                         SEQUENCE LISTING

<110>  Mayo Foundation for Medical Education and Research
 
<120>  ANTIBODIES TO B7-H1

<130>  07039-1513WO1

<140>  PCT/US2016/058852
<141>  2016-10-26

<150>  US 62/248,956
<151>  2015-10-30

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B11: Heavy chain amino acids sequence

<400>  1

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Met Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe 
        35                  40                  45              


Ser Asn Tyr Trp Ile Glu Trp Ile Lys Gln Arg Pro Gly His Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Leu Pro Gly Gly Gly Asn Pro Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Arg Ala Val Asp Ser Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro 
    130                 135                 140                 


Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn 
                165                 170                 175     


Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr 
        195                 200                 205             


Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser 
    210                 215                 220                 


Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro 
225                 230                 235                 240 


Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu 
            260                 265                 270         


Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro 
        275                 280                 285             


Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala 
    290                 295                 300                 


Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val 
305                 310                 315                 320 


Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe 
                325                 330                 335     


Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr 
            340                 345                 350         


Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu 
        355                 360                 365             


Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys 
    370                 375                 380                 


Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn 
385                 390                 395                 400 


Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys 
            420                 425                 430         


Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly 
        435                 440                 445             


Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
    450                 455                 460                 


<210>  2
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region of the B11 monoclonal antibody

<400>  2

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Ile Glu Trp Ile Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Gly Gly Asn Pro Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Ala Val Asp Ser Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of the heavy chain variable region of the B11 monoclonal 
       antibody

<400>  3

Asn Tyr Trp Ile Glu 
1               5   


<210>  4
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of the heavy chain variable region of the B11 monoclonal 
       antibody

<400>  4

Glu Ile Leu Pro Gly Gly Gly Asn Pro Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly Lys 
        


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the heavy chain variable region of the B11 monoclonal 
       antibody

<400>  5

Glu Arg Ala Val Asp Ser 
1               5       


<210>  6
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B11: Light chain amino acids sequence

<400>  6

Met Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Gln Met Ile Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Thr Ser Ser Leu Arg Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser 
            100                 105                 110         


Lys Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 


<210>  7
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region of the B11 human monoclonal antibody

<400>  7

Asp Ile Gln Met Ile Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of the light chain variable region of the B11 human 
       monoclonal antibody

<400>  8

Ser Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of the light chain variable region of the B11 human 
       monoclonal antibody

<400>  9

Tyr Thr Ser Ser Leu Arg Ser 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the light chain variable region of the B11 human 
       monoclonal antibody

<400>  10

Gln Gln Tyr Ser Lys Leu Pro Trp Thr 
1               5                   


<210>  11
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H1A: Heavy chain amino acids sequence

<400>  11

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ser Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gln Leu Val Arg 
            20                  25                  30          


Pro Gly Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Asn Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Met Ile Asp Pro Ser Asp Ser Glu Thr Arg Leu Ser 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr 
                85                  90                  95      


Thr Ala Tyr Met Gln Phe Ser Ser Pro Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Ser Asp Lys Phe Asp Gly Tyr Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr 
    130                 135                 140                 


Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly 
145                 150                 155                 160 


Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
        195                 200                 205             


Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg 
225                 230                 235                 240 


Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp 
            260                 265                 270         


Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn 
    290                 295                 300                 


Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn 
305                 310                 315                 320 


Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp 
                325                 330                 335     


Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala 
        355                 360                 365             


Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys 
    370                 375                 380                 


Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile 
385                 390                 395                 400 


Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn 
                405                 410                 415     


Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys 
            420                 425                 430         


Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys 
        435                 440                 445             


Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe 
    450                 455                 460                 


Ser Arg Thr Pro Gly Lys 
465                 470 


<210>  12
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region of the H1A monoclonal antibody

<400>  12

Gln Val Gln Leu Gln Gln Ser Gly Pro Gln Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Asn 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Ser Glu Thr Arg Leu Ser Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Phe Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Asp Lys Phe Asp Gly Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of the heavy chain variable region of the H1A monoclonal 
       antibody

<400>  13

Asp Asn Trp Met His 
1               5   


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of the heavy chain variable region of the H1A monoclonal 
       antibody

<400>  14

Met Ile Asp Pro Ser Asp Ser Glu Thr Arg Leu Ser Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  15
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 3 of the the heavy chain variable region of the H1A 
       monoclonal antibody

<400>  15

Ser Asp Lys Phe Asp Gly Tyr Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  16
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H1A: Light chain amino acids sequence

<400>  16

Met Arg Pro Ser Ile Gln Phe Leu Gly Leu Leu Leu Phe Trp Leu His 
1               5                   10                  15      


Gly Ala Gln Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Ile Asp Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro 
    50                  55                  60                  


Arg Leu Leu Ile His His Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Phe Ser Phe Ser Ile Ser 
                85                  90                  95      


Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp 
            100                 105                 110         


Tyr Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
        115                 120                 125             


Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu 
    130                 135                 140                 


Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn 
                165                 170                 175     


Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His 
        195                 200                 205             


Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile 
    210                 215                 220                 


Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230             


<210>  17
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region of the H1A monoclonal antibody

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asp Lys Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile 
        35                  40                  45              


His His Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Phe Ser Phe Ser Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Tyr Leu Arg Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of the light chain variable region of the H1A monoclonal 
       antibody

<400>  18

Lys Ala Ser Gln Asp Ile Asp Lys Tyr Ile Ala 
1               5                   10      


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of the light chain variable region of the H1A monoclonal 
       antibody

<400>  19

His Thr Ser Thr Leu Gln Pro 
1               5           


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the light chain variable region of the H1A monoclonal 
       antibody

<400>  20

Leu Gln Tyr Asp Tyr Leu Arg Thr 
1               5               


<210>  21
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B11: Heavy chain DNA sequence

<400>  21
atggaatgga cctgggtctt tctcttcctc ctgtcagtaa ctgcaggtgt ccactcccag       60

gttcagctgc agcagtctgg acctgaactg atgaagcctg gggcctcagt gaagatatcc      120

tgcaaggcta ctggctacac attcagtaac tactggatag agtggataaa acagaggcct      180

ggacatggcc ttgagtggat tggagagatt ttacctggag gtggtaatcc taactacaat      240

gagaagttca agggcaaggc cacattcact gcagatacat cctccaacac agcctacatg      300

catctcagca gcctgacatc tgaggactct gccgtctatt actgtgcaag ggagagggct      360

gtggactcct ggggtcaagg aacctcagtc accgtctcct cagccaaaac aacagcccca      420

tcggtctatc cactggcccc tgtgtgtgga gatacaactg gctcctcggt gactctagga      480

tgcctggtca agggttattt ccctgagcca gtgaccttga cctggaactc tggatccctg      540

tccagtggtg tgcacacctt cccagctgtc ctgcagtctg acctctacac cctcagcagc      600

tcagtgactg taacctcgag cacctggccc agccagtcca tcacctgcaa tgtggcccac      660

ccggcaagca gcaccaaggt ggacaagaaa attgagccca gagggcccac aatcaagccc      720

tgtcctccat gcaaatgccc agcacctaac ctcttgggtg gaccatccgt cttcatcttc      780

cctccaaaga tcaaggatgt actcatgatc tccctgagcc ccatagtcac atgtgtggtg      840

gtggatgtga gcgaggatga cccagatgtc cagatcagct ggtttgtgaa caacgtggaa      900

gtacacacag ctcagacaca aacccataga gaggattaca acagtactct ccgggtggtc      960

agtgccctcc ccatccagca ccaggactgg atgagtggca aggagttcaa atgcaaggtc     1020

aacaacaaag acctcccagc gcccatcgag agaaccatct caaaacccaa agggtcagta     1080

agagctccac aggtatatgt cttgcctcca ccagaagaag agatgactaa gaaacaggtc     1140

actctgacct gcatggtcac agacttcatg cctgaagaca tttacgtgga gtggaccaac     1200

aacgggaaaa cagagctaaa ctacaagaac actgaaccag tcctggactc tgatggttct     1260

tacttcatgt acagcaagct gagagtggaa aagaagaact gggtggaaag aaatagctac     1320

tcctgttcag tggtccacga gggtctgcac aatcaccaca cgactaagag cttctcccgg     1380

actccgggta aatga                                                      1395


<210>  22
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region of the B11 monoclonal antibody

<400>  22
caggttcagc tgcagcagtc tggacctgaa ctgatgaagc ctggggcctc agtgaagata       60

tcctgcaagg ctactggcta cacattcagt aactactgga tagagtggat aaaacagagg      120

cctggacatg gccttgagtg gattggagag attttacctg gaggtggtaa tcctaactac      180

aatgagaagt tcaagggcaa ggccacattc actgcagata catcctccaa cacagcctac      240

atgcatctca gcagcctgac atctgaggac tctgccgtct attactgtgc aagggagagg      300

gctgtggact cctggggtca aggaacctca gtcaccgtct cctca                      345


<210>  23
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B11: Light chain DNA sequence

<400>  23
atgatgtcct ctgctcagtt ccttggtctc ctgttgctct gttttcaagg taccagatgt       60

gatatccaga tgatacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc      120

atcagttgca gtgcaagtca ggacattagc aattatttaa actggtatca gcaaaaacca      180

gatggaactg ttaaactcct gatctattac acatccagtt tacgctcagg agtcccatca      240

aggttcagtg gcagtgggtc tggggcagat tattctctca ccatcagcaa cctggaacct      300

gaagatattg ccacttacta ttgtcagcag tatagtaagc ttccgtggac gttcggtgga      360

ggcaccaagc tggaaatcaa acgggctgat gctgcaccaa ctgtatccat cttcccacca      420

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      480

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg      540

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      600

ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca      660

tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gttag                      705


<210>  24
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region of the B11 human monoclonal antibody

<400>  24
gatatccaga tgatacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gtgcaagtca ggacattagc aattatttaa actggtatca gcaaaaacca      120

gatggaactg ttaaactcct gatctattac acatccagtt tacgctcagg agtcccatca      180

aggttcagtg gcagtgggtc tggggcagat tattctctca ccatcagcaa cctggaacct      240

gaagatattg ccacttacta ttgtcagcag tatagtaagc ttccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  25
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H1A: Heavy chain DNA sequence

<400>  25
atgggatgga gctgtatcat cctcttcttg gtatcaacag ctacaggtgt ccactcccag       60

gtgcaactgc agcagtctgg gcctcagctg gttaggcctg ggacttcagt gaagatatcc      120

tgcaaggctt ctggttactc attcaccgat aactggatgc actgggtgaa gcagaggcct      180

ggacaaggtc ttgagtggat tggcatgatt gatccttccg atagtgaaac taggttaagt      240

cagaagttca aggacaaggc cacattgact gtagacaaat cctccaccac agcctacatg      300

caattcagca gcccgacatc tgaggactct gcggtctatt tctgtgcaag atcggataag      360

ttcgacggtt actatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      420

gccaaaacaa cagccccatc ggtctatcca ctggcccctg tgtgtggaga tacaactggc      480

tcctcggtga ctctaggatg cctggtcaag ggttatttcc ctgagccagt gaccttgacc      540

tggaactctg gatccctgtc cagtggtgtg cacaccttcc cagctgtcct gcagtctgac      600

ctctacaccc tcagcagctc agtgactgta acctcgagca cctggcccag ccagtccatc      660

acctgcaatg tggcccaccc ggcaagcagc accaaggtgg acaagaaaat tgagcccaga      720

gggcccacaa tcaagccctg tcctccatgc aaatgcccag cacctaacct cttgggtgga      780

ccatccgtct tcatcttccc tccaaagatc aaggatgtac tcatgatctc cctgagcccc      840

atagtcacat gtgtggtggt ggatgtgagc gaggatgacc cagatgtcca gatcagctgg      900

tttgtgaaca acgtggaagt acacacagct cagacacaaa cccatagaga ggattacaac      960

agtactctcc gggtggtcag tgccctcccc atccagcacc aggactggat gagtggcaag     1020

gagttcaaat gcaaggtcaa caacaaagac ctcccagcgc ccatcgagag aaccatctca     1080

aaacccaaag ggtcagtaag agctccacag gtatatgtct tgcctccacc agaagaagag     1140

atgactaaga aacaggtcac tctgacctgc atggtcacag acttcatgcc tgaagacatt     1200

tacgtggagt ggaccaacaa cgggaaaaca gagctaaact acaagaacac tgaaccagtc     1260

ctggactctg atggttctta cttcatgtac agcaagctga gagtggaaaa gaagaactgg     1320

gtggaaagaa atagctactc ctgttcagtg gtccacgagg gtctgcacaa tcaccacacg     1380

actaagagct tctcccggac tccgggtaaa tga                                  1413


<210>  26
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region of the H1A monoclonal antibody

<400>  26
caggtgcaac tgcagcagtc tgggcctcag ctggttaggc ctgggacttc agtgaagata       60

tcctgcaagg cttctggtta ctcattcacc gataactgga tgcactgggt gaagcagagg      120

cctggacaag gtcttgagtg gattggcatg attgatcctt ccgatagtga aactaggtta      180

agtcagaagt tcaaggacaa ggccacattg actgtagaca aatcctccac cacagcctac      240

atgcaattca gcagcccgac atctgaggac tctgcggtct atttctgtgc aagatcggat      300

aagttcgacg gttactatgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tca                                                                    363


<210>  27
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H1A: Light chain DNA sequence

<400>  27
atgagaccgt ctattcagtt cctggggctc ttgttgttct ggcttcatgg tgctcagtgt       60

gacatccaga tgacacagtc tccatcctca ctgtctgcat ctctgggagg cagagtcacc      120

atcacttgca aggcaagcca agacattgac aagtatatag cttggtacca acacaagcct      180

ggaaaaggtc ctaggctgct catacatcac acatctacat tacagccagg catcccatca      240

aggttcagtg gaagtgggtc tgggagagat ttttccttca gtatcagcaa cctggagcct      300

gaagatattg caacttatta ttgtctacag tatgattatc ttcggacgtt cggtggaggc      360

accaagctgg aaatcaaacg ggctgatgct gcaccaactg tatccatctt cccaccatcc      420

agtgagcagt taacatctgg aggtgcctca gtcgtgtgct tcttgaacaa cttctacccc      480

aaagacatca atgtcaagtg gaagattgat ggcagtgaac gacaaaatgg cgtcctgaac      540

agttggactg atcaggacag caaagacagc acctacagca tgagcagcac cctcacgttg      600

accaaggacg agtatgaacg acataacagc tatacctgtg aggccactca caagacatca      660

acttcaccca ttgtcaagag cttcaacagg aatgagtgtt ag                         702


<210>  28
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region of the H1A monoclonal antibody

<400>  28
gacatccaga tgacacagtc tccatcctca ctgtctgcat ctctgggagg cagagtcacc       60

atcacttgca aggcaagcca agacattgac aagtatatag cttggtacca acacaagcct      120

ggaaaaggtc ctaggctgct catacatcac acatctacat tacagccagg catcccatca      180

aggttcagtg gaagtgggtc tgggagagat ttttccttca gtatcagcaa cctggagcct      240

gaagatattg caacttatta ttgtctacag tatgattatc ttcggacgtt cggtggaggc      300

accaagctgg aaatcaaa                                                    318


<210>  29
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  canonical full-length B7-H1

<400>  29

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Leu Leu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  30
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  splice-variant sB7-H1

<400>  30

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Asp 
        


<210>  31
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  canonical B7-H1

<400>  31
ctgagtggta agaggagatt a                                                 21


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  canonical B7-H1

<400>  32

Leu Ser Gly Lys Arg Arg Leu 
1               5           


<210>  33
<211>  15
<212>  DNA
<213>  Artificial Sequnce

<220>
<223>  sB7-H1 splice variant

<400>  33
ctgagtggag attag                                                        15


<210>  34
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sB7-H1 splice variant

<400>  34

Leu Ser Gly Asp 
1               


