                         SEQUENCE LISTING

<110>  INRA
 
<120>  PROCEDE DE CRIBLAGE DE COMPOSES A EFFET ANTI-INFLAMMATOIRE BASE 
       SUR LA PROTEINE DACT3 ET NOUVELLES STRATEGIES THERAPEUTIQUES

<130>  B2119PC

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  2834
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (75)..(1964)

<400>  1
gctggggcgg ggaggtggga ccgggagagg ggtggccgcg gggcccggcc gggctggggc       60

ggggggccgc agcc atg atc cgg gcc ttc tcg ttc ccg gtg agc cct gag        110
                Met Ile Arg Ala Phe Ser Phe Pro Val Ser Pro Glu           
                1               5                   10                    

cgg ggc cgg ctg cgg ggc tgg ctg gag ggt agc ctg gcc ggg ctc tgc        158
Arg Gly Arg Leu Arg Gly Trp Leu Glu Gly Ser Leu Ala Gly Leu Cys           
        15                  20                  25                        

gag tta cat tgg ctc cgg gag agg cag gag tac cgc gtg cag cag gcg        206
Glu Leu His Trp Leu Arg Glu Arg Gln Glu Tyr Arg Val Gln Gln Ala           
    30                  35                  40                            

ctg cgg ctg gcc cag ccc gga atg ggg ggc gcc gag gcc gag gac gag        254
Leu Arg Leu Ala Gln Pro Gly Met Gly Gly Ala Glu Ala Glu Asp Glu           
45                  50                  55                  60            

gag gac gcc gat gag gat gaa gat gcg gcg gcg gcg cgc cgg gcc gca        302
Glu Asp Ala Asp Glu Asp Glu Asp Ala Ala Ala Ala Arg Arg Ala Ala           
                65                  70                  75                

gcg gcc ctg gag gag cag ctg gag gcc ctg cct ggt ctc gtc tgg gac        350
Ala Ala Leu Glu Glu Gln Leu Glu Ala Leu Pro Gly Leu Val Trp Asp           
            80                  85                  90                    

ctg gga cag cag ctg gga gac ctg agc ctg gag tct ggg ggc ctg gaa        398
Leu Gly Gln Gln Leu Gly Asp Leu Ser Leu Glu Ser Gly Gly Leu Glu           
        95                  100                 105                       

cag gag agc ggg cgt agc tcg ggc ttc tat gaa gat ccc agc tct aca        446
Gln Glu Ser Gly Arg Ser Ser Gly Phe Tyr Glu Asp Pro Ser Ser Thr           
    110                 115                 120                           

gga ggt cca gat tca cca ccc tca acc ttc tgt ggg gac agt ggc ttc        494
Gly Gly Pro Asp Ser Pro Pro Ser Thr Phe Cys Gly Asp Ser Gly Phe           
125                 130                 135                 140           

tct gga tcc agc tcc tat ggt cgc ctg ggt ccc tct gag ccc cgg ggc        542
Ser Gly Ser Ser Ser Tyr Gly Arg Leu Gly Pro Ser Glu Pro Arg Gly           
                145                 150                 155               

atc tat gcc agt gag agg ccc aag tcc cta gga gac gcc agt ccc agc        590
Ile Tyr Ala Ser Glu Arg Pro Lys Ser Leu Gly Asp Ala Ser Pro Ser           
            160                 165                 170                   

gct ccg gag gtg gtg ggc gcg cgg gca gcg gtg ccg cgg tcc ttc tca        638
Ala Pro Glu Val Val Gly Ala Arg Ala Ala Val Pro Arg Ser Phe Ser           
        175                 180                 185                       

gcg ccc tac ccg acg gca ggg ggg tcc gcc ggc ccg gag gcc tgc tcc        686
Ala Pro Tyr Pro Thr Ala Gly Gly Ser Ala Gly Pro Glu Ala Cys Ser           
    190                 195                 200                           

tcg gcg gag cgg cgg gcc cgc gcc ggg ccc ttt ctg acg ccc agc ccc        734
Ser Ala Glu Arg Arg Ala Arg Ala Gly Pro Phe Leu Thr Pro Ser Pro           
205                 210                 215                 220           

ctg cac gcc gtg gcg atg cgc agc ccg cgg ccc tgc ggc cgc cct ccc        782
Leu His Ala Val Ala Met Arg Ser Pro Arg Pro Cys Gly Arg Pro Pro           
                225                 230                 235               

acc gac tcg ccc gac gcg ggg ggc gca ggg cgg ccc ctg gac ggc tac        830
Thr Asp Ser Pro Asp Ala Gly Gly Ala Gly Arg Pro Leu Asp Gly Tyr           
            240                 245                 250                   

atc tcg gcg ctc ctg cgc agg cgc cgc cgc cgg ggg gcg ggc cag ccc        878
Ile Ser Ala Leu Leu Arg Arg Arg Arg Arg Arg Gly Ala Gly Gln Pro           
        255                 260                 265                       

cgg acc agt ccc ggg ggc gcg gac ggc ggc ccg cgg cgc cag aac agc        926
Arg Thr Ser Pro Gly Gly Ala Asp Gly Gly Pro Arg Arg Gln Asn Ser           
    270                 275                 280                           

gtg cgc cag cgg ccg ccc gac gcg tct ccg tcc ccc ggc agc gcg cga        974
Val Arg Gln Arg Pro Pro Asp Ala Ser Pro Ser Pro Gly Ser Ala Arg           
285                 290                 295                 300           

ccc gcg cgg gag ccc tcg ttg gag cgc gtc ggg ggc cac ccc acc agc       1022
Pro Ala Arg Glu Pro Ser Leu Glu Arg Val Gly Gly His Pro Thr Ser           
                305                 310                 315               

cct gcc gcc ttg agc cgc gcc tgg gcg tcg tcg tgg gag tcg gag gcg       1070
Pro Ala Ala Leu Ser Arg Ala Trp Ala Ser Ser Trp Glu Ser Glu Ala           
            320                 325                 330                   

gca ccc gag ccc gct gcg ccg ccc gcc gcc ccc tca ccc ccc gac agc       1118
Ala Pro Glu Pro Ala Ala Pro Pro Ala Ala Pro Ser Pro Pro Asp Ser           
        335                 340                 345                       

ccg gct gag ggc cgc ttg gtg aag gcg cag tac atc ccg ggc gcg cag       1166
Pro Ala Glu Gly Arg Leu Val Lys Ala Gln Tyr Ile Pro Gly Ala Gln           
    350                 355                 360                           

gcg gcc acc cga ggc ctc cct ggc cgc gcc gcc cgc cgc aaa ccg ccg       1214
Ala Ala Thr Arg Gly Leu Pro Gly Arg Ala Ala Arg Arg Lys Pro Pro           
365                 370                 375                 380           

cca ctg acc cgc ggc cgc agc gtg gag cag tca cca ccc cgg gag cgt       1262
Pro Leu Thr Arg Gly Arg Ser Val Glu Gln Ser Pro Pro Arg Glu Arg           
                385                 390                 395               

ccc cgg gcc gcc ggc cgc cgt gga cgc atg gcc gag gct tcg ggc cgc       1310
Pro Arg Ala Ala Gly Arg Arg Gly Arg Met Ala Glu Ala Ser Gly Arg           
            400                 405                 410                   

cgc ggc tcg ccc agg gcc cgc aag gcc tcg cgc tcc cag tct gag acc       1358
Arg Gly Ser Pro Arg Ala Arg Lys Ala Ser Arg Ser Gln Ser Glu Thr           
        415                 420                 425                       

agc ctg ctg ggc cgc gcc tcc gcg gtc cct tcg ggg ccc cct aag tac       1406
Ser Leu Leu Gly Arg Ala Ser Ala Val Pro Ser Gly Pro Pro Lys Tyr           
    430                 435                 440                           

ccc acg gcg gag cgg gaa gag cct cgg cct cca cgg cca cgc cgc ggc       1454
Pro Thr Ala Glu Arg Glu Glu Pro Arg Pro Pro Arg Pro Arg Arg Gly           
445                 450                 455                 460           

cca gcg ccc acg ctg gcg gcc cag gcc gca ggg tcc tgc cgt cgc tgg       1502
Pro Ala Pro Thr Leu Ala Ala Gln Ala Ala Gly Ser Cys Arg Arg Trp           
                465                 470                 475               

cgc tcc act gcg gag atc gac gct gcc gat ggg cgc cgc gtg cgg ccc       1550
Arg Ser Thr Ala Glu Ile Asp Ala Ala Asp Gly Arg Arg Val Arg Pro           
            480                 485                 490                   

cga gcc cct gcg gcg cgt gtt ccc ggc ccc ggc ccg tcc ccg tca gct       1598
Arg Ala Pro Ala Ala Arg Val Pro Gly Pro Gly Pro Ser Pro Ser Ala           
        495                 500                 505                       

ccc cag cgt cgt ctg ctt tac ggc tgc gcg ggc agc gac tcc gag tgc       1646
Pro Gln Arg Arg Leu Leu Tyr Gly Cys Ala Gly Ser Asp Ser Glu Cys           
    510                 515                 520                           

tcg gct ggg cgc ctg ggg ccc ctg gga cgc cgg ggg cct gcg gga ggc       1694
Ser Ala Gly Arg Leu Gly Pro Leu Gly Arg Arg Gly Pro Ala Gly Gly           
525                 530                 535                 540           

gtc ggc ggg ggt tac ggg gag agc gaa tcg agc gcc agc gag gga gaa       1742
Val Gly Gly Gly Tyr Gly Glu Ser Glu Ser Ser Ala Ser Glu Gly Glu           
                545                 550                 555               

tcg cct gcc ttc agc tct gcc tcc agc gac tca gac ggc agc ggt ggc       1790
Ser Pro Ala Phe Ser Ser Ala Ser Ser Asp Ser Asp Gly Ser Gly Gly           
            560                 565                 570                   

ctc gtg tgg ccg cag cag ctg gtg gcg gcc acc gcg gcc tct ggg ggt       1838
Leu Val Trp Pro Gln Gln Leu Val Ala Ala Thr Ala Ala Ser Gly Gly           
        575                 580                 585                       

gga gca ggt gca ggg gcg ccc gca ggc ccc gcc aaa gtc ttc gtg aaa       1886
Gly Ala Gly Ala Gly Ala Pro Ala Gly Pro Ala Lys Val Phe Val Lys           
    590                 595                 600                           

atc aaa gct tcc cac gcg ctc aag aaa aag ata ctg cgt ttc cgt tcg       1934
Ile Lys Ala Ser His Ala Leu Lys Lys Lys Ile Leu Arg Phe Arg Ser           
605                 610                 615                 620           

ggt tct ctc aag gtc atg act aca gtg tga gtttggggat ttgcttgggc         1984
Gly Ser Leu Lys Val Met Thr Thr Val                                       
                625                                                       

tcccccttca tggcctctgc acctccacac tcccaaccac tgacccttcc acatctacct     2044

tccaaagacc atcgttttct ctgcttccaa agacccccct cactctcccc actcctaaca     2104

gtcttggttg aaaaggctcc cccaccacca ccgagaggaa tggggaggag ccctgtttga     2164

cccagttcag cttctagctt ggaagccctt gggcaagaca gttccccttc tctgggcgtc     2224

actttcctca tctgtacagt aagtgtccat gtatgcaaaa ggggtaattc ggtttgaatt     2284

tccccgtttt agtttagaag cctagtctgt ttgttcccct ccaccgctct ccctctcatt     2344

cctgatgagc cctctcattc ctcctttcct tgcccagcta tggccccctc tcattcacaa     2404

agtgccccct ccatgtccct ggacccttaa gatatcccct tggcaccctg gtcagagact     2464

ctgtgtctga ctcaggtggt ccctgcagag tgccctggga agggaaggag cactgatttg     2524

ggggttttga gggtcaagta ggggttggta acacctggaa agaaggactc tttcacttcg     2584

atccctggac aattatggag gattcggagg tagaagaggg gaaggaagat ggtttctatc     2644

tcatgacccc cactccctgt gagagggaat gggggaagcc tgatgaccct cagctgttcc     2704

aatctagtat tttttttctt ttttaaaatt actgtattta ttatgacgat ggtgactccc     2764

cagtgcaaag gggggccaga ttctgtgtgt ttctctaacc tctttgtaaa taaatgcaca     2824

gtgtaacata                                                            2834


<210>  2
<211>  629
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ile Arg Ala Phe Ser Phe Pro Val Ser Pro Glu Arg Gly Arg Leu 
1               5                   10                  15      


Arg Gly Trp Leu Glu Gly Ser Leu Ala Gly Leu Cys Glu Leu His Trp 
            20                  25                  30          


Leu Arg Glu Arg Gln Glu Tyr Arg Val Gln Gln Ala Leu Arg Leu Ala 
        35                  40                  45              


Gln Pro Gly Met Gly Gly Ala Glu Ala Glu Asp Glu Glu Asp Ala Asp 
    50                  55                  60                  


Glu Asp Glu Asp Ala Ala Ala Ala Arg Arg Ala Ala Ala Ala Leu Glu 
65                  70                  75                  80  


Glu Gln Leu Glu Ala Leu Pro Gly Leu Val Trp Asp Leu Gly Gln Gln 
                85                  90                  95      


Leu Gly Asp Leu Ser Leu Glu Ser Gly Gly Leu Glu Gln Glu Ser Gly 
            100                 105                 110         


Arg Ser Ser Gly Phe Tyr Glu Asp Pro Ser Ser Thr Gly Gly Pro Asp 
        115                 120                 125             


Ser Pro Pro Ser Thr Phe Cys Gly Asp Ser Gly Phe Ser Gly Ser Ser 
    130                 135                 140                 


Ser Tyr Gly Arg Leu Gly Pro Ser Glu Pro Arg Gly Ile Tyr Ala Ser 
145                 150                 155                 160 


Glu Arg Pro Lys Ser Leu Gly Asp Ala Ser Pro Ser Ala Pro Glu Val 
                165                 170                 175     


Val Gly Ala Arg Ala Ala Val Pro Arg Ser Phe Ser Ala Pro Tyr Pro 
            180                 185                 190         


Thr Ala Gly Gly Ser Ala Gly Pro Glu Ala Cys Ser Ser Ala Glu Arg 
        195                 200                 205             


Arg Ala Arg Ala Gly Pro Phe Leu Thr Pro Ser Pro Leu His Ala Val 
    210                 215                 220                 


Ala Met Arg Ser Pro Arg Pro Cys Gly Arg Pro Pro Thr Asp Ser Pro 
225                 230                 235                 240 


Asp Ala Gly Gly Ala Gly Arg Pro Leu Asp Gly Tyr Ile Ser Ala Leu 
                245                 250                 255     


Leu Arg Arg Arg Arg Arg Arg Gly Ala Gly Gln Pro Arg Thr Ser Pro 
            260                 265                 270         


Gly Gly Ala Asp Gly Gly Pro Arg Arg Gln Asn Ser Val Arg Gln Arg 
        275                 280                 285             


Pro Pro Asp Ala Ser Pro Ser Pro Gly Ser Ala Arg Pro Ala Arg Glu 
    290                 295                 300                 


Pro Ser Leu Glu Arg Val Gly Gly His Pro Thr Ser Pro Ala Ala Leu 
305                 310                 315                 320 


Ser Arg Ala Trp Ala Ser Ser Trp Glu Ser Glu Ala Ala Pro Glu Pro 
                325                 330                 335     


Ala Ala Pro Pro Ala Ala Pro Ser Pro Pro Asp Ser Pro Ala Glu Gly 
            340                 345                 350         


Arg Leu Val Lys Ala Gln Tyr Ile Pro Gly Ala Gln Ala Ala Thr Arg 
        355                 360                 365             


Gly Leu Pro Gly Arg Ala Ala Arg Arg Lys Pro Pro Pro Leu Thr Arg 
    370                 375                 380                 


Gly Arg Ser Val Glu Gln Ser Pro Pro Arg Glu Arg Pro Arg Ala Ala 
385                 390                 395                 400 


Gly Arg Arg Gly Arg Met Ala Glu Ala Ser Gly Arg Arg Gly Ser Pro 
                405                 410                 415     


Arg Ala Arg Lys Ala Ser Arg Ser Gln Ser Glu Thr Ser Leu Leu Gly 
            420                 425                 430         


Arg Ala Ser Ala Val Pro Ser Gly Pro Pro Lys Tyr Pro Thr Ala Glu 
        435                 440                 445             


Arg Glu Glu Pro Arg Pro Pro Arg Pro Arg Arg Gly Pro Ala Pro Thr 
    450                 455                 460                 


Leu Ala Ala Gln Ala Ala Gly Ser Cys Arg Arg Trp Arg Ser Thr Ala 
465                 470                 475                 480 


Glu Ile Asp Ala Ala Asp Gly Arg Arg Val Arg Pro Arg Ala Pro Ala 
                485                 490                 495     


Ala Arg Val Pro Gly Pro Gly Pro Ser Pro Ser Ala Pro Gln Arg Arg 
            500                 505                 510         


Leu Leu Tyr Gly Cys Ala Gly Ser Asp Ser Glu Cys Ser Ala Gly Arg 
        515                 520                 525             


Leu Gly Pro Leu Gly Arg Arg Gly Pro Ala Gly Gly Val Gly Gly Gly 
    530                 535                 540                 


Tyr Gly Glu Ser Glu Ser Ser Ala Ser Glu Gly Glu Ser Pro Ala Phe 
545                 550                 555                 560 


Ser Ser Ala Ser Ser Asp Ser Asp Gly Ser Gly Gly Leu Val Trp Pro 
                565                 570                 575     


Gln Gln Leu Val Ala Ala Thr Ala Ala Ser Gly Gly Gly Ala Gly Ala 
            580                 585                 590         


Gly Ala Pro Ala Gly Pro Ala Lys Val Phe Val Lys Ile Lys Ala Ser 
        595                 600                 605             


His Ala Leu Lys Lys Lys Ile Leu Arg Phe Arg Ser Gly Ser Leu Lys 
    610                 615                 620                 


Val Met Thr Thr Val 
625                 


<210>  3
<211>  2581
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (442)..(1656)

<400>  3
ctcactcaga cccatgaggc cctgcctggt ctcgtctggg acctgggaca gcagctggga       60

gacctgagcc tggagtctgg gggcctggaa caggagagcg ggcgtagctc gggcttctat      120

gaagatccca gctctacagg aggtccagat tcaccaccct caaccttctg tggggacagt      180

ggcttctctg gatccagctc ctatggtcgc ctgggtccct ctgagccccg gggcatctat      240

gccagtgaga ggcccaagtc cctaggagac gccagtccca gcgctccgga ggtggtgggc      300

gcgcgggcag cggtgccgcg gtccttctca gcgccctacc cgacggcagg ggggtccgcc      360

ggcccggagg cctgctcctc ggcggagcgg cgggcccgcg ccgggccctt tctgacgccc      420

agccccctgc acgccgtggc g atg cgc agc ccg cgg ccc tgc ggc cgc cct        471
                        Met Arg Ser Pro Arg Pro Cys Gly Arg Pro           
                        1               5                   10            

ccc acc gac tcg ccc gac gcg ggg ggc gca ggg cgg ccc ctg gac ggc        519
Pro Thr Asp Ser Pro Asp Ala Gly Gly Ala Gly Arg Pro Leu Asp Gly           
                15                  20                  25                

tac atc tcg gcg ctc ctg cgc agg cgc cgc cgc cgg ggg gcg ggc cag        567
Tyr Ile Ser Ala Leu Leu Arg Arg Arg Arg Arg Arg Gly Ala Gly Gln           
            30                  35                  40                    

ccc cgg acc agt ccc ggg ggc gcg gac ggc ggc ccg cgg cgc cag aac        615
Pro Arg Thr Ser Pro Gly Gly Ala Asp Gly Gly Pro Arg Arg Gln Asn           
        45                  50                  55                        

agc gtg cgc cag cgg ccg ccc gac gcg tct ccg tcc ccc ggc agc gcg        663
Ser Val Arg Gln Arg Pro Pro Asp Ala Ser Pro Ser Pro Gly Ser Ala           
    60                  65                  70                            

cga ccc gcg cgg gag ccc tcg ttg gag cgc gtc ggg ggc cac ccc acc        711
Arg Pro Ala Arg Glu Pro Ser Leu Glu Arg Val Gly Gly His Pro Thr           
75                  80                  85                  90            

agc cct gcc gcc ttg agc cgc gcc tgg gcg tcg tcg tgg gag tcg gag        759
Ser Pro Ala Ala Leu Ser Arg Ala Trp Ala Ser Ser Trp Glu Ser Glu           
                95                  100                 105               

gcg gca ccc gag ccc gct gcg ccg ccc gcc gcc ccc tca ccc ccc gac        807
Ala Ala Pro Glu Pro Ala Ala Pro Pro Ala Ala Pro Ser Pro Pro Asp           
            110                 115                 120                   

agc ccg gct gag ggc cgc ttg gtg aag gcg cag tac atc ccg ggc gcg        855
Ser Pro Ala Glu Gly Arg Leu Val Lys Ala Gln Tyr Ile Pro Gly Ala           
        125                 130                 135                       

cag gcg gcc acc cga ggc ctc cct ggc cgc gcc gcc cgc cgc aaa ccg        903
Gln Ala Ala Thr Arg Gly Leu Pro Gly Arg Ala Ala Arg Arg Lys Pro           
    140                 145                 150                           

ccg cca ctg acc cgc ggc cgc agc gtg gag cag tca cca ccc cgg gag        951
Pro Pro Leu Thr Arg Gly Arg Ser Val Glu Gln Ser Pro Pro Arg Glu           
155                 160                 165                 170           

cgt ccc cgg gcc gcc ggc cgc cgt gga cgc atg gcc gag gct tcg ggc        999
Arg Pro Arg Ala Ala Gly Arg Arg Gly Arg Met Ala Glu Ala Ser Gly           
                175                 180                 185               

cgc cgc ggc tcg ccc agg gcc cgc aag gcc tcg cgc tcc cag tct gag       1047
Arg Arg Gly Ser Pro Arg Ala Arg Lys Ala Ser Arg Ser Gln Ser Glu           
            190                 195                 200                   

acc agc ctg ctg ggc cgc gcc tcc gcg gtc cct tcg ggg ccc cct aag       1095
Thr Ser Leu Leu Gly Arg Ala Ser Ala Val Pro Ser Gly Pro Pro Lys           
        205                 210                 215                       

tac ccc acg gcg gag cgg gaa gag cct cgg cct cca cgg cca cgc cgc       1143
Tyr Pro Thr Ala Glu Arg Glu Glu Pro Arg Pro Pro Arg Pro Arg Arg           
    220                 225                 230                           

ggc cca gcg ccc acg ctg gcg gcc cag gcc gca ggg tcc tgc cgt cgc       1191
Gly Pro Ala Pro Thr Leu Ala Ala Gln Ala Ala Gly Ser Cys Arg Arg           
235                 240                 245                 250           

tgg cgc tcc act gcg gag atc gac gct gcc gat ggg cgc cgc gtg cgg       1239
Trp Arg Ser Thr Ala Glu Ile Asp Ala Ala Asp Gly Arg Arg Val Arg           
                255                 260                 265               

ccc cga gcc cct gcg gcg cgt gtt ccc ggc ccc ggc ccg tcc ccg tca       1287
Pro Arg Ala Pro Ala Ala Arg Val Pro Gly Pro Gly Pro Ser Pro Ser           
            270                 275                 280                   

gct ccc cag cgt cgt ctg ctt tac ggc tgc gcg ggc agc gac tcc gag       1335
Ala Pro Gln Arg Arg Leu Leu Tyr Gly Cys Ala Gly Ser Asp Ser Glu           
        285                 290                 295                       

tgc tcg gct ggg cgc ctg ggg ccc ctg gga cgc cgg ggg cct gcg gga       1383
Cys Ser Ala Gly Arg Leu Gly Pro Leu Gly Arg Arg Gly Pro Ala Gly           
    300                 305                 310                           

ggc gtc ggc ggg ggt tac ggg gag agc gaa tcg agc gcc agc gag gga       1431
Gly Val Gly Gly Gly Tyr Gly Glu Ser Glu Ser Ser Ala Ser Glu Gly           
315                 320                 325                 330           

gaa tcg cct gcc ttc agc tct gcc tcc agc gac tca gac ggc agc ggt       1479
Glu Ser Pro Ala Phe Ser Ser Ala Ser Ser Asp Ser Asp Gly Ser Gly           
                335                 340                 345               

ggc ctc gtg tgg ccg cag cag ctg gtg gcg gcc acc gcg gcc tct ggg       1527
Gly Leu Val Trp Pro Gln Gln Leu Val Ala Ala Thr Ala Ala Ser Gly           
            350                 355                 360                   

ggt gga gca ggt gca ggg gcg ccc gca ggc ccc gcc aaa gtc ttc gtg       1575
Gly Gly Ala Gly Ala Gly Ala Pro Ala Gly Pro Ala Lys Val Phe Val           
        365                 370                 375                       

aaa atc aaa gct tcc cac gcg ctc aag aaa aag ata ctg cgt ttc cgt       1623
Lys Ile Lys Ala Ser His Ala Leu Lys Lys Lys Ile Leu Arg Phe Arg           
    380                 385                 390                           

tcg ggt tct ctc aag gtc atg act aca gtg tga gtttggggat ttgcttgggc     1676
Ser Gly Ser Leu Lys Val Met Thr Thr Val                                   
395                 400                                                   

tcccccttca tggcctctgc acctccacac tcccaaccac tgacccttcc acatctacct     1736

tccaaagacc atcgttttct ctgcttccaa agacccccct cactctcccc actcctaaca     1796

gtcttggttg aaaaggctcc cccaccacca ccgagaggaa tggggaggag ccctgtttga     1856

cccagttcag cttctagctt ggaagccctt gggcaagaca gttccccttc tctgggcgtc     1916

actttcctca tctgtacagt aagtgtccat gtatgcaaaa ggggtaattc ggtttgaatt     1976

tccccgtttt agtttagaag cctagtctgt ttgttcccct ccaccgctct ccctctcatt     2036

cctgatgagc cctctcattc ctcctttcct tgcccagcta tggccccctc tcattcacaa     2096

agtgccccct ccatgtccct ggacccttaa gatatcccct tggcaccctg gtcagagact     2156

ctgtgtctga ctcaggtggt ccctgcagag tgccctggga agggaaggag cactgatttg     2216

ggggttttga gggtcaagta ggggttggta acacctggaa agaaggactc tttcacttcg     2276

atccctggac aattatggag gattcggagg tagaagaggg gaaggaagat ggtttctatc     2336

tcatgacccc cactccctgt gagagggaat gggggaagcc tgatgaccct cagctgttcc     2396

aatctagtat tttttttctt ttttaaaatt actgtattta ttatgacgat ggtgactccc     2456

cagtgcaaag gggggccaga ttctgtgtgt ttctctaacc tctttgtaaa taaatgcaca     2516

gtgtaacata tgtggtggac tctcactgaa tgattaaatg ggagaaatgc tctttttcaa     2576

aaaaa                                                                 2581


<210>  4
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Ser Pro Arg Pro Cys Gly Arg Pro Pro Thr Asp Ser Pro Asp 
1               5                   10                  15      


Ala Gly Gly Ala Gly Arg Pro Leu Asp Gly Tyr Ile Ser Ala Leu Leu 
            20                  25                  30          


Arg Arg Arg Arg Arg Arg Gly Ala Gly Gln Pro Arg Thr Ser Pro Gly 
        35                  40                  45              


Gly Ala Asp Gly Gly Pro Arg Arg Gln Asn Ser Val Arg Gln Arg Pro 
    50                  55                  60                  


Pro Asp Ala Ser Pro Ser Pro Gly Ser Ala Arg Pro Ala Arg Glu Pro 
65                  70                  75                  80  


Ser Leu Glu Arg Val Gly Gly His Pro Thr Ser Pro Ala Ala Leu Ser 
                85                  90                  95      


Arg Ala Trp Ala Ser Ser Trp Glu Ser Glu Ala Ala Pro Glu Pro Ala 
            100                 105                 110         


Ala Pro Pro Ala Ala Pro Ser Pro Pro Asp Ser Pro Ala Glu Gly Arg 
        115                 120                 125             


Leu Val Lys Ala Gln Tyr Ile Pro Gly Ala Gln Ala Ala Thr Arg Gly 
    130                 135                 140                 


Leu Pro Gly Arg Ala Ala Arg Arg Lys Pro Pro Pro Leu Thr Arg Gly 
145                 150                 155                 160 


Arg Ser Val Glu Gln Ser Pro Pro Arg Glu Arg Pro Arg Ala Ala Gly 
                165                 170                 175     


Arg Arg Gly Arg Met Ala Glu Ala Ser Gly Arg Arg Gly Ser Pro Arg 
            180                 185                 190         


Ala Arg Lys Ala Ser Arg Ser Gln Ser Glu Thr Ser Leu Leu Gly Arg 
        195                 200                 205             


Ala Ser Ala Val Pro Ser Gly Pro Pro Lys Tyr Pro Thr Ala Glu Arg 
    210                 215                 220                 


Glu Glu Pro Arg Pro Pro Arg Pro Arg Arg Gly Pro Ala Pro Thr Leu 
225                 230                 235                 240 


Ala Ala Gln Ala Ala Gly Ser Cys Arg Arg Trp Arg Ser Thr Ala Glu 
                245                 250                 255     


Ile Asp Ala Ala Asp Gly Arg Arg Val Arg Pro Arg Ala Pro Ala Ala 
            260                 265                 270         


Arg Val Pro Gly Pro Gly Pro Ser Pro Ser Ala Pro Gln Arg Arg Leu 
        275                 280                 285             


Leu Tyr Gly Cys Ala Gly Ser Asp Ser Glu Cys Ser Ala Gly Arg Leu 
    290                 295                 300                 


Gly Pro Leu Gly Arg Arg Gly Pro Ala Gly Gly Val Gly Gly Gly Tyr 
305                 310                 315                 320 


Gly Glu Ser Glu Ser Ser Ala Ser Glu Gly Glu Ser Pro Ala Phe Ser 
                325                 330                 335     


Ser Ala Ser Ser Asp Ser Asp Gly Ser Gly Gly Leu Val Trp Pro Gln 
            340                 345                 350         


Gln Leu Val Ala Ala Thr Ala Ala Ser Gly Gly Gly Ala Gly Ala Gly 
        355                 360                 365             


Ala Pro Ala Gly Pro Ala Lys Val Phe Val Lys Ile Lys Ala Ser His 
    370                 375                 380                 


Ala Leu Lys Lys Lys Ile Leu Arg Phe Arg Ser Gly Ser Leu Lys Val 
385                 390                 395                 400 


Met Thr Thr Val 
                


<210>  5
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Amorce

<400>  5
gcagatggcc cataccttca                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Amorce

<400>  6
tgctggtccc acatagttgc                                                   20


<210>  7
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Amorce

<400>  7
tctggtatga tccttctgaa gca                                               23


<210>  8
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Amorce

<400>  8
tcctccaagt ccataacttc ctt                                               23


<210>  9
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Amorce

<400>  9
gtgccgaaaa aggaagctgg                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Amorce

<400>  10
ctgcgttagc atgagttggc                                                   20


<210>  11
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  Amorce

<400>  11
gtcaccgagg agcaggagg                                                    19


<210>  12
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Amorce

<400>  12
tcttgtgcag atcgtccagg                                                   20


<210>  13
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  Amorce

<400>  13
tgtctgtggc ttcccttgat ctga                                              24


<210>  14
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  Amorce

<400>  14
tggatgatgc tgggaacagg aagt                                              24


<210>  15
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Amorce

<400>  15
cagagagtcc tgtgctgaat                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Amorce

<400>  16
gtaggagagg tcagagaggc                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Amorce

<400>  17
ggtgcagttt tgccaaggag                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Amorce

<400>  18
ttccttgggg tccagacaga                                                   20


