgaga gctctgtcac     4140

gatttgaggg catgagggtg gtggtcaatg ccctggtggg cgccatcccg tccatcatga     4200

acgtcctcct cgtctgcctc atcttctggc tcatcttcag catcatgggc gtgaacctct     4260

ttgcggggaa gtttgggagg tgcatcaacc agacagaggg agacttgcct ttgaactaca     4320

ccatcgtgaa caacaagagc cagtgtgagt ccttgaactt gaccggagaa ttgtactgga     4380

ccaaggtgaa agtcaacttt gacaacgtgg gggccgggta cctggccctt ctgcaggtgg     4440

caacatttaa aggctggatg gacattatgt atgcagctgt ggactccagg gggtatgaag     4500

agcagcctca gtgggaatac aacctctaca tgtacatcta ttttgtcatt ttcatcatct     4560

ttgggtcttt cttcaccctg aacctcttta ttggtgtcat cattgacaac ttcaaccaac     4620

agaagaaaaa gttagggggc caggacatct tcatgacaga ggagcagaag aagtactaca     4680

atgccatgaa gaagctgggc tccaagaagc cccagaagcc catcccacgg cccctgaaca     4740

agtaccaggg cttcatattc gacattgtga ccaagcaggc ctttgacgtc accatcatgt     4800

ttctgatctg cttgaatatg gtgaccatga tggtggagac agatgaccaa agtcctgaga     4860

aaatcaacat cttggccaag atcaacctgc tctttgtggc catcttcaca ggcgagtgta     4920

ttgtcaagct ggctgccctg cgccactact acttcaccaa cagctggaat atcttcgact     4980

tcgtggttgt catcctctcc atcgtgggca ctgtgctctc ggacatcatc cagaagtact     5040

tcttctcccc gacgctcttc cgagtcatcc gcctggcccg aataggccgc atcctcagac     5100

tgatccgagg ggccaagggg                                                 5120


<210>  11
<211>  1642
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser Phe Arg Arg Phe 
1               5                   10                  15      


Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met Ala Glu Lys Gln 
            20                  25                  30          


Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu Gly Leu Pro Glu 
        35                  40                  45              


Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala Ser Lys Lys Leu 
    50                  55                  60                  


Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile Gly Glu Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr Asn Ala Leu Tyr 
            100                 105                 110         


Val Leu Ser Pro Phe His Pro Ile Arg Arg Ala Ala Val Lys Ile Leu 
        115                 120                 125             


Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp Thr Lys Tyr Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Leu His Ala Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala Tyr Thr Thr Glu 
        195                 200                 205             


Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Ser Val Ile Ser Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp Val Met Val Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe Thr Ala Leu Asn 
        275                 280                 285             


Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val Trp Glu Ser Leu 
    290                 295                 300                 


Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu Lys Asn Gly Thr 
305                 310                 315                 320 


Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Thr Cys Pro 
                325                 330                 335     


Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro Asp His Gly Tyr 
            340                 345                 350         


Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala Leu Phe Arg Leu 
        355                 360                 365             


Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Ser 
    370                 375                 380                 


Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val Ile Phe Leu Gly 
385                 390                 395                 400 


Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr 
                405                 410                 415     


Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr Glu Glu Lys Glu Lys 
            420                 425                 430         


Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys Glu His Glu Ala Leu 
        435                 440                 445             


Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser Ser Leu Glu Met Ser 
    450                 455                 460                 


Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg Ser Lys Arg Arg Lys 
465                 470                 475                 480 


Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu Asp Arg Leu Pro Lys 
                485                 490                 495     


Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn His Leu Ser Leu Thr 
            500                 505                 510         


Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg Ser Ser Arg Gly Ser 
        515                 520                 525             


Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser Glu Ala Asp Phe Ala 
    530                 535                 540                 


Asp Asp Glu Asn Ser Thr Ala Gly Glu Ser Glu Ser His His Thr Ser 
545                 550                 555                 560 


Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser Ala Gln Gly Gln Pro 
                565                 570                 575     


Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu His Gly Lys Lys Asn 
            580                 585                 590         


Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Leu Gly Ala Gly Asp 
        595                 600                 605             


Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu Arg Pro Val Met Leu 
    610                 615                 620                 


Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu Glu Pro Gly Gly Pro 
625                 630                 635                 640 


Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp Gly Phe Glu Glu Pro 
                645                 650                 655     


Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser Val Leu Thr Ser Ala 
            660                 665                 670         


Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys Pro Pro Cys Trp Asn 
        675                 680                 685             


Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys Cys Pro Leu Trp Met 
    690                 695                 700                 


Ser Ile Lys Gln Gly Val Lys Leu Val Val Met Asp Pro Phe Thr Asp 
705                 710                 715                 720 


Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr Leu Phe Met Ala Leu 
                725                 730                 735     


Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met Leu Gln Val Gly 
            740                 745                 750         


Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Thr Phe Lys Ile 
        755                 760                 765             


Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln Gly Trp Asn Ile Phe 
    770                 775                 780                 


Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu Leu Gly Leu Ser Arg 
785                 790                 795                 800 


Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
                805                 810                 815     


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile 
            820                 825                 830         


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
        835                 840                 845             


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Asn 
    850                 855                 860                 


Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu Leu Pro Arg Trp His 
865                 870                 875                 880 


Met Met Asp Phe Phe His Ala Phe Leu Ile Ile Phe Arg Ile Leu Cys 
                885                 890                 895     


Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ser Gly Gln 
            900                 905                 910         


Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met Val Ile Gly Asn Leu 
        915                 920                 925             


Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ala 
    930                 935                 940                 


Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu Met Asn Asn Leu Gln 
945                 950                 955                 960 


Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg Phe Val Lys Arg Thr 
                965                 970                 975     


Thr Trp Asp Phe Cys Cys Gly Leu Leu Arg Gln Arg Pro Gln Lys Pro 
            980                 985                 990         


Ala Ala Leu Ala Ala Gln Gly Gln  Leu Pro Ser Cys Ile  Ala Thr Pro 
        995                 1000                 1005             


Tyr Ser  Pro Pro Pro Pro Glu  Thr Glu Lys Val Pro  Pro Thr Arg 
    1010                 1015                 1020             


Lys Glu  Thr Arg Phe Glu Glu  Gly Glu Gln Pro Gly  Gln Gly Thr 
    1025                 1030                 1035             


Pro Gly  Asp Pro Glu Pro Val  Cys Val Pro Ile Ala  Val Ala Glu 
    1040                 1045                 1050             


Ser Asp  Thr Asp Asp Gln Glu  Glu Asp Glu Glu Asn  Ser Leu Gly 
    1055                 1060                 1065             


Thr Glu  Glu Glu Ser Ser Lys  Gln Gln Glu Ser Gln  Pro Val Ser 
    1070                 1075                 1080             


Gly Gly  Pro Glu Ala Pro Pro  Asp Ser Arg Thr Trp  Ser Gln Val 
    1085                 1090                 1095             


Ser Ala  Thr Ala Ser Ser Glu  Ala Glu Ala Ser Ala  Ser Gln Ala 
    1100                 1105                 1110             


Asp Trp  Arg Gln Gln Trp Lys  Ala Glu Pro Gln Ala  Pro Gly Cys 
    1115                 1120                 1125             


Gly Glu  Thr Pro Glu Asp Ser  Cys Ser Glu Gly Ser  Thr Ala Asp 
    1130                 1135                 1140             


Met Thr  Asn Thr Ala Glu Leu  Leu Glu Gln Ile Pro  Asp Leu Gly 
    1145                 1150                 1155             


Gln Asp  Val Lys Asp Pro Glu  Asp Cys Phe Thr Glu  Gly Cys Val 
    1160                 1165                 1170             


Arg Arg  Cys Pro Cys Cys Ala  Val Asp Thr Thr Gln  Ala Pro Gly 
    1175                 1180                 1185             


Lys Val  Trp Trp Arg Leu Arg  Lys Thr Cys Tyr His  Ile Val Glu 
    1190                 1195                 1200             


His Ser  Trp Phe Glu Thr Phe  Ile Ile Phe Met Ile  Leu Leu Ser 
    1205                 1210                 1215             


Ser Gly  Ala Leu Ala Phe Glu  Asp Ile Tyr Leu Glu  Glu Arg Lys 
    1220                 1225                 1230             


Thr Ile  Lys Val Leu Leu Glu  Tyr Ala Asp Lys Met  Phe Thr Tyr 
    1235                 1240                 1245             


Val Phe  Val Leu Glu Met Leu  Leu Lys Trp Val Ala  Tyr Gly Phe 
    1250                 1255                 1260             


Lys Lys  Tyr Phe Thr Asn Ala  Trp Cys Trp Leu Asp  Phe Leu Ile 
    1265                 1270                 1275             


Val Asp  Val Ser Leu Val Ser  Leu Val Ala Asn Thr  Leu Gly Phe 
    1280                 1285                 1290             


Ala Glu  Met Gly Pro Ile Lys  Ser Leu Arg Thr Leu  Arg Ala Leu 
    1295                 1300                 1305             


Arg Pro  Leu Arg Ala Leu Ser  Arg Phe Glu Gly Met  Arg Val Val 
    1310                 1315                 1320             


Val Asn  Ala Leu Val Gly Ala  Ile Pro Ser Ile Met  Asn Val Leu 
    1325                 1330                 1335             


Leu Val  Cys Leu Ile Phe Trp  Leu Ile Phe Ser Ile  Met Gly Val 
    1340                 1345                 1350             


Asn Leu  Phe Ala Gly Lys Phe  Gly Arg Cys Ile Asn  Gln Thr Glu 
    1355                 1360                 1365             


Gly Asp  Leu Pro Leu Asn Tyr  Thr Ile Val Asn Asn  Lys Ser Gln 
    1370                 1375                 1380             


Cys Glu  Ser Leu Asn Leu Thr  Gly Glu Leu Tyr Trp  Thr Lys Val 
    1385                 1390                 1395             


Lys Val  Asn Phe Asp Asn Val  Gly Ala Gly Tyr Leu  Ala Leu Leu 
    1400                 1405                 1410             


Gln Val  Ala Thr Phe Lys Gly  Trp Met Asp Ile Met  Tyr Ala Ala 
    1415                 1420                 1425             


Val Asp  Ser Arg Gly Tyr Glu  Glu Gln Pro Gln Trp  Glu Tyr Asn 
    1430                 1435                 1440             


Leu Tyr  Met Tyr Ile Tyr Phe  Val Ile Phe Ile Ile  Phe Gly Ser 
    1445                 1450                 1455             


Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val Ile Ile  Asp Asn Phe 
    1460                 1465                 1470             


Asn Gln  Gln Lys Lys Lys Leu  Gly Gly Gln Asp Ile  Phe Met Thr 
    1475                 1480                 1485             


Glu Glu  Gln Lys Lys Tyr Tyr  Asn Ala Met Lys Lys  Leu Gly Ser 
    1490                 1495                 1500             


Lys Lys  Pro Gln Lys Pro Ile  Pro Arg Pro Leu Asn  Lys Tyr Gln 
    1505                 1510                 1515             


Gly Phe  Ile Phe Asp Ile Val  Thr Lys Gln Ala Phe  Asp Val Thr 
    1520                 1525                 1530             


Ile Met  Phe Leu Ile Cys Leu  Asn Met Val Thr Met  Met Val Glu 
    1535                 1540                 1545             


Thr Asp  Asp Gln Ser Pro Glu  Lys Ile Asn Ile Leu  Ala Lys Ile 
    1550                 1555                 1560             


Asn Leu  Leu Phe Val Ala Ile  Phe Thr Gly Glu Cys  Ile Val Lys 
    1565                 1570                 1575             


Leu Ala  Ala Leu Arg His Tyr  Tyr Phe Thr Asn Ser  Trp Asn Ile 
    1580                 1585                 1590             


Phe Asp  Phe Val Val Val Ile  Leu Ser Ile Val Gly  Thr Val Leu 
    1595                 1600                 1605             


Ser Asp  Ile Ile Gln Lys Tyr  Phe Phe Ser Pro Thr  Leu Phe Arg 
    1610                 1615                 1620             


Val Ile  Arg Leu Ala Arg Ile  Gly Arg Ile Leu Arg  Leu Ile Arg 
    1625                 1630                 1635             


Gly Ala  Lys Gly 
    1640         


<210>  12
<211>  2016
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser Phe Arg Arg Phe 
1               5                   10                  15      


Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met Ala Glu Lys Gln 
            20                  25                  30          


Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu Gly Leu Pro Glu 
        35                  40                  45              


Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala Ser Lys Lys Leu 
    50                  55                  60                  


Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile Gly Glu Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr Asn Ala Leu Tyr 
            100                 105                 110         


Val Leu Ser Pro Phe His Pro Ile Arg Arg Ala Ala Val Lys Ile Leu 
        115                 120                 125             


Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp Thr Lys Tyr Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Leu His Ala Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala Tyr Thr Thr Glu 
        195                 200                 205             


Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Ser Val Ile Ser Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp Val Met Val Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe Thr Ala Leu Asn 
        275                 280                 285             


Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val Trp Glu Ser Leu 
    290                 295                 300                 


Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu Lys Asn Gly Thr 
305                 310                 315                 320 


Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Thr Cys Pro 
                325                 330                 335     


Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro Asp His Gly Tyr 
            340                 345                 350         


Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala Leu Phe Arg Leu 
        355                 360                 365             


Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Ser 
    370                 375                 380                 


Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val Ile Phe Leu Gly 
385                 390                 395                 400 


Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr 
                405                 410                 415     


Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr Glu Glu Lys Glu Lys 
            420                 425                 430         


Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys Glu His Glu Ala Leu 
        435                 440                 445             


Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser Ser Leu Glu Met Ser 
    450                 455                 460                 


Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg Ser Lys Arg Arg Lys 
465                 470                 475                 480 


Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu Asp Arg Leu Pro Lys 
                485                 490                 495     


Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn His Leu Ser Leu Thr 
            500                 505                 510         


Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg Ser Ser Arg Gly Ser 
        515                 520                 525             


Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser Glu Ala Asp Phe Ala 
    530                 535                 540                 


Asp Asp Glu Asn Ser Thr Ala Gly Glu Ser Glu Ser His His Thr Ser 
545                 550                 555                 560 


Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser Ala Gln Gly Gln Pro 
                565                 570                 575     


Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu His Gly Lys Lys Asn 
            580                 585                 590         


Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Leu Gly Ala Gly Asp 
        595                 600                 605             


Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu Arg Pro Val Met Leu 
    610                 615                 620                 


Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu Glu Pro Gly Gly Pro 
625                 630                 635                 640 


Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp Gly Phe Glu Glu Pro 
                645                 650                 655     


Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser Val Leu Thr Ser Ala 
            660                 665                 670         


Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys Pro Pro Cys Trp Asn 
        675                 680                 685             


Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys Cys Pro Leu Trp Met 
    690                 695                 700                 


Ser Ile Lys Gln Gly Val Lys Leu Val Val Met Asp Pro Phe Thr Asp 
705                 710                 715                 720 


Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr Leu Phe Met Ala Leu 
                725                 730                 735     


Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met Leu Gln Val Gly 
            740                 745                 750         


Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Thr Phe Lys Ile 
        755                 760                 765             


Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln Gly Trp Asn Ile Phe 
    770                 775                 780                 


Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu Leu Gly Leu Ser Arg 
785                 790                 795                 800 


Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
                805                 810                 815     


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile 
            820                 825                 830         


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
        835                 840                 845             


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Asn 
    850                 855                 860                 


Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu Leu Pro Arg Trp His 
865                 870                 875                 880 


Met Met Asp Phe Phe His Ala Phe Leu Ile Ile Phe Arg Ile Leu Cys 
                885                 890                 895     


Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ser Gly Gln 
            900                 905                 910         


Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met Val Ile Gly Asn Leu 
        915                 920                 925             


Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ala 
    930                 935                 940                 


Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu Met Asn Asn Leu Gln 
945                 950                 955                 960 


Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg Phe Val Lys Arg Thr 
                965                 970                 975     


Thr Trp Asp Phe Cys Cys Gly Leu Leu Arg Gln Arg Pro Gln Lys Pro 
            980                 985                 990         


Ala Ala Leu Ala Ala Gln Gly Gln  Leu Pro Ser Cys Ile  Ala Thr Pro 
        995                 1000                 1005             


Tyr Ser  Pro Pro Pro Pro Glu  Thr Glu Lys Val Pro  Pro Thr Arg 
    1010                 1015                 1020             


Lys Glu  Thr Arg Phe Glu Glu  Gly Glu Gln Pro Gly  Gln Gly Thr 
    1025                 1030                 1035             


Pro Gly  Asp Pro Glu Pro Val  Cys Val Pro Ile Ala  Val Ala Glu 
    1040                 1045                 1050             


Ser Asp  Thr Asp Asp Gln Glu  Glu Asp Glu Glu Asn  Ser Leu Gly 
    1055                 1060                 1065             


Thr Glu  Glu Glu Ser Ser Lys  Gln Gln Glu Ser Gln  Pro Val Ser 
    1070                 1075                 1080             


Gly Gly  Pro Glu Ala Pro Pro  Asp Ser Arg Thr Trp  Ser Gln Val 
    1085                 1090                 1095             


Ser Ala  Thr Ala Ser Ser Glu  Ala Glu Ala Ser Ala  Ser Gln Ala 
    1100                 1105                 1110             


Asp Trp  Arg Gln Gln Trp Lys  Ala Glu Pro Gln Ala  Pro Gly Cys 
    1115                 1120                 1125             


Gly Glu  Thr Pro Glu Asp Ser  Cys Ser Glu Gly Ser  Thr Ala Asp 
    1130                 1135                 1140             


Met Thr  Asn Thr Ala Glu Leu  Leu Glu Gln Ile Pro  Asp Leu Gly 
    1145                 1150                 1155             


Gln Asp  Val Lys Asp Pro Glu  Asp Cys Phe Thr Glu  Gly Cys Val 
    1160                 1165                 1170             


Arg Arg  Cys Pro Cys Cys Ala  Val Asp Thr Thr Gln  Ala Pro Gly 
    1175                 1180                 1185             


Lys Val  Trp Trp Arg Leu Arg  Lys Thr Cys Tyr His  Ile Val Glu 
    1190                 1195                 1200             


His Ser  Trp Phe Glu Thr Phe  Ile Ile Phe Met Ile  Leu Leu Ser 
    1205                 1210                 1215             


Ser Gly  Ala Leu Ala Phe Glu  Asp Ile Tyr Leu Glu  Glu Arg Lys 
    1220                 1225                 1230             


Thr Ile  Lys Val Leu Leu Glu  Tyr Ala Asp Lys Met  Phe Thr Tyr 
    1235                 1240                 1245             


Val Phe  Val Leu Glu Met Leu  Leu Lys Trp Val Ala  Tyr Gly Phe 
    1250                 1255                 1260             


Lys Lys  Tyr Phe Thr Asn Ala  Trp Cys Trp Leu Asp  Phe Leu Ile 
    1265                 1270                 1275             


Val Asp  Val Ser Leu Val Ser  Leu Val Ala Asn Thr  Leu Gly Phe 
    1280                 1285                 1290             


Ala Glu  Met Gly Pro Ile Lys  Ser Leu Arg Thr Leu  Arg Ala Leu 
    1295                 1300                 1305             


Arg Pro  Leu Arg Ala Leu Ser  Arg Phe Glu Gly Met  Arg Val Val 
    1310                 1315                 1320             


Val Asn  Ala Leu Val Gly Ala  Ile Pro Ser Ile Met  Asn Val Leu 
    1325                 1330                 1335             


Leu Val  Cys Leu Ile Phe Trp  Leu Ile Phe Ser Ile  Met Gly Val 
    1340                 1345                 1350             


Asn Leu  Phe Ala Gly Lys Phe  Gly Arg Cys Ile Asn  Gln Thr Glu 
    1355                 1360                 1365             


Gly Asp  Leu Pro Leu Asn Tyr  Thr Ile Val Asn Asn  Lys Ser Gln 
    1370                 1375                 1380             


Cys Glu  Ser Leu Asn Leu Thr  Gly Glu Leu Tyr Trp  Thr Lys Val 
    1385                 1390                 1395             


Lys Val  Asn Phe Asp Asn Val  Gly Ala Gly Tyr Leu  Ala Leu Leu 
    1400                 1405                 1410             


Gln Val  Ala Thr Phe Lys Gly  Trp Met Asp Ile Met  Tyr Ala Ala 
    1415                 1420                 1425             


Val Asp  Ser Arg Gly Tyr Glu  Glu Gln Pro Gln Trp  Glu Tyr Asn 
    1430                 1435                 1440             


Leu Tyr  Met Tyr Ile Tyr Phe  Val Ile Phe Ile Ile  Phe Gly Ser 
    1445                 1450                 1455             


Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val Ile Ile  Asp Asn Phe 
    1460                 1465                 1470             


Asn Gln  Gln Lys Lys Lys Leu  Gly Gly Gln Asp Ile  Phe Met Thr 
    1475                 1480                 1485             


Glu Glu  Gln Lys Lys Tyr Tyr  Asn Ala Met Lys Lys  Leu Gly Ser 
    1490                 1495                 1500             


Lys Lys  Pro Gln Lys Pro Ile  Pro Arg Pro Leu Asn  Lys Tyr Gln 
    1505                 1510                 1515             


Gly Phe  Ile Phe Asp Ile Val  Thr Lys Gln Ala Phe  Asp Val Thr 
    1520                 1525                 1530             


Ile Met  Phe Leu Ile Cys Leu  Asn Met Val Thr Met  Met Val Glu 
    1535                 1540                 1545             


Thr Asp  Asp Gln Ser Pro Glu  Lys Ile Asn Ile Leu  Ala Lys Ile 
    1550                 1555                 1560             


Asn Leu  Leu Phe Val Ala Ile  Phe Thr Gly Glu Cys  Ile Val Lys 
    1565                 1570                 1575             


Leu Ala  Ala Leu Arg His Tyr  Tyr Phe Thr Asn Ser  Trp Asn Ile 
    1580                 1585                 1590             


Phe Asp  Phe Val Val Val Ile  Leu Ser Ile Val Gly  Thr Val Leu 
    1595                 1600                 1605             


Ser Asp  Ile Ile Gln Lys Tyr  Phe Phe Ser Pro Thr  Leu Phe Arg 
    1610                 1615                 1620             


Val Ile  Arg Leu Ala Arg Ile  Gly Arg Ile Leu Arg  Leu Ile Arg 
    1625                 1630                 1635             


Gly Ala  Lys Gly Ile Arg Thr  Leu Leu Phe Ala Leu  Met Met Ser 
    1640                 1645                 1650             


Leu Pro  Ala Leu Phe Asn Ile  Gly Leu Leu Leu Phe  Leu Val Met 
    1655                 1660                 1665             


Phe Ile  Tyr Ser Ile Phe Gly  Met Ala Asn Phe Ala  Tyr Val Lys 
    1670                 1675                 1680             


Trp Glu  Ala Gly Ile Asp Asp  Met Phe Asn Phe Gln  Thr Phe Ala 
    1685                 1690                 1695             


Asn Ser  Met Leu Cys Leu Phe  Gln Ile Thr Thr Ser  Ala Gly Trp 
    1700                 1705                 1710             


Asp Gly  Leu Leu Ser Pro Ile  Leu Asn Thr Gly Pro  Pro Tyr Cys 
    1715                 1720                 1725             


Asp Pro  Thr Leu Pro Asn Ser  Asn Gly Ser Arg Gly  Asp Cys Gly 
    1730                 1735                 1740             


Ser Pro  Ala Val Gly Ile Leu  Phe Phe Thr Thr Tyr  Ile Ile Ile 
    1745                 1750                 1755             


Ser Phe  Leu Ile Val Val Asn  Met Tyr Ile Ala Ile  Ile Leu Glu 
    1760                 1765                 1770             


Asn Phe  Ser Val Ala Thr Glu  Glu Ser Thr Glu Pro  Leu Ser Glu 
    1775                 1780                 1785             


Asp Asp  Phe Asp Met Phe Tyr  Glu Ile Trp Glu Lys  Phe Asp Pro 
    1790                 1795                 1800             


Glu Ala  Thr Gln Phe Ile Glu  Tyr Ser Val Leu Ser  Asp Phe Ala 
    1805                 1810                 1815             


Asp Ala  Leu Ser Glu Pro Leu  Arg Ile Ala Lys Pro  Asn Gln Ile 
    1820                 1825                 1830             


Ser Leu  Ile Asn Met Asp Leu  Pro Met Val Ser Gly  Asp Arg Ile 
    1835                 1840                 1845             


His Cys  Met Asp Ile Leu Phe  Ala Phe Thr Lys Arg  Val Leu Gly 
    1850                 1855                 1860             


Glu Ser  Gly Glu Met Asp Ala  Leu Lys Ile Gln Met  Glu Glu Lys 
    1865                 1870                 1875             


Phe Met  Ala Ala Asn Pro Ser  Lys Ile Ser Tyr Glu  Pro Ile Thr 
    1880                 1885                 1890             


Thr Thr  Leu Arg Arg Lys His  Glu Glu Val Ser Ala  Met Val Ile 
    1895                 1900                 1905             


Gln Arg  Ala Phe Arg Arg His  Leu Leu Gln Arg Ser  Leu Lys His 
    1910                 1915                 1920             


Ala Ser  Phe Leu Phe Arg Gln  Gln Ala Gly Ser Gly  Leu Ser Glu 
    1925                 1930                 1935             


Glu Asp  Ala Pro Glu Arg Glu  Gly Leu Ile Ala Tyr  Val Met Ser 
    1940                 1945                 1950             


Glu Asn  Phe Ser Arg Pro Leu  Gly Pro Pro Ser Ser  Ser Ser Ile 
    1955                 1960                 1965             


Ser Ser  Thr Ser Phe Pro Pro  Ser Tyr Asp Ser Val  Thr Arg Ala 
    1970                 1975                 1980             


Thr Ser  Asp Asn Leu Gln Val  Arg Gly Ser Asp Tyr  Ser His Ser 
    1985                 1990                 1995             


Glu Asp  Leu Ala Asp Phe Pro  Pro Ser Pro Asp Arg  Asp Arg Glu 
    2000                 2005                 2010             


Ser Ile  Val 
    2015     


<210>  13
<211>  8504
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SCN5A cDNA sequence

<400>  13
agacggcggc ggcgcccgta ggatgcaggg atcgctcccc cggggccgct gagcctgcgc       60

ccagtgcccc gagccccgcg ccgagccgag tccgcgccaa gcagcagccg cccaccccgg      120

ggcccggccg ggggaccagc agcttcccca caggcaacgt gaggagagcc tgtgcccaga      180

agcaggatga gaagatggca aacttcctat tacctcgggg caccagcagc ttccgcaggt      240

tcacacggga gtccctggca gccatcgaga agcgcatggc agagaagcaa gcccgcggct      300

caaccacctt gcaggagagc cgagaggggc tgcccgagga ggaggctccc cggccccagc      360

tggacctgca ggcctccaaa aagctgccag atctctatgg caatccaccc caagagctca      420

tcggagagcc cctggaggac ctggacccct tctatagcac ccaaaagact ttcatcgtac      480

tgaataaagg caagaccatc ttccggttca gtgccaccaa cgccttgtat gtcctcagtc      540

ccttccaccc catccggaga gcggctgtga agattctggt tcactcgctc ttcaacatgc      600

tcatcatgtg caccatcctc accaactgcg tgttcatggc ccagcacgac cctccaccct      660

ggaccaagta tgtcgagtac accttcaccg ccatttacac ctttgagtct ctggtcaaga      720

ttctggctcg aggcttctgc ctgcacgcgt tcactttcct tcgggaccca tggaactggc      780

tggactttag tgtgattatc atggcataca caactgaatt tgtggacctg ggcaatgtct      840

cagccttacg caccttccga gtcctccggg ccctgaaaac tatatcagtc atttcagggc      900

tgaagaccat cgtgggggcc ctgatccagt ctgtgaagaa gctggctgat gtgatggtcc      960

tcacagtctt ctgcctcagc gtctttgccc tcatcggcct gcagctcttc atgggcaacc     1020

taaggcacaa gtgcgtgcgc aacttcacag cgctcaacgg caccaacggc tccgtggagg     1080

ccgacggctt ggtctgggaa tccctggacc tttacctcag tgatccagaa aattacctgc     1140

tcaagaacgg cacctctgat gtgttactgt gtgggaacag ctctgacgct gggacatgtc     1200

cggagggcta ccggtgccta aaggcaggcg agaaccccga ccacggctac accagcttcg     1260

attcctttgc ctgggccttt cttgcactct tccgcctgat gacgcaggac tgctgggagc     1320

gcctctatca gcagaccctc aggtccgcag ggaagatcta catgatcttc ttcatgcttg     1380

tcatcttcct ggggtccttc tacctggtga acctgatcct ggccgtggtc gcaatggcct     1440

atgaggagca aaaccaagcc accatcgctg agaccgagga gaaggaaaag cgcttccagg     1500

aggccatgga aatgctcaag aaagaacacg aggccctcac catcaggggt gtggataccg     1560

tgtcccgtag ctccttggag atgtcccctt tggccccagt aaacagccat gagagaagaa     1620

gcaagaggag aaaacggatg tcttcaggaa ctgaggagtg tggggaggac aggctcccca     1680

agtctgactc agaagatggt cccagagcaa tgaatcatct cagcctcacc cgtggcctca     1740

gcaggacttc tatgaagcca cgttccagcc gcgggagcat tttcaccttt cgcaggcgag     1800

acctgggttc tgaagcagat tttgcagatg atgaaaacag cacagcgggg gagagcgaga     1860

gccaccacac atcactgctg gtgccctggc ccctgcgccg gaccagtgcc cagggacagc     1920

ccagtcccgg aacctcggct cctggccacg ccctccatgg caaaaagaac agcactgtgg     1980

actgcaatgg ggtggtctca ttactggggg caggcgaccc agaggccaca tccccaggaa     2040

gccacctcct ccgccctgtg atgctagagc acccgccaga cacgaccacg ccatcggagg     2100

agccaggcgg gccccagatg ctgacctccc aggctccgtg tgtagatggc ttcgaggagc     2160

caggagcacg gcagcgggcc ctcagcgcag tcagcgtcct caccagcgca ctggaagagt     2220

tagaggagtc tcgccacaag tgtccaccat gctggaaccg tctcgcccag cgctacctga     2280

tctgggagtg ctgcccgctg tggatgtcca tcaagcaggg agtgaagttg gtggtcatgg     2340

acccgtttac tgacctcacc atcactatgt gcatcgtact caacacactc ttcatggcgc     2400

tggagcacta caacatgaca agtgaattcg aggagatgct gcaggtcgga aacctggtct     2460

tcacagggat tttcacagca gagatgacct tcaagatcat tgccctcgac ccctactact     2520

acttccaaca gggctggaac atcttcgaca gcatcatcgt catccttagc ctcatggagc     2580

tgggcctgtc ccgcatgagc aacttgtcgg tgctgcgctc cttccgcctg ctgcgggtct     2640

tcaagctggc caaatcatgg cccaccctga acacactcat caagatcatc gggaactcag     2700

tgggggcact ggggaacctg acactggtgc tagccatcat cgtgttcatc tttgctgtgg     2760

tgggcatgca gctctttggc aagaactact cggagctgag ggacagcgac tcaggcctgc     2820

tgcctcgctg gcacatgatg gacttctttc atgccttcct catcatcttc cgcatcctct     2880

gtggagagtg gatcgagacc atgtgggact gcatggaggt gtcggggcag tcattatgcc     2940

tgctggtctt cttgcttgtt atggtcattg gcaaccttgt ggtcctgaat ctcttcctgg     3000

ccttgctgct cagctccttc agtgcagaca acctcacagc ccctgatgag gacagagaga     3060

tgaacaacct ccagctggcc ctggcccgca tccagagggg cctgcgcttt gtcaagcgga     3120

ccacctggga tttctgctgt ggtctcctgc ggcagcggcc tcagaagccc gcagcccttg     3180

ccgcccaggg ccagctgccc agctgcattg ccacccccta ctccccgcca cccccagaga     3240

cggagaaggt gcctcccacc cgcaaggaaa cacggtttga ggaaggcgag caaccaggcc     3300

agggcacccc cggggatcca gagcccgtgt gtgtgcccat cgctgtggcc gagtcagaca     3360

cagatgacca agaagaagat gaggagaaca gcctgggcac ggaggaggag tccagcaagc     3420

agcaggaatc ccagcctgtg tccggtggcc cagaggcccc tccggattcc aggacctgga     3480

gccaggtgtc agcgactgcc tcctctgagg ccgaggccag tgcatctcag gccgactggc     3540

ggcagcagtg gaaagcggaa ccccaggccc cagggtgcgg tgagacccca gaggacagtt     3600

gctccgaggg cagcacagca gacatgacca acaccgctga gctcctggag cagatccctg     3660

acctcggcca ggatgtcaag gacccagagg actgcttcac tgaaggctgt gtccggcgct     3720

gtccctgctg tgcggtggac accacacagg ccccagggaa ggtctggtgg cggttgcgca     3780

agacctgcta ccacatcgtg gagcacagct ggttcgagac attcatcatc ttcatgatcc     3840

tactcagcag tggagcgctg gccttcgagg acatctacct agaggagcgg aagaccatca     3900

aggttctgct tgagtatgcc gacaagatgt tcacatatgt cttcgtgctg gagatgctgc     3960

tcaagtgggt ggcctacggc ttcaagaagt acttcaccaa tgcctggtgc tggctcgact     4020

tcctcatcgt agacgtctct ctggtcagcc tggtggccaa caccctgggc tttgccgaga     4080

tgggccccat caagtcactg cggacgctgc gtgcactccg tcctctgaga gctctgtcac     4140

gatttgaggg catgagggtg gtggtcaatg ccctggtggg cgccatcccg tccatcatga     4200

acgtcctcct cgtctgcctc atcttctggc tcatcttcag catcatgggc gtgaacctct     4260

ttgcggggaa gtttgggagg tgcatcaacc agacagaggg agacttgcct ttgaactaca     4320

ccatcgtgaa caacaagagc cagtgtgagt ccttgaactt gaccggagaa ttgtactgga     4380

ccaaggtgaa agtcaacttt gacaacgtgg gggccgggta cctggccctt ctgcaggtgg     4440

caacatttaa aggctggatg gacattatgt atgcagctgt ggactccagg gggtatgaag     4500

agcagcctca gtgggaatac aacctctaca tgtacatcta ttttgtcatt ttcatcatct     4560

ttgggtcttt cttcaccctg aacctcttta ttggtgtcat cattgacaac ttcaaccaac     4620

agaagaaaaa gttagggggc caggacatct tcatgacaga ggagcagaag aagtactaca     4680

atgccatgaa gaagctgggc tccaagaagc cccagaagcc catcccacgg cccctgaaca     4740

agtaccaggg cttcatattc gacattgtga ccaagcaggc ctttgacgtc accatcatgt     4800

ttctgatctg cttgaatatg gtgaccatga tggtggagac agatgaccaa agtcctgaga     4860

aaatcaacat cttggccaag atcaacctgc tctttgtggc catcttcaca ggcgagtgta     4920

ttgtcaagct ggctgccctg cgccactact acttcaccaa cagctggaat atcttcgact     4980

tcgtggttgt catcctctcc atcgtgggca ctgtgctctc ggacatcatc cagaagtact     5040

tcttctcccc gacgctcttc cgagtcatcc gcctggcccg aataggccgc atcctcagac     5100

tgatccgagg ggccaagggg atccgcacgc tgctctttgc cctcatgatg tccctgcctg     5160

ccctcttcaa catcgggctg ctgctcttcc tcgtcatgtt catctactcc atctttggca     5220

tggccaactt cgcttatgtc aagtgggagg ctggcatcga cgacatgttc aacttccaga     5280

ccttcgccaa cagcatgctg tgcctcttcc agatcaccac gtcggccggc tgggatggcc     5340

tcctcagccc catcctcaac actgggccgc cctactgcga ccccactctg cccaacagca     5400

atggctctcg gggggactgc gggagcccag ccgtgggcat cctcttcttc accacctaca     5460

tcatcatctc cttcctcatc gtggtcaaca tgtacattgc catcatcctg gagaacttca     5520

gcgtggccac ggaggagagc accgagcccc tgagtgagga cgacttcgat atgttctatg     5580

agatctggga gaaatttgac ccagaggcca ctcagtttat tgagtattcg gtcctgtctg     5640

actttgccga tgccctgtct gagccactcc gtatcgccaa gcccaaccag ataagcctca     5700

tcaacatgga cctgcccatg gtgagtgggg accgcatcca ttgcatggac attctctttg     5760

ccttcaccaa aagggtcctg ggggagtctg gggagatgga cgccctgaag atccagatgg     5820

aggagaagtt catggcagcc aacccatcca agatctccta cgagcccatc accaccacac     5880

tccggcgcaa gcacgaagag gtgtcggcca tggttatcca gagagccttc cgcaggcacc     5940

tgctgcaacg ctctttgaag catgcctcct tcctcttccg tcagcaggcg ggcagcggcc     6000

tctccgaaga ggatgcccct gagcgagagg gcctcatcgc ctacgtgatg agtgagaact     6060

tctcccgacc ccttggccca ccctccagct cctccatctc ctccacttcc ttcccaccct     6120

cctatgacag tgtcactaga gccaccagcg ataacctcca ggtgcggggg tctgactaca     6180

gccacagtga agatctcgcc gacttccccc cttctccgga cagggaccgt gagtccatcg     6240

tgtgagcctc ggcctggctg gccaggacac actgaaaagc agcctttttc accatggcaa     6300

acctaaatgc agtcagtcac aaaccagcct ggggccttcc tggctttggg agtaagaaat     6360

gggcctcagc cccgcggatc aaccaggcag agttctgtgg cgccgcgtgg acagccggag     6420

cagttggcct gtgcttggag gcctcagata gacctgtgac ctggtctggt caggcaatgc     6480

cctgcggctc tggaaagcaa cttcatccca gctgctgagg cgaaatataa aactgagact     6540

gtatatgttg tgaatgggct ttcataaatt tattatattt gatatttttt tacttgagca     6600

aagaactaag gatttttcca tggacatggg cagcaattca cgctgtctct tcttaaccct     6660

gaacaagagt gtctatggag cagccggaag tctgttctca aagcagaagt ggaatccagt     6720

gtggctccca caggtcttca ctgcccaggg gtcgaatggg gtccccctcc cacttgacct     6780

gagatgctgg gagggctgaa cccccactca cacaagcaca cacacacagt cctcacacac     6840

ggaggccaga cacaggccgt gggacccagg ctcccagcct aagggagaca ggcctttccc     6900

tgccggcccc ccaaggatgg ggttcttgtc cacggggctc actctggccc cctattgtct     6960

ccaaggtccc attttccccc tgtgttttca cgcaggtcat attgtcagtc ctacaaaaat     7020

aaaaggcttc cagaggagag tggcctgggt cccagggctg gccctaggca ctgatagttg     7080

ccttttcttc ccctcctgta agagtattaa caaaaccaaa ggacacaagg gtgcaagccc     7140

cattcacggc ctggcatgca gcttgtcctt gctcctggaa cctggcaggc cctgcccagc     7200

cagccatcgg aagagagggc tgagccatgg gggtttgggg ctaagaagtt caccagccct     7260

gagccatggc ggcccctcag cctgcctgaa gagaggaaac tggcgatctc ccagggctct     7320

ctggaccata cgcggaggag ttttctgtgt ggtctccagc tcctctccag acacagagac     7380

atgggagtgg ggagcggagc ttggccctgc gccctgtgca gggaaaggga tggtcaggcc     7440

cagttctcgt gcccttagag gggaatgaac catggcacct ttgagagagg gggcactgtg     7500

gtcaggccca gcctctctgg ctcagcccgg gatcctgatg gcacccacac agaggacctc     7560

tttggggcaa gatccaggtg gtcccatagg tcttgtgaaa aggctttttc agggaaaaat     7620

attttactag tccaatcacc cccaggacct cttcagctgc tgacaatcct atttagcata     7680

tgcaaatctt ttaacataga gaactgtcac cctgaggtaa cagggtcaac tggcgaagcc     7740

tgagcaggca ggggcttggc tgccccattc cagctctccc atggagcccc tccaccgggc     7800

gcatgcctcc caggccacct cagtctcacc tgccggctct gggctggctg ctcctaacct     7860

acctcgccga gctgtcggag ggctggacat ttgtggcagt gctgaagggg gcattgccgg     7920

cgagtaaagt attatgtttc ttcttgtcac cccagttccc ttggtggcaa ccccagaccc     7980

aacccatgcc cctgacagat ctagttctct tctcctgtgt tccctttgag tccagtgtgg     8040

gacacggttt aactgtccca gcgacatttc tccaagtgga aatcctattt ttgtagatct     8100

ccatgctttg ctctcaaggc ttggagaggt atgtgcccct cctgggtgct caccgcctgc     8160

tacacaggca ggaatgcggt tgggaggcag gtcgggctgc cagcccagct ggccggaagg     8220

agactgtggt ttttgtgtgt gtggacagcc cgggagcttt gagacaggtg cctggggctg     8280

gctgcagacg gtgtggttgg gggtgggagg tgagctagac ccaaccctta gcttttagcc     8340

tggctgtcac ctttttaatt tccagaactg cacaatgacc agcaggaggg aaggacagac     8400

atcaagtgcc agatgttgtc tgaactaatc gagcacttct caccaaactt catgtataaa     8460

taaaatacat atttttaaaa caaaccaata aatggcttac atga                      8504


<210>  14
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ser Asn Gly Tyr Glu Asp His Met Ala Glu Asp Cys Arg Gly Asp 
1               5                   10                  15      


Ile Gly Arg Thr Asn Leu Ile Val Asn Tyr Leu Pro Gln Asn Met Thr 
            20                  25                  30          


Gln Asp Glu Leu Arg Ser Leu Phe Ser Ser Ile Gly Glu Val Glu Ser 
        35                  40                  45              


Ala Lys Leu Ile Arg Asp Lys Val Ala Gly His Ser Leu Gly Tyr Gly 
    50                  55                  60                  


Phe Val Asn Tyr Val Thr Ala Lys Asp Ala Glu Arg Ala Ile Asn Thr 
65                  70                  75                  80  


Leu Asn Gly Leu Arg Leu Gln Ser Lys Thr Ile Lys Val Ser Tyr Ala 
                85                  90                  95      


Arg Pro Ser Ser Glu Val Ile Lys Asp Ala Asn Leu Tyr Ile Ser Gly 
            100                 105                 110         


Leu Pro Arg Thr Met Thr Gln Lys Asp Val Glu Asp Met Phe Ser Arg 
        115                 120                 125             


Phe Gly Arg Ile Ile Asn Ser Arg Val Leu Val Asp Gln Thr Thr Gly 
    130                 135                 140                 


Leu Ser Arg Gly Val Ala Phe Ile Arg Phe Asp Lys Arg Ser Glu Ala 
145                 150                 155                 160 


Glu Glu Ala Ile Thr Ser Phe Asn Gly His Lys Pro Pro Gly Ser Ser 
                165                 170                 175     


Glu Pro Ile Thr Val Lys Phe Ala Ala Asn Pro Asn Gln Asn Lys Asn 
            180                 185                 190         


Val Ala Leu Leu Ser Gln Leu Tyr His Ser Pro Ala Arg Arg Phe Gly 
        195                 200                 205             


Gly Pro Val His His Gln Ala Gln Arg Phe Arg Phe Ser Pro Met Gly 
    210                 215                 220                 


Val Asp His Met Ser Gly Leu Ser Gly Val Asn Val Pro Gly Asn Ala 
225                 230                 235                 240 


Ser Ser Gly Trp Cys Ile Phe Ile Tyr Asn Leu Gly Gln Asp Ala Asp 
                245                 250                 255     


Glu Gly Ile Leu Trp Gln Met Phe Gly Pro Phe Gly Ala Val Thr Asn 
            260                 265                 270         


Val Lys Val Ile Arg Asp Phe Asn Thr Asn Lys Cys Lys Gly Phe Gly 
        275                 280                 285             


Phe Val Thr Met Thr Asn Tyr Glu Glu Ala Ala Met Ala Ile Ala Ser 
    290                 295                 300                 


Leu Asn Gly Tyr Arg Leu Gly Asp Lys Ile Leu Gln Val Ser Phe Lys 
305                 310                 315                 320 


Thr Asn Lys Ser His Lys 
                325     


<210>  15
<211>  6075
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HuR cDNA sequence

<400>  15
ggtcgtgcgc gctgaggagg agccgctgcc gccgtcgccg tcgccgccac cgccgccacc       60

gctaccgagg ccgagcggag ccgttagcgc cgcgccgccg ccgcctcccg cccgccccgg      120

agcagccccg ggcccgcccg cccgcatcca gatttttgaa aaatacaatg tctaatggtt      180

atgaagacca catggccgaa gactgcaggg gtgacatcgg gagaacgaat ttgatcgtca      240

actacctccc tcagaacatg acccaggatg agttacgaag cctgttcagc agcattggtg      300

aagttgaatc tgcaaaactt attcgggata aagtagcagg acacagcttg ggctatggct      360

ttgtgaacta cgtgaccgcg aaggatgcag agagagcgat caacacgctg aacggcttga      420

ggctccagtc aaaaaccatt aaggtgtcgt atgctcgccc gagctcagag gtgatcaaag      480

acgccaactt gtacatcagc gggctcccgc ggaccatgac ccagaaggac gtagaagaca      540

tgttctctcg gtttgggcgg atcatcaact cgcgggtcct cgtggatcag actacaggtt      600

tgtccagagg ggttgcgttt atccggtttg acaaacggtc ggaggcagaa gaggcaatta      660

ccagtttcaa tggtcataaa cccccaggtt cctctgagcc catcacagtg aagtttgcag      720

ccaaccccaa ccagaacaaa aacgtggcac tcctctcgca gctgtaccac tcgccagcgc      780

gacggttcgg aggccccgtt caccaccagg cgcagagatt caggttctcc cccatgggcg      840

tcgatcacat gagcgggctc tctggcgtca acgtgccagg aaacgcctcc tccggctggt      900

gcattttcat ctacaacctg gggcaggatg ccgacgaggg gatcctctgg cagatgtttg      960

ggccgtttgg tgccgtcacc aatgtgaaag tgatccgcga cttcaacacc aacaagtgca     1020

aagggtttgg ctttgtgacc atgacaaact atgaagaagc cgcgatggcc atagccagcc     1080

tgaacggcta ccgcctgggg gacaaaatct tacaggtttc cttcaaaacc aacaagtccc     1140

acaaataact cgctcatgct tttttttgta cggaatagat aattaagagt gaaggagttg     1200

aaacttttct tgttagtgta caactcattt tgcgccaatt ttcacaagtg tttgtctttg     1260

tctgaatgag aagtgagaag gtttttatac tctgggatgc aaccgacatg ttcaaatgtt     1320

tgaaatccca caatgttaga ccaatcttaa gtttcgtaag ttatttcctt taagatatat     1380

attaaacaga aatctaagta gaactgcatt gactaaccag tccctctgga tggtggtgaa     1440

cctgaagcat gctttaacct ctaagactgt ctaacacgcg tttcattcaa tgtctccaca     1500

gactgggtag caaaaaaatc accttttagt tttagttttt aatctaaaga tgttagacag     1560

atgctgagtg tgcgttttct caaccgcttc aacattgtaa gcgatgtatg ctttggttga     1620

caggaagttc cttttccagg caggtcccgt tgccacctcc tgctcactca gtcccgggct     1680

ctgccgagtg gtcctgggaa tggcggcggg cccgtccagc gtgggccacc actggggccg     1740

ggggccacgg gctgcatgct gggcgggccc tccagagaag gacacaaacg tgtttcgtaa     1800

gcccaggcac caatgggaat ggaccaaaga gtttcaggga aactccagta tattccagag     1860

tcagatctaa gctccaggca cgcctgaaga tgtgttgcta ctctgacatc ccgagtttct     1920

gtccacacat tgcatgcaca gcgccccaca cattggatac tgttgttcac gataatttct     1980

cccgttttcc agagcattta acatagcttg gaggcgtaaa atggctctgt attttaataa     2040

cacagaaaca tttgagcatt gtatttctcg catcccttct cgtgagcgct tagacctttt     2100

tctattttag tcggattttg ttttggaatt ttgcttttgt atgaacactc agcagaaaag     2160

tacttacttc ttgccagtta tctattaacc aaaacctttg atttgtagtt ttaaagatta     2220

accctcaaag ttctcttcat aactgccttg acattttggg ttgttctgtt ctgttaattt     2280

tcttttgctt ttttgtgttt tttgtttgtt tttacttttg catttaagac cattaaattt     2340

gattttgttt tgctcgaatt ttgttttgtt ttttatttta ccttttcttt ctttttggct     2400

agggaaggtg caggtggccc agcattcagg gaggagtcgt aagatcttaa gaaaccaatc     2460

cttgcctcaa gcaaaagcat ttctgaatct gtgacgcaag aatgtgcagt tacaggctgg     2520

tggcttttaa accaggagcc cggaggaagg gtgaaagaga aagcctgtga aataggcagg     2580

gccagatcac ccaaaactcc tcaggactgg gatctggcgt ttataaataa ctagtttaca     2640

gagagaatca caaacaggat aacttagtac cagcagtttt taaccttgac gtgagactaa     2700

aacgtgaccg taggctgttt tttagttatt gctctcatga gatgatggct gtatttatct     2760

gtttatttat acctatttat gtatttattt attgaagtgt gaaattgagc aataggcagg     2820

caccaccgtc cccagagcag gtcagcgtct cgagaggccc ctggacaatt gaggatgccc     2880

atcccctccc ctttccctga tcttttactg aggggctgtg tgcgcgatcc ttgcaaattg     2940

atgatgttgc catccgtacc caggctgtgt ctcataaaag tcggcctggt gccagagagg     3000

acctcctttc tcccacagaa tcccagatcc tcaggaaaag ccaaaaccga ggcccattgc     3060

ccggattcga cacaaaagag ggtccctgct ctgttgcccg agagcagtct gcatcctggg     3120

accagaatgc tttcctggaa aaagaagcct ttcaggtttc cctgggccag catcttctga     3180

tggaaggtgg gagccaacac ccttctgatg gaaggtggga gccaacaccc ttctgatgga     3240

aggtgggagc caacaccctt ctgatggaag gtgggagcca acacccttct gatggaaggt     3300

gggagccaac acccttctga tggaaggcgg gattcccgct tctgaaactc cccctggagt     3360

ctcactccca cacatgccca tagctagcat tcaacagaga actctgtctt aagcttcaac     3420

tgtgaaaatg atgacgggct tgtagcacct cagcttcttt cctcgccccc ttttatctga     3480

atcctatcaa ttattctgat gctgggacag gtgagaagaa actgtgaagt atatgagcct     3540

ttgaaagttc cctgaagttt ctcagttcag gaacattctc attgtatgtg gtctccgctg     3600

tttgaacagc cttctagcta aaaaattcca aagcctttat ttgggagtct tagcttgcaa     3660

gcttgtggaa ggatttagct taacaactgt cactcctgaa aagcaatctc tgttccatca     3720

aggttctagt tgctggccct gtgtcctcaa agttcattac atcttatcaa ggcctgtttg     3780

caaaggggag atcccttttc ttaaaaaagg ctcaacccaa aagaaaccat ttcttaaaaa     3840

attttacata gatcagttgt atttctattt agcaaaaatg agtgctctgc ttttatttgg     3900

gaatttcgat gaaaaagcgt tcagagtaga taatgttcat ttatcaaaaa tctggtttgg     3960

gaaataccaa agaggctttg attgaattcc cttttgaccc gtgtgtaact tcctctggta     4020

gttagacccc aggcagctcc gaatttgtga acctgcttcc tgatgaattc tcccttgttc     4080

ccccttggct ctgccattat ttcgttttca gtgtaatttg ccaagccgca gttttctgtg     4140

ctggctgtgc ctctagtcgc agctctgtga ctgattccct cccgggtgct gagtcccctc     4200

cccggccacc atcctgcgtg aatatcctga aattcatggg cttcctcggg ggcccgcccg     4260

caggtggtgc tgggtgggtt ccgccacctt ctcctggaag gtgagccttt tcctggccaa     4320

gggcagctgc cttaacctct gagagtctgc gcttggcctt agtcctggag acccagcctc     4380

cagggactga accgtgctgc tgttgggagc caagaccggc cctttggagc cggcagccca     4440

ggggtccctg ctggatcaga gaaatagaag cacccgaaga cggttagtgg caattccttg     4500

acccggtttg cttccaaatg aaggccattt gtccaccagg cattgaaaag acatgactta     4560

cccagtccgg catcggactt gaaaaatcga aattgacatc actcagctgt tacatttcac     4620

atccgattca gccccctttt atttccatgt gcttttcgca gccttcctgt gttggatgaa     4680

agagaataag aattcagctg acaggaggcc tctatcctgt ccctccaccc caccctccac     4740

ctcaatcccc tcccatcttc cccagaccta cctcacctac taggacctga ggcagctcct     4800

tagcagagac ccctggggtt tagctgactc tgggggtcag gggttcctgt ccccaaactt     4860

cgcaagacag ccctgaagtc acaagtgctt tcttttaagt ggcattggca attggcgtgt     4920

aatgatggca gtagaatctg aatctcggat cccaggcagg gttcacattt ccaaaccttt     4980

ttgatttccc ctgacctcta atggctggat cctatttttc tacaaccttt cagtgacatc     5040

gttcaggttt ctttcttggc catttaaaaa aacaaatttt ttttttctca cttgtaagtc     5100

accgccagta cctaagttag gctaacggag actttgacag gactggattt ttcttccacc     5160

agaagagaag ccttttccgt tggtttgggg ccacctcttt gaccatgacc atgtgatgtt     5220

ccgtttacag tgacttgctt tgggggaggg gaggctctct taaccgattc ccatgttgta     5280

cagtagatgg ttagaccttt tgtatattag tgtgttttaa gttattgatt tgttttatat     5340

aaaataattt atttttcagg tgccattttt cattttaact ttgtttttac atgggtttgt     5400

tttcaataaa gtctgacact ggtgtccaaa agtcaacaat aaaatgaatc ccattgtgtt     5460

cttttgaaga tgcctatgta acttttaagc tttttaaatt attttcagaa aaaaaaaaag     5520

aaaagccctt atcagttttc catcagccca ttgccttttt attttttttt tttaatcctt     5580

gtgaataaat gttctttagt gttttaggag gaaaaagcaa acctagattt tgataaccca     5640

gaagacttca gattaataaa gaagctttga aagaagacca tttttcaaaa ttttagtgaa     5700

gtgtgaatat tttttgtcaa tggctttctc aaagagaatg aaacttttgc accattttca     5760

gagtttttat agagatgcca aattgatata tttacatgta atggaaacat gaaaaagttt     5820

tattaaacaa ttgttcatag ctgtgtagac attttaattc agtttccaaa gctctcaaaa     5880

aatcgtattt ttgaagtacg gagtgatgcg gtttggggcg tggcttacag ttccaacgac     5940

tcaattgtcc cgatactcag ttctttctac aggtatcagg ttcgtgttaa acgctgtatg     6000

ttaactatga ctggaattct gtgatatttt ggtaataaat gaagtgggat cattgcgaaa     6060

aaaaaaaaaa aaaaa                                                      6075


<210>  16
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Glu Thr Gln Leu Ser Asn Gly Pro Thr Cys Asn Asn Thr Ala Asn 
1               5                   10                  15      


Gly Pro Thr Thr Ile Asn Asn Asn Cys Ser Ser Pro Val Asp Ser Gly 
            20                  25                  30          


Asn Thr Glu Asp Ser Lys Thr Asn Leu Ile Val Asn Tyr Leu Pro Gln 
        35                  40                  45              


Asn Met Thr Gln Glu Glu Leu Lys Ser Leu Phe Gly Ser Ile Gly Glu 
    50                  55                  60                  


Ile Glu Ser Cys Lys Leu Val Arg Asp Lys Ile Thr Gly Gln Ser Leu 
65                  70                  75                  80  


Gly Tyr Gly Phe Val Asn Tyr Ile Asp Pro Lys Asp Ala Glu Lys Ala 
                85                  90                  95      


Ile Asn Thr Leu Asn Gly Leu Arg Leu Gln Thr Lys Thr Ile Lys Val 
            100                 105                 110         


Ser Tyr Ala Arg Pro Ser Ser Ala Ser Ile Arg Asp Ala Asn Leu Tyr 
        115                 120                 125             


Val Ser Gly Leu Pro Lys Thr Met Thr Gln Lys Glu Leu Glu Gln Leu 
    130                 135                 140                 


Phe Ser Gln Tyr Gly Arg Ile Ile Thr Ser Arg Ile Leu Val Asp Gln 
145                 150                 155                 160 


Val Thr Gly Ile Ser Arg Gly Val Gly Phe Ile Arg Phe Asp Lys Arg 
                165                 170                 175     


Ile Glu Ala Glu Glu Ala Ile Lys Gly Leu Asn Gly Gln Lys Pro Pro 
            180                 185                 190         


Gly Ala Thr Glu Pro Ile Thr Val Lys Phe Ala Asn Asn Pro Ser Gln 
        195                 200                 205             


Lys Thr Asn Gln Ala Ile Leu Ser Gln Leu Tyr Gln Ser Pro Asn Arg 
    210                 215                 220                 


Arg Tyr Pro Gly Pro Leu Ala Gln Gln Ala Gln Arg Phe Arg Leu Asp 
225                 230                 235                 240 


Asn Leu Leu Asn Met Ala Tyr Gly Val Lys Arg Phe Ser Pro Met Thr 
                245                 250                 255     


Ile Asp Gly Met Thr Ser Leu Ala Gly Ile Asn Ile Pro Gly His Pro 
            260                 265                 270         


Gly Thr Gly Trp Cys Ile Phe Val Tyr Asn Leu Ala Pro Asp Ala Asp 
        275                 280                 285             


Glu Ser Ile Leu Trp Gln Met Phe Gly Pro Phe Gly Ala Val Thr Asn 
    290                 295                 300                 


Val Lys Val Ile Arg Asp Phe Asn Thr Asn Lys Cys Lys Gly Phe Gly 
305                 310                 315                 320 


Phe Val Thr Met Thr Asn Tyr Asp Glu Ala Ala Met Ala Ile Ala Ser 
                325                 330                 335     


Leu Asn Gly Tyr Arg Leu Gly Asp Arg Val Leu Gln Val Ser Phe Lys 
            340                 345                 350         


Thr Asn Lys Thr His Lys Ala 
        355                 


<210>  17
<211>  3814
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HuB cDNA sequence

<400>  17
caataggagg gtagtctctc cgtcttttta aactcttttt taagtttccc ctcccctttc       60

atattttttt tcgccatttc ttttagcatt ggactttggg gtcgaaagcg tttcttttta      120

tttgcttctt ttaagccgag cacagtttag gtttcgtgct gtcttaagag aactatccag      180

cagcttcttg ctcatcctta ttgggagaac tgcaccgtta ctttaaaaac acacatacac      240

aaaaacctta agggagaaag caggtaattg ctgccatgga aacacaactg tctaatgggc      300

caacttgcaa taacacagcc aatggtccaa ccaccataaa caacaactgt tcgtcaccag      360

ttgactctgg gaacacagaa gacagcaaga ccaacttaat agtcaactac cttcctcaga      420

acatgacaca ggaggaacta aagagtctct ttgggagcat tggtgaaata gagtcctgta      480

agcttgtaag agacaaaata acagggcaga gcttgggata tggctttgtg aactacattg      540

accccaagga tgcagagaaa gctatcaaca ccctgaatgg attgagactt caaaccaaaa      600

caataaaagt ttcctatgct cgcccaagtt cagcttctat cagagatgca aatttatatg      660

tcagcggact tccaaaaaca atgacccaga aggagttgga acagcttttt tcacaatatg      720

gacgcattat tacttctcgt attcttgtcg accaggtcac tggcatatca aggggtgtag      780

ggtttattcg atttgacaag cgaattgagg cagaagaagc tatcaaaggc ctaaatggcc      840

agaaacctcc cggtgccacg gagccaatca ctgtaaagtt tgctaataac ccaagccaaa      900

aaaccaatca ggccatcctt tcccagctgt accagtctcc aaacagaagg tatccaggac      960

cgctagctca gcaggcacag cgttttaggt tggacaatct gctcaatatg gcttatggag     1020

taaagaggtt ttctccaatg accattgacg gaatgaccag tttggctgga attaatatcc     1080

ctgggcaccc tggaacaggg tggtgtatat ttgtgtacaa cctggctcct gacgcagatg     1140

agagtatcct gtggcaaatg tttgggcctt ttggagctgt caccaatgtg aaggtcatcc     1200

gtgactttaa caccaataaa tgcaaaggtt ttggatttgt gactatgaca aactatgatg     1260

aggctgccat ggcgatagct agcctcaatg gataccgtct gggagacaga gtactgcagg     1320

tctcctttaa gacaaacaaa acgcacaaag cctaatgagc tcttgtcctc agtccattta     1380

tatatgaaaa ctatacaaca aaggcaagtt aagagaaact ttatacatta gtaaatgtct     1440

ttgtaagtca gtgttgagat ggggataaaa tgactactta gcatcctaag aaatatgtga     1500

gattttttat tgctagtatt tgaattaaaa cttcttaaat atcttttatg tttgaatatg     1560

gacaagaggt acagggtttt tacctgtcac attgcattct attgccttct ttgaagaagg     1620

tggacctttt aaagtgtttc agctaaggga agacatttct tttcttttta cataactgcc     1680

ttgaacctgt gagtaaatat tgaggctttg tgttgtaatt cttcagttgg ttgtgtcttt     1740

tttttccccc ctttttttcc tttttctgat tagctttgtg tttggtttac atttaaagca     1800

ttgctgttat gtctgtttaa gaaaagtatt ttgaagttta catttttatt tatgaagttt     1860

aaaacagtat ttattttgta attatgattt gggttgggga agggggggct acattataaa     1920

cgcttattgt aagaatactg gagaactttt cgtaaagcag taccttgcca aagagataag     1980

agcctctttg atgtgggttt aaaaaaagca tctattttta taaaaaagaa aatttggaga     2040

aactttttac tggtcctgga acaaatattt tgacttgaat actttgagaa atctcttcat     2100

atgacaccta gtgagctttt aaaatttacc aggaaatttg cagcggttgg aaaatttaga     2160

aagatttatg gtgtagaaaa tacttttgag atctttgtat gaaaggagta gaatcaatgg     2220

ggggaaacac tgctggtttc atttttgtaa tcaccagtgg agcgtctgat catcctggtt     2280

attatgtgat aggtggctca cattgatttg tgattttgaa acaaataaaa aaaatttaca     2340

aaagaatata taagagcagg caagaaattt aaattaccga gagatggggg aaaaaatctg     2400

ttcttcctaa agaaatccct tcagatagag ctcatggtgt ttagtgatgt acttgcagta     2460

ttgtttgaag aattgttttg tcttaaggaa aaaagacgtt gcacatgatt tgtactgcag     2520

caaatcagca aaagtgatct gagttggata tatttgaagg tattttgaaa gttacgttca     2580

aggctaacac ctgagctttg tgtaatgtaa ataagacctt gtgtttatga acctttcagc     2640

taatttaatt ttttttccct tacatgccaa gtgatgttca ggttttgaat gtttttgtat     2700

cagttttttc ctttgtaaat ggcattaaca ttgttacttg aggtcttgct taatcacttt     2760

tgttgtcctg aggacttgaa tttacagtgc atcagatttg ttgcaaattt tgtctgtaga     2820

tagtctagct tcagctgttt atggtgatgc tacattttcg tttataaata tgtttgtggt     2880

ataaaaaaat gagtataacc ataggttttg aacaaatttc cttacatttt tcatacaaaa     2940

atcataaata tctgtatgct attgaaattt aactttgtat gatgcttaaa aaccactatt     3000

tggggaaata ataaaataag tctttaccat gtatgaaaga aattttaaaa aatacaaaat     3060

attttctgat tagcatctag cttataataa attttcaaaa aagctgaagg caaaaatgcc     3120

ttcatcagga tgcactgaga actatatagt tacgtcctgc tttttgtata aactgagatg     3180

ctcacatgct tccccttaga acaggcaatg tgctatgcat aacatagttg tacattatct     3240

ttgcggttgc tttgagtttt attttttatt atttaaaatt gtagttataa aatttttcag     3300

tatagtacag tacatatact gtgaggcgcg tgctaaagtg aataagcgag ttttcatgct     3360

gacccactca atgctattca gaaatcaatt ggcttagcac tttctcatat ccttaggtgc     3420

atttagattg ccagagttaa ccttctgcgt ttaaaaaaag aaaaacacta aaaaataaaa     3480

tacatgtata tacttaaaaa aaaataataa ggtttccctc aagggaaaac agcagctaca     3540

tgcttctttc ctatactact gtagcaaacc aaggcattga tgagagggca tgcaaattgt     3600

gcttcacttt acagtgtttt atcagagcac ttaataaaat gtaaggctgg tatttatttg     3660

aagttgtaca gtatgactta attcacatct gttggaatag aaaatatatt ctgttgagta     3720

tttaagaggc tgtacatgtt ttcttttgtg tttggattct ttgtactttt tcatgttcag     3780

tacatcaata aacaaagttg aagggaaaaa aaaa                                 3814


<210>  18
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gly Arg Lys Lys Ile Gln Ile Thr Arg Ile Met Asp Glu Arg Asn 
1               5                   10                  15      


Arg Gln Val Thr Phe Thr Lys Arg Lys Phe Gly Leu Met Lys Lys Ala 
            20                  25                  30          


Tyr Glu Leu Ser Val Leu Cys Asp Cys Glu Ile Ala Leu Ile Ile Phe 
        35                  40                  45              


Asn Ser Thr Asn Lys Leu Phe Gln Tyr Ala Ser Thr Asp Met Asp Lys 
    50                  55                  60                  


Val Leu Leu Lys Tyr Thr Glu Tyr Asn Glu Pro His Glu Ser Arg Thr 
65                  70                  75                  80  


Asn Ser Asp Ile Val Glu Thr Leu Arg Lys Lys Gly Leu Asn Gly Cys 
                85                  90                  95      


Asp Ser Pro Asp Pro Asp Ala Asp Asp Ser Val Gly His Ser Pro Glu 
            100                 105                 110         


Ser Glu Asp Lys Tyr Arg Lys Ile Asn Glu Asp Ile Asp Leu Met Ile 
        115                 120                 125             


Ser Arg Gln Arg Leu Cys Ala Val Pro Pro Pro Asn Phe Glu Met Pro 
    130                 135                 140                 


Val Ser Ile Pro Val Ser Ser His Asn Ser Leu Val Tyr Ser Asn Pro 
145                 150                 155                 160 


Val Ser Ser Leu Gly Asn Pro Asn Leu Leu Pro Leu Ala His Pro Ser 
                165                 170                 175     


Leu Gln Arg Asn Ser Met Ser Pro Gly Val Thr His Arg Pro Pro Ser 
            180                 185                 190         


Ala Gly Asn Thr Gly Gly Leu Met Gly Gly Asp Leu Thr Ser Gly Ala 
        195                 200                 205             


Gly Thr Ser Ala Gly Asn Gly Tyr Gly Asn Pro Arg Asn Ser Pro Gly 
    210                 215                 220                 


Leu Leu Val Ser Pro Gly Asn Leu Asn Lys Asn Met Gln Ala Lys Ser 
225                 230                 235                 240 


Pro Pro Pro Met Asn Leu Gly Met Asn Asn Arg Lys Pro Asp Leu Arg 
                245                 250                 255     


Val Leu Ile Pro Pro Gly Ser Lys Asn Thr Met Pro Ser Val Ser Glu 
            260                 265                 270         


Asp Val Asp Leu Leu Leu Asn Gln Arg Ile Asn Asn Ser Gln Ser Ala 
        275                 280                 285             


Gln Ser Leu Ala Thr Pro Val Val Ser Val Ala Thr Pro Thr Leu Pro 
    290                 295                 300                 


Gly Gln Gly Met Gly Gly Tyr Pro Ser Ala Ile Ser Thr Thr Tyr Gly 
305                 310                 315                 320 


Thr Glu Tyr Ser Leu Ser Ser Ala Asp Leu Ser Ser Leu Ser Gly Phe 
                325                 330                 335     


Asn Thr Ala Ser Ala Leu His Leu Gly Ser Val Thr Gly Trp Gln Gln 
            340                 345                 350         


Gln His Leu His Asn Met Pro Pro Ser Ala Leu Ser Gln Leu Gly Ala 
        355                 360                 365             


Cys Thr Ser Thr His Leu Ser Gln Ser Ser Asn Leu Ser Leu Pro Ser 
    370                 375                 380                 


Thr Gln Ser Leu Asn Ile Lys Ser Glu Pro Val Ser Pro Pro Arg Asp 
385                 390                 395                 400 


Arg Thr Thr Thr Pro Ser Arg Tyr Pro Gln His Thr Arg His Glu Ala 
                405                 410                 415     


Gly Arg Ser Pro Val Asp Ser Leu Ser Ser Cys Ser Ser Ser Tyr Asp 
            420                 425                 430         


Gly Ser Asp Arg Glu Asp His Arg Asn Glu Phe His Ser Pro Ile Gly 
        435                 440                 445             


Leu Thr Arg Pro Ser Pro Asp Glu Arg Glu Ser Pro Ser Val Lys Arg 
    450                 455                 460                 


Met Arg Leu Ser Glu Gly Trp Ala Thr 
465                 470             


<210>  19
<211>  6194
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MEF2C cDNA sequence

<400>  19
aagggggcaa agcctcggtc ttcatagaaa aggagaggag gcaaacgcag cccaaactgg       60

ggggtttctc ttcaaagcca gctggtctgg ctttattctg caggaatttt tttacctgtc      120

agggtttgga caacaaagcc ctcagcaggt gctgacgggt acaacttcct ggagaagcag      180

aaaggcactg gtgccaaaga agagttgcaa actgtgaagt aacttctatg aagagatgaa      240

gtaaagaacg gaaggcaaat gattgtggca gtaaagaagt gtatgtgcag gaacgaatgc      300

aggaatttgg gaactgagct gtgcaagtgc tgaagaagga gatttgtttg gaggaaacag      360

gaaagagaaa gaaaaggaag gaaaaaatac ataatttcag ggacgagaga gagaagaaaa      420

acggggacta tggggagaaa aaagattcag attacgagga ttatggatga acgtaacaga      480

caggtgacat ttacaaagag gaaatttggg ttgatgaaga aggcttatga gctgagcgtg      540

ctgtgtgact gtgagattgc gctgatcatc ttcaacagca ccaacaagct gttccagtat      600

gccagcaccg acatggacaa agtgcttctc aagtacacgg agtacaacga gccgcatgag      660

agccggacaa actcagacat cgtggaggca ttgaacaaga aagaaaacaa aggctgtgaa      720

agccccgatc ccgactcctc ttatgcactc accccacgca ctgaagaaaa atacaaaaaa      780

attaatgaag aatttgataa tatgatcaag agtcataaaa ttcctgctgt tccacctccc      840

aacttcgaga tgccagtctc catcccagtg tccagccaca acagtttggt gtacagcaac      900

cctgtcagct cactgggaaa ccccaaccta ttgccactgg ctcacccttc tctgcagagg      960

aatagtatgt ctcctggtgt aacacatcga cctccaagtg caggtaacac aggtggtctg     1020

atgggtggag acctcacgtc tggtgcaggc accagtgcag ggaacgggta tggcaatccc     1080

cgaaactcac caggtctgct ggtctcacct ggtaacttga acaagaatat gcaagcaaaa     1140

tctcctcccc caatgaattt aggaatgaat aaccgtaaac cagatctccg agttcttatt     1200

ccaccaggca gcaagaatac gatgccatca gtgaatcaaa ggataaataa ctcccagtcg     1260

gctcagtcat tggctacccc agtggtttcc gtagcaactc ctactttacc aggacaagga     1320

atgggaggat atccatcagc catttcaaca acatatggta ccgagtactc tctgagtagt     1380

gcagacctgt catctctgtc tgggtttaac accgccagcg ctcttcacct tggttcagta     1440

actggctggc aacagcaaca cctacataac atgccaccat ctgccctcag tcagttggga     1500

gcttgcacta gcactcattt atctcagagt tcaaatctct ccctgccttc tactcaaagc     1560

ctcaacatca agtcagaacc tgtttctcct cctagagacc gtaccaccac cccttcgaga     1620

tacccacaac acacgcgcca cgaggcgggg agatctcctg ttgacagctt gagcagctgt     1680

agcagttcgt acgacgggag cgaccgagag gatcaccgga acgaattcca ctcccccatt     1740

ggactcacca gaccttcgcc ggacgaaagg gaaagtccct cagtcaagcg catgcgactt     1800

tctgaaggat gggcaacatg atcagattat tacttactag tttttttttt tttcttgcag     1860

tgtgtgtgtg tgctatacct taatggggaa ggggggtcga tatgcattat atgtgccgtg     1920

tgtggaaaaa aaaaaagtca ggtactctgt tttgtaaaag tacttttaaa ttgcctcagt     1980

gatacagtat aaagataaac agaaatgctg agataagctt agcacttgag ttgtacaaca     2040

gaacacttgt acaaaataga ttttaaggct aacttctttt cactgttgtg ctcctttgca     2100

aaatgtatgt tacaatagat agtgtcatgt tgcaggttca acgttattta catgtaaata     2160

gacaaaagga aacatttgcc aaaagcggca gatctttact gaaagagaga gcagctgtta     2220

tgcaacatat agaaaaatgt atagatgctt ggacagaccc ggtaatgggt ggccattggt     2280

aaatgttagg aacacaccag gtcacctgac atcccaagaa tgctcacaaa cctgcaggca     2340

tatcattggc gtatggcact cattaaaaag gatcagagac cattaaaaga ggaccatacc     2400

tattaaaaaa aaatgtggag ttggagggct aacatattta attaaataaa taaataaatc     2460

tgggtctgca tctcttatta aataaaaata taaaaatatg tacattacat tttgcttatt     2520

ttcatataaa aggtaagaca gagtttgcaa agcatttgtg gctttttgta gtttacttaa     2580

gccaaaatgt gtttttttcc ccttgatagc ttcgctaata ttttaaacag tcctgtaaaa     2640

aaccaaaaag gactttttgt atagaaagca ctaccctaag ccatgaagaa ctccatgctt     2700

tgctaaccaa gataactgtt ttctctttgt agaagttttg tttttgaaat gtgtatttct     2760

aattatataa aatattaaga atcttttaaa aaaatctgtg aaattaacat gcttgtgtat     2820

agctttctaa tatatataat attatggtaa tagcagaagt tttgttatct taatagcggg     2880

aggggggtat atttgtgcag ttgcacattt gagtaactat tttctttctg ttttctttta     2940

ctctgcttac attttataag tttaaggtca gctgtcaaaa ggataacctg tggggttaga     3000

acatatcaca ttgcaacacc ctaaattgtt tttaatacat tagcaatcta ttgggtcaac     3060

tgacatccat tgtatatact agtttctttc atgctatttt tattttgttt tttgcatttt     3120

tatcaaatgc agggcccctt tctgatctca ccatttcacc atgcatcttg gaattcagta     3180

agtgcatatc ctaacttgcc catattctaa atcatctggt tggttttcag cctagaattt     3240

gatacgcttt ttagaaatat gcccagaata gaaaagctat gttggggcac atgtcctgca     3300

aatatggccc tagaaacaag tgatatggaa tttacttggt gaataagtta taaattccca     3360

cagaagaaaa atgtgaaaga ctgggtgcta gacaagaagg aagcaggtaa agggatagtt     3420

gctttgtcat ccgtttttaa ttattttaac tgacccttga caatcttgtc agcaatatag     3480

gactgttgaa caatcccggt gtgtcaggac ccccaaatgt cacttctgca taaagcatgt     3540

atgtcatcta ttttttcttc aataaagaga tttaatagcc atttcaagaa atcccataaa     3600

gaacctctct atgtcccttt ttttaattta aaaaaaatga ctcttgtcta atattcgtct     3660

ataagggatt aattttcaga ccctttaata agtgagtgcc ataagaaagt caatatatat     3720

tgtttaaaag atatttcagt ctaggaaaga ttttccttct cttggaatgt gaagatctgt     3780

cgattcatct ccaatcatat gcattgacat acacagcaaa gaagatatag gcagtaatat     3840

caacactgct atatcatgtg taggacattt cttatccatt ttttctcttt tacttgcata     3900

gttgctatgt gtttctcatt gtaaaaggct gccgctgggt ggcagaagcc aagagacctt     3960

attaactagg ctatattttt cttaacttga tctgaaatcc acaattagac cacaatgcac     4020

ctttggttgt atccataaag gatgctagcc tgccttgtac taatgtttta tatattaaaa     4080

aaaaaaaatc tatcaaccat ttcatatata tcccactact caaggtatcc atggaacatg     4140

aaagaataac atttatgcag aggaaaaaca aaaacatccc tgaaaatata cacactcata     4200

cacacacacg cacaggggaa taaaataaga aaatcatttt cctcaccata gacttgatcc     4260

catccttaca acccatcctt ctaacttgat gtgtataaaa tatgcaaaca tttcacaaat     4320

gttctttgtc atttcaaaat actttagtat atcaatatca gtagatacca gtgggtggga     4380

aagggtcatt acatgaaaat atgaagaaat agccatatta gttttttaac ctgcaatttg     4440

cctcagcaac aaagaaaaag tgaattttta atgctgaaga taaagtaagc taaagtacca     4500

gcagaagcct tggctattta tagcagttct gacaatagtt ttataagaac atgaagagaa     4560

cagaatcact tgaaaatgga tgccagtcat ctcttgttcc cactactgaa ttcttataaa     4620

gtggtggcaa gatagggaag ggataatctg agaattttta aaagatgatt taatgagaag     4680

aagcacaatt ttgattttga tgagtcactt tctgtaaaca atcttggtct atctttaccc     4740

ttatacctta tctgtaattt accatttatt gtatttgcaa agctagtatg gtttttaatc     4800

acagtaaatc ctttgtattc cagactttag ggcagagccc tgagggagta ttattttaca     4860

taacccgtcc tagagtaaca ttttaggcaa cattcttcat tgcaagtaaa agatccataa     4920

gtggcatttt acacggctgc gagtattgtt atatctaatc ctattttaaa agatttttgg     4980

taatatgaag cttgaatact ggtaacagtg atgcaatata cgcaagctgc acaacctgta     5040

tattgtatgc attgctgcgt ggaggctgtt tatttcaacc tttttaaaaa ttgtgttttt     5100

tagtaaaatg gcttattttt tcccaaaggt ggaatttagc attttgtaat gatgaatata     5160

aaaatacctg tcatccccag atcatttaaa agttaactaa agtgagaatg aaaaaacaaa     5220

attccaagac actttttaaa agaatgtctg ccctcacaca cttttatgga tttgtttttc     5280

ttacataccc atcttttaac ttagagatag cattttttgc cctctttatt ttgttgtttg     5340

tttctccaga gagtaaacgc tttgtagttc tttctttaaa aaacattttt tttaaagaag     5400

aagaagccac ttgaaccctc aataaaggct gttgcctaag catggcatac ttcatctgtt     5460

ctcatttgtg ccatctgccg tgatgtcgtc acttttatgg cgttaatttc ctgccactac     5520

agatcttttg aagattgctg gaatactggt gtctgttaga atgcttcaga ctacagatgt     5580

aattaaaggc ttttcttaat atgttttaac caaagatgtg gagcaatcca agccacatat     5640

cttctacatc aaatttttcc attttggtta ttttcataat ctggtattgc attttgcctt     5700

ccctgttcat acctcaaatt gattcatacc tcagtttaat tcagagaggt cagttaagtg     5760

acggattctg ttgtggtttg aatgcagtac cagtgttctc ttcgagcaaa gtagacctgg     5820

gtcactgtag gcataggact tggattgctt cagatggttt gctgtatcat ttttcttctt     5880

tttcttttcc tggggacttg tttccattaa atgagagtaa ttaaaatcgc ttgtaaatga     5940

gggcatacaa gcatttgcaa caaatattca aatagaggct cacagcggca taagctggac     6000

tttgtcgcca ctagatgaca agatgttata actaagttaa accacatctg tgtatctcaa     6060

gggacttaat tcagctgtct gtagtgaata aaagtgggaa attttcaaaa gtttctcctg     6120

ctggaaataa ggtataattt gtattttgca gacaattcag taaagttact ggctttctta     6180

gtgaaaaaaa aaaa                                                       6194


