               SEQUENCE LISTING

<110> F. Hoffmann-La Roche AG et al.

<120> Pyridopyrazine compounds and their use in the treatment, amelioration or prevention of influenza

<130> Y2482 PCT

<150> US 62/220,817
<151> 20015-09-18

<160> 22

<170> BiSSAP 1.3

<210> 1
<211> 44
<212> RNA
<213> Artificial Sequence

<220> 
<223> m7G-capped RNA oligonucleotide

<400> 1
gggggaauac ucaagcuaug caucgcauua ggcacgucga agua                      44


<210> 2
<211> 15
<212> RNA
<213> Artificial Sequence

<220> 
<223> snatched cap sequence

<400> 2
gggggaauac ucaag                                                     15


<210> 3
<211> 211
<212> RNA
<213> Artificial Sequence

<220> 
<223> sequence of de novo synthesized viral mRNA; nucleotides 1-212

<400> 3
agcaaaagca ggguagauaa ucacucacug agugacauca aaaucauggc gucccaaggc     60

accaaacggu cuuacgaaca gauggagacu gauggagaac gccagaaugc cacugaaauc    120

agagcauccg ucggaaaaau gauuggugga auuggacgau ucuacaucca aaugugcaca    180

gaacuuaaac ucagugauua ugagggacgg u                                   211


<210> 4
<211> 120
<212> RNA
<213> Artificial Sequence

<220> 
<223> sequence of de novo synthesized viral mRNA; nucleotides 1425-1545

<400> 4
gcggggaguc uucgagcucu cggacgaaaa ggcagcgagc ccgaucgugc cuuccuuuga     60

caugaguaau gaaggaucuu auuucuucgg agacaaugca gaggaguacg acaauuaaag    120


<210> 5
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Label Extender 1 (LE1)

<400> 5
cccccttatg agttctcgtt t                                              21


<210> 6
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> Blocking Probe 1 (BP1)

<400> 6
tcgtcccatc tattagtgag tgactc                                         26


<210> 7
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Capture Extended 1 (CE1)

<400> 7
actgtagttt tagtaccgca gg                                             22


<210> 8
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Capture Extender 2 (CE2)

<400> 8
gttccgtggt ttgccagaat g                                              21


<210> 9
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Blocking Probe 2 (BP2)

<400> 9
cttgtctacc tctgactacc tctt                                           24


<210> 10
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Capture Extender 3 (CE3)

<400> 10
gcggtcttac ggtgacttt                                                 19


<210> 11
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Capture Extender (CE4)

<400> 11
agtctcgtag gcagcctttt                                                20


<210> 12
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Blocking Probe 3 (BP3)

<400> 12
tactaaccac cttaacctgc t                                              21


<210> 13
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Blocking Probe 4 (BP4)

<400> 13
aagatgtagg tttacacgtg tctt                                           24


<210> 14
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> Capture Extender 5 (CE5)

<400> 14
gaatttgagt cactaatact ccctgc                                         26


<210> 15
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Capture Extender 6 (CE6)

<400> 15
cccctcagaa gctcgagagc                                                20


<210> 16
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Capture Extender 7 (CE7)

<400> 16
ctgcttttcc gtcgctcgg                                                 19


<210> 17
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Capture Extender 8 (CE8)

<400> 17
gctagcacgg aaggaaactg                                                20


<210> 18
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Capture Extender 9 (CE9)

<400> 18
tactcattac ttcctagaat aaagaag                                        27


<210> 19
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Blocking Probe 5 (BP5)

<400> 19
cctctgttac gtctcctcat gc                                             22


<210> 20
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Label Extender 2 (LE2)

<400> 20
gatgattttt tttttttttt ttttttt                                        27


<210> 21
<211> 226
<212> RNA
<213> Artificial Sequence

<220> 
<223> sequence of de novo synthesized viral mRNA; nucleotides 1 to 212
      with capped primer

<400> 21
gggggaauac ucaagagcaa aagcagggua gauaaucacu cacugaguga caucaaaauc     60

auggcguccc aaggcaccaa acggucuuac gaacagaugg agacugaugg agaacgccag    120

aaugccacug aaaucagagc auccgucgga aaaaugauug guggaauugg acgauucuac    180

auccaaaugu gcacagaacu uaaacucagu gauuaugagg gacggu                   226


<210> 22
<211> 141
<212> RNA
<213> Artificial Sequence

<220> 
<223> sequence of de novo synthesized viral mRNA; nucleotides 1425-1545
      with polyA tail

<400> 22
gcggggaguc uucgagcucu cggacgaaaa ggcagcgagc ccgaucgugc cuuccuuuga     60

caugaguaau gaaggaucuu auuucuucgg agacaaugca gaggaguacg acaauuaaag    120

aaaaaaaaaa aaaaaaaaaa a                                              141


