                         SEQUENCE LISTING

<110>  The Centre for Drug Research and Development
       The University of British Columbia
       University of Copenhagen
 
<120>  ANTI-PODOCALYXIN ANTIBODIES AND METHODS OF USING THE SAME

<130>  V810792WO

<140>  PCT/CA2016/051145
<141>  2016-09-30

<150>  62/236,130
<151>  2015-10-01

<150>  62/244,644
<151>  2015-10-21

<150>  62/291,262
<151>  2016-02-04

<160>  84    

<170>  PatentIn version 3.5

<210>  1
<211>  1593
<212>  DNA
<213>  Artificial sequence

<220>
<223>  scFv_VH_GGGGS_VL_CAR

<400>  1
atggagacgg gactcaggtg gctgcttctt gtcgccgtcc tgaagggggt gcagtgccag       60

agccttgaag aaagcggcgg aagactggtc acgcctggga ctccgctgac actgacttgc      120

acggcttccg gattttcact cagtggatac caaatgaact gggttaggca agccccaggg      180

aagggtctcg aatggatcgg ctatatatgg agtgatggag gcaccgatta tgcctcctgg      240

gctaagggac gcttcactat atccaagacc tccagtacta cagtggactt gaaaatgaca      300

tctcttacga cagaggacac cgccacctac ttctgcgcaa gagaggggta ctggctgggc      360

gcctttgacc catggggccc cgggaccctt gtgaccgtga gttccggggg aggtgggtcc      420

ggcgggggcg gcagtggagg cggcgggtct gccgtcctta ctcaaacacc aagccccgtg      480

tccgccgcag ttggcgctac tgttagcgtc agctgccaga gttcccagtc agtgcatcac      540

aagaacgacc ttgcatggtt tcagcagaag cccgggcaac cacccaagct cctcatttat      600

tatacaagta ctctggccag tggggtgcca tcccgcttca aggggtcagg gtctgggacc      660

caatttacac tcactattag cgacctcgag tgtgacgacg ccgccacgta ttattgcgcc      720

ggagtgtacg aaggcagctc tgataaccgc gccttcggcg gtgggactga agtggttgtt      780

aaagagcaga agctgatcag cgaggaggac ctgaaccgga tccgtggggt caccgtctct      840

tcagcgctga gcaactccat catgtacttc agccacttcg tgccggtctt cctgccagcg      900

aagcccacca cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag      960

cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg     1020

gggctggacc cctttgggtt ttgggtgctg gtggtggttg gtggagtcct ggcttgctat     1080

agcttgctag taacagtggc ctttattatt ttctgggtga ggagtaagag gagcaggctc     1140

ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac     1200

cagccctatg ccccaccacg cgacttcgca gcctatcgct ccctcgagag agtgagagtg     1260

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac     1320

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1380

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     1440

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1500

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1560

gcccttcaca tgcaggccct gccccctcgc taa                                  1593


<210>  2
<211>  1605
<212>  DNA
<213>  Artificial sequence

<220>
<223>  scFv_VL_GGGGS_VH_CAR

<400>  2
atggataccc gcgcacccac tcaactgctc gggctgctcc tgctgtggct ccctggggca       60

acatttgctg ccgtccttac tcaaacacca agccccgtgt ccgccgcagt tggcgctact      120

gttagcgtca gctgccagag ttcccagtca gtgcatcaca agaacgacct tgcatggttt      180

cagcagaagc ccgggcaacc acccaagctc ctcatttatt atacaagtac tctggccagt      240

ggggtgccat cccgcttcaa ggggtcaggg tctgggaccc aatttacact cactattagc      300

gacctcgagt gtgacgacgc cgccacgtat tattgcgccg gagtgtacga aggcagctct      360

gataaccgcg ccttcggcgg tgggactgaa gtggttgtta aagggggagg tgggtccggc      420

gggggcggca gtggaggcgg cgggtctcag tcccttgagg agtctggggg tagacttgtg      480

accccgggaa caccactgac tctgacgtgt accgcgtctg gcttctccct gagtggctac      540

caaatgaact gggtgaggca ggctcctgga aaaggactcg agtggattgg ctatatctgg      600

tccgacggtg gcaccgacta tgccagctgg gctaagggaa gatttacaat ctcaaaaacc      660

agcagcacca cagtggacct caaaatgacc agcctcacta cagaagatac cgccacgtat      720

ttctgtgcca gagagggata ttggcttggg gcttttgacc catgggggcc tgggaccctc      780

gtcaccgtga gttcagagca gaagctgatc agcgaggagg acctgaaccg gatccgtggg      840

gtcaccgtct cttcagcgct gagcaactcc atcatgtact tcagccactt cgtgccggtc      900

ttcctgccag cgaagcccac cacgacgcca gcgccgcgac caccaacacc ggcgcccacc      960

atcgcgtcgc agcccctgtc cctgcgccca gaggcgtgcc ggccagcggc ggggggcgca     1020

gtgcacacga gggggctgga cccctttggg ttttgggtgc tggtggtggt tggtggagtc     1080

ctggcttgct atagcttgct agtaacagtg gcctttatta ttttctgggt gaggagtaag     1140

aggagcaggc tcctgcacag tgactacatg aacatgactc cccgccgccc cgggcccacc     1200

cgcaagcatt accagcccta tgccccacca cgcgacttcg cagcctatcg ctccctcgag     1260

agagtgagag tgaagttcag caggagcgca gacgcccccg cgtaccagca gggccagaac     1320

cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga     1380

cgtggccggg accctgagat ggggggaaag ccgagaagga agaaccctca ggaaggcctg     1440

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc     1500

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag     1560

gacacctacg acgcccttca catgcaggcc ctgccccctc gctaa                     1605


<210>  3
<211>  2220
<212>  DNA
<213>  Artificial sequence

<220>
<223>  scFab_VL_CL_GGGGS_VH_CH1_CAR

<400>  3
atggataccc gcgcacccac tcaactgctc gggctgctcc tgctgtggct ccctggggca       60

acatttgctg ccgtccttac tcaaacacca agccccgtgt ccgccgcagt tggcgctact      120

gttagcgtca gctgccagag ttcccagtca gtgcatcaca agaacgacct tgcatggttt      180

cagcagaagc ccgggcaacc acccaagctc ctcatttatt atacaagtac tctggccagt      240

ggggtgccat cccgcttcaa ggggtcaggg tctgggaccc aatttacact cactattagc      300

gacctcgagt gtgacgacgc cgccacgtat tattgcgccg gagtgtacga aggcagctct      360

gataaccgcg ccttcggcgg tgggactgaa gtggttgtta aacgcacagt cgcagccccc      420

tccgtgttta tcttccctcc tagcgacgaa caactgaaga gcggaacagc cagcgtcgta      480

tgtttgctca ataacttcta tccaagggaa gccaaagtgc agtggaaagt cgataatgca      540

ctccagagcg gcaatagcca ggaaagtgta actgagcagg acagcaaaga tagcacctat      600

agcctgagct caaccctgac actgtcaaaa gcagattacg agaaacacaa ggtttacgcg      660

tgcgaagtga ctcatcaagg gttgtccagt cccgtgacaa aaagcttcaa tcgaggcgag      720

tgtggcgggg gcggtagcgg cggaggtggc agtggtggtg gcggctcaca gtctctggag      780

gaaagcggag gcaggctggt gaccccaggt acacccctga ccctcacctg taccgccagc      840

ggctttagcc tttctgggta ccagatgaat tgggtacgac aggcccctgg gaagggtctg      900

gagtggatag gttatatctg gtctgatggg ggcaccgatt acgcaagctg ggcgaagggc      960

agattcacta tcagcaaaac ttccagcacc accgtagatc tgaaaatgac cagtctgaca     1020

acagaagata ctgccactta tttttgcgcc agggaaggat actggctggg cgccttcgat     1080

ccttggggcc ccggtacgct ggtaactgtc tcatccgcat ccacgaaggg accttctgtg     1140

ttccctttgg ctccaagctc caaaagcaca agcggaggaa ccgcagcgct tggctgtttg     1200

gttaaggatt acttccccga acctgtgact gtgtcatgga actctggggc gcttaccagc     1260

ggcgtccaca catttccagc agttctgcag tctagtgggc tttacagtct gtcatctgta     1320

gtgactgtgc cttcttccag cctcgggacc cagacctaca tctgcaatgt caatcacaag     1380

ccatccaaca ctaaagtgga taagagagtg gagcagaagc tgatcagcga ggaggacctg     1440

aaccggatcc gtggggtcac cgtctcttca gcgctgagca actccatcat gtacttcagc     1500

cacttcgtgc cggtcttcct gccagcgaag cccaccacga cgccagcgcc gcgaccacca     1560

acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc gcccagaggc gtgccggcca     1620

gcggcggggg gcgcagtgca cacgaggggg ctggacccct ttgggttttg ggtgctggtg     1680

gtggttggtg gagtcctggc ttgctatagc ttgctagtaa cagtggcctt tattattttc     1740

tgggtgagga gtaagaggag caggctcctg cacagtgact acatgaacat gactccccgc     1800

cgccccgggc ccacccgcaa gcattaccag ccctatgccc caccacgcga cttcgcagcc     1860

tatcgctccc tcgagagagt gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1920

cagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1980

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     2040

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     2100

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     2160

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgctaa     2220


<210>  4
<211>  783
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Podo447_scFv_VH_GGGGS_VL

<400>  4
atggagacgg gactcaggtg gctgcttctt gtcgccgtcc tgaagggggt gcagtgccag       60

agccttgaag aaagcggcgg aagactggtc acgcctggga ctccgctgac actgacttgc      120

acggcttccg gattttcact cagtggatac caaatgaact gggttaggca agccccaggg      180

aagggtctcg aatggatcgg ctatatatgg agtgatggag gcaccgatta tgcctcctgg      240

gctaagggac gcttcactat atccaagacc tccagtacta cagtggactt gaaaatgaca      300

tctcttacga cagaggacac cgccacctac ttctgcgcaa gagaggggta ctggctgggc      360

gcctttgacc catggggccc cgggaccctt gtgaccgtga gttccggggg aggtgggtcc      420

ggcgggggcg gcagtggagg cggcgggtct gccgtcctta ctcaaacacc aagccccgtg      480

tccgccgcag ttggcgctac tgttagcgtc agctgccaga gttcccagtc agtgcatcac      540

aagaacgacc ttgcatggtt tcagcagaag cccgggcaac cacccaagct cctcatttat      600

tatacaagta ctctggccag tggggtgcca tcccgcttca aggggtcagg gtctgggacc      660

caatttacac tcactattag cgacctcgag tgtgacgacg ccgccacgta ttattgcgcc      720

ggagtgtacg aaggcagctc tgataaccgc gccttcggcg gtgggactga agtggttgtt      780

aaa                                                                    783


<210>  5
<211>  795
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Podo447_scFv_VL_GGGGS_VH

<400>  5
atggataccc gcgcacccac tcaactgctc gggctgctcc tgctgtggct ccctggggca       60

acatttgctg ccgtccttac tcaaacacca agccccgtgt ccgccgcagt tggcgctact      120

gttagcgtca gctgccagag ttcccagtca gtgcatcaca agaacgacct tgcatggttt      180

cagcagaagc ccgggcaacc acccaagctc ctcatttatt atacaagtac tctggccagt      240

ggggtgccat cccgcttcaa ggggtcaggg tctgggaccc aatttacact cactattagc      300

gacctcgagt gtgacgacgc cgccacgtat tattgcgccg gagtgtacga aggcagctct      360

gataaccgcg ccttcggcgg tgggactgaa gtggttgtta aagggggagg tgggtccggc      420

gggggcggca gtggaggcgg cgggtctcag tcccttgagg agtctggggg tagacttgtg      480

accccgggaa caccactgac tctgacgtgt accgcgtctg gcttctccct gagtggctac      540

caaatgaact gggtgaggca ggctcctgga aaaggactcg agtggattgg ctatatctgg      600

tccgacggtg gcaccgacta tgccagctgg gctaagggaa gatttacaat ctcaaaaacc      660

agcagcacca cagtggacct caaaatgacc agcctcacta cagaagatac cgccacgtat      720

ttctgtgcca gagagggata ttggcttggg gcttttgacc catgggggcc tgggaccctc      780

gtcaccgtga gttca                                                       795


<210>  6
<211>  1410
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Podo447_scFab_VL_CL_GGGGS_VH_CH1

<400>  6
atggataccc gcgcacccac tcaactgctc gggctgctcc tgctgtggct ccctggggca       60

acatttgctg ccgtccttac tcaaacacca agccccgtgt ccgccgcagt tggcgctact      120

gttagcgtca gctgccagag ttcccagtca gtgcatcaca agaacgacct tgcatggttt      180

cagcagaagc ccgggcaacc acccaagctc ctcatttatt atacaagtac tctggccagt      240

ggggtgccat cccgcttcaa ggggtcaggg tctgggaccc aatttacact cactattagc      300

gacctcgagt gtgacgacgc cgccacgtat tattgcgccg gagtgtacga aggcagctct      360

gataaccgcg ccttcggcgg tgggactgaa gtggttgtta aacgcacagt cgcagccccc      420

tccgtgttta tcttccctcc tagcgacgaa caactgaaga gcggaacagc cagcgtcgta      480

tgtttgctca ataacttcta tccaagggaa gccaaagtgc agtggaaagt cgataatgca      540

ctccagagcg gcaatagcca ggaaagtgta actgagcagg acagcaaaga tagcacctat      600

agcctgagct caaccctgac actgtcaaaa gcagattacg agaaacacaa ggtttacgcg      660

tgcgaagtga ctcatcaagg gttgtccagt cccgtgacaa aaagcttcaa tcgaggcgag      720

tgtggcgggg gcggtagcgg cggaggtggc agtggtggtg gcggctcaca gtctctggag      780

gaaagcggag gcaggctggt gaccccaggt acacccctga ccctcacctg taccgccagc      840

ggctttagcc tttctgggta ccagatgaat tgggtacgac aggcccctgg gaagggtctg      900

gagtggatag gttatatctg gtctgatggg ggcaccgatt acgcaagctg ggcgaagggc      960

agattcacta tcagcaaaac ttccagcacc accgtagatc tgaaaatgac cagtctgaca     1020

acagaagata ctgccactta tttttgcgcc agggaaggat actggctggg cgccttcgat     1080

ccttggggcc ccggtacgct ggtaactgtc tcatccgcat ccacgaaggg accttctgtg     1140

ttccctttgg ctccaagctc caaaagcaca agcggaggaa ccgcagcgct tggctgtttg     1200

gttaaggatt acttccccga acctgtgact gtgtcatgga actctggggc gcttaccagc     1260

ggcgtccaca catttccagc agttctgcag tctagtgggc tttacagtct gtcatctgta     1320

gtgactgtgc cttcttccag cctcgggacc cagacctaca tctgcaatgt caatcacaag     1380

ccatccaaca ctaaagtgga taagagagtg                                      1410


<210>  7
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MYC tag

<400>  7
gagcagaagc tgatcagcga ggaggacctg                                        30


<210>  8
<211>  189
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CD8 hinge

<400>  8
tcagcgctga gcaactccat catgtacttc agccacttcg tgccggtctt cctgccagcg       60

aagcccacca cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag      120

cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg      180

gggctggac                                                              189


<210>  9
<211>  81
<212>  DNA
<213>  Artificial sequence

<220>
<223>   CD28 TM

<400>  9
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg       60

gcctttatta ttttctgggt g                                                 81


<210>  10
<211>  123
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CD28 IC

<400>  10
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc       60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tcc                                                                    123


<210>  11
<211>  339
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CD3z

<400>  11
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgctaa                             339


<210>  12
<211>  1395
<212>  DNA
<213>  Artificial sequence

<220>
<223>  podo447VH

<400>  12
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag       60

tcgctggagg agtccggggg tcgcctggtc acgcctggga cacccctgac actcacctgc      120

acagcctctg gattctccct cagtggctac cagatgaact gggtccgcca ggctccaggg      180

aaggggctgg agtggatcgg atatatttgg agtgatggtg gtacagacta cgcgagctgg      240

gcgaaaggcc gattcaccat ctccaaaacc tcgtcgacca cggtggatct gaaaatgacc      300

agtctgacaa ccgaggacac ggccacctat ttctgtgcca gggagggata ctggcttggt      360

gcttttgatc cctggggccc aggcaccctg gtcaccgtct cttcagctag caccaagggc      420

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      480

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      540

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      600

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      660

aatcacaagc ccagcaacac caaggtggac aagagagttg agcccaaatc ttgtgacaaa      720

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      780

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      840

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      900

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      960

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1020

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1080

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     1140

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1200

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1260

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1320

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1380

ctgtctccgg gtaaa                                                      1395


<210>  13
<211>  2388
<212>  DNA
<213>  Artificial sequence

<220>
<223>  podo447VH_hIgG1C_chimeric

<400>  13
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag       60

tcgctggagg agtccggggg tcgcctggtc acgcctggga cacccctgac actcacctgc      120

acagcctctg gattctccct cagtggctac cagatgaact gggtccgcca ggctccaggg      180

aaggggctgg agtggatcgg atatatttgg agtgatggtg gtacagacta cgcgagctgg      240

gcgaaaggcc gattcaccat ctccaaaacc tcgtcgacca cggtggatct gaaaatgacc      300

agtctgacaa ccgaggacac ggccacctat ttctgtgcca gggagggata ctggcttggt      360

gcttttgatc cctggggccc aggcaccctg gtcaccgtct cttcagctag caccaagggc      420

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      480

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      540

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      600

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      660

aatcacaagc ccagcaacac caaggtggac aagagagttg agcccaaatc ttgtgacaaa      720

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      780

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      840

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      900

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      960

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1020

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1080

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     1140

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1200

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1260

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1320

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1380

ctgtctccgg gtaaagctag caccaagggc ccatcggtct tccccctggc accctcctcc     1440

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa     1500

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct     1560

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc     1620

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac     1680

aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct     1740

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg     1800

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag     1860

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1920

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1980

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc     2040

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     2100

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     2160

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     2220

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     2280

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     2340

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaatga                  2388


<210>  14
<211>  402
<212>  DNA
<213>  Artificial sequence

<220>
<223>  podo447VL

<400>  14
atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc       60

acatttgccg ccgtgctgac ccagactcca tctcccgtgt ctgcagctgt gggagccaca      120

gtcagcgtca gttgccagtc cagtcagagt gtccatcata agaacgactt agcctggttt      180

cagcagaaac caggtcagcc tcccaagctc ctgatctatt atacatccac tctggcatct      240

ggggtcccat cacggttcaa gggcagtgga tctgggacac agttcactct caccatcagc      300

gacctggagt gtgacgatgc tgccacttac tactgtgcag gcgtttatga gggtagtagt      360

gataataggg ctttcggcgg agggaccgag gtggtggtca aa                         402


<210>  15
<211>  726
<212>  DNA
<213>  Artificial sequence

<220>
<223>  podo447VL_hIgkC_chimeric

<400>  15
atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc       60

acatttgccg ccgtgctgac ccagactcca tctcccgtgt ctgcagctgt gggagccaca      120

gtcagcgtca gttgccagtc cagtcagagt gtccatcata agaacgactt agcctggttt      180

cagcagaaac caggtcagcc tcccaagctc ctgatctatt atacatccac tctggcatct      240

ggggtcccat cacggttcaa gggcagtgga tctgggacac agttcactct caccatcagc      300

gacctggagt gtgacgatgc tgccacttac tactgtgcag gcgtttatga gggtagtagt      360

gataataggg ctttcggcgg agggaccgag gtggtggtca aacgtacggt ggctgcacca      420

tctgtcttca tcttcccgcc atctgatgag cagttgaaat ctggaactgc ctctgttgtg      480

tgcctgctga ataacttcta tcccagagag gccaaagtac agtggaaggt ggataacgcc      540

ctccaatcgg gtaactccca ggagagtgtc acagagcagg acagcaagga cagcacctac      600

agcctcagca gcaccctgac gctgagcaaa gcagactacg agaaacacaa agtctacgcc      660

tgcgaagtca cccatcaggg cctgagctcg cccgtcacaa agagcttcaa caggggagag      720

tgttag                                                                 726


<210>  16
<211>  530
<212>  PRT
<213>  Artificial sequence

<220>
<223>  scFv_VH_GGGGS_VL_CAR

<400>  16

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 
            20                  25                  30          


Gly Thr Pro Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser 
        35                  40                  45              


Gly Tyr Gln Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Tyr Ile Trp Ser Asp Gly Gly Thr Asp Tyr Ala Ser Trp 
65                  70                  75                  80  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp 
                85                  90                  95      


Leu Lys Met Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys 
            100                 105                 110         


Ala Arg Glu Gly Tyr Trp Leu Gly Ala Phe Asp Pro Trp Gly Pro Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Ala Val Leu Thr Gln Thr Pro Ser Pro Val 
145                 150                 155                 160 


Ser Ala Ala Val Gly Ala Thr Val Ser Val Ser Cys Gln Ser Ser Gln 
                165                 170                 175     


Ser Val His His Lys Asn Asp Leu Ala Trp Phe Gln Gln Lys Pro Gly 
            180                 185                 190         


Gln Pro Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Thr Leu Ala Ser Gly 
        195                 200                 205             


Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu 
    210                 215                 220                 


Thr Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala 
225                 230                 235                 240 


Gly Val Tyr Glu Gly Ser Ser Asp Asn Arg Ala Phe Gly Gly Gly Thr 
                245                 250                 255     


Glu Val Val Val Lys Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn 
            260                 265                 270         


Arg Ile Arg Gly Val Thr Val Ser Ser Ala Leu Ser Asn Ser Ile Met 
        275                 280                 285             


Tyr Phe Ser His Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr 
    290                 295                 300                 


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
305                 310                 315                 320 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
                325                 330                 335     


Val His Thr Arg Gly Leu Asp Pro Phe Gly Phe Trp Val Leu Val Val 
            340                 345                 350         


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
        355                 360                 365             


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
    370                 375                 380                 


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
385                 390                 395                 400 


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Leu Glu 
                405                 410                 415     


Arg Val Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
            420                 425                 430         


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
        435                 440                 445             


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
    450                 455                 460                 


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
465                 470                 475                 480 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
                485                 490                 495     


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
            500                 505                 510         


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
        515                 520                 525             


Pro Arg 
    530 


<210>  17
<211>  534
<212>  PRT
<213>  Artificial sequence

<220>
<223>  scFv_VL_GGGGS_VH_CAR

<400>  17

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Ala Val Leu Thr Gln Thr Pro Ser Pro 
            20                  25                  30          


Val Ser Ala Ala Val Gly Ala Thr Val Ser Val Ser Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Val His His Lys Asn Asp Leu Ala Trp Phe Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Thr Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Ala Gly Val Tyr Glu Gly Ser Ser Asp Asn Arg Ala Phe Gly Gly Gly 
        115                 120                 125             


Thr Glu Val Val Val Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val 
145                 150                 155                 160 


Thr Pro Gly Thr Pro Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser 
                165                 170                 175     


Leu Ser Gly Tyr Gln Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
            180                 185                 190         


Leu Glu Trp Ile Gly Tyr Ile Trp Ser Asp Gly Gly Thr Asp Tyr Ala 
        195                 200                 205             


Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr 
    210                 215                 220                 


Val Asp Leu Lys Met Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr 
225                 230                 235                 240 


Phe Cys Ala Arg Glu Gly Tyr Trp Leu Gly Ala Phe Asp Pro Trp Gly 
                245                 250                 255     


Pro Gly Thr Leu Val Thr Val Ser Ser Glu Gln Lys Leu Ile Ser Glu 
            260                 265                 270         


Glu Asp Leu Asn Arg Ile Arg Gly Val Thr Val Ser Ser Ala Leu Ser 
        275                 280                 285             


Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu Pro Ala 
    290                 295                 300                 


Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
305                 310                 315                 320 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
                325                 330                 335     


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Pro Phe Gly Phe Trp 
            340                 345                 350         


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
        355                 360                 365             


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
    370                 375                 380                 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
385                 390                 395                 400 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
                405                 410                 415     


Arg Ser Leu Glu Arg Val Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
            420                 425                 430         


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
        435                 440                 445             


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
    450                 455                 460                 


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
465                 470                 475                 480 


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
                485                 490                 495     


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
            500                 505                 510         


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
        515                 520                 525             


Gln Ala Leu Pro Pro Arg 
    530                 


<210>  18
<211>  739
<212>  PRT
<213>  Artificial sequence

<220>
<223>  scFab_VL_CL_GGGGS_VH_CH1_CAR

<400>  18

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Ala Val Leu Thr Gln Thr Pro Ser Pro 
            20                  25                  30          


Val Ser Ala Ala Val Gly Ala Thr Val Ser Val Ser Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Val His His Lys Asn Asp Leu Ala Trp Phe Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Thr Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Ala Gly Val Tyr Glu Gly Ser Ser Asp Asn Arg Ala Phe Gly Gly Gly 
        115                 120                 125             


Thr Glu Val Val Val Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
    130                 135                 140                 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
145                 150                 155                 160 


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
                165                 170                 175     


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
            180                 185                 190         


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
        195                 200                 205             


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
    210                 215                 220                 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
225                 230                 235                 240 


Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
            260                 265                 270         


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Gly Tyr Gln 
        275                 280                 285             


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
    290                 295                 300                 


Tyr Ile Trp Ser Asp Gly Gly Thr Asp Tyr Ala Ser Trp Ala Lys Gly 
305                 310                 315                 320 


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
                325                 330                 335     


Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Glu 
            340                 345                 350         


Gly Tyr Trp Leu Gly Ala Phe Asp Pro Trp Gly Pro Gly Thr Leu Val 
        355                 360                 365             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    370                 375                 380                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
385                 390                 395                 400 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                405                 410                 415     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            420                 425                 430         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        435                 440                 445             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    450                 455                 460                 


Lys Val Asp Lys Arg Val Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
465                 470                 475                 480 


Asn Arg Ile Arg Gly Val Thr Val Ser Ser Ala Leu Ser Asn Ser Ile 
                485                 490                 495     


Met Tyr Phe Ser His Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr 
            500                 505                 510         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        515                 520                 525             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    530                 535                 540                 


Ala Val His Thr Arg Gly Leu Asp Pro Phe Gly Phe Trp Val Leu Val 
545                 550                 555                 560 


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
                565                 570                 575     


Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
            580                 585                 590         


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
        595                 600                 605             


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Leu 
    610                 615                 620                 


Glu Arg Val Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
625                 630                 635                 640 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                645                 650                 655     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            660                 665                 670         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        675                 680                 685             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    690                 695                 700                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
705                 710                 715                 720 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                725                 730                 735     


Pro Pro Arg 
            


<210>  19
<211>  261
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Podo447_scFv_VH_GGGGS_VL

<400>  19

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 
            20                  25                  30          


Gly Thr Pro Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser 
        35                  40                  45              


Gly Tyr Gln Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Tyr Ile Trp Ser Asp Gly Gly Thr Asp Tyr Ala Ser Trp 
65                  70                  75                  80  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp 
                85                  90                  95      


Leu Lys Met Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys 
            100                 105                 110         


Ala Arg Glu Gly Tyr Trp Leu Gly Ala Phe Asp Pro Trp Gly Pro Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Ala Val Leu Thr Gln Thr Pro Ser Pro Val 
145                 150                 155                 160 


Ser Ala Ala Val Gly Ala Thr Val Ser Val Ser Cys Gln Ser Ser Gln 
                165                 170                 175     


Ser Val His His Lys Asn Asp Leu Ala Trp Phe Gln Gln Lys Pro Gly 
            180                 185                 190         


Gln Pro Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Thr Leu Ala Ser Gly 
        195                 200                 205             


Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu 
    210                 215                 220                 


Thr Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala 
225                 230                 235                 240 


Gly Val Tyr Glu Gly Ser Ser Asp Asn Arg Ala Phe Gly Gly Gly Thr 
                245                 250                 255     


Glu Val Val Val Lys 
            260     


<210>  20
<211>  265
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Podo447_scFv_VL_GGGGS_VH

<400>  20

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Ala Val Leu Thr Gln Thr Pro Ser Pro 
            20                  25                  30          


Val Ser Ala Ala Val Gly Ala Thr Val Ser Val Ser Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Val His His Lys Asn Asp Leu Ala Trp Phe Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Thr Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Ala Gly Val Tyr Glu Gly Ser Ser Asp Asn Arg Ala Phe Gly Gly Gly 
        115                 120                 125             


Thr Glu Val Val Val Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val 
145                 150                 155                 160 


Thr Pro Gly Thr Pro Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser 
                165                 170                 175     


Leu Ser Gly Tyr Gln Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
            180                 185                 190         


Leu Glu Trp Ile Gly Tyr Ile Trp Ser Asp Gly Gly Thr Asp Tyr Ala 
        195                 200                 205             


Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr 
    210                 215                 220                 


Val Asp Leu Lys Met Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr 
225                 230                 235                 240 


Phe Cys Ala Arg Glu Gly Tyr Trp Leu Gly Ala Phe Asp Pro Trp Gly 
                245                 250                 255     


Pro Gly Thr Leu Val Thr Val Ser Ser 
            260                 265 


<210>  21
<211>  470
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Podo447_scFab_VL_CL_GGGGS_VH_CH1

<400>  21

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Ala Val Leu Thr Gln Thr Pro Ser Pro 
            20                  25                  30          


Val Ser Ala Ala Val Gly Ala Thr Val Ser Val Ser Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Val His His Lys Asn Asp Leu Ala Trp Phe Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Thr Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Ala Gly Val Tyr Glu Gly Ser Ser Asp Asn Arg Ala Phe Gly Gly Gly 
        115                 120                 125             


Thr Glu Val Val Val Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
    130                 135                 140                 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
145                 150                 155                 160 


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
                165                 170                 175     


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
            180                 185                 190         


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
        195                 200                 205             


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
    210                 215                 220                 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
225                 230                 235                 240 


Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
            260                 265                 270         


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Gly Tyr Gln 
        275                 280                 285             


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
    290                 295                 300                 


Tyr Ile Trp Ser Asp Gly Gly Thr Asp Tyr Ala Ser Trp Ala Lys Gly 
305                 310                 315                 320 


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
                325                 330                 335     


Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Glu 
            340                 345                 350         


Gly Tyr Trp Leu Gly Ala Phe Asp Pro Trp Gly Pro Gly Thr Leu Val 
        355                 360                 365             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    370                 375                 380                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
385                 390                 395                 400 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                405                 410                 415     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            420                 425                 430         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        435                 440                 445             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    450                 455                 460                 


Lys Val Asp Lys Arg Val 
465                 470 


<210>  22
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MYC tag

<400>  22

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  23
<211>  63
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD8 hinge

<400>  23

Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val 
1               5                   10                  15      


Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            20                  25                  30          


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        35                  40                  45              


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    50                  55                  60              


<210>  24
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD28 TM

<400>  24

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  25
<211>  41
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD28 IC

<400>  25

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  26
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD3z

<400>  26

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  27
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  podo447VH

<400>  27

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 
            20                  25                  30          


Gly Thr Pro Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser 
        35                  40                  45              


Gly Tyr Gln Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Tyr Ile Trp Ser Asp Gly Gly Thr Asp Tyr Ala Ser Trp 
65                  70                  75                  80  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp 
                85                  90                  95      


Leu Lys Met Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys 
            100                 105                 110         


Ala Arg Glu Gly Tyr Trp Leu Gly Ala Phe Asp Pro Trp Gly Pro Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ser 
    130                 135 


<210>  28
<211>  465
<212>  PRT
<213>  Artificial sequence

<220>
<223>  podo447VH_hIgG1C_chimeric

<400>  28

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 
            20                  25                  30          


Gly Thr Pro Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser 
        35                  40                  45              


Gly Tyr Gln Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Tyr Ile Trp Ser Asp Gly Gly Thr Asp Tyr Ala Ser Trp 
65                  70                  75                  80  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp 
                85                  90                  95      


Leu Lys Met Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys 
            100                 105                 110         


Ala Arg Glu Gly Tyr Trp Leu Gly Ala Phe Asp Pro Trp Gly Pro Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
    130                 135                 140                 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
145                 150                 155                 160 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
                165                 170                 175     


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
            180                 185                 190         


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
        195                 200                 205             


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
    210                 215                 220                 


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
225                 230                 235                 240 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        275                 280                 285             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
    370                 375                 380                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460                 


Lys 
465 


<210>  29
<211>  134
<212>  PRT
<213>  Artificial sequence

<220>
<223>  podo447VL

<400>  29

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Ala Val Leu Thr Gln Thr Pro Ser Pro 
            20                  25                  30          


Val Ser Ala Ala Val Gly Ala Thr Val Ser Val Ser Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Val His His Lys Asn Asp Leu Ala Trp Phe Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Thr Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Ala Gly Val Tyr Glu Gly Ser Ser Asp Asn Arg Ala Phe Gly Gly Gly 
        115                 120                 125             


Thr Glu Val Val Val Lys 
    130                 


<210>  30
<211>  241
<212>  PRT
<213>  Artificial sequence

<220>
<223>  podo447VL_hIgkC_chimeric

<400>  30

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Ala Val Leu Thr Gln Thr Pro Ser Pro 
            20                  25                  30          


Val Ser Ala Ala Val Gly Ala Thr Val Ser Val Ser Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Val His His Lys Asn Asp Leu Ala Trp Phe Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Thr Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Ala Gly Val Tyr Glu Gly Ser Ser Asp Asn Arg Ala Phe Gly Gly Gly 
        115                 120                 125             


Thr Glu Val Val Val Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
    130                 135                 140                 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
145                 150                 155                 160 


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
                165                 170                 175     


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
            180                 185                 190         


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
        195                 200                 205             


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
    210                 215                 220                 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
225                 230                 235                 240 


Cys 
    


<210>  31
<211>  557
<212>  PRT
<213>  human podocalyxin isoform 1

<400>  31

Met Arg Cys Ala Leu Ala Leu Ser Ala Leu Leu Leu Leu Leu Ser Thr 
1               5                   10                  15      


Pro Pro Leu Leu Pro Ser Ser Pro Ser Pro Ser Pro Ser Pro Ser Gln 
            20                  25                  30          


Asn Ala Thr Gln Thr Thr Thr Asp Ser Ser Asn Lys Thr Ala Pro Thr 
        35                  40                  45              


Pro Ala Ser Ser Val Thr Ile Met Ala Thr Asp Thr Ala Gln Gln Ser 
    50                  55                  60                  


Thr Val Pro Thr Ser Lys Ala Asn Glu Ile Leu Ala Ser Val Lys Ala 
65                  70                  75                  80  


Thr Thr Leu Gly Val Ser Ser Asp Ser Pro Gly Thr Thr Thr Leu Ala 
                85                  90                  95      


Gln Gln Val Ser Gly Pro Val Asn Thr Thr Val Ala Arg Gly Gly Gly 
            100                 105                 110         


Ser Gly Asn Pro Thr Thr Thr Ile Glu Ser Pro Lys Ser Thr Lys Ser 
        115                 120                 125             


Ala Asp Thr Thr Thr Val Ala Thr Ser Thr Ala Thr Ala Lys Pro Asn 
    130                 135                 140                 


Thr Thr Ser Ser Gln Asn Gly Ala Glu Asp Thr Thr Asn Ser Gly Gly 
145                 150                 155                 160 


Lys Ser Ser His Ser Val Thr Thr Asp Leu Thr Ser Thr Lys Ala Glu 
                165                 170                 175     


His Leu Thr Thr Pro His Pro Thr Ser Pro Leu Ser Pro Arg Gln Pro 
            180                 185                 190         


Thr Ser Thr His Pro Val Ala Thr Pro Thr Ser Ser Gly His Asp His 
        195                 200                 205             


Leu Met Lys Ile Ser Ser Ser Ser Ser Thr Val Ala Ile Pro Gly Tyr 
    210                 215                 220                 


Thr Phe Thr Ser Pro Gly Met Thr Thr Thr Leu Leu Glu Thr Val Phe 
225                 230                 235                 240 


His His Val Ser Gly Ala Gly Leu Glu Leu Leu Thr Ser Gly Asp Leu 
                245                 250                 255     


Pro Thr Leu Ala Ser Gln Ser Ala Gly Ile Thr Ala Ser Ser Val Ile 
            260                 265                 270         


Ser Gln Arg Thr Gln Gln Thr Ser Ser Gln Met Pro Ala Ser Ser Thr 
        275                 280                 285             


Ala Pro Ser Ser Gly Glu Thr Val Gln Pro Thr Ser Pro Ala Thr Ala 
    290                 295                 300                 


Leu Arg Thr Pro Thr Leu Pro Glu Thr Met Ser Ser Ser Pro Thr Ala 
305                 310                 315                 320 


Ala Ser Thr Thr His Arg Tyr Pro Lys Thr Pro Ser Pro Thr Val Ala 
                325                 330                 335     


His Glu Ser Asn Trp Ala Lys Cys Glu Asp Leu Glu Thr Gln Thr Gln 
            340                 345                 350         


Ser Glu Lys Gln Leu Val Ile Asn Leu Thr Gly Asn Thr Ile Cys Ala 
        355                 360                 365             


Gly Gly Ala Ser Asp Glu Lys Leu Ile Ser Leu Ile Cys Arg Ala Val 
    370                 375                 380                 


Lys Ala Thr Phe Asn Pro Ala Gln Asp Lys Cys Gly Ile Arg Leu Ala 
385                 390                 395                 400 


Ser Val Pro Gly Ser Gln Thr Val Val Val Lys Glu Ile Thr Ile His 
                405                 410                 415     


Thr Lys Leu Pro Ala Lys Asp Val Tyr Glu Arg Leu Lys Asp Lys Trp 
            420                 425                 430         


Asp Glu Leu Lys Glu Ala Gly Val Ser Asp Met Lys Gly Asp Gln Gly 
        435                 440                 445             


Pro Pro Glu Glu Ala Glu Asp Arg Phe Ser Met Pro Leu Ile Ile Thr 
    450                 455                 460                 


Ile Val Cys Met Ala Ser Phe Leu Leu Leu Val Ala Ala Leu Tyr Gly 
465                 470                 475                 480 


Cys Cys His Gln Arg Leu Ser Gln Arg Lys Asp Gln Gln Arg Leu Thr 
                485                 490                 495     


Glu Glu Leu Gln Thr Val Glu Asn Gly Tyr His Asp Asn Pro Thr Leu 
            500                 505                 510         


Glu Val Met Glu Thr Ser Ser Glu Met Gly Glu Lys Lys Val Val Ser 
        515                 520                 525             


Leu Asn Gly Glu Leu Gly Asp Ser Trp Ile Val Pro Leu Asp Asn Ile 
    530                 535                 540                 


Thr Lys Asp Asp Leu Asp Glu Glu Glu Asp Thr His Leu 
545                 550                 555         


<210>  32
<211>  526
<212>  PRT
<213>  human podocalyxin isoform 2

<400>  32

Met Arg Cys Ala Leu Ala Leu Ser Ala Leu Leu Leu Leu Leu Ser Thr 
1               5                   10                  15      


Pro Pro Leu Leu Pro Ser Ser Pro Ser Pro Ser Pro Ser Pro Ser Gln 
            20                  25                  30          


Asn Ala Thr Gln Thr Thr Thr Asp Ser Ser Asn Lys Thr Ala Pro Thr 
        35                  40                  45              


Pro Ala Ser Ser Val Thr Ile Met Ala Thr Asp Thr Ala Gln Gln Ser 
    50                  55                  60                  


Thr Val Pro Thr Ser Lys Ala Asn Glu Ile Leu Ala Ser Val Lys Ala 
65                  70                  75                  80  


Thr Thr Leu Gly Val Ser Ser Asp Ser Pro Gly Thr Thr Thr Leu Ala 
                85                  90                  95      


Gln Gln Val Ser Gly Pro Val Asn Thr Thr Val Ala Arg Gly Gly Gly 
            100                 105                 110         


Ser Gly Asn Pro Thr Thr Thr Ile Glu Ser Pro Lys Ser Thr Lys Ser 
        115                 120                 125             


Ala Asp Thr Thr Thr Val Ala Thr Ser Thr Ala Thr Ala Lys Pro Asn 
    130                 135                 140                 


Thr Thr Ser Ser Gln Asn Gly Ala Glu Asp Thr Thr Asn Ser Gly Gly 
145                 150                 155                 160 


Lys Ser Ser His Ser Val Thr Thr Asp Leu Thr Ser Thr Lys Ala Glu 
                165                 170                 175     


His Leu Thr Thr Pro His Pro Thr Ser Pro Leu Ser Pro Arg Gln Pro 
            180                 185                 190         


Thr Ser Thr His Pro Val Ala Thr Pro Thr Ser Ser Gly His Asp His 
        195                 200                 205             


Leu Met Lys Ile Ser Ser Ser Ser Ser Thr Val Ala Ile Pro Gly Tyr 
    210                 215                 220                 


Thr Phe Thr Ser Pro Gly Met Thr Thr Thr Leu Pro Ser Ser Val Ile 
225                 230                 235                 240 


Ser Gln Arg Thr Gln Gln Thr Ser Ser Gln Met Pro Ala Ser Ser Thr 
                245                 250                 255     


Ala Pro Ser Ser Gln Glu Thr Val Gln Pro Thr Ser Pro Ala Thr Ala 
            260                 265                 270         


Leu Arg Thr Pro Thr Leu Pro Glu Thr Met Ser Ser Ser Pro Thr Ala 
        275                 280                 285             


Ala Ser Thr Thr His Arg Tyr Pro Lys Thr Pro Ser Pro Thr Val Ala 
    290                 295                 300                 


His Glu Ser Asn Trp Ala Lys Cys Glu Asp Leu Glu Thr Gln Thr Gln 
305                 310                 315                 320 


Ser Glu Lys Gln Leu Val Ile Asn Ile Thr Gly Asn Thr Ile Cys Ala 
                325                 330                 335     


Gly Gly Ala Ser Asp Glu Lys Leu Ile Ser Leu Ile Cys Arg Ala Val 
            340                 345                 350         


Lys Ala Thr Phe Asn Pro Ala Gln Asp Lys Cys Gly Ile Arg Leu Ala 
        355                 360                 365             


Ser Val Pro Gly Ser Gln Thr Val Val Val Lys Glu Ile Thr Ile His 
    370                 375                 380                 


Thr Lys Leu Pro Ala Lys Asp Val Tyr Glu Arg Leu Lys Asp Lys Trp 
385                 390                 395                 400 


Asp Glu Leu Lys Glu Ala Gly Val Ser Asp Met Lys Leu Gly Asp Gln 
                405                 410                 415     


Gly Pro Pro Glu Glu Ala Glu Asp Arg Phe Ser Met Pro Leu Ile Ile 
            420                 425                 430         


Thr Ile Val Cys Met Ala Ser Phe Leu Leu Leu Val Ala Ala Leu Tyr 
        435                 440                 445             


Gly Cys Cys His Gln Arg Leu Ser Gln Arg Lys Asp Gln Gln Arg Leu 
    450                 455                 460                 


Thr Glu Glu Leu Gln Thr Val Glu Asn Gly Tyr His Asp Asn Pro Thr 
465                 470                 475                 480 


Leu Glu Val Met Glu Thr Ser Ser Glu Met Gln Glu Lys Lys Val Val 
                485                 490                 495     


Ser Leu Asn Gly Glu Leu Gly Asp Ser Trp Ile Val Pro Leu Asp Asn 
            500                 505                 510         


Ile Thr Lys Asp Asp Leu Asp Glu Glu Glu Asp Thr His Leu 
        515                 520                 525     


<210>  33
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Podo447_VH_CDR1_ IMGT

<400>  33

Gly Phe Ser Leu Ser Gly Tyr Gln 
1               5               


<210>  34
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Podo447_VH_CDR1_ Chotia

<400>  34

Gly Phe Ser Leu Ser Gly Tyr 
1               5           


<210>  35
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Podo447_VH_CDR1_ Kabat

<400>  35

Gly Tyr Gln Met Asn 
1               5   


<210>  36
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Podo447_VH_CDR2_ IMGT

<400>  36

Ile Trp Ser Asp Gly Gly Thr 
1               5           


<210>  37
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Podo447_VH_CDR2_ Chotia

<400>  37

Trp Ser Asp Gly Gly 
1               5   


<210>  38
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Podo447_VH_CDR2_ Kabat

<400>  38

Tyr Ile Trp Ser Asp Gly Gly Thr Asp Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  39
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Podo447_VH_CDR3_ IMGT

<400>  39

Ala Arg Glu Gly Tyr Trp Leu Gly Ala Phe Asp Pro 
1               5                   10          


<210>  40
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Podo447_VH_CDR3_ Chotia

<400>  40

Glu Gly Tyr Trp Leu Gly Ala Phe Asp Pro 
1               5                   10  


<210>  41
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Podo447_VH_CDR3_ Kabat

<400>  41

Glu Gly Tyr Trp Leu Gly Ala Phe Asp Pro 
1               5                   10  


<210>  42
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Podo447_Vk_CDR1_ IMGT

<400>  42

Gln Ser Val His His Lys Asn Asp 
1               5               


<210>  43
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Podo447_Vk_CDR1_ Chotia

<400>  43

Gln Ser Val His His Lys Asn Asp Leu Ala 
1               5                   10  


<210>  44
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Podo447_Vk_CDR1_ Kabat

<400>  44

Gln Ser Ser Gln Ser Val His His Lys Asn Asp Leu Ala 
1               5                   10              


<210>  45
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Podo447_Vk_CDR2_ IMGT

<400>  45

Tyr Thr Ser 
1           


<210>  46
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Podo447_Vk_CDR2_ Chotia

<400>  46

Tyr Thr Ser Leu Ala Ser 
1               5       


<210>  47
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Podo447_Vk_CDR2_ Kabat

<400>  47

Tyr Thr Ser Leu Ala Ser 
1               5       


<210>  48
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Podo447_Vk_CDR3_ IMGT

<400>  48

Ala Gly Val Tyr Glu Gly Ser Ser Asp Asn Arg Ala 
1               5                   10          


<210>  49
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Podo447_Vk_CDR3_ Chotia

<400>  49

Ala Gly Val Tyr Glu Gly Ser Ser Asp Asn Arg Ala 
1               5                   10          


<210>  50
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Podo447_Vk_CDR3_ Kabat

<400>  50

Ala Gly Val Tyr Glu Gly Ser Ser Asp Asn Arg Ala 
1               5                   10          


<210>  51
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Podo447_VH_CDR1_ IMGT

<400>  51
ggattctccc tcagtggcta ccag                                              24


<210>  52
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Podo447_VH_CDR1_ Chotia

<400>  52
ggattctccc tcagtggcta c                                                 21


<210>  53
<211>  9
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Podo447_VH_CDR1_ Kabat

<400>  53
ggctaccag                                                                9


<210>  54
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Podo447_VH_CDR2_ IMGT

<400>  54
atttggagtg atggtggtac a                                                 21


<210>  55
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Podo447_VH_CDR2_ Chotia

<400>  55
tggagtgatg gtggt                                                        15


<210>  56
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Podo447_VH_CDR2_ Kabat

<400>  56
tatatttgga gtgatggtgg tacagactac gcgagctggg cgaaaggc                    48


<210>  57
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Podo447_VH_CDR3_ IMGT

<400>  57
gccagggagg gatactggct tggtgctttt gatccc                                 36


<210>  58
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Podo447_VH_CDR3_ Chotia

<400>  58
gagggatact ggcttggtgc ttttgatccc                                        30


<210>  59
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Podo447_VH_CDR3_ Kabat

<400>  59
gagggatact ggcttggtgc ttttgatccc                                        30


<210>  60
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Podo447_Vk_CDR1_ IMGT

<400>  60
cagagtgtcc atcataagaa cgac                                              24


<210>  61
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Podo447_Vk_CDR1_ Chotia

<400>  61
cagtccagtc agagtgtcca tcataagaac gacttagcc                              39


<210>  62
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Podo447_Vk_CDR1_ Kabat

<400>  62
cagtccagtc agagtgtcca tcataagaac gacttagcc                              39


<210>  63
<211>  9
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Podo447_Vk_CDR2_ IMGT

<400>  63
tatacatcc                                                                9


<210>  64
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Podo447_Vk_CDR2_ Chotia

<400>  64
tatacatcca ctctggca                                                     18


<210>  65
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Podo447_Vk_CDR2_ Kabat

<400>  65
tatacatcca ctctggca                                                     18


<210>  66
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Podo447_Vk_CDR3_ IMGT

<400>  66
gcaggcgttt atgagggtag tagtgataat agggct                                 36


<210>  67
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Podo447_Vk_CDR3_ Chotia

<400>  67
gcaggcgttt atgagggtag tagtgataat agggct                                 36


<210>  68
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Podo447_Vk_CDR3_ Kabat

<400>  68
gcaggcgttt atgagggtag tagtgataat agggct                                 36


<210>  69
<211>  408
<212>  DNA
<213>  Artificial sequence

<220>
<223>  humanized_podo447VH

<400>  69
atggaatttg ggttgagttg ggtattcctg gtcgccatat tgaagggcgt gcaatgcgaa       60

gtacagcttg tagaatctgg ggggggtctc gttcaaccgg gtaggagttt gagactgagc      120

tgcacggcct ctggcttcag cttgtctgga taccaaatga actgggtgcg acaagcgccc      180

ggcaagggtt tggaatgggt gggttacatc tggagtgatg gcggaacgga ttacactgct      240

tccgtaaagg ggcgatttac catttccagg gacggtagca aaagtatcgc gtaccttcaa      300

atgaactccc tcaagacaga ggatacggct gtgtactact gcgcgaggga aggatattgg      360

ctcggggcat tcgacccatg gggtcaggga acctcagtca ccgtcagc                   408


<210>  70
<211>  136
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized_podo447VH

<400>  70

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Gly Tyr Gln Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Gly Tyr Ile Trp Ser Asp Gly Gly Thr Asp Tyr Thr Ala 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Ser Lys Ser Ile 
                85                  90                  95      


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Glu Gly Tyr Trp Leu Gly Ala Phe Asp Pro Trp Gly 
        115                 120                 125             


Gln Gly Thr Ser Val Thr Val Ser 
    130                 135     


<210>  71
<211>  1401
<212>  DNA
<213>  Artificial sequence

<220>
<223>  humanized_podo447VH_hIgG1C

<400>  71
atggaatttg ggttgagttg ggtattcctg gtcgccatat tgaagggcgt gcaatgcgaa       60

gtacagcttg tagaatctgg ggggggtctc gttcaaccgg gtaggagttt gagactgagc      120

tgcacggcct ctggcttcag cttgtctgga taccaaatga actgggtgcg acaagcgccc      180

ggcaagggtt tggaatgggt gggttacatc tggagtgatg gcggaacgga ttacactgct      240

tccgtaaagg ggcgatttac catttccagg gacggtagca aaagtatcgc gtaccttcaa      300

atgaactccc tcaagacaga ggatacggct gtgtactact gcgcgaggga aggatattgg      360

ctcggggcat tcgacccatg gggtcaggga acctcagtca ccgtcagcgc tagcaccaag      420

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      480

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      540

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      600

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      660

gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac      720

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc      780

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      840

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      900

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      960

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc     1020

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     1080

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1140

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1200

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1260

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1320

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1380

tccctgtctc cgggtaaatg a                                               1401


<210>  72
<211>  466
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized_podo447VH_hIgG1C

<400>  72

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Gly Tyr Gln Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Gly Tyr Ile Trp Ser Asp Gly Gly Thr Asp Tyr Thr Ala 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Ser Lys Ser Ile 
                85                  90                  95      


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Glu Gly Tyr Trp Leu Gly Ala Phe Asp Pro Trp Gly 
        115                 120                 125             


Gln Gly Thr Ser Val Thr Val Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  73
<211>  402
<212>  DNA
<213>  Artificial sequence

<220>
<223>  humanized_podo447VL6

<400>  73
atggacatgc gggttccagc gcagctcttg ggactcttgc tgttgtggtt gcccggtgcc       60

aggtgtgcgg cccagcttac acagagtccc tctcctttgt cagcttcagt tggtgatagg      120

gtgactataa cctgtcagag tagtcagtcc gttcaccaca agaacgacct cgcgtggtat      180

cagcagaagc ctggcaaagc gccgaaactg ctcatttact atacgtctac gttggcaagt      240

ggtgtcccct cacggttctc aggctccggt agcgggacag attttactct cacaatcagc      300

tcccttcagc ccgaagattt cgctacatat tattgtgctg gggtatatga ggggagttct      360

gataatcggg catttggggg cggcacgaag gtggagatta aa                         402


<210>  74
<211>  134
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized_podo447VL6

<400>  74

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys Ala Ala Gln Leu Thr Gln Ser Pro Ser Pro 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Val His His Lys Asn Asp Leu Ala Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Thr Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Ala Gly Val Tyr Glu Gly Ser Ser Asp Asn Arg Ala Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Val Glu Ile Lys 
    130                 


<210>  75
<211>  723
<212>  DNA
<213>  Artificial sequence

<220>
<223>  humanized_podo447VL6_hIgkC

<400>  75
atggacatgc gggttccagc gcagctcttg ggactcttgc tgttgtggtt gcccggtgcc       60

aggtgtgcgg cccagcttac acagagtccc tctcctttgt cagcttcagt tggtgatagg      120

gtgactataa cctgtcagag tagtcagtcc gttcaccaca agaacgacct cgcgtggtat      180

cagcagaagc ctggcaaagc gccgaaactg ctcatttact atacgtctac gttggcaagt      240

ggtgtcccct cacggttctc aggctccggt agcgggacag attttactct cacaatcagc      300

tcccttcagc ccgaagattt cgctacatat tattgtgctg gggtatatga ggggagttct      360

gataatcggg catttggggg cggcacgaag gtggagatta aacgtacggt ggctgcacca      420

tctgtcttca tcttcccgcc atctgatgag cagttgaaat ctggaactgc ctctgttgtg      480

tgcctgctga ataacttcta tcccagagag gccaaagtac agtggaaggt ggataacgcc      540

ctccaatcgg gtaactccca ggagagtgtc acagagcagg acagcaagga cagcacctac      600

agcctcagca gcaccctgac gctgagcaaa gcagactacg agaaacacaa agtctacgcc      660

tgcgaagtca cccatcaggg cctgagctcg cccgtcacaa agagcttcaa caggggagag      720

tgt                                                                    723


<210>  76
<211>  241
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized_podo447VL6_hIgkC

<400>  76

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys Ala Ala Gln Leu Thr Gln Ser Pro Ser Pro 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Val His His Lys Asn Asp Leu Ala Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Thr Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Ala Gly Val Tyr Glu Gly Ser Ser Asp Asn Arg Ala Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
    130                 135                 140                 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
145                 150                 155                 160 


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
                165                 170                 175     


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
            180                 185                 190         


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
        195                 200                 205             


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
    210                 215                 220                 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
225                 230                 235                 240 


Cys 
    


<210>  77
<211>  789
<212>  DNA
<213>  Artificial sequence

<220>
<223>  humanized_scFv_podo447VH_GGGGS_VL6

<400>  77
atggaatttg ggttgagttg ggtattcctg gtcgccatat tgaagggcgt gcaatgcgaa       60

gtacagcttg tagaatctgg ggggggtctc gttcaaccgg gtaggagttt gagactgagc      120

tgcacggcct ctggcttcag cttgtctgga taccaaatga actgggtgcg acaagcgccc      180

ggcaagggtt tggaatgggt gggttacatc tggagtgatg gcggaacgga ttacactgct      240

tccgtaaagg ggcgatttac catttccagg gacggtagca aaagtatcgc gtaccttcaa      300

atgaactccc tcaagacaga ggatacggct gtgtactact gcgcgaggga aggatattgg      360

ctcggggcat tcgacccatg gggtcaggga acctcagtca ccgtcagcgg gggaggtggg      420

tccggcgggg gcggcagtgg aggcggcggg tctgcggccc agcttacaca gagtccctct      480

cctttgtcag cttcagttgg tgatagggtg actataacct gtcagagtag tcagtccgtt      540

caccacaaga acgacctcgc gtggtatcag cagaagcctg gcaaagcgcc gaaactgctc      600

atttactata cgtctacgtt ggcaagtggt gtcccctcac ggttctcagg ctccggtagc      660

gggacagatt ttactctcac aatcagctcc cttcagcccg aagatttcgc tacatattat      720

tgtgctgggg tatatgaggg gagttctgat aatcgggcat ttgggggcgg cacgaaggtg      780

gagattaaa                                                              789


<210>  78
<211>  263
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized_scFv_podo447VH_GGGGS_VL6

<400>  78

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Gly Tyr Gln Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Gly Tyr Ile Trp Ser Asp Gly Gly Thr Asp Tyr Thr Ala 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Ser Lys Ser Ile 
                85                  90                  95      


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Glu Gly Tyr Trp Leu Gly Ala Phe Asp Pro Trp Gly 
        115                 120                 125             


Gln Gly Thr Ser Val Thr Val Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Ala Ala Gln Leu Thr Gln Ser Pro Ser 
145                 150                 155                 160 


Pro Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser 
                165                 170                 175     


Ser Gln Ser Val His His Lys Asn Asp Leu Ala Trp Tyr Gln Gln Lys 
            180                 185                 190         


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Thr Leu Ala 
        195                 200                 205             


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    210                 215                 220                 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
225                 230                 235                 240 


Cys Ala Gly Val Tyr Glu Gly Ser Ser Asp Asn Arg Ala Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Val Glu Ile Lys 
            260             


<210>  79
<211>  1599
<212>  DNA
<213>  Artificial sequence

<220>
<223>  humanized_scFv_podo447VH_GGGGS_VL6_CAR

<400>  79
atggaatttg ggttgagttg ggtattcctg gtcgccatat tgaagggcgt gcaatgcgaa       60

gtacagcttg tagaatctgg ggggggtctc gttcaaccgg gtaggagttt gagactgagc      120

tgcacggcct ctggcttcag cttgtctgga taccaaatga actgggtgcg acaagcgccc      180

ggcaagggtt tggaatgggt gggttacatc tggagtgatg gcggaacgga ttacactgct      240

tccgtaaagg ggcgatttac catttccagg gacggtagca aaagtatcgc gtaccttcaa      300

atgaactccc tcaagacaga ggatacggct gtgtactact gcgcgaggga aggatattgg      360

ctcggggcat tcgacccatg gggtcaggga acctcagtca ccgtcagcgg gggaggtggg      420

tccggcgggg gcggcagtgg aggcggcggg tctgcggccc agcttacaca gagtccctct      480

cctttgtcag cttcagttgg tgatagggtg actataacct gtcagagtag tcagtccgtt      540

caccacaaga acgacctcgc gtggtatcag cagaagcctg gcaaagcgcc gaaactgctc      600

atttactata cgtctacgtt ggcaagtggt gtcccctcac ggttctcagg ctccggtagc      660

gggacagatt ttactctcac aatcagctcc cttcagcccg aagatttcgc tacatattat      720

tgtgctgggg tatatgaggg gagttctgat aatcgggcat ttgggggcgg cacgaaggtg      780

gagattaaag agcagaagct gatcagcgag gaggacctga accggatccg tggggtcacc      840

gtctcttcag cgctgagcaa ctccatcatg tacttcagcc acttcgtgcc ggtcttcctg      900

ccagcgaagc ccaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg      960

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac     1020

acgagggggc tggacccctt tgggttttgg gtgctggtgg tggttggtgg agtcctggct     1080

tgctatagct tgctagtaac agtggccttt attattttct gggtgaggag taagaggagc     1140

aggctcctgc acagtgacta catgaacatg actccccgcc gccccgggcc cacccgcaag     1200

cattaccagc cctatgcccc accacgcgac ttcgcagcct atcgctccct cgagagagtg     1260

agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc     1320

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1380

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat     1440

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1500

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1560

tacgacgccc ttcacatgca ggccctgccc cctcgctaa                            1599


<210>  80
<211>  532
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized_scFv_podo447VH_GGGGS_VL6_CAR

<400>  80

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Gly Tyr Gln Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Gly Tyr Ile Trp Ser Asp Gly Gly Thr Asp Tyr Thr Ala 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Ser Lys Ser Ile 
                85                  90                  95      


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Glu Gly Tyr Trp Leu Gly Ala Phe Asp Pro Trp Gly 
        115                 120                 125             


Gln Gly Thr Ser Val Thr Val Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Ala Ala Gln Leu Thr Gln Ser Pro Ser 
145                 150                 155                 160 


Pro Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser 
                165                 170                 175     


Ser Gln Ser Val His His Lys Asn Asp Leu Ala Trp Tyr Gln Gln Lys 
            180                 185                 190         


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Thr Leu Ala 
        195                 200                 205             


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    210                 215                 220                 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
225                 230                 235                 240 


Cys Ala Gly Val Tyr Glu Gly Ser Ser Asp Asn Arg Ala Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Val Glu Ile Lys Glu Gln Lys Leu Ile Ser Glu Glu Asp 
            260                 265                 270         


Leu Asn Arg Ile Arg Gly Val Thr Val Ser Ser Ala Leu Ser Asn Ser 
        275                 280                 285             


Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu Pro Ala Lys Pro 
    290                 295                 300                 


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
305                 310                 315                 320 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
                325                 330                 335     


Gly Ala Val His Thr Arg Gly Leu Asp Pro Phe Gly Phe Trp Val Leu 
            340                 345                 350         


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
        355                 360                 365             


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
    370                 375                 380                 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
385                 390                 395                 400 


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                405                 410                 415     


Leu Glu Arg Val Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            420                 425                 430         


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        435                 440                 445             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    450                 455                 460                 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
465                 470                 475                 480 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                485                 490                 495     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            500                 505                 510         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        515                 520                 525             


Leu Pro Pro Arg 
    530         


<210>  81
<211>  798
<212>  DNA
<213>  Artificial sequence

<220>
<223>  humanized_scFv_podo447VL6_GGGGS_VH

<400>  81
atggacatgc gggttccagc gcagctcttg ggactcttgc tgttgtggtt gcccggtgcc       60

aggtgtgcgg cccagcttac acagagtccc tctcctttgt cagcttcagt tggtgatagg      120

gtgactataa cctgtcagag tagtcagtcc gttcaccaca agaacgacct cgcgtggtat      180

cagcagaagc ctggcaaagc gccgaaactg ctcatttact atacgtctac gttggcaagt      240

ggtgtcccct cacggttctc aggctccggt agcgggacag attttactct cacaatcagc      300

tcccttcagc ccgaagattt cgctacatat tattgtgctg gggtatatga ggggagttct      360

gataatcggg catttggggg cggcacgaag gtggagatta aagggggagg tgggtccggc      420

gggggcggca gtggaggcgg cgggtctgaa gtacagcttg tagaatctgg ggggggtctc      480

gttcaaccgg gtaggagttt gagactgagc tgcacggcct ctggcttcag cttgtctgga      540

taccaaatga actgggtgcg acaagcgccc ggcaagggtt tggaatgggt gggttacatc      600

tggagtgatg gcggaacgga ttacactgct tccgtaaagg ggcgatttac catttccagg      660

gacggtagca aaagtatcgc gtaccttcaa atgaactccc tcaagacaga ggatacggct      720

gtgtactact gcgcgaggga aggatattgg ctcggggcat tcgacccatg gggtcaggga      780

acctcagtca ccgtcagc                                                    798


<210>  82
<211>  266
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized_scFv_podo447VL6_GGGGS_VH

<400>  82

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys Ala Ala Gln Leu Thr Gln Ser Pro Ser Pro 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Val His His Lys Asn Asp Leu Ala Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Thr Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Ala Gly Val Tyr Glu Gly Ser Ser Asp Asn Arg Ala Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe 
                165                 170                 175     


Ser Leu Ser Gly Tyr Gln Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Gly Tyr Ile Trp Ser Asp Gly Gly Thr Asp Tyr 
        195                 200                 205             


Thr Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Ser Lys 
    210                 215                 220                 


Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Arg Glu Gly Tyr Trp Leu Gly Ala Phe Asp Pro 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265     


<210>  83
<211>  1608
<212>  DNA
<213>  Artificial sequence

<220>
<223>  humanized_scFv_podo447VL6_GGGGS_VH_CAR

<400>  83
atggacatgc gggttccagc gcagctcttg ggactcttgc tgttgtggtt gcccggtgcc       60

aggtgtgcgg cccagcttac acagagtccc tctcctttgt cagcttcagt tggtgatagg      120

gtgactataa cctgtcagag tagtcagtcc gttcaccaca agaacgacct cgcgtggtat      180

cagcagaagc ctggcaaagc gccgaaactg ctcatttact atacgtctac gttggcaagt      240

ggtgtcccct cacggttctc aggctccggt agcgggacag attttactct cacaatcagc      300

tcccttcagc ccgaagattt cgctacatat tattgtgctg gggtatatga ggggagttct      360

gataatcggg catttggggg cggcacgaag gtggagatta aagggggagg tgggtccggc      420

gggggcggca gtggaggcgg cgggtctgaa gtacagcttg tagaatctgg ggggggtctc      480

gttcaaccgg gtaggagttt gagactgagc tgcacggcct ctggcttcag cttgtctgga      540

taccaaatga actgggtgcg acaagcgccc ggcaagggtt tggaatgggt gggttacatc      600

tggagtgatg gcggaacgga ttacactgct tccgtaaagg ggcgatttac catttccagg      660

gacggtagca aaagtatcgc gtaccttcaa atgaactccc tcaagacaga ggatacggct      720

gtgtactact gcgcgaggga aggatattgg ctcggggcat tcgacccatg gggtcaggga      780

acctcagtca ccgtcagcga gcagaagctg atcagcgagg aggacctgaa ccggatccgt      840

ggggtcaccg tctcttcagc gctgagcaac tccatcatgt acttcagcca cttcgtgccg      900

gtcttcctgc cagcgaagcc caccacgacg ccagcgccgc gaccaccaac accggcgccc      960

accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc     1020

gcagtgcaca cgagggggct ggaccccttt gggttttggg tgctggtggt ggttggtgga     1080

gtcctggctt gctatagctt gctagtaaca gtggccttta ttattttctg ggtgaggagt     1140

aagaggagca ggctcctgca cagtgactac atgaacatga ctccccgccg ccccgggccc     1200

acccgcaagc attaccagcc ctatgcccca ccacgcgact tcgcagccta tcgctccctc     1260

gagagagtga gagtgaagtt cagcaggagc gcagacgccc ccgcgtacca gcagggccag     1320

aaccagctct ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag     1380

agacgtggcc gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc     1440

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     1500

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc     1560

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgctaa                  1608


<210>  84
<211>  535
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized_scFv_podo447VL6_GGGGS_VH_CAR

<400>  84

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys Ala Ala Gln Leu Thr Gln Ser Pro Ser Pro 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Val His His Lys Asn Asp Leu Ala Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Thr Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Ala Gly Val Tyr Glu Gly Ser Ser Asp Asn Arg Ala Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe 
                165                 170                 175     


Ser Leu Ser Gly Tyr Gln Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Gly Tyr Ile Trp Ser Asp Gly Gly Thr Asp Tyr 
        195                 200                 205             


Thr Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Ser Lys 
    210                 215                 220                 


Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Arg Glu Gly Tyr Trp Leu Gly Ala Phe Asp Pro 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Glu Gln Lys Leu Ile Ser 
            260                 265                 270         


Glu Glu Asp Leu Asn Arg Ile Arg Gly Val Thr Val Ser Ser Ala Leu 
        275                 280                 285             


Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu Pro 
    290                 295                 300                 


Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
305                 310                 315                 320 


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
                325                 330                 335     


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Pro Phe Gly Phe 
            340                 345                 350         


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
        355                 360                 365             


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
    370                 375                 380                 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
385                 390                 395                 400 


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
                405                 410                 415     


Tyr Arg Ser Leu Glu Arg Val Arg Val Lys Phe Ser Arg Ser Ala Asp 
            420                 425                 430         


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
        435                 440                 445             


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
    450                 455                 460                 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
465                 470                 475                 480 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                485                 490                 495     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            500                 505                 510         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        515                 520                 525             


Met Gln Ala Leu Pro Pro Arg 
    530                 535 


