                         SEQUENCE LISTING

<110>  The University of North Carolina at Chapel Hill
       Huang, Leaf
       Goodwin, Tyler
       Liu, Rihe
 
<120>  METHODS AND COMPOSITIONS FOR REDUCING METASTASES

<130>  035052/482902

<150>  62/232,169
<151>  2015-09-24

<160>  66    

<170>  PatentIn version 3.5

<210>  1
<211>  175
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CXCL12-Trap-hSDA-1

<400>  1

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Gly Ser Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Lys 
        35                  40                  45              


Val Ser Ala Lys Asn Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Ser Ile Asn Asn Arg Asp Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Gly Arg Arg Arg Arg Thr Ala Asn Phe Arg Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Gly Ser Ala Ala Ala Gly Ala Pro Val Pro Tyr Pro 
145                 150                 155                 160 


Asp Pro Leu Glu Pro Arg Gly Gly Ser His His His His His His 
                165                 170                 175 


<210>  2
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH domain of CXCL12-Trap-hSDA-1

<400>  2

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Lys Val Ser Ala Lys 
            20                  25                  30          


Asn Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Asn Arg Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Arg Arg Arg Arg Thr Ala Asn Phe Arg Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  3
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-H1 of CXCL12-Trap-hSDA-1

<400>  3

Gly Val Lys Val Ser Ala Lys Asn Met Ala 
1               5                   10  


<210>  4
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-H2 of CXCL12-Trap-hSDA-1

<400>  4

Ser Ile Asn Asn Arg Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-H3 of CXCL12-Trap-hSDA-1

<400>  5

Arg Arg Arg Arg Thr Ala Asn Phe Arg Tyr 
1               5                   10  


<210>  6
<211>  176
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CXCL12-Trap-hSDA-2

<400>  6

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Gly Ser Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys 
        35                  40                  45              


Ile Asn Asn Lys Val Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Thr Ile Gln Lys Arg Gly Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Glu Ser Ala Arg Thr Ala Asp Lys Leu Gly 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Gly Ser Ala Ala Ala Gly Ala Pro Val Pro Tyr 
145                 150                 155                 160 


Pro Asp Pro Leu Glu Pro Arg Gly Gly Ser His His His His His His 
                165                 170                 175     


<210>  7
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH domain of CXCL12-Trap-hSDA-2

<400>  7

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Asn Asn Lys 
            20                  25                  30          


Val Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Gln Lys Arg Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Ala Arg Thr Ala Asp Lys Leu Gly Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  8
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR1-H1 of CXCL12-Trap-hSDA-2

<400>  8

Gly Phe Lys Ile Asn Asn Lys Val Met Ala 
1               5                   10  


<210>  9
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR1-H2 of CXCL12-Trap-hSDA-2

<400>  9

Thr Ile Gln Lys Arg Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  10
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3-H3 of CXCL12-Trap-hSDA-2

<400>  10

Glu Ser Ala Arg Thr Ala Asp Lys Leu Gly Tyr 
1               5                   10      


<210>  11
<211>  177
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CXCL12-Trap-hSDA-3

<400>  11

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Gly Ser Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Ser 
        35                  40                  45              


Phe Thr Thr Lys Asn Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Ala Ile Ser Lys Arg Ser Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Gly Leu Thr Gln Arg His Gly His Ala Lys Leu 
        115                 120                 125             


Lys Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Gly Ser Ala Ala Ala Gly Ala Pro Val Pro 
145                 150                 155                 160 


Tyr Pro Asp Pro Leu Glu Pro Arg Gly Gly Ser His His His His His 
                165                 170                 175     


His 
    


<210>  12
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH domain of CXCL12-Trap-hSDA-3

<400>  12

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Ser Phe Thr Thr Lys 
            20                  25                  30          


Asn Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Lys Arg Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Leu Thr Gln Arg His Gly His Ala Lys Leu Lys Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  13
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-H1 of CXCL12-Trap-hSDA-3

<400>  13

Gly Asp Ser Phe Thr Thr Lys Asn Met Ala 
1               5                   10  


<210>  14
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-H2 of CXCL12-Trap-hSDA-3

<400>  14

Ala Ile Ser Lys Arg Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-H3 of CXCL12-Trap-hSDA-3

<400>  15

Leu Thr Gln Arg His Gly His Ala Lys Leu Lys Tyr 
1               5                   10          


<210>  16
<211>  288
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CXCL12-Trap-VH/VL-4

<400>  16

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser 
        35                  40                  45              


Leu Thr Val Tyr Ser Val His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Gly Ala Leu Trp Gly Ser Gly Gly Thr Glu Tyr Asn 
65                  70                  75                  80  


Ser Asn Leu Lys Ser Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Gln Gly Leu Asn Tyr Gly Ser Leu Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Glu Ser Ile Ser Tyr Ser Leu Ser Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asn Ala Val Lys 
        195                 200                 205             


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Lys Gln Tyr Trp Asn Thr Pro Phe Thr Phe Gly Gln Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Arg Ala Ala Ala Gly Ala Pro Val Pro Tyr 
            260                 265                 270         


Pro Asp Pro Leu Glu Pro Arg Gly Gly Ser His His His His His His 
        275                 280                 285             


<210>  17
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH domain of CXCL12-Trap-VH/VL-4

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Val Tyr 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ala Leu Trp Gly Ser Gly Gly Thr Glu Tyr Asn Ser Asn Leu Lys 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gln Gly Leu Asn Tyr Gly Ser Leu Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  18
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL domain of CXCL12-Trap-VH/VL-4

<400>  18

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Ile Ser Tyr Ser 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Val Lys Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Lys Gln Tyr Trp Asn Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  19
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-H1 of CXCL12-Trap-VH/VL-4

<400>  19

Gly Phe Ser Leu Thr Val Tyr Ser Val His 
1               5                   10  


<210>  20
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-H2 of CXCL12-Trap-VH/VL-4

<400>  20

Ala Leu Trp Gly Ser Gly Gly Thr Glu Tyr Asn Ser Asn Leu Lys Ser 
1               5                   10                  15      


<210>  21
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-H3 of CXCL12-Trap-VH/VL-4

<400>  21

Asp Gln Gly Leu Asn Tyr Gly Ser Leu Phe Asp Tyr 
1               5                   10          


<210>  22
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-L1 of CXCL12-Trap-VH/VL-4

<400>  22

Arg Ala Ser Glu Ser Ile Ser Tyr Ser Leu Ser 
1               5                   10      


<210>  23
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-L2 of CXCL12-Trap-VH/VL-4

<400>  23

Asn Ala Val Lys Leu Glu Ser 
1               5           


<210>  24
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-L3 of CXCL12-Trap-VH/VL-4

<400>  24

Lys Gln Tyr Trp Asn Thr Pro Phe Thr 
1               5                   


<210>  25
<211>  690
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 Trap

<400>  25
atgaaatggg tcacctttat cagcctgctg ttcctgttca gcagcgccta cagcggatcc       60

ggtccgccta cctttagtcc ggcactgctg gttgttaccg aaggtgataa tgcaaccttt      120

acatgcagct ttagcaatac cagcgaaagc tttgttctga attggtatcg tatgagcccg      180

agcaatcaga ccgataaact ggcagcattt ccggaagatc gtagccagcc tggtcaggat      240

agccgttttc gtgttaccca gctgccgaat ggtcgtgatt ttcatatgag cgttgttcgt      300

gcacgtcgta atgatagcgg cacctatctg tgtggtgcaa ttagcctggc accgaaagca      360

cagattaaag aaagcctgcg tgcagaactg cgtgtgaccg aacgtcgtgc agaaggcccg      420

caaccgcaac cgaaaccgca gccgaaaccg gaaccggaac cgcaaccgca aggcggttct      480

gaggaagacc cctgtgcctg tgagtccata ctgaaatttg aggccaaggt ggagggtctg      540

ctgcaggccc tgaccaggaa gctggaagct gtgagcgggc ggctggctgt cctggagaac      600

agaatcatcg cggccgctgg cgcccctgtg ccttatcctg atcccctgga acctagaggc      660

ggcagccacc accaccatca ccactgatga                                       690


<210>  26
<211>  228
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 Trap

<400>  26

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Gly Ser Gly Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val 
            20                  25                  30          


Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser 
        35                  40                  45              


Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr 
    50                  55                  60                  


Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp 
65                  70                  75                  80  


Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met 
                85                  90                  95      


Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly 
            100                 105                 110         


Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala 
        115                 120                 125             


Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Gly Pro Gln Pro Gln Pro 
    130                 135                 140                 


Lys Pro Gln Pro Lys Pro Glu Pro Glu Pro Gln Pro Gln Gly Gly Ser 
145                 150                 155                 160 


Glu Glu Asp Pro Cys Ala Cys Glu Ser Ile Leu Lys Phe Glu Ala Lys 
                165                 170                 175     


Val Glu Gly Leu Leu Gln Ala Leu Thr Arg Lys Leu Glu Ala Val Ser 
            180                 185                 190         


Gly Arg Leu Ala Val Leu Glu Asn Arg Ile Ile Ala Ala Ala Gly Ala 
        195                 200                 205             


Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro Arg Gly Gly Ser His His 
    210                 215                 220                 


His His His His 
225             


<210>  27
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  27

Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn 
1               5                   10                  15      


Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu 
            20                  25                  30          


Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala 
        35                  40                  45              


Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val 
    50                  55                  60                  


Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala 
65                  70                  75                  80  


Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala 
                85                  90                  95      


Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr 
            100                 105                 110         


Glu Arg Arg Ala Glu 
        115         


<210>  28
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  28

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu 
    130 


<210>  29
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  29

Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala 
1               5                   10                  15      


Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe 
            20                  25                  30          


Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro 
        35                  40                  45              


Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln 
    50                  55                  60                  


Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg 
65                  70                  75                  80  


Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr 
                85                  90                  95      


Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu 
            100                 105                 110         


Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro 
        115                 120                 125             


Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln 
    130                 135                 140             


<210>  30
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  30

Ser Leu Thr Phe Tyr Pro Ala Trp Leu Thr Val Ser Glu Gly Ala Asn 
1               5                   10                  15      


Ala Thr Phe Thr Cys Ser Leu Ser Asn Trp Ser Glu Asp Leu Met Leu 
            20                  25                  30          


Asn Trp Asn Arg Leu Ser Pro Ser Asn Gln Thr Glu Lys Gln Ala Ala 
        35                  40                  45              


Phe Cys Asn Gly Leu Ser Gln Pro Val Gln Asp Ala Arg Phe Gln Ile 
    50                  55                  60                  


Ile Gln Leu Pro Asn Arg His Asp Phe His Met Asn Ile Leu Asp Thr 
65                  70                  75                  80  


Arg Arg Asn Asp Ser Gly Ile Tyr Leu Cys Gly Ala Ile Ser Leu His 
                85                  90                  95      


Pro Lys Ala Lys Ile Glu Glu Ser Pro Gly Ala Glu Leu Val Val Thr 
            100                 105                 110         


Glu Arg Ile Leu Glu 
        115         


<210>  31
<211>  147
<212>  PRT
<213>  Mus musculus

<400>  31

Ser Gly Trp Leu Leu Glu Val Pro Asn Gly Pro Trp Arg Ser Leu Thr 
1               5                   10                  15      


Phe Tyr Pro Ala Trp Leu Thr Val Ser Glu Gly Ala Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Leu Ser Asn Trp Ser Glu Asp Leu Met Leu Asn Trp Asn 
        35                  40                  45              


Arg Leu Ser Pro Ser Asn Gln Thr Glu Lys Gln Ala Ala Phe Cys Asn 
    50                  55                  60                  


Gly Leu Ser Gln Pro Val Gln Asp Ala Arg Phe Gln Ile Ile Gln Leu 
65                  70                  75                  80  


Pro Asn Arg His Asp Phe His Met Asn Ile Leu Asp Thr Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Ile Tyr Leu Cys Gly Ala Ile Ser Leu His Pro Lys Ala 
            100                 105                 110         


Lys Ile Glu Glu Ser Pro Gly Ala Glu Leu Val Val Thr Glu Arg Ile 
        115                 120                 125             


Leu Glu Thr Ser Thr Arg Tyr Pro Ser Pro Ser Pro Lys Pro Glu Gly 
    130                 135                 140                 


Arg Phe Gln 
145         


<210>  32
<211>  143
<212>  PRT
<213>  Mus musculus

<400>  32

Leu Glu Val Pro Asn Gly Pro Trp Arg Ser Leu Thr Phe Tyr Pro Ala 
1               5                   10                  15      


Trp Leu Thr Val Ser Glu Gly Ala Asn Ala Thr Phe Thr Cys Ser Leu 
            20                  25                  30          


Ser Asn Trp Ser Glu Asp Leu Met Leu Asn Trp Asn Arg Leu Ser Pro 
        35                  40                  45              


Ser Asn Gln Thr Glu Lys Gln Ala Ala Phe Cys Asn Gly Leu Ser Gln 
    50                  55                  60                  


Pro Val Gln Asp Ala Arg Phe Gln Ile Ile Gln Leu Pro Asn Arg His 
65                  70                  75                  80  


Asp Phe His Met Asn Ile Leu Asp Thr Arg Arg Asn Asp Ser Gly Ile 
                85                  90                  95      


Tyr Leu Cys Gly Ala Ile Ser Leu His Pro Lys Ala Lys Ile Glu Glu 
            100                 105                 110         


Ser Pro Gly Ala Glu Leu Val Val Thr Glu Arg Ile Leu Glu Thr Ser 
        115                 120                 125             


Thr Arg Tyr Pro Ser Pro Ser Pro Lys Pro Glu Gly Arg Phe Gln 
    130                 135                 140             


<210>  33
<211>  117
<212>  PRT
<213>  Rattus norvegicus

<400>  33

Pro Leu Thr Phe Ser Pro Thr Trp Leu Thr Val Ser Glu Gly Ala Asn 
1               5                   10                  15      


Ala Thr Phe Thr Cys Ser Phe Ser Asn Trp Ser Glu Asp Leu Lys Leu 
            20                  25                  30          


Asn Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Glu Lys Gln Ala Ala 
        35                  40                  45              


Phe Cys Asn Gly Tyr Ser Gln Pro Val Arg Asp Ala Arg Phe Gln Ile 
    50                  55                  60                  


Val Gln Leu Pro Asn Gly His Asp Phe His Met Asn Ile Leu Asp Ala 
65                  70                  75                  80  


Arg Arg Asn Asp Ser Gly Ile Tyr Leu Cys Gly Ala Ile Ser Leu Pro 
                85                  90                  95      


Pro Lys Ala Gln Ile Lys Glu Ser Pro Gly Ala Glu Leu Val Val Thr 
            100                 105                 110         


Glu Arg Ile Leu Glu 
        115         


<210>  34
<211>  143
<212>  PRT
<213>  Rattus norvegicus

<400>  34

Leu Glu Val Leu Asn Lys Pro Trp Arg Pro Leu Thr Phe Ser Pro Thr 
1               5                   10                  15      


Trp Leu Thr Val Ser Glu Gly Ala Asn Ala Thr Phe Thr Cys Ser Phe 
            20                  25                  30          


Ser Asn Trp Ser Glu Asp Leu Lys Leu Asn Trp Tyr Arg Leu Ser Pro 
        35                  40                  45              


Ser Asn Gln Thr Glu Lys Gln Ala Ala Phe Cys Asn Gly Tyr Ser Gln 
    50                  55                  60                  


Pro Val Arg Asp Ala Arg Phe Gln Ile Val Gln Leu Pro Asn Gly His 
65                  70                  75                  80  


Asp Phe His Met Asn Ile Leu Asp Ala Arg Arg Asn Asp Ser Gly Ile 
                85                  90                  95      


Tyr Leu Cys Gly Ala Ile Ser Leu Pro Pro Lys Ala Gln Ile Lys Glu 
            100                 105                 110         


Ser Pro Gly Ala Glu Leu Val Val Thr Glu Arg Ile Leu Glu Thr Pro 
        115                 120                 125             


Thr Arg Tyr Pro Arg Pro Ser Pro Lys Pro Glu Gly Gln Phe Gln 
    130                 135                 140             


<210>  35
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  35

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  36
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  36

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro 
        195                 200 


<210>  37
<211>  219
<212>  PRT
<213>  Mus musculus

<400>  37

Phe Thr Ile Thr Ala Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Val Thr Met Glu Cys Arg Phe Pro Val Glu Arg Glu Leu Asp Leu 
            20                  25                  30          


Leu Ala Leu Val Val Tyr Trp Glu Lys Glu Asp Glu Gln Val Ile Gln 
        35                  40                  45              


Phe Val Ala Gly Glu Glu Asp Leu Lys Pro Gln His Ser Asn Phe Arg 
    50                  55                  60                  


Gly Arg Ala Ser Leu Pro Lys Asp Gln Leu Leu Lys Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Cys Cys 
                85                  90                  95      


Ile Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Leu Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Arg Lys Ile Asn Gln Arg Ile Ser Val Asp Pro Ala 
        115                 120                 125             


Thr Ser Glu His Glu Leu Ile Cys Gln Ala Glu Gly Tyr Pro Glu Ala 
    130                 135                 140                 


Glu Val Ile Trp Thr Asn Ser Asp His Gln Pro Val Ser Gly Lys Arg 
145                 150                 155                 160 


Ser Val Thr Thr Ser Arg Thr Glu Gly Met Leu Leu Asn Val Thr Ser 
                165                 170                 175     


Ser Leu Arg Val Asn Ala Thr Ala Asn Asp Val Phe Tyr Cys Thr Phe 
            180                 185                 190         


Trp Arg Ser Gln Pro Gly Gln Asn His Thr Ala Glu Leu Ile Ile Pro 
        195                 200                 205             


Glu Leu Pro Ala Thr His Pro Pro Gln Asn Arg 
    210                 215                 


<210>  38
<211>  200
<212>  PRT
<213>  Mus musculus

<400>  38

Leu Phe Thr Val Thr Ala Pro Lys Glu Val Tyr Thr Val Asp Val Gly 
1               5                   10                  15      


Ser Ser Val Ser Leu Glu Cys Asp Phe Asp Arg Arg Glu Cys Thr Glu 
            20                  25                  30          


Leu Glu Gly Ile Arg Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Leu Gln Ser Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Ser Val Gln Val Arg Asp Ser Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Leu Val Ile Cys Gly Ala Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Val Lys Val Lys Ala Ser Tyr Met Arg Ile Asp Thr Arg Ile Leu 
            100                 105                 110         


Glu Val Pro Gly Thr Gly Glu Val Gln Leu Thr Cys Gln Ala Arg Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Gln Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ile Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Gln Pro Ser Arg Asn Phe Ser Cys Met Phe Trp 
                165                 170                 175     


Asn Ala His Met Lys Glu Leu Thr Ser Ala Ile Ile Asp Pro Leu Ser 
            180                 185                 190         


Arg Met Glu Pro Lys Val Pro Arg 
        195                 200 


<210>  39
<211>  219
<212>  PRT
<213>  Rattus norvegicus

<400>  39

Phe Thr Ile Thr Ala Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Val Thr Met Glu Cys Arg Phe Pro Val Glu Gln Lys Leu Asp Leu 
            20                  25                  30          


Leu Ala Leu Val Val Tyr Trp Glu Lys Glu Asp Lys Glu Val Ile Gln 
        35                  40                  45              


Phe Val Glu Gly Glu Glu Asp Leu Lys Pro Gln His Ser Ser Phe Arg 
    50                  55                  60                  


Gly Arg Ala Phe Leu Pro Lys Asp Gln Leu Leu Lys Gly Asn Ala Val 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Cys Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Leu Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Arg Lys Ile Asn Gln Arg Ile Ser Met Asp Pro Ala 
        115                 120                 125             


Thr Ser Glu His Glu Leu Met Cys Gln Ala Glu Gly Tyr Pro Glu Ala 
    130                 135                 140                 


Glu Val Ile Trp Thr Asn Ser Asp His Gln Ser Leu Ser Gly Glu Thr 
145                 150                 155                 160 


Thr Val Thr Thr Ser Gln Thr Glu Glu Lys Leu Leu Asn Val Thr Ser 
                165                 170                 175     


Val Leu Arg Val Asn Ala Thr Ala Asn Asp Val Phe His Cys Thr Phe 
            180                 185                 190         


Trp Arg Val His Ser Gly Glu Asn His Thr Ala Glu Leu Ile Ile Pro 
        195                 200                 205             


Glu Leu Pro Val Pro Arg Leu Pro His Asn Arg 
    210                 215                 


<210>  40
<211>  200
<212>  PRT
<213>  Rattus norvegicus

<400>  40

Leu Phe Thr Val Thr Ala Pro Lys Glu Val Tyr Thr Val Asp Phe Gly 
1               5                   10                  15      


Ser Ser Val Ser Leu Glu Cys Asp Phe Asp Arg Arg Glu Cys Thr Glu 
            20                  25                  30          


Leu Glu Gly Ile Arg Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Ser Gln Ser Gln Arg Ala Thr Leu Leu Glu Glu Leu Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Ser Val Gln Val Arg Asp Ser Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Leu Val Ile Cys Gly Ala Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Val Lys Val Lys Ala Ser Tyr Val Arg Ile Asp Thr Gly Ile Leu 
            100                 105                 110         


Glu Val Pro Gly Thr Gly Glu Val Gln Leu Ile Cys Gln Ala Arg Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Gln Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ile Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Gln Pro Asn Arg Asn Phe Ser Cys Met Phe Trp 
                165                 170                 175     


Asn Ala His Met Lys Glu Leu Thr Ser Ala Ile Ile Asp Pro Leu Ser 
            180                 185                 190         


Trp Met Glu Pro Lys Val Pro Arg 
        195                 200 


<210>  41
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  41

Glu Glu Asp Pro Cys Ala Cys Glu Ser Leu Val Lys Phe Gln Ala Lys 
1               5                   10                  15      


Val Glu Gly Leu Leu Gln Ala Leu Thr Arg Lys Leu Glu Ala Val Ser 
            20                  25                  30          


Lys Arg Leu Ala Ile Leu Glu Asn Thr Val Val 
        35                  40              


<210>  42
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  42

Glu Glu Asp Pro Cys Ala Cys Glu Ser Leu Val Thr Phe Gln Ala Lys 
1               5                   10                  15      


Val Glu Gly Leu Leu Gln Ala Leu Thr Arg Lys Leu Glu Ala Val Ser 
            20                  25                  30          


Lys Arg Leu Ala Ile Leu Glu Asn Thr Val Val 
        35                  40              


<210>  43
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  43

Glu Glu Asp Pro Cys Ala Cys Glu Ser Leu Val Lys Phe Gln Ala Lys 
1               5                   10                  15      


Val Glu Gly Leu Leu Gln Ala Leu Thr Ser Pro Leu Glu Ala Val Ser 
            20                  25                  30          


Lys Arg Leu Ala Ile Leu Glu Asn Thr Val Val 
        35                  40              


<210>  44
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  44

Leu Arg Ser Pro Cys Glu Cys Glu Ser Leu Val Glu Phe Gln Gly Arg 
1               5                   10                  15      


Thr Leu Gly Ala Leu Glu Ser Leu Thr Leu Asn Leu Ala Gln Leu Thr 
            20                  25                  30          


Ala Arg Leu Glu Asp Leu Glu Asn Gln Leu Ala Asn Gln Lys 
        35                  40                  45      


<210>  45
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  45

His Asp Gln Cys Lys Cys Glu Asn Leu Ile Met Phe Gln Asn Leu Ala 
1               5                   10                  15      


Asn Glu Glu Val Arg Lys Leu Thr Gln Arg Leu Glu Glu Met Thr Gln 
            20                  25                  30          


Arg Met Glu Ala Leu Glu Asn Arg Leu Arg Tyr Arg 
        35                  40                  


<210>  46
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  46

Thr Glu Asp Ala Cys Gly Cys Glu Ala Thr Leu Ala Phe Gln Asp Lys 
1               5                   10                  15      


Val Ser Ser Tyr Leu Gln Arg Leu Asn Thr Lys Leu Asp Asp Ile Leu 
            20                  25                  30          


Glu Lys Leu Lys Ile Asn Glu Tyr Gly Gln Ile His Arg 
        35                  40                  45  


<210>  47
<211>  43
<212>  PRT
<213>  Mus musculus

<400>  47

Glu Glu Asp Pro Cys Ala Cys Glu Ser Ile Leu Lys Phe Glu Ala Lys 
1               5                   10                  15      


Val Glu Gly Leu Leu Gln Ala Leu Thr Arg Lys Leu Glu Ala Val Ser 
            20                  25                  30          


Gly Arg Leu Ala Val Leu Glu Asn Arg Ile Ile 
        35                  40              


<210>  48
<211>  46
<212>  PRT
<213>  Mus musculus

<400>  48

Leu Arg Ser Pro Cys Glu Cys Glu Ser Leu Val Glu Phe Gln Gly Arg 
1               5                   10                  15      


Thr Leu Gly Ala Leu Glu Ser Leu Thr Gln Asn Leu Ala Arg Leu Thr 
            20                  25                  30          


Glu Arg Leu Glu Glu Leu Glu Asn Gln Leu Ala Ser Arg Lys 
        35                  40                  45      


<210>  49
<211>  45
<212>  PRT
<213>  Mus musculus

<400>  49

Thr Gln Asp Gln Cys Lys Cys Glu Asn Leu Ile Gln Phe Gln Asn Leu 
1               5                   10                  15      


Ala Asn Glu Glu Val Arg Lys Leu Thr Gln Arg Leu Glu Glu Met Thr 
            20                  25                  30          


Gln Arg Met Glu Ala Leu Glu Asn Arg Leu Arg Tyr Arg 
        35                  40                  45  


<210>  50
<211>  43
<212>  PRT
<213>  Mus musculus

<400>  50

Asp Gln Cys Lys Cys Glu Asn Leu Ile Leu Phe Gln Asn Val Ala Asn 
1               5                   10                  15      


Glu Glu Val Arg Lys Leu Thr Gln Arg Leu Glu Glu Met Thr Gln Arg 
            20                  25                  30          


Met Glu Ala Leu Glu Asn Arg Leu Lys Tyr Arg 
        35                  40              


<210>  51
<211>  44
<212>  PRT
<213>  Mus musculus

<400>  51

Glu Asp Ala Cys Gly Cys Gly Ala Thr Leu Ala Phe Gln Glu Lys Val 
1               5                   10                  15      


Ser Ser His Leu Gln Lys Leu Asn Thr Lys Leu Asp Asn Ile Leu Lys 
            20                  25                  30          


Lys Leu Lys Val Thr Glu Tyr Gly Gln Val His Arg 
        35                  40                  


<210>  52
<211>  43
<212>  PRT
<213>  Ceratotherium simum

<400>  52

Glu Glu Asp Pro Cys Ala Cys Glu Ser Ile Val Lys Phe Gln Ala Lys 
1               5                   10                  15      


Val Glu Gly Leu Leu Gln Ala Leu Thr Arg Lys Leu Glu Ala Val Ser 
            20                  25                  30          


Lys Arg Leu Ala Val Leu Glu Asn Arg Ile Val 
        35                  40              


<210>  53
<211>  43
<212>  PRT
<213>  Nannospalax galili

<400>  53

Glu Glu Asp Pro Cys Ala Cys Glu Ser Ile Val Arg Phe Glu Ala Lys 
1               5                   10                  15      


Val Glu Gly Leu Leu Gln Ala Leu Thr Arg Lys Leu Glu Ala Val Ser 
            20                  25                  30          


Lys Arg Leu Ala Val Leu Glu Asn Arg Ile Val 
        35                  40              


<210>  54
<211>  43
<212>  PRT
<213>  Bison bison

<400>  54

Glu Glu Asp Pro Cys Ala Cys Glu Ser Ile Val Lys Phe Gln Thr Lys 
1               5                   10                  15      


Val Glu Gly Leu Leu Gln Ala Leu Thr Arg Lys Leu Glu Ala Val Ser 
            20                  25                  30          


Lys Arg Leu Ala Val Leu Glu Asn Arg Ile Val 
        35                  40              


<210>  55
<211>  43
<212>  PRT
<213>  Rattus norvegicus

<400>  55

Glu Glu Asp Pro Cys Ala Cys Glu Ser Ile Val Arg Phe Glu Ala Lys 
1               5                   10                  15      


Val Glu Gly Leu Leu Gln Asp Leu Thr Arg Lys Leu Glu Ala Val Ser 
            20                  25                  30          


Lys Arg Leu Ala Val Leu Glu Asn Arg Val Ile 
        35                  40              


<210>  56
<211>  46
<212>  PRT
<213>  Rattus norvegicus

<400>  56

Glu Thr Gln Asp Gln Cys Lys Cys Glu Asn Leu Ile Gln Phe Gln Asn 
1               5                   10                  15      


Leu Ala Asn Glu Glu Val Arg Lys Leu Thr Gln Arg Leu Glu Glu Met 
            20                  25                  30          


Thr Gln Arg Met Glu Ala Leu Glu Asn Arg Leu Arg Tyr Arg 
        35                  40                  45      


<210>  57
<211>  26
<212>  PRT
<213>  Rattus norvegicus

<400>  57

Glu Asp Ala Cys Ser Cys Gly Ala Thr Leu Ala Phe Gln Glu Lys Val 
1               5                   10                  15      


Ser Ser His Leu Gln Lys Leu Asn Thr Thr 
            20                  25      


<210>  58
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker sequence


<220>
<221>  REPEAT
<222>  (1)..(11)
<223>  linker sequence can be repeated n times, wherein n=1-20

<400>  58

Gly Pro Gln Pro Gln Pro Lys Pro Gln Pro Lys 
1               5                   10      


<210>  59
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker sequence


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  linker sequence can be repeated n times, wherein n=1-20

<400>  59

Gly Gly Gly Gly Ser 
1               5   


<210>  60
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  60

Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro 
1               5                   10                  15  


<210>  61
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  61

Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro 
1               5                   10                  15      


<210>  62
<211>  16
<212>  PRT
<213>  Camelus dromedarius

<400>  62

Pro Gln Pro Gln Pro Gln Pro Lys Pro Gln Pro Lys Pro Glu Pro Glu 
1               5                   10                  15      


<210>  63
<211>  1543
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CXCL12 trap

<400>  63
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atggtgatgc ggttttggca gtacatcaat gggcgtggat      420

agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt      480

tttggcacca aaatcaacgg gactttccaa aatgtcgtaa caactccgcc ccattgacgc      540

aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctctc tggctaacta      600

gagaacccac tgcttactgg cttatcgaaa ttaatacgac tcactatagg gagacccaag      660

ctggctagcc accatgaaat gggtcacctt tatcagcctg ctgttcctgt tcagcagcgc      720

ctacagcgga tccgaggtgc agctggtgga atctggcgga ggactggtgc agcctggcgg      780

ctctctgaga ctgtcttgtg ccgccagcgg cttcagcctg accgtgtact ctgtgcactg      840

ggtgcgccag gccccaggca aaggactgga atgggtggga gccctgtggg gctctggcgg      900

aaccgagtac aacagcaacc tgaagtcccg gttcaccatc agccgggaca ccagcaagaa      960

caccgtgtac ctgcagatga acagcctgcg ggccgaggac accgccgtgt actattgcgc     1020

cagagatcag ggcctgaact acggcagcct gttcgactat tggggccagg gcacactcgt     1080

gaccgtgtct agcggaggcg gaggaagtgg cggaggggga tctggcggcg gaggcagcga     1140

tattcagatg acccagtccc ccagcagcct gagcgcctct gtgggcgaca gagtgaccat     1200

cacctgtcgg gccagcgaga gcatcagcta cagcctgtcc tggtatcagc agaagcccgg     1260

caaggccccc aagctgctga tctacaacgc cgtgaagctg gaaagcggcg tgcccagcag     1320

attttccggc agcggctctg gcaccgactt caccctgacc atcagctccc tgcagcccga     1380

ggacttcgcc acctactact gcaagcagta ctggaacacc cccttcacct tcggacaggg     1440

caccaaggtg gaaatcaaga gagcggccgc tggcgcccct gtgccttatc ctgatcccct     1500

ggaacctaga ggcggcagcc accaccacca tcaccactga tga                       1543


<210>  64
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Lys 
                85                  


<210>  65
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Lys Arg Phe Lys Met 
                85                  90              


<210>  66
<211>  18818
<212>  DNA
<213>  Homo sapiens

<400>  66
ctttcaggct tctgggacag atcctaggtc cagctgccca cctgattttg tggcaaagaa       60

aaaaagaaga agaagaagcg agaggcgatg gcgtttgctt tggccagatt taagggcaag      120

cgaggctgcg cgcggctccc gcagggtcgg atctccgagc tccagggcgc ccctccaccc      180

gggtgtagat ttcccgcgga ccccttcgcc ctcccgggtt tcatcagctg cgcaggaatg      240

gagctggcca gagctctggg agcggggagg gaggcgccgc caccagaggg cgccggagcc      300

ccagcgctgc ggccggtgag cggccaggct ccccggccca gcccagcaaa ggcctgggga      360

cgcccgacgg ctgccttctt cactggacct cactgccttc agttctttaa gagcagggcc      420

aagtcagtgg ggttcccggc tccaagccca gtgcccaggg tgggtgggtg ggtgggtggg      480

tgggtggatg gatggatgga tggatggatg gagtgccggc ccacagccat ctaacggcca      540

aagtggtttt ggaaaaaaaa tgcacagaag acacctactc ccaccagcgg agttccggag      600

ccctcgcagc ctcctgttga ccgctcccgc ctaatgcagc cgctgaccgc ccactccccg      660

acggccagga ctccccaggg acagggacgt gtccccaggg caggcccctg gatggacgcg      720

gcgactgacc ccacttcgct ggacgctgtg ctgggaagga cacagagagg tggctggggc      780

agcctgcggt cacaaagcga ggcccaaagg ggcgctctcc tcacccccac gcctcctggg      840

tgccgacctg caccctccct tcgccaccgg actggggcca tctgggatgt ctcgggggta      900

tccggagggc taagcaccgc cgagggacgg ctccgtggga agagttttct ggacccagaa      960

ggcagacgcc agtagtactg tcctaggagt cggaggtcgg ggtgggggag ttctcagctc     1020

tttgggtcgc acggagcttt tcttgggtaa ggcagtaagt acttaggttt aaaggactta     1080

cttacagcta ccatttattg agtactgtct gcttgtcaga cacgatgcag agaatttcgc     1140

ggcgtggggc gggtctcatt gaatctcccg tcccactccg cggggtgggc ctgtgattag     1200

ctcatttcac cattgagagg tcggaagtac aaaggctaca ttcgctttta ctgagagccg     1260

ccggcgcctt ctgctttgtt tgtacaggcg aggaaactga ggctcggctg gtggcgccgt     1320

gggcttggag tccgagccac gctgactgca aagacgggtc tcattcccgc agatcgagct     1380

ctgccggcgg ctgcgccgca agccgggcag gtggcgagct tgagccccca cgcacagaaa     1440

gcaggacccc ctcggctgcc ttgggccgcc accgccagca ggccctccgc ccgggactaa     1500

cttgtttgct tttcattggt tctcattcag ttcccgccat cgaaaggccc cgtcccgcag     1560

ctttccacgc gcgccccact ttacgcctaa ggtcctcagt ctctccagtg gggccctgtc     1620

acagggacaa taagcggccc tccagccggc gtcgctcagg ctgcggacct cactgcagac     1680

cgggccagcg gtgcggggcc cagcggagcc tgagaaggtc aaaggccgga gcgcactgcg     1740

cctcgggagc acagagggag cggaggaggg gcgaagggga tgggtggggg gtgccgccga     1800

gggagtcgcg cgtcagagac cccggccacg gccagcactc ggctccgggc ccgcccctca     1860

ccgcgcgccc cgccccgccc cgcctggctc tcccctctaa agcgcccggc gcgcgcctcc     1920

caccgccgca ctttcactct ccgtcagccg cattgcccgc tcggcgtccg gcccccgacc     1980

cgcgctcgtc cgcccgcccg cccgcccgcc cgcgccatga acgccaaggt cgtggtcgtg     2040

ctggtcctcg tgctgaccgc gctctgcctc agcgacggta agtgcgctcg gcggggaggc     2100

cctggcgagg cggccctggc gaggctctgg gcttcggctc ccgcccggcg cagagccgcg     2160

gctcctctgc ctgcgcccgc agtttgcgcc gcccgacaca gtgggggtgg aggcagctcg     2220

cttagctggg cgctctggtg cggtgtcgcg ttcaaagccc tacttttgcg ccgagggttt     2280

gtgacctgca gagagcgacc gcctgacctc aagctggctg cagagcgagg tcagccggga     2340

caactgggca ggaacgcccc aagagagcgt tcgggactgg cgcgggaagg cgcgagggtg     2400

gggagccgcg gaccccagac ccctgcctgc ccaccctcca cccactgcct tcccgctgcg     2460

ggctcggttt ccacaggcga atgggctccg aggtcctgct gcgcacagtg ctggaggtcg     2520

ggcggtgcat ggcgagagcg cgctttgcaa agttcgcctc atgccgcgac ttgaggctgt     2580

gaggtccgat gcagccgcgc agcctccgct ccctgcgaag ccgatcctct ccccacaccc     2640

tcgcggggct cttggccagg cgcgggcggg ctgcgcggcg cagctgtcgg gcttgtgcca     2700

cccgccaggc cgcgcttctg cacagctccg cggtccgcag cgacgcggac ctgggcgcgc     2760

gtccagccgc tgtcttcctg tctcttctcg ggttcacctg agagaggccc agggaccctc     2820

cgagcctcac acgccccctc cccagctccc caaacacacc tgcagacagg ctcttttgtc     2880

accagctggc caagcgcttt gccccagaat gagagctgca gcaaagttca atctccaagg     2940

ccctgggcca ctgggaaccg tggtgtcccg tttcactggg agagggcttt tttcttttct     3000

ttcgctgaag agaaactcgc tgcgctgtca caggacaccg atgcaaacca aaataaactg     3060

ttgcctctga acacacaaaa caaaaccctg tggctcaggc cgctgagctt ccttggctgt     3120

gaagtttcct gcaaagagtt gaaggacact ctgagtgctc ttgcagccgc gggctgtgca     3180

ggcccagcgc gcctcgagcc cttggctggg ttggtgcaga cgtggccccg gcgtcctagc     3240

tggcttggac tgtgcgctgg tgtgagcagg accagcgcag ctgagtcggg ctggagaagc     3300

tgggcagcct ggggtcgtgg cggactgcct aagtgttaag gacacagact gaaggcaatt     3360

gggaatgttc gtcgttgatg aaaagtccct gaggctgtgt ctgcacactg accccccccc     3420

ccccccgcaa gtcatggggc atgtttctag tttttattgc tggatattct tctgttcctg     3480

taaggtctct ggtttgggca gttattgact gattggtggg atgagcgcgg aggtgtcaca     3540

gtgcgccgct ctgggaaatg gtgctgcccc ctccccggag ggctggagag aggattggaa     3600

tgaggaacct cggtctttga gttatgggtg caactgacct gggggaagca cagagacgtg     3660

gggttcatcc cagactcctc ctggcctggg aagggtgaca tggccctcag agttgcccca     3720

ttggcagcca agtaaccagg gcaggagcct gggctccagg cagatctgct ccttacacac     3780

atcgccagaa tgttttgttt tgttttgttt tcccctcacc tcacagtgcc tatgtgcccc     3840

ctatccccac acttagtcct caagctgcac tacagagaga gcttggccag gggtcctgcc     3900

cctcccccat tggctgactt ccgtcaggca gctgggccct tgggtttccc gggcttaaac     3960

tcagggtggg cccccttccc aagcctgctt ggaggggcca gctgggctcc tgtctctgca     4020

ttagactgga gggctttctg aaaactcctg gagccaagct cacccggtcc caaatccggg     4080

gtaccatcag agccagtcag gactcttgcc ggtacacgga tttacatcca gaacggttgg     4140

gaaagttagt cttactgaca aaaagctgga ggaaggagca catgaggtac acacgagacc     4200

atgttctttt ggtaagcaca cctgggggct ctgtcacttt aaaaagacct gttgaaattc     4260

gctgcttgac aggcgggcct taggtcctgg gagtagaagc aagaattgct tttgaaggaa     4320

atggataatc ccagggggtg gagggggaga ggagagagag cctgtgtgtt gagctctgaa     4380

taggctctga tttctggcct catcaccact gcttggttgg ggggccagag gagcttctct     4440

cctctgggcg ctggagagtc acagccccac ccatcccagc gggggcggct gcagcacttg     4500

cccttggctg catatcttca agctcactgt tgccgggagg gggcttgtgc ctcactaccg     4560

gcctcctatt ctcctgctcc acccccaacc caccccctgc ctcagcttgg aagggcccaa     4620

aagaaatcca gggaaacctg gaggcacaac actcaggagc gtttagctcc tcagttaccc     4680

aggctgcagg ccccggccct gggggtggct ttcccaggtg atctggttac agtgcagtgc     4740

tgacttcccc tgcagggtcc cagtgcagct gctggaagct ggccccagag gtgcctttct     4800

ggagttagat caggtgtaac tgtgaaggct gctttaggtc tctccagtgc catgagtcac     4860

cagcaccctg atgcttggct ttttcctggt tttcagggag ttgcatttgg tcctggggac     4920

aaggaagtgg ggggacaagt ggtccacttt tcctgcaact tggtggctga atacacaatg     4980

caattcctag tccacatcat ccctcaattg attgcagtct gtagaaaaaa taaaataaaa     5040

tgagcccctt actcaagatt tcctcctact tccccagcat tctttcccaa aggtgcagaa     5100

tttcagaacc acagaggtct ctcagaactt tgtaaacagg caaacttaaa aaaaaagaaa     5160

aaagaaaaaa aatctctgga ccaaatattc ttagacatat atttaatctc tgatgaaagg     5220

atccacaagt tcaaataatt tggggtatta agtggggctt ggataaaatc ttcaaggaaa     5280

aaagaaaaac aaaaagcaca cacaaatccc agccctccag ggcttgcaat cctatattta     5340

aagggtgagc agtgggttct gcaggagccc cttgctaatt tacactaatg agtgtcaatt     5400

atggcatttt gtaaattggt gattttgcaa agatcttaat acaattcctg aggctacagc     5460

atccctgcct aggcaatgaa aaccacattt aactccagct ccactaatct ctaagccttg     5520

gggaaagtgc tgggcagaag gtgggtcctt ggcctgctct caggggactc acaggtagga     5580

agccagccag gattcttttg tgccttccag agctttaggt gaatgtgagg aggggtctct     5640

ggggtggggg agggcagcat tcctgagtac tactgtgctt cctggctaga ggcctgtgcc     5700

agaggagaga ggccagggag cctggagcct cttgtccccc tttcttttcc ctgagtaggg     5760

agatctttct cagttgtccc ttgaggaatt ttttttacaa agagtaactg gaaatttcag     5820

taccttggac tgaaaccgtt atctactata attactacct ttatcttgag acactgagca     5880

ggtggcttct aatttaatct cccccctcat ctaggctccg gctctcccca ggcctgttgg     5940

gctccttgcc ctgtagaagc tgagcctgag ctcagccagc actcactgtg ttgcctgagg     6000

agatggcctt tcccaacata caccagtaac ctggaactta ccccagtgat gccgtctctt     6060

gatccttaat cgctgcacca actgctgcag cccagacaca cattaccaaa atctggcagg     6120

gtagtaaagt gccttgttgt ccttacctct tctagggaag cccgtcagcc tgagctacag     6180

atgcccatgc cgattcttcg aaagccatgt tgccagagcc aacgtcaagc atctcaaaat     6240

tctcaacact ccaaactgtg cccttcagat tgtgtaagtc ttgaaattga acatcatcta     6300

acgaacatag ttgcatctaa cgaacatagt aacatctaac ccgagtctta ttaaaggtgt     6360

agaggtgaca agccaagtgt ccaaccttga acttggcata attagtggca gctattctta     6420

tcatgaggac ctttagtatg ccaccaggca ttaattttaa aagccgctct tggcctgggc     6480

accctgctgt gctcgtagta gttctctctt ctttccaaac ctgtgttctt cagcacagca     6540

cagctggatg ctggagaaac tatgggcttc accaaggttt tggctgaagc ctagtaaatt     6600

agccagccct tagctaataa cagtgataac tggcctgcca gtttcgggga tctgatgccc     6660

tacattaact cacaagaccc aaatgcagtt taagtcctct ttaaccattg ggtgaaactt     6720

caacattttc agctcacttg cctgtatttt ctcaagtaca acatatgagg ttttggtgtt     6780

atttggtgtg gatggcagcc actaacattt gattttattc atttgggaaa caaagaccaa     6840

aatcacacat ccacaagaca ggaagatctc agctgggtac agaagaccgg gagaaatgcg     6900

ggaagaaagc catgtgcttg aaagccctct catgctcaag aggtcctgtg tctgaacacg     6960

gggaagcgag ggctcaggga gtctcctgga gaggatttga ttgctcagaa gttctagtgc     7020

taaaaatggg gtggggagac agcagttgga accaaagcta caactttccc aagacttttc     7080

cacccaacac caaatgtttt tacttttgat tttagaaaac tgtttttagt tttgagttaa     7140

ccctttactg ccttgaatgt gtttgttatt tacagtatgt tttagggccc tagaaaatga     7200

atgttttttc agtactttgc ctacaacatg atactttatc tcttgtgaag agtattttaa     7260

agatgctcaa tttagctagc ttggacctgc tttacagcac tgatcatgct ggtttactgg     7320

cctggaaatg caccttgaag ttgaagatgc caaatacaat tctcaggtct gagcagacac     7380

taaattaaca aagaataggc cccagatttg gaccccaatg tgggttgctc cgagccacac     7440

ccatctctgc acccctcttc acctaatgga caggctgctt gaagactccc tgggtgcccc     7500

tgaaccactg ttctggggct tagctgtcct caagaccctt aagtacttgg gctgcatgag     7560

attacctggc accaaagggc tttctggcaa gagatccaga gagatgaaat caggccttcc     7620

ccaggagttt gcatgtaggg aagcttttaa gagtgtgaac ttttaaaaaa caaatgagac     7680

caagaaacat tcagtgaact tgtaaaatct ttctagaaac tattttctgg taagccacct     7740

gcactgcccc tcccctccct ggctggtcac cctcccggtc agaccgcggt gacttctggc     7800

aggcctcctt cctccaggct tcctcatgcc catccttaag tcggccctat atctatcaag     7860

atgacccatc caaataaacc tctgctctgt tgctctccat tctcccctcc ccaggtgcct     7920

agagcatcct gtcgtcccct tcctcagttt cctctgtatg ctttgatgac ccccctggcg     7980

tatttgctcc tgattttccc ttcccgttta tttactctcc aagctcctac ttatccttca     8040

aaggcagctc aaatgctccc ttacatgaat tcccctgcac tgccccggaa agacttctgt     8100

tcacatttcc atgtctctgc aatggaactt cctgcactgc cagcgctgag ctttccccag     8160

cacaccgcga gcacctctgg agcctgagcg taccaagtgg agcacggggt gccagcgagg     8220

gccctagatg ggtgttgggg gagcggatgc acacgttgca gccgcgcctt cctcctgtgc     8280

agccgcacac tgttgccatt ctgttttcac agagcccggc tgaagaacaa caacagacaa     8340

gtgtgcattg acccgaagct aaagtggatt caggagtacc tggagaaagc tttaaacaag     8400

taagcacaac agccaaaaag gactttccgc tagacccact cgaggaaaac taaaaccttg     8460

tgagagatga aagggcaaag acgtggggga gagggggcct taaccatgag gaccaggtgt     8520

gtgtgtgggg tgggcacatt gatctgggat cgggcctgag gtttgccagc atttagaccc     8580

tgcatttata gcatacggta tgatattgca gcttatattc atccatgccc tgtacctgtg     8640

cacgttggaa cttttattac tggggttttt ctaagaaaga aattgtatta tcaacagcat     8700

tttcaagcag ttagttcctt catgatcatc acaatcatca tcattctcat tctcattttt     8760

taaatcaacg agtacttcaa gatctgaatt tggcttgttt ggagcatctc ctctgctccc     8820

ctggggagtc tgggcacagt caggtggtgg cttaacaggg agctggaaaa agtgtccttt     8880

cttcagacac tgaggctccc gcagcagcgc ccctcccaag aggaaggcct ctgtggcact     8940

cagataccga ctggggctgg gcgccgccac tgccttcacc tcctctttca acctcagtga     9000

ttggctctgt gggctccatg tagaagccac tattactggg actgtgctca gagacccctc     9060

tcccagctat tcctactctc tccccgactc cgagagcatg cttaatcttg cttctgcttc     9120

tcatttctgt agcctgatca gcgccgcacc agccgggaag agggtgattg ctggggctcg     9180

tgccctgcat ccctctcctc ccagggcctg ccccacagct cgggccctct gtgagatccg     9240

tctttggcct cctccagaat ggagctggcc ctctcctggg gatgtgtaat ggtccccctg     9300

cttacccgca aaagacaagt ctttacagaa tcaaatgcaa ttttaaatct gagagctcgc     9360

tttgagtgac tgggttttgt gattgcctct gaagcctatg tatgccatgg aggcactaac     9420

aaactctgag gtttccgaaa tcagaagcga aaaaatcagt gaataaacca tcatcttgcc     9480

actaccccct cctgaagcca cagcagggtt tcaggttcca atcagaactg ttggcaaggt     9540

gacatttcca tgcataaatg cgatccacag aaggtcctgg tggtatttgt aactttttgc     9600

aaggcatttt tttatatata tttttgtgca catttttttt tacgtttctt tagaaaacaa     9660

atgtatttca aaatatattt atagtcgaac aattcatata tttgaagtgg agccatatga     9720

atgtcagtag tttatacttc tctattatct caaactactg gcaatttgta aagaaatata     9780

tatgatatat aaatgtgatt gcagcttttc aatgttagcc acagtgtatt ttttcacttg     9840

tactaaaatt gtatcaaatg tgacattata tgcactagca ataaaatgct aattgtttca     9900

tggtataaac gtcctactgt atgtgggaat ttatttacct gaaataaaat tcattagttg     9960

ttagtgatgg agcttataga cgtttctggt ttatatagtt aagcctgcct gcagtcaggt    10020

gtctgagacc ccttctcaca gcccatgtgt gacagtgtat gggcttttct cacgagcaga    10080

ttagatctgc agctcaagtt tttggatctt tttttttttt ttttaacccg attgaaatag    10140

cagtgctggt tttctgaaga ataatatttg actcactaat tcgtcttccc tccctcctcc    10200

tccttggttc tcctaacttc cccatgtaat ccccagagac tcaaccctag taatatcaac    10260

cttttacatt ttcccatgta aaaatcccat gactccaggc catggttaat atgaagcttt    10320

cacagggaca ggtggcctca ccccataaat cattaaatac cattcagctt gaatcatttt    10380

aatgtgacag tcacgagcca gttgctctaa taaaattctg ctaaccagct ctctcccttg    10440

ctctccagaa caatcgcatt cattcccagg agtgttcaca ggcgtctaga aaggggaagg    10500

tgggaccact gccttttttc tcctcttctg aatggcagtc tgaacctggg gcctgcagcc    10560

tccaaaacgt tattcaattt gaaatgcaga catttcttag agaaagctaa gagttcagcc    10620

ctgcattgag aagaagaaaa agtcccatga gagcagggca gggtggggtg acaaggacca    10680

cgatggccag cctggccctg ggtgtaccct gagatgtgga ttccttgtcc ccagtgggaa    10740

tcaggttcag gttggcagat tggcagtcgc tgtaacccat tcacaaaggt gttctaggag    10800

cccattgaac atttgtttga atggaaggaa atgtccaatt tattttaatg aattactgat    10860

aaacagtgct ttgaccaggg gcctccaggc ctgagactga aggcacagtt taaccagtac    10920

acgggccagt gttaaatctt atgcagactg agacgaactt ttgtttattt ccacattatt    10980

aatggttcta ctaattttat ctaagggggc gcagagaaga aaaagtgggg aaaaaagaaa    11040

agataggaaa aaagaagcga cagaagaaga gaaaggctgc ccagaaaagg aaaaactagt    11100

tatctgccac ctcgagatgg accacagttc acttgctctc ggcgctttgt aaatttgctc    11160

gatcctcctc caggacagac ccccatgcag actgggcagg ggctcagact tccgtggggg    11220

agcagtgctt tgctgccctg ccagccacac cggcttctgt atttatgtgc tttttaaggc    11280

ccttgttggt ctgctaagtt atgaagaaag tagttgtgca gagactgggg cgggggtctg    11340

tgacgcggag cctgtgtgct caggactctg tccagaatag cctgggagct ccaggaatgc    11400

ccaggttgct gagcccccca gcccgccctc cacttcctct cttagaaggc ctgcgctcac    11460

tggggagctc accagctcca cacacttgca gtctgcattc ctgtggagac caggctgtgg    11520

ccacctggcc agtgtgcagg gcaacctgct agcccagcag aggtggcctc gccaggaagg    11580

gggtgtgcca cccctctgtg gccctcagga aaggtgaaaa ctgactgacc cttaggaatg    11640

ggccctggct ttttccaaat acccattgcc tttccctcca gcactctgcc acctgggaag    11700

gggcttcttc agcccctcct tcctgggttg tgggagtggc tttatcccca agcccgggtg    11760

ggtttctgca aactgtgtgg ggtgagcccg agggaatgct gcattctcag agagcagatg    11820

tggaaacact tctcagggag ctcctctttg ggcaattctc tttagagtct ttaaacgggt    11880

cccccacgtg gaggacagat gtgctatgga actttgcaag ggtcctgaat ccctggggat    11940

cccagcctgt cccctcccgc ctcctgcgtg atggcgtgtg ctccagctgc agggcacagc    12000

tgcctctgtc ctcattcatg ggaaatacct tatctgccta aagcaaatac cacttaagct    12060

ctaggaactt tcctgcaccc tccttccctg cccatgtaga tgtatgtgtg agattttttg    12120

gcaagtttct ctaatctgga ccgggaggat ggaagagcaa ggaccccatt tcagtagtgc    12180

tcggaaaaag gatgcgttga atttctcagc ccttctccac ctcacataaa cacccgccca    12240

ccctgcaccc ggatcctggg tcataatttt aataaatgca gaaagagaaa gtggttggag    12300

gatggagcac atggaattca ggagaaaacc cacaaagacc cctgcatgtc agacacaccc    12360

tgtcccggag cgtggtgtcc ccttgagctt taatgagctc cctgtgatca cagccatgcc    12420

ttctcctcgt tggggaggtg tcctaggatg cttcagccaa agacctttgt ttcccgctgc    12480

tatctctttt acctggacaa ctctcctggc ccacgttcct cttgccagca ctgggggtca    12540

caggcctgag ccctgggtac aggggtgccc tagtcttctg ccctccccac ctcttaaggc    12600

acagagctgt tgggtgggct gcctggggct gccatccttc ccgtggaagc cagtagccac    12660

tctagtccat gggactcttg acaaaagcgc cccgagaggg caaacctgtg cccccatact    12720

cgcctgcatt cttcggactc cacatgcagc agggctttgt gcctggggag gggtggccag    12780

tctgtcctgg tcagtatgaa aagctgttgg ccccctaggg acagagggcc cagctaaggc    12840

tgcctgagga tacaaactgc ttgctatccc actcctgggg agcagggtct gcagggactg    12900

agagtgggtc ccaccttgag aacgcatgca aggtccgtcc tgtcttgatg tcttgatgtg    12960

actgtatgtg ccctgggggc tcactgtggt ttacaagtgg cttgtgaagc tcctgggagc    13020

aggtggtaca cccagtgctg aagacagggt cgccgtggaa gagcgaagag cctgaccggg    13080

attcctggtg ggttgaaact aggaagtgct cacaccagtc agagccaaat gaggggtgcg    13140

ctatggtcac tgctctgtcc agcatgcgtt cctcctggga ggtcctggcc acctgtgcac    13200

ccacccctgt gccacctcca gcagtcccac ctggggccac ctacggtggc atggcccctg    13260

gctgagaggc cccgagggcg aagggttact ggaagccacg aaagtgcctc ttgggacagc    13320

cgaggccagg atgcagggca gcagcatcct gagcctcagc cccacgccgg tgccgggtaa    13380

gcagtgtgcc ctgtccccgt cgtatgacca ctctgatggg cctctctgtg ccttcgtgcg    13440

tctgccacgc ccagtgcttg ccacgtgtct gtcctctgct ttctgccatc catgggtccc    13500

tccgcttcag cctggctgcg tctcgcactc ccctcccgtc tgttgtcgca gggcctctga    13560

agggagatgc atggccaagg tggcaacttg gaagtaggga ttggccccag ggcctccgcg    13620

caggccgctg tcctgctgga gctggctggg tgtgggggga acctgcctta atggtgtttc    13680

cctctgttct tgtcaacagg aggttcaaga tgtgagaggg tcagacgcct gaggaaccct    13740

tacagtagga gcccagctct gaaaccagtg ttagggaagg gcctgccaca gcctcccctg    13800

ccagggcagg gccccaggca ttgccaaggg ctttgttttg cacactttgc catattttca    13860

ccatttgatt atgtagcaaa atacatgaca tttatttttc atttagtttg attattcagt    13920

gtcactggcg acacgtagca gcttagacta aggccattat tgtacttgcc ttattagagt    13980

gtctttccac ggagccactc ctctgactca gggctcctgg gttttgtatt ctctgagctg    14040

tgcaggtggg gagactgggc tgagggagcc tggccccatg gtcagcccta gggtggagag    14100

ccaccaagag ggacgcctgg gggtgccagg accagtcaac ctgggcaaag cctagtgaag    14160

gcttctctct gtgggatggg atggtggagg gccacatggg aggctcaccc ccttctccat    14220

ccacatggga gccgggtctg cctcttctgg gagggcagca gggctaccct gagctgaggc    14280

agcagtgtga ggccagggca gagtgagacc cagccctcat cccgagcacc tccacatcct    14340

ccacgttctg ctcatcattc tctgtctcat ccatcatcat gtgtgtccac gactgtctcc    14400

atggccccgc aaaaggactc tcaggaccaa agctttcatg taaactgtgc accaagcagg    14460

aaatgaaaat gtcttgtgtt acctgaaaac actgtgcaca tctgtgtctt gtttggaata    14520

ttgtccattg tccaatccta tgtttttgtt caaagccagc gtcctcctct gtgaccaatg    14580

tcttgatgca tgcactgttc cccctgtgca gccgctgagc gaggagatgc tccttgggcc    14640

ctttgagtgc agtcctgatc agagccgtgg tcctttgggg tgaactacct tggttccccc    14700

actgatcaca aaaacatggt gggtccatgg gcagagccca agggaattcg gtgtgcacca    14760

gggttgaccc cagaggattg ctgccccatc agtgctccct cacatgtcag taccttcaaa    14820

ctagggccaa gcccagcact gcttgaggaa aacaagcatt cacaacttgt ttttggtttt    14880

taaaacccag tccacaaaat aaccaatcct ggacatgaag attctttccc aattcacatc    14940

taacctcatc ttcttcacca tttggcaatg ccatcatctc ctgccttcct cctgggccct    15000

ctctgctctg cgtgtcacct gtgcttcggg cccttcccac aggacatttc tctaagagaa    15060

caatgtgcta tgtgaagagt aagtcaacct gcctgacatt tggagtgttc cccttccact    15120

gagggcagtc gatagagctg tattaagcca cttaaaatgt tcacttttga caaaggcaag    15180

cacttgtggg tttttgtttt gtttttcatt cagtcttacg aatacttttg ccctttgatt    15240

aaagactcca gttaaaaaaa attttaatga agaaagtgga aaacaaggaa gtcaaagcaa    15300

ggaaactatg taacatgtag gaagtaggaa gtaaattata gtgatgtaat cttgaattgt    15360

aactgttctt gaatttaata atctgtaggg taattagtaa catgtgttaa gtattttcat    15420

aagtatttca aattggagct tcatggcaga aggcaaaccc atcaacaaaa attgtccctt    15480

aaacaaaaat taaaatcctc aatccagcta tgttatattg aaaaaataga gcctgaggga    15540

tctttactag ttataaagat acagaactct ttcaaaacct tttgaaatta acctctcact    15600

ataccagtat aattgagttt tcagtggggc agtcattatc caggtaatcc aagatatttt    15660

aaaatctgtc acgtagaact tggatgtacc tgcccccaat ccatgaacca agaccattga    15720

attcttggtt gaggaaacaa acatgaccct aaatcttgac tacagtcagg aaaggaatca    15780

tttctatttc tcctccatgg gagaaaatag ataagagtag aaactgcagg gaaaattatt    15840

tgcataacaa ttcctctact aacaatcagc tccttcctgg agactgccca gctaaagcaa    15900

tatgcattta aatacagtct tccatttgca agggaaaagt ctcttgtaat ccgaatctct    15960

ttttgctttc gaactgctag tcaagtgcgt ccacgagctg tttactaggg atccctcatc    16020

tgtccctccg ggacctggtg ctgcctctac ctgacactcc cttgggctcc ctgtaacctc    16080

ttcagaggcc ctcgctgcca gctctgtatc aggacccaga ggaaggggcc agaggctcgt    16140

tgactggctg tgtgttggga ttgagtctgt gccacgtgtt tgtgctgtgg tgtgtccccc    16200

tctgtccagg cactgagata ccagcgagga ggctccagag ggcactctgc ttgttattag    16260

agattacctc ctgagaaaaa aggttccgct tggagcagag gggctgaata gcagaaggtt    16320

gcacctcccc caaccttaga tgttctaagt ctttccattg gatctcattg gacccttcca    16380

tggtgtgatc gtctgactgg tgttatcacc gtgggctccc tgactgggag ttgatcgcct    16440

ttcccaggtg ctacaccctt ttccagctgg atgagaattt gagtgctctg atccctctac    16500

agagcttccc tgactcattc tgaaggagcc ccattcctgg gaaatattcc ctagaaactt    16560

ccaaatcccc taagcagacc actgataaaa ccatgtagaa aatttgttat tttgcaacct    16620

cgctggactc tcagtctctg agcagtgaat gattcagtgt taaatgtgat gaatactgta    16680

ttttgtattg tttcaattgc atctcccaga taatgtgaaa atggtccagg agaaggccaa    16740

ttcctatacg cagcgtgctt taaaaaataa ataagaaaca actctttgag aaacaacaat    16800

ttctactttg aagtcatacc aatgaaaaaa tgtatatgca cttataattt tcctaataaa    16860

gttctgtact caaatgtagc caccaacagt ttgaaattag tgttactact tggaattttc    16920

tggacgtgct ttttttcccc acaaacccaa aactgagggt tgtgtaatcc tggctacagt    16980

ggttcatgga aaacagggca ttgtaatcat gctaatcaca gctgagaatt ctggaggcat    17040

acttgcctct tctggacagc tgatccttag cagggaaagg tgctcccttt tctctgagtg    17100

tctttgattt tgctagaatt gcttctgaaa ggccagcctg tcctccactc cacaagggat    17160

ggttttgtgc aagggtctca ggtatttctt gacagctgtg aggagggaag cttccactct    17220

gcccttctca gtcctgggag aatgcaacag aggtctggcc ctgatggtaa ttgctgagga    17280

ccagcactct gtgtgtttcc tgcactgcac agagaccttg ctggaagcca gacacgattc    17340

tctcacctag caatggctag ccagcactgt cctggacatg gggcatagga gatgagccca    17400

gcagacaggt tctggtcctc acagaggtca gcccttaaca ctctctagca cattctctgt    17460

catccacagt caactttgtt agaaaggaga gtcagcacaa aagttccgaa tgtctgagtc    17520

agattgtccg gtcctccaag ccctcttccc cattggtcca gatgtgatca catcatccca    17580

tgccaaatct tcccatgact taatgggatg gccgtcatgt gggtgctaag ctgcagatgg    17640

actggggaag gaagaagggt tagagcaggc cgggaagggc agcgtggtgt caggggacct    17700

gtgcaggtgt gaagatcagt agactggggc ttgcgtccca ttcactctct gctccctctg    17760

tgatttgaga tgcatccctt gatctctctg agttccagtc tcccagctgc aacactgaag    17820

cttattactg ccaacggtca agaggattag actgggagag tgtgtggaag aagctagctt    17880

ttgagggaca ggacaaagcc cgcccctcca ccctgaaagt tccccatttt gctccctctc    17940

tccacctcct gtttcctgag gtccacagag ctagaataag acccacatct gcctctgctg    18000

agccccttaa caaagctcag agaccaaggg agcaggaagt gacctggaag ctgagcctgc    18060

ccctcagcta aaggatgggg agaagtcact gggtcgcatc ccctgtatct ccggcacacc    18120

acactgctat cctagcactg ggaatcgaca atgggccaac ccttcaaaat gacctggcat    18180

cagaaagaaa gcctgagccc tggcatgctt gcattctccc ctcatttact tggccaacaa    18240

cagctgtgat gcctctcctg caccgcagga gtgtggggag caagacacac tcactctaat    18300

tccatgaagc ctgcagtctg gcggctgccg tgtgagaagt gggtattttc atagattgtg    18360

gtgcattcag gcatcaggga agcgtaaaac agaaaagacc cctaacttag gcatcagtaa    18420

ggatttgctt aaaaagcgct ggtgaaggtg agacctgaga aaagtggatt ctttggggag    18480

gtggtctact gagcccatga gggctggcat ggagagccca ggtggtatcc tcctgtgaat    18540

tggaaagggg gcttattcta gaagccggag gtgtagctca cacagggagt ctggcatggg    18600

gggcacaggg cactgggttt cagcttcctt attcccatca cttgtgggag gcacaaacac    18660

agctgagaaa gctggacccc cacggtgatg gggtcccctc agcacggctg attgcatgga    18720

gtggacactg gatgcatatt gcaggccgat ctgattttct gtcacaggag tacaaggctg    18780

tgattcaaca gcatcgggct ttgctccctt tctctgtg                            18818


