                         SEQUENCE LISTING

<110>  SANOFI
 
<120>  Improvement of expression and folding in the manufacturing process of CD-RAP by using a CD-RAP precursor protein

<130>  DE2015/094 WO

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Pro Met Pro Lys Leu Ala Asp Arg Lys Leu Cys Ala Asp Gln Glu 
1               5                   10                  15      


Cys Ser His Pro Ile Ser Met Ala Val Ala Leu Gln Asp Tyr Met Ala 
            20                  25                  30          


Pro Asp Cys Arg Phe Leu Thr Ile His Arg Gly Gln Val Val Tyr Val 
        35                  40                  45              


Phe Ser Lys Leu Lys Gly Arg Gly Arg Leu Phe Trp Gly Gly Ser Val 
    50                  55                  60                  


Gln Gly Asp Tyr Tyr Gly Asp Leu Ala Ala Arg Leu Gly Tyr Phe Pro 
65                  70                  75                  80  


Ser Ser Ile Val Arg Glu Asp Gln Thr Leu Lys Pro Gly Lys Val Asp 
                85                  90                  95      


Val Lys Thr Asp Lys Trp Asp Phe Tyr Cys Gln 
            100                 105         


<210>  2
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-sequence

<400>  2

Met Ala Thr Thr Ser Thr 
1               5       


<210>  3
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-sequence

<400>  3

Met Ala Thr Thr Leu Thr 
1               5       


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-sequence

<400>  4

Met Ala Thr Thr Ser Thr Gly 
1               5           


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-sequence

<400>  5

Met Ala Thr Thr Leu Thr Gly 
1               5           


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-sequence

<400>  6

Met Ala Thr Thr Ser Thr Gly Asn 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-sequence

<400>  7

Met Ala Thr Thr Leu Thr Gly Asn 
1               5               


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-sequence

<400>  8

Met Ala Thr Thr Ser Thr Gly Asn Ser 
1               5                   


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-sequence

<400>  9

Met Ala Thr Thr Leu Thr Gly Asn Ser 
1               5                   


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-sequence

<400>  10

Met Ala Thr Thr Ser Thr Gly Asn Ser Ala 
1               5                   10  


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-sequence

<400>  11

Met Ala Thr Thr Leu Thr Gly Asn Ser Ala 
1               5                   10  


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-sequence

<400>  12

Met Ala Thr Thr Ser Thr Arg 
1               5           


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-sequence

<400>  13

Met Ala Thr Thr Leu Thr Arg 
1               5           


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-sequence

<400>  14

Met Ala Thr Thr Ser Thr Gly Asn Ser Ala Arg 
1               5                   10      


<210>  15
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-sequence

<400>  15

Met Ala Thr Thr Leu Thr Gly Asn Ser Ala Arg 
1               5                   10      


<210>  16
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-sequence

<400>  16

Met Ala Thr Thr Ser Thr Leu Thr Thr His Trp His Trp His Gly Asn 
1               5                   10                  15      


Ser Ala Arg 
            


<210>  17
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-sequence

<400>  17

Met Ala Thr Thr Ser Thr Gly Asn Ser Ala His Phe Gln His His His 
1               5                   10                  15      


Gly Ser Leu Ala Arg 
            20      


<210>  18
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-sequence

<400>  18

Met Ala Thr Thr Ser Thr Gly Asn Ser Ala His Phe Gln His His His 
1               5                   10                  15      


Gly Ser Leu Ala Arg 
            20      


<210>  19
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-sequence

<400>  19

Met Ala Thr Thr Ser Thr Gly Asn Ser Ala Arg Phe Val Asn Gln His 
1               5                   10                  15      


Leu His His His His His His His His Gly Gly Gly Glu Asn Gln Gln 
            20                  25                  30          


Gln Arg 
        


<210>  20
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD-RAP precursor protein

<400>  20

Met Ala Thr Thr Ser Thr Gly Asn Ser Ala Arg Phe Val Asn Gln His 
1               5                   10                  15      


Leu His His His His His His His His Gly Gly Gly Glu Asn Gln Gln 
            20                  25                  30          


Gln Arg Gly Pro Met Pro Lys Leu Ala Asp Arg Lys Leu Cys Ala Asp 
        35                  40                  45              


Gln Glu Cys Ser His Pro Ile Ser Met Ala Val Ala Leu Gln Asp Tyr 
    50                  55                  60                  


Met Ala Pro Asp Cys Arg Phe Leu Thr Ile His Arg Gly Gln Val Val 
65                  70                  75                  80  


Tyr Val Phe Ser Lys Leu Lys Gly Arg Gly Arg Leu Phe Trp Gly Gly 
                85                  90                  95      


Ser Val Gln Gly Asp Tyr Tyr Gly Asp Leu Ala Ala Arg Leu Gly Tyr 
            100                 105                 110         


Phe Pro Ser Ser Ile Val Arg Glu Asp Gln Thr Leu Lys Pro Gly Lys 
        115                 120                 125             


Val Asp Val Lys Thr Asp Lys Trp Asp Phe Tyr Cys Gln 
    130                 135                 140     


<210>  21
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Pro Lys Leu Ala Asp Arg Lys Leu Cys Ala Asp Gln Glu Cys Ser 
1               5                   10                  15      


His Pro Ile Ser Met Ala Val Ala Leu Gln Asp Tyr Met Ala Pro Asp 
            20                  25                  30          


Cys Arg Phe Leu Thr Ile His Arg Gly Gln Val Val Tyr Val Phe Ser 
        35                  40                  45              


Lys Leu Lys Gly Arg Gly Arg Leu Phe Trp Gly Gly Ser Val Gln Gly 
    50                  55                  60                  


Asp Tyr Tyr Gly Asp Leu Ala Ala Arg Leu Gly Tyr Phe Pro Ser Ser 
65                  70                  75                  80  


Ile Val Arg Glu Asp Gln Thr Leu Lys Pro Gly Lys Val Asp Val Lys 
                85                  90                  95      


Thr Asp Lys Trp Asp Phe Tyr Cys Gln 
            100                 105 


