                         SEQUENCE LISTING

<110>  Anara AB
 
<120>  AMYLASE FRAGMENTS FOR BLOOD GLUCOSE CONTROL

<130>  NP0224WO

<150>  1551220-5
<151>  2015-09-23

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  499
<212>  PRT
<213>  Aspergillus oryzae

<400>  1

Met Met Val Ala Trp Trp Ser Leu Phe Leu Tyr Gly Leu Gln Val Ala 
1               5                   10                  15      


Ala Pro Ala Leu Ala Ala Thr Pro Ala Asp Trp Arg Ser Gln Ser Ile 
            20                  25                  30          


Tyr Phe Leu Leu Thr Asp Arg Phe Ala Arg Thr Asp Gly Ser Thr Thr 
        35                  40                  45              


Ala Thr Cys Asn Thr Ala Asp Arg Lys Tyr Cys Gly Gly Thr Trp Gln 
    50                  55                  60                  


Gly Ile Ile Asp Lys Leu Asp Tyr Ile Gln Gly Met Gly Phe Thr Ala 
65                  70                  75                  80  


Ile Trp Ile Thr Pro Val Thr Ala Gln Leu Pro Gln Thr Thr Ala Tyr 
                85                  90                  95      


Gly Asp Ala Tyr His Gly Tyr Trp Gln Gln Asp Ile Tyr Ser Leu Asn 
            100                 105                 110         


Glu Asn Tyr Gly Thr Ala Asp Asp Leu Lys Ala Leu Ser Ser Ala Leu 
        115                 120                 125             


His Glu Arg Gly Met Tyr Leu Met Val Asp Val Val Ala Asn His Met 
    130                 135                 140                 


Gly Tyr Asp Gly Ala Gly Ser Ser Val Asp Tyr Ser Val Phe Lys Pro 
145                 150                 155                 160 


Phe Ser Ser Gln Asp Tyr Phe His Pro Phe Cys Leu Ile Gln Asn Tyr 
                165                 170                 175     


Glu Asp Gln Thr Gln Val Glu Asp Cys Trp Leu Gly Asp Asn Thr Val 
            180                 185                 190         


Ser Leu Pro Asp Leu Asp Thr Thr Lys Asp Val Val Lys Asn Glu Trp 
        195                 200                 205             


Tyr Asp Trp Val Gly Ser Leu Val Ser Asn Tyr Ser Ile Asp Gly Leu 
    210                 215                 220                 


Arg Ile Asp Thr Val Lys His Val Gln Lys Asp Phe Trp Pro Gly Tyr 
225                 230                 235                 240 


Asn Lys Ala Ala Gly Val Tyr Cys Ile Gly Glu Val Leu Asp Gly Asp 
                245                 250                 255     


Pro Ala Tyr Thr Cys Pro Tyr Gln Asn Val Met Asp Gly Val Leu Asn 
            260                 265                 270         


Tyr Pro Ile Tyr Tyr Pro Leu Leu Asn Ala Phe Lys Ser Thr Ser Gly 
        275                 280                 285             


Ser Met Asp Asp Leu Tyr Asn Met Ile Asn Thr Val Lys Ser Asp Cys 
    290                 295                 300                 


Pro Asp Ser Thr Leu Leu Gly Thr Phe Val Glu Asn His Asp Asn Pro 
305                 310                 315                 320 


Arg Phe Ala Ser Tyr Thr Asn Asp Ile Ala Leu Ala Lys Asn Val Ala 
                325                 330                 335     


Ala Phe Ile Ile Leu Asn Asp Gly Ile Pro Ile Ile Tyr Ala Gly Gln 
            340                 345                 350         


Glu Gln His Tyr Ala Gly Gly Asn Asp Pro Ala Asn Arg Glu Ala Thr 
        355                 360                 365             


Trp Leu Ser Gly Tyr Pro Thr Asp Ser Glu Leu Tyr Lys Leu Ile Ala 
    370                 375                 380                 


Ser Ala Asn Ala Ile Arg Asn Tyr Ala Ile Ser Lys Asp Thr Gly Phe 
385                 390                 395                 400 


Val Thr Tyr Lys Asn Trp Pro Ile Tyr Lys Asp Asp Thr Thr Ile Ala 
                405                 410                 415     


Met Arg Lys Gly Thr Asp Gly Ser Gln Ile Val Thr Ile Leu Ser Asn 
            420                 425                 430         


Lys Gly Ala Ser Gly Asp Ser Tyr Thr Leu Ser Leu Ser Gly Ala Gly 
        435                 440                 445             


Tyr Thr Ala Gly Gln Gln Leu Thr Glu Val Ile Gly Cys Thr Thr Val 
    450                 455                 460                 


Thr Val Gly Ser Asp Gly Asn Val Pro Val Pro Met Ala Gly Gly Leu 
465                 470                 475                 480 


Pro Arg Val Leu Tyr Pro Thr Glu Lys Leu Ala Gly Ser Lys Ile Cys 
                485                 490                 495     


Ser Ser Ser 
            


<210>  2
<211>  28
<212>  PRT
<213>  Aspergillus oryzae

<400>  2

Met Met Val Ala Trp Trp Ser Leu Phe Leu Tyr Gly Leu Gln Val Ala 
1               5                   10                  15      


Ala Pro Ala Leu Ala Ala Thr Pro Ala Asp Trp Arg 
            20                  25              


<210>  3
<211>  11
<212>  PRT
<213>  Aspergillus oryzae

<400>  3

Ser Gln Ser Ile Tyr Phe Leu Leu Thr Asp Arg 
1               5                   10      


<210>  4
<211>  14
<212>  PRT
<213>  Aspergillus oryzae

<400>  4

Thr Asp Gly Ser Thr Thr Ala Thr Cys Asn Thr Ala Asp Arg 
1               5                   10                  


<210>  5
<211>  12
<212>  PRT
<213>  Aspergillus oryzae

<400>  5

Tyr Cys Gly Gly Thr Trp Gln Gly Ile Ile Asp Lys 
1               5                   10          


<210>  6
<211>  53
<212>  PRT
<213>  Aspergillus oryzae

<400>  6

Leu Asp Tyr Ile Gln Gly Met Gly Phe Thr Ala Ile Trp Ile Thr Pro 
1               5                   10                  15      


Val Thr Ala Gln Leu Pro Gln Thr Thr Ala Tyr Gly Asp Ala Tyr His 
            20                  25                  30          


Gly Tyr Trp Gln Gln Asp Ile Tyr Ser Leu Asn Glu Asn Tyr Gly Thr 
        35                  40                  45              


Ala Asp Asp Leu Lys 
    50              


<210>  7
<211>  9
<212>  PRT
<213>  Aspergillus oryzae

<400>  7

Ala Leu Ser Ser Ala Leu His Glu Arg 
1               5                   


<210>  8
<211>  70
<212>  PRT
<213>  Aspergillus oryzae

<400>  8

Gly Met Tyr Leu Met Val Asp Val Val Ala Asn His Met Gly Tyr Asp 
1               5                   10                  15      


Gly Ala Gly Ser Ser Val Asp Tyr Ser Val Phe Lys Pro Phe Ser Ser 
            20                  25                  30          


Gln Asp Tyr Phe His Pro Phe Cys Leu Ile Gln Asn Tyr Glu Asp Gln 
        35                  40                  45              


Thr Gln Val Glu Asp Cys Trp Leu Gly Asp Asn Thr Val Ser Leu Pro 
    50                  55                  60                  


Asp Leu Asp Thr Thr Lys 
65                  70  


<210>  9
<211>  4
<212>  PRT
<213>  Aspergillus oryzae

<400>  9

Asp Val Val Lys 
1               


<210>  10
<211>  20
<212>  PRT
<213>  Aspergillus oryzae

<400>  10

Asn Glu Trp Tyr Asp Trp Val Gly Ser Leu Val Ser Asn Tyr Ser Ile 
1               5                   10                  15      


Asp Gly Leu Arg 
            20  


<210>  11
<211>  5
<212>  PRT
<213>  Aspergillus oryzae

<400>  11

Ile Asp Thr Val Lys 
1               5   


<210>  12
<211>  4
<212>  PRT
<213>  Aspergillus oryzae

<400>  12

His Val Gln Lys 
1               


<210>  13
<211>  8
<212>  PRT
<213>  Aspergillus oryzae

<400>  13

Asp Phe Trp Pro Gly Tyr Asn Lys 
1               5               


<210>  14
<211>  42
<212>  PRT
<213>  Aspergillus oryzae

<400>  14

Ala Ala Gly Val Tyr Cys Ile Gly Glu Val Leu Asp Gly Asp Pro Ala 
1               5                   10                  15      


Tyr Thr Cys Pro Tyr Gln Asn Val Met Asp Gly Val Leu Asn Tyr Pro 
            20                  25                  30          


Ile Tyr Tyr Pro Leu Leu Asn Ala Phe Lys 
        35                  40          


<210>  15
<211>  17
<212>  PRT
<213>  Aspergillus oryzae

<400>  15

Ser Thr Ser Gly Ser Met Asp Asp Leu Tyr Asn Met Ile Asn Thr Val 
1               5                   10                  15      


Lys 
    


<210>  16
<211>  20
<212>  PRT
<213>  Aspergillus oryzae

<400>  16

Ser Asp Cys Pro Asp Ser Thr Leu Leu Gly Thr Phe Val Glu Asn His 
1               5                   10                  15      


Asp Asn Pro Arg 
            20  


<210>  17
<211>  12
<212>  PRT
<213>  Aspergillus oryzae

<400>  17

Phe Ala Ser Tyr Thr Asn Asp Ile Ala Leu Ala Lys 
1               5                   10          


<210>  18
<211>  32
<212>  PRT
<213>  Aspergillus oryzae

<400>  18

Asn Val Ala Ala Phe Ile Ile Leu Asn Asp Gly Ile Pro Ile Ile Tyr 
1               5                   10                  15      


Ala Gly Gln Glu Gln His Tyr Ala Gly Gly Asn Asp Pro Ala Asn Arg 
            20                  25                  30          


<210>  19
<211>  16
<212>  PRT
<213>  Aspergillus oryzae

<400>  19

Glu Ala Thr Trp Leu Ser Gly Tyr Pro Thr Asp Ser Glu Leu Tyr Lys 
1               5                   10                  15      


<210>  20
<211>  9
<212>  PRT
<213>  Aspergillus oryzae

<400>  20

Leu Ile Ala Ser Ala Asn Ala Ile Arg 
1               5                   


<210>  21
<211>  6
<212>  PRT
<213>  Aspergillus oryzae

<400>  21

Asn Tyr Ala Ile Ser Lys 
1               5       


<210>  22
<211>  8
<212>  PRT
<213>  Aspergillus oryzae

<400>  22

Asp Thr Gly Phe Val Thr Tyr Lys 
1               5               


<210>  23
<211>  6
<212>  PRT
<213>  Aspergillus oryzae

<400>  23

Asn Trp Pro Ile Tyr Lys 
1               5       


<210>  24
<211>  8
<212>  PRT
<213>  Aspergillus oryzae

<400>  24

Asp Asp Thr Thr Ile Ala Met Arg 
1               5               


<210>  25
<211>  14
<212>  PRT
<213>  Aspergillus oryzae

<400>  25

Gly Thr Asp Gly Ser Gln Ile Val Thr Ile Leu Ser Asn Lys 
1               5                   10                  


<210>  26
<211>  49
<212>  PRT
<213>  Aspergillus oryzae

<400>  26

Gly Ala Ser Gly Asp Ser Tyr Thr Leu Ser Leu Ser Gly Ala Gly Tyr 
1               5                   10                  15      


Thr Ala Gly Gln Gln Leu Thr Glu Val Ile Gly Cys Thr Thr Val Thr 
            20                  25                  30          


Val Gly Ser Asp Gly Asn Val Pro Val Pro Met Ala Gly Gly Leu Pro 
        35                  40                  45              


Arg 
    


<210>  27
<211>  7
<212>  PRT
<213>  Aspergillus oryzae

<400>  27

Val Leu Tyr Pro Thr Glu Lys 
1               5           


<210>  28
<211>  5
<212>  PRT
<213>  Aspergillus oryzae

<400>  28

Leu Ala Gly Ser Lys 
1               5   


<210>  29
<211>  5
<212>  PRT
<213>  Aspergillus oryzae

<400>  29

Ile Cys Ser Ser Ser 
1               5   


<210>  30
<211>  511
<212>  PRT
<213>  Sus scrofa

<400>  30

Met Lys Leu Phe Leu Leu Leu Ser Ala Phe Gly Phe Cys Trp Ala Gln 
1               5                   10                  15      


Tyr Ala Pro Gln Thr Gln Ser Gly Arg Thr Ser Ile Val His Leu Phe 
            20                  25                  30          


Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu Gly 
        35                  40                  45              


Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn Ile 
    50                  55                  60                  


Val Val Thr Asn Pro Ser Arg Pro Trp Trp Glu Arg Tyr Gln Pro Val 
65                  70                  75                  80  


Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asn Glu Phe Arg Asp 
                85                  90                  95      


Met Val Thr Arg Cys Asn Asn Val Gly Val Arg Ile Tyr Val Asp Ala 
            100                 105                 110         


Val Ile Asn His Met Cys Gly Ser Gly Ala Ala Ala Gly Thr Gly Thr 
        115                 120                 125             


Thr Cys Gly Ser Tyr Cys Asn Pro Gly Asn Arg Glu Phe Pro Ala Val 
    130                 135                 140                 


Pro Tyr Ser Ala Trp Asp Phe Asn Asp Gly Lys Cys Lys Thr Ala Ser 
145                 150                 155                 160 


Gly Gly Ile Glu Ser Tyr Asn Asp Pro Tyr Gln Val Arg Asp Cys Gln 
                165                 170                 175     


Leu Val Gly Leu Leu Asp Leu Ala Leu Glu Lys Asp Tyr Val Arg Ser 
            180                 185                 190         


Met Ile Ala Asp Tyr Leu Asn Lys Leu Ile Asp Ile Gly Val Ala Gly 
        195                 200                 205             


Phe Arg Ile Asp Ala Ser Lys His Met Trp Pro Gly Asp Ile Lys Ala 
    210                 215                 220                 


Val Leu Asp Lys Leu His Asn Leu Asn Thr Asn Trp Phe Pro Ala Gly 
225                 230                 235                 240 


Ser Arg Pro Phe Ile Phe Gln Glu Val Ile Asp Leu Gly Gly Glu Ala 
                245                 250                 255     


Ile Gln Ser Ser Glu Tyr Phe Gly Asn Gly Arg Val Thr Glu Phe Lys 
            260                 265                 270         


Tyr Gly Ala Lys Leu Gly Thr Val Val Arg Lys Trp Ser Gly Glu Lys 
        275                 280                 285             


Met Ser Tyr Leu Lys Asn Trp Gly Glu Gly Trp Gly Phe Met Pro Ser 
    290                 295                 300                 


Asp Arg Ala Leu Val Phe Val Asp Asn His Asp Asn Gln Arg Gly His 
305                 310                 315                 320 


Gly Ala Gly Gly Ala Ser Ile Leu Thr Phe Trp Asp Ala Arg Leu Tyr 
                325                 330                 335     


Lys Val Ala Val Gly Phe Met Leu Ala His Pro Tyr Gly Phe Thr Arg 
            340                 345                 350         


Val Met Ser Ser Tyr Arg Trp Ala Arg Asn Phe Val Asn Gly Gln Asp 
        355                 360                 365             


Val Asn Asp Trp Ile Gly Pro Pro Asn Asn Asn Gly Val Ile Lys Glu 
    370                 375                 380                 


Val Thr Ile Asn Ala Asp Thr Thr Cys Gly Asn Asp Trp Val Cys Glu 
385                 390                 395                 400 


His Arg Trp Arg Gln Ile Arg Asn Met Val Trp Phe Arg Asn Val Val 
                405                 410                 415     


Asp Gly Gln Pro Phe Ala Asn Trp Trp Ala Asn Gly Ser Asn Gln Val 
            420                 425                 430         


Ala Phe Gly Arg Gly Asn Arg Gly Phe Ile Val Phe Asn Asn Asp Asp 
        435                 440                 445             


Trp Gln Leu Ser Ser Thr Leu Gln Thr Gly Leu Pro Gly Gly Thr Tyr 
    450                 455                 460                 


Cys Asp Val Ile Ser Gly Asp Lys Val Gly Asn Ser Cys Thr Gly Ile 
465                 470                 475                 480 


Lys Val Tyr Val Ser Ser Asp Gly Thr Ala Gln Phe Ser Ile Ser Asn 
                485                 490                 495     


Ser Ala Glu Asp Pro Phe Ile Ala Ile His Ala Glu Ser Lys Leu 
            500                 505                 510     


<210>  31
<211>  511
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Lys Leu Phe Trp Leu Leu Phe Thr Ile Gly Phe Cys Trp Ala Gln 
1               5                   10                  15      


Tyr Ser Ser Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu Phe 
            20                  25                  30          


Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu Ala 
        35                  40                  45              


Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn Val 
    50                  55                  60                  


Ala Ile His Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro Val 
65                  70                  75                  80  


Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg Asn 
                85                  90                  95      


Met Val Thr Arg Cys Asn Asn Val Gly Val Arg Ile Tyr Val Asp Ala 
            100                 105                 110         


Val Ile Asn His Met Cys Gly Asn Ala Val Ser Ala Gly Thr Ser Ser 
        115                 120                 125             


Thr Cys Gly Ser Tyr Phe Asn Pro Gly Ser Arg Asp Phe Pro Ala Val 
    130                 135                 140                 


Pro Tyr Ser Gly Trp Asp Phe Asn Asp Gly Lys Cys Lys Thr Gly Ser 
145                 150                 155                 160 


Gly Asp Ile Glu Asn Tyr Asn Asp Ala Thr Gln Val Arg Asp Cys Arg 
                165                 170                 175     


Leu Ser Gly Leu Leu Asp Leu Ala Leu Gly Lys Asp Tyr Val Arg Ser 
            180                 185                 190         


Lys Ile Ala Glu Tyr Met Asn His Leu Ile Asp Ile Gly Val Ala Gly 
        195                 200                 205             


Phe Arg Ile Asp Ala Ser Lys His Met Trp Pro Gly Asp Ile Lys Ala 
    210                 215                 220                 


Ile Leu Asp Lys Leu His Asn Leu Asn Ser Asn Trp Phe Pro Glu Gly 
225                 230                 235                 240 


Ser Lys Pro Phe Ile Tyr Gln Glu Val Ile Asp Leu Gly Gly Glu Pro 
                245                 250                 255     


Ile Lys Ser Ser Asp Tyr Phe Gly Asn Gly Arg Val Thr Glu Phe Lys 
            260                 265                 270         


Tyr Gly Ala Lys Leu Gly Thr Val Ile Arg Lys Trp Asn Gly Glu Lys 
        275                 280                 285             


Met Ser Tyr Leu Lys Asn Trp Gly Glu Gly Trp Gly Phe Met Pro Ser 
    290                 295                 300                 


Asp Arg Ala Leu Val Phe Val Asp Asn His Asp Asn Gln Arg Gly His 
305                 310                 315                 320 


Gly Ala Gly Gly Ala Ser Ile Leu Thr Phe Trp Asp Ala Arg Leu Tyr 
                325                 330                 335     


Lys Met Ala Val Gly Phe Met Leu Ala His Pro Tyr Gly Phe Thr Arg 
            340                 345                 350         


Val Met Ser Ser Tyr Arg Trp Pro Arg Tyr Phe Glu Asn Gly Lys Asp 
        355                 360                 365             


Val Asn Asp Trp Val Gly Pro Pro Asn Asp Asn Gly Val Thr Lys Glu 
    370                 375                 380                 


Val Thr Ile Asn Pro Asp Thr Thr Cys Gly Asn Asp Trp Val Cys Glu 
385                 390                 395                 400 


His Arg Trp Arg Gln Ile Arg Asn Met Val Asn Phe Arg Asn Val Val 
                405                 410                 415     


Asp Gly Gln Pro Phe Thr Asn Trp Tyr Asp Asn Gly Ser Asn Gln Val 
            420                 425                 430         


Ala Phe Gly Arg Gly Asn Arg Gly Phe Ile Val Phe Asn Asn Asp Asp 
        435                 440                 445             


Trp Thr Phe Ser Leu Thr Leu Gln Thr Gly Leu Pro Ala Gly Thr Tyr 
    450                 455                 460                 


Cys Asp Val Ile Ser Gly Asp Lys Ile Asn Gly Asn Cys Thr Gly Ile 
465                 470                 475                 480 


Lys Ile Tyr Val Ser Asp Asp Gly Lys Ala His Phe Ser Ile Ser Asn 
                485                 490                 495     


Ser Ala Glu Asp Pro Phe Ile Ala Ile His Ala Glu Ser Lys Leu 
            500                 505                 510     


<210>  32
<211>  406
<212>  PRT
<213>  Vulcanisaeta distributa

<400>  32

Met Val Arg Lys Met Ile Leu Phe Leu Glu Met His Gln Pro Arg Arg 
1               5                   10                  15      


Leu Arg Tyr Gly Val Leu Asp Lys Leu Cys Asp Leu Arg Gly Asp Glu 
            20                  25                  30          


Val Asn Glu Ser Thr Ile Thr Ser Ile Ile Phe Asn Asp Glu Val Asn 
        35                  40                  45              


Arg Glu Ile Leu Asn Arg Val Ala Asp Arg Ser Tyr Ile Pro Thr Leu 
    50                  55                  60                  


Glu Leu Met Lys Asp Leu Gly Asn Asp Gly Phe Arg Ala Ala Ile Ser 
65                  70                  75                  80  


Ile Ser Gly Ser Leu Ile Asp Gln Leu Leu Met Trp Arg Pro Glu Val 
                85                  90                  95      


Ile Asp Leu Leu Lys Glu Leu Val Lys Arg Asp Val Ile Glu Leu Val 
            100                 105                 110         


Thr Glu Pro Tyr His His Ser Leu Ala Ser Phe Val Ser Gly Asp Leu 
        115                 120                 125             


Phe Leu Glu Glu Leu Arg Asp His Val Glu Met Asn Lys Ser Leu Phe 
    130                 135                 140                 


Gly Gln Thr Pro Ile Val Phe Glu Asn Thr Glu Phe Leu Tyr Arg Asn 
145                 150                 155                 160 


Asp Trp Gly Ile Leu Met Glu Lys Ala Gly Ala Ser Val Val Leu Thr 
                165                 170                 175     


Glu Gly Val Asp Trp Val Leu Gly Trp Arg Ser Pro Thr Tyr Leu Tyr 
            180                 185                 190         


Gly Ala Pro Asn Ser Arg Ile Lys Leu Leu Leu Arg His Tyr Arg Leu 
        195                 200                 205             


Ser Asp Asp Ile Gly Phe Arg Phe Ser Asn Arg Ser Trp Asp Gln Trp 
    210                 215                 220                 


Pro Leu Thr Ala Asp Lys Tyr Met Ala Trp Val Arg Ala Thr Pro Gly 
225                 230                 235                 240 


Asp Phe Val Leu Val Gly Leu Asp Phe Glu Thr Phe Gly Glu His His 
                245                 250                 255     


Trp Arg Glu Ser Gly Ile Phe Glu Phe Leu Ala Trp Leu Pro Lys Glu 
            260                 265                 270         


Ala Arg Arg Ala Asp Val Glu Phe Val His Pro Ser Ser Leu Ala Asn 
        275                 280                 285             


Glu Glu Pro Ile Asp Tyr Leu Asp Ile Pro Ser Val Ile Ser Trp Ala 
    290                 295                 300                 


Asp Val Glu Lys Asp Gly Ser Ala Trp Gln Gly Asn Asp Leu Gln Arg 
305                 310                 315                 320 


Ile Ala Leu Asn His Val Val Ser Ile Gly Asn Leu Met Arg Ser His 
                325                 330                 335     


Gly Leu Glu Lys Thr Trp Lys Tyr Leu Leu Thr Ser Asp His Tyr Tyr 
            340                 345                 350         


Tyr Met Ser Met Lys His Gly Pro Ser Gly Glu Val His Ser Tyr Phe 
        355                 360                 365             


Asn Pro Tyr Asn Ser Ala Leu Ala Ala Phe Arg Ala Ile Glu Asp Val 
    370                 375                 380                 


Val Val Gly Ile Thr Cys Ala Leu Ala Asn Val Gly Met Lys Arg Val 
385                 390                 395                 400 


Lys Ser Arg Ala Val Lys 
                405     


<210>  33
<211>  514
<212>  PRT
<213>  Desulfurococcus fermentans

<400>  33

Met Thr Asp Ile Val Leu Met Phe Glu Val His Gln Pro Tyr Arg Leu 
1               5                   10                  15      


Arg Arg Asn Leu His Ser Ile Leu Leu Glu Lys Ala Leu Ser Gly Arg 
            20                  25                  30          


Leu Glu Leu Lys Asp Leu Glu Asp Ile Val Phe Asp Asn Glu Leu Asn 
        35                  40                  45              


Arg Leu Val Ile Glu Arg Ala Ala Asp Arg Cys Tyr Val Pro Ala Thr 
    50                  55                  60                  


Gln Ile Ile Leu Glu Asn Val Lys Arg Tyr Met Asn Thr Ser Lys Glu 
65                  70                  75                  80  


Phe Lys Ala Ser Phe Ser Ile Ser Gly Val Phe Ile Glu Gln Ala Glu 
                85                  90                  95      


Lys Trp Arg Ser Asp Val Leu Asp Leu Phe Arg Lys Leu Ala Glu Thr 
            100                 105                 110         


Gly Arg Ile Glu Phe Ile Glu Gln Thr Tyr Tyr His Ser Met Ala Ala 
        115                 120                 125             


Phe Leu Pro Tyr Tyr Gly Phe Glu Glu Leu Arg Glu Gln Ile Arg Glu 
    130                 135                 140                 


His Arg Arg Ile Ile Glu Glu Thr Ile Gly Phe Lys Pro Val Ser Ile 
145                 150                 155                 160 


Glu Asn Thr Glu Phe Thr Tyr Asn Asn Asp Ile Ala Cys Phe Phe Asp 
                165                 170                 175     


Ser Glu Gly Tyr Lys Ala Val Leu Thr Glu Gly Ala Asp Arg Val Leu 
            180                 185                 190         


Gly Trp Arg Ser Pro Asn Tyr Val Tyr Lys Ala Tyr Gly Cys Asn Ile 
        195                 200                 205             


Arg Val Leu Thr Arg Asn Tyr Arg Leu Ser Asp Asp Val Gly Phe Arg 
    210                 215                 220                 


Phe Ser Asp Arg Lys Trp Asp Gln Tyr Pro Leu Thr Ala Asp Lys Tyr 
225                 230                 235                 240 


Ala Ser Trp Leu Ala Ser Thr Pro Gly Asp Val Ile Phe Ile Ala Val 
                245                 250                 255     


Asp Tyr Glu Thr Phe Gly Glu His His Trp Pro Glu Thr Gly Ile His 
            260                 265                 270         


Glu Phe Leu Arg Trp Leu Pro Gly Glu Val Leu Lys Tyr Gly His Leu 
        275                 280                 285             


Tyr Phe Ser Thr Pro Gly Glu Val Val Glu Arg His Pro Val Arg Asp 
    290                 295                 300                 


Val Ile Asp Val Pro Pro Trp Ser Ser Ile Ser Trp Ala Asp Glu Arg 
305                 310                 315                 320 


Asp Leu Ser Ala Trp Leu Gly Asn Gly Ile Gln Arg Glu Ala Tyr Asn 
                325                 330                 335     


Ala Leu Ala Ala Ile Arg Pro Phe Ile Lys Ala Val Asn Lys Pro Glu 
            340                 345                 350         


Ile Thr Arg Leu Trp Lys Leu Leu Thr Ile Ser Asp His Val Tyr Tyr 
        355                 360                 365             


Met Ala Thr Lys Phe Gly Ser Ile Gly Glu Val His Ser Tyr Phe Ser 
    370                 375                 380                 


Pro Tyr Lys Asn Ala Asn Ile Ala Tyr Gly Leu Phe Met Glu Ala Leu 
385                 390                 395                 400 


Gly Val Leu Val Glu Ala Val Arg Arg Glu Ile Glu Val Asn Arg Lys 
                405                 410                 415     


Ser Val Leu Gly Arg Leu Val Leu Pro Gly Asn Lys Ala Phe His Phe 
            420                 425                 430         


Thr Leu Pro Thr Gly Glu His Thr Gly Leu Val Ala His Ser Ile Arg 
        435                 440                 445             


Glu Phe Ile Glu Val Ile Glu Lys Val Pro Pro Glu Ser Leu Leu Tyr 
    450                 455                 460                 


His Phe Asn Lys Gly Asp Ile Asp Ala Trp Leu Leu Asn Ile Phe Gly 
465                 470                 475                 480 


Leu Gly Asp Ala Val Glu Glu Leu Arg Arg Leu Arg Glu Asn Ile Val 
                485                 490                 495     


Ser Tyr Ser Glu Leu Ile Ser Thr Leu Lys Lys Leu Leu Leu Glu Ile 
            500                 505                 510         


Ile Glu 
        


<210>  34
<211>  511
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Lys Phe Phe Leu Leu Leu Phe Thr Ile Gly Phe Cys Trp Ala Gln 
1               5                   10                  15      


Tyr Ser Pro Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu Phe 
            20                  25                  30          


Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu Ala 
        35                  40                  45              


Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn Val 
    50                  55                  60                  


Ala Ile Tyr Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro Val 
65                  70                  75                  80  


Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg Asn 
                85                  90                  95      


Met Val Thr Arg Cys Asn Asn Val Gly Val Arg Ile Tyr Val Asp Ala 
            100                 105                 110         


Val Ile Asn His Met Cys Gly Asn Ala Val Ser Ala Gly Thr Ser Ser 
        115                 120                 125             


Thr Cys Gly Ser Tyr Phe Asn Pro Gly Ser Arg Asp Phe Pro Ala Val 
    130                 135                 140                 


Pro Tyr Ser Gly Trp Asp Phe Asn Asp Gly Lys Cys Lys Thr Gly Ser 
145                 150                 155                 160 


Gly Asp Ile Glu Asn Tyr Asn Asp Ala Thr Gln Val Arg Asp Cys Arg 
                165                 170                 175     


Leu Thr Gly Leu Leu Asp Leu Ala Leu Glu Lys Asp Tyr Val Arg Ser 
            180                 185                 190         


Lys Ile Ala Glu Tyr Met Asn His Leu Ile Asp Ile Gly Val Ala Gly 
        195                 200                 205             


Phe Arg Leu Asp Ala Ser Lys His Met Trp Pro Gly Asp Ile Lys Ala 
    210                 215                 220                 


Ile Leu Asp Lys Leu His Asn Leu Asn Ser Asn Trp Phe Pro Ala Gly 
225                 230                 235                 240 


Ser Lys Pro Phe Ile Tyr Gln Glu Val Ile Asp Leu Gly Gly Glu Pro 
                245                 250                 255     


Ile Lys Ser Ser Asp Tyr Phe Gly Asn Gly Arg Val Thr Glu Phe Lys 
            260                 265                 270         


Tyr Gly Ala Lys Leu Gly Thr Val Ile Arg Lys Trp Asn Gly Glu Lys 
        275                 280                 285             


Met Ser Tyr Leu Lys Asn Trp Gly Glu Gly Trp Gly Phe Val Pro Ser 
    290                 295                 300                 


Asp Arg Ala Leu Val Phe Val Asp Asn His Asp Asn Gln Arg Gly His 
305                 310                 315                 320 


Gly Ala Gly Gly Ala Ser Ile Leu Thr Phe Trp Asp Ala Arg Leu Tyr 
                325                 330                 335     


Lys Met Ala Val Gly Phe Met Leu Ala His Pro Tyr Gly Phe Thr Arg 
            340                 345                 350         


Val Met Ser Ser Tyr Arg Trp Pro Arg Gln Phe Gln Asn Gly Asn Asp 
        355                 360                 365             


Val Asn Asp Trp Val Gly Pro Pro Asn Asn Asn Gly Val Ile Lys Glu 
    370                 375                 380                 


Val Thr Ile Asn Pro Asp Thr Thr Cys Gly Asn Asp Trp Val Cys Glu 
385                 390                 395                 400 


His Arg Trp Arg Gln Ile Arg Asn Met Val Ile Phe Arg Asn Val Val 
                405                 410                 415     


Asp Gly Gln Pro Phe Thr Asn Trp Tyr Asp Asn Gly Ser Asn Gln Val 
            420                 425                 430         


Ala Phe Gly Arg Gly Asn Arg Gly Phe Ile Val Phe Asn Asn Asp Asp 
        435                 440                 445             


Trp Ser Phe Ser Leu Thr Leu Gln Thr Gly Leu Pro Ala Gly Thr Tyr 
    450                 455                 460                 


Cys Asp Val Ile Ser Gly Asp Lys Ile Asn Gly Asn Cys Thr Gly Ile 
465                 470                 475                 480 


Lys Ile Tyr Val Ser Asp Asp Gly Lys Ala His Phe Ser Ile Ser Asn 
                485                 490                 495     


Ser Ala Glu Asp Pro Phe Ile Ala Ile His Ala Glu Ser Lys Leu 
            500                 505                 510     


