                         SEQUENCE LISTING

<110>  HERA TESTING LABORATORIES, INC.
 
<120>  GENETICALLY MODIFIED NON-HUMAN MAMMALS HAVING MODIFIED LIVER 
       CELLS AND/OR TISSUE AND METHODS OF MAKING SAME

<130>  0639353

<150>  62/245,049
<151>  2015-10-22

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  1061
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LPS Promoter

<400>  1
gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc       60

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      120

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      180

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      240

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      300

tttaggtagt gtgagagggt ccggcgatta actgcaggct cagaggcaca caggagtttc      360

tgggctcacc ctgccccctt ccaacccctc agttcccatc ctccagcagc tgtttgtgtg      420

ctgcctctga agtccacact gaacaaactt cagcctactc atgtccctaa aatgggcaaa      480

cattgcaagc agcaaacagc aaacacacag ccctccctgc ctgctgacct tggagctggg      540

gcagaggtca gagacctctc tgggcccatg ccacctccaa catccactcg accccttgga      600

atttcggtgg agaggagcag aggttgtcct ggcgtggttt aggtagtgtg agagggtccg      660

gcgaattaat gctaccagtg gaacagccac taaggattct gcagtgagag cagagggcca      720

gctaagtggt actctcccag agactgtctg actcacgcca ccccctccac cttggacaca      780

ggacgctgtg gtttctgagc caggtacaat gactcctttc ggtaagtgca gtggaagctg      840

tacactgccc aggcaaagcg tccgggcagc gtaggcgggc gactcagatc ccagccagtg      900

gacttagccc ctgtttgctc ctccgataac tggggtgacc ttggttaata ttcaccagca      960

gcctcccccg ttgcccctct ggatccactg cttaaatacg gacgaggaca gggccctgtc     1020

tcctcagctt caggcaccac cactgacctg ggacagtgaa t                         1061


<210>  2
<211>  193
<212>  DNA
<213>  Rattus norvegicus

<400>  2
agcttcagat ggcaaacata cgcaagggat ttagttaaac aacttttttt tttctttttg       60

gcaaggatgg tatgattttg taatggggta ggaaccaatg aactgaaagg ttagtgtggt      120

taatgatcta cagttattgg ttagagaagt atattagagc gagtttctct gcacacagac      180

cacctttcct gtc                                                         193


<210>  3
<211>  3402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rAAV-PB construct

<400>  3
accggtactg cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg ggcgtcgggc       60

gacctttggt cgcccggcct cagtgagcga gcgagcgcgc agagagggag tggccaactc      120

catcactagg ggttccttgt agttaatgat taacccgcca tgctacttat ctacgtagcc      180

atgctctagc ttaaggggct cagaggcaca caggagtttc tgggctcacc ctgccccctt      240

ccaacccctc agttcccatc ctccagcagc tgtttgtgtg ctgcctctga agtccacact      300

gaacaaactt cagcctactc atgtccctaa aatgggcaaa cattgcaagc agcaaacagc      360

aaacacacag ccctccctgc ctgctgacct tggagctggg gcagaggtca gagacctctc      420

tgggcccatg ccacctccaa catccactcg accccttgga atttcggtgg agaggagcag      480

aggttgtcct ggcgtggttt aggtagtgtg agagggtccg gcgattaact gcaggctcag      540

aggcacacag gagtttctgg gctcaccctg cccccttcca acccctcagt tcccatcctc      600

cagcagctgt ttgtgtgctg cctctgaagt ccacactgaa caaacttcag cctactcatg      660

tccctaaaat gggcaaacat tgcaagcagc aaacagcaaa cacacagccc tccctgcctg      720

ctgaccttgg agctggggca gaggtcagag acctctctgg gcccatgcca cctccaacat      780

ccactcgacc ccttggaatt tcggtggaga ggagcagagg ttgtcctggc gtggtttagg      840

tagtgtgaga gggtccggcg aattaatgct accagtggaa cagccactaa ggattctgca      900

gtgagagcag agggccagct aagtggtact ctcccagaga ctgtctgact cacgccaccc      960

cctccacctt ggacacagga cgctgtggtt tctgagccag gtacaatgac tcctttcggt     1020

aagtgcagtg gaagctgtac actgcccagg caaagcgtcc gggcagcgta ggcgggcgac     1080

tcagatccca gccagtggac ttagcccctg tttgctcctc cgataactgg ggtgaccttg     1140

gttaatattc accagcagcc tcccccgttg cccctctgga tccactgctt aaatacggac     1200

gaggacaggg ccctgtctcc tcagcttcag gcaccaccac tgacctggga cagtgaattg     1260

cgaattcgcc gccaccatgg ggtcttccct cgatgatgaa catatcctca gcgctctttt     1320

gcagtctgat gatgaattgg tcggtgagga tagtgactct gaggttagtg accatgtatc     1380

tgaagacgat gtgcagtccg acacggaaga ggctttcatc gatgaggtac acgaagtgca     1440

accgactagc tccgggagtg agattcttga tgagcagaat gtcatcgaac aacctggctc     1500

ttccttggca tccaaccgga tattgactct tcctcagcgc acaatacgag gcaagaataa     1560

acattgttgg tccaccagta aatcaacgcg ccggtcaaga gtttctgccc ttaatatcgt     1620

ccgaagtcaa aggggaccaa caagaatgtg ccgcaacata tatgatcctt tgttgtgctt     1680

taaacttttt ttcactgacg aaatcatatc tgaaatcgtc aagtggacca acgcagagat     1740

ttccctgaag agaagggagt ccatgaccag cgctacattt cgggatacca atgaagacga     1800

gatatacgca ttcttcggaa tattggtgat gaccgcagtt cgcaaggaca accacatgtc     1860

taccgatgat ttgttcgata gaagcctctc tatggtctat gtaagtgtga tgtcccggga     1920

taggtttgat tttcttatac gatgccttag aatggacgat aaatcaatac ggcccacgtt     1980

gcgagaaaac gatgtattta ccccagtgcg gaaaatctgg gacctcttca tccaccaatg     2040

catacaaaac tatacgcccg gggcacatct tactattgac gaacaactcc tcggctttag     2100

ggggcggtgt ccatttagag tctacattcc aaataagcct agtaaatacg ggattaaaat     2160

actcatgatg tgcgattccg ggaccaaata tatgataaac ggaatgccat atttgggtag     2220

agggacccag acaaacggag tgccactggg ggaatactat gtgaaagagt tgtcaaaacc     2280

agtacacggt tcttgtcgca acataacctg cgataactgg ttcacatcca tcccccttgc     2340

taagaacctg cttcaggaac cttacaaatt gacgatagtt ggaactgtca ggtcaaataa     2400

gagggagata ccggaagttt tgaagaatag tcgatctcga ccagtcggta cctcaatgtt     2460

ttgcttcgac ggacccctga cactggtttc atacaagcct aagcccgcca agatggtgta     2520

tctcctgtcc agctgtgacg aagacgcctc aatcaacgaa tcaaccggca aaccccaaat     2580

ggtgatgtat tataatcaaa cgaagggagg cgtcgatact ttggatcaga tgtgcagtgt     2640

tatgacatgc agtcgcaaaa ctaatcggtg gcccatggct ctcctctatg ggatgattaa     2700

cattgcttgt ataaactcct ttatcatcta ctcccataac gtatctagta agggtgagaa     2760

agtacagagc cggaaaaagt tcatgaggaa tttgtacatg agtctgacga gttccttcat     2820

gaggaaacgg ctcgaagctc caactcttaa aagatatctc agagacaaca tttccaatat     2880

ccttcctaaa gaagtccccg ggacgagtga tgatagcact gaagaacccg tgatgaaaaa     2940

gcgcacgtac tgcacctatt gtccttccaa gattcggcgg aaggctaatg catcttgtaa     3000

aaaatgtaaa aaggttattt gccgagaaca caacattgat atgtgccagt catgcttttg     3060

acaagcttgc aattccgata acttgtttat tgcagcttat aatggttaca aataaagcaa     3120

tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc     3180

caaactcatc aatgtatctt atcatgtctg gcgctagcag catggctacg tagataagta     3240

gcatggcggg ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc     3300

tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt     3360

tgcccgggcg gcctcagtga gcgagcgagc gcgcagacta gt                        3402


<210>  4
<211>  3525
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rAAV-PB-GFP construct

<400>  4
accggtactg cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg ggcgtcgggc       60

gacctttggt cgcccggcct cagtgagcga gcgagcgcgc agagagggag tggccaactc      120

catcactagg ggttccttgt agttaatgat taacccgcca tgctacttat ctacgtagcc      180

atgctctagc ttaagggtta accctagaaa gataatcata ttgtgacgta cgttaaagat      240

aatcatgcgt aaaattgacg catgaatccc tagggctcag aggcacacag gagtttctgg      300

gctcaccctg cccccttcca acccctcagt tcccatcctc cagcagctgt ttgtgtgctg      360

cctctgaagt ccacactgaa caaacttcag cctactcatg tccctaaaat gggcaaacat      420

tgcaagcagc aaacagcaaa cacacagccc tccctgcctg ctgaccttgg agctggggca      480

gaggtcagag acctctctgg gcccatgcca cctccaacat ccactcgacc ccttggaatt      540

tcggtggaga ggagcagagg ttgtcctggc gtggtttagg tagtgtgaga gggtccggcg      600

attaactgca ggctcagagg cacacaggag tttctgggct caccctgccc ccttccaacc      660

cctcagttcc catcctccag cagctgtttg tgtgctgcct ctgaagtcca cactgaacaa      720

acttcagcct actcatgtcc ctaaaatggg caaacattgc aagcagcaaa cagcaaacac      780

acagccctcc ctgcctgctg accttggagc tggggcagag gtcagagacc tctctgggcc      840

catgccacct ccaacatcca ctcgacccct tggaatttcg gtggagagga gcagaggttg      900

tcctggcgtg gtttaggtag tgtgagaggg tccggcgaat taatgctacc agtggaacag      960

ccactaagga ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg     1020

tctgactcac gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta     1080

caatgactcc tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg     1140

cagcgtaggc gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga     1200

taactggggt gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc     1260

actgcttaaa tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga     1320

cctgggacag tgaattgcga attcgccgcc accatggggt cttccctcga tgatgaacat     1380

atcctcagcg ctcttttgca gtctgatgat gaattggtcg gtgaggatag tgactctgag     1440

gttagtgacc atgtatctga agacgatgtg cagtccgaca cggaagaggc tttcatcgat     1500

gaggtacacg aagtgcaacc gactagctcc gggagtgaga ttcttgatga gcagaatgtc     1560

atcgaacaac ctggctcttc cttggcatcc aaccggatat tgactcttcc tcagcgcaca     1620

atacgaggca agaataaaca ttgttggtcc accagtaaat caacgcgccg gtcaagagtt     1680

tctgccctta atatcgtccg aagtcaaagg ggaccaacaa gaatgtgccg caacatatat     1740

gatcctttgt tgtgctttaa actttttttc actgacgaaa tcatatctga aatcgtcaag     1800

tggaccaacg cagagatttc cctgaagaga agggagtcca tgaccagcgc tacatttcgg     1860

gataccaatg aagacgagat atacgcattc ttcggaatat tggtgatgac cgcagttcgc     1920

aaggacaacc acatgtctac cgatgatttg ttcgatagaa gcctctctat ggtctatgta     1980

agtgtgatgt cccgggatag gtttgatttt cttatacgat gccttagaat ggacgataaa     2040

tcaatacggc ccacgttgcg agaaaacgat gtatttaccc cagtgcggaa aatctgggac     2100

ctcttcatcc accaatgcat acaaaactat acgcccgggg cacatcttac tattgacgaa     2160

caactcctcg gctttagggg gcggtgtcca tttagagtct acattccaaa taagcctagt     2220

aaatacggga ttaaaatact catgatgtgc gattccggga ccaaatatat gataaacgga     2280

atgccatatt tgggtagagg gacccagaca aacggagtgc cactggggga atactatgtg     2340

aaagagttgt caaaaccagt acacggttct tgtcgcaaca taacctgcga taactggttc     2400

acatccatcc cccttgctaa gaacctgctt caggaacctt acaaattgac gatagttgga     2460

actgtcaggt caaataagag ggagataccg gaagttttga agaatagtcg atctcgacca     2520

gtcggtacct caatgttttg cttcgacgga cccctgacac tggtttcata caagcctaag     2580

cccgccaaga tggtgtatct cctgtccagc tgtgacgaag acgcctcaat caacgaatca     2640

accggcaaac cccaaatggt gatgtattat aatcaaacga agggaggcgt cgatactttg     2700

gatcagatgt gcagtgttat gacatgcagt cgcaaaacta atcggtggcc catggctctc     2760

ctctatggga tgattaacat tgcttgtata aactccttta tcatctactc ccataacgta     2820

tctagtaagg gtgagaaagt acagagccgg aaaaagttca tgaggaattt gtacatgagt     2880

ctgacgagtt ccttcatgag gaaacggctc gaagctccaa ctcttaaaag atatctcaga     2940

gacaacattt ccaatatcct tcctaaagaa gtccccggga cgagtgatga tagcactgaa     3000

gaacccgtga tgaaaaagcg cacgtactgc acctattgtc cttccaagat tcggcggaag     3060

gctaatgcat cttgtaaaaa atgtaaaaag gttatttgcc gagaacacaa cattgatatg     3120

tgccagtcat gcttttgaca agcttgcaat tccgataact tgtttattgc agcttataat     3180

ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat     3240

tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctgacg cgtgcatgcg     3300

tcaattttac gcagactatc tttctagggt taagcgctag cagcatggct acgtagataa     3360

gtagcatggc gggttaatca ttaactacaa ggaaccccta gtgatggagt tggccactcc     3420

ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc gacgcccggg     3480

ctttgcccgg gcggcctcag tgagcgagcg agcgcgcaga ctagt                     3525


<210>  5
<211>  2735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rAAV-PB-dTK construct

<400>  5
accggtactg cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg ggcgtcgggc       60

gacctttggt cgcccggcct cagtgagcga gcgagcgcgc agagagggag tggccaactc      120

catcactagg ggttccttgt agttaatgat taacccgcca tgctacttat ctacgtagcc      180

atgctctagc ttaagggtta accctagaaa gataatcata ttgtgacgta cgttaaagat      240

aatcatgcgt aaaattgacg catgaatccc tagggctcag aggcacacag gagtttctgg      300

gctcaccctg cccccttcca acccctcagt tcccatcctc cagcagctgt ttgtgtgctg      360

cctctgaagt ccacactgaa caaacttcag cctactcatg tccctaaaat gggcaaacat      420

tgcaagcagc aaacagcaaa cacacagccc tccctgcctg ctgaccttgg agctggggca      480

gaggtcagag acctctctgg gcccatgcca cctccaacat ccactcgacc ccttggaatt      540

tcggtggaga ggagcagagg ttgtcctggc gtggtttagg tagtgtgaga gggtccggcg      600

attaactgca ggctcagagg cacacaggag tttctgggct caccctgccc ccttccaacc      660

cctcagttcc catcctccag cagctgtttg tgtgctgcct ctgaagtcca cactgaacaa      720

acttcagcct actcatgtcc ctaaaatggg caaacattgc aagcagcaaa cagcaaacac      780

acagccctcc ctgcctgctg accttggagc tggggcagag gtcagagacc tctctgggcc      840

catgccacct ccaacatcca ctcgacccct tggaatttcg gtggagagga gcagaggttg      900

tcctggcgtg gtttaggtag tgtgagaggg tccggcgaat taatgctacc agtggaacag      960

ccactaagga ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg     1020

tctgactcac gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta     1080

caatgactcc tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg     1140

cagcgtaggc gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga     1200

taactggggt gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc     1260

actgcttaaa tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga     1320

cctgggacag tgaattgcga attcgccgcc accatgccca cgctactgcg ggtttatata     1380

gacggtcccc acgggatggg gaaaaccacc accacgcaac tgctggtggc cctgggttcg     1440

cgcgacgata tcgtctacgt acccgagccg atgacttact ggcgggtgct gggggcttcc     1500

gagacaatcg cgaacatcta caccacacaa caccgccttg accagggtga gatatcggcc     1560

ggggacgcgg cggtggtaat gacaagcgcc cagataacaa tgggcatgcc ttatgccgtg     1620

accgacgccg ttctggctcc tcatatcggg ggggaggctg ggagctcaca tgccccgccc     1680

ccggccctca ccctcatctt cgaccgccat cccatcgccg ccctcctgtg ctacccggcc     1740

gcgcgatacc ttatgggcag catgaccccc caggccgtgc tggcgttcgt ggccctcatc     1800

ccgccgacct tgcccggcac aaacatcgtg ttgggggccc ttccggagga cagacacatc     1860

gaccgcctgg ccaaacgcca gcgccccggc gagcggcttg acctggctat gctggccgcg     1920

attcgccgcg tttacgggct gcttgccaat acggtgcggt atctgcaggg cggcgggtcg     1980

tggcgggagg attggggaca gctttcgggg acggccgtgc cgccccaggg tgccgagccc     2040

cagagcaacg cgggcccacg accccatatc ggggacacgt tatttaccct gtttcgggcc     2100

cccgagttgc tggcccccaa cggcgacctg tacaacgtgt ttgcctgggc cttggacgtc     2160

ttggccaaac gcctccgtcc catgcacgtc tttatcctgg attacgacca atcgcccgcc     2220

ggctgccggg acgccctgct gcaacttacc tccgggatga tccagaccca cgtcaccacc     2280

ccaggctcca taccgacgat ctgcgacctg gcgcgcacgt ttgcccggga gatgggggag     2340

gctaactgac aagcttgcaa ttccgataac ttgtttattg cagcttataa tggttacaaa     2400

taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca ttctagttgt     2460

ggtttgtcca aactcatcaa tgtatcttat catgtctgac gcgtgcatgc gtcaatttta     2520

cgcagactat ctttctaggg ttaagcgcta gcagcatggc tacgtagata agtagcatgg     2580

cgggttaatc attaactaca aggaacccct agtgatggag ttggccactc cctctctgcg     2640

cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg     2700

ggcggcctca gtagcgagcg agcgcgcaga ctagt                                2735


