               SEQUENCE LISTING

<110> Apogenix AG

<120> SINGLE-CHAIN TL1A RECEPTOR AGONIST PROTEINS

<130> scTL1A-WO

<160> 43

<170> BiSSAP 1.3.6

<210> 1
<211> 251
<212> PRT
<213> Homo sapiens


<220> 
<223> wt-TL1A

<400> 1
Met Ala Glu Asp Leu Gly Leu Ser Phe Gly Glu Thr Ala Ser Val Glu 
1               5                   10                  15      
Met Leu Pro Glu His Gly Ser Cys Arg Pro Lys Ala Arg Ser Ser Ser 
            20                  25                  30          
Ala Arg Trp Ala Leu Thr Cys Cys Leu Val Leu Leu Pro Phe Leu Ala 
        35                  40                  45              
Gly Leu Thr Thr Tyr Leu Leu Val Ser Gln Leu Arg Ala Gln Gly Glu 
    50                  55                  60                  
Ala Cys Val Gln Phe Gln Ala Leu Lys Gly Gln Glu Phe Ala Pro Ser 
65                  70                  75                  80  
His Gln Gln Val Tyr Ala Pro Leu Arg Ala Asp Gly Asp Lys Pro Arg 
                85                  90                  95      
Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln His Phe Lys Asn 
            100                 105                 110         
Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly Leu Ala Phe Thr 
        115                 120                 125             
Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser 
    130                 135                 140                 
Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser 
145                 150                 155                 160 
Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser 
                165                 170                 175     
Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr 
            180                 185                 190         
Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val Gly Ser Asn Trp 
        195                 200                 205             
Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu Gln Glu Gly Asp 
    210                 215                 220                 
Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys 
225                 230                 235                 240 
Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu 
                245                 250     

<210> 2
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 2
Gly Ser Gly Ser Gly Asn Gly Ser 
1               5               

<210> 3
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 3
Gly Ser Gly Ser Gly Ser Gly Ser 
1               5               

<210> 4
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 4
Gly Gly Ser Gly Ser Gly Ser Gly 
1               5               

<210> 5
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 5
Gly Gly Ser Gly Ser Gly 
1               5       

<210> 6
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 6
Gly Gly Ser Gly 
1               

<210> 7
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 7
Gly Gly Ser Gly Asn Gly Ser Gly 
1               5               

<210> 8
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 8
Gly Gly Asn Gly Ser Gly Ser Gly 
1               5               

<210> 9
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 9
Gly Gly Asn Gly Ser Gly 
1               5       

<210> 10
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 10
Gly Ser Gly Ser Gly Ser 
1               5       

<210> 11
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 11
Gly Ser Gly Ser 
1               

<210> 12
<211> 3
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 12
Gly Ser Gly 
1           

<210> 13
<211> 218
<212> PRT
<213> Homo sapiens


<220> 
<223> IGG1 Fc mutein N297S

<400> 13
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
1               5                   10                  15      
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        35                  40                  45              
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    50                  55                  60                  
Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
65                  70                  75                  80  
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                85                  90                  95      
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            100                 105                 110         
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    130                 135                 140                 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
145                 150                 155                 160 
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                165                 170                 175     
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            180                 185                 190         
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        195                 200                 205             
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215             

<210> 14
<211> 217
<212> PRT
<213> Homo sapiens


<220> 
<223> wt-IGG1 Fc

<400> 14
Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      
Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             
Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         

<210> 15
<211> 758
<212> PRT
<213> Artificial Sequence


<220> 
<223> PROTEIN A (TL1A RBDs of Seq39 fused to deglyco Fc)

<400> 15
Met Glu Thr Asp Thr Leu Leu Val Phe Val Leu Leu Val Trp Val Pro 
1               5                   10                  15      
Ala Gly Asn Gly Asp Lys Pro Arg Ala His Leu Thr Val Val Arg Gln 
            20                  25                  30          
Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His Trp Glu 
        35                  40                  45              
His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr Asn 
    50                  55                  60                  
Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln 
65                  70                  75                  80  
Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln Ala 
                85                  90                  95      
Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys Val 
            100                 105                 110         
Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys Ser 
        115                 120                 125             
Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala 
    130                 135                 140                 
Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser Asp 
145                 150                 155                 160 
Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala 
                165                 170                 175     
Phe Leu Leu Gly Ser Gly Ser Gly Asn Gly Ser Pro Arg Ala His Leu 
            180                 185                 190         
Thr Val Val Arg Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro 
        195                 200                 205             
Ala Leu His Trp Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg 
    210                 215                 220                 
Met Asn Tyr Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr 
225                 230                 235                 240 
Phe Ile Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser 
                245                 250                 255     
Glu Ile Arg Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val 
            260                 265                 270         
Val Ile Thr Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu 
        275                 280                 285             
Met Gly Thr Lys Ser Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro 
    290                 295                 300                 
Ile Tyr Leu Gly Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met 
305                 310                 315                 320 
Val Asn Val Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys 
                325                 330                 335     
Thr Phe Phe Gly Ala Phe Leu Leu Gly Ser Gly Ser Pro Arg Ala His 
            340                 345                 350         
Leu Thr Val Val Arg Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe 
        355                 360                 365             
Pro Ala Leu His Trp Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn 
    370                 375                 380                 
Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp 
385                 390                 395                 400 
Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser Glu Cys 
                405                 410                 415     
Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr 
            420                 425                 430         
Val Val Ile Thr Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu 
        435                 440                 445             
Leu Met Gly Thr Lys Ser Val Cys Glu Val Gly Ser Asn Trp Phe Gln 
    450                 455                 460                 
Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu 
465                 470                 475                 480 
Met Val Asn Val Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp 
                485                 490                 495     
Lys Thr Phe Phe Gly Ala Phe Leu Leu Gly Ser Ser Ser Ser Ser Ser 
            500                 505                 510         
Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        515                 520                 525             
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    530                 535                 540                 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
545                 550                 555                 560 
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                565                 570                 575     
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            580                 585                 590         
Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        595                 600                 605             
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    610                 615                 620                 
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
625                 630                 635                 640 
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
                645                 650                 655     
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            660                 665                 670         
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        675                 680                 685             
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    690                 695                 700                 
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
705                 710                 715                 720 
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                725                 730                 735     
Ser Leu Ser Leu Ser Pro Gly Ser Ser Ser Ser Ser Ser Ala Trp Ser 
            740                 745                 750         
His Pro Gln Phe Glu Lys 
        755             

<210> 16
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> hinge linker

<400> 16
Gly Ser Ser Ser Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His 
1               5                   10                  15      
Thr Cys Pro Pro Cys 
            20      

<210> 17
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> universal signal peptide

<400> 17
Met Glu Thr Asp Thr Leu Leu Val Phe Val Leu Leu Val Trp Val Pro 
1               5                   10                  15      
Ala Gly Asn Gly 
            20  

<210> 18
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> serine linker with strep tag

<400> 18
Ser Ser Ser Ser Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
1               5                   10                  15  

<210> 19
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> hinge linker

<400> 19
Gly Ser Ser Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr 
1               5                   10                  15      
Cys Pro Pro Cys 
            20  

<210> 20
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> hinge linker

<400> 20
Gly Ser Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys 
1               5                   10                  15      
Pro Pro Cys 
            

<210> 21
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> hinge linker

<400> 21
Gly Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10                  15      
Pro Cys 
        

<210> 22
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> hinge linker

<400> 22
Gly Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      



<210> 23
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> hinge linker

<400> 23
Gly Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      
Gly Ser 
        

<210> 24
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> hinge linker

<400> 24
Gly Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      
Gly Ser Gly Ser 
            20  

<210> 25
<211> 744
<212> PRT
<213> Artificial Sequence


<220> 
<223> Prot A (Seq15) without strep tag

<400> 25
Met Glu Thr Asp Thr Leu Leu Val Phe Val Leu Leu Val Trp Val Pro 
1               5                   10                  15      
Ala Gly Asn Gly Asp Lys Pro Arg Ala His Leu Thr Val Val Arg Gln 
            20                  25                  30          
Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His Trp Glu 
        35                  40                  45              
His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr Asn 
    50                  55                  60                  
Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln 
65                  70                  75                  80  
Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln Ala 
                85                  90                  95      
Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys Val 
            100                 105                 110         
Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys Ser 
        115                 120                 125             
Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala 
    130                 135                 140                 
Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser Asp 
145                 150                 155                 160 
Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala 
                165                 170                 175     
Phe Leu Leu Gly Ser Gly Ser Gly Asn Gly Ser Pro Arg Ala His Leu 
            180                 185                 190         
Thr Val Val Arg Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro 
        195                 200                 205             
Ala Leu His Trp Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg 
    210                 215                 220                 
Met Asn Tyr Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr 
225                 230                 235                 240 
Phe Ile Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser 
                245                 250                 255     
Glu Ile Arg Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val 
            260                 265                 270         
Val Ile Thr Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu 
        275                 280                 285             
Met Gly Thr Lys Ser Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro 
    290                 295                 300                 
Ile Tyr Leu Gly Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met 
305                 310                 315                 320 
Val Asn Val Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys 
                325                 330                 335     
Thr Phe Phe Gly Ala Phe Leu Leu Gly Ser Gly Ser Pro Arg Ala His 
            340                 345                 350         
Leu Thr Val Val Arg Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe 
        355                 360                 365             
Pro Ala Leu His Trp Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn 
    370                 375                 380                 
Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp 
385                 390                 395                 400 
Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser Glu Cys 
                405                 410                 415     
Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr 
            420                 425                 430         
Val Val Ile Thr Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu 
        435                 440                 445             
Leu Met Gly Thr Lys Ser Val Cys Glu Val Gly Ser Asn Trp Phe Gln 
    450                 455                 460                 
Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu 
465                 470                 475                 480 
Met Val Asn Val Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp 
                485                 490                 495     
Lys Thr Phe Phe Gly Ala Phe Leu Leu Gly Ser Ser Ser Ser Ser Ser 
            500                 505                 510         
Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        515                 520                 525             
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    530                 535                 540                 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
545                 550                 555                 560 
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                565                 570                 575     
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            580                 585                 590         
Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        595                 600                 605             
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    610                 615                 620                 
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
625                 630                 635                 640 
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
                645                 650                 655     
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            660                 665                 670         
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        675                 680                 685             
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    690                 695                 700                 
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
705                 710                 715                 720 
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                725                 730                 735     
Ser Leu Ser Leu Ser Pro Gly Lys 
            740                 

<210> 26
<211> 743
<212> PRT
<213> Artificial Sequence


<220> 
<223> TL1A RBDs of Seq39 (+ signal peptide) fused to wt-Fc of Seq14

<400> 26
Met Glu Thr Asp Thr Leu Leu Val Phe Val Leu Leu Val Trp Val Pro 
1               5                   10                  15      
Ala Gly Asn Gly Asp Lys Pro Arg Ala His Leu Thr Val Val Arg Gln 
            20                  25                  30          
Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His Trp Glu 
        35                  40                  45              
His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr Asn 
    50                  55                  60                  
Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln 
65                  70                  75                  80  
Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln Ala 
                85                  90                  95      
Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys Val 
            100                 105                 110         
Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys Ser 
        115                 120                 125             
Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala 
    130                 135                 140                 
Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser Asp 
145                 150                 155                 160 
Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala 
                165                 170                 175     
Phe Leu Leu Gly Ser Gly Ser Gly Asn Gly Ser Pro Arg Ala His Leu 
            180                 185                 190         
Thr Val Val Arg Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro 
        195                 200                 205             
Ala Leu His Trp Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg 
    210                 215                 220                 
Met Asn Tyr Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr 
225                 230                 235                 240 
Phe Ile Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser 
                245                 250                 255     
Glu Ile Arg Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val 
            260                 265                 270         
Val Ile Thr Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu 
        275                 280                 285             
Met Gly Thr Lys Ser Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro 
    290                 295                 300                 
Ile Tyr Leu Gly Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met 
305                 310                 315                 320 
Val Asn Val Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys 
                325                 330                 335     
Thr Phe Phe Gly Ala Phe Leu Leu Gly Ser Gly Ser Pro Arg Ala His 
            340                 345                 350         
Leu Thr Val Val Arg Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe 
        355                 360                 365             
Pro Ala Leu His Trp Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn 
    370                 375                 380                 
Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp 
385                 390                 395                 400 
Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser Glu Cys 
                405                 410                 415     
Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr 
            420                 425                 430         
Val Val Ile Thr Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu 
        435                 440                 445             
Leu Met Gly Thr Lys Ser Val Cys Glu Val Gly Ser Asn Trp Phe Gln 
    450                 455                 460                 
Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu 
465                 470                 475                 480 
Met Val Asn Val Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp 
                485                 490                 495     
Lys Thr Phe Phe Gly Ala Phe Leu Leu Gly Ser Ser Ser Ser Ser Ser 
            500                 505                 510         
Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        515                 520                 525             
Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    530                 535                 540                 
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
545                 550                 555                 560 
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                565                 570                 575     
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            580                 585                 590         
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        595                 600                 605             
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
    610                 615                 620                 
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
625                 630                 635                 640 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
                645                 650                 655     
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            660                 665                 670         
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        675                 680                 685             
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    690                 695                 700                 
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
705                 710                 715                 720 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                725                 730                 735     
Leu Ser Leu Ser Pro Gly Lys 
            740             

<210> 27
<211> 724
<212> PRT
<213> Artificial Sequence


<220> 
<223> TL1A RBDs of Seq39 fused to deglyco Fc

<400> 27
Asp Lys Pro Arg Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln 
1               5                   10                  15      
His Phe Lys Asn Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly 
            20                  25                  30          
Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu 
        35                  40                  45              
Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg 
    50                  55                  60                  
Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn 
65                  70                  75                  80  
Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr 
                85                  90                  95      
Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val 
            100                 105                 110         
Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu 
        115                 120                 125             
Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val 
    130                 135                 140                 
Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu Gly 
145                 150                 155                 160 
Ser Gly Ser Gly Asn Gly Ser Pro Arg Ala His Leu Thr Val Val Arg 
                165                 170                 175     
Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His Trp 
            180                 185                 190         
Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr 
        195                 200                 205             
Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser 
    210                 215                 220                 
Gln Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln 
225                 230                 235                 240 
Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys 
                245                 250                 255     
Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys 
            260                 265                 270         
Ser Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly 
        275                 280                 285             
Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser 
    290                 295                 300                 
Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly 
305                 310                 315                 320 
Ala Phe Leu Leu Gly Ser Gly Ser Pro Arg Ala His Leu Thr Val Val 
                325                 330                 335     
Arg Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His 
            340                 345                 350         
Trp Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr 
        355                 360                 365             
Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr 
    370                 375                 380                 
Ser Gln Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser Glu Ile Arg 
385                 390                 395                 400 
Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr 
                405                 410                 415     
Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr 
            420                 425                 430         
Lys Ser Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu 
        435                 440                 445             
Gly Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val 
    450                 455                 460                 
Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe 
465                 470                 475                 480 
Gly Ala Phe Leu Leu Gly Ser Ser Ser Ser Ser Ser Ser Ser Gly Ser 
                485                 490                 495     
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            500                 505                 510         
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        515                 520                 525             
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    530                 535                 540                 
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
545                 550                 555                 560 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser Ser Thr 
                565                 570                 575     
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            580                 585                 590         
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
        595                 600                 605             
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    610                 615                 620                 
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
625                 630                 635                 640 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                645                 650                 655     
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            660                 665                 670         
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        675                 680                 685             
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    690                 695                 700                 
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
705                 710                 715                 720 
Ser Pro Gly Lys 
                

<210> 28
<211> 738
<212> PRT
<213> Artificial Sequence


<220> 
<223> TL1A RBDs of Seq39 fused to deglyco Fc (incl. strep tag)

<400> 28
Asp Lys Pro Arg Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln 
1               5                   10                  15      
His Phe Lys Asn Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly 
            20                  25                  30          
Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu 
        35                  40                  45              
Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg 
    50                  55                  60                  
Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn 
65                  70                  75                  80  
Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr 
                85                  90                  95      
Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val 
            100                 105                 110         
Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu 
        115                 120                 125             
Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val 
    130                 135                 140                 
Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu Gly 
145                 150                 155                 160 
Ser Gly Ser Gly Asn Gly Ser Pro Arg Ala His Leu Thr Val Val Arg 
                165                 170                 175     
Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His Trp 
            180                 185                 190         
Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr 
        195                 200                 205             
Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser 
    210                 215                 220                 
Gln Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln 
225                 230                 235                 240 
Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys 
                245                 250                 255     
Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys 
            260                 265                 270         
Ser Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly 
        275                 280                 285             
Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser 
    290                 295                 300                 
Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly 
305                 310                 315                 320 
Ala Phe Leu Leu Gly Ser Gly Ser Pro Arg Ala His Leu Thr Val Val 
                325                 330                 335     
Arg Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His 
            340                 345                 350         
Trp Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr 
        355                 360                 365             
Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr 
    370                 375                 380                 
Ser Gln Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser Glu Ile Arg 
385                 390                 395                 400 
Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr 
                405                 410                 415     
Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr 
            420                 425                 430         
Lys Ser Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu 
        435                 440                 445             
Gly Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val 
    450                 455                 460                 
Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe 
465                 470                 475                 480 
Gly Ala Phe Leu Leu Gly Ser Ser Ser Ser Ser Ser Ser Ser Gly Ser 
                485                 490                 495     
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            500                 505                 510         
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        515                 520                 525             
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    530                 535                 540                 
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
545                 550                 555                 560 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser Ser Thr 
                565                 570                 575     
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            580                 585                 590         
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
        595                 600                 605             
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    610                 615                 620                 
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
625                 630                 635                 640 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                645                 650                 655     
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            660                 665                 670         
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        675                 680                 685             
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    690                 695                 700                 
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
705                 710                 715                 720 
Ser Pro Gly Ser Ser Ser Ser Ser Ser Ala Trp Ser His Pro Gln Phe 
                725                 730                 735     
Glu Lys 
        

<210> 29
<211> 723
<212> PRT
<213> Artificial Sequence


<220> 
<223> TL1A RBDs of Seq39 fused to wt-Fc

<400> 29
Asp Lys Pro Arg Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln 
1               5                   10                  15      
His Phe Lys Asn Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly 
            20                  25                  30          
Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu 
        35                  40                  45              
Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg 
    50                  55                  60                  
Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn 
65                  70                  75                  80  
Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr 
                85                  90                  95      
Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val 
            100                 105                 110         
Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu 
        115                 120                 125             
Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val 
    130                 135                 140                 
Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu Gly 
145                 150                 155                 160 
Ser Gly Ser Gly Asn Gly Ser Pro Arg Ala His Leu Thr Val Val Arg 
                165                 170                 175     
Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His Trp 
            180                 185                 190         
Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr 
        195                 200                 205             
Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser 
    210                 215                 220                 
Gln Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln 
225                 230                 235                 240 
Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys 
                245                 250                 255     
Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys 
            260                 265                 270         
Ser Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly 
        275                 280                 285             
Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser 
    290                 295                 300                 
Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly 
305                 310                 315                 320 
Ala Phe Leu Leu Gly Ser Gly Ser Pro Arg Ala His Leu Thr Val Val 
                325                 330                 335     
Arg Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His 
            340                 345                 350         
Trp Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr 
        355                 360                 365             
Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr 
    370                 375                 380                 
Ser Gln Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser Glu Ile Arg 
385                 390                 395                 400 
Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr 
                405                 410                 415     
Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr 
            420                 425                 430         
Lys Ser Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu 
        435                 440                 445             
Gly Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val 
    450                 455                 460                 
Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe 
465                 470                 475                 480 
Gly Ala Phe Leu Leu Gly Ser Ser Ser Ser Ser Ser Ser Ser Gly Ser 
                485                 490                 495     
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
            500                 505                 510         
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        515                 520                 525             
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    530                 535                 540                 
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
545                 550                 555                 560 
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                565                 570                 575     
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            580                 585                 590         
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
        595                 600                 605             
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    610                 615                 620                 
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
625                 630                 635                 640 
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                645                 650                 655     
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            660                 665                 670         
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        675                 680                 685             
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    690                 695                 700                 
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
705                 710                 715                 720 
Pro Gly Lys 
            

<210> 30
<211> 724
<212> PRT
<213> Artificial Sequence


<220> 
<223> Seq27 mutein with D93Q in RBD 1

<400> 30
Gln Lys Pro Arg Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln 
1               5                   10                  15      
His Phe Lys Asn Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly 
            20                  25                  30          
Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu 
        35                  40                  45              
Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg 
    50                  55                  60                  
Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn 
65                  70                  75                  80  
Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr 
                85                  90                  95      
Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val 
            100                 105                 110         
Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu 
        115                 120                 125             
Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val 
    130                 135                 140                 
Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu Gly 
145                 150                 155                 160 
Ser Gly Ser Gly Asn Gly Ser Pro Arg Ala His Leu Thr Val Val Arg 
                165                 170                 175     
Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His Trp 
            180                 185                 190         
Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr 
        195                 200                 205             
Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser 
    210                 215                 220                 
Gln Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln 
225                 230                 235                 240 
Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys 
                245                 250                 255     
Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys 
            260                 265                 270         
Ser Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly 
        275                 280                 285             
Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser 
    290                 295                 300                 
Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly 
305                 310                 315                 320 
Ala Phe Leu Leu Gly Ser Gly Ser Pro Arg Ala His Leu Thr Val Val 
                325                 330                 335     
Arg Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His 
            340                 345                 350         
Trp Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr 
        355                 360                 365             
Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr 
    370                 375                 380                 
Ser Gln Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser Glu Ile Arg 
385                 390                 395                 400 
Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr 
                405                 410                 415     
Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr 
            420                 425                 430         
Lys Ser Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu 
        435                 440                 445             
Gly Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val 
    450                 455                 460                 
Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe 
465                 470                 475                 480 
Gly Ala Phe Leu Leu Gly Ser Ser Ser Ser Ser Ser Ser Ser Gly Ser 
                485                 490                 495     
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            500                 505                 510         
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        515                 520                 525             
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    530                 535                 540                 
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
545                 550                 555                 560 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser Ser Thr 
                565                 570                 575     
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            580                 585                 590         
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
        595                 600                 605             
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    610                 615                 620                 
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
625                 630                 635                 640 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                645                 650                 655     
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            660                 665                 670         
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        675                 680                 685             
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    690                 695                 700                 
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
705                 710                 715                 720 
Ser Pro Gly Lys 
                

<210> 31
<211> 730
<212> PRT
<213> Artificial Sequence


<220> 
<223> TL1A RBDs of Seq40 fused to deglyco Fc

<400> 31
Asp Lys Pro Arg Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln 
1               5                   10                  15      
His Phe Lys Asn Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly 
            20                  25                  30          
Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu 
        35                  40                  45              
Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg 
    50                  55                  60                  
Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn 
65                  70                  75                  80  
Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr 
                85                  90                  95      
Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val 
            100                 105                 110         
Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu 
        115                 120                 125             
Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val 
    130                 135                 140                 
Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu Gly 
145                 150                 155                 160 
Ser Gly Ser Gly Asn Gly Ser Lys Pro Arg Ala His Leu Thr Val Val 
                165                 170                 175     
Arg Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His 
            180                 185                 190         
Trp Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr 
        195                 200                 205             
Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr 
    210                 215                 220                 
Ser Gln Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser Glu Ile Arg 
225                 230                 235                 240 
Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr 
                245                 250                 255     
Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr 
            260                 265                 270         
Lys Ser Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu 
        275                 280                 285             
Gly Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val 
    290                 295                 300                 
Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe 
305                 310                 315                 320 
Gly Ala Phe Leu Leu Gly Ser Gly Ser Gly Asn Gly Ser Lys Pro Arg 
                325                 330                 335     
Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln His Phe Lys Asn 
            340                 345                 350         
Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly Leu Ala Phe Thr 
        355                 360                 365             
Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser 
    370                 375                 380                 
Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser 
385                 390                 395                 400 
Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser 
                405                 410                 415     
Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr 
            420                 425                 430         
Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val Gly Ser Asn Trp 
        435                 440                 445             
Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu Gln Glu Gly Asp 
    450                 455                 460                 
Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys 
465                 470                 475                 480 
Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu Gly Ser Ser Ser Ser 
                485                 490                 495     
Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            500                 505                 510         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        515                 520                 525             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    530                 535                 540                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
545                 550                 555                 560 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                565                 570                 575     
Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            580                 585                 590         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        595                 600                 605             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    610                 615                 620                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
625                 630                 635                 640 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                645                 650                 655     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            660                 665                 670         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        675                 680                 685             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    690                 695                 700                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
705                 710                 715                 720 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                725                 730 

<210> 32
<211> 721
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein of Seq30 with shorter hinge linker

<400> 32
Gln Lys Pro Arg Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln 
1               5                   10                  15      
His Phe Lys Asn Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly 
            20                  25                  30          
Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu 
        35                  40                  45              
Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg 
    50                  55                  60                  
Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn 
65                  70                  75                  80  
Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr 
                85                  90                  95      
Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val 
            100                 105                 110         
Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu 
        115                 120                 125             
Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val 
    130                 135                 140                 
Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu Gly 
145                 150                 155                 160 
Ser Gly Ser Gly Asn Gly Ser Pro Arg Ala His Leu Thr Val Val Arg 
                165                 170                 175     
Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His Trp 
            180                 185                 190         
Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr 
        195                 200                 205             
Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser 
    210                 215                 220                 
Gln Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln 
225                 230                 235                 240 
Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys 
                245                 250                 255     
Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys 
            260                 265                 270         
Ser Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly 
        275                 280                 285             
Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser 
    290                 295                 300                 
Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly 
305                 310                 315                 320 
Ala Phe Leu Leu Gly Ser Gly Ser Pro Arg Ala His Leu Thr Val Val 
                325                 330                 335     
Arg Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His 
            340                 345                 350         
Trp Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr 
        355                 360                 365             
Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr 
    370                 375                 380                 
Ser Gln Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser Glu Ile Arg 
385                 390                 395                 400 
Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr 
                405                 410                 415     
Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr 
            420                 425                 430         
Lys Ser Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu 
        435                 440                 445             
Gly Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val 
    450                 455                 460                 
Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe 
465                 470                 475                 480 
Gly Ala Phe Leu Leu Gly Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys 
                485                 490                 495     
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            500                 505                 510         
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        515                 520                 525             
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    530                 535                 540                 
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
545                 550                 555                 560 
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser Ser Thr Tyr Arg Val 
                565                 570                 575     
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            580                 585                 590         
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        595                 600                 605             
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    610                 615                 620                 
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
625                 630                 635                 640 
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                645                 650                 655     
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            660                 665                 670         
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        675                 680                 685             
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    690                 695                 700                 
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
705                 710                 715                 720 
Lys 
    

<210> 33
<211> 738
<212> PRT
<213> Artificial Sequence


<220> 
<223> RBD module of seq42 fused to Fc of seq13

<400> 33
Asp Gly Asp Lys Pro Arg Ala His Leu Thr Val Val Arg Gln Thr Pro 
1               5                   10                  15      
Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His Trp Glu His Glu 
            20                  25                  30          
Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe 
        35                  40                  45              
Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr 
    50                  55                  60                  
Phe Arg Gly Met Thr Ser Glu Ser Ser Glu Ile Arg Gln Ala Gly Arg 
65                  70                  75                  80  
Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys Val Thr Asp 
                85                  90                  95      
Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys Ser Val Ser 
            100                 105                 110         
Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe 
        115                 120                 125             
Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser Asp Ile Ser 
    130                 135                 140                 
Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu 
145                 150                 155                 160 
Leu Gly Ser Gly Ser Gly Asn Gly Ser Asp Gly Asp Lys Pro Arg Ala 
                165                 170                 175     
His Leu Thr Val Val Arg Gln Thr Pro Thr Gln His Phe Lys Asn Gln 
            180                 185                 190         
Phe Pro Ala Leu His Trp Glu His Glu Leu Gly Leu Ala Phe Thr Lys 
        195                 200                 205             
Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly 
    210                 215                 220                 
Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser Glu 
225                 230                 235                 240 
Ser Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile 
                245                 250                 255     
Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln 
            260                 265                 270         
Leu Leu Met Gly Thr Lys Ser Val Ser Glu Val Gly Ser Asn Trp Phe 
        275                 280                 285             
Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu Gln Glu Gly Asp Lys 
    290                 295                 300                 
Leu Met Val Asn Val Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu 
305                 310                 315                 320 
Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu Gly Ser Gly Ser Gly Asn 
                325                 330                 335     
Gly Ser Asp Gly Asp Lys Pro Arg Ala His Leu Thr Val Val Arg Gln 
            340                 345                 350         
Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His Trp Glu 
        355                 360                 365             
His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr Asn 
    370                 375                 380                 
Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln 
385                 390                 395                 400 
Val Thr Phe Arg Gly Met Thr Ser Glu Ser Ser Glu Ile Arg Gln Ala 
                405                 410                 415     
Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys Val 
            420                 425                 430         
Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys Ser 
        435                 440                 445             
Val Ser Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala 
    450                 455                 460                 
Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser Asp 
465                 470                 475                 480 
Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala 
                485                 490                 495     
Phe Leu Leu Gly Ser Ser Ser Ser Ser Ser Ser Ser Gly Ser Cys Asp 
            500                 505                 510         
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        515                 520                 525             
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    530                 535                 540                 
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
545                 550                 555                 560 
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                565                 570                 575     
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser Ser Thr Tyr Arg 
            580                 585                 590         
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        595                 600                 605             
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    610                 615                 620                 
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
625                 630                 635                 640 
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
                645                 650                 655     
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            660                 665                 670         
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        675                 680                 685             
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    690                 695                 700                 
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
705                 710                 715                 720 
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                725                 730                 735     
Gly Lys 
        

<210> 34
<211> 721
<212> PRT
<213> Artificial Sequence


<220> 
<223> Protein A with shorter hinge linker

<400> 34
Asp Lys Pro Arg Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln 
1               5                   10                  15      
His Phe Lys Asn Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly 
            20                  25                  30          
Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu 
        35                  40                  45              
Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg 
    50                  55                  60                  
Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn 
65                  70                  75                  80  
Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr 
                85                  90                  95      
Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val 
            100                 105                 110         
Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu 
        115                 120                 125             
Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val 
    130                 135                 140                 
Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu Gly 
145                 150                 155                 160 
Ser Gly Ser Gly Asn Gly Ser Pro Arg Ala His Leu Thr Val Val Arg 
                165                 170                 175     
Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His Trp 
            180                 185                 190         
Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr 
        195                 200                 205             
Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser 
    210                 215                 220                 
Gln Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln 
225                 230                 235                 240 
Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys 
                245                 250                 255     
Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys 
            260                 265                 270         
Ser Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly 
        275                 280                 285             
Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser 
    290                 295                 300                 
Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly 
305                 310                 315                 320 
Ala Phe Leu Leu Gly Ser Gly Ser Pro Arg Ala His Leu Thr Val Val 
                325                 330                 335     
Arg Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His 
            340                 345                 350         
Trp Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr 
        355                 360                 365             
Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr 
    370                 375                 380                 
Ser Gln Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser Glu Ile Arg 
385                 390                 395                 400 
Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr 
                405                 410                 415     
Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr 
            420                 425                 430         
Lys Ser Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu 
        435                 440                 445             
Gly Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val 
    450                 455                 460                 
Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe 
465                 470                 475                 480 
Gly Ala Phe Leu Leu Gly Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys 
                485                 490                 495     
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            500                 505                 510         
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        515                 520                 525             
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    530                 535                 540                 
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
545                 550                 555                 560 
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser Ser Thr Tyr Arg Val 
                565                 570                 575     
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            580                 585                 590         
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        595                 600                 605             
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    610                 615                 620                 
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
625                 630                 635                 640 
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                645                 650                 655     
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            660                 665                 670         
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        675                 680                 685             
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    690                 695                 700                 
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
705                 710                 715                 720 
Lys 
    

<210> 35
<211> 724
<212> PRT
<213> Artificial Sequence


<220> 
<223> mature Prot A - mutein C162S and C202S

<400> 35
Asp Lys Pro Arg Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln 
1               5                   10                  15      
His Phe Lys Asn Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly 
            20                  25                  30          
Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu 
        35                  40                  45              
Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg 
    50                  55                  60                  
Gly Met Thr Ser Glu Ser Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn 
65                  70                  75                  80  
Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr 
                85                  90                  95      
Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys Ser Val Ser Glu Val 
            100                 105                 110         
Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu 
        115                 120                 125             
Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val 
    130                 135                 140                 
Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu Gly 
145                 150                 155                 160 
Ser Gly Ser Gly Asn Gly Ser Pro Arg Ala His Leu Thr Val Val Arg 
                165                 170                 175     
Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His Trp 
            180                 185                 190         
Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr 
        195                 200                 205             
Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser 
    210                 215                 220                 
Gln Val Thr Phe Arg Gly Met Thr Ser Glu Ser Ser Glu Ile Arg Gln 
225                 230                 235                 240 
Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys 
                245                 250                 255     
Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys 
            260                 265                 270         
Ser Val Ser Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly 
        275                 280                 285             
Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser 
    290                 295                 300                 
Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly 
305                 310                 315                 320 
Ala Phe Leu Leu Gly Ser Gly Ser Pro Arg Ala His Leu Thr Val Val 
                325                 330                 335     
Arg Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His 
            340                 345                 350         
Trp Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr 
        355                 360                 365             
Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr 
    370                 375                 380                 
Ser Gln Val Thr Phe Arg Gly Met Thr Ser Glu Ser Ser Glu Ile Arg 
385                 390                 395                 400 
Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr 
                405                 410                 415     
Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr 
            420                 425                 430         
Lys Ser Val Ser Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu 
        435                 440                 445             
Gly Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val 
    450                 455                 460                 
Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe 
465                 470                 475                 480 
Gly Ala Phe Leu Leu Gly Ser Ser Ser Ser Ser Ser Ser Ser Gly Ser 
                485                 490                 495     
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            500                 505                 510         
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        515                 520                 525             
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    530                 535                 540                 
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
545                 550                 555                 560 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser Ser Thr 
                565                 570                 575     
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            580                 585                 590         
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
        595                 600                 605             
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    610                 615                 620                 
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
625                 630                 635                 640 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                645                 650                 655     
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            660                 665                 670         
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        675                 680                 685             
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    690                 695                 700                 
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
705                 710                 715                 720 
Ser Pro Gly Lys 
                

<210> 36
<211> 487
<212> PRT
<213> Artificial Sequence


<220> 
<223> Exemplary scTL1A-RBD module

<400> 36
Asp Gly Asp Lys Pro Arg Ala His Leu Thr Val Val Arg Gln Thr Pro 
1               5                   10                  15      
Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His Trp Glu His Glu 
            20                  25                  30          
Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe 
        35                  40                  45              
Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr 
    50                  55                  60                  
Phe Arg Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg 
65                  70                  75                  80  
Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys Val Thr Asp 
                85                  90                  95      
Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys Ser Val Cys 
            100                 105                 110         
Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe 
        115                 120                 125             
Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser Asp Ile Ser 
    130                 135                 140                 
Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu 
145                 150                 155                 160 
Leu Gly Ser Gly Ser Gly Asn Gly Ser Pro Arg Ala His Leu Thr Val 
                165                 170                 175     
Val Arg Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu 
            180                 185                 190         
His Trp Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn 
        195                 200                 205             
Tyr Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile 
    210                 215                 220                 
Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser Glu Ile 
225                 230                 235                 240 
Arg Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile 
                245                 250                 255     
Thr Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly 
            260                 265                 270         
Thr Lys Ser Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr 
        275                 280                 285             
Leu Gly Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn 
    290                 295                 300                 
Val Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe 
305                 310                 315                 320 
Phe Gly Ala Phe Leu Leu Gly Ser Gly Ser Pro Arg Ala His Leu Thr 
                325                 330                 335     
Val Val Arg Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala 
            340                 345                 350         
Leu His Trp Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met 
        355                 360                 365             
Asn Tyr Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe 
    370                 375                 380                 
Ile Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser Glu 
385                 390                 395                 400 
Ile Arg Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val 
                405                 410                 415     
Ile Thr Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met 
            420                 425                 430         
Gly Thr Lys Ser Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro Ile 
        435                 440                 445             
Tyr Leu Gly Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val 
    450                 455                 460                 
Asn Val Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr 
465                 470                 475                 480 
Phe Phe Gly Ala Phe Leu Leu 
                485         

<210> 37
<211> 2279
<212> DNA
<213> Artificial Sequence


<220> 
<223> DNA encoding ORF of Seq25

<400> 37
aagctttagg gataacaggg taatagccgc caccatggag actgacaccc tgctggtgtt      60

cgtgctgctg gtctgggtgc ctgcaggaaa tggagacaag ccaagagcac acttgaccgt     120

ggtgcgacag acacctaccc agcattttaa gaatcaattc cctgctctcc actgggagca     180

cgagctgggt ctggccttta caaagaacag aatgaactac actaacaaat ttctgctgat     240

ccctgaatct ggggattatt tcatctattc tcaggtgaca tttcggggaa tgacttcaga     300

gtgctcagaa attcgtcagg ctggaaggcc taataagccc gacagcatca cggtcgttat     360

taccaaagtg acagattctt atccagaacc aactcagctg ctgatgggta ccaagagcgt     420

ttgcgaagtg ggcagcaact ggttccagcc catctatctg ggtgctatgt tttctctgca     480

agagggcgat aaactcatgg tcaatgtgag tgacatttct cttgtggatt acactaagga     540

ggataagacc ttcttcggtg cattcctgct gggctcagga tctggcaatg ggagtcctag     600

agcccatctc acagtcgtga ggcagacccc aactcagcac ttcaagaacc agttccccgc     660

cctgcattgg gagcacgaac tgggtcttgc attcaccaag aacaggatga attacaccaa     720

taagttcctg ttgatacccg aatccggaga ctactttatc tactcccaag tcacctttcg     780

cggcatgact tctgaatgca gcgaaatccg gcaggctggt cgccccaaca agcccgattc     840

catcactgta gtgatcacca aggtaacaga cagctaccct gaacccacgc agctcctcat     900

gggcaccaaa agtgtgtgtg aagtcggcag caattggttt cagcccattt atctcggcgc     960

catgttttca cttcaggagg gtgataaact gatggtcaac gtttccgaca ttagcctcgt    1020

tgactacaca aaggaagata aaactttctt cggggctttc ctgctggggt ccggaagtcc    1080

ccgagcccac ttgacagtcg ttcgtcaaac gccaacacag cactttaaga atcagtttcc    1140

agcccttcat tgggagcatg agttggggct ggcatttact aagaatcgca tgaactatac    1200

caacaaattc ctgctgatcc cagagagtgg ggattacttt atctacagcc aagtgacatt    1260

tcgaggcatg actagcgagt gttccgagat tcggcaggcc ggaaggccca acaagcctga    1320

ttccattacc gtggtcataa ctaaggtaac agactcctat ccagagccta cccagctttt    1380

gatggggacc aaatccgttt gtgaggtggg ctcaaactgg tttcaaccca tataccttgg    1440

agccatgttc tccttgcagg agggagacaa actgatggtg aatgtgtctg acatcagtct    1500

ggtagactat accaaagagg acaaaacatt ctttggcgct ttcctcctgg gatcctcgag    1560

ttcatcgtcc tcatccggct catgtgataa gacccacacc tgccctccct gtcctgcccc    1620

tgagctgctg ggcggacctt ctgtgttcct gttccccccc aagcctaagg acaccctgat    1680

gatctccagg acccctgagg tgacctgtgt ggtggtggac gtgtctcacg aagatcccga    1740

ggtgaagttc aactggtacg tggacggcgt ggaggtccac aacgccaaga ccaagcctag    1800

ggaggagcag tacagctcca cctaccgggt ggtgtctgtg ctgaccgtgc tgcaccagga    1860

ttggctgaac ggaaaggagt ataagtgtaa ggtctccaac aaggccctgc ctgcccccat    1920

cgagaaaacc atctccaagg ccaagggcca gcctcgggag cctcaggtgt acaccctgcc    1980

tcctagcagg gaggagatga ccaagaacca ggtgtccctg acctgtctgg tgaagggctt    2040

ctacccttcc gatatcgccg tggagtggga gtctaatggc cagcccgaga acaactacaa    2100

gaccacccct cctgtgctgg actctgacgg ctccttcttc ctgtactcca agctgaccgt    2160

ggacaagtcc agatggcagc agggcaacgt gttctcctgc tccgtgatgc acgaggccct    2220

gcacaatcac tacacccaga agtccctgtc tctgagtccg ggcaagtaat aggcgcgcc     2279


<210> 38
<211> 231
<212> PRT
<213> Artificial Sequence


<220> 
<223> Protein X: TL1A-RBD fused to RB69-FOLDON

<400> 38
Met Glu Thr Asp Thr Leu Leu Val Phe Val Leu Leu Val Trp Val Asp 
1               5                   10                  15      
Lys Pro Arg Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln His 
            20                  25                  30          
Phe Lys Asn Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly Leu 
        35                  40                  45              
Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu Ile 
    50                  55                  60                  
Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg Gly 
65                  70                  75                  80  
Met Thr Ser Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn Lys 
                85                  90                  95      
Pro Asp Ser Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr Pro 
            100                 105                 110         
Glu Pro Thr Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val Gly 
        115                 120                 125             
Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu Gln 
    130                 135                 140                 
Glu Gly Asp Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val Asp 
145                 150                 155                 160 
Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu Gly Ser 
                165                 170                 175     
Gly Ser Ser Gly Ser Ser Gly Ser Ser Gly Ser Gly Tyr Ile Glu Asp 
            180                 185                 190         
Ala Pro Ser Asp Gly Lys Phe Tyr Val Arg Lys Asp Gly Ala Trp Val 
        195                 200                 205             
Glu Leu Pro Thr Ala Ser Gly Pro Ser Ser Ser Ser Ser Ser Ala Trp 
    210                 215                 220                 
Ser His Pro Gln Phe Glu Lys 
225                 230     

<210> 39
<211> 485
<212> PRT
<213> Artificial Sequence


<220> 
<223> Exemplary scTL1A-RBD module

<400> 39
Asp Lys Pro Arg Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln 
1               5                   10                  15      
His Phe Lys Asn Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly 
            20                  25                  30          
Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu 
        35                  40                  45              
Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg 
    50                  55                  60                  
Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn 
65                  70                  75                  80  
Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr 
                85                  90                  95      
Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val 
            100                 105                 110         
Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu 
        115                 120                 125             
Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val 
    130                 135                 140                 
Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu Gly 
145                 150                 155                 160 
Ser Gly Ser Gly Asn Gly Ser Pro Arg Ala His Leu Thr Val Val Arg 
                165                 170                 175     
Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His Trp 
            180                 185                 190         
Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr 
        195                 200                 205             
Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser 
    210                 215                 220                 
Gln Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln 
225                 230                 235                 240 
Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys 
                245                 250                 255     
Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys 
            260                 265                 270         
Ser Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly 
        275                 280                 285             
Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser 
    290                 295                 300                 
Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly 
305                 310                 315                 320 
Ala Phe Leu Leu Gly Ser Gly Ser Pro Arg Ala His Leu Thr Val Val 
                325                 330                 335     
Arg Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His 
            340                 345                 350         
Trp Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr 
        355                 360                 365             
Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr 
    370                 375                 380                 
Ser Gln Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser Glu Ile Arg 
385                 390                 395                 400 
Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr 
                405                 410                 415     
Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr 
            420                 425                 430         
Lys Ser Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu 
        435                 440                 445             
Gly Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val 
    450                 455                 460                 
Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe 
465                 470                 475                 480 
Gly Ala Phe Leu Leu 
                485 

<210> 40
<211> 491
<212> PRT
<213> Artificial Sequence


<220> 
<223> Exemplary scTL1A-RBD module

<400> 40
Asp Lys Pro Arg Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln 
1               5                   10                  15      
His Phe Lys Asn Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly 
            20                  25                  30          
Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu 
        35                  40                  45              
Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg 
    50                  55                  60                  
Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn 
65                  70                  75                  80  
Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr 
                85                  90                  95      
Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val 
            100                 105                 110         
Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu 
        115                 120                 125             
Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val 
    130                 135                 140                 
Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu Gly 
145                 150                 155                 160 
Ser Gly Ser Gly Asn Gly Ser Lys Pro Arg Ala His Leu Thr Val Val 
                165                 170                 175     
Arg Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His 
            180                 185                 190         
Trp Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr 
        195                 200                 205             
Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr 
    210                 215                 220                 
Ser Gln Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser Glu Ile Arg 
225                 230                 235                 240 
Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr 
                245                 250                 255     
Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr 
            260                 265                 270         
Lys Ser Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu 
        275                 280                 285             
Gly Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val 
    290                 295                 300                 
Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe 
305                 310                 315                 320 
Gly Ala Phe Leu Leu Gly Ser Gly Ser Gly Asn Gly Ser Lys Pro Arg 
                325                 330                 335     
Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln His Phe Lys Asn 
            340                 345                 350         
Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly Leu Ala Phe Thr 
        355                 360                 365             
Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser 
    370                 375                 380                 
Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser 
385                 390                 395                 400 
Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser 
                405                 410                 415     
Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr 
            420                 425                 430         
Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val Gly Ser Asn Trp 
        435                 440                 445             
Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu Gln Glu Gly Asp 
    450                 455                 460                 
Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys 
465                 470                 475                 480 
Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu 
                485                 490     

<210> 41
<211> 499
<212> PRT
<213> Artificial Sequence


<220> 
<223> Exemplary scTL1A-RBD module

<400> 41
Asp Gly Asp Lys Pro Arg Ala His Leu Thr Val Val Arg Gln Thr Pro 
1               5                   10                  15      
Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His Trp Glu His Glu 
            20                  25                  30          
Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe 
        35                  40                  45              
Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr 
    50                  55                  60                  
Phe Arg Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg 
65                  70                  75                  80  
Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys Val Thr Asp 
                85                  90                  95      
Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys Ser Val Cys 
            100                 105                 110         
Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe 
        115                 120                 125             
Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser Asp Ile Ser 
    130                 135                 140                 
Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu 
145                 150                 155                 160 
Leu Gly Ser Gly Ser Gly Asn Gly Ser Asp Gly Asp Lys Pro Arg Ala 
                165                 170                 175     
His Leu Thr Val Val Arg Gln Thr Pro Thr Gln His Phe Lys Asn Gln 
            180                 185                 190         
Phe Pro Ala Leu His Trp Glu His Glu Leu Gly Leu Ala Phe Thr Lys 
        195                 200                 205             
Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly 
    210                 215                 220                 
Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser Glu 
225                 230                 235                 240 
Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile 
                245                 250                 255     
Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln 
            260                 265                 270         
Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val Gly Ser Asn Trp Phe 
        275                 280                 285             
Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu Gln Glu Gly Asp Lys 
    290                 295                 300                 
Leu Met Val Asn Val Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu 
305                 310                 315                 320 
Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu Gly Ser Gly Ser Gly Asn 
                325                 330                 335     
Gly Ser Asp Gly Asp Lys Pro Arg Ala His Leu Thr Val Val Arg Gln 
            340                 345                 350         
Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His Trp Glu 
        355                 360                 365             
His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr Asn 
    370                 375                 380                 
Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln 
385                 390                 395                 400 
Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln Ala 
                405                 410                 415     
Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys Val 
            420                 425                 430         
Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys Ser 
        435                 440                 445             
Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala 
    450                 455                 460                 
Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser Asp 
465                 470                 475                 480 
Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala 
                485                 490                 495     
Phe Leu Leu 
            

<210> 42
<211> 499
<212> PRT
<213> Artificial Sequence


<220> 
<223> Exemplary scTL1A-RBD module

<400> 42
Asp Gly Asp Lys Pro Arg Ala His Leu Thr Val Val Arg Gln Thr Pro 
1               5                   10                  15      
Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His Trp Glu His Glu 
            20                  25                  30          
Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe 
        35                  40                  45              
Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr 
    50                  55                  60                  
Phe Arg Gly Met Thr Ser Glu Ser Ser Glu Ile Arg Gln Ala Gly Arg 
65                  70                  75                  80  
Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys Val Thr Asp 
                85                  90                  95      
Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys Ser Val Ser 
            100                 105                 110         
Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe 
        115                 120                 125             
Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser Asp Ile Ser 
    130                 135                 140                 
Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu 
145                 150                 155                 160 
Leu Gly Ser Gly Ser Gly Asn Gly Ser Asp Gly Asp Lys Pro Arg Ala 
                165                 170                 175     
His Leu Thr Val Val Arg Gln Thr Pro Thr Gln His Phe Lys Asn Gln 
            180                 185                 190         
Phe Pro Ala Leu His Trp Glu His Glu Leu Gly Leu Ala Phe Thr Lys 
        195                 200                 205             
Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly 
    210                 215                 220                 
Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser Glu 
225                 230                 235                 240 
Ser Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile 
                245                 250                 255     
Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln 
            260                 265                 270         
Leu Leu Met Gly Thr Lys Ser Val Ser Glu Val Gly Ser Asn Trp Phe 
        275                 280                 285             
Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu Gln Glu Gly Asp Lys 
    290                 295                 300                 
Leu Met Val Asn Val Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu 
305                 310                 315                 320 
Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu Gly Ser Gly Ser Gly Asn 
                325                 330                 335     
Gly Ser Asp Gly Asp Lys Pro Arg Ala His Leu Thr Val Val Arg Gln 
            340                 345                 350         
Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His Trp Glu 
        355                 360                 365             
His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr Asn 
    370                 375                 380                 
Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln 
385                 390                 395                 400 
Val Thr Phe Arg Gly Met Thr Ser Glu Ser Ser Glu Ile Arg Gln Ala 
                405                 410                 415     
Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys Val 
            420                 425                 430         
Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys Ser 
        435                 440                 445             
Val Ser Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala 
    450                 455                 460                 
Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser Asp 
465                 470                 475                 480 
Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala 
                485                 490                 495     
Phe Leu Leu 
            

<210> 43
<211> 485
<212> PRT
<213> Artificial Sequence


<220> 
<223> Exemplary scTL1A-RBD module

<400> 43
Asp Lys Pro Arg Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln 
1               5                   10                  15      
His Phe Lys Asn Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly 
            20                  25                  30          
Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu 
        35                  40                  45              
Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg 
    50                  55                  60                  
Gly Met Thr Ser Glu Ser Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn 
65                  70                  75                  80  
Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr 
                85                  90                  95      
Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys Ser Val Ser Glu Val 
            100                 105                 110         
Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu 
        115                 120                 125             
Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val 
    130                 135                 140                 
Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu Gly 
145                 150                 155                 160 
Ser Gly Ser Gly Asn Gly Ser Pro Arg Ala His Leu Thr Val Val Arg 
                165                 170                 175     
Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His Trp 
            180                 185                 190         
Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr 
        195                 200                 205             
Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser 
    210                 215                 220                 
Gln Val Thr Phe Arg Gly Met Thr Ser Glu Ser Ser Glu Ile Arg Gln 
225                 230                 235                 240 
Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys 
                245                 250                 255     
Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys 
            260                 265                 270         
Ser Val Ser Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly 
        275                 280                 285             
Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser 
    290                 295                 300                 
Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly 
305                 310                 315                 320 
Ala Phe Leu Leu Gly Ser Gly Ser Pro Arg Ala His Leu Thr Val Val 
                325                 330                 335     
Arg Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His 
            340                 345                 350         
Trp Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr 
        355                 360                 365             
Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr 
    370                 375                 380                 
Ser Gln Val Thr Phe Arg Gly Met Thr Ser Glu Ser Ser Glu Ile Arg 
385                 390                 395                 400 
Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr 
                405                 410                 415     
Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr 
            420                 425                 430         
Lys Ser Val Ser Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu 
        435                 440                 445             
Gly Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val 
    450                 455                 460                 
Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe 
465                 470                 475                 480 
Gly Ala Phe Leu Leu 
                485 

