                         SEQUENCE LISTING

<110>  Loxo Oncology, Inc. & The Regents of the University of 
       Colorado, A Body Corporate
 
<120>  POINT MUTATIONS IN TRK INHIBITOR-RESISTANT CANCER AND METHODS 
       RELATING TO THE SAME

<130>  40449-0069WO1

<150>  62/246,580
<151>  2015-10-26

<150>  62/287,778
<151>  2016-01-27

<150>  62/323,586
<151>  2016-04-15

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  796
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Arg Gly Gly Arg Arg Gly Gln Leu Gly Trp His Ser Trp Ala 
1               5                   10                  15      


Ala Gly Pro Gly Ser Leu Leu Ala Trp Leu Ile Leu Ala Ser Ala Gly 
            20                  25                  30          


Ala Ala Pro Cys Pro Asp Ala Cys Cys Pro His Gly Ser Ser Gly Leu 
        35                  40                  45              


Arg Cys Thr Arg Asp Gly Ala Leu Asp Ser Leu His His Leu Pro Gly 
    50                  55                  60                  


Ala Glu Asn Leu Thr Glu Leu Tyr Ile Glu Asn Gln Gln His Leu Gln 
65                  70                  75                  80  


His Leu Glu Leu Arg Asp Leu Arg Gly Leu Gly Glu Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Lys Ser Gly Leu Arg Phe Val Ala Pro Asp Ala Phe His 
            100                 105                 110         


Phe Thr Pro Arg Leu Ser Arg Leu Asn Leu Ser Phe Asn Ala Leu Glu 
        115                 120                 125             


Ser Leu Ser Trp Lys Thr Val Gln Gly Leu Ser Leu Gln Glu Leu Val 
    130                 135                 140                 


Leu Ser Gly Asn Pro Leu His Cys Ser Cys Ala Leu Arg Trp Leu Gln 
145                 150                 155                 160 


Arg Trp Glu Glu Glu Gly Leu Gly Gly Val Pro Glu Gln Lys Leu Gln 
                165                 170                 175     


Cys His Gly Gln Gly Pro Leu Ala His Met Pro Asn Ala Ser Cys Gly 
            180                 185                 190         


Val Pro Thr Leu Lys Val Gln Val Pro Asn Ala Ser Val Asp Val Gly 
        195                 200                 205             


Asp Asp Val Leu Leu Arg Cys Gln Val Glu Gly Arg Gly Leu Glu Gln 
    210                 215                 220                 


Ala Gly Trp Ile Leu Thr Glu Leu Glu Gln Ser Ala Thr Val Met Lys 
225                 230                 235                 240 


Ser Gly Gly Leu Pro Ser Leu Gly Leu Thr Leu Ala Asn Val Thr Ser 
                245                 250                 255     


Asp Leu Asn Arg Lys Asn Val Thr Cys Trp Ala Glu Asn Asp Val Gly 
            260                 265                 270         


Arg Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala Ser Val 
        275                 280                 285             


Gln Leu His Thr Ala Val Glu Met His His Trp Cys Ile Pro Phe Ser 
    290                 295                 300                 


Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser 
305                 310                 315                 320 


Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Ala 
                325                 330                 335     


Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr 
            340                 345                 350         


His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Phe Gly 
        355                 360                 365             


Gln Ala Ser Ala Ser Ile Met Ala Ala Phe Met Asp Asn Pro Phe Glu 
    370                 375                 380                 


Phe Asn Pro Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr 
385                 390                 395                 400 


Asn Ser Thr Ser Gly Asp Pro Val Glu Lys Lys Asp Glu Thr Pro Phe 
                405                 410                 415     


Gly Val Ser Val Ala Val Gly Leu Ala Val Phe Ala Cys Leu Phe Leu 
            420                 425                 430         


Ser Thr Leu Leu Leu Val Leu Asn Lys Cys Gly Arg Arg Asn Lys Phe 
        435                 440                 445             


Gly Ile Asn Arg Pro Ala Val Leu Ala Pro Glu Asp Gly Leu Ala Met 
    450                 455                 460                 


Ser Leu His Phe Met Thr Leu Gly Gly Ser Ser Leu Ser Pro Thr Glu 
465                 470                 475                 480 


Gly Lys Gly Ser Gly Leu Gln Gly His Ile Ile Glu Asn Pro Gln Tyr 
                485                 490                 495     


Phe Ser Asp Ala Cys Val His His Ile Lys Arg Arg Asp Ile Val Leu 
            500                 505                 510         


Lys Trp Glu Leu Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu 
        515                 520                 525             


Cys His Asn Leu Leu Pro Glu Gln Asp Lys Met Leu Val Ala Val Lys 
    530                 535                 540                 


Ala Leu Lys Glu Ala Ser Glu Ser Ala Arg Gln Asp Phe Gln Arg Glu 
545                 550                 555                 560 


Ala Glu Leu Leu Thr Met Leu Gln His Gln His Ile Val Arg Phe Phe 
                565                 570                 575     


Gly Val Cys Thr Glu Gly Arg Pro Leu Leu Met Val Phe Glu Tyr Met 
            580                 585                 590         


Arg His Gly Asp Leu Asn Arg Phe Leu Arg Ser His Gly Pro Asp Ala 
        595                 600                 605             


Lys Leu Leu Ala Gly Gly Glu Asp Val Ala Pro Gly Pro Leu Gly Leu 
    610                 615                 620                 


Gly Gln Leu Leu Ala Val Ala Ser Gln Val Ala Ala Gly Met Val Tyr 
625                 630                 635                 640 


Leu Ala Gly Leu His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys 
                645                 650                 655     


Leu Val Gly Gln Gly Leu Val Val Lys Ile Gly Asp Phe Gly Met Ser 
            660                 665                 670         


Arg Asp Ile Tyr Ser Thr Asp Tyr Tyr Arg Val Gly Gly Arg Thr Met 
        675                 680                 685             


Leu Pro Ile Arg Trp Met Pro Pro Glu Ser Ile Leu Tyr Arg Lys Phe 
    690                 695                 700                 


Thr Thr Glu Ser Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Ile 
705                 710                 715                 720 


Phe Thr Tyr Gly Lys Gln Pro Trp Tyr Gln Leu Ser Asn Thr Glu Ala 
                725                 730                 735     


Ile Asp Cys Ile Thr Gln Gly Arg Glu Leu Glu Arg Pro Arg Ala Cys 
            740                 745                 750         


Pro Pro Glu Val Tyr Ala Ile Met Arg Gly Cys Trp Gln Arg Glu Pro 
        755                 760                 765             


Gln Gln Arg His Ser Ile Lys Asp Val His Ala Arg Leu Gln Ala Leu 
    770                 775                 780                 


Ala Gln Ala Pro Pro Val Tyr Leu Asp Val Leu Gly 
785                 790                 795     


<210>  2
<211>  2663
<212>  DNA
<213>  Homo sapiens

<400>  2
tgcagctggg agcgcacaga cggctgcccc gcctgagcga ggcgggcgcc gccgcgatgc       60

tgcgaggcgg acggcgcggg cagcttggct ggcacagctg ggctgcgggg ccgggcagcc      120

tgctggcttg gctgatactg gcatctgcgg gcgccgcacc ctgccccgat gcctgctgcc      180

cccacggctc ctcgggactg cgatgcaccc gggatggggc cctggatagc ctccaccacc      240

tgcccggcgc agagaacctg actgagctct acatcgagaa ccagcagcat ctgcagcatc      300

tggagctccg tgatctgagg ggcctggggg agctgagaaa cctcaccatc gtgaagagtg      360

gtctccgttt cgtggcgcca gatgccttcc atttcactcc tcggctcagt cgcctgaatc      420

tctccttcaa cgctctggag tctctctcct ggaaaactgt gcagggcctc tccttacagg      480

aactggtcct gtcggggaac cctctgcact gttcttgtgc cctgcgctgg ctacagcgct      540

gggaggagga gggactgggc ggagtgcctg aacagaagct gcagtgtcat gggcaagggc      600

ccctggccca catgcccaat gccagctgtg gtgtgcccac gctgaaggtc caggtgccca      660

atgcctcggt ggatgtgggg gacgacgtgc tgctgcggtg ccaggtggag gggcggggcc      720

tggagcaggc cggctggatc ctcacagagc tggagcagtc agccacggtg atgaaatctg      780

ggggtctgcc atccctgggg ctgaccctgg ccaatgtcac cagtgacctc aacaggaaga      840

acgtgacgtg ctgggcagag aacgatgtgg gccgggcaga ggtctctgtt caggtcaacg      900

tctccttccc ggccagtgtg cagctgcaca cggcggtgga gatgcaccac tggtgcatcc      960

ccttctctgt ggatgggcag ccggcaccgt ctctgcgctg gctcttcaat ggctccgtgc     1020

tcaatgagac cagcttcatc ttcactgagt tcctggagcc ggcagccaat gagaccgtgc     1080

ggcacgggtg tctgcgcctc aaccagccca cccacgtcaa caacggcaac tacacgctgc     1140

tggctgccaa ccccttcggc caggcctccg cctccatcat ggctgccttc atggacaacc     1200

ctttcgagtt caaccccgag gaccccatcc ctgtctcctt ctcgccggtg gacactaaca     1260

gcacatctgg agacccggtg gagaagaagg acgaaacacc ttttggggtc tcggtggctg     1320

tgggcctggc cgtctttgcc tgcctcttcc tttctacgct gctccttgtg ctcaacaaat     1380

gtggacggag aaacaagttt gggatcaacc gcccggctgt gctggctcca gaggatgggc     1440

tggccatgtc cctgcatttc atgacattgg gtggcagctc cctgtccccc accgagggca     1500

aaggctctgg gctccaaggc cacatcatcg agaacccaca atacttcagt gatgcctgtg     1560

ttcaccacat caagcgccgg gacatcgtgc tcaagtggga gctgggggag ggcgcctttg     1620

ggaaggtctt ccttgctgag tgccacaacc tcctgcctga gcaggacaag atgctggtgg     1680

ctgtcaaggc actgaaggag gcgtccgaga gtgctcggca ggacttccag cgtgaggctg     1740

agctgctcac catgctgcag caccagcaca tcgtgcgctt cttcggcgtc tgcaccgagg     1800

gccgccccct gctcatggtc tttgagtata tgcggcacgg ggacctcaac cgcttcctcc     1860

gatcccatgg acctgatgcc aagctgctgg ctggtgggga ggatgtggct ccaggccccc     1920

tgggtctggg gcagctgctg gccgtggcta gccaggtcgc tgcggggatg gtgtacctgg     1980

cgggtctgca ttttgtgcac cgggacctgg ccacacgcaa ctgtctagtg ggccagggac     2040

tggtggtcaa gattggtgat tttggcatga gcagggatat ctacagcacc gactattacc     2100

gtgtgggagg ccgcaccatg ctgcccattc gctggatgcc gcccgagagc atcctgtacc     2160

gtaagttcac caccgagagc gacgtgtgga gcttcggcgt ggtgctctgg gagatcttca     2220

cctacggcaa gcagccctgg taccagctct ccaacacgga ggcaatcgac tgcatcacgc     2280

agggacgtga gttggagcgg ccacgtgcct gcccaccaga ggtctacgcc atcatgcggg     2340

gctgctggca gcgggagccc cagcaacgcc acagcatcaa ggatgtgcac gcccggctgc     2400

aagccctggc ccaggcacct cctgtctacc tggatgtcct gggctagggg gccggcccag     2460

gggctgggag tggttagccg gaatactggg gcctgccctc agcatccccc atagctccca     2520

gcagccccag ggtgatctca aagtatctaa ttcaccctca gcatgtggga agggacaggt     2580

gggggctggg agtagaggat gttcctgctt ctctaggcaa ggtcccgtca tagcaattat     2640

atttattatc ccttgaaaaa aaa                                             2663


<210>  3
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Lys Glu Ala Ala Leu Ile Cys Leu Ala Pro Ser Val Pro Pro Ile 
1               5                   10                  15      


Leu Thr Val Lys Ser Trp Asp Thr Met Gln Leu Arg Ala Ala Arg Ser 
            20                  25                  30          


Arg Cys Thr Asn Leu Leu Ala Ala Ser Tyr Ile Glu Asn Gln Gln His 
        35                  40                  45              


Leu Gln His Leu Glu Leu Arg Asp Leu Arg Gly Leu Gly Glu Leu Arg 
    50                  55                  60                  


Asn Leu Thr Ile Val Lys Ser Gly Leu Arg Phe Val Ala Pro Asp Ala 
65                  70                  75                  80  


Phe His Phe Thr Pro Arg Leu Ser Arg Leu Asn Leu Ser Phe Asn Ala 
                85                  90                  95      


Leu Glu Ser Leu Ser Trp Lys Thr Val Gln Gly Leu Ser Leu Gln Glu 
            100                 105                 110         


Leu Val Leu Ser Gly Asn Pro Leu His Cys Ser Cys Ala Leu Arg Trp 
        115                 120                 125             


Leu Gln Arg Trp Glu Glu Glu Gly Leu Gly Gly Val Pro Glu Gln Lys 
    130                 135                 140                 


Leu Gln Cys His Gly Gln Gly Pro Leu Ala His Met Pro Asn Ala Ser 
145                 150                 155                 160 


Cys Gly Val Pro Thr Leu Lys Val Gln Val Pro Asn Ala Ser Val Asp 
                165                 170                 175     


Val Gly Asp Asp Val Leu Leu Arg Cys Gln Val Glu Gly Arg Gly Leu 
            180                 185                 190         


Glu Gln Ala Gly Trp Ile Leu Thr Glu Leu Glu Gln Ser Ala Thr Val 
        195                 200                 205             


Met Lys Ser Gly Gly Leu Pro Ser Leu Gly Leu Thr Leu Ala Asn Val 
    210                 215                 220                 


Thr Ser Asp Leu Asn Arg Lys Asn Val Thr Cys Trp Ala Glu Asn Asp 
225                 230                 235                 240 


Val Gly Arg Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala 
                245                 250                 255     


Ser Val Gln Leu His Thr Ala Val Glu Met His His Trp Cys Ile Pro 
            260                 265                 270         


Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn 
        275                 280                 285             


Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu 
    290                 295                 300                 


Pro Ala Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln 
305                 310                 315                 320 


Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro 
                325                 330                 335     


Phe Gly Gln Ala Ser Ala Ser Ile Met Ala Ala Phe Met Asp Asn Pro 
            340                 345                 350         


Phe Glu Phe Asn Pro Glu Asp Pro Ile Pro Asp Thr Asn Ser Thr Ser 
        355                 360                 365             


Gly Asp Pro Val Glu Lys Lys Asp Glu Thr Pro Phe Gly Val Ser Val 
    370                 375                 380                 


Ala Val Gly Leu Ala Val Phe Ala Cys Leu Phe Leu Ser Thr Leu Leu 
385                 390                 395                 400 


Leu Val Leu Asn Lys Cys Gly Arg Arg Asn Lys Phe Gly Ile Asn Arg 
                405                 410                 415     


Pro Ala Val Leu Ala Pro Glu Asp Gly Leu Ala Met Ser Leu His Phe 
            420                 425                 430         


Met Thr Leu Gly Gly Ser Ser Leu Ser Pro Thr Glu Gly Lys Gly Ser 
        435                 440                 445             


Gly Leu Gln Gly His Ile Ile Glu Asn Pro Gln Tyr Phe Ser Asp Ala 
    450                 455                 460                 


Cys Val His His Ile Lys Arg Arg Asp Ile Val Leu Lys Trp Glu Leu 
465                 470                 475                 480 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys His Asn Leu 
                485                 490                 495     


Leu Pro Glu Gln Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Glu 
            500                 505                 510         


Ala Ser Glu Ser Ala Arg Gln Asp Phe Gln Arg Glu Ala Glu Leu Leu 
        515                 520                 525             


Thr Met Leu Gln His Gln His Ile Val Arg Phe Phe Gly Val Cys Thr 
    530                 535                 540                 


Glu Gly Arg Pro Leu Leu Met Val Phe Glu Tyr Met Arg His Gly Asp 
545                 550                 555                 560 


Leu Asn Arg Phe Leu Arg Ser His Gly Pro Asp Ala Lys Leu Leu Ala 
                565                 570                 575     


Gly Gly Glu Asp Val Ala Pro Gly Pro Leu Gly Leu Gly Gln Leu Leu 
            580                 585                 590         


Ala Val Ala Ser Gln Val Ala Ala Gly Met Val Tyr Leu Ala Gly Leu 
        595                 600                 605             


His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Gln 
    610                 615                 620                 


Gly Leu Val Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Ile Tyr 
625                 630                 635                 640 


Ser Thr Asp Tyr Tyr Arg Val Gly Gly Arg Thr Met Leu Pro Ile Arg 
                645                 650                 655     


Trp Met Pro Pro Glu Ser Ile Leu Tyr Arg Lys Phe Thr Thr Glu Ser 
            660                 665                 670         


Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly 
        675                 680                 685             


Lys Gln Pro Trp Tyr Gln Leu Ser Asn Thr Glu Ala Ile Asp Cys Ile 
    690                 695                 700                 


Thr Gln Gly Arg Glu Leu Glu Arg Pro Arg Ala Cys Pro Pro Glu Val 
705                 710                 715                 720 


Tyr Ala Ile Met Arg Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg His 
                725                 730                 735     


Ser Ile Lys Asp Val His Ala Arg Leu Gln Ala Leu Ala Gln Ala Pro 
            740                 745                 750         


Pro Val Tyr Leu Asp Val Leu Gly 
        755                 760 


<210>  4
<211>  2581
<212>  DNA
<213>  Homo sapiens

<400>  4
gcaccctggt catctgcgga ctcagcctga gcttccagag ggcctaggag cagtaaggga       60

gtgagtgggc aactcggcgc atgaaggagg ccgccctcat ctgcctggca ccctctgtac      120

ccccgatctt gacggtgaag tcctgggaca ccatgcagtt gcgggctgct agatctcggt      180

gcacaaactt gttggcagca agctacatcg agaaccagca gcatctgcag catctggagc      240

tccgtgatct gaggggcctg ggggagctga gaaacctcac catcgtgaag agtggtctcc      300

gtttcgtggc gccagatgcc ttccatttca ctcctcggct cagtcgcctg aatctctcct      360

tcaacgctct ggagtctctc tcctggaaaa ctgtgcaggg cctctcctta caggaactgg      420

tcctgtcggg gaaccctctg cactgttctt gtgccctgcg ctggctacag cgctgggagg      480

aggagggact gggcggagtg cctgaacaga agctgcagtg tcatgggcaa gggcccctgg      540

cccacatgcc caatgccagc tgtggtgtgc ccacgctgaa ggtccaggtg cccaatgcct      600

cggtggatgt gggggacgac gtgctgctgc ggtgccaggt ggaggggcgg ggcctggagc      660

aggccggctg gatcctcaca gagctggagc agtcagccac ggtgatgaaa tctgggggtc      720

tgccatccct ggggctgacc ctggccaatg tcaccagtga cctcaacagg aagaacgtga      780

cgtgctgggc agagaacgat gtgggccggg cagaggtctc tgttcaggtc aacgtctcct      840

tcccggccag tgtgcagctg cacacggcgg tggagatgca ccactggtgc atccccttct      900

ctgtggatgg gcagccggca ccgtctctgc gctggctctt caatggctcc gtgctcaatg      960

agaccagctt catcttcact gagttcctgg agccggcagc caatgagacc gtgcggcacg     1020

ggtgtctgcg cctcaaccag cccacccacg tcaacaacgg caactacacg ctgctggctg     1080

ccaacccctt cggccaggcc tccgcctcca tcatggctgc cttcatggac aaccctttcg     1140

agttcaaccc cgaggacccc atccctgaca ctaacagcac atctggagac ccggtggaga     1200

agaaggacga aacacctttt ggggtctcgg tggctgtggg cctggccgtc tttgcctgcc     1260

tcttcctttc tacgctgctc cttgtgctca acaaatgtgg acggagaaac aagtttggga     1320

tcaaccgccc ggctgtgctg gctccagagg atgggctggc catgtccctg catttcatga     1380

cattgggtgg cagctccctg tcccccaccg agggcaaagg ctctgggctc caaggccaca     1440

tcatcgagaa cccacaatac ttcagtgatg cctgtgttca ccacatcaag cgccgggaca     1500

tcgtgctcaa gtgggagctg ggggagggcg cctttgggaa ggtcttcctt gctgagtgcc     1560

acaacctcct gcctgagcag gacaagatgc tggtggctgt caaggcactg aaggaggcgt     1620

ccgagagtgc tcggcaggac ttccagcgtg aggctgagct gctcaccatg ctgcagcacc     1680

agcacatcgt gcgcttcttc ggcgtctgca ccgagggccg ccccctgctc atggtctttg     1740

agtatatgcg gcacggggac ctcaaccgct tcctccgatc ccatggacct gatgccaagc     1800

tgctggctgg tggggaggat gtggctccag gccccctggg tctggggcag ctgctggccg     1860

tggctagcca ggtcgctgcg gggatggtgt acctggcggg tctgcatttt gtgcaccggg     1920

acctggccac acgcaactgt ctagtgggcc agggactggt ggtcaagatt ggtgattttg     1980

gcatgagcag ggatatctac agcaccgact attaccgtgt gggaggccgc accatgctgc     2040

ccattcgctg gatgccgccc gagagcatcc tgtaccgtaa gttcaccacc gagagcgacg     2100

tgtggagctt cggcgtggtg ctctgggaga tcttcaccta cggcaagcag ccctggtacc     2160

agctctccaa cacggaggca atcgactgca tcacgcaggg acgtgagttg gagcggccac     2220

gtgcctgccc accagaggtc tacgccatca tgcggggctg ctggcagcgg gagccccagc     2280

aacgccacag catcaaggat gtgcacgccc ggctgcaagc cctggcccag gcacctcctg     2340

tctacctgga tgtcctgggc tagggggccg gcccaggggc tgggagtggt tagccggaat     2400

actggggcct gccctcagca tcccccatag ctcccagcag ccccagggtg atctcaaagt     2460

atctaattca ccctcagcat gtgggaaggg acaggtgggg gctgggagta gaggatgttc     2520

ctgcttctct aggcaaggtc ccgtcatagc aattatattt attatccctt gaaaaaaaaa     2580

a                                                                     2581


<210>  5
<211>  822
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Ser Trp Ile Arg Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Phe Cys Trp Leu Val Val Gly Phe Trp Arg Ala Ala Phe Ala Cys 
            20                  25                  30          


Pro Thr Ser Cys Lys Cys Ser Ala Ser Arg Ile Trp Cys Ser Asp Pro 
        35                  40                  45              


Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Val Asp 
    50                  55                  60                  


Pro Glu Asn Ile Thr Glu Ile Phe Ile Ala Asn Gln Lys Arg Leu Glu 
65                  70                  75                  80  


Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala His Lys Ala Phe Leu 
            100                 105                 110         


Lys Asn Ser Asn Leu Gln His Ile Asn Phe Thr Arg Asn Lys Leu Thr 
        115                 120                 125             


Ser Leu Ser Arg Lys His Phe Arg His Leu Asp Leu Ser Glu Leu Ile 
    130                 135                 140                 


Leu Val Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Ile Lys 
145                 150                 155                 160 


Thr Leu Gln Glu Ala Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr Cys 
                165                 170                 175     


Leu Asn Glu Ser Ser Lys Asn Ile Pro Leu Ala Asn Leu Gln Ile Pro 
            180                 185                 190         


Asn Cys Gly Leu Pro Ser Ala Asn Leu Ala Ala Pro Asn Leu Thr Val 
        195                 200                 205             


Glu Glu Gly Lys Ser Ile Thr Leu Ser Cys Ser Val Ala Gly Asp Pro 
    210                 215                 220                 


Val Pro Asn Met Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met 
225                 230                 235                 240 


Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile Ser 
                245                 250                 255     


Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val 
            260                 265                 270         


Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro Thr 
        275                 280                 285             


Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile Pro 
    290                 295                 300                 


Phe Thr Val Lys Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr Asn 
305                 310                 315                 320 


Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His Val 
                325                 330                 335     


Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro Thr 
            340                 345                 350         


His Met Asn Asn Gly Asp Tyr Thr Leu Ile Ala Lys Asn Glu Tyr Gly 
        355                 360                 365             


Lys Asp Glu Lys Gln Ile Ser Ala His Phe Met Gly Trp Pro Gly Ile 
    370                 375                 380                 


Asp Asp Gly Ala Asn Pro Asn Tyr Pro Asp Val Ile Tyr Glu Asp Tyr 
385                 390                 395                 400 


Gly Thr Ala Ala Asn Asp Ile Gly Asp Thr Thr Asn Arg Ser Asn Glu 
                405                 410                 415     


Ile Pro Ser Thr Asp Val Thr Asp Lys Thr Gly Arg Glu His Leu Ser 
            420                 425                 430         


Val Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys Leu Leu 
        435                 440                 445             


Val Met Leu Phe Leu Leu Lys Leu Ala Arg His Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Pro Ala Ser Val Ile Ser Asn Asp Asp Asp Ser Ala Ser Pro 
465                 470                 475                 480 


Leu His His Ile Ser Asn Gly Ser Asn Thr Pro Ser Ser Ser Glu Gly 
                485                 490                 495     


Gly Pro Asp Ala Val Ile Ile Gly Met Thr Lys Ile Pro Val Ile Glu 
            500                 505                 510         


Asn Pro Gln Tyr Phe Gly Ile Thr Asn Ser Gln Leu Lys Pro Asp Thr 
        515                 520                 525             


Phe Val Gln His Ile Lys Arg His Asn Ile Val Leu Lys Arg Glu Leu 
    530                 535                 540                 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu 
545                 550                 555                 560 


Cys Pro Glu Gln Asp Lys Ile Leu Val Ala Val Lys Thr Leu Lys Asp 
                565                 570                 575     


Ala Ser Asp Asn Ala Arg Lys Asp Phe His Arg Glu Ala Glu Leu Leu 
            580                 585                 590         


Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Val 
        595                 600                 605             


Glu Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp 
    610                 615                 620                 


Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Val Leu Met Ala 
625                 630                 635                 640 


Glu Gly Asn Pro Pro Thr Glu Leu Thr Gln Ser Gln Met Leu His Ile 
                645                 650                 655     


Ala Gln Gln Ile Ala Ala Gly Met Val Tyr Leu Ala Ser Gln His Phe 
            660                 665                 670         


Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Glu Asn Leu 
        675                 680                 685             


Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val Tyr Ser Thr 
    690                 695                 700                 


Asp Tyr Tyr Arg Val Gly Gly His Thr Met Leu Pro Ile Arg Trp Met 
705                 710                 715                 720 


Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val 
                725                 730                 735     


Trp Ser Leu Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln 
            740                 745                 750         


Pro Trp Tyr Gln Leu Ser Asn Asn Glu Val Ile Glu Cys Ile Thr Gln 
        755                 760                 765             


Gly Arg Val Leu Gln Arg Pro Arg Thr Cys Pro Gln Glu Val Tyr Glu 
    770                 775                 780                 


Leu Met Leu Gly Cys Trp Gln Arg Glu Pro His Met Arg Lys Asn Ile 
785                 790                 795                 800 


Lys Gly Ile His Thr Leu Leu Gln Asn Leu Ala Lys Ala Ser Pro Val 
                805                 810                 815     


Tyr Leu Asp Ile Leu Gly 
            820         


<210>  6
<211>  3194
<212>  DNA
<213>  Homo sapiens

<400>  6
ggaaggttta aagaagaagc cgcaaagcgc agggaaggcc tcccggcacg ggtgggggaa       60

agcggccggt gcagcgcggg gacaggcact cgggctggca ctggctgcta gggatgtcgt      120

cctggataag gtggcatgga cccgccatgg cgcggctctg gggcttctgc tggctggttg      180

tgggcttctg gagggccgct ttcgcctgtc ccacgtcctg caaatgcagt gcctctcgga      240

tctggtgcag cgacccttct cctggcatcg tggcatttcc gagattggag cctaacagtg      300

tagatcctga gaacatcacc gaaattttca tcgcaaacca gaaaaggtta gaaatcatca      360

acgaagatga tgttgaagct tatgtgggac tgagaaatct gacaattgtg gattctggat      420

taaaatttgt ggctcataaa gcatttctga aaaacagcaa cctgcagcac atcaatttta      480

cccgaaacaa actgacgagt ttgtctagga aacatttccg tcaccttgac ttgtctgaac      540

tgatcctggt gggcaatcca tttacatgct cctgtgacat tatgtggatc aagactctcc      600

aagaggctaa atccagtcca gacactcagg atttgtactg cctgaatgaa agcagcaaga      660

atattcccct ggcaaacctg cagataccca attgtggttt gccatctgca aatctggccg      720

cacctaacct cactgtggag gaaggaaagt ctatcacatt atcctgtagt gtggcaggtg      780

atccggttcc taatatgtat tgggatgttg gtaacctggt ttccaaacat atgaatgaaa      840

caagccacac acagggctcc ttaaggataa ctaacatttc atccgatgac agtgggaagc      900

agatctcttg tgtggcggaa aatcttgtag gagaagatca agattctgtc aacctcactg      960

tgcattttgc accaactatc acatttctcg aatctccaac ctcagaccac cactggtgca     1020

ttccattcac tgtgaaaggc aacccaaaac cagcgcttca gtggttctat aacggggcaa     1080

tattgaatga gtccaaatac atctgtacta aaatacatgt taccaatcac acggagtacc     1140

acggctgcct ccagctggat aatcccactc acatgaacaa tggggactac actctaatag     1200

ccaagaatga gtatgggaag gatgagaaac agatttctgc tcacttcatg ggctggcctg     1260

gaattgacga tggtgcaaac ccaaattatc ctgatgtaat ttatgaagat tatggaactg     1320

cagcgaatga catcggggac accacgaaca gaagtaatga aatcccttcc acagacgtca     1380

ctgataaaac cggtcgggaa catctctcgg tctatgctgt ggtggtgatt gcgtctgtgg     1440

tgggattttg ccttttggta atgctgtttc tgcttaagtt ggcaagacac tccaagtttg     1500

gcatgaaagg cccagcctcc gttatcagca atgatgatga ctctgccagc ccactccatc     1560

acatctccaa tgggagtaac actccatctt cttcggaagg tggcccagat gctgtcatta     1620

ttggaatgac caagatccct gtcattgaaa atccccagta ctttggcatc accaacagtc     1680

agctcaagcc agacacattt gttcagcaca tcaagcgaca taacattgtt ctgaaaaggg     1740

agctaggcga aggagccttt ggaaaagtgt tcctagctga atgctataac ctctgtcctg     1800

agcaggacaa gatcttggtg gcagtgaaga ccctgaagga tgccagtgac aatgcacgca     1860

aggacttcca ccgtgaggcc gagctcctga ccaacctcca gcatgagcac atcgtcaagt     1920

tctatggcgt ctgcgtggag ggcgaccccc tcatcatggt ctttgagtac atgaagcatg     1980

gggacctcaa caagttcctc agggcacacg gccctgatgc cgtgctgatg gctgagggca     2040

acccgcccac ggaactgacg cagtcgcaga tgctgcatat agcccagcag atcgccgcgg     2100

gcatggtcta cctggcgtcc cagcacttcg tgcaccgcga tttggccacc aggaactgcc     2160

tggtcgggga gaacttgctg gtgaaaatcg gggactttgg gatgtcccgg gacgtgtaca     2220

gcactgacta ctacagggtc ggtggccaca caatgctgcc cattcgctgg atgcctccag     2280

agagcatcat gtacaggaaa ttcacgacgg aaagcgacgt ctggagcctg ggggtcgtgt     2340

tgtgggagat tttcacctat ggcaaacagc cctggtacca gctgtcaaac aatgaggtga     2400

tagagtgtat cactcagggc cgagtcctgc agcgaccccg cacgtgcccc caggaggtgt     2460

atgagctgat gctggggtgc tggcagcgag agccccacat gaggaagaac atcaagggca     2520

tccataccct ccttcagaac ttggccaagg catctccggt ctacctggac attctaggct     2580

agggcccttt tccccagacc gatccttccc aacgtactcc tcagacgggc tgagaggatg     2640

aacatctttt aactgccgct ggaggccacc aagctgctct ccttcactct gacagtatta     2700

acatcaaaga ctccgagaag ctctcgaggg aagcagtgtg tacttcttca tccatagaca     2760

cagtattgac ttctttttgg cattatctct ttctctcttt ccatctccct tggttgttcc     2820

tttttctttt tttaaatttt ctttttcttc ttttttttcg tcttccctgc ttcacgattc     2880

ttaccctttc ttttgaatca atctggcttc tgcattacta ttaactctgc atagacaaag     2940

gccttaacaa acgtaatttg ttatatcagc agacactcca gtttgcccac cacaactaac     3000

aatgccttgt tgtattcctg cctttgatgt ggatgaaaaa aagggaaaac aaatatttca     3060

cttaaacttt gtcacttctg ctgtacagat atcgagagtt tctatggatt cacttctatt     3120

tatttattat tattactgtt cttattgttt ttggatggct taagcctgtg tataaaaaaa     3180

aaaaaaaatc taga                                                       3194


<210>  7
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Asp Val Ser Leu Cys Pro Ala Lys Cys Ser Phe Trp Arg Ile Phe 
1               5                   10                  15      


Leu Leu Gly Ser Val Trp Leu Asp Tyr Val Gly Ser Val Leu Ala Cys 
            20                  25                  30          


Pro Ala Asn Cys Val Cys Ser Lys Thr Glu Ile Asn Cys Arg Arg Pro 
        35                  40                  45              


Asp Asp Gly Asn Leu Phe Pro Leu Leu Glu Gly Gln Asp Ser Gly Asn 
    50                  55                  60                  


Ser Asn Gly Asn Ala Asn Ile Asn Ile Thr Asp Ile Ser Arg Asn Ile 
65                  70                  75                  80  


Thr Ser Ile His Ile Glu Asn Trp Arg Ser Leu His Thr Leu Asn Ala 
                85                  90                  95      


Val Asp Met Glu Leu Tyr Thr Gly Leu Gln Lys Leu Thr Ile Lys Asn 
            100                 105                 110         


Ser Gly Leu Arg Ser Ile Gln Pro Arg Ala Phe Ala Lys Asn Pro His 
        115                 120                 125             


Leu Arg Tyr Ile Asn Leu Ser Ser Asn Arg Leu Thr Thr Leu Ser Trp 
    130                 135                 140                 


Gln Leu Phe Gln Thr Leu Ser Leu Arg Glu Leu Gln Leu Glu Gln Asn 
145                 150                 155                 160 


Phe Phe Asn Cys Ser Cys Asp Ile Arg Trp Met Gln Leu Trp Gln Glu 
                165                 170                 175     


Gln Gly Glu Ala Lys Leu Asn Ser Gln Asn Leu Tyr Cys Ile Asn Ala 
            180                 185                 190         


Asp Gly Ser Gln Leu Pro Leu Phe Arg Met Asn Ile Ser Gln Cys Asp 
        195                 200                 205             


Leu Pro Glu Ile Ser Val Ser His Val Asn Leu Thr Val Arg Glu Gly 
    210                 215                 220                 


Asp Asn Ala Val Ile Thr Cys Asn Gly Ser Gly Ser Pro Leu Pro Asp 
225                 230                 235                 240 


Val Asp Trp Ile Val Thr Gly Leu Gln Ser Ile Asn Thr His Gln Thr 
                245                 250                 255     


Asn Leu Asn Trp Thr Asn Val His Ala Ile Asn Leu Thr Leu Val Asn 
            260                 265                 270         


Val Thr Ser Glu Asp Asn Gly Phe Thr Leu Thr Cys Ile Ala Glu Asn 
        275                 280                 285             


Val Val Gly Met Ser Asn Ala Ser Val Ala Leu Thr Val Tyr Tyr Pro 
    290                 295                 300                 


Pro Arg Val Val Ser Leu Glu Glu Pro Glu Leu Arg Leu Glu His Cys 
305                 310                 315                 320 


Ile Glu Phe Val Val Arg Gly Asn Pro Pro Pro Thr Leu His Trp Leu 
                325                 330                 335     


His Asn Gly Gln Pro Leu Arg Glu Ser Lys Ile Ile His Val Glu Tyr 
            340                 345                 350         


Tyr Gln Glu Gly Glu Ile Ser Glu Gly Cys Leu Leu Phe Asn Lys Pro 
        355                 360                 365             


Thr His Tyr Asn Asn Gly Asn Tyr Thr Leu Ile Ala Lys Asn Pro Leu 
    370                 375                 380                 


Gly Thr Ala Asn Gln Thr Ile Asn Gly His Phe Leu Lys Glu Pro Phe 
385                 390                 395                 400 


Pro Glu Ser Thr Asp Asn Phe Ile Leu Phe Asp Glu Val Ser Pro Thr 
                405                 410                 415     


Pro Pro Ile Thr Val Thr His Lys Pro Glu Glu Asp Thr Phe Gly Val 
            420                 425                 430         


Ser Ile Ala Val Gly Leu Ala Ala Phe Ala Cys Val Leu Leu Val Val 
        435                 440                 445             


Leu Phe Val Met Ile Asn Lys Tyr Gly Arg Arg Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Pro Val Ala Val Ile Ser Gly Glu Glu Asp Ser Ala Ser Pro 
465                 470                 475                 480 


Leu His His Ile Asn His Gly Ile Thr Thr Pro Ser Ser Leu Asp Ala 
                485                 490                 495     


Gly Pro Asp Thr Val Val Ile Gly Met Thr Arg Ile Pro Val Ile Glu 
            500                 505                 510         


Asn Pro Gln Tyr Phe Arg Gln Gly His Asn Cys His Lys Pro Asp Thr 
        515                 520                 525             


Tyr Val Gln His Ile Lys Arg Arg Asp Ile Val Leu Lys Arg Glu Leu 
    530                 535                 540                 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu 
545                 550                 555                 560 


Ser Pro Thr Lys Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Asp 
                565                 570                 575     


Pro Thr Leu Ala Ala Arg Lys Asp Phe Gln Arg Glu Ala Glu Leu Leu 
            580                 585                 590         


Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Gly 
        595                 600                 605             


Asp Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp 
    610                 615                 620                 


Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Met Ile Leu Val 
625                 630                 635                 640 


Asp Gly Gln Pro Arg Gln Ala Lys Gly Glu Leu Gly Leu Ser Gln Met 
                645                 650                 655     


Leu His Ile Ala Ser Gln Ile Ala Ser Gly Met Val Tyr Leu Ala Ser 
            660                 665                 670         


Gln His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly 
        675                 680                 685             


Ala Asn Leu Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val 
    690                 695                 700                 


Tyr Ser Thr Asp Tyr Tyr Arg Leu Phe Asn Pro Ser Gly Asn Asp Phe 
705                 710                 715                 720 


Cys Ile Trp Cys Glu Val Gly Gly His Thr Met Leu Pro Ile Arg Trp 
                725                 730                 735     


Met Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp 
            740                 745                 750         


Val Trp Ser Phe Gly Val Ile Leu Trp Glu Ile Phe Thr Tyr Gly Lys 
        755                 760                 765             


Gln Pro Trp Phe Gln Leu Ser Asn Thr Glu Val Ile Glu Cys Ile Thr 
    770                 775                 780                 


Gln Gly Arg Val Leu Glu Arg Pro Arg Val Cys Pro Lys Glu Val Tyr 
785                 790                 795                 800 


Asp Val Met Leu Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg Leu Asn 
                805                 810                 815     


Ile Lys Glu Ile Tyr Lys Ile Leu His Ala Leu Gly Lys Ala Thr Pro 
            820                 825                 830         


Ile Tyr Leu Asp Ile Leu Gly 
        835                 


<210>  8
<211>  2715
<212>  DNA
<213>  Homo sapiens

<400>  8
ggatccgcgt cggagatgga tgtctctctt tgcccagcca agtgtagttt ctggcggatt       60

ttcttgctgg gaagcgtctg gctggactat gtgggctccg tgctggcttg ccctgcaaat      120

tgtgtctgca gcaagactga gatcaattgc cggcggccgg acgatgggaa cctcttcccc      180

ctcctggaag ggcaggattc agggaacagc aatgggaacg ccaatatcaa catcacggac      240

atctcaagga atatcacttc catacacata gagaactggc gcagtcttca cacgctcaac      300

gccgtggaca tggagctcta caccggactt caaaagctga ccatcaagaa ctcaggactt      360

cggagcattc agcccagagc ctttgccaag aacccccatt tgcgttatat aaacctgtca      420

agtaaccggc tcaccacact ctcgtggcag ctcttccaga cgctgagtct tcgggaattg      480

cagttggagc agaacttttt caactgcagc tgtgacatcc gctggatgca gctctggcag      540

gagcaggggg aggccaagct caacagccag aacctctact gcatcaatgc tgatggctcc      600

cagcttcctc tcttccgcat gaacatcagt cagtgtgacc ttcctgagat cagcgtgagc      660

cacgtcaacc tgaccgtacg agagggtgac aatgctgtta tcacttgcaa tggctctgga      720

tcaccccttc ctgatgtgga ctggatagtc actgggctgc agtccatcaa cactcaccag      780

accaatctga actggaccaa tgttcatgcc atcaacttga cgctggtgaa tgtgacgagt      840

gaggacaatg gcttcaccct gacgtgcatt gcagagaacg tggtgggcat gagcaatgcc      900

agtgttgccc tcactgtcta ctatccccca cgtgtggtga gcctggagga gcctgagctg      960

cgcctggagc actgcatcga gtttgtggtg cgtggcaacc ccccaccaac gctgcactgg     1020

ctgcacaatg ggcagcctct gcgggagtcc aagatcatcc atgtggaata ctaccaagag     1080

ggagagattt ccgagggctg cctgctcttc aacaagccca cccactacaa caatggcaac     1140

tataccctca ttgccaaaaa cccactgggc acagccaacc agaccatcaa tggccacttc     1200

ctcaaggagc cctttccaga gagcacggat aactttatct tgtttgacga agtgagtccc     1260

acacctccta tcactgtgac ccacaaacca gaagaagaca cttttggggt atccatagca     1320

gttggacttg ctgcttttgc ctgtgtcctg ttggtggttc tcttcgtcat gatcaacaaa     1380

tatggtcgac ggtccaaatt tggaatgaag ggtcccgtgg ctgtcatcag tggtgaggag     1440

gactcagcca gcccactgca ccacatcaac cacggcatca ccacgccctc gtcactggat     1500

gccgggcccg acactgtggt cattggcatg actcgcatcc ctgtcattga gaacccccag     1560

tacttccgtc agggacacaa ctgccacaag ccggacacgt atgtgcagca cattaagagg     1620

agagacatcg tgctgaagcg agaactgggt gagggagcct ttggaaaggt cttcctggcc     1680

gagtgctaca acctcagccc gaccaaggac aagatgcttg tggctgtgaa ggccctgaag     1740

gatcccaccc tggctgcccg gaaggatttc cagagggagg ccgagctgct caccaacctg     1800

cagcatgagc acattgtcaa gttctatgga gtgtgcggcg atggggaccc cctcatcatg     1860

gtctttgaat acatgaagca tggagacctg aataagttcc tcagggccca tgggccagat     1920

gcaatgatcc ttgtggatgg acagccacgc caggccaagg gtgagctggg gctctcccaa     1980

atgctccaca ttgccagtca gatcgcctcg ggtatggtgt acctggcctc ccagcacttt     2040

gtgcaccgag acctggccac caggaactgc ctggttggag cgaatctgct agtgaagatt     2100

ggggacttcg gcatgtccag agatgtctac agcacggatt attacaggct ctttaatcca     2160

tctggaaatg atttttgtat atggtgtgag gtgggaggac acaccatgct ccccattcgc     2220

tggatgcctc ctgaaagcat catgtaccgg aagttcacta cagagagtga tgtatggagc     2280

ttcggggtga tcctctggga gatcttcacc tatggaaagc agccatggtt ccaactctca     2340

aacacggagg tcattgagtg cattacccaa ggtcgtgttt tggagcggcc ccgagtctgc     2400

cccaaagagg tgtacgatgt catgctgggg tgctggcaga gggaaccaca gcagcggttg     2460

aacatcaagg agatctacaa aatcctccat gctttgggga aggccacccc aatctacctg     2520

gacattcttg gctagtggtg gctggtggtc atgaattcat actctgttgc ctcctctctc     2580

cctgcctcac atctcccttc cacctcacaa ctccttccat ccttgactga agcgaacatc     2640

ttcatataaa ctcaagtgcc tgctacacat acaacactga aaaaaggaaa aaaaaagaaa     2700

aaaaaaaaaa accgc                                                      2715


<210>  9
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence from Alignment of Wildtype TrkA Protein Isoform A and 
       Wildtype TrkA Protein Isoform B

<400>  9

Leu Tyr Ile Glu Asn Gln Gln His Leu Gln His Leu Glu Leu Arg Asp 
1               5                   10                  15      


Leu Arg Gly Leu Gly Glu Leu Arg Asn Leu Thr Ile Val Lys Ser Gly 
            20                  25                  30          


Leu Arg Phe Val Ala Pro Asp Ala Phe His Phe Thr Pro Arg Leu Ser 
        35                  40                  45              


Arg Leu Asn Leu Ser Phe Asn Ala Leu Glu Ser Leu Ser Trp Lys Thr 
    50                  55                  60                  


Val Gln Gly Leu Ser Leu Gln Glu Leu Val Leu Ser Gly Asn Pro Leu 
65                  70                  75                  80  


His Cys Ser Cys Ala Leu Arg Trp Leu Gln Arg Trp Glu Glu Glu Gly 
                85                  90                  95      


Leu Gly Gly Val Pro Glu Gln Lys Leu Gln Cys His Gly Gln Gly Pro 
            100                 105                 110         


Leu Ala His Met Pro Asn Ala Ser Cys Gly Val Pro Thr Leu Lys Val 
        115                 120                 125             


Gln Val Pro Asn Ala Ser Val Asp Val Gly Asp Asp Val Leu Leu Arg 
    130                 135                 140                 


Cys Gln Val Glu Gly Arg Gly Leu Glu Gln Ala Gly Trp Ile Leu Thr 
145                 150                 155                 160 


Glu Leu Glu Gln Ser Ala Thr Val Met Lys Ser Gly Gly Leu Pro Ser 
                165                 170                 175     


Leu Gly Leu Thr Leu Ala Asn Val Thr Ser Asp Leu Asn Arg Lys Asn 
            180                 185                 190         


Val Thr Cys Trp Ala Glu Asn Asp Val Gly Arg Ala Glu Val Ser Val 
        195                 200                 205             


Gln Val Asn Val Ser Phe Pro Ala Ser Val Gln Leu His Thr Ala Val 
    210                 215                 220                 


Glu Met His His Trp Cys Ile Pro Phe Ser Val Asp Gly Gln Pro Ala 
225                 230                 235                 240 


Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser Val Leu Asn Glu Thr Ser 
                245                 250                 255     


Phe Ile Phe Thr Glu Phe Leu Glu Pro Ala Ala Asn Glu Thr Val Arg 
            260                 265                 270         


His Gly Cys Leu Arg Leu Asn Gln Pro Thr His Val Asn Asn Gly Asn 
        275                 280                 285             


Tyr Thr Leu Leu Ala Ala Asn Pro Phe Gly Gln Ala Ser Ala Ser Ile 
    290                 295                 300                 


Met Ala Ala Phe Met Asp Asn Pro Phe Glu Phe Asn Pro Glu Asp Pro 
305                 310                 315                 320 


Ile Pro Asp Thr Asn Ser Thr Ser Gly Asp Pro Val Glu Lys Lys Asp 
                325                 330                 335     


Glu Thr Pro Phe Gly Val Ser Val Ala Val Gly Leu Ala Val Phe Ala 
            340                 345                 350         


Cys Leu Phe Leu Ser Thr Leu Leu Leu Val Leu Asn Lys Cys Gly Arg 
        355                 360                 365             


Arg Asn Lys Phe Gly Ile Asn Arg Pro Ala Val Leu Ala Pro Glu Asp 
    370                 375                 380                 


Gly Leu Ala Met Ser Leu His Phe Met Thr Leu Gly Gly Ser Ser Leu 
385                 390                 395                 400 


Ser Pro Thr Glu Gly Lys Gly Ser Gly Leu Gln Gly His Ile Ile Glu 
                405                 410                 415     


Asn Pro Gln Tyr Phe Ser Asp Ala Cys Val His His Ile Lys Arg Arg 
            420                 425                 430         


Asp Ile Val Leu Lys Trp Glu Leu Gly Glu Gly Ala Phe Gly Lys Val 
        435                 440                 445             


Phe Leu Ala Glu Cys His Asn Leu Leu Pro Glu Gln Asp Lys Met Leu 
    450                 455                 460                 


Val Ala Val Lys Ala Leu Lys Glu Ala Ser Glu Ser Ala Arg Gln Asp 
465                 470                 475                 480 


Phe Gln Arg Glu Ala Glu Leu Leu Thr Met Leu Gln His Gln His Ile 
                485                 490                 495     


Val Arg Phe Phe Gly Val Cys Thr Glu Gly Arg Pro Leu Leu Met Val 
            500                 505                 510         


Phe Glu Tyr Met Arg His Gly Asp Leu Asn Arg Phe Leu Arg Ser His 
        515                 520                 525             


Gly Pro Asp Ala Lys Leu Leu Ala Gly Gly Glu Asp Val Ala Pro Gly 
    530                 535                 540                 


Pro Leu Gly Leu Gly Gln Leu Leu Ala Val Ala Ser Gln Val Ala Ala 
545                 550                 555                 560 


Gly Met Val Tyr Leu Ala Gly Leu His Phe Val His Arg Asp Leu Ala 
                565                 570                 575     


Thr Arg Asn Cys Leu Val Gly Gln Gly Leu Val Val Lys Ile Gly Asp 
            580                 585                 590         


Phe Gly Met Ser Arg Asp Ile Tyr Ser Thr Asp Tyr Tyr Arg Val Gly 
        595                 600                 605             


Gly Arg Thr Met Leu Pro Ile Arg Trp Met Pro Pro Glu Ser Ile Leu 
    610                 615                 620                 


Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val Trp Ser Phe Gly Val Val 
625                 630                 635                 640 


Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln Pro Trp Tyr Gln Leu Ser 
                645                 650                 655     


Asn Thr Glu Ala Ile Asp Cys Ile Thr Gln Gly Arg Glu Leu Glu Arg 
            660                 665                 670         


Pro Arg Ala Cys Pro Pro Glu Val Tyr Ala Ile Met Arg Gly Cys Trp 
        675                 680                 685             


Gln Arg Glu Pro Gln Gln Arg His Ser Ile Lys Asp Val His Ala Arg 
    690                 695                 700                 


Leu Gln Ala Leu Ala Gln Ala Pro Pro Val Tyr Leu Asp Val Leu Gly 
705                 710                 715                 720 


