                               SEQUENCE LISTING

<110> THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
      SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
      JESSUP, JOHN MILBURN AND ZHANG, JINGYU	
 
<120> PHARMACEUTICAL COMPOSITION COMPRISING NANOG SHRNA, AND METHOD OF 
      USING NANOG SHRNA TO TREAT CANCER

<130> NIHB-2602

<140> 
<141>

<150> PCT/US2011/063451
<151> 2011-12-06

<150> 61/420,214
<151> 2010-12-06

<160> 61    

<170> PatentIn version 3.5

<210> 1
<211> 2098
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
attataaatc tagagactcc aggattttaa cgttctgctg gactgagctg gttgcctcat       60

gttattatgc aggcaactca ctttatccca atttcttgat acttttcctt ctggaggtcc      120

tatttctcta acatcttcca gaaaagtctt aaagctgcct taaccttttt tccagtccac      180

ctcttaaatt ttttcctcct cttcctctat actaacatga gtgtggatcc agcttgtccc      240

caaagcttgc cttgctttga agcatccgac tgtaaagaat cttcacctat gcctgtgatt      300

tgtgggcctg aagaaaacta tccatccttg caaatgtctt ctgctgagat gcctcacacg      360

gagactgtct ctcctcttcc ttcctccatg gatctgctta ttcaggacag ccctgattct      420

tccaccagtc ccaaaggcaa acaacccact tctgcagaga agagtgtcgc aaaaaaggaa      480

gacaaggtcc cggtcaagaa acagaagacc agaactgtgt tctcttccac ccagctgtgt      540

gtactcaatg atagatttca gagacagaaa tacctcagcc tccagcagat gcaagaactc      600

tccaacatcc tgaacctcag ctacaaacag gtgaagacct ggttccagaa ccagagaatg      660

aaatctaaga ggtggcagaa aaacaactgg ccgaagaata gcaatggtgt gacgcagaag      720

gcctcagcac ctacctaccc cagcctttac tcttcctacc accagggatg cctggtgaac      780

ccgactggga accttccaat gtggagcaac cagacctgga acaattcaac ctggagcaac      840

cagacccaga acatccagtc ctggagcaac cactcctgga acactcagac ctggtgcacc      900

caatcctgga acaatcaggc ctggaacagt cccttctata actgtggaga ggaatctctg      960

cagtcctgca tgcagttcca gccaaattct cctgccagtg acttggaggc tgccttggaa     1020

gctgctgggg aaggccttaa tgtaatacag cagaccacta ggtattttag tactccacaa     1080

accatggatt tattcctaaa ctactccatg aacatgcaac ctgaagacgt gtgaagatga     1140

gtgaaactga tattactcaa tttcagtctg gacactggct gaatccttcc tctcccctcc     1200

tcccatccct cataggattt ttcttgtttg gaaaccacgt gttctggttt ccatgatgcc     1260

catccagtca atctcatgga gggtggagta tggttggagc ctaatcagcg aggtttcttt     1320

tttttttttt ttcctattgg atcttcctgg agaaaatact tttttttttt ttttttttga     1380

aacggagtct tgctctgtcg cccaggctgg agtgcagtgg cgcggtcttg gctcactgca     1440

agctccgtct cccgggttca cgccattctc ctgcctcagc ctcccgagca gctgggacta     1500

caggcgcccg ccacctcgcc cggctaatat tttgtatttt tagtagagac ggggtttcac     1560

tgtgttagcc aggatggtct cgatctcctg accttgtgat ccacccgcct cggcctccct     1620

aacagctggg atttacaggc gtgagccacc gcgccctgcc tagaaaagac attttaataa     1680

ccttggctgc cgtctctggc tatagataag tagatctaat actagtttgg atatctttag     1740

ggtttagaat ctaacctcaa gaataagaaa tacaagtaca aattggtgat gaagatgtat     1800

tcgtattgtt tgggattggg aggctttgct tattttttaa aaactattga ggtaaagggt     1860

taagctgtaa catacttaat tgatttctta ccgtttttgg ctctgttttg ctatatcccc     1920

taatttgttg gttgtgctaa tctttgtaga aagaggtctc gtatttgctg catcgtaatg     1980

acatgagtac tgctttagtt ggtttaagtt caaatgaatg aaacaactat ttttccttta     2040

gttgatttta ccctgatttc accgagtgtt tcaatgagta aatatacagc ttaaacat       2098


<210> 2
<211> 2083
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
ccaggatttt aacgttctgc tggactgagc tggttgcctc atgttattat gcaggcaact       60

cactttatcc caatttcttg atacttttcc ttctggaggt cctatttctc taacatcttc      120

cagaaaagtc ttaaagctgc cttaaccttt tttccagtcc acctcttaaa ttttttcctc      180

ctcttcctct atactaacat gagtgtggat ccagcttgtc cccaaagctt gccttgcttt      240

gaagaatccg actgtaaaga atcttcacct atgcctgtga tttgtgggcc tgaagaaaac      300

tatccatcct tgcaaatgtc ttctgctgag atgcctcaca cagagactgt ctctcctctt      360

ccttcctcca tggatctgct tattcaggac agccctgatt cttccaccag tcccaaaggc      420

aaacaaccca cttctgcaga gaatagtgtc gcaaaaaagg aagacaaggt cccggtcaag      480

aaacagaaga ccagaactgt gttctcttcc acccagctgt gtgtactcaa tgatagattt      540

cagagacaga aatacctcag cctccagcag atgcaagaac tctccaacat cctgaacctc      600

agctacaaac aggtgaagac ctggttccag aaccagagaa tgaaatctaa gaggtggcag      660

aaaaacaact ggccgaagaa tagcaatggt gtgacgcaga aggcctcagc acctacctac      720

cccagcctct actcttccta ccaccaggga tgcctggtga acccgactgg gaaccttcca      780

atgtggagca accagacctg gaacaattca acctggagca accagaccca gaacatccag      840

tcctggagca accactcctg gaacactcag acctggtgca cccaatcctg gaacaatcag      900

gcctggaaca gtcccttcta taactgtgga gaggaatctc tgcagtcctg catgcacttc      960

cagccaaatt ctcctgccag tgacttggag gctgccttgg aagctgctgg ggaaggcctt     1020

aatgtaatac agcagaccac taggtatttt agtactccac aaaccatgga tttattccta     1080

aactactcca tgaacatgca acctgaagac gtgtgaagat gagtgaaact gatattactc     1140

aatttcagtc tggacactgg ctgaatcctt cctctcccct cctcccatcc ttcataggat     1200

ttttcttgtt tggaaaccac gtgttctggt ttccatgatg cccatccagt caatctcatg     1260

gagggtggag tatggttgga gcctaatcag cgaggtttct tttttttttt ttttttccta     1320

ttggatcttc ctggagaaaa tacttttttt tttttttttt tttgagacgg agtcttgctc     1380

tgtcgcccag gctggagtgc agtggcgcgg tcttggctca ctgcaagctc cgtctgccgg     1440

gttcacgcca ttctcctgcc tcagcctccc gagcagctgg gactacaggc gcccgccacc     1500

tcgcccggct aatattttgt atttttagta gagacggggt ttcactgtgt tagccaggat     1560

ggtctcgatc tcctgacctt gtgatccgcc cgcctcggcc tccctaacag ctgggattta     1620

caggcgtgag ccaccgcgcc ctgcctagaa aagacatttt aataaccttg gctgccgtct     1680

ctggctatag ataagtagat ctaatacgag tttggatatc tttagggttt agaatctaac     1740

ctcaagaata agaaatacaa gtacaaattg gtgatgaaga tgtattcgta ttgtttggga     1800

ttgggaggct ttgcttattt tttaaaaact attgaggtaa agggttaagc tgtaacatac     1860

ttaattgatt tcttaccgtt tttggctctg ttttgctata tcccctaatt tgttggttgt     1920

gctaatcttt gtagaaagag gtctcgtatt tgctgcatcg taatgacatg agtactactt     1980

tagttggttt aagttcaaat gaatgaaaca actatttttc ctttagttga ttttaccctg     2040

atttcaccga gtgtttcaat gagtaaatat acagcttaaa cat                       2083


<210> 3
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
gaggcagcag agaccgctgc atgcacttcc agcca                                  35


<210> 4
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
tctgacagga agtggctgga agtgcatgca g                                      31


<210> 5
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
cttcctgtca gatggctgga agtgcatgca gttttt                                 36


<210> 6
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
cgaacagaga gagaccgaaa aactgcatgc acttccagcc a                           41


<210> 7
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
gaggcagcag agaccgctgc atgcacttcc agccg                                  35


<210> 8
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
tctgacagga agtggctgga agtgcatgca g                                      31


<210> 9
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
cttcctgtca gatggctgga agtgcatgca gttttt                                 36


<210> 10
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
cgaacagaga gagaccgaaa aactgcatgc acttccagcc g                           41


<210> 11
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
gaggcagcag agaccgttgt gatccgcccg cctcg                                  35


<210> 12
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
tctgacagga agcgaggcgg gcggatcaca a                                      31


<210> 13
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
cttcctgtca gacgaggcgg gcggatcaca attttt                                 36


<210> 14
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
cgaacagaga gagaccgaaa aattgtgatc cgcccgcctc g                           41


<210> 15
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
gaggcagcag agaccgatct aatacgagtt tggata                                 36


<210> 16
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
tctgacagga agtatccaaa ctcgtattag at                                     32


<210> 17
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
cttcctgtca gatatccaaa ctcgtattag atttttt                                37


<210> 18
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
cgaacagaga gagaccgaaa aaatctaata cgagtttgga ta                          42


<210> 19
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
gaggcagcag agaccgatct aatacgagtt tggatg                                 36


<210> 20
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
cgaacagaga gagaccgaaa aaatctaata cgagtttgga tg                          42


<210> 21
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
gaggcagcag agaccgatga gtactacttt agttg                                  35


<210> 22
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
tctgacagga agcaactaaa gtagtactca t                                      31


<210> 23
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
cttcctgtca gacaactaaa gtagtactca tttttt                                 36


<210> 24
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
cgaacagaga gagaccgaaa aaatgagtac tactttagtt g                           41


<210> 25
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
gaggcagcag agaccgaaca aagcacatct tgccagga                               38


<210> 26
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
tctgacagga agtcctggca agatgtgctt tgtt                                   34


<210> 27
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
cttcctgtca gatcctggca agatgtgctt tgttttttt                              39


<210> 28
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
cgaacagaga gagaccgaaa aaaacaaagc acatcttgcc agga                        44


<210> 29
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
gaggcagcag agaccgaaca aagcacatct tgccaggg                               38


<210> 30
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
tctgacagga agtcctggca agatgtgctt tgtt                                   34


<210> 31
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
cttcctgtca gatcctggca agatgtgctt tgttttttt                              39


<210> 32
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
cgaacagaga gagaccgaaa aaaacaaagc acatcttgcc aggg                        44


<210> 33
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 33
gaggcagcag agaccgctgc atgcagttcc agcca                                  35


<210> 34
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 34
tctgacagga agtggctgga actgcatgca g                                      31


<210> 35
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 35
cttcctgtca gatggctgga actgcatgca gttttt                                 36


<210> 36
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 36
cgaacagaga gagaccgaaa aactgcatgc agttccagcc a                           41


<210> 37
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 37
gaggcagcag agaccgctgc atgcagttcc agccg                                  35


<210> 38
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 38
tctgacagga agtggctgga actgcatgca g                                      31


<210> 39
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 39
cttcctgtca gatggctgga actgcatgca gttttt                                 36


<210> 40
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 40
cgaacagaga gagaccgaaa aactgcatgc agttccagcc g                           41


<210> 41
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 41
gaggcagcag agaccgtagc gactaaacac atcaa                                  35


<210> 42
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 42
tctgacagga agttgatgtg tttagtcgct a                                      31


<210> 43
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 43
cttcctgtca gattgatgtg tttagtcgct attttt                                 36


<210> 44
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 44
cgaacagaga gagaccgaaa aatagcgact aaacacatca a                           41


<210> 45
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 45
ccgggctgct aaggacaaca ttgatctcga gatcaatgtt gtccttagca gcttttt          57


<210> 46
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 46
ccgggctttg aagcatccga ctgtactcga gtacagtcgg atgcttcaaa gcttttt          57


<210> 47
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 47
ccggctgtaa agaatcttca cctatctcga gataggtgaa gattctttac agttttt          57


<210> 48
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 48
ccggcctgga acagtccctt ctatactcga gtatagaagg gactgttcca ggttttt          57


<210> 49
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 49
ccggcctaaa ctactccatg aacatctcga gatgttcatg gagtagttta ggttttt          57


<210> 50
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 50
ctgcatgcag ttccagcca                                                    19


<210> 51
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 51
tggctggaac tgcatgcag                                                    19


<210> 52
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 52
ctgcatgcag ttccagccg                                                    19


<210> 53
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 53
tggctggaac tgcatgcag                                                    19


<210> 54
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 54
ctgcatgcac ttccagcca                                                    19


<210> 55
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 55
tggctggaag tgcatgcag                                                    19


<210> 56
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 56
ctgcatgcac ttccagccg                                                    19


<210> 57
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 57
tggctggaag tgcatgcag                                                    19


<210> 58
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 58
Lys Thr Trp Phe Gln Asn Gln Arg Met 
1               5                   


<210> 59
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 59
Lys Tyr Leu Ser Leu Gln Gln Met Gln Glu Leu Ser Asn Ile Leu Asn 
1               5                   10                  15      


Leu Ser Tyr Lys Gln 
            20      


<210> 60
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 60
Lys Lys Glu Asp Lys Val Pro Val Lys Lys 
1               5                   10  


<210> 61
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 61
Lys Gly Lys Gln Pro Thr Ser Ala Glu Asn Ser Val Ala Lys Lys 
1               5                   10                  15  


