                         SEQUENCE LISTING

<110>  Centre National de la Recherche Scientifique
       Institut National de la Recherche Medicale
       College de France
 
<120>  Treatment of DNA-damage and age-related diseases or disorders

<130>  F0644/381WO ELMA/safl

<150>  EP15306482.9
<151>  2015-09-23

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  60
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide

<400>  1

Arg Arg Arg Lys Arg Thr Ala Tyr Thr Arg Tyr Gln Leu Leu Glu Leu 
1               5                   10                  15      


Glu Lys Glu Phe Leu Phe Asn Arg Tyr Leu Thr Arg Arg Arg Arg Ile 
            20                  25                  30          


Glu Leu Ala His Ser Leu Asn Leu Thr Glu Arg His Ile Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu Asn 
    50                  55                  60  


<210>  2
<211>  401
<212>  PRT
<213>  Mus musculus

<400>  2

Met Glu Glu Gln Gln Pro Glu Pro Lys Ser Gln Arg Asp Ser Gly Leu 
1               5                   10                  15      


Gly Ala Val Ala Ala Ala Ala Pro Ser Gly Leu Ser Leu Ser Leu Ser 
            20                  25                  30          


Pro Gly Ala Ser Gly Ser Ser Gly Ser Asp Gly Asp Ser Val Pro Val 
        35                  40                  45              


Ser Pro Gln Pro Ala Pro Pro Ser Pro Pro Ala Ala Pro Cys Leu Pro 
    50                  55                  60                  


Pro Leu Ala His His Pro His Leu Pro Pro His Pro Pro Pro Pro Pro 
65                  70                  75                  80  


Pro Pro Pro Pro Pro Pro Pro Gln His Leu Ala Ala Pro Ala His Gln 
                85                  90                  95      


Pro Gln Pro Ala Ala Gln Leu His Arg Thr Thr Asn Phe Phe Ile Asp 
            100                 105                 110         


Asn Ile Leu Arg Pro Asp Phe Gly Cys Lys Lys Glu Gln Pro Leu Pro 
        115                 120                 125             


Gln Leu Leu Val Ala Ser Ala Ala Ala Gly Gly Gly Ala Ala Ala Gly 
    130                 135                 140                 


Gly Gly Ser Arg Val Glu Arg Asp Arg Gly Gln Thr Gly Ala Gly Arg 
145                 150                 155                 160 


Asp Pro Val His Ser Leu Gly Thr Arg Ala Ser Gly Ala Ala Ser Leu 
                165                 170                 175     


Leu Cys Ala Pro Asp Ala Asn Cys Gly Pro Pro Asp Gly Ser Gln Pro 
            180                 185                 190         


Ala Thr Ala Val Gly Ala Gly Ala Ser Lys Ala Gly Asn Pro Ala Ala 
        195                 200                 205             


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Ala Ala Ala 
    210                 215                 220                 


Ala Ala Ala Ala Ser Lys Pro Ser Asp Ser Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Asn Ala Gly Ser Pro Gly Ala Gln Gly Ala Lys Phe Pro Glu His Asn 
                245                 250                 255     


Pro Ala Ile Leu Leu Met Gly Ser Ala Asn Gly Gly Pro Val Val Lys 
            260                 265                 270         


Thr Asp Ser Gln Gln Pro Leu Val Trp Pro Ala Trp Val Tyr Cys Thr 
        275                 280                 285             


Arg Tyr Ser Asp Arg Pro Ser Ser Gly Pro Arg Thr Arg Lys Leu Lys 
    290                 295                 300                 


Lys Lys Lys Asn Glu Lys Glu Asp Lys Arg Pro Arg Thr Ala Phe Thr 
305                 310                 315                 320 


Ala Glu Gln Leu Gln Arg Leu Lys Ala Glu Phe Gln Ala Asn Arg Tyr 
                325                 330                 335     


Ile Thr Glu Gln Arg Arg Gln Thr Leu Ala Gln Glu Leu Ser Leu Asn 
            340                 345                 350         


Glu Ser Gln Ile Lys Ile Trp Phe Gln Asn Lys Arg Ala Lys Ile Lys 
        355                 360                 365             


Lys Ala Thr Gly Ile Lys Asn Gly Leu Ala Leu His Leu Met Ala Gln 
    370                 375                 380                 


Gly Leu Tyr Asn His Ser Thr Thr Thr Val Gln Asp Lys Asp Glu Ser 
385                 390                 395                 400 


Glu 
    


<210>  3
<211>  348
<212>  PRT
<213>  Mus musculus

<400>  3

Met Ser Ala Ala Phe Pro Pro Ser Leu Met Met Met Gln Arg Pro Leu 
1               5                   10                  15      


Gly Ser Ser Thr Ala Phe Ser Ile Asp Ser Leu Ile Gly Ser Pro Pro 
            20                  25                  30          


Gln Pro Ser Pro Gly His Phe Val Tyr Thr Gly Tyr Pro Met Phe Met 
        35                  40                  45              


Pro Tyr Arg Pro Val Val Leu Pro Pro Pro Pro Pro Pro Pro Pro Ala 
    50                  55                  60                  


Leu Pro Gln Ala Ala Leu Gln Pro Ala Leu Pro Pro Ala His Pro His 
65                  70                  75                  80  


His Gln Ile Pro Ser Leu Pro Thr Gly Phe Cys Ser Ser Leu Ala Gln 
                85                  90                  95      


Gly Met Ala Leu Thr Ser Thr Leu Met Ala Thr Leu Pro Gly Gly Phe 
            100                 105                 110         


Ser Ala Ser Pro Gln His Gln Glu Ala Ala Ala Ala Arg Lys Phe Ala 
        115                 120                 125             


Pro Gln Pro Leu Pro Gly Gly Gly Asn Phe Asp Lys Ala Glu Ala Leu 
    130                 135                 140                 


Gln Ala Asp Ala Glu Asp Gly Lys Ala Phe Leu Ala Lys Glu Gly Ser 
145                 150                 155                 160 


Leu Leu Ala Phe Ser Ala Ala Glu Ala Val Gln Ala Ser Leu Val Gly 
                165                 170                 175     


Ala Val Arg Gly Gln Gly Lys Asp Glu Ser Lys Val Glu Asp Asp Pro 
            180                 185                 190         


Lys Gly Lys Glu Glu Ser Phe Ser Leu Glu Ser Asp Val Asp Tyr Ser 
        195                 200                 205             


Ser Asp Asp Asn Leu Pro Gly Gln Thr Ala His Lys Glu Glu Asp Pro 
    210                 215                 220                 


Gly His Ala Leu Glu Glu Thr Pro Gln Ser Gly Gly Ala Ala Gly Ser 
225                 230                 235                 240 


Thr Thr Ser Thr Gly Lys Asn Arg Arg Arg Arg Thr Ala Phe Thr Ser 
                245                 250                 255     


Glu Gln Leu Leu Glu Leu Glu Lys Glu Phe His Cys Lys Lys Tyr Leu 
            260                 265                 270         


Ser Leu Thr Glu Arg Ser Gln Ile Ala His Ala Leu Lys Leu Ser Glu 
        275                 280                 285             


Val Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Ala Lys Trp Lys Arg 
    290                 295                 300                 


Val Lys Ala Gly Asn Ala Asn Ser Lys Thr Gly Glu Pro Ser Arg Asn 
305                 310                 315                 320 


Pro Lys Ile Val Val Pro Ile Pro Val His Val Ser Arg Phe Ala Ile 
                325                 330                 335     


Arg Ser Gln His Gln Gln Leu Glu Gln Ala Arg Pro 
            340                 345             


<210>  4
<211>  397
<212>  PRT
<213>  Mus musculus

<400>  4

Met Glu Ile Val Gly Cys Arg Ala Glu Asn Asn Ser Cys Pro Phe Arg 
1               5                   10                  15      


Pro Pro Ala Met Leu Phe His Gly Ile Ser Gly Gly His Ile Gln Gly 
            20                  25                  30          


Ile Met Glu Glu Met Glu Arg Arg Ser Lys Thr Glu Ala Arg Leu Thr 
        35                  40                  45              


Lys Gly Thr Gln Leu Asn Gly Arg Asp Ala Gly Met Pro Pro Leu Ser 
    50                  55                  60                  


Pro Glu Lys Pro Ala Leu Cys Ala Gly Cys Gly Gly Lys Ile Ser Asp 
65                  70                  75                  80  


Arg Tyr Tyr Leu Leu Ala Val Asp Lys Gln Trp His Leu Arg Cys Leu 
                85                  90                  95      


Lys Cys Cys Glu Cys Lys Leu Ala Leu Glu Ser Glu Leu Thr Cys Phe 
            100                 105                 110         


Ala Lys Asp Gly Ser Ile Tyr Cys Lys Glu Asp Tyr Tyr Arg Arg Phe 
        115                 120                 125             


Ser Val Gln Arg Cys Ala Arg Cys His Leu Gly Ile Ser Ala Ser Glu 
    130                 135                 140                 


Met Val Met Arg Ala Arg Asp Ser Val Tyr His Leu Ser Cys Phe Thr 
145                 150                 155                 160 


Cys Ser Thr Cys Asn Lys Thr Leu Thr Thr Gly Asp His Phe Gly Met 
                165                 170                 175     


Lys Asp Ser Leu Val Tyr Cys Arg Ala His Phe Glu Thr Leu Leu Gln 
            180                 185                 190         


Gly Glu Tyr Pro Pro Gln Leu Ser Tyr Thr Glu Leu Ala Ala Lys Ser 
        195                 200                 205             


Gly Gly Leu Ala Leu Pro Tyr Phe Asn Gly Thr Gly Thr Val Gln Lys 
    210                 215                 220                 


Gly Arg Pro Arg Lys Arg Lys Ser Pro Ala Leu Gly Val Asp Ile Val 
225                 230                 235                 240 


Asn Tyr Asn Ser Gly Cys Asn Glu Asn Glu Ala Asp His Leu Asp Arg 
                245                 250                 255     


Asp Gln Gln Pro Tyr Pro Pro Ser Gln Lys Thr Lys Arg Met Arg Thr 
            260                 265                 270         


Ser Phe Lys His His Gln Leu Arg Thr Met Lys Ser Tyr Phe Ala Ile 
        275                 280                 285             


Asn His Asn Pro Asp Ala Lys Asp Leu Lys Gln Leu Ala Gln Lys Thr 
    290                 295                 300                 


Gly Leu Thr Lys Arg Val Leu Gln Val Trp Phe Gln Asn Ala Arg Ala 
305                 310                 315                 320 


Lys Phe Arg Arg Asn Leu Leu Arg Gln Glu Asn Gly Gly Val Asp Lys 
                325                 330                 335     


Ala Asp Gly Thr Ser Leu Pro Ala Pro Pro Ser Ala Asp Ser Gly Ala 
            340                 345                 350         


Leu Thr Pro Pro Gly Thr Ala Thr Thr Leu Thr Asp Leu Thr Asn Pro 
        355                 360                 365             


Thr Val Thr Val Val Thr Thr Val Thr Ser Asn Met Asp Ser His Glu 
    370                 375                 380                 


Pro Gly Ser Pro Ser Gln Thr Thr Leu Thr Asn Leu Phe 
385                 390                 395         


<210>  5
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  5
tggctcctgg tacatcgaga                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  6
agcattggca accctgagaa                                                   20


<210>  7
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  7
gggcctgctc aggctgt                                                      17


<210>  8
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  8
gttctctgtg ggggatcctg                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  9
ctcgctgcat caggaagacc                                                   20


<210>  10
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  10
taagaggagc aacccgtcg                                                    19


<210>  11
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  11
gccagactat aagccctacc c                                                 21


<210>  12
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  12
gctgcacagg gttacacttc                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  13
ccggtggtca agactgactc                                                   20


<210>  14
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  14
ctggtgcgtg gaccagag                                                     18


<210>  15
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  15
ccttcttcag gtcccaggtc                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  16
aactcagcct tgagcctctg                                                   20


<210>  17
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  17
attcctcttc gccgccatt                                                    19


<210>  18
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  18
gaggcatcga tggccacttt                                                   20


<210>  19
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  19
tctctagagg aacgctgaga cc                                                22


<210>  20
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  20
gtagggtagc ctttgaggga tt                                                22


<210>  21
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  21
cccacctgtc agacccaagt                                                   20


<210>  22
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  22
agtcatagac cagccctgta gca                                               23


<210>  23
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  23
ctgggaactg ccaaagcaac                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  24
cctccgttta cctttcgcca                                                   20


<210>  25
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  25
aatcgacaaa tgggacctaa tga                                               23


<210>  26
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  26
gtaaagatcc tttcccaatc tgttg                                             25


<210>  27
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  27
ggtggaagac aaggaggaag                                                   20


<210>  28
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  28
aggaggagaa aaagccgag                                                    19


<210>  29
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  29
ggcccggaac atctcagg                                                     18


<210>  30
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  30
aaatctgtca ggctggtctg c                                                 21


<210>  31
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  31
ggcgtaaacg cttcgagatg                                                   20


<210>  32
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  32
cttcaggtag ctggagtgag c                                                 21


<210>  33
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  33
gaccccagct tgaagagtcc                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  34
ctgcccatcc agttcgagtt                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  35
ctatccggat gttcgcctcc                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  36
gaggtgacct atctgggggt                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  37
atagcagcag tgagtccagc                                                   20


<210>  38
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  38
gctggctaat tttctgggtt tca                                               23


<210>  39
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  39
cacagcactt gcaggaaagg                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  40
cctgtctggg tgtgtcgatt                                                   20


<210>  41
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  41
cgtgtaagac attcctatct cg                                                22


<210>  42
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  42
gcccgctggc agaacgagaa g                                                 21


<210>  43
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  43
tactgcttag tggccagcct                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  44
aggcatttgc ttgcacacac                                                   20


<210>  45
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  45
gtactggaca gtcctcacac ca                                                22


<210>  46
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  46
ggtggtaccc tatgcattta gc                                                22


<210>  47
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  47
agaggtcaag aagggcaagc                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  48
tgccactcaa cgctctttct                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  49
gcgtggccag tgtaaaagca                                                   20


<210>  50
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  50
cgcattcttc acagatggtg t                                                 21


