
                                SEQUENCE LISTING

<110> GENENTECH, INC.
      F. HOFFMANN-LA ROCHE AG
      ZHAI, Qianting
      CARTER, Paul J.
      
      

<120> ANTI-HYPUSINE ANTIBODIES AND USES
  THEREOF

<130> 146392034440

<140> Not yet Assigned    
<141> Concurrently Herewith            

<150> US 62/211,642       
<151> 2015-08-28  

<160> 72

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 1
Gln Ser Ser Glu Thr Val Tyr Arg Gly Asp Trp Leu Ser
 1               5                  10              


<210> 2
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 2
Arg Ser Arg Gln Arg Val Tyr Leu Gly Asp Trp Leu Ser
 1               5                  10              


<210> 3
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 3
Gln Ala Ser Glu Asp Ile Lys Arg Tyr Leu Ala
 1               5                  10      


<210> 4
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 4
Asp Ala Ser Tyr Leu Ala Ser
 1               5          


<210> 5
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 5
Asp Ala Ser Phe Arg Gly Asp
 1               5          


<210> 6
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 6
Ala Ala Ser Lys Leu Ala Ser
 1               5          


<210> 7
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 7
Leu Gly Gly Tyr Tyr Asp Asp Ala Asp Asp Thr
 1               5                  10      


<210> 8
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 8
Gln Gln Gly Tyr Thr Ser Ser Asn Val Asn Asn Ala
 1               5                  10          


<210> 9
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 9
Asp Tyr Ala Met Ile
 1               5  


<210> 10
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 10
Thr Tyr Thr Ile Asn
 1               5  


<210> 11
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 11
Thr Tyr Thr Met Asn
 1               5  


<210> 12
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 12
His Cys Thr Met Asn
 1               5  


<210> 13
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 13
Ile Ile Tyr Gly Gly Ser Asn Lys Leu Ala Tyr Ala Lys Trp Ala
 1               5                  10                  15  


<210> 14
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 14
Ile Ile Tyr Gly Val Ile Asn Asp Leu Ala Tyr Ala Lys Trp Ala
 1               5                  10                  15  


<210> 15
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 15
Asp Ile Trp Ser Asp Gly Asn Thr Tyr Tyr Ala Asn Trp Ala
 1               5                  10                  


<210> 16
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 16
Asp Ile Tyr Thr Asp Gly Asn Thr Tyr Tyr Ala Asn Trp Ala
 1               5                  10                  


<210> 17
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 17
Gly Tyr Gly Ser Met Asp Gly Tyr Asp Arg Leu Asn Leu
 1               5                  10              


<210> 18
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 18
Asp Ser Trp Asp Thr Ser Ile Tyr Tyr Gly Leu Asp Leu
 1               5                  10              


<210> 19
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 19
Asp Ser Trp Asp Ala Ser Ser Tyr Tyr Gly Leu Asp Leu
 1               5                  10              


<210> 20
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 20
Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly
 1               5                  10                  15      
Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Glu Thr Val Tyr Arg Gly
            20                  25                  30          
Asp Trp Leu Ser Trp Phe Gln Lys Lys Pro Gly Gln Pro Pro Lys Leu
        35                  40                  45              
Leu Ile Tyr Asp Ala Ser Tyr Leu Ala Ser Gly Val Ser Ser Arg Phe
    50                  55                  60                  
Ser Gly Ser Gly Ser Gly Thr His Phe Thr Leu Thr Ile Ser Gly Val
65                  70                  75                  80  
Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Tyr Asp
                85                  90                  95      
Asp Ala Asp Asp Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys
            100                 105                 110     


<210> 21
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 21
Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly
 1               5                  10                  15      
Gly Thr Val Thr Ile Ser Cys Arg Ser Arg Gln Arg Val Tyr Leu Gly
            20                  25                  30          
Asp Trp Leu Ser Trp Phe Gln Lys Lys Pro Gly Gln Pro Pro Lys Leu
        35                  40                  45              
Leu Ile Tyr Asp Ala Ser Phe Arg Gly Asp Gly Val Ser Ser Arg Phe
    50                  55                  60                  
Ser Gly Ser Gly Ser Gly Thr His Phe Thr Leu Thr Ile Ser Gly Val
65                  70                  75                  80  
Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Tyr Asp
                85                  90                  95      
Asp Ala Asp Asp Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys
            100                 105                 110     


<210> 22
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 22
Ala Ile Lys Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly
 1               5                  10                  15      
Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Asp Ile Lys Arg Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Lys Leu Ala Ser Gly Val Ser Ser Arg Phe Thr Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Gln Cys
65                  70                  75                  80  
Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Ser Thr Asn
                85                  90                  95      
Val Asn Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys
            100                 105                 110 


<210> 23
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 23
Ala Ile Lys Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly
 1               5                  10                  15      
Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Asp Ile Lys Arg Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Lys Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Gln Cys
65                  70                  75                  80  
Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Ser Ser Asn
                85                  90                  95      
Val Asn Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys
            100                 105                 110 


<210> 24
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 24
Gln Glu Gln Leu Lys Glu Ser Gly Gly Arg Leu Val Ala Pro Gly Thr
 1               5                  10                  15      
Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Asp Ile Ser Asp Tyr
            20                  25                  30          
Ala Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ile Ile Tyr Gly Gly Ser Asn Lys Leu Ala Tyr Ala Lys Trp Ala
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys
65                  70                  75                  80  
Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg
                85                  90                  95      
Gly Tyr Gly Ser Met Asp Gly Tyr Asp Arg Leu Asn Leu Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 25
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 25
Gln Glu Gln Leu Lys Glu Ser Gly Gly Arg Leu Val Ala Pro Gly Thr
 1               5                  10                  15      
Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Asp Ile Ser Asp Tyr
            20                  25                  30          
Ala Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ile Ile Tyr Gly Val Ile Asn Asp Leu Ala Tyr Ala Lys Trp Ala
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys
65                  70                  75                  80  
Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg
                85                  90                  95      
Gly Tyr Gly Ser Met Asp Gly Tyr Asp Arg Leu Asn Leu Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 26
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 26
Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro
 1               5                  10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Ala Phe Ser Leu Ser Thr Tyr Thr
            20                  25                  30          
Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly
        35                  40                  45              
Asp Ile Trp Ser Asp Gly Asn Thr Tyr Tyr Ala Asn Trp Ala Lys Gly
    50                  55                  60                  
Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr
65                  70                  75                  80  
Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Ser
                85                  90                  95      
Trp Asp Thr Ser Ile Tyr Tyr Gly Leu Asp Leu Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 27
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 27
Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro
 1               5                  10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Thr Tyr Thr
            20                  25                  30          
Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly
        35                  40                  45              
Asp Ile Tyr Thr Asp Gly Asn Thr Tyr Tyr Ala Asn Trp Ala Lys Gly
    50                  55                  60                  
Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr
65                  70                  75                  80  
Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Ser
                85                  90                  95      
Trp Asp Ala Ser Ser Tyr Tyr Gly Leu Asp Leu Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 28
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 28
Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro
 1               5                  10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Ala Cys Ser Leu Tyr His Cys Thr
            20                  25                  30          
Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly
        35                  40                  45              
Asp Ile Tyr Thr Asp Gly Asn Thr Tyr Tyr Ala Asn Trp Ala Lys Gly
    50                  55                  60                  
Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr
65                  70                  75                  80  
Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Ser
                85                  90                  95      
Trp Asp Ala Ser Ser Tyr Tyr Gly Leu Asp Leu Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 29
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 29
Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly
 1               5                  10                  15      
Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Glu Thr Val Tyr Arg Gly
            20                  25                  30          
Asp Trp Leu Ser Trp Phe Gln Lys Lys Pro Gly Gln Pro Pro Lys Leu
        35                  40                  45              
Leu Ile Tyr Asp Ala Ser Tyr Leu Ala Ser Gly Val Ser Ser Arg Phe
    50                  55                  60                  
Ser Gly Ser Gly Ser Gly Thr His Phe Thr Leu Thr Ile Ser Gly Val
65                  70                  75                  80  
Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Tyr Asp
                85                  90                  95      
Asp Ala Asp Asp Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys Gly
            100                 105                 110         
Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro Pro Ala Ala Asp Gln
        115                 120                 125             
Val Ala Thr Gly Thr Val Thr Ile Val Cys Val Ala Asn Lys Tyr Phe
    130                 135                 140                 
Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly Thr Thr Gln Thr Thr
145                 150                 155                 160 
Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala Asp Cys Thr Tyr
                165                 170                 175     
Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln Tyr Asn Ser His
            180                 185                 190         
Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr Ser Val Val Gln
        195                 200                 205             
Ser Phe Asn Arg Gly Asp Cys
    210                 215 


<210> 30
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 30
Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly
 1               5                  10                  15      
Gly Thr Val Thr Ile Ser Cys Arg Ser Arg Gln Arg Val Tyr Leu Gly
            20                  25                  30          
Asp Trp Leu Ser Trp Phe Gln Lys Lys Pro Gly Gln Pro Pro Lys Leu
        35                  40                  45              
Leu Ile Tyr Asp Ala Ser Phe Arg Gly Asp Gly Val Ser Ser Arg Phe
    50                  55                  60                  
Ser Gly Ser Gly Ser Gly Thr His Phe Thr Leu Thr Ile Ser Gly Val
65                  70                  75                  80  
Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Tyr Asp
                85                  90                  95      
Asp Ala Asp Asp Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys Gly
            100                 105                 110         
Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro Pro Ala Ala Asp Gln
        115                 120                 125             
Val Ala Thr Gly Thr Val Thr Ile Val Cys Val Ala Asn Lys Tyr Phe
    130                 135                 140                 
Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly Thr Thr Gln Thr Thr
145                 150                 155                 160 
Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala Asp Cys Thr Tyr
                165                 170                 175     
Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln Tyr Asn Ser His
            180                 185                 190         
Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr Ser Val Val Gln
        195                 200                 205             
Ser Phe Asn Arg Gly Asp Cys
    210                 215 


<210> 31
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 31
Ala Ile Lys Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly
 1               5                  10                  15      
Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Asp Ile Lys Arg Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Lys Leu Ala Ser Gly Val Ser Ser Arg Phe Thr Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Gln Cys
65                  70                  75                  80  
Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Ser Thr Asn
                85                  90                  95      
Val Asn Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Gly Asp
            100                 105                 110         
Pro Val Ala Pro Thr Val Leu Ile Phe Pro Pro Ala Ala Asp Gln Val
        115                 120                 125             
Ala Thr Gly Thr Val Thr Ile Val Cys Val Ala Asn Lys Tyr Phe Pro
    130                 135                 140                 
Asp Val Thr Val Thr Trp Glu Val Asp Gly Thr Thr Gln Thr Thr Gly
145                 150                 155                 160 
Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala Asp Cys Thr Tyr Asn
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln Tyr Asn Ser His Lys
            180                 185                 190         
Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr Ser Val Val Gln Ser
        195                 200                 205             
Phe Asn Arg Gly Asp Cys
    210                 


<210> 32
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 32
Ala Ile Lys Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly
 1               5                  10                  15      
Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Asp Ile Lys Arg Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Lys Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Gln Cys
65                  70                  75                  80  
Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Ser Ser Asn
                85                  90                  95      
Val Asn Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Gly Asp
            100                 105                 110         
Pro Val Ala Pro Thr Val Leu Ile Phe Pro Pro Ala Ala Asp Gln Val
        115                 120                 125             
Ala Thr Gly Thr Val Thr Ile Val Cys Val Ala Asn Lys Tyr Phe Pro
    130                 135                 140                 
Asp Val Thr Val Thr Trp Glu Val Asp Gly Thr Thr Gln Thr Thr Gly
145                 150                 155                 160 
Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala Asp Cys Thr Tyr Asn
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln Tyr Asn Ser His Lys
            180                 185                 190         
Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr Ser Val Val Gln Ser
        195                 200                 205             
Phe Asn Arg Gly Asp Cys
    210                 


<210> 33
<211> 224
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 33
Gln Glu Gln Leu Lys Glu Ser Gly Gly Arg Leu Val Ala Pro Gly Thr
 1               5                  10                  15      
Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Asp Ile Ser Asp Tyr
            20                  25                  30          
Ala Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ile Ile Tyr Gly Gly Ser Asn Lys Leu Ala Tyr Ala Lys Trp Ala
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys
65                  70                  75                  80  
Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg
                85                  90                  95      
Gly Tyr Gly Ser Met Asp Gly Tyr Asp Arg Leu Asn Leu Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Gly Gln Pro Lys Gly Pro Ser Val
        115                 120                 125             
Phe Pro Leu Ala Pro Cys Cys Gly Asp Thr Pro Ser Ser Thr Val Thr
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Gly Tyr Leu Pro Glu Pro Val Thr Val Thr
145                 150                 155                 160 
Trp Asn Ser Gly Thr Leu Thr Asn Gly Val Arg Thr Phe Pro Ser Val
                165                 170                 175     
Arg Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Ser Val Thr
            180                 185                 190         
Ser Ser Ser Gln Pro Val Thr Cys Asn Val Ala His Pro Ala Thr Asn
        195                 200                 205             
Thr Lys Val Asp Lys Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr
    210                 215                 220                 


<210> 34
<211> 224
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 34
Gln Glu Gln Leu Lys Glu Ser Gly Gly Arg Leu Val Ala Pro Gly Thr
 1               5                  10                  15      
Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Asp Ile Ser Asp Tyr
            20                  25                  30          
Ala Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ile Ile Tyr Gly Val Ile Asn Asp Leu Ala Tyr Ala Lys Trp Ala
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys
65                  70                  75                  80  
Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg
                85                  90                  95      
Gly Tyr Gly Ser Met Asp Gly Tyr Asp Arg Leu Asn Leu Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Gly Gln Pro Lys Gly Pro Ser Val
        115                 120                 125             
Phe Pro Leu Ala Pro Cys Cys Gly Asp Thr Pro Ser Ser Thr Val Thr
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Gly Tyr Leu Pro Glu Pro Val Thr Val Thr
145                 150                 155                 160 
Trp Asn Ser Gly Thr Leu Thr Asn Gly Val Arg Thr Phe Pro Ser Val
                165                 170                 175     
Arg Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Ser Val Thr
            180                 185                 190         
Ser Ser Ser Gln Pro Val Thr Cys Asn Val Ala His Pro Ala Thr Asn
        195                 200                 205             
Thr Lys Val Asp Lys Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr
    210                 215                 220                 


<210> 35
<211> 222
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 35
Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro
 1               5                  10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Ala Phe Ser Leu Ser Thr Tyr Thr
            20                  25                  30          
Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly
        35                  40                  45              
Asp Ile Trp Ser Asp Gly Asn Thr Tyr Tyr Ala Asn Trp Ala Lys Gly
    50                  55                  60                  
Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr
65                  70                  75                  80  
Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Ser
                85                  90                  95      
Trp Asp Thr Ser Ile Tyr Tyr Gly Leu Asp Leu Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser Gly Gln Pro Lys Gly Pro Ser Val Phe Pro
        115                 120                 125             
Leu Ala Pro Cys Cys Gly Asp Thr Pro Ser Ser Thr Val Thr Leu Gly
    130                 135                 140                 
Cys Leu Val Lys Gly Tyr Leu Pro Glu Pro Val Thr Val Thr Trp Asn
145                 150                 155                 160 
Ser Gly Thr Leu Thr Asn Gly Val Arg Thr Phe Pro Ser Val Arg Gln
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Ser Val Thr Ser Ser
            180                 185                 190         
Ser Gln Pro Val Thr Cys Asn Val Ala His Pro Ala Thr Asn Thr Lys
        195                 200                 205             
Val Asp Lys Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr
    210                 215                 220         


<210> 36
<211> 222
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 36
Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro
 1               5                  10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Thr Tyr Thr
            20                  25                  30          
Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly
        35                  40                  45              
Asp Ile Tyr Thr Asp Gly Asn Thr Tyr Tyr Ala Asn Trp Ala Lys Gly
    50                  55                  60                  
Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr
65                  70                  75                  80  
Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Ser
                85                  90                  95      
Trp Asp Ala Ser Ser Tyr Tyr Gly Leu Asp Leu Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser Gly Gln Pro Lys Gly Pro Ser Val Phe Pro
        115                 120                 125             
Leu Ala Pro Cys Cys Gly Asp Thr Pro Ser Ser Thr Val Thr Leu Gly
    130                 135                 140                 
Cys Leu Val Lys Gly Tyr Leu Pro Glu Pro Val Thr Val Thr Trp Asn
145                 150                 155                 160 
Ser Gly Thr Leu Thr Asn Gly Val Arg Thr Phe Pro Ser Val Arg Gln
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Ser Val Thr Ser Ser
            180                 185                 190         
Ser Gln Pro Val Thr Cys Asn Val Ala His Pro Ala Thr Asn Thr Lys
        195                 200                 205             
Val Asp Lys Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr
    210                 215                 220         


<210> 37
<211> 222
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 37
Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro
 1               5                  10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Ala Cys Ser Leu Tyr His Cys Thr
            20                  25                  30          
Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly
        35                  40                  45              
Asp Ile Tyr Thr Asp Gly Asn Thr Tyr Tyr Ala Asn Trp Ala Lys Gly
    50                  55                  60                  
Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr
65                  70                  75                  80  
Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Ser
                85                  90                  95      
Trp Asp Ala Ser Ser Tyr Tyr Gly Leu Asp Leu Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser Gly Gln Pro Lys Gly Pro Ser Val Phe Pro
        115                 120                 125             
Leu Ala Pro Cys Cys Gly Asp Thr Pro Ser Ser Thr Val Thr Leu Gly
    130                 135                 140                 
Cys Leu Val Lys Gly Tyr Leu Pro Glu Pro Val Thr Val Thr Trp Asn
145                 150                 155                 160 
Ser Gly Thr Leu Thr Asn Gly Val Arg Thr Phe Pro Ser Val Arg Gln
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Ser Val Thr Ser Ser
            180                 185                 190         
Ser Gln Pro Val Thr Cys Asn Val Ala His Pro Ala Thr Asn Thr Lys
        195                 200                 205             
Val Asp Lys Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr
    210                 215                 220         


<210> 38
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 38
Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly
 1               5                  10                  15      
Gly Thr Val Thr Ile Ser Cys
            20              


<210> 39
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 39
Ala Ile Lys Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly
 1               5                  10                  15      
Gly Thr Val Thr Ile Asn Cys
            20              


<210> 40
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 40
Trp Phe Gln Lys Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr
 1               5                  10                  15  


<210> 41
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 41
Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr
 1               5                  10                  15  


<210> 42
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 42
Gly Val Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr His Phe Thr
 1               5                  10                  15      
Leu Thr Ile Ser Gly Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys
            20                  25                  30          


<210> 43
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 43
Gly Val Ser Ser Arg Phe Thr Gly Ser Gly Ser Gly Thr Glu Tyr Thr
 1               5                  10                  15      
Leu Thr Ile Ser Gly Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys
            20                  25                  30          


<210> 44
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 44
Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Tyr Thr
 1               5                  10                  15      
Leu Thr Ile Ser Gly Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys
            20                  25                  30          


<210> 45
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 45
Phe Gly Gly Gly Thr Glu Val Val Val Lys
 1               5                  10  


<210> 46
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 46
Gln Glu Gln Leu Lys Glu Ser Gly Gly Arg Leu Val Ala Pro Gly Thr
 1               5                  10                  15      
Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Asp Ile Ser
            20                  25                  30  


<210> 47
<211> 29
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 47
Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro
 1               5                  10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Ala Phe Ser Leu Ser
            20                  25                  


<210> 48
<211> 29
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 48
Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro
 1               5                  10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser
            20                  25                  


<210> 49
<211> 29
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 49
Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro
 1               5                  10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Ala Cys Ser Leu Tyr
            20                  25                  


<210> 50
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 50
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly
 1               5                  10                  


<210> 51
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 51
Lys Gly Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys
 1               5                  10                  15      
Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg
            20                  25                  30          


<210> 52
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 52
Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys
 1               5                  10                  15      
Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg
            20                  25                  30          


<210> 53
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 53
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
 1               5                  10      


<210> 54
<211> 1
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Hypusine modified with (PEG)6-Cysteine 
at carboxy terminus

<400> 54
Xaa
 1  


<210> 55
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Hypusine

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = Glycine modified with (PEG)6-Cysteine 
at carboxy terminus

<400> 55
Gly Ser Gly Xaa Gly Ser Xaa
 1               5          


<210> 56
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Glycine modified with biotin-(PEG)6
at amino terminus

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Hypusine

<400> 56
Xaa Ser Gly Xaa Gly Ser Gly
 1               5          


<210> 57
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Glycine modified with biotin-(PEG)6
at amino terminus

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Deoxyhypusine

<400> 57
Xaa Ser Gly Xaa Gly Ser Gly
 1               5          


<210> 58
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Glycine modified with biotin-(PEG)6
at amino terminus

<400> 58
Xaa Ser Gly Lys Gly Ser Gly
 1               5          


<210> 59
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Serine modified with biotin-(PEG)6
at amino terminus

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = Hypusine

<400> 59
Xaa Thr Ser Lys Thr Gly Xaa His Gly His Ala Lys
 1               5                  10          


<210> 60
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Serine modified with biotin-(PEG)6
at amino terminus

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = Deoxyhypusine

<400> 60
Xaa Thr Ser Lys Thr Gly Xaa His Gly His Ala Lys
 1               5                  10          


<210> 61
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Serine modified with biotin-(PEG)6
at amino terminus

<400> 61
Xaa Thr Ser Lys Thr Gly Lys His Gly His Ala Lys
 1               5                  10          


<210> 62
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Biotinylated glycine

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = Hypusine

<400> 62
Xaa Gly Asp Glu Glu Ala Leu Xaa Gln Leu Ala Glu Trp Val Ser
 1               5                  10                  15  


<210> 63
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Biotinylated glycine

<400> 63
Xaa Gly Asp Glu Glu Ala Leu Lys Gln Leu Ala Glu Trp Val Ser
 1               5                  10                  15  


<210> 64
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Biotinylated glycine

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = Hypusine

<220> 
<221> VARIANT        
<222> 12
<223> Xaa = Hypusine

<220> 
<221> VARIANT        
<222> 17
<223> Xaa = Hypusine

<400> 64
Xaa Gly Ala Ala Ala Ala Xaa Ala Ala Ala Ala Xaa Ala Ala Ala Ala
 1               5                  10                  15      
Xaa Ala
        


<210> 65
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Biotinylated glycine

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = Hypusine

<220> 
<221> VARIANT        
<222> 17
<223> Xaa = Hypusine

<400> 65
Xaa Gly Ala Ala Ala Ala Xaa Ala Ala Ala Ala Lys Ala Ala Ala Ala
 1               5                  10                  15      
Xaa Ala
        


<210> 66
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = Hypusine

<220> 
<221> VARIANT        
<222> 18
<223> Xaa = Biotinylated glycine

<400> 66
Gly Trp Xaa Pro Met Ser Arg Ser Ser Gly Arg Val Tyr Tyr Phe Asn
 1               5                  10                  15      
Gly Xaa
        


<210> 67
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 18
<223> Xaa = Biotinylated glycine

<400> 67
Gly Trp Lys Pro Met Ser Arg Ser Ser Gly Arg Val Tyr Tyr Phe Asn
 1               5                  10                  15      
Gly Xaa
        


<210> 68
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Biotinylated glycine

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = Hypusine

<400> 68
Xaa Gly Leu Leu Glu Leu Asp Xaa Trp Ala Ser Leu Trp
 1               5                  10              


<210> 69
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Biotinylated glycine

<400> 69
Xaa Gly Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp
 1               5                  10              


<210> 70
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Hypusine

<400> 70
Gly Ser Gly Xaa Gly Ser Gly
 1               5          


<210> 71
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Deoxyhypusine

<400> 71
Gly Ser Gly Xaa Gly Ser Gly
 1               5          


<210> 72
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 72
Gln Gln Gly Tyr Thr Ser Thr Asn Val Asn Asn Ala
 1               5                  10          

