                         SEQUENCE LISTING

<110>  MacManus, Chris
 
<120>  LACTOFERRIN COMPOSITIONS AND METHODS FOR MODULATION OF T CELL 
       SUBTYPES  AND TREATMENT OF AUTOIMMUNE DISEASES

<130>  VBI-8041.US00

<150>  US 62/217,782
<151>  2015-09-11

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  2648
<212>  DNA
<213>  Homo sapiens

<400>  1
gactcctagg ggcttgcaga ctagtgggag agaaagaaca tcgcagcagc caggcagaac       60

caggacaggt gaggtgcagg ctggctttcc tctcgcagcg cggtgtggag tcctgtcctg      120

cctcagggct tttcggagcc tggatcctca aggaacaagt agacctggcc gcggggagtg      180

gggagggaag gggtgtctat tgggcaacag ggcggggcaa agccctgaat aaaggggcgc      240

agggcaggcg caagtggcag agccttcgtt tgccaagtcg cctccagacc gcagacatga      300

aacttgtctt cctcgtcctg ctgttcctcg gggccctcgg actgtgtctg gctggccgta      360

ggaggagtgt tcagtggtgc gccgtatccc aacccgaggc cacaaaatgc ttccaatggc      420

aaaggaatat gagaaaagtg cgtggccctc ctgtcagctg cataaagaga gactccccca      480

tccagtgtat ccaggccatt gcggaaaaca gggccgatgc tgtgaccctt gatggtggtt      540

tcatatacga ggcaggcctg gccccctaca aactgcgacc tgtagcggcg gaagtctacg      600

ggaccgaaag acagccacga actcactatt atgccgtggc tgtggtgaag aagggcggca      660

gctttcagct gaacgaactg caaggtctga agtcctgcca cacaggcctt cgcaggaccg      720

ctggatggaa tgtccctata gggacacttc gtccattctt gaattggacg ggtccacctg      780

agcccattga ggcagctgtg gccaggttct tctcagccag ctgtgttccc ggtgcagata      840

aaggacagtt ccccaacctg tgtcgcctgt gtgcggggac aggggaaaac aaatgtgcct      900

tctcctccca ggaaccgtac ttcagctact ctggtgcctt caagtgtctg agagacgggg      960

ctggagacgt ggcttttatc agagagagca cagtgtttga ggacctgtca gacgaggctg     1020

aaagggacga gtatgagtta ctctgcccag acaacactcg gaagccagtg gacaagttca     1080

aagactgcca tctggcccgg gtcccttctc atgccgttgt ggcacgaagt gtgaatggca     1140

aggaggatgc catctggaat cttctccgcc aggcacagga aaagtttgga aaggacaagt     1200

caccgaaatt ccagctcttt ggctccccta gtgggcagaa agatctgctg ttcaaggact     1260

ctgccattgg gttttcgagg gtgcccccga ggatagattc tgggctgtac cttggctccg     1320

gctacttcac tgccatccag aacttgagga aaagtgagga ggaagtggct gcccggcgtg     1380

cgcgggtcgt gtggtgtgcg gtgggcgagc aggagctgcg caagtgtaac cagtggagtg     1440

gcttgagcga aggcagcgtg acctgctcct cggcctccac cacagaggac tgcatcgccc     1500

tggtgctgaa aggagaagct gatgccatga gtttggatgg aggatatgtg tacactgcag     1560

gcaaatgtgg tttggtgcct gtcctggcag agaactacaa atcccaacaa agcagtgacc     1620

ctgatcctaa ctgtgtggat agacctgtgg aaggatatct tgctgtggcg gtggttagga     1680

gatcagacac tagccttacc tggaactctg tgaaaggcaa gaagtcctgc cacaccgccg     1740

tggacaggac tgcaggctgg aatatcccca tgggcctgct cttcaaccag acgggctcct     1800

gcaaatttga tgaatatttc agtcaaagct gtgcccctgg gtctgacccg agatctaatc     1860

tctgtgctct gtgtattggc gacgagcagg gtgagaataa gtgcgtgccc aacagcaacg     1920

agagatacta cggctacact ggggctttcc ggtgcctggc tgagaatgct ggagacgttg     1980

catttgtgaa agatgtcact gtcttgcaga acactgatgg aaataacaat gaggcatggg     2040

ctaaggattt gaagctggca gactttgcgc tgctgtgcct cgatggcaaa cggaagcctg     2100

tgactgaggc tagaagctgc catcttgcca tggccccgaa tcatgccgtg gtgtctcgga     2160

tggataaggt ggaacgcctg aaacaggtgt tgctccacca acaggctaaa tttgggagaa     2220

atggatctga ctgcccggac aagttttgct tattccagtc tgaaaccaaa aaccttctgt     2280

tcaatgacaa cactgagtgt ctggccagac tccatggcaa aacaacatat gaaaaatatt     2340

tgggaccaca gtatgtcgca ggcattacta atctgaaaaa gtgctcaacc tcccccctcc     2400

tggaagcctg tgaattcctc aggaagtaaa accgaagaag atggcccagc tccccaagaa     2460

agcctcagcc attcactgcc cccagctctt ctccccaggt gtgttggggc cttggcctcc     2520

cctgctgaag gtggggattg cccatccatc tgcttacaat tccctgctgt cgtcttagca     2580

agaagtaaaa tgagaaattt tgttgatatt ctctccttaa aaaaaaaaaa aaaaaaaaaa     2640

aaaaaaaa                                                              2648


<210>  2
<211>  692
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Arg Arg Arg Arg Ser Val Gln Trp Cys Ala Val Ser Gln Pro Glu 
1               5                   10                  15      


Ala Thr Lys Cys Phe Gln Trp Gln Arg Asn Met Arg Lys Val Arg Gly 
            20                  25                  30          


Pro Pro Val Ser Cys Ile Lys Arg Asp Ser Pro Ile Gln Cys Ile Gln 
        35                  40                  45              


Ala Ile Ala Glu Asn Arg Ala Asp Ala Val Thr Leu Asp Gly Gly Phe 
    50                  55                  60                  


Ile Tyr Glu Ala Gly Leu Ala Pro Tyr Lys Leu Arg Pro Val Ala Ala 
65                  70                  75                  80  


Glu Val Tyr Gly Thr Glu Arg Gln Pro Arg Thr His Tyr Tyr Ala Val 
                85                  90                  95      


Ala Val Val Lys Lys Gly Gly Ser Phe Gln Leu Asn Glu Leu Gln Gly 
            100                 105                 110         


Leu Lys Ser Cys His Thr Gly Leu Arg Arg Thr Ala Gly Trp Asn Val 
        115                 120                 125             


Pro Ile Gly Thr Leu Arg Pro Phe Leu Asn Trp Thr Gly Pro Pro Glu 
    130                 135                 140                 


Pro Ile Glu Ala Ala Val Ala Arg Phe Phe Ser Ala Ser Cys Val Pro 
145                 150                 155                 160 


Gly Ala Asp Lys Gly Gln Phe Pro Asn Leu Cys Arg Leu Cys Ala Gly 
                165                 170                 175     


Thr Gly Glu Asn Lys Cys Ala Phe Ser Ser Gln Glu Pro Tyr Phe Ser 
            180                 185                 190         


Tyr Ser Gly Ala Phe Lys Cys Leu Arg Asp Gly Ala Gly Asp Val Ala 
        195                 200                 205             


Phe Ile Arg Glu Ser Thr Val Phe Glu Asp Leu Ser Asp Glu Ala Glu 
    210                 215                 220                 


Arg Asp Glu Tyr Glu Leu Leu Cys Pro Asp Asn Thr Arg Lys Pro Val 
225                 230                 235                 240 


Asp Lys Phe Lys Asp Cys His Leu Ala Arg Val Pro Ser His Ala Val 
                245                 250                 255     


Val Ala Arg Ser Val Asn Gly Lys Glu Asp Ala Ile Trp Asn Leu Leu 
            260                 265                 270         


Arg Gln Ala Gln Glu Lys Phe Gly Lys Asp Lys Ser Pro Lys Phe Gln 
        275                 280                 285             


Leu Phe Gly Ser Pro Ser Gly Gln Lys Asp Leu Leu Phe Lys Asp Ser 
    290                 295                 300                 


Ala Ile Gly Phe Ser Arg Val Pro Pro Arg Ile Asp Ser Gly Leu Tyr 
305                 310                 315                 320 


Leu Gly Ser Gly Tyr Phe Thr Ala Ile Gln Asn Leu Arg Lys Ser Glu 
                325                 330                 335     


Glu Glu Val Ala Ala Arg Arg Ala Arg Val Val Trp Cys Ala Val Gly 
            340                 345                 350         


Glu Gln Glu Leu Arg Lys Cys Asn Gln Trp Ser Gly Leu Ser Glu Gly 
        355                 360                 365             


Ser Val Thr Cys Ser Ser Ala Ser Thr Thr Glu Asp Cys Ile Ala Leu 
    370                 375                 380                 


Val Leu Lys Gly Glu Ala Asp Ala Met Ser Leu Asp Gly Gly Tyr Val 
385                 390                 395                 400 


Tyr Thr Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu Asn Tyr 
                405                 410                 415     


Lys Ser Gln Gln Ser Ser Asp Pro Asp Pro Asn Cys Val Asp Arg Pro 
            420                 425                 430         


Val Glu Gly Tyr Leu Ala Val Ala Val Val Arg Arg Ser Asp Thr Ser 
        435                 440                 445             


Leu Thr Trp Asn Ser Val Lys Gly Lys Lys Ser Cys His Thr Ala Val 
    450                 455                 460                 


Asp Arg Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Leu Phe Asn Gln 
465                 470                 475                 480 


Thr Gly Ser Cys Lys Phe Asp Glu Tyr Phe Ser Gln Ser Cys Ala Pro 
                485                 490                 495     


Gly Ser Asp Pro Arg Ser Asn Leu Cys Ala Leu Cys Ile Gly Asp Glu 
            500                 505                 510         


Gln Gly Glu Asn Lys Cys Val Pro Asn Ser Asn Glu Arg Tyr Tyr Gly 
        515                 520                 525             


Tyr Thr Gly Ala Phe Arg Cys Leu Ala Glu Asn Ala Gly Asp Val Ala 
    530                 535                 540                 


Phe Val Lys Asp Val Thr Val Leu Gln Asn Thr Asp Gly Asn Asn Asn 
545                 550                 555                 560 


Glu Ala Trp Ala Lys Asp Leu Lys Leu Ala Asp Phe Ala Leu Leu Cys 
                565                 570                 575     


Leu Asp Gly Lys Arg Lys Pro Val Thr Glu Ala Arg Ser Cys His Leu 
            580                 585                 590         


Ala Met Ala Pro Asn His Ala Val Val Ser Arg Met Asp Lys Val Glu 
        595                 600                 605             


Arg Leu Lys Gln Val Leu Leu His Gln Gln Ala Lys Phe Gly Arg Asn 
    610                 615                 620                 


Gly Ser Asp Cys Pro Asp Lys Phe Cys Leu Phe Gln Ser Glu Thr Lys 
625                 630                 635                 640 


Asn Leu Leu Phe Asn Asp Asn Thr Glu Cys Leu Ala Arg Leu His Gly 
                645                 650                 655     


Lys Thr Thr Tyr Glu Lys Tyr Leu Gly Pro Gln Tyr Val Ala Gly Ile 
            660                 665                 670         


Thr Asn Leu Lys Lys Cys Ser Thr Ser Pro Leu Leu Glu Ala Cys Glu 
        675                 680                 685             


Phe Leu Arg Lys 
    690         


<210>  3
<211>  2076
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant sequence generated in laboratory

<400>  3
gggcggcggc ggcgctcggt gcagtggtgc gccgtgtccc agcccgaggc gaccaagtgc       60

ttccagtggc agcgcaacat gcggaaggtg cgcggcccgc cggtcagctg catcaagcgg      120

gactccccca tccaatgcat ccaggccatc gcggagaacc gcgccgacgc ggtcaccctg      180

gacggcgggt tcatctacga ggcggggctc gccccgtaca agctccgccc ggtggcggcg      240

gaggtgtacg gcaccgagcg ccagccgcgc acgcactact acgcggtggc cgtcgtcaag      300

aagggcgggt ccttccagct caacgagctg cagggcctga agtcgtgcca cacgggcctc      360

cggcggacgg cgggctggaa cgtgcccatc ggcaccctgc gccccttcct gaactggacc      420

ggcccgccgg agccgatcga ggccgccgtg gcccgcttct tcagcgcctc ctgcgtcccc      480

ggcgccgaca agggccagtt cccgaacctc tgccggctct gcgccgggac gggcgagaac      540

aagtgcgcct tctcctcgca ggagccgtac ttctcctact cgggcgcgtt caagtgcctc      600

cgcgacgggg ccggcgacgt ggcgttcatc cgcgagtcca ccgtgttcga ggacctctcc      660

gacgaggcgg agcgggacga gtacgagctg ctgtgccccg acaacacccg caagccggtg      720

gacaagttca aggactgcca cctggcgcgg gtgccctcgc acgcggtcgt cgcccgcagc      780

gtcaacggca aggaggacgc gatctggaac ctcctccgcc aggcccagga gaagttcggc      840

aaggacaagt cccccaagtt ccagctcttc gggagcccca gcggccagaa ggacctcctc      900

ttcaaggact ccgcgatcgg cttctcccgc gtccccccgc gcatcgactc cggcctgtac      960

ctcggctccg ggtacttcac cgcgatccag aacctccgga agagcgagga ggaggtggcg     1020

gcgcggcggg cccgcgtcgt gtggtgcgcc gtgggcgagc aggagctgcg gaagtgcaac     1080

cagtggagcg gcctgagcga ggggtcggtg acctgctcgt ccgccagcac caccgaggac     1140

tgcatcgcgc tcgtcctcaa gggggaggcc gacgcgatga gcctcgacgg ggggtacgtc     1200

tacaccgccg gcaagtgcgg cctggtcccg gtcctggcgg agaactacaa gtcgcagcag     1260

tccagcgacc ccgacccgaa ctgcgtggac cgccccgtcg agggctacct cgccgtggcc     1320

gtcgtgcgcc ggtccgacac ctccctgacg tggaacagcg tcaagggcaa gaagagctgc     1380

cacaccgccg tggaccgcac cgccggctgg aacatcccga tgggcctcct cttcaaccag     1440

accggctcct gcaagttcga cgagtacttc tcccagtcct gcgcccccgg ctcggacccc     1500

cgctccaacc tgtgcgccct ctgcatcggg gacgagcagg gcgagaacaa gtgcgtgccc     1560

aacagcaacg agcggtacta cggctacacg ggggccttcc gctgcctggc ggagaacgcc     1620

ggggacgtcg cgttcgtgaa ggacgtgacc gtgctgcaaa acacggacgg gaacaacaac     1680

gaggcgtggg cgaaggacct caagctcgcc gacttcgccc tgctgtgcct cgacggcaag     1740

cgcaagcccg tcaccgaggc gcggtcctgc cacctggcga tggcccccaa ccacgccgtc     1800

gtctcccgca tggacaaggt cgagcgcctc aagcaggtgc tcctgcacca gcaggccaag     1860

ttcggccgga acggcagcga ctgcccggac aagttctgcc tgttccagtc ggagaccaag     1920

aacctcctct tcaacgacaa caccgagtgc ctggcgcgcc tccacggcaa gaccacctac     1980

gagaagtacc tcggcccgca gtacgtcgcc ggcatcacca acctcaagaa gtgctccacc     2040

tcccccctcc tggaggcgtg cgagttcctc cgcaag                               2076


<210>  4
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant sequence generated in laboratory

<400>  4

Gly Arg Arg Arg Arg Ser Val Gln Trp Cys Ala Val Ser Gln Pro Glu 
1               5                   10                  15      


Ala Thr Lys Cys Phe Gln Trp Gln Arg Asn Met Arg Lys Val Arg Gly 
            20                  25                  30          


Pro Pro Val Ser Cys Ile Lys Arg Asp Ser Pro Ile Gln Cys Ile Gln 
        35                  40                  45              


Ala Ile Ala Glu Asn Arg Ala Asp Ala Val Thr Leu Asp Gly Gly Phe 
    50                  55                  60                  


Ile Tyr Glu Ala Gly Leu Ala Pro Tyr Lys Leu Arg Pro Val Ala Ala 
65                  70                  75                  80  


Glu Val Tyr Gly Thr Glu Arg Gln Pro Arg Thr His Tyr Tyr Ala Val 
                85                  90                  95      


Ala Val Val Lys Lys Gly Gly Ser Phe Gln Leu Asn Glu Leu Gln Gly 
            100                 105                 110         


Leu Lys Ser Cys His Thr Gly Leu Arg Arg Thr Ala Gly Trp Asn Val 
        115                 120                 125             


Pro Ile Gly Thr Leu Arg Pro Phe Leu Asn Trp Thr Gly Pro Pro Glu 
    130                 135                 140                 


Pro Ile Glu Ala Ala Val Ala Arg Phe Phe Ser Ala Ser Cys Val Pro 
145                 150                 155                 160 


Gly Ala Asp Lys Gly Gln Phe Pro Asn Leu Cys Arg Leu Cys Ala Gly 
                165                 170                 175     


Thr Gly Glu Asn Lys Cys Ala Phe Ser Ser Gln Glu Pro Tyr Phe Ser 
            180                 185                 190         


Tyr Ser Gly Ala Phe Lys Cys Leu Arg Asp Gly Ala Gly Asp Val Ala 
        195                 200                 205             


Phe Ile Arg Glu Ser Thr Val Phe Glu Asp Leu Ser Asp Glu Ala Glu 
    210                 215                 220                 


Arg Asp Glu Tyr Glu Leu Leu Cys Pro Asp Asn Thr Arg Lys Pro Val 
225                 230                 235                 240 


Asp Lys Phe Lys Asp Cys His Leu Ala Arg Val Pro Ser His Ala Val 
                245                 250                 255     


Val Ala Arg Ser Val Asn Gly Lys Glu Asp Ala Ile Trp Asn Leu Leu 
            260                 265                 270         


Arg Gln Ala Gln Glu Lys Phe Gly Lys Asp Lys Ser Pro Lys Phe Gln 
        275                 280                 285             


Leu Phe Gly Ser Pro Ser Gly Gln Lys Asp Leu Leu Phe Lys Asp Ser 
    290                 295                 300                 


Ala Ile Gly Phe Ser Arg Val Pro Pro Arg Ile Asp Ser Gly Leu Tyr 
305                 310                 315                 320 


Leu Gly Ser Gly Tyr Phe Thr Ala Ile Gln Asn Leu Arg Lys Ser Glu 
                325                 330                 335     


Glu Glu Val Ala Ala Arg Arg Ala Arg Val Val Trp Cys Ala Val Gly 
            340                 345                 350         


Glu Gln Glu Leu Arg Lys Cys Asn Gln Trp Ser Gly Leu Ser Glu Gly 
        355                 360                 365             


Ser Val Thr Cys Ser Ser Ala Ser Thr Thr Glu Asp Cys Ile Ala Leu 
    370                 375                 380                 


Val Leu Lys Gly Glu Ala Asp Ala Met Ser Leu Asp Gly Gly Tyr Val 
385                 390                 395                 400 


Tyr Thr Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu Asn Tyr 
                405                 410                 415     


Lys Ser Gln Gln Ser Ser Asp Pro Asp Pro Asn Cys Val Asp Arg Pro 
            420                 425                 430         


Val Glu Gly Tyr Leu Ala Val Ala Val Val Arg Arg Ser Asp Thr Ser 
        435                 440                 445             


Leu Thr Trp Asn Ser Val Lys Gly Lys Lys Ser Cys His Thr Ala Val 
    450                 455                 460                 


Asp Arg Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Leu Phe Asn Gln 
465                 470                 475                 480 


Thr Gly Ser Cys Lys Phe Asp Glu Tyr Phe Ser Gln Ser Cys Ala Pro 
                485                 490                 495     


Gly Ser Asp Pro Arg Ser Asn Leu Cys Ala Leu Cys Ile Gly Asp Glu 
            500                 505                 510         


Gln Gly Glu Asn Lys Cys Val Pro Asn Ser Asn Glu Arg Tyr Tyr Gly 
        515                 520                 525             


Tyr Thr Gly Ala Phe Arg Cys Leu Ala Glu Asn Ala Gly Asp Val Ala 
    530                 535                 540                 


Phe Val Lys Asp Val Thr Val Leu Gln Asn Thr Asp Gly Asn Asn Asn 
545                 550                 555                 560 


Glu Ala Trp Ala Lys Asp Leu Lys Leu Ala Asp Phe Ala Leu Leu Cys 
                565                 570                 575     


Leu Asp Gly Lys Arg Lys Pro Val Thr Glu Ala Arg Ser Cys His Leu 
            580                 585                 590         


Ala Met Ala Pro Asn His Ala Val Val Ser Arg Met Asp Lys Val Glu 
        595                 600                 605             


Arg Leu Lys Gln Val Leu Leu His Gln Gln Ala Lys Phe Gly Arg Asn 
    610                 615                 620                 


Gly Ser Asp Cys Pro Asp Lys Phe Cys Leu Phe Gln Ser Glu Thr Lys 
625                 630                 635                 640 


Asn Leu Leu Phe Asn Asp Asn Thr Glu Cys Leu Ala Arg Leu His Gly 
                645                 650                 655     


Lys Thr Thr Tyr Glu Lys Tyr Leu Gly Pro Gln Tyr Val Ala Gly Ile 
            660                 665                 670         


Thr Asn Leu Lys Lys Cys Ser Thr Ser Pro Leu Leu Glu Ala Cys Glu 
        675                 680                 685             


Phe Leu Arg Lys 
    690         


<210>  5
<211>  14647
<212>  DNA
<213>  Bos taurus


<220>
<221>  misc_feature
<222>  (1123)..(1222)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1498)..(1597)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (5349)..(5448)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (7480)..(7579)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (9184)..(9283)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (10656)..(10755)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (12194)..(12293)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (12987)..(13086)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (13696)..(13795)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (14137)..(14236)
<223>  n is a, c, g, or t

<400>  5
gatcttagtt cccccaaatg ggtctgaacc tacacatgct gcaatggaag cgccagggaa       60

gtcctccccc accccttggg ggacacttag tttgcttgca atcagtgaac gataagcagg      120

gctgcactgg agacccctgc gtgggagttg ttgtgcttca agggagtgtc ttcaaggatg      180

cagagcagag ttctagctta gaactgaaaa ccagcctcct gaaacagggt cagcctgtgt      240

actgaggaca aaataggaca tttatcaaaa tgaggttcct gtctcccacc tcatattgcc      300

acaaaacaac acaaggggta ggatatcctt ttcattggca aatgagggac caggagacag      360

cctttgggca cttaggcctc tggttctgtt ttctgggagc tgtatttcgg tctcaggagg      420

actccagggg cagtctgggt cagactctgg gcagcctctg ccagctggac caggctgccg      480

tggaccccgg gccaggcagc gggccctctt tcaaaactcc aggctggctc tgcgtgcaga      540

tgcaagggtc tccgtctgtc ttaactggtt cccaagcact ttagatacct tctctatagt      600

caagctgatc cgcaaagatt caccctagga cccctgctct ggatcccgct ctctaggagg      660

cactgagacc ggagcgggga caaaacccag ggactgccac tcccgaaggg ctgcggacaa      720

gtgggaaaga aagagcaccc cccaactagg cagcgctggg gaacttgaga ggtgggtgtg      780

ggttgggtat cctctccccg agcgccaagc cccgcccggg cacctttctc gctccctcgg      840

tctccacccc cgctcttccc ccttcccccc ggttttcccc ctctaggaac cagcagacct      900

cgggagaggg gaggagggag gctggggcgc ttataggacc acagggcggg gcaaacctcg      960

tgaggtcacc gagcactggc taaagggacg cagaacgagc gcaggtggca gagccttcgt     1020

tccggagtcg ccccaggacg ccagccatga agctcttcgt ccccgccctg ctgtccctcg     1080

gagcccttgg tgagtgcagg tatgagtggg ggcggggcat gcnnnnnnnn nnnnnnnnnn     1140

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1200

nnnnnnnnnn nnnnnnnnnn nncaagaccg tctcttccag ggacagtgta gaagccctca     1260

ctctttggcc tctttactcc caggactgtg tctggctgcc ccgaggaaaa acgttcgatg     1320

gtgtaccatc tcccaacccg agtggttcaa atgccgccga tggcagtgga ggatgaagaa     1380

gctgggtgct ccctctatca cctgtgtgag gagggccttt gccttggcat gtatccgggc     1440

catcgcggtg agtccaggcc gtaggctggg tgggaccaga ctgaaaggga agggatcnnn     1500

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1560

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnagt cactgcctgg cataggtagt     1620

ttctcctgaa gctggtctgg cctgtgtttc agagaaaaag gcggatgctg tgaccctgga     1680

tggtggcatg gtgtttgagg cgggccggga cccctacaaa ctgcggccag tagcagcaga     1740

gatctatggg acgaaagagt gtgagttctc cctggggacc cagaagttga ggtggcctgg     1800

acctgggccc tgggctctgt ggggtcagag tggacaaggc acagagctga ggtctcagac     1860

agtgtcacat gtccagggaa tgatgtccct gggctctttg ggccagtcac caacccactg     1920

gggaagcaga ggaggcgctg ggctgcagtg accagagaat tcccctccca ctaggggctc     1980

attcagggag ggctgtttct ctctctctct ggttcacgct aagagctctc tattgtctct     2040

gcctcttctg cagctcccca aacccactat tatgctgtgg ccgtcgtgaa gaagggcagc     2100

aactttcagc tggaccagct gcaaggccgg aagtcctgcc atacgggcct tggcaggtcc     2160

gctgggtggg tcatccctat gggaatcctt cgcccgtact tgagctggac agagtcactc     2220

gagcccctcc agggaggtaa gacacgtcgg ggttctggtg atcccaggct ggggtctcta     2280

ctccggtgtc actttcacaa gccacttcgg ggtgtcccag gtgagcatgt ggggtgaatc     2340

caaggcaggg gtcaggttaa ctgctgtgaa gcctgtgggg atggggtctt ctgtatcagg     2400

agccctggga gttggtagct gagtctgctg ctgctgctaa gtcgcttcag tcatgtccga     2460

ctctgtgcga cccatagatg gtgaatccct accagcctcc ctcaattcat ggggattttc     2520

cagccaagag tacttggagt gggggggccg ttcccttctc caggtagctg agtctagttt     2580

cagccactgt acatcttctg agctcctggc tttccaaagg ctatcaggtg ggggtggagg     2640

ggagggaaca ctgggggtgc cactggctgt ggtctggtga gctcacaccc tggtttattt     2700

ctctctgttc aacagctgtg gctaaattct tctctgccag ctgtgttccc tgcattgata     2760

gacaagcata ccccaacctg tgtcaactgt gcaaggggga gggggagaac cagtgtgcct     2820

gctcctcccg ggaaccatac ttcggttatt ctggtgcctt caagtgtaag gtgagactgt     2880

cctcttctcc ccagcggccc atgtgtcctt gggctaggag gtccctttct ctgggcccaa     2940

atagagctca gtgagcatgt ggggaccatg gaggaggtcc agttctcctg tgcagagaaa     3000

ctgagtatga aaaatgtgcg ggctctgtcc agtgcacgat ctcctccagt cccctagccc     3060

cccgcagggc cccctcacct ctgcaccagc ccagcaaaca gttacctcgt cagcgtcccc     3120

tcatgtctcc ccagagatcc ctgaatctgg ctttgtccct ctgcggtcct gggctcctcc     3180

tgctgacagg tgtcccctcc ctaactacag agggactgaa ggagtcttgt catgagcaga     3240

ccagccccag acccctggcc aggcagtcgg acagcctggt ccctctccct gggaggtagt     3300

gatctctgct cactggggag ctctctcctt cgccccagcc tcgcactgaa gctgatgttt     3360

ctccttttac cccatctgtc tctcggactc aggcattttg tgtgtggggg ggaggcctcc     3420

ccgattctct gctgctcagg gcacgtttac cacttagccc tgggagggga aaaaaccacg     3480

tggccgcatg tactgctttt accctctggt gcagaggctt ggaaactctt ttacagagaa     3540

agacaaagtt ttgccctctc aatcaaccct taaaggggaa agtggggggt ctctagccag     3600

catcctctgg ttctttcttc ctcagaatcc atctgcaggt ggatctattc cctccatggg     3660

ggccccagag cctcagagac ctgtcctctg caggtcagga gcccacagaa gacaagcccc     3720

agggcccctt tccacaggca ggctcgagga acaagccggg ctggctgctc tgtgctgacc     3780

cttctggtgc tttctcatcc cacaggtgtc tgcaggacgg ggctggagac gtggcttttg     3840

ttaaagagac gacagtgttt ggtaagtgga ggagagaagc cacgggtact gcctcctttg     3900

ctttgctttc ctttcatttc attgtaaatc caagtagtga gctaatttga ctcctcactt     3960

cctggcacac gattatcaaa gctctctgta gagcacagct cttattttta tgtgacttta     4020

tattttaagc aatcagtttt ctttgaaact cccgtgcccg ctatctttct cttctgcatc     4080

aaagacgccc atgtcaaggt atctgacaca tgtcctccga gacagatgta gtcttgcaaa     4140

gtgtatgggg ctgatctgtg tttctggatt ctaagctcac agaaagtttt attgatccgt     4200

tattgatgat gagtggatca agtttcccgc tcagcatcct gttttagaga tttagtgttg     4260

ttgtgctgta catgtctggt tcagtggttc taacactgag acgtgctctg tggagagcac     4320

acaacacatt tattatccac ggtcgtaaag cggtagatac gtcagtgtgg tttatcttgc     4380

atttctctgg catctggtga gtttgatcat ctcagtatat ttgctggtag tttgggcttc     4440

cctttcttcc tttttcacct ttgactatct ttctattgat tttcatgcct gtttcttcat     4500

gattttgatt caagctgagg cattcctcct ctctaggtaa cccgccatgg ttggttctag     4560

atagacttta ggaaaatctc ttctcagtaa aaaaaaaaaa aaaaatctgt cagtaacagg     4620

tttcttgaac agaagtcctt gatattgata aagtcaaatt ggccactttg gccctgctgg     4680

catatgtttg ggggtcttca tttatttatt ttttaatcca atagcattga cttttattca     4740

ttcatgttaa gtcacctgaa atggtatctg ttgcatttaa atgctcaatt aatgtaaatg     4800

gctgaacaaa tccattttaa tggatattca atccattaaa aaaactcaat atcccacata     4860

aggtcactta acatagcctc atgacaactc ccacaccaaa acagtacttt attttgtaaa     4920

ttttgaccat tattactccc atgttatggt cttttcagct gtcaagcaaa caaggtgaag     4980

aaaaaattta gttagatggg ggttgcacct ggaaaataaa tttcttaaac tccatataca     5040

tgtttcaaat ctgctgggtc ccaagtccat ctatgaattc ccaggctgcc agtatcatat     5100

gcagcatact aaagctacgc tatctgaata gcttattaat tctgcatata tcaggtcaac     5160

cgatgtgtca acctgtaaca gactgcgaca cttttaactg aacatggcaa aatattcact     5220

ctcttgaact ttacatcatc tttgatatca aacaatgagg caaatcctaa cagtatatca     5280

aaaaacaact tttgagtttt acaaaagatt gttcccatac tgattaatca ggcaagctaa     5340

ctcttaggnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     5400

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnaa ctctcccttc     5460

cccaaagaga acttgccaga gaaggctgac agggaccagt atgagcttct ctgcctgaac     5520

aacagtcggg cgccagtgga tgcgttcaag gagtaccacc tggcccaggt cccttctcat     5580

cctgtcgtgg cccgaagtgt ggatgccaag gaagacttga tctggaagct tctcagaaag     5640

gcgcaggtac ccccaccctc agtaccccca cccgcttggg tctggtggtg gggagggttt     5700

ccttccttcc tcctccttcc ctaacttcct gccactctgg aatattcaag tggcctgcct     5760

gtcataggac tgtactccat acagttgaaa ccatgacccc tcctctagct tgacccactg     5820

gacaggtttc taatccgaag ctggaacaga acagaatagg ttggagggtg atgcaatatt     5880

gtcaagactc taaggtgctc agaccccacc aacttcataa agacaaagcc atgactgagc     5940

tatgtctcag ggaggccgtg agatcctcta caggaggagg tcaacccagg ttcctgctct     6000

cagaatcatc ccggagttgc agatactctg tttcaacctg gtgtttcagt ttcttgtcta     6060

ccactgacat cataattctc tttcccttaa ttaggagaaa tttggaaaaa acaagtctcg     6120

gagcttccag ctctttggct ctccacccgg ccagagggac ctgctgttca aagactctgc     6180

tcttgggttt ttgaggatcc cctcgaaggt agattcggcg ctgtaccttg gctcccgcta     6240

cttgaccacc ttgaagaacc tcagggaaag tgagtgaggg ccaggcccac cctaagggca     6300

ggccggtgtg ggtggtgagc cttggctgag gccgtcgggg agcacctccc caccctccac     6360

ccccgcccgc tacagacagc ttggccctgc tctgcagtcg tcccttggtc acttttccag     6420

cccctggagg tcttcaccat ggtaggtggg acgcgaatgt gagcgtcttc ttgtggacca     6480

aatcggctga ccggtgtctc cacaggagca cgtcgcctgc tgataacgct gcgcaggacc     6540

ccgtgtgcgg cgggttgccc agccctggta gagcagtcag tttgcctctg gggaagtgag     6600

aggtacgaag acaccccgag agagccaggg cccttctggg atgaatccag agccctgggc     6660

cctgaacttg gccacgatac caccctgggc cagctcagct gtggctcttc ctctgctgga     6720

ggcttcaggc ggactcgggg tgaacgggga ggctgcactg ttgttacagc ctgttgaccg     6780

ctgtgtcccc gggcagctgc ggaggaggtg aaggcgcggt acaccagggt cgtgtggtgt     6840

gccgtgggac ccgaggagca gaagaagtgc cagcagtgga gccagcagag cggccagaac     6900

gtgacctgtg ccacggcgtc caccaccgac gactgcatcg tcctggtgct ggtagggggc     6960

ctgctgccgg cctgcaagct gtgcgggtgg ggggcacagg tcaccgcatc tggttggagg     7020

ggagcaaggg gctcagacgg tgctcccccc ccagggggga gcagggcatg ctcgtcctgc     7080

ctgcccagag tggggacaga cagagctttc tgtcctccag agtgtctact gtggacttcc     7140

cactcttctg atcttataga acaactcaca atgaatgcag gtaatctgga aaatttagaa     7200

agatgtgatg taaaaccaaa cagcaatgga gcctcacaag gggctaccac agttgagtgc     7260

gtgttagtca ctcagtcatg tctgacccct tgtggcccca tggactgtag ccctcctctg     7320

cccatggaat tctccaggca agaatactgg agtgggttgc catgcccttc tccaggggat     7380

cttcccgaac cagggcgttg aatccgagtc tcccacatag aagacagatt gtttaccatc     7440

tgagccagca ggaaagcacc tagcacatag ttaagagttn nnnnnnnnnn nnnnnnnnnn     7500

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     7560

nnnnnnnnnn nnnnnnnnng gggggtaaaa gaacccacct tccaatgcag gagacggtgg     7620

gttcaatccc tgggtccaag aagatccccc ttggaggagg aaatggcaaa ccccctccag     7680

tatccttgcc tggagatccc atacacagag gagcctgtgg gctacagtcc atggggtcgc     7740

aaagagtcgt tcacgtctta gtgactccac agcagccacg accgggccgc ctgttcccgg     7800

tctttgcagt gggagtgacg gcgtgaaagg cgtgcacggc cggtacagaa gtaatggtgc     7860

acgtggcgtt gcctcgggct gctcacatca atcctgctgc ttcactgggc acctgacgtc     7920

cgttctctta gagctgtaaa gacaggcagg gtgggaaata gcctcaccgt ggtgctgaag     7980

atatgctttg tcttggcaga aaggggaagc agatgccctg aacttggatg gaggatatgt     8040

ctacactgcg ggcaagtgtg gcctggtgcc tgtcctggca gagaaccgga gtaagtggag     8100

aagagtaccc cctggcttat tccctctggg cttcgagggc ggggtggaga gcagtaaccc     8160

cactcggtgg ttcatgcgga gacattaaaa tggacagata ggttcaaaca ggagaatcag     8220

gagaaagaat agatgaaagt ggctgtgtta cccatatggc ctagtgtggt gagaactgac     8280

agatgctcct ctgtcagatt gatttcctct ttttgatttt tgaaaagatt ttagtaagtt     8340

ataatataca tactgaaaag tgcacctaag tgtacaactc aagaacattt cacacactgg     8400

tgcatctcca agctctagtg cccacagcga gatacagcag gttccacaag tcctcttgcg     8460

tccaccagcc ctcttacccc ggcaagggta acgactcctg acgtcaaatg gcacaaatcg     8520

gctctgcccg tctttgagct tgatgtaaaa ggagttgcac agcaggtacc ttttaaaaag     8580

tcttttgctc agcaatatat ctcgttttgc agtattctgt tgtgactccg ctgcagttac     8640

ttatttattc tactgtgggg aagcatttgg gtaatttcca atggttggct gccgtggata     8700

gagttgctgt gaacatctgg atccttgtct tttggtgaac acatacatgc atttctgttg     8760

catggaactg ctgggatggt ctgtttggat ttgattctcg actgctgaga tttaaaagtt     8820

tgtgatttct caggtggaga aagacagata ccttctgatg tcactcctat gtgggatagt     8880

taaaaactaa gtgaataaac caaatcaagc aaaaacaaat acacagattc caggaacaga     8940

gtggtggata agaaaacaga gcaagagatg tgggggtaga gggaaatgtg gtaatggggg     9000

taggtgatgg tatggaaact aaacttttgg tggtcagcaa ctgtcaggta aggggcttcc     9060

ccagtgggca gtgataaaga atacgcctgc gatgcgagag agtcaagaga catgggctcg     9120

atccctgggt taggagatcc cctgaaggag gaaatgacaa cccactccag tattcttgcc     9180

tggnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     9240

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnttgacct agccccaaca     9300

gaaagagact cacagacatg ctgagcacac tggtacccaa ggcgggtggg accagggaga     9360

gccacagact gggagttcgg gcttggtaga tgcaagctgt tacttttaga acggataaac     9420

ggcaagcccc tgctgtacag tacaggaaac tgtgtctggt ttcctggata aaccataatg     9480

gaagcaaata taaaaagaca aatgtgtata tgtgtttaac tgagtcactt tgccatacgg     9540

caaagatcga cacgacactg tcaatcaact acacgtcagt ttaaaaaaag aacttaaaaa     9600

cacagcgttg ggttgaactg aaaacaaaaa ccagaaaagg aagaaacaca gtgaagtcta     9660

ttctacaatg ccatttattt atgttgaaaa caaacgtata caaagccatg ccaatatgca     9720

tttttcaata tgtgggtacc tttggaaaat aaatgaacac actaaacgat gtgtttaatg     9780

acattttgct tctctttatt ctttcagaat cctccaaaca cagtagccta gattgtgtgc     9840

tgagaccaac ggaaggtgag ttcagggtca agggtacatt cttgtccctg gaggaggaga     9900

ggttgggaac ttaaaaaaaa aaaactcaca gagatgcagc catagaagct gtgagttctt     9960

tgcagatgcc agtcattcag agatgagagt gctgggattc acgtcacatg gaccctcaca    10020

catggcagag aaatcttaga gatcctcact gtgtcctgag cacggggaag gaggggtgag    10080

ccatccccat ctcgggcggg atgaagaaac agacccctag atctcactca tagcccatgg    10140

ataatactgt gcagatcctg cccggaacca gggtcccttg tgctaaatcc aatgcgctgt    10200

tcaaaagcca agccacacca ccctaaagag ctggtgccct ccctcggctt ggggtaaaag    10260

agtgacattt gccgacaaaa agactctacc agttttgacc taccaggagg ggatctccac    10320

cccacttaag cttaagctgt gttggtctat ttgacactga ccagtcatct ggggggatcg    10380

ttgcctagcg atgcttctta acctttgtgg gcctaggttg cactctgtgc aatagagtcc    10440

atggaccagc ccctgggagg ttgacttgct cttccgtttg accaagggta ccttgccgtg    10500

gcagttgtca ggaaagcaaa tgaggggctc acatggaatt ctctgaaaga caagaagtcg    10560

tgccacaccg ccgtggacag gactgcaggc tggaacatcc ccatgggcct gatcgtcaac    10620

cagacaggct cctgcgcatt tggtaggagt cctgannnnn nnnnnnnnnn nnnnnnnnnn    10680

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    10740

nnnnnnnnnn nnnnnggtac caggtgccct ggtaaaaagc agggttccta ttactgagga    10800

aaaggggaga gcacaacctg aacattttgg agcttctgat acaatggcca tggagttcat    10860

caggctgagt cccctgctct aggctgcgag gatggaaccc tttgtacagt catagaccct    10920

cttctccagc cccagtcagg ttgcctatag tctcaagttt tgctgaatcc tgttggtgca    10980

caggttggtg gtaacttgtt actatgtgtt ataatgactg tgttctgtct ggccttggtc    11040

agaccaagcc acatctgtca cctgttaggc agagaccact taatcttaac acaggtagga    11100

agagctggct ccccatgttt cttgctctgc agatgaattc tttagtcaga gctgtgcccc    11160

tggggctgac ccgaaatcca gactctgtgc cttgtgtgct ggcgatgacc agggcctgga    11220

caagtgtgtg cccaactcta aggagaagta ctatggctat accggggctt tcaggtgagt    11280

gttgtggcca ggcttcatca ggacagggcc ctggccctca gcctccagga tcttggcaca    11340

tcacatttca tttttttttt cctctttgaa aaatatattt cccttcaatt ttgaattggg    11400

aggatgactg cttaacaatg ttgtgttggc ctcctgcaaa agaaaatcac ccgtaagtac    11460

cagaagtaaa acgcacttgg cctccttcgc tcccccctgc cccgtggaac accgctgtat    11520

atcgctgagc accaagttga gctccctgcc tggtacagcg actctctgtt tcacacgtgg    11580

tgatgtttac atttcagagc ttctctctca gttcgtccca ccctctcctt cgccctgctg    11640

tgcccgcaag tctttggcac tgcattgcta aggggcccga tgtggtctgt cgggggcagc    11700

ctggggatca gctgatgggc gggctgggga gggctcctcc cacaacaccc accatcagac    11760

tgaccccggg gctgtctgga cctcagctct gctggcaccc cttcctgtgt cctggaacca    11820

aggttgatct cagtggacct cagtggcatg ttcagaatca gagagggaga ggttgaggta    11880

taagtccttt cgggaactca gttttatggg gaagattctc tttcccgtag gcgccacctt    11940

ctcccgcagc ctaggtagtt atgtctcacg tttttctgct ctctttgatt ttggccttag    12000

aaatggcaga gagagagagt gttgcagagt tattctccaa ggcaatggca ccccactcca    12060

gtactcctgc ctgggaaaat cccatggatg gagggagcct ggtgggctgc agtccatggg    12120

gtcgctaaga gtcaaggcat gacttagtga cttcactttc acttttcact ttcatgcatt    12180

tggagaagga attnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    12240

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnatatttt    12300

gtctttcttt tttctatttg cttccatgtt tcagtttttg gaatgtgtat tataaatagc    12360

tatgaaaatt ctaatagtgt ttacctctct ggcaatgttt tgattctctg gaacaattta    12420

ggtgcctggc tgaggacgtt ggggacgttg cctttgtgaa aaacgacaca gtctgggaga    12480

acacgaatgg gtaggtaaag gtgttttcct ttcccccttc aagagcacga tccttgccgt    12540

caccaacaga gcctactgtt gtggcagtcc cagcgcgggt tggaaaagaa tttcctgaca    12600

caaagtattt cagcaaggag tgactttata agaacaagga gcagagataa cgagggtctg    12660

caggcacagc gggccgacct cctgaccagg gatagttgac caaatgctgt tggaacagca    12720

actaggctca agggagaact gactctttcc tgggttagta gccaactttt ataacctcga    12780

gacgaaaatt gctgctggaa gggtggcatt aggtgattgg ttagggcgct agagagtgag    12840

taccggggta ggcatttttt cctgttaata atacggggtc aggaaactgg tcagtaagga    12900

tcaggtgggc ttttggcaat ggttgcaatg gggctcagtc agttccagag gtgaccttga    12960

ttctgagcca cagaagcaca ctatctnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    13020

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    13080

nnnnnnccac caatcacttt ctgtcttacc tattgtgggc atatgacaga aatggaatcc    13140

tatgataagt ggtcttctgt gattggcttg tcttattttg catcatggtt ttcatccggc    13200

gtggggtagc atgtgttaga acttgacttc ttcttcttgt tgctgagtaa gactccatcg    13260

tggagcactg gtatttgata cgtttgaagt ctgtataact tgaggagctt tctttgttct    13320

ccttcacgtg tgtgcatttg aagagggccg gtgggtggtg acagccccag aaaggaggct    13380

ttgactcagc cgggcagccg tggctgatgc agccttctct ctggtctcca gagagagcac    13440

tgcagactgg gctaagaact tgaatcgtga ggacttcagg ttgctctgcc tcgatggcac    13500

caggaagcct gtgacggagg ctcagagctg ccacctggcg gtggccccga atcacgctgt    13560

ggtgtctcgg agcgataggg cagcacacgt gaaacaggtg ctgctccacc agcaggtaag    13620

gatcacaggg cctcctgcct gtgcttacct tcaggggctc ccctcaggtg agcaaccaca    13680

gagctcagcg gatccnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    13740

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnctgat    13800

cctgcacagc agagattgcc tcccaagtcc ataatctctc ctcttttcct cagctggtct    13860

cttactgtct gcccttctga cataggctct gtttgggaaa aatggaaaaa actgcccgga    13920

caagttttgt ttgttcaaat ctgaaaccaa aaaccttctg ttcaatgaca acactgagtg    13980

tctggccaaa cttggaggca gaccaacgta tgaagaatat ttggggacag agtatgtcac    14040

ggccattgcc aacctgaaaa aatgctcaac ctcccgtaag ttggaatata aataagatca    14100

ctgagaaagc gtctgcatga aggtcaaagt tggaggnnnn nnnnnnnnnn nnnnnnnnnn    14160

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    14220

nnnnnnnnnn nnnnnnaagc ttgacctaca gtggggaaga agggcagagg gaagtctgtt    14280

ttagtgtctt ctttgattga tgtattgatt ccaagaaaaa aaaaaaagga atccttttct    14340

gaatctctgg cttcgttgtg tcccacagcg cttctggaag cctgcgcctt cctgacgagg    14400

taaagcctgc aaagaagcta gcctgcctcc ctgggcctca gctcctcccg tctctcagcc    14460

ccaatctcca ggcgcgaggg accttcctct cccttcctga agtcggattt tgccaagctc    14520

atcagtattt acaattccct gctgtcattt tagcaagaaa taaaattaga aatgctgttg    14580

attttcattc cctataaaat gccaattatc ttctctcaaa tgtatactga aatcgtgtct    14640

ggaccaa                                                              14647


<210>  6
<211>  708
<212>  PRT
<213>  Bos taurus

<400>  6

Met Lys Leu Phe Val Pro Ala Leu Leu Ser Leu Gly Ala Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala Ala Pro Arg Lys Asn Val Arg Trp Cys Thr Ile Ser Gln 
            20                  25                  30          


Pro Glu Trp Phe Lys Cys Arg Arg Trp Gln Trp Arg Met Lys Lys Leu 
        35                  40                  45              


Gly Ala Pro Ser Ile Thr Cys Val Arg Arg Ala Phe Ala Leu Ala Cys 
    50                  55                  60                  


Ile Arg Ala Ile Ala Glu Lys Lys Ala Asp Ala Val Thr Leu Asp Gly 
65                  70                  75                  80  


Gly Met Val Phe Glu Ala Gly Arg Asp Pro Tyr Lys Leu Arg Pro Val 
                85                  90                  95      


Ala Ala Glu Ile Tyr Gly Thr Lys Glu Ser Pro Gln Thr His Tyr Tyr 
            100                 105                 110         


Ala Val Ala Val Val Lys Lys Gly Ser Asn Phe Gln Leu Asp Gln Leu 
        115                 120                 125             


Gln Gly Arg Lys Ser Cys His Thr Gly Leu Gly Arg Ser Ala Gly Trp 
    130                 135                 140                 


Val Ile Pro Met Gly Ile Leu Arg Pro Tyr Leu Ser Trp Thr Glu Ser 
145                 150                 155                 160 


Leu Glu Pro Leu Gln Gly Ala Val Ala Lys Phe Phe Ser Ala Ser Cys 
                165                 170                 175     


Val Pro Cys Ile Asp Arg Gln Ala Tyr Pro Asn Leu Cys Gln Leu Cys 
            180                 185                 190         


Lys Gly Glu Gly Glu Asn Gln Cys Ala Cys Ser Ser Arg Glu Pro Tyr 
        195                 200                 205             


Phe Gly Tyr Ser Gly Ala Phe Lys Cys Leu Gln Asp Gly Ala Gly Asp 
    210                 215                 220                 


Val Ala Phe Val Lys Glu Thr Thr Val Phe Glu Asn Leu Pro Glu Lys 
225                 230                 235                 240 


Ala Asp Arg Asp Gln Tyr Glu Leu Leu Cys Leu Asn Asn Ser Arg Ala 
                245                 250                 255     


Pro Val Asp Ala Phe Lys Glu Tyr His Leu Ala Gln Val Pro Ser His 
            260                 265                 270         


Pro Val Val Ala Arg Ser Val Asp Ala Lys Glu Asp Leu Ile Trp Lys 
        275                 280                 285             


Leu Leu Arg Lys Ala Gln Glu Lys Phe Gly Lys Asn Lys Ser Arg Ser 
    290                 295                 300                 


Phe Gln Leu Phe Gly Ser Pro Pro Gly Gln Arg Asp Leu Leu Phe Lys 
305                 310                 315                 320 


Asp Ser Ala Leu Gly Phe Leu Arg Ile Pro Ser Lys Val Asp Ser Ala 
                325                 330                 335     


Leu Tyr Leu Gly Ser Arg Tyr Leu Thr Thr Leu Lys Asn Leu Arg Glu 
            340                 345                 350         


Thr Ala Glu Glu Val Lys Ala Arg Tyr Thr Arg Val Val Trp Cys Ala 
        355                 360                 365             


Val Gly Pro Glu Glu Gln Lys Lys Cys Gln Gln Trp Ser Gln Gln Ser 
    370                 375                 380                 


Gly Gln Asn Val Thr Cys Ala Thr Ala Ser Thr Thr Asp Asp Cys Ile 
385                 390                 395                 400 


Val Leu Val Leu Lys Gly Glu Ala Asp Ala Leu Asn Leu Asp Gly Gly 
                405                 410                 415     


Tyr Val Tyr Thr Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu 
            420                 425                 430         


Asn Arg Lys Ser Ser Lys His Ser Ser Leu Asp Cys Val Leu Arg Pro 
        435                 440                 445             


Thr Glu Gly Tyr Leu Ala Val Ala Val Val Arg Lys Ala Asn Glu Gly 
    450                 455                 460                 


Leu Thr Trp Asn Ser Leu Lys Asp Lys Lys Ser Cys His Thr Ala Val 
465                 470                 475                 480 


Asp Arg Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Ile Val Asn Gln 
                485                 490                 495     


Thr Gly Ser Cys Ala Phe Asp Glu Phe Phe Ser Gln Ser Cys Ala Pro 
            500                 505                 510         


Gly Ala Asp Pro Lys Ser Arg Leu Cys Ala Leu Cys Ala Gly Asp Asp 
        515                 520                 525             


Gln Gly Leu Asp Lys Cys Val Pro Asn Ser Lys Glu Lys Tyr Tyr Gly 
    530                 535                 540                 


Tyr Thr Gly Ala Phe Arg Cys Leu Ala Glu Asp Val Gly Asp Val Ala 
545                 550                 555                 560 


Phe Val Lys Asn Asp Thr Val Trp Glu Asn Thr Asn Gly Glu Ser Thr 
                565                 570                 575     


Ala Asp Trp Ala Lys Asn Leu Asn Arg Glu Asp Phe Arg Leu Leu Cys 
            580                 585                 590         


Leu Asp Gly Thr Arg Lys Pro Val Thr Glu Ala Gln Ser Cys His Leu 
        595                 600                 605             


Ala Val Ala Pro Asn His Ala Val Val Ser Arg Ser Asp Arg Ala Ala 
    610                 615                 620                 


His Val Lys Gln Val Leu Leu His Gln Gln Ala Leu Phe Gly Lys Asn 
625                 630                 635                 640 


Gly Lys Asn Cys Pro Asp Lys Phe Cys Leu Phe Lys Ser Glu Thr Lys 
                645                 650                 655     


Asn Leu Leu Phe Asn Asp Asn Thr Glu Cys Leu Ala Lys Leu Gly Gly 
            660                 665                 670         


Arg Pro Thr Tyr Glu Glu Tyr Leu Gly Thr Glu Tyr Val Thr Ala Ile 
        675                 680                 685             


Ala Asn Leu Lys Lys Cys Ser Thr Ser Pro Leu Leu Glu Ala Cys Ala 
    690                 695                 700                 


Phe Leu Thr Arg 
705             


<210>  7
<211>  2133
<212>  DNA
<213>  Homo sapiens

<400>  7
catgaaactt gtcttcctcg tcctgctgtt cctcggggcc ctcggactgt gtctggctgg       60

ccgtaggaga gggagtgttc agtggtgcgc cgtatcccaa cccgaggcca caaaatgctt      120

ccaatggcaa aggaatatga gaagagtgcg tggccctcct gtcagctgca taaagagaga      180

ctcccccatc cagtgtatcc aggccattgc ggaaaacagg gccgatgctg tgacccttga      240

tggtggtttc atatacgagg caggcctggc cccctacaaa ctgcgacctg tagcggcgga      300

agtctacggg accgaaagac agccacgaac tcactattat gccgtggctg tggtgaagaa      360

gggcggcagc tttcagctga acgaactgca aggtctgaag tcctgccaca caggccttcg      420

caggaccgct ggatggaatg tccctatagg gacacttcgt ccattcttga attggacggg      480

tccacctgag cccattgagg cagctgtggc caggttcttc tcagccagct gtgttcccgg      540

tgcagataaa ggacagttcc ccaacctgtg tcgcctgtgt gcggggacag gggaaaacaa      600

atgtgccttc tcctcccagg aaccgtactt cagctactct ggtgccttca agtgtctgag      660

agacggggct ggagacgtgg cttttatcag agagagcaca gtgtttgagg acctgtcaga      720

cgaggctgaa agggacgagt atgagttact ctgcccagac aacactcgga agccagtgga      780

caagttcaaa gactgccatc tggcccgggt cccttctcat gccgttgtgg cacgaagtgt      840

gaatggcaag gaggatgcca tctggaatct tctccgccag gcacaggaaa agtttggaaa      900

ggacaagtca ccgaaattcc agctctttgg ctcccctagt gggcagaaag atctgctgtt      960

caaggactct gccattgggt cttcgagggt gcccccgagg atagattctg ggctgtacct     1020

tggctccggc tacttcactg ccatccagaa cttgaggaaa agtgaggagg aagtggctgc     1080

ccggcgtgcg cgggttgtgt ggtgtgcggt gggcgagcag gagctgcgca agtgtaacca     1140

gtggagtggc ttgagcgaag gcagcgtgac ctgctcctcg gcctccacca cagaggactg     1200

cattgccctg aaaggagaag ctgatgccat gagtttggat ggagggtatg tgtacactgc     1260

aggcaaatgt ggtttggtgc ctgtcctggc agagaactac aaatcccaac aaagcagtga     1320

ccctgatcct aactgtgtgg atagacctgt ggaaggatat cttgctgtgg cggtggttag     1380

gagatcagac actagcctta cctggaactc tgtgaaaggc aagaagtcct gccacaccgc     1440

cgtggacagg actgcaggct ggaatatccc catgggcctg ctcttcaacc agacgggctc     1500

ctgcaaattt gatgaatatt tcagtcaaag ctgtgcccct gggtctgacc cgagatctaa     1560

tctctgtgct ctgtgtattg gcgacgagca gggtgagaat aagtgcgtgc ccaacagcaa     1620

tgagagatac tacggctaca ctggggcttt ccggtgcctg gctgagaatg ctggagacgt     1680

tgcatttgtg aaagatgtca ctgtcttgca gaacactgat ggaaataaca atgacgcatg     1740

ggctaaggat ttgaagctgg cagactttgc gctgctgtgc ctcgatggca aacggaagcc     1800

tgtgactgag gctagaagct gccatcttgc catggccccg aatcatgccg tggtgtctcg     1860

gatggataag gtggaacgcc tgaaacaggt gttgctccac caacaggcta aatttgggag     1920

aaatggatct gactgcccgg acaagttttg cttattccag tctgaaacca aaaaccttct     1980

gttcaatgac aacactgagt gtctggccag actccatggc aaaacaacat atgaaaaata     2040

tttgggacca cagtatgtcg caggcattac taatctgaaa aagtgctcaa cctcccccct     2100

cctggaagcc tgtgaattcc tcaggaagta aaa                                  2133


<210>  8
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  8

Glu Asp Cys Ile Ala Leu Lys Gly Glu Ala Asp Ala 
1               5                   10          


<210>  9
<211>  709
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Lys Leu Val Phe Leu Val Leu Leu Phe Leu Gly Ala Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala Gly Arg Arg Arg Gly Ser Val Gln Trp Cys Ala Val Ser 
            20                  25                  30          


Gln Pro Glu Ala Thr Lys Cys Phe Gln Trp Gln Arg Asn Met Arg Arg 
        35                  40                  45              


Val Arg Gly Pro Pro Val Ser Cys Ile Lys Arg Asp Ser Pro Ile Gln 
    50                  55                  60                  


Cys Ile Gln Ala Ile Ala Glu Asn Arg Ala Asp Ala Val Thr Leu Asp 
65                  70                  75                  80  


Gly Gly Phe Ile Tyr Glu Ala Gly Leu Ala Pro Tyr Lys Leu Arg Pro 
                85                  90                  95      


Val Ala Ala Glu Val Tyr Gly Thr Glu Arg Gln Pro Arg Thr His Tyr 
            100                 105                 110         


Tyr Ala Val Ala Val Val Lys Lys Gly Gly Ser Phe Gln Leu Asn Glu 
        115                 120                 125             


Leu Gln Gly Leu Lys Ser Cys His Thr Gly Leu Arg Arg Thr Ala Gly 
    130                 135                 140                 


Trp Asn Val Pro Ile Gly Thr Leu Arg Pro Phe Leu Asn Trp Thr Gly 
145                 150                 155                 160 


Pro Pro Glu Pro Ile Glu Ala Ala Val Ala Arg Phe Phe Ser Ala Ser 
                165                 170                 175     


Cys Val Pro Gly Ala Asp Lys Gly Gln Phe Pro Asn Leu Cys Arg Leu 
            180                 185                 190         


Cys Ala Gly Thr Gly Glu Asn Lys Cys Ala Phe Ser Ser Gln Glu Pro 
        195                 200                 205             


Tyr Phe Ser Tyr Ser Gly Ala Phe Lys Cys Leu Arg Asp Gly Ala Gly 
    210                 215                 220                 


Asp Val Ala Phe Ile Arg Glu Ser Thr Val Phe Glu Asp Leu Ser Asp 
225                 230                 235                 240 


Glu Ala Glu Arg Asp Glu Tyr Glu Leu Leu Cys Pro Asp Asn Thr Arg 
                245                 250                 255     


Lys Pro Val Asp Lys Phe Lys Asp Cys His Leu Ala Arg Val Pro Ser 
            260                 265                 270         


His Ala Val Val Ala Arg Ser Val Asn Gly Lys Glu Asp Ala Ile Trp 
        275                 280                 285             


Asn Leu Leu Arg Gln Ala Gln Glu Lys Phe Gly Lys Asp Lys Ser Pro 
    290                 295                 300                 


Lys Phe Gln Leu Phe Gly Ser Pro Ser Gly Gln Lys Asp Leu Leu Phe 
305                 310                 315                 320 


Lys Asp Ser Ala Ile Gly Ser Ser Arg Val Pro Pro Arg Ile Asp Ser 
                325                 330                 335     


Gly Leu Tyr Leu Gly Ser Gly Tyr Phe Thr Ala Ile Gln Asn Leu Arg 
            340                 345                 350         


Lys Ser Glu Glu Glu Val Ala Ala Arg Arg Ala Arg Val Val Trp Cys 
        355                 360                 365             


Ala Val Gly Glu Gln Glu Leu Arg Lys Cys Asn Gln Trp Ser Gly Leu 
    370                 375                 380                 


Ser Glu Gly Ser Val Thr Cys Ser Ser Ala Ser Thr Thr Glu Asp Cys 
385                 390                 395                 400 


Ile Ala Leu Lys Gly Glu Ala Asp Ala Met Ser Leu Asp Gly Gly Tyr 
                405                 410                 415     


Val Tyr Thr Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu Asn 
            420                 425                 430         


Tyr Lys Ser Gln Gln Ser Ser Asp Pro Asp Pro Asn Cys Val Asp Arg 
        435                 440                 445             


Pro Val Glu Gly Tyr Leu Ala Val Ala Val Val Arg Arg Ser Asp Thr 
    450                 455                 460                 


Ser Leu Thr Trp Asn Ser Val Lys Gly Lys Lys Ser Cys His Thr Ala 
465                 470                 475                 480 


Val Asp Arg Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Leu Phe Asn 
                485                 490                 495     


Gln Thr Gly Ser Cys Lys Phe Asp Glu Tyr Phe Ser Gln Ser Cys Ala 
            500                 505                 510         


Pro Gly Ser Asp Pro Arg Ser Asn Leu Cys Ala Leu Cys Ile Gly Asp 
        515                 520                 525             


Glu Gln Gly Glu Asn Lys Cys Val Pro Asn Ser Asn Glu Arg Tyr Tyr 
    530                 535                 540                 


Gly Tyr Thr Gly Ala Phe Arg Cys Leu Ala Glu Asn Ala Gly Asp Val 
545                 550                 555                 560 


Ala Phe Val Lys Asp Val Thr Val Leu Gln Asn Thr Asp Gly Asn Asn 
                565                 570                 575     


Asn Asp Ala Trp Ala Lys Asp Leu Lys Leu Ala Asp Phe Ala Leu Leu 
            580                 585                 590         


Cys Leu Asp Gly Lys Arg Lys Pro Val Thr Glu Ala Arg Ser Cys His 
        595                 600                 605             


Leu Ala Met Ala Pro Asn His Ala Val Val Ser Arg Met Asp Lys Val 
    610                 615                 620                 


Glu Arg Leu Lys Gln Val Leu Leu His Gln Gln Ala Lys Phe Gly Arg 
625                 630                 635                 640 


Asn Gly Ser Asp Cys Pro Asp Lys Phe Cys Leu Phe Gln Ser Glu Thr 
                645                 650                 655     


Lys Asn Leu Leu Phe Asn Asp Asn Thr Glu Cys Leu Ala Arg Leu His 
            660                 665                 670         


Gly Lys Thr Thr Tyr Glu Lys Tyr Leu Gly Pro Gln Tyr Val Ala Gly 
        675                 680                 685             


Ile Thr Asn Leu Lys Lys Cys Ser Thr Ser Pro Leu Leu Glu Ala Cys 
    690                 695                 700                 


Glu Phe Leu Arg Lys 
705                 


