                         SEQUENCE LISTING

<110>  The Board of Regents of the University of Oklahoma
       Ballard, Jimmy
       Larabee, Jason
 
<120>  PEPTIDE INHIBITORS OF CLOSTRIDIUM DIFFICILE TcdB TOXIN

<130>  820233.02343

<150>  US 62/214,082
<151>  2015-09-03

<160>  68    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(11)

<400>  1

Asn Val Phe Lys Gly Asn Thr Ile Ser Asp Lys 
1               5                   10      


<210>  2
<211>  20
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(20)

<400>  2

Asp Phe Ile Leu Met Ser Thr Asp Glu Glu Asn Lys Val Ser Gln Val 
1               5                   10                  15      


Lys Ile Arg Phe 
            20  


<210>  3
<211>  18
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(18)

<400>  3

Met Ser Thr Asp Glu Glu Asn Lys Val Ser Gln Val Lys Ile Arg Phe 
1               5                   10                  15      


Thr Asn 
        


<210>  4
<211>  19
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(19)

<400>  4

Ser Gln Val Lys Ile Arg Phe Thr Asn Val Phe Lys Gly Asn Thr Ile 
1               5                   10                  15      


Ser Asp Lys 
            


<210>  5
<211>  17
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(17)

<400>  5

Arg Phe Thr Asn Val Phe Lys Gly Asn Thr Ile Ser Asp Lys Ile Ser 
1               5                   10                  15      


Phe 
    


<210>  6
<211>  19
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(19)

<400>  6

Asn Val Phe Lys Gly Asn Thr Ile Ser Asp Lys Ile Ser Phe Asn Ser 
1               5                   10                  15      


Phe Asp Lys 
            


<210>  7
<211>  18
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(18)

<400>  7

Phe Asn Phe Ser Asp Lys Gln Asp Val Ser Ile Asn Lys Val Ile Ser 
1               5                   10                  15      


Thr Phe 
        


<210>  8
<211>  19
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(19)

<400>  8

Lys Gln Asp Val Ser Ile Asn Lys Val Ile Ser Thr Phe Thr Pro Ser 
1               5                   10                  15      


Tyr Tyr Val 
            


<210>  9
<211>  17
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(17)

<400>  9

Glu Gly Leu Leu Asn Tyr Asp Leu Gly Leu Ile Ser Leu Tyr Asn Glu 
1               5                   10                  15      


Lys 
    


<210>  10
<211>  21
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(21)

<400>  10

Lys Pro Pro Ile Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp 
1               5                   10                  15      


Asp Lys Tyr Tyr Phe 
            20      


<210>  11
<211>  20
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(20)

<400>  11

Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp Lys Tyr Tyr 
1               5                   10                  15      


Phe Asn Pro Asp 
            20  


<210>  12
<211>  19
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(19)

<400>  12

Asp Asp Lys Tyr Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val 
1               5                   10                  15      


Gly Glu Thr 
            


<210>  13
<211>  19
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(19)

<400>  13

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala Pro 
1               5                   10                  15      


Ala Asp Thr 
            


<210>  14
<211>  19
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(19)

<400>  14

Thr Gly Arg Ala Phe Lys Gly Leu Asn Gln Ile Gly Asp Asp Lys Phe 
1               5                   10                  15      


Tyr Phe Asn 
            


<210>  15
<211>  19
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(19)

<400>  15

Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe 
1               5                   10                  15      


Ser Asp Lys 
            


<210>  16
<211>  19
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  Mutant of SEQ ID NO:6

<400>  16

Asn Val Phe Lys Asp Lys Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe 
1               5                   10                  15      


Ser Asp Lys 
            


<210>  17
<211>  19
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  Mutant of SEQ ID NO:6

<400>  17

Asn Val Phe Lys Gly Asn Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe 
1               5                   10                  15      


Ser Asp Lys 
            


<210>  18
<211>  19
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  Mutant of SEQ ID NO:6

<400>  18

Asn Val Phe Lys Asp Asn Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe 
1               5                   10                  15      


Ser Asp Lys 
            


<210>  19
<211>  19
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  Mutant of SEQ ID NO:6

<400>  19

Asn Val Phe Lys Ser Asn Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe 
1               5                   10                  15      


Ser Asp Lys 
            


<210>  20
<211>  19
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  Mutant of SEQ ID NO:6

<400>  20

Asn Val Phe Lys Gly Lys Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe 
1               5                   10                  15      


Ser Asp Lys 
            


<210>  21
<211>  19
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  Mutant of SEQ ID NO:6

<400>  21

Asn Val Ala Lys Gly Asn Thr Ile Ser Asp Lys Ile Ser Ala Asn Ala 
1               5                   10                  15      


Ser Asp Lys 
            


<210>  22
<211>  19
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  Mutant of SEQ ID NO:6

<400>  22

Asn Val Trp Lys Gly Asn Thr Ile Ser Asp Lys Ile Ser Trp Asn Trp 
1               5                   10                  15      


Ser Asp Lys 
            


<210>  23
<211>  19
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  Mutant of SEQ ID NO:6

<400>  23

Asn Val Tyr Lys Gly Asn Thr Ile Ser Asp Lys Ile Ser Tyr Asn Tyr 
1               5                   10                  15      


Ser Asp Lys 
            


<210>  24
<211>  16
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(16)

<400>  24

Asn Val Phe Lys Gly Asn Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe 
1               5                   10                  15      


<210>  25
<211>  14
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(14)

<400>  25

Asn Val Phe Lys Gly Asn Thr Ile Ser Asp Lys Ile Ser Phe 
1               5                   10                  


<210>  26
<211>  11
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(11)

<400>  26

Asn Val Phe Lys Gly Asn Thr Ile Ser Asp Lys 
1               5                   10      


<210>  27
<211>  17
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(17)

<400>  27

Phe Lys Gly Asn Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp 
1               5                   10                  15      


Lys 
    


<210>  28
<211>  16
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(16)

<400>  28

Lys Gly Asn Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp Lys 
1               5                   10                  15      


<210>  29
<211>  12
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(12)

<400>  29

Phe Lys Gly Asn Thr Ile Ser Asp Lys Ile Ser Phe 
1               5                   10          


<210>  30
<211>  10
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(10)

<400>  30

Gly Asn Thr Ile Ser Asp Lys Ile Ser Phe 
1               5                   10  


<210>  31
<211>  19
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  Completely synthesized in the lab using random combinations of amino acids of SEQ ID NO:6.

<400>  31

Ser Ser Lys Asp Lys Ile Val Ser Phe Lys Asn Gly Phe Thr Phe Asp 
1               5                   10                  15      


Ile Asn Asn 
            


<210>  32
<211>  19
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  Completely synthesized in the lab using random combinations of amino acids of SEQ ID NO:6.

<400>  32

Ile Lys Lys Ser Asn Val Phe Asn Ser Phe Phe Asp Ser Ile Asn Gly 
1               5                   10                  15      


Lys Thr Asp 
            


<210>  33
<211>  19
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  Completely synthesized in the lab using random combinations of amino acids of SEQ ID NO:6.

<400>  33

Phe Gly Asn Lys Phe Thr Ser Val Asp Asn Ser Lys Ile Lys Phe Ile 
1               5                   10                  15      


Asp Ser Asn 
            


<210>  34
<211>  19
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  Completely synthesized in the lab using random combinations of amino acids of SEQ ID NO:6.

<400>  34

Ile Gly Val Phe Ser Asn Asp Lys Lys Asn Ile Asn Thr Ser Phe Asp 
1               5                   10                  15      


Phe Ser Lys 
            


<210>  35
<211>  19
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  Completely synthesized in the lab using random combinations of amino acids of SEQ ID NO:6.

<400>  35

Lys Phe Val Phe Asp Asp Ile Lys Asn Ser Ser Ile Ser Asn Lys Thr 
1               5                   10                  15      


Phe Asn Gly 
            


<210>  36
<211>  19
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  Completely synthesized in the lab using random combinations of amino acids of SEQ ID NO:6.

<400>  36

Gly Ser Ser Ser Ile Ile Asn Asp Asp Phe Lys Asn Val Thr Lys Asn 
1               5                   10                  15      


Lys Phe Phe 
            


<210>  37
<211>  19
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  Completely synthesized in the lab using random combinations of amino acids of SEQ ID NO:6.

<400>  37

Phe Lys Asp Asn Asn Ser Ile Ile Phe Asp Val Lys Gly Thr Asn Phe 
1               5                   10                  15      


Ser Ser Lys 
            


<210>  38
<211>  19
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  Completely synthesized in the lab using random combinations of amino acids of SEQ ID NO:6.

<400>  38

Asp Lys Phe Ser Asn Ser Asn Lys Asp Lys Ile Ser Phe Gly Asn Val 
1               5                   10                  15      


Thr Phe Ile 
            


<210>  39
<211>  19
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  Completely synthesized in the lab using random combinations of amino acids of SEQ ID NO:6.

<400>  39

Asn Phe Asn Ile Ser Val Ser Lys Asp Phe Phe Ser Gly Lys Thr Asn 
1               5                   10                  15      


Ile Asp Lys 
            


<210>  40
<211>  19
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  Completely synthesized in the lab using random combinations of amino acids of SEQ ID NO:6.

<400>  40

Ser Asn Lys Asn Phe Ser Gly Ile Val Phe Thr Asn Phe Asp Ile Asp 
1               5                   10                  15      


Lys Ser Lys 
            


<210>  41
<211>  18
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(18)

<400>  41

Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys Ile Arg Phe 
1               5                   10                  15      


Val Asn 
        


<210>  42
<211>  19
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(19)

<400>  42

Ser Gln Val Lys Ile Arg Phe Val Met Val Phe Lys Asp Lys Thr Leu 
1               5                   10                  15      


Ala Asn Lys 
            


<210>  43
<211>  17
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(17)

<400>  43

Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu Ser 
1               5                   10                  15      


Phe 
    


<210>  44
<211>  19
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(19)

<400>  44

Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe 
1               5                   10                  15      


Ser Asp Lys 
            


<210>  45
<211>  17
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(17)

<400>  45

Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile Leu Gln Lys Ile Arg Ile 
1               5                   10                  15      


Lys 
    


<210>  46
<211>  22
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(22)

<400>  46

Glu Glu Ser Asn Lys Lys Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile 
1               5                   10                  15      


Leu Ser Asn Thr Gln Ser 
            20          


<210>  47
<211>  20
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(20)

<400>  47

Ser Asn Lys Lys Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser 
1               5                   10                  15      


Asn Thr Gln Ser 
            20  


<210>  48
<211>  19
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(19)

<400>  48

Lys Gly Ile Leu Ser Asn Thr Gln Ser Phe Asn Lys Met Ser Ile Asp 
1               5                   10                  15      


Phe Lys Asp 
            


<210>  49
<211>  22
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(22)

<400>  49

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser 
1               5                   10                  15      


Leu Gly Tyr Ile Met Ser 
            20          


<210>  50
<211>  21
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(21)

<400>  50

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn 
1               5                   10                  15      


Glu Leu Asp Arg Asp 
            20      


<210>  51
<211>  20
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(20)

<400>  51

Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn Glu Leu Asp Arg Asp His 
1               5                   10                  15      


Leu Gly Phe Lys 
            20  


<210>  52
<211>  20
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(20)

<400>  52

Lys Phe Ser Asn Ser Glu Asn Glu Leu Asp Arg Asp His Leu Gly Phe 
1               5                   10                  15      


Lys Ile Ile Asp 
            20  


<210>  53
<211>  20
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(20)

<400>  53

Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys Thr Tyr Tyr Tyr 
1               5                   10                  15      


Asp Glu Asp Ser 
            20  


<210>  54
<211>  18
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(18)

<400>  54

Ile Ala Asn Ser Glu Glu Asp Asn Gln Pro Gln Val Lys Ile Arg Phe 
1               5                   10                  15      


Val Asn 
        


<210>  55
<211>  19
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(19)

<400>  55

Pro Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Ser Asp Thr Ala 
1               5                   10                  15      


Ala Asp Lys 
            


<210>  56
<211>  17
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(17)

<400>  56

Arg Phe Val Asn Val Phe Lys Ser Asp Thr Ala Ala Asp Lys Leu Ser 
1               5                   10                  15      


Phe 
    


<210>  57
<211>  19
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(19)

<400>  57

Asn Val Phe Lys Ser Asp Thr Ala Ala Asp Lys Leu Ser Phe Asn Phe 
1               5                   10                  15      


Ser Asp Lys 
            


<210>  58
<211>  18
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(18)

<400>  58

Phe Asn Phe Ser Asp Lys Gln Asp Val Ser Val Ser Lys Ile Ile Ser 
1               5                   10                  15      


Thr Phe 
        


<210>  59
<211>  19
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(19)

<400>  59

Lys Asp Phe Lys Trp Asp Ile Lys Gly Asn Asp Ile Ile Leu Val Arg 
1               5                   10                  15      


Lys Lys Ile 
            


<210>  60
<211>  19
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(19)

<400>  60

Ile Ile Leu Val Arg Lys Lys Ile Asn Gly Phe Asn Ser Thr Ile Leu 
1               5                   10                  15      


Leu Lys Asp 
            


<210>  61
<211>  19
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(19)

<400>  61

Lys Lys Ile Asn Gly Phe Asn Ser Thr Ile Leu Leu Lys Asp Thr Ile 
1               5                   10                  15      


Asp Asn Asn 
            


<210>  62
<211>  20
<212>  PRT
<213>  Clostridium difficile


<220>
<221>  PEPTIDE
<222>  (1)..(20)

<400>  62

Lys Asp Thr Ile Asp Asn Asn Ser Tyr Phe Asn Tyr Val Thr Leu Ile 
1               5                   10                  15      


Phe Asn Asp Lys 
            20  


<210>  63
<211>  13
<212>  PRT
<213>  Human immunodeficiency virus-1


<220>
<221>  PEPTIDE
<222>  (1)..(13)
<223>  TAT

<400>  63

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  64
<211>  21
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  PEPTIDE
<222>  (1)..(21)
<223>  Pep-1

<400>  64

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  65
<211>  21
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  PEPTIDE
<222>  (1)..(21)
<223>  Transportan

<400>  65

Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  66
<211>  16
<212>  PRT
<213>  Drosophila melanogaster


<220>
<221>  PEPTIDE
<222>  (1)..(16)
<223>  Penetratin

<400>  66

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  67
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Completely synthesized in the lab, mutant of SEQ ID NO:1.


<220>
<221>  Variant
<222>  (1)..(1)
<223>  Xaa can be gly, L-ala, L-arg,  L-asn, L-asp, L-cys, L-glu, L-gln, L-his, L-ile, L-leu, L-lys, L- met, L-phe,  L-pro,  L-ser,  L-thr,  L-trp, L-tyr, L-val, D-ala,  D-arg,  D-asn, D-asp, D-cys,  D-glu, D-gln, D-his, D-ile, D-leu, D-lys, D-met, D-phe, D-pro, D-ser, D-thr, D-trp, D-tyr, and D-val

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa can be gly, L-ala, L-arg,  L-asn, L-asp, L-cys, L-glu, L-gln, L-his, L-ile, L-leu, L-lys, L- met, L-phe,  L-pro,  L-ser,  L-thr,  L-trp, L-tyr, L-val, D-ala,  D-arg,  D-asn, D-asp, D-cys,  D-glu, D-gln, D-his, D-ile, D-leu, D-lys, D-met, D-phe, D-pro, D-ser, D-thr, D-trp, D-tyr, and D-val

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa can be gly, L-ala, L-arg,  L-asn, L-asp, L-cys, L-glu, L-gln, L-his, L-ile, L-leu, L-lys, L- met, L-phe,  L-pro,  L-ser,  L-thr,  L-trp, L-tyr, L-val, D-ala,  D-arg,  D-asn, D-asp, D-cys,  D-glu, D-gln, D-his, D-ile, D-leu, D-lys, D-met, D-phe, D-pro, D-ser, D-thr, D-trp, D-tyr, and D-val or L-phe, L-met, L-leu, L-ile, D-phe, D-met, D-leu and D-ile

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa can be gly, L-ala, L-arg,  L-asn, L-asp, L-cys, L-glu, L-gln, L-his, L-ile, L-leu, L-lys, L- met, L-phe,  L-pro,  L-ser,  L-thr,  L-trp, L-tyr, L-val, D-ala,  D-arg,  D-asn, D-asp, D-cys,  D-glu, D-gln, D-his, D-ile, D-leu, D-lys, D-met, D-phe, D-pro, D-ser, D-thr, D-trp, D-tyr, and D-val

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa can be gly, L-ala, L-ser, D-ala, and D-ser

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa can be L-asn, L-asp, L-gln, L-his, L-ser,  L-thr, D-asn, D-asp, D-gln, D-his, D-ser, and D-thr

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa can be gly, L-ala, L-arg,  L-asn, L-asp, L-cys, L-glu, L-gln, L-his, L-ile, L-leu, L-lys, L- met, L-phe,  L-pro,  L-ser,  L-thr,  L-trp, L-tyr, L-val, D-ala,  D-arg,  D-asn, D-asp, D-cys,  D-glu, D-gln, D-his, D-ile, D-leu, D-lys, D-met, D-phe, D-pro, D-ser, D-thr, D-trp, D-tyr, and D-val


<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa can be gly, L-ala, L-arg,  L-asn, L-asp, L-cys, L-glu, L-gln, L-his, L-ile, L-leu, L-lys, L- met, L-phe,  L-pro,  L-ser,  L-thr,  L-trp, L-tyr, L-val, D-ala,  D-arg,  D-asn, D-asp, D-cys,  D-glu, D-gln, D-his, D-ile, D-leu, D-lys, D-met, D-phe, D-pro, D-ser, D-thr, D-trp, D-tyr, and D-val


<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa can be gly, L-ala, L-arg,  L-asn, L-asp, L-cys, L-glu, L-gln, L-his, L-ile, L-leu, L-lys, L- met, L-phe,  L-pro,  L-ser,  L-thr,  L-trp, L-tyr, L-val, D-ala,  D-arg,  D-asn, D-asp, D-cys,  D-glu, D-gln, D-his, D-ile, D-leu, D-lys, D-met, D-phe, D-pro, D-ser, D-thr, D-trp, D-tyr, and D-val


<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa can be gly, L-ala, L-arg,  L-asn, L-asp, L-cys, L-glu, L-gln, L-his, L-ile, L-leu, L-lys, L- met, L-phe,  L-pro,  L-ser,  L-thr,  L-trp, L-tyr, L-val, D-ala,  D-arg,  D-asn, D-asp, D-cys,  D-glu, D-gln, D-his, D-ile, D-leu, D-lys, D-met, D-phe, D-pro, D-ser, D-thr, D-trp, D-tyr, and D-val


<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa can be gly, L-ala, L-arg,  L-asn, L-asp, L-cys, L-glu, L-gln, L-his, L-ile, L-leu, L-lys, L- met, L-phe,  L-pro,  L-ser,  L-thr,  L-trp, L-tyr, L-val, D-ala,  D-arg,  D-asn, D-asp, D-cys,  D-glu, D-gln, D-his, D-ile, D-leu, D-lys, D-met, D-phe, D-pro, D-ser, D-thr, D-trp, D-tyr, and D-val

<400>  67

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1               5                   10 


<210>  68
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Completely synthesized in the lab, mutant of SEQ ID NO:6.


<220>
<221>  variant
<222>  (1)..(1)
<223>  Xaa can be gly, L-ala, L-arg,  L-asn, L-asp, L-cys, L-glu, L-gln, L-his, L-ile, L-leu, L-lys, L- met, L-phe,  L-pro,  L-ser,  L-thr,  L-trp, L-tyr, L-val, D-ala,  D-arg,  D-asn, D-asp, D-cys,  D-glu, D-gln, D-his, D-ile, D-leu, D-lys, D-met, D-phe, D-pro, D-ser, D-thr, D-trp, D-tyr, and D-val

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa can be gly, L-ala, L-arg,  L-asn, L-asp, L-cys, L-glu, L-gln, L-his, L-ile, L-leu, L-lys, L- met, L-phe,  L-pro,  L-ser,  L-thr,  L-trp, L-tyr, L-val, D-ala,  D-arg,  D-asn, D-asp, D-cys,  D-glu, D-gln, D-his, D-ile, D-leu, D-lys, D-met, D-phe, D-pro, D-ser, D-thr, D-trp, D-tyr, and D-val

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa can be gly, L-ala, L-arg,  L-asn, L-asp, L-cys, L-glu, L-gln, L-his, L-ile, L-leu, L-lys, L- met, L-phe,  L-pro,  L-ser,  L-thr,  L-trp, L-tyr, L-val, D-ala,  D-arg,  D-asn, D-asp, D-cys,  D-glu, D-gln, D-his, D-ile, D-leu, D-lys, D-met, D-phe, D-pro, D-ser, D-thr, D-trp, D-tyr, and D-val or L-phe, L-met, L-leu, L-ile, D-phe, D-met, d-leu, and D-ile

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa can be gly, L-ala, L-arg,  L-asn, L-asp, L-cys, L-glu, L-gln, L-his, L-ile, L-leu, L-lys, L- met, L-phe,  L-pro,  L-ser,  L-thr,  L-trp, L-tyr, L-val, D-ala,  D-arg,  D-asn, D-asp, D-cys,  D-glu, D-gln, D-his, D-ile, D-leu, D-lys, D-met, D-phe, D-pro, D-ser, D-thr, D-trp, D-tyr, and D-val

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa can be gly, L-ala, L-ser, D-ala, and D-ser or L-gly, L-asn, D-gly, D-asn

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa can be L-asn, L-asp, L-gln, L-his, L-ser,  L-thr, D-asn, D-asp, D-gln, D-his, D-ser, and D-thr or L-gly, L-asn, D-gly, D-asn

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa can be gly, L-ala, L-arg,  L-asn, L-asp, L-cys, L-glu, L-gln, L-his, L-ile, L-leu, L-lys, L- met, L-phe,  L-pro,  L-ser,  L-thr,  L-trp, L-tyr, L-val, D-ala,  D-arg,  D-asn, D-asp, D-cys,  D-glu, D-gln, D-his, D-ile, D-leu, D-lys, D-met, D-phe, D-pro, D-ser, D-thr, D-trp, D-tyr, and D-val

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa can be gly, L-ala, L-arg,  L-asn, L-asp, L-cys, L-glu, L-gln, L-his, L-ile, L-leu, L-lys, L- met, L-phe,  L-pro,  L-ser,  L-thr,  L-trp, L-tyr, L-val, D-ala,  D-arg,  D-asn, D-asp, D-cys,  D-glu, D-gln, D-his, D-ile, D-leu, D-lys, D-met, D-phe, D-pro, D-ser, D-thr, D-trp, D-tyr, and D-val

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa can be gly, L-ala, L-arg,  L-asn, L-asp, L-cys, L-glu, L-gln, L-his, L-ile, L-leu, L-lys, L- met, L-phe,  L-pro,  L-ser,  L-thr,  L-trp, L-tyr, L-val, D-ala,  D-arg,  D-asn, D-asp, D-cys,  D-glu, D-gln, D-his, D-ile, D-leu, D-lys, D-met, D-phe, D-pro, D-ser, D-thr, D-trp, D-tyr, and D-val

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa can be gly, L-ala, L-arg,  L-asn, L-asp, L-cys, L-glu, L-gln, L-his, L-ile, L-leu, L-lys, L- met, L-phe,  L-pro,  L-ser,  L-thr,  L-trp, L-tyr, L-val, D-ala,  D-arg,  D-asn, D-asp, D-cys,  D-glu, D-gln, D-his, D-ile, D-leu, D-lys, D-met, D-phe, D-pro, D-ser, D-thr, D-trp, D-tyr, and D-val

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa can be gly, L-ala, L-arg,  L-asn, L-asp, L-cys, L-glu, L-gln, L-his, L-ile, L-leu, L-lys, L- met, L-phe,  L-pro,  L-ser,  L-thr,  L-trp, L-tyr, L-val, D-ala,  D-arg,  D-asn, D-asp, D-cys,  D-glu, D-gln, D-his, D-ile, D-leu, D-lys, D-met, D-phe, D-pro, D-ser, D-thr, D-trp, D-tyr, and D-val

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa can be gly, L-ala, L-arg,  L-asn, L-asp, L-cys, L-glu, L-gln, L-his, L-ile, L-leu, L-lys, L- met, L-phe,  L-pro,  L-ser,  L-thr,  L-trp, L-tyr, L-val, D-ala,  D-arg,  D-asn, D-asp, D-cys,  D-glu, D-gln, D-his, D-ile, D-leu, D-lys, D-met, D-phe, D-pro, D-ser, D-thr, D-trp, D-tyr, and D-val

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  Xaa can be gly, L-ala, L-arg,  L-asn, L-asp, L-cys, L-glu, L-gln, L-his, L-ile, L-leu, L-lys, L- met, L-phe,  L-pro,  L-ser,  L-thr,  L-trp, L-tyr, L-val, D-ala,  D-arg,  D-asn, D-asp, D-cys,  D-glu, D-gln, D-his, D-ile, D-leu, D-lys, D-met, D-phe, D-pro, D-ser, D-thr, D-trp, D-tyr, and D-val

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Xaa can be gly, L-ala, L-arg,  L-asn, L-asp, L-cys, L-glu, L-gln, L-his, L-ile, L-leu, L-lys, L- met, L-phe,  L-pro,  L-ser,  L-thr,  L-trp, L-tyr, L-val, D-ala,  D-arg,  D-asn, D-asp, D-cys,  D-glu, D-gln, D-his, D-ile, D-leu, D-lys, D-met, D-phe, D-pro, D-ser, D-thr, D-trp, D-tyr, and D-val

<220>
<221>  VARIANT
<222>  (15)..(15)
<223>  Xaa can be gly, L-ala, L-arg,  L-asn, L-asp, L-cys, L-glu, L-gln, L-his, L-ile, L-leu, L-lys, L- met, L-phe,  L-pro,  L-ser,  L-thr,  L-trp, L-tyr, L-val, D-ala,  D-arg,  D-asn, D-asp, D-cys,  D-glu, D-gln, D-his, D-ile, D-leu, D-lys, D-met, D-phe, D-pro, D-ser, D-thr, D-trp, D-tyr, and D-val

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  Xaa can be gly, L-ala, L-arg,  L-asn, L-asp, L-cys, L-glu, L-gln, L-his, L-ile, L-leu, L-lys, L- met, L-phe,  L-pro,  L-ser,  L-thr,  L-trp, L-tyr, L-val, D-ala,  D-arg,  D-asn, D-asp, D-cys,  D-glu, D-gln, D-his, D-ile, D-leu, D-lys, D-met, D-phe, D-pro, D-ser, D-thr, D-trp, D-tyr, and D-val

<220>
<221>  VARIANT
<222>  (17)..(17)
<223>  Xaa can be gly, L-ala, L-arg,  L-asn, L-asp, L-cys, L-glu, L-gln, L-his, L-ile, L-leu, L-lys, L- met, L-phe,  L-pro,  L-ser,  L-thr,  L-trp, L-tyr, L-val, D-ala,  D-arg,  D-asn, D-asp, D-cys,  D-glu, D-gln, D-his, D-ile, D-leu, D-lys, D-met, D-phe, D-pro, D-ser, D-thr, D-trp, D-tyr, and D-val

<220>
<221>  VARIANT
<222>  (18)..(18)
<223>  Xaa can be gly, L-ala, L-arg,  L-asn, L-asp, L-cys, L-glu, L-gln, L-his, L-ile, L-leu, L-lys, L- met, L-phe,  L-pro,  L-ser,  L-thr,  L-trp, L-tyr, L-val, D-ala,  D-arg,  D-asn, D-asp, D-cys,  D-glu, D-gln, D-his, D-ile, D-leu, D-lys, D-met, D-phe, D-pro, D-ser, D-thr, D-trp, D-tyr, and D-val

<220>
<221>  VARIANT
<222>  (19)..(19)
<223>  Xaa can be gly, L-ala, L-arg,  L-asn, L-asp, L-cys, L-glu, L-gln, L-his, L-ile, L-leu, L-lys, L- met, L-phe,  L-pro,  L-ser,  L-thr,  L-trp, L-tyr, L-val, D-ala,  D-arg,  D-asn, D-asp, D-cys,  D-glu, D-gln, D-his, D-ile, D-leu, D-lys, D-met, D-phe, D-pro, D-ser, D-thr, D-trp, D-tyr, and D-val


<400>  68

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa 
            


