                         SEQUENCE LISTING

<110>  SERVICIO ANDALUZ DE SALUD
       FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD
       UNIVERSIDAD DE SEVILLA
 
<120>  Biomarcadores para la esclerosis lateral amiotrfica (ELA)

<130>  CABIMER-15004

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  2886
<212>  DNA
<213>  Homo sapiens

<400>  1
agattcctac ttcttacgcc ccccacatca cccgcctcga gacctcaagg gtagaggtgg       60

gcacccccgc ctccgcactt ttgctcgggg ctccagattg tagggcaggg cggcgcttct      120

cggaaagcga aagccggcgg ggcggggcgg gtgccgcagg agaaagagga agcgctggca      180

gacaatgcga cccgaccgcg ctgaggctcc aggaccgccc gccatggctg caggaggtcc      240

cggcgcgggg tctgcggccc cggtctcctc cacatcctcc cttcccctgg ctgctctcaa      300

catgcgagtg cggcgccgcc tgtctctgtt cttgaacgtg cggacacagg tggcggccga      360

ctggaccgcg ctggcggagg agatggactt tgagtacttg gagatccggc aactggagac      420

acaagcggac cccactggca ggctgctgga cgcctggcag ggacgccctg gcgcctctgt      480

aggccgactg ctcgagctgc ttaccaagct gggccgcgac gacgtgctgc tggagctggg      540

acccagcatt gaggaggatt gccaaaagta tatcttgaag cagcagcagg aggaggctga      600

gaagccttta caggtggccg ctgtagacag cagtgtccca cggacagcag agctggcggg      660

catcaccaca cttgatgacc ccctggggca tatgcctgag cgtttcgatg ccttcatctg      720

ctattgcccc agcgacatcc agtttgtgca ggagatgatc cggcaactgg aacagacaaa      780

ctatcgactg aagttgtgtg tgtctgaccg cgatgtcctg cctggcacct gtgtctggtc      840

tattgctagt gagctcatcg aaaagaggtt ggctagaagg ccacggggtg ggtgccgccg      900

gatggtggtg gttgtctctg atgattacct gcagagcaag gaatgtgact tccagaccaa      960

atttgcactc agcctctctc caggtgccca tcagaagcga ctgatcccca tcaagtacaa     1020

ggcaatgaag aaagagttcc ccagcatcct gaggttcatc actgtctgcg actacaccaa     1080

cccctgcacc aaatcttggt tctggactcg ccttgccaag gccttgtccc tgccctgaag     1140

actgttctga ggccctgggt gtgtgtgtat ctgtctgcct gtccatgtac ttctgccctg     1200

cctcctcctt tcgttgtagg aggaatctgt gctctactta cctctcaatt cctggagatg     1260

ccaacttcac agacacgtct gcagcagctg gacatcacat ttcatgtcct gcatggaacc     1320

agtggctgtg agtggcatgt ccacttgctg gattatcagc caggacacta tagaacagga     1380

ccagctgaga ctaagaagga ccagcagagc cagctcagct ctgagccatt cacacatctt     1440

caccctcagt ttcctcactt gaggagtggg atggggagaa cagagagtag ctgtgtttga     1500

atccctgtag gaaatggtga agcatagctc tgggtctcct gggggagacc aggcttggct     1560

gcgggagagc tggctgttgc tggactacat gctggccact gctgtgacca cgacactgct     1620

ggggcagctt cttccacagt gatgcctact gatgcttcag tgcctctgca caccgcccat     1680

tccacttcct ccttccccac agggcaggtg gggaagcagt ttggcccagc ccaaggagac     1740

cccaccttga gccttatttc ctaatgggtc cacctctcat ctgcatcttt cacacctccc     1800

agcttctgcc caaccttcag cagtgacaag tccccaagag actcgcctga gcagcttggg     1860

ctgcttttca tttccacctg tcaggatgcc tgtggtcatg ctctcagctc cacctggcat     1920

gagaagggat cctggcctct ggcatattca tcaagtatga gttctgggga tgagtcactg     1980

taatgatgtg agcagggagc cttcctccct gggccacctg cagagagctt tcccaccaac     2040

tttgtacctt gattgcctta caaagttatt tgtttacaaa cagcgaccat ataaaagcct     2100

cctgccccaa agcttgtggg cacatgggca catacagact cacatacaga cacacacata     2160

tatgtacaga catgtactct cacacacaca ggcaccagca tacacacgtt tttctaggta     2220

cagctcccag gaacagctag gtgggaaagt cccatcactg agggagccta accatgtccc     2280

tgaacaaaaa ttgggcactc atctattcct tttctcttgt gtccctactc attgaaacca     2340

aactctggaa aggacccaat gtaccagtat ttatacctct aatgaagcac agagagagga     2400

agagagctgc ttaaactcac acaacaatga actgcagaca cagctgttct ctccctctct     2460

ccttcccaga gcaatttata ctttaccctc aggctgtcct ctggggagaa ggtgccatgg     2520

tcttaggtgt ctgtgcccca ggacagaccc taggacccta aatccaatag aaaatgcata     2580

tctttgctcc actttcagcc aggctggagc aaggtacctt ttcttaggat cttgggaggg     2640

aatggatgcc cctctctgca tgatcttgtt gaggcattta gctgccatgc acctgtcccc     2700

ctttaatact gggcatttta aagccatctc aagaggcatc ttctacatgt tttgtacgca     2760

ttaaaataat ttcaaagata tctgagaaaa gccgatattt gccattcttc ctatatcctg     2820

gaatatatct tgcatcctga gtttataata ataaataata ttctaccttg gaaaaaaaaa     2880

aaaaaa                                                                2886


<210>  2
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Pro Asp Arg Ala Glu Ala Pro Gly Pro Pro Ala Met Ala Ala 
1               5                   10                  15      


Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser Thr Ser Ser 
            20                  25                  30          


Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg Leu Ser Leu 
        35                  40                  45              


Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr Ala Leu Ala 
    50                  55                  60                  


Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu Glu Thr Gln 
65                  70                  75                  80  


Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly Arg Pro Gly 
                85                  90                  95      


Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu Gly Arg Asp 
            100                 105                 110         


Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp Cys Gln Lys 
        115                 120                 125             


Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro Leu Gln Val 
    130                 135                 140                 


Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu Ala Gly Ile 
145                 150                 155                 160 


Thr Thr Leu Asp Asp Pro Leu Gly His Met Pro Glu Arg Phe Asp Ala 
                165                 170                 175     


Phe Ile Cys Tyr Cys Pro Ser Asp Ile Gln Phe Val Gln Glu Met Ile 
            180                 185                 190         


Arg Gln Leu Glu Gln Thr Asn Tyr Arg Leu Lys Leu Cys Val Ser Asp 
        195                 200                 205             


Arg Asp Val Leu Pro Gly Thr Cys Val Trp Ser Ile Ala Ser Glu Leu 
    210                 215                 220                 


Ile Glu Lys Arg Leu Ala Arg Arg Pro Arg Gly Gly Cys Arg Arg Met 
225                 230                 235                 240 


Val Val Val Val Ser Asp Asp Tyr Leu Gln Ser Lys Glu Cys Asp Phe 
                245                 250                 255     


Gln Thr Lys Phe Ala Leu Ser Leu Ser Pro Gly Ala His Gln Lys Arg 
            260                 265                 270         


Leu Ile Pro Ile Lys Tyr Lys Ala Met Lys Lys Glu Phe Pro Ser Ile 
        275                 280                 285             


Leu Arg Phe Ile Thr Val Cys Asp Tyr Thr Asn Pro Cys Thr Lys Ser 
    290                 295                 300                 


Trp Phe Trp Thr Arg Leu Ala Lys Ala Leu Ser Leu Pro 
305                 310                 315         


<210>  3
<211>  2862
<212>  DNA
<213>  Homo sapiens

<400>  3
agattcctac ttcttacgcc ccccacatca cccgcctcga gacctcaagg gtagaggtgg       60

gcacccccgc ctccgcactt ttgctcgggg ctccagattg tagggcaggg cggcgcttct      120

cggaaagcga aagccggcgg ggcggggcgg gtgccgcagg agaaagagga agcgctggca      180

gacaatgcga cccgaccgcg ctgaggctcc aggaccgccc gccatggctg caggaggtcc      240

cggcgcgggg tctgcggccc cggtctcctc cacatcctcc cttcccctgg ctgctctcaa      300

catgcgagtg cggcgccgcc tgtctctgtt cttgaacgtg cggacacagg tggcggccga      360

ctggaccgcg ctggcggagg agatggactt tgagtacttg gagatccggc aactggagac      420

acaagcggac cccactggca ggctgctgga cgcctggcag ggacgccctg gcgcctctgt      480

aggccgactg ctcgagctgc ttaccaagct gggccgcgac gacgtgctgc tggagctggg      540

acccagcatt gaggaggatt gccaaaagta tatcttgaag cagcagcagg aggaggctga      600

gaagccttta caggtggccg ctgtagacag cagtgtccca cggacagcag agctggcggg      660

catcaccaca cttgatgacc ccctggggca tatgcctgag cgtttcgatg ccttcatctg      720

ctattgcccc agcgacatcc agtttgtgca ggagatgatc cggcaactgg aacagacaaa      780

ctatcgactg aagttgtgtg tgtctgaccg cgatgtcctg cctggcacct gtgtctggtc      840

tattgctagt gagctcatcg aaaagaggtg ccgccggatg gtggtggttg tctctgatga      900

ttacctgcag agcaaggaat gtgacttcca gaccaaattt gcactcagcc tctctccagg      960

tgcccatcag aagcgactga tccccatcaa gtacaaggca atgaagaaag agttccccag     1020

catcctgagg ttcatcactg tctgcgacta caccaacccc tgcaccaaat cttggttctg     1080

gactcgcctt gccaaggcct tgtccctgcc ctgaagactg ttctgaggcc ctgggtgtgt     1140

gtgtatctgt ctgcctgtcc atgtacttct gccctgcctc ctcctttcgt tgtaggagga     1200

atctgtgctc tacttacctc tcaattcctg gagatgccaa cttcacagac acgtctgcag     1260

cagctggaca tcacatttca tgtcctgcat ggaaccagtg gctgtgagtg gcatgtccac     1320

ttgctggatt atcagccagg acactataga acaggaccag ctgagactaa gaaggaccag     1380

cagagccagc tcagctctga gccattcaca catcttcacc ctcagtttcc tcacttgagg     1440

agtgggatgg ggagaacaga gagtagctgt gtttgaatcc ctgtaggaaa tggtgaagca     1500

tagctctggg tctcctgggg gagaccaggc ttggctgcgg gagagctggc tgttgctgga     1560

ctacatgctg gccactgctg tgaccacgac actgctgggg cagcttcttc cacagtgatg     1620

cctactgatg cttcagtgcc tctgcacacc gcccattcca cttcctcctt ccccacaggg     1680

caggtgggga agcagtttgg cccagcccaa ggagacccca ccttgagcct tatttcctaa     1740

tgggtccacc tctcatctgc atctttcaca cctcccagct tctgcccaac cttcagcagt     1800

gacaagtccc caagagactc gcctgagcag cttgggctgc ttttcatttc cacctgtcag     1860

gatgcctgtg gtcatgctct cagctccacc tggcatgaga agggatcctg gcctctggca     1920

tattcatcaa gtatgagttc tggggatgag tcactgtaat gatgtgagca gggagccttc     1980

ctccctgggc cacctgcaga gagctttccc accaactttg taccttgatt gccttacaaa     2040

gttatttgtt tacaaacagc gaccatataa aagcctcctg ccccaaagct tgtgggcaca     2100

tgggcacata cagactcaca tacagacaca cacatatatg tacagacatg tactctcaca     2160

cacacaggca ccagcataca cacgtttttc taggtacagc tcccaggaac agctaggtgg     2220

gaaagtccca tcactgaggg agcctaacca tgtccctgaa caaaaattgg gcactcatct     2280

attccttttc tcttgtgtcc ctactcattg aaaccaaact ctggaaagga cccaatgtac     2340

cagtatttat acctctaatg aagcacagag agaggaagag agctgcttaa actcacacaa     2400

caatgaactg cagacacagc tgttctctcc ctctctcctt cccagagcaa tttatacttt     2460

accctcaggc tgtcctctgg ggagaaggtg ccatggtctt aggtgtctgt gccccaggac     2520

agaccctagg accctaaatc caatagaaaa tgcatatctt tgctccactt tcagccaggc     2580

tggagcaagg taccttttct taggatcttg ggagggaatg gatgcccctc tctgcatgat     2640

cttgttgagg catttagctg ccatgcacct gtcccccttt aatactgggc attttaaagc     2700

catctcaaga ggcatcttct acatgttttg tacgcattaa aataatttca aagatatctg     2760

agaaaagccg atatttgcca ttcttcctat atcctggaat atatcttgca tcctgagttt     2820

ataataataa ataatattct accttggaaa aaaaaaaaaa aa                        2862


<210>  4
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Pro Asp Arg Ala Glu Ala Pro Gly Pro Pro Ala Met Ala Ala 
1               5                   10                  15      


Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser Thr Ser Ser 
            20                  25                  30          


Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg Leu Ser Leu 
        35                  40                  45              


Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr Ala Leu Ala 
    50                  55                  60                  


Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu Glu Thr Gln 
65                  70                  75                  80  


Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly Arg Pro Gly 
                85                  90                  95      


Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu Gly Arg Asp 
            100                 105                 110         


Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp Cys Gln Lys 
        115                 120                 125             


Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro Leu Gln Val 
    130                 135                 140                 


Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu Ala Gly Ile 
145                 150                 155                 160 


Thr Thr Leu Asp Asp Pro Leu Gly His Met Pro Glu Arg Phe Asp Ala 
                165                 170                 175     


Phe Ile Cys Tyr Cys Pro Ser Asp Ile Gln Phe Val Gln Glu Met Ile 
            180                 185                 190         


Arg Gln Leu Glu Gln Thr Asn Tyr Arg Leu Lys Leu Cys Val Ser Asp 
        195                 200                 205             


Arg Asp Val Leu Pro Gly Thr Cys Val Trp Ser Ile Ala Ser Glu Leu 
    210                 215                 220                 


Ile Glu Lys Arg Cys Arg Arg Met Val Val Val Val Ser Asp Asp Tyr 
225                 230                 235                 240 


Leu Gln Ser Lys Glu Cys Asp Phe Gln Thr Lys Phe Ala Leu Ser Leu 
                245                 250                 255     


Ser Pro Gly Ala His Gln Lys Arg Leu Ile Pro Ile Lys Tyr Lys Ala 
            260                 265                 270         


Met Lys Lys Glu Phe Pro Ser Ile Leu Arg Phe Ile Thr Val Cys Asp 
        275                 280                 285             


Tyr Thr Asn Pro Cys Thr Lys Ser Trp Phe Trp Thr Arg Leu Ala Lys 
    290                 295                 300                 


Ala Leu Ser Leu Pro 
305                 


<210>  5
<211>  2681
<212>  DNA
<213>  Homo sapiens

<400>  5
agattcctac ttcttacgcc ccccacatca cccgcctcga gacctcaagg gtagaggtgg       60

gcacccccgc ctccgcactt ttgctcgggg ctccagattg tagggcaggg cggcgcttct      120

cggaaagcga aagccggcgg ggcggggcgg gtgccgcagg agaaagagga agcgctggca      180

gacaatgcga cccgaccgcg ctgaggctcc aggaccgccc gccatggctg caggaggtcc      240

cggcgcgggg tctgcggccc cggtctcctc cacatcctcc cttcccctgg ctgctctcaa      300

catgcgagtg cggcgccgcc tgtctctgtt cttgaacgtg cggacacagg tggcggccga      360

ctggaccgcg ctggcggagg agatggactt tgagtacttg gagatccggc aactggagac      420

acaagcggac cccactggca ggctgctgga cgcctggcag ggacgccctg gcgcctctgt      480

aggccgactg ctcgagctgc ttaccaagct gggccgcgac gacgtgctgc tggagctggg      540

acccagcatt gaggaggatt gccaaaagta tatcttgaag cagcagcagg aggaggctga      600

gaagccttta caggtggccg ctgtagacag cagtgtccca cggacagcag agctggcggg      660

catcaccaca cttgatgacc ccctgggtgc cgccggatgg tggtggttgt ctctgatgat      720

tacctgcaga gcaaggaatg tgacttccag accaaatttg cactcagcct ctctccaggt      780

gcccatcaga agcgactgat ccccatcaag tacaaggcaa tgaagaaaga gttccccagc      840

atcctgaggt tcatcactgt ctgcgactac accaacccct gcaccaaatc ttggttctgg      900

actcgccttg ccaaggcctt gtccctgccc tgaagactgt tctgaggccc tgggtgtgtg      960

tgtatctgtc tgcctgtcca tgtacttctg ccctgcctcc tcctttcgtt gtaggaggaa     1020

tctgtgctct acttacctct caattcctgg agatgccaac ttcacagaca cgtctgcagc     1080

agctggacat cacatttcat gtcctgcatg gaaccagtgg ctgtgagtgg catgtccact     1140

tgctggatta tcagccagga cactatagaa caggaccagc tgagactaag aaggaccagc     1200

agagccagct cagctctgag ccattcacac atcttcaccc tcagtttcct cacttgagga     1260

gtgggatggg gagaacagag agtagctgtg tttgaatccc tgtaggaaat ggtgaagcat     1320

agctctgggt ctcctggggg agaccaggct tggctgcggg agagctggct gttgctggac     1380

tacatgctgg ccactgctgt gaccacgaca ctgctggggc agcttcttcc acagtgatgc     1440

ctactgatgc ttcagtgcct ctgcacaccg cccattccac ttcctccttc cccacagggc     1500

aggtggggaa gcagtttggc ccagcccaag gagaccccac cttgagcctt atttcctaat     1560

gggtccacct ctcatctgca tctttcacac ctcccagctt ctgcccaacc ttcagcagtg     1620

acaagtcccc aagagactcg cctgagcagc ttgggctgct tttcatttcc acctgtcagg     1680

atgcctgtgg tcatgctctc agctccacct ggcatgagaa gggatcctgg cctctggcat     1740

attcatcaag tatgagttct ggggatgagt cactgtaatg atgtgagcag ggagccttcc     1800

tccctgggcc acctgcagag agctttccca ccaactttgt accttgattg ccttacaaag     1860

ttatttgttt acaaacagcg accatataaa agcctcctgc cccaaagctt gtgggcacat     1920

gggcacatac agactcacat acagacacac acatatatgt acagacatgt actctcacac     1980

acacaggcac cagcatacac acgtttttct aggtacagct cccaggaaca gctaggtggg     2040

aaagtcccat cactgaggga gcctaaccat gtccctgaac aaaaattggg cactcatcta     2100

ttccttttct cttgtgtccc tactcattga aaccaaactc tggaaaggac ccaatgtacc     2160

agtatttata cctctaatga agcacagaga gaggaagaga gctgcttaaa ctcacacaac     2220

aatgaactgc agacacagct gttctctccc tctctccttc ccagagcaat ttatacttta     2280

ccctcaggct gtcctctggg gagaaggtgc catggtctta ggtgtctgtg ccccaggaca     2340

gaccctagga ccctaaatcc aatagaaaat gcatatcttt gctccacttt cagccaggct     2400

ggagcaaggt accttttctt aggatcttgg gagggaatgg atgcccctct ctgcatgatc     2460

ttgttgaggc atttagctgc catgcacctg tcccccttta atactgggca ttttaaagcc     2520

atctcaagag gcatcttcta catgttttgt acgcattaaa ataatttcaa agatatctga     2580

gaaaagccga tatttgccat tcttcctata tcctggaata tatcttgcat cctgagttta     2640

taataataaa taatattcta ccttggaaaa aaaaaaaaaa a                         2681


<210>  6
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Arg Pro Asp Arg Ala Glu Ala Pro Gly Pro Pro Ala Met Ala Ala 
1               5                   10                  15      


Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser Thr Ser Ser 
            20                  25                  30          


Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg Leu Ser Leu 
        35                  40                  45              


Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr Ala Leu Ala 
    50                  55                  60                  


Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu Glu Thr Gln 
65                  70                  75                  80  


Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly Arg Pro Gly 
                85                  90                  95      


Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu Gly Arg Asp 
            100                 105                 110         


Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp Cys Gln Lys 
        115                 120                 125             


Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro Leu Gln Val 
    130                 135                 140                 


Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu Ala Gly Ile 
145                 150                 155                 160 


Thr Thr Leu Asp Asp Pro Leu Gly Ala Ala Gly Trp Trp Trp Leu Ser 
                165                 170                 175     


Leu Met Ile Thr Cys Arg Ala Arg Asn Val Thr Ser Arg Pro Asn Leu 
            180                 185                 190         


His Ser Ala Ser Leu Gln Val Pro Ile Arg Ser Asp 
        195                 200                 


<210>  7
<211>  2727
<212>  DNA
<213>  SEQ ID NO: 7

<400>  7
agattcctac ttcttacgcc ccccacatca cccgcctcga gacctcaagg gtagaggtgg       60

gcacccccgc ctccgcactt ttgctcgggg ctccagattg tagggcaggg cggcgcttct      120

cggaaagcga aagccggcgg ggcggggcgg gtgccgcagg agaaagagga agcgctggca      180

gacaatgcga cccgaccgcg ctgaggctcc aggaccgccc gccatggctg caggaggtcc      240

cggcgcgggg tctgcggccc cggtctcctc cacatcctcc cttcccctgg ctgctctcaa      300

catgcgagtg cggcgccgcc tgtctctgtt cttgaacgtg cggacacagg tggcggccga      360

ctggaccgcg ctggcggagg agatggactt tgagtacttg gagatccggc aactggagac      420

acaagcggac cccactggca ggctgctgga cgcctggcag ggacgccctg gcgcctctgt      480

aggccgactg ctcgagctgc ttaccaagct gggccgcgac gacgtgctgc tggagctggg      540

acccagcatt gggcatatgc ctgagcgttt cgatgccttc atctgctatt gccccagcga      600

catccagttt gtgcaggaga tgatccggca actggaacag acaaactatc gactgaagtt      660

gtgtgtgtct gaccgcgatg tcctgcctgg cacctgtgtc tggtctattg ctagtgagct      720

catcgaaaag aggtgccgcc ggatggtggt ggttgtctct gatgattacc tgcagagcaa      780

ggaatgtgac ttccagacca aatttgcact cagcctctct ccaggtgccc atcagaagcg      840

actgatcccc atcaagtaca aggcaatgaa gaaagagttc cccagcatcc tgaggttcat      900

cactgtctgc gactacacca acccctgcac caaatcttgg ttctggactc gccttgccaa      960

ggccttgtcc ctgccctgaa gactgttctg aggccctggg tgtgtgtgta tctgtctgcc     1020

tgtccatgta cttctgccct gcctcctcct ttcgttgtag gaggaatctg tgctctactt     1080

acctctcaat tcctggagat gccaacttca cagacacgtc tgcagcagct ggacatcaca     1140

tttcatgtcc tgcatggaac cagtggctgt gagtggcatg tccacttgct ggattatcag     1200

ccaggacact atagaacagg accagctgag actaagaagg accagcagag ccagctcagc     1260

tctgagccat tcacacatct tcaccctcag tttcctcact tgaggagtgg gatggggaga     1320

acagagagta gctgtgtttg aatccctgta ggaaatggtg aagcatagct ctgggtctcc     1380

tgggggagac caggcttggc tgcgggagag ctggctgttg ctggactaca tgctggccac     1440

tgctgtgacc acgacactgc tggggcagct tcttccacag tgatgcctac tgatgcttca     1500

gtgcctctgc acaccgccca ttccacttcc tccttcccca cagggcaggt ggggaagcag     1560

tttggcccag cccaaggaga ccccaccttg agccttattt cctaatgggt ccacctctca     1620

tctgcatctt tcacacctcc cagcttctgc ccaaccttca gcagtgacaa gtccccaaga     1680

gactcgcctg agcagcttgg gctgcttttc atttccacct gtcaggatgc ctgtggtcat     1740

gctctcagct ccacctggca tgagaaggga tcctggcctc tggcatattc atcaagtatg     1800

agttctgggg atgagtcact gtaatgatgt gagcagggag ccttcctccc tgggccacct     1860

gcagagagct ttcccaccaa ctttgtacct tgattgcctt acaaagttat ttgtttacaa     1920

acagcgacca tataaaagcc tcctgcccca aagcttgtgg gcacatgggc acatacagac     1980

tcacatacag acacacacat atatgtacag acatgtactc tcacacacac aggcaccagc     2040

atacacacgt ttttctaggt acagctccca ggaacagcta ggtgggaaag tcccatcact     2100

gagggagcct aaccatgtcc ctgaacaaaa attgggcact catctattcc ttttctcttg     2160

tgtccctact cattgaaacc aaactctgga aaggacccaa tgtaccagta tttatacctc     2220

taatgaagca cagagagagg aagagagctg cttaaactca cacaacaatg aactgcagac     2280

acagctgttc tctccctctc tccttcccag agcaatttat actttaccct caggctgtcc     2340

tctggggaga aggtgccatg gtcttaggtg tctgtgcccc aggacagacc ctaggaccct     2400

aaatccaata gaaaatgcat atctttgctc cactttcagc caggctggag caaggtacct     2460

tttcttagga tcttgggagg gaatggatgc ccctctctgc atgatcttgt tgaggcattt     2520

agctgccatg cacctgtccc cctttaatac tgggcatttt aaagccatct caagaggcat     2580

cttctacatg ttttgtacgc attaaaataa tttcaaagat atctgagaaa agccgatatt     2640

tgccattctt cctatatcct ggaatatatc ttgcatcctg agtttataat aataaataat     2700

attctacctt ggaaaaaaaa aaaaaaa                                         2727


<210>  8
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Arg Pro Asp Arg Ala Glu Ala Pro Gly Pro Pro Ala Met Ala Ala 
1               5                   10                  15      


Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser Thr Ser Ser 
            20                  25                  30          


Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg Leu Ser Leu 
        35                  40                  45              


Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr Ala Leu Ala 
    50                  55                  60                  


Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu Glu Thr Gln 
65                  70                  75                  80  


Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly Arg Pro Gly 
                85                  90                  95      


Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu Gly Arg Asp 
            100                 105                 110         


Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Gly His Met Pro Glu Arg 
        115                 120                 125             


Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp Ile Gln Phe Val Gln 
    130                 135                 140                 


Glu Met Ile Arg Gln Leu Glu Gln Thr Asn Tyr Arg Leu Lys Leu Cys 
145                 150                 155                 160 


Val Ser Asp Arg Asp Val Leu Pro Gly Thr Cys Val Trp Ser Ile Ala 
                165                 170                 175     


Ser Glu Leu Ile Glu Lys Arg Cys Arg Arg Met Val Val Val Val Ser 
            180                 185                 190         


Asp Asp Tyr Leu Gln Ser Lys Glu Cys Asp Phe Gln Thr Lys Phe Ala 
        195                 200                 205             


Leu Ser Leu Ser Pro Gly Ala His Gln Lys Arg Leu Ile Pro Ile Lys 
    210                 215                 220                 


Tyr Lys Ala Met Lys Lys Glu Phe Pro Ser Ile Leu Arg Phe Ile Thr 
225                 230                 235                 240 


Val Cys Asp Tyr Thr Asn Pro Cys Thr Lys Ser Trp Phe Trp Thr Arg 
                245                 250                 255     


Leu Ala Lys Ala Leu Ser Leu Pro 
            260                 


<210>  9
<211>  2546
<212>  DNA
<213>  Homo sapiens

<400>  9
agattcctac ttcttacgcc ccccacatca cccgcctcga gacctcaagg gtagaggtgg       60

gcacccccgc ctccgcactt ttgctcgggg ctccagattg tagggcaggg cggcgcttct      120

cggaaagcga aagccggcgg ggcggggcgg gtgccgcagg agaaagagga agcgctggca      180

gacaatgcga cccgaccgcg ctgaggctcc aggaccgccc gccatggctg caggaggtcc      240

cggcgcgggg tctgcggccc cggtctcctc cacatcctcc cttcccctgg ctgctctcaa      300

catgcgagtg cggcgccgcc tgtctctgtt cttgaacgtg cggacacagg tggcggccga      360

ctggaccgcg ctggcggagg agatggactt tgagtacttg gagatccggc aactggagac      420

acaagcggac cccactggca ggctgctgga cgcctggcag ggacgccctg gcgcctctgt      480

aggccgactg ctcgagctgc ttaccaagct gggccgcgac gacgtgctgc tggagctggg      540

acccagcatt ggtgccgccg gatggtggtg gttgtctctg atgattacct gcagagcaag      600

gaatgtgact tccagaccaa atttgcactc agcctctctc caggtgccca tcagaagcga      660

ctgatcccca tcaagtacaa ggcaatgaag aaagagttcc ccagcatcct gaggttcatc      720

actgtctgcg actacaccaa cccctgcacc aaatcttggt tctggactcg ccttgccaag      780

gccttgtccc tgccctgaag actgttctga ggccctgggt gtgtgtgtat ctgtctgcct      840

gtccatgtac ttctgccctg cctcctcctt tcgttgtagg aggaatctgt gctctactta      900

cctctcaatt cctggagatg ccaacttcac agacacgtct gcagcagctg gacatcacat      960

ttcatgtcct gcatggaacc agtggctgtg agtggcatgt ccacttgctg gattatcagc     1020

caggacacta tagaacagga ccagctgaga ctaagaagga ccagcagagc cagctcagct     1080

ctgagccatt cacacatctt caccctcagt ttcctcactt gaggagtggg atggggagaa     1140

cagagagtag ctgtgtttga atccctgtag gaaatggtga agcatagctc tgggtctcct     1200

gggggagacc aggcttggct gcgggagagc tggctgttgc tggactacat gctggccact     1260

gctgtgacca cgacactgct ggggcagctt cttccacagt gatgcctact gatgcttcag     1320

tgcctctgca caccgcccat tccacttcct ccttccccac agggcaggtg gggaagcagt     1380

ttggcccagc ccaaggagac cccaccttga gccttatttc ctaatgggtc cacctctcat     1440

ctgcatcttt cacacctccc agcttctgcc caaccttcag cagtgacaag tccccaagag     1500

actcgcctga gcagcttggg ctgcttttca tttccacctg tcaggatgcc tgtggtcatg     1560

ctctcagctc cacctggcat gagaagggat cctggcctct ggcatattca tcaagtatga     1620

gttctgggga tgagtcactg taatgatgtg agcagggagc cttcctccct gggccacctg     1680

cagagagctt tcccaccaac tttgtacctt gattgcctta caaagttatt tgtttacaaa     1740

cagcgaccat ataaaagcct cctgccccaa agcttgtggg cacatgggca catacagact     1800

cacatacaga cacacacata tatgtacaga catgtactct cacacacaca ggcaccagca     1860

tacacacgtt tttctaggta cagctcccag gaacagctag gtgggaaagt cccatcactg     1920

agggagccta accatgtccc tgaacaaaaa ttgggcactc atctattcct tttctcttgt     1980

gtccctactc attgaaacca aactctggaa aggacccaat gtaccagtat ttatacctct     2040

aatgaagcac agagagagga agagagctgc ttaaactcac acaacaatga actgcagaca     2100

cagctgttct ctccctctct ccttcccaga gcaatttata ctttaccctc aggctgtcct     2160

ctggggagaa ggtgccatgg tcttaggtgt ctgtgcccca ggacagaccc taggacccta     2220

aatccaatag aaaatgcata tctttgctcc actttcagcc aggctggagc aaggtacctt     2280

ttcttaggat cttgggaggg aatggatgcc cctctctgca tgatcttgtt gaggcattta     2340

gctgccatgc acctgtcccc ctttaatact gggcatttta aagccatctc aagaggcatc     2400

ttctacatgt tttgtacgca ttaaaataat ttcaaagata tctgagaaaa gccgatattt     2460

gccattcttc ctatatcctg gaatatatct tgcatcctga gtttataata ataaataata     2520

ttctaccttg gaaaaaaaaa aaaaaa                                          2546


<210>  10
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Arg Pro Asp Arg Ala Glu Ala Pro Gly Pro Pro Ala Met Ala Ala 
1               5                   10                  15      


Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser Thr Ser Ser 
            20                  25                  30          


Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg Leu Ser Leu 
        35                  40                  45              


Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr Ala Leu Ala 
    50                  55                  60                  


Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu Glu Thr Gln 
65                  70                  75                  80  


Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly Arg Pro Gly 
                85                  90                  95      


Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu Gly Arg Asp 
            100                 105                 110         


Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Gly Ala Ala Gly Trp Trp 
        115                 120                 125             


Trp Leu Ser Leu Met Ile Thr Cys Arg Ala Arg Asn Val Thr Ser Arg 
    130                 135                 140                 


Pro Asn Leu His Ser Ala Ser Leu Gln Val Pro Ile Arg Ser Asp 
145                 150                 155                 


<210>  11
<211>  2826
<212>  DNA
<213>  Homo sapiens

<400>  11
cctacttctt acgcccccca catcacccgc ctcgagacct caagggtaga ggtgggcacc       60

cccgcctccg cacttttgct cggggctcca gattgtaggg cagggcggcg cttctcggaa      120

agcgaaagcc ggcggggcgg ggcgggtgcc gcaggagaaa gaggaagcgc tggcagacaa      180

tgcgacccga ccgcgctgag gctccaggac cgcccgccat ggctgcagga ggtcccggcg      240

cggggtctgc ggccccggtc tcctccacat cctcccttcc cctggctgct ctcaacatgc      300

gagtgcggcg ccgcctgtct ctgttcttga acgtgcggac acaggtggcg gccgactgga      360

ccgcgctggc ggaggagatg gactttgagt acttggagat ccggcaactg gagacacaag      420

cggaccccac tggcaggctg ctggacgcct ggcagggacg ccctggcgcc tctgtaggcc      480

gactgctcga gctgcttacc aagctgggcc gcgacgacgt gctgctggag ctgggaccca      540

gcattgagga ggattgccaa aagtatatct tgaagcagca gcaggaggag gctgagaagc      600

ctttacaggt ggccgctgta gacagcagtg tcccacggac agcagagctg gcgggcatca      660

ccacacttga tgaccccctg gggcatatgc ctgagcgttt cgatgccttc atctgctatt      720

gccccagcga catccagttt gtgcaggaga tgatccggca actggaacag acaaactatc      780

gactgaagtt gtgtgtgtct gaccgcgatg tcctgcctgg cacctgtgtc tggtctattg      840

ctagtgccgc cggatggtgg tggttgtctc tgatgattac ctgcagagca aggaatgtga      900

cttccagacc aaatttgcac tcagcctctc tccaggtgcc catcagaagc gactgatccc      960

catcaagtac aaggcaatga agaaagagtt ccccagcatc ctgaggttca tcactgtctg     1020

cgactacacc aacccctgca ccaaatcttg gttctggact cgccttgcca aggccttgtc     1080

cctgccctga agactgttct gaggccctgg gtgtgtgtgt atctgtctgc ctgtccatgt     1140

acttctgccc tgcctcctcc tttcgttgta ggaggaatct gtgctctact tacctctcaa     1200

ttcctggaga tgccaacttc acagacacgt ctgcagcagc tggacatcac atttcatgtc     1260

ctgcatggaa ccagtggctg tgagtggcat gtccacttgc tggattatca gccaggacac     1320

tatagaacag gaccagctga gactaagaag gaccagcaga gccagctcag ctctgagcca     1380

ttcacacatc ttcaccctca gtttcctcac ttgaggagtg ggatggggag aacagagagt     1440

agctgtgttt gaatccctgt aggaaatggt gaagcatagc tctgggtctc ctgggggaga     1500

ccaggcttgg ctgcgggaga gctggctgtt gctggactac atgctggcca ctgctgtgac     1560

cacgacactg ctggggcagc ttcttccaca gtgatgccta ctgatgcttc agtgcctctg     1620

cacaccgccc attccacttc ctccttcccc acagggcagg tggggaagca gtttggccca     1680

gcccaaggag accccacctt gagccttatt tcctaatggg tccacctctc atctgcatct     1740

ttcacacctc ccagcttctg cccaaccttc agcagtgaca agtccccaag agactcgcct     1800

gagcagcttg ggctgctttt catttccacc tgtcaggatg cctgtggtca tgctctcagc     1860

tccacctggc atgagaaggg atcctggcct ctggcatatt catcaagtat gagttctggg     1920

gatgagtcac tgtaatgatg tgagcaggga gccttcctcc ctgggccacc tgcagagagc     1980

tttcccacca actttgtacc ttgattgcct tacaaagtta tttgtttaca aacagcgacc     2040

atataaaagc ctcctgcccc aaagcttgtg ggcacatggg cacatacaga ctcacataca     2100

gacacacaca tatatgtaca gacatgtact ctcacacaca caggcaccag catacacacg     2160

tttttctagg tacagctccc aggaacagct aggtgggaaa gtcccatcac tgagggagcc     2220

taaccatgtc cctgaacaaa aattgggcac tcatctattc cttttctctt gtgtccctac     2280

tcattgaaac caaactctgg aaaggaccca atgtaccagt atttatacct ctaatgaagc     2340

acagagagag gaagagagct gcttaaactc acacaacaat gaactgcaga cacagctgtt     2400

ctctccctct ctccttccca gagcaattta tactttaccc tcaggctgtc ctctggggag     2460

aaggtgccat ggtcttaggt gtctgtgccc caggacagac cctaggaccc taaatccaat     2520

agaaaatgca tatctttgct ccactttcag ccaggctgga gcaaggtacc ttttcttagg     2580

atcttgggag ggaatggatg cccctctctg catgatcttg ttgaggcatt tagctgccat     2640

gcacctgtcc ccctttaata ctgggcattt taaagccatc tcaagaggca tcttctacat     2700

gttttgtacg cattaaaata atttcaaaga tatctgagaa aagccgatat ttgccattct     2760

tcctatatcc tggaatatat cttgcatcct gagtttataa taataaataa tattctacct     2820

tggaaa                                                                2826


<210>  12
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Arg Pro Asp Arg Ala Glu Ala Pro Gly Pro Pro Ala Met Ala Ala 
1               5                   10                  15      


Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser Thr Ser Ser 
            20                  25                  30          


Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg Leu Ser Leu 
        35                  40                  45              


Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr Ala Leu Ala 
    50                  55                  60                  


Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu Glu Thr Gln 
65                  70                  75                  80  


Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly Arg Pro Gly 
                85                  90                  95      


Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu Gly Arg Asp 
            100                 105                 110         


Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp Cys Gln Lys 
        115                 120                 125             


Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro Leu Gln Val 
    130                 135                 140                 


Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu Ala Gly Ile 
145                 150                 155                 160 


Thr Thr Leu Asp Asp Pro Leu Gly His Met Pro Glu Arg Phe Asp Ala 
                165                 170                 175     


Phe Ile Cys Tyr Cys Pro Ser Asp Ile Gln Phe Val Gln Glu Met Ile 
            180                 185                 190         


Arg Gln Leu Glu Gln Thr Asn Tyr Arg Leu Lys Leu Cys Val Ser Asp 
        195                 200                 205             


Arg Asp Val Leu Pro Gly Thr Cys Val Trp Ser Ile Ala Ser Ala Ala 
    210                 215                 220                 


Gly Trp Trp Trp Leu Ser Leu Met Ile Thr Cys Arg Ala Arg Asn Val 
225                 230                 235                 240 


Thr Ser Arg Pro Asn Leu His Ser Ala Ser Leu Gln Val Pro Ile Arg 
                245                 250                 255     


Ser Asp 
        


<210>  13
<211>  2517
<212>  DNA
<213>  Homo sapiens

<400>  13
agacaatgcg acccgaccgc gctgaggctc caggaccgcc cgccatggct gcaggaggtc       60

ccggcgcggg gtctgcggcc ccggtctcct ccacatcctc ccttcccctg gctgctctca      120

acatgcgagt gcggcgccgc ctgtctctgt tcttgaacgt gcggacacag gtggcggccg      180

actggaccgc gctggcggag gagatggact ttgagtactt ggagatccgg caactggaga      240

cacaagcgga ccccactggc aggctgctgg acgcctggca gggacgccct ggcgcctctg      300

taggccgact gctcgagctg cttaccaagc tgggccgcga cgacgtgctg ctggagctgg      360

gacccagcat tgggcatatg cctgagcgtt tcgatgcctt catctgctat tgccccagcg      420

acatccagtt tgtgcaggag atgatccggc aactggaaca gacaaactat cgactgaagt      480

tgtgtgtgtc tgaccgcgat gtcctgcctg gcacctgtgt ctggtctatt gctagtgccg      540

ccggatggtg gtggttgtct ctgatgatta cctgcagagc aaggaatgtg acttccagac      600

caaatttgca ctcagcctct ctccaggtgc ccatcagaag cgactgatcc ccatcaagta      660

caaggcaatg aagaaagagt tccccagcat cctgaggttc atcactgtct gcgactacac      720

caacccctgc accaaatctt ggttctggac tcgccttgcc aaggccttgt ccctgccctg      780

aagactgttc tgaggccctg ggtgtgtgtg tatctgtctg cctgtccatg tacttctgcc      840

ctgcctcctc ctttcgttgt aggaggaatc tgtgctctac ttacctctca attcctggag      900

atgccaactt cacagacacg tctgcagcag ctggacatca catttcatgt cctgcatgga      960

accagtggct gtgagtggca tgtccacttg ctggattatc agccaggaca ctatagaaca     1020

ggaccagctg agactaagaa ggaccagcag agccagctca gctctgagcc attcacacat     1080

cttcaccctc agtttcctca cttgaggagt gggatgggga gaacagagag tagctgtgtt     1140

tgaatccctg taggaaatgg tgaagcatag ctctgggtct cctgggggag accaggcttg     1200

gctgcgggag agctggctgt tgctggacta catgctggcc actgctgtga ccacgacact     1260

gctggggcag cttcttccac agtgatgcct actgatgctt cagtgcctct gcacaccgcc     1320

cattccactt cctccttccc cacagggcag gtggggaagc agtttggccc agcccaagga     1380

gaccccacct tgagccttat ttcctaatgg gtccacctct catctgcatc tttcacacct     1440

cccagcttct gcccaacctt cagcagtgac aagtccccaa gagactcgcc tgagcagctt     1500

gggctgcttt tcatttccac ctgtcaggat gcctgtggtc atgctctcag ctccacctgg     1560

catgagaagg gatcctggcc tctggcatat tcatcaagta tgagttctgg ggatgagtca     1620

ctgtaatgat gtgagcaggg agccttcctc cctgggccac ctgcagagag ctttcccacc     1680

aactttgtac cttgattgcc ttacaaagtt atttgtttac aaacagcgac catataaaag     1740

cctcctgccc caaagcttgt gggcacatgg gcacatacag actcacatac agacacacac     1800

atatatgtac agacatgtac tctcacacac acaggcacca gcatacacac gtttttctag     1860

gtacagctcc caggaacagc taggtgggaa agtcccatca ctgagggagc ctaaccatgt     1920

ccctgaacaa aaattgggca ctcatctatt ccttttctct tgtgtcccta ctcattgaaa     1980

ccaaactctg gaaaggaccc aatgtaccag tatttatacc tctaatgaag cacagagaga     2040

ggaagagagc tgcttaaact cacacaacaa tgaactgcag acacagctgt tctctccctc     2100

tctccttccc agagcaattt atactttacc ctcaggctgt cctctgggga gaaggtgcca     2160

tggtcttagg tgtctgtgcc ccaggacaga ccctaggacc ctaaatccaa tagaaaatgc     2220

atatctttgc tccactttca gccaggctgg agcaaggtac cttttcttag gatcttggga     2280

gggaatggat gcccctctct gcatgatctt gttgaggcat ttagctgcca tgcacctgtc     2340

cccctttaat actgggcatt ttaaagccat ctcaagaggc atcttctaca tgttttgtac     2400

gcattaaaat aatttcaaag atatctgaga aaagccgata tttgccattc ttcctatatc     2460

ctggaatata tcttgcatcc tgagtttata ataataaata atattctacc ttggaaa        2517


<210>  14
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Arg Pro Asp Arg Ala Glu Ala Pro Gly Pro Pro Ala Met Ala Ala 
1               5                   10                  15      


Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser Thr Ser Ser 
            20                  25                  30          


Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg Leu Ser Leu 
        35                  40                  45              


Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr Ala Leu Ala 
    50                  55                  60                  


Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu Glu Thr Gln 
65                  70                  75                  80  


Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly Arg Pro Gly 
                85                  90                  95      


Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu Gly Arg Asp 
            100                 105                 110         


Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Gly His Met Pro Glu Arg 
        115                 120                 125             


Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp Ile Gln Phe Val Gln 
    130                 135                 140                 


Glu Met Ile Arg Gln Leu Glu Gln Thr Asn Tyr Arg Leu Lys Leu Cys 
145                 150                 155                 160 


Val Ser Asp Arg Asp Val Leu Pro Gly Thr Cys Val Trp Ser Ile Ala 
                165                 170                 175     


Ser Ala Ala Gly Trp Trp Trp Leu Ser Leu Met Ile Thr Cys Arg Ala 
            180                 185                 190         


Arg Asn Val Thr Ser Arg Pro Asn Leu His Ser Ala Ser Leu Gln Val 
        195                 200                 205             


Pro Ile Arg Ser Asp 
    210             


<210>  15
<211>  3057
<212>  DNA
<213>  Homo sapiens

<400>  15
cactttcgag agtgccgtct atttgccaca cacttccctg atgaaatgtc tggatttgga       60

ctaaagaaaa aaggaaaggc tagcagtcat ccaacagaat catgagacag actttgcctt      120

gtatctactt ttgggggggc cttttgccct ttgggatgct gtgtgcatcc tccaccacca      180

agtgcactgt tagccatgaa gttgctgact gcagccacct gaagttgact caggtacccg      240

atgatctacc cacaaacata acagtgttga accttaccca taatcaactc agaagattac      300

cagccgccaa cttcacaagg tatagccagc taactagctt ggatgtagga tttaacacca      360

tctcaaaact ggagccagaa ttgtgccaga aacttcccat gttaaaagtt ttgaacctcc      420

agcacaatga gctatctcaa ctttctgata aaacctttgc cttctgcacg aatttgactg      480

aactccatct catgtccaac tcaatccaga aaattaaaaa taatcccttt gtcaagcaga      540

agaatttaat cacattagat ctgtctcata atggcttgtc atctacaaaa ttaggaactc      600

aggttcagct ggaaaatctc caagagcttc tattatcaaa caataaaatt caagcgctaa      660

aaagtgaaga actggatatc tttgccaatt catctttaaa aaaattagag ttgtcatcga      720

atcaaattaa agagttttct ccagggtgtt ttcacgcaat tggaagatta tttggcctct      780

ttctgaacaa tgtccagctg ggtcccagcc ttacagagaa gctatgtttg gaattagcaa      840

acacaagcat tcggaatctg tctctgagta acagccagct gtccaccacc agcaatacaa      900

ctttcttggg actaaagtgg acaaatctca ctatgctcga tctttcctac aacaacttaa      960

atgtggttgg taacgattcc tttgcttggc ttccacaact agaatatttc ttcctagagt     1020

ataataatat acagcatttg ttttctcact ctttgcacgg gcttttcaat gtgaggtacc     1080

tgaatttgaa acggtctttt actaaacaaa gtatttccct tgcctcactc cccaagattg     1140

atgatttttc ttttcagtgg ctaaaatgtt tggagcacct taacatggaa gataatgata     1200

ttccaggcat aaaaagcaat atgttcacag gattgataaa cctgaaatac ttaagtctat     1260

ccaactcctt tacaagtttg cgaactttga caaatgaaac atttgtatca cttgctcatt     1320

ctcccttaca catactcaac ctaaccaaga ataaaatctc aaaaatagag agtgatgctt     1380

tctcttggtt gggccaccta gaagtacttg acctgggcct taatgaaatt gggcaagaac     1440

tcacaggcca ggaatggaga ggtctagaaa atattttcga aatctatctt tcctacaaca     1500

agtacctgca gctgactagg aactcctttg ccttggtccc aagccttcaa cgactgatgc     1560

tccgaagggt ggcccttaaa aatgtggata gctctccttc accattccag cctcttcgta     1620

acttgaccat tctggatcta agcaacaaca acatagccaa cataaatgat gacatgttgg     1680

agggtcttga gaaactagaa attctcgatt tgcagcataa caacttagca cggctctgga     1740

aacacgcaaa ccctggtggt cccatttatt tcctaaaggg tctgtctcac ctccacatcc     1800

ttaacttgga gtccaacggc tttgacgaga tcccagttga ggtcttcaag gatttatttg     1860

aactaaagat catcgattta ggattgaata atttaaacac acttccagca tctgtcttta     1920

ataatcaggt gtctctaaag tcattgaacc ttcagaagaa tctcataaca tccgttgaga     1980

agaaggtttt cgggccagct ttcaggaacc tgactgagtt agatatgcgc tttaatccct     2040

ttgattgcac gtgtgaaagt attgcctggt ttgttaattg gattaacgag acccatacca     2100

acatccctga gctgtcaagc cactaccttt gcaacactcc acctcactat catgggttcc     2160

cagtgagact ttttgataca tcatcttgca aagacagtgc cccctttgaa ctctttttca     2220

tgatcaatac cagtatcctg ttgattttta tctttattgt acttctcatc cactttgagg     2280

gctggaggat atctttttat tggaatgttt cagtacatcg agttcttggt ttcaaagaaa     2340

tagacagaca gacagaacag tttgaatatg cagcatatat aattcatgcc tataaagata     2400

aggattgggt ctgggaacat ttctcttcaa tggaaaagga agaccaatct ctcaaatttt     2460

gtctggaaga aagggacttt gaggcgggtg tttttgaact agaagcaatt gttaacagca     2520

tcaaaagaag cagaaaaatt atttttgtta taacacacca tctattaaaa gacccattat     2580

gcaaaagatt caaggtacat catgcagttc aacaagctat tgaacaaaat ctggattcca     2640

ttatattggt tttccttgag gagattccag attataaact gaaccatgca ctctgtttgc     2700

gaagaggaat gtttaaatct cactgcatct tgaactggcc agttcagaaa gaacggatag     2760

gtgcctttcg tcataaattg caagtagcac ttggatccaa aaactctgta cattaaattt     2820

atttaaatat tcaattagca aaggagaaac tttctcaatt taaaaagttc tatggcaaat     2880

ttaagttttc cataaaggtg ttataatttg tttattcata tttgtaaatg attatattct     2940

atcacaatta catctcttct aggaaaatgt gtctccttat ttcaggccta tttttgacaa     3000

ttgacttaat tttacccaaa ataaaacata taagcacgta aaaaaaaaaa aaaaaaa        3057


<210>  16
<211>  904
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Ser Thr Thr Lys Cys Thr Val Ser His 
            20                  25                  30          


Glu Val Ala Asp Cys Ser His Leu Lys Leu Thr Gln Val Pro Asp Asp 
        35                  40                  45              


Leu Pro Thr Asn Ile Thr Val Leu Asn Leu Thr His Asn Gln Leu Arg 
    50                  55                  60                  


Arg Leu Pro Ala Ala Asn Phe Thr Arg Tyr Ser Gln Leu Thr Ser Leu 
65                  70                  75                  80  


Asp Val Gly Phe Asn Thr Ile Ser Lys Leu Glu Pro Glu Leu Cys Gln 
                85                  90                  95      


Lys Leu Pro Met Leu Lys Val Leu Asn Leu Gln His Asn Glu Leu Ser 
            100                 105                 110         


Gln Leu Ser Asp Lys Thr Phe Ala Phe Cys Thr Asn Leu Thr Glu Leu 
        115                 120                 125             


His Leu Met Ser Asn Ser Ile Gln Lys Ile Lys Asn Asn Pro Phe Val 
    130                 135                 140                 


Lys Gln Lys Asn Leu Ile Thr Leu Asp Leu Ser His Asn Gly Leu Ser 
145                 150                 155                 160 


Ser Thr Lys Leu Gly Thr Gln Val Gln Leu Glu Asn Leu Gln Glu Leu 
                165                 170                 175     


Leu Leu Ser Asn Asn Lys Ile Gln Ala Leu Lys Ser Glu Glu Leu Asp 
            180                 185                 190         


Ile Phe Ala Asn Ser Ser Leu Lys Lys Leu Glu Leu Ser Ser Asn Gln 
        195                 200                 205             


Ile Lys Glu Phe Ser Pro Gly Cys Phe His Ala Ile Gly Arg Leu Phe 
    210                 215                 220                 


Gly Leu Phe Leu Asn Asn Val Gln Leu Gly Pro Ser Leu Thr Glu Lys 
225                 230                 235                 240 


Leu Cys Leu Glu Leu Ala Asn Thr Ser Ile Arg Asn Leu Ser Leu Ser 
                245                 250                 255     


Asn Ser Gln Leu Ser Thr Thr Ser Asn Thr Thr Phe Leu Gly Leu Lys 
            260                 265                 270         


Trp Thr Asn Leu Thr Met Leu Asp Leu Ser Tyr Asn Asn Leu Asn Val 
        275                 280                 285             


Val Gly Asn Asp Ser Phe Ala Trp Leu Pro Gln Leu Glu Tyr Phe Phe 
    290                 295                 300                 


Leu Glu Tyr Asn Asn Ile Gln His Leu Phe Ser His Ser Leu His Gly 
305                 310                 315                 320 


Leu Phe Asn Val Arg Tyr Leu Asn Leu Lys Arg Ser Phe Thr Lys Gln 
                325                 330                 335     


Ser Ile Ser Leu Ala Ser Leu Pro Lys Ile Asp Asp Phe Ser Phe Gln 
            340                 345                 350         


Trp Leu Lys Cys Leu Glu His Leu Asn Met Glu Asp Asn Asp Ile Pro 
        355                 360                 365             


Gly Ile Lys Ser Asn Met Phe Thr Gly Leu Ile Asn Leu Lys Tyr Leu 
    370                 375                 380                 


Ser Leu Ser Asn Ser Phe Thr Ser Leu Arg Thr Leu Thr Asn Glu Thr 
385                 390                 395                 400 


Phe Val Ser Leu Ala His Ser Pro Leu His Ile Leu Asn Leu Thr Lys 
                405                 410                 415     


Asn Lys Ile Ser Lys Ile Glu Ser Asp Ala Phe Ser Trp Leu Gly His 
            420                 425                 430         


Leu Glu Val Leu Asp Leu Gly Leu Asn Glu Ile Gly Gln Glu Leu Thr 
        435                 440                 445             


Gly Gln Glu Trp Arg Gly Leu Glu Asn Ile Phe Glu Ile Tyr Leu Ser 
    450                 455                 460                 


Tyr Asn Lys Tyr Leu Gln Leu Thr Arg Asn Ser Phe Ala Leu Val Pro 
465                 470                 475                 480 


Ser Leu Gln Arg Leu Met Leu Arg Arg Val Ala Leu Lys Asn Val Asp 
                485                 490                 495     


Ser Ser Pro Ser Pro Phe Gln Pro Leu Arg Asn Leu Thr Ile Leu Asp 
            500                 505                 510         


Leu Ser Asn Asn Asn Ile Ala Asn Ile Asn Asp Asp Met Leu Glu Gly 
        515                 520                 525             


Leu Glu Lys Leu Glu Ile Leu Asp Leu Gln His Asn Asn Leu Ala Arg 
    530                 535                 540                 


Leu Trp Lys His Ala Asn Pro Gly Gly Pro Ile Tyr Phe Leu Lys Gly 
545                 550                 555                 560 


Leu Ser His Leu His Ile Leu Asn Leu Glu Ser Asn Gly Phe Asp Glu 
                565                 570                 575     


Ile Pro Val Glu Val Phe Lys Asp Leu Phe Glu Leu Lys Ile Ile Asp 
            580                 585                 590         


Leu Gly Leu Asn Asn Leu Asn Thr Leu Pro Ala Ser Val Phe Asn Asn 
        595                 600                 605             


Gln Val Ser Leu Lys Ser Leu Asn Leu Gln Lys Asn Leu Ile Thr Ser 
    610                 615                 620                 


Val Glu Lys Lys Val Phe Gly Pro Ala Phe Arg Asn Leu Thr Glu Leu 
625                 630                 635                 640 


Asp Met Arg Phe Asn Pro Phe Asp Cys Thr Cys Glu Ser Ile Ala Trp 
                645                 650                 655     


Phe Val Asn Trp Ile Asn Glu Thr His Thr Asn Ile Pro Glu Leu Ser 
            660                 665                 670         


Ser His Tyr Leu Cys Asn Thr Pro Pro His Tyr His Gly Phe Pro Val 
        675                 680                 685             


Arg Leu Phe Asp Thr Ser Ser Cys Lys Asp Ser Ala Pro Phe Glu Leu 
    690                 695                 700                 


Phe Phe Met Ile Asn Thr Ser Ile Leu Leu Ile Phe Ile Phe Ile Val 
705                 710                 715                 720 


Leu Leu Ile His Phe Glu Gly Trp Arg Ile Ser Phe Tyr Trp Asn Val 
                725                 730                 735     


Ser Val His Arg Val Leu Gly Phe Lys Glu Ile Asp Arg Gln Thr Glu 
            740                 745                 750         


Gln Phe Glu Tyr Ala Ala Tyr Ile Ile His Ala Tyr Lys Asp Lys Asp 
        755                 760                 765             


Trp Val Trp Glu His Phe Ser Ser Met Glu Lys Glu Asp Gln Ser Leu 
    770                 775                 780                 


Lys Phe Cys Leu Glu Glu Arg Asp Phe Glu Ala Gly Val Phe Glu Leu 
785                 790                 795                 800 


Glu Ala Ile Val Asn Ser Ile Lys Arg Ser Arg Lys Ile Ile Phe Val 
                805                 810                 815     


Ile Thr His His Leu Leu Lys Asp Pro Leu Cys Lys Arg Phe Lys Val 
            820                 825                 830         


His His Ala Val Gln Gln Ala Ile Glu Gln Asn Leu Asp Ser Ile Ile 
        835                 840                 845             


Leu Val Phe Leu Glu Glu Ile Pro Asp Tyr Lys Leu Asn His Ala Leu 
    850                 855                 860                 


Cys Leu Arg Arg Gly Met Phe Lys Ser His Cys Ile Leu Asn Trp Pro 
865                 870                 875                 880 


Val Gln Lys Glu Arg Ile Gly Ala Phe Arg His Lys Leu Gln Val Ala 
                885                 890                 895     


Leu Gly Ser Lys Asn Ser Val His 
            900                 


<210>  17
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'-3'

<400>  17
gacgacgtgc tgctggag                                                     18


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'-3'

<400>  18
gaaggcatcg aaacgctcag g                                                 21


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'-3'

<400>  19
agagtgccgt ctatttgcca                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'-3'

<400>  20
gtggtggagg atgcacacag                                                   20


<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1-G93A forward

<400>  21
catcagccct aatccatctg a                                                 21


<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1-G93A reverse

<400>  22
cgcgactaac aatcatgaaa g                                                 21


<210>  23
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2 forward

<400>  23
ctaggccaca gaattgaaag atct                                              24


<210>  24
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2 reverse

<400>  24
gtaggtggaa attctagcat catcc                                             25


<210>  25
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPRTex3_For

<400>  25
gtaatgatca gtcaacgggg gac                                               23


<210>  26
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPRTex7 Rev

<400>  26
ccagcaagct tgcaacctta acca                                              24


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TLR4

<400>  27
accaggaagc ttgaatccct                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TLR4 Rev

<400>  28
tccagccact gaagttctga                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MyD88_For

<400>  29
agagctgctg gccttgttag                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MyD88_Rev

<400>  30
tcatctcctg cacaaactcg                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ciclofilina B For

<400>  31
cttccccgat gagaacttca                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ciclofilina B_Rev

<400>  32
tcttggtgct ctccaccttc                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TLR2_For

<400>  33
ctcggagttc tcccagtgtt                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TLR2_Rev

<400>  34
caagacccac accatccaca                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TLR3_For

<400>  35
agagtgccgt ctatttgcca                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TLR3_Rev

<400>  36
gtggtggagg atgcacacag                                                   20


