                         SEQUENCE LISTING

<110>  Cornell Research Foundation
       Dana-Farber Cancer Institute, Inc.
 
<120>  MALT1 INHIBITORS AND USES THEREOF

<130>  C1134.70005WO00

<140>  Not Yet Assigned 
<141>  Concurrently Herewith

<150>  US 62/256,672
<151>  2015-11-17

<150>  US 62/211,629
<151>  2015-08-28

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  824
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Leu Leu Gly Asp Pro Leu Gln Ala Leu Pro Pro Ser Ala Ala 
1               5                   10                  15      


Pro Thr Gly Pro Leu Leu Ala Pro Pro Ala Gly Ala Thr Leu Asn Arg 
            20                  25                  30          


Leu Arg Glu Pro Leu Leu Arg Arg Leu Ser Glu Leu Leu Asp Gln Ala 
        35                  40                  45              


Pro Glu Gly Arg Gly Trp Arg Arg Leu Ala Glu Leu Ala Gly Ser Arg 
    50                  55                  60                  


Gly Arg Leu Arg Leu Ser Cys Leu Asp Leu Glu Gln Cys Ser Leu Lys 
65                  70                  75                  80  


Val Leu Glu Pro Glu Gly Ser Pro Ser Leu Cys Leu Leu Lys Leu Met 
                85                  90                  95      


Gly Glu Lys Gly Cys Thr Val Thr Glu Leu Ser Asp Phe Leu Gln Ala 
            100                 105                 110         


Met Glu His Thr Glu Val Leu Gln Leu Leu Ser Pro Pro Gly Ile Lys 
        115                 120                 125             


Ile Thr Val Asn Pro Glu Ser Lys Ala Val Leu Ala Gly Gln Phe Val 
    130                 135                 140                 


Lys Leu Cys Cys Arg Ala Thr Gly His Pro Phe Val Gln Tyr Gln Trp 
145                 150                 155                 160 


Phe Lys Met Asn Lys Glu Ile Pro Asn Gly Asn Thr Ser Glu Leu Ile 
                165                 170                 175     


Phe Asn Ala Val His Val Lys Asp Ala Gly Phe Tyr Val Cys Arg Val 
            180                 185                 190         


Asn Asn Asn Phe Thr Phe Glu Phe Ser Gln Trp Ser Gln Leu Asp Val 
        195                 200                 205             


Cys Asp Ile Pro Glu Ser Phe Gln Arg Ser Val Asp Gly Val Ser Glu 
    210                 215                 220                 


Ser Lys Leu Gln Ile Cys Val Glu Pro Thr Ser Gln Lys Leu Met Pro 
225                 230                 235                 240 


Gly Ser Thr Leu Val Leu Gln Cys Val Ala Val Gly Ser Pro Ile Pro 
                245                 250                 255     


His Tyr Gln Trp Phe Lys Asn Glu Leu Pro Leu Thr His Glu Thr Lys 
            260                 265                 270         


Lys Leu Tyr Met Val Pro Tyr Val Asp Leu Glu His Gln Gly Thr Tyr 
        275                 280                 285             


Trp Cys His Val Tyr Asn Asp Arg Asp Ser Gln Asp Ser Lys Lys Val 
    290                 295                 300                 


Glu Ile Ile Ile Gly Arg Thr Asp Glu Ala Val Glu Cys Thr Glu Asp 
305                 310                 315                 320 


Glu Leu Asn Asn Leu Gly His Pro Asp Asn Lys Glu Gln Thr Thr Asp 
                325                 330                 335     


Gln Pro Leu Ala Lys Asp Lys Val Ala Leu Leu Ile Gly Asn Met Asn 
            340                 345                 350         


Tyr Arg Glu His Pro Lys Leu Lys Ala Pro Leu Val Asp Val Tyr Glu 
        355                 360                 365             


Leu Thr Asn Leu Leu Arg Gln Leu Asp Phe Lys Val Val Ser Leu Leu 
    370                 375                 380                 


Asp Leu Thr Glu Tyr Glu Met Arg Asn Ala Val Asp Glu Phe Leu Leu 
385                 390                 395                 400 


Leu Leu Asp Lys Gly Val Tyr Gly Leu Leu Tyr Tyr Ala Gly His Gly 
                405                 410                 415     


Tyr Glu Asn Phe Gly Asn Ser Phe Met Val Pro Val Asp Ala Pro Asn 
            420                 425                 430         


Pro Tyr Arg Ser Glu Asn Cys Leu Cys Val Gln Asn Ile Leu Lys Leu 
        435                 440                 445             


Met Gln Glu Lys Glu Thr Gly Leu Asn Val Phe Leu Leu Asp Met Cys 
    450                 455                 460                 


Arg Lys Arg Asn Asp Tyr Asp Asp Thr Ile Pro Ile Leu Asp Ala Leu 
465                 470                 475                 480 


Lys Val Thr Ala Asn Ile Val Phe Gly Tyr Ala Thr Cys Gln Gly Ala 
                485                 490                 495     


Glu Ala Phe Glu Ile Gln His Ser Gly Leu Ala Asn Gly Ile Phe Met 
            500                 505                 510         


Lys Phe Leu Lys Asp Arg Leu Leu Glu Asp Lys Lys Ile Thr Val Leu 
        515                 520                 525             


Leu Asp Glu Val Ala Glu Asp Met Gly Lys Cys His Leu Thr Lys Gly 
    530                 535                 540                 


Lys Gln Ala Leu Glu Ile Arg Ser Ser Leu Ser Glu Lys Arg Ala Leu 
545                 550                 555                 560 


Thr Asp Pro Ile Gln Gly Thr Glu Tyr Ser Ala Glu Ser Leu Val Arg 
                565                 570                 575     


Asn Leu Gln Trp Ala Lys Ala His Glu Leu Pro Glu Ser Met Cys Leu 
            580                 585                 590         


Lys Phe Asp Cys Gly Val Gln Ile Gln Leu Gly Phe Ala Ala Glu Phe 
        595                 600                 605             


Ser Asn Val Met Ile Ile Tyr Thr Ser Ile Val Tyr Lys Pro Pro Glu 
    610                 615                 620                 


Ile Ile Met Cys Asp Ala Tyr Val Thr Asp Phe Pro Leu Asp Leu Asp 
625                 630                 635                 640 


Ile Asp Pro Lys Asp Ala Asn Lys Gly Thr Pro Glu Glu Thr Gly Ser 
                645                 650                 655     


Tyr Leu Val Ser Lys Asp Leu Pro Lys His Cys Leu Tyr Thr Arg Leu 
            660                 665                 670         


Ser Ser Leu Gln Lys Leu Lys Glu His Leu Val Phe Thr Val Cys Leu 
        675                 680                 685             


Ser Tyr Gln Tyr Ser Gly Leu Glu Asp Thr Val Glu Asp Lys Gln Glu 
    690                 695                 700                 


Val Asn Val Gly Lys Pro Leu Ile Ala Lys Leu Asp Met His Arg Gly 
705                 710                 715                 720 


Leu Gly Arg Lys Thr Cys Phe Gln Thr Cys Leu Met Ser Asn Gly Pro 
                725                 730                 735     


Tyr Gln Ser Ser Ala Ala Thr Ser Gly Gly Ala Gly His Tyr His Ser 
            740                 745                 750         


Leu Gln Asp Pro Phe His Gly Val Tyr His Ser His Pro Gly Asn Pro 
        755                 760                 765             


Ser Asn Val Thr Pro Ala Asp Ser Cys His Cys Ser Arg Thr Pro Asp 
    770                 775                 780                 


Ala Phe Ile Ser Ser Phe Ala His His Ala Ser Cys His Phe Ser Arg 
785                 790                 795                 800 


Ser Asn Val Pro Val Glu Thr Thr Asp Glu Ile Pro Phe Ser Phe Ser 
                805                 810                 815     


Asp Arg Leu Arg Ile Ser Glu Lys 
            820                 


<210>  2
<211>  813
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Leu Leu Gly Asp Pro Leu Gln Ala Leu Pro Pro Ser Ala Ala 
1               5                   10                  15      


Pro Thr Gly Pro Leu Leu Ala Pro Pro Ala Gly Ala Thr Leu Asn Arg 
            20                  25                  30          


Leu Arg Glu Pro Leu Leu Arg Arg Leu Ser Glu Leu Leu Asp Gln Ala 
        35                  40                  45              


Pro Glu Gly Arg Gly Trp Arg Arg Leu Ala Glu Leu Ala Gly Ser Arg 
    50                  55                  60                  


Gly Arg Leu Arg Leu Ser Cys Leu Asp Leu Glu Gln Cys Ser Leu Lys 
65                  70                  75                  80  


Val Leu Glu Pro Glu Gly Ser Pro Ser Leu Cys Leu Leu Lys Leu Met 
                85                  90                  95      


Gly Glu Lys Gly Cys Thr Val Thr Glu Leu Ser Asp Phe Leu Gln Ala 
            100                 105                 110         


Met Glu His Thr Glu Val Leu Gln Leu Leu Ser Pro Pro Gly Ile Lys 
        115                 120                 125             


Ile Thr Val Asn Pro Glu Ser Lys Ala Val Leu Ala Gly Gln Phe Val 
    130                 135                 140                 


Lys Leu Cys Cys Arg Ala Thr Gly His Pro Phe Val Gln Tyr Gln Trp 
145                 150                 155                 160 


Phe Lys Met Asn Lys Glu Ile Pro Asn Gly Asn Thr Ser Glu Leu Ile 
                165                 170                 175     


Phe Asn Ala Val His Val Lys Asp Ala Gly Phe Tyr Val Cys Arg Val 
            180                 185                 190         


Asn Asn Asn Phe Thr Phe Glu Phe Ser Gln Trp Ser Gln Leu Asp Val 
        195                 200                 205             


Cys Asp Ile Pro Glu Ser Phe Gln Arg Ser Val Asp Gly Val Ser Glu 
    210                 215                 220                 


Ser Lys Leu Gln Ile Cys Val Glu Pro Thr Ser Gln Lys Leu Met Pro 
225                 230                 235                 240 


Gly Ser Thr Leu Val Leu Gln Cys Val Ala Val Gly Ser Pro Ile Pro 
                245                 250                 255     


His Tyr Gln Trp Phe Lys Asn Glu Leu Pro Leu Thr His Glu Thr Lys 
            260                 265                 270         


Lys Leu Tyr Met Val Pro Tyr Val Asp Leu Glu His Gln Gly Thr Tyr 
        275                 280                 285             


Trp Cys His Val Tyr Asn Asp Arg Asp Ser Gln Asp Ser Lys Lys Val 
    290                 295                 300                 


Glu Ile Ile Ile Asp Glu Leu Asn Asn Leu Gly His Pro Asp Asn Lys 
305                 310                 315                 320 


Glu Gln Thr Thr Asp Gln Pro Leu Ala Lys Asp Lys Val Ala Leu Leu 
                325                 330                 335     


Ile Gly Asn Met Asn Tyr Arg Glu His Pro Lys Leu Lys Ala Pro Leu 
            340                 345                 350         


Val Asp Val Tyr Glu Leu Thr Asn Leu Leu Arg Gln Leu Asp Phe Lys 
        355                 360                 365             


Val Val Ser Leu Leu Asp Leu Thr Glu Tyr Glu Met Arg Asn Ala Val 
    370                 375                 380                 


Asp Glu Phe Leu Leu Leu Leu Asp Lys Gly Val Tyr Gly Leu Leu Tyr 
385                 390                 395                 400 


Tyr Ala Gly His Gly Tyr Glu Asn Phe Gly Asn Ser Phe Met Val Pro 
                405                 410                 415     


Val Asp Ala Pro Asn Pro Tyr Arg Ser Glu Asn Cys Leu Cys Val Gln 
            420                 425                 430         


Asn Ile Leu Lys Leu Met Gln Glu Lys Glu Thr Gly Leu Asn Val Phe 
        435                 440                 445             


Leu Leu Asp Met Cys Arg Lys Arg Asn Asp Tyr Asp Asp Thr Ile Pro 
    450                 455                 460                 


Ile Leu Asp Ala Leu Lys Val Thr Ala Asn Ile Val Phe Gly Tyr Ala 
465                 470                 475                 480 


Thr Cys Gln Gly Ala Glu Ala Phe Glu Ile Gln His Ser Gly Leu Ala 
                485                 490                 495     


Asn Gly Ile Phe Met Lys Phe Leu Lys Asp Arg Leu Leu Glu Asp Lys 
            500                 505                 510         


Lys Ile Thr Val Leu Leu Asp Glu Val Ala Glu Asp Met Gly Lys Cys 
        515                 520                 525             


His Leu Thr Lys Gly Lys Gln Ala Leu Glu Ile Arg Ser Ser Leu Ser 
    530                 535                 540                 


Glu Lys Arg Ala Leu Thr Asp Pro Ile Gln Gly Thr Glu Tyr Ser Ala 
545                 550                 555                 560 


Glu Ser Leu Val Arg Asn Leu Gln Trp Ala Lys Ala His Glu Leu Pro 
                565                 570                 575     


Glu Ser Met Cys Leu Lys Phe Asp Cys Gly Val Gln Ile Gln Leu Gly 
            580                 585                 590         


Phe Ala Ala Glu Phe Ser Asn Val Met Ile Ile Tyr Thr Ser Ile Val 
        595                 600                 605             


Tyr Lys Pro Pro Glu Ile Ile Met Cys Asp Ala Tyr Val Thr Asp Phe 
    610                 615                 620                 


Pro Leu Asp Leu Asp Ile Asp Pro Lys Asp Ala Asn Lys Gly Thr Pro 
625                 630                 635                 640 


Glu Glu Thr Gly Ser Tyr Leu Val Ser Lys Asp Leu Pro Lys His Cys 
                645                 650                 655     


Leu Tyr Thr Arg Leu Ser Ser Leu Gln Lys Leu Lys Glu His Leu Val 
            660                 665                 670         


Phe Thr Val Cys Leu Ser Tyr Gln Tyr Ser Gly Leu Glu Asp Thr Val 
        675                 680                 685             


Glu Asp Lys Gln Glu Val Asn Val Gly Lys Pro Leu Ile Ala Lys Leu 
    690                 695                 700                 


Asp Met His Arg Gly Leu Gly Arg Lys Thr Cys Phe Gln Thr Cys Leu 
705                 710                 715                 720 


Met Ser Asn Gly Pro Tyr Gln Ser Ser Ala Ala Thr Ser Gly Gly Ala 
                725                 730                 735     


Gly His Tyr His Ser Leu Gln Asp Pro Phe His Gly Val Tyr His Ser 
            740                 745                 750         


His Pro Gly Asn Pro Ser Asn Val Thr Pro Ala Asp Ser Cys His Cys 
        755                 760                 765             


Ser Arg Thr Pro Asp Ala Phe Ile Ser Ser Phe Ala His His Ala Ser 
    770                 775                 780                 


Cys His Phe Ser Arg Ser Asn Val Pro Val Glu Thr Thr Asp Glu Ile 
785                 790                 795                 800 


Pro Phe Ser Phe Ser Asp Arg Leu Arg Ile Ser Glu Lys 
                805                 810             


<210>  3
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  3

Met Ala Gly Pro His Pro Val Ile Val Ile Thr Gly Pro His Glu Glu 
1               5                   10                  15      


