                         SEQUENCE LISTING

<110>  INSTITUT NATIONAL TRANSFUSION SANGUINE
       INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 
       (INSERM)
       UNIVERSITE PARIS DIDEROT PARIS 7
 
<120>  PROCEDE DE PRODUCTION DE PROTEINES ERYTHROCYTAIRES

<130>  B371202D35276

<150>  FR1559895
<151>  16-10-2015

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  2549
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  RHD

<400>  1
ggtgttggag agaggggtga tgcctggtgc tggtggaacc cctgcacaga gacggacaca       60

ggatgagctc taagtacccg cggtctgtcc ggcgctgcct gcccctctgg gccctaacac      120

tggaagcagc tctcattctc ctcttctatt tttttaccca ctatgacgct tccttagagg      180

atcaaaaggg gctcgtggca tcctatcaag ttggccaaga tctgaccgtg atggcggcca      240

ttggcttggg cttcctcacc tcgagtttcc ggagacacag ctggagcagt gtggccttca      300

acctcttcat gctggcgctt ggtgtgcagt gggcaatcct gctggacggc ttcctgagcc      360

agttcccttc tgggaaggtg gtcatcacac tgttcagtat tcggctggcc accatgagtg      420

ctttgtcggt gctgatctca gtggatgctg tcttggggaa ggtcaacttg gcgcagttgg      480

tggtgatggt gctggtggag gtgacagctt taggcaacct gaggatggtc atcagtaata      540

tcttcaacac agactaccac atgaacatga tgcacatcta cgtgttcgca gcctattttg      600

ggctgtctgt ggcctggtgc ctgccaaagc ctctacccga gggaacggag gataaagatc      660

agacagcaac gatacccagt ttgtctgcca tgctgggcgc cctcttcttg tggatgttct      720

ggccaagttt caactctgct ctgctgagaa gtccaatcga aaggaagaat gccgtgttca      780

acacctacta tgctgtagca gtcagcgtgg tgacagccat ctcagggtca tccttggctc      840

acccccaagg gaagatcagc aagacttatg tgcacagtgc ggtgttggca ggaggcgtgg      900

ctgtgggtac ctcgtgtcac ctgatccctt ctccgtggct tgccatggtg ctgggtcttg      960

tggctgggct gatctccgtc gggggagcca agtacctgcc gtttcctcat ttggctgttg     1020

gattttaagc aaaagcatcc aagaaaaaca aggcctgttc aaaaacaaga caacttcctc     1080

tcactgttgc ctgcatttgt acgtgagaaa cgctcatgac agcaaagtct ccaatgttcg     1140

cgcaggcact ggagtcagag aaaatggagt tgaatccttt ctctgccact ctttgaggag     1200

aatctcacca tttattatgc actgtagaat acaacaataa aatacagcca tgtaccacat     1260

aacaacatct tggtaaacaa cagactgcat atatgatggt ggtcatccag taagctaagg     1320

ttaatttatt attattcctt gttttttttt tttttttttt ttttttgaga tgtagtctta     1380

ctctgtcacc caggctagag tgcaatggca ccatcttggc tcactgcaac ctctacctcc     1440

tgggttcaag caaatctcct gcctcagcct ccaaagtagc tgggattaca ggcacccacc     1500

acatctggct aattttttgt atttttagta aagatggggt ttcaccatgt tggccaggct     1560

gatctcaaac tcctgacctc aagtgatctg cccgcctcgg cctcccaaag tgctggaacc     1620

acaggcctga gccactgtgc ccagccttgt ttgctttttt aacagataac agtgtgctca     1680

tagaaactgc tttgacatga ctgcaatcat gtgcttcata gaaacttaat tagattatac     1740

cactagagtc ttcagatttt tatacttttt ttttttgaaa cggagtctca ctctgtcacc     1800

aggctggagt gcagtgccgc aatctcggct cactgcaacc tccgcctccc aggttcaagc     1860

aattctcctg cctcagcctc ccgagtagct ggaattacaa gtgcgcacta ccacacccag     1920

ctaatttttg catttttact tgacagggtt tcaccatgtt ggctaggata gtttcaccag     1980

gatctcttgg cctcatgatc agcctgcctc ggcctcccaa agtgctggga ttacaggtgt     2040

gagccaccgt gcccagccta tacttccctt tttgaatacc atttggtgtt ttgaagaatt     2100

aacagctttg tgaacgtggc agtgcttgtg attcaggctt ccattgagac caaggggaga     2160

acctggttgc aggacaaaca gacggacagc gtgtggcagt gtttaaatgc tcttctgaag     2220

gctgatacga cagctctctg tgcactgatt gcatatgcat cccaagatta tattattgtt     2280

ttctactgct atgtgtcaca ctttgccaaa caggatgtgg aaaatgaata agcggttttc     2340

ttaggcactt cttaacagac aattggtcaa aatgaactcc attgcttaag aaacacataa     2400

acaccattta gtcactgaac atagctatat gtatggttgt tactatggga aatcttgttt     2460

tgccaatttt ctttgaaaat tctggcagac caaggttctt tttgtttaca taatacttga     2520

aaaataaaaa tgaacaagct aacaaacta                                       2549


<210>  2
<211>  1618
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  RHCE

<400>  2
atcgctccct caagccctca agtaggtgtt ggagagaggg gtgatgcctg gtgctggtgg       60

aacccctgca cagagacgga cacaggatga gctctaagta cccgcggtct gtccggcgct      120

gcctgcccct ctgggcccta acactggaag cagctctcat tctcctcttc tattttttta      180

cccactatga cgcttcctta gaggatcaaa aggggctcgt ggcatcctat caagtcggcc      240

aagatctgac cgtgatggcg gcccttggct tgggcttcct cacctcaaat ttccggagac      300

acagctggag cagtgtggcc ttcaacctct tcatgctggc gcttggtgtg cagtgggcaa      360

tcctgctgga cggcttcctg agccagttcc ctcctgggaa ggtggtcatc acactgttca      420

gtattcggct ggccaccatg agtgctatgt cggtgctgat ctcagcgggt gctgtcttgg      480

ggaaggtcaa cttggcgcag ttggtggtga tggtgctggt ggaggtgaca gctttaggca      540

ccctgaggat ggtcatcagt aatatcttca acacagacta ccacatgaac ctgaggcact      600

tctacgtgtt cgcagcctat tttgggctga ctgtggcctg gtgcctgcca aagcctctac      660

ccaagggaac ggaggataat gatcagagag caacgatacc cagtttgtct gccatgctgg      720

gcgccctctt cttgtggatg ttctggccaa gtgtcaactc tgctctgctg agaagtccaa      780

tccaaaggaa gaatgccatg ttcaacacct actatgctct agcagtcagt gtggtgacag      840

ccatctcagg gtcatccttg gctcaccccc aaaggaagat cagcatgact tatgtgcaca      900

gtgcggtgtt ggcaggaggc gtggctgtgg gtacctcgtg tcacctgatc ccttctccgt      960

ggcttgccat ggtgctgggt cttgtggctg ggctgatctc catcggggga gccaagtgcc     1020

tgccggtgtg ttgtaaccga gtgctgggga ttcaccacat ctccgtcatg cactccatct     1080

tcagcttgct gggtctgctt ggagagatca cctacattgt gctgctggtg cttcatactg     1140

tctggaacgg caatggcatg attggcttcc aggtcctcct cagcattggg gaactcagct     1200

tggccatcgt gatagctctc acgtctggtc tcctgacagg tttgctccta aatctcaaaa     1260

tatggaaagc acctcatgtg gctaaatatt ttgatgacca agttttctgg aagtttcctc     1320

atttggctgt tggattttaa gcaaaagcat ccaagaaaaa caaggcctgt tcaaaaacaa     1380

gacaacttcc tctcactgtt gcctgcattt gtacgtgaga aacgctcatg acagcaaagt     1440

ctccttatgt ataatgaaac aaggtcagag acagatttga tattaaaaaa ttaaagacta     1500

aaaacttagt ttaagagtca atttaataag tttaaaataa atgtttagtt tcattaggat     1560

gatgctatca atattttctt ggttacagac acattattaa agttttgggt taatttta       1618


<210>  3
<211>  3836
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  RHAG

<400>  3
gttcttatca acatctcaca gcctgtgaag ctctcagtgt gcctctgtcc tttgccacaa       60

acatgaggtt cacattccct ctcatggcta tagtcctgga aattgccatg attgttttat      120

ttggattatt tgttgagtat gaaacggacc agactgttct cgagcagctc aacatcacca      180

agccaacaga catgggcata ttctttgagt tatatcctct gttccaagat gtacatgtta      240

tgatatttgt tgggtttggc ttcctcatga ccttcctgaa gaaatatggc ttcagcagtg      300

tgggtatcaa cctactcgtt gctgctttgg gcctccagtg gggcactatt gtacagggaa      360

tcctgcaaag ccagggacag aaatttaaca ttggaatcaa aaacatgata aatgcagact      420

tcagtgcagc cacagttctg atatcttttg gagctgtcct gggaaaaacg agccccaccc      480

aaatgctgat gttcttatca acatctcaca gcctgtgaag ctctcagtgt gcctctgtcc      540

tttgccacaa acatgaggtt cacattccct ctcatggcta tagtcctgga aattgccatg      600

attgttttat ttggattatt tgttgagtat gaaacggacc agactgttct cgagcagctc      660

aacatcacca agccaacaga catgggcata ttctttgagt tatatcctct gttccaagat      720

gtacatgtta tgatatttgt tgggtttggc ttcctcatga ccttcctgaa gaaatatggc      780

ttcagcagtg tgggtatcaa cctactcgtt gctgctttgg gcctccagtg gggcactatt      840

gtacagggaa tcctgcaaag ccagggacag aaatttaaca ttggaatcaa aaacatgata      900

aatgcagact tcagtgcagc cacagttctg atatcttttg gagctgtcct gggaaaaacg      960

agccccaccc aaatgctgat catgacaatt ttagaaattg ttttctttgc ccacaatgaa     1020

tacctggtta gtgaaatatt taaggcctct gacattggag catcaatgac gatccatgcc     1080

tttggggcct actttggctt ggctgtagca ggcatcttgt atcgatctgg actgagaaag     1140

gggcatgaaa atgaagagtc cgcatactac tcagacttgt ttgcaatgat tgggactctc     1200

tttctgtgga tgttttggcc cagctttaac tcggccattg ctgaacctgg agacaaacag     1260

tgcagggcca ttgtaaacac gtacttctct ctcgctgcct gtgtgctcac agcctttgcc     1320

ttctccagcc tagtggagca ccgaggcaag ctcaacatgg ttcacattca gaatgccacc     1380

cttgctggag gagttgctgt gggcacttgt gcggatatgg caattcaccc atttggttct     1440

atgattattg ggagcattgc aggaatggtc tctgtgcttg gatacaagtt cctgactcca     1500

ctttttacta ctaaactgag gatccatgat acatgtgggg tccataacct ccacggctta     1560

cctggtgtag tgggaggcct tgcaggcatt gtggcagtag caatgggcgc ctccaacacg     1620

tctatggcca tgcaggcagc tgcactgggt tcctctatcg gaacagcagt tgttggaggt     1680

ctgatgacag gtttaattct aaagttgcct ctctggggac agccatctga ccagaactgc     1740

tatgatgatt ctgtttattg gaaggtccct aagacgagat aacttgacaa tcagttccat     1800

ggacatggtg accacagcca gctggaacct gaagtctaaa caccattcct gctctccagc     1860

ttcctttccc attatccaga atcaagtcca aataaacaaa aagggagtaa ccaaagagag     1920

tatggaccag agtgaataga tcctaagtcc caaatggcca gtgtaaaaat gtccttatgt     1980

ctgatgctgt ctcttgctct tcaatgatta attgagggga tgttactcat aaaacagata     2040

atcaaataga tcttctccag gattcccaaa aagcttttgg cagtgagtaa atacagagta     2100

aacatgtcag tttcttaatg tagacactat gtcttcaatc ccaaaaatta taaaactgaa     2160

acccatgaag caagaataga tgtgagaaat ctatgtaaaa aaataattaa agaaatgcat     2220

gtgtgtaaag tagtaatatg atgattttag gtagtgcttt ttattttaaa aatagtctag     2280

ttagtaatgt tgtatccttg catgaatatt attcttaatt ccttttgcat gttgactatt     2340

tgcaacgagc tcaaatgcta tctgatcaaa gtctattttg cataaaatgt ccaataatta     2400

aatattgtta taaaataaaa aaaaaaaaaa aaaaaaaaaa aaagacattg gagcatcaat     2460

gacgatccat gcctttgggg cctactttgg cttggctgta gcaggcatct tgtatcgatc     2520

tggactgaga aaggggcatg aaaatgaaga gtccgcatac tactcagact tgtttgcaat     2580

gattgggact ctctttctgt ggatgttttg gcccagcttt aactcggcca ttgctgaacc     2640

tggagacaaa cagtgcaggg ccattgtaaa cacgtacttc tctctcgctg cctgtgtgct     2700

cacagccttt gccttctcca gcctagtgga gcaccgaggc aagctcaaca tggttcacat     2760

tcagaatgcc acccttgctg gaggagttgc tgtgggcact tgtgcggata tggcaattca     2820

cccatttggt tctatgatta ttgggagcat tgcaggaatg gtctctgtgc ttggatacaa     2880

gttcctgact ccacttttta ctactaaact gaggatccat gatacatgtg gggtccataa     2940

cctccacggc ttacctggtg tagtgggagg ccttgcaggc attgtggcag tagcaatggg     3000

cgcctccaac acgtctatgg ccatgcaggc agctgcactg ggttcctcta tcggaacagc     3060

agttgttgga ggtctgatga caggtttaat tctaaagttg cctctctggg gacagccatc     3120

tgaccagaac tgctatgatg attctgttta ttggaaggtc cctaagacga gataacttga     3180

caatcagttc catggacatg gtgaccacag ccagctggaa cctgaagtct aaacaccatt     3240

cctgctctcc agcttccttt cccattatcc agaatcaagt ccaaataaac aaaaagggag     3300

taaccaaaga gagtatggac cagagtgaat agatcctaag tcccaaatgg ccagtgtaaa     3360

aatgtcctta tgtctgatgc tgtctcttgc tcttcaatga ttaattgagg ggatgttact     3420

cataaaacag ataatcaaat agatcttctc caggattccc aaaaagcttt tggcagtgag     3480

taaatacaga gtaaacatgt cagtttctta atgtagacac tatgtcttca atcccaaaaa     3540

ttataaaact gaaacccatg aagcaagaat agatgtgaga aatctatgta aaaaaataat     3600

taaagaaatg catgtgtgta aagtagtaat atgatgattt taggtagtgc tttttatttt     3660

aaaaatagtc tagttagtaa tgttgtatcc ttgcatgaat attattctta attccttttg     3720

catgttgact atttgcaacg agctcaaatg ctatctgatc aaagtctatt ttgcataaaa     3780

tgtccaataa ttaaatattg ttataaaata aaaaaaaaaa aaaaaaaaaa aaaaaa         3836


<210>  4
<211>  4129
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  SLC14A1

<400>  4
acacagagca gagtggggct ctgagtatat aactgttagg tgcctccctc cagcaccatc       60

tcctgagaag cactctccct tgtcgtggag gtgggcaaat ctttatcagc cactgccttc      120

tgctgccagg aagccagcta gagtggtctt taaagaaaac tgggcatctc ctgctactta      180

aaatcaaaaa ctacctaaaa taaagattat aaaaaagtaa ggatgaatgg acggtctttg      240

attggcggcg ctggtgacgc ccgtcatggt cctgtttgga aggacccttt tggaactaaa      300

gctggtgacg cagcgcgcag aggcatcgcc cggctaagct tggccctggc agatgggtcg      360

caggaacagg agccagagga agagatagcc atggaggaca gccccactat ggttagagtg      420

gacagcccca ctatggttag gggtgaaaac caggtttcgc catgtcaagg gagaaggtgc      480

ttccccaaag ctcttggcta tgtcaccggt gacatgaaag aacttgccaa ccagcttaaa      540

gacaaacccg tggtgctcca gttcattgac tggattctcc ggggcatatc ccaagtggtg      600

ttcgtcaaca accccgtcag tggaatcctg attctggtag gacttcttgt tcagaacccc      660

tggtgggctc tcactggctg gctgggaaca gtggtctcca ctctgatggc cctcttgctc      720

agccaggaca ggtcattaat agcatctggg ctctatggct acaatgccac cctggtggga      780

gtactcatgg ctgtcttttc ggacaaggga gactatttct ggtggctgtt actccctgta      840

tgtgctatgt ccatgacttg cccaattttc tcaagtgcat tgaattccat gctcagcaaa      900

tgggacctcc ccgtcttcac cctccctttc aacatggcgt tgtcaatgta cctttcagcc      960

acaggacatt acaatccatt ctttccagcc aaactggtca tacctataac tacagctcca     1020

aatatctcct ggtctgacct cagtgccctg gagttgttga aatctatacc agtgggagtt     1080

ggtcagatct atggctgtga taatccatgg acagggggca ttttcctggg agccatccta     1140

ctctcctccc cactcatgtg cctgcatgct gccataggat cattgctggg catagcagcg     1200

ggactcagtc tttcagcccc atttgaggac atctactttg gactctgggg tttcaacagc     1260

tctctggcct gcattgcaat gggaggaatg ttcatggcgc tcacctggca aacccacctc     1320

ctggctcttg gctgtgccct gttcacggcc tatcttggag tcggcatggc aaactttatg     1380

gctgaggttg gattgccagc ttgtacctgg cccttctgtt tggccacgct attgttcctc     1440

atcatgacca caaaaaattc caacatctac aagatgcccc tcagtaaagt tacttatcct     1500

gaagaaaacc gcatcttcta cctgcaagcc aagaaaagaa tggtggaaag ccctttgtga     1560

gaacaagccc catttgcagc catggtcacg agtcatttct gcctgactgc tccagctaac     1620

ttccagggtc tcagcaaact gctgtttttc acgagtatca actttcatac tgacgcgtct     1680

gtaatctgtt cttatgctca ttttgtattt tcctttcaac tccaggaata tccttgagca     1740

tatgagagtc acatccaggt gatgtgctct ggtatggaat ttgaaacccc aatggggcct     1800

tggcactaag actggaatgt atataaagtc aaagtgctcc aacagaagga ggaagtgaaa     1860

acaaactatt agtatttatt gatattcttg gtgtttagct ggctcgatga tgttaacagt     1920

attaaaaatt aaaccccata aaccaactaa gccttatgga attcacagtc acaaaatcga     1980

agttaatcca gaattctgtg ataagcagct tggctttttt tttaaatcaa tgcaagttac     2040

acattatagc cagaatctgt atcacagagg tgcaagctga cagcagagct cagtccccac     2100

ttcctgcaaa caatggcctg caccctatcc cttgtgtgtg tgacattctc tcatgggaca     2160

atgttggggt ttttcagact gacaggactg caagagggag aaaggaattt tgtcaatcaa     2220

aattattctg tattgcaact tttctcagag attgcaaagg attttttagg tagagattat     2280

ttttccttat gaaaaatgat ctgttttaaa tgagataaaa taggagaagt tcctggctta     2340

acctgttctt acatattaaa gaaaagttac ttactgtatt tatgaaatac tcagcttagg     2400

catttttact ttaaccccta aattgatttt gtaaatgcca caaatgcata gaattgttac     2460

caacctccaa agggctcttt aaaatcatat tttttattca tttgaggatg tcttataaag     2520

actgaaggca aaggtcagat tgcttacggg tgttattttt ataagttgtt gaattcctta     2580

atttaaaaaa gctcattatt ttttgcacac tcacaatatt ctctctcaga aatcaatggc     2640

atttgaacca ccaaaaagaa ataaagggct gagtgcggtg gctcacgcct gtaatcccag     2700

cactttgggg agcccaggcg ggcagattgc ttgaacccag gagttcaaga ccagcctggg     2760

cagcatggtg aaaccctgta tctacaaaaa atacaaaaat tagccaggca tggtggtggg     2820

tgcctgtagt tccagctact tgggaggctg aggtgggaaa atgacttgag cccaggagga     2880

ggaggctgca gtgagctaag attgcaccac tgcactccaa cctgggcgac aagagtgaaa     2940

ctgtgtctct caaaaaaaaa aaaaaacaaa caaaaacaaa aacaaaacaa aacaaaacaa     3000

aacaaaacag gtaaggattc ccctgttttc ctctctttaa ttttaaagtt atcagttccg     3060

taaagtctct gtaaccaaac atactgaaga cagcaacaga agtcacgttc agggactggc     3120

tcacacctgt aatcccagca ctttgggaga tggaggtaaa aggatctctt gagcccagga     3180

gttcaagacc agcttgggca acatagcaag actccatctc ttaaaaaata aaaatagtaa     3240

cattagccag gtgtagcagc acacatctgc agcagctact caggaggctg aggtggaaag     3300

atcgcttgtg cacagaagtt cgaggctgca gtgagctata tgatcatgtc actgcactcc     3360

agcctgtgtg accgagcaag accctatctc aaaaaaatta attaattaat taattaatta     3420

atttaaaaag gaagtcatgt tcatttactt tccacttcag tgtgtatcgt gtagtatttt     3480

ggaggttgga aagtgaaacg taggaatcct gaagattttt tccacttcta gtttgcagtg     3540

ctcagtgcac aatatacatt ttgctgaatg aataaacaga aatagggaag taaacctaca     3600

aatattttag ggagaagctc acttcttcct tttctcagga aaccaagcaa gcaaacatat     3660

cgttccaatt ttaaaaccca gtgaccaaag cctttggaac tatgaatttg caactgtcat     3720

aggtttatgg atattgctgt ggagaagctc aattttcagt gtttgaactg aaccctttct     3780

tgttagggaa cgtgtgaaag aagaattgtg gggaaaaaaa agcaagcata accaaagatc     3840

atcagcagtg aagaatctag gctgtggctg agagaaccag aggcctctaa aatggacccg     3900

agtcgatctt cagaacaggg atctaccatg caggagcttc ttgtgctcac acaaatctgt     3960

aaatgggaac attgtacatt gtcgaattta aatgatatta attttctcaa gctatttttg     4020

ttactatttt cctaaaattg aatatttgca gggagcactt atactttttc ctaatgtctg     4080

tataacaaat ttctatgcaa gtacatgaat aaattatgct cacagctca                 4129


<210>  5
<211>  321
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SITE
<222>  (1)..(321)
<223>  RhD

<400>  5

Met Ser Ser Lys Tyr Pro Arg Ser Val Arg Arg Cys Leu Pro Leu Trp 
1               5                   10                  15      


Ala Leu Thr Leu Glu Ala Ala Leu Ile Leu Leu Phe Tyr Phe Phe Thr 
            20                  25                  30          


His Tyr Asp Ala Ser Leu Glu Asp Gln Lys Gly Leu Val Ala Ser Tyr 
        35                  40                  45              


Gln Val Gly Gln Asp Leu Thr Val Met Ala Ala Ile Gly Leu Gly Phe 
    50                  55                  60                  


Leu Thr Ser Ser Phe Arg Arg His Ser Trp Ser Ser Val Ala Phe Asn 
65                  70                  75                  80  


Leu Phe Met Leu Ala Leu Gly Val Gln Trp Ala Ile Leu Leu Asp Gly 
                85                  90                  95      


Phe Leu Ser Gln Phe Pro Ser Gly Lys Val Val Ile Thr Leu Phe Ser 
            100                 105                 110         


Ile Arg Leu Ala Thr Met Ser Ala Leu Ser Val Leu Ile Ser Val Asp 
        115                 120                 125             


Ala Val Leu Gly Lys Val Asn Leu Ala Gln Leu Val Val Met Val Leu 
    130                 135                 140                 


Val Glu Val Thr Ala Leu Gly Asn Leu Arg Met Val Ile Ser Asn Ile 
145                 150                 155                 160 


Phe Asn Thr Asp Tyr His Met Asn Met Met His Ile Tyr Val Phe Ala 
                165                 170                 175     


Ala Tyr Phe Gly Leu Ser Val Ala Trp Cys Leu Pro Lys Pro Leu Pro 
            180                 185                 190         


Glu Gly Thr Glu Asp Lys Asp Gln Thr Ala Thr Ile Pro Ser Leu Ser 
        195                 200                 205             


Ala Met Leu Gly Ala Leu Phe Leu Trp Met Phe Trp Pro Ser Phe Asn 
    210                 215                 220                 


Ser Ala Leu Leu Arg Ser Pro Ile Glu Arg Lys Asn Ala Val Phe Asn 
225                 230                 235                 240 


Thr Tyr Tyr Ala Val Ala Val Ser Val Val Thr Ala Ile Ser Gly Ser 
                245                 250                 255     


Ser Leu Ala His Pro Gln Gly Lys Ile Ser Lys Thr Tyr Val His Ser 
            260                 265                 270         


Ala Val Leu Ala Gly Gly Val Ala Val Gly Thr Ser Cys His Leu Ile 
        275                 280                 285             


Pro Ser Pro Trp Leu Ala Met Val Leu Gly Leu Val Ala Gly Leu Ile 
    290                 295                 300                 


Ser Val Gly Gly Ala Lys Tyr Leu Pro Phe Pro His Leu Ala Val Gly 
305                 310                 315                 320 


Phe 
    


<210>  6
<211>  417
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SITE
<222>  (1)..(417)
<223>  RhCE

<400>  6

Met Ser Ser Lys Tyr Pro Arg Ser Val Arg Arg Cys Leu Pro Leu Trp 
1               5                   10                  15      


Ala Leu Thr Leu Glu Ala Ala Leu Ile Leu Leu Phe Tyr Phe Phe Thr 
            20                  25                  30          


His Tyr Asp Ala Ser Leu Glu Asp Gln Lys Gly Leu Val Ala Ser Tyr 
        35                  40                  45              


Gln Val Gly Gln Asp Leu Thr Val Met Ala Ala Leu Gly Leu Gly Phe 
    50                  55                  60                  


Leu Thr Ser Asn Phe Arg Arg His Ser Trp Ser Ser Val Ala Phe Asn 
65                  70                  75                  80  


Leu Phe Met Leu Ala Leu Gly Val Gln Trp Ala Ile Leu Leu Asp Gly 
                85                  90                  95      


Phe Leu Ser Gln Phe Pro Pro Gly Lys Val Val Ile Thr Leu Phe Ser 
            100                 105                 110         


Ile Arg Leu Ala Thr Met Ser Ala Met Ser Val Leu Ile Ser Ala Gly 
        115                 120                 125             


Ala Val Leu Gly Lys Val Asn Leu Ala Gln Leu Val Val Met Val Leu 
    130                 135                 140                 


Val Glu Val Thr Ala Leu Gly Thr Leu Arg Met Val Ile Ser Asn Ile 
145                 150                 155                 160 


Phe Asn Thr Asp Tyr His Met Asn Leu Arg His Phe Tyr Val Phe Ala 
                165                 170                 175     


Ala Tyr Phe Gly Leu Thr Val Ala Trp Cys Leu Pro Lys Pro Leu Pro 
            180                 185                 190         


Lys Gly Thr Glu Asp Asn Asp Gln Arg Ala Thr Ile Pro Ser Leu Ser 
        195                 200                 205             


Ala Met Leu Gly Ala Leu Phe Leu Trp Met Phe Trp Pro Ser Val Asn 
    210                 215                 220                 


Ser Ala Leu Leu Arg Ser Pro Ile Gln Arg Lys Asn Ala Met Phe Asn 
225                 230                 235                 240 


Thr Tyr Tyr Ala Leu Ala Val Ser Val Val Thr Ala Ile Ser Gly Ser 
                245                 250                 255     


Ser Leu Ala His Pro Gln Arg Lys Ile Ser Met Thr Tyr Val His Ser 
            260                 265                 270         


Ala Val Leu Ala Gly Gly Val Ala Val Gly Thr Ser Cys His Leu Ile 
        275                 280                 285             


Pro Ser Pro Trp Leu Ala Met Val Leu Gly Leu Val Ala Gly Leu Ile 
    290                 295                 300                 


Ser Ile Gly Gly Ala Lys Cys Leu Pro Val Cys Cys Asn Arg Val Leu 
305                 310                 315                 320 


Gly Ile His His Ile Ser Val Met His Ser Ile Phe Ser Leu Leu Gly 
                325                 330                 335     


Leu Leu Gly Glu Ile Thr Tyr Ile Val Leu Leu Val Leu His Thr Val 
            340                 345                 350         


Trp Asn Gly Asn Gly Met Ile Gly Phe Gln Val Leu Leu Ser Ile Gly 
        355                 360                 365             


Glu Leu Ser Leu Ala Ile Val Ile Ala Leu Thr Ser Gly Leu Leu Thr 
    370                 375                 380                 


Gly Leu Leu Leu Asn Leu Lys Ile Trp Lys Ala Pro His Val Ala Lys 
385                 390                 395                 400 


Tyr Phe Asp Asp Gln Val Phe Trp Lys Phe Pro His Leu Ala Val Gly 
                405                 410                 415     


Phe 
    


<210>  7
<211>  409
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SITE
<222>  (1)..(409)
<223>  RhAG

<400>  7

Met Arg Phe Thr Phe Pro Leu Met Ala Ile Val Leu Glu Ile Ala Met 
1               5                   10                  15      


Ile Val Leu Phe Gly Leu Phe Val Glu Tyr Glu Thr Asp Gln Thr Val 
            20                  25                  30          


Leu Glu Gln Leu Asn Ile Thr Lys Pro Thr Asp Met Gly Ile Phe Phe 
        35                  40                  45              


Glu Leu Tyr Pro Leu Phe Gln Asp Val His Val Met Ile Phe Val Gly 
    50                  55                  60                  


Phe Gly Phe Leu Met Thr Phe Leu Lys Lys Tyr Gly Phe Ser Ser Val 
65                  70                  75                  80  


Gly Ile Asn Leu Leu Val Ala Ala Leu Gly Leu Gln Trp Gly Thr Ile 
                85                  90                  95      


Val Gln Gly Ile Leu Gln Ser Gln Gly Gln Lys Phe Asn Ile Gly Ile 
            100                 105                 110         


Lys Asn Met Ile Asn Ala Asp Phe Ser Ala Ala Thr Val Leu Ile Ser 
        115                 120                 125             


Phe Gly Ala Val Leu Gly Lys Thr Ser Pro Thr Gln Met Leu Ile Met 
    130                 135                 140                 


Thr Ile Leu Glu Ile Val Phe Phe Ala His Asn Glu Tyr Leu Val Ser 
145                 150                 155                 160 


Glu Ile Phe Lys Ala Ser Asp Ile Gly Ala Ser Met Thr Ile His Ala 
                165                 170                 175     


Phe Gly Ala Tyr Phe Gly Leu Ala Val Ala Gly Ile Leu Tyr Arg Ser 
            180                 185                 190         


Gly Leu Arg Lys Gly His Glu Asn Glu Glu Ser Ala Tyr Tyr Ser Asp 
        195                 200                 205             


Leu Phe Ala Met Ile Gly Thr Leu Phe Leu Trp Met Phe Trp Pro Ser 
    210                 215                 220                 


Phe Asn Ser Ala Ile Ala Glu Pro Gly Asp Lys Gln Cys Arg Ala Ile 
225                 230                 235                 240 


Val Asn Thr Tyr Phe Ser Leu Ala Ala Cys Val Leu Thr Ala Phe Ala 
                245                 250                 255     


Phe Ser Ser Leu Val Glu His Arg Gly Lys Leu Asn Met Val His Ile 
            260                 265                 270         


Gln Asn Ala Thr Leu Ala Gly Gly Val Ala Val Gly Thr Cys Ala Asp 
        275                 280                 285             


Met Ala Ile His Pro Phe Gly Ser Met Ile Ile Gly Ser Ile Ala Gly 
    290                 295                 300                 


Met Val Ser Val Leu Gly Tyr Lys Phe Leu Thr Pro Leu Phe Thr Thr 
305                 310                 315                 320 


Lys Leu Arg Ile His Asp Thr Cys Gly Val His Asn Leu His Gly Leu 
                325                 330                 335     


Pro Gly Val Val Gly Gly Leu Ala Gly Ile Val Ala Val Ala Met Gly 
            340                 345                 350         


Ala Ser Asn Thr Ser Met Ala Met Gln Ala Ala Ala Leu Gly Ser Ser 
        355                 360                 365             


Ile Gly Thr Ala Val Val Gly Gly Leu Met Thr Gly Leu Ile Leu Lys 
    370                 375                 380                 


Leu Pro Leu Trp Gly Gln Pro Ser Asp Gln Asn Cys Tyr Asp Asp Ser 
385                 390                 395                 400 


Val Tyr Trp Lys Val Pro Lys Thr Arg 
                405                 


<210>  8
<211>  445
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SITE
<222>  (1)..(445)
<223>  UTB

<400>  8

Met Asn Gly Arg Ser Leu Ile Gly Gly Ala Gly Asp Ala Arg His Gly 
1               5                   10                  15      


Pro Val Trp Lys Asp Pro Phe Gly Thr Lys Ala Gly Asp Ala Ala Arg 
            20                  25                  30          


Arg Gly Ile Ala Arg Leu Ser Leu Ala Leu Ala Asp Gly Ser Gln Glu 
        35                  40                  45              


Gln Glu Pro Glu Glu Glu Ile Ala Met Glu Asp Ser Pro Thr Met Val 
    50                  55                  60                  


Arg Val Asp Ser Pro Thr Met Val Arg Gly Glu Asn Gln Val Ser Pro 
65                  70                  75                  80  


Cys Gln Gly Arg Arg Cys Phe Pro Lys Ala Leu Gly Tyr Val Thr Gly 
                85                  90                  95      


Asp Met Lys Glu Leu Ala Asn Gln Leu Lys Asp Lys Pro Val Val Leu 
            100                 105                 110         


Gln Phe Ile Asp Trp Ile Leu Arg Gly Ile Ser Gln Val Val Phe Val 
        115                 120                 125             


Asn Asn Pro Val Ser Gly Ile Leu Ile Leu Val Gly Leu Leu Val Gln 
    130                 135                 140                 


Asn Pro Trp Trp Ala Leu Thr Gly Trp Leu Gly Thr Val Val Ser Thr 
145                 150                 155                 160 


Leu Met Ala Leu Leu Leu Ser Gln Asp Arg Ser Leu Ile Ala Ser Gly 
                165                 170                 175     


Leu Tyr Gly Tyr Asn Ala Thr Leu Val Gly Val Leu Met Ala Val Phe 
            180                 185                 190         


Ser Asp Lys Gly Asp Tyr Phe Trp Trp Leu Leu Leu Pro Val Cys Ala 
        195                 200                 205             


Met Ser Met Thr Cys Pro Ile Phe Ser Ser Ala Leu Asn Ser Met Leu 
    210                 215                 220                 


Ser Lys Trp Asp Leu Pro Val Phe Thr Leu Pro Phe Asn Met Ala Leu 
225                 230                 235                 240 


Ser Met Tyr Leu Ser Ala Thr Gly His Tyr Asn Pro Phe Phe Pro Ala 
                245                 250                 255     


Lys Leu Val Ile Pro Ile Thr Thr Ala Pro Asn Ile Ser Trp Ser Asp 
            260                 265                 270         


Leu Ser Ala Leu Glu Leu Leu Lys Ser Ile Pro Val Gly Val Gly Gln 
        275                 280                 285             


Ile Tyr Gly Cys Asp Asn Pro Trp Thr Gly Gly Ile Phe Leu Gly Ala 
    290                 295                 300                 


Ile Leu Leu Ser Ser Pro Leu Met Cys Leu His Ala Ala Ile Gly Ser 
305                 310                 315                 320 


Leu Leu Gly Ile Ala Ala Gly Leu Ser Leu Ser Ala Pro Phe Glu Asp 
                325                 330                 335     


Ile Tyr Phe Gly Leu Trp Gly Phe Asn Ser Ser Leu Ala Cys Ile Ala 
            340                 345                 350         


Met Gly Gly Met Phe Met Ala Leu Thr Trp Gln Thr His Leu Leu Ala 
        355                 360                 365             


Leu Gly Cys Ala Leu Phe Thr Ala Tyr Leu Gly Val Gly Met Ala Asn 
    370                 375                 380                 


Phe Met Ala Glu Val Gly Leu Pro Ala Cys Thr Trp Pro Phe Cys Leu 
385                 390                 395                 400 


Ala Thr Leu Leu Phe Leu Ile Met Thr Thr Lys Asn Ser Asn Ile Tyr 
                405                 410                 415     


Lys Met Pro Leu Ser Lys Val Thr Tyr Pro Glu Glu Asn Arg Ile Phe 
            420                 425                 430         


Tyr Leu Gln Ala Lys Lys Arg Met Val Glu Ser Pro Leu 
        435                 440                 445 


<210>  9
<211>  201
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SITE
<222>  (1)..(201)
<223>  MSP1

<400>  9

Gly Leu Lys Leu Leu Ser Asn Trp Asp Ser Val Thr Ser Thr Phe Ser 
1               5                   10                  15      


Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn 
            20                  25                  30          


Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu 
        35                  40                  45              


Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys 
    50                  55                  60                  


Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu 
65                  70                  75                  80  


Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln 
                85                  90                  95      


Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala 
            100                 105                 110         


His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu 
        115                 120                 125             


Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly 
    130                 135                 140                 


Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr 
145                 150                 155                 160 


Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu 
                165                 170                 175     


Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu 
            180                 185                 190         


Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
        195                 200     


<210>  10
<211>  211
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SITE
<222>  (1)..(211)
<223>  MSP1D1

<400>  10

Gly His His His His His His His Asp Tyr Asp Ile Pro Thr Thr Glu 
1               5                   10                  15      


Asn Leu Tyr Phe Gln Gly Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu 
            20                  25                  30          


Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu 
        35                  40                  45              


Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys 
    50                  55                  60                  


Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met 
65                  70                  75                  80  


Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu 
                85                  90                  95      


Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu 
            100                 105                 110         


Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg 
        115                 120                 125             


Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala 
    130                 135                 140                 


Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr 
145                 150                 155                 160 


His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys 
                165                 170                 175     


Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser 
            180                 185                 190         


Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu 
        195                 200                 205             


Asn Thr Gln 
    210     


<210>  11
<211>  278
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SITE
<222>  (1)..(278)
<223>  MSP1E3D1

<400>  11

Met Gly His His His His His His His Asp Tyr Asp Ile Pro Thr Thr 
1               5                   10                  15      


Glu Asn Leu Tyr Phe Gln Gly Ser Thr Phe Ser Lys Leu Arg Glu Gln 
            20                  25                  30          


Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr 
        35                  40                  45              


Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala 
    50                  55                  60                  


Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu 
65                  70                  75                  80  


Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln 
                85                  90                  95      


Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro 
            100                 105                 110         


Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu 
        115                 120                 125             


Arg Thr His Leu Ala Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln 
    130                 135                 140                 


Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu 
145                 150                 155                 160 


Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu 
                165                 170                 175     


Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp 
            180                 185                 190         


Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg 
        195                 200                 205             


Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu 
    210                 215                 220                 


Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu 
225                 230                 235                 240 


Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val 
                245                 250                 255     


Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr 
            260                 265                 270         


Lys Lys Leu Asn Thr Gln 
        275             


