               SEQUENCE LISTING

<110> Apogenix AG

<120> SINGLE-CHAIN CD137-RECEPTOR AGONIST PROTEINS

<130> scCD137L-WO

<160> 43

<170> BiSSAP 1.3.6

<210> 1
<211> 254
<212> PRT
<213> Homo sapiens


<220> 
<223> CD137 ligand WT

<400> 1
Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      
Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          
Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              
Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  
Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  
Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      
Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         
Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             
Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 
Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 
Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     
Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         
Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             
Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 
Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 
Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 

<210> 2
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 2
Gly Ser Gly Ser Gly Asn Gly Ser 
1               5               

<210> 3
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 3
Gly Ser Gly Ser Gly Ser Gly Ser 
1               5               

<210> 4
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 4
Gly Gly Ser Gly Ser Gly Ser Gly 
1               5               

<210> 5
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 5
Gly Gly Ser Gly Ser Gly 
1               5       

<210> 6
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 6
Gly Gly Ser Gly 
1               

<210> 7
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 7
Gly Gly Ser Gly Asn Gly Ser Gly 
1               5               

<210> 8
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 8
Gly Gly Asn Gly Ser Gly Ser Gly 
1               5               

<210> 9
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 9
Gly Gly Asn Gly Ser Gly 
1               5       

<210> 10
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 10
Gly Ser Gly Ser Gly Ser 
1               5       

<210> 11
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 11
Gly Ser Gly Ser 
1               

<210> 12
<211> 3
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 12
Gly Ser Gly 
1           

<210> 13
<211> 218
<212> PRT
<213> Artificial Sequence


<220> 
<223> IGG1-Fc N297S

<400> 13
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
1               5                   10                  15      
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        35                  40                  45              
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    50                  55                  60                  
Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
65                  70                  75                  80  
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                85                  90                  95      
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            100                 105                 110         
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    130                 135                 140                 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
145                 150                 155                 160 
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                165                 170                 175     
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            180                 185                 190         
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        195                 200                 205             
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215             

<210> 14
<211> 217
<212> PRT
<213> Artificial Sequence


<220> 
<223> IGG1-Fc WT

<400> 14
Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      
Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             
Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         

<210> 15
<211> 745
<212> PRT
<213> Artificial Sequence


<220> 
<223> PROT A (CD137L Deglyco Fc)

<400> 15
Met Glu Thr Asp Thr Leu Leu Val Phe Val Leu Leu Val Trp Val Pro 
1               5                   10                  15      
Ala Gly Asn Gly Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
            20                  25                  30          
Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
        35                  40                  45              
Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
    50                  55                  60                  
Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
65                  70                  75                  80  
Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
                85                  90                  95      
Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
            100                 105                 110         
Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
        115                 120                 125             
Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
    130                 135                 140                 
Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
145                 150                 155                 160 
Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser 
                165                 170                 175     
Gly Asn Gly Ser Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
            180                 185                 190         
Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
        195                 200                 205             
Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
    210                 215                 220                 
Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
225                 230                 235                 240 
Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
                245                 250                 255     
Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
            260                 265                 270         
Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
        275                 280                 285             
Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
    290                 295                 300                 
Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
305                 310                 315                 320 
Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser 
                325                 330                 335     
Gly Asn Gly Ser Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
            340                 345                 350         
Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
        355                 360                 365             
Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
    370                 375                 380                 
Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
385                 390                 395                 400 
Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
                405                 410                 415     
Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
            420                 425                 430         
Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
        435                 440                 445             
Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
    450                 455                 460                 
Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
465                 470                 475                 480 
Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser Ser Ser 
                485                 490                 495     
Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            500                 505                 510         
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        515                 520                 525             
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    530                 535                 540                 
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
545                 550                 555                 560 
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                565                 570                 575     
Glu Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            580                 585                 590         
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        595                 600                 605             
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    610                 615                 620                 
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
625                 630                 635                 640 
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                645                 650                 655     
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            660                 665                 670         
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        675                 680                 685             
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    690                 695                 700                 
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
705                 710                 715                 720 
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Ser Ser Ser Ser Ser 
                725                 730                 735     
Ala Trp Ser His Pro Gln Phe Glu Lys 
            740                 745 

<210> 16
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> hinge linker

<400> 16
Gly Ser Ser Ser Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His 
1               5                   10                  15      
Thr Cys Pro Pro Cys 
            20      

<210> 17
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> universal signal peptide

<400> 17
Met Glu Thr Asp Thr Leu Leu Val Phe Val Leu Leu Val Trp Val Pro 
1               5                   10                  15      
Ala Gly Asn Gly 
            20  

<210> 18
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> serine linker with strep tag

<400> 18
Ser Ser Ser Ser Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
1               5                   10                  15  

<210> 19
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> hinge linker

<400> 19
Gly Ser Ser Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr 
1               5                   10                  15      
Cys Pro Pro Cys 
            20  

<210> 20
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> hinge linker

<400> 20
Gly Ser Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys 
1               5                   10                  15      
Pro Pro Cys 
            

<210> 21
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> hinge linker

<400> 21
Gly Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10                  15      
Pro Cys 
        

<210> 22
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> hinge linker

<400> 22
Gly Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      



<210> 23
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> hinge linker

<400> 23
Gly Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      
Gly Ser 
        

<210> 24
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> hinge linker

<400> 24
Gly Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      
Gly Ser Gly Ser 
            20  

<210> 25
<211> 731
<212> PRT
<213> Artificial Sequence


<220> 
<223> PROTEIN A - no strep tag

<400> 25
Met Glu Thr Asp Thr Leu Leu Val Phe Val Leu Leu Val Trp Val Pro 
1               5                   10                  15      
Ala Gly Asn Gly Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
            20                  25                  30          
Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
        35                  40                  45              
Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
    50                  55                  60                  
Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
65                  70                  75                  80  
Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
                85                  90                  95      
Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
            100                 105                 110         
Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
        115                 120                 125             
Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
    130                 135                 140                 
Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
145                 150                 155                 160 
Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser 
                165                 170                 175     
Gly Asn Gly Ser Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
            180                 185                 190         
Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
        195                 200                 205             
Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
    210                 215                 220                 
Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
225                 230                 235                 240 
Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
                245                 250                 255     
Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
            260                 265                 270         
Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
        275                 280                 285             
Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
    290                 295                 300                 
Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
305                 310                 315                 320 
Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser 
                325                 330                 335     
Gly Asn Gly Ser Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
            340                 345                 350         
Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
        355                 360                 365             
Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
    370                 375                 380                 
Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
385                 390                 395                 400 
Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
                405                 410                 415     
Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
            420                 425                 430         
Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
        435                 440                 445             
Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
    450                 455                 460                 
Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
465                 470                 475                 480 
Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser Ser Ser 
                485                 490                 495     
Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            500                 505                 510         
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        515                 520                 525             
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    530                 535                 540                 
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
545                 550                 555                 560 
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                565                 570                 575     
Glu Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            580                 585                 590         
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        595                 600                 605             
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    610                 615                 620                 
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
625                 630                 635                 640 
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                645                 650                 655     
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            660                 665                 670         
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        675                 680                 685             
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    690                 695                 700                 
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
705                 710                 715                 720 
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                725                 730     

<210> 26
<211> 730
<212> PRT
<213> Artificial Sequence


<220> 
<223> CD137L-wt fused to Seq_14

<400> 26
Met Glu Thr Asp Thr Leu Leu Val Phe Val Leu Leu Val Trp Val Pro 
1               5                   10                  15      
Ala Gly Asn Gly Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
            20                  25                  30          
Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
        35                  40                  45              
Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
    50                  55                  60                  
Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
65                  70                  75                  80  
Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
                85                  90                  95      
Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
            100                 105                 110         
Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
        115                 120                 125             
Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
    130                 135                 140                 
Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
145                 150                 155                 160 
Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser 
                165                 170                 175     
Gly Asn Gly Ser Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
            180                 185                 190         
Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
        195                 200                 205             
Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
    210                 215                 220                 
Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
225                 230                 235                 240 
Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
                245                 250                 255     
Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
            260                 265                 270         
Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
        275                 280                 285             
Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
    290                 295                 300                 
Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
305                 310                 315                 320 
Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser 
                325                 330                 335     
Gly Asn Gly Ser Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
            340                 345                 350         
Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
        355                 360                 365             
Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
    370                 375                 380                 
Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
385                 390                 395                 400 
Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
                405                 410                 415     
Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
            420                 425                 430         
Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
        435                 440                 445             
Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
    450                 455                 460                 
Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
465                 470                 475                 480 
Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser Ser Ser 
                485                 490                 495     
Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            500                 505                 510         
Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
        515                 520                 525             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    530                 535                 540                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
545                 550                 555                 560 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                565                 570                 575     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            580                 585                 590         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        595                 600                 605             
Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    610                 615                 620                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
625                 630                 635                 640 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                645                 650                 655     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            660                 665                 670         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        675                 680                 685             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    690                 695                 700                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
705                 710                 715                 720 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                725                 730 

<210> 27
<211> 711
<212> PRT
<213> Artificial Sequence


<220> 
<223> CD137L-wt fused to Seq_13 (no sig, no strep tag, no glyco)

<400> 27
Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
1               5                   10                  15      
Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
            20                  25                  30          
Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
        35                  40                  45              
Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
    50                  55                  60                  
Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
65                  70                  75                  80  
Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                85                  90                  95      
Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
            100                 105                 110         
Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
        115                 120                 125             
His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
    130                 135                 140                 
Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser Gly Asn Gly Ser 
145                 150                 155                 160 
Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
                165                 170                 175     
Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
            180                 185                 190         
Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
        195                 200                 205             
Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
    210                 215                 220                 
Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
225                 230                 235                 240 
Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                245                 250                 255     
Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
            260                 265                 270         
Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
        275                 280                 285             
His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
    290                 295                 300                 
Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser Gly Asn Gly Ser 
305                 310                 315                 320 
Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
                325                 330                 335     
Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
            340                 345                 350         
Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
        355                 360                 365             
Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
    370                 375                 380                 
Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
385                 390                 395                 400 
Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                405                 410                 415     
Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
            420                 425                 430         
Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
        435                 440                 445             
His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
    450                 455                 460                 
Thr Val Leu Gly Leu Phe Arg Val Gly Ser Ser Ser Ser Ser Ser Ser 
465                 470                 475                 480 
Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                485                 490                 495     
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            500                 505                 510         
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        515                 520                 525             
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    530                 535                 540                 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
545                 550                 555                 560 
Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                565                 570                 575     
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            580                 585                 590         
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        595                 600                 605             
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    610                 615                 620                 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
625                 630                 635                 640 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                645                 650                 655     
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            660                 665                 670         
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        675                 680                 685             
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    690                 695                 700                 
Leu Ser Leu Ser Pro Gly Lys 
705                 710     

<210> 28
<211> 725
<212> PRT
<213> Artificial Sequence


<220> 
<223> CD137L-wt fused to Seq_13 (no sig, no glyco)

<400> 28
Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
1               5                   10                  15      
Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
            20                  25                  30          
Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
        35                  40                  45              
Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
    50                  55                  60                  
Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
65                  70                  75                  80  
Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                85                  90                  95      
Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
            100                 105                 110         
Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
        115                 120                 125             
His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
    130                 135                 140                 
Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser Gly Asn Gly Ser 
145                 150                 155                 160 
Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
                165                 170                 175     
Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
            180                 185                 190         
Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
        195                 200                 205             
Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
    210                 215                 220                 
Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
225                 230                 235                 240 
Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                245                 250                 255     
Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
            260                 265                 270         
Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
        275                 280                 285             
His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
    290                 295                 300                 
Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser Gly Asn Gly Ser 
305                 310                 315                 320 
Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
                325                 330                 335     
Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
            340                 345                 350         
Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
        355                 360                 365             
Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
    370                 375                 380                 
Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
385                 390                 395                 400 
Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                405                 410                 415     
Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
            420                 425                 430         
Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
        435                 440                 445             
His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
    450                 455                 460                 
Thr Val Leu Gly Leu Phe Arg Val Gly Ser Ser Ser Ser Ser Ser Ser 
465                 470                 475                 480 
Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                485                 490                 495     
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            500                 505                 510         
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        515                 520                 525             
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    530                 535                 540                 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
545                 550                 555                 560 
Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                565                 570                 575     
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            580                 585                 590         
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        595                 600                 605             
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    610                 615                 620                 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
625                 630                 635                 640 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                645                 650                 655     
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            660                 665                 670         
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        675                 680                 685             
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    690                 695                 700                 
Leu Ser Leu Ser Pro Gly Ser Ser Ser Ser Ser Ser Ala Trp Ser His 
705                 710                 715                 720 
Pro Gln Phe Glu Lys 
                725 

<210> 29
<211> 710
<212> PRT
<213> Artificial Sequence


<220> 
<223> example

<400> 29
Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
1               5                   10                  15      
Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
            20                  25                  30          
Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
        35                  40                  45              
Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
    50                  55                  60                  
Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
65                  70                  75                  80  
Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                85                  90                  95      
Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
            100                 105                 110         
Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
        115                 120                 125             
His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
    130                 135                 140                 
Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser Gly Asn Gly Ser 
145                 150                 155                 160 
Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
                165                 170                 175     
Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
            180                 185                 190         
Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
        195                 200                 205             
Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
    210                 215                 220                 
Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
225                 230                 235                 240 
Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                245                 250                 255     
Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
            260                 265                 270         
Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
        275                 280                 285             
His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
    290                 295                 300                 
Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser Gly Asn Gly Ser 
305                 310                 315                 320 
Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
                325                 330                 335     
Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
            340                 345                 350         
Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
        355                 360                 365             
Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
    370                 375                 380                 
Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
385                 390                 395                 400 
Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                405                 410                 415     
Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
            420                 425                 430         
Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
        435                 440                 445             
His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
    450                 455                 460                 
Thr Val Leu Gly Leu Phe Arg Val Gly Ser Ser Ser Ser Ser Ser Ser 
465                 470                 475                 480 
Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                485                 490                 495     
Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            500                 505                 510         
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        515                 520                 525             
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    530                 535                 540                 
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
545                 550                 555                 560 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                565                 570                 575     
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
            580                 585                 590         
Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        595                 600                 605             
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    610                 615                 620                 
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
625                 630                 635                 640 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                645                 650                 655     
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            660                 665                 670         
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        675                 680                 685             
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    690                 695                 700                 
Ser Leu Ser Pro Gly Lys 
705                 710 

<210> 30
<211> 716
<212> PRT
<213> Artificial Sequence


<220> 
<223> example

<400> 30
Gln Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
1               5                   10                  15      
Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly 
            20                  25                  30          
Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
        35                  40                  45              
Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu 
    50                  55                  60                  
Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
65                  70                  75                  80  
His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 
                85                  90                  95      
Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe 
            100                 105                 110         
Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly 
        115                 120                 125             
Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
    130                 135                 140                 
Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser Gly 
145                 150                 155                 160 
Asn Gly Ser Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln 
                165                 170                 175     
Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly 
            180                 185                 190         
Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr 
        195                 200                 205             
Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln 
    210                 215                 220                 
Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser 
225                 230                 235                 240 
Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala 
                245                 250                 255     
Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn 
            260                 265                 270         
Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln 
        275                 280                 285             
Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp 
    290                 295                 300                 
Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser 
305                 310                 315                 320 
Gly Ser Gly Asn Gly Ser Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
                325                 330                 335     
Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            340                 345                 350         
Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
        355                 360                 365             
Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    370                 375                 380                 
Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
385                 390                 395                 400 
Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                405                 410                 415     
Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            420                 425                 430         
Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        435                 440                 445             
Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    450                 455                 460                 
His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
465                 470                 475                 480 
Val Gly Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro 
                485                 490                 495     
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            500                 505                 510         
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        515                 520                 525             
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    530                 535                 540                 
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
545                 550                 555                 560 
Arg Glu Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                565                 570                 575     
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            580                 585                 590         
Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        595                 600                 605             
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    610                 615                 620                 
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
625                 630                 635                 640 
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                645                 650                 655     
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            660                 665                 670         
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        675                 680                 685             
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    690                 695                 700                 
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
705                 710                 715     

<210> 31
<211> 720
<212> PRT
<213> Artificial Sequence


<220> 
<223> example

<400> 31
Gln Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
1               5                   10                  15      
Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly 
            20                  25                  30          
Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
        35                  40                  45              
Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu 
    50                  55                  60                  
Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
65                  70                  75                  80  
His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 
                85                  90                  95      
Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe 
            100                 105                 110         
Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly 
        115                 120                 125             
Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
    130                 135                 140                 
Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser Gly 
145                 150                 155                 160 
Asn Gly Ser Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln 
                165                 170                 175     
Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly 
            180                 185                 190         
Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr 
        195                 200                 205             
Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln 
    210                 215                 220                 
Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser 
225                 230                 235                 240 
Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala 
                245                 250                 255     
Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn 
            260                 265                 270         
Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln 
        275                 280                 285             
Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp 
    290                 295                 300                 
Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser 
305                 310                 315                 320 
Gly Ser Gly Asn Gly Ser Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
                325                 330                 335     
Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            340                 345                 350         
Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
        355                 360                 365             
Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    370                 375                 380                 
Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
385                 390                 395                 400 
Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                405                 410                 415     
Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            420                 425                 430         
Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        435                 440                 445             
Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    450                 455                 460                 
His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
465                 470                 475                 480 
Val Gly Ser Ser Ser Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr 
                485                 490                 495     
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            500                 505                 510         
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        515                 520                 525             
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    530                 535                 540                 
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
545                 550                 555                 560 
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val 
                565                 570                 575     
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            580                 585                 590         
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        595                 600                 605             
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    610                 615                 620                 
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
625                 630                 635                 640 
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                645                 650                 655     
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            660                 665                 670         
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        675                 680                 685             
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    690                 695                 700                 
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
705                 710                 715                 720 



<210> 32
<211> 711
<212> PRT
<213> Artificial Sequence


<220> 
<223> example

<400> 32
Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
1               5                   10                  15      
Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
            20                  25                  30          
Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
        35                  40                  45              
Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
    50                  55                  60                  
Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
65                  70                  75                  80  
Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
                85                  90                  95      
Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
            100                 105                 110         
Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
        115                 120                 125             
Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
    130                 135                 140                 
Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser Gly Asn Gly 
145                 150                 155                 160 
Ser Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
                165                 170                 175     
Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
            180                 185                 190         
Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
        195                 200                 205             
Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
    210                 215                 220                 
Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
225                 230                 235                 240 
Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
                245                 250                 255     
Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
            260                 265                 270         
Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
        275                 280                 285             
His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
    290                 295                 300                 
Gly Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser Gly Asn 
305                 310                 315                 320 
Gly Ser Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
                325                 330                 335     
Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly 
            340                 345                 350         
Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
        355                 360                 365             
Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu 
    370                 375                 380                 
Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
385                 390                 395                 400 
His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 
                405                 410                 415     
Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe 
            420                 425                 430         
Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly 
        435                 440                 445             
Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
    450                 455                 460                 
Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser Ser Ser Ser 
465                 470                 475                 480 
Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                485                 490                 495     
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            500                 505                 510         
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        515                 520                 525             
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    530                 535                 540                 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
545                 550                 555                 560 
Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                565                 570                 575     
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            580                 585                 590         
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        595                 600                 605             
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    610                 615                 620                 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
625                 630                 635                 640 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                645                 650                 655     
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            660                 665                 670         
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        675                 680                 685             
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    690                 695                 700                 
Leu Ser Leu Ser Pro Gly Lys 
705                 710     

<210> 33
<211> 714
<212> PRT
<213> Artificial Sequence


<220> 
<223> example

<400> 33
Gln Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
1               5                   10                  15      
Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
            20                  25                  30          
Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
        35                  40                  45              
Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
    50                  55                  60                  
Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
65                  70                  75                  80  
Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
                85                  90                  95      
Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
            100                 105                 110         
Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
        115                 120                 125             
Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
    130                 135                 140                 
Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser Gly Asn Gly 
145                 150                 155                 160 
Ser Gly Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
                165                 170                 175     
Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
            180                 185                 190         
Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
        195                 200                 205             
Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
    210                 215                 220                 
Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
225                 230                 235                 240 
Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
                245                 250                 255     
Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
            260                 265                 270         
Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
        275                 280                 285             
His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
    290                 295                 300                 
Gly Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser Gly Asn 
305                 310                 315                 320 
Gly Ser Gly Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
                325                 330                 335     
Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly 
            340                 345                 350         
Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
        355                 360                 365             
Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu 
    370                 375                 380                 
Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
385                 390                 395                 400 
His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 
                405                 410                 415     
Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe 
            420                 425                 430         
Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly 
        435                 440                 445             
Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
    450                 455                 460                 
Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser Ser Ser Ser 
465                 470                 475                 480 
Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                485                 490                 495     
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            500                 505                 510         
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        515                 520                 525             
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    530                 535                 540                 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
545                 550                 555                 560 
Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                565                 570                 575     
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            580                 585                 590         
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        595                 600                 605             
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
    610                 615                 620                 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
625                 630                 635                 640 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                645                 650                 655     
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            660                 665                 670         
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        675                 680                 685             
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    690                 695                 700                 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
705                 710                 

<210> 34
<211> 714
<212> PRT
<213> Artificial Sequence


<220> 
<223> example

<400> 34
Ser Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
1               5                   10                  15      
Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
            20                  25                  30          
Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
        35                  40                  45              
Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
    50                  55                  60                  
Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
65                  70                  75                  80  
Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
                85                  90                  95      
Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
            100                 105                 110         
Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
        115                 120                 125             
Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
    130                 135                 140                 
Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser Gly Asn Gly 
145                 150                 155                 160 
Ser Gly Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
                165                 170                 175     
Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
            180                 185                 190         
Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
        195                 200                 205             
Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
    210                 215                 220                 
Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
225                 230                 235                 240 
Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
                245                 250                 255     
Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
            260                 265                 270         
Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
        275                 280                 285             
His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
    290                 295                 300                 
Gly Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser Gly Asn 
305                 310                 315                 320 
Gly Ser Gly Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
                325                 330                 335     
Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly 
            340                 345                 350         
Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
        355                 360                 365             
Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu 
    370                 375                 380                 
Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
385                 390                 395                 400 
His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 
                405                 410                 415     
Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe 
            420                 425                 430         
Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly 
        435                 440                 445             
Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
    450                 455                 460                 
Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser Ser Ser Ser 
465                 470                 475                 480 
Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                485                 490                 495     
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            500                 505                 510         
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        515                 520                 525             
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    530                 535                 540                 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
545                 550                 555                 560 
Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                565                 570                 575     
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            580                 585                 590         
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        595                 600                 605             
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
    610                 615                 620                 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
625                 630                 635                 640 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                645                 650                 655     
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            660                 665                 670         
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        675                 680                 685             
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    690                 695                 700                 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
705                 710                 

<210> 35
<211> 711
<212> PRT
<213> Artificial Sequence


<220> 
<223> FAKE SEQ --> PLEASE REPLACE BY CORRECT SEQ

<400> 35
Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
1               5                   10                  15      
Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
            20                  25                  30          
Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
        35                  40                  45              
Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
    50                  55                  60                  
Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
65                  70                  75                  80  
Pro Leu Arg Ser Ala Asn Gly Ser Ala Ala Leu Ala Leu Thr Val Asp 
                85                  90                  95      
Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
            100                 105                 110         
Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
        115                 120                 125             
His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
    130                 135                 140                 
Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser Gly Asn Gly Ser 
145                 150                 155                 160 
Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
                165                 170                 175     
Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
            180                 185                 190         
Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
        195                 200                 205             
Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
    210                 215                 220                 
Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
225                 230                 235                 240 
Pro Leu Arg Ser Ala Asn Gly Ser Ala Ala Leu Ala Leu Thr Val Asp 
                245                 250                 255     
Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
            260                 265                 270         
Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
        275                 280                 285             
His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
    290                 295                 300                 
Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser Gly Asn Gly Ser 
305                 310                 315                 320 
Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
                325                 330                 335     
Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
            340                 345                 350         
Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
        355                 360                 365             
Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
    370                 375                 380                 
Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
385                 390                 395                 400 
Pro Leu Arg Ser Ala Asn Gly Ser Ala Ala Leu Ala Leu Thr Val Asp 
                405                 410                 415     
Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
            420                 425                 430         
Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
        435                 440                 445             
His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
    450                 455                 460                 
Thr Val Leu Gly Leu Phe Arg Val Gly Ser Ser Ser Ser Ser Ser Ser 
465                 470                 475                 480 
Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                485                 490                 495     
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            500                 505                 510         
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        515                 520                 525             
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    530                 535                 540                 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
545                 550                 555                 560 
Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                565                 570                 575     
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            580                 585                 590         
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        595                 600                 605             
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    610                 615                 620                 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
625                 630                 635                 640 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                645                 650                 655     
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            660                 665                 670         
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        675                 680                 685             
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    690                 695                 700                 
Leu Ser Leu Ser Pro Gly Lys 
705                 710     

<210> 36
<211> 472
<212> PRT
<213> Artificial Sequence


<220> 
<223> example of scCD137L-RBD module

<400> 36
Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
1               5                   10                  15      
Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
            20                  25                  30          
Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
        35                  40                  45              
Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
    50                  55                  60                  
Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
65                  70                  75                  80  
Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                85                  90                  95      
Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
            100                 105                 110         
Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
        115                 120                 125             
His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
    130                 135                 140                 
Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser Gly Asn Gly Ser 
145                 150                 155                 160 
Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
                165                 170                 175     
Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
            180                 185                 190         
Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
        195                 200                 205             
Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
    210                 215                 220                 
Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
225                 230                 235                 240 
Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                245                 250                 255     
Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
            260                 265                 270         
Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
        275                 280                 285             
His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
    290                 295                 300                 
Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser Gly Asn Gly Ser 
305                 310                 315                 320 
Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
                325                 330                 335     
Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
            340                 345                 350         
Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
        355                 360                 365             
Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
    370                 375                 380                 
Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
385                 390                 395                 400 
Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                405                 410                 415     
Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
            420                 425                 430         
Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
        435                 440                 445             
His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
    450                 455                 460                 
Thr Val Leu Gly Leu Phe Arg Val 
465                 470         

<210> 37
<211> 2240
<212> DNA
<213> Artificial Sequence


<220> 
<223> DNA sequence encoding SEQ ID NO:25

<400> 37
aagctttagg gataacaggg taatagccgc caccatggag actgacaccc tgctggtgtt      60

cgtgctgctg gtctgggtgc ctgcaggaaa tggacagggc atgttcgctc aactggtcgc     120

acagaacgtg ctgctcattg acggtcccct gtcttggtac tccgatccag ggttggcagg     180

agtgtccttg acaggagggc tgtcctataa ggaggatacc aaagagctgg tggtagcaaa     240

ggctggtgtg tattacgtgt tctttcagct ggagctgcgc agagtcgtcg caggcgaagg     300

atctggtagt gtgtcactgg cactgcactt gcagcccctt cggtccgctg ccggggcagc     360

agcactggcc ctgaccgtcg atctgccacc cgcttctagc gaggcacgaa actcagcctt     420

tgggtttcag ggtcgcctgc tgcacctgag cgccggacag aggctgggcg ttcatctgca     480

caccgaggcc agagccagac acgcttggca gttgactcag ggagctacgg tcctcggtct     540

gtttcgagta ggcagcggaa gcggcaatgg ctctcagggc atgtttgctc agctggtagc     600

ccagaacgta ctcctgatcg atggccctct ttcatggtac tcagaccccg gactggccgg     660

agttagcctt acaggtgggc ttagttataa ggaggacaca aaggaattgg ttgtggccaa     720

agctggcgtg tactatgtgt tcttccagct tgagctccgc agagtcgtgg ctggggaggg     780

ctctggcagt gtgagccttg cccttcatct gcaacctttg cggagcgcag ccggcgctgc     840

tgcactggcc cttacagtgg atttgccacc cgcaagtagt gaagctcgca attccgcatt     900

cggtttccag ggccgtctgc tccatctttc tgccggtcaa cgtctgggag ttcacctcca     960

cactgaggct agggccaggc atgcttggca gctgactcaa ggagccactg tcttgggact    1020

ctttcgggta ggctccgggt ctggcaacgg ctcccagggg atgtttgccc aactggtcgc    1080

ccagaatgtc ctgctcatcg atggtcctct gagctggtat tccgaccctg gactggctgg    1140

tgtgagcctg actggcggac tctcctacaa agaggacacc aaggaactgg tggtggccaa    1200

agccggggtg tactacgtgt tcttccagtt ggaactgcgg cgggttgtgg ctggcgaggg    1260

atcaggttcc gttagtctgg ccctgcacct ccagcctctg aggtctgctg ctggtgccgc    1320

cgctctggcc ttgaccgtcg acctcccacc cgcatcttcc gaagcccgaa attcagcctt    1380

cgggttccag ggcagactgc tgcatctgag tgctggacag cgccttgggg ttcatctcca    1440

caccgaagcc agggcccgac atgcctggca gctcacacaa ggcgcaaccg ttttggggct    1500

ctttcgtgtg ggatcctcga gttcatcgtc ctcatccggc tcatgtgata agacccacac    1560

ctgccctccc tgtcctgccc ctgagctgct gggcggacct tctgtgttcc tgttcccccc    1620

caagcctaag gacaccctga tgatctccag gacccctgag gtgacctgtg tggtggtgga    1680

cgtgtctcac gaagatcccg aggtgaagtt caactggtac gtggacggcg tggaggtcca    1740

caacgccaag accaagccta gggaggagca gtacagctcc acctaccggg tggtgtctgt    1800

gctgaccgtg ctgcaccagg attggctgaa cggaaaggag tataagtgta aggtctccaa    1860

caaggccctg cctgccccca tcgagaaaac catctccaag gccaagggcc agcctcggga    1920

gcctcaggtg tacaccctgc ctcctagcag ggaggagatg accaagaacc aggtgtccct    1980

gacctgtctg gtgaagggct tctacccttc cgatatcgcc gtggagtggg agtctaatgg    2040

ccagcccgag aacaactaca agaccacccc tcctgtgctg gactctgacg gctccttctt    2100

cctgtactcc aagctgaccg tggacaagtc cagatggcag cagggcaacg tgttctcctg    2160

ctccgtgatg cacgaggccc tgcacaatca ctacacccag aagtccctgt ctctgagtcc    2220

gggcaagtaa taggcgcgcc                                                2240


<210> 38
<211> 229
<212> PRT
<213> Artificial Sequence


<220> 
<223> homotrimeric CD137L fused to RB69 FOLDON

<400> 38
Met Glu Thr Asp Thr Leu Leu Val Phe Val Leu Leu Val Trp Val Pro 
1               5                   10                  15      
Ala Gly Asn Gly Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
            20                  25                  30          
Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
        35                  40                  45              
Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
    50                  55                  60                  
Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
65                  70                  75                  80  
Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
                85                  90                  95      
Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
            100                 105                 110         
Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
        115                 120                 125             
Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
    130                 135                 140                 
Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
145                 150                 155                 160 
Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser 
                165                 170                 175     
Ser Gly Ser Ser Gly Ser Ser Gly Ser Gly Tyr Ile Glu Asp Ala Pro 
            180                 185                 190         
Ser Asp Gly Lys Phe Tyr Val Arg Lys Asp Gly Ala Trp Val Glu Leu 
        195                 200                 205             
Pro Thr Ala Ser Gly Pro Ser Ser Ser Ser Ser Ser Ala Trp Ser His 
    210                 215                 220                 
Pro Gln Phe Glu Lys 
225                 

<210> 39
<211> 481
<212> PRT
<213> Artificial Sequence


<220> 
<223> single chain CD137 lignad RBD (example)

<400> 39
Gln Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
1               5                   10                  15      
Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly 
            20                  25                  30          
Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
        35                  40                  45              
Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu 
    50                  55                  60                  
Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
65                  70                  75                  80  
His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 
                85                  90                  95      
Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe 
            100                 105                 110         
Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly 
        115                 120                 125             
Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
    130                 135                 140                 
Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser Gly 
145                 150                 155                 160 
Asn Gly Ser Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln 
                165                 170                 175     
Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly 
            180                 185                 190         
Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr 
        195                 200                 205             
Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln 
    210                 215                 220                 
Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser 
225                 230                 235                 240 
Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala 
                245                 250                 255     
Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn 
            260                 265                 270         
Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln 
        275                 280                 285             
Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp 
    290                 295                 300                 
Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser 
305                 310                 315                 320 
Gly Ser Gly Asn Gly Ser Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
                325                 330                 335     
Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            340                 345                 350         
Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
        355                 360                 365             
Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    370                 375                 380                 
Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
385                 390                 395                 400 
Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                405                 410                 415     
Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            420                 425                 430         
Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        435                 440                 445             
Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    450                 455                 460                 
His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
465                 470                 475                 480 
Val 
    

<210> 40
<211> 475
<212> PRT
<213> Artificial Sequence


<220> 
<223> single chain CD137 lignad RBD (example)

<400> 40
Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
1               5                   10                  15      
Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
            20                  25                  30          
Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
        35                  40                  45              
Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
    50                  55                  60                  
Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
65                  70                  75                  80  
Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
                85                  90                  95      
Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
            100                 105                 110         
Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
        115                 120                 125             
Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
    130                 135                 140                 
Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser Gly Asn Gly 
145                 150                 155                 160 
Ser Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
                165                 170                 175     
Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
            180                 185                 190         
Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
        195                 200                 205             
Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
    210                 215                 220                 
Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
225                 230                 235                 240 
Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
                245                 250                 255     
Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
            260                 265                 270         
Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
        275                 280                 285             
His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
    290                 295                 300                 
Gly Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser Gly Asn 
305                 310                 315                 320 
Gly Ser Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
                325                 330                 335     
Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly 
            340                 345                 350         
Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
        355                 360                 365             
Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu 
    370                 375                 380                 
Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
385                 390                 395                 400 
His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 
                405                 410                 415     
Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe 
            420                 425                 430         
Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly 
        435                 440                 445             
Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
    450                 455                 460                 
Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
465                 470                 475 

<210> 41
<211> 475
<212> PRT
<213> Artificial Sequence


<220> 
<223> single chain CD137 lignad RBD (example)

<400> 41
Gln Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
1               5                   10                  15      
Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
            20                  25                  30          
Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
        35                  40                  45              
Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
    50                  55                  60                  
Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
65                  70                  75                  80  
Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
                85                  90                  95      
Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
            100                 105                 110         
Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
        115                 120                 125             
Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
    130                 135                 140                 
Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser Gly Asn Gly 
145                 150                 155                 160 
Ser Gly Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
                165                 170                 175     
Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
            180                 185                 190         
Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
        195                 200                 205             
Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
    210                 215                 220                 
Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
225                 230                 235                 240 
Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
                245                 250                 255     
Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
            260                 265                 270         
Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
        275                 280                 285             
His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
    290                 295                 300                 
Gly Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser Gly Asn 
305                 310                 315                 320 
Gly Ser Gly Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
                325                 330                 335     
Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly 
            340                 345                 350         
Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
        355                 360                 365             
Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu 
    370                 375                 380                 
Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
385                 390                 395                 400 
His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 
                405                 410                 415     
Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe 
            420                 425                 430         
Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly 
        435                 440                 445             
Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
    450                 455                 460                 
Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
465                 470                 475 

<210> 42
<211> 475
<212> PRT
<213> Artificial Sequence


<220> 
<223> single chain CD137 lignad RBD (example)

<400> 42
Ser Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
1               5                   10                  15      
Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
            20                  25                  30          
Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
        35                  40                  45              
Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
    50                  55                  60                  
Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
65                  70                  75                  80  
Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
                85                  90                  95      
Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
            100                 105                 110         
Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
        115                 120                 125             
Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
    130                 135                 140                 
Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser Gly Asn Gly 
145                 150                 155                 160 
Ser Gly Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
                165                 170                 175     
Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
            180                 185                 190         
Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
        195                 200                 205             
Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
    210                 215                 220                 
Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
225                 230                 235                 240 
Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
                245                 250                 255     
Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
            260                 265                 270         
Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
        275                 280                 285             
His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
    290                 295                 300                 
Gly Ala Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser Gly Asn 
305                 310                 315                 320 
Gly Ser Gly Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
                325                 330                 335     
Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly 
            340                 345                 350         
Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
        355                 360                 365             
Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu 
    370                 375                 380                 
Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
385                 390                 395                 400 
His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 
                405                 410                 415     
Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe 
            420                 425                 430         
Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly 
        435                 440                 445             
Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
    450                 455                 460                 
Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
465                 470                 475 

<210> 43
<211> 472
<212> PRT
<213> Artificial Sequence


<220> 
<223> single chain CD137 lignad RBD (example)

<400> 43
Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
1               5                   10                  15      
Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
            20                  25                  30          
Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
        35                  40                  45              
Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
    50                  55                  60                  
Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
65                  70                  75                  80  
Pro Leu Arg Ser Ala Asn Gly Ser Ala Ala Leu Ala Leu Thr Val Asp 
                85                  90                  95      
Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
            100                 105                 110         
Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
        115                 120                 125             
His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
    130                 135                 140                 
Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser Gly Asn Gly Ser 
145                 150                 155                 160 
Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
                165                 170                 175     
Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
            180                 185                 190         
Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
        195                 200                 205             
Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
    210                 215                 220                 
Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
225                 230                 235                 240 
Pro Leu Arg Ser Ala Asn Gly Ser Ala Ala Leu Ala Leu Thr Val Asp 
                245                 250                 255     
Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
            260                 265                 270         
Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
        275                 280                 285             
His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
    290                 295                 300                 
Thr Val Leu Gly Leu Phe Arg Val Gly Ser Gly Ser Gly Asn Gly Ser 
305                 310                 315                 320 
Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
                325                 330                 335     
Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
            340                 345                 350         
Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
        355                 360                 365             
Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
    370                 375                 380                 
Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
385                 390                 395                 400 
Pro Leu Arg Ser Ala Asn Gly Ser Ala Ala Leu Ala Leu Thr Val Asp 
                405                 410                 415     
Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
            420                 425                 430         
Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
        435                 440                 445             
His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
    450                 455                 460                 
Thr Val Leu Gly Leu Phe Arg Val 
465                 470         

