                         SEQUENCE LISTING

<110>  Heat Biologics, Inc.
      
 
<120>  COMPOSITIONS AND METHODS FOR ADJOINING TYPE I AND TYPE II  
       EXTRACELLULAR DOMAINS AS HETEROLOGOUS CHIMERIC PROTEINS

<130>  HTB-023PC

<150>  US 62/235,727
<151>  2015-10-01

<150>  US 62/263,313
<151>  2015-12-04

<150>  US 62/372,574
<151>  2016-08-09

<160>  78    

<170>  PatentIn version 3.5

<210>  1
<211>  1605
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  1
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca atctaagtac ggccctccct gccctagctg tcccgcccct      540

gaatttctgg gcggaccctc cgtgtttctg ttccccccaa agcccaagga caccctgatg      600

atcagccgga cccccgaagt gacctgtgtg gtggtggatg tgtcccagga agatcccgag      660

gtgcagttca attggtacgt ggacggggtg gaagtgcaca acgccaagac caagcccaga      720

gaggaacagt tcaacagcac ctaccgggtg gtgtctgtgc tgaccgtgct gcaccaggat      780

tggctgagcg gcaaagagta caagtgcaag gtgtccagca agggcctgcc cagcagcatc      840

gaaaagacca tcagcaacgc caccggccag cccagggaac cccaggtgta cacactgccc      900

cctagccagg aagagatgac caagaaccag gtgtccctga catgcctcgt gaagggcttc      960

tacccctccg atatcgccgt ggaatgggag agcaacggcc agccagagaa caactacaag     1020

accacccccc cagtgctgga cagcgacggc tcattcttcc tgtactcccg gctgacagtg     1080

gacaagagca gctggcagga aggcaacgtg ttcagctgca gcgtgatgca cgaagccctg     1140

cacaaccact acacccagaa gtccctgagc ctgtccctgg gcaaaataga gggacgaatg     1200

gaccaggtat cacatcggta tcctcgaatt caaagtatca aagtacaatt taccgaatat     1260

aagaaggaga aaggtttcat cctcacttcc caaaaggagg atgaaatcat gaaggtgcag     1320

aacaactcag tcatcatcaa ctgtgatggg ttttatctca tctccctgaa gggctacttc     1380

tcccaggaag tcaacattag ccttcattac cagaaggatg aggagcccct cttccaactg     1440

aagaaggtca ggtctgtcaa ctccttgatg gtggcctctc tgacttacaa agacaaagtc     1500

tacttgaatg tgaccactga caatacctcc ctggatgact tccatgtgaa tggcggagaa     1560

ctgattctta tccatcaaaa tcctggtgaa ttctgtgtcc tttga                     1605


<210>  2
<211>  534
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  2

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Ser Lys Tyr Gly Pro Pro Cys Pro Ser 
                165                 170                 175     


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            180                 185                 190         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        195                 200                 205             


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
    210                 215                 220                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
225                 230                 235                 240 


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                245                 250                 255     


Leu His Gln Asp Trp Leu Ser Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            260                 265                 270         


Ser Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Asn Ala Thr 
        275                 280                 285             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
    290                 295                 300                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
305                 310                 315                 320 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                325                 330                 335     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            340                 345                 350         


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Ser Trp Gln Glu Gly 
        355                 360                 365             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    370                 375                 380                 


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ile Glu Gly Arg Met 
385                 390                 395                 400 


Asp Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln 
                405                 410                 415     


Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys 
            420                 425                 430         


Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys 
        435                 440                 445             


Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val 
    450                 455                 460                 


Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu 
465                 470                 475                 480 


Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr 
                485                 490                 495     


Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp 
            500                 505                 510         


Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro 
        515                 520                 525             


Gly Glu Phe Cys Val Leu 
    530                 


<210>  3
<211>  1782
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  3
atgcagattc ctcaggcccc ttggcctgtc gtgtgggctg tgctgcagct gggatggcgg       60

cctggctggt ttctggacag ccccgacaga ccctggaacc cccctacatt ttcccctgcc      120

ctgctggtcg tgaccgaggg cgacaatgcc accttcacct gtagcttcag caacaccagc      180

gagagcttcg tgctgaactg gtacagaatg agccccagca accagaccga caagctggcc      240

gccttccccg aggatagatc tcagcccggc caggactgcc ggttcagagt gacccagctg      300

cccaacggcc gggacttcca catgtctgtc gtgcgggcca gacggaacga cagcggcaca      360

tatctgtgcg gcgccatcag cctggccccc aaggcccaga tcaaagagag cctgagagcc      420

gagctgagag tgaccgagag aagggccgaa gtgcctaccg cccaccctag cccatctcca      480

agacctgccg gccagttcca gtctaagtac ggccctcctt gccccagctg tcccgcccct      540

gaatttctgg gcggacccag cgtgttcctg ttccccccaa agcccaagga caccctgatg      600

atcagccgga cccccgaagt gacctgcgtg gtggtggatg tgtcccagga agatcccgag      660

gtgcagttca attggtacgt ggacggcgtg gaagtgcaca acgccaagac caagcccaga      720

gaggaacagt tcaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggat      780

tggctgagcg gcaaagagta caagtgcaag gtgtccagca agggcctgcc cagcagcatc      840

gagaaaacca tcagcaacgc caccggccag cccagggaac cccaggtgta cacactgccc      900

cctagccagg aagagatgac caagaaccag gtgtccctga cctgtctcgt gaagggcttc      960

tacccctccg atatcgccgt ggaatgggag agcaacggcc agcctgagaa caactacaag     1020

accacccccc cagtgctgga cagcgacggc tcatttttcc tgtactccag actgaccgtg     1080

gacaagagca gctggcagga aggcaacgtg ttcagctgct ccgtgatgca cgaggccctg     1140

cacaaccact acacccagaa gtccctgtct ctgagcctgg gcaagatcga gggccggatg     1200

gatagagccc agggcgaagc ctgcgtgcag ttccaggctc tgaagggcca ggaattcgcc     1260

cccagccacc agcaggtgta cgcccctctg agagctgacg gcgacaagcc tagagcccac     1320

ctgacagtcg tgcggcagac ccctacccag cacttcaaga atcagttccc agccctgcac     1380

tgggagcacg agctgggcct ggccttcacc aagaacagaa tgaactacac caacaagttt     1440

ctgctgatcc ccgagagcgg cgactacttc atctacagcc aagtgacctt ccggggcatg     1500

accagcgagt gcagcgagat cagacaggcc ggcagaccta acaagcccga cagcatcacc     1560

gtcgtgatca ccaaagtgac cgacagctac cccgagccca cacagctgct gatgggcacc     1620

aagagcgtgt gcgaagtggg cagcaactgg ttccagccca tctacctggg cgccatgttc     1680

agtctgcaag agggcgataa gctgatggtc aacgtgtccg acatctccct ggtggattac     1740

accaaagagg acaagacctt cttcggcgcc tttctgctct ga                        1782


<210>  4
<211>  1782
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  4
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca atctaagtac ggccctccct gccctagctg tcccgcccct      540

gaatttctgg gcggaccctc cgtgtttctg ttccccccaa agcccaagga caccctgatg      600

atcagccgga cccccgaagt gacctgtgtg gtggtggatg tgtcccagga agatcccgag      660

gtgcagttca attggtacgt ggacggggtg gaagtgcaca acgccaagac caagcccaga      720

gaggaacagt tcaacagcac ctaccgggtg gtgtctgtgc tgaccgtgct gcaccaggat      780

tggctgagcg gcaaagagta caagtgcaag gtgtccagca agggcctgcc cagcagcatc      840

gaaaagacca tcagcaacgc caccggccag cccagggaac cccaggtgta cacactgccc      900

cctagccagg aagagatgac caagaaccag gtgtccctga catgcctcgt gaagggcttc      960

tacccctccg atatcgccgt ggaatgggag agcaacggcc agccagagaa caactacaag     1020

accacccccc cagtgctgga cagcgacggc tcattcttcc tgtactcccg gctgacagtg     1080

gacaagagca gctggcagga aggcaacgtg ttcagctgca gcgtgatgca cgaagccctg     1140

cacaaccact acacccagaa gtccctgagc ctgtccctgg gcaaaataga gggacgaatg     1200

gaccgggccc agggagaggc ctgtgtgcag ttccaggctc taaaaggaca ggagtttgca     1260

ccttcacatc agcaagttta tgcacctctt agagcagacg gagataagcc aagggcacac     1320

ctgacagttg tgagacaaac tcccacacag cactttaaaa atcagttccc agctctgcac     1380

tgggaacatg aactaggcct ggccttcacc aagaaccgaa tgaactatac caacaaattc     1440

ctgctgatcc cagagtcggg agactacttc atttactccc aggtcacatt ccgtgggatg     1500

acctctgagt gcagtgaaat cagacaagca ggccgaccaa acaagccaga ctccatcact     1560

gtggtcatca ccaaggtaac agacagctac cctgagccaa cccagctcct catggggacc     1620

aagtctgtat gcgaagtagg tagcaactgg ttccagccca tctacctcgg agccatgttc     1680

tccttgcaag aaggggacaa gctaatggtg aacgtcagtg acatctcttt ggtggattac     1740

acaaaagaag ataaaacctt ctttggagcc ttcttactat ag                        1782


<210>  5
<211>  593
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  5

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Ser Lys Tyr Gly Pro Pro Cys Pro Ser 
                165                 170                 175     


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            180                 185                 190         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        195                 200                 205             


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
    210                 215                 220                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
225                 230                 235                 240 


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                245                 250                 255     


Leu His Gln Asp Trp Leu Ser Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            260                 265                 270         


Ser Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Asn Ala Thr 
        275                 280                 285             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
    290                 295                 300                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
305                 310                 315                 320 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                325                 330                 335     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            340                 345                 350         


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Ser Trp Gln Glu Gly 
        355                 360                 365             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    370                 375                 380                 


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ile Glu Gly Arg Met 
385                 390                 395                 400 


Asp Arg Ala Gln Gly Glu Ala Cys Val Gln Phe Gln Ala Leu Lys Gly 
                405                 410                 415     


Gln Glu Phe Ala Pro Ser His Gln Gln Val Tyr Ala Pro Leu Arg Ala 
            420                 425                 430         


Asp Gly Asp Lys Pro Arg Ala His Leu Thr Val Val Arg Gln Thr Pro 
        435                 440                 445             


Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His Trp Glu His Glu 
    450                 455                 460                 


Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe 
465                 470                 475                 480 


Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr 
                485                 490                 495     


Phe Arg Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg 
            500                 505                 510         


Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys Val Thr Asp 
        515                 520                 525             


Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys Ser Val Cys 
    530                 535                 540                 


Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe 
545                 550                 555                 560 


Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser Asp Ile Ser 
                565                 570                 575     


Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu 
            580                 585                 590         


Leu 
    


<210>  6
<211>  1554
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  6
atgaagacat tgcctgccat gcttggaact gggaaattat tttgggtctt cttcttaatc       60

ccatatctgg acatctggaa catccatggg aaagaatcat gtgatgtaca gctttatata      120

aagagacaat ctgaacactc catcttagca ggagatccct ttgaactaga atgccctgtg      180

aaatactgtg ctaacaggcc tcatgtgact tggtgcaagc tcaatggaac aacatgtgta      240

aaacttgaag atagacaaac aagttggaag gaagagaaga acatttcatt tttcattcta      300

cattttgaac cagtgcttcc taatgacaat gggtcatacc gctgttctgc aaattttcag      360

tctaatctca ttgaaagcca ctcaacaact ctttatgtga cagatgtaaa aagtgcctca      420

gaacgaccct ccaaggacga aatggcaagc tctaagtacg gccctccctg ccctagctgt      480

cccgcccctg aatttctggg cggaccctcc gtgtttctgt tccccccaaa gcccaaggac      540

accctgatga tcagccggac ccccgaagtg acctgtgtgg tggtggatgt gtcccaggaa      600

gatcccgagg tgcagttcaa ttggtacgtg gacggggtgg aagtgcacaa cgccaagacc      660

aagcccagag aggaacagtt caacagcacc taccgggtgg tgtctgtgct gaccgtgctg      720

caccaggatt ggctgagcgg caaagagtac aagtgcaagg tgtccagcaa gggcctgccc      780

agcagcatcg aaaagaccat cagcaacgcc accggccagc ccagggaacc ccaggtgtac      840

acactgcccc ctagccagga agagatgacc aagaaccagg tgtccctgac atgcctcgtg      900

aagggcttct acccctccga tatcgccgtg gaatgggaga gcaacggcca gccagagaac      960

aactacaaga ccaccccccc agtgctggac agcgacggct cattcttcct gtactcccgg     1020

ctgacagtgg acaagagcag ctggcaggaa ggcaacgtgt tcagctgcag cgtgatgcac     1080

gaagccctgc acaaccacta cacccagaag tccctgagcc tgtccctggg caaaatagag     1140

ggacgaatgg accaggtatc acatcggtat cctcgaattc aaagtatcaa agtacaattt     1200

accgaatata agaaggagaa aggtttcatc ctcacttccc aaaaggagga tgaaatcatg     1260

aaggtgcaga acaactcagt catcatcaac tgtgatgggt tttatctcat ctccctgaag     1320

ggctacttct cccaggaagt caacattagc cttcattacc agaaggatga ggagcccctc     1380

ttccaactga agaaggtcag gtctgtcaac tccttgatgg tggcctctct gacttacaaa     1440

gacaaagtct acttgaatgt gaccactgac aatacctccc tggatgactt ccatgtgaat     1500

ggcggagaac tgattcttat ccatcaaaat cctggtgaat tctgtgtcct ttga           1554


<210>  7
<211>  517
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  7

Met Lys Thr Leu Pro Ala Met Leu Gly Thr Gly Lys Leu Phe Trp Val 
1               5                   10                  15      


Phe Phe Leu Ile Pro Tyr Leu Asp Ile Trp Asn Ile His Gly Lys Glu 
            20                  25                  30          


Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His Ser Ile 
        35                  40                  45              


Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr Cys Ala 
    50                  55                  60                  


Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr Cys Val 
65                  70                  75                  80  


Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn Ile Ser 
                85                  90                  95      


Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn Gly Ser 
            100                 105                 110         


Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser His Ser 
        115                 120                 125             


Thr Thr Leu Tyr Val Thr Asp Val Lys Ser Ala Ser Glu Arg Pro Ser 
    130                 135                 140                 


Lys Asp Glu Met Ala Ser Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys 
145                 150                 155                 160 


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                165                 170                 175     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            180                 185                 190         


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
        195                 200                 205             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    210                 215                 220                 


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
225                 230                 235                 240 


His Gln Asp Trp Leu Ser Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser 
                245                 250                 255     


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Asn Ala Thr Gly 
            260                 265                 270         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
        275                 280                 285             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    290                 295                 300                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
305                 310                 315                 320 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                325                 330                 335     


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Ser Trp Gln Glu Gly Asn 
            340                 345                 350         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        355                 360                 365             


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ile Glu Gly Arg Met Asp 
    370                 375                 380                 


Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe 
385                 390                 395                 400 


Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu 
                405                 410                 415     


Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp 
            420                 425                 430         


Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn 
        435                 440                 445             


Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys 
    450                 455                 460                 


Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys 
465                 470                 475                 480 


Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
                485                 490                 495     


Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly 
            500                 505                 510         


Glu Phe Cys Val Leu 
        515         


<210>  8
<211>  1527
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  8
atgcgctggt gtctcctcct gatctgggcc caggggctga ggcaggctcc cctcgcctca       60

ggaatgatga caggcacaat agaaacaacg gggaacattt ctgcagagaa aggtggctct      120

atcatcttac aatgtcacct ctcctccacc acggcacaag tgacccaggt caactgggag      180

cagcaggacc agcttctggc catttgtaat gctgacttgg ggtggcacat ctccccatcc      240

ttcaaggatc gagtggcccc aggtcccggc ctgggcctca ccctccagtc gctgaccgtg      300

aacgatacag gggagtactt ctgcatctat cacacctacc ctgatgggac gtacactggg      360

agaatcttcc tggaggtcct agaaagctca gtggctgagc acggtgccag gttccagatt      420

ccatctaagt acggccctcc ctgccctagc tgtcccgccc ctgaatttct gggcggaccc      480

tccgtgtttc tgttcccccc aaagcccaag gacaccctga tgatcagccg gacccccgaa      540

gtgacctgtg tggtggtgga tgtgtcccag gaagatcccg aggtgcagtt caattggtac      600

gtggacgggg tggaagtgca caacgccaag accaagccca gagaggaaca gttcaacagc      660

acctaccggg tggtgtctgt gctgaccgtg ctgcaccagg attggctgag cggcaaagag      720

tacaagtgca aggtgtccag caagggcctg cccagcagca tcgaaaagac catcagcaac      780

gccaccggcc agcccaggga accccaggtg tacacactgc cccctagcca ggaagagatg      840

accaagaacc aggtgtccct gacatgcctc gtgaagggct tctacccctc cgatatcgcc      900

gtggaatggg agagcaacgg ccagccagag aacaactaca agaccacccc cccagtgctg      960

gacagcgacg gctcattctt cctgtactcc cggctgacag tggacaagag cagctggcag     1020

gaaggcaacg tgttcagctg cagcgtgatg cacgaagccc tgcacaacca ctacacccag     1080

aagtccctga gcctgtccct gggcaaaata gagggacgaa tggaccaggt atcacatcgg     1140

tatcctcgaa ttcaaagtat caaagtacaa tttaccgaat ataagaagga gaaaggtttc     1200

atcctcactt cccaaaagga ggatgaaatc atgaaggtgc agaacaactc agtcatcatc     1260

aactgtgatg ggttttatct catctccctg aagggctact tctcccagga agtcaacatt     1320

agccttcatt accagaagga tgaggagccc ctcttccaac tgaagaaggt caggtctgtc     1380

aactccttga tggtggcctc tctgacttac aaagacaaag tctacttgaa tgtgaccact     1440

gacaatacct ccctggatga cttccatgtg aatggcggag aactgattct tatccatcaa     1500

aatcctggtg aattctgtgt cctttga                                         1527


<210>  9
<211>  508
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  9

Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala 
1               5                   10                  15      


Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn 
            20                  25                  30          


Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser 
        35                  40                  45              


Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln 
    50                  55                  60                  


Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser 
65                  70                  75                  80  


Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln 
                85                  90                  95      


Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr 
            100                 105                 110         


Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu 
        115                 120                 125             


Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Ser Lys Tyr 
    130                 135                 140                 


Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
145                 150                 155                 160 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                165                 170                 175     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            180                 185                 190         


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        195                 200                 205             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    210                 215                 220                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Ser Gly Lys Glu 
225                 230                 235                 240 


Tyr Lys Cys Lys Val Ser Ser Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                245                 250                 255     


Thr Ile Ser Asn Ala Thr Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            260                 265                 270         


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        275                 280                 285             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    290                 295                 300                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
305                 310                 315                 320 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
                325                 330                 335     


Ser Ser Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            340                 345                 350         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        355                 360                 365             


Lys Ile Glu Gly Arg Met Asp Gln Val Ser His Arg Tyr Pro Arg Ile 
    370                 375                 380                 


Gln Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe 
385                 390                 395                 400 


Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn 
                405                 410                 415     


Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly 
            420                 425                 430         


Tyr Phe Ser Gln Glu Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu 
        435                 440                 445             


Glu Pro Leu Phe Gln Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met 
    450                 455                 460                 


Val Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr 
465                 470                 475                 480 


Asp Asn Thr Ser Leu Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile 
                485                 490                 495     


Leu Ile His Gln Asn Pro Gly Glu Phe Cys Val Leu 
            500                 505             


<210>  10
<211>  1710
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  10
atgttttcac atcttccctt tgactgtgtc ctgctgctgc tgctgctact acttacaagg       60

tcctcagaag tggaatacag agcggaggtc ggtcagaatg cctatctgcc ctgcttctac      120

accccagccg ccccagggaa cctcgtgccc gtctgctggg gcaaaggagc ctgtcctgtg      180

tttgaatgtg gcaacgtggt gctcaggact gatgaaaggg atgtgaatta ttggacatcc      240

agatactggc taaatgggga tttccgcaaa ggagatgtgt ccctgaccat agagaatgtg      300

actctagcag acagtgggat ctactgctgc cggatccaaa tcccaggcat aatgaatgat      360

gaaaaattta acctgaagtt ggtcatcaaa ccagccaagg tcacccctgc accgactcgg      420

cagagagact tcactgcagc ctttccaagg atgcttacca ccaggggaca tggcccagca      480

gagacacaga cactggggag cctccctgat ataaatctaa cacaaatatc cacattggcc      540

aatgagttac gggactctag attggccaat gacttacggg actctggagc aaccatcaga      600

ataggctcta agtacggccc tccctgccct agctgtcccg cccctgaatt tctgggcgga      660

ccctccgtgt ttctgttccc cccaaagccc aaggacaccc tgatgatcag ccggaccccc      720

gaagtgacct gtgtggtggt ggatgtgtcc caggaagatc ccgaggtgca gttcaattgg      780

tacgtggacg gggtggaagt gcacaacgcc aagaccaagc ccagagagga acagttcaac      840

agcacctacc gggtggtgtc tgtgctgacc gtgctgcacc aggattggct gagcggcaaa      900

gagtacaagt gcaaggtgtc cagcaagggc ctgcccagca gcatcgaaaa gaccatcagc      960

aacgccaccg gccagcccag ggaaccccag gtgtacacac tgccccctag ccaggaagag     1020

atgaccaaga accaggtgtc cctgacatgc ctcgtgaagg gcttctaccc ctccgatatc     1080

gccgtggaat gggagagcaa cggccagcca gagaacaact acaagaccac ccccccagtg     1140

ctggacagcg acggctcatt cttcctgtac tcccggctga cagtggacaa gagcagctgg     1200

caggaaggca acgtgttcag ctgcagcgtg atgcacgaag ccctgcacaa ccactacacc     1260

cagaagtccc tgagcctgtc cctgggcaaa atagagggac gaatggacca ggtatcacat     1320

cggtatcctc gaattcaaag tatcaaagta caatttaccg aatataagaa ggagaaaggt     1380

ttcatcctca cttcccaaaa ggaggatgaa atcatgaagg tgcagaacaa ctcagtcatc     1440

atcaactgtg atgggtttta tctcatctcc ctgaagggct acttctccca ggaagtcaac     1500

attagccttc attaccagaa ggatgaggag cccctcttcc aactgaagaa ggtcaggtct     1560

gtcaactcct tgatggtggc ctctctgact tacaaagaca aagtctactt gaatgtgacc     1620

actgacaata cctccctgga tgacttccat gtgaatggcg gagaactgat tcttatccat     1680

caaaatcctg gtgaattctg tgtcctttga                                      1710


<210>  11
<211>  569
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  11

Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly Ser Lys Tyr Gly Pro Pro 
        195                 200                 205             


Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
    210                 215                 220                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
225                 230                 235                 240 


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
                245                 250                 255     


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            260                 265                 270         


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
        275                 280                 285             


Leu Thr Val Leu His Gln Asp Trp Leu Ser Gly Lys Glu Tyr Lys Cys 
    290                 295                 300                 


Lys Val Ser Ser Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
305                 310                 315                 320 


Asn Ala Thr Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                325                 330                 335     


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            340                 345                 350         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        355                 360                 365             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    370                 375                 380                 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Ser Trp 
385                 390                 395                 400 


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                405                 410                 415     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ile Glu 
            420                 425                 430         


Gly Arg Met Asp Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile 
        435                 440                 445             


Lys Val Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr 
    450                 455                 460                 


Ser Gln Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile 
465                 470                 475                 480 


Ile Asn Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser 
                485                 490                 495     


Gln Glu Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu 
            500                 505                 510         


Phe Gln Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser 
        515                 520                 525             


Leu Thr Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr 
    530                 535                 540                 


Ser Leu Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His 
545                 550                 555                 560 


Gln Asn Pro Gly Glu Phe Cys Val Leu 
                565                 


<210>  12
<211>  2223
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  12
atggagcccg ccggcccggc ccccggccgc ctcgggccgc tgctctgcct gctgctcgcc       60

gcgtcctgcg cctggtcagg agtggcgggt gaggaggagc tgcaggtgat tcagcctgac      120

aagtccgtgt tggttgcagc tggagagaca gccactctgc gctgcactgc gacctctctg      180

atccctgtgg ggcccatcca gtggttcaga ggagctggac caggccggga attaatctac      240

aatcaaaaag aaggccactt cccccgggta acaactgttt cagacctcac aaagagaaac      300

aacatggact tttccatccg catcggtaac atcaccccag cagatgccgg cacctactac      360

tgtgtgaagt tccggaaagg gagccccgat gacgtggagt ttaagtctgg agcaggcact      420

gagctgtctg tgcgcgccaa accctctgcc cccgtggtat cgggccctgc ggcgagggcc      480

acacctcagc acacagtgag cttcacctgc gagtcccacg gcttctcacc cagagacatc      540

accctgaaat ggttcaaaaa tgggaatgag ctctcagact tccagaccaa cgtggacccc      600

gtaggagaga gcgtgtccta cagcatccac agcacagcca aggtggtgct gacccgcgag      660

gacgttcact ctcaagtcat ctgcgaggtg gcccacgtca ccttgcaggg ggaccctctt      720

cgtgggactg ccaacttgtc tgagaccatc cgagttccac ccaccttgga ggttactcaa      780

cagcccgtga gggcagagaa ccaggtgaat gtcacctgcc aggtgaggaa gttctacccc      840

cagagactac agctgacctg gttggagaat ggaaacgtgt cccggacaga aacggcctca      900

accgttacag agaacaagga tggtacctac aactggatga gctggctcct ggtgaatgta      960

tctgcccaca gggatgatgt gaagctcacc tgccaggtgg agcatgacgg gcagccagcg     1020

gtcagcaaaa gccatgacct gaaggtctca gcccacccga aggagcaggg ctcaaatacc     1080

gccgctgaga acactggatc taatgaacgg aacatctatt ctaagtacgg ccctccctgc     1140

cctagctgtc ccgcccctga atttctgggc ggaccctccg tgtttctgtt ccccccaaag     1200

cccaaggaca ccctgatgat cagccggacc cccgaagtga cctgtgtggt ggtggatgtg     1260

tcccaggaag atcccgaggt gcagttcaat tggtacgtgg acggggtgga agtgcacaac     1320

gccaagacca agcccagaga ggaacagttc aacagcacct accgggtggt gtctgtgctg     1380

accgtgctgc accaggattg gctgagcggc aaagagtaca agtgcaaggt gtccagcaag     1440

ggcctgccca gcagcatcga aaagaccatc agcaacgcca ccggccagcc cagggaaccc     1500

caggtgtaca cactgccccc tagccaggaa gagatgacca agaaccaggt gtccctgaca     1560

tgcctcgtga agggcttcta cccctccgat atcgccgtgg aatgggagag caacggccag     1620

ccagagaaca actacaagac caccccccca gtgctggaca gcgacggctc attcttcctg     1680

tactcccggc tgacagtgga caagagcagc tggcaggaag gcaacgtgtt cagctgcagc     1740

gtgatgcacg aagccctgca caaccactac acccagaagt ccctgagcct gtccctgggc     1800

aaaatagagg gacgaatgga ccaggtatca catcggtatc ctcgaattca aagtatcaaa     1860

gtacaattta ccgaatataa gaaggagaaa ggtttcatcc tcacttccca aaaggaggat     1920

gaaatcatga aggtgcagaa caactcagtc atcatcaact gtgatgggtt ttatctcatc     1980

tccctgaagg gctacttctc ccaggaagtc aacattagcc ttcattacca gaaggatgag     2040

gagcccctct tccaactgaa gaaggtcagg tctgtcaact ccttgatggt ggcctctctg     2100

acttacaaag acaaagtcta cttgaatgtg accactgaca atacctccct ggatgacttc     2160

catgtgaatg gcggagaact gattcttatc catcaaaatc ctggtgaatt ctgtgtcctt     2220

tga                                                                   2223


<210>  13
<211>  740
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  13

Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 
            20                  25                  30          


Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala Ala Gly 
        35                  40                  45              


Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val Gly 
    50                  55                  60                  


Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr 
65                  70                  75                  80  


Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu 
                85                  90                  95      


Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn Ile Thr 
            100                 105                 110         


Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 
        115                 120                 125             


Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val 
    130                 135                 140                 


Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala 
145                 150                 155                 160 


Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 
                165                 170                 175     


Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser 
            180                 185                 190         


Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser 
        195                 200                 205             


Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser 
    210                 215                 220                 


Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu 
225                 230                 235                 240 


Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu 
                245                 250                 255     


Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 
            260                 265                 270         


Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 
        275                 280                 285             


Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 
    290                 295                 300                 


Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 
305                 310                 315                 320 


Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 
                325                 330                 335     


Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His 
            340                 345                 350         


Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn 
        355                 360                 365             


Glu Arg Asn Ile Tyr Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
    370                 375                 380                 


Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
385                 390                 395                 400 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                405                 410                 415     


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            420                 425                 430         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        435                 440                 445             


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    450                 455                 460                 


Gln Asp Trp Leu Ser Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys 
465                 470                 475                 480 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Asn Ala Thr Gly Gln 
                485                 490                 495     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
            500                 505                 510         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        515                 520                 525             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    530                 535                 540                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
545                 550                 555                 560 


Tyr Ser Arg Leu Thr Val Asp Lys Ser Ser Trp Gln Glu Gly Asn Val 
                565                 570                 575     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            580                 585                 590         


Lys Ser Leu Ser Leu Ser Leu Gly Lys Ile Glu Gly Arg Met Asp Gln 
        595                 600                 605             


Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr 
    610                 615                 620                 


Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp 
625                 630                 635                 640 


Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly 
                645                 650                 655     


Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile 
            660                 665                 670         


Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys 
        675                 680                 685             


Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp 
    690                 695                 700                 


Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe 
705                 710                 715                 720 


His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu 
                725                 730                 735     


Phe Cys Val Leu 
            740 


<210>  14
<211>  1554
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  14
atggggtccc cgggcatggt gctgggcctc ctggtgcaga tctgggccct gcaagaagcc       60

tcaagcctga gcgtgcagca ggggcccaac ttgctgcagg tgaggcaggg cagtcaggcg      120

accctggtct gccaggtgga ccaggccaca gcctgggaac ggctccgtgt taagtggaca      180

aaggatgggg ccatcctgtg tcaaccgtac atcaccaacg gcagcctcag cctgggggtc      240

tgcgggcccc agggacggct ctcctggcag gcacccagcc atctcaccct gcagctggac      300

cctgtgagcc tcaaccacag cggggcgtac gtgtgctggg cggccgtaga gattcctgag      360

ttggaggagg ctgagggcaa cataacaagg ctctttgtgg acccagatga ccccacacag      420

aacagaaacc ggatcgcaag cttcccagga tctaagtacg gccctccctg ccctagctgt      480

cccgcccctg aatttctggg cggaccctcc gtgtttctgt tccccccaaa gcccaaggac      540

accctgatga tcagccggac ccccgaagtg acctgtgtgg tggtggatgt gtcccaggaa      600

gatcccgagg tgcagttcaa ttggtacgtg gacggggtgg aagtgcacaa cgccaagacc      660

aagcccagag aggaacagtt caacagcacc taccgggtgg tgtctgtgct gaccgtgctg      720

caccaggatt ggctgagcgg caaagagtac aagtgcaagg tgtccagcaa gggcctgccc      780

agcagcatcg aaaagaccat cagcaacgcc accggccagc ccagggaacc ccaggtgtac      840

acactgcccc ctagccagga agagatgacc aagaaccagg tgtccctgac atgcctcgtg      900

aagggcttct acccctccga tatcgccgtg gaatgggaga gcaacggcca gccagagaac      960

aactacaaga ccaccccccc agtgctggac agcgacggct cattcttcct gtactcccgg     1020

ctgacagtgg acaagagcag ctggcaggaa ggcaacgtgt tcagctgcag cgtgatgcac     1080

gaagccctgc acaaccacta cacccagaag tccctgagcc tgtccctggg caaaatagag     1140

ggacgaatgg accaggtatc acatcggtat cctcgaattc aaagtatcaa agtacaattt     1200

accgaatata agaaggagaa aggtttcatc ctcacttccc aaaaggagga tgaaatcatg     1260

aaggtgcaga acaactcagt catcatcaac tgtgatgggt tttatctcat ctccctgaag     1320

ggctacttct cccaggaagt caacattagc cttcattacc agaaggatga ggagcccctc     1380

ttccaactga agaaggtcag gtctgtcaac tccttgatgg tggcctctct gacttacaaa     1440

gacaaagtct acttgaatgt gaccactgac aatacctccc tggatgactt ccatgtgaat     1500

ggcggagaac tgattcttat ccatcaaaat cctggtgaat tctgtgtcct ttga           1554


<210>  15
<211>  517
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  15

Met Gly Ser Pro Gly Met Val Leu Gly Leu Leu Val Gln Ile Trp Ala 
1               5                   10                  15      


Leu Gln Glu Ala Ser Ser Leu Ser Val Gln Gln Gly Pro Asn Leu Leu 
            20                  25                  30          


Gln Val Arg Gln Gly Ser Gln Ala Thr Leu Val Cys Gln Val Asp Gln 
        35                  40                  45              


Ala Thr Ala Trp Glu Arg Leu Arg Val Lys Trp Thr Lys Asp Gly Ala 
    50                  55                  60                  


Ile Leu Cys Gln Pro Tyr Ile Thr Asn Gly Ser Leu Ser Leu Gly Val 
65                  70                  75                  80  


Cys Gly Pro Gln Gly Arg Leu Ser Trp Gln Ala Pro Ser His Leu Thr 
                85                  90                  95      


Leu Gln Leu Asp Pro Val Ser Leu Asn His Ser Gly Ala Tyr Val Cys 
            100                 105                 110         


Trp Ala Ala Val Glu Ile Pro Glu Leu Glu Glu Ala Glu Gly Asn Ile 
        115                 120                 125             


Thr Arg Leu Phe Val Asp Pro Asp Asp Pro Thr Gln Asn Arg Asn Arg 
    130                 135                 140                 


Ile Ala Ser Phe Pro Gly Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys 
145                 150                 155                 160 


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                165                 170                 175     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            180                 185                 190         


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
        195                 200                 205             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    210                 215                 220                 


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
225                 230                 235                 240 


His Gln Asp Trp Leu Ser Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser 
                245                 250                 255     


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Asn Ala Thr Gly 
            260                 265                 270         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
        275                 280                 285             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    290                 295                 300                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
305                 310                 315                 320 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                325                 330                 335     


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Ser Trp Gln Glu Gly Asn 
            340                 345                 350         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        355                 360                 365             


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ile Glu Gly Arg Met Asp 
    370                 375                 380                 


Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe 
385                 390                 395                 400 


Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu 
                405                 410                 415     


Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp 
            420                 425                 430         


Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn 
        435                 440                 445             


Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys 
    450                 455                 460                 


Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys 
465                 470                 475                 480 


Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
                485                 490                 495     


Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly 
            500                 505                 510         


Glu Phe Cys Val Leu 
        515         


<210>  16
<211>  3493
<212>  DNA
<213>  Homo sapiens

<400>  16
tcaatcgcct tttatctctg gccctgggac ctttgcctat tttctgattg ataggctttg       60

ttttgtcttt acctccttct ttctggggaa aacttcagtt ttatcgcacg ttcccctttt      120

ccatatcttc atcttccctc tacccagatt gtgaagatgg aaagggtcca acccctggaa      180

gagaatgtgg gaaatgcagc caggccaaga ttcgagagga acaagctatt gctggtggcc      240

tctgtaattc agggactggg gctgctcctg tgcttcacct acatctgcct gcacttctct      300

gctcttcagg tatcacatcg gtatcctcga attcaaagta tcaaagtaca atttaccgaa      360

tataagaagg agaaaggttt catcctcact tcccaaaagg aggatgaaat catgaaggtg      420

cagaacaact cagtcatcat caactgtgat gggttttatc tcatctccct gaagggctac      480

ttctcccagg aagtcaacat tagccttcat taccagaagg atgaggagcc cctcttccaa      540

ctgaagaagg tcaggtctgt caactccttg atggtggcct ctctgactta caaagacaaa      600

gtctacttga atgtgaccac tgacaatacc tccctggatg acttccatgt gaatggcgga      660

gaactgattc ttatccatca aaatcctggt gaattctgtg tcctttgagg ggctgatggc      720

aatatctaaa accaggcacc agcatgaaca ccaagctggg ggtggacagg gcatggattc      780

ttcattgcaa gtgaaggagc ctcccagctc agccacgtgg gatgtgacaa gaagcagatc      840

ctggccctcc cgcccccacc cctcagggat atttaaaact tattttatat accagttaat      900

cttatttatc cttatatttt ctaaattgcc tagccgtcac accccaagat tgccttgagc      960

ctactaggca cctttgtgag aaagaaaaaa tagatgcctc ttcttcaaga tgcattgttt     1020

ctattggtca ggcaattgtc ataataaact tatgtcattg aaaacggtac ctgactacca     1080

tttgctggaa atttgacatg tgtgtggcat tatcaaaatg aagaggagca aggagtgaag     1140

gagtggggtt atgaatctgc caaaggtggt atgaaccaac ccctggaagc caaagcggcc     1200

tctccaaggt taaattgatt gcagtttgca tattgcctaa atttaaactt tctcatttgg     1260

tgggggttca aaagaagaat cagcttgtga aaaatcagga cttgaagaga gccgtctaag     1320

aaataccacg tgcttttttt ctttaccatt ttgctttccc agcctccaaa catagttaat     1380

agaaatttcc cttcaaagaa ctgtctgggg atgtgatgct ttgaaaaatc taatcagtga     1440

cttaagagag attttcttgt atacagggag agtgagataa cttattgtga agggttagct     1500

ttactgtaca ggatagcagg gaactggaca tctcagggta aaagtcagta cggattttaa     1560

tagcctgggg aggaaaacac attctttgcc acagacaggc aaagcaacac atgctcatcc     1620

tcctgcctat gctgagatac gcactcagct ccatgtcttg tacacacaga aacattgctg     1680

gtttcaagaa atgaggtgat cctattatca aattcaatct gatgtcaaat agcactaaga     1740

agttattgtg ccttatgaaa aataatgatc tctgtctaga aataccatag accatatata     1800

gtctcacatt gataattgaa actagaaggg tctataatca gcctatgcca gggcttcaat     1860

ggaatagtat ccccttatgt ttagttgaaa tgtcccctta acttgatata atgtgttatg     1920

cttatggcgc tgtggacaat ctgatttttc atgtcaactt tccagatgat ttgtaacttc     1980

tctgtgccaa accttttata aacataaatt tttgagatat gtattttaaa attgtagcac     2040

atgtttccct gacattttca atagaggata caacatcaca gaatctttct ggatgattct     2100

gtgttatcaa ggaattgtac tgtgctacaa ttatctctag aatctccaga aaggtggagg     2160

gctgttcgcc cttacactaa atggtctcag ttggattttt ttttcctgtt ttctatttcc     2220

tcttaagtac accttcaact atattcccat ccctctattt taatctgtta tgaaggaagg     2280

taaataaaaa tgctaaatag aagaaattgt aggtaaggta agaggaatca agttctgagt     2340

ggctgccaag gcactcacag aatcataatc atggctaaat atttatggag ggcctactgt     2400

ggaccaggca ctgggctaaa tacttacatt tacaagaatc attctgagac agatattcaa     2460

tgatatctgg cttcactact cagaagattg tgtgtgtgtt tgtgtgtgtg tgtgtgtgtg     2520

tatttcactt tttgttattg accatgttct gcaaaattgc agttactcag tgagtgatat     2580

ccgaaaaagt aaacgtttat gactataggt aatatttaag aaaatgcatg gttcattttt     2640

aagtttggaa tttttatcta tatttctcac agatgtgcag tgcacatgca ggcctaagta     2700

tatgttgtgt gtgttgtttg tctttgatgt catggtcccc tctcttaggt gctcactcgc     2760

tttgggtgca cctggcctgc tcttcccatg ttggcctctg caaccacaca gggatatttc     2820

tgctatgcac cagcctcact ccaccttcct tccatcaaaa atatgtgtgt gtgtctcagt     2880

ccctgtaagt catgtccttc acagggagaa ttaacccttc gatatacatg gcagagtttt     2940

gtgggaaaag aattgaatga aaagtcagga gatcagaatt ttaaatttga cttagccact     3000

aactagccat gtaaccttgg gaaagtcatt tcccatttct gggtcttgct tttctttctg     3060

ttaaatgaga ggaatgttaa atatctaaca gtttagaatc ttatgcttac agtgttatct     3120

gtgaatgcac atattaaatg tctatgttct tgttgctatg agtcaaggag tgtaaccttc     3180

tcctttacta tgttgaatgt atttttttct ggacaagctt acatcttcct cagccatctt     3240

tgtgagtcct tcaagagcag ttatcaattg ttagttagat attttctatt tagagaatgc     3300

ttaagggatt ccaatcccga tccaaatcat aatttgttct taagtatact gggcaggtcc     3360

cctattttaa gtcataattt tgtatttagt gctttcctgg ctctcagaga gtattaatat     3420

tgatattaat aatatagtta atagtaatat tgctatttac atggaaacaa ataaaagatc     3480

tcagaattca cta                                                        3493


<210>  17
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly Asn Ala Ala Arg 
1               5                   10                  15      


Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val Ala Ser Val Ile Gln 
            20                  25                  30          


Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser 
        35                  40                  45              


Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val 
    50                  55                  60                  


Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln 
65                  70                  75                  80  


Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn 
                85                  90                  95      


Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu 
            100                 105                 110         


Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln 
        115                 120                 125             


Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr 
    130                 135                 140                 


Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu 
145                 150                 155                 160 


Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn 
                165                 170                 175     


Pro Gly Glu Phe Cys Val Leu 
            180             


<210>  18
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  18
tctaagtacg gccctccctg ccctagctgt cccgcccctg aatttctggg cggaccctcc       60

gtgtttctgt tccccccaaa gcccaaggac accctgatga tcagccggac ccccgaagtg      120

acctgtgtgg tggtggatgt gtcccaggaa gatcccgagg tgcagttcaa ttggtacgtg      180

gacggggtgg aagtgcacaa cgccaagacc aagcccagag aggaacagtt caacagcacc      240

taccgggtgg tgtctgtgct gaccgtgctg caccaggatt ggctgagcgg caaagagtac      300

aagtgcaagg tgtccagcaa gggcctgccc agcagcatcg aaaagaccat cagcaacgcc      360

accggccagc ccagggaacc ccaggtgtac acactgcccc ctagccagga agagatgacc      420

aagaaccagg tgtccctgac atgcctcgtg aagggcttct acccctccga tatcgccgtg      480

gaatgggaga gcaacggcca gccagagaac aactacaaga ccaccccccc agtgctggac      540

agcgacggct cattcttcct gtactcccgg ctgacagtgg acaagagcag ctggcaggaa      600

ggcaacgtgt tcagctgcag cgtgatgcac gaagccctgc acaaccacta cacccagaag      660

tccctgagcc tgtccctggg caaa                                             684


<210>  19
<211>  867
<212>  DNA
<213>  Homo sapiens

<400>  19
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc      540

ctggtgctgc tagtctgggt cctggccgtc atctgctccc gggccgcacg agggacaata      600

ggagccaggc gcaccggcca gcccctgaag gaggacccct cagccgtgcc tgtgttctct      660

gtggactatg gggagctgga tttccagtgg cgagagaaga ccccggagcc ccccgtgccc      720

tgtgtccctg agcagacgga gtatgccacc attgtctttc ctagcggaat gggcacctca      780

tcccccgccc gcaggggctc agctgacggc cctcggagtg cccagccact gaggcctgag      840

gatggacact gctcttggcc cctctga                                          867


<210>  20
<211>  1623
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  20
gtcgacgcca ccatgcagat cccacaggcg ccctggccag tcgtctgggc ggtgctacaa       60

ctgggctggc ggccaggatg gttcttagac tccccagaca ggccctggaa cccccccacc      120

ttctccccag ccctgctcgt ggtgaccgaa ggggacaacg ccaccttcac ctgcagcttc      180

tccaacacat cggagagctt cgtgctaaac tggtaccgca tgagccccag caaccagacg      240

gacaagctgg ccgccttccc cgaggaccgc agccagcccg gccaggactg ccgcttccgt      300

gtcacacaac tgcccaacgg gcgtgacttc cacatgagcg tggtcagggc ccggcgcaat      360

gacagcggca cctacctctg tggggccatc tccctggccc ccaaggcgca gatcaaagag      420

agcctgcggg cagagctcag ggtgacagag agaagggcag aagtgcccac agcccacccc      480

agcccctcac ccaggccagc cggccagttc caatctaagt acggccctcc ctgccctagc      540

tgtcccgccc ctgaatttct gggcggaccc tccgtgtttc tgttcccccc aaagcccaag      600

gacaccctga tgatcagccg gacccccgaa gtgacctgtg tggtggtgga tgtgtcccag      660

gaagatcccg aggtgcagtt caattggtac gtggacgggg tggaagtgca caacgccaag      720

accaagccca gagaggaaca gttcaacagc acctaccggg tggtgtctgt gctgaccgtg      780

ctgcaccagg attggctgag cggcaaagag tacaagtgca aggtgtccag caagggcctg      840

cccagcagca tcgaaaagac catcagcaac gccaccggcc agcccaggga accccaggtg      900

tacacactgc cccctagcca ggaagagatg accaagaacc aggtgtccct gacatgcctc      960

gtgaagggct tctacccctc cgatatcgcc gtggaatggg agagcaacgg ccagccagag     1020

aacaactaca agaccacccc cccagtgctg gacagcgacg gctcattctt cctgtactcc     1080

cggctgacag tggacaagag cagctggcag gaaggcaacg tgttcagctg cagcgtgatg     1140

cacgaagccc tgcacaacca ctacacccag aagtccctga gcctgtccct gggcaaaata     1200

gagggacgaa tggaccaggt atcacatcgg tatcctcgaa ttcaaagtat caaagtacaa     1260

tttaccgaat ataagaagga gaaaggtttc atcctcactt cccaaaagga ggatgaaatc     1320

atgaaggtgc agaacaactc agtcatcatc aactgtgatg ggttttatct catctccctg     1380

aagggctact tctcccagga agtcaacatt agccttcatt accagaagga tgaggagccc     1440

ctcttccaac tgaagaaggt caggtctgtc aactccttga tggtggcctc tctgacttac     1500

aaagacaaag tctacttgaa tgtgaccact gacaatacct ccctggatga cttccatgtg     1560

aatggcggag aactgattct tatccatcaa aatcctggtg aattctgtgt cctttgagtc     1620

gac                                                                   1623


<210>  21
<211>  1637
<212>  DNA
<213>  Homo sapiens

<400>  21
caccggcgag atctgccacc atgcagatcc ctcaggcccc ctggcctgtc gtgtgggctg       60

tgctgcagct gggatggcgg cctggctggt tcctggactc tcctgacaga ccctggaacc      120

cccccacctt tagccctgct ctgctggtcg tgaccgaggg cgacaacgcc accttcacct      180

gttccttcag caacacctcc gagtccttcg tgctgaactg gtacagaatg tcccccagca      240

accagaccga caagctggcc gccttccccg aggatagatc ccagcctgga caggactgcc      300

ggttcagagt gacccagctg cccaacggcc gggacttcca catgtctgtc gtgcgggcca      360

gacggaacga ctccggcaca tatctgtgcg gcgccatctc cctggccccc aaggctcaga      420

tcaaagagtc tctgcgggcc gagctgagag tgaccgagag aagggctgag gtgccaaccg      480

cccaccctag cccatctcca agacctgccg gccagttcca gtctaagtac ggccctcctt      540

gccctagctg ccctgcccct gaatttctgg gcggaccctc cgtgttcctg ttccccccaa      600

agcccaagga caccctgatg atctcccgga cccccgaagt gacctgcgtg gtggtggatg      660

tgtcccagga agatcccgag gtgcagttca attggtacgt ggacggcgtg gaagtgcaca      720

acgccaagac caagcccaga gaggaacagt tcaactccac ctaccgggtg gtgtccgtgc      780

tgaccgtgct gcaccaggat tggctgtccg gcaaagagta caagtgcaag gtgtcctcca      840

agggcctgcc ctccagcatc gaaaagacca tctctaacgc caccggccag ccccgggaac      900

cccaggtgta cacactgcct ccaagccagg aagagatgac caagaaccag gtgtccctga      960

cctgtctcgt gaagggcttc tacccctccg atatcgccgt ggaatgggag tccaacggcc     1020

agcctgagaa caactacaag accacccccc ctgtgctgga ctccgacggc tccttcttcc     1080

tgtactcccg cctgaccgtg gacaagtcct cctggcagga aggcaacgtg ttctcctgct     1140

ccgtgatgca cgaggccctg cacaaccact acacccagaa gtccctgtcc ctgtctctgg     1200

gcaagatcga gggccggatg gatcaggtgt cacacagata cccccggatc cagtccatca     1260

aagtgcagtt taccgagtac aagaaagaga agggattcat cctgacctcc cagaaagagg     1320

acgagatcat gaaggtgcag aacaactccg tgatcatcaa ctgcgacggg ttctacctga     1380

tctccctgaa gggctacttc agtcaggaag tgaacatcag cctgcactac cagaaggacg     1440

aggaacccct gttccagctg aagaaagtgc ggagcgtgaa ctccctgatg gtggcctctc     1500

tgacctacaa ggacaaggtg tacctgaacg tgaccaccga caatacctcc ctggacgact     1560

tccacgtgaa cggcggcgag ctgatcctga tccaccagaa ccctggcgag ttctgcgtgc     1620

tgtgactcga ggctagc                                                    1637


<210>  22
<211>  534
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  22

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Ser Lys Tyr Gly Pro Pro Cys Pro Ser 
                165                 170                 175     


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            180                 185                 190         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        195                 200                 205             


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
    210                 215                 220                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
225                 230                 235                 240 


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                245                 250                 255     


Leu His Gln Asp Trp Leu Ser Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            260                 265                 270         


Ser Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Asn Ala Thr 
        275                 280                 285             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
    290                 295                 300                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
305                 310                 315                 320 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                325                 330                 335     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            340                 345                 350         


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Ser Trp Gln Glu Gly 
        355                 360                 365             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    370                 375                 380                 


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ile Glu Gly Arg Met 
385                 390                 395                 400 


Asp Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln 
                405                 410                 415     


Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys 
            420                 425                 430         


Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys 
        435                 440                 445             


Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val 
    450                 455                 460                 


Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu 
465                 470                 475                 480 


Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr 
                485                 490                 495     


Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp 
            500                 505                 510         


Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro 
        515                 520                 525             


Gly Glu Phe Cys Val Leu 
    530                 


<210>  23
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  23

Gly Gly Gly Gly Ser 
1               5   


<210>  24
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  24

Glu Ala Ala Ala Lys 
1               5   


<210>  25
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  25

Ala Glu Ala Ala Ala Lys Ala 
1               5           


<210>  26
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  26

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          


<210>  27
<211>  46
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  27

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Ala Leu Glu Ala Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
        35                  40                  45      


<210>  28
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  28

Pro Ala Pro Ala Pro 
1               5   


<210>  29
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  29

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  30
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  30

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  


<210>  31
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  31

Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210>  32
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  32

Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala 
1               5                   10                  15      


Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe 
            20                  25                  30          


Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro 
        35                  40                  45              


Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln 
    50                  55                  60                  


Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg 
65                  70                  75                  80  


Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr 
                85                  90                  95      


Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu 
            100                 105                 110         


Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro 
        115                 120                 125             


Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln 
    130                 135                 140             


<210>  33
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  33

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala 
        115                 120                 125             


Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly 
    130                 135                 140                 


Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu 
145                 150                 155                 160 


Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser 
                165                 170                 175     


Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val 
            180                 185                 190         


His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp 
        195                 200                 205             


Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro 
    210                 215                 220                 


Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn 
225                 230                 235                 240 


Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr 
                245                 250                 255     


Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val 
            260                 265                 270         


Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val 
        275                 280                 285             


Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu 
    290                 295                 300                 


His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser 
305                 310                 315                 320 


Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly 
                325                 330                 335     


Ser Asn Glu Arg Asn Ile Tyr 
            340             


<210>  34
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  34

Lys Glu Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His 
1               5                   10                  15      


Ser Ile Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr 
            20                  25                  30          


Cys Ala Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr 
        35                  40                  45              


Cys Val Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn 
    50                  55                  60                  


Ile Ser Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn 
65                  70                  75                  80  


Gly Ser Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser 
                85                  90                  95      


His Ser Thr Thr Leu Tyr Val Thr Asp Val Lys Ser Ala Ser Glu Arg 
            100                 105                 110         


Pro Ser Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu Tyr Arg 
        115                 120                 125         


<210>  35
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys 
1               5                   10                  15      


Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln 
            20                  25                  30          


Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Cys 
        35                  40                  45              


Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val 
    50                  55                  60                  


Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn 
65                  70                  75                  80  


Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr 
                85                  90                  95      


Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu 
            100                 105                 110         


His Gly Ala Arg Phe Gln Ile Pro 
        115                 120 


<210>  36
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  36

Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln Asn Ala Tyr Leu Pro 
1               5                   10                  15      


Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu Val Pro Val Cys Trp 
            20                  25                  30          


Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly Asn Val Val Leu Arg 
        35                  40                  45              


Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser Arg Tyr Trp Leu Asn 
    50                  55                  60                  


Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr Ile Glu Asn Val Thr 
65                  70                  75                  80  


Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile Gln Ile Pro Gly Ile 
                85                  90                  95      


Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val Ile Lys Pro Ala Lys 
            100                 105                 110         


Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe Thr Ala Ala Phe Pro 
        115                 120                 125             


Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala Glu Thr Gln Thr Leu 
    130                 135                 140                 


Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile Ser Thr Leu Ala Asn 
145                 150                 155                 160 


Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu Arg Asp Ser Gly Ala 
                165                 170                 175     


Thr Ile Arg Ile Gly 
            180     


<210>  37
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  37

Gln Val Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr Pro 
1               5                   10                  15      


Ala Ser Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile Val 
            20                  25                  30          


Thr Trp Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Phe 
        35                  40                  45              


Ser Glu Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile 
    50                  55                  60                  


Asn Ile Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn 
65                  70                  75                  80  


Ile Thr Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe 
                85                  90                  95      


Gly Phe Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val Gln 
            100                 105                 110         


Pro Ile Val Ser Leu His Tyr Lys Phe Ser Glu Asp His Leu Asn Ile 
        115                 120                 125             


Thr Cys Ser Ala Thr Ala Arg Pro Ala Pro Met Val Phe Trp Lys Val 
    130                 135                 140                 


Pro Arg Ser Gly Ile Glu Asn Ser Thr Val Thr Leu Ser His Pro Asn 
145                 150                 155                 160 


Gly Thr Thr Ser Val Thr Ser Ile Leu His Ile Lys Asp Pro Lys Asn 
                165                 170                 175     


Gln Val Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr Val 
            180                 185                 190         


Thr Asp Phe Lys Gln Thr Val Asn Lys Gly 
        195                 200         


<210>  38
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  38

Leu Ser Val Gln Gln Gly Pro Asn Leu Leu Gln Val Arg Gln Gly Ser 
1               5                   10                  15      


Gln Ala Thr Leu Val Cys Gln Val Asp Gln Ala Thr Ala Trp Glu Arg 
            20                  25                  30          


Leu Arg Val Lys Trp Thr Lys Asp Gly Ala Ile Leu Cys Gln Pro Tyr 
        35                  40                  45              


Ile Thr Asn Gly Ser Leu Ser Leu Gly Val Cys Gly Pro Gln Gly Arg 
    50                  55                  60                  


Leu Ser Trp Gln Ala Pro Ser His Leu Thr Leu Gln Leu Asp Pro Val 
65                  70                  75                  80  


Ser Leu Asn His Ser Gly Ala Tyr Val Cys Trp Ala Ala Val Glu Ile 
                85                  90                  95      


Pro Glu Leu Glu Glu Ala Glu Gly Asn Ile Thr Arg Leu Phe Val Asp 
            100                 105                 110         


Pro Asp Asp Pro Thr Gln Asn Arg Asn Arg Ile Ala Ser Phe Pro Gly 
        115                 120                 125             


<210>  39
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  39

Phe Lys Val Ala Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
1               5                   10                  15      


Asn Val Thr Leu Thr Cys Arg Leu Leu Gly Pro Val Asp Lys Gly His 
            20                  25                  30          


Asp Val Thr Phe Tyr Lys Thr Trp Tyr Arg Ser Ser Arg Gly Glu Val 
        35                  40                  45              


Gln Thr Cys Ser Glu Arg Arg Pro Ile Arg Asn Leu Thr Phe Gln Asp 
    50                  55                  60                  


Leu His Leu His His Gly Gly His Gln Ala Ala Asn Thr Ser His Asp 
65                  70                  75                  80  


Leu Ala Gln Arg His Gly Leu Glu Ser Ala Ser Asp His His Gly Asn 
                85                  90                  95      


Phe Ser Ile Thr Met Arg Asn Leu Thr Leu Leu Asp Ser Gly Leu Tyr 
            100                 105                 110         


Cys Cys Leu Val Val Glu Ile Arg His His His Ser Glu His Arg Val 
        115                 120                 125             


His Gly Ala Met Glu Leu Gln Val Gln Thr Gly Lys Asp Ala Pro Ser 
    130                 135                 140                 


Asn Cys Val Val Tyr Pro Ser Ser Ser Gln Asp Ser Glu Asn Ile Thr 
145                 150                 155                 160 


Ala Ala 
        


<210>  40
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  40

Val Arg Ile Asn Gly Asp Gly Gln Glu Val Leu Tyr Leu Ala Glu Gly 
1               5                   10                  15      


Asp Asn Val Arg Leu Gly Cys Pro Tyr Val Leu Asp Pro Glu Asp Tyr 
            20                  25                  30          


Gly Pro Asn Gly Leu Asp Ile Glu Trp Met Gln Val Asn Ser Asp Pro 
        35                  40                  45              


Ala His His Arg Glu Asn Val Phe Leu Ser Tyr Gln Asp Lys Arg Ile 
    50                  55                  60                  


Asn His Gly Ser Leu Pro His Leu Gln Gln Arg Val Arg Phe Ala Ala 
65                  70                  75                  80  


Ser Asp Pro Ser Gln Tyr Asp Ala Ser Ile Asn Leu Met Asn Leu Gln 
                85                  90                  95      


Val Ser Asp Thr Ala Thr Tyr Glu Cys Arg Val Lys Lys Thr Thr Met 
            100                 105                 110         


Ala Thr Arg Lys Val Ile Val Thr Val Gln Ala Arg Pro Ala Val Pro 
        115                 120                 125             


Met Cys Trp Thr Glu Gly His Met Thr Tyr Gly Asn Asp Val Val Leu 
    130                 135                 140                 


Lys Cys Tyr Ala Ser Gly Gly Ser Gln Pro Leu Ser Tyr Lys Trp Ala 
145                 150                 155                 160 


Lys Ile Ser Gly His His Tyr Pro Tyr Arg Ala Gly Ser Tyr Thr Ser 
                165                 170                 175     


Gln His Ser Tyr His Ser Glu Leu Ser Tyr Gln Glu Ser Phe His Ser 
            180                 185                 190         


Ser Ile Asn Gln Gly Leu Asn Asn Gly Asp Leu Val Leu Lys Asp Ile 
        195                 200                 205             


Ser Arg Ala Asp Asp Gly Leu Tyr Gln Cys Thr Val Ala Asn Asn Val 
    210                 215                 220                 


Gly Tyr Ser Val Cys Val Val Glu Val Lys Val Ser Asp Ser Arg Arg 
225                 230                 235                 240 


Ile Gly 
        


<210>  41
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  41

Glu Asp Phe Arg Val Ile Gly Pro Ala His Pro Ile Leu Ala Gly Val 
1               5                   10                  15      


Gly Glu Asp Ala Leu Leu Thr Cys Gln Leu Leu Pro Lys Arg Thr Thr 
            20                  25                  30          


Met His Val Glu Val Arg Trp Tyr Arg Ser Glu Pro Ser Thr Pro Val 
        35                  40                  45              


Phe Val His Arg Asp Gly Val Glu Val Thr Glu Met Gln Met Glu Glu 
    50                  55                  60                  


Tyr Arg Gly Trp Val Glu Trp Ile Glu Asn Gly Ile Ala Lys Gly Asn 
65                  70                  75                  80  


Val Ala Leu Lys Ile His Asn Ile Gln Pro Ser Asp Asn Gly Gln Tyr 
                85                  90                  95      


Trp Cys His Phe Gln Asp Gly Asn Tyr Cys Gly Glu Thr Ser Leu Leu 
            100                 105                 110         


Leu Lys Val Ala Gly Leu Gly Ser Ala Pro Ser Ile His Met Glu Gly 
        115                 120                 125             


Pro Gly Glu Ser Gly Val Gln Leu Val Cys Thr Ala Arg Gly Trp Phe 
    130                 135                 140                 


Pro Glu Pro Gln Val Tyr Trp Glu Asp Ile Arg Gly Glu Lys Leu Leu 
145                 150                 155                 160 


Ala Val Ser Glu His Arg Ile Gln Asp Lys Asp Gly Leu Phe Tyr Ala 
                165                 170                 175     


Glu Ala Thr Leu Val Val Arg Asn Ala Ser Ala Glu Ser Val Ser Cys 
            180                 185                 190         


Leu Val His Asn Pro Val Leu Thr Glu Glu Lys Gly Ser Val Ile Ser 
        195                 200                 205             


Leu Pro Glu Lys Leu Gln Thr Glu Leu Ala Ser Leu Lys Val Asn Gly 
    210                 215                 220                 


Pro Ser Gln Pro Ile Leu Val Arg Val Gly Glu Asp Ile Gln Leu Thr 
225                 230                 235                 240 


Cys Tyr Leu Ser Pro Lys Ala Asn Ala Gln Ser Met Glu Val Arg Trp 
                245                 250                 255     


Asp Arg Ser His Arg Tyr Pro Ala Val His Val Tyr Met Asp Gly Asp 
            260                 265                 270         


His Val Ala Gly Glu Gln Met Ala Glu Tyr Arg Gly Arg Thr Val Leu 
        275                 280                 285             


Val Ser Asp Ala Ile Asp Glu Gly Arg Leu Thr Leu Gln Ile Leu Ser 
    290                 295                 300                 


Ala Arg Pro Ser Asp Asp Gly Gln Tyr Arg Cys Leu Phe Glu Lys Asp 
305                 310                 315                 320 


Asp Val Tyr Gln Glu Ala Ser Leu Asp Leu Lys Val Val Ser Leu Gly 
                325                 330                 335     


Ser Ser Pro Leu Ile Thr Val Glu Gly Gln Glu Asp Gly Glu Met Gln 
            340                 345                 350         


Pro Met Cys Ser Ser Asp Gly Trp Phe Pro Gln Pro His Val Pro Trp 
        355                 360                 365             


Arg Asp Met Glu Gly Lys Thr Ile Pro Ser Ser Ser Gln Ala Leu Thr 
    370                 375                 380                 


Gln Gly Ser His Gly Leu Phe His Val Gln Thr Leu Leu Arg Val Thr 
385                 390                 395                 400 


Asn Ile Ser Ala Val Asp Val Thr Cys Ser Ile Ser Ile Pro Phe Leu 
                405                 410                 415     


Gly Glu Glu Lys Ile Ala Thr Phe Ser Leu Ser 
            420                 425         


<210>  42
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  42

Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr Ala Pro Glu Pro Gly Ser 
1               5                   10                  15      


Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln Thr Ala Gln Met Cys Cys 
            20                  25                  30          


Ser Lys Cys Ser Pro Gly Gln His Ala Lys Val Phe Cys Thr Lys Thr 
        35                  40                  45              


Ser Asp Thr Val Cys Asp Ser Cys Glu Asp Ser Thr Tyr Thr Gln Leu 
    50                  55                  60                  


Trp Asn Trp Val Pro Glu Cys Leu Ser Cys Gly Ser Arg Cys Ser Ser 
65                  70                  75                  80  


Asp Gln Val Glu Thr Gln Ala Cys Thr Arg Glu Gln Asn Arg Ile Cys 
                85                  90                  95      


Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu Ser Lys Gln Glu Gly Cys 
            100                 105                 110         


Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg Pro Gly Phe Gly Val Ala 
        115                 120                 125             


Arg Pro Gly Thr Glu Thr Ser Asp Val Val Cys Lys Pro Cys Ala Pro 
    130                 135                 140                 


Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr Asp Ile Cys Arg Pro His 
145                 150                 155                 160 


Gln Ile Cys Asn Val Val Ala Ile Pro Gly Asn Ala Ser Met Asp Ala 
                165                 170                 175     


Val Cys Thr Ser Thr Ser Pro Thr Arg Ser Met Ala Pro Gly Ala Val 
            180                 185                 190         


His Leu Pro Gln Pro Val Ser Thr Arg Ser Gln His Thr Gln Pro Thr 
        195                 200                 205             


Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser Phe Leu Leu Pro Met Gly 
    210                 215                 220                 


Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly Asp 
225                 230                 235 


<210>  43
<211>  438
<212>  PRT
<213>  Homo sapiens

<400>  43

Leu Glu Val Gln Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr 
1               5                   10                  15      


Asp Ala Thr Leu Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu 
            20                  25                  30          


Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val 
        35                  40                  45              


His Ser Phe Ala Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg 
    50                  55                  60                  


Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg 
65                  70                  75                  80  


Leu Gln Arg Val Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val 
                85                  90                  95      


Ser Ile Arg Asp Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala 
            100                 105                 110         


Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg 
        115                 120                 125             


Pro Gly Asp Thr Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro 
    130                 135                 140                 


Glu Ala Glu Val Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly 
145                 150                 155                 160 


Asn Val Thr Thr Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val 
                165                 170                 175     


His Ser Ile Leu Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys 
            180                 185                 190         


Leu Val Arg Asn Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr 
        195                 200                 205             


Ile Thr Pro Gln Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro 
    210                 215                 220                 


Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys 
225                 230                 235                 240 


Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile 
                245                 250                 255     


Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly 
            260                 265                 270         


Arg Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp 
        275                 280                 285             


Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val 
    290                 295                 300                 


Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly 
305                 310                 315                 320 


Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser 
                325                 330                 335     


Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr 
            340                 345                 350         


Ile Thr Cys Ser Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp 
        355                 360                 365             


Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln 
    370                 375                 380                 


Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val 
385                 390                 395                 400 


Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val 
                405                 410                 415     


Leu Gln Gln Asp Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Met 
            420                 425                 430         


Thr Phe Pro Pro Glu Ala 
        435             


<210>  44
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  44

Cys Gln Gly Ser Ala Asp His Val Val Ser Ile Ser Gly Val Pro Leu 
1               5                   10                  15      


Gln Leu Gln Pro Asn Ser Ile Gln Thr Lys Val Asp Ser Ile Ala Trp 
            20                  25                  30          


Lys Lys Leu Leu Pro Ser Gln Asn Gly Phe His His Ile Leu Lys Trp 
        35                  40                  45              


Glu Asn Gly Ser Leu Pro Ser Asn Thr Ser Asn Asp Arg Phe Ser Phe 
    50                  55                  60                  


Ile Val Lys Asn Leu Ser Leu Leu Ile Lys Ala Ala Gln Gln Gln Asp 
65                  70                  75                  80  


Ser Gly Leu Tyr Cys Leu Glu Val Thr Ser Ile Ser Gly Lys Val Gln 
                85                  90                  95      


Thr Ala Thr Phe Gln Val Phe Val Phe Glu Ser Leu Leu Pro Asp Lys 
            100                 105                 110         


Val Glu Lys Pro Arg Leu Gln Gly Gln Gly Lys Ile Leu Asp Arg Gly 
        115                 120                 125             


Arg Cys Gln Val Ala Leu Ser Cys Leu Val Ser Arg Asp Gly Asn Val 
    130                 135                 140                 


Ser Tyr Ala Trp Tyr Arg Gly Ser Lys Leu Ile Gln Thr Ala Gly Asn 
145                 150                 155                 160 


Leu Thr Tyr Leu Asp Glu Glu Val Asp Ile Asn Gly Thr His Thr Tyr 
                165                 170                 175     


Thr Cys Asn Val Ser Asn Pro Val Ser Trp Glu Ser His Thr Leu Asn 
            180                 185                 190         


Leu Thr Gln Asp Cys Gln Asn Ala His Gln Glu Phe Arg Phe Trp Pro 
        195                 200                 205             


<210>  45
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  45

Val Pro Val Val Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys 
1               5                   10                  15      


Ser Pro Thr Ile Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly 
            20                  25                  30          


Val Thr Trp Gln His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro 
        35                  40                  45              


Gly His Pro Leu Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp 
    50                  55                  60                  


Gly Pro Arg Pro Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly 
65                  70                  75                  80  


Leu Arg Ser Gly Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu 
                85                  90                  95      


Arg Gly Arg Gln Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg 
            100                 105                 110         


Arg Ala Asp Ala Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg 
        115                 120                 125             


Ala Leu Ser Cys Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr 
    130                 135                 140                 


Ala Ser Pro Pro Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn 
145                 150                 155                 160 


Cys Ser Phe Ser Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg 
                165                 170                 175     


Asn Arg Gly Gln Gly Arg Val Pro Val Arg Glu Ser Pro His His His 
            180                 185                 190         


Leu Ala Glu Ser Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser 
        195                 200                 205             


Gly Pro Trp Gly Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser 
    210                 215                 220                 


Ile Met Tyr Asn Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu 
225                 230                 235                 240 


Thr Val Tyr Ala Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu 
                245                 250                 255     


Pro Ala Gly Val Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro 
            260                 265                 270         


Pro Gly Gly Gly Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe 
        275                 280                 285             


Thr Leu Arg Leu Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr 
    290                 295                 300                 


Cys His Ile His Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu 
305                 310                 315                 320 


Ala Ile Ile Thr Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu 
                325                 330                 335     


Gly Lys Leu Leu Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe 
            340                 345                 350         


Val Trp Ser Ser Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro 
        355                 360                 365             


Trp Leu Glu Ala Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys 
    370                 375                 380                 


Gln Leu Tyr Gln Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr 
385                 390                 395                 400 


Glu Leu Ser Ser Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala 
                405                 410                 415     


Leu Pro Ala Gly His Leu 
            420         


<210>  46
<211>  498
<212>  PRT
<213>  Homo sapiens

<400>  46

Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val Lys Pro Gly 
1               5                   10                  15      


Ala Thr Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val Glu Trp Asp 
            20                  25                  30          


Gly Pro Pro Ser Pro His Trp Thr Leu Tyr Ser Asp Gly Ser Ser Ser 
        35                  40                  45              


Ile Leu Ser Thr Asn Asn Ala Thr Phe Gln Asn Thr Gly Thr Tyr Arg 
    50                  55                  60                  


Cys Thr Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala Ile His Leu 
65                  70                  75                  80  


Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala Gln Glu Val 
                85                  90                  95      


Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu Leu Thr Asp 
            100                 105                 110         


Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg Gly Arg Pro 
        115                 120                 125             


Leu Met Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His Gly Phe Thr 
    130                 135                 140                 


Ile His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln Cys Ser Ala 
145                 150                 155                 160 


Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg Leu Lys Val 
                165                 170                 175     


Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val Pro Ala Glu 
            180                 185                 190         


Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys Ser Ala Ser 
        195                 200                 205             


Ser Val Asp Val Asn Phe Asp Val Phe Leu Gln His Asn Asn Thr Lys 
    210                 215                 220                 


Leu Ala Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg Tyr Gln Lys 
225                 230                 235                 240 


Val Leu Thr Leu Asn Leu Asp Gln Val Asp Phe Gln His Ala Gly Asn 
                245                 250                 255     


Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser Thr Ser Met 
            260                 265                 270         


Phe Phe Arg Val Val Glu Ser Ala Tyr Leu Asn Leu Ser Ser Glu Gln 
        275                 280                 285             


Asn Leu Ile Gln Glu Val Thr Val Gly Glu Gly Leu Asn Leu Lys Val 
    290                 295                 300                 


Met Val Glu Ala Tyr Pro Gly Leu Gln Gly Phe Asn Trp Thr Tyr Leu 
305                 310                 315                 320 


Gly Pro Phe Ser Asp His Gln Pro Glu Pro Lys Leu Ala Asn Ala Thr 
                325                 330                 335     


Thr Lys Asp Thr Tyr Arg His Thr Phe Thr Leu Ser Leu Pro Arg Leu 
            340                 345                 350         


Lys Pro Ser Glu Ala Gly Arg Tyr Ser Phe Leu Ala Arg Asn Pro Gly 
        355                 360                 365             


Gly Trp Arg Ala Leu Thr Phe Glu Leu Thr Leu Arg Tyr Pro Pro Glu 
    370                 375                 380                 


Val Ser Val Ile Trp Thr Phe Ile Asn Gly Ser Gly Thr Leu Leu Cys 
385                 390                 395                 400 


Ala Ala Ser Gly Tyr Pro Gln Pro Asn Val Thr Trp Leu Gln Cys Ser 
                405                 410                 415     


Gly His Thr Asp Arg Cys Asp Glu Ala Gln Val Leu Gln Val Trp Asp 
            420                 425                 430         


Asp Pro Tyr Pro Glu Val Leu Ser Gln Glu Pro Phe His Lys Val Thr 
        435                 440                 445             


Val Gln Ser Leu Leu Thr Val Glu Thr Leu Glu His Asn Gln Thr Tyr 
    450                 455                 460                 


Glu Cys Arg Ala His Asn Ser Val Gly Ser Gly Ser Trp Ala Phe Ile 
465                 470                 475                 480 


Pro Ile Ser Ala Gly Ala His Thr His Pro Pro Asp Glu Phe Leu Phe 
                485                 490                 495     


Thr Pro 
        


<210>  47
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  47

Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys Val 
1               5                   10                  15      


Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys Val 
            20                  25                  30          


Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg Asp 
        35                  40                  45              


Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr Thr 
    50                  55                  60                  


Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro Thr 
65                  70                  75                  80  


Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu 
                85                  90              


<210>  48
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  48

His Gly Thr Glu Leu Pro Ser Pro Pro Ser Val Trp Phe Glu Ala Glu 
1               5                   10                  15      


Phe Phe His His Ile Leu His Trp Thr Pro Ile Pro Asn Gln Ser Glu 
            20                  25                  30          


Ser Thr Cys Tyr Glu Val Ala Leu Leu Arg Tyr Gly Ile Glu Ser Trp 
        35                  40                  45              


Asn Ser Ile Ser Asn Cys Ser Gln Thr Leu Ser Tyr Asp Leu Thr Ala 
    50                  55                  60                  


Val Thr Leu Asp Leu Tyr His Ser Asn Gly Tyr Arg Ala Arg Val Arg 
65                  70                  75                  80  


Ala Val Asp Gly Ser Arg His Ser Asn Trp Thr Val Thr Asn Thr Arg 
                85                  90                  95      


Phe Ser Val Asp Glu Val Thr Leu Thr Val Gly Ser Val Asn Leu Glu 
            100                 105                 110         


Ile His Asn Gly Phe Ile Leu Gly Lys Ile Gln Leu Pro Arg Pro Lys 
        115                 120                 125             


Met Ala Pro Ala Asn Asp Thr Tyr Glu Ser Ile Phe Ser His Phe Arg 
    130                 135                 140                 


Glu Tyr Glu Ile Ala Ile Arg Lys Val Pro Gly Asn Phe Thr Phe Thr 
145                 150                 155                 160 


His Lys Lys Val Lys His Glu Asn Phe Ser Leu Leu Thr Ser Gly Glu 
                165                 170                 175     


Val Gly Glu Phe Cys Val Gln Val Lys Pro Ser Val Ala Ser Arg Ser 
            180                 185                 190         


Asn Lys Gly Met Trp Ser Lys Glu Glu Cys Ile Ser Leu Thr Arg Gln 
        195                 200                 205             


Tyr Phe Thr Val Thr Asn 
    210                 


<210>  49
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  49

Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu Ile Asn Ser Gln 
1               5                   10                  15      


Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val Ser Asp Cys Thr 
            20                  25                  30          


Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu Ser Glu Phe Leu 
        35                  40                  45              


Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His Lys Tyr Cys Asp 
    50                  55                  60                  


Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr Ser Glu Thr Asp 
65                  70                  75                  80  


Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr Ser Glu Ala Cys 
                85                  90                  95      


Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly Phe Gly Val Lys 
            100                 105                 110         


Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu Pro Cys Pro Val 
        115                 120                 125             


Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys Cys His Pro Trp 
    130                 135                 140                 


Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln Ala Gly Thr Asn 
145                 150                 155                 160 


Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu Arg 
                165                 170             


<210>  50
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  50

Leu His Cys Val Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His 
1               5                   10                  15      


Glu Cys Arg Pro Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln 
            20                  25                  30          


Asn Thr Val Cys Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val 
        35                  40                  45              


Ser Ser Lys Pro Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly 
    50                  55                  60                  


Ser Glu Arg Lys Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg 
65                  70                  75                  80  


Cys Arg Ala Gly Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp 
                85                  90                  95      


Cys Ala Pro Cys Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala 
            100                 105                 110         


Cys Lys Pro Trp Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln 
        115                 120                 125             


Pro Ala Ser Asn Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro 
    130                 135                 140                 


Ala Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr 
145                 150                 155                 160 


Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr 
                165                 170                 175     


Arg Pro Val Glu Val Pro Gly Gly Arg Ala 
            180                 185     


<210>  51
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  51

Leu Gln Asp Pro Cys Ser Asn Cys Pro Ala Gly Thr Phe Cys Asp Asn 
1               5                   10                  15      


Asn Arg Asn Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser Phe Ser Ser 
            20                  25                  30          


Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys Lys Gly Val 
        35                  40                  45              


Phe Arg Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala Glu Cys Asp 
    50                  55                  60                  


Cys Thr Pro Gly Phe His Cys Leu Gly Ala Gly Cys Ser Met Cys Glu 
65                  70                  75                  80  


Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys Asp 
                85                  90                  95      


Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly Thr 
        115                 120                 125             


Lys Glu Arg Asp Val Val Cys Gly Pro Ser Pro Ala Asp Leu Ser Pro 
    130                 135                 140                 


Gly Ala Ser Ser Val Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His 
145                 150                 155                 160 


Ser Pro Gln 
            


<210>  52
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  52

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  53
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  53

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  54
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  54

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  55
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  55

Leu Ile Ile Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
1               5                   10                  15      


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
            20                  25                  30          


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
        35                  40                  45              


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
    50                  55                  60                  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
65                  70                  75                  80  


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
                85                  90                  95      


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
            100                 105                 110         


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
        115                 120                 125             


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
    130                 135                 140                 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
145                 150                 155                 160 


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
                165                 170                 175     


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
            180                 185                 190         


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
        195                 200                 205             


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
    210                 215                 220                 


Ser His Leu Gln Leu Leu Asn Ser Lys Ala Ser 
225                 230                 235 


<210>  56
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  56

Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe 
1               5                   10                  15      


Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu 
            20                  25                  30          


Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp 
        35                  40                  45              


Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn 
    50                  55                  60                  


Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys 
65                  70                  75                  80  


Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys 
                85                  90                  95      


Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
            100                 105                 110         


Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly 
        115                 120                 125             


Glu Phe Cys Val Leu 
    130             


<210>  57
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  57

Thr Ser Leu Lys Pro Thr Ala Ile Glu Ser Cys Met Val Lys Phe Glu 
1               5                   10                  15      


Leu Ser Ser Ser Lys Trp His Met Thr Ser Pro Lys Pro His Cys Val 
            20                  25                  30          


Asn Thr Thr Ser Asp Gly Lys Leu Lys Ile Leu Gln Ser Gly Thr Tyr 
        35                  40                  45              


Leu Ile Tyr Gly Gln Val Ile Pro Val Asp Lys Lys Tyr Ile Lys Asp 
    50                  55                  60                  


Asn Ala Pro Phe Val Val Gln Ile Tyr Lys Lys Asn Asp Val Leu Gln 
65                  70                  75                  80  


Thr Leu Met Asn Asp Phe Gln Ile Leu Pro Ile Gly Gly Val Tyr Glu 
                85                  90                  95      


Leu His Ala Gly Asp Asn Ile Tyr Leu Lys Phe Asn Ser Lys Asp His 
            100                 105                 110         


Ile Gln Lys Thr Asn Thr Tyr Trp Gly Ile Ile Leu Met Pro Asp Leu 
        115                 120                 125             


Pro Phe Ile Ser 
    130         


<210>  58
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  58

Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
1               5                   10                  15      


Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
            20                  25                  30          


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
        35                  40                  45              


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
    50                  55                  60                  


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
65                  70                  75                  80  


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
                85                  90                  95      


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
            100                 105                 110         


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
        115                 120                 125             


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
    130                 135                 140                 


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
145                 150                 155                 160 


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
                165                 170                 175     


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
            180                 185                 190         


Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        195                 200                 205 


<210>  59
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  59

Ser Gln Leu Arg Ala Gln Gly Glu Ala Cys Val Gln Phe Gln Ala Leu 
1               5                   10                  15      


Lys Gly Gln Glu Phe Ala Pro Ser His Gln Gln Val Tyr Ala Pro Leu 
            20                  25                  30          


Arg Ala Asp Gly Asp Lys Pro Arg Ala His Leu Thr Val Val Arg Gln 
        35                  40                  45              


Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His Trp Glu 
    50                  55                  60                  


His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr Asn 
65                  70                  75                  80  


Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln 
                85                  90                  95      


Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln Ala 
            100                 105                 110         


Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys Val 
        115                 120                 125             


Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys Ser 
    130                 135                 140                 


Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala 
145                 150                 155                 160 


Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser Asp 
                165                 170                 175     


Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala 
            180                 185                 190         


Phe Leu Leu 
        195 


<210>  60
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  60

His Arg Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp 
1               5                   10                  15      


Phe Val Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser 
            20                  25                  30          


Leu Ser Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe 
        35                  40                  45              


Val Lys Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser 
    50                  55                  60                  


Phe Glu Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val 
65                  70                  75                  80  


Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu 
                85                  90                  95      


Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly 
            100                 105                 110         


Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln 
        115                 120                 125             


Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile 
    130                 135                 140                 


Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu 
145                 150                 155                 160 


Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser 
                165                 170                 175     


Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe 
            180                 185                 190         


Val Asn Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr 
        195                 200                 205             


Ser Phe Gly Leu Leu Lys Leu 
    210                 215 


<210>  61
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  61

Gln Arg Thr Asp Ser Ile Pro Asn Ser Pro Asp Asn Val Pro Leu Lys 
1               5                   10                  15      


Gly Gly Asn Cys Ser Glu Asp Leu Leu Cys Ile Leu Lys Arg Ala Pro 
            20                  25                  30          


Phe Lys Lys Ser Trp Ala Tyr Leu Gln Val Ala Lys His Leu Asn Lys 
        35                  40                  45              


Thr Lys Leu Ser Trp Asn Lys Asp Gly Ile Leu His Gly Val Arg Tyr 
    50                  55                  60                  


Gln Asp Gly Asn Leu Val Ile Gln Phe Pro Gly Leu Tyr Phe Ile Ile 
65                  70                  75                  80  


Cys Gln Leu Gln Phe Leu Val Gln Cys Pro Asn Asn Ser Val Asp Leu 
                85                  90                  95      


Lys Leu Glu Leu Leu Ile Asn Lys His Ile Lys Lys Gln Ala Leu Val 
            100                 105                 110         


Thr Val Cys Glu Ser Gly Met Gln Thr Lys His Val Tyr Gln Asn Leu 
        115                 120                 125             


Ser Gln Phe Leu Leu Asp Tyr Leu Gln Val Asn Thr Thr Ile Ser Val 
    130                 135                 140                 


Asn Val Asp Thr Phe Gln Tyr Ile Asp Thr Ser Thr Phe Pro Leu Glu 
145                 150                 155                 160 


Asn Val Leu Ser Ile Phe Leu Tyr Ser Asn Ser Asp 
                165                 170         


<210>  62
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  62

Thr Asn Glu Leu Lys Gln Met Gln Asp Lys Tyr Ser Lys Ser Gly Ile 
1               5                   10                  15      


Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr Trp Asp Pro Asn Asp Glu 
            20                  25                  30          


Glu Ser Met Asn Ser Pro Cys Trp Gln Val Lys Trp Gln Leu Arg Gln 
        35                  40                  45              


Leu Val Arg Lys Met Ile Leu Arg Thr Ser Glu Glu Thr Ile Ser Thr 
    50                  55                  60                  


Val Gln Glu Lys Gln Gln Asn Ile Ser Pro Leu Val Arg Glu Arg Gly 
65                  70                  75                  80  


Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn 
                85                  90                  95      


Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys 
            100                 105                 110         


Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn 
        115                 120                 125             


Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr 
    130                 135                 140                 


Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu 
145                 150                 155                 160 


Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr 
                165                 170                 175     


Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys 
            180                 185                 190         


Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly 
        195                 200                 205             


Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn 
    210                 215                 220                 


Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe 
225                 230                 235                 240 


Leu Val Gly 
            


<210>  63
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  63

Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu Pro Leu Glu Ser Leu Gly 
1               5                   10                  15      


Trp Asp Val Ala Glu Leu Gln Leu Asn His Thr Gly Pro Gln Gln Asp 
            20                  25                  30          


Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala Leu Gly Arg Ser Phe Leu 
        35                  40                  45              


His Gly Pro Glu Leu Asp Lys Gly Gln Leu Arg Ile His Arg Asp Gly 
    50                  55                  60                  


Ile Tyr Met Val His Ile Gln Val Thr Leu Ala Ile Cys Ser Ser Thr 
65                  70                  75                  80  


Thr Ala Ser Arg His His Pro Thr Thr Leu Ala Val Gly Ile Cys Ser 
                85                  90                  95      


Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg Leu Ser Phe His Gln Gly 
            100                 105                 110         


Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro Leu Ala Arg Gly Asp Thr 
        115                 120                 125             


Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu Pro Ser Arg Asn Thr Asp 
    130                 135                 140                 


Glu Thr Phe Phe Gly Val Gln Trp Val Arg Pro 
145                 150                 155 


<210>  64
<211>  0
<212>  PRT
<213>  Homo sapiens

<400>  64
000
<210>  65
<211>  0
<212>  PRT
<213>  Homo sapiens

<400>  65
000
<210>  66
<211>  0
<212>  PRT
<213>  Homo sapiens

<400>  66
000
<210>  67
<211>  0
<212>  PRT
<213>  Homo sapiens

<400>  67
000
<210>  68
<211>  0
<212>  PRT
<213>  Homo sapiens

<400>  68
000
<210>  69
<211>  0
<212>  PRT
<213>  Homo sapiens

<400>  69
000
<210>  70
<211>  217
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  70

Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Ser Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys 
                85                  90                  95      


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Asn Ala Thr Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Arg Leu Thr Val Asp Lys Ser Ser Trp Gln Glu Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    210                 215         


<210>  71
<211>  217
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  71

Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Ser Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys 
                85                  90                  95      


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Asn Ala Thr Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Arg Leu Thr Val Asp Lys Ser Ser Trp Gln Glu Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    210                 215         


<210>  72
<211>  217
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  72

Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Gln Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Thr Pro His 
65                  70                  75                  80  


Ser Asp Trp Leu Ser Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys 
                85                  90                  95      


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Asn Ala Thr Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Arg Leu Thr Val Asp Lys Ser Ser Trp Gln Glu Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Leu His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    210                 215         


<210>  73
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  73

Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10      


<210>  74
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  74

Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10      


<210>  75
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  75

Ser Lys Tyr Gly Pro Pro 
1               5       


<210>  76
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  76

Ile Glu Gly Arg Met Asp 
1               5       


<210>  77
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  77

Gly Gly Gly Val Pro Arg Asp Cys Gly 
1               5                   


<210>  78
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  78

Ile Glu Gly Arg Met Asp Gly Gly Gly Gly Ala Gly Gly Gly Gly 
1               5                   10                  15  


