
                                SEQUENCE LISTING

<110> Davidson, Beverley L.
      Yrigollen, Carolyn M.
      Monteys, Alejandro
      Simpson, Bryan

<120> Compositions and Methods for Treating
  Fragile X Syndrome and Related Syndromes
  

<130> 3460-P06256WO00

<150> 62/237,771          
<151> 2015-10-06  

<160> 24

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 704
<212> DNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (466)...(468)
<223> nnn = absent or cgg repeat(s)

<400> 1
atgcatttga tttcccacgc cactgagtgc acctctgcag aaatgggcgt tctggccctc 60
gcgaggcagt gcgacctgtc accgcccttc agccttcccg ccctccacca agcccgcgca 120
cgcccggccc gcgcgtctgt ctttcgaccc ggcaccccgg ccggttccca gcagcgcgca 180
tgcgcgcgct cccaggccac ttgaagagag agggcggggc cgaggggctg agcccgcggg 240
gggagggaac agcgttgatc acgtgacgtg gtttcagtgt ttacacccgc agcgggccgg 300
gggttcggcc tcagtcaggc gctcagctcc gtttcggttt cacttccggt ggagggccgc 360
ctctgagcgg gcggcgggcc gacggcgagc gcgggcggcg gcggtgacgg aggcgccgct 420
gccagggggc gtgcggcagc gcggcggcgg cggcggcggc ggcggnnncg gcggcggcgg 480
cggcggcggc ggctgggcct cgagcgcccg cagcccacct ctcgggggcg ggctcccggc 540
gctagcaggg ctgaagagaa gatggaggag ctggtggtgg aagtgcgggg ctccaatggc 600
gctttctaca aggtacttgg ctctagggca ggccccatct tcgcccttcc ttccctccct 660
tttcttcttg gtgtcggcgg gaggcaggcc cggggccctc ttcc                  704

<210> 2
<211> 236
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> (141)...(143)
<223> nnn = absent or cgg repeat(s)

<400> 2
gctccgtttc ggtttcactt ccggtggagg gccgcctctg agcgggcggc gggccgacgg 60
cgagcgcggg cggcggcggt gacggaggcg ccgctgccag ggggcgtgcg gcagcgcggc 120
ggcggcggcg gcggcggcgg nnncggcggc ggcggcggcg gcggcggctg ggcctcgagc 180
gcccgcagcc cacctctcgg gggcgggctc ccggcgctag cagggctgaa gagaag     236

<210> 3
<211> 223
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> (121)...(123)
<223> nnn = absent or cgg repeat(s)

<400> 3
cggtggaggg ccgcctctga gcgggcggcg ggccgacggc gagcgcgggc ggcggcggtg 60
acggaggcgc cgctgccagg gggcgtgcgg cagcgcggcg gcggcggcgg cggcggcggc 120
nnncggcggc ggcggcggcg gcggcggcgg cggcggcggc ggcggcggct gggcctcgag 180
cgcccgcagc ccacctctcg ggggcgggct cccggcgcta gca                   223

<210> 4
<211> 240
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 4
cggtggaggg ccgcctctga gcgggcggcg ggccgacggc gagcgcgggc ggcggcggtg 60
acggaggcgc cgctgccagg gggcgtgcgg cagcgcggcg gcggcggcgg cggcggcggc 120
ggaggcggcg gcggcggcgg cggcggcggc ggaggcggcg gcggcggcgg cggcggcggc 180
ggcggctggg cctcgagcgc ccgcagccca cctctcgggg gcgggctccc ggcgctagca 240


<210> 5
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Target Sequence

<400> 5
ccagggggcg tgcggcagcg                                             20

<210> 6
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Target Sequence

<400> 6
gcagcgcggc ggcggcgg                                               18

<210> 7
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Target Sequence

<400> 7
aggtgggctg cgggcgctcg                                             20

<210> 8
<211> 225
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> (158)...(160)
<223> nnn = cgg repeat(s)

<400> 8
gctcagctcc gtttcggttt cacttccggt ggagggccgc ctctgagcgg gcggcgggcc 60
gacggcgagc gcgggcggcg gcggtgacgg aggcgccgct gccagggggc gtgcggcagc 120
gcggcggcgg cggcggcggc ggcggcggag gcggcggnnn cggcggcggc ggcggctggg 180
cctcgagcgc ccgcagccca cctctcgggg gcgggctccc ggcgc                 225

<210> 9
<211> 224
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> (122)...(124)
<223> nnn = cgg repeats

<400> 9
gctcagctcc gtttcggttt cacttccggt ggagggccgc ctctgagcgg gcggcgggcc 60
gacggcgagc gcgggcggcg gcggtgacgg aggcgccgct gccagggggc gtgcggcagc 120
gnnnctgggc ctcgagcgcc cgcagcccac ctctcggggg cgggctcccg gcgctagcag 180
ggctgaagag aagatggagg agctggtggt ggaagtgcgg ggct                  224

<210> 10
<211> 80
<212> RNA
<213> Artificial Sequence

<220> 
<223> scaffold gRNA

<400> 10
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu 60
ggcaccgagu cggugcuuuu                                             80

<210> 11
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> forward primer

<400> 11
gctcagctcc gtttcggttt cacttccggt                                  30

<210> 12
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> reverse primer

<400> 12
agccccgcac ttccaccacc agctcctcca                                  30

<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> target sequence

<400> 13
tgacggaggc gccgctgcca                                             20

<210> 14
<211> 18
<212> RNA
<213> Artificial Sequence

<220> 
<223> gRNA sequence

<400> 14
gcagcgcggc ggcggcgg                                               18

<210> 15
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> gRNA sequence

<400> 15
aggugggcug cgggcgcucg                                             20

<210> 16
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> gRNA sequence

<400> 16
ccagggggcg ugcggcagcg                                             20

<210> 17
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Target sequence

<400> 17
ccgccgccgc cgccgccgcc g                                           21

<210> 18
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Target sequence

<400> 18
ggcggcggcg gcggcggcgg                                             20

<210> 19
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Target sequence

<400> 19
ggcagcgcgg cggcggcggc gg                                          22

<210> 20
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Target sequence

<400> 20
ggcccagccg ccgccgccg                                              19

<210> 21
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> gRNA sequence

<400> 21
ccgccgccgc cgccgccgcc g                                           21

<210> 22
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> gRNA sequence

<400> 22
ggcggcggcg gcggcggcgg                                             20

<210> 23
<211> 22
<212> RNA
<213> Artificial Sequence

<220> 
<223> gRNA sequence

<400> 23
ggcagcgcgg cggcggcggc gg                                          22

<210> 24
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> gRNA sequence

<400> 24
ggcccagccg ccgccgccg                                              19
