                         SEQUENCE LISTING

<110>  Universitt Duisburg-Essen
 
<120>  Agents inhibiting Kallikrein-8 for use in the prevention or 
       treatment of Alzheimer's disease

<130>  P69914PC

<150>  EP 15002769.6
<151>  2015-09-25

<150>  EP 15003657.2
<151>  2015-12-22

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  substrate motif

<400>  1

Tyr Gly Arg Tyr 
1               


<210>  2
<211>  260
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(260)
<223>  pro-form sequence

<400>  2

Met Gly Arg Pro Pro Pro Cys Ala Ile Gln Pro Trp Ile Leu Leu Leu 
1               5                   10                  15      


Leu Phe Met Gly Ala Trp Ala Gly Leu Thr Arg Ala Gln Gly Ser Lys 
            20                  25                  30          


Ile Leu Glu Gly Arg Glu Cys Ile Pro His Ser Gln Pro Trp Gln Ala 
        35                  40                  45              


Ala Leu Phe Gln Gly Glu Arg Leu Ile Cys Gly Gly Val Leu Val Gly 
    50                  55                  60                  


Asp Arg Trp Val Leu Thr Ala Ala His Cys Lys Lys Gln Lys Tyr Ser 
65                  70                  75                  80  


Val Arg Leu Gly Asp His Ser Leu Gln Ser Arg Asp Gln Pro Glu Gln 
                85                  90                  95      


Glu Ile Gln Val Ala Gln Ser Ile Gln His Pro Cys Tyr Asn Asn Ser 
            100                 105                 110         


Asn Pro Glu Asp His Ser His Asp Ile Met Leu Ile Arg Leu Gln Asn 
        115                 120                 125             


Ser Ala Asn Leu Gly Asp Lys Val Lys Pro Val Gln Leu Ala Asn Leu 
    130                 135                 140                 


Cys Pro Lys Val Gly Gln Lys Cys Ile Ile Ser Gly Trp Gly Thr Val 
145                 150                 155                 160 


Thr Ser Pro Gln Glu Asn Phe Pro Asn Thr Leu Asn Cys Ala Glu Val 
                165                 170                 175     


Lys Ile Tyr Ser Gln Asn Lys Cys Glu Arg Ala Tyr Pro Gly Lys Ile 
            180                 185                 190         


Thr Glu Gly Met Val Cys Ala Gly Ser Ser Asn Gly Ala Asp Thr Cys 
        195                 200                 205             


Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Asp Gly Met Leu Gln Gly 
    210                 215                 220                 


Ile Thr Ser Trp Gly Ser Asp Pro Cys Gly Lys Pro Glu Lys Pro Gly 
225                 230                 235                 240 


Val Tyr Thr Lys Ile Cys Arg Tyr Thr Thr Trp Ile Lys Lys Thr Met 
                245                 250                 255     


Asp Asn Arg Asp 
            260 


<210>  3
<211>  260
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(260)
<223>  pro-form sequence

<400>  3

Met Gly Arg Pro Arg Pro Arg Ala Ala Lys Thr Trp Met Phe Leu Leu 
1               5                   10                  15      


Leu Leu Gly Gly Ala Trp Ala Gly His Ser Arg Ala Gln Glu Asp Lys 
            20                  25                  30          


Val Leu Gly Gly His Glu Cys Gln Pro His Ser Gln Pro Trp Gln Ala 
        35                  40                  45              


Ala Leu Phe Gln Gly Gln Gln Leu Leu Cys Gly Gly Val Leu Val Gly 
    50                  55                  60                  


Gly Asn Trp Val Leu Thr Ala Ala His Cys Lys Lys Pro Lys Tyr Thr 
65                  70                  75                  80  


Val Arg Leu Gly Asp His Ser Leu Gln Asn Lys Asp Gly Pro Glu Gln 
                85                  90                  95      


Glu Ile Pro Val Val Gln Ser Ile Pro His Pro Cys Tyr Asn Ser Ser 
            100                 105                 110         


Asp Val Glu Asp His Asn His Asp Leu Met Leu Leu Gln Leu Arg Asp 
        115                 120                 125             


Gln Ala Ser Leu Gly Ser Lys Val Lys Pro Ile Ser Leu Ala Asp His 
    130                 135                 140                 


Cys Thr Gln Pro Gly Gln Lys Cys Thr Val Ser Gly Trp Gly Thr Val 
145                 150                 155                 160 


Thr Ser Pro Arg Glu Asn Phe Pro Asp Thr Leu Asn Cys Ala Glu Val 
                165                 170                 175     


Lys Ile Phe Pro Gln Lys Lys Cys Glu Asp Ala Tyr Pro Gly Gln Ile 
            180                 185                 190         


Thr Asp Gly Met Val Cys Ala Gly Ser Ser Lys Gly Ala Asp Thr Cys 
        195                 200                 205             


Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Asp Gly Ala Leu Gln Gly 
    210                 215                 220                 


Ile Thr Ser Trp Gly Ser Asp Pro Cys Gly Arg Ser Asp Lys Pro Gly 
225                 230                 235                 240 


Val Tyr Thr Asn Ile Cys Arg Tyr Leu Asp Trp Ile Lys Lys Ile Ile 
                245                 250                 255     


Gly Ser Lys Gly 
            260 


<210>  4
<211>  987
<212>  PRT
<213>  Mus musculus

<400>  4

Met Ala Val Arg Arg Leu Gly Ala Ala Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Ala Ala Val Glu Glu Thr Leu Met Asp Ser Thr Thr Ala Thr Ala Glu 
            20                  25                  30          


Leu Gly Trp Met Val His Pro Pro Ser Gly Trp Glu Glu Val Ser Gly 
        35                  40                  45              


Tyr Asp Glu Asn Met Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val 
    50                  55                  60                  


Phe Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Lys Phe Ile Arg Arg 
65                  70                  75                  80  


Arg Gly Ala His Arg Ile His Val Glu Met Lys Phe Ser Val Arg Asp 
                85                  90                  95      


Cys Ser Ser Ile Pro Ser Val Pro Gly Ser Cys Lys Glu Thr Phe Asn 
            100                 105                 110         


Leu Tyr Tyr Tyr Glu Ala Asp Phe Asp Leu Ala Thr Lys Thr Phe Pro 
        115                 120                 125             


Asn Trp Met Glu Asn Pro Trp Val Lys Val Asp Thr Ile Ala Ala Asp 
    130                 135                 140                 


Glu Ser Phe Ser Gln Val Asp Leu Gly Gly Arg Val Met Lys Ile Asn 
145                 150                 155                 160 


Thr Glu Val Arg Ser Phe Gly Pro Val Ser Arg Asn Gly Phe Tyr Leu 
                165                 170                 175     


Ala Phe Gln Asp Tyr Gly Gly Cys Met Ser Leu Ile Ala Val Arg Val 
            180                 185                 190         


Phe Tyr Arg Lys Cys Pro Arg Ile Ile Gln Asn Gly Ala Ile Phe Gln 
        195                 200                 205             


Glu Thr Leu Ser Gly Ala Glu Ser Thr Ser Leu Val Ala Ala Arg Gly 
    210                 215                 220                 


Ser Cys Ile Ala Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr 
225                 230                 235                 240 


Cys Asn Gly Asp Gly Glu Trp Leu Val Pro Ile Gly Arg Cys Met Cys 
                245                 250                 255     


Lys Ala Gly Phe Glu Ala Val Glu Asn Gly Thr Val Cys Arg Gly Cys 
            260                 265                 270         


Pro Ser Gly Thr Phe Lys Ala Asn Gln Gly Asp Glu Ala Cys Thr His 
        275                 280                 285             


Cys Pro Ile Asn Ser Arg Thr Thr Ser Glu Gly Ala Thr Asn Cys Val 
    290                 295                 300                 


Cys Arg Asn Gly Tyr Tyr Arg Ala Asp Leu Asp Pro Leu Asp Met Pro 
305                 310                 315                 320 


Cys Thr Thr Ile Pro Ser Ala Pro Gln Ala Val Ile Ser Ser Val Asn 
                325                 330                 335     


Glu Thr Ser Leu Met Leu Glu Trp Thr Pro Pro Arg Asp Ser Gly Gly 
            340                 345                 350         


Arg Glu Asp Leu Val Tyr Asn Ile Ile Cys Lys Ser Cys Gly Ser Gly 
        355                 360                 365             


Arg Gly Ala Cys Thr Arg Cys Gly Asp Asn Val Gln Tyr Ala Pro Arg 
    370                 375                 380                 


Gln Leu Gly Leu Thr Glu Pro Arg Ile Tyr Ile Ser Asp Leu Leu Ala 
385                 390                 395                 400 


His Thr Gln Tyr Thr Phe Glu Ile Gln Ala Val Asn Gly Val Thr Asp 
                405                 410                 415     


Gln Ser Pro Phe Ser Pro Gln Phe Ala Ser Val Asn Ile Thr Thr Asn 
            420                 425                 430         


Gln Ala Ala Pro Ser Ala Val Ser Ile Met His Gln Val Ser Arg Thr 
        435                 440                 445             


Val Asp Ser Ile Thr Leu Ser Trp Ser Gln Pro Asp Gln Pro Asn Gly 
    450                 455                 460                 


Val Ile Leu Asp Tyr Glu Leu Gln Tyr Tyr Glu Lys Gln Glu Leu Ser 
465                 470                 475                 480 


Glu Tyr Asn Ala Thr Ala Ile Lys Ser Pro Thr Asn Thr Val Thr Val 
                485                 490                 495     


Gln Gly Leu Lys Ala Gly Ala Ile Tyr Val Phe Gln Val Arg Ala Arg 
            500                 505                 510         


Thr Val Ala Gly Tyr Gly Arg Tyr Ser Gly Lys Met Tyr Phe Gln Thr 
        515                 520                 525             


Met Thr Glu Ala Glu Tyr Gln Thr Ser Ile Lys Glu Lys Leu Pro Leu 
    530                 535                 540                 


Ile Val Gly Ser Ser Ala Ala Gly Leu Val Phe Leu Ile Ala Val Val 
545                 550                 555                 560 


Val Ile Ala Ile Val Cys Asn Arg Arg Gly Phe Glu Arg Ala Asp Ser 
                565                 570                 575     


Glu Tyr Thr Asp Lys Leu Gln His Tyr Thr Ser Gly His Met Thr Pro 
            580                 585                 590         


Gly Met Lys Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu 
        595                 600                 605             


Ala Val Arg Glu Phe Ala Lys Glu Ile Asp Ile Ser Cys Val Lys Ile 
    610                 615                 620                 


Glu Gln Val Ile Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly His 
625                 630                 635                 640 


Leu Lys Leu Pro Gly Lys Arg Glu Ile Phe Val Ala Ile Lys Thr Leu 
                645                 650                 655     


Lys Ser Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala 
            660                 665                 670         


Ser Ile Met Gly Gln Phe Asp His Pro Asn Val Ile His Leu Glu Gly 
        675                 680                 685             


Val Val Thr Lys Ser Thr Pro Val Met Ile Ile Thr Glu Phe Met Glu 
    690                 695                 700                 


Asn Gly Ser Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr 
705                 710                 715                 720 


Val Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys 
                725                 730                 735     


Tyr Leu Ala Asp Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn 
            740                 745                 750         


Ile Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu 
        755                 760                 765             


Ser Arg Phe Leu Glu Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ala 
    770                 775                 780                 


Leu Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Gln 
785                 790                 795                 800 


Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val 
                805                 810                 815     


Met Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Thr 
            820                 825                 830         


Asn Gln Asp Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro 
        835                 840                 845             


Pro Met Asp Cys Pro Ser Ala Leu His Gln Leu Met Leu Asp Cys Trp 
    850                 855                 860                 


Gln Lys Asp Arg Asn His Arg Pro Lys Phe Gly Gln Ile Val Asn Thr 
865                 870                 875                 880 


Leu Asp Lys Met Ile Arg Asn Pro Asn Ser Leu Lys Ala Met Ala Pro 
                885                 890                 895     


Leu Ser Ser Gly Ile Asn Leu Pro Leu Leu Asp Arg Thr Ile Pro Asp 
            900                 905                 910         


Tyr Thr Ser Phe Asn Thr Val Asp Glu Trp Leu Glu Ala Ile Lys Met 
        915                 920                 925             


Gly Gln Tyr Lys Glu Ser Phe Ala Asn Ala Gly Phe Thr Ser Phe Asp 
    930                 935                 940                 


Val Val Ser Gln Met Met Met Glu Asp Ile Leu Arg Val Gly Val Thr 
945                 950                 955                 960 


Leu Ala Gly His Gln Lys Lys Ile Leu Asn Ser Ile Gln Val Met Arg 
                965                 970                 975     


Ala Gln Met Asn Gln Ile Gln Ser Val Glu Val 
            980                 985         


<210>  5
<211>  986
<212>  PRT
<213>  Mus musculus

<400>  5

Met Ala Val Arg Arg Leu Gly Ala Ala Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Ala Ala Val Glu Glu Thr Leu Met Asp Ser Thr Thr Ala Thr Ala Glu 
            20                  25                  30          


Leu Gly Trp Met Val His Pro Pro Ser Gly Trp Glu Glu Val Ser Gly 
        35                  40                  45              


Tyr Asp Glu Asn Met Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val 
    50                  55                  60                  


Phe Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Lys Phe Ile Arg Arg 
65                  70                  75                  80  


Arg Gly Ala His Arg Ile His Val Glu Met Lys Phe Ser Val Arg Asp 
                85                  90                  95      


Cys Ser Ser Ile Pro Ser Val Pro Gly Ser Cys Lys Glu Thr Phe Asn 
            100                 105                 110         


Leu Tyr Tyr Tyr Glu Ala Asp Phe Asp Leu Ala Thr Lys Thr Phe Pro 
        115                 120                 125             


Asn Trp Met Glu Asn Pro Trp Val Lys Val Asp Thr Ile Ala Ala Asp 
    130                 135                 140                 


Glu Ser Phe Ser Gln Val Asp Leu Gly Gly Arg Val Met Lys Ile Asn 
145                 150                 155                 160 


Thr Glu Val Arg Ser Phe Gly Pro Val Ser Arg Asn Gly Phe Tyr Leu 
                165                 170                 175     


Ala Phe Gln Asp Tyr Gly Gly Cys Met Ser Leu Ile Ala Val Arg Val 
            180                 185                 190         


Phe Tyr Arg Lys Cys Pro Arg Ile Ile Gln Asn Gly Ala Ile Phe Gln 
        195                 200                 205             


Glu Thr Leu Ser Gly Ala Glu Ser Thr Ser Leu Val Ala Ala Arg Gly 
    210                 215                 220                 


Ser Cys Ile Ala Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr 
225                 230                 235                 240 


Cys Asn Gly Asp Gly Glu Trp Leu Val Pro Ile Gly Arg Cys Met Cys 
                245                 250                 255     


Lys Ala Gly Phe Glu Ala Val Glu Asn Gly Thr Val Cys Arg Gly Cys 
            260                 265                 270         


Pro Ser Gly Thr Phe Lys Ala Asn Gln Gly Asp Glu Ala Cys Thr His 
        275                 280                 285             


Cys Pro Ile Asn Ser Arg Thr Thr Ser Glu Gly Ala Thr Asn Cys Val 
    290                 295                 300                 


Cys Arg Asn Gly Tyr Tyr Arg Ala Asp Leu Asp Pro Leu Asp Met Pro 
305                 310                 315                 320 


Cys Thr Thr Ile Pro Ser Ala Pro Gln Ala Val Ile Ser Ser Val Asn 
                325                 330                 335     


Glu Thr Ser Leu Met Leu Glu Trp Thr Pro Pro Arg Asp Ser Gly Gly 
            340                 345                 350         


Arg Glu Asp Leu Val Tyr Asn Ile Ile Cys Lys Ser Cys Gly Ser Gly 
        355                 360                 365             


Arg Gly Ala Cys Thr Arg Cys Gly Asp Asn Val Gln Tyr Ala Pro Arg 
    370                 375                 380                 


Gln Leu Gly Leu Thr Glu Pro Arg Ile Tyr Ile Ser Asp Leu Leu Ala 
385                 390                 395                 400 


His Thr Gln Tyr Thr Phe Glu Ile Gln Ala Val Asn Gly Val Thr Asp 
                405                 410                 415     


Gln Ser Pro Phe Ser Pro Gln Phe Ala Ser Val Asn Ile Thr Thr Asn 
            420                 425                 430         


Gln Ala Ala Pro Ser Ala Val Ser Ile Met His Gln Val Ser Arg Thr 
        435                 440                 445             


Val Asp Ser Ile Thr Leu Ser Trp Ser Gln Pro Asp Gln Pro Asn Gly 
    450                 455                 460                 


Val Ile Leu Asp Tyr Glu Leu Gln Tyr Tyr Glu Lys Glu Leu Ser Glu 
465                 470                 475                 480 


Tyr Asn Ala Thr Ala Ile Lys Ser Pro Thr Asn Thr Val Thr Val Gln 
                485                 490                 495     


Gly Leu Lys Ala Gly Ala Ile Tyr Val Phe Gln Val Arg Ala Arg Thr 
            500                 505                 510         


Val Ala Gly Tyr Gly Arg Tyr Ser Gly Lys Met Tyr Phe Gln Thr Met 
        515                 520                 525             


Thr Glu Ala Glu Tyr Gln Thr Ser Ile Lys Glu Lys Leu Pro Leu Ile 
    530                 535                 540                 


Val Gly Ser Ser Ala Ala Gly Leu Val Phe Leu Ile Ala Val Val Val 
545                 550                 555                 560 


Ile Ala Ile Val Cys Asn Arg Arg Gly Phe Glu Arg Ala Asp Ser Glu 
                565                 570                 575     


Tyr Thr Asp Lys Leu Gln His Tyr Thr Ser Gly His Met Thr Pro Gly 
            580                 585                 590         


Met Lys Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala 
        595                 600                 605             


Val Arg Glu Phe Ala Lys Glu Ile Asp Ile Ser Cys Val Lys Ile Glu 
    610                 615                 620                 


Gln Val Ile Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly His Leu 
625                 630                 635                 640 


Lys Leu Pro Gly Lys Arg Glu Ile Phe Val Ala Ile Lys Thr Leu Lys 
                645                 650                 655     


Ser Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser 
            660                 665                 670         


Ile Met Gly Gln Phe Asp His Pro Asn Val Ile His Leu Glu Gly Val 
        675                 680                 685             


Val Thr Lys Ser Thr Pro Val Met Ile Ile Thr Glu Phe Met Glu Asn 
    690                 695                 700                 


Gly Ser Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr Val 
705                 710                 715                 720 


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr 
                725                 730                 735     


Leu Ala Asp Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile 
            740                 745                 750         


Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser 
        755                 760                 765             


Arg Phe Leu Glu Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ala Leu 
    770                 775                 780                 


Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Gln Tyr 
785                 790                 795                 800 


Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met 
                805                 810                 815     


Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Thr Asn 
            820                 825                 830         


Gln Asp Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro 
        835                 840                 845             


Met Asp Cys Pro Ser Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln 
    850                 855                 860                 


Lys Asp Arg Asn His Arg Pro Lys Phe Gly Gln Ile Val Asn Thr Leu 
865                 870                 875                 880 


Asp Lys Met Ile Arg Asn Pro Asn Ser Leu Lys Ala Met Ala Pro Leu 
                885                 890                 895     


Ser Ser Gly Ile Asn Leu Pro Leu Leu Asp Arg Thr Ile Pro Asp Tyr 
            900                 905                 910         


Thr Ser Phe Asn Thr Val Asp Glu Trp Leu Glu Ala Ile Lys Met Gly 
        915                 920                 925             


Gln Tyr Lys Glu Ser Phe Ala Asn Ala Gly Phe Thr Ser Phe Asp Val 
    930                 935                 940                 


Val Ser Gln Met Met Met Glu Asp Ile Leu Arg Val Gly Val Thr Leu 
945                 950                 955                 960 


Ala Gly His Gln Lys Lys Ile Leu Asn Ser Ile Gln Val Met Arg Ala 
                965                 970                 975     


Gln Met Asn Gln Ile Gln Ser Val Glu Val 
            980                 985     


<210>  6
<211>  986
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Leu Arg Arg Leu Gly Ala Ala Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Ala Ala Val Glu Glu Thr Leu Met Asp Ser Thr Thr Ala Thr Ala Glu 
            20                  25                  30          


Leu Gly Trp Met Val His Pro Pro Ser Gly Trp Glu Glu Val Ser Gly 
        35                  40                  45              


Tyr Asp Glu Asn Met Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val 
    50                  55                  60                  


Phe Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Lys Phe Ile Arg Arg 
65                  70                  75                  80  


Arg Gly Ala His Arg Ile His Val Glu Met Lys Phe Ser Val Arg Asp 
                85                  90                  95      


Cys Ser Ser Ile Pro Ser Val Pro Gly Ser Cys Lys Glu Thr Phe Asn 
            100                 105                 110         


Leu Tyr Tyr Tyr Glu Ala Asp Phe Asp Ser Ala Thr Lys Thr Phe Pro 
        115                 120                 125             


Asn Trp Met Glu Asn Pro Trp Val Lys Val Asp Thr Ile Ala Ala Asp 
    130                 135                 140                 


Glu Ser Phe Ser Gln Val Asp Leu Gly Gly Arg Val Met Lys Ile Asn 
145                 150                 155                 160 


Thr Glu Val Arg Ser Phe Gly Pro Val Ser Arg Ser Gly Phe Tyr Leu 
                165                 170                 175     


Ala Phe Gln Asp Tyr Gly Gly Cys Met Ser Leu Ile Ala Val Arg Val 
            180                 185                 190         


Phe Tyr Arg Lys Cys Pro Arg Ile Ile Gln Asn Gly Ala Ile Phe Gln 
        195                 200                 205             


Glu Thr Leu Ser Gly Ala Glu Ser Thr Ser Leu Val Ala Ala Arg Gly 
    210                 215                 220                 


Ser Cys Ile Ala Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr 
225                 230                 235                 240 


Cys Asn Gly Asp Gly Glu Trp Leu Val Pro Ile Gly Arg Cys Met Cys 
                245                 250                 255     


Lys Ala Gly Phe Glu Ala Val Glu Asn Gly Thr Val Cys Arg Gly Cys 
            260                 265                 270         


Pro Ser Gly Thr Phe Lys Ala Asn Gln Gly Asp Glu Ala Cys Thr His 
        275                 280                 285             


Cys Pro Ile Asn Ser Arg Thr Thr Ser Glu Gly Ala Thr Asn Cys Val 
    290                 295                 300                 


Cys Arg Asn Gly Tyr Tyr Arg Ala Asp Leu Asp Pro Leu Asp Met Pro 
305                 310                 315                 320 


Cys Thr Thr Ile Pro Ser Ala Pro Gln Ala Val Ile Ser Ser Val Asn 
                325                 330                 335     


Glu Thr Ser Leu Met Leu Glu Trp Thr Pro Pro Arg Asp Ser Gly Gly 
            340                 345                 350         


Arg Glu Asp Leu Val Tyr Asn Ile Ile Cys Lys Ser Cys Gly Ser Gly 
        355                 360                 365             


Arg Gly Ala Cys Thr Arg Cys Gly Asp Asn Val Gln Tyr Ala Pro Arg 
    370                 375                 380                 


Gln Leu Gly Leu Thr Glu Pro Arg Ile Tyr Ile Ser Asp Leu Leu Ala 
385                 390                 395                 400 


His Thr Gln Tyr Thr Phe Glu Ile Gln Ala Val Asn Gly Val Thr Asp 
                405                 410                 415     


Gln Ser Pro Phe Ser Pro Gln Phe Ala Ser Val Asn Ile Thr Thr Asn 
            420                 425                 430         


Gln Ala Ala Pro Ser Ala Val Ser Ile Met His Gln Val Ser Arg Thr 
        435                 440                 445             


Val Asp Ser Ile Thr Leu Ser Trp Ser Gln Pro Asp Gln Pro Asn Gly 
    450                 455                 460                 


Val Ile Leu Asp Tyr Glu Leu Gln Tyr Tyr Glu Lys Glu Leu Ser Glu 
465                 470                 475                 480 


Tyr Asn Ala Thr Ala Ile Lys Ser Pro Thr Asn Thr Val Thr Val Gln 
                485                 490                 495     


Gly Leu Lys Ala Gly Ala Ile Tyr Val Phe Gln Val Arg Ala Arg Thr 
            500                 505                 510         


Val Ala Gly Tyr Gly Arg Tyr Ser Gly Lys Met Tyr Phe Gln Thr Met 
        515                 520                 525             


Thr Glu Ala Glu Tyr Gln Thr Ser Ile Gln Glu Lys Leu Pro Leu Ile 
    530                 535                 540                 


Ile Gly Ser Ser Ala Ala Gly Leu Val Phe Leu Ile Ala Val Val Val 
545                 550                 555                 560 


Ile Ala Ile Val Cys Asn Arg Arg Gly Phe Glu Arg Ala Asp Ser Glu 
                565                 570                 575     


Tyr Thr Asp Lys Leu Gln His Tyr Thr Ser Gly His Met Thr Pro Gly 
            580                 585                 590         


Met Lys Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala 
        595                 600                 605             


Val Arg Glu Phe Ala Lys Glu Ile Asp Ile Ser Cys Val Lys Ile Glu 
    610                 615                 620                 


Gln Val Ile Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly His Leu 
625                 630                 635                 640 


Lys Leu Pro Gly Lys Arg Glu Ile Phe Val Ala Ile Lys Thr Leu Lys 
                645                 650                 655     


Ser Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser 
            660                 665                 670         


Ile Met Gly Gln Phe Asp His Pro Asn Val Ile His Leu Glu Gly Val 
        675                 680                 685             


Val Thr Lys Ser Thr Pro Val Met Ile Ile Thr Glu Phe Met Glu Asn 
    690                 695                 700                 


Gly Ser Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr Val 
705                 710                 715                 720 


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr 
                725                 730                 735     


Leu Ala Asp Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile 
            740                 745                 750         


Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser 
        755                 760                 765             


Arg Phe Leu Glu Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ala Leu 
    770                 775                 780                 


Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Gln Tyr 
785                 790                 795                 800 


Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met 
                805                 810                 815     


Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Thr Asn 
            820                 825                 830         


Gln Asp Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro 
        835                 840                 845             


Met Asp Cys Pro Ser Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln 
    850                 855                 860                 


Lys Asp Arg Asn His Arg Pro Lys Phe Gly Gln Ile Val Asn Thr Leu 
865                 870                 875                 880 


Asp Lys Met Ile Arg Asn Pro Asn Ser Leu Lys Ala Met Ala Pro Leu 
                885                 890                 895     


Ser Ser Gly Ile Asn Leu Pro Leu Leu Asp Arg Thr Ile Pro Asp Tyr 
            900                 905                 910         


Thr Ser Phe Asn Thr Val Asp Glu Trp Leu Glu Ala Ile Lys Met Gly 
        915                 920                 925             


Gln Tyr Lys Glu Ser Phe Ala Asn Ala Gly Phe Thr Ser Phe Asp Val 
    930                 935                 940                 


Val Ser Gln Met Met Met Glu Asp Ile Leu Arg Val Gly Val Thr Leu 
945                 950                 955                 960 


Ala Gly His Gln Lys Lys Ile Leu Asn Ser Ile Gln Val Met Arg Ala 
                965                 970                 975     


Gln Met Asn Gln Ile Gln Ser Val Glu Val 
            980                 985     


<210>  7
<211>  987
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Leu Arg Arg Leu Gly Ala Ala Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Ala Ala Val Glu Glu Thr Leu Met Asp Ser Thr Thr Ala Thr Ala Glu 
            20                  25                  30          


Leu Gly Trp Met Val His Pro Pro Ser Gly Trp Glu Glu Val Ser Gly 
        35                  40                  45              


Tyr Asp Glu Asn Met Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val 
    50                  55                  60                  


Phe Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Lys Phe Ile Arg Arg 
65                  70                  75                  80  


Arg Gly Ala His Arg Ile His Val Glu Met Lys Phe Ser Val Arg Asp 
                85                  90                  95      


Cys Ser Ser Ile Pro Ser Val Pro Gly Ser Cys Lys Glu Thr Phe Asn 
            100                 105                 110         


Leu Tyr Tyr Tyr Glu Ala Asp Phe Asp Ser Ala Thr Lys Thr Phe Pro 
        115                 120                 125             


Asn Trp Met Glu Asn Pro Trp Val Lys Val Asp Thr Ile Ala Ala Asp 
    130                 135                 140                 


Glu Ser Phe Ser Gln Val Asp Leu Gly Gly Arg Val Met Lys Ile Asn 
145                 150                 155                 160 


Thr Glu Val Arg Ser Phe Gly Pro Val Ser Arg Ser Gly Phe Tyr Leu 
                165                 170                 175     


Ala Phe Gln Asp Tyr Gly Gly Cys Met Ser Leu Ile Ala Val Arg Val 
            180                 185                 190         


Phe Tyr Arg Lys Cys Pro Arg Ile Ile Gln Asn Gly Ala Ile Phe Gln 
        195                 200                 205             


Glu Thr Leu Ser Gly Ala Glu Ser Thr Ser Leu Val Ala Ala Arg Gly 
    210                 215                 220                 


Ser Cys Ile Ala Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr 
225                 230                 235                 240 


Cys Asn Gly Asp Gly Glu Trp Leu Val Pro Ile Gly Arg Cys Met Cys 
                245                 250                 255     


Lys Ala Gly Phe Glu Ala Val Glu Asn Gly Thr Val Cys Arg Gly Cys 
            260                 265                 270         


Pro Ser Gly Thr Phe Lys Ala Asn Gln Gly Asp Glu Ala Cys Thr His 
        275                 280                 285             


Cys Pro Ile Asn Ser Arg Thr Thr Ser Glu Gly Ala Thr Asn Cys Val 
    290                 295                 300                 


Cys Arg Asn Gly Tyr Tyr Arg Ala Asp Leu Asp Pro Leu Asp Met Pro 
305                 310                 315                 320 


Cys Thr Thr Ile Pro Ser Ala Pro Gln Ala Val Ile Ser Ser Val Asn 
                325                 330                 335     


Glu Thr Ser Leu Met Leu Glu Trp Thr Pro Pro Arg Asp Ser Gly Gly 
            340                 345                 350         


Arg Glu Asp Leu Val Tyr Asn Ile Ile Cys Lys Ser Cys Gly Ser Gly 
        355                 360                 365             


Arg Gly Ala Cys Thr Arg Cys Gly Asp Asn Val Gln Tyr Ala Pro Arg 
    370                 375                 380                 


Gln Leu Gly Leu Thr Glu Pro Arg Ile Tyr Ile Ser Asp Leu Leu Ala 
385                 390                 395                 400 


His Thr Gln Tyr Thr Phe Glu Ile Gln Ala Val Asn Gly Val Thr Asp 
                405                 410                 415     


Gln Ser Pro Phe Ser Pro Gln Phe Ala Ser Val Asn Ile Thr Thr Asn 
            420                 425                 430         


Gln Ala Ala Pro Ser Ala Val Ser Ile Met His Gln Val Ser Arg Thr 
        435                 440                 445             


Val Asp Ser Ile Thr Leu Ser Trp Ser Gln Pro Asp Gln Pro Asn Gly 
    450                 455                 460                 


Val Ile Leu Asp Tyr Glu Leu Gln Tyr Tyr Glu Lys Glu Leu Ser Glu 
465                 470                 475                 480 


Tyr Asn Ala Thr Ala Ile Lys Ser Pro Thr Asn Thr Val Thr Val Gln 
                485                 490                 495     


Gly Leu Lys Ala Gly Ala Ile Tyr Val Phe Gln Val Arg Ala Arg Thr 
            500                 505                 510         


Val Ala Gly Tyr Gly Arg Tyr Ser Gly Lys Met Tyr Phe Gln Thr Met 
        515                 520                 525             


Thr Glu Ala Glu Tyr Gln Thr Ser Ile Gln Glu Lys Leu Pro Leu Ile 
    530                 535                 540                 


Ile Gly Ser Ser Ala Ala Gly Leu Val Phe Leu Ile Ala Val Val Val 
545                 550                 555                 560 


Ile Ala Ile Val Cys Asn Arg Arg Arg Gly Phe Glu Arg Ala Asp Ser 
                565                 570                 575     


Glu Tyr Thr Asp Lys Leu Gln His Tyr Thr Ser Gly His Met Thr Pro 
            580                 585                 590         


Gly Met Lys Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu 
        595                 600                 605             


Ala Val Arg Glu Phe Ala Lys Glu Ile Asp Ile Ser Cys Val Lys Ile 
    610                 615                 620                 


Glu Gln Val Ile Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly His 
625                 630                 635                 640 


Leu Lys Leu Pro Gly Lys Arg Glu Ile Phe Val Ala Ile Lys Thr Leu 
                645                 650                 655     


Lys Ser Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala 
            660                 665                 670         


Ser Ile Met Gly Gln Phe Asp His Pro Asn Val Ile His Leu Glu Gly 
        675                 680                 685             


Val Val Thr Lys Ser Thr Pro Val Met Ile Ile Thr Glu Phe Met Glu 
    690                 695                 700                 


Asn Gly Ser Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr 
705                 710                 715                 720 


Val Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys 
                725                 730                 735     


Tyr Leu Ala Asp Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn 
            740                 745                 750         


Ile Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu 
        755                 760                 765             


Ser Arg Phe Leu Glu Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ala 
    770                 775                 780                 


Leu Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Gln 
785                 790                 795                 800 


Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val 
                805                 810                 815     


Met Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Thr 
            820                 825                 830         


Asn Gln Asp Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro 
        835                 840                 845             


Pro Met Asp Cys Pro Ser Ala Leu His Gln Leu Met Leu Asp Cys Trp 
    850                 855                 860                 


Gln Lys Asp Arg Asn His Arg Pro Lys Phe Gly Gln Ile Val Asn Thr 
865                 870                 875                 880 


Leu Asp Lys Met Ile Arg Asn Pro Asn Ser Leu Lys Ala Met Ala Pro 
                885                 890                 895     


Leu Ser Ser Gly Ile Asn Leu Pro Leu Leu Asp Arg Thr Ile Pro Asp 
            900                 905                 910         


Tyr Thr Ser Phe Asn Thr Val Asp Glu Trp Leu Glu Ala Ile Lys Met 
        915                 920                 925             


Gly Gln Tyr Lys Glu Ser Phe Ala Asn Ala Gly Phe Thr Ser Phe Asp 
    930                 935                 940                 


Val Val Ser Gln Met Met Met Glu Asp Ile Leu Arg Val Gly Val Thr 
945                 950                 955                 960 


Leu Ala Gly His Gln Lys Lys Ile Leu Asn Ser Ile Gln Val Met Arg 
                965                 970                 975     


Ala Gln Met Asn Gln Ile Gln Ser Val Glu Val 
            980                 985         


<210>  8
<211>  1322
<212>  DNA
<213>  Mus musculus

<400>  8
gacacaccga agggaagtcc gggggcctct tccaccgagt ccgagtgacc ccgccccttg       60

cattctggaa ggtgaggcgc agaggtcccc agacacggac ctcaggcgca gggaggtccc      120

ctttctctga gcccaggacc ctcccacccc caggctcaca ttctttctct caggatcttc      180

aagcgggtct cttaagctcc ctcttcccca ggacgttgga gtcacagcct cagatctttc      240

tctccaatct cacaagtggg ccagaactcc tttataatgt ctggatcccc aacagcaagc      300

tctcccccac actaaaattc ggggatctag agctctgccc tagctttctc agcccctagc      360

tccatcctcc agcaagactc aagacagctc cggaaacacc tccttccccc agttccccag      420

acaacaagat ctcaggctcc tccctcggac ttcctcttag ttccaccctc ttcctcagag      480

gccaccatgg gacgcccccc accctgtgca atccagccgt ggatccttct gcttctgttc      540

atgggagcgt gggcagggct caccagagct cagggctcca agatcctgga aggtcgagag      600

tgtatacccc actcccagcc ttggcaggca gccttgttcc agggcgagag actgatctgt      660

gggggtgtcc tggttggaga cagatgggtc ctcacggcag cccactgcaa aaaacagaag      720

tactccgtgc gtctgggtga tcatagcctc cagagcagag atcagccgga gcaggagatc      780

caggtggctc agtctatcca gcatccttgc tacaacaaca gcaacccaga agatcacagt      840

cacgatataa tgctcattcg actgcagaac tcagcaaacc tcggggacaa ggtgaagccg      900

gtccaactgg ccaatctgtg tcccaaagtt ggccagaagt gcatcatatc aggctggggc      960

actgtcacca gccctcaaga gaactttcca aacaccctca actgtgcgga agtgaaaatc     1020

tattcccaga acaagtgtga gagagcctat ccagggaaga tcaccgaggg catggtctgt     1080

gctggcagca gcaatggagc tgacacgtgc cagggtgact caggaggccc tctggtgtgc     1140

gacgggatgc tccagggcat cacctcatgg ggctcagacc cctgtgggaa acccgagaaa     1200

cctggagtct acaccaaaat ctgccgctac actacctgga tcaagaagac catggacaac     1260

agggactgat cctggtgtgt gtgtgtgggg ggggttgtca ataaacacca ccattggctg     1320

gc                                                                    1322


<210>  9
<211>  1023
<212>  DNA
<213>  Homo sapiens

<400>  9
gttcccagaa gctccccagg ctctagtgca ggaggagaag gaggaggagc aggaggtgga       60

gattcccagt taaaaggctc cagaatcgtg taccaggcag agaactgaag tactggggcc      120

tcctccactg ggtccgaatc agtaggtgac cccgcccctg gattctggaa gacctcacca      180

tgggacgccc ccgacctcgt gcggccaaga cgtggatgtt cctgctcttg ctggggggag      240

cctgggcagg acactccagg gcacaggagg acaaggtgct ggggggtcat gagtgccaac      300

cccattcgca gccttggcag gcggccttgt tccagggcca gcaactactc tgtggcggtg      360

tccttgtagg tggcaactgg gtccttacag ctgcccactg taaaaaaccg aaatacacag      420

tacgcctggg agaccacagc ctacagaata aagatggccc agagcaagaa atacctgtgg      480

ttcagtccat cccacacccc tgctacaaca gcagcgatgt ggaggaccac aaccatgatc      540

tgatgcttct tcaactgcgt gaccaggcat ccctggggtc caaagtgaag cccatcagcc      600

tggcagatca ttgcacccag cctggccaga agtgcaccgt ctcaggctgg ggcactgtca      660

ccagtccccg agagaatttt cctgacactc tcaactgtgc agaagtaaaa atctttcccc      720

agaagaagtg tgaggatgct tacccggggc agatcacaga tggcatggtc tgtgcaggca      780

gcagcaaagg ggctgacacg tgccagggcg attctggagg ccccctggtg tgtgatggtg      840

cactccaggg catcacatcc tggggctcag acccctgtgg gaggtccgac aaacctggcg      900

tctataccaa catctgccgc tacctggact ggatcaagaa gatcataggc agcaagggct      960

gattctagga taagcactag atctccctta ataaactcac aactctctgg ttcaaaaaaa     1020

aaa                                                                   1023


<210>  10
<211>  1158
<212>  DNA
<213>  Homo sapiens

<400>  10
gttcccagaa gctccccagg ctctagtgca ggaggagaag gaggaggagc aggaggtgga       60

gattcccagt taaaaggctc cagaatcgtg taccaggcag agaactgaag tactggggcc      120

tcctccactg ggtccgaatc agtaggtgac cccgcccctg gattctggaa gacctcacca      180

tgggacgccc ccgacctcgt gcggccaaga cgtggatgtt cctgctcttg ctggggggag      240

cctgggcagc gtgtggaagc ctggacctcc tcactaagtt gtatgcggag aacttgccgt      300

gtgtccattt gaacccacag tggccttccc agccctcgca ctgccccaga gggtggcgat      360

ccaaccctct ccctcctgct gcaggacact ccagggcaca ggaggacaag gtgctggggg      420

gtcatgagtg ccaaccccat tcgcagcctt ggcaggcggc cttgttccag ggccagcaac      480

tactctgtgg cggtgtcctt gtaggtggca actgggtcct tacagctgcc cactgtaaaa      540

aaccgaaata cacagtacgc ctgggagacc acagcctaca gaataaagat ggcccagagc      600

aagaaatacc tgtggttcag tccatcccac acccctgcta caacagcagc gatgtggagg      660

accacaacca tgatctgatg cttcttcaac tgcgtgacca ggcatccctg gggtccaaag      720

tgaagcccat cagcctggca gatcattgca cccagcctgg ccagaagtgc accgtctcag      780

gctggggcac tgtcaccagt ccccgagaga attttcctga cactctcaac tgtgcagaag      840

taaaaatctt tccccagaag aagtgtgagg atgcttaccc ggggcagatc acagatggca      900

tggtctgtgc aggcagcagc aaaggggctg acacgtgcca gggcgattct ggaggccccc      960

tggtgtgtga tggtgcactc cagggcatca catcctgggg ctcagacccc tgtgggaggt     1020

ccgacaaacc tggcgtctat accaacatct gccgctacct ggactggatc aagaagatca     1080

taggcagcaa gggctgattc taggataagc actagatctc ccttaataaa ctcacaactc     1140

tctggttcaa aaaaaaaa                                                   1158


<210>  11
<211>  600
<212>  DNA
<213>  Homo sapiens

<400>  11
gttcccagaa gctccccagg ctctagtgca ggaggagaag gaggaggagc aggaggtgga       60

gattcccagt taaaaggctc cagaatcgtg taccaggcag agaactgaag tactggggcc      120

tcctccactg ggtccgaatc agtaggtgac cccgcccctg gattctggaa gacctcacca      180

tgggacgccc ccgacctcgt gcggccaaga cgtggatgtt cctgctcttg ctggggggag      240

cctgggcaga gaattttcct gacactctca actgtgcaga agtaaaaatc tttccccaga      300

agaagtgtga ggatgcttac ccggggcaga tcacagatgg catggtctgt gcaggcagca      360

gcaaaggggc tgacacgtgc cagggcgatt ctggaggccc cctggtgtgt gatggtgcac      420

tccagggcat cacatcctgg ggctcagacc cctgtgggag gtccgacaaa cctggcgtct      480

ataccaacat ctgccgctac ctggactgga tcaagaagat cataggcagc aagggctgat      540

tctaggataa gcactagatc tcccttaata aactcacaac tctctggttc aaaaaaaaaa      600


<210>  12
<211>  466
<212>  DNA
<213>  Homo sapiens

<400>  12
gttcccagaa gctccccagg ctctagtgca ggaggagaag gaggaggagc aggaggtgga       60

gattcccagt taaaaggctc cagaatcgtg taccaggcag agaactgaag tactggggcc      120

tcctccactg ggtccgaatc agtaggtgac cccgcccctg gattctggaa gacctcacca      180

tgggacgccc ccgacctcgt gcggccaaga cgtggatgtt cctgctcttg ctggggggag      240

cctgggcagg gcgattctgg aggccccctg gtgtgtgatg gtgcactcca gggcatcaca      300

tcctggggct cagacccctg tgggaggtcc gacaaacctg gcgtctatac caacatctgc      360

cgctacctgg actggatcaa gaagatcata ggcagcaagg gctgattcta ggataagcac      420

tagatctccc ttaataaact cacaactctc tggttcaaaa aaaaaa                     466


<210>  13
<211>  863
<212>  DNA
<213>  Homo sapiens

<400>  13
gttcccagaa gctccccagg ctctagtgca ggaggagaag gaggaggagc aggaggtgga       60

gattcccagt taaaaggctc cagaatcgtg taccaggcag agaactgaag tactggggcc      120

tcctccactg ggtccgaatc agtaggtgac cccgcccctg gattctggaa gacctcacca      180

tgggacgccc ccgacctcgt gcggccaaga cgtggatgtt cctgctcttg ctggggggag      240

cctgggcagg aaatacacag tacgcctggg agaccacagc ctacagaata aagatggccc      300

agagcaagaa atacctgtgg ttcagtccat cccacacccc tgctacaaca gcagcgatgt      360

ggaggaccac aaccatgatc tgatgcttct tcaactgcgt gaccaggcat ccctggggtc      420

caaagtgaag cccatcagcc tggcagatca ttgcacccag cctggccaga agtgcaccgt      480

ctcaggctgg ggcactgtca ccagtccccg agagaatttt cctgacactc tcaactgtgc      540

agaagtaaaa atctttcccc agaagaagtg tgaggatgct tacccggggc agatcacaga      600

tggcatggtc tgtgcaggca gcagcaaagg ggctgacacg tgccagggcg attctggagg      660

ccccctggtg tgtgatggtg cactccaggg catcacatcc tggggctcag acccctgtgg      720

gaggtccgac aaacctggcg tctataccaa catctgccgc tacctggact ggatcaagaa      780

gatcataggc agcaagggct gattctagga taagcactag atctccctta ataaactcac      840

aactctctgg ttcaaaaaaa aaa                                              863


