                         SEQUENCE LISTING

<110>  Technische Universitt Mnchen
 
<120>  Mutant  beta-glucosidase variants with increased thermostability

<130>  MTU103WO

<160>  52    

<170>  PatentIn version 3.5

<210>  1
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  VARIANT
<222>  (40)..(40)
<223>  Xaa is selected from Glu, Pro, Thr, Met, Ala, Ser and Gly

<220>
<221>  VARIANT
<222>  (111)..(111)
<223>  Xaa is selected from Val, Lys, Arg and His

<220>
<221>  VARIANT
<222>  (293)..(293)
<223>  Xaa is selected from Val, Ile, Leu, Met, Pro, Thr and Ala

<220>
<221>  VARIANT
<222>  (423)..(423)
<223>  Xaa is selected from Thr, Glu, Asp, Asn, Gln, Met and Pro

<220>
<221>  VARIANT
<222>  (441)..(441)
<223>  Xaa is selected from Leu, Arg, Lys and His

<400>  1

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Xaa Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Xaa Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Xaa Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Xaa Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Xaa Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  2
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  Variant
<222>  (111)..(111)
<223>  Xaa is selected from Val, Lys, Arg and His

<220>
<221>  Variant
<222>  (293)..(293)
<223>  Xaa is selected from Val, Ile, Leu, Met, Pro, Thr and Ala

<220>
<221>  Variant
<222>  (423)..(423)
<223>  Xaa is selected from Thr, Glu, Asp, Asn, Gln, Met and Pro

<220>
<221>  Variant
<222>  (441)..(441)
<223>  Xaa is selected from Leu, Arg, Lys and His

<400>  2

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Pro Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Xaa Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Xaa Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Xaa Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Xaa Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  3
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  Variant
<222>  (40)..(40)
<223>  Xaa is selected from Glu, Pro, Thr, Met, Ala, Ser and Gly

<220>
<221>  Variant
<222>  (293)..(293)
<223>  Xaa is selected from Val, Ile, Leu, Met, Pro, Thr and Ala

<220>
<221>  Variant
<222>  (423)..(423)
<223>  Xaa is selected from Thr, Glu, Asp, Asn, Gln, Met and Pro

<220>
<221>  Variant
<222>  (441)..(441)
<223>  Xaa is selected from Leu, Arg, Lys and His

<400>  3

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Xaa Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Lys Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Xaa Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Xaa Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Xaa Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  4
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  Variant
<222>  (40)..(40)
<223>  Xaa is selected from Glu, Pro, Thr, Met, Ala, Ser and Gly

<220>
<221>  Variant
<222>  (111)..(111)
<223>  Xaa is selected from Val, Lys, Arg and His

<220>
<221>  Variant
<222>  (423)..(423)
<223>  Xaa is selected from Thr, Glu, Asp, Asn, Gln, Met and Pro

<220>
<221>  Variant
<222>  (441)..(441)
<223>  Xaa is selected from Leu, Arg, Lys and His

<400>  4

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Xaa Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Xaa Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Ile Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Xaa Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Xaa Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  5
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  Variant
<222>  (40)..(40)
<223>  Xaa is selected from Glu, Pro, Thr, Met, Ala, Ser and Gly

<220>
<221>  Variant
<222>  (111)..(111)
<223>  Xaa is selected from Val, Lys, Arg and His

<220>
<221>  Variant
<222>  (293)..(293)
<223>  Xaa is selected from Val, Ile, Leu, Met, Pro, Thr and Ala

<220>
<221>  Variant
<222>  (441)..(441)
<223>  Xaa is selected from Leu, Arg, Lys and His

<400>  5

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Xaa Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Xaa Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Xaa Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Glu Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Xaa Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  6
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  Variant
<222>  (40)..(40)
<223>  Xaa is selected from Glu, Pro, Thr, Met, Ala, Ser and Gly

<220>
<221>  Variant
<222>  (111)..(111)
<223>  X is selected from V, K, R and H

<220>
<221>  Variant
<222>  (293)..(293)
<223>  Xaa is selected from Val, Ile, Leu, Met, Pro, Thr and Ala

<220>
<221>  Variant
<222>  (423)..(423)
<223>  Xaa is selected from Thr, Glu, Asp, Asn, Gln, Met and Pro

<400>  6

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Xaa Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Xaa Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Xaa Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Xaa Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Arg Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  7
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  7

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Pro Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Val Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  8
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  8

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Lys Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  9
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  9

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Val Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Ile Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  10
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  10

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Val Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Glu Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  11
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  11

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Val Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Arg Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  12
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  12

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Pro Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Lys Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  13
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  13

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Pro Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Val Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Ile Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  14
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  14

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Pro Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Val Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Glu Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  15
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  15

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Pro Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Val Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Arg Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  16
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  16

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Lys Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Ile Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  17
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  17

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Lys Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Glu Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  18
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  18

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Lys Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Arg Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  19
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  19

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Val Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Ile Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Glu Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  20
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  20

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Val Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Ile Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Arg Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  21
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Poylpeptide

<400>  21

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Val Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Glu Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Arg Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  22
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  22

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Pro Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Lys Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Ile Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  23
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  23

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Pro Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Lys Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Glu Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  24
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  24

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Pro Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Lys Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Arg Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  25
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  25

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Pro Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Val Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Ile Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Glu Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  26
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  26

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Pro Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Val Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Ile Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Arg Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  27
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  27

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Pro Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Val Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Glu Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Arg Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  28
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  28

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Lys Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Ile Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Glu Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  29
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Poylpeptide

<400>  29

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Lys Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Ile Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Arg Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  30
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  30

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Lys Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Glu Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Arg Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  31
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  31

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Val Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Ile Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Glu Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Arg Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  32
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  32

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Pro Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Lys Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Ile Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Glu Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  33
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  33

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Pro Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Lys Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Ile Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Arg Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  34
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  34

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Pro Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Lys Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Glu Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Arg Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  35
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  35

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Pro Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Val Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Ile Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Glu Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Arg Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  36
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  36

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Lys Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Ile Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Glu Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Arg Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  37
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  37

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Pro Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Lys Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Ile Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Glu Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Arg Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  38
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  38
atggccaagt ttcctcgcga ctttgtatgg ggtacagcca catcgagtta tcagattgaa       60

ggcgcggtga atgaagatgg tcgtacaccg tctatctggg acaccttttc gaaaaccgag      120

ggcaaaacct ataaaggcca tacgggtgat gttgcctgtg atcactatca ccgctataag      180

gaagatgtgg aaattctgaa agaaattgga gtcaaagcct accggtttag cattgcatgg      240

ccacgtatct ttcctgagga aggcaaatac aacccgaaag gtatggattt ctacaagaaa      300

ctcattgacg aactgcaaaa gcgcgatatt gttcccgcag cgaccattta tcactgggat      360

ctgccacaat gggcctatga caaaggcggt ggctggctga accgtgagtc catcaaatgg      420

tatgtggagt acgcgaccaa attgtttgaa gaactgggtg atgcgatccc gctgtggatt      480

acccataatg agccatggtg ctcttctatc ctcagttatg gtatcggcga acatgcacct      540

ggtcataaga actatcgcga agcgcttatt gctgcgcatc acatcctgct ctcacatggc      600

gaagcggtca aagcgtttcg cgaaatgaac attaagggga gcaaaatcgg cattacgctt      660

aacttgactc cggcgtatcc agcaagtgag aaagaagaag ataaactggc tgcacagtat      720

gcagatggct ttgccaatcg ctggttcctt gacccgatct tcaagggtaa ctatccggag      780

gacatgatgg aattgtacag caaaattatt ggggaattcg atttcattaa ggaaggcgat      840

ctggagacta tcagcgtccc gattgacttc ttaggcgtca attactacac tcggagcatt      900

gttaaatacg atgaagattc catgctgaaa gcagagaacg taccgggacc gggtaaacgt      960

accgaaatgg ggtgggaaat ctcgcccgag tcactgtacg acttactgaa acgcttagac     1020

cgtgagtata cgaaactgcc gatgtatatc accgaaaatg gagctgcgtt taaagatgaa     1080

gtaacggaag atggtcgtgt tcacgacgat gaacgcatcg aatacatcaa agagcacctg     1140

aaagctgccg ctaaatttat cggggaaggc ggtaatctga aaggatactt tgtgtggtca     1200

ttaatggaca acttcgaatg ggcgcatggc tactccaaac gtttcggcat tgtgtatgtg     1260

gactatacga cccagaaacg cattctgaag gatagcgcct tgtggtacaa agaggtgatt     1320

ctggatgatg ggattgaaga t                                               1341


<210>  39
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  39
atggccaagt ttcctcgcga ctttgtatgg ggtacagcca catcgagtta tcagattgaa       60

ggcgcggtga atgaagatgg tcgtacaccg tctatctggg acaccttttc gaaaaccccg      120

ggcaaaacct ataaaggcca tacgggtgat gttgcctgtg atcactatca ccgctataag      180

gaagatgtgg aaattctgaa agaaattgga gtcaaagcct accggtttag cattgcatgg      240

ccacgtatct ttcctgagga aggcaaatac aacccgaaag gtatggattt ctacaagaaa      300

ctcattgacg aactgcaaaa gcgcgatatt gttcccgcag cgaccattta tcactgggat      360

ctgccacaat gggcctatga caaaggcggt ggctggctga accgtgagtc catcaaatgg      420

tatgtggagt acgcgaccaa attgtttgaa gaactgggtg atgcgatccc gctgtggatt      480

acccataatg agccatggtg ctcttctatc ctcagttatg gtatcggcga acatgcacct      540

ggtcataaga actatcgcga agcgcttatt gctgcgcatc acatcctgct ctcacatggc      600

gaagcggtca aagcgtttcg cgaaatgaac attaagggga gcaaaatcgg cattacgctt      660

aacttgactc cggcgtatcc agcaagtgag aaagaagaag ataaactggc tgcacagtat      720

gcagatggct ttgccaatcg ctggttcctt gacccgatct tcaagggtaa ctatccggag      780

gacatgatgg aattgtacag caaaattatt ggggaattcg atttcattaa ggaaggcgat      840

ctggagacta tcagcgtccc gattgacttc ttaggcgtca attactacac tcggagcatt      900

gttaaatacg atgaagattc catgctgaaa gcagagaacg taccgggacc gggtaaacgt      960

accgaaatgg ggtgggaaat ctcgcccgag tcactgtacg acttactgaa acgcttagac     1020

cgtgagtata cgaaactgcc gatgtatatc accgaaaatg gagctgcgtt taaagatgaa     1080

gtaacggaag atggtcgtgt tcacgacgat gaacgcatcg aatacatcaa agagcacctg     1140

aaagctgccg ctaaatttat cggggaaggc ggtaatctga aaggatactt tgtgtggtca     1200

ttaatggaca acttcgaatg ggcgcatggc tactccaaac gtttcggcat tgtgtatgtg     1260

gactatacga cccagaaacg cattctgaag gatagcgcct tgtggtacaa agaggtgatt     1320

ctggatgatg ggattgaaga t                                               1341


<210>  40
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  40
atggccaagt ttcctcgcga ctttgtatgg ggtacagcca catcgagtta tcagattgaa       60

ggcgcggtga atgaagatgg tcgtacaccg tctatctggg acaccttttc gaaaaccgag      120

ggcaaaacct ataaaggcca tacgggtgat gttgcctgtg atcactatca ccgctataag      180

gaagatgtgg aaattctgaa agaaattgga gtcaaagcct accggtttag cattgcatgg      240

ccacgtatct ttcctgagga aggcaaatac aacccgaaag gtatggattt ctacaagaaa      300

ctcattgacg aactgcaaaa gcgcgatatt aaacccgcag cgaccattta tcactgggat      360

ctgccacaat gggcctatga caaaggcggt ggctggctga accgtgagtc catcaaatgg      420

tatgtggagt acgcgaccaa attgtttgaa gaactgggtg atgcgatccc gctgtggatt      480

acccataatg agccatggtg ctcttctatc ctcagttatg gtatcggcga acatgcacct      540

ggtcataaga actatcgcga agcgcttatt gctgcgcatc acatcctgct ctcacatggc      600

gaagcggtca aagcgtttcg cgaaatgaac attaagggga gcaaaatcgg cattacgctt      660

aacttgactc cggcgtatcc agcaagtgag aaagaagaag ataaactggc tgcacagtat      720

gcagatggct ttgccaatcg ctggttcctt gacccgatct tcaagggtaa ctatccggag      780

gacatgatgg aattgtacag caaaattatt ggggaattcg atttcattaa ggaaggcgat      840

ctggagacta tcagcgtccc gattgacttc ttaggcgtca attactacac tcggagcatt      900

gttaaatacg atgaagattc catgctgaaa gcagagaacg taccgggacc gggtaaacgt      960

accgaaatgg ggtgggaaat ctcgcccgag tcactgtacg acttactgaa acgcttagac     1020

cgtgagtata cgaaactgcc gatgtatatc accgaaaatg gagctgcgtt taaagatgaa     1080

gtaacggaag atggtcgtgt tcacgacgat gaacgcatcg aatacatcaa agagcacctg     1140

aaagctgccg ctaaatttat cggggaaggc ggtaatctga aaggatactt tgtgtggtca     1200

ttaatggaca acttcgaatg ggcgcatggc tactccaaac gtttcggcat tgtgtatgtg     1260

gactatacga cccagaaacg cattctgaag gatagcgcct tgtggtacaa agaggtgatt     1320

ctggatgatg ggattgaaga t                                               1341


<210>  41
<211>  1341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  41

Ala Thr Gly Gly Cys Cys Ala Ala Gly Thr Thr Thr Cys Cys Thr Cys 
1               5                   10                  15      


Gly Cys Gly Ala Cys Thr Thr Thr Gly Thr Ala Thr Gly Gly Gly Gly 
            20                  25                  30          


Thr Ala Cys Ala Gly Cys Cys Ala Cys Ala Thr Cys Gly Ala Gly Thr 
        35                  40                  45              


Thr Ala Thr Cys Ala Gly Ala Thr Thr Gly Ala Ala Gly Gly Cys Gly 
    50                  55                  60                  


Cys Gly Gly Thr Gly Ala Ala Thr Gly Ala Ala Gly Ala Thr Gly Gly 
65                  70                  75                  80  


Thr Cys Gly Thr Ala Cys Ala Cys Cys Gly Thr Cys Thr Ala Thr Cys 
                85                  90                  95      


Thr Gly Gly Gly Ala Cys Ala Cys Cys Thr Thr Thr Thr Cys Gly Ala 
            100                 105                 110         


Ala Ala Ala Cys Cys Gly Ala Gly Gly Gly Cys Ala Ala Ala Ala Cys 
        115                 120                 125             


Cys Thr Ala Thr Ala Ala Ala Gly Gly Cys Cys Ala Thr Ala Cys Gly 
    130                 135                 140                 


Gly Gly Thr Gly Ala Thr Gly Thr Thr Gly Cys Cys Thr Gly Thr Gly 
145                 150                 155                 160 


Ala Thr Cys Ala Cys Thr Ala Thr Cys Ala Cys Cys Gly Cys Thr Ala 
                165                 170                 175     


Thr Ala Ala Gly Gly Ala Ala Gly Ala Thr Gly Thr Gly Gly Ala Ala 
            180                 185                 190         


Ala Thr Thr Cys Thr Gly Ala Ala Ala Gly Ala Ala Ala Thr Thr Gly 
        195                 200                 205             


Gly Ala Gly Thr Cys Ala Ala Ala Gly Cys Cys Thr Ala Cys Cys Gly 
    210                 215                 220                 


Gly Thr Thr Thr Ala Gly Cys Ala Thr Thr Gly Cys Ala Thr Gly Gly 
225                 230                 235                 240 


Cys Cys Ala Cys Gly Thr Ala Thr Cys Thr Thr Thr Cys Cys Thr Gly 
                245                 250                 255     


Ala Gly Gly Ala Ala Gly Gly Cys Ala Ala Ala Thr Ala Cys Ala Ala 
            260                 265                 270         


Cys Cys Cys Gly Ala Ala Ala Gly Gly Thr Ala Thr Gly Gly Ala Thr 
        275                 280                 285             


Thr Thr Cys Thr Ala Cys Ala Ala Gly Ala Ala Ala Cys Thr Cys Ala 
    290                 295                 300                 


Thr Thr Gly Ala Cys Gly Ala Ala Cys Thr Gly Cys Ala Ala Ala Ala 
305                 310                 315                 320 


Gly Cys Gly Cys Gly Ala Thr Ala Thr Thr Gly Thr Thr Cys Cys Cys 
                325                 330                 335     


Gly Cys Ala Gly Cys Gly Ala Cys Cys Ala Thr Thr Thr Ala Thr Cys 
            340                 345                 350         


Ala Cys Thr Gly Gly Gly Ala Thr Cys Thr Gly Cys Cys Ala Cys Ala 
        355                 360                 365             


Ala Thr Gly Gly Gly Cys Cys Thr Ala Thr Gly Ala Cys Ala Ala Ala 
    370                 375                 380                 


Gly Gly Cys Gly Gly Thr Gly Gly Cys Thr Gly Gly Cys Thr Gly Ala 
385                 390                 395                 400 


Ala Cys Cys Gly Thr Gly Ala Gly Thr Cys Cys Ala Thr Cys Ala Ala 
                405                 410                 415     


Ala Thr Gly Gly Thr Ala Thr Gly Thr Gly Gly Ala Gly Thr Ala Cys 
            420                 425                 430         


Gly Cys Gly Ala Cys Cys Ala Ala Ala Thr Thr Gly Thr Thr Thr Gly 
        435                 440                 445             


Ala Ala Gly Ala Ala Cys Thr Gly Gly Gly Thr Gly Ala Thr Gly Cys 
    450                 455                 460                 


Gly Ala Thr Cys Cys Cys Gly Cys Thr Gly Thr Gly Gly Ala Thr Thr 
465                 470                 475                 480 


Ala Cys Cys Cys Ala Thr Ala Ala Thr Gly Ala Gly Cys Cys Ala Thr 
                485                 490                 495     


Gly Gly Thr Gly Cys Thr Cys Thr Thr Cys Thr Ala Thr Cys Cys Thr 
            500                 505                 510         


Cys Ala Gly Thr Thr Ala Thr Gly Gly Thr Ala Thr Cys Gly Gly Cys 
        515                 520                 525             


Gly Ala Ala Cys Ala Thr Gly Cys Ala Cys Cys Thr Gly Gly Thr Cys 
    530                 535                 540                 


Ala Thr Ala Ala Gly Ala Ala Cys Thr Ala Thr Cys Gly Cys Gly Ala 
545                 550                 555                 560 


Ala Gly Cys Gly Cys Thr Thr Ala Thr Thr Gly Cys Thr Gly Cys Gly 
                565                 570                 575     


Cys Ala Thr Cys Ala Cys Ala Thr Cys Cys Thr Gly Cys Thr Cys Thr 
            580                 585                 590         


Cys Ala Cys Ala Thr Gly Gly Cys Gly Ala Ala Gly Cys Gly Gly Thr 
        595                 600                 605             


Cys Ala Ala Ala Gly Cys Gly Thr Thr Thr Cys Gly Cys Gly Ala Ala 
    610                 615                 620                 


Ala Thr Gly Ala Ala Cys Ala Thr Thr Ala Ala Gly Gly Gly Gly Ala 
625                 630                 635                 640 


Gly Cys Ala Ala Ala Ala Thr Cys Gly Gly Cys Ala Thr Thr Ala Cys 
                645                 650                 655     


Gly Cys Thr Thr Ala Ala Cys Thr Thr Gly Ala Cys Thr Cys Cys Gly 
            660                 665                 670         


Gly Cys Gly Thr Ala Thr Cys Cys Ala Gly Cys Ala Ala Gly Thr Gly 
        675                 680                 685             


Ala Gly Ala Ala Ala Gly Ala Ala Gly Ala Ala Gly Ala Thr Ala Ala 
    690                 695                 700                 


Ala Cys Thr Gly Gly Cys Thr Gly Cys Ala Cys Ala Gly Thr Ala Thr 
705                 710                 715                 720 


Gly Cys Ala Gly Ala Thr Gly Gly Cys Thr Thr Thr Gly Cys Cys Ala 
                725                 730                 735     


Ala Thr Cys Gly Cys Thr Gly Gly Thr Thr Cys Cys Thr Thr Gly Ala 
            740                 745                 750         


Cys Cys Cys Gly Ala Thr Cys Thr Thr Cys Ala Ala Gly Gly Gly Thr 
        755                 760                 765             


Ala Ala Cys Thr Ala Thr Cys Cys Gly Gly Ala Gly Gly Ala Cys Ala 
    770                 775                 780                 


Thr Gly Ala Thr Gly Gly Ala Ala Thr Thr Gly Thr Ala Cys Ala Gly 
785                 790                 795                 800 


Cys Ala Ala Ala Ala Thr Thr Ala Thr Thr Gly Gly Gly Gly Ala Ala 
                805                 810                 815     


Thr Thr Cys Gly Ala Thr Thr Thr Cys Ala Thr Thr Ala Ala Gly Gly 
            820                 825                 830         


Ala Ala Gly Gly Cys Gly Ala Thr Cys Thr Gly Gly Ala Gly Ala Cys 
        835                 840                 845             


Thr Ala Thr Cys Ala Gly Cys Gly Thr Cys Cys Cys Gly Ala Thr Thr 
    850                 855                 860                 


Gly Ala Cys Thr Thr Cys Thr Thr Ala Gly Gly Cys Ala Thr Cys Ala 
865                 870                 875                 880 


Ala Thr Thr Ala Cys Thr Ala Cys Ala Cys Thr Cys Gly Gly Ala Gly 
                885                 890                 895     


Cys Ala Thr Thr Gly Thr Thr Ala Ala Ala Thr Ala Cys Gly Ala Thr 
            900                 905                 910         


Gly Ala Ala Gly Ala Thr Thr Cys Cys Ala Thr Gly Cys Thr Gly Ala 
        915                 920                 925             


Ala Ala Gly Cys Ala Gly Ala Gly Ala Ala Cys Gly Thr Ala Cys Cys 
    930                 935                 940                 


Gly Gly Gly Ala Cys Cys Gly Gly Gly Thr Ala Ala Ala Cys Gly Thr 
945                 950                 955                 960 


Ala Cys Cys Gly Ala Ala Ala Thr Gly Gly Gly Gly Thr Gly Gly Gly 
                965                 970                 975     


Ala Ala Ala Thr Cys Thr Cys Gly Cys Cys Cys Gly Ala Gly Thr Cys 
            980                 985                 990         


Ala Cys Thr Gly Thr Ala Cys Gly  Ala Cys Thr Thr Ala  Cys Thr Gly 
        995                 1000                 1005             


Ala Ala  Ala Cys Gly Cys Thr  Thr Ala Gly Ala Cys  Cys Gly Thr 
    1010                 1015                 1020             


Gly Ala  Gly Thr Ala Thr Ala  Cys Gly Ala Ala Ala  Cys Thr Gly 
    1025                 1030                 1035             


Cys Cys  Gly Ala Thr Gly Thr  Ala Thr Ala Thr Cys  Ala Cys Cys 
    1040                 1045                 1050             


Gly Ala  Ala Ala Ala Thr Gly  Gly Ala Gly Cys Thr  Gly Cys Gly 
    1055                 1060                 1065             


Thr Thr  Thr Ala Ala Ala Gly  Ala Thr Gly Ala Ala  Gly Thr Ala 
    1070                 1075                 1080             


Ala Cys  Gly Gly Ala Ala Gly  Ala Thr Gly Gly Thr  Cys Gly Thr 
    1085                 1090                 1095             


Gly Thr  Thr Cys Ala Cys Gly  Ala Cys Gly Ala Thr  Gly Ala Ala 
    1100                 1105                 1110             


Cys Gly  Cys Ala Thr Cys Gly  Ala Ala Thr Ala Cys  Ala Thr Cys 
    1115                 1120                 1125             


Ala Ala  Ala Gly Ala Gly Cys  Ala Cys Cys Thr Gly  Ala Ala Ala 
    1130                 1135                 1140             


Gly Cys  Thr Gly Cys Cys Gly  Cys Thr Ala Ala Ala  Thr Thr Thr 
    1145                 1150                 1155             


Ala Thr  Cys Gly Gly Gly Gly  Ala Ala Gly Gly Cys  Gly Gly Thr 
    1160                 1165                 1170             


Ala Ala  Thr Cys Thr Gly Ala  Ala Ala Gly Gly Ala  Thr Ala Cys 
    1175                 1180                 1185             


Thr Thr  Thr Gly Thr Gly Thr  Gly Gly Thr Cys Ala  Thr Thr Ala 
    1190                 1195                 1200             


Ala Thr  Gly Gly Ala Cys Ala  Ala Cys Thr Thr Cys  Gly Ala Ala 
    1205                 1210                 1215             


Thr Gly  Gly Gly Cys Gly Cys  Ala Thr Gly Gly Cys  Thr Ala Cys 
    1220                 1225                 1230             


Thr Cys  Cys Ala Ala Ala Cys  Gly Thr Thr Thr Cys  Gly Gly Cys 
    1235                 1240                 1245             


Ala Thr  Thr Gly Thr Gly Thr  Ala Thr Gly Thr Gly  Gly Ala Cys 
    1250                 1255                 1260             


Thr Ala  Thr Ala Cys Gly Ala  Cys Cys Cys Ala Gly  Ala Ala Ala 
    1265                 1270                 1275             


Cys Gly  Cys Ala Thr Thr Cys  Thr Gly Ala Ala Gly  Gly Ala Thr 
    1280                 1285                 1290             


Ala Gly  Cys Gly Cys Cys Thr  Thr Gly Thr Gly Gly  Thr Ala Cys 
    1295                 1300                 1305             


Ala Ala  Ala Gly Ala Gly Gly  Thr Gly Ala Thr Thr  Cys Thr Gly 
    1310                 1315                 1320             


Gly Ala  Thr Gly Ala Thr Gly  Gly Gly Ala Thr Thr  Gly Ala Ala 
    1325                 1330                 1335             


Gly Ala  Thr 
    1340     


<210>  42
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  42
atggccaagt ttcctcgcga ctttgtatgg ggtacagcca catcgagtta tcagattgaa       60

ggcgcggtga atgaagatgg tcgtacaccg tctatctggg acaccttttc gaaaaccgag      120

ggcaaaacct ataaaggcca tacgggtgat gttgcctgtg atcactatca ccgctataag      180

gaagatgtgg aaattctgaa agaaattgga gtcaaagcct accggtttag cattgcatgg      240

ccacgtatct ttcctgagga aggcaaatac aacccgaaag gtatggattt ctacaagaaa      300

ctcattgacg aactgcaaaa gcgcgatatt gttcccgcag cgaccattta tcactgggat      360

ctgccacaat gggcctatga caaaggcggt ggctggctga accgtgagtc catcaaatgg      420

tatgtggagt acgcgaccaa attgtttgaa gaactgggtg atgcgatccc gctgtggatt      480

acccataatg agccatggtg ctcttctatc ctcagttatg gtatcggcga acatgcacct      540

ggtcataaga actatcgcga agcgcttatt gctgcgcatc acatcctgct ctcacatggc      600

gaagcggtca aagcgtttcg cgaaatgaac attaagggga gcaaaatcgg cattacgctt      660

aacttgactc cggcgtatcc agcaagtgag aaagaagaag ataaactggc tgcacagtat      720

gcagatggct ttgccaatcg ctggttcctt gacccgatct tcaagggtaa ctatccggag      780

gacatgatgg aattgtacag caaaattatt ggggaattcg atttcattaa ggaaggcgat      840

ctggagacta tcagcgtccc gattgacttc ttaggcgtca attactacac tcggagcatt      900

gttaaatacg atgaagattc catgctgaaa gcagagaacg taccgggacc gggtaaacgt      960

accgaaatgg ggtgggaaat ctcgcccgag tcactgtacg acttactgaa acgcttagac     1020

cgtgagtata cgaaactgcc gatgtatatc accgaaaatg gagctgcgtt taaagatgaa     1080

gtaacggaag atggtcgtgt tcacgacgat gaacgcatcg aatacatcaa agagcacctg     1140

aaagctgccg ctaaatttat cggggaaggc ggtaatctga aaggatactt tgtgtggtca     1200

ttaatggaca acttcgaatg ggcgcatggc tactccaaac gtttcggcat tgtgtatgtg     1260

gactatgaga cccagaaacg cattctgaag gatagcgcct tgtggtacaa agaggtgatt     1320

ctggatgatg ggattgaaga t                                               1341


<210>  43
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  43
atggccaagt ttcctcgcga ctttgtatgg ggtacagcca catcgagtta tcagattgaa       60

ggcgcggtga atgaagatgg tcgtacaccg tctatctggg acaccttttc gaaaaccgag      120

ggcaaaacct ataaaggcca tacgggtgat gttgcctgtg atcactatca ccgctataag      180

gaagatgtgg aaattctgaa agaaattgga gtcaaagcct accggtttag cattgcatgg      240

ccacgtatct ttcctgagga aggcaaatac aacccgaaag gtatggattt ctacaagaaa      300

ctcattgacg aactgcaaaa gcgcgatatt gttcccgcag cgaccattta tcactgggat      360

ctgccacaat gggcctatga caaaggcggt ggctggctga accgtgagtc catcaaatgg      420

tatgtggagt acgcgaccaa attgtttgaa gaactgggtg atgcgatccc gctgtggatt      480

acccataatg agccatggtg ctcttctatc ctcagttatg gtatcggcga acatgcacct      540

ggtcataaga actatcgcga agcgcttatt gctgcgcatc acatcctgct ctcacatggc      600

gaagcggtca aagcgtttcg cgaaatgaac attaagggga gcaaaatcgg cattacgctt      660

aacttgactc cggcgtatcc agcaagtgag aaagaagaag ataaactggc tgcacagtat      720

gcagatggct ttgccaatcg ctggttcctt gacccgatct tcaagggtaa ctatccggag      780

gacatgatgg aattgtacag caaaattatt ggggaattcg atttcattaa ggaaggcgat      840

ctggagacta tcagcgtccc gattgacttc ttaggcgtca attactacac tcggagcatt      900

gttaaatacg atgaagattc catgctgaaa gcagagaacg taccgggacc gggtaaacgt      960

accgaaatgg ggtgggaaat ctcgcccgag tcactgtacg acttactgaa acgcttagac     1020

cgtgagtata cgaaactgcc gatgtatatc accgaaaatg gagctgcgtt taaagatgaa     1080

gtaacggaag atggtcgtgt tcacgacgat gaacgcatcg aatacatcaa agagcacctg     1140

aaagctgccg ctaaatttat cggggaaggc ggtaatctga aaggatactt tgtgtggtca     1200

ttaatggaca acttcgaatg ggcgcatggc tactccaaac gtttcggcat tgtgtatgtg     1260

gactatacga cccagaaacg cattctgaag gatagcgcct tgtggtacaa agaggtgatt     1320

cgtgatgatg ggattgaaga t                                               1341


<210>  44
<211>  447
<212>  PRT
<213>  Thermoanaerobacter brockii

<400>  44

Met Ala Lys Phe Pro Arg Asp Phe Val Trp Gly Thr Ala Thr Ser Ser 
1               5                   10                  15      


Tyr Gln Ile Glu Gly Ala Val Asn Glu Asp Gly Arg Thr Pro Ser Ile 
            20                  25                  30          


Trp Asp Thr Phe Ser Lys Thr Glu Gly Lys Thr Tyr Lys Gly His Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Lys Glu Asp Val Glu 
    50                  55                  60                  


Ile Leu Lys Glu Ile Gly Val Lys Ala Tyr Arg Phe Ser Ile Ala Trp 
65                  70                  75                  80  


Pro Arg Ile Phe Pro Glu Glu Gly Lys Tyr Asn Pro Lys Gly Met Asp 
                85                  90                  95      


Phe Tyr Lys Lys Leu Ile Asp Glu Leu Gln Lys Arg Asp Ile Val Pro 
            100                 105                 110         


Ala Ala Thr Ile Tyr His Trp Asp Leu Pro Gln Trp Ala Tyr Asp Lys 
        115                 120                 125             


Gly Gly Gly Trp Leu Asn Arg Glu Ser Ile Lys Trp Tyr Val Glu Tyr 
    130                 135                 140                 


Ala Thr Lys Leu Phe Glu Glu Leu Gly Asp Ala Ile Pro Leu Trp Ile 
145                 150                 155                 160 


Thr His Asn Glu Pro Trp Cys Ser Ser Ile Leu Ser Tyr Gly Ile Gly 
                165                 170                 175     


Glu His Ala Pro Gly His Lys Asn Tyr Arg Glu Ala Leu Ile Ala Ala 
            180                 185                 190         


His His Ile Leu Leu Ser His Gly Glu Ala Val Lys Ala Phe Arg Glu 
        195                 200                 205             


Met Asn Ile Lys Gly Ser Lys Ile Gly Ile Thr Leu Asn Leu Thr Pro 
    210                 215                 220                 


Ala Tyr Pro Ala Ser Glu Lys Glu Glu Asp Lys Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Ala Asp Gly Phe Ala Asn Arg Trp Phe Leu Asp Pro Ile Phe Lys Gly 
                245                 250                 255     


Asn Tyr Pro Glu Asp Met Met Glu Leu Tyr Ser Lys Ile Ile Gly Glu 
            260                 265                 270         


Phe Asp Phe Ile Lys Glu Gly Asp Leu Glu Thr Ile Ser Val Pro Ile 
        275                 280                 285             


Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ser Ile Val Lys Tyr Asp 
    290                 295                 300                 


Glu Asp Ser Met Leu Lys Ala Glu Asn Val Pro Gly Pro Gly Lys Arg 
305                 310                 315                 320 


Thr Glu Met Gly Trp Glu Ile Ser Pro Glu Ser Leu Tyr Asp Leu Leu 
                325                 330                 335     


Lys Arg Leu Asp Arg Glu Tyr Thr Lys Leu Pro Met Tyr Ile Thr Glu 
            340                 345                 350         


Asn Gly Ala Ala Phe Lys Asp Glu Val Thr Glu Asp Gly Arg Val His 
        355                 360                 365             


Asp Asp Glu Arg Ile Glu Tyr Ile Lys Glu His Leu Lys Ala Ala Ala 
    370                 375                 380                 


Lys Phe Ile Gly Glu Gly Gly Asn Leu Lys Gly Tyr Phe Val Trp Ser 
385                 390                 395                 400 


Leu Met Asp Asn Phe Glu Trp Ala His Gly Tyr Ser Lys Arg Phe Gly 
                405                 410                 415     


Ile Val Tyr Val Asp Tyr Thr Thr Gln Lys Arg Ile Leu Lys Asp Ser 
            420                 425                 430         


Ala Leu Trp Tyr Lys Glu Val Ile Leu Asp Asp Gly Ile Glu Asp 
        435                 440                 445         


<210>  45
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutagenesis Primer

<400>  45
agcgcgatat taaacccgca gcgaccattt atc                                    33


<210>  46
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutagenesis Primer

<400>  46
gataaatggt cgctgcgggt ttaatatcgc gct                                    33


<210>  47
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutragenesis Primer

<400>  47
cgattgactt cttaggcatc aattactaca ctc                                    33


<210>  48
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutagenesis Primer

<400>  48
gagtgtagta attgatgcct aagaagtcaa tcg                                    33


<210>  49
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutagenesis Primer

<400>  49
attgtgtatg tggactatga gacccagaaa cg                                     32


<210>  50
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutegenesis Primer

<400>  50
cgtttctggg tctcatagtc cacatacaca at                                     32


<210>  51
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutagenesis Primer

<400>  51
acaaagaggt gattcgcgat gatgggattg aag                                    33


<210>  52
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutagenesis Primer

<400>  52
cttcaatccc atcatcgcga atcacctctt tgt                                    33


