                         SEQUENCE LISTING

<110>  APELLIS PHARMACEUTICALS, INC.
 
<120>  DOSING REGIMENS

<130>  2008575-0217

<140>  PCT/US2016/056144
<141>  2016-10-07

<150>  62/238,529
<151>  2015-10-07

<150>  62/372,259
<151>  2016-08-08

<160>  76    

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<400>  1

Ile Cys Val Val Gln Asp Trp Gly His His Arg Cys Thr 
1               5                   10              


<210>  2
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(19)
<223>  Any independently selected amino acid or amino acid analog

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  This region may encompass 2 to 19 residues, wherein some residues
       may be absent

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  Trp or an analog of Trp

<220>
<221>  MOD_RES
<222>  (24)..(42)
<223>  Any independently selected amino acid or amino acid analog

<220>
<221>  misc_feature
<222>  (24)..(42)
<223>  This region may encompass 2 to 19 residues, wherein some residues
       may be absent

<400>  2

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Gln Asp Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40          


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Trp or an analog of Trp

<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  see specification as filed for detailed description of 
       substitutions and preferred embodiments

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Trp or an analog of Trp

<400>  3

Xaa Gln Asp Xaa Gly 
1               5   


<210>  4
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Trp or an analog of Trp

<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  see specification as filed for detailed description of 
       substitutions and preferred embodiments

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Trp or an analog of Trp

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  His, Ala, analogs of Ala, Phe or Trp

<400>  4

Xaa Gln Asp Xaa Gly Xaa 
1               5       


<210>  5
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(3)
<223>  Any independently selected amino acid or amino acid analog

<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  see specification as filed for detailed description of 
       substitutions and preferred embodiments

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Trp or analog of Trp

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Trp or analog of Trp

<220>
<221>  MOD_RES
<222>  (9)..(13)
<223>  Any independently selected amino acid or amino acid analog

<400>  5

Xaa Xaa Xaa Xaa Gln Asp Xaa Gly Xaa Xaa Xaa Xaa Xaa 
1               5                   10              


<210>  6
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  Ile, Val, Leu, B1-Ile, B1-Val, B1-Leu or a dipeptide comprising 
       Gly-Ile or B1-Gly-Ile, wherein B1 represents a first blocking 
       moiety

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  This region may encompass 1 to 2 residues, wherein some positions
       may be absent

<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  see specification as filed for detailed description of 
       substitutions and preferred embodiments

<220>
<221>  misc_feature
<222>  (3)..(13)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Independently selected from Trp or analogs of Trp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Independently selected from Trp or analogs of Trp

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  His, Ala or an analog of Ala, Phe, Trp or an analog of Trp

<220>
<221>  MOD_RES
<222>  (14)..(16)
<223>  L-Thr, D-Thr, Ile, Val, Gly, a dipeptide selected from Thr-Ala or
       Thr-Asn, or a tripeptide comprising Thr-Ala-Asn, wherein a c-term
       -OH of any of the L-Thr, D-Thr, Ile, Val, Gly, Ala or Asn is 
       optionally replaced by a second blocking moiety

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  This region may encompass 1 to 3 residues, wherein some positions
       may be absent

<400>  6

Xaa Xaa Cys Val Xaa Gln Asp Xaa Gly Xaa His Arg Cys Xaa Xaa Xaa 
1               5                   10                  15      


<210>  7
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  Ile, Val, Leu, Ac-Ile, Ac-Val, Ac-Leu or a dipeptide comprising 
       Gly-Ile or Ac-Gly-Ile

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  This region may encompass 1 to 2 residues, wherein some positions
       may be absent

<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  see specification as filed for detailed description of 
       substitutions and preferred embodiments

<220>
<221>  misc_feature
<222>  (3)..(13)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Independently selected from Trp or analogs of Trp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Independently selected from Trp or analogs of Trp

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  His, Ala or an analog of Ala, Phe, Trp or an analog of Trp

<220>
<221>  MOD_RES
<222>  (14)..(16)
<223>  L-Thr, D-Thr, Ile, Val, Gly, a dipeptide selected from Thr-Ala or
       Thr-Asn, or a tripeptide comprising Thr-Ala-Asn, wherein a c-term
       -OH of any of L-Thr, D-Thr, Ile, Val, Gly, Ala, or Asn is 
       optionally replaced by -NH2

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  This region may encompass 1 to 3 residues, wherein some positions
       may be absent

<400>  7

Xaa Xaa Cys Val Xaa Gln Asp Xaa Gly Xaa His Arg Cys Xaa Xaa Xaa 
1               5                   10                  15      


<210>  8
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term H

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  8

Ile Cys Val Val Gln Asp Trp Gly His His Arg Cys Thr 
1               5                   10              


<210>  9
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  9

Ile Cys Val Val Gln Asp Trp Gly His His Arg Cys Thr 
1               5                   10              


<210>  10
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  10

Ile Cys Val Tyr Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  11
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term COOH

<400>  11

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  12
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  C-term CONH2

<400>  12

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  13
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  d-Thr

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term COOH

<400>  13

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  14
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  2-Nal

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  14

Ile Cys Val Ala Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  15
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  2-Nal

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term COOH

<400>  15

Ile Cys Val Ala Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  16
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  1-Nal

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term COOH

<400>  16

Ile Cys Val Ala Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  17
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  2-Igl

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  17

Ile Cys Val Gly Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  18
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  2-Igl

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term COOH

<400>  18

Ile Cys Val Gly Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  19
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Dht

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term COOH

<400>  19

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  20
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Bpa

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term COOH

<400>  20

Ile Cys Val Phe Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  21
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Bpa

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  21

Ile Cys Val Phe Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  22
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Bta

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term COOH

<400>  22

Ile Cys Val Xaa Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  23
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Bta

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  23

Ile Cys Val Xaa Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  24
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  2-Abu

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  24

Ile Cys Val Trp Gln Asp Trp Gly Xaa His Arg Cys Thr 
1               5                   10              


<210>  25
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term H

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  C-term COOH

<400>  25

Gly Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Ala Asn 
1               5                   10                  15      


<210>  26
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  5f-Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  26

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  27
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  5-methyl-Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  27

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  28
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  1-methyl-Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  28

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  29
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  5f-Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  29

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  30
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  5f-Trp

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  5f-Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  30

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  31
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  5-methyl-Trp

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  5f-Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  31

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  32
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  1-methyl-Trp

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  5f-Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  32

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  33
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term H

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  6f-Trp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  6f-Trp

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  C-term COOH

<400>  33

Gly Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Asn 
1               5                   10                  15  


<210>  34
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  1-formyl-Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  34

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  35
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  1-methoxy-Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  35

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  36
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term H

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  5f-Trp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  5f-Trp

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  C-term COOH

<400>  36

Gly Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Asn 
1               5                   10                  15  


<210>  37
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<400>  37

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  38
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Maleimide-(CH2)5-C(=O)

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term NH2

<400>  38

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  39
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term (C=O)-(CH2)5-maleimide

<400>  39

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  40
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Maleimide-(CH2)2-C(=O)-NH-CH2CH2OCH2CH2O CH2CH2C(=O)

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term NH2

<400>  40

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  41
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Maleimide-(CH2)2-C(=O)-NH-CH2CH2OCH2CH2C(=O)

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term NH2

<400>  41

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  42
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Maleimide-(CH2)3-C(=O)-NH-CH2CH2OCH2CH2 OCH2C(=O)

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term NH2

<400>  42

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  43
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Maleimide-(CH2)5-C(=O)-NH-CH2CH2OCH2CH2 OCH2C(=O)

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term NH2

<400>  43

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  44
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Maleimide-(CH2)4-C(=O)-NH-CH2CH2OCH2CH2 OCH2CH2C(=O)

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term NH2

<400>  44

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  45
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Maleimide-(CH2)2-C(=O)-NH-CH2CH2OCH2CH2 OCH2CH2C(=O)

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term NH2

<400>  45

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  46
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Maleimide-(CH2)5-C(=O)-NH-CH2CH2OCH2CH2 OCH2C(=O)

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term NH2

<400>  46

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  47
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C-term NH2

<400>  47

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210>  48
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  C-term NH2

<400>  48

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Gly Gly Gly 
1               5                   10                  15      


Gly Gly Lys 
            


<210>  49
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term NH2(CH2)5C(=O)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term NH2

<400>  49

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  50
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term NH2(CH2CH2O)2CH2C(=O)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term NH2

<400>  50

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  51
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  NH-CH2CH2OCH2CH2OCH2-C(=O)-Lys

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C-term NH2

<400>  51

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210>  52
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Lys-(C(=O)-(CH2)5-Mal)

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C-term NH2

<400>  52

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210>  53
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Lys-(C(=O)-(CH2)5-Mal)

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  C-term NH2

<400>  53

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Gly Gly Gly 
1               5                   10                  15      


Gly Gly Lys 
            


<210>  54
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Mal-(CH2)5-(C(=O)-NH(CH2)5C(=O)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term NH2

<400>  54

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  55
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Mal-(CH2)5-(C(=O)NH(CH2CH2O)2CH2C(=O)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term NH2

<400>  55

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  56
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  NH-CH2CH2OCH2CH2OCH2-C(=O)-Lys-(C(=O)-(CH2)5-Mal)

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C-term NH2

<400>  56

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210>  57
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Lys-C(=O)-CH2(OCH2CH2)2NH(C(=O)-(CH2)5-Mal)

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C-term NH2

<400>  57

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210>  58
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term (CH2CH2O)nC(=O)

<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  see specification as filed for detailed description of 
       substitutions and preferred embodiments

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term NH2

<400>  58

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  59
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  see specification as filed for detailed description of 
       substitutions and preferred embodiments

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  NH-CH2CH2OCH2CH2OCH2-C(=O)-Lys-C(=O)-(CH2CH2O)n

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C-term NH2

<400>  59

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210>  60
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  see specification as filed for detailed description of 
       substitutions and preferred embodiments

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Lys-C(=O)-(CH2CH2O)n

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C-term NH2

<400>  60

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210>  61
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  see specification as filed for detailed description of 
       substitutions and preferred embodiments

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Lys-C(=O)-(CH2CH2O)n

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  C-term NH2

<400>  61

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Gly Gly Gly 
1               5                   10                  15      


Gly Gly Lys 
            


<210>  62
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (CH2CH2O)nC(=O)Lys

<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  see specification as filed for detailed description of 
       substitutions and preferred embodiments

<220>
<221>  misc_feature
<222>  (8)..(18)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term NH2

<400>  62

Lys Gly Gly Gly Gly Gly Ile Cys Val Trp Gln Asp Trp Gly Ala His 
1               5                   10                  15      


Arg Cys Thr 
            


<210>  63
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (CH2CH2O)nC(=O)Lys

<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  see specification as filed for detailed description of 
       substitutions and preferred embodiments

<220>
<221>  misc_feature
<222>  (3)..(13)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C-term NH2

<400>  63

Lys Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10                  


<210>  64
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  see specification as filed for detailed description of 
       substitutions and preferred embodiments

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  NH-CH2CH2OCH2CH2OCH2-C(=O)-Lys-(C(=O)-(CH2CH2O)n-R)

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C-term NH2

<400>  64

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210>  65
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  see specification as filed for detailed description of 
       substitutions and preferred embodiments

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  NH-CH2CH2OCH2CH2OCH2-C(=O)-Lys-(C(=O)-(CH2)m- (CH2CH2O)n-R)

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C-term NH2

<400>  65

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210>  66
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  see specification as filed for detailed description of 
       substitutions and preferred embodiments

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  NH-CH2CH2OCH2CH2OCH2-C(=O)-Lys-(C(=O)-(CH2)m-C(=O)- (CH2CH2O)n-R)

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C-term NH2

<400>  66

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210>  67
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  NH-CH2CH2OCH2CH2OCH2-C(=O)-Lys-(C(=O)-(CH2)m-C(=O) 
       -(CH2)j(CH2CH2O)n-R)

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C-term NH2

<400>  67

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210>  68
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  see specification as filed for detailed description of 
       substitutions and preferred embodiments

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  AEEAc-Lys-(C(=O)-(CH2)5-Mal)

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C-term NH2

<400>  68

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210>  69
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 6xHis tag

<400>  69

His His His His His His 
1               5       


<210>  70
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  see specification as filed for detailed description of 
       substitutions and preferred embodiments

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Trp or an analog of Trp

<400>  70

Gln Asp Xaa Gly 
1               


<210>  71
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Any amino acid; comprises a blocking moiety

<220>
<221>  MOD_RES
<222>  (2)..(4)
<223>  Any independently selected amino acid or amino acid analog

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Trp or analog of Trp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Trp or analog of Trp

<220>
<221>  MOD_RES
<222>  (10)..(14)
<223>  Any independently selected amino acid or amino acid analog

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Any amino acid; comprises a blocking moiety

<400>  71

Xaa Xaa Xaa Xaa Xaa Gln Asp Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15  


<210>  72
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Any amino acid; comprises a blocking moiety

<220>
<221>  MOD_RES
<222>  (2)..(3)
<223>  Ile, Val, Leu, B1-Ile, B1-Val, B1-Leu or a dipeptide comprising 
       Gly-Ile or B1-Gly-Ile, wherein B1 represents a first blocking 
       moiety

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  This region may encompass 1 to 2 residues, wherein some positions
       may be absent

<220>
<221>  misc_feature
<222>  (4)..(14)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Independently selected from Trp or analogs of Trp

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Independently selected from Trp or analogs of Trp

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  His, Ala or an analog of Ala, Phe, Trp or an analog of Trp

<220>
<221>  MOD_RES
<222>  (15)..(17)
<223>  L-Thr, D-Thr, Ile, Val, Gly, a dipeptide selected from Thr-Ala or
       Thr-Asn, or a tripeptide comprising Thr-Ala-Asn, wherein a c-term
       -OH of any of the L-Thr, D-Thr, Ile, Val, Gly, Ala or Asn is 
       optionally replaced by a second blocking moiety

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  This region may encompass 1 to 3 residues, wherein some positions
       may be absent

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Any amino acid; comprises a blocking moiety

<400>  72

Xaa Xaa Xaa Cys Val Xaa Gln Asp Xaa Gly Xaa His Arg Cys Xaa Xaa 
1               5                   10                  15      


Xaa Xaa 
        


<210>  73
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Any amino acid; comprises a blocking moiety

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ile or Gly

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Ile or Cys

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Val or Cys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Val, Tyr, Trp, 2-Nal, 1-Nal, 2-Igl, Dht, Bpa, Bta, 5f-Trp, 
       5-methyl-Trp, 1-methyl-Trp, 1-formyl-Trp or 1-methyoxy-Trp

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Gln, Trp, 6f-Trp or 5f-Trp

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Asp or Gln

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Trp, Asp or 5f-Trp

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Gly, Trp, 6f-Trp or 5f-Trp

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  His, Ala, 2-Abu or Gly

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  His or Ala

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Arg or His

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  Cys or Arg

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Thr, d-Thr or Cys

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Any amino acid; comprises a blocking moiety

<400>  73

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15  


<210>  74
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Any amino acid; comprises a blocking moiety

<220>
<221>  misc_feature
<222>  (3)..(13)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Trp(Me)

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  mGly

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  mIle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Any amino acid; comprises a blocking moiety

<400>  74

Xaa Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Ile Xaa 
1               5                   10                  15  


<210>  75
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Any amino acid; comprises a blocking moiety

<220>
<221>  misc_feature
<222>  (3)..(13)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Trp(Me)

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  mGly

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  mIle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Any amino acid; comprises a blocking moiety

<400>  75

Xaa Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Ile Xaa 
1               5                   10                  15  


<210>  76
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<400>  76

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


