                         SEQUENCE LISTING

<110>  Theripion Inc.
 
<120>  ApoA-1 Fusion Polypeptides and Related Compositions and Methods

<130>  TRP-0110PC

<150>  US 62/215,256
<151>  2015-09-08

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  1602
<212>  DNA
<213>  Artificial

<220>
<223>  hWTAPO1-(g4s)4-mthIgG DNA

<400>  1
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc tctccggagg aggtggctca      840

ggtggtggag gatctggagg aggtgggagt ggtggaggtg gttctaccgg tctcgagccc      900

aaatcttctg acaaaactca cacatctcca ccgtccccag cacctgaact cctgggagga      960

tcgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     1020

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg     1080

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     1140

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1200

gagtacaagt gcaaggtctc caacaaagcc ctcccagcct ccatcgagaa aaccatctcc     1260

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1320

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1380

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1440

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1500

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1560

cagaagagcc tctctctctc tccgggtaaa tgataatcta ga                        1602


<210>  2
<211>  525
<212>  PRT
<213>  Artificial

<220>
<223>  hWTAPO1-(g4s)4-mthIgG


<220>
<221>  SIGNAL
<222>  (1)..(18)

<400>  2

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 
    290                 295                 300                 


Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu 
305                 310                 315                 320 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                325                 330                 335     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            340                 345                 350         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        355                 360                 365             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    370                 375                 380                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
385                 390                 395                 400 


Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys 
                405                 410                 415     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            420                 425                 430         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        435                 440                 445             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    450                 455                 460                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
465                 470                 475                 480 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                485                 490                 495     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            500                 505                 510         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        515                 520                 525 


<210>  3
<211>  2052
<212>  DNA
<213>  Artificial

<220>
<223>  hWTAPO1-(g4s)4-mthIgG-hRNase1 DNA

<400>  3
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc tctccggagg aggtggctca      840

ggtggtggag gatctggagg aggtgggagt ggtggaggtg gttctaccgg tctcgagccc      900

aaatcttctg acaaaactca cacatctcca ccgtccccag cacctgaact cctgggagga      960

tcgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     1020

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg     1080

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     1140

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1200

gagtacaagt gcaaggtctc caacaaagcc ctcccagcct ccatcgagaa aaccatctcc     1260

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1320

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1380

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1440

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1500

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1560

cagaagagcc tctctctctc tccgggtaaa gtcgacggag ctagcagccc cgtgaacgtg     1620

agcagcccca gcgtgcagga tatcccttcc ctgggcaagg aatcccgggc caagaaattc     1680

cagcggcagc atatggactc agacagttcc cccagcagca gctccaccta ctgtaaccaa     1740

atgatgaggc gccggaatat gacacagggg cggtgcaaac cagtgaacac ctttgtgcac     1800

gagcccctgg tagatgtcca gaatgtctgt ttccaggaaa aggtcacctg caagaacggg     1860

cagggcaact gctacaagag caactccagc atgcacatca cagactgccg cctgacaaac     1920

ggctccaggt accccaactg tgcataccgg accagcccga aggagagaca catcattgtg     1980

gcctgtgaag ggagcccata tgtgccagtc cactttgatg cttctgtgga ggactctacc     2040

taataatcta ga                                                         2052


<210>  4
<211>  675
<212>  PRT
<213>  Artificial

<220>
<223>  hWTAPO1-(g4s)4-mthIgG-hRNase1

<400>  4

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 
    290                 295                 300                 


Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu 
305                 310                 315                 320 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                325                 330                 335     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            340                 345                 350         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        355                 360                 365             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    370                 375                 380                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
385                 390                 395                 400 


Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys 
                405                 410                 415     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            420                 425                 430         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        435                 440                 445             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    450                 455                 460                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
465                 470                 475                 480 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                485                 490                 495     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            500                 505                 510         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly 
        515                 520                 525             


Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Pro 
    530                 535                 540                 


Ser Leu Gly Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His Met 
545                 550                 555                 560 


Asp Ser Asp Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln Met 
                565                 570                 575     


Met Arg Arg Arg Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn Thr 
            580                 585                 590         


Phe Val His Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln Glu 
        595                 600                 605             


Lys Val Thr Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn Ser 
    610                 615                 620                 


Ser Met His Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr Pro 
625                 630                 635                 640 


Asn Cys Ala Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val Ala 
                645                 650                 655     


Cys Glu Gly Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val Glu 
            660                 665                 670         


Asp Ser Thr 
        675 


<210>  5
<211>  414
<212>  DNA
<213>  Homo sapiens

<400>  5
gatatccctt ccctgggcaa ggaatcccgg gccaagaaat tccagcggca gcatatggac       60

tcagacagtt cccccagcag cagctccacc tactgtaacc aaatgatgag gcgccggaat      120

atgacacagg ggcggtgcaa accagtgaac acctttgtgc acgagcccct ggtagatgtc      180

cagaatgtct gtttccagga aaaggtcacc tgcaagaacg ggcagggcaa ctgctacaag      240

agcaactcca gcatgcacat cacagactgc cgcctgacaa acggctccag gtaccccaac      300

tgtgcatacc ggaccagccc gaaggagaga cacatcattg tggcctgtga agggagccca      360

tatgtgccag tccactttga tgcttctgtg gaggactcta cctaataatc taga            414


<210>  6
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  6

Asp Ile Pro Ser Leu Gly Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg 
1               5                   10                  15      


Gln His Met Asp Ser Asp Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys 
            20                  25                  30          


Asn Gln Met Met Arg Arg Arg Asn Met Thr Gln Gly Arg Cys Lys Pro 
        35                  40                  45              


Val Asn Thr Phe Val His Glu Pro Leu Val Asp Val Gln Asn Val Cys 
    50                  55                  60                  


Phe Gln Glu Lys Val Thr Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys 
65                  70                  75                  80  


Ser Asn Ser Ser Met His Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser 
                85                  90                  95      


Arg Tyr Pro Asn Cys Ala Tyr Arg Thr Ser Pro Lys Glu Arg His Ile 
            100                 105                 110         


Ile Val Ala Cys Glu Gly Ser Pro Tyr Val Pro Val His Phe Asp Ala 
        115                 120                 125             


Ser Val Glu Asp Ser Thr 
    130                 


<210>  7
<211>  462
<212>  DNA
<213>  Artificial

<220>
<223>  3-NLG-WThRNase1 DNA

<400>  7
gtcgacggag ctagcagccc cgtgaacgtg agcagcccca gcgtgcagga tatcccttcc       60

ctgggcaagg aatcccgggc caagaaattc cagcggcagc atatggactc agacagttcc      120

cccagcagca gctccaccta ctgtaaccaa atgatgaggc gccggaatat gacacagggg      180

cggtgcaaac cagtgaacac ctttgtgcac gagcccctgg tagatgtcca gaatgtctgt      240

ttccaggaaa aggtcacctg caagaacggg cagggcaact gctacaagag caactccagc      300

atgcacatca cagactgccg cctgacaaac ggctccaggt accccaactg tgcataccgg      360

accagcccga aggagagaca catcattgtg gcctgtgaag ggagcccata tgtgccagtc      420

cactttgatg cttctgtgga ggactctacc taataatcta ga                         462


<210>  8
<211>  150
<212>  PRT
<213>  Artificial

<220>
<223>  3-NLG-WThRNase1

<400>  8

Val Asp Gly Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln 
1               5                   10                  15      


Asp Ile Pro Ser Leu Gly Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg 
            20                  25                  30          


Gln His Met Asp Ser Asp Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys 
        35                  40                  45              


Asn Gln Met Met Arg Arg Arg Asn Met Thr Gln Gly Arg Cys Lys Pro 
    50                  55                  60                  


Val Asn Thr Phe Val His Glu Pro Leu Val Asp Val Gln Asn Val Cys 
65                  70                  75                  80  


Phe Gln Glu Lys Val Thr Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys 
                85                  90                  95      


Ser Asn Ser Ser Met His Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser 
            100                 105                 110         


Arg Tyr Pro Asn Cys Ala Tyr Arg Thr Ser Pro Lys Glu Arg His Ile 
        115                 120                 125             


Ile Val Ala Cys Glu Gly Ser Pro Tyr Val Pro Val His Phe Asp Ala 
    130                 135                 140                 


Ser Val Glu Asp Ser Thr 
145                 150 


<210>  9
<211>  97
<212>  DNA
<213>  Artificial

<220>
<223>  (g4s)5 linker DNA

<400>  9
agatctctcc ggaggaggtg gctcaggtgg tggaggatct ggaggaggtg gctcaggtgg       60

tggaggatct ggaggaggtg ggagtaccgg tctcgag                                97


<210>  10
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  (g4s)5 linker

<400>  10

Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu 
            20                  25                  30          


<210>  11
<211>  1099
<212>  DNA
<213>  Homo sapiens

<400>  11
atggcgaagc tgattgcgct caccctcttg gggatgggac tggcactctt caggaaccac       60

cagtcttctt accaaacacg acttaatgct ctccgagagg tacaacccgt agaacttcct      120

aactgtaatt tagttaaagg aatcgaaact ggctctgaag acttggagat actgcctaat      180

ggactggctt tcattagctc tggattaaag tatcctggaa taaagagctt caaccccaac      240

agtcctggaa aaatacttct gatggacctg aatgaagaag atccaacagt gttggaattg      300

gggatcactg gaagtaaatt tgatgtatct tcatttaacc ctcatgggat tagcacattc      360

acagatgaag ataatgccat gtacctcctg gtggtgaacc atccagatgc caagtccaca      420

gtggagttgt ttaaatttca agaagaagaa aaatcgcttt tgcatctaaa aaccatcaga      480

cataaacttc tgcctaattt gaatgatatt gttgctgtgg gacctgagca cttttatggc      540

acaaatgatc actattttct tgacccctac ttacaatcct gggagatgta tttgggttta      600

gcgtggtcgt atgttgtcta ctatagtcca agtgaagttc gagtggtggc agaaggattt      660

gattttgcta atggaatcaa catttcaccc gatggcaagt atgtctatat agctgagttg      720

ctggctcata agattcatgt gtatgaaaag catgctaatt ggactttaac tccattgaag      780

tcccttgact ttaataccct cgtggataac atatctgtgg atcctgagac aggagacctt      840

tgggttggat gccatcccaa tggcatgaaa atcttcttct atgactcaga gaatcctcct      900

gcatcagagg tgcttcgaat ccagaacatt ctaacagaag aacctaaagt gacacaggtt      960

tatgcagaaa atggcacagt gttgcaaggc agtacagttg cctctgtgta caaagggaaa     1020

ctgctgattg gcacagtgtt tcacaaagct ctttactgtg agctctaaca gaccgatttg     1080

cacccatgcc atagaaact                                                  1099


<210>  12
<211>  355
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(15)

<400>  12

Met Ala Lys Leu Ile Ala Leu Thr Leu Leu Gly Met Gly Leu Ala Leu 
1               5                   10                  15      


Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg 
            20                  25                  30          


Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile 
        35                  40                  45              


Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn 
65                  70                  75                  80  


Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe 
            100                 105                 110         


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Gln 
            180                 185                 190         


Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr 
        195                 200                 205             


Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu 
        355 


<210>  13
<211>  525
<212>  PRT
<213>  Artificial

<220>
<223>  hWTAPO1-(g4s)4-mthIgG with proline at Eu position 331 in Fc 
       region

<400>  13

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 
    290                 295                 300                 


Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu 
305                 310                 315                 320 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                325                 330                 335     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            340                 345                 350         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        355                 360                 365             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    370                 375                 380                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
385                 390                 395                 400 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                405                 410                 415     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            420                 425                 430         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        435                 440                 445             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    450                 455                 460                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
465                 470                 475                 480 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                485                 490                 495     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            500                 505                 510         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        515                 520                 525 


<210>  14
<211>  675
<212>  PRT
<213>  Artificial

<220>
<223>  hWTAPO1-(g4s)4-mthIgG-hRNase1 with proline at Eu position 331 in 
       Fc region

<400>  14

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 
    290                 295                 300                 


Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu 
305                 310                 315                 320 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                325                 330                 335     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            340                 345                 350         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        355                 360                 365             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    370                 375                 380                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
385                 390                 395                 400 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                405                 410                 415     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            420                 425                 430         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        435                 440                 445             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    450                 455                 460                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
465                 470                 475                 480 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                485                 490                 495     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            500                 505                 510         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly 
        515                 520                 525             


Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Pro 
    530                 535                 540                 


Ser Leu Gly Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His Met 
545                 550                 555                 560 


Asp Ser Asp Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln Met 
                565                 570                 575     


Met Arg Arg Arg Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn Thr 
            580                 585                 590         


Phe Val His Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln Glu 
        595                 600                 605             


Lys Val Thr Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn Ser 
    610                 615                 620                 


Ser Met His Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr Pro 
625                 630                 635                 640 


Asn Cys Ala Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val Ala 
                645                 650                 655     


Cys Glu Gly Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val Glu 
            660                 665                 670         


Asp Ser Thr 
        675 


<210>  15
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  15

Gly Gly Gly Gly Ser 
1               5   


<210>  16
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  sequencing primer

<400>  16
ggttttggca gtacatcaat gg                                                22


<210>  17
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  sequencing primer

<400>  17
ctattgtctt cccaatcctc cc                                                22


<210>  18
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  sequencing primer

<400>  18
accttgcact tgtactcctt                                                   20


<210>  19
<211>  1531
<212>  DNA
<213>  Artificial

<220>
<223>  THER0 DNA (apo A-1-(lnk2)-mthIgG; apo A-1-mthIgG)

<400>  19
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc tcgagcccaa atcttctgac      840

aaaactcaca catctccacc gtccccagca cctgaactcc tgggaggatc gtcagtcttc      900

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      960

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc     1020

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt     1080

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc     1140

aaggtctcca acaaagccct cccagcctcc atcgagaaaa ccatctccaa agccaaaggg     1200

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1260

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1320

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1380

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1440

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1500

tctctctctc cgggtaaatg ataatctaga a                                    1531


<210>  20
<211>  501
<212>  PRT
<213>  Artificial

<220>
<223>  THER0 polypeptide (apo A-1-(lnk2)-mthIgG; apo A-1-mthIgG)

<400>  20

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Glu Pro Lys 
            260                 265                 270         


Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu 
        275                 280                 285             


Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    290                 295                 300                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
305                 310                 315                 320 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                325                 330                 335     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            340                 345                 350         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        355                 360                 365             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    370                 375                 380                 


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
385                 390                 395                 400 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                405                 410                 415     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            420                 425                 430         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        435                 440                 445             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    450                 455                 460                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
465                 470                 475                 480 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                485                 490                 495     


Leu Ser Pro Gly Lys 
            500     


<210>  21
<211>  1573
<212>  DNA
<213>  Artificial

<220>
<223>  THER2 DNA (apo A-1-(lnk16)-mthIgG; apo A-1-(g4s)2-mthIgG)

<400>  21
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc tctccggagg aggtggctca      840

ggaggaggtg ggagtaccgg tctcgagccc aaatcttctg acaaaactca cacatctcca      900

ccgtccccag cacctgaact cctgggagga tcgtcagtct tcctcttccc cccaaaaccc      960

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc     1020

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1080

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1140

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1200

ctcccagcct ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1260

gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc     1320

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1380

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1440

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1500

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctctctctc tccgggtaaa     1560

tgataatcta gaa                                                        1573


<210>  22
<211>  515
<212>  PRT
<213>  Artificial

<220>
<223>  THER2 polypeptide (apo A-1-(lnk16)-mthIgG; apo A-1-(g4s)2-mthIgG)

<400>  22

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser 
        275                 280                 285             


Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly 
    290                 295                 300                 


Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
305                 310                 315                 320 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                325                 330                 335     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            340                 345                 350         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        355                 360                 365             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    370                 375                 380                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile 
385                 390                 395                 400 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                405                 410                 415     


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
            420                 425                 430         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        435                 440                 445             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    450                 455                 460                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
465                 470                 475                 480 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                485                 490                 495     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            500                 505                 510         


Pro Gly Lys 
        515 


<210>  23
<211>  1633
<212>  DNA
<213>  Artificial

<220>
<223>  THER6 DNA (apo A-1-(lnk36)-mthIgG; apo A-1-(g4s)6-mthIgG)

<400>  23
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc tctccggagg aggtggctca      840

ggtggtggag gatctggagg aggtgggagt ggtggaggtg gttctggagg aggtggtagt      900

ggaggtggag gttctaccgg tctcgagccc aaatcttctg acaaaactca cacatctcca      960

ccgtccccag cacctgaact cctgggagga tcgtcagtct tcctcttccc cccaaaaccc     1020

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc     1080

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1140

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1200

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1260

ctcccagcct ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1320

gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc     1380

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1440

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1500

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1560

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctctctctc tccgggtaaa     1620

tgataatcta gaa                                                        1633


<210>  24
<211>  535
<212>  PRT
<213>  Artificial

<220>
<223>  THER6 polypeptide (apo A-1-(lnk36)-mthIgG; apo A-1-(g4s)6-mthIgG)

<400>  24

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu 
    290                 295                 300                 


Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro 
305                 310                 315                 320 


Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                325                 330                 335     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            340                 345                 350         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        355                 360                 365             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    370                 375                 380                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
385                 390                 395                 400 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                405                 410                 415     


Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            420                 425                 430         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        435                 440                 445             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    450                 455                 460                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
465                 470                 475                 480 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                485                 490                 495     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            500                 505                 510         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        515                 520                 525             


Leu Ser Leu Ser Pro Gly Lys 
    530                 535 


<210>  25
<211>  1588
<212>  DNA
<213>  Artificial

<220>
<223>  THER3 DNA (apo A-1-(lnk21)-mthIgG; apo A-1-(g4s)3-mthIgG)

<400>  25
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc tctcaggtgg tggaggatct      840

ggaggaggtg ggagtggtgg aggtggttct accggtctcg agcccaaatc ttctgacaaa      900

actcacacat ctccaccgtc cccagcacct gaactcctgg gaggatcgtc agtcttcctc      960

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg     1020

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     1080

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     1140

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1200

gtctccaaca aagccctccc agcctccatc gagaaaacca tctccaaagc caaagggcag     1260

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     1320

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1380

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1440

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1500

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctct     1560

ctctctccgg gtaaatgata atctagaa                                        1588


<210>  26
<211>  520
<212>  PRT
<213>  Artificial

<220>
<223>  THER3 polypeptide (apo A-1-(lnk21)-mthIgG; apo A-1-(g4s)3-mthIgG)

<400>  26

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu 
        275                 280                 285             


Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala 
    290                 295                 300                 


Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro 
305                 310                 315                 320 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                325                 330                 335     


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            340                 345                 350         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        355                 360                 365             


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    370                 375                 380                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
385                 390                 395                 400 


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                405                 410                 415     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
            420                 425                 430         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        435                 440                 445             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    450                 455                 460                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
465                 470                 475                 480 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                485                 490                 495     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            500                 505                 510         


Ser Leu Ser Leu Ser Pro Gly Lys 
        515                 520 


<210>  27
<211>  2677
<212>  DNA
<213>  Artificial

<220>
<223>  THER4PON1 DNA

<400>  27
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc tctccggagg aggtggctca      840

ggtggtggag gatctggagg aggtgggagt ggtggaggtg gttctaccgg tctcgagccc      900

aaatcttctg acaaaactca cacatctcca ccgtccccag cacctgaact cctgggagga      960

tcgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     1020

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg     1080

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     1140

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1200

gagtacaagt gcaaggtctc caacaaagcc ctcccagcct ccatcgagaa aaccatctcc     1260

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1320

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1380

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1440

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1500

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1560

cagaagagcc tctctctctc tccgggtaaa gtcgacggag ctagcagccc cgtgaacgtg     1620

agcagcccca gcgtgcagga tatcctcttc aggaaccacc agtcttctta ccaaacacga     1680

cttaatgctc tccgagaggt acaacccgta gaacttccta actgtaattt agttaaagga     1740

atcgaaactg gctctgaaga cttggagata ctgcctaatg gactggcttt cattagctct     1800

ggattaaagt atcctggaat aaagagcttc aaccccaaca gtcctggaaa aatacttctg     1860

atggacctga atgaagaaga tccaacagtg ttggaattgg ggatcactgg aagtaaattt     1920

gatgtatctt catttaaccc tcatgggatt agcacattca cagatgaaga taatgccatg     1980

tacctcctgg tggtgaacca tccagatgcc aagtccacag tggagttgtt taaatttcaa     2040

gaagaagaaa aatcgctttt gcatctaaaa accatcagac ataaacttct gcctaatttg     2100

aatgatattg ttgctgtggg acctgagcac ttttatggca caaatgatca ctattttctt     2160

gacccctact tacaatcctg ggagatgtat ttgggtttag cgtggtcgta tgttgtctac     2220

tatagtccaa gtgaagttcg agtggtggca gaaggatttg attttgctaa tggaatcaac     2280

atttcacccg atggcaagta tgtctatata gctgagttgc tggctcataa gattcatgtg     2340

tatgaaaagc atgctaattg gactttaact ccattgaagt cccttgactt taataccctc     2400

gtggataaca tatctgtgga tcctgagaca ggagaccttt gggttggatg ccatcccaat     2460

ggcatgaaaa tcttcttcta tgactcagag aatcctcctg catcagaggt gcttcgaatc     2520

cagaacattc taacagaaga acctaaagtg acacaggttt atgcagaaaa tggcacagtg     2580

ttgcaaggca gtacagttgc ctctgtgtac aaagggaaac tgctgattgg cacagtgttt     2640

cacaaagctc tttactgtga gctctaataa tctagaa                              2677


<210>  28
<211>  883
<212>  PRT
<213>  Artificial

<220>
<223>  THER4PON1 polypeptide

<400>  28

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 
    290                 295                 300                 


Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu 
305                 310                 315                 320 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                325                 330                 335     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            340                 345                 350         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        355                 360                 365             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    370                 375                 380                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
385                 390                 395                 400 


Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys 
                405                 410                 415     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            420                 425                 430         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        435                 440                 445             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    450                 455                 460                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
465                 470                 475                 480 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                485                 490                 495     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            500                 505                 510         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly 
        515                 520                 525             


Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Leu 
    530                 535                 540                 


Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg 
545                 550                 555                 560 


Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile 
                565                 570                 575     


Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
            580                 585                 590         


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn 
        595                 600                 605             


Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr 
    610                 615                 620                 


Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe 
625                 630                 635                 640 


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr 
                645                 650                 655     


Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe 
            660                 665                 670         


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
        675                 680                 685             


His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu 
    690                 695                 700                 


His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Gln 
705                 710                 715                 720 


Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr 
                725                 730                 735     


Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
            740                 745                 750         


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
        755                 760                 765             


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
    770                 775                 780                 


Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser 
785                 790                 795                 800 


Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
                805                 810                 815     


Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val 
            820                 825                 830         


Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val 
        835                 840                 845             


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val 
    850                 855                 860                 


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
865                 870                 875                 880 


Cys Glu Leu 
            


<210>  29
<211>  1717
<212>  DNA
<213>  Homo sapiens

<400>  29
atatacgggc tccaggctga acggctcggg ccacttacac accactgcct gataaccatg       60

ctggctgcca cagtcctgac cctggccctg ctgggcaatg cccatgcctg ctccaaaggc      120

acctcgcacg aggcaggcat cgtgtgccgc atcaccaagc ctgccctcct ggtgttgaac      180

cacgagactg ccaaggtgat ccagaccgcc ttccagcgag ccagctaccc agatatcacg      240

ggcgagaagg ccatgatgct ccttggccaa gtcaagtatg ggttgcacaa catccagatc      300

agccacttgt ccatcgccag cagccaggtg gagctggtgg aagccaagtc cattgatgtc      360

tccattcaga acgtgtctgt ggtcttcaag gggaccctga agtatggcta caccactgcc      420

tggtggctgg gtattgatca gtccattgac ttcgagatcg actctgccat tgacctccag      480

atcaacacac agctgacctg tgactctggt agagtgcgga ccgatgcccc tgactgctac      540

ctgtctttcc ataagctgct cctgcatctc caaggggagc gagagcctgg gtggatcaag      600

cagctgttca caaatttcat ctccttcacc ctgaagctgg tcctgaaggg acagatctgc      660

aaagagatca acgtcatctc taacatcatg gccgattttg tccagacaag ggctgccagc      720

atcctttcag atggagacat tggggtggac atttccctga caggtgatcc cgtcatcaca      780

gcctcctacc tggagtccca tcacaagggt catttcatct acaagaatgt ctcagaggac      840

ctccccctcc ccaccttctc gcccacactg ctgggggact cccgcatgct gtacttctgg      900

ttctctgagc gagtcttcca ctcgctggcc aaggtagctt tccaggatgg ccgcctcatg      960

ctcagcctga tgggagacga gttcaaggca gtgctggaga cctggggctt caacaccaac     1020

caggaaatct tccaagaggt tgtcggcggc ttccccagcc aggcccaagt caccgtccac     1080

tgcctcaaga tgcccaagat ctcctgccaa aacaagggag tcgtggtcaa ttcttcagtg     1140

atggtgaaat tcctctttcc acgcccagac cagcaacatt ctgtagctta cacatttgaa     1200

gaggatatcg tgactaccgt ccaggcctcc tattctaaga aaaagctctt cttaagcctc     1260

ttggatttcc agattacacc aaagactgtt tccaacttga ctgagagcag ctccgagtcc     1320

gtccagagct tcctgcagtc aatgatcacc gctgtgggca tccctgaggt catgtctcgg     1380

ctcgaggtag tgtttacagc cctcatgaac agcaaaggcg tgagcctctt cgacatcatc     1440

aaccctgaga ttatcactcg agatggcttc ctgctgctgc agatggactt tggcttccct     1500

gagcacctgc tggtggattt cctccagagc ttgagctaga agtctccaag gaggtcggga     1560

tggggcttgt agcagaaggc aagcaccagg ctcacagctg gaaccctggt gtctcctcca     1620

gcgtggtgga agttgggtta ggagtacgga gatggagatt ggctcccaac tcctccctat     1680

cctaaaggcc cactggcatt aaagtgctgt atccaag                              1717


<210>  30
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Ser Lys Gly Thr Ser His Glu Ala Gly Ile Val Cys Arg Ile 
            20                  25                  30          


Thr Lys Pro Ala Leu Leu Val Leu Asn His Glu Thr Ala Lys Val Ile 
        35                  40                  45              


Gln Thr Ala Phe Gln Arg Ala Ser Tyr Pro Asp Ile Thr Gly Glu Lys 
    50                  55                  60                  


Ala Met Met Leu Leu Gly Gln Val Lys Tyr Gly Leu His Asn Ile Gln 
65                  70                  75                  80  


Ile Ser His Leu Ser Ile Ala Ser Ser Gln Val Glu Leu Val Glu Ala 
                85                  90                  95      


Lys Ser Ile Asp Val Ser Ile Gln Asn Val Ser Val Val Phe Lys Gly 
            100                 105                 110         


Thr Leu Lys Tyr Gly Tyr Thr Thr Ala Trp Trp Leu Gly Ile Asp Gln 
        115                 120                 125             


Ser Ile Asp Phe Glu Ile Asp Ser Ala Ile Asp Leu Gln Ile Asn Thr 
    130                 135                 140                 


Gln Leu Thr Cys Asp Ser Gly Arg Val Arg Thr Asp Ala Pro Asp Cys 
145                 150                 155                 160 


Tyr Leu Ser Phe His Lys Leu Leu Leu His Leu Gln Gly Glu Arg Glu 
                165                 170                 175     


Pro Gly Trp Ile Lys Gln Leu Phe Thr Asn Phe Ile Ser Phe Thr Leu 
            180                 185                 190         


Lys Leu Val Leu Lys Gly Gln Ile Cys Lys Glu Ile Asn Val Ile Ser 
        195                 200                 205             


Asn Ile Met Ala Asp Phe Val Gln Thr Arg Ala Ala Ser Ile Leu Ser 
    210                 215                 220                 


Asp Gly Asp Ile Gly Val Asp Ile Ser Leu Thr Gly Asp Pro Val Ile 
225                 230                 235                 240 


Thr Ala Ser Tyr Leu Glu Ser His His Lys Gly His Phe Ile Tyr Lys 
                245                 250                 255     


Asn Val Ser Glu Asp Leu Pro Leu Pro Thr Phe Ser Pro Thr Leu Leu 
            260                 265                 270         


Gly Asp Ser Arg Met Leu Tyr Phe Trp Phe Ser Glu Arg Val Phe His 
        275                 280                 285             


Ser Leu Ala Lys Val Ala Phe Gln Asp Gly Arg Leu Met Leu Ser Leu 
    290                 295                 300                 


Met Gly Asp Glu Phe Lys Ala Val Leu Glu Thr Trp Gly Phe Asn Thr 
305                 310                 315                 320 


Asn Gln Glu Ile Phe Gln Glu Val Val Gly Gly Phe Pro Ser Gln Ala 
                325                 330                 335     


Gln Val Thr Val His Cys Leu Lys Met Pro Lys Ile Ser Cys Gln Asn 
            340                 345                 350         


Lys Gly Val Val Val Asn Ser Ser Val Met Val Lys Phe Leu Phe Pro 
        355                 360                 365             


Arg Pro Asp Gln Gln His Ser Val Ala Tyr Thr Phe Glu Glu Asp Ile 
    370                 375                 380                 


Val Thr Thr Val Gln Ala Ser Tyr Ser Lys Lys Lys Leu Phe Leu Ser 
385                 390                 395                 400 


Leu Leu Asp Phe Gln Ile Thr Pro Lys Thr Val Ser Asn Leu Thr Glu 
                405                 410                 415     


Ser Ser Ser Glu Ser Val Gln Ser Phe Leu Gln Ser Met Ile Thr Ala 
            420                 425                 430         


Val Gly Ile Pro Glu Val Met Ser Arg Leu Glu Val Val Phe Thr Ala 
        435                 440                 445             


Leu Met Asn Ser Lys Gly Val Ser Leu Phe Asp Ile Ile Asn Pro Glu 
    450                 455                 460                 


Ile Ile Thr Arg Asp Gly Phe Leu Leu Leu Gln Met Asp Phe Gly Phe 
465                 470                 475                 480 


Pro Glu His Leu Leu Val Asp Phe Leu Gln Ser Leu Ser 
                485                 490             


<210>  31
<211>  1880
<212>  DNA
<213>  Homo sapiens

<400>  31
gggtcggggc cacaaggccg cgctaggcgg acccaggaca cagcccgcgc gcagcccacc       60

cgcccgccgc ctgccagagc tgctcggccc gcagccaggg ggacagcggc tggtcggagg      120

ctcgcagtgc tgtcggcgag aagcagtcgg gtttggagcg cttgggtcgc gttggtgcgc      180

ggtggaacgc gcccagggac cccagttccc gcgagcagct ccgcgccgcg cctgagagac      240

taagctgaaa ctgctgctca gctcccaaga tggtgccacc caaattgcat gtgcttttct      300

gcctctgcgg ctgcctggct gtggtttatc cttttgactg gcaatacata aatcctgttg      360

cccatatgaa atcatcagca tgggtcaaca aaatacaagt actgatggct gctgcaagct      420

ttggccaaac taaaatcccc cggggaaatg ggccttattc cgttggttgt acagacttaa      480

tgtttgatca cactaataag ggcaccttct tgcgtttata ttatccatcc caagataatg      540

atcgccttga caccctttgg atcccaaata aagaatattt ttggggtctt agcaaatttc      600

ttggaacaca ctggcttatg ggcaacattt tgaggttact ctttggttca atgacaactc      660

ctgcaaactg gaattcccct ctgaggcctg gtgaaaaata tccacttgtt gttttttctc      720

atggtcttgg ggcattcagg acactttatt ctgctattgg cattgacctg gcatctcatg      780

ggtttatagt tgctgctgta gaacacagag atagatctgc atctgcaact tactatttca      840

aggaccaatc tgctgcagaa ataggggaca agtcttggct ctaccttaga accctgaaac      900

aagaggagga gacacatata cgaaatgagc aggtacggca aagagcaaaa gaatgttccc      960

aagctctcag tctgattctt gacattgatc atggaaagcc agtgaagaat gcattagatt     1020

taaagtttga tatggaacaa ctgaaggact ctattgatag ggaaaaaata gcagtaattg     1080

gacattcttt tggtggagca acggttattc agactcttag tgaagatcag agattcagat     1140

gtggtattgc cctggatgca tggatgtttc cactgggtga tgaagtatat tccagaattc     1200

ctcagcccct cttttttatc aactctgaat atttccaata tcctgctaat atcataaaaa     1260

tgaaaaaatg ctactcacct gataaagaaa gaaagatgat tacaatcagg ggttcagtcc     1320

accagaattt tgctgacttc acttttgcaa ctggcaaaat aattggacac atgctcaaat     1380

taaagggaga catagattca aatgtagcta ttgatcttag caacaaagct tcattagcat     1440

tcttacaaaa gcatttagga cttcataaag attttgatca gtgggactgc ttgattgaag     1500

gagatgatga gaatcttatt ccagggacca acattaacac aaccaatcaa cacatcatgt     1560

tacagaactc ttcaggaata gagaaataca attaggatta aaataggttt tttaaaagtc     1620

ttgtttcaaa actgtctaaa attatgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgagag     1680

agagagagag agagagagag agagagagag agaattttaa tgtattttcc caaaggactc     1740

atattttaaa atgtaggcta tactgtaatc gtgattgaag cttggactaa gaattttttc     1800

cctttagatg taaagaaaga atacagtata caatattcaa aaaaaaaaaa aaaaaaaaaa     1860

aaaaaaaaaa aaaaaaaaaa                                                 1880


<210>  32
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Val Pro Pro Lys Leu His Val Leu Phe Cys Leu Cys Gly Cys Leu 
1               5                   10                  15      


Ala Val Val Tyr Pro Phe Asp Trp Gln Tyr Ile Asn Pro Val Ala His 
            20                  25                  30          


Met Lys Ser Ser Ala Trp Val Asn Lys Ile Gln Val Leu Met Ala Ala 
        35                  40                  45              


Ala Ser Phe Gly Gln Thr Lys Ile Pro Arg Gly Asn Gly Pro Tyr Ser 
    50                  55                  60                  


Val Gly Cys Thr Asp Leu Met Phe Asp His Thr Asn Lys Gly Thr Phe 
65                  70                  75                  80  


Leu Arg Leu Tyr Tyr Pro Ser Gln Asp Asn Asp Arg Leu Asp Thr Leu 
                85                  90                  95      


Trp Ile Pro Asn Lys Glu Tyr Phe Trp Gly Leu Ser Lys Phe Leu Gly 
            100                 105                 110         


Thr His Trp Leu Met Gly Asn Ile Leu Arg Leu Leu Phe Gly Ser Met 
        115                 120                 125             


Thr Thr Pro Ala Asn Trp Asn Ser Pro Leu Arg Pro Gly Glu Lys Tyr 
    130                 135                 140                 


Pro Leu Val Val Phe Ser His Gly Leu Gly Ala Phe Arg Thr Leu Tyr 
145                 150                 155                 160 


Ser Ala Ile Gly Ile Asp Leu Ala Ser His Gly Phe Ile Val Ala Ala 
                165                 170                 175     


Val Glu His Arg Asp Arg Ser Ala Ser Ala Thr Tyr Tyr Phe Lys Asp 
            180                 185                 190         


Gln Ser Ala Ala Glu Ile Gly Asp Lys Ser Trp Leu Tyr Leu Arg Thr 
        195                 200                 205             


Leu Lys Gln Glu Glu Glu Thr His Ile Arg Asn Glu Gln Val Arg Gln 
    210                 215                 220                 


Arg Ala Lys Glu Cys Ser Gln Ala Leu Ser Leu Ile Leu Asp Ile Asp 
225                 230                 235                 240 


His Gly Lys Pro Val Lys Asn Ala Leu Asp Leu Lys Phe Asp Met Glu 
                245                 250                 255     


Gln Leu Lys Asp Ser Ile Asp Arg Glu Lys Ile Ala Val Ile Gly His 
            260                 265                 270         


Ser Phe Gly Gly Ala Thr Val Ile Gln Thr Leu Ser Glu Asp Gln Arg 
        275                 280                 285             


Phe Arg Cys Gly Ile Ala Leu Asp Ala Trp Met Phe Pro Leu Gly Asp 
    290                 295                 300                 


Glu Val Tyr Ser Arg Ile Pro Gln Pro Leu Phe Phe Ile Asn Ser Glu 
305                 310                 315                 320 


Tyr Phe Gln Tyr Pro Ala Asn Ile Ile Lys Met Lys Lys Cys Tyr Ser 
                325                 330                 335     


Pro Asp Lys Glu Arg Lys Met Ile Thr Ile Arg Gly Ser Val His Gln 
            340                 345                 350         


Asn Phe Ala Asp Phe Thr Phe Ala Thr Gly Lys Ile Ile Gly His Met 
        355                 360                 365             


Leu Lys Leu Lys Gly Asp Ile Asp Ser Asn Val Ala Ile Asp Leu Ser 
    370                 375                 380                 


Asn Lys Ala Ser Leu Ala Phe Leu Gln Lys His Leu Gly Leu His Lys 
385                 390                 395                 400 


Asp Phe Asp Gln Trp Asp Cys Leu Ile Glu Gly Asp Asp Glu Asn Leu 
                405                 410                 415     


Ile Pro Gly Thr Asn Ile Asn Thr Thr Asn Gln His Ile Met Leu Gln 
            420                 425                 430         


Asn Ser Ser Gly Ile Glu Lys Tyr Asn 
        435                 440     


<210>  33
<211>  2907
<212>  DNA
<213>  Artificial

<220>
<223>  THER4PAFAH DNA

<400>  33
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc tctccggagg aggtggctca      840

ggtggtggag gatctggagg aggtgggagt ggtggaggtg gttctaccgg tctcgagccc      900

aaatcttctg acaaaactca cacatctcca ccgtccccag cacctgaact cctgggagga      960

tcgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     1020

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg     1080

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     1140

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1200

gagtacaagt gcaaggtctc caacaaagcc ctcccagcct ccatcgagaa aaccatctcc     1260

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1320

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1380

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1440

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1500

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1560

cagaagagcc tctctctctc tccgggtaaa gtcgacggag ctagcagccc cgtgaacgtg     1620

agcagcccca gcgtgcagga tatctttgac tggcaataca taaatcctgt tgcccatatg     1680

aaatcatcag catgggtcaa caaaatacaa gtactgatgg ctgctgcaag ctttggccaa     1740

actaaaatcc cccggggaaa tgggccttat tccgttggtt gtacagactt aatgtttgat     1800

cacactaata agggcacctt cttgcgttta tattatccat cccaagataa tgatcgcctt     1860

gacacccttt ggatcccaaa taaagaatat ttttggggtc ttagcaaatt tcttggaaca     1920

cactggctta tgggcaacat tttgaggtta ctctttggtt caatgacaac tcctgcaaac     1980

tggaattccc ctctgaggcc tggtgaaaaa tatccacttg ttgttttttc tcatggtctt     2040

ggggcattca ggacacttta ttctgctatt ggcattgacc tggcatctca tgggtttata     2100

gttgctgctg tagaacacag agatagatct gcatctgcaa cttactattt caaggaccaa     2160

tctgctgcag aaatagggga caagtcttgg ctctacctta gaaccctgaa acaagaggag     2220

gagacacata tacgaaatga gcaggtacgg caaagagcaa aagaatgttc ccaagctctc     2280

agtctgattc ttgacattga tcatggaaag ccagtgaaga atgcattaga tttaaagttt     2340

gatatggaac aactgaagga ctctattgat agggaaaaaa tagcagtaat tggacattct     2400

tttggtggag caacggttat tcagactctt agtgaagatc agagattcag atgtggtatt     2460

gccctggatg catggatgtt tccactgggt gatgaagtat attccagaat tcctcagccc     2520

ctctttttta tcaactctga atatttccaa tatcctgcta atatcataaa aatgaaaaaa     2580

tgctactcac ctgataaaga aagaaagatg attacaatca ggggttcagt ccaccagaat     2640

tttgctgact tcacttttgc aactggcaaa ataattggac acatgctcaa attaaaggga     2700

gacatagatt caaatgtagc tattgatctt agcaacaaag cttcattagc attcttacaa     2760

aagcatttag gacttcataa agattttgat cagtgggact gcttgattga aggagatgat     2820

gagaatctta ttccagggac caacattaac acaaccaatc aacacatcat gttacagaac     2880

tcttcaggaa tagagaaata caattag                                         2907


<210>  34
<211>  963
<212>  PRT
<213>  Artificial

<220>
<223>  THER4PAFAH polypeptide

<400>  34

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 
    290                 295                 300                 


Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu 
305                 310                 315                 320 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                325                 330                 335     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            340                 345                 350         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        355                 360                 365             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    370                 375                 380                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
385                 390                 395                 400 


Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys 
                405                 410                 415     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            420                 425                 430         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        435                 440                 445             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    450                 455                 460                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
465                 470                 475                 480 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                485                 490                 495     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            500                 505                 510         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly 
        515                 520                 525             


Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Phe 
    530                 535                 540                 


Asp Trp Gln Tyr Ile Asn Pro Val Ala His Met Lys Ser Ser Ala Trp 
545                 550                 555                 560 


Val Asn Lys Ile Gln Val Leu Met Ala Ala Ala Ser Phe Gly Gln Thr 
                565                 570                 575     


Lys Ile Pro Arg Gly Asn Gly Pro Tyr Ser Val Gly Cys Thr Asp Leu 
            580                 585                 590         


Met Phe Asp His Thr Asn Lys Gly Thr Phe Leu Arg Leu Tyr Tyr Pro 
        595                 600                 605             


Ser Gln Asp Asn Asp Arg Leu Asp Thr Leu Trp Ile Pro Asn Lys Glu 
    610                 615                 620                 


Tyr Phe Trp Gly Leu Ser Lys Phe Leu Gly Thr His Trp Leu Met Gly 
625                 630                 635                 640 


Asn Ile Leu Arg Leu Leu Phe Gly Ser Met Thr Thr Pro Ala Asn Trp 
                645                 650                 655     


Asn Ser Pro Leu Arg Pro Gly Glu Lys Tyr Pro Leu Val Val Phe Ser 
            660                 665                 670         


His Gly Leu Gly Ala Phe Arg Thr Leu Tyr Ser Ala Ile Gly Ile Asp 
        675                 680                 685             


Leu Ala Ser His Gly Phe Ile Val Ala Ala Val Glu His Arg Asp Arg 
    690                 695                 700                 


Ser Ala Ser Ala Thr Tyr Tyr Phe Lys Asp Gln Ser Ala Ala Glu Ile 
705                 710                 715                 720 


Gly Asp Lys Ser Trp Leu Tyr Leu Arg Thr Leu Lys Gln Glu Glu Glu 
                725                 730                 735     


Thr His Ile Arg Asn Glu Gln Val Arg Gln Arg Ala Lys Glu Cys Ser 
            740                 745                 750         


Gln Ala Leu Ser Leu Ile Leu Asp Ile Asp His Gly Lys Pro Val Lys 
        755                 760                 765             


Asn Ala Leu Asp Leu Lys Phe Asp Met Glu Gln Leu Lys Asp Ser Ile 
    770                 775                 780                 


Asp Arg Glu Lys Ile Ala Val Ile Gly His Ser Phe Gly Gly Ala Thr 
785                 790                 795                 800 


Val Ile Gln Thr Leu Ser Glu Asp Gln Arg Phe Arg Cys Gly Ile Ala 
                805                 810                 815     


Leu Asp Ala Trp Met Phe Pro Leu Gly Asp Glu Val Tyr Ser Arg Ile 
            820                 825                 830         


Pro Gln Pro Leu Phe Phe Ile Asn Ser Glu Tyr Phe Gln Tyr Pro Ala 
        835                 840                 845             


Asn Ile Ile Lys Met Lys Lys Cys Tyr Ser Pro Asp Lys Glu Arg Lys 
    850                 855                 860                 


Met Ile Thr Ile Arg Gly Ser Val His Gln Asn Phe Ala Asp Phe Thr 
865                 870                 875                 880 


Phe Ala Thr Gly Lys Ile Ile Gly His Met Leu Lys Leu Lys Gly Asp 
                885                 890                 895     


Ile Asp Ser Asn Val Ala Ile Asp Leu Ser Asn Lys Ala Ser Leu Ala 
            900                 905                 910         


Phe Leu Gln Lys His Leu Gly Leu His Lys Asp Phe Asp Gln Trp Asp 
        915                 920                 925             


Cys Leu Ile Glu Gly Asp Asp Glu Asn Leu Ile Pro Gly Thr Asn Ile 
    930                 935                 940                 


Asn Thr Thr Asn Gln His Ile Met Leu Gln Asn Ser Ser Gly Ile Glu 
945                 950                 955                 960 


Lys Tyr Asn 
            


<210>  35
<211>  801
<212>  DNA
<213>  Homo sapiens

<400>  35
atgaaagctg cggtgctgac cttggccgtg ctcttcctga cggggagcca ggctcggcat       60

ttctggcagc aagatgaacc cccccagagc ccctgggatc gagtgaagga cctggccact      120

gtgtacgtgg atgtgctcaa agacagcggc agagactatg tgtcccagtt tgaaggctcc      180

gccttgggaa aacagctaaa cctaaagctc cttgacaact gggacagcgt gacctccacc      240

ttcagcaagc tgcgcgaaca gctcggccct gtgacccagg agttctggga taacctggaa      300

aaggagacag agggcctgag gcaggagatg agcaaggatc tggaggaggt gaaggccaag      360

gtgcagccct acctggacga cttccagaag aagtggcagg aggagatgga gctctaccgc      420

cagaaggtgg agccgctgcg cgcagagctc caagagggcg cgcgccagaa gctgcacgag      480

ctgcaagaga agctgagccc actgggcgag gagatgcgcg accgcgcgcg cgcccatgtg      540

gacgcgctgc gcacgcatct ggccccctac agcgacgagc tgcgccagcg cttggccgcg      600

cgccttgagg ctctcaagga gaacggcggc gccagactgg ccgagtacca cgccaaggcc      660

accgagcatc tgagcacgct cagcgagaag gccaagcccg cgctcgagga cctccgccaa      720

ggcctgctgc ccgtgctgga gagcttcaag gtcagcttcc tgagcgctct cgaggagtac      780

actaagaagc tcaacaccca a                                                801


<210>  36
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
            260                 265         


<210>  37
<211>  2647
<212>  DNA
<213>  Artificial

<220>
<223>  THER2PON1 DNA

<400>  37
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc tctccggagg aggtggctca      840

ggaggaggtg ggagtaccgg tctcgagccc aaatcttctg acaaaactca cacatctcca      900

ccgtccccag cacctgaact cctgggagga tcgtcagtct tcctcttccc cccaaaaccc      960

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc     1020

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1080

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1140

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1200

ctcccagcct ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1260

gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc     1320

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1380

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1440

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1500

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctctctctc tccgggtaaa     1560

gtcgacggag ctagcagccc cgtgaacgtg agcagcccca gcgtgcagga tatcctcttc     1620

aggaaccacc agtcttctta ccaaacacga cttaatgctc tccgagaggt acaacccgta     1680

gaacttccta actgtaattt agttaaagga atcgaaactg gctctgaaga cttggagata     1740

ctgcctaatg gactggcttt cattagctct ggattaaagt atcctggaat aaagagcttc     1800

aaccccaaca gtcctggaaa aatacttctg atggacctga atgaagaaga tccaacagtg     1860

ttggaattgg ggatcactgg aagtaaattt gatgtatctt catttaaccc tcatgggatt     1920

agcacattca cagatgaaga taatgccatg tacctcctgg tggtgaacca tccagatgcc     1980

aagtccacag tggagttgtt taaatttcaa gaagaagaaa aatcgctttt gcatctaaaa     2040

accatcagac ataaacttct gcctaatttg aatgatattg ttgctgtggg acctgagcac     2100

ttttatggca caaatgatca ctattttctt gacccctact tacaatcctg ggagatgtat     2160

ttgggtttag cgtggtcgta tgttgtctac tatagtccaa gtgaagttcg agtggtggca     2220

gaaggatttg attttgctaa tggaatcaac atttcacccg atggcaagta tgtctatata     2280

gctgagttgc tggctcataa gattcatgtg tatgaaaagc atgctaattg gactttaact     2340

ccattgaagt cccttgactt taataccctc gtggataaca tatctgtgga tcctgagaca     2400

ggagaccttt gggttggatg ccatcccaat ggcatgaaaa tcttcttcta tgactcagag     2460

aatcctcctg catcagaggt gcttcgaatc cagaacattc taacagaaga acctaaagtg     2520

acacaggttt atgcagaaaa tggcacagtg ttgcaaggca gtacagttgc ctctgtgtac     2580

aaagggaaac tgctgattgg cacagtgttt cacaaagctc tttactgtga gctctaataa     2640

tctagaa                                                               2647


<210>  38
<211>  873
<212>  PRT
<213>  Artificial

<220>
<223>  THER2PON1 polypeptide

<400>  38

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser 
        275                 280                 285             


Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly 
    290                 295                 300                 


Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
305                 310                 315                 320 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                325                 330                 335     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            340                 345                 350         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        355                 360                 365             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    370                 375                 380                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile 
385                 390                 395                 400 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                405                 410                 415     


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
            420                 425                 430         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        435                 440                 445             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    450                 455                 460                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
465                 470                 475                 480 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                485                 490                 495     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            500                 505                 510         


Pro Gly Lys Val Asp Gly Ala Ser Ser Pro Val Asn Val Ser Ser Pro 
        515                 520                 525             


Ser Val Gln Asp Ile Leu Phe Arg Asn His Gln Ser Ser Tyr Gln Thr 
    530                 535                 540                 


Arg Leu Asn Ala Leu Arg Glu Val Gln Pro Val Glu Leu Pro Asn Cys 
545                 550                 555                 560 


Asn Leu Val Lys Gly Ile Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu 
                565                 570                 575     


Pro Asn Gly Leu Ala Phe Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile 
            580                 585                 590         


Lys Ser Phe Asn Pro Asn Ser Pro Gly Lys Ile Leu Leu Met Asp Leu 
        595                 600                 605             


Asn Glu Glu Asp Pro Thr Val Leu Glu Leu Gly Ile Thr Gly Ser Lys 
    610                 615                 620                 


Phe Asp Val Ser Ser Phe Asn Pro His Gly Ile Ser Thr Phe Thr Asp 
625                 630                 635                 640 


Glu Asp Asn Ala Met Tyr Leu Leu Val Val Asn His Pro Asp Ala Lys 
                645                 650                 655     


Ser Thr Val Glu Leu Phe Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu 
            660                 665                 670         


His Leu Lys Thr Ile Arg His Lys Leu Leu Pro Asn Leu Asn Asp Ile 
        675                 680                 685             


Val Ala Val Gly Pro Glu His Phe Tyr Gly Thr Asn Asp His Tyr Phe 
    690                 695                 700                 


Leu Asp Pro Tyr Leu Gln Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp 
705                 710                 715                 720 


Ser Tyr Val Val Tyr Tyr Ser Pro Ser Glu Val Arg Val Val Ala Glu 
                725                 730                 735     


Gly Phe Asp Phe Ala Asn Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr 
            740                 745                 750         


Val Tyr Ile Ala Glu Leu Leu Ala His Lys Ile His Val Tyr Glu Lys 
        755                 760                 765             


His Ala Asn Trp Thr Leu Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr 
    770                 775                 780                 


Leu Val Asp Asn Ile Ser Val Asp Pro Glu Thr Gly Asp Leu Trp Val 
785                 790                 795                 800 


Gly Cys His Pro Asn Gly Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn 
                805                 810                 815     


Pro Pro Ala Ser Glu Val Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu 
            820                 825                 830         


Pro Lys Val Thr Gln Val Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly 
        835                 840                 845             


Ser Thr Val Ala Ser Val Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val 
    850                 855                 860                 


Phe His Lys Ala Leu Tyr Cys Glu Leu 
865                 870             


<210>  39
<211>  3084
<212>  DNA
<213>  Artificial

<220>
<223>  THER4CETP DNA

<400>  39
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc tctccggagg aggtggctca      840

ggtggtggag gatctggagg aggtgggagt ggtggaggtg gttctaccgg tctcgagccc      900

aaatcttctg acaaaactca cacatctcca ccgtccccag cacctgaact cctgggagga      960

tcgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     1020

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg     1080

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     1140

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1200

gagtacaagt gcaaggtctc caacaaagcc ctcccagcct ccatcgagaa aaccatctcc     1260

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1320

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1380

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1440

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1500

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1560

cagaagagcc tctctctctc tccgggtaaa gtcgacggag ctagcagccc cgtgaacgtg     1620

agcagcccca gcgtgcagga tatctgctcc aaaggcacct cgcacgaggc aggcatcgtg     1680

tgccgcatca ccaagcctgc cctcctggtg ttgaaccacg agactgccaa ggtgatccag     1740

accgccttcc agcgagccag ctacccagat atcacgggcg agaaggccat gatgctcctt     1800

ggccaagtca agtatgggtt gcacaacatc cagatcagcc acttgtccat cgccagcagc     1860

caggtggagc tggtggaagc caagtccatt gatgtctcca ttcagaacgt gtctgtggtc     1920

ttcaagggga ccctgaagta tggctacacc actgcctggt ggctgggtat tgatcagtcc     1980

attgacttcg agatcgactc tgccattgac ctccagatca acacacagct gacctgtgac     2040

tctggtagag tgcggaccga tgcccctgac tgctacctgt ctttccataa gctgctcctg     2100

catctccaag gggagcgaga gcctgggtgg atcaagcagc tgttcacaaa tttcatctcc     2160

ttcaccctga agctggtcct gaagggacag atctgcaaag agatcaacgt catctctaac     2220

atcatggccg attttgtcca gacaagggct gccagcatcc tttcagatgg agacattggg     2280

gtggacattt ccctgacagg tgatcccgtc atcacagcct cctacctgga gtcccatcac     2340

aagggtcatt tcatctacaa gaatgtctca gaggacctcc ccctccccac cttctcgccc     2400

acactgctgg gggactcccg catgctgtac ttctggttct ctgagcgagt cttccactcg     2460

ctggccaagg tagctttcca ggatggccgc ctcatgctca gcctgatggg agacgagttc     2520

aaggcagtgc tggagacctg gggcttcaac accaaccagg aaatcttcca agaggttgtc     2580

ggcggcttcc ccagccaggc ccaagtcacc gtccactgcc tcaagatgcc caagatctcc     2640

tgccaaaaca agggagtcgt ggtcaattct tcagtgatgg tgaaattcct ctttccacgc     2700

ccagaccagc aacattctgt agcttacaca tttgaagagg atatcgtgac taccgtccag     2760

gcctcctatt ctaagaaaaa gctcttctta agcctcttgg atttccagat tacaccaaag     2820

actgtttcca acttgactga gagcagctcc gagtccgtcc agagcttcct gcagtcaatg     2880

atcaccgctg tgggcatccc tgaggtcatg tctcggctcg aggtagtgtt tacagccctc     2940

atgaacagca aaggcgtgag cctcttcgac atcatcaacc ctgagattat cactcgagat     3000

ggcttcctgc tgctgcagat ggactttggc ttccctgagc acctgctggt ggatttcctc     3060

cagagcttga gctaataatc taga                                            3084


<210>  40
<211>  1019
<212>  PRT
<213>  Artificial

<220>
<223>  THER4CETP polypeptide

<400>  40

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 
    290                 295                 300                 


Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu 
305                 310                 315                 320 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                325                 330                 335     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            340                 345                 350         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        355                 360                 365             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    370                 375                 380                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
385                 390                 395                 400 


Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys 
                405                 410                 415     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            420                 425                 430         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        435                 440                 445             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    450                 455                 460                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
465                 470                 475                 480 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                485                 490                 495     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            500                 505                 510         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly 
        515                 520                 525             


Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Cys 
    530                 535                 540                 


Ser Lys Gly Thr Ser His Glu Ala Gly Ile Val Cys Arg Ile Thr Lys 
545                 550                 555                 560 


Pro Ala Leu Leu Val Leu Asn His Glu Thr Ala Lys Val Ile Gln Thr 
                565                 570                 575     


Ala Phe Gln Arg Ala Ser Tyr Pro Asp Ile Thr Gly Glu Lys Ala Met 
            580                 585                 590         


Met Leu Leu Gly Gln Val Lys Tyr Gly Leu His Asn Ile Gln Ile Ser 
        595                 600                 605             


His Leu Ser Ile Ala Ser Ser Gln Val Glu Leu Val Glu Ala Lys Ser 
    610                 615                 620                 


Ile Asp Val Ser Ile Gln Asn Val Ser Val Val Phe Lys Gly Thr Leu 
625                 630                 635                 640 


Lys Tyr Gly Tyr Thr Thr Ala Trp Trp Leu Gly Ile Asp Gln Ser Ile 
                645                 650                 655     


Asp Phe Glu Ile Asp Ser Ala Ile Asp Leu Gln Ile Asn Thr Gln Leu 
            660                 665                 670         


Thr Cys Asp Ser Gly Arg Val Arg Thr Asp Ala Pro Asp Cys Tyr Leu 
        675                 680                 685             


Ser Phe His Lys Leu Leu Leu His Leu Gln Gly Glu Arg Glu Pro Gly 
    690                 695                 700                 


Trp Ile Lys Gln Leu Phe Thr Asn Phe Ile Ser Phe Thr Leu Lys Leu 
705                 710                 715                 720 


Val Leu Lys Gly Gln Ile Cys Lys Glu Ile Asn Val Ile Ser Asn Ile 
                725                 730                 735     


Met Ala Asp Phe Val Gln Thr Arg Ala Ala Ser Ile Leu Ser Asp Gly 
            740                 745                 750         


Asp Ile Gly Val Asp Ile Ser Leu Thr Gly Asp Pro Val Ile Thr Ala 
        755                 760                 765             


Ser Tyr Leu Glu Ser His His Lys Gly His Phe Ile Tyr Lys Asn Val 
    770                 775                 780                 


Ser Glu Asp Leu Pro Leu Pro Thr Phe Ser Pro Thr Leu Leu Gly Asp 
785                 790                 795                 800 


Ser Arg Met Leu Tyr Phe Trp Phe Ser Glu Arg Val Phe His Ser Leu 
                805                 810                 815     


Ala Lys Val Ala Phe Gln Asp Gly Arg Leu Met Leu Ser Leu Met Gly 
            820                 825                 830         


Asp Glu Phe Lys Ala Val Leu Glu Thr Trp Gly Phe Asn Thr Asn Gln 
        835                 840                 845             


Glu Ile Phe Gln Glu Val Val Gly Gly Phe Pro Ser Gln Ala Gln Val 
    850                 855                 860                 


Thr Val His Cys Leu Lys Met Pro Lys Ile Ser Cys Gln Asn Lys Gly 
865                 870                 875                 880 


Val Val Val Asn Ser Ser Val Met Val Lys Phe Leu Phe Pro Arg Pro 
                885                 890                 895     


Asp Gln Gln His Ser Val Ala Tyr Thr Phe Glu Glu Asp Ile Val Thr 
            900                 905                 910         


Thr Val Gln Ala Ser Tyr Ser Lys Lys Lys Leu Phe Leu Ser Leu Leu 
        915                 920                 925             


Asp Phe Gln Ile Thr Pro Lys Thr Val Ser Asn Leu Thr Glu Ser Ser 
    930                 935                 940                 


Ser Glu Ser Val Gln Ser Phe Leu Gln Ser Met Ile Thr Ala Val Gly 
945                 950                 955                 960 


Ile Pro Glu Val Met Ser Arg Leu Glu Val Val Phe Thr Ala Leu Met 
                965                 970                 975     


Asn Ser Lys Gly Val Ser Leu Phe Asp Ile Ile Asn Pro Glu Ile Ile 
            980                 985                 990         


Thr Arg Asp Gly Phe Leu Leu Leu  Gln Met Asp Phe Gly  Phe Pro Glu 
        995                 1000                 1005             


His Leu  Leu Val Asp Phe Leu  Gln Ser Leu Ser 
    1010                 1015                 


<210>  41
<211>  1068
<212>  DNA
<213>  Artificial

<220>
<223>  human PON1 Q192K DNA

<400>  41
atggcgaagc tgattgcgct caccctcttg gggatgggac tggcactctt caggaaccac       60

cagtcttctt accaaacacg acttaatgct ctccgagagg tacaacccgt agaacttcct      120

aactgtaatt tagttaaagg aatcgaaact ggctctgaag acttggagat actgcctaat      180

ggactggctt tcattagctc tggattaaag tatcctggaa taaagagctt caaccccaac      240

agtcctggaa aaatacttct gatggacctg aatgaagaag atccaacagt gttggaattg      300

gggatcactg gaagtaaatt tgatgtatct tcatttaacc ctcatgggat tagcacattc      360

acagatgaag ataatgccat gtacctcctg gtggtgaacc atccagatgc caagtccaca      420

gtggagttgt ttaaatttca agaagaagaa aaatcgcttt tgcatctaaa aaccatcaga      480

cataaacttc tgcctaattt gaatgatatt gttgctgtgg gacctgagca cttttatggc      540

acaaatgatc actattttct tgacccctac ttaaaatcct gggagatgta tttgggttta      600

gcgtggtcgt atgttgtcta ctatagtcca agtgaagttc gagtggtggc agaaggattt      660

gattttgcta atggaatcaa catttcaccc gatggcaagt atgtctatat agctgagttg      720

ctggctcata agattcatgt gtatgaaaag catgctaatt ggactttaac tccattgaag      780

tcccttgact ttaataccct cgtggataac atatctgtgg atcctgagac aggagacctt      840

tgggttggat gccatcccaa tggcatgaaa atcttcttct atgactcaga gaatcctcct      900

gcatcagagg tgcttcgaat ccagaacatt ctaacagaag aacctaaagt gacacaggtt      960

tatgcagaaa atggcacagt gttgcaaggc agtacagttg cctctgtgta caaagggaaa     1020

ctgctgattg gcacagtgtt tcacaaagct ctttactgtg agctctaa                  1068


<210>  42
<211>  355
<212>  PRT
<213>  Artificial

<220>
<223>  human PON1 Q192K polypeptide

<400>  42

Met Ala Lys Leu Ile Ala Leu Thr Leu Leu Gly Met Gly Leu Ala Leu 
1               5                   10                  15      


Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg 
            20                  25                  30          


Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile 
        35                  40                  45              


Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn 
65                  70                  75                  80  


Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe 
            100                 105                 110         


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr 
        195                 200                 205             


Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu 
        355 


<210>  43
<211>  1065
<212>  DNA
<213>  Homo sapiens

<400>  43
atggcgaagc tgattgcgct caccctcttg gggatgggac tggcactctt caggaaccac       60

cagtcttctt accaaacacg acttaatgct ctccgagagg tacaacccgt agaacttcct      120

aactgtaatt tagttaaagg aatcgaaact ggctctgaag acttggagat actgcctaat      180

ggactggctt tcattagctc tggattaaag tatcctggaa taaagagctt caaccccaac      240

agtcctggaa aaatacttct gatggacctg aatgaagaag atccaacagt gttggaattg      300

gggatcactg gaagtaaatt tgatgtatct tcatttaacc ctcatgggat tagcacattc      360

acagatgaag ataatgccat gtacctcctg gtggtgaacc atccagatgc caagtccaca      420

gtggagttgt ttaaatttca agaagaagaa aaatcgcttt tgcatctaaa aaccatcaga      480

cataaacttc tgcctaattt gaatgatatt gttgctgtgg gacctgagca cttttatggc      540

acaaatgatc actattttct tgacccctac ttaagatcct gggagatgta tttgggttta      600

gcgtggtcgt atgttgtcta ctatagtcca agtgaagttc gagtggtggc agaaggattt      660

gattttgcta atggaatcaa catttcaccc gatggcaagt atgtctatat agctgagttg      720

ctggctcata agattcatgt gtatgaaaag catgctaatt ggactttaac tccattgaag      780

tcccttgact ttaataccct cgtggataac atatctgtgg atcctgagac aggagacctt      840

tgggttggat gccatcccaa tggcatgaaa atcttcttct atgactcaga gaatcctcct      900

gcatcagagg tgcttcgaat ccagaacatt ctaacagaag aacctaaagt gacacaggtt      960

tatgcagaaa atggcacagt gttgcaaggc agtacagttg cctctgtgta caaagggaaa     1020

ctgctgattg gcacagtgtt tcacaaagct ctttactgtg agctc                     1065


<210>  44
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ala Lys Leu Ile Ala Leu Thr Leu Leu Gly Met Gly Leu Ala Leu 
1               5                   10                  15      


Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg 
            20                  25                  30          


Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile 
        35                  40                  45              


Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn 
65                  70                  75                  80  


Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe 
            100                 105                 110         


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Arg 
            180                 185                 190         


Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr 
        195                 200                 205             


Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu 
        355 


<210>  45
<211>  2677
<212>  DNA
<213>  Artificial

<220>
<223>  THER4PON1 Q192K DNA

<400>  45
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc tctccggagg aggtggctca      840

ggtggtggag gatctggagg aggtgggagt ggtggaggtg gttctaccgg tctcgagccc      900

aaatcttctg acaaaactca cacatctcca ccgtccccag cacctgaact cctgggagga      960

tcgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     1020

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg     1080

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     1140

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1200

gagtacaagt gcaaggtctc caacaaagcc ctcccagcct ccatcgagaa aaccatctcc     1260

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1320

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1380

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1440

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1500

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1560

cagaagagcc tctctctctc tccgggtaaa gtcgacggag ctagcagccc cgtgaacgtg     1620

agcagcccca gcgtgcagga tatcctcttc aggaaccacc agtcttctta ccaaacacga     1680

cttaatgctc tccgagaggt acaacccgta gaacttccta actgtaattt agttaaagga     1740

atcgaaactg gctctgaaga cttggagata ctgcctaatg gactggcttt cattagctct     1800

ggattaaagt atcctggaat aaagagcttc aaccccaaca gtcctggaaa aatacttctg     1860

atggacctga atgaagaaga tccaacagtg ttggaattgg ggatcactgg aagtaaattt     1920

gatgtatctt catttaaccc tcatgggatt agcacattca cagatgaaga taatgccatg     1980

tacctcctgg tggtgaacca tccagatgcc aagtccacag tggagttgtt taaatttcaa     2040

gaagaagaaa aatcgctttt gcatctaaaa accatcagac ataaacttct gcctaatttg     2100

aatgatattg ttgctgtggg acctgagcac ttttatggca caaatgatca ctattttctt     2160

gacccctact taaaatcctg ggagatgtat ttgggtttag cgtggtcgta tgttgtctac     2220

tatagtccaa gtgaagttcg agtggtggca gaaggatttg attttgctaa tggaatcaac     2280

atttcacccg atggcaagta tgtctatata gctgagttgc tggctcataa gattcatgtg     2340

tatgaaaagc atgctaattg gactttaact ccattgaagt cccttgactt taataccctc     2400

gtggataaca tatctgtgga tcctgagaca ggagaccttt gggttggatg ccatcccaat     2460

ggcatgaaaa tcttcttcta tgactcagag aatcctcctg catcagaggt gcttcgaatc     2520

cagaacattc taacagaaga acctaaagtg acacaggttt atgcagaaaa tggcacagtg     2580

ttgcaaggca gtacagttgc ctctgtgtac aaagggaaac tgctgattgg cacagtgttt     2640

cacaaagctc tttactgtga gctctaataa tctagaa                              2677


<210>  46
<211>  883
<212>  PRT
<213>  Artificial

<220>
<223>  THER4PON1 Q192K polypeptide

<400>  46

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 
    290                 295                 300                 


Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu 
305                 310                 315                 320 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                325                 330                 335     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            340                 345                 350         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        355                 360                 365             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    370                 375                 380                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
385                 390                 395                 400 


Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys 
                405                 410                 415     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            420                 425                 430         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        435                 440                 445             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    450                 455                 460                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
465                 470                 475                 480 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                485                 490                 495     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            500                 505                 510         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly 
        515                 520                 525             


Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Leu 
    530                 535                 540                 


Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg 
545                 550                 555                 560 


Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile 
                565                 570                 575     


Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
            580                 585                 590         


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn 
        595                 600                 605             


Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr 
    610                 615                 620                 


Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe 
625                 630                 635                 640 


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr 
                645                 650                 655     


Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe 
            660                 665                 670         


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
        675                 680                 685             


His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu 
    690                 695                 700                 


His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Lys 
705                 710                 715                 720 


Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr 
                725                 730                 735     


Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
            740                 745                 750         


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
        755                 760                 765             


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
    770                 775                 780                 


Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser 
785                 790                 795                 800 


Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
                805                 810                 815     


Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val 
            820                 825                 830         


Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val 
        835                 840                 845             


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val 
    850                 855                 860                 


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
865                 870                 875                 880 


Cys Glu Leu 
            


<210>  47
<211>  2677
<212>  DNA
<213>  Artificial

<220>
<223>  THER4PON1 Q192R DNA

<400>  47
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc tctccggagg aggtggctca      840

ggtggtggag gatctggagg aggtgggagt ggtggaggtg gttctaccgg tctcgagccc      900

aaatcttctg acaaaactca cacatctcca ccgtccccag cacctgaact cctgggagga      960

tcgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     1020

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg     1080

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     1140

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1200

gagtacaagt gcaaggtctc caacaaagcc ctcccagcct ccatcgagaa aaccatctcc     1260

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1320

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1380

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1440

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1500

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1560

cagaagagcc tctctctctc tccgggtaaa gtcgacggag ctagcagccc cgtgaacgtg     1620

agcagcccca gcgtgcagga tatcctcttc aggaaccacc agtcttctta ccaaacacga     1680

cttaatgctc tccgagaggt acaacccgta gaacttccta actgtaattt agttaaagga     1740

atcgaaactg gctctgaaga cttggagata ctgcctaatg gactggcttt cattagctct     1800

ggattaaagt atcctggaat aaagagcttc aaccccaaca gtcctggaaa aatacttctg     1860

atggacctga atgaagaaga tccaacagtg ttggaattgg ggatcactgg aagtaaattt     1920

gatgtatctt catttaaccc tcatgggatt agcacattca cagatgaaga taatgccatg     1980

tacctcctgg tggtgaacca tccagatgcc aagtccacag tggagttgtt taaatttcaa     2040

gaagaagaaa aatcgctttt gcatctaaaa accatcagac ataaacttct gcctaatttg     2100

aatgatattg ttgctgtggg acctgagcac ttttatggca caaatgatca ctattttctt     2160

gacccctact taagatcctg ggagatgtat ttgggtttag cgtggtcgta tgttgtctac     2220

tatagtccaa gtgaagttcg agtggtggca gaaggatttg attttgctaa tggaatcaac     2280

atttcacccg atggcaagta tgtctatata gctgagttgc tggctcataa gattcatgtg     2340

tatgaaaagc atgctaattg gactttaact ccattgaagt cccttgactt taataccctc     2400

gtggataaca tatctgtgga tcctgagaca ggagaccttt gggttggatg ccatcccaat     2460

ggcatgaaaa tcttcttcta tgactcagag aatcctcctg catcagaggt gcttcgaatc     2520

cagaacattc taacagaaga acctaaagtg acacaggttt atgcagaaaa tggcacagtg     2580

ttgcaaggca gtacagttgc ctctgtgtac aaagggaaac tgctgattgg cacagtgttt     2640

cacaaagctc tttactgtga gctctaataa tctagaa                              2677


<210>  48
<211>  883
<212>  PRT
<213>  Artificial

<220>
<223>  THER4PON1 Q192R polypeptide

<400>  48

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 
    290                 295                 300                 


Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu 
305                 310                 315                 320 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                325                 330                 335     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            340                 345                 350         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        355                 360                 365             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    370                 375                 380                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
385                 390                 395                 400 


Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys 
                405                 410                 415     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            420                 425                 430         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        435                 440                 445             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    450                 455                 460                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
465                 470                 475                 480 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                485                 490                 495     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            500                 505                 510         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly 
        515                 520                 525             


Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Leu 
    530                 535                 540                 


Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg 
545                 550                 555                 560 


Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile 
                565                 570                 575     


Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
            580                 585                 590         


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn 
        595                 600                 605             


Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr 
    610                 615                 620                 


Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe 
625                 630                 635                 640 


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr 
                645                 650                 655     


Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe 
            660                 665                 670         


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
        675                 680                 685             


His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu 
    690                 695                 700                 


His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Arg 
705                 710                 715                 720 


Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr 
                725                 730                 735     


Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
            740                 745                 750         


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
        755                 760                 765             


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
    770                 775                 780                 


Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser 
785                 790                 795                 800 


Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
                805                 810                 815     


Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val 
            820                 825                 830         


Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val 
        835                 840                 845             


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val 
    850                 855                 860                 


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
865                 870                 875                 880 


Cys Glu Leu 
            


<210>  49
<211>  82
<212>  DNA
<213>  Artificial

<220>
<223>  (gly4ser)4 linker DNA

<400>  49
agatctctcc ggaggaggtg gctcaggtgg tggaggatct ggaggaggtg ggagtggtgg       60

aggtggttct accggtctcg ag                                                82


<210>  50
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  (gly4ser)4 linker

<400>  50

Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu 
            20                  25      


<210>  51
<211>  112
<212>  DNA
<213>  Artificial

<220>
<223>  (gly4ser)6 linker DNA

<400>  51
agatctctcc ggaggaggtg gctcaggtgg tggaggatct ggaggaggtg ggagtggtgg       60

aggtggttct ggaggaggtg gtagtggagg tggaggttct accggtctcg ag              112


<210>  52
<211>  36
<212>  PRT
<213>  Artificial

<220>
<223>  (gly4ser)6 linker

<400>  52

Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Thr Gly Leu 
        35      


<210>  53
<211>  93
<212>  DNA
<213>  Artificial

<220>
<223>  (gly4ser)5 linker DNA

<400>  53
gatctctccg gaggaggtgg ctcaggtggt ggaggatctg gaggaggtgg gagtggtgga       60

ggtggttctg gaggaggtgg tagtaccggt ctc                                    93


<210>  54
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  (gly4ser)5 linker

<400>  54

Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu 
            20                  25                  30      


