                         SEQUENCE LISTING

<110>  VOYAGER THERAPEUTICS, INC.
 
<120>  REGULATABLE EXPRESSION USING ADENO-ASSOCIATED VIRUS (AAV)

<130>  2057.1504PCT

<140>  PCT/US2016/XXXXXX
<141>  2016-10-28

<150>  62/247,365
<151>  2015-10-28

<150>  62/298,640
<151>  2016-02-23

<160>  791   

<170>  PatentIn version 3.5

<210>  1
<211>  2211
<212>  DNA
<213>  Adeno-associated virus 1

<400>  1
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg atccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

caatacctgt attacctgaa cagaactcaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210>  2
<211>  736
<212>  PRT
<213>  Adeno-associated virus 1

<400>  2

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  3
<211>  4718
<212>  DNA
<213>  Adeno-associated virus 1

<400>  3
ttgcccactc cctctctgcg cgctcgctcg ctcggtgggg cctgcggacc aaaggtccgc       60

agacggcaga gctctgctct gccggcccca ccgagcgagc gagcgcgcag agagggagtg      120

ggcaactcca tcactagggg taatcgcgaa gcgcctccca cgctgccgcg tcagcgctga      180

cgtaaattac gtcatagggg agtggtcctg tattagctgt cacgtgagtg cttttgcgac      240

attttgcgac accacgtggc catttagggt atatatggcc gagtgagcga gcaggatctc      300

cattttgacc gcgaaatttg aacgagcagc agccatgccg ggcttctacg agatcgtgat      360

caaggtgccg agcgacctgg acgagcacct gccgggcatt tctgactcgt ttgtgagctg      420

ggtggccgag aaggaatggg agctgccccc ggattctgac atggatctga atctgattga      480

gcaggcaccc ctgaccgtgg ccgagaagct gcagcgcgac ttcctggtcc aatggcgccg      540

cgtgagtaag gccccggagg ccctcttctt tgttcagttc gagaagggcg agtcctactt      600

ccacctccat attctggtgg agaccacggg ggtcaaatcc atggtgctgg gccgcttcct      660

gagtcagatt agggacaagc tggtgcagac catctaccgc gggatcgagc cgaccctgcc      720

caactggttc gcggtgacca agacgcgtaa tggcgccgga ggggggaaca aggtggtgga      780

cgagtgctac atccccaact acctcctgcc caagactcag cccgagctgc agtgggcgtg      840

gactaacatg gaggagtata taagcgcctg tttgaacctg gccgagcgca aacggctcgt      900

ggcgcagcac ctgacccacg tcagccagac ccaggagcag aacaaggaga atctgaaccc      960

caattctgac gcgcctgtca tccggtcaaa aacctccgcg cgctacatgg agctggtcgg     1020

gtggctggtg gaccggggca tcacctccga gaagcagtgg atccaggagg accaggcctc     1080

gtacatctcc ttcaacgccg cttccaactc gcggtcccag atcaaggccg ctctggacaa     1140

tgccggcaag atcatggcgc tgaccaaatc cgcgcccgac tacctggtag gccccgctcc     1200

gcccgcggac attaaaacca accgcatcta ccgcatcctg gagctgaacg gctacgaacc     1260

tgcctacgcc ggctccgtct ttctcggctg ggcccagaaa aggttcggga agcgcaacac     1320

catctggctg tttgggccgg ccaccacggg caagaccaac atcgcggaag ccatcgccca     1380

cgccgtgccc ttctacggct gcgtcaactg gaccaatgag aactttccct tcaatgattg     1440

cgtcgacaag atggtgatct ggtgggagga gggcaagatg acggccaagg tcgtggagtc     1500

cgccaaggcc attctcggcg gcagcaaggt gcgcgtggac caaaagtgca agtcgtccgc     1560

ccagatcgac cccacccccg tgatcgtcac ctccaacacc aacatgtgcg ccgtgattga     1620

cgggaacagc accaccttcg agcaccagca gccgttgcag gaccggatgt tcaaatttga     1680

actcacccgc cgtctggagc atgactttgg caaggtgaca aagcaggaag tcaaagagtt     1740

cttccgctgg gcgcaggatc acgtgaccga ggtggcgcat gagttctacg tcagaaaggg     1800

tggagccaac aaaagacccg cccccgatga cgcggataaa agcgagccca agcgggcctg     1860

cccctcagtc gcggatccat cgacgtcaga cgcggaagga gctccggtgg actttgccga     1920

caggtaccaa aacaaatgtt ctcgtcacgc gggcatgctt cagatgctgt ttccctgcaa     1980

gacatgcgag agaatgaatc agaatttcaa catttgcttc acgcacggga cgagagactg     2040

ttcagagtgc ttccccggcg tgtcagaatc tcaaccggtc gtcagaaaga ggacgtatcg     2100

gaaactctgt gccattcatc atctgctggg gcgggctccc gagattgctt gctcggcctg     2160

cgatctggtc aacgtggacc tggatgactg tgtttctgag caataaatga cttaaaccag     2220

gtatggctgc cgatggttat cttccagatt ggctcgagga caacctctct gagggcattc     2280

gcgagtggtg ggacttgaaa cctggagccc cgaagcccaa agccaaccag caaaagcagg     2340

acgacggccg gggtctggtg cttcctggct acaagtacct cggacccttc aacggactcg     2400

acaaggggga gcccgtcaac gcggcggacg cagcggccct cgagcacgac aaggcctacg     2460

accagcagct caaagcgggt gacaatccgt acctgcggta taaccacgcc gacgccgagt     2520

ttcaggagcg tctgcaagaa gatacgtctt ttgggggcaa cctcgggcga gcagtcttcc     2580

aggccaagaa gcgggttctc gaacctctcg gtctggttga ggaaggcgct aagacggctc     2640

ctggaaagaa acgtccggta gagcagtcgc cacaagagcc agactcctcc tcgggcatcg     2700

gcaagacagg ccagcagccc gctaaaaaga gactcaattt tggtcagact ggcgactcag     2760

agtcagtccc cgatccacaa cctctcggag aacctccagc aacccccgct gctgtgggac     2820

ctactacaat ggcttcaggc ggtggcgcac caatggcaga caataacgaa ggcgccgacg     2880

gagtgggtaa tgcctcagga aattggcatt gcgattccac atggctgggc gacagagtca     2940

tcaccaccag cacccgcacc tgggccttgc ccacctacaa taaccacctc tacaagcaaa     3000

tctccagtgc ttcaacgggg gccagcaacg acaaccacta cttcggctac agcaccccct     3060

gggggtattt tgatttcaac agattccact gccacttttc accacgtgac tggcagcgac     3120

tcatcaacaa caattgggga ttccggccca agagactcaa cttcaaactc ttcaacatcc     3180

aagtcaagga ggtcacgacg aatgatggcg tcacaaccat cgctaataac cttaccagca     3240

cggttcaagt cttctcggac tcggagtacc agcttccgta cgtcctcggc tctgcgcacc     3300

agggctgcct ccctccgttc ccggcggacg tgttcatgat tccgcaatac ggctacctga     3360

cgctcaacaa tggcagccaa gccgtgggac gttcatcctt ttactgcctg gaatatttcc     3420

cttctcagat gctgagaacg ggcaacaact ttaccttcag ctacaccttt gaggaagtgc     3480

ctttccacag cagctacgcg cacagccaga gcctggaccg gctgatgaat cctctcatcg     3540

accaatacct gtattacctg aacagaactc aaaatcagtc cggaagtgcc caaaacaagg     3600

acttgctgtt tagccgtggg tctccagctg gcatgtctgt tcagcccaaa aactggctac     3660

ctggaccctg ttatcggcag cagcgcgttt ctaaaacaaa aacagacaac aacaacagca     3720

attttacctg gactggtgct tcaaaatata acctcaatgg gcgtgaatcc atcatcaacc     3780

ctggcactgc tatggcctca cacaaagacg acgaagacaa gttctttccc atgagcggtg     3840

tcatgatttt tggaaaagag agcgccggag cttcaaacac tgcattggac aatgtcatga     3900

ttacagacga agaggaaatt aaagccacta accctgtggc caccgaaaga tttgggaccg     3960

tggcagtcaa tttccagagc agcagcacag accctgcgac cggagatgtg catgctatgg     4020

gagcattacc tggcatggtg tggcaagata gagacgtgta cctgcagggt cccatttggg     4080

ccaaaattcc tcacacagat ggacactttc acccgtctcc tcttatgggc ggctttggac     4140

tcaagaaccc gcctcctcag atcctcatca aaaacacgcc tgttcctgcg aatcctccgg     4200

cggagttttc agctacaaag tttgcttcat tcatcaccca atactccaca ggacaagtga     4260

gtgtggaaat tgaatgggag ctgcagaaag aaaacagcaa gcgctggaat cccgaagtgc     4320

agtacacatc caattatgca aaatctgcca acgttgattt tactgtggac aacaatggac     4380

tttatactga gcctcgcccc attggcaccc gttaccttac ccgtcccctg taattacgtg     4440

ttaatcaata aaccggttga ttcgtttcag ttgaactttg gtctcctgtc cttcttatct     4500

tatcggttac catggttata gcttacacat taactgcttg gttgcgcttc gcgataaaag     4560

acttacgtca tcgggttacc cctagtgatg gagttgccca ctccctctct gcgcgctcgc     4620

tcgctcggtg gggcctgcgg accaaaggtc cgcagacggc agagctctgc tctgccggcc     4680

ccaccgagcg agcgagcgcg cagagaggga gtgggcaa                             4718


<210>  4
<211>  3131
<212>  DNA
<213>  Adeno-associated virus

<400>  4
gcggccgcga attcgccctt ggctgcgtca actggaccaa tgagaacttt cccttcaatg       60

attgcgtcga caagatggtg atctggtggg aggagggcaa gatgacggcc aaggtcgtgg      120

agtccgccaa ggccattctc ggcggcagca aggtgcgcgt ggaccaaaag tgcaagtcgt      180

ccgcccagat cgaccccacc cccgtgatcg tcacctccaa caccaacatg tgcgccgtga      240

ttgacgggaa cagcaccacc ttcgagcacc agcagcctct ccaggaccgg atgtttaagt      300

tcgaactcac ccgccgtctg gagcacgact ttggcaaggt gacaaagcag gaagtcaaag      360

agttcttccg ctgggccagt gatcacgtga ccgaggtggc gcatgagttt tacgtcagaa      420

agggcggagc cagcaaaaga cccgcccccg atgacgcgga taaaagcgag cccaagcggg      480

cctgcccctc agtcgcggat ccatcgacgt cagacgcgga aggagctccg gtggactttg      540

ccgacaggta ccaaaacaaa tgttctcgtc acgcgggcat gcttcagatg ctgtttccct      600

gcaaaacgtg cgagagaatg aatcggaatt tcaacatttg cttcacacac ggggtcagag      660

actgctcaga gtgtttcccc ggcgtgtcag aatctcaacc ggtcgtcaga aagaggacgt      720

atcggaaact ccgtgcgatt catcatctgc tggggcgggc tcccgagatt gcttgctcgg      780

cctgcgatct ggtcaacgtg gacctggatg actgtgtttc tgagcaataa atgacttaaa      840

ccaggtatgg ctgccgatgg ttatcttcca gattggctcg aggacaacct ctctgagggc      900

attcgcgagt ggtgggcgct gaaacctgga gccccgaagc ccaaagccaa ccagcaaaag      960

caggacgacg gccggggtct ggtgcttcct ggctacaagt acctcggacc cttcaacgga     1020

ctcgacaagg gggagcccgt caacgcggcg gacgcagcgg ccctcgagca cgacaaggct     1080

tacgaccagc agctgcaggc gggtgacaat ccgtacctgc ggtataacca cgccgacgcc     1140

gagtttcagg agcgtctgca agaagatacg tcttttgggg gcaacctcgg gcgagcagtc     1200

ttccaggcca agaagcgggt tctcgaacct ctcggtctgg ttgaggaagg cgctaagacg     1260

gctcctggaa agaagagacc ggtagagcca tcaccccagc gttctccaga ctcctctacg     1320

ggcatcggca agaaaggcca acagcccgcc agaaaaagac tcaattttgg tcagactggc     1380

gactcagagt cagttccaga ccctcaacct ctcggagaac ctccagcagc gccctctggt     1440

gtgggaccta atacaatggc tgcaggcggt ggcgcaccaa tggcagacaa taacgaaggc     1500

gccgacggag tgggtagttc ctcgggaaat tggcattgcg attccacatg gctgggcgac     1560

agagtcatca ccaccagcac ccgaacctgg gccctgccca cctacaacaa ccacctctac     1620

aagcaaatct ccaacgggac atcgggagga gccaccaacg acaacaccta cttcggctac     1680

agcaccccct gggggtattt tgactttaac agattccact gccacctttc accacgtgac     1740

tggcagcgac tcatcaacaa caactgggga ttccgaccca agagactcag cttcaagctc     1800

ttcaacatcc aggtcaagga ggtcacgcag aatgaaggca ccaagaccat cgccaataac     1860

ctcaccagca ccatccaggt gtttacggac tcggagtacc agctgccgta cgttctcggc     1920

tctgtccacc agggctgcct gcctccgttc ccggcggacg tgttcatgat tccccagtac     1980

ggctacctaa cactcaacaa cggtagtcag gccgtgggac gctcctcctt ctactgcctg     2040

gaatactttc cttcgcagat gctgagaacc ggcaacaact tccagtttac ttacaccttc     2100

gaggacgtgc ctttccacag cagctacgcc cacagctaga gcttggaccg gctgatgaat     2160

cctctgattg accagtacct gtactacttg tctcggactc aaacaacagg aggcacggca     2220

aatacgcaga ctctgggctt cagccaaggt gggcctaata caatggccaa tcaggcaaag     2280

aactggctgc caggaccctg ttaccgccaa caacgcgtct caacgacaac cgggcaaaac     2340

aacaatagca actttgcctg gactgctggg accaaatacc atctgaatgg aagaaattca     2400

ttggctaatc ctggcatcgc tatggcaaca cacaaagacg acgaggagcg tttttttccc     2460

agtaacggga tcctgatttt tggcaaacaa aatgctgcca gagacaatgc ggattacagc     2520

gatgtcatgc tcaccagcga ggaagaaatc aaaaccacta accctgtggc tacagaggaa     2580

tacggtatcg tggcagataa cttgcagcag caaaacacgg ctcctcaaat tggaactgtc     2640

aacagccagg gggccttacc cggtatggtc tggcagaacc gggacgtgta cctgcagggt     2700

cccatctggg ccaagattcc tcacacggac ggcaacttcc acccgtctcc gctgatgggc     2760

ggctttggcc tgaaacatcc tccgcctcag atcctgatca agaacacgcc tgtacctgcg     2820

gatcctccga ccaccttcaa ccagtcaaag ctgaactctt tcatcacgca atacagcacc     2880

ggacaggtca gcgtggaaat tgaatgggag ctgcagaagg aaaacagcaa gcgctggaac     2940

cccgagatcc agtacacctc caactactac aaatctataa gtgtggactt tgctgttaat     3000

acagaaggcg tgtactctga accccgcccc attggcaccc gttacctcac ccgtaatctg     3060

taattgcctg ttaatcaata aaccggttga ttcgtttcag ttgaactttg gtctctgcga     3120

agggcgaatt c                                                          3131


<210>  5
<211>  255
<212>  DNA
<213>  Adeno-associated virus 10

<400>  5
ggtaattcct ccggaaattg gcattgcgat tccacatggc tgggcgacag agtcatcacc       60

accagcaccc gaacctgggt cctgcccacc tacaacaacc acatctacaa gcaaatctcc      120

agcgagacag gagccaccaa cgacaaccac tacttcggct acagcacccc ctgggggtat      180

tttgacttta acagattcca ctgccacttt tcaccacgtg actggcagcg actcatcaac      240

aacaactggg gattc                                                       255


<210>  6
<211>  738
<212>  PRT
<213>  Adeno-associated virus 10

<400>  6

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Glu Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Ala Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  7
<211>  738
<212>  PRT
<213>  Adeno-associated virus 10

<400>  7

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Asp 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  8
<211>  258
<212>  DNA
<213>  Adeno-associated virus 11

<400>  8
ggtaattcct ccggaaattg gcattgcgat tccacatggc tgggcgacag agtcatcacc       60

accagcaccc gaacctgggc cctgccaacc tacaacaacc acctctacaa acaaatctcc      120

agcgcttcaa cgggggccag caacgacaac cactactttg gctacagcac cccctggggg      180

tattttgact ttaacagatt ccactgccac ttctcaccac gtgactggca gcgactcatc      240

aacaacaact ggggattc                                                    258


<210>  9
<211>  255
<212>  DNA
<213>  Adeno-associated virus 12

<400>  9
ggtaattcct ccggaaattg gcattgcgat tccacatggc tgggcgaccg agtcattacc       60

accagcaccc ggacttgggc cctgcccacc tacaacaacc acctctacaa gcaaatctcc      120

agccaatcgg gtgccaccaa cgacaaccac tacttcggct acagcacccc ttgggggtat      180

tttgatttca acagattcca ctgccatttc tcaccacgtg actggcagcg actcatcaac      240

aacaactggg gattc                                                       255


<210>  10
<211>  2208
<212>  DNA
<213>  Adeno-associated virus 2

<400>  10
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  11
<211>  735
<212>  PRT
<213>  Adeno-associated virus 2

<400>  11

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  12
<211>  621
<212>  PRT
<213>  Adeno-associated virus 2

<400>  12

Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Gly His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Thr Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln 
        275                 280                 285             


Pro Val Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Thr Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val 
465                 470                 475                 480 


Glu His Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala 
                485                 490                 495     


Pro Ser Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys 
545                 550                 555                 560 


Phe Thr His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu 
                565                 570                 575     


Ser Gln Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr 
            580                 585                 590         


Ile His His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp 
        595                 600                 605             


Leu Val Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln 
    610                 615                 620     


<210>  13
<211>  4675
<212>  DNA
<213>  Adeno-associated virus 2

<400>  13
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgtatt agaggtcacg tgagtgtttt gcgacatttt gcgacaccat      240

gtggtcacgc tgggtattta agcccgagtg agcacgcagg gtctccattt tgaagcggga      300

ggtttgaacg cgcagccgcc atgccggggt tttacgagat tgtgattaag gtccccagcg      360

accttgacgg gcatctgccc ggcatttctg acagctttgt gaactgggtg gccgagaagg      420

aatgggagtt gccgccagat tctgacatgg atctgaatct gattgagcag gcacccctga      480

ccgtggccga gaagctgcag cgcgactttc tgacggaatg gcgccgtgtg agtaaggccc      540

cggaggccct tttctttgtg caatttgaga agggagagag ctacttccac atgcacgtgc      600

tcgtggaaac caccggggtg aaatccatgg ttttgggacg tttcctgagt cagattcgcg      660

aaaaactgat tcagagaatt taccgcggga tcgagccgac tttgccaaac tggttcgcgg      720

tcacaaagac cagaaatggc gccggaggcg ggaacaaggt ggtggatgag tgctacatcc      780

ccaattactt gctccccaaa acccagcctg agctccagtg ggcgtggact aatatggaac      840

agtatttaag cgcctgtttg aatctcacgg agcgtaaacg gttggtggcg cagcatctga      900

cgcacgtgtc gcagacgcag gagcagaaca aagagaatca gaatcccaat tctgatgcgc      960

cggtgatcag atcaaaaact tcagccaggt acatggagct ggtcgggtgg ctcgtggaca     1020

aggggattac ctcggagaag cagtggatcc aggaggacca ggcctcatac atctccttca     1080

atgcggcctc caactcgcgg tcccaaatca aggctgcctt ggacaatgcg ggaaagatta     1140

tgagcctgac taaaaccgcc cccgactacc tggtgggcca gcagcccgtg gaggacattt     1200

ccagcaatcg gatttataaa attttggaac taaacgggta cgatccccaa tatgcggctt     1260

ccgtctttct gggatgggcc acgaaaaagt tcggcaagag gaacaccatc tggctgtttg     1320

ggcctgcaac taccgggaag accaacatcg cggaggccat agcccacact gtgcccttct     1380

acgggtgcgt aaactggacc aatgagaact ttcccttcaa cgactgtgtc gacaagatgg     1440

tgatctggtg ggaggagggg aagatgaccg ccaaggtcgt ggagtcggcc aaagccattc     1500

tcggaggaag caaggtgcgc gtggaccaga aatgcaagtc ctcggcccag atagacccga     1560

ctcccgtgat cgtcacctcc aacaccaaca tgtgcgccgt gattgacggg aactcaacga     1620

ccttcgaaca ccagcagccg ttgcaagacc ggatgttcaa atttgaactc acccgccgtc     1680

tggatcatga ctttgggaag gtcaccaagc aggaagtcaa agactttttc cggtgggcaa     1740

aggatcacgt ggttgaggtg gagcatgaat tctacgtcaa aaagggtgga gccaagaaaa     1800

gacccgcccc cagtgacgca gatataagtg agcccaaacg ggtgcgcgag tcagttgcgc     1860

agccatcgac gtcagacgcg gaagcttcga tcaactacgc agacaggtac caaaacaaat     1920

gttctcgtca cgtgggcatg aatctgatgc tgtttccctg cagacaatgc gagagaatga     1980

atcagaattc aaatatctgc ttcactcacg gacagaaaga ctgtttagag tgctttcccg     2040

tgtcagaatc tcaacccgtt tctgtcgtca aaaaggcgta tcagaaactg tgctacattc     2100

atcatatcat gggaaaggtg ccagacgctt gcactgcctg cgatctggtc aatgtggatt     2160

tggatgactg catctttgaa caataaatga tttaaatcag gtatggctgc cgatggttat     2220

cttccagatt ggctcgagga cactctctct gaaggaataa gacagtggtg gaagctcaaa     2280

cctggcccac caccaccaaa gcccgcagag cggcataagg acgacagcag gggtcttgtg     2340

cttcctgggt acaagtacct cggacccttc aacggactcg acaagggaga gccggtcaac     2400

gaggcagacg ccgcggccct cgagcacgta caaagcctac gaccggcagc tcgacagcgg     2460

agacaacccg tacctcaagt acaaccacgc cgacgcggag tttcaggagc gccttaaaga     2520

agatacgtct tttgggggca acctcggacg agcagtcttc caggcgaaaa agagggttct     2580

tgaacctctg ggcctggttg aggaacctgt taagacggct ccgggaaaaa agaggccggt     2640

agagcactct cctgtggagc cagactcctc ctcgggaacc ggaaaggcgg gccagcagcc     2700

tgcaagaaaa agattgaatt ttggtcagac tggagacgca gactcagtac ctgaccccca     2760

gcctctcgga cagccaccag cagccccctc tggtctggga actaatacga tggctacagg     2820

cagtggcgca ccaatggcag acaataacga gggcgccgac ggagtgggta attcctccgg     2880

aaattggcat tgcgattcca catggatggg cgacagagtc atcaccacca gcacccgaac     2940

ctgggccctg cccacctaca acaaccacct ctacaaacaa atttccagcc aatcaggagc     3000

ctcgaacgac aatcactact ttggctacag caccccttgg gggtattttg acttcaacag     3060

attccactgc cacttttcac cacgtgactg gcaaagactc atcaacaaca actggggatt     3120

ccgacccaag agactcaact tcaagctctt taacattcaa gtcaaagagg tcacgcagaa     3180

tgacggtacg acgacgattg ccaataacct taccagcacg gttcaggtgt ttactgactc     3240

ggagtaccag ctcccgtacg tcctcggctc ggcgcatcaa ggatgcctcc cgccgttccc     3300

agcagacgtc ttcatggtgc cacagtatgg atacctcacc ctgaacaacg ggagtcaggc     3360

agtaggacgc tcttcatttt actgcctgga gtactttcct tctcagatgc tgcgtaccgg     3420

aaacaacttt accttcagct acacttttga ggacgttcct ttccacagca gctacgctca     3480

cagccagagt ctggaccgtc tcatgaatcc tctcatcgac cagtacctgt attacttgag     3540

cagaacaaac actccaagtg gaaccaccac gcagtcaagg cttcagtttt ctcaggccgg     3600

agcgagtgac attcgggacc agtctaggaa ctggcttcct ggaccctgtt accgccagca     3660

gcgagtatca aagacatctg cggataacaa caacagtgaa tactcgtgga ctggagctac     3720

caagtaccac ctcaatggca gagactctct ggtgaatccg gccatggcaa gccacaagga     3780

cgatgaagaa aagttttttc ctcagagcgg ggttctcatc tttgggaagc aaggctcaga     3840

gaaaacaaat gtgaacattg aaaaggtcat gattacagac gaagaggaaa tcggaacaac     3900

caatcccgtg gctacggagc agtatggttc tgtatctacc aacctccaga gaggcaacag     3960

acaagcagct accgcagatg tcaacacaca aggcgttctt ccaggcatgg tctggcagga     4020

cagagatgtg taccttcagg ggcccatctg ggcaaagatt ccacacacgg acggacattt     4080

tcacccctct cccctcatgg gtggattcgg acttaaacac cctcctccac agattctcat     4140

caagaacacc ccggtacctg cgaatccttc gaccaccttc agtgcggcaa agtttgcttc     4200

cttcatcaca cagtactcca cgggacacgg tcagcgtgga gatcgagtgg gagctgcaga     4260

aggaaaacag caaacgctgg aatcccgaaa ttcagtacac ttccaactac aacaagtctg     4320

ttaatcgtgg acttaccgtg gatactaatg gcgtgtattc agagcctcgc cccattggca     4380

ccagatacct gactcgtaat ctgtaattgc ttgttaatca ataaaccgtt taattcgttt     4440

cagttgaact ttggtctctg cgtatttctt tcttatctag tttccatggc tacgtagata     4500

agtagcatgg cgggttaatc attaactaca aggaacccct agtgatggag ttggccactc     4560

cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg     4620

gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg gccaa          4675


<210>  14
<211>  4679
<212>  DNA
<213>  Adeno-associated virus 2

<400>  14
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgtatt agaggtcacg tgagtgtttt gcgacatttt gcgacaccat      240

gtggtcacgc tgggtattta agcccgagtg agcacgcagg gtctccattt tgaagcggga      300

ggtttgaacg cgcagccgcc atgccggggt tttacgagat tgtgattaag gtccccagcg      360

accttgacgg gcatctgccc ggcatttctg acagctttgt gaactgggtg gccgagaagg      420

aatgggagtt gccgccagat tctgacatgg atctgaatct gattgagcag gcacccctga      480

ccgtggccga gaagctgcag cgcgactttc tgacggaatg gcgccgtgtg agtaaggccc      540

cggaggccct tttctttgtg caatttgaga agggagagag ctacttccac atgcacgtgc      600

tcgtggaaac caccggggtg aaatccatgg ttttgggacg tttcctgagt cagattcgcg      660

aaaaactgat tcagagaatt taccgcggga tcgagccgac tttgccaaac tggttcgcgg      720

tcacaaagac cagaaatggc gccggaggcg ggaacaaggt ggtggatgag tgctacatcc      780

ccaattactt gctccccaaa acccagcctg agctccagtg ggcgtggact aatatggaac      840

agtatttaag cgcctgtttg aatctcacgg agcgtaaacg gttggtggcg cagcatctga      900

cgcacgtgtc gcagacgcag gagcagaaca aagagaatca gaatcccaat tctgatgcgc      960

cggtgatcag atcaaaaact tcagccaggt acatggagct ggtcgggtgg ctcgtggaca     1020

aggggattac ctcggagaag cagtggatcc aggaggacca ggcctcatac atctccttca     1080

atgcggcctc caactcgcgg tcccaaatca aggctgcctt ggacaatgcg ggaaagatta     1140

tgagcctgac taaaaccgcc cccgactacc tggtgggcca gcagcccgtg gaggacattt     1200

ccagcaatcg gatttataaa attttggaac taaacgggta cgatccccaa tatgcggctt     1260

ccgtctttct gggatgggcc acgaaaaagt tcggcaagag gaacaccatc tggctgtttg     1320

ggcctgcaac taccgggaag accaacatcg cggaggccat agcccacact gtgcccttct     1380

acgggtgcgt aaactggacc aatgagaact ttcccttcaa cgactgtgtc gacaagatgg     1440

tgatctggtg ggaggagggg aagatgaccg ccaaggtcgt ggagtcggcc aaagccattc     1500

tcggaggaag caaggtgcgc gtggaccaga aatgcaagtc ctcggcccag atagacccga     1560

ctcccgtgat cgtcacctcc aacaccaaca tgtgcgccgt gattgacggg aactcaacga     1620

ccttcgaaca ccagcagccg ttgcaagacc ggatgttcaa atttgaactc acccgccgtc     1680

tggatcatga ctttgggaag gtcaccaagc aggaagtcaa agactttttc cggtgggcaa     1740

aggatcacgt ggttgaggtg gagcatgaat tctacgtcaa aaagggtgga gccaagaaaa     1800

gacccgcccc cagtgacgca gatataagtg agcccaaacg ggtgcgcgag tcagttgcgc     1860

agccatcgac gtcagacgcg gaagcttcga tcaactacgc agacaggtac caaaacaaat     1920

gttctcgtca cgtgggcatg aatctgatgc tgtttccctg cagacaatgc gagagaatga     1980

atcagaattc aaatatctgc ttcactcacg gacagaaaga ctgtttagag tgctttcccg     2040

tgtcagaatc tcaacccgtt tctgtcgtca aaaaggcgta tcagaaactg tgctacattc     2100

atcatatcat gggaaaggtg ccagacgctt gcactgcctg cgatctggtc aatgtggatt     2160

tggatgactg catctttgaa caataaatga tttaaatcag gtatggctgc cgatggttat     2220

cttccagatt ggctcgagga cactctctct gaaggaataa gacagtggtg gaagctcaaa     2280

cctggcccac caccaccaaa gcccgcagag cggcataagg acgacagcag gggtcttgtg     2340

cttcctgggt acaagtacct cggacccttc aacggactcg acaagggaga gccggtcaac     2400

gaggcagacg ccgcggccct cgagcacgac aaagcctacg accggcagct cgacagcgga     2460

gacaacccgt acctcaagta caaccacgcc gacgcggagt ttcaggagcg ccttaaagaa     2520

gatacgtctt ttgggggcaa cctcggacga gcagtcttcc aggcgaaaaa gagggttctt     2580

gaacctctgg gcctggttga ggaacctgtt aagacggctc cgggaaaaaa gaggccggta     2640

gagcactctc ctgtggagcc agactcctcc tcgggaaccg gaaaggcggg ccagcagcct     2700

gcaagaaaaa gattgaattt tggtcagact ggagacgcag actcagtacc tgacccccag     2760

cctctcggac agccaccagc agccccctct ggtctgggaa ctaatacgat ggctacaggc     2820

agtggcgcac caatggcaga caataacgag ggcgccgacg gagtgggtaa ttcctccgga     2880

aattggcatt gcgattccac atggatgggc gacagagtca tcaccaccag cacccgaacc     2940

tgggccctgc ccacctacaa caaccacctc tacaaacaaa tttccagcca atcaggagcc     3000

tcgaacgaca atcactactt tggctacagc accccttggg ggtattttga cttcaacaga     3060

ttccactgcc acttttcacc acgtgactgg caaagactca tcaacaacaa ctggggattc     3120

cgacccaaga gactcaactt caagctcttt aacattcaag tcaaagaggt cacgcagaat     3180

gacggtacga cgacgattgc caataacctt accagcacgg ttcaggtgtt tactgactcg     3240

gagtaccagc tcccgtacgt cctcggctcg gcgcatcaag gatgcctccc gccgttccca     3300

gcagacgtct tcatggtgcc acagtatgga tacctcaccc tgaacaacgg gagtcaggca     3360

gtaggacgct cttcatttta ctgcctggag tactttcctt ctcagatgct gcgtaccgga     3420

aacaacttta ccttcagcta cacttttgag gacgttcctt tccacagcag ctacgctcac     3480

agccagagtc tggaccgtct catgaatcct ctcatcgacc agtacctgta ttacttgagc     3540

agaacaaaca ctccaagtgg aaccaccacg cagtcaaggc ttcagttttc tcaggccgga     3600

gcgagtgaca ttcgggacca gtctaggaac tggcttcctg gaccctgtta ccgccagcag     3660

cgagtatcaa agacatctgc ggataacaac aacagtgaat actcgtggac tggagctacc     3720

aagtaccacc tcaatggcag agactctctg gtgaatccgg gcccggccat ggcaagccac     3780

aaggacgatg aagaaaagtt ttttcctcag agcggggttc tcatctttgg gaagcaaggc     3840

tcagagaaaa caaatgtgga cattgaaaag gtcatgatta cagacgaaga ggaaatcagg     3900

acaaccaatc ccgtggctac ggagcagtat ggttctgtat ctaccaacct ccagagaggc     3960

aacagacaag cagctaccgc agatgtcaac acacaaggcg ttcttccagg catggtctgg     4020

caggacagag atgtgtacct tcaggggccc atctgggcaa agattccaca cacggacgga     4080

cattttcacc cctctcccct catgggtgga ttcggactta aacaccctcc tccacagatt     4140

ctcatcaaga acaccccggt acctgcgaat ccttcgacca ccttcagtgc ggcaaagttt     4200

gcttccttca tcacacagta ctccacggga caggtcagcg tggagatcga gtgggagctg     4260

cagaaggaaa acagcaaacg ctggaatccc gaaattcagt acacttccaa ctacaacaag     4320

tctgttaatg tggactttac tgtggacact aatggcgtgt attcagagcc tcgccccatt     4380

ggcaccagat acctgactcg taatctgtaa ttgcttgtta atcaataaac cgtttaattc     4440

gtttcagttg aactttggtc tctgcgtatt tctttcttat ctagtttcca tggctacgta     4500

gataagtagc atggcgggtt aatcattaac tacaaggaac ccctagtgat ggagttggcc     4560

actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc     4620

ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcagagaggg agtggccaa      4679


<210>  15
<211>  725
<212>  PRT
<213>  Adeno-associated virus 5

<400>  15

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg 
    130                 135                 140                 


Ile Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp 
145                 150                 155                 160 


Ser Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser 
                165                 170                 175     


Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp 
            180                 185                 190         


Thr Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly 
        195                 200                 205             


Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr 
    210                 215                 220                 


Trp Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu 
225                 230                 235                 240 


Pro Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val 
                245                 250                 255     


Asp Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly 
            260                 265                 270         


Tyr Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp 
        275                 280                 285             


Gln Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg 
    290                 295                 300                 


Val Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser 
305                 310                 315                 320 


Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr 
                325                 330                 335     


Asp Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly 
            340                 345                 350         


Cys Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly 
        355                 360                 365             


Tyr Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser 
    370                 375                 380                 


Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly 
385                 390                 395                 400 


Asn Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser 
                405                 410                 415     


Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val 
            420                 425                 430         


Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val 
        435                 440                 445             


Gln Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn 
    450                 455                 460                 


Trp Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser 
465                 470                 475                 480 


Gly Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met 
                485                 490                 495     


Glu Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met 
            500                 505                 510         


Thr Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met 
        515                 520                 525             


Ile Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu 
    530                 535                 540                 


Glu Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn 
545                 550                 555                 560 


Arg Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser 
                565                 570                 575     


Ser Thr Thr Ala Pro Thr Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val 
            580                 585                 590         


Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile 
        595                 600                 605             


Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala 
    610                 615                 620                 


Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys 
625                 630                 635                 640 


Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val 
                645                 650                 655     


Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met 
            660                 665                 670         


Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile 
        675                 680                 685             


Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro 
    690                 695                 700                 


Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr 
705                 710                 715                 720 


Leu Thr Arg Pro Leu 
                725 


<210>  16
<211>  644
<212>  PRT
<213>  Adeno-associated virus


<220>
<221>  MOD_RES
<222>  (434)..(434)
<223>  Xaa = any amino acid

<400>  16

Lys Ala Tyr Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg 
1               5                   10                  15      


Tyr Asn His Ala Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr 
            20                  25                  30          


Ser Phe Gly Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg 
        35                  40                  45              


Val Leu Glu Pro Leu Gly Leu Val Glu Thr Pro Ala Lys Thr Ala Pro 
    50                  55                  60                  


Gly Lys Lys Arg Pro Val Asp Ser Pro Asp Ser Thr Ser Gly Ile Gly 
65                  70                  75                  80  


Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                85                  90                  95      


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            100                 105                 110         


Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly 
        115                 120                 125             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    130                 135                 140                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
145                 150                 155                 160 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                165                 170                 175     


Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn Val 
            180                 185                 190         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        195                 200                 205             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    210                 215                 220                 


Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln 
225                 230                 235                 240 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                245                 250                 255     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            260                 265                 270         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        275                 280                 285             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    290                 295                 300                 


Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
305                 310                 315                 320 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                325                 330                 335     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            340                 345                 350         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg 
        355                 360                 365             


Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln Phe 
    370                 375                 380                 


Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp Leu 
385                 390                 395                 400 


Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp Gln 
                405                 410                 415     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu 
            420                 425                 430         


Asn Xaa Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr His 
        435                 440                 445             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe 
    450                 455                 460                 


Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu Met 
465                 470                 475                 480 


Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu Glu 
                485                 490                 495     


Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Ser Thr Ala Ala Gln 
            500                 505                 510         


Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        515                 520                 525             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    530                 535                 540                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
545                 550                 555                 560 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                565                 570                 575     


Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            580                 585                 590         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        595                 600                 605             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    610                 615                 620                 


Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly Val 
625                 630                 635                 640 


Tyr Ser Glu Pro 
                


<210>  17
<211>  1933
<212>  DNA
<213>  Adeno-associated virus

<400>  17
caaggcctac gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc       60

cgacgccgag tttcaggagt gtcttcaaga agatacgtct tttgggggca acctcgggcg      120

agcagtcttc caggccaaaa agcgggttct cgaacctctt ggtctggttg agacgccagc      180

taagacggca cctggaaaga agcgaccggt agactcgcca gactccacct cgggcatcgg      240

caagaaaggc cagcagcccg cgaaaaagag actcaacttt gggcagactg gcgactcaga      300

gtcagtcccc gaccctcaac caatcggaga accaccagca ggcccctctg gtctgggatc      360

tggtacaatg gttgcaggcg gtggcgcacc aatggctgac aataacgagg gcgccgacgg      420

agtgggtaat gcctcaggaa attggcattg cgattccaca tggctgggcg acagagtcat      480

caccaccagc acccgaacct gggccctgcc cacctacaac aaccacctct acaagcaaat      540

ctccagtcag tcagcaggga gcaccaacga taacgtctat ttcggctaca gcaccccctg      600

ggggtatttt gacttcaaca gattccattg ccacttctca ccacgtgact ggcagcgact      660

tatcaacaac aactggggat tccggcccaa gaagctcaac ttcaagctct tcaacatcca      720

ggtcaaggag gtcacgacga atgacggtgt cacaaccatc gctaataacc ttaccagcac      780

ggttcaggtc ttttcggact cggaatatca actgccgtac gtcctcggct ccgcgcacca      840

gggctgcctg cctccgttcc cggcagacgt gttcatgatt ccgcagtacg gatacctgac      900

tctgaacaat ggcagccaat cggtaggccg ttcctccttc tactgcctgg agtactttcc      960

ttctcagatg ctgagaacgg gcaacaactt cacctttagc tacaccttcg aggacgtgcc     1020

tttccacagc agctacgcgc acagccagag tctggaccgg ctgatgaatc ccctcatcga     1080

ccagtacctg tactacttgg ccagaacaca gagcaacgca ggaggtactg ctggcaatcg     1140

ggaactgcag ttttatcagg gcggacctac caccatggcc gaacaagcaa agaactggct     1200

gcccggacct tgcttccggc aacagagagt atccaagacg ctggatcaaa ataacaacag     1260

caactttgcc tggactggtg ccacaaaata ccatttaaat ggaagaaatt cattggttaa     1320

tcccggtgtc gccatggcaa cccacaagga cgacgaggaa cgcttctccc cttcgagcgg     1380

agttctaatt tttggcaaaa ctggagcagc taataaaact acattagaaa acgtgctcat     1440

gacaaatgaa gaagaaattc gtcctaccaa cccggtagct accgaggaat acgggattgt     1500

aagcagcaac ttgcaggcgg ctagcaccgc agcccagaca caagttgtta acaaccaggg     1560

agccttacct ggcatggtct ggcagaaccg ggacgtgtac ctgcaaggtc ccatttgggc     1620

caagattcct cacacggacg gcaactttca cccgtctcct ctaatgggtg gctttggact     1680

gaaacacccg cctccccaga tcctgatcaa aaacacgccg gtacctgcta atcctccaga     1740

agtgtttact cctgccaagt ttgcttcctt catcacgcag tacagcaccg ggcaagtcag     1800

cgttgagatc gagtgggagc tgcagaaaga gaacagcaag cgctggaacc cagagattca     1860

gtacacctcc aactttgaca aacagactgg agtggacttt gctgttgaca gccagggtgt     1920

ttactctgag cct                                                        1933


<210>  18
<211>  644
<212>  PRT
<213>  Adeno-associated virus

<400>  18

Lys Ala Tyr Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg 
1               5                   10                  15      


Tyr Asn His Ala Asp Ala Glu Phe Gln Glu Cys Leu Gln Glu Asp Thr 
            20                  25                  30          


Ser Phe Gly Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg 
        35                  40                  45              


Val Leu Glu Pro Leu Gly Leu Val Glu Thr Pro Ala Lys Thr Ala Pro 
    50                  55                  60                  


Gly Lys Lys Arg Pro Val Asp Ser Pro Asp Ser Thr Ser Gly Ile Gly 
65                  70                  75                  80  


Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                85                  90                  95      


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            100                 105                 110         


Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Val Ala Gly Gly Gly 
        115                 120                 125             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    130                 135                 140                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
145                 150                 155                 160 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                165                 170                 175     


Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn Val 
            180                 185                 190         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        195                 200                 205             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    210                 215                 220                 


Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln 
225                 230                 235                 240 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                245                 250                 255     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            260                 265                 270         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        275                 280                 285             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    290                 295                 300                 


Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
305                 310                 315                 320 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                325                 330                 335     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            340                 345                 350         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg 
        355                 360                 365             


Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln Phe 
    370                 375                 380                 


Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp Leu 
385                 390                 395                 400 


Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp Gln 
                405                 410                 415     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu 
            420                 425                 430         


Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr His 
        435                 440                 445             


Lys Asp Asp Glu Glu Arg Phe Ser Pro Ser Ser Gly Val Leu Ile Phe 
    450                 455                 460                 


Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu Met 
465                 470                 475                 480 


Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu Glu 
                485                 490                 495     


Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Ser Thr Ala Ala Gln 
            500                 505                 510         


Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        515                 520                 525             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    530                 535                 540                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
545                 550                 555                 560 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                565                 570                 575     


Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            580                 585                 590         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        595                 600                 605             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    610                 615                 620                 


Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly Val 
625                 630                 635                 640 


Tyr Ser Glu Pro 
                


<210>  19
<211>  1933
<212>  DNA
<213>  Adeno-associated virus

<400>  19
caaggcctac gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc       60

cgacgccgag tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg      120

agcagtcttc caggccaaaa agcgggttct cgaacctctt ggtctggttg agacgccagc      180

taagacggca cctggaaaga agcgaccggt agactcgcca gactccacct cgggcatcgg      240

caagaaaggc cagcagcccg cgaaaaagag actcaacttt gggcagactg gcgactcaga      300

gccagtcccc gaccctcaac caatcggaga accaccagca ggcccctctg gtctgggatc      360

tggtacaatg gctgcaggcg gtggcgcacc aatggctgac aataacgagg gcgccgacgg      420

agtgggtaat gcctcaggaa attggcattg cgattccaca cggctgggcg acagagtcat      480

caccaccagc acccgaacct gggccctgcc cacctacaac aaccacctct acaagcaaat      540

ctccagtcag tcagcaggga gcaccaacga taacgtctat ttcggctaca gcaccccctg      600

ggggtatttt gacttcaaca gattccattg ccacttctca ccacgtgact ggcagcgact      660

tatcaacaac aactggggat tccggcccaa gaagctcaac ttcaagctct tcaacatcca      720

ggtcaaggag gtcacgacga atgacggcgt cacaaccatc gctaataacc ttaccagcac      780

ggttcaggtc ttttcggact cggaatatca actgccgtac gtcctcggct ccgcgcacca      840

gggctgcctg cctccgttcc cggcagacgt gttcatgatt ccgcagtacg gatacctgac      900

tctgaacaat ggcagccaat cggtaggccg ttcctccttc tactgcctgg agtactttcc      960

ttctcagatg ctgagaacgg gcaacaactt cacctttagc tacaccttcg aggacgtgcc     1020

tttccacagc agctacgcgc acagccagag tctgggccgg ctgatgaatc ccctcatcga     1080

ccagtacctg tactacttgg ccagaacaca gagcaacgca ggaggtactg ctggcaatcg     1140

ggaactgcag ttttatcagg gcggacctac caccatggcc gaacaagcaa agaactggct     1200

gcccggacct tgcttccggc aacagagagt atccaagacg ctggatcaaa ataacaacag     1260

caactttgcc tggactggtg ccacaaaata ccatttaaat ggaagaaatt cattggttaa     1320

tcccggtgtc gccatggcaa cccacaagga cgacgaggaa cgcttcttcc cttcgagcgg     1380

agttctaatt tttggcaaaa ctggagcagc taataaaact acattagaaa acgtgctcat     1440

gacaaatgaa gaagaaattc gtcctaccaa cccggtagct accgaggaat acgggattgt     1500

aagcagcaac ttgcaggcgg ctagcaccgc agcccagaca caagttgtta acaaccaggg     1560

agccttacct ggcatggtct ggcagaaccg ggacgtgtac ctgcaaggtc ccatttgggc     1620

caagattcct cacacggacg gcaactttca cccgtctcct ctaatgggtg gctttggact     1680

gaaacacccg cctccccaga tcctgatcaa aaacacaccg gtacctgcta atcctccaga     1740

agtgtttact cctgccaagt ttgcttcctt catcacgcag tacagcaccg ggcaagtcag     1800

cgttgagatc gaatgggagc tgcagaaaga gaacagcaag cgctggaacc cagagattca     1860

gtacacctcc aactttgaca aacagactgg agtggacttt gctgttgaca gccagggtgt     1920

ttactctgag cct                                                        1933


<210>  20
<211>  644
<212>  PRT
<213>  Adeno-associated virus

<400>  20

Lys Ala Tyr Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg 
1               5                   10                  15      


Tyr Asn His Ala Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr 
            20                  25                  30          


Ser Phe Gly Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg 
        35                  40                  45              


Val Leu Glu Pro Leu Gly Leu Val Glu Thr Pro Ala Lys Thr Ala Pro 
    50                  55                  60                  


Gly Lys Lys Arg Pro Val Asp Ser Pro Asp Ser Thr Ser Gly Ile Gly 
65                  70                  75                  80  


Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                85                  90                  95      


Gly Asp Ser Glu Pro Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            100                 105                 110         


Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly 
        115                 120                 125             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    130                 135                 140                 


Ser Gly Asn Trp His Cys Asp Ser Thr Arg Leu Gly Asp Arg Val Ile 
145                 150                 155                 160 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                165                 170                 175     


Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn Val 
            180                 185                 190         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        195                 200                 205             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    210                 215                 220                 


Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln 
225                 230                 235                 240 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                245                 250                 255     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            260                 265                 270         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        275                 280                 285             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    290                 295                 300                 


Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
305                 310                 315                 320 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                325                 330                 335     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Gly 
            340                 345                 350         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg 
        355                 360                 365             


Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln Phe 
    370                 375                 380                 


Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp Leu 
385                 390                 395                 400 


Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp Gln 
                405                 410                 415     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu 
            420                 425                 430         


Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr His 
        435                 440                 445             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe 
    450                 455                 460                 


Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu Met 
465                 470                 475                 480 


Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu Glu 
                485                 490                 495     


Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Ser Thr Ala Ala Gln 
            500                 505                 510         


Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        515                 520                 525             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    530                 535                 540                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
545                 550                 555                 560 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                565                 570                 575     


Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            580                 585                 590         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        595                 600                 605             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    610                 615                 620                 


Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly Val 
625                 630                 635                 640 


Tyr Ser Glu Pro 
                


<210>  21
<211>  1933
<212>  DNA
<213>  Adeno-associated virus

<400>  21
caaggcctac gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc       60

cgacgccgag tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg      120

agcagtcttc caggccaaaa agcgggttct cgaacctctt ggtctggttg agacgccagc      180

taagacggca cctggaaaga agcgaccggt agactcgcca gactccacct cgggcatcgg      240

caagaaaggc cagcagcccg cgaaaaagag actcaacttt gggcagactg gcgactcaga      300

gccagtcccc gaccctcaac caatcggaga accaccagca ggcccctctg gtctgggatc      360

tggtacaatg gctgcaggcg gtggcgcacc aatggctgac aataacgagg gcgccgacgg      420

agtgggtaat gcctcaggaa attggcattg cgattccaca cggctgggcg acagagtcat      480

caccaccagc acccgaacct gggccctgcc cacctacaac aaccacctct acaagcaaat      540

ctccagtcag tcagcaggga gcaccaacga taacgtctat ttcggctaca gcaccccctg      600

ggggtatttt gacttcaaca gattccattg ccacttctca ccacgtgact ggcagcgact      660

tatcaacaac aactggggat tccggcccaa gaagctcaac ttcaagctct tcaacatcca      720

ggtcaaggag gtcacgacga atgacggcgt cacaaccatc gctaataacc ttaccagcac      780

ggttcaggtc ttttcggact cggaatatca actgccgtac gtcctcggct ccgcgcacca      840

gggctgcctg cctccgttcc cggcagacgt gttcatgatt ccgcagtacg gatacctgac      900

tctgaacaat ggcagccaat cggtaggccg ttcctccttc tactgcctgg agtactttcc      960

ttctcagatg ctgagaacgg gcaacaactt cacctttagc tacaccttcg aggacgtgcc     1020

tttccacagc agctacgcgc acagccagag tctgggccgg ctgatgaatc ccctcatcga     1080

ccagtacctg tactacttgg ccagaacaca gagcaacgca ggaggtactg ctggcaatcg     1140

ggaactgcag ttttatcagg gcggacctac caccatggcc gaacaagcaa agaactggct     1200

gcccggacct tgcttccggc aacagagagt atccaagacg ctggatcaaa ataacaacag     1260

caactttgcc tggactggtg ccacaaaata ccatttaaat ggaagaaatt cattggttaa     1320

tcccggtgtc gccatggcaa cccacaagga cgacgaggaa cgcttcttcc cttcgagcgg     1380

agttctaatt tttggcaaaa ctggagcagc taataaaact acattagaaa acgtgctcat     1440

gacaaatgaa gaagaaattc gtcctaccaa cccggtagct accgaggaat acgggattgt     1500

aagcagcaac ttgcaggcgg ctagcaccgc agcccagaca caagttgtta acaaccaggg     1560

agccttacct ggcatggtct ggcagaaccg ggacgtgtac ctgcaaggtc ccatttgggc     1620

caagattcct cacacggacg gcaactttca cccgtctcct ctaatgggtg gctttggact     1680

gaaacacccg cctccccaga tcctgatcaa aaacacaccg gtacctgcta atcctccaga     1740

agtgtttact cctgccaagt ttgcttcctt catcacgcag tacagcaccg ggcaagtcag     1800

cgttgagatc gaatgggagc tgcagaaaga gaacagcaag cgctggaacc cagagattca     1860

gtacacctcc aactttgaca aacagactgg agtggacttt gctgttgaca gccagggtgt     1920

ttactctgag cct                                                        1933


<210>  22
<211>  644
<212>  PRT
<213>  Adeno-associated virus

<400>  22

Lys Ala Tyr Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg 
1               5                   10                  15      


Tyr Asn His Ala Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr 
            20                  25                  30          


Ser Phe Gly Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg 
        35                  40                  45              


Val Leu Glu Pro Leu Gly Leu Val Glu Thr Pro Ala Lys Thr Ala Pro 
    50                  55                  60                  


Gly Lys Lys Arg Pro Val Asp Ser Pro Asp Ser Thr Ser Gly Ile Gly 
65                  70                  75                  80  


Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                85                  90                  95      


Gly Asp Ser Glu Pro Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            100                 105                 110         


Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly 
        115                 120                 125             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    130                 135                 140                 


Ser Gly Asn Trp His Cys Asp Ser Thr Arg Leu Gly Asp Arg Val Ile 
145                 150                 155                 160 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                165                 170                 175     


Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn Val 
            180                 185                 190         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        195                 200                 205             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    210                 215                 220                 


Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln 
225                 230                 235                 240 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                245                 250                 255     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            260                 265                 270         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        275                 280                 285             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    290                 295                 300                 


Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
305                 310                 315                 320 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                325                 330                 335     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Gly 
            340                 345                 350         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg 
        355                 360                 365             


Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln Phe 
    370                 375                 380                 


Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp Leu 
385                 390                 395                 400 


Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp Gln 
                405                 410                 415     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu 
            420                 425                 430         


Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr His 
        435                 440                 445             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe 
    450                 455                 460                 


Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu Met 
465                 470                 475                 480 


Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu Glu 
                485                 490                 495     


Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Ser Thr Ala Ala Gln 
            500                 505                 510         


Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        515                 520                 525             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    530                 535                 540                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
545                 550                 555                 560 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                565                 570                 575     


Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            580                 585                 590         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        595                 600                 605             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    610                 615                 620                 


Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly Val 
625                 630                 635                 640 


Tyr Ser Glu Pro 
                


<210>  23
<211>  1933
<212>  DNA
<213>  Adeno-associated virus

<400>  23
caaggcctac gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc       60

cgacgccgag tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg      120

agcagtcttc caggccaaaa agcgggttct cgaacctctt ggtctggttg agacgccagc      180

taagacggca cctggaaaga agcgaccggt agactcgcca gactccacct cgggcatcgg      240

caagaaaggc cagcagcccg cgaaaaagag actcaacttt gggcagactg gcgactcaga      300

gtcagtcccc gaccctcaac caatcggaga accaccagca ggcccctctg gtctgggatc      360

tggtacaatg gctgcaggcg gtggcgcacc aatggctgac aatagcgagg gcgccgacgg      420

agtgggtaat gcctcaggaa attggcattg cgattccaca tggctgggcg acagagtcat      480

caccaccagc acccgaacct gggccctgcc cacctacaac aaccacctct acaagcaaat      540

ctccagtcag tcagcaggga gcaccaacga taacgtctat ttcggctaca gcaccccctg      600

ggggtatttt gacttcaaca gattccattg ccacttctca ccacgtgact ggcagcgact      660

tatcaacaac aactggggat tccggcccaa gaagctcaac ttcaagctct tcaacatcca      720

ggtcaaggag gtcacgacga atgacggtgt cacaaccatc gctaataacc ttaccagcac      780

ggttcaggtc ttttcggact cggaatatca actgccgtac gtcctcggct ccgcgcacca      840

gggctgcctg cctccgttcc cggcagacgt gttcatgatt ccgcagtacg gatacctgac      900

tctgaacaat ggcagccaat cggtaggccg ttcctccttc tactgcctgg agtactttcc      960

ttctcagatg ctgagaacgg gcaacaactt cacctttagc tacaccttcg aggacgtgcc     1020

tttccacagc agctacgcgc acagccagag tctggaccgg ctgatgaatc ccctcatcga     1080

ccagtacctg tactacttgg ccagaacaca gagcaacgca ggaggtactg ctggcaatcg     1140

ggaactgcag ttttatcagg gcggacctac caccatggcc gaacaagcaa agaactggct     1200

gcccggacct tgcttccggc aacagagagt atccaagacg ctggatcaaa ataacaacag     1260

caactttgcc tggactggtg ccacaaaata ccatttaaat ggaagaaatt cattggttaa     1320

tcccggtgtc gccatggcaa cccacaagga cgacgaggaa cgcttcttcc cttcgagcgg     1380

agttctaatt tttggcaaaa ctggagcagc taataaaact acattagaaa acgtgctcat     1440

gacaaatgaa gaagaaattc gtcctaccaa cccggtagct accgaggaat acgggattgt     1500

aagcagcaac ttgcaggcgg ctagcaccgc agcccagaca caagttgtta acaaccaggg     1560

agccttacct ggcatggtct ggcagaaccg ggacgtgtac ctgcaaggtc ccatttgggc     1620

caagattcct cacacggacg gcaactttca cccgtctcct ctaatgggtg gctttggact     1680

gaaacacccg cctccccaga tcctgatcaa aaacacaccg gtacctgcta atcctccaga     1740

agtgtttact cctgccaagc ttgcttcctt catcacgcag tacagcaccg ggcaagtcag     1800

cgttgagatc gagtgggagc tgcagaaaga gaacagcaag cgctggaacc cagagattca     1860

gtacacctcc aactttgaca aacagactgg agtggacttt gctgttgaca gccagggtgt     1920

ttactctgag cct                                                        1933


<210>  24
<211>  644
<212>  PRT
<213>  Adeno-associated virus

<400>  24

Lys Ala Tyr Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg 
1               5                   10                  15      


Tyr Asn His Ala Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr 
            20                  25                  30          


Ser Phe Gly Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg 
        35                  40                  45              


Val Leu Glu Pro Leu Gly Leu Val Glu Thr Pro Ala Lys Thr Ala Pro 
    50                  55                  60                  


Gly Lys Lys Arg Pro Val Asp Ser Pro Asp Ser Thr Ser Gly Ile Gly 
65                  70                  75                  80  


Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                85                  90                  95      


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            100                 105                 110         


Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly 
        115                 120                 125             


Ala Pro Met Ala Asp Asn Ser Glu Gly Ala Asp Gly Val Gly Asn Ala 
    130                 135                 140                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
145                 150                 155                 160 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                165                 170                 175     


Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn Val 
            180                 185                 190         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        195                 200                 205             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    210                 215                 220                 


Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln 
225                 230                 235                 240 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                245                 250                 255     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            260                 265                 270         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        275                 280                 285             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    290                 295                 300                 


Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
305                 310                 315                 320 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                325                 330                 335     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            340                 345                 350         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg 
        355                 360                 365             


Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln Phe 
    370                 375                 380                 


Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp Leu 
385                 390                 395                 400 


Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp Gln 
                405                 410                 415     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu 
            420                 425                 430         


Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr His 
        435                 440                 445             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe 
    450                 455                 460                 


Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu Met 
465                 470                 475                 480 


Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu Glu 
                485                 490                 495     


Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Ser Thr Ala Ala Gln 
            500                 505                 510         


Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        515                 520                 525             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    530                 535                 540                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
545                 550                 555                 560 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                565                 570                 575     


Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Leu Ala Ser Phe Ile Thr 
            580                 585                 590         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        595                 600                 605             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    610                 615                 620                 


Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly Val 
625                 630                 635                 640 


Tyr Ser Glu Pro 
                


<210>  25
<211>  1933
<212>  DNA
<213>  Adeno-associated virus

<400>  25
caaggcctac gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc       60

cgacgccgag tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg      120

agcagtcttc caggccaaaa agcgggttct cgaacctctt ggtctggttg agacgccagc      180

taagacggca cctggaaaga agcgaccggt agactcgcca gactccacct cgggcatcgg      240

caagaaaggc cagcagcccg cgaaaaagag actcaacttt gggcagactg gcgactcaga      300

gtcagtcccc gaccctcaac caatcggaga accaccagca ggcccctctg gtctgggatc      360

tggtacaatg gctgcaggcg gtggcgcacc aatggctgac aataacgagg gcgccgacgg      420

agtgggtaat gcctcaggaa attggcattg cgattccaca tggctgggcg acagagtcat      480

caccaccagc acccgaacct gggccctgcc cacctacaac aaccacctct acaagcaaat      540

ctccagtcag tcagcaggga gcaccaacga taacgtctat ttcggctaca gcaccccctg      600

ggggtatttt gacttcaaca gattccattg ccacttctca ccacgtgact ggcagcgact      660

tatcaacaac aactggggat tccggcccaa gaagctcaac ttcaagctct tcaacatcca      720

ggtcaaggag gtcacgacga atgacggcgt cacaaccatc gctaataacc ttaccagcac      780

ggttcaggtc ttttcggacc cggaatatca actgccgtac gtcctcggct ccgcgcacca      840

gggctgcctg cctccgttcc cggcagacgt gttcatgatt ccgcagtacg gatacctgac      900

tctgaacaat ggcagccaat cggtaggccg ttcctccttc tactgcctgg agtactttcc      960

ttctcagatg ctgagaacgg gcaacaactt cacctttagc tacaccttcg aggacgtgcc     1020

tttccacagc agctacgcgc acagccagag tctggaccgg ctgatgaatc ccctcatcga     1080

ccagtacctg tactacttgg ccagaacaca gagcaacgca ggaggtactg ctggcaatcg     1140

ggaactgcag ttttatcagg gcggacctac caccatggcc gaacaagcaa agaactggct     1200

gcccggacct tgcttccggc aacagagagt atccaagacg ctggatcaaa ataacaacag     1260

caactttgcc tggactggtg ccacaaaata ccatttaaat ggaagaaatt cattggttaa     1320

tcccggtgtc gccatggcaa cccacaagga cgacgaggaa cgcttcttcc cttcgagcgg     1380

agttctaatt tttggcaaaa ctggagcagc taataaaact acattagaaa acgtgctcat     1440

gacaaatgaa gaagaaattc gtcctaccaa cccggtagct accgaggaat acgggattgt     1500

aagcagcaac ttgcaggcgg ctagcaccgc agcccagaca caagttgtta acaaccaggg     1560

agccttacct ggcatggtct ggcagaaccg ggacgtgtac ctgcaaggtc ccatttgggc     1620

caagattcct cacacggacg gcaactttca cccgtctcct ctaatgggtg gctttggact     1680

gaaacacccg cctccccaga tcctgatcaa aaacacaccg gtacctgcta atcctccaga     1740

agtgtttact cctgccaaga ttgcttcctt catcacgcag tacagcaccg ggcaagtcag     1800

cgttgagatc gagtgggagc tgcagaaaga gaacagcaag cgctggaacc cagagattca     1860

gtacacctcc aactttgaca aacagactgg agtggacttt gctgttgaca gccagggtgt     1920

ttactctgag cct                                                        1933


<210>  26
<211>  644
<212>  PRT
<213>  Adeno-associated virus

<400>  26

Lys Ala Tyr Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg 
1               5                   10                  15      


Tyr Asn His Ala Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr 
            20                  25                  30          


Ser Phe Gly Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg 
        35                  40                  45              


Val Leu Glu Pro Leu Gly Leu Val Glu Thr Pro Ala Lys Thr Ala Pro 
    50                  55                  60                  


Gly Lys Lys Arg Pro Val Asp Ser Pro Asp Ser Thr Ser Gly Ile Gly 
65                  70                  75                  80  


Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                85                  90                  95      


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            100                 105                 110         


Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly 
        115                 120                 125             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    130                 135                 140                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
145                 150                 155                 160 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                165                 170                 175     


Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn Val 
            180                 185                 190         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        195                 200                 205             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    210                 215                 220                 


Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln 
225                 230                 235                 240 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                245                 250                 255     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Pro Glu Tyr Gln Leu Pro 
            260                 265                 270         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        275                 280                 285             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    290                 295                 300                 


Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
305                 310                 315                 320 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                325                 330                 335     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            340                 345                 350         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg 
        355                 360                 365             


Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln Phe 
    370                 375                 380                 


Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp Leu 
385                 390                 395                 400 


Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp Gln 
                405                 410                 415     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu 
            420                 425                 430         


Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr His 
        435                 440                 445             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe 
    450                 455                 460                 


Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu Met 
465                 470                 475                 480 


Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu Glu 
                485                 490                 495     


Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Ser Thr Ala Ala Gln 
            500                 505                 510         


Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        515                 520                 525             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    530                 535                 540                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
545                 550                 555                 560 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                565                 570                 575     


Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Ile Ala Ser Phe Ile Thr 
            580                 585                 590         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        595                 600                 605             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    610                 615                 620                 


Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly Val 
625                 630                 635                 640 


Tyr Ser Glu Pro 
                


<210>  27
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  27

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Thr Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala Arg Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Gly Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Asp 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  28
<211>  3121
<212>  DNA
<213>  Adeno-associated virus

<400>  28
gaattcgccc ttctacggct gcgtcaactg gaccaatgag aactttccct tcaacgactg       60

tgtcgacaag atggtgatct ggtgggagga ggggaagatg accgccaagg tcgtggagtc      120

ggccaaagcc attctcggag gaagcaaggt gcgcgtggac cagaaatgca agtcctcggc      180

ccagatagac ccgactcccg tgatcgtcac ctccaacacc aacatgtgcg ccgtgattga      240

cgggaactca acgaccttcg aacaccagca gccgttgcaa gaccggatgt tcaaatttga      300

actcacccgc cgtctggatc atgactttgg gaaggtcacc aagcaggaag tcaaagactt      360

tttccggtgg gcaaaggatc acgtggttga ggtggagcac gaattctacg tcaaaaaggg      420

tggagccaag aaaagacccg cccccagtga cgcagatata agtgagccca aacgggtgcg      480

cgagtcagtt gcgcagccat cgacgtcaga cgcggaagct tcgatcaact acgcagacag      540

gtaccaaaac aaatgttctc gtcacgcggg catgaatctg atgctgtttc cctgcagaca      600

atgcgagaga atgaatcaga attcaaatat ctgcttcact cacggacaga aagactgttt      660

agagtgcttt cccgtgtcag aatctcaacc cgtttctgtc gtcaaaaagg cgtatcagaa      720

actgtgctac attcatcata tcatgggaaa ggtgccagac gcttgcactg cctgcgatct      780

ggtcgatgtg gatttggatg actgcatctt tgaacaataa atgatttaaa tcaggtatgg      840

ctgccgatgg ttatcttcca gattggctcg aggacaacct ctctgagggc attcgcgagt      900

ggtgggcgct gaaacctgga gccccgaagc ccaaagccaa ccagcaaaag caggacggcg      960

gccggggtct ggtgcttcct ggctacaagt acctcggacc cttcaacgga ctcgacaagg     1020

gggagcccgt caacgcggcg gacgcagcgg ccctcgagca cgacaaggcc tacgaccagc     1080

agctcaaagc gggtgacaat ccgtacctgc ggtataacca cgccgacgcc gagtttcagg     1140

agcgtctgca agaagatacg tcttttgggg gcaacctcgg gcgagcagtc ttccaggcca     1200

agaagcgggt tctcgaacct ctcggtctgg ttgaggaagg cgctaagacg gctcctggaa     1260

agaagagacc ggtagagcca tcaccccagc gttctccaga ctcctctacg ggcatcggca     1320

agaaaggcca gcagcccgcg aaaaagagac tcaactttgg gcagactggc gactcagagt     1380

cagtgcccga ccctcaacca atcggagaac cccccgcagg cccctctggt ctgggatctg     1440

gtacaatggc tgcaggcggt ggcgctccaa tggcagacaa taacgaaggc gccgacggag     1500

tgggtagttc ctcaggaaat tggcattgcg attccacatg gctgggcgac tgagtcatca     1560

ccaccagcac ccgaacctgg gccctcccca cctacaacaa ccacctctac aagcaaatct     1620

ccaacgggac ttcgggagga agcaccaacg acaacaccta cttcggctac agcaccccct     1680

gggggtattt tgactttaac agattccact gccacttctc accacgtgac tggcagcgac     1740

tcatcaacaa caactgggga ttccggccca agagactcaa cttcaagctc ttcaacatcc     1800

aggtcaagga ggtcacgcag aatgaaggca ccaagaccat cgccaataac cttaccagca     1860

cgattcaggt ctttacggac tcggaatacc agctcccgta cgtcctcggc tctgcgcacc     1920

agggctgcct gcctccgttc ccggcggacg tcttcatgat tcctcagtac gggtacctga     1980

ctctgaacaa tggcagtcag gccgtgggcc gttcctcctt ctactgcctg gagtactttc     2040

cttctcaaat gctgagaacg ggcaacaact ttgagttcag ctaccagttt gaggacgtgc     2100

cttttcacag cagctacgcg cacagccaaa gcctggaccg gctgatgaac cccctcatcg     2160

accagtacct gtactacctg tctcggactc agtccacggg aggtaccgca ggaactcagc     2220

agttgctatt ttctcaggcc gggcctaata acatgtcggc tcaggccaaa aactggctac     2280

ccgggccctg ctaccggcag taacgcgtct ccacgacact gtcgcaaaat aacaacagca     2340

actttgtctg gaccggtgcc accaagtatc atctgaatgg cagagactct ctggtagatc     2400

ccggtgtcgc tatggcaacc cacaaggacg acgaagagcg attttttccg tccagcggag     2460

tcataatgtt tgggaaacag ggagctggaa aagacaacgt ggactatagc agcgtcatgc     2520

taaccagtga ggaagaaatt aaaaccacca acccagtggc cacagaacag tacggcgtgg     2580

tggccgataa cctgcaacag caaaacgccg ctcctattgt aggggccgtc aacagtcaag     2640

gagccttacc tggcatggtc tggcagaacc gggacgtgta cctgcagggt cctacctggg     2700

ccaagattcc tcacacggac ggaaactttc atccctcgcc gctgatggga ggctttggac     2760

tgaaacaccc gcctcctcag atcctgatta agaatacacc tgttcccgcg gatcctccaa     2820

ctaccttcag tcaagctaag ctggcgtcgt tcatcacgca gtacagcacc ggacaggtca     2880

gcgtggaaat tgaatgggag ctgcaggaag aaaacagcaa acgctggaac ccagagattc     2940

aatacacttc caactactac aaatctacaa atgtggactt tgctgttaac acagatggca     3000

cttattctga gcctcgcccc atcggcaccc gttacctcac ccgtaatctg taattgcttg     3060

ttaatcaata aaccggttga ttcgtttcag ttgaactttg gtctctgcga agggcgaatt     3120

c                                                                     3121


<210>  29
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  29

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Gly Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Ser Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asp Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Asp 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  30
<211>  3121
<212>  DNA
<213>  Adeno-associated virus

<400>  30
gaattcgccc ttcgcgagac caaagttcaa ctgaaacgaa tcaaccggtt tattgattaa       60

caagcaatta cagattacgg gtgaggtaac gggtgccgat ggggcgaggc tcagaataag      120

tgccatctgt gttaacagca aagtccacat ttgtagattt gtagtagttg gaagtgtatt      180

gaatctctgg gttccagcgt ttgctgtttt ctttctgcag ctcccattca atttccacgc      240

tgacctgtcc ggtgctgtac tgcgtgatga acgacgccag cttagcttga ctgaaggtag      300

ttggaggatc cgcgggaaca ggtgtattct taatcaggat ctgaggaggc gggtgtttca      360

gtccaaagcc tcccatcagc ggcgagggat gaaagtttcc gtccgtgtga ggaatcttgg      420

cccagatagg accctgcagg tacacgtccc ggttctgcca gaccatgcca ggtaaggctc      480

cttgactgtt gacggcccct acaataggag cggcgttttg ctgttgcagg ttatcggcca      540

ccacgccgta ctgttctgtg gccactgggt tggtggtttt aatttcttcc tcactggtta      600

gcataacgct gctatagtcc acgttgtctt ttccagctcc ctgtttccca aacattaaga      660

ctccgctgga cggaaaaaat cgctcttcgt cgtccttgtg ggttgccata gcgacaccgg      720

gatttaccag agagtctctg ccattcagat gatacttggt ggcaccggtc caggcaaagt      780

tgctgttgtc attttgcgac agtgtcgtgg agacgcgttg ctgccggtag cagggcccgg      840

gtagccagtt tttggcctga gccgacatgt tattaggccc ggcctgagaa aatagcaact      900

gctgagttcc tgcggtacct cccgtggact gagtccgaga caggtagtac aggtactggt      960

cgatgagggg gttcatcagc cggtccaggc tttggctgtg cgcgtagctg ctgtgaaaag     1020

gcacgtcctc aaactggtag ctgaactcaa agttgttgcc cgttctcagc atttgagaag     1080

gaaagtactc caggcagtag aaggaggaac ggcccacggc ctgactgcca ttgttcagag     1140

tcaggtaccc gtactgagga atcatgaaga cgtccgccgg gaacggaggc aggcagccct     1200

ggtgcgcaga gccgaggacg tacgggagct ggtattccga gtccgtaaag acctgaatcg     1260

tgctggtaag gttattggcg atggtcttgg tgccttcatt ctgcgtgacc tccttgacct     1320

ggatgttgaa gagcttgaag ttgaggctct tgggccggaa tccccagttg ttgttgatga     1380

gtcgctgcca gtcacgtggt gagaagtggc agtggaatct gttaaagtca aaataccccc     1440

agggggtgct gtagccgaag taggtgttgt cgttggtgct tcctcccgaa gtcccgttgg     1500

agatttgctt gtagaggtgg ttgttgtagg tggggagggc ccaggttcgg gtgctggtgg     1560

tgatgactcc gtcgcccagc catgtggaat cgcaatgcca atttcctgag gaactaccca     1620

ctccgtcggc gccttcgtta ttgtctgcca ttggagcgcc accgcctgca gccattgtac     1680

cagatcccag accagagggg cctgcggggg gttctccgat tggttgaggg tcgggcactg     1740

actctgagtc gccagtctgc ccaaagttga gtctcttttt cgcgggctgc tggcctttct     1800

tgccgatgcc cgtagaggag tctggagaac gctggggtga tggctctacc ggtctcttct     1860

ttccaggagc cgtcttagcg ccttcctcaa ccagaccgag aggttcgaga acccgcttct     1920

tggcctggaa gactgctcgc ccgaggttgc ccccaaaaga cgtatcttct tgcagacgct     1980

cctgaaactc ggcgtcggcg tggttatacc gcaggtacgg attgtcaccc gctttgagct     2040

gctggtcgta ggccttgtcg tgctcgaggg ccgctgcgtc cgccgcgttg acgggctccc     2100

ccttgtcgag tccgttgaag ggtccgaggt acttgtagcc aggaagcacc agaccccggc     2160

cgtcgtcctg cttttgctgg ttggctttgg gcttcggggc tccaggtttc agcgcccacc     2220

actcgcgaat gccctcagag aggttgtcct cgagccaatc tggaagataa ccatcggcag     2280

ccatacctga tttaaatcat ttattgttca aagatgcagt catccaaatc cacattgacc     2340

agatcgcagg cagtgcaagc gtctggcacc tttcccatga tatgatgaat gtagcacagt     2400

ttctgatacg cctttttgac gacagaaacg ggttgagatt ctgacacggg aaagcactct     2460

aaacagtctt tctgtccgtg agtgaagcag atatttgaat tctgattcat tctctcgcat     2520

tgtctgcagg gaaacagcat cagattcatg cccacgtgac gagaacattt gttttggtac     2580

ctgtctgcgt agttgatcga agcttccgcg tctgacgtcg atggctgcgc aactgactcg     2640

cgcacccgtt tgggctcact tatatctgcg tcactggggg cgggtctttt cttggctcca     2700

ccctttttga cgtagaattc atgctccacc tcaaccacgt gatcctttgc ccaccggaaa     2760

aagtctttga cttcctgctt ggtgaccttc ccaaagtcat gatccagacg gcgggtgagt     2820

tcaaatttga acatccggtc ttgcaacggc tgctggtgtt cgaaggtcgt tgagttcccg     2880

tcaatcacgg cgcacatgtt ggtgttggag gtgacgatca cgggagtcgg gtctatctgg     2940

gccgaggact tgcatttctg gtccacgcgc accttgcttc ctccgagaat ggctttggcc     3000

gactccacga ccttggcggt catcttcccc tcctcccacc agatcaccat cttgtcgaca     3060

cagtcgttga agggaaagtt ctcattggtc cagttgacgc agccgtagaa agggcgaatt     3120

c                                                                     3121


<210>  31
<211>  2211
<212>  DNA
<213>  Adeno-associated virus

<400>  31
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcgt       60

gagtggtggg ctctgaaacc tggagtccct caacccaaag cgaaccaaca acaccaggac      120

aaccgtcggg gtcttgtgct tccgggttac aaatacctcg gacccggtaa cggactcgac      180

aaaggagagc cggtcaacga ggcggacgcg gcagccctcg aacacgacaa agcttacgac      240

cagcagctca aggccggtga caacccgtac ctcaagtaca accacgccga cgccgagttt      300

caggagcgtc ttcaagaaga tacgtctttt gggggcaacc ttggcagagc agtcttccag      360

gccaaaaaga ggatccttga gcctcttggt ctggttgagg aagcagctaa aacggctcct      420

ggaaagaagg gggctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg agactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca ccagaacctg ggccctgccc acttacaaca accatctcta caagcaaatc      780

tccagccaat caggagcttc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact ttaacagatt ccactgccac ttctcaccac gtgactggca gcgactcatt      900

aacaacaact ggggattccg gcccaagaaa ctcagcttca agctcttcaa catccaagtt      960

agaggggtca cgcagaacga tggcacgacg actattgcca ataaccttac cagcacggtt     1020

caagtgttta cggactcgga gtatcagctc ccgtacgtgc tcgggtcggc gcaccaaggc     1080

tgtctcccgc cgtttccagc ggacgtcttc atggtccctc agtatggata cctcaccctg     1140

aacaacggaa gtcaagcggt gggacgctca tccttttact gcctggagta cttcccttcg     1200

cagatgctaa ggactggaaa taacttccaa ttcagctata ccttcgagga tgtacctttt     1260

cacagcagct acgctcacag ccagagtttg gatcgcttga tgaatcctct tattgatcag     1320

tatctgtact acctgaacag aacgcaagga acaacctctg gaacaaccaa ccaatcacgg     1380

ctgcttttta gccaggctgg gcctcagtct atgtctttgc aggccagaaa ttggctacct     1440

gggccctgct accggcaaca gagactttca aagactgcta acgacaacaa caacagtaac     1500

tttccttgga cagcggccag caaatatcat ctcaatggcc gcgactcgct ggtgaatcca     1560

ggaccagcta tggccagtca caaggacgat gaagaaaaat ttttccctat gcacggcaat     1620

ctaatatttg gcaaagaagg gacaacggca agtaacgcag aattagataa tgtaatgatt     1680

acggatgaag aagagattcg taccaccaat cctgtggcaa cagagcagta tggaactgtg     1740

gcaaataact tgcagagctc aaatacagct cccacgactg gaactgtcaa tcatcagggg     1800

gccttacctg gcatggtgtg gcaagatcgt gacgtgtacc ttcaaggacc tatctgggca     1860

aagattcctc acacggatgg acactttcat ccttctcctc tgatgggagg ctttggactg     1920

aaacatccgc ctcctcaaat catgatcaaa aatactccgg taccggcaaa tcctccgacg     1980

actttcagcc cggccaagtt tgcttcattt atcactcagt actccactgg acaggtcagc     2040

gtggaaattg agtgggagct acagaaagaa aacagcaaac gttggaatcc agagattcag     2100

tacacttcca actacaacaa gtctgttaat gtggacttta ctgtagacac taatggtgtt     2160

tatagtgaac ctcgccctat tggaacccgg tatctcacac gaaacttgtg a              2211


<210>  32
<211>  736
<212>  PRT
<213>  Adeno-associated virus 3

<400>  32

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Gly 
    130                 135                 140                 


Ala Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Arg Gly Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  33
<211>  4726
<212>  DNA
<213>  Adeno-associated virus 3

<400>  33
ttggccactc cctctatgcg cactcgctcg ctcggtgggg cctggcgacc aaaggtcgcc       60

agacggacgt gctttgcacg tccggcccca ccgagcgagc gagtgcgcat agagggagtg      120

gccaactcca tcactagagg tatggcagtg acgtaacgcg aagcgcgcga agcgagacca      180

cgcctaccag ctgcgtcagc agtcaggtga cccttttgcg acagtttgcg acaccacgtg      240

gccgctgagg gtatatattc tcgagtgagc gaaccaggag ctccattttg accgcgaaat      300

ttgaacgagc agcagccatg ccggggttct acgagattgt cctgaaggtc ccgagtgacc      360

tggacgagcg cctgccgggc atttctaact cgtttgttaa ctgggtggcc gagaaggaat      420

gggacgtgcc gccggattct gacatggatc cgaatctgat tgagcaggca cccctgaccg      480

tggccgaaaa gcttcagcgc gagttcctgg tggagtggcg ccgcgtgagt aaggccccgg      540

aggccctctt ttttgtccag ttcgaaaagg gggagaccta cttccacctg cacgtgctga      600

ttgagaccat cggggtcaaa tccatggtgg tcggccgcta cgtgagccag attaaagaga      660

agctggtgac ccgcatctac cgcggggtcg agccgcagct tccgaactgg ttcgcggtga      720

ccaaaacgcg aaatggcgcc gggggcggga acaaggtggt ggacgactgc tacatcccca      780

actacctgct ccccaagacc cagcccgagc tccagtgggc gtggactaac atggaccagt      840

atttaagcgc ctgtttgaat ctcgcggagc gtaaacggct ggtggcgcag catctgacgc      900

acgtgtcgca gacgcaggag cagaacaaag agaatcagaa ccccaattct gacgcgccgg      960

tcatcaggtc aaaaacctca gccaggtaca tggagctggt cgggtggctg gtggaccgcg     1020

ggatcacgtc agaaaagcaa tggattcagg aggaccaggc ctcgtacatc tccttcaacg     1080

ccgcctccaa ctcgcggtcc cagatcaagg ccgcgctgga caatgcctcc aagatcatga     1140

gcctgacaaa gacggctccg gactacctgg tgggcagcaa cccgccggag gacattacca     1200

aaaatcggat ctaccaaatc ctggagctga acgggtacga tccgcagtac gcggcctccg     1260

tcttcctggg ctgggcgcaa aagaagttcg ggaagaggaa caccatctgg ctctttgggc     1320

cggccacgac gggtaaaacc aacatcgcgg aagccatcgc ccacgccgtg cccttctacg     1380

gctgcgtaaa ctggaccaat gagaactttc ccttcaacga ttgcgtcgac aagatggtga     1440

tctggtggga ggagggcaag atgacggcca aggtcgtgga gagcgccaag gccattctgg     1500

gcggaagcaa ggtgcgcgtg gaccaaaagt gcaagtcatc ggcccagatc gaacccactc     1560

ccgtgatcgt cacctccaac accaacatgt gcgccgtgat tgacgggaac agcaccacct     1620

tcgagcatca gcagccgctg caggaccgga tgtttgaatt tgaacttacc cgccgtttgg     1680

accatgactt tgggaaggtc accaaacagg aagtaaagga ctttttccgg tgggcttccg     1740

atcacgtgac tgacgtggct catgagttct acgtcagaaa gggtggagct aagaaacgcc     1800

ccgcctccaa tgacgcggat gtaagcgagc caaaacggga gtgcacgtca cttgcgcagc     1860

cgacaacgtc agacgcggaa gcaccggcgg actacgcgga caggtaccaa aacaaatgtt     1920

ctcgtcacgt gggcatgaat ctgatgcttt ttccctgtaa aacatgcgag agaatgaatc     1980

aaatttccaa tgtctgtttt acgcatggtc aaagagactg tggggaatgc ttccctggaa     2040

tgtcagaatc tcaacccgtt tctgtcgtca aaaagaagac ttatcagaaa ctgtgtccaa     2100

ttcatcatat cctgggaagg gcacccgaga ttgcctgttc ggcctgcgat ttggccaatg     2160

tggacttgga tgactgtgtt tctgagcaat aaatgactta aaccaggtat ggctgctgac     2220

ggttatcttc cagattggct cgaggacaac ctttctgaag gcattcgtga gtggtgggct     2280

ctgaaacctg gagtccctca acccaaagcg aaccaacaac accaggacaa ccgtcggggt     2340

cttgtgcttc cgggttacaa atacctcgga cccggtaacg gactcgacaa aggagagccg     2400

gtcaacgagg cggacgcggc agccctcgaa cacgacaaag cttacgacca gcagctcaag     2460

gccggtgaca acccgtacct caagtacaac cacgccgacg ccgagtttca ggagcgtctt     2520

caagaagata cgtcttttgg gggcaacctt ggcagagcag tcttccaggc caaaaagagg     2580

atccttgagc ctcttggtct ggttgaggaa gcagctaaaa cggctcctgg aaagaagggg     2640

gctgtagatc agtctcctca ggaaccggac tcatcatctg gtgttggcaa atcgggcaaa     2700

cagcctgcca gaaaaagact aaatttcggt cagactggag actcagagtc agtcccagac     2760

cctcaacctc tcggagaacc accagcagcc cccacaagtt tgggatctaa tacaatggct     2820

tcaggcggtg gcgcaccaat ggcagacaat aacgagggtg ccgatggagt gggtaattcc     2880

tcaggaaatt ggcattgcga ttcccaatgg ctgggcgaca gagtcatcac caccagcacc     2940

agaacctggg ccctgcccac ttacaacaac catctctaca agcaaatctc cagccaatca     3000

ggagcttcaa acgacaacca ctactttggc tacagcaccc cttgggggta ttttgacttt     3060

aacagattcc actgccactt ctcaccacgt gactggcagc gactcattaa caacaactgg     3120

ggattccggc ccaagaaact cagcttcaag ctcttcaaca tccaagttag aggggtcacg     3180

cagaacgatg gcacgacgac tattgccaat aaccttacca gcacggttca agtgtttacg     3240

gactcggagt atcagctccc gtacgtgctc gggtcggcgc accaaggctg tctcccgccg     3300

tttccagcgg acgtcttcat ggtccctcag tatggatacc tcaccctgaa caacggaagt     3360

caagcggtgg gacgctcatc cttttactgc ctggagtact tcccttcgca gatgctaagg     3420

actggaaata acttccaatt cagctatacc ttcgaggatg taccttttca cagcagctac     3480

gctcacagcc agagtttgga tcgcttgatg aatcctctta ttgatcagta tctgtactac     3540

ctgaacagaa cgcaaggaac aacctctgga acaaccaacc aatcacggct gctttttagc     3600

caggctgggc ctcagtctat gtctttgcag gccagaaatt ggctacctgg gccctgctac     3660

cggcaacaga gactttcaaa gactgctaac gacaacaaca acagtaactt tccttggaca     3720

gcggccagca aatatcatct caatggccgc gactcgctgg tgaatccagg accagctatg     3780

gccagtcaca aggacgatga agaaaaattt ttccctatgc acggcaatct aatatttggc     3840

aaagaaggga caacggcaag taacgcagaa ttagataatg taatgattac ggatgaagaa     3900

gagattcgta ccaccaatcc tgtggcaaca gagcagtatg gaactgtggc aaataacttg     3960

cagagctcaa atacagctcc cacgactgga actgtcaatc atcagggggc cttacctggc     4020

atggtgtggc aagatcgtga cgtgtacctt caaggaccta tctgggcaaa gattcctcac     4080

acggatggac actttcatcc ttctcctctg atgggaggct ttggactgaa acatccgcct     4140

cctcaaatca tgatcaaaaa tactccggta ccggcaaatc ctccgacgac tttcagcccg     4200

gccaagtttg cttcatttat cactcagtac tccactggac aggtcagcgt ggaaattgag     4260

tgggagctac agaaagaaaa cagcaaacgt tggaatccag agattcagta cacttccaac     4320

tacaacaagt ctgttaatgt ggactttact gtagacacta atggtgttta tagtgaacct     4380

cgccctattg gaacccggta tctcacacga aacttgtgaa tcctggttaa tcaataaacc     4440

gtttaattcg tttcagttga actttggctc ttgtgcactt ctttatcttt atcttgtttc     4500

catggctact gcgtagataa gcagcggcct gcggcgcttg cgcttcgcgg tttacaactg     4560

ctggttaata tttaactctc gccatacctc tagtgatgga gttggccact ccctctatgc     4620

gcactcgctc gctcggtggg gcctggcgac caaaggtcgc cagacggacg tgctttgcac     4680

gtccggcccc accgagcgag cgagtgcgca tagagggagt ggccaa                    4726


<210>  34
<211>  737
<212>  PRT
<213>  Adeno-associated virus

<400>  34

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Asn Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Ala Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Val Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Glu Gln Ile Ser Ser Glu Thr Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asp Pro Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Ser Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Thr Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asp Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Glu Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  35
<211>  2211
<212>  DNA
<213>  Adeno-associated virus

<400>  35
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcgt       60

gagtggtggg ctctgaaacc tggagtccct caacccaaag cgaaccaaca acaccaggac      120

aaccgtcggg gtcttgtgct tccgggttac aaatacctcg gacccggtaa cggactcgac      180

aaaggagagc cggtcaacga ggcggacgcg gcagccctcg aacacgacaa agcttacgac      240

cagcagctca aggccggtga caacccgtac ctcaagtaca accacgccga cgccgagttt      300

caggagcgtc ttcaagaaga tacgtctttt gggggcaacc ttggcagagc agtcttccag      360

gccaaaaaga ggatccttga gcctcttggt ctggttgagg aagcagctaa aacggctcct      420

ggaaagaagg gggctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg agactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca ccagaacctg ggccctgccc acttacaaca accatctcta caagcaaatc      780

tccagccaat caggagcttc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact ttaacagatt ccactgccac ttctcaccac gtgactggca gcgactcatt      900

aacaacaact ggggattccg gcccaagaaa ctcagcttca agctcttcaa catccaagtt      960

agaggggtca cgcagaacga tggcacgacg actattgcca ataaccttac cagcacggtt     1020

caagtgttta cggactcgga gtatcagctc ccgtacgtgc tcgggtcggc gcaccaaggc     1080

tgtctcccgc cgtttccagc ggacgtcttc atggtccctc agtatggata cctcaccctg     1140

aacaacggaa gtcaagcggt gggacgctca tccttttact gcctggagta cttcccttcg     1200

cagatgctaa ggactggaaa taacttccaa ttcagctata ccttcgagga tgtacctttt     1260

cacagcagct acgctcacag ccagagtttg gatcgcttga tgaatcctct tattgatcag     1320

tatctgtact acctgaacag aacgcaagga acaacctctg gaacaaccaa ccaatcacgg     1380

ctgcttttta gccaggctgg gcctcagtct atgtctttgc aggccagaaa ttggctacct     1440

gggccctgct accggcaaca gagactttca aagactgcta acgacaacaa caacagtaac     1500

tttccttgga cagcggccag caaatatcat ctcaatggcc gcgactcgct ggtgaatcca     1560

ggaccagcta tggccagtca caaggacgat gaagaaaaat ttttccctat gcacggcaat     1620

ctaatatttg gcaaagaagg gacaacggca agtaacgcag aattagataa tgtaatgatt     1680

acggatgaag aagagattcg taccaccaat cctgtggcaa cagagcagta tggaactgtg     1740

gcaaataact tgcagagctc aaatacagct cccacgactg gaactgtcaa tcatcagggg     1800

gccttacctg gcatggtgtg gcaagatcgt gacgtgtacc ttcaaggacc tatctgggca     1860

aagattcctc acacggatgg acactttcat ccttctcctc tgatgggagg ctttggactg     1920

aaacatccgc ctcctcaaat catgatcaaa aatactccgg taccggcaaa tcctccgacg     1980

actttcagcc cggccaagtt tgcttcattt atcactcagt actccactgg acaggtcagc     2040

gtggaaattg agtgggagct acagaaagaa aacagcaaac gttggaatcc agagattcag     2100

tacacttcca actacaacaa gtctgttaat gtggacttta ctgtagacac taatggtgtt     2160

tatagtgaac ctcgccctat tggaacccgg tatctcacac gaaacttgta a              2211


<210>  36
<211>  736
<212>  PRT
<213>  Adeno-associated virus

<400>  36

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Gly 
    130                 135                 140                 


Ala Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Arg Gly Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  37
<211>  736
<212>  PRT
<213>  Adeno-associated virus 3A

<400>  37

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Gly 
    130                 135                 140                 


Ala Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Arg Gly Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  38
<211>  624
<212>  PRT
<213>  Adeno-associated virus 3A

<400>  38

Met Pro Gly Phe Tyr Glu Ile Val Leu Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu Arg Leu Pro Gly Ile Ser Asn Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Asp Val Pro Pro Asp Ser Asp Met Asp Pro Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Glu Phe Leu 
    50                  55                  60                  


Val Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Thr Tyr Phe His Leu His Val Leu Ile Glu 
                85                  90                  95      


Thr Ile Gly Val Lys Ser Met Val Val Gly Arg Tyr Val Ser Gln Ile 
            100                 105                 110         


Lys Glu Lys Leu Val Thr Arg Ile Tyr Arg Gly Val Glu Pro Gln Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Asp Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Asp Gln Tyr Leu 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Ser Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Ser Asn 
        275                 280                 285             


Pro Pro Glu Asp Ile Thr Lys Asn Arg Ile Tyr Gln Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Gln Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Glu Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Glu Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Ser Asp His Val Thr Asp Val 
465                 470                 475                 480 


Ala His Glu Phe Tyr Val Arg Lys Gly Gly Ala Lys Lys Arg Pro Ala 
                485                 490                 495     


Ser Asn Asp Ala Asp Val Ser Glu Pro Lys Arg Glu Cys Thr Ser Leu 
            500                 505                 510         


Ala Gln Pro Thr Thr Ser Asp Ala Glu Ala Pro Ala Asp Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Lys Thr Cys Glu Arg Met Asn Gln Ile Ser Asn Val Cys 
545                 550                 555                 560 


Phe Thr His Gly Gln Arg Asp Cys Gly Glu Cys Phe Pro Gly Met Ser 
                565                 570                 575     


Glu Ser Gln Pro Val Ser Val Val Lys Lys Lys Thr Tyr Gln Lys Leu 
            580                 585                 590         


Cys Pro Ile His His Ile Leu Gly Arg Ala Pro Glu Ile Ala Cys Ser 
        595                 600                 605             


Ala Cys Asp Leu Ala Asn Val Asp Leu Asp Asp Cys Val Ser Glu Gln 
    610                 615                 620                 


<210>  39
<211>  736
<212>  PRT
<213>  Adeno-associated virus 3B

<400>  39

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  40
<211>  624
<212>  PRT
<213>  Adeno-associated virus 3B

<400>  40

Met Pro Gly Phe Tyr Glu Ile Val Leu Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asn Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Pro Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Glu Phe Leu 
    50                  55                  60                  


Val Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Thr Tyr Phe His Leu His Val Leu Ile Glu 
                85                  90                  95      


Thr Ile Gly Val Lys Ser Met Val Val Gly Arg Tyr Val Ser Gln Ile 
            100                 105                 110         


Lys Glu Lys Leu Val Thr Arg Ile Tyr Arg Gly Val Glu Pro Gln Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Asp Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Asp Gln Tyr Leu 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Ser Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Ser Asn 
        275                 280                 285             


Pro Pro Glu Asp Ile Thr Lys Asn Arg Ile Tyr Gln Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Gln Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Glu Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Ser Asp His Val Thr Asp Val 
465                 470                 475                 480 


Ala His Glu Phe Tyr Val Arg Lys Gly Gly Ala Lys Lys Arg Pro Ala 
                485                 490                 495     


Ser Asn Asp Ala Asp Val Ser Glu Pro Lys Arg Gln Cys Thr Ser Leu 
            500                 505                 510         


Ala Gln Pro Thr Thr Ser Asp Ala Glu Ala Pro Ala Asp Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Lys Thr Cys Glu Arg Met Asn Gln Ile Ser Asn Val Cys 
545                 550                 555                 560 


Phe Thr His Gly Gln Arg Asp Cys Gly Glu Cys Phe Pro Gly Met Ser 
                565                 570                 575     


Glu Ser Gln Pro Val Ser Val Val Lys Lys Lys Thr Tyr Gln Lys Leu 
            580                 585                 590         


Cys Pro Ile His His Ile Leu Gly Arg Ala Pro Glu Ile Ala Cys Ser 
        595                 600                 605             


Ala Cys Asp Leu Ala Asn Val Asp Leu Asp Asp Cys Val Ser Glu Gln 
    610                 615                 620                 


<210>  41
<211>  4722
<212>  DNA
<213>  Adeno-associated virus 3B

<400>  41
tggccactcc ctctatgcgc actcgctcgc tcggtggggc ctggcgacca aaggtcgcca       60

gacggacgtg ctttgcacgt ccggccccac cgagcgagcg agtgcgcata gagggagtgg      120

ccaactccat cactagaggt atggcagtga cgtaacgcga agcgcgcgaa gcgagaccac      180

gcctaccagc tgcgtcagca gtcaggtgac ccttttgcga cagtttgcga caccacgtgg      240

ccgctgaggg tatatattct cgagtgagcg aaccaggagc tccattttga ccgcgaaatt      300

tgaacgagca gcagccatgc cggggttcta cgagattgtc ctgaaggtcc cgagtgacct      360

ggacgagcac ctgccgggca tttctaactc gtttgttaac tgggtggccg agaaggaatg      420

ggagctgccg ccggattctg acatggatcc gaatctgatt gagcaggcac ccctgaccgt      480

ggccgaaaag cttcagcgcg agttcctggt ggagtggcgc cgcgtgagta aggccccgga      540

ggccctcttt tttgtccagt tcgaaaaggg ggagacctac ttccacctgc acgtgctgat      600

tgagaccatc ggggtcaaat ccatggtggt cggccgctac gtgagccaga ttaaagagaa      660

gctggtgacc cgcatctacc gcggggtcga gccgcagctt ccgaactggt tcgcggtgac      720

caaaacgcga aatggcgccg ggggcgggaa caaggtggtg gacgactgct acatccccaa      780

ctacctgctc cccaagaccc agcccgagct ccagtgggcg tggactaaca tggaccagta      840

tttaagcgcc tgtttgaatc tcgcggagcg taaacggctg gtggcgcagc atctgacgca      900

cgtgtcgcag acgcaggagc agaacaaaga gaatcagaac cccaattctg acgcgccggt      960

catcaggtca aaaacctcag ccaggtacat ggagctggtc gggtggctgg tggaccgcgg     1020

gatcacgtca gaaaagcaat ggattcagga ggaccaggcc tcgtacatct ccttcaacgc     1080

cgcctccaac tcgcggtccc agatcaaggc cgcgctggac aatgcctcca agatcatgag     1140

cctgacaaag acggctccgg actacctggt gggcagcaac ccgccggagg acattaccaa     1200

aaatcggatc taccaaatcc tggagctgaa cgggtacgat ccgcagtacg cggcctccgt     1260

cttcctgggc tgggcgcaaa agaagttcgg gaagaggaac accatctggc tctttgggcc     1320

ggccacgacg ggtaaaacca acatcgcgga agccatcgcc cacgccgtgc ccttctacgg     1380

ctgcgtaaac tggaccaatg agaactttcc cttcaacgat tgcgtcgaca agatggtgat     1440

ctggtgggag gagggcaaga tgacggccaa ggtcgtggag agcgccaagg ccattctggg     1500

cggaagcaag gtgcgcgtgg accaaaagtg caagtcatcg gcccagatcg aacccactcc     1560

cgtgatcgtc acctccaaca ccaacatgtg cgccgtgatt gacgggaaca gcaccacctt     1620

cgagcatcag cagccgctgc aggaccggat gtttaaattt gaacttaccc gccgtttgga     1680

ccatgacttt gggaaggtca ccaaacagga agtaaaggac tttttccggt gggcttccga     1740

tcacgtgact gacgtggctc atgagttcta cgtcagaaag ggtggagcta agaaacgccc     1800

cgcctccaat gacgcggatg taagcgagcc aaaacggcag tgcacgtcac ttgcgcagcc     1860

gacaacgtca gacgcggaag caccggcgga ctacgcggac aggtaccaaa acaaatgttc     1920

tcgtcacgtg ggcatgaatc tgatgctttt tccctgtaaa acatgcgaga gaatgaatca     1980

aatttccaat gtctgtttta cgcatggtca aagagactgt ggggaatgct tccctggaat     2040

gtcagaatct caacccgttt ctgtcgtcaa aaagaagact tatcagaaac tgtgtccaat     2100

tcatcatatc ctgggaaggg cacccgagat tgcctgttcg gcctgcgatt tggccaatgt     2160

ggacttggat gactgtgttt ctgagcaata aatgacttaa accaggtatg gctgctgacg     2220

gttatcttcc agattggctc gaggacaacc tttctgaagg cattcgtgag tggtgggctc     2280

tgaaacctgg agtccctcaa cccaaagcga accaacaaca ccaggacaac cgtcggggtc     2340

ttgtgcttcc gggttacaaa tacctcggac ccggtaacgg actcgacaaa ggagagccgg     2400

tcaacgaggc ggacgcggca gccctcgaac acgacaaagc ttacgaccag cagctcaagg     2460

ccggtgacaa cccgtacctc aagtacaacc acgccgacgc cgagtttcag gagcgtcttc     2520

aagaagatac gtcttttggg ggcaaccttg gcagagcagt cttccaggcc aaaaagagga     2580

tccttgagcc tcttggtctg gttgaggaag cagctaaaac ggctcctgga aagaagaggc     2640

ctgtagatca gtctcctcag gaaccggact catcatctgg tgttggcaaa tcgggcaaac     2700

agcctgccag aaaaagacta aatttcggtc agactggcga ctcagagtca gtcccagacc     2760

ctcaacctct cggagaacca ccagcagccc ccacaagttt gggatctaat acaatggctt     2820

caggcggtgg cgcaccaatg gcagacaata acgagggtgc cgatggagtg ggtaattcct     2880

caggaaattg gcattgcgat tcccaatggc tgggcgacag agtcatcacc accagcacca     2940

gaacctgggc cctgcccact tacaacaacc atctctacaa gcaaatctcc agccaatcag     3000

gagcttcaaa cgacaaccac tactttggct acagcacccc ttgggggtat tttgacttta     3060

acagattcca ctgccacttc tcaccacgtg actggcagcg actcattaac aacaactggg     3120

gattccggcc caagaaactc agcttcaagc tcttcaacat ccaagttaaa gaggtcacgc     3180

agaacgatgg cacgacgact attgccaata accttaccag cacggttcaa gtgtttacgg     3240

actcggagta tcagctcccg tacgtgctcg ggtcggcgca ccaaggctgt ctcccgccgt     3300

ttccagcgga cgtcttcatg gtccctcagt atggatacct caccctgaac aacggaagtc     3360

aagcggtggg acgctcatcc ttttactgcc tggagtactt cccttcgcag atgctaagga     3420

ctggaaataa cttccaattc agctatacct tcgaggatgt accttttcac agcagctacg     3480

ctcacagcca gagtttggat cgcttgatga atcctcttat tgatcagtat ctgtactacc     3540

tgaacagaac gcaaggaaca acctctggaa caaccaacca atcacggctg ctttttagcc     3600

aggctgggcc tcagtctatg tctttgcagg ccagaaattg gctacctggg ccctgctacc     3660

ggcaacagag actttcaaag actgctaacg acaacaacaa cagtaacttt ccttggacag     3720

cggccagcaa atatcatctc aatggccgcg actcgctggt gaatccagga ccagctatgg     3780

ccagtcacaa ggacgatgaa gaaaaatttt tccctatgca cggcaatcta atatttggca     3840

aagaagggac aacggcaagt aacgcagaat tagataatgt aatgattacg gatgaagaag     3900

agattcgtac caccaatcct gtggcaacag agcagtatgg aactgtggca aataacttgc     3960

agagctcaaa tacagctccc acgactagaa ctgtcaatga tcagggggcc ttacctggca     4020

tggtgtggca agatcgtgac gtgtaccttc aaggacctat ctgggcaaag attcctcaca     4080

cggatggaca ctttcatcct tctcctctga tgggaggctt tggactgaaa catccgcctc     4140

ctcaaatcat gatcaaaaat actccggtac cggcaaatcc tccgacgact ttcagcccgg     4200

ccaagtttgc ttcatttatc actcagtact ccactggaca ggtcagcgtg gaaattgagt     4260

gggagctaca gaaagaaaac agcaaacgtt ggaatccaga gattcagtac acttccaact     4320

acaacaagtc tgttaatgtg gactttactg tagacactaa tggtgtttat agtgaacctc     4380

gccctattgg aacccggtat ctcacacgaa acttgtaatc ctggttaatc aataaaccgt     4440

ttaattcgtt tcagttgaac tttggctctt gtgcacttct tatcttatct tgtttccatg     4500

gctactgcgt agataagcag cggcctgcgg cgcttgcgct tcgcggttta caactgctgg     4560

ttaatattta actctcgcca tacctctagt gatggagttg gccactccct ctatgcgcac     4620

tcgctcgctc ggtggggccg gacgtgcaaa gcacgtccgt ctggcgacct ttggtcgcca     4680

ggccccaccg agcgagcgag tgcgcataga gggagtggcc aa                        4722


<210>  42
<211>  1800
<212>  DNA
<213>  Adeno-associated virus 4


<220>
<221>  modified_base
<222>  (342)..(342)
<223>  n = a, c, t, or g

<220>
<221>  misc_feature
<222>  (342)..(342)
<223>  n is a, c, g, or t

<400>  42
acggctcctg gaaagaagag accgttgatt gaatcccccc agcagcccga ctcctccacg       60

ggtatcggca aaaaaggcaa gcagccggct aaaaagaagc tcgttttcga agacgaaact      120

ggagcaggcg acggaccccc tgagggatca acttccggag ccatgtctga tgacagtgag      180

atgcgtgcag cagctggcgg agctgcagtc gagggsggac aaggtgccga tggagtgggt      240

aatgcctcgg gtgattggca ttgcgattcc acctggtctg agggccacgt cacgaccacc      300

agcaccagaa cctgggtctt gcccacctac aacaaccacc tntacaagcg actcggagag      360

agcctgcagt ccaacaccta caacggattc tccaccccct ggggatactt tgacttcaac      420

cgcttccact gccacttctc accacgtgac tggcagcgac tcatcaacaa caactggggc      480

atgcgaccca aagccatgcg ggtcaaaatc ttcaacatcc aggtcaagga ggtcacgacg      540

tcgaacggcg agacaacggt ggctaataac cttaccagca cggttcagat ctttgcggac      600

tcgtcgtacg aactgccgta cgtgatggat gcgggtcaag agggcagcct gcctcctttt      660

cccaacgacg tctttatggt gccccagtac ggctactgtg gactggtgac cggcaacact      720

tcgcagcaac agactgacag aaatgccttc tactgcctgg agtactttcc ttcgcagatg      780

ctgcggactg gcaacaactt tgaaattacg tacagttttg agaaggtgcc tttccactcg      840

atgtacgcgc acagccagag cctggaccgg ctgatgaacc ctctcatcga ccagtacctg      900

tggggactgc aatcgaccac caccggaacc accctgaatg ccgggactgc caccaccaac      960

tttaccaagc tgcggcctac caacttttcc aactttaaaa agaactggct gcccgggcct     1020

tcaatcaagc agcagggctt ctcaaagact gccaatcaaa actacaagat ccctgccacc     1080

gggtcagaca gtctcatcaa atacgagacg cacagcactc tggacggaag atggagtgcc     1140

ctgacccccg gacctccaat ggccacggct ggacctgcgg acagcaagtt cagcaacagc     1200

cagctcatct ttgcggggcc taaacagaac ggcaacacgg ccaccgtacc cgggactctg     1260

atcttcacct ctgaggagga gctggcagcc accaacgcca ccgatacgga catgtggggc     1320

aacctacctg gcggtgacca gagcaacagc aacctgccga ccgtggacag actgacagcc     1380

ttgggagccg tgcctggaat ggtctggcaa aacagagaca tttactacca gggtcccatt     1440

tgggccaaga ttcctcatac cgatggacac tttcacccct caccgctgat tggtgggttt     1500

gggctgaaac acccgcctcc tcaaattttt atcaagaaca ccccggtacc tgcgaatcct     1560

gcaacgacct tcagctctac tccggtaaac tccttcatta ctcagtacag cactggccag     1620

gtgtcggtgc agattgactg ggagatccag aaggagcggt ccaaacgctg gaaccccgag     1680

gtccagttta cctccaacta cggacagcaa aactctctgt tgtgggctcc cgatgcggct     1740

gggaaataca ctgagcctag ggctatcggt acccgctacc tcacccacca cctgtaataa     1800


<210>  43
<211>  2208
<212>  DNA
<213>  Adeno-associated virus 4


<220>
<221>  modified_base
<222>  (750)..(750)
<223>  n = a, c, t, or g

<220>
<221>  misc_feature
<222>  (750)..(750)
<223>  n is a, c, g, or t

<400>  43
atgactgacg gttaccttcc agattggcta gaggacaacc tctctgaagg cgttcgagag       60

tggtgggcgc tgcaacctgg agcccctaaa cccaaggcaa atcaacaaca tcaggacaac      120

gctcggggtc ttgtgcttcc gggttacaaa tacctcggac ccggcaacgg actcgacaag      180

ggggaacccg tcaacgcagc ggacgcggca gccctcgagc acgacaaggc ctacgaccag      240

cagctcaagg ccggtgacaa cccctacctc aagtacaacc acgccgacgc ggagttccag      300

cagcggcttc agggcgacac atcgtttggg ggcaacctcg gcagagcagt cttccaggcc      360

aaaaagaggg ttcttgaacc tcttggtctg gttgagcaag cgggtgagac ggctcctgga      420

aagaagagac cgttgattga atccccccag cagcccgact cctccacggg tatcggcaaa      480

aaaggcaagc agccggctaa aaagaagctc gttttcgaag acgaaactgg agcaggcgac      540

ggaccccctg agggatcaac ttccggagcc atgtctgatg acagtgagat gcgtgcagca      600

gctggcggag ctgcagtcga gggsggacaa ggtgccgatg gagtgggtaa tgcctcgggt      660

gattggcatt gcgattccac ctggtctgag ggccacgtca cgaccaccag caccagaacc      720

tgggtcttgc ccacctacaa caaccacctn tacaagcgac tcggagagag cctgcagtcc      780

aacacctaca acggattctc caccccctgg ggatactttg acttcaaccg cttccactgc      840

cacttctcac cacgtgactg gcagcgactc atcaacaaca actggggcat gcgacccaaa      900

gccatgcggg tcaaaatctt caacatccag gtcaaggagg tcacgacgtc gaacggcgag      960

acaacggtgg ctaataacct taccagcacg gttcagatct ttgcggactc gtcgtacgaa     1020

ctgccgtacg tgatggatgc gggtcaagag ggcagcctgc ctccttttcc caacgacgtc     1080

tttatggtgc cccagtacgg ctactgtgga ctggtgaccg gcaacacttc gcagcaacag     1140

actgacagaa atgccttcta ctgcctggag tactttcctt cgcagatgct gcggactggc     1200

aacaactttg aaattacgta cagttttgag aaggtgcctt tccactcgat gtacgcgcac     1260

agccagagcc tggaccggct gatgaaccct ctcatcgacc agtacctgtg gggactgcaa     1320

tcgaccacca ccggaaccac cctgaatgcc gggactgcca ccaccaactt taccaagctg     1380

cggcctacca acttttccaa ctttaaaaag aactggctgc ccgggccttc aatcaagcag     1440

cagggcttct caaagactgc caatcaaaac tacaagatcc ctgccaccgg gtcagacagt     1500

ctcatcaaat acgagacgca cagcactctg gacggaagat ggagtgccct gacccccgga     1560

cctccaatgg ccacggctgg acctgcggac agcaagttca gcaacagcca gctcatcttt     1620

gcggggccta aacagaacgg caacacggcc accgtacccg ggactctgat cttcacctct     1680

gaggaggagc tggcagccac caacgccacc gatacggaca tgtggggcaa cctacctggc     1740

ggtgaccaga gcaacagcaa cctgccgacc gtggacagac tgacagcctt gggagccgtg     1800

cctggaatgg tctggcaaaa cagagacatt tactaccagg gtcccatttg ggccaagatt     1860

cctcataccg atggacactt tcacccctca ccgctgattg gtgggtttgg gctgaaacac     1920

ccgcctcctc aaatttttat caagaacacc ccggtacctg cgaatcctgc aacgaccttc     1980

agctctactc cggtaaactc cttcattact cagtacagca ctggccaggt gtcggtgcag     2040

attgactggg agatccagaa ggagcggtcc aaacgctgga accccgaggt ccagtttacc     2100

tccaactacg gacagcaaaa ctctctgttg tgggctcccg atgcggctgg gaaatacact     2160

gagcctaggg ctatcggtac ccgctacctc acccaccacc tgtaataa                  2208


<210>  44
<211>  1872
<212>  DNA
<213>  Adeno-associated virus 4

<400>  44
atgccggggt tctacgagat cgtgctgaag gtgcccagcg acctggacga gcacctgccc       60

ggcatttctg actcttttgt gagctgggtg gccgagaagg aatgggagct gccgccggat      120

tctgacatgg acttgaatct gattgagcag gcacccctga ccgtggccga aaagctgcaa      180

cgcgagttcc tggtcgagtg gcgccgcgtg agtaaggccc cggaggccct cttctttgtc      240

cagttcgaga agggggacag ctacttccac ctgcacatcc tggtggagac cgtgggcgtc      300

aaatccatgg tggtgggccg ctacgtgagc cagattaaag agaagctggt gacccgcatc      360

taccgcgggg tcgagccgca gcttccgaac tggttcgcgg tgaccaagac gcgtaatggc      420

gccggaggcg ggaacaaggt ggtggacgac tgctacatcc ccaactacct gctccccaag      480

acccagcccg agctccagtg ggcgtggact aacatggacc agtatataag cgcctgtttg      540

aatctcgcgg agcgtaaacg gctggtggcg cagcatctga cgcacgtgtc gcagacgcag      600

gagcagaaca aggaaaacca gaaccccaat tctgacgcgc cggtcatcag gtcaaaaacc      660

tccgccaggt acatggagct ggtcgggtgg ctggtggacc gcgggatcac gtcagaaaag      720

caatggatcc aggaggacca ggcgtcctac atctccttca acgccgcctc caactcgcgg      780

tcacaaatca aggccgcgct ggacaatgcc tccaaaatca tgagcctgac aaagacggct      840

ccggactacc tggtgggcca gaacccgccg gaggacattt ccagcaaccg catctaccga      900

atcctcgaga tgaacgggta cgatccgcag tacgcggcct ccgtcttcct gggctgggcg      960

caaaagaagt tcgggaagag gaacaccatc tggctctttg ggccggccac gacgggtaaa     1020

accaacatcg cggaagccat cgcccacgcc gtgcccttct acggctgcgt gaactggacc     1080

aatgagaact ttccgttcaa cgattgcgtc gacaagatgg tgatctggtg ggaggagggc     1140

aagatgacgg ccaaggtcgt agagagcgcc aaggccatcc tgggcggaag caaggtgcgc     1200

gtggaccaaa agtgcaagtc atcggcccag atcgacccaa ctcccgtgat cgtcacctcc     1260

aacaccaaca tgtgcgcggt catcgacgga aactcgacca ccttcgagca ccaacaacca     1320

ctccaggacc ggatgttcaa gttcgagctc accaagcgcc tggagcacga ctttggcaag     1380

gtcaccaagc aggaagtcaa agactttttc cggtgggcgt cagatcacgt gaccgaggtg     1440

actcacgagt tttacgtcag aaagggtgga gctagaaaga ggcccgcccc caatgacgca     1500

gatataagtg agcccaagcg ggcctgtccg tcagttgcgc agccatcgac gtcagacgcg     1560

gaagctccgg tggactacgc ggacaggtac caaaacaaat gttctcgtca cgtgggtatg     1620

aatctgatgc tttttccctg ccggcaatgc gagagaatga atcagaatgt ggacatttgc     1680

ttcacgcacg gggtcatgga ctgtgccgag tgcttccccg tgtcagaatc tcaacccgtg     1740

tctgtcgtca gaaagcggac gtatcagaaa ctgtgtccga ttcatcacat catggggagg     1800

gcgcccgagg tggcctgctc ggcctgcgaa ctggccaatg tggacttgga tgactgtgac     1860

atggaacaat aa                                                         1872


<210>  45
<211>  1611
<212>  DNA
<213>  Adeno-associated virus 4

<400>  45
atgccggggt tctacgagat cgtgctgaag gtgcccagcg acctggacga gcacctgccc       60

ggcatttctg actcttttgt gagctgggtg gccgagaagg aatgggagct gccgccggat      120

tctgacatgg acttgaatct gattgagcag gcacccctga ccgtggccga aaagctgcaa      180

cgcgagttcc tggtcgagtg gcgccgcgtg agtaaggccc cggaggccct cttctttgtc      240

cagttcgaga agggggacag ctacttccac ctgcacatcc tggtggagac cgtgggcgtc      300

aaatccatgg tggtgggccg ctacgtgagc cagattaaag agaagctggt gacccgcatc      360

taccgcgggg tcgagccgca gcttccgaac tggttcgcgg tgaccaagac gcgtaatggc      420

gccggaggcg ggaacaaggt ggtggacgac tgctacatcc ccaactacct gctccccaag      480

acccagcccg agctccagtg ggcgtggact aacatggacc agtatataag cgcctgtttg      540

aatctcgcgg agcgtaaacg gctggtggcg cagcatctga cgcacgtgtc gcagacgcag      600

gagcagaaca aggaaaacca gaaccccaat tctgacgcgc cggtcatcag gtcaaaaacc      660

tccgccaggt acatggagct ggtcgggtgg ctggtggacc gcgggatcac gtcagaaaag      720

caatggatcc aggaggacca ggcgtcctac atctccttca acgccgcctc caactcgcgg      780

tcacaaatca aggccgcgct ggacaatgcc tccaaaatca tgagcctgac aaagacggct      840

ccggactacc tggtgggcca gaacccgccg gaggacattt ccagcaaccg catctaccga      900

atcctcgaga tgaacgggta cgatccgcag tacgcggcct ccgtcttcct gggctgggcg      960

caaaagaagt tcgggaagag gaacaccatc tggctctttg ggccggccac gacgggtaaa     1020

accaacatcg cggaagccat cgcccacgcc gtgcccttct acggctgcgt gaactggacc     1080

aatgagaact ttccgttcaa cgattgcgtc gacaagatgg tgatctggtg ggaggagggc     1140

aagatgacgg ccaaggtcgt agagagcgcc aaggccatcc tgggcggaag caaggtgcgc     1200

gtggaccaaa agtgcaagtc atcggcccag atcgacccaa ctcccgtgat cgtcacctcc     1260

aacaccaaca tgtgcgcggt catcgacgga aactcgacca ccttcgagca ccaacaacca     1320

ctccaggacc ggatgttcaa gttcgagctc accaagcgcc tggagcacga ctttggcaag     1380

gtcaccaagc aggaagtcaa agactttttc cggtgggcgt cagatcacgt gaccgaggtg     1440

actcacgagt tttacgtcag aaagggtgga gctagaaaga ggcccgcccc caatgacgca     1500

gatataagtg agcccaagcg ggcctgtccg tcagttgcgc agccatcgac gtcagacgcg     1560

gaagctccgg tggactacgc ggacagattg gctagaggac aacctctctg a              1611


<210>  46
<211>  1872
<212>  DNA
<213>  Adeno-associated virus 4

<400>  46
atgccggggt tctacgagat cgtgctgaag gtgcccagcg acctggacga gcacctgccc       60

ggcatttctg actcttttgt gagctgggtg gccgagaagg aatgggagct gccgccggat      120

tctgacatgg acttgaatct gattgagcag gcacccctga ccgtggccga aaagctgcaa      180

cgcgagttcc tggtcgagtg gcgccgcgtg agtaaggccc cggaggccct cttctttgtc      240

cagttcgaga agggggacag ctacttccac ctgcacatcc tggtggagac cgtgggcgtc      300

aaatccatgg tggtgggccg ctacgtgagc cagattaaag agaagctggt gacccgcatc      360

taccgcgggg tcgagccgca gcttccgaac tggttcgcgg tgaccaagac gcgtaatggc      420

gccggaggcg ggaacaaggt ggtggacgac tgctacatcc ccaactacct gctccccaag      480

acccagcccg agctccagtg ggcgtggact aacatggacc agtatataag cgcctgtttg      540

aatctcgcgg agcgtaaacg gctggtggcg cagcatctga cgcacgtgtc gcagacgcag      600

gagcagaaca aggaaaacca gaaccccaat tctgacgcgc cggtcatcag gtcaaaaacc      660

tccgccaggt acatggagct ggtcgggtgg ctggtggacc gcgggatcac gtcagaaaag      720

caatggatcc aggaggacca ggcgtcctac atctccttca acgccgcctc caactcgcgg      780

tcacaaatca aggccgcgct ggacaatgcc tccaaaatca tgagcctgac aaagacggct      840

ccggactacc tggtgggcca gaacccgccg gaggacattt ccagcaaccg catctaccga      900

atcctcgaga tgaacgggta cgatccgcag tacgcggcct ccgtcttcct gggctgggcg      960

caaaagaagt tcgggaagag gaacaccatc tggctctttg ggccggccac gacgggtaaa     1020

accaacatcg cggaagccat cgcccacgcc gtgcccttct acggctgcgt gaactggacc     1080

aatgagaact ttccgttcaa cgattgcgtc gacaagatgg tgatctggtg ggaggagggc     1140

aagatgacgg ccaaggtcgt agagagcgcc aaggccatcc tgggcggaag caaggtgcgc     1200

gtggaccaaa agtgcaagtc atcggcccag atcgacccaa ctcccgtgat cgtcacctcc     1260

aacaccaaca tgtgcgcggt catcgacgga aactcgacca ccttcgagca ccaacaacca     1320

ctccaggacc ggatgttcaa gttcgagctc accaagcgcc tggagcacga ctttggcaag     1380

gtcaccaagc aggaagtcaa agactttttc cggtgggcgt cagatcacgt gaccgaggtg     1440

actcacgagt tttacgtcag aaagggtgga gctagaaaga ggcccgcccc caatgacgca     1500

gatataagtg agcccaagcg ggcctgtccg tcagttgcgc agccatcgac gtcagacgcg     1560

gaagctccgg tggactacgc ggacaggtac caaaacaaat gttctcgtca cgtgggtatg     1620

aatctgatgc tttttccctg ccggcaatgc gagagaatga atcagaatgt ggacatttgc     1680

ttcacgcacg gggtcatgga ctgtgccgag tgcttccccg tgtcagaatc tcaacccgtg     1740

tctgtcgtca gaaagcggac gtatcagaaa ctgtgtccga ttcatcacat catggggagg     1800

gcgcccgagg tggcctgctc ggcctgcgaa ctggccaatg tggacttgga tgactgtgac     1860

atggaacaat aa                                                         1872


<210>  47
<211>  1617
<212>  DNA
<213>  Adeno-associated virus 4


<220>
<221>  modified_base
<222>  (162)..(162)
<223>  n = a, c, t, or g

<220>
<221>  misc_feature
<222>  (162)..(162)
<223>  n is a, c, g, or t

<400>  47
atgcgtgcag cagctggcgg agctgcagtc gagggsggac aaggtgccga tggagtgggt       60

aatgcctcgg gtgattggca ttgcgattcc acctggtctg agggccacgt cacgaccacc      120

agcaccagaa cctgggtctt gcccacctac aacaaccacc tntacaagcg actcggagag      180

agcctgcagt ccaacaccta caacggattc tccaccccct ggggatactt tgacttcaac      240

cgcttccact gccacttctc accacgtgac tggcagcgac tcatcaacaa caactggggc      300

atgcgaccca aagccatgcg ggtcaaaatc ttcaacatcc aggtcaagga ggtcacgacg      360

tcgaacggcg agacaacggt ggctaataac cttaccagca cggttcagat ctttgcggac      420

tcgtcgtacg aactgccgta cgtgatggat gcgggtcaag agggcagcct gcctcctttt      480

cccaacgacg tctttatggt gccccagtac ggctactgtg gactggtgac cggcaacact      540

tcgcagcaac agactgacag aaatgccttc tactgcctgg agtactttcc ttcgcagatg      600

ctgcggactg gcaacaactt tgaaattacg tacagttttg agaaggtgcc tttccactcg      660

atgtacgcgc acagccagag cctggaccgg ctgatgaacc ctctcatcga ccagtacctg      720

tggggactgc aatcgaccac caccggaacc accctgaatg ccgggactgc caccaccaac      780

tttaccaagc tgcggcctac caacttttcc aactttaaaa agaactggct gcccgggcct      840

tcaatcaagc agcagggctt ctcaaagact gccaatcaaa actacaagat ccctgccacc      900

gggtcagaca gtctcatcaa atacgagacg cacagcactc tggacggaag atggagtgcc      960

ctgacccccg gacctccaat ggccacggct ggacctgcgg acagcaagtt cagcaacagc     1020

cagctcatct ttgcggggcc taaacagaac ggcaacacgg ccaccgtacc cgggactctg     1080

atcttcacct ctgaggagga gctggcagcc accaacgcca ccgatacgga catgtggggc     1140

aacctacctg gcggtgacca gagcaacagc aacctgccga ccgtggacag actgacagcc     1200

ttgggagccg tgcctggaat ggtctggcaa aacagagaca tttactacca gggtcccatt     1260

tgggccaaga ttcctcatac cgatggacac tttcacccct caccgctgat tggtgggttt     1320

gggctgaaac acccgcctcc tcaaattttt atcaagaaca ccccggtacc tgcgaatcct     1380

gcaacgacct tcagctctac tccggtaaac tccttcatta ctcagtacag cactggccag     1440

gtgtcggtgc agattgactg ggagatccag aaggagcggt ccaaacgctg gaaccccgag     1500

gtccagttta cctccaacta cggacagcaa aactctctgt tgtgggctcc cgatgcggct     1560

gggaaataca ctgagcctag ggctatcggt acccgctacc tcacccacca cctgtaa        1617


<210>  48
<211>  939
<212>  DNA
<213>  Adeno-associated virus 4

<400>  48
atggagctgg tcgggtggct ggtggaccgc gggatcacgt cagaaaagca atggatccag       60

gaggaccagg cgtcctacat ctccttcaac gccgcctcca actcgcggtc acaaatcaag      120

gccgcgctgg acaatgcctc caaaatcatg agcctgacaa agacggctcc ggactacctg      180

gtgggccaga acccgccgga ggacatttcc agcaaccgca tctaccgaat cctcgagatg      240

aacgggtacg atccgcagta cgcggcctcc gtcttcctgg gctgggcgca aaagaagttc      300

gggaagagga acaccatctg gctctttggg ccggccacga cgggtaaaac caacatcgcg      360

gaagccatcg cccacgccgt gcccttctac ggctgcgtga actggaccaa tgagaacttt      420

ccgttcaacg attgcgtcga caagatggtg atctggtggg aggagggcaa gatgacggcc      480

aaggtcgtag agagcgccaa ggccatcctg ggcggaagca aggtgcgcgt ggaccaaaag      540

tgcaagtcat cggcccagat cgacccaact cccgtgatcg tcacctccaa caccaacatg      600

tgcgcggtca tcgacggaaa ctcgaccacc ttcgagcacc aacaaccact ccaggaccgg      660

atgttcaagt tcgagctcac caagcgcctg gagcacgact ttggcaaggt caccaagcag      720

gaagtcaaag actttttccg gtgggcgtca gatcacgtga ccgaggtgac tcacgagttt      780

tacgtcagaa agggtggagc tagaaagagg cccgccccca atgacgcaga tataagtgag      840

cccaagcggg cctgtccgtc agttgcgcag ccatcgacgt cagacgcgga agctccggtg      900

gactacgcgg acagattggc tagaggacaa cctctctga                             939


<210>  49
<211>  1197
<212>  DNA
<213>  Adeno-associated virus 4

<400>  49
atggagctgg tcgggtggct ggtggaccgc gggatcacgt cagaaaagca atggatccag       60

gaggaccagg cgtcctacat ctccttcaac gccgcctcca actcgcggtc acaaatcaag      120

gccgcgctgg acaatgcctc caaaatcatg agcctgacaa agacggctcc ggactacctg      180

gtgggccaga acccgccgga ggacatttcc agcaaccgca tctaccgaat cctcgagatg      240

aacgggtacg atccgcagta cgcggcctcc gtcttcctgg gctgggcgca aaagaagttc      300

gggaagagga acaccatctg gctctttggg ccggccacga cgggtaaaac caacatcgcg      360

gaagccatcg cccacgccgt gcccttctac ggctgcgtga actggaccaa tgagaacttt      420

ccgttcaacg attgcgtcga caagatggtg atctggtggg aggagggcaa gatgacggcc      480

aaggtcgtag agagcgccaa ggccatcctg ggcggaagca aggtgcgcgt ggaccaaaag      540

tgcaagtcat cggcccagat cgacccaact cccgtgatcg tcacctccaa caccaacatg      600

tgcgcggtca tcgacggaaa ctcgaccacc ttcgagcacc aacaaccact ccaggaccgg      660

atgttcaagt tcgagctcac caagcgcctg gagcacgact ttggcaaggt caccaagcag      720

gaagtcaaag actttttccg gtgggcgtca gatcacgtga ccgaggtgac tcacgagttt      780

tacgtcagaa agggtggagc tagaaagagg cccgccccca atgacgcaga tataagtgag      840

cccaagcggg cctgtccgtc agttgcgcag ccatcgacgt cagacgcgga agctccggtg      900

gactacgcgg acaggtacca aaacaaatgt tctcgtcacg tgggtatgaa tctgatgctt      960

tttccctgcc ggcaatgcga gagaatgaat cagaatgtgg acatttgctt cacgcacggg     1020

gtcatggact gtgccgagtg cttccccgtg tcagaatctc aacccgtgtc tgtcgtcaga     1080

aagcggacgt atcagaaact gtgtccgatt catcacatca tggggagggc gcccgaggtg     1140

gcctgctcgg cctgcgaact ggccaatgtg gacttggatg actgtgacat ggaacaa        1197


<210>  50
<211>  245
<212>  DNA
<213>  Adeno-associated virus 4

<400>  50
ctccatcatc taggtttgcc cactgacgtc aatgtgacgt cctagggtta gggaggtccc       60

tgtattagca gtcacgtgag tgtcgtattt cgcggagcgt agcggagcgc ataccaagct      120

gccacgtcac agccacgtgg tccgtttgcg acagtttgcg acaccatgtg gtcaggaggg      180

tatataaccg cgagtgagcc agcgaggagc tccattttgc ccgcgaattt tgaacgagca      240

gcagc                                                                  245


<210>  51
<211>  313
<212>  PRT
<213>  Adeno-associated virus 4


<220>
<221>  MOD_RES
<222>  (313)..(313)
<223>  Xaa = any amino acid

<400>  51

Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
1               5                   10                  15      


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
            20                  25                  30          


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Ser Lys 
        35                  40                  45              


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Asn 
    50                  55                  60                  


Pro Pro Glu Asp Ile Ser Ser Asn Arg Ile Tyr Arg Ile Leu Glu Met 
65                  70                  75                  80  


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
                85                  90                  95      


Gln Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
            100                 105                 110         


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
        115                 120                 125             


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
    130                 135                 140                 


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
145                 150                 155                 160 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
                165                 170                 175     


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
            180                 185                 190         


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
        195                 200                 205             


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
    210                 215                 220                 


Glu Leu Thr Lys Arg Leu Glu His Asp Phe Gly Lys Val Thr Lys Gln 
225                 230                 235                 240 


Glu Val Lys Asp Phe Phe Arg Trp Ala Ser Asp His Val Thr Glu Val 
                245                 250                 255     


Thr His Glu Phe Tyr Val Arg Lys Gly Gly Ala Arg Lys Arg Pro Ala 
            260                 265                 270         


Pro Asn Asp Ala Asp Ile Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 
        275                 280                 285             


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Pro Val Asp Tyr Ala Asp 
    290                 295                 300                 


Arg Leu Ala Arg Gly Gln Pro Leu Xaa 
305                 310             


<210>  52
<211>  399
<212>  PRT
<213>  Adeno-associated virus 4

<400>  52

Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
1               5                   10                  15      


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
            20                  25                  30          


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Ser Lys 
        35                  40                  45              


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Asn 
    50                  55                  60                  


Pro Pro Glu Asp Ile Ser Ser Asn Arg Ile Tyr Arg Ile Leu Glu Met 
65                  70                  75                  80  


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
                85                  90                  95      


Gln Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
            100                 105                 110         


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
        115                 120                 125             


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
    130                 135                 140                 


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
145                 150                 155                 160 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
                165                 170                 175     


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
            180                 185                 190         


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
        195                 200                 205             


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
    210                 215                 220                 


Glu Leu Thr Lys Arg Leu Glu His Asp Phe Gly Lys Val Thr Lys Gln 
225                 230                 235                 240 


Glu Val Lys Asp Phe Phe Arg Trp Ala Ser Asp His Val Thr Glu Val 
                245                 250                 255     


Thr His Glu Phe Tyr Val Arg Lys Gly Gly Ala Arg Lys Arg Pro Ala 
            260                 265                 270         


Pro Asn Asp Ala Asp Ile Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 
        275                 280                 285             


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Pro Val Asp Tyr Ala Asp 
    290                 295                 300                 


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
305                 310                 315                 320 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Val Asp Ile Cys 
                325                 330                 335     


Phe Thr His Gly Val Met Asp Cys Ala Glu Cys Phe Pro Val Ser Glu 
            340                 345                 350         


Ser Gln Pro Val Ser Val Val Arg Lys Arg Thr Tyr Gln Lys Leu Cys 
        355                 360                 365             


Pro Ile His His Ile Met Gly Arg Ala Pro Glu Val Ala Cys Ser Ala 
    370                 375                 380                 


Cys Glu Leu Ala Asn Val Asp Leu Asp Asp Cys Asp Met Glu Gln 
385                 390                 395                 


<210>  53
<211>  623
<212>  PRT
<213>  Adeno-associated virus 4

<400>  53

Met Pro Gly Phe Tyr Glu Ile Val Leu Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Ser Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Glu Phe Leu 
    50                  55                  60                  


Val Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Asp Ser Tyr Phe His Leu His Ile Leu Val Glu 
                85                  90                  95      


Thr Val Gly Val Lys Ser Met Val Val Gly Arg Tyr Val Ser Gln Ile 
            100                 105                 110         


Lys Glu Lys Leu Val Thr Arg Ile Tyr Arg Gly Val Glu Pro Gln Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Asp Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Asp Gln Tyr Ile 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Ser Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Asn 
        275                 280                 285             


Pro Pro Glu Asp Ile Ser Ser Asn Arg Ile Tyr Arg Ile Leu Glu Met 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Gln Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Lys Arg Leu Glu His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Ser Asp His Val Thr Glu Val 
465                 470                 475                 480 


Thr His Glu Phe Tyr Val Arg Lys Gly Gly Ala Arg Lys Arg Pro Ala 
                485                 490                 495     


Pro Asn Asp Ala Asp Ile Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Pro Val Asp Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Val Asp Ile Cys 
545                 550                 555                 560 


Phe Thr His Gly Val Met Asp Cys Ala Glu Cys Phe Pro Val Ser Glu 
                565                 570                 575     


Ser Gln Pro Val Ser Val Val Arg Lys Arg Thr Tyr Gln Lys Leu Cys 
            580                 585                 590         


Pro Ile His His Ile Met Gly Arg Ala Pro Glu Val Ala Cys Ser Ala 
        595                 600                 605             


Cys Glu Leu Ala Asn Val Asp Leu Asp Asp Cys Asp Met Glu Gln 
    610                 615                 620             


<210>  54
<211>  537
<212>  PRT
<213>  Adeno-associated virus 4


<220>
<221>  MOD_RES
<222>  (537)..(537)
<223>  Xaa = any amino acid

<400>  54

Met Pro Gly Phe Tyr Glu Ile Val Leu Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Ser Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Glu Phe Leu 
    50                  55                  60                  


Val Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Asp Ser Tyr Phe His Leu His Ile Leu Val Glu 
                85                  90                  95      


Thr Val Gly Val Lys Ser Met Val Val Gly Arg Tyr Val Ser Gln Ile 
            100                 105                 110         


Lys Glu Lys Leu Val Thr Arg Ile Tyr Arg Gly Val Glu Pro Gln Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Asp Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Asp Gln Tyr Ile 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Ser Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Asn 
        275                 280                 285             


Pro Pro Glu Asp Ile Ser Ser Asn Arg Ile Tyr Arg Ile Leu Glu Met 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Gln Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Lys Arg Leu Glu His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Ser Asp His Val Thr Glu Val 
465                 470                 475                 480 


Thr His Glu Phe Tyr Val Arg Lys Gly Gly Ala Arg Lys Arg Pro Ala 
                485                 490                 495     


Pro Asn Asp Ala Asp Ile Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Pro Val Asp Tyr Ala Asp 
        515                 520                 525             


Arg Leu Ala Arg Gly Gln Pro Leu Xaa 
    530                 535         


<210>  55
<211>  623
<212>  PRT
<213>  Adeno-associated virus 4

<400>  55

Met Pro Gly Phe Tyr Glu Ile Val Leu Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Ser Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Glu Phe Leu 
    50                  55                  60                  


Val Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Asp Ser Tyr Phe His Leu His Ile Leu Val Glu 
                85                  90                  95      


Thr Val Gly Val Lys Ser Met Val Val Gly Arg Tyr Val Ser Gln Ile 
            100                 105                 110         


Lys Glu Lys Leu Val Thr Arg Ile Tyr Arg Gly Val Glu Pro Gln Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Asp Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Asp Gln Tyr Ile 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Ser Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Asn 
        275                 280                 285             


Pro Pro Glu Asp Ile Ser Ser Asn Arg Ile Tyr Arg Ile Leu Glu Met 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Gln Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Lys Arg Leu Glu His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Ser Asp His Val Thr Glu Val 
465                 470                 475                 480 


Thr His Glu Phe Tyr Val Arg Lys Gly Gly Ala Arg Lys Arg Pro Ala 
                485                 490                 495     


Pro Asn Asp Ala Asp Ile Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Pro Val Asp Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Val Asp Ile Cys 
545                 550                 555                 560 


Phe Thr His Gly Val Met Asp Cys Ala Glu Cys Phe Pro Val Ser Glu 
                565                 570                 575     


Ser Gln Pro Val Ser Val Val Arg Lys Arg Thr Tyr Gln Lys Leu Cys 
            580                 585                 590         


Pro Ile His His Ile Met Gly Arg Ala Pro Glu Val Ala Cys Ser Ala 
        595                 600                 605             


Cys Glu Leu Ala Asn Val Asp Leu Asp Asp Cys Asp Met Glu Gln 
    610                 615                 620             


<210>  56
<211>  544
<212>  PRT
<213>  Adeno-associated virus 4

<400>  56

Met Ser Asp Asp Ser Glu Met Arg Ala Ala Ala Gly Gly Ala Ala Val 
1               5                   10                  15      


Glu Gly Gly Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp 
            20                  25                  30          


His Cys Asp Ser Thr Trp Ser Glu Gly His Val Thr Thr Thr Ser Thr 
        35                  40                  45              


Arg Thr Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Arg Leu 
    50                  55                  60                  


Gly Glu Ser Leu Gln Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp 
65                  70                  75                  80  


Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp 
                85                  90                  95      


Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Met Arg Pro Lys Ala Met 
            100                 105                 110         


Arg Val Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn 
        115                 120                 125             


Gly Glu Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe 
    130                 135                 140                 


Ala Asp Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu 
145                 150                 155                 160 


Gly Ser Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr 
                165                 170                 175     


Gly Tyr Cys Gly Leu Val Thr Gly Asn Thr Ser Gln Gln Gln Thr Asp 
            180                 185                 190         


Arg Asn Ala Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
        195                 200                 205             


Thr Gly Asn Asn Phe Glu Ile Thr Tyr Ser Phe Glu Lys Val Pro Phe 
    210                 215                 220                 


His Ser Met Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
225                 230                 235                 240 


Leu Ile Asp Gln Tyr Leu Trp Gly Leu Gln Ser Thr Thr Thr Gly Thr 
                245                 250                 255     


Thr Leu Asn Ala Gly Thr Ala Thr Thr Asn Phe Thr Lys Leu Arg Pro 
            260                 265                 270         


Thr Asn Phe Ser Asn Phe Lys Lys Asn Trp Leu Pro Gly Pro Ser Ile 
        275                 280                 285             


Lys Gln Gln Gly Phe Ser Lys Thr Ala Asn Gln Asn Tyr Lys Ile Pro 
    290                 295                 300                 


Ala Thr Gly Ser Asp Ser Leu Ile Lys Tyr Glu Thr His Ser Thr Leu 
305                 310                 315                 320 


Asp Gly Arg Trp Ser Ala Leu Thr Pro Gly Pro Pro Met Ala Thr Ala 
                325                 330                 335     


Gly Pro Ala Asp Ser Lys Phe Ser Asn Ser Gln Leu Ile Phe Ala Gly 
            340                 345                 350         


Pro Lys Gln Asn Gly Asn Thr Ala Thr Val Pro Gly Thr Leu Ile Phe 
        355                 360                 365             


Thr Ser Glu Glu Glu Leu Ala Ala Thr Asn Ala Thr Asp Thr Asp Met 
    370                 375                 380                 


Trp Gly Asn Leu Pro Gly Gly Asp Gln Ser Asn Ser Asn Leu Pro Thr 
385                 390                 395                 400 


Val Asp Arg Leu Thr Ala Leu Gly Ala Val Pro Gly Met Val Trp Gln 
                405                 410                 415     


Asn Arg Asp Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
            420                 425                 430         


Thr Asp Gly His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu 
        435                 440                 445             


Lys His Pro Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala 
    450                 455                 460                 


Asn Pro Ala Thr Thr Phe Ser Ser Thr Pro Val Asn Ser Phe Ile Thr 
465                 470                 475                 480 


Gln Tyr Ser Thr Gly Gln Val Ser Val Gln Ile Asp Trp Glu Ile Gln 
                485                 490                 495     


Lys Glu Arg Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn 
            500                 505                 510         


Tyr Gly Gln Gln Asn Ser Leu Leu Trp Ala Pro Asp Ala Ala Gly Lys 
        515                 520                 525             


Tyr Thr Glu Pro Arg Ala Ile Gly Thr Arg Tyr Leu Thr His His Leu 
    530                 535                 540                 


<210>  57
<211>  734
<212>  PRT
<213>  Adeno-associated virus 4

<400>  57

Met Thr Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser Glu 
1               5                   10                  15      


Gly Val Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro Lys 
            20                  25                  30          


Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro Val 
    50                  55                  60                  


Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Gln 
65                  70                  75                  80  


Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Gln Arg Leu Gln Gly Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Gln Ala Gly Glu Thr Ala Pro Gly Lys Lys Arg Pro 
    130                 135                 140                 


Leu Ile Glu Ser Pro Gln Gln Pro Asp Ser Ser Thr Gly Ile Gly Lys 
145                 150                 155                 160 


Lys Gly Lys Gln Pro Ala Lys Lys Lys Leu Val Phe Glu Asp Glu Thr 
                165                 170                 175     


Gly Ala Gly Asp Gly Pro Pro Glu Gly Ser Thr Ser Gly Ala Met Ser 
            180                 185                 190         


Asp Asp Ser Glu Met Arg Ala Ala Ala Gly Gly Ala Ala Val Glu Gly 
        195                 200                 205             


Gly Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys 
    210                 215                 220                 


Asp Ser Thr Trp Ser Glu Gly His Val Thr Thr Thr Ser Thr Arg Thr 
225                 230                 235                 240 


Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Arg Leu Gly Glu 
                245                 250                 255     


Ser Leu Gln Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Asn Trp Gly Met Arg Pro Lys Ala Met Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu 
305                 310                 315                 320 


Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp 
                325                 330                 335     


Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser 
            340                 345                 350         


Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Cys Gly Leu Val Thr Gly Asn Thr Ser Gln Gln Gln Thr Asp Arg Asn 
    370                 375                 380                 


Ala Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly 
385                 390                 395                 400 


Asn Asn Phe Glu Ile Thr Tyr Ser Phe Glu Lys Val Pro Phe His Ser 
                405                 410                 415     


Met Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile 
            420                 425                 430         


Asp Gln Tyr Leu Trp Gly Leu Gln Ser Thr Thr Thr Gly Thr Thr Leu 
        435                 440                 445             


Asn Ala Gly Thr Ala Thr Thr Asn Phe Thr Lys Leu Arg Pro Thr Asn 
    450                 455                 460                 


Phe Ser Asn Phe Lys Lys Asn Trp Leu Pro Gly Pro Ser Ile Lys Gln 
465                 470                 475                 480 


Gln Gly Phe Ser Lys Thr Ala Asn Gln Asn Tyr Lys Ile Pro Ala Thr 
                485                 490                 495     


Gly Ser Asp Ser Leu Ile Lys Tyr Glu Thr His Ser Thr Leu Asp Gly 
            500                 505                 510         


Arg Trp Ser Ala Leu Thr Pro Gly Pro Pro Met Ala Thr Ala Gly Pro 
        515                 520                 525             


Ala Asp Ser Lys Phe Ser Asn Ser Gln Leu Ile Phe Ala Gly Pro Lys 
    530                 535                 540                 


Gln Asn Gly Asn Thr Ala Thr Val Pro Gly Thr Leu Ile Phe Thr Ser 
545                 550                 555                 560 


Glu Glu Glu Leu Ala Ala Thr Asn Ala Thr Asp Thr Asp Met Trp Gly 
                565                 570                 575     


Asn Leu Pro Gly Gly Asp Gln Ser Asn Ser Asn Leu Pro Thr Val Asp 
            580                 585                 590         


Arg Leu Thr Ala Leu Gly Ala Val Pro Gly Met Val Trp Gln Asn Arg 
        595                 600                 605             


Asp Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Ala Thr Thr Phe Ser Ser Thr Pro Val Asn Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Gln Ile Asp Trp Glu Ile Gln Lys Glu 
        675                 680                 685             


Arg Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly 
    690                 695                 700                 


Gln Gln Asn Ser Leu Leu Trp Ala Pro Asp Ala Ala Gly Lys Tyr Thr 
705                 710                 715                 720 


Glu Pro Arg Ala Ile Gly Thr Arg Tyr Leu Thr His His Leu 
                725                 730                 


<210>  58
<211>  598
<212>  PRT
<213>  Adeno-associated virus 4

<400>  58

Thr Ala Pro Gly Lys Lys Arg Pro Leu Ile Glu Ser Pro Gln Gln Pro 
1               5                   10                  15      


Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Lys Gln Pro Ala Lys Lys 
            20                  25                  30          


Lys Leu Val Phe Glu Asp Glu Thr Gly Ala Gly Asp Gly Pro Pro Glu 
        35                  40                  45              


Gly Ser Thr Ser Gly Ala Met Ser Asp Asp Ser Glu Met Arg Ala Ala 
    50                  55                  60                  


Ala Gly Gly Ala Ala Val Glu Gly Gly Gln Gly Ala Asp Gly Val Gly 
65                  70                  75                  80  


Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp Ser Glu Gly His 
                85                  90                  95      


Val Thr Thr Thr Ser Thr Arg Thr Trp Val Leu Pro Thr Tyr Asn Asn 
            100                 105                 110         


His Leu Tyr Lys Arg Leu Gly Glu Ser Leu Gln Ser Asn Thr Tyr Asn 
        115                 120                 125             


Gly Phe Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys 
    130                 135                 140                 


His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly 
145                 150                 155                 160 


Met Arg Pro Lys Ala Met Arg Val Lys Ile Phe Asn Ile Gln Val Lys 
                165                 170                 175     


Glu Val Thr Thr Ser Asn Gly Glu Thr Thr Val Ala Asn Asn Leu Thr 
            180                 185                 190         


Ser Thr Val Gln Ile Phe Ala Asp Ser Ser Tyr Glu Leu Pro Tyr Val 
        195                 200                 205             


Met Asp Ala Gly Gln Glu Gly Ser Leu Pro Pro Phe Pro Asn Asp Val 
    210                 215                 220                 


Phe Met Val Pro Gln Tyr Gly Tyr Cys Gly Leu Val Thr Gly Asn Thr 
225                 230                 235                 240 


Ser Gln Gln Gln Thr Asp Arg Asn Ala Phe Tyr Cys Leu Glu Tyr Phe 
                245                 250                 255     


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Ile Thr Tyr Ser 
            260                 265                 270         


Phe Glu Lys Val Pro Phe His Ser Met Tyr Ala His Ser Gln Ser Leu 
        275                 280                 285             


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Trp Gly Leu Gln 
    290                 295                 300                 


Ser Thr Thr Thr Gly Thr Thr Leu Asn Ala Gly Thr Ala Thr Thr Asn 
305                 310                 315                 320 


Phe Thr Lys Leu Arg Pro Thr Asn Phe Ser Asn Phe Lys Lys Asn Trp 
                325                 330                 335     


Leu Pro Gly Pro Ser Ile Lys Gln Gln Gly Phe Ser Lys Thr Ala Asn 
            340                 345                 350         


Gln Asn Tyr Lys Ile Pro Ala Thr Gly Ser Asp Ser Leu Ile Lys Tyr 
        355                 360                 365             


Glu Thr His Ser Thr Leu Asp Gly Arg Trp Ser Ala Leu Thr Pro Gly 
    370                 375                 380                 


Pro Pro Met Ala Thr Ala Gly Pro Ala Asp Ser Lys Phe Ser Asn Ser 
385                 390                 395                 400 


Gln Leu Ile Phe Ala Gly Pro Lys Gln Asn Gly Asn Thr Ala Thr Val 
                405                 410                 415     


Pro Gly Thr Leu Ile Phe Thr Ser Glu Glu Glu Leu Ala Ala Thr Asn 
            420                 425                 430         


Ala Thr Asp Thr Asp Met Trp Gly Asn Leu Pro Gly Gly Asp Gln Ser 
        435                 440                 445             


Asn Ser Asn Leu Pro Thr Val Asp Arg Leu Thr Ala Leu Gly Ala Val 
    450                 455                 460                 


Pro Gly Met Val Trp Gln Asn Arg Asp Ile Tyr Tyr Gln Gly Pro Ile 
465                 470                 475                 480 


Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu 
                485                 490                 495     


Ile Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Phe Ile Lys 
            500                 505                 510         


Asn Thr Pro Val Pro Ala Asn Pro Ala Thr Thr Phe Ser Ser Thr Pro 
        515                 520                 525             


Val Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Gln 
    530                 535                 540                 


Ile Asp Trp Glu Ile Gln Lys Glu Arg Ser Lys Arg Trp Asn Pro Glu 
545                 550                 555                 560 


Val Gln Phe Thr Ser Asn Tyr Gly Gln Gln Asn Ser Leu Leu Trp Ala 
                565                 570                 575     


Pro Asp Ala Ala Gly Lys Tyr Thr Glu Pro Arg Ala Ile Gly Thr Arg 
            580                 585                 590         


Tyr Leu Thr His His Leu 
        595             


<210>  59
<211>  129
<212>  DNA
<213>  Adeno-associated virus 4

<400>  59
ttggccactc cctctatgcg cgctcgctca ctcactcggc cctgcggcca gaggccggca       60

gtctggagac ctttggtgtc cagggcaggg ccgagtgagt gagcgagcgc gcatagaggg      120

agtggccaa                                                              129


<210>  60
<211>  125
<212>  DNA
<213>  Adeno-associated virus 4

<400>  60
ttggccactc cctctatgcg cgctcgctca ctcactcggc cctggagacc aaaggtctcc       60

agactgccgg cctctggccg gcagggccga gtgagtgagc gagcgcgcat agagggagtg      120

gccaa                                                                  125


<210>  61
<211>  4768
<212>  DNA
<213>  Adeno-associated virus 4


<220>
<221>  modified_base
<222>  (3009)..(3009)
<223>  n = a, c, t, or g

<220>
<221>  misc_feature
<222>  (3009)..(3009)
<223>  n is a, c, g, or t

<400>  61
ttggccactc cctctatgcg cgctcgctca ctcactcggc cctggagacc aaaggtctcc       60

agactgccgg cctctggccg gcagggccga gtgagtgagc gagcgcgcat agagggagtg      120

gccaactcca tcatctaggt ttgcccactg acgtcaatgt gacgtcctag ggttagggag      180

gtccctgtat tagcagtcac gtgagtgtcg tatttcgcgg agcgtagcgg agcgcatacc      240

aagctgccac gtcacagcca cgtggtccgt ttgcgacagt ttgcgacacc atgtggtcag      300

gagggtatat aaccgcgagt gagccagcga ggagctccat tttgcccgcg aattttgaac      360

gagcagcagc catgccgggg ttctacgaga tcgtgctgaa ggtgcccagc gacctggacg      420

agcacctgcc cggcatttct gactcttttg tgagctgggt ggccgagaag gaatgggagc      480

tgccgccgga ttctgacatg gacttgaatc tgattgagca ggcacccctg accgtggccg      540

aaaagctgca acgcgagttc ctggtcgagt ggcgccgcgt gagtaaggcc ccggaggccc      600

tcttctttgt ccagttcgag aagggggaca gctacttcca cctgcacatc ctggtggaga      660

ccgtgggcgt caaatccatg gtggtgggcc gctacgtgag ccagattaaa gagaagctgg      720

tgacccgcat ctaccgcggg gtcgagccgc agcttccgaa ctggttcgcg gtgaccaaga      780

cgcgtaatgg cgccggaggc gggaacaagg tggtggacga ctgctacatc cccaactacc      840

tgctccccaa gacccagccc gagctccagt gggcgtggac taacatggac cagtatataa      900

gcgcctgttt gaatctcgcg gagcgtaaac ggctggtggc gcagcatctg acgcacgtgt      960

cgcagacgca ggagcagaac aaggaaaacc agaaccccaa ttctgacgcg ccggtcatca     1020

ggtcaaaaac ctccgccagg tacatggagc tggtcgggtg gctggtggac cgcgggatca     1080

cgtcagaaaa gcaatggatc caggaggacc aggcgtccta catctccttc aacgccgcct     1140

ccaactcgcg gtcacaaatc aaggccgcgc tggacaatgc ctccaaaatc atgagcctga     1200

caaagacggc tccggactac ctggtgggcc agaacccgcc ggaggacatt tccagcaacc     1260

gcatctaccg aatcctcgag atgaacgggt acgatccgca gtacgcggcc tccgtcttcc     1320

tgggctgggc gcaaaagaag ttcgggaaga ggaacaccat ctggctcttt gggccggcca     1380

cgacgggtaa aaccaacatc gcggaagcca tcgcccacgc cgtgcccttc tacggctgcg     1440

tgaactggac caatgagaac tttccgttca acgattgcgt cgacaagatg gtgatctggt     1500

gggaggaggg caagatgacg gccaaggtcg tagagagcgc caaggccatc ctgggcggaa     1560

gcaaggtgcg cgtggaccaa aagtgcaagt catcggccca gatcgaccca actcccgtga     1620

tcgtcacctc caacaccaac atgtgcgcgg tcatcgacgg aaactcgacc accttcgagc     1680

accaacaacc actccaggac cggatgttca agttcgagct caccaagcgc ctggagcacg     1740

actttggcaa ggtcaccaag caggaagtca aagacttttt ccggtgggcg tcagatcacg     1800

tgaccgaggt gactcacgag ttttacgtca gaaagggtgg agctagaaag aggcccgccc     1860

ccaatgacgc agatataagt gagcccaagc gggcctgtcc gtcagttgcg cagccatcga     1920

cgtcagacgc ggaagctccg gtggactacg cggacaggta ccaaaacaaa tgttctcgtc     1980

acgtgggtat gaatctgatg ctttttccct gccggcaatg cgagagaatg aatcagaatg     2040

tggacatttg cttcacgcac ggggtcatgg actgtgccga gtgcttcccc gtgtcagaat     2100

ctcaacccgt gtctgtcgtc agaaagcgga cgtatcagaa actgtgtccg attcatcaca     2160

tcatggggag ggcgcccgag gtggcctgct cggcctgcga actggccaat gtggacttgg     2220

atgactgtga catggaacaa taaatgactc aaaccagata tgactgacgg ttaccttcca     2280

gattggctag aggacaacct ctctgaaggc gttcgagagt ggtgggcgct gcaacctgga     2340

gcccctaaac ccaaggcaaa tcaacaacat caggacaacg ctcggggtct tgtgcttccg     2400

ggttacaaat acctcggacc cggcaacgga ctcgacaagg gggaacccgt caacgcagcg     2460

gacgcggcag ccctcgagca cgacaaggcc tacgaccagc agctcaaggc cggtgacaac     2520

ccctacctca agtacaacca cgccgacgcg gagttccagc agcggcttca gggcgacaca     2580

ccgtttgggg gcaacctcgg cagagcagtc ttccaggcca aaaagagggt tcttgaacct     2640

cttggtctgg ttgagcaagc gggtgagacg gctcctggaa agaagagacc gttgattgaa     2700

tccccccagc agcccgactc ctccacgggt atcggcaaaa aaggcaagca gccggctaaa     2760

aagaagctcg ttttcgaaga cgaaactgga gcaggcgacg gaccccctga gggatcaact     2820

tccggagcca tgtctgatga cagtgagatg cgtgcagcag ctggcggagc tgcagtcgag     2880

ggsggacaag gtgccgatgg agtgggtaat gcctcgggtg attggcattg cgattccacc     2940

tggtctgagg gccacgtcac gaccaccagc accagaacct gggtcttgcc cacctacaac     3000

aaccacctnt acaagcgact cggagagagc ctgcagtcca acacctacaa cggattctcc     3060

accccctggg gatactttga cttcaaccgc ttccactgcc acttctcacc acgtgactgg     3120

cagcgactca tcaacaacaa ctggggcatg cgacccaaag ccatgcgggt caaaatcttc     3180

aacatccagg tcaaggaggt cacgacgtcg aacggcgaga caacggtggc taataacctt     3240

accagcacgg ttcagatctt tgcggactcg tcgtacgaac tgccgtacgt gatggatgcg     3300

ggtcaagagg gcagcctgcc tccttttccc aacgacgtct ttatggtgcc ccagtacggc     3360

tactgtggac tggtgaccgg caacacttcg cagcaacaga ctgacagaaa tgccttctac     3420

tgcctggagt actttccttc gcagatgctg cggactggca acaactttga aattacgtac     3480

agttttgaga aggtgccttt ccactcgatg tacgcgcaca gccagagcct ggaccggctg     3540

atgaaccctc tcatcgacca gtacctgtgg ggactgcaat cgaccaccac cggaaccacc     3600

ctgaatgccg ggactgccac caccaacttt accaagctgc ggcctaccaa cttttccaac     3660

tttaaaaaga actggctgcc cgggccttca atcaagcagc agggcttctc aaagactgcc     3720

aatcaaaact acaagatccc tgccaccggg tcagacagtc tcatcaaata cgagacgcac     3780

agcactctgg acggaagatg gagtgccctg acccccggac ctccaatggc cacggctgga     3840

cctgcggaca gcaagttcag caacagccag ctcatctttg cggggcctaa acagaacggc     3900

aacacggcca ccgtacccgg gactctgatc ttcacctctg aggaggagct ggcagccacc     3960

aacgccaccg atacggacat gtggggcaac ctacctggcg gtgaccagag caacagcaac     4020

ctgccgaccg tggacagact gacagccttg ggagccgtgc ctggaatggt ctggcaaaac     4080

agagacattt actaccaggg tcccatttgg gccaagattc ctcataccga tggacacttt     4140

cacccctcac cgctgattgg tgggtttggg ctgaaacacc cgcctcctca aatttttatc     4200

aagaacaccc cggtacctgc gaatcctgca acgaccttca gctctactcc ggtaaactcc     4260

ttcattactc agtacagcac tggccaggtg tcggtgcaga ttgactggga gatccagaag     4320

gagcggtcca aacgctggaa ccccgaggtc cagtttacct ccaactacgg acagcaaaac     4380

tctctgttgt gggctcccga tgcggctggg aaatacactg agcctagggc tatcggtacc     4440

cgctacctca cccaccacct gtaataacct gttaatcaat aaaccggttt attcgtttca     4500

gttgaacttt ggtctccgtg tccttcttat cttatctcgt ttccatggct actgcgtaca     4560

taagcagcgg cctgcggcgc ttgcgcttcg cggtttacaa ctgccggtta atcagtaact     4620

tctggcaaac catgatgatg gagttggcca ctccctctat gcgcgctcgc tcactcactc     4680

ggccctggag accaaaggtc tccagactgc cggcctctgg ccggcagggc cgagtgagtg     4740

agcgagcgcg catagaggga gtggccaa                                        4768


<210>  62
<211>  3098
<212>  PRT
<213>  Adeno-associated virus

<400>  62

Gly Ala Ala Thr Thr Cys Gly Cys Cys Cys Thr Thr Thr Cys Thr Ala 
1               5                   10                  15      


Cys Gly Gly Cys Thr Gly Cys Gly Thr Cys Ala Ala Cys Thr Gly Gly 
            20                  25                  30          


Ala Cys Cys Ala Ala Thr Gly Ala Gly Ala Ala Cys Thr Thr Thr Cys 
        35                  40                  45              


Cys Cys Thr Thr Cys Ala Ala Cys Gly Ala Thr Thr Gly Cys Gly Thr 
    50                  55                  60                  


Cys Gly Ala Cys Ala Ala Gly Ala Thr Gly Gly Thr Gly Ala Thr Cys 
65                  70                  75                  80  


Thr Gly Gly Thr Gly Gly Gly Ala Gly Gly Ala Gly Gly Gly Cys Ala 
                85                  90                  95      


Ala Gly Ala Thr Gly Ala Cys Gly Gly Cys Cys Ala Ala Gly Gly Thr 
            100                 105                 110         


Cys Gly Thr Gly Gly Ala Gly Thr Cys Cys Gly Cys Cys Ala Ala Gly 
        115                 120                 125             


Gly Cys Cys Ala Thr Thr Cys Thr Cys Gly Gly Cys Gly Gly Cys Ala 
    130                 135                 140                 


Gly Cys Ala Ala Gly Gly Thr Gly Cys Gly Cys Gly Thr Gly Gly Ala 
145                 150                 155                 160 


Cys Cys Ala Ala Ala Ala Gly Thr Gly Cys Ala Ala Gly Thr Cys Thr 
                165                 170                 175     


Thr Cys Cys Gly Cys Cys Cys Ala Gly Ala Thr Cys Gly Ala Thr Cys 
            180                 185                 190         


Cys Cys Ala Cys Cys Cys Cys Cys Gly Thr Gly Ala Thr Cys Gly Thr 
        195                 200                 205             


Cys Ala Cys Thr Thr Cys Cys Ala Ala Cys Ala Cys Cys Ala Ala Cys 
    210                 215                 220                 


Ala Thr Gly Thr Gly Cys Gly Cys Thr Gly Thr Gly Ala Thr Thr Gly 
225                 230                 235                 240 


Ala Cys Gly Gly Gly Ala Ala Cys Ala Gly Cys Ala Cys Cys Ala Cys 
                245                 250                 255     


Cys Thr Thr Cys Gly Ala Gly Cys Ala Cys Cys Ala Gly Cys Ala Gly 
            260                 265                 270         


Cys Cys Gly Thr Thr Ala Cys Ala Ala Gly Ala Cys Cys Gly Gly Ala 
        275                 280                 285             


Thr Gly Thr Thr Cys Ala Ala Ala Thr Thr Thr Gly Ala Ala Cys Thr 
    290                 295                 300                 


Cys Ala Cys Cys Cys Gly Cys Cys Gly Thr Cys Thr Gly Gly Ala Gly 
305                 310                 315                 320 


Cys Ala Cys Gly Ala Cys Thr Thr Thr Gly Gly Cys Ala Ala Gly Gly 
                325                 330                 335     


Thr Gly Ala Cys Ala Ala Ala Gly Cys Ala Gly Gly Ala Ala Gly Thr 
            340                 345                 350         


Cys Ala Ala Ala Gly Ala Gly Thr Thr Cys Thr Thr Cys Cys Gly Cys 
        355                 360                 365             


Thr Gly Gly Gly Cys Gly Cys Ala Gly Gly Ala Thr Cys Ala Cys Gly 
    370                 375                 380                 


Thr Gly Ala Cys Cys Gly Ala Gly Gly Thr Gly Gly Cys Gly Cys Ala 
385                 390                 395                 400 


Thr Gly Ala Gly Thr Thr Cys Thr Ala Cys Gly Thr Cys Ala Gly Ala 
                405                 410                 415     


Ala Ala Gly Gly Gly Thr Gly Gly Ala Gly Cys Cys Ala Ala Cys Ala 
            420                 425                 430         


Ala Gly Ala Gly Ala Cys Cys Cys Gly Cys Cys Cys Cys Cys Gly Ala 
        435                 440                 445             


Thr Gly Ala Cys Gly Cys Gly Gly Ala Thr Ala Ala Ala Ala Gly Cys 
    450                 455                 460                 


Gly Ala Gly Cys Cys Cys Ala Ala Gly Cys Gly Gly Gly Cys Cys Thr 
465                 470                 475                 480 


Gly Cys Cys Cys Cys Thr Cys Ala Gly Thr Cys Gly Cys Gly Gly Ala 
                485                 490                 495     


Thr Cys Cys Ala Thr Cys Gly Ala Cys Gly Thr Cys Ala Gly Ala Cys 
            500                 505                 510         


Gly Cys Gly Gly Ala Ala Gly Gly Ala Gly Cys Thr Cys Cys Gly Gly 
        515                 520                 525             


Thr Gly Gly Ala Cys Thr Thr Thr Gly Cys Cys Gly Ala Cys Ala Gly 
    530                 535                 540                 


Gly Thr Ala Cys Cys Ala Ala Ala Ala Cys Ala Ala Ala Thr Gly Thr 
545                 550                 555                 560 


Thr Cys Thr Cys Gly Thr Cys Ala Cys Gly Cys Gly Gly Gly Cys Ala 
                565                 570                 575     


Thr Gly Cys Thr Thr Cys Ala Gly Ala Thr Gly Cys Thr Gly Thr Thr 
            580                 585                 590         


Thr Cys Cys Cys Thr Gly Cys Ala Ala Gly Ala Cys Ala Thr Gly Cys 
        595                 600                 605             


Gly Ala Gly Ala Gly Ala Ala Thr Gly Ala Ala Thr Cys Ala Gly Ala 
    610                 615                 620                 


Ala Thr Thr Thr Cys Ala Ala Cys Ala Thr Thr Thr Gly Cys Thr Thr 
625                 630                 635                 640 


Cys Ala Cys Gly Cys Ala Cys Gly Gly Gly Ala Cys Cys Ala Gly Ala 
                645                 650                 655     


Gly Ala Cys Thr Gly Thr Thr Cys Ala Gly Ala Ala Thr Gly Thr Thr 
            660                 665                 670         


Thr Cys Cys Cys Cys Gly Gly Cys Gly Thr Gly Thr Cys Ala Gly Ala 
        675                 680                 685             


Ala Thr Cys Thr Cys Ala Ala Cys Cys Gly Gly Thr Cys Gly Thr Cys 
    690                 695                 700                 


Ala Gly Ala Ala Ala Gly Ala Gly Gly Ala Cys Gly Thr Ala Thr Cys 
705                 710                 715                 720 


Gly Gly Ala Ala Ala Cys Thr Cys Thr Gly Thr Gly Cys Cys Ala Thr 
                725                 730                 735     


Thr Cys Ala Thr Cys Ala Thr Cys Thr Gly Cys Thr Gly Gly Gly Gly 
            740                 745                 750         


Cys Gly Gly Gly Cys Thr Cys Cys Cys Gly Ala Gly Ala Thr Thr Gly 
        755                 760                 765             


Cys Thr Thr Gly Cys Thr Cys Gly Gly Cys Cys Thr Gly Cys Gly Ala 
    770                 775                 780                 


Thr Cys Thr Gly Gly Thr Cys Ala Ala Cys Gly Thr Gly Gly Ala Cys 
785                 790                 795                 800 


Cys Thr Gly Gly Ala Thr Gly Ala Cys Cys Gly Thr Gly Thr Thr Thr 
                805                 810                 815     


Cys Thr Gly Ala Gly Cys Ala Ala Thr Ala Ala Ala Thr Gly Ala Cys 
            820                 825                 830         


Thr Thr Ala Ala Ala Cys Cys Ala Gly Gly Thr Ala Thr Gly Gly Cys 
        835                 840                 845             


Thr Gly Cys Cys Gly Ala Thr Gly Gly Thr Thr Ala Thr Cys Thr Thr 
    850                 855                 860                 


Cys Cys Ala Gly Ala Thr Thr Gly Gly Cys Thr Cys Gly Ala Gly Gly 
865                 870                 875                 880 


Ala Cys Ala Ala Cys Cys Thr Cys Thr Cys Thr Gly Ala Gly Gly Gly 
                885                 890                 895     


Cys Ala Thr Thr Cys Gly Cys Gly Ala Gly Thr Gly Gly Thr Gly Gly 
            900                 905                 910         


Gly Ala Cys Thr Thr Gly Ala Ala Ala Cys Cys Thr Gly Gly Ala Gly 
        915                 920                 925             


Cys Cys Cys Cys Gly Ala Ala Ala Cys Cys Cys Ala Ala Ala Gly Cys 
    930                 935                 940                 


Cys Ala Ala Cys Cys Ala Gly Cys Ala Ala Ala Ala Gly Cys Ala Gly 
945                 950                 955                 960 


Gly Ala Cys Gly Ala Cys Gly Gly Cys Cys Gly Gly Gly Gly Thr Cys 
                965                 970                 975     


Thr Gly Gly Thr Gly Cys Thr Thr Cys Cys Thr Gly Gly Cys Thr Ala 
            980                 985                 990         


Cys Ala Ala Gly Thr Ala Cys Cys  Thr Cys Gly Gly Ala  Cys Cys Cys 
        995                 1000                 1005             


Thr Thr  Cys Ala Ala Cys Gly  Gly Ala Cys Thr Cys  Gly Ala Cys 
    1010                 1015                 1020             


Ala Ala  Gly Gly Gly Ala Gly  Ala Gly Cys Cys Gly  Gly Thr Cys 
    1025                 1030                 1035             


Ala Ala  Cys Gly Ala Gly Gly  Cys Ala Gly Ala Cys  Gly Cys Cys 
    1040                 1045                 1050             


Gly Cys  Gly Gly Cys Cys Cys  Thr Cys Gly Ala Gly  Cys Ala Cys 
    1055                 1060                 1065             


Gly Ala  Cys Ala Ala Gly Gly  Cys Cys Thr Ala Cys  Gly Ala Cys 
    1070                 1075                 1080             


Ala Ala  Gly Cys Ala Gly Cys  Thr Cys Gly Ala Gly  Cys Ala Gly 
    1085                 1090                 1095             


Gly Gly  Gly Gly Ala Cys Ala  Ala Cys Cys Cys Gly  Thr Ala Cys 
    1100                 1105                 1110             


Cys Thr  Cys Ala Ala Gly Thr  Ala Cys Ala Ala Cys  Cys Ala Cys 
    1115                 1120                 1125             


Gly Cys  Cys Gly Ala Cys Gly  Cys Cys Gly Ala Gly  Thr Thr Thr 
    1130                 1135                 1140             


Cys Ala  Gly Gly Ala Gly Cys  Gly Thr Cys Thr Thr  Cys Ala Ala 
    1145                 1150                 1155             


Gly Ala  Ala Gly Ala Thr Ala  Cys Gly Thr Cys Thr  Thr Thr Thr 
    1160                 1165                 1170             


Gly Gly  Gly Gly Gly Cys Ala  Ala Cys Cys Thr Cys  Gly Gly Gly 
    1175                 1180                 1185             


Cys Gly  Ala Gly Cys Ala Gly  Thr Cys Thr Thr Cys  Cys Ala Gly 
    1190                 1195                 1200             


Gly Cys  Cys Ala Ala Gly Ala  Ala Gly Cys Gly Gly  Gly Thr Thr 
    1205                 1210                 1215             


Cys Thr  Cys Gly Ala Ala Cys  Cys Thr Cys Thr Cys  Gly Gly Thr 
    1220                 1225                 1230             


Cys Thr  Gly Gly Thr Thr Gly  Ala Gly Gly Ala Ala  Gly Gly Cys 
    1235                 1240                 1245             


Gly Cys  Thr Ala Ala Gly Ala  Cys Gly Gly Cys Thr  Cys Cys Thr 
    1250                 1255                 1260             


Gly Gly  Ala Ala Ala Gly Ala  Ala Gly Ala Gly Ala  Cys Cys Cys 
    1265                 1270                 1275             


Ala Thr  Ala Gly Ala Ala Thr  Cys Cys Cys Cys Cys  Gly Ala Cys 
    1280                 1285                 1290             


Thr Cys  Cys Thr Cys Cys Ala  Cys Gly Gly Gly Cys  Ala Thr Cys 
    1295                 1300                 1305             


Gly Gly  Cys Ala Ala Gly Ala  Ala Ala Gly Gly Cys  Cys Ala Gly 
    1310                 1315                 1320             


Cys Ala  Gly Cys Cys Cys Gly  Cys Thr Ala Ala Ala  Ala Ala Gly 
    1325                 1330                 1335             


Ala Ala  Gly Cys Thr Cys Ala  Ala Cys Thr Thr Thr  Gly Gly Gly 
    1340                 1345                 1350             


Cys Ala  Gly Ala Cys Thr Gly  Gly Cys Gly Ala Cys  Thr Cys Ala 
    1355                 1360                 1365             


Gly Ala  Gly Thr Cys Ala Gly  Thr Gly Cys Cys Cys  Gly Ala Cys 
    1370                 1375                 1380             


Cys Cys  Cys Cys Ala Ala Cys  Cys Thr Cys Thr Cys  Gly Gly Ala 
    1385                 1390                 1395             


Gly Ala  Ala Cys Cys Thr Cys  Cys Cys Gly Cys Cys  Gly Cys Gly 
    1400                 1405                 1410             


Cys Cys  Cys Thr Cys Ala Gly  Gly Thr Cys Thr Gly  Gly Gly Ala 
    1415                 1420                 1425             


Thr Cys  Thr Gly Gly Thr Ala  Cys Ala Ala Thr Gly  Gly Cys Thr 
    1430                 1435                 1440             


Gly Cys  Ala Gly Gly Cys Gly  Gly Thr Gly Gly Cys  Gly Cys Ala 
    1445                 1450                 1455             


Cys Cys  Ala Ala Thr Gly Gly  Cys Ala Gly Ala Cys  Ala Ala Thr 
    1460                 1465                 1470             


Ala Ala  Cys Gly Ala Ala Gly  Gly Cys Gly Cys Cys  Gly Ala Cys 
    1475                 1480                 1485             


Gly Gly  Ala Gly Thr Gly Gly  Gly Thr Ala Ala Thr  Gly Cys Cys 
    1490                 1495                 1500             


Thr Cys  Cys Gly Gly Ala Ala  Ala Thr Thr Gly Gly  Cys Ala Thr 
    1505                 1510                 1515             


Thr Gly  Cys Gly Ala Thr Thr  Cys Cys Ala Cys Ala  Thr Gly Gly 
    1520                 1525                 1530             


Cys Thr  Gly Gly Gly Cys Gly  Ala Cys Ala Gly Ala  Gly Thr Cys 
    1535                 1540                 1545             


Ala Thr  Cys Ala Cys Cys Ala  Cys Cys Ala Gly Cys  Ala Cys Cys 
    1550                 1555                 1560             


Cys Gly  Cys Ala Cys Cys Thr  Gly Gly Gly Cys Cys  Cys Thr Gly 
    1565                 1570                 1575             


Cys Cys  Cys Ala Cys Cys Thr  Ala Cys Ala Ala Cys  Ala Ala Cys 
    1580                 1585                 1590             


Cys Ala  Cys Cys Thr Cys Thr  Ala Cys Ala Ala Gly  Cys Ala Gly 
    1595                 1600                 1605             


Ala Thr  Ala Thr Cys Ala Ala  Gly Thr Cys Ala Gly  Ala Gly Cys 
    1610                 1615                 1620             


Gly Gly  Gly Gly Cys Thr Ala  Cys Cys Ala Ala Cys  Gly Ala Cys 
    1625                 1630                 1635             


Ala Ala  Cys Cys Ala Cys Thr  Thr Cys Thr Thr Cys  Gly Gly Cys 
    1640                 1645                 1650             


Thr Ala  Cys Ala Gly Cys Ala  Cys Cys Cys Cys Cys  Thr Gly Gly 
    1655                 1660                 1665             


Gly Gly  Cys Thr Ala Thr Thr  Thr Thr Gly Ala Cys  Thr Thr Cys 
    1670                 1675                 1680             


Ala Ala  Cys Ala Gly Ala Thr  Thr Cys Cys Ala Cys  Thr Gly Cys 
    1685                 1690                 1695             


Cys Ala  Cys Thr Thr Cys Thr  Cys Ala Cys Cys Ala  Cys Gly Thr 
    1700                 1705                 1710             


Gly Ala  Cys Thr Gly Gly Cys  Ala Gly Cys Gly Ala  Cys Thr Cys 
    1715                 1720                 1725             


Ala Thr  Cys Ala Ala Cys Ala  Ala Cys Ala Ala Cys  Thr Gly Gly 
    1730                 1735                 1740             


Gly Gly  Ala Thr Thr Cys Cys  Gly Gly Cys Cys Cys  Ala Gly Ala 
    1745                 1750                 1755             


Ala Ala  Gly Cys Thr Gly Cys  Gly Gly Thr Thr Cys  Ala Ala Gly 
    1760                 1765                 1770             


Thr Thr  Gly Thr Thr Cys Ala  Ala Cys Ala Thr Cys  Cys Ala Gly 
    1775                 1780                 1785             


Gly Thr  Cys Ala Ala Gly Gly  Ala Gly Gly Thr Cys  Ala Cys Gly 
    1790                 1795                 1800             


Ala Cys  Gly Ala Ala Cys Gly  Ala Cys Gly Gly Cys  Gly Thr Thr 
    1805                 1810                 1815             


Ala Cys  Gly Ala Cys Cys Ala  Thr Cys Gly Cys Thr  Ala Ala Thr 
    1820                 1825                 1830             


Ala Ala  Cys Cys Thr Thr Ala  Cys Cys Ala Gly Cys  Ala Cys Gly 
    1835                 1840                 1845             


Ala Thr  Thr Cys Ala Gly Gly  Thr Cys Thr Thr Cys  Thr Cys Gly 
    1850                 1855                 1860             


Gly Ala  Cys Thr Cys Gly Gly  Ala Gly Thr Ala Cys  Cys Ala Ala 
    1865                 1870                 1875             


Cys Thr  Gly Cys Cys Gly Thr  Ala Cys Gly Thr Cys  Cys Thr Cys 
    1880                 1885                 1890             


Gly Gly  Cys Thr Cys Thr Gly  Cys Gly Cys Ala Cys  Cys Ala Gly 
    1895                 1900                 1905             


Gly Gly  Cys Thr Gly Cys Cys  Thr Cys Cys Cys Thr  Cys Cys Gly 
    1910                 1915                 1920             


Thr Thr  Cys Cys Cys Thr Gly  Cys Gly Gly Ala Cys  Gly Thr Gly 
    1925                 1930                 1935             


Thr Thr  Cys Ala Thr Gly Ala  Thr Thr Cys Cys Thr  Cys Ala Gly 
    1940                 1945                 1950             


Thr Ala  Cys Gly Gly Ala Thr  Ala Thr Cys Thr Gly  Ala Cys Thr 
    1955                 1960                 1965             


Cys Thr  Ala Ala Ala Cys Ala  Ala Cys Gly Gly Cys  Ala Gly Thr 
    1970                 1975                 1980             


Cys Ala  Gly Thr Cys Thr Gly  Thr Gly Gly Gly Ala  Cys Gly Thr 
    1985                 1990                 1995             


Thr Cys  Cys Thr Cys Cys Thr  Thr Cys Thr Ala Cys  Thr Gly Cys 
    2000                 2005                 2010             


Cys Thr  Gly Gly Ala Gly Thr  Ala Cys Thr Thr Thr  Cys Cys Thr 
    2015                 2020                 2025             


Thr Cys  Thr Cys Ala Gly Ala  Thr Gly Cys Thr Gly  Ala Gly Ala 
    2030                 2035                 2040             


Ala Cys  Gly Gly Gly Cys Ala  Ala Thr Ala Ala Cys  Thr Thr Thr 
    2045                 2050                 2055             


Gly Ala  Ala Thr Thr Cys Ala  Gly Cys Thr Ala Cys  Ala Cys Cys 
    2060                 2065                 2070             


Thr Thr  Thr Gly Ala Gly Gly  Ala Ala Gly Thr Gly  Cys Cys Thr 
    2075                 2080                 2085             


Thr Thr  Cys Cys Ala Cys Ala  Gly Cys Ala Gly Cys  Thr Ala Thr 
    2090                 2095                 2100             


Gly Cys  Gly Cys Ala Cys Ala  Gly Cys Cys Ala Gly  Ala Gly Cys 
    2105                 2110                 2115             


Cys Thr  Gly Gly Ala Cys Cys  Gly Gly Cys Thr Gly  Ala Thr Gly 
    2120                 2125                 2130             


Ala Ala  Thr Cys Cys Cys Cys  Thr Cys Ala Thr Cys  Gly Ala Cys 
    2135                 2140                 2145             


Cys Ala  Gly Thr Ala Cys Cys  Thr Gly Thr Ala Cys  Thr Ala Cys 
    2150                 2155                 2160             


Cys Thr  Gly Gly Cys Cys Cys  Gly Gly Ala Cys Cys  Cys Ala Gly 
    2165                 2170                 2175             


Ala Gly  Cys Ala Cys Thr Ala  Cys Gly Gly Gly Gly  Thr Cys Cys 
    2180                 2185                 2190             


Ala Cys  Ala Ala Gly Gly Gly  Ala Gly Cys Thr Gly  Cys Ala Gly 
    2195                 2200                 2205             


Thr Thr  Cys Cys Ala Thr Cys  Ala Gly Gly Cys Thr  Gly Gly Gly 
    2210                 2215                 2220             


Cys Cys  Cys Ala Ala Cys Ala  Cys Cys Ala Thr Gly  Gly Cys Cys 
    2225                 2230                 2235             


Gly Ala  Gly Cys Ala Ala Thr  Cys Ala Ala Ala Gly  Ala Ala Cys 
    2240                 2245                 2250             


Thr Gly  Gly Cys Thr Gly Cys  Cys Cys Gly Gly Ala  Cys Cys Cys 
    2255                 2260                 2265             


Thr Gly  Thr Thr Ala Thr Cys  Gly Gly Cys Ala Gly  Cys Ala Gly 
    2270                 2275                 2280             


Ala Gly  Ala Cys Thr Gly Thr  Cys Ala Ala Ala Ala  Ala Ala Cys 
    2285                 2290                 2295             


Ala Thr  Ala Gly Ala Cys Ala  Gly Cys Ala Ala Cys  Ala Ala Cys 
    2300                 2305                 2310             


Ala Ala  Cys Ala Gly Thr Ala  Ala Cys Thr Thr Thr  Gly Cys Cys 
    2315                 2320                 2325             


Thr Gly  Gly Ala Cys Cys Gly  Gly Gly Gly Cys Cys  Ala Cys Thr 
    2330                 2335                 2340             


Ala Ala  Ala Thr Ala Cys Cys  Ala Thr Cys Thr Gly  Ala Ala Thr 
    2345                 2350                 2355             


Gly Gly  Thr Ala Gly Ala Ala  Ala Thr Thr Cys Ala  Thr Thr Ala 
    2360                 2365                 2370             


Ala Cys  Cys Ala Ala Cys Cys  Cys Gly Gly Gly Cys  Gly Thr Ala 
    2375                 2380                 2385             


Gly Cys  Cys Ala Thr Gly Gly  Cys Cys Ala Cys Cys  Ala Ala Cys 
    2390                 2395                 2400             


Ala Ala  Gly Gly Ala Cys Gly  Ala Cys Gly Ala Gly  Gly Ala Cys 
    2405                 2410                 2415             


Cys Ala  Gly Thr Thr Cys Thr  Thr Thr Cys Cys Cys  Ala Thr Cys 
    2420                 2425                 2430             


Ala Ala  Cys Gly Gly Ala Gly  Thr Gly Cys Thr Gly  Gly Thr Thr 
    2435                 2440                 2445             


Thr Thr  Thr Gly Gly Cys Gly  Ala Ala Ala Cys Gly  Gly Gly Gly 
    2450                 2455                 2460             


Gly Cys  Thr Gly Cys Cys Ala  Ala Cys Ala Ala Gly  Ala Cys Ala 
    2465                 2470                 2475             


Ala Cys  Gly Cys Thr Gly Gly  Ala Ala Ala Ala Cys  Gly Thr Gly 
    2480                 2485                 2490             


Cys Thr  Ala Ala Thr Gly Ala  Cys Cys Ala Gly Cys  Gly Ala Gly 
    2495                 2500                 2505             


Gly Ala  Gly Gly Ala Gly Ala  Thr Cys Ala Ala Ala  Ala Cys Cys 
    2510                 2515                 2520             


Ala Cys  Cys Ala Ala Thr Cys  Cys Cys Gly Thr Gly  Gly Cys Thr 
    2525                 2530                 2535             


Ala Cys  Ala Gly Ala Ala Gly  Ala Ala Thr Ala Cys  Gly Gly Thr 
    2540                 2545                 2550             


Gly Thr  Gly Gly Thr Cys Thr  Cys Cys Ala Gly Cys  Ala Ala Cys 
    2555                 2560                 2565             


Cys Thr  Gly Cys Ala Ala Thr  Cys Gly Thr Cys Thr  Ala Cys Gly 
    2570                 2575                 2580             


Gly Cys  Cys Gly Gly Ala Cys  Cys Cys Cys Ala Gly  Ala Cys Ala 
    2585                 2590                 2595             


Cys Ala  Gly Ala Cys Thr Gly  Thr Cys Ala Ala Cys  Ala Gly Cys 
    2600                 2605                 2610             


Cys Ala  Gly Gly Gly Gly Gly  Cys Thr Cys Thr Gly  Cys Cys Cys 
    2615                 2620                 2625             


Gly Gly  Cys Ala Thr Gly Gly  Thr Cys Thr Gly Gly  Cys Ala Gly 
    2630                 2635                 2640             


Ala Ala  Cys Cys Gly Gly Gly  Ala Cys Gly Thr Gly  Thr Ala Cys 
    2645                 2650                 2655             


Cys Thr  Gly Cys Ala Gly Gly  Gly Thr Cys Cys Cys  Ala Thr Cys 
    2660                 2665                 2670             


Thr Gly  Gly Gly Cys Cys Ala  Ala Ala Ala Thr Thr  Cys Cys Thr 
    2675                 2680                 2685             


Cys Ala  Cys Ala Cys Gly Gly  Ala Cys Gly Gly Cys  Ala Ala Cys 
    2690                 2695                 2700             


Thr Thr  Thr Cys Ala Cys Cys  Cys Gly Thr Cys Thr  Cys Cys Cys 
    2705                 2710                 2715             


Cys Thr  Gly Ala Thr Gly Gly  Gly Cys Gly Gly Ala  Thr Thr Thr 
    2720                 2725                 2730             


Gly Gly  Ala Cys Thr Cys Ala  Ala Ala Cys Ala Cys  Cys Cys Gly 
    2735                 2740                 2745             


Cys Cys  Thr Cys Cys Thr Cys  Ala Ala Ala Thr Thr  Cys Thr Cys 
    2750                 2755                 2760             


Ala Thr  Cys Ala Ala Ala Ala  Ala Cys Ala Cys Cys  Cys Cys Gly 
    2765                 2770                 2775             


Gly Thr  Ala Cys Cys Thr Gly  Cys Thr Ala Ala Thr  Cys Cys Thr 
    2780                 2785                 2790             


Cys Cys  Ala Gly Ala Gly Gly  Thr Gly Thr Thr Thr  Ala Cys Thr 
    2795                 2800                 2805             


Cys Cys  Thr Gly Cys Cys Ala  Ala Gly Thr Thr Thr  Gly Cys Cys 
    2810                 2815                 2820             


Thr Cys  Ala Thr Thr Thr Ala  Thr Cys Ala Cys Gly  Cys Ala Gly 
    2825                 2830                 2835             


Thr Ala  Cys Ala Gly Cys Ala  Cys Cys Gly Gly Cys  Cys Ala Gly 
    2840                 2845                 2850             


Gly Thr  Cys Ala Gly Cys Gly  Thr Gly Gly Ala Gly  Ala Thr Cys 
    2855                 2860                 2865             


Gly Ala  Gly Thr Gly Gly Gly  Ala Ala Cys Thr Gly  Cys Ala Gly 
    2870                 2875                 2880             


Ala Ala  Ala Gly Ala Ala Ala  Ala Cys Ala Gly Cys  Ala Ala Ala 
    2885                 2890                 2895             


Cys Gly  Cys Thr Gly Gly Ala  Ala Thr Cys Cys Ala  Gly Ala Gly 
    2900                 2905                 2910             


Ala Thr  Thr Cys Ala Gly Thr  Ala Cys Ala Cys Cys  Thr Cys Ala 
    2915                 2920                 2925             


Ala Ala  Thr Thr Ala Thr Gly  Cys Cys Ala Ala Gly  Thr Cys Thr 
    2930                 2935                 2940             


Ala Ala  Thr Ala Ala Thr Gly  Thr Gly Gly Ala Ala  Thr Thr Thr 
    2945                 2950                 2955             


Gly Cys  Thr Gly Thr Cys Ala  Ala Cys Ala Ala Cys  Gly Ala Ala 
    2960                 2965                 2970             


Gly Gly  Gly Gly Thr Thr Thr  Ala Thr Ala Cys Thr  Gly Ala Gly 
    2975                 2980                 2985             


Cys Cys  Thr Cys Gly Cys Cys  Cys Cys Ala Thr Thr  Gly Gly Cys 
    2990                 2995                 3000             


Ala Cys  Cys Cys Gly Thr Thr  Ala Cys Cys Thr Cys  Ala Cys Cys 
    3005                 3010                 3015             


Cys Gly  Thr Ala Ala Cys Cys  Thr Gly Thr Ala Ala  Thr Thr Gly 
    3020                 3025                 3030             


Cys Cys  Thr Gly Thr Thr Ala  Ala Thr Cys Ala Ala  Thr Ala Ala 
    3035                 3040                 3045             


Ala Cys  Cys Gly Gly Thr Thr  Ala Ala Thr Thr Cys  Gly Thr Thr 
    3050                 3055                 3060             


Thr Cys  Ala Gly Thr Thr Gly  Ala Ala Cys Thr Thr  Thr Gly Gly 
    3065                 3070                 3075             


Thr Cys  Thr Cys Thr Gly Cys  Gly Ala Ala Gly Gly  Gly Cys Gly 
    3080                 3085                 3090             


Ala Ala  Thr Thr Cys 
    3095             


<210>  63
<211>  728
<212>  PRT
<213>  Adeno-associated virus

<400>  63

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Glu Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210>  64
<211>  2495
<212>  DNA
<213>  Adeno-associated virus

<400>  64
gaattcgccc tttctacggc tgcgtcaact agaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattcatcat ctgctggggc gggctcccga gattgcttgc tcggcctgcg      180

atctggtcaa cgtggacctg gatgactgtg tttctgagca ataaatgact taaaccaggt      240

atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc      300

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      360

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      420

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      480

aagcagctcg agcaggggga caacccgtac ctcaagtaca accacgccga cgccgagttt      540

caggagcgtc ttcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      600

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      660

ggaaagaaga gacccataga atcccccgac tcctccacgg gcatcggcaa gaaaggccag      720

cagcccgcta aaaagaagct caactttggg cagactggcg actcagagtc agtgcccgac      780

cctcaaccaa tcggagaacc ccccgcaggc ccctctggtc tgggatctgg tacaatggct      840

gcaggcggtg gcgctccaat ggcagacaat aacgaaggcg ccgacggagt gggtaatgcc      900

tccggaaatt ggcattgcga ttccacatgg ctgggcgaca gagtcatcac caccagcacc      960

cgcacctggg ccctgcccac ctacaacaac cacctctaca agcagatatc aagtcagagc     1020

ggggctacca acgacaacca cttcttcggc tacagcaccc cctggggcta ttttgacttc     1080

aacagattcc actgccactt ctcaccacgt gactggcagc gactcatcaa caacaactgg     1140

ggattccggc ccagaaagct gcggttcaag ttgttcaaca tccaggtcaa ggaggtcacg     1200

acgaacgacg gcgttacgac catcgctaat aaccttacca gcacgattca ggtcttctcg     1260

gactcggagt accaactgcc gtacgtcctc ggctctgcgc accagggctg cctccctccg     1320

ttccctgcgg acgtgttcat gattcctcag tacggatatc tgactctaaa caacggcagt     1380

cagtctgtgg gacgttcctc cttctactgc ctggagtact ttccttctca gatgctgaga     1440

acgggcaata actttgaatt cagctacacc tttgaggaag tgcctttcca cagcagctat     1500

gcgcacagcc agagcctgga ccggctgatg aatcccctca tcgaccagta cctgtactac     1560

ctggcccgga cccagagcac tacggggtcc acaagggagc tgcagttcca tcaggctggg     1620

cccaacacca tggccgagca atcaaagaac tggctgcccg gaccctgtta tcggcagcag     1680

agactgtcaa aaaacataga cagcaacaac accagtaact ttgcctggac cggggccact     1740

aaataccatc tgaatggtag aaattcatta accaacccgg gcgtagccat ggccaccaac     1800

aaggacgacg aggaccagtt ctttcccatc aacggagtgc tggtttttgg caaaacgggg     1860

gctgccaaca agacaacgct ggaaaacgtg ctaatgacca gcgaggagga gatcaaaacc     1920

accaatcccg tggctacaga acagtacggt gtggtctcca gcaacctgca atcgtctacg     1980

gccggacccc agacacagac tgtcaacagc cagggggctc tgcccggcat ggtctggcag     2040

aaccgggacg tgtacctgca gggtcccatc tgggccaaaa ttcctcacac ggacggcaac     2100

tttcacccgt ctcccctgat gggcggattt ggactcaaac acccgcctcc tcaaattctc     2160

atcaaaaaca ccccggtacc tgctaatcct ccagaggtgt ttactcctgc caagtttgcc     2220

tcatttatca cgcagtacag caccggccag gtcagcgtgg agatcgagtg ggaactgcag     2280

aaagaaaaca gcaaacgctg gaatccagag attcagtaca cctcaaatta tgccaagtct     2340

aataatgtgg aatttgctgt caacaacgaa ggggtttata ctgagcctcg ccccattggc     2400

acccgttacc tcacccgtaa cctgtaattg cctgttaatc aataaaccgg ttaattcgtt     2460

tcagttgaac tttggtctct gcgaagggcg aattc                                2495


<210>  65
<211>  728
<212>  PRT
<213>  Adeno-associated virus

<400>  65

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Gly Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Thr Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210>  66
<211>  2504
<212>  DNA
<213>  Adeno-associated virus

<400>  66
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattcatcat ctgctggggc gggctcccga gattgcttgc tcggcctgcg      180

atctggtcaa cgtggacctg gatgactgtg tttctgagca ataaatgact taaaccaggt      240

atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc      300

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      360

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      420

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      480

aagcagctcg agcaggggga caacccgtac ctcaagtaca accacgccga cgccgagttt      540

caggagcgtc ttcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      600

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      660

ggaaagaaga gacccataga atcccccgac tcctccacgg gcatcggcaa gaaaggccag      720

cagcccgcta aaaagaagct caactttggg cagactggcg actcagagtc agtgcccgac      780

cctcaaccaa tcggagaacc ccccgcaggc ccctctggtc tgggatctgg tacaatggct      840

gcaggcggtg gcgctccaat ggcagacaat aacgaaggcg ccgacggagt gggtaatgcc      900

tccggaaatt ggcattgcga ttccacatgg ctgggcgaca gagtcatcac caccagcacc      960

cgcacctggg ccctgcccac ctacaacaac cacctctaca agcagatatc aagtcagagc     1020

ggggctacca acgacaacca cttcttcggc tacagcaccc cctggggcta ttttgacttc     1080

aacagattcc actgccactt ctcatcacgt gactggcagc gactcatcaa caacaactgg     1140

ggattccggc ccaagagact caacttcaag ctcttcaaca tccaggtcaa ggaggtcacg     1200

cagaatgaag gcaccaagac catcgccaat aaccttacca gcacgattca ggtctttacg     1260

gactcggaat accggctccc gtacgtcctc ggctctgcgc accagggctg cctgcctccg     1320

ttcccggcgg acgtcttcat gattcctcag tacgggtacc tgactctgaa caacggcagt     1380

caggccgtgg gccgttcctc cttctactgc ctggagtact ttccttctca aatgctgaga     1440

acgggcaaca actttgagtt cagctaccag tttgaggacg tgccttttca cagcagctac     1500

gcgcacagcc aaagcctgga ccggctgatg aaccccctca tcgaccagta cctgtactac     1560

ctgtctcgga ctcagtccac gggaggtacc gcaggaactc agcagttgct attttctcag     1620

gccgggccta ataacatgtc ggctcaggcc aaaaactggc tacccgggcc ctgctaccgg     1680

cagcaacgcg tctccacgac actgtcgcaa aataacaaca gcaactttgc ttggaccggt     1740

gccaccaagt atcatctgaa tggcagagac tctctggtaa atcccggtgt cgctatggca     1800

acgcacaagg acgacgaaga gcgatttttt ccatccagcg gagtcttgat gtttgggaaa     1860

cagggagctg gaaaagacaa cgtggactat agcagcgtta tgctaaccag tgaggaagaa     1920

atcaaaacca ccaacccagt ggccacagaa cagtacggcg tggtggccga taacctgcaa     1980

cagcaaaacg ccgctcctat tgtaggggcc gtcaacagtc aaggagcctt acctggcatg     2040

gtctggcaga accgggacgt gtacctgcag ggtcctatct gggccaagat tcctcacacg     2100

gacggcaact ttcatccttc gccgctgatg ggaggctttg gactgaaaca cccgcctcct     2160

cagatcctga ttaagaatac acctgttccc gcggatcctc caactacctt cagtcaagcc     2220

aagccggcgt cgttcatcac gcagtacagc accggacagg tcagcgtgga aattgaatgg     2280

gagctgcaga aagagaacag caagcgctgg aacccagaga ttcagtatac ttccaactac     2340

tacaaatcta caaatgtgga ctttgctgtc aatactgagg gtacttattc agagcctcgc     2400

cccattggca cccgttacct cacccgtaac ctgtaattgc ctgttaatca ataaaccggt     2460

taattcgttt cagttgaact ttggtctctg cgaagggcga attc                      2504


<210>  67
<211>  731
<212>  PRT
<213>  Adeno-associated virus

<400>  67

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Gly Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Ser Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Thr Asp Ser Glu Tyr Arg Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Gln Phe Glu Asp Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Ser Thr Gly 
        435                 440                 445             


Gly Thr Ala Gly Thr Gln Gln Leu Leu Phe Ser Gln Ala Gly Pro Asn 
    450                 455                 460                 


Asn Met Ser Ala Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg 
465                 470                 475                 480 


Gln Gln Arg Val Ser Thr Thr Leu Ser Gln Asn Asn Asn Ser Asn Phe 
                485                 490                 495     


Ala Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asp Ser Leu 
            500                 505                 510         


Val Asn Pro Gly Val Ala Met Ala Thr His Lys Asp Asp Glu Glu Arg 
        515                 520                 525             


Phe Phe Pro Ser Ser Gly Val Leu Met Phe Gly Lys Gln Gly Ala Gly 
    530                 535                 540                 


Lys Asp Asn Val Asp Tyr Ser Ser Val Met Leu Thr Ser Glu Glu Glu 
545                 550                 555                 560 


Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val Val Ala 
                565                 570                 575     


Asp Asn Leu Gln Gln Gln Asn Ala Ala Pro Ile Val Gly Ala Val Asn 
            580                 585                 590         


Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr 
        595                 600                 605             


Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe 
    610                 615                 620                 


His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro 
625                 630                 635                 640 


Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Thr 
                645                 650                 655     


Phe Ser Gln Ala Lys Pro Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly 
            660                 665                 670         


Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys 
        675                 680                 685             


Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Thr 
    690                 695                 700                 


Asn Val Asp Phe Ala Val Asn Thr Glu Gly Thr Tyr Ser Glu Pro Arg 
705                 710                 715                 720 


Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730     


<210>  68
<211>  3128
<212>  DNA
<213>  Adeno-associated virus

<400>  68
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcttccg      180

cccagatcga tcccaccccc gtgatcgtca cttccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttaca agaccggatg ttcaaatttg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac aaagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

agacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgccattcat catctgctag ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaggcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc cgacgccgag     1140

tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagaccggt agagccatca ccccagcgtt ctccagactc ctctacgggc     1320

atcggcaaga caggccagca gcccgcgaaa aagagactca actttgggca gactggcgac     1380

tcagagtcag tgcccgaccc tcaaccaatc ggagaacccc ccgcaggccc ctctggtctg     1440

ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa cgaaggcgcc     1500

gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct gggcgacaga     1560

gtcatcacca ccagcacccg aacctgggcc ctccccacct acaacaacca cctctacaag     1620

caaatctcca acgggacatc gggaggaagc accaacgaca acacctactt cggctacagc     1680

accccctggg ggtattttga ctttaacaga ttccactgcc acttctcacc acgtgactgg     1740

cagcgactca tcaacaacaa ctggggattc cggcccaaga gactcaactt caagctcttc     1800

aacatccagg tcaaggaggt cacgcagaat gaaggcacca agaccatcgc caataacctt     1860

accagcacga ttcaggtctt tacggactcg gaataccagc tcccgtacgt cctcggctct     1920

gcgcaccagg gctgcctgcc tccgttcccg gcggacgtct tcatgattcc tcagtacggg     1980

tacctgactc tgaacaacgg cagtcaggcc gtgggccgtt cctccttcta ctgcctggag     2040

tactttcctt ctcaaatgct gagaacgggc aacaactttg agttcagcta ccagtttgag     2100

gacgtgcctt ttcacagcag ctacgcgcac agccaaagcc tggaccggct gatgaacccc     2160

ctcatcgacc agtacctgta ctacctgtct cggactcagt ccacgggagg taccgcagga     2220

actcagcagt tgctattttc tcaggccggg cctaataaca tgtcggctca ggccaaaaac     2280

tggctacccg ggccctgcta ccggcagcaa cgcgtctcca cgacactgtc gcaaaataac     2340

aacagcaact ttgcttggac cggtgccacc aagtatcatc tgaatggcag agactctctg     2400

gtaaatcccg gtgtcgctat ggcaacgcac aaggacgacg aagagcgatt ttttccatcc     2460

agcggagtct tgatgtttgg gaaacaggga gctggaaaag acaacgtgga ctatagcagc     2520

gttatgctaa ccagtgagga agaaatcaaa accaccaacc cagtggccac agaacagtac     2580

ggcgtggtgg ccgataacct gcaacagcaa aacgccgctc ctattgtagg ggccgtcaac     2640

agtcaaggag ccttacctgg catggtctgg cagaaccggg acgtgtacct gcagggtcct     2700

atctgggcca agattcctca cacggacggc aactttcatc cttcgccgct gatgggaggc     2760

tttggactga aacacccgcc tcctcagatc ctgattaaga atacacctgt tcccgcggat     2820

cctccaacta ccttcagtca agccaagctg gcgtcgttca tcacgcagta cagcaccgga     2880

caggtcagcg tggaaattga atgggagctg cagaaagaga acagcaagcg ctggaaccca     2940

gagattcagt atacttccaa ctactacaaa tctacaaatg tggactttgc tgtcaatact     3000

gagggtactt attcagagcc tcgccccatt ggcacccgtt acctcacccg taacctgtaa     3060

ttgcctgtta atcaataaac cggctaattc gtttcagttg aactttggtc tctgcgaagg     3120

gcgaattc                                                              3128


<210>  69
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  69

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  70
<211>  3084
<212>  DNA
<213>  Adeno-associated virus

<400>  70
gaattcgccc tttctacggc tgcatcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcgtccg      180

cccagatcga ccccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttgca ggaccggatg ttcaagttcg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac caagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gcggagccag caaaagaccc gcccccgatg acgcggatat aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

aaacgtgcga gaaaatgaat cagaatttca acatttgctt cacgcacggg gtcagagact      660

gctcagaatg tttccccggt gcatcagaat ctcaaccggt cgtcagaaaa aaaacgtatc      720

agaaactgtg tgccattcat catctgctgg ggcgggcacc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggacgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggcttgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacctgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaggcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc cgacgccgag     1140

tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagaccggt agagccatca cctcagcgtt cccccgactc ctccacgggc     1320

atcggcaaga aaggccacca gcccgcgaga aagagactga actttgggca gactggcgac     1380

tcggagtcag tccccgaccc tcaaccaatc ggagaaccac cagcaggccc ctctggtctg     1440

ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa cgaaggcgcc     1500

gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct gggcgacaga     1560

gtcatcacca ccagcacccg aacctgggcc ctgcccacct acaacaacca tctctacaag     1620

caaatctcca acgggacatc gggaggaagc actaacgaca acacctactt tggctacagc     1680

accccctggg ggtattttga cttcaacaga ttccactgcc acttctcacc acgtgactgg     1740

cagcgactca tcaacaataa ctggggattc cggcccaaga gactcaactt caagctcttc     1800

aacatccagg tcaaggaggt cacgcagaat gaaggcacca agaccatcgc caataacctt     1860

accagcacga ttcaggtgtt tacggactcg gaataccagc tcccgtacgt ccccggctct     1920

gcgcaccagg gctgcctccc tccgttcccg gcggacgtct tcatgattcc tcagtacggg     1980

tatctgaccc taaacaatgg cagtcaggct gtgggccgtt cctccttcta ctgcctggaa     2040

tacttccctt ctcaaatgct gaggacgggc aacaactttg aattcagcta caccttcgag     2100

gacgtgcctt tccacagcag ctacgcgcac agccagagcc tggaccggct gatgaaccct     2160

ctcatcgacc agtacctgta ttacttatcc agaactcagt ccacaggagg aactcaaggt     2220

actcagcaat tgttattttc tcaagccggg cccgcaaaca tgtcggctca ggccaagaac     2280

tggctacctg gaccgtgtta ccgtcagcaa cgagtttcca cgacactgtc gcaaaacaac     2340

aacagcaatt ttgcttggac cggtgccacc aagtatcacc tgaatggcag agactccctg     2400

gttaatcccg gcgttgccat ggctacccac aaggacgacg aggagcgctt cttcccgtca     2460

agcggagttc taatgtttgg caagcagggg gctggaaaag acaatgtgga ctacagcagc     2520

gtgatgctca ccagcgaaga agaaattaaa actactaacc cagtggctac agagcagtat     2580

ggtgtggtgg cagacaacct gcagcagacc aacggagctc ccattgtggg aactgtcaac     2640

agccaggggg ccttacctgg tatggtctgg caaaaccggg acgtgtacct gcagggcccc     2700

atctgggcca aaattcctca cacggacggc aactttcatc cttcgccgct gatgggaggc     2760

tttggactga aacacccgcc tcctcagatc ctggtgaaaa acactcctgt tcctgcggat     2820

cctccgacca ccttcagcca ggccaagctg gcttctttta tcacgcagta cagcaccgga     2880

caggtcagcg tggaaatcga atgggagctg cagaaagaaa acagcaagcg ctggaaccca     2940

gagattcagt atacttccaa ctactacaaa tctacaaatg tggactttgc tgtcaatact     3000

gagggtactt attcagagcc tcgccccatt ggcactcgtt atctcacccg taatctgtaa     3060

ttgcttgtta atcaataaac cggt                                            3084


<210>  71
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  71

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Pro Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Gly Ala 
            580                 585                 590         


Pro Ile Val Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Val Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  72
<211>  3123
<212>  DNA
<213>  Adeno-associated virus

<400>  72
gaattcgccc ttggctgcgt caactggacc aatgagaact ttcccttcaa cgattgcgtc       60

gacaagatgg tgatctggtg ggaggagggc aagatgacgg ccaaggtcgt ggagtccgcc      120

aaggccattc tcggcggcag caaggtgcgc gtggaccaaa agtgcaagtc gtccgcccag      180

atcgacccca cccccgtgat cgtcacctcc aacaccaaca tgtgcgccgt gattgacggg      240

aacagcacca ccttcgagca ccagcagccg ttgcaggacc ggatgttcaa gttcgaactc      300

acccgccgtc tggagcacga ctttggcaag gtgaccaagc aggaagtcaa agagttcttc      360

cgctgggcgc aggatcacgt gaccgaggtg gcgcatgagt tctacgtcag aaagggcgga      420

gccagcaaaa gacccgcccc cgatgacgcg gatataagcg agcccaagcg ggcctgcccc      480

tcagtcgcgg atccatcgac gtcagacgcg gaaggagctc cggtggactt tgccgacagg      540

taccaaaaca aatgttctcg tcacgcgggc atgctccaga tgctgtttcc ctgcaaaacg      600

tgcgagagaa tgaatcagaa tttcaacatt tgcttcacgc acggggtcag agactgctca      660

gaatgtttcc ccggtgcatc agaatctcaa ccggtcgtca gaaaaaaaac gtatcagaaa      720

ctgtgtgcca ttcatcatct gctggggcgg gcacccgaga ttgcttgctc ggcctgcgat      780

ctggtcaacg tggacctgga cgactgtgtt tctgagcaat aaatgactta aaccaggtat      840

ggctgccgat ggttatcttc cagattggct tgaggacaac ctctctgagg gcattcgcga      900

gtggtgggac ctgaaacctg gagccccgaa acccaaagcc aaccagcaaa agcaggacga      960

cggccggggt ctggtgcttc ctggctacaa gtacctcgga cccttcaacg gactcgacaa     1020

gggggagccc gtcaacgcgg cggacgcagc ggccctcgag cacgacaagg cctacgacca     1080

gcagctcaaa gcgggtgaca atccgtacct gcggtataac cacgccgacg ccgagtttca     1140

ggagcgtctg caagaagata cgtcttttgg gggcaacctc gggcgagcag tcttccaggc     1200

caagaagcgg gttctcgaac ctctcggtct ggttgaggaa ggcgctaaga cggctcctgg     1260

aaagaagaga ccggtagagc catcacctca gcgttccccc gactcctcca cgggcatcgg     1320

caagaaaggc caccagcccg cgagaaagag actgaacttt gggcagactg gcgactcgga     1380

gtcagtcccc gaccctcaac caatcggaga accaccagca ggcccctctg gtctgggatc     1440

tggtacaatg gctgcaggcg gtggcgctcc aatggcagac aataacgaag gcgccgacgg     1500

agtgggtagt tcctcaggaa attggcattg cgattccaca tggctgggcg acagagtcat     1560

caccaccagc acccgaacct gggccctgcc cacctacaac aaccatctct acaagcaaat     1620

ctccaacggg acatcgggag gaagcactaa cgacaacacc tactttggct acagcacccc     1680

ctgggggtat tttgacttca acagattcca ctgccacttc tcaccacgtg actggcagcg     1740

actcatcaac aataactggg gattccggcc caagagactc aacttcaagc tcttcaacat     1800

ccaggtcaag gaggtcacgc agaatgaagg caccaagacc atcgccaata accttaccag     1860

cacgattcag gtgtttacgg actcggaata ccagctcccg tacgtcctcg gctctgcgca     1920

ccagggctgc ctccctccgt tcccggcgga cgtcttcatg attcctcagt acgggtatct     1980

gaccctaaac aatggcagtc aggctgtggg ccgttcctcc ttctactgcc tggaatactt     2040

cccttctcaa atgctgagga cgggcaacaa ctttgaattc agctacacct tcgaggacgt     2100

gcctttccac agcagctacg cgcacagcca gagcctggac cggctgatga accctctcat     2160

cgaccagtac ctgtattact tatccagaac tcagtccaca ggaggaactc aaggtactca     2220

gcaattgtta ttttctcaag ccgggcccgc aaacatgtcg gctcaggcca agaactggct     2280

acctggaccg tgttaccgtc agcaacgagt ttccacgaca ctgtcgcaaa acaacaacag     2340

caattttgct tggaccggtg ccaccaagta tcacctgaat ggcagagact ccctggttaa     2400

tcccggcgtt gccatggcta cccacaagga cgacgaggag cgcttcttcc cgtcaagcgg     2460

agttctaatg tttggcaagc agggggctgg aaaagacaat gtggactaca gcagcgtgat     2520

gctcaccagc gaagaagaaa ttaaaactac taacccagtg gctacagagc agtatggtgt     2580

ggtggcagac aacctgcagc agaccaacgg agctcccatt gtgggaactg tcaacagcca     2640

gggggcctta cctggtatgg tctggcaaaa ccgggacgtg tacctgcagg gccccatctg     2700

ggccaaaatt cctcacacgg acggcaactt tcatccttcg ccgctgatgg gaggctttgg     2760

actgaaacac ccgcctcctc agatcctggt gaaaaacact cctgttcctg cggatcctcc     2820

gaccaccttc agccaggcca agctggcttc ttttatcacg cagtacagca ccggacaggt     2880

cagcgtggaa atcgaatggg agctgcagaa agaaaacagc aagcgctgga acccagagat     2940

tcagtatact tccaactact acaaatctac aaatgtggac tttgctgtca atactgaggg     3000

tacttattca gagcctcgcc ccattggcac tcgttatctc acccgtaatc tgtaattgct     3060

tgttaatcaa taaaccggtt aattcgtttc agttgaactt tggtctctgc gaagggcgaa     3120

ttc                                                                   3123


<210>  73
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  73

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Gly Ala 
            580                 585                 590         


Pro Ile Val Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Val Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  74
<211>  3122
<212>  DNA
<213>  Adeno-associated virus

<400>  74
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgtgtgga ccaaaagtgc aagtcttccg      180

cccagatcga tcccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag cgccaccttc gagcaccagc agccgttgca ggaccggatg ttcaaatttg      300

aactcacccg ccgtctggag catgactttg gcaaggtgac gaagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttccac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggatat aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

agacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgcgattcat catctgctgg ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaagcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataatcacgc cgacgccgag     1140

tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagactggt agagcagtcg ccacaagagc cagactcctc ctcgggcatc     1320

ggcaagacag gccagcagcc cgctaaaaag agactcaatt ttggtcagac tggcgactca     1380

gagtcagtcc ccgacccaca acctctcgga gaacctccag cagccccctc aggtctggga     1440

cctaatacaa tggcttcagg cggtggcgct ccaatggcag acaataacga aggcgccgac     1500

ggagtgggta attcctcggg aaattggcat tgcgattcca catggctggg ggacagagtc     1560

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa     1620

atctccaacg gcacctcggg aggaagcacc aacgacaaca cctattttgg ctacagcacc     1680

ccctgggggt attttgactt caacagattc cactgtcact tttcaccacg tgactggcaa     1740

cgactcatca acaacaattg gggattccgg cccaaaagac tcaacttcaa gctgttcaac     1800

atccaggtca aggaagtcac gacgaacgaa ggcaccaaga ccatcgccaa taatctcacc     1860

agcaccgtgc aggtctttac ggactcggag taccagttac cgtacgtgct aggatccgct     1920

caccagggat gtctgcctcc gttcccggcg gacgtcttca cggttcctca gtacggctat     1980

ttaactttaa acaatggaag ccaagccctg ggacgttcct ccttctactg tctggagtat     2040

ttcccatcgc agatgctgag aaccggcaac aactttcagt tcagctacac cttcgaggac     2100

gtgcctttcc acagcagcta cgcgcacagc cagagcctgg acaggctgat gaatcccctc     2160

atcgaccagt acctgtacta cctggtcaga acgcaaacga ctggaactgg agggacgcag     2220

actctggcat tcagccaagc gggtcctagc tcaatggcca accaggctag aaattgggtg     2280

cccggacctt gctaccggca gcagcgcgtc tccacgacaa ccaaccagaa caacaacagc     2340

aactttgcct ggacgggagc tgccaagttt aagctgaacg gccgagactc tctaatgaat     2400

ccgggcgtgg caatggcttc ccacaaggat gacgacgacc gcttcttccc ttcgagcggg     2460

gtcctgattt ttggcaagca aggagccggg aacgatggag tggattacag ccaagtgctg     2520

attacagatg aggaagaaat caaggctacc aaccccgtgg ccacagaaga atatggagca     2580

gtggccatca acaaccaggc cgccaatacg caggcgcaga ccggactcgt gcacaaccag     2640

ggggtgattc ccggcatggt gtggcagaat agagacgtgt acctgcaggg tcccatctgg     2700

gccaaaattc ctcacacgga cggcaacttt cacccgtctc ccctgatggg cggctttgga     2760

ctgaagcacc cgcctcctca aattctcatc aagaacacac cggttccagc ggacccgccg     2820

cttaccttca accaggccaa gctgaactct ttcatcacgc agtacagcac cggacaggtc     2880

agcgtggaaa tcgagtggga gctgcagaaa gaaaacagca aacgctggaa tccagagatt     2940

caatacactt ccaactacta caaatctaca aatgtggact ttgctgtcaa cacggaagga     3000

gtttatagcg agcctcgccc cattggcacc cgttacctca cccgcaacct gtaattacat     3060

gttaatcaat aaaccggtta attcgtttca gttgaacttt ggtctctgcg aagggcgaat     3120

tc                                                                    3122


<210>  75
<211>  736
<212>  PRT
<213>  Adeno-associated virus

<400>  75

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Leu Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Thr Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Asp Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  76
<211>  3117
<212>  DNA
<213>  Adeno-associated virus

<400>  76
gaattcgccc ttggctgcgt caactggacc aatgagaact ttcccttcaa cgattgcgtc       60

gacaagatgg tgatctggtg ggaggagggc aagatgacgg ccaaggtcgt ggagtccgcc      120

aaggccattc tcggcggcag caaggtgcgt gtggaccaaa agtgcaagtc ttccgcccag      180

atcgatccca cccccgtgat cgtcacctcc aacaccaaca tgtgcgccgt gattgacggg      240

aacagcacca ccttcgagca ccagcagccg ttgcaggacc ggatgttcaa atttgaactc      300

acccgccgtc tggagcatga ctttggcaag gtgacgaagc aggaagtcaa agagttcttc      360

cgctgggcgc aggatcacgt gaccgaggtg gcgcatgagt tccacgtcag aaagggtgga      420

gccaacaaga gacccgcccc cgatgacgcg gatataagcg agcccaagcg ggcctgcccc      480

tcagtcgcgg atccatcgac gtcagacgcg gaaggagctc cggtggactt tgccgacagg      540

taccaaaaca aatgttctcg tcacgcgggc atgcttcaga tgctgtttcc ctgcaagaca      600

tgcgagagaa tgaatcagaa tttcaacatt tgcttcacgc acgggaccag agactgttca      660

gaatgtttcc ccggcgtgtc agaatctcaa ccggtcgtca gaaagaggac gtatcggaaa      720

ctctgtgcga ttcatcatct gctggggcgg gctcccgaga ttgcttgctc ggcctgcgat      780

ctggtcaacg tggacctgga tgactgtgtt tctgagcaat aaatgactta aaccaggtat      840

ggctgccgat ggttatcttc cagattggct cgaggacaac ctctctgagg gcattcgcga      900

gtggtgggac ttgaaacctg gagccccgaa acccaaagcc aaccagcaaa agcaggacga      960

cggccggggt ctggtgcttc ctggctacaa gtacctcgga cccttcaacg gactcgacaa     1020

gggggagccc gtcaacgcgg cggacgcagc ggccctcgag cacgacaaag cctacgacca     1080

gcagctcaaa gcgggtgaca atccgtacct gcggtataat cacgccgacg ccgagtttca     1140

ggagcgtctg caagaagata cgtcttttgg gggcaacctc gggcgagcag tcttccaggc     1200

caagaagcgg gttctcgaac ctctcggtct ggttgaggaa ggcgctaaga cggctcctgg     1260

aaagaagaga ccggtagagc agtcgccaca agagccagac tcctcctcgg gcatcggcaa     1320

gacaggccag cagcccgcta aaaagagact caattttggt cagactggcg actcagagtc     1380

agtccccgac ccacaacctc tcggagaacc tccagcagcc ccctcaggtc tgggacctaa     1440

tacaatggct tcaggcggtg gcgctccaat ggcagacaat aacgaaggcg ccgacggagt     1500

gggtaattcc tcgggaaatt ggcattgcga ttccacatgg ctgggggaca gagtcatcac     1560

caccagcacc cgaacctggg ccctgcccac ctacaacaac cacctctaca agcaaatctc     1620

caacggcacc tcgggaggaa gcaccaacga caacacctat tttggctaca gcaccccctg     1680

ggggtatttt gacttcaaca gattccactg tcacttttca ccacgtgact ggcaacgact     1740

catcaacaac aattggggat tccggcccaa aagactcaac ttcaagctgt tcaacatcca     1800

ggtcaaggaa gtcacgacga acgaaggcac caagaccatc gccaataatc tcaccagcac     1860

cgtgcgggtc tttacggact cggagtacca gttaccgtac gtgctaggat ccgctcacca     1920

gggatgtctg cctccgttcc cggcggacgt cttcatggtt cctcagtacg gctatttaac     1980

tttaaacaat ggaagccaag ccctgggacg ttcctccttc tactgtctgg agtatttccc     2040

atcgcagatg ctgagaaccg gcaacaactt tcagttcagc tacaccttcg aggacgtgcc     2100

tttccacagc agctacgcgc acagccagag cctggacagg ctgatgaatc ccctcatcga     2160

ccagtacctg tactacctgg tcagaacgca aacgactgga actggaggga cgcagactct     2220

ggcattcagc caagcgggtc ctagctcaat ggccaaccag gctagaaatt gggtgcccgg     2280

accttgctac cggcagcagc gcgtctccac gacaaccaac cagagcaaca acagcaactt     2340

tgcctggacg ggagctgcca agtttaagct gaacggccga gactctctaa tgaatccggg     2400

cgtggcaatg gcttcccaca aggatgacga cgaccgcttc ttcccttcga gcggggtcct     2460

gatttttggc aagcaaggag ccgggaacga tggagtggat tacagccaag tgctgattac     2520

agatgaggaa gaaatcaagg ctaccaaccc cgtggccaca gaagaatatg gagcagtggc     2580

catcaacaac caggccgcca atacgcaggc gcagaccgga ctcgtgcaca accagggggt     2640

gattcccggc atggtgtggc agaatagaga cgtgtacctg cagggtccca tctgggccaa     2700

aattcctcac acggacggca actttcaccc gtctcccctg atgggcggct ttggactgaa     2760

gcacccgcct cctcaaattc tcatcaagaa cacaccggtt ccagcggacc cgccgcttac     2820

cttcaaccag gccaagctga actctttcat cacgcagtac agcaccggac aggtcagcgt     2880

ggaaatcgag tgggagctgc agaaagaaaa cagcaaacgc tggaatccag agattcaata     2940

cacttccaac tactacaaat ctacaaatgt ggactttgct gtcaacacgg aaggagttta     3000

tagcgagcct cgccccattg gcacccgtta cctcacccgc aacctgtaat tacatgttaa     3060

tcaataaacc ggttaattcg tttcagttga actttggtct ctgcgaaggg cgaattc        3117


<210>  77
<211>  736
<212>  PRT
<213>  Adeno-associated virus

<400>  77

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Arg Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Ser 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Asp Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  78
<211>  3121
<212>  DNA
<213>  Adeno-associated virus

<400>  78
gaattcgccc ttctacggct gcgtcaactg gaccaatgag aactttccct tcaacgattg       60

cgtcgacaag atggtgatct ggtgggagga gggcaagatg acggccaagg tcgtggagtc      120

cgccaaggcc attctcggcg gcagcaaggt gcgtgtggac caaaagtgca agtcttccgc      180

ccagatcgat cccacccccg tgatcgtcac ctccaacacc aacatgtgcg ccgtgattga      240

cgggaacagc accaccttcg agcaccagca gccgttgcag gaccggatgt tcaaatttga      300

actcacccgc cgtctggagc atgactttgg caaggtgacg aagcaggaag tcaaagagtt      360

cttccgctgg gcgcaggatc acgtgaccga ggtggcgcat gagttccacg tcagaaaggg      420

tggcgccaac aagagacccg cccccgatga cgcggatata agcgagccca agcgggcctg      480

cccctcagtc gcggatccat cgacgtcaga cgcggaagga gctccggtgg actttgccga      540

caggtaccaa aacaaatgtt ctcgtcacgc gggcatgctt cagatgctgt ttccctgcaa      600

gacatgcgag agaatgaatc agaatttcaa catttgcttc acgcacggga ccagagactg      660

ttcagaatgt ttccccggcg tgtcagaatc tcaaccggtc gtcagaaaga ggacgtatcg      720

gaaactctgt gcgattcatc atctgctggg gcgggctccc gagattgctt gctcggcctg      780

cgatctggtc aacgtggacc tggatgactg tgtttctgag caataaatga cttaaaccag      840

gtatggctgc cgatggttat cttccagatt ggctcgagga caacctctct gagggcattc      900

gcgagtggtg ggacttgaaa cctggagccc cgaaacccaa agccaaccag caaaagcagg      960

acgacggccg gggtctggtg cttcctggct acaagtacct cggacccttc aacggactcg     1020

acaaggggga gcccgtcaac gcggcggacg cagcggccct cgagcacgac aaagcctacg     1080

accagcagct caaagcgggt gacaatccgt acctgcggta taatcacgcc gacgccgagt     1140

ttcaggagcg tctgcaagaa gatacgtcct ttgggggcaa cctcgggcga gcagtcttcc     1200

aggccaagaa gcgggttctc gaacctctcg gtctggttga ggaaggcgct aagacggctc     1260

ctggaaagaa gagaccggta gagcagtcgc cacaagagcc agactcctcc tcgggcatcg     1320

gcaagacagg ccagcagccc gctaaaaaga gactcaattt tggtcagact ggcgactcag     1380

agtcagtccc cgacccacaa cctctcggag aacctccagc agccccctca ggtctgggac     1440

ctaatacaat ggcttcaggc ggtggcgctc caatggcaga caataacgaa ggcgccgacg     1500

gagtgggtaa ttcctcggga aattggcatt gcgattccac atggctgggg gacagagtca     1560

tcaccaccag cacccgaacc tgggccctgc ccacctacaa caaccacctc tacaagcaaa     1620

tctccaacgg cacctcggga ggaagcacca acgacaacac ctattttggc tacagcaccc     1680

cctgggggta ttttgacttc aacagattcc actgtcactt ttcaccacgt gactggcaac     1740

gactcatcaa caacaattgg ggattccggc ccaaaagact caacttcaag ctgttcaaca     1800

tccaggtcaa ggaagtcacg acgaacgaag gcaccaagac catcgccaat aatctcacca     1860

gcaccgtgca ggtctttacg gacttggagt accagttacc gtacgtgcta ggatccgctc     1920

accagggatg tctgcctccg ttcccggcgg acgtcttcat ggttcctcag tacggctatt     1980

taactttaaa caatggaagc caagccctgg gacgttcctc cttctactgt ctggagtatt     2040

tcccatcgca gatgccgaga accggcaaca actttcagtt cagctacacc ttcgaggacg     2100

tgcctttcca cagcagctac gcgcacagcc agagcctgga caggctgatg aatcccctca     2160

tcgaccagta cctgtactac ctggtcagaa cgcaaacgac tggaactgga gggacgcaga     2220

ctctggcatt cagccaagcg ggtcctagct caatggccaa ccaggctaga aattgggtgc     2280

ccggaccttg ctaccggcag cagcgcgtct ccacgacaac caaccagaac aacaacagca     2340

actttgcctg gacgggagct gccaagttta agctgaacgg ccgagactct ctaatgaatc     2400

cgggcgtggc aatggcttcc cacaaggatg acgacgaccg cttcttccct tcgagcgggg     2460

tcctgatttt tggcaagcaa ggagccggga acgatggagt ggattacagc caagtgctga     2520

ttacagatga ggaagaaatc aaggctacca accccgtggc cacagaagaa tatggagcag     2580

tggccatcaa caaccaggcc gccaatacgc aggcgcagac cggactcgtg cacaaccagg     2640

gggtgattcc cggcatggtg tggcagaata gagacgtgta cctgcagggt cccatctggg     2700

ccaaaattcc tcacacggac ggcaactttc acccgtctcc cctgatgggc ggctttggac     2760

tgaagcaccc gcctcctcaa attctcatca agaacacacc ggttccagcg gacccgccgc     2820

ttaccttcaa ccaggccaag ctgaactctt tcatcacgca gtacagcacc ggacaggtca     2880

gcgtggaaat cgagtgggag ctgcagaaag aaaacagcaa acgctggaat ccagagattc     2940

aatacacttc caactactac aaatctacaa atgtggactt tgctgtcaac acggaaggag     3000

tttatagcga gcctcgcccc attggcaccc gttacctcac ccgcaacctg taattacatg     3060

ttaatcaata aaccggttaa ttcgtttcag ttgaactttg gtctctgcga agggcgaatt     3120

c                                                                     3121


<210>  79
<211>  736
<212>  PRT
<213>  Adeno-associated virus

<400>  79

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Leu Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Pro Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Asp Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  80
<211>  3122
<212>  DNA
<213>  Adeno-associated virus

<400>  80
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgtgtgga ccaaaagtgc aagtcttccg      180

cccagatcga tcccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttgca ggaccggatg ttcaaatttg      300

aactcacccg ccgtctggag catgactttg gcaaggtgac gaagcaggaa gtcaaagggt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttccac gtgcgagccc      420

aagcgggcct gcccctcagt cgcggatcca tcgacgtcag accagaaagg gtggagccaa      480

caagagaccc gcccccgatg acgcggatat aagcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

agacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgcgattcat catctgctgg ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaagcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataatcacgc cgacgccgag     1140

tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagaccggt agagcagtcg ccacaagagc cagactcctc ctcgggcatc     1320

ggcaagacag gccagcagcc cgctaaaaag agactcaatt ttggtcagac tggcgactca     1380

gagtcagtcc ccgacccaca acctctcgga gaacctccag cagccccctc aggtctggga     1440

cctaatacaa tggcttcagg cggtggcgct ccaatggcag acaataacga aggcgccgac     1500

ggagtgggta attcctcggg aaattggcat tgcgattcca catggctggg ggacagagtc     1560

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa     1620

atctccaacg gcacctcggg aggaagcacc aacgacaaca cctattttgg ctacagcacc     1680

ccctgggggt attttgactt caacagattc cactgtcact tttcaccacg tgactggcaa     1740

cgactcatca acaacaattg gggattccgg cccaaaagac tcaacttcaa gctgttcaac     1800

atccaggtca aggaagtcac gacgaacgaa ggcaccaaga ccatcgccaa taatctcacc     1860

agcaccgtgc aggtctttac ggactcggag taccagttac cgtacgtgct aggatccgct     1920

caccagggat gtctgcctcc gttcccggcg gacgtcttca tggttcctca gtacggctat     1980

ttaactttaa acaatggaag ccaagccctg ggacgttcct ccttctactg tctggagtat     2040

ttcccatcgc agatgctgag aaccggcaac aactttcagt tcagctacac cttcgaggac     2100

gtgcctttcc acagcagcta cgcgcacagc cagagcctgg acaggctgat gaatcccctc     2160

atcgaccagt acctgtacta cctggtcaga acgcaaacga ctggaactgg agggacgcag     2220

actctggcat tcagccaagc gggtcctagc tcaatggcca accaggctag aaattgggtg     2280

cccggacctt gctaccggca gcagcgcgtc tccacgacaa ccaaccagaa caacaacagc     2340

aactttgcct ggacgggagc tgccaagttt aagctgaacg gccgagactc tctaatgaat     2400

ccgggcgtgg caatggcttc ccacaaggat gacgacgacc gcttcttccc ttcgagcggg     2460

gtcctgattt ttggcaagca aggagccggg aacgatggag tggattacag ccaagtgctg     2520

attacagatg aggaagaaat caaggctacc aaccccgtgg ccacagaaga atatggagca     2580

gtggccatca acaaccaggc cgccaatacg caggcgcaga ccggactcgt gcacaaccag     2640

ggggtgattc ccggcatggt gtggcagaat agagacgtgt acctgcaggg tcccatctgg     2700

gccaaaattc ctcacacgga cggcaacttt cacccgtctc ccctgatggg cggctttgga     2760

ctgaagcacc cgcctcctca aattctcatc aagaacacac cggttccagc ggacccgccg     2820

cttaccttca accaggccaa gctgaactct ttcatcacgc agtacagcac cggacaggtc     2880

agcgtggaaa tcgagtggga gctgcagaaa gaaaacagca aacgctggaa tccagagatt     2940

caatacactt ccaactacta caaatctaca aatgtggact ttgctgtcaa cacggagggg     3000

gtttatagcg agcctcgccc cattggcacc cgttacctca cccgcaacct gtaattacat     3060

gttaatcaat aaaccggtta attcgtttca gttgaacttt ggtctctgcg aagggcgaat     3120

tc                                                                    3122


<210>  81
<211>  736
<212>  PRT
<213>  Adeno-associated virus

<400>  81

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Asp Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  82
<211>  2370
<212>  DNA
<213>  Adeno-associated virus

<400>  82
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcgtccg      180

cccagatcga ccccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttgca ggaccggatg ttcaagttcg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac caagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gcggagccag caaaagaccc gcccccgatg acgcggatat aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagacgctg tttccctgca      600

aaacgtgcga gagaatgaat cagaatttca acatttgctt cacgcacggg gtcagagact      660

gctcagaatg tttccccggt gcatcagaat ctcaaccggt cgtcagaaaa aaaacgtatc      720

agaaactgtg tgccattcat catctgctgg ggcgggcacc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggacgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggcttgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacctgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaggcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc cgacgccgag     1140

tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagaccggt agagccatca cctcagcgtt cccccgactc ctccacgggc     1320

atcggcaaga aaggccacca gcccgcgaga aagagactga actttgggca gactggcgac     1380

tcggagtcag tccccgaccc tcaaccaatc ggagaaccac cagcaggccc ctctggtctg     1440

ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa cgaaggcgcc     1500

gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct gggcgacaga     1560

gtcatcacca ccagcacccg aacctgggcc ctgcccacct acaacaacca tctctacaag     1620

caaatctcca acgggacatc gggaggaagc actaacgaca acacctactt tggctacagc     1680

accccctggg ggtattttga cttcaacaga ttccactgcc acttctcacc acgtgactgg     1740

cagcgactca tcaacaataa ctggggattc cggcccaaga gactcaactt caagctcttc     1800

aacatccagg tcaaggaggt cacgcagaat gaaggcacca agaccatcgc caataacctt     1860

accagcacga ttcaggtgtt tacggactcg gaataccagc tcccgtacgt cctcggctct     1920

gcgcaccagg gctgcctccc tccgttcccg gcggacgtct tcatgattcc tcagtacggg     1980

tatctgaccc taaacaatgg cagtcaggct gtgggccgtt cctccttcta ctgcctggaa     2040

tacttccctt ctcaaatgct gaggacgggc aacaactttg aattcagcta caccttcgag     2100

gacgtgcctt tccacagcag ctacgcgcac agccagagcc tggaccggct gatgaaccct     2160

ctcatcgacc agtacctgta ttacttatcc agaactcagt ccacaggagg aactcaaggt     2220

actcagcaat tgttattttc tcaagccggg cccgcaaaca tgtyggctca ggccaagaac     2280

tggctacctg gaccgtgtta ccgtcagcaa cgagtttcca cgacactgtc gcaaaacaac     2340

aacagcaatt ttgctggacc ggtgccacca                                      2370


<210>  83
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  83

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Gly Ala 
            580                 585                 590         


Pro Ile Val Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Val Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  84
<211>  2205
<212>  DNA
<213>  Adeno-associated virus

<400>  84
atgactgacg gttaccttcc agattggcta gaggacaacc tctctgaagg cgttcgagag       60

tggtgggcgc tgcaacctgg agcccctaaa cccaaggcaa atcaacaaca tcaggacaac      120

gctcggggtc ttgtgcttcc gggttacaaa tacctcggac ccggcaacgg actcgacaag      180

ggggaacccg tcaacgcagc ggacgcggca gccctcgagc acgacaaggc ctacgaccag      240

cagctcaagg ccggtgacaa cccctacctc aagtacaacc acgccgacgc ggagttccag      300

cagcggcttc agggcgacac atcgtttggg ggcaacctcg gcagagcagt cttccaggcc      360

aaaaagaggg ttcttgaacc tcttggtctg gttgagcaag cgggtgagac ggctcctgga      420

aagaagagac cgttgattga atccccccag cagcccgact cctccacggg tatcggcaaa      480

aaaggcaagc agccggctaa aaagaagctc gttttcgaag acgaaactgg agcaggcgac      540

ggaccccctg agggatcaac ttccggagcc atgtctgatg acagtgagat gcgtgcagca      600

gctggcggag ctgcagtcga gggcggacaa ggtgccgatg gagtgggtaa tgcctcgggt      660

gattggcatt gcgattccac ctggtctgag ggccacgtca cgaccaccag caccagaacc      720

tgggtcttgc ccacctacaa caaccacctc tacaagcgac tcggagagag cctgcagtcc      780

aacacctaca acggattctc caccccctgg ggatactttg acttcaaccg cttccactgc      840

cacttctcac cacgtgactg gcagcgactc atcaacaaca actggggcat gcgacccaaa      900

gccatgcggg tcaaaatctt caacatccag gtcaaggagg tcacgacgtc gaacggcgag      960

acaacggtgg ctaataacct taccagcacg gttcagatct ttgcggactc gtcgtacgaa     1020

ctgccgtacg tgatggatgc gggtcaagag ggcagcctgc ctccttttcc caacgacgtc     1080

tttatggtgc cccagtacgg ctactgtgga ctggtgaccg gcaacacttc gcagcaacag     1140

actgacagaa atgccttcta ctgcctggag tactttcctt cgcagatgct gcggactggc     1200

aacaactttg aaattacgta cagttttgag aaggtgcctt tccactcgat gtacgcgcac     1260

agccagagcc tggaccggct gatgaaccct ctcatcgacc agtacctgtg gggactgcaa     1320

tcgaccacca ccggaaccac cctgaatgcc gggactgcca ccaccaactt taccaagctg     1380

cggcctacca acttttccaa ctttaaaaag aactggctgc ccgggccttc aatcaagcag     1440

cagggcttct caaagactgc caatcaaaac tacaagatcc ctgccaccgg gtcagacagt     1500

ctcatcaaat acgagacgca cagcactctg gacggaagat ggagtgccct gacccccgga     1560

cctccaatgg ccacggctgg acctgcggac agcaagttca gcaacagcca gctcatcttt     1620

gcggggccta aacagaacgg caacacggcc accgtacccg ggactctgat cttcacctct     1680

gaggaggagc tggcagccac caacgccacc gatacggaca tgtggggcaa cctacctggc     1740

ggtgaccaga gcaacagcaa cctgccgacc gtggacagac tgacagcctt gggagccgtg     1800

cctggaatgg tctggcaaaa cagagacatt tactaccagg gtcccatttg ggccaagatt     1860

cctcataccg atggacactt tcacccctca ccgctgattg gtgggtttgg gctgaaacac     1920

ccgcctcctc aaatttttat caagaacacc ccggtacctg cgaatcctgc aacgaccttc     1980

agctctactc cggtaaactc cttcattact cagtacagca ctggccaggt gtcggtgcag     2040

attgactggg agatccagaa ggagcggtcc aaacgctgga accccgaggt ccagtttacc     2100

tccaactacg gacagcaaaa ctctctgttg tgggctcccg atgcggctgg gaaatacact     2160

gagcctaggg ctatcggtac ccgctacctc acccaccacc tgtaa                     2205


<210>  85
<211>  734
<212>  PRT
<213>  Adeno-associated virus

<400>  85

Met Thr Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser Glu 
1               5                   10                  15      


Gly Val Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro Lys 
            20                  25                  30          


Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro Val 
    50                  55                  60                  


Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Gln 
65                  70                  75                  80  


Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Gln Arg Leu Gln Gly Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Gln Ala Gly Glu Thr Ala Pro Gly Lys Lys Arg Pro 
    130                 135                 140                 


Leu Ile Glu Ser Pro Gln Gln Pro Asp Ser Ser Thr Gly Ile Gly Lys 
145                 150                 155                 160 


Lys Gly Lys Gln Pro Ala Lys Lys Lys Leu Val Phe Glu Asp Glu Thr 
                165                 170                 175     


Gly Ala Gly Asp Gly Pro Pro Glu Gly Ser Thr Ser Gly Ala Met Ser 
            180                 185                 190         


Asp Asp Ser Glu Met Arg Ala Ala Ala Gly Gly Ala Ala Val Glu Gly 
        195                 200                 205             


Gly Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys 
    210                 215                 220                 


Asp Ser Thr Trp Ser Glu Gly His Val Thr Thr Thr Ser Thr Arg Thr 
225                 230                 235                 240 


Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Arg Leu Gly Glu 
                245                 250                 255     


Ser Leu Gln Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Asn Trp Gly Met Arg Pro Lys Ala Met Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu 
305                 310                 315                 320 


Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp 
                325                 330                 335     


Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser 
            340                 345                 350         


Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Cys Gly Leu Val Thr Gly Asn Thr Ser Gln Gln Gln Thr Asp Arg Asn 
    370                 375                 380                 


Ala Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly 
385                 390                 395                 400 


Asn Asn Phe Glu Ile Thr Tyr Ser Phe Glu Lys Val Pro Phe His Ser 
                405                 410                 415     


Met Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile 
            420                 425                 430         


Asp Gln Tyr Leu Trp Gly Leu Gln Ser Thr Thr Thr Gly Thr Thr Leu 
        435                 440                 445             


Asn Ala Gly Thr Ala Thr Thr Asn Phe Thr Lys Leu Arg Pro Thr Asn 
    450                 455                 460                 


Phe Ser Asn Phe Lys Lys Asn Trp Leu Pro Gly Pro Ser Ile Lys Gln 
465                 470                 475                 480 


Gln Gly Phe Ser Lys Thr Ala Asn Gln Asn Tyr Lys Ile Pro Ala Thr 
                485                 490                 495     


Gly Ser Asp Ser Leu Ile Lys Tyr Glu Thr His Ser Thr Leu Asp Gly 
            500                 505                 510         


Arg Trp Ser Ala Leu Thr Pro Gly Pro Pro Met Ala Thr Ala Gly Pro 
        515                 520                 525             


Ala Asp Ser Lys Phe Ser Asn Ser Gln Leu Ile Phe Ala Gly Pro Lys 
    530                 535                 540                 


Gln Asn Gly Asn Thr Ala Thr Val Pro Gly Thr Leu Ile Phe Thr Ser 
545                 550                 555                 560 


Glu Glu Glu Leu Ala Ala Thr Asn Ala Thr Asp Thr Asp Met Trp Gly 
                565                 570                 575     


Asn Leu Pro Gly Gly Asp Gln Ser Asn Ser Asn Leu Pro Thr Val Asp 
            580                 585                 590         


Arg Leu Thr Ala Leu Gly Ala Val Pro Gly Met Val Trp Gln Asn Arg 
        595                 600                 605             


Asp Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Ala Thr Thr Phe Ser Ser Thr Pro Val Asn Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Gln Ile Asp Trp Glu Ile Gln Lys Glu 
        675                 680                 685             


Arg Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly 
    690                 695                 700                 


Gln Gln Asn Ser Leu Leu Trp Ala Pro Asp Ala Ala Gly Lys Tyr Thr 
705                 710                 715                 720 


Glu Pro Arg Ala Ile Gly Thr Arg Tyr Leu Thr His His Leu 
                725                 730                 


<210>  86
<211>  3128
<212>  DNA
<213>  Adeno-associated virus

<400>  86
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatgttgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaaag tgcgcgtgga ccaaaagtgc aagccgtccg      180

cccagatcga ccccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttgcg ggaccggatg ttcaagtttg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac aaagcaggaa gtcagagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca cgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

aaacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaaa aagacgtatc      720

ggaaactctg tgcgattcat catctgctgg ggcgggcacc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctagatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaggcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc cgacgccgag     1140

tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagaccggt agagccatca ccccagcgtt ctccagactc ctctacgggc     1320

atcggcaaga aaggccagca gcccgcgaaa aagagactca actttgggca gactggcgac     1380

tcagagtcag tgcccgaccc tcaaccaatc ggagaacccc ccgcaggccc ctctggtctg     1440

ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa cgaaggcgcc     1500

gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct gggcgacaga     1560

gtcatcacca ccagcacccg aacctgggcc ctccccacct acaacaacca cctctacaag     1620

caaatctcca acgggacttc gggaggaagc accaacgaca acacctactt cggctacagc     1680

accccctggg ggtattttga ctttaacaga ttccactgcc acttctcacc acgtgactgg     1740

cagcgactca tcaacaacaa ctggggattc cggcccaaga gactcaactt caagctcttc     1800

aacatccagg tcaaggaggt cacgcagaat gaaggcacca agaccatcgc caataacctt     1860

accagcacga ttcaggtctt tacggactcg gaataccagc tcccgtacgt cctcggctct     1920

gcgcaccagg gctgcctgcc tccgttcccg gcggacgtct tcatgattcc tcagtacggg     1980

tacctgactc tgaacaatgg cagtcaggcc gtgggccgtt cctccttcta ctgcctggag     2040

tactttcctt ctcaaatgct gagaacgggc aacaactttg agttcagcta ccagtttgag     2100

gacgtgcctt ttcacagcag ctacgcgcac agccaaagcc tggaccggct gatgaacccc     2160

ctcatcgacc agtacctgta ctacctgtct cggactcagt ccacgggagg taccgcagga     2220

actcagcagt tgctattttc tcaggccggg cctaataaca tgtcggctca ggccaaaaac     2280

tggctacccg ggccctgcta ccggcagcaa cgcgtctcca cgacactgtc gcaaaataac     2340

aacagcaact gtaaatcccg gtgtcgctat ggcaacccac aaggacgacg aagagcgatt     2400

ttgcctggac cggtgccacc aagtatcatc tgaatggcag agactctctg ttttccgtcc     2460

agcggagtct taatgtttgg gaaacaggga gctggaaaag acaacgtgga ctatagcagc     2520

gttatgctaa ccagtgagga agaaattaaa accaccaacc cagtggccac ggaacagtac     2580

ggcgtggtgg ccgataacct gcaacagcaa aacgccgctc ctattgtagg ggccgtcaac     2640

agtcaaggag ccttacctgg catggtctgg cagaaccggg acgtgtacct gcagggtcct     2700

atctgggcca agattcctca cacggacgga aactttcatc cctcgccgct gatgggaggc     2760

tttggactga aacacccgcc tcctcagatc ctgattaaga atacacctgt tcccgcggat     2820

cctccaacta ccttcagtca agctaagctg gcgtcgttca tcacgcagta cagcaccgga     2880

caggtcagcg tggaaattga atgggagctg cagaaagaaa acagcaaacg ctggaaccca     2940

gagattcaat acacttccaa ctactacaaa tctacaaatg tggacttcgc tgttaacaca     3000

gatggcactt attctgagcc tcgccccatt ggcacccgtt acctcacccg taatctgtaa     3060

ttgctcgtta atcaataaac cggttgattc gtttcagttg aactttggtc tctgcgaagg     3120

gcgaattc                                                              3128


<210>  87
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  87

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Asp 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  88
<211>  3128
<212>  DNA
<213>  Adeno-associated virus

<400>  88
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaaag tgcgcgtgga ccaaaagtgc aagtcgtccg      180

cccagatcga ccccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttgca ggaccggatg ttcaagtttg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac aaagcaggaa gtcagagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca cgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

aaacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt tgtcagaaaa aagacgtatc      720

ggaaactctg tgcgattcat catctgctgg ggcgggcacc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctagatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaggcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc cgacgccgag     1140

tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagaccggt agagccatca ccccagcgtt ctccagactc ctctacgggc     1320

atcggcaaga aaggccagca gcccgcgaaa aagagactca actttgggca gactggcgac     1380

tcagagtcag tgcccgaccc tcaaccaatc ggagaacccc ccgcaggccc ctctggtctg     1440

ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa cgaaggcgcc     1500

gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct gggcgacaga     1560

gtcatcacca ccagcacccg aacctgggcc ctccccacct acaacaacca cctctacaag     1620

caaatctcca acgggacttc gggaggaagc accaacgaca acacctactt cggctacagc     1680

accccctggg ggtattttga ctttaacaga ttccactgcc acttctcacc acgtgactgg     1740

cagcgactca tcaacaacaa ctggggattc cggcccaaga gacccaactt caagctcttc     1800

aacatccagg tcaaggaggt cacgcagaat gaaggcacca agaccatcgc caataacctt     1860

accagcacga ttcaggtctt tacggactcg gaataccagc tcccgtacgt cctcggctct     1920

gcgcaccagg gctgcctgcc tccgttcccg gcggacgtct tcatgattcc tcagtacggg     1980

tacctgactc tgaacaatgg cagtcaggcc gtgggccgtt cctccttcta ctgcctggag     2040

tactttcctt ctcaaatgct gagaacgggc aacaactttg agttcagcta ccagtttgag     2100

gacgtgcctt ttcacagcag ctacgcgcac agccaaagcc tggaccggct gatgaacccc     2160

ctcatcgacc agtacctgta ctacctgtct cggactcagt ccacgggagg taccgcagga     2220

actcagcagt tgctattttc tcaggccggg cctaataaca tgtcggctca ggccaaaaac     2280

tggctacccg ggccctgcta ccggcagcaa cgcgtctcca cgacactgtc gcaaaataac     2340

aacagcaact ttgcctggac cggtgccacc aagtatcatc tgaatggcag agactctctg     2400

gtaaatcccg gtgtcgctat ggcaacccac aaggacgacg aagagcgatt ttttccgtcc     2460

agcggagtct taatgtttgg gaaacaggga gctggaaaag acaacgtgga ctatagcagc     2520

gttatgctaa ccagtgagga agaaattaaa accaccaacc cagtggccac agaacagtac     2580

ggcgtggtgg ccgataacct gcaacagcaa aacgccgctc ctattgtagg ggccgtcaac     2640

agtcaaggag ccttacctgg catggtctgg cagaaccggg acgtgtacct gcagggtcct     2700

atctgggcca agattcctca cacggacgga aactttcatc cctcgccgct gatgggaggc     2760

tttggactga aacacccgcc tcctcagatc ctgattaaga atacacctgt tcccgcggat     2820

cctccaacta ccttcagtca agctaagctg gcgtcgttca tcacgcagta cagcaccgga     2880

caggtcagcg tggaaattga atgggagctg cagaaagaaa acagcaaacg ctggaaccca     2940

gagattcaat acacttccaa ctactacaaa tctacaaatg tggactttgc tgttaacaca     3000

gatggcactt attctgagcc tcgccccatt ggcacccgtt acctcacccg taatctgtaa     3060

ttgcttgtta atcaataaac cggttgattc gtttcagttg aactttggtc tctgcgaagg     3120

gcgaattc                                                              3128


<210>  89
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  89

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Pro Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Asp 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  90
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  90

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  91
<211>  2172
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  91
atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag       60

tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa      120

gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga      180

ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag      240

cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag      300

gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc      360

aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc      420

ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc      480

aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc      540

ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca      600

ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc      660

gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc      720

agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc      780

aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc      840

cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg      900

tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc      960

accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag     1020

ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc     1080

tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc     1140

gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac     1200

aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt     1260

cagaacctgt tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc     1320

acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc     1380

tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg     1440

gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg     1500

agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc     1560

tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc     1620

acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc     1680

gtggcgtaca acgtcggcgg gcagatggcc accaacaacc agagctccac cactgccccc     1740

gcgaccggca cgtacaacct ccaggaaatc gtgcccggca gcgtgtggat ggagagggac     1800

gtgtacctcc aaggacccat ctgggccaag atcccagaga cgggggcgca ctttcacccc     1860

tctccggcca tgggcggatt cggactcaaa cacccaccgc ccatgatgct catcaagaac     1920

acgcctgtgc ccggaaatat caccagcttc tcggacgtgc ccgtcagcag cttcatcacc     1980

cagtacagca ccgggcaggt caccgtggag atggagtggg agctcaagaa ggaaaactcc     2040

aagaggtgga acccagagat ccagtacaca aacaactaca acgaccccca gtttgtggac     2100

tttgccccgg acagcaccgg ggaatacaga accaccagac ctatcggaac ccgatacctt     2160

acccgacccc tt                                                         2172


<210>  92
<211>  720
<212>  PRT
<213>  Adeno-associated virus

<400>  92

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 
225                 230                 235                 240 


Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 
                245                 250                 255     


Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 
305                 310                 315                 320 


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
                325                 330                 335     


Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 
            340                 345                 350         


Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 
    370                 375                 380                 


Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 
                405                 410                 415     


Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 
        435                 440                 445             


Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 
    450                 455                 460                 


Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 
465                 470                 475                 480 


Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 
                485                 490                 495     


Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 
            500                 505                 510         


Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 
        515                 520                 525             


Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 
    530                 535                 540                 


Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 
545                 550                 555                 560 


Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 
                565                 570                 575     


Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 
            580                 585                 590         


Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
        595                 600                 605             


Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 
    610                 615                 620                 


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 
625                 630                 635                 640 


Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 
                645                 650                 655     


Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 
            660                 665                 670         


Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 
        675                 680                 685             


Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 
    690                 695                 700                 


Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 
705                 710                 715                 720 


<210>  93
<211>  724
<212>  PRT
<213>  Adeno-associated virus 5

<400>  93

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 
225                 230                 235                 240 


Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 
                245                 250                 255     


Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 
305                 310                 315                 320 


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
                325                 330                 335     


Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 
            340                 345                 350         


Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 
    370                 375                 380                 


Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 
                405                 410                 415     


Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 
        435                 440                 445             


Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 
    450                 455                 460                 


Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 
465                 470                 475                 480 


Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 
                485                 490                 495     


Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 
            500                 505                 510         


Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 
        515                 520                 525             


Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 
    530                 535                 540                 


Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 
545                 550                 555                 560 


Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 
                565                 570                 575     


Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 
            580                 585                 590         


Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
        595                 600                 605             


Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 
    610                 615                 620                 


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 
625                 630                 635                 640 


Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 
                645                 650                 655     


Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 
            660                 665                 670         


Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 
        675                 680                 685             


Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 
    690                 695                 700                 


Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 
705                 710                 715                 720 


Thr Arg Pro Leu 
                


<210>  94
<211>  2175
<212>  PRT
<213>  Adeno-associated virus 5

<400>  94

Ala Thr Gly Thr Cys Thr Thr Thr Thr Gly Thr Thr Gly Ala Thr Cys 
1               5                   10                  15      


Ala Cys Cys Cys Thr Cys Cys Ala Gly Ala Thr Thr Gly Gly Thr Thr 
            20                  25                  30          


Gly Gly Ala Ala Gly Ala Ala Gly Thr Thr Gly Gly Thr Gly Ala Ala 
        35                  40                  45              


Gly Gly Thr Cys Thr Thr Cys Gly Cys Gly Ala Gly Thr Thr Thr Thr 
    50                  55                  60                  


Thr Gly Gly Gly Cys Cys Thr Thr Gly Ala Ala Gly Cys Gly Gly Gly 
65                  70                  75                  80  


Cys Cys Cys Ala Cys Cys Gly Ala Ala Ala Cys Cys Ala Ala Ala Ala 
                85                  90                  95      


Cys Cys Cys Ala Ala Thr Cys Ala Gly Cys Ala Gly Cys Ala Thr Cys 
            100                 105                 110         


Ala Ala Gly Ala Thr Cys Ala Ala Gly Cys Cys Cys Gly Thr Gly Gly 
        115                 120                 125             


Thr Cys Thr Thr Gly Thr Gly Cys Thr Gly Cys Cys Thr Gly Gly Thr 
    130                 135                 140                 


Thr Ala Thr Ala Ala Cys Thr Ala Thr Cys Thr Cys Gly Gly Ala Cys 
145                 150                 155                 160 


Cys Cys Gly Gly Ala Ala Ala Cys Gly Gly Thr Cys Thr Cys Gly Ala 
                165                 170                 175     


Thr Cys Gly Ala Gly Gly Ala Gly Ala Gly Cys Cys Thr Gly Thr Cys 
            180                 185                 190         


Ala Ala Cys Ala Gly Gly Gly Cys Ala Gly Ala Cys Gly Ala Gly Gly 
        195                 200                 205             


Thr Cys Gly Cys Gly Cys Gly Ala Gly Ala Gly Cys Ala Cys Gly Ala 
    210                 215                 220                 


Cys Ala Thr Cys Thr Cys Gly Thr Ala Cys Ala Ala Cys Gly Ala Gly 
225                 230                 235                 240 


Cys Ala Gly Cys Thr Thr Gly Ala Gly Gly Cys Gly Gly Gly Ala Gly 
                245                 250                 255     


Ala Cys Ala Ala Cys Cys Cys Cys Thr Ala Cys Cys Thr Cys Ala Ala 
            260                 265                 270         


Gly Thr Ala Cys Ala Ala Cys Cys Ala Cys Gly Cys Gly Gly Ala Cys 
        275                 280                 285             


Gly Cys Cys Gly Ala Gly Thr Thr Thr Cys Ala Gly Gly Ala Gly Ala 
    290                 295                 300                 


Ala Gly Cys Thr Cys Gly Cys Cys Gly Ala Cys Gly Ala Cys Ala Cys 
305                 310                 315                 320 


Ala Thr Cys Cys Thr Thr Cys Gly Gly Gly Gly Gly Ala Ala Ala Cys 
                325                 330                 335     


Cys Thr Cys Gly Gly Ala Ala Ala Gly Gly Cys Ala Gly Thr Cys Thr 
            340                 345                 350         


Thr Thr Cys Ala Gly Gly Cys Cys Ala Ala Gly Ala Ala Ala Ala Gly 
        355                 360                 365             


Gly Gly Thr Thr Cys Thr Cys Gly Ala Ala Cys Cys Thr Thr Thr Thr 
    370                 375                 380                 


Gly Gly Cys Cys Thr Gly Gly Thr Thr Gly Ala Ala Gly Ala Gly Gly 
385                 390                 395                 400 


Gly Thr Gly Cys Thr Ala Ala Gly Ala Cys Gly Gly Cys Cys Cys Cys 
                405                 410                 415     


Thr Ala Cys Cys Gly Gly Ala Ala Ala Gly Cys Gly Gly Ala Thr Ala 
            420                 425                 430         


Gly Ala Cys Gly Ala Cys Cys Ala Cys Thr Thr Thr Cys Cys Ala Ala 
        435                 440                 445             


Ala Ala Ala Gly Ala Ala Ala Gly Ala Ala Gly Gly Cys Thr Cys Gly 
    450                 455                 460                 


Gly Ala Cys Cys Gly Ala Ala Gly Ala Gly Gly Ala Cys Thr Cys Cys 
465                 470                 475                 480 


Ala Ala Gly Cys Cys Thr Thr Cys Cys Ala Cys Cys Thr Cys Gly Thr 
                485                 490                 495     


Cys Ala Gly Ala Cys Gly Cys Cys Gly Ala Ala Gly Cys Thr Gly Gly 
            500                 505                 510         


Ala Cys Cys Cys Ala Gly Cys Gly Gly Ala Thr Cys Cys Cys Ala Gly 
        515                 520                 525             


Cys Ala Gly Cys Thr Gly Cys Ala Ala Ala Thr Cys Cys Cys Ala Gly 
    530                 535                 540                 


Cys Cys Cys Ala Ala Cys Cys Ala Gly Cys Cys Thr Cys Ala Ala Gly 
545                 550                 555                 560 


Thr Thr Thr Gly Gly Gly Ala Gly Cys Thr Gly Ala Thr Ala Cys Ala 
                565                 570                 575     


Ala Thr Gly Thr Cys Thr Gly Cys Gly Gly Gly Ala Gly Gly Thr Gly 
            580                 585                 590         


Gly Cys Gly Gly Cys Cys Cys Ala Thr Thr Gly Gly Gly Cys Gly Ala 
        595                 600                 605             


Cys Ala Ala Thr Ala Ala Cys Cys Ala Ala Gly Gly Thr Gly Cys Cys 
    610                 615                 620                 


Gly Ala Thr Gly Gly Ala Gly Thr Gly Gly Gly Cys Ala Ala Thr Gly 
625                 630                 635                 640 


Cys Cys Thr Cys Gly Gly Gly Ala Gly Ala Thr Thr Gly Gly Cys Ala 
                645                 650                 655     


Thr Thr Gly Cys Gly Ala Thr Thr Cys Cys Ala Cys Gly Thr Gly Gly 
            660                 665                 670         


Ala Thr Gly Gly Gly Gly Gly Ala Cys Ala Gly Ala Gly Thr Cys Gly 
        675                 680                 685             


Thr Cys Ala Cys Cys Ala Ala Gly Thr Cys Cys Ala Cys Cys Cys Gly 
    690                 695                 700                 


Ala Ala Cys Cys Thr Gly Gly Gly Thr Gly Cys Thr Gly Cys Cys Cys 
705                 710                 715                 720 


Ala Gly Cys Thr Ala Cys Ala Ala Cys Ala Ala Cys Cys Ala Cys Cys 
                725                 730                 735     


Ala Gly Thr Ala Cys Cys Gly Ala Gly Ala Gly Ala Thr Cys Ala Ala 
            740                 745                 750         


Ala Ala Gly Cys Gly Gly Cys Thr Cys Cys Gly Thr Cys Gly Ala Cys 
        755                 760                 765             


Gly Gly Ala Ala Gly Cys Ala Ala Cys Gly Cys Cys Ala Ala Cys Gly 
    770                 775                 780                 


Cys Cys Thr Ala Cys Thr Thr Thr Gly Gly Ala Thr Ala Cys Ala Gly 
785                 790                 795                 800 


Cys Ala Cys Cys Cys Cys Cys Thr Gly Gly Gly Gly Gly Thr Ala Cys 
                805                 810                 815     


Thr Thr Thr Gly Ala Cys Thr Thr Thr Ala Ala Cys Cys Gly Cys Thr 
            820                 825                 830         


Thr Cys Cys Ala Cys Ala Gly Cys Cys Ala Cys Thr Gly Gly Ala Gly 
        835                 840                 845             


Cys Cys Cys Cys Cys Gly Ala Gly Ala Cys Thr Gly Gly Cys Ala Ala 
    850                 855                 860                 


Ala Gly Ala Cys Thr Cys Ala Thr Cys Ala Ala Cys Ala Ala Cys Thr 
865                 870                 875                 880 


Ala Cys Thr Gly Gly Gly Gly Cys Thr Thr Cys Ala Gly Ala Cys Cys 
                885                 890                 895     


Cys Cys Gly Gly Thr Cys Cys Cys Thr Cys Ala Gly Ala Gly Thr Cys 
            900                 905                 910         


Ala Ala Ala Ala Thr Cys Thr Thr Cys Ala Ala Cys Ala Thr Thr Cys 
        915                 920                 925             


Ala Ala Gly Thr Cys Ala Ala Ala Gly Ala Gly Gly Thr Cys Ala Cys 
    930                 935                 940                 


Gly Gly Thr Gly Cys Ala Gly Gly Ala Cys Thr Cys Cys Ala Cys Cys 
945                 950                 955                 960 


Ala Cys Cys Ala Cys Cys Ala Thr Cys Gly Cys Cys Ala Ala Cys Ala 
                965                 970                 975     


Ala Cys Cys Thr Cys Ala Cys Cys Thr Cys Cys Ala Cys Cys Gly Thr 
            980                 985                 990         


Cys Cys Ala Ala Gly Thr Gly Thr  Thr Thr Ala Cys Gly  Gly Ala Cys 
        995                 1000                 1005             


Gly Ala  Cys Gly Ala Cys Thr  Ala Cys Cys Ala Gly  Cys Thr Gly 
    1010                 1015                 1020             


Cys Cys  Cys Thr Ala Cys Gly  Thr Cys Gly Thr Cys  Gly Gly Cys 
    1025                 1030                 1035             


Ala Ala  Cys Gly Gly Gly Ala  Cys Cys Gly Ala Gly  Gly Gly Ala 
    1040                 1045                 1050             


Thr Gly  Cys Cys Thr Gly Cys  Cys Gly Gly Cys Cys  Thr Thr Cys 
    1055                 1060                 1065             


Cys Cys  Thr Cys Cys Gly Cys  Ala Gly Gly Thr Cys  Thr Thr Thr 
    1070                 1075                 1080             


Ala Cys  Gly Cys Thr Gly Cys  Cys Gly Cys Ala Gly  Thr Ala Cys 
    1085                 1090                 1095             


Gly Gly  Thr Thr Ala Cys Gly  Cys Gly Ala Cys Gly  Cys Thr Gly 
    1100                 1105                 1110             


Ala Ala  Cys Cys Gly Cys Gly  Ala Cys Ala Ala Cys  Ala Cys Ala 
    1115                 1120                 1125             


Gly Ala  Ala Ala Ala Thr Cys  Cys Cys Ala Cys Cys  Gly Ala Gly 
    1130                 1135                 1140             


Ala Gly  Gly Ala Gly Cys Ala  Gly Cys Thr Thr Cys  Thr Thr Cys 
    1145                 1150                 1155             


Thr Gly  Cys Cys Thr Ala Gly  Ala Gly Thr Ala Cys  Thr Thr Thr 
    1160                 1165                 1170             


Cys Cys  Cys Ala Gly Cys Ala  Ala Gly Ala Thr Gly  Cys Thr Gly 
    1175                 1180                 1185             


Ala Gly  Ala Ala Cys Gly Gly  Gly Cys Ala Ala Cys  Ala Ala Cys 
    1190                 1195                 1200             


Thr Thr  Thr Gly Ala Gly Thr  Thr Thr Ala Cys Cys  Thr Ala Cys 
    1205                 1210                 1215             


Ala Ala  Cys Thr Thr Thr Gly  Ala Gly Gly Ala Gly  Gly Thr Gly 
    1220                 1225                 1230             


Cys Cys  Cys Thr Thr Cys Cys  Ala Cys Thr Cys Cys  Ala Gly Cys 
    1235                 1240                 1245             


Thr Thr  Cys Gly Cys Thr Cys  Cys Cys Ala Gly Thr  Cys Ala Gly 
    1250                 1255                 1260             


Ala Ala  Cys Cys Thr Gly Thr  Thr Cys Ala Ala Gly  Cys Thr Gly 
    1265                 1270                 1275             


Gly Cys  Cys Ala Ala Cys Cys  Cys Gly Cys Thr Gly  Gly Thr Gly 
    1280                 1285                 1290             


Gly Ala  Cys Cys Ala Gly Thr  Ala Cys Thr Thr Gly  Thr Ala Cys 
    1295                 1300                 1305             


Cys Gly  Cys Thr Thr Cys Gly  Thr Gly Ala Gly Cys  Ala Cys Ala 
    1310                 1315                 1320             


Ala Ala  Thr Ala Ala Cys Ala  Cys Thr Gly Gly Cys  Gly Gly Ala 
    1325                 1330                 1335             


Gly Thr  Cys Cys Ala Gly Thr  Thr Cys Ala Ala Cys  Ala Ala Gly 
    1340                 1345                 1350             


Ala Ala  Cys Cys Thr Gly Gly  Cys Cys Gly Gly Gly  Ala Gly Ala 
    1355                 1360                 1365             


Thr Ala  Cys Gly Cys Cys Ala  Ala Cys Ala Cys Cys  Thr Ala Cys 
    1370                 1375                 1380             


Ala Ala  Ala Ala Ala Cys Thr  Gly Gly Thr Thr Cys  Cys Cys Gly 
    1385                 1390                 1395             


Gly Gly  Gly Cys Cys Cys Ala  Thr Gly Gly Gly Cys  Cys Gly Ala 
    1400                 1405                 1410             


Ala Cys  Cys Cys Ala Gly Gly  Gly Cys Thr Gly Gly  Ala Ala Cys 
    1415                 1420                 1425             


Cys Thr  Gly Gly Gly Cys Thr  Cys Cys Gly Gly Gly  Gly Thr Cys 
    1430                 1435                 1440             


Ala Ala  Cys Cys Gly Cys Gly  Cys Cys Ala Gly Thr  Gly Thr Cys 
    1445                 1450                 1455             


Ala Gly  Cys Gly Cys Cys Thr  Thr Cys Gly Cys Cys  Ala Cys Gly 
    1460                 1465                 1470             


Ala Cys  Cys Ala Ala Thr Ala  Gly Gly Ala Thr Gly  Gly Ala Gly 
    1475                 1480                 1485             


Cys Thr  Cys Gly Ala Gly Gly  Gly Cys Gly Cys Gly  Ala Gly Thr 
    1490                 1495                 1500             


Thr Ala  Cys Cys Ala Gly Gly  Thr Gly Cys Cys Cys  Cys Cys Gly 
    1505                 1510                 1515             


Cys Ala  Gly Cys Cys Gly Ala  Ala Cys Gly Gly Cys  Ala Thr Gly 
    1520                 1525                 1530             


Ala Cys  Cys Ala Ala Cys Ala  Ala Cys Cys Thr Cys  Cys Ala Gly 
    1535                 1540                 1545             


Gly Gly  Cys Ala Gly Cys Ala  Ala Cys Ala Cys Cys  Thr Ala Thr 
    1550                 1555                 1560             


Gly Cys  Cys Cys Thr Gly Gly  Ala Gly Ala Ala Cys  Ala Cys Thr 
    1565                 1570                 1575             


Ala Thr  Gly Ala Thr Cys Thr  Thr Cys Ala Ala Cys  Ala Gly Cys 
    1580                 1585                 1590             


Cys Ala  Gly Cys Cys Gly Gly  Cys Gly Ala Ala Cys  Cys Cys Gly 
    1595                 1600                 1605             


Gly Gly  Cys Ala Cys Cys Ala  Cys Cys Gly Cys Cys  Ala Cys Gly 
    1610                 1615                 1620             


Thr Ala  Cys Cys Thr Cys Gly  Ala Gly Gly Gly Cys  Ala Ala Cys 
    1625                 1630                 1635             


Ala Thr  Gly Cys Thr Cys Ala  Thr Cys Ala Cys Cys  Ala Gly Cys 
    1640                 1645                 1650             


Gly Ala  Gly Ala Gly Cys Gly  Ala Gly Ala Cys Gly  Cys Ala Gly 
    1655                 1660                 1665             


Cys Cys  Gly Gly Thr Gly Ala  Ala Cys Cys Gly Cys  Gly Thr Gly 
    1670                 1675                 1680             


Gly Cys  Gly Thr Ala Cys Ala  Ala Cys Gly Thr Cys  Gly Gly Cys 
    1685                 1690                 1695             


Gly Gly  Gly Cys Ala Gly Ala  Thr Gly Gly Cys Cys  Ala Cys Cys 
    1700                 1705                 1710             


Ala Ala  Cys Ala Ala Cys Cys  Ala Gly Ala Gly Cys  Thr Cys Cys 
    1715                 1720                 1725             


Ala Cys  Cys Ala Cys Thr Gly  Cys Cys Cys Cys Cys  Gly Cys Gly 
    1730                 1735                 1740             


Ala Cys  Cys Gly Gly Cys Ala  Cys Gly Thr Ala Cys  Ala Ala Cys 
    1745                 1750                 1755             


Cys Thr  Cys Cys Ala Gly Gly  Ala Ala Ala Thr Cys  Gly Thr Gly 
    1760                 1765                 1770             


Cys Cys  Cys Gly Gly Cys Ala  Gly Cys Gly Thr Gly  Thr Gly Gly 
    1775                 1780                 1785             


Ala Thr  Gly Gly Ala Gly Ala  Gly Gly Gly Ala Cys  Gly Thr Gly 
    1790                 1795                 1800             


Thr Ala  Cys Cys Thr Cys Cys  Ala Ala Gly Gly Ala  Cys Cys Cys 
    1805                 1810                 1815             


Ala Thr  Cys Thr Gly Gly Gly  Cys Cys Ala Ala Gly  Ala Thr Cys 
    1820                 1825                 1830             


Cys Cys  Ala Gly Ala Gly Ala  Cys Gly Gly Gly Gly  Gly Cys Gly 
    1835                 1840                 1845             


Cys Ala  Cys Thr Thr Thr Cys  Ala Cys Cys Cys Cys  Thr Cys Thr 
    1850                 1855                 1860             


Cys Cys  Gly Gly Cys Cys Ala  Thr Gly Gly Gly Cys  Gly Gly Ala 
    1865                 1870                 1875             


Thr Thr  Cys Gly Gly Ala Cys  Thr Cys Ala Ala Ala  Cys Ala Cys 
    1880                 1885                 1890             


Cys Cys  Ala Cys Cys Gly Cys  Cys Cys Ala Thr Gly  Ala Thr Gly 
    1895                 1900                 1905             


Cys Thr  Cys Ala Thr Cys Ala  Ala Gly Ala Ala Cys  Ala Cys Gly 
    1910                 1915                 1920             


Cys Cys  Thr Gly Thr Gly Cys  Cys Cys Gly Gly Ala  Ala Ala Thr 
    1925                 1930                 1935             


Ala Thr  Cys Ala Cys Cys Ala  Gly Cys Thr Thr Cys  Thr Cys Gly 
    1940                 1945                 1950             


Gly Ala  Cys Gly Thr Gly Cys  Cys Cys Gly Thr Cys  Ala Gly Cys 
    1955                 1960                 1965             


Ala Gly  Cys Thr Thr Cys Ala  Thr Cys Ala Cys Cys  Cys Ala Gly 
    1970                 1975                 1980             


Thr Ala  Cys Ala Gly Cys Ala  Cys Cys Gly Gly Gly  Cys Ala Gly 
    1985                 1990                 1995             


Gly Thr  Cys Ala Cys Cys Gly  Thr Gly Gly Ala Gly  Ala Thr Gly 
    2000                 2005                 2010             


Gly Ala  Gly Thr Gly Gly Gly  Ala Gly Cys Thr Cys  Ala Ala Gly 
    2015                 2020                 2025             


Ala Ala  Gly Gly Ala Ala Ala  Ala Cys Thr Cys Cys  Ala Ala Gly 
    2030                 2035                 2040             


Ala Gly  Gly Thr Gly Gly Ala  Ala Cys Cys Cys Ala  Gly Ala Gly 
    2045                 2050                 2055             


Ala Thr  Cys Cys Ala Gly Thr  Ala Cys Ala Cys Ala  Ala Ala Cys 
    2060                 2065                 2070             


Ala Ala  Cys Thr Ala Cys Ala  Ala Cys Gly Ala Cys  Cys Cys Cys 
    2075                 2080                 2085             


Cys Ala  Gly Thr Thr Thr Gly  Thr Gly Gly Ala Cys  Thr Thr Thr 
    2090                 2095                 2100             


Gly Cys  Cys Cys Cys Gly Gly  Ala Cys Ala Gly Cys  Ala Cys Cys 
    2105                 2110                 2115             


Gly Gly  Gly Gly Ala Ala Thr  Ala Cys Ala Gly Ala  Ala Cys Cys 
    2120                 2125                 2130             


Ala Cys  Cys Ala Gly Ala Cys  Cys Thr Ala Thr Cys  Gly Gly Ala 
    2135                 2140                 2145             


Ala Cys  Cys Cys Gly Ala Thr  Ala Cys Cys Thr Thr  Ala Cys Cys 
    2150                 2155                 2160             


Cys Gly  Ala Cys Cys Cys Cys  Thr Thr Thr Ala Ala  
    2165                 2170                 2175 


<210>  95
<211>  2208
<212>  DNA
<213>  Adeno-associated virus 6

<400>  95
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc catttctcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaggc agtgggacgg tcatcctttt actgcctgga atatttccca     1200

tcgcagatgc tgagaacggg caataacttt accttcagct acaccttcga ggacgtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgggggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt accggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac aaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacggatgg acactttcac ccgtctcctc tcatgggcgg ctttggactt     1920

aagcacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggca     1980

gagttttcgg ctacaaagtt tgcttcattc atcacccagt attccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctg                  2208


<210>  96
<211>  736
<212>  PRT
<213>  Adeno-associated virus 6

<400>  96

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  97
<211>  623
<212>  PRT
<213>  Adeno-associated virus 6

<400>  97

Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Val Gln Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Leu His Ile Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Asp Lys Leu Val Gln Thr Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Glu Tyr Ile 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu Val Ala His Asp 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Leu Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ala Leu Thr Lys Ser Ala Pro Asp Tyr Leu Val Gly Pro Ala 
        275                 280                 285             


Pro Pro Ala Asp Ile Lys Thr Asn Arg Ile Tyr Arg Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Ala Tyr Ala Gly Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Gln Lys Arg Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Glu His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Glu Phe Phe Arg Trp Ala Gln Asp His Val Thr Glu Val 
465                 470                 475                 480 


Ala His Glu Phe Tyr Val Arg Lys Gly Gly Ala Asn Lys Arg Pro Ala 
                485                 490                 495     


Pro Asp Asp Ala Asp Lys Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 
            500                 505                 510         


Ala Asp Pro Ser Thr Ser Asp Ala Glu Gly Ala Pro Val Asp Phe Ala 
        515                 520                 525             


Asp Arg Tyr Gln Asn Lys Cys Ser Arg His Ala Gly Met Leu Gln Met 
    530                 535                 540                 


Leu Phe Pro Cys Lys Thr Cys Glu Arg Met Asn Gln Asn Phe Asn Ile 
545                 550                 555                 560 


Cys Phe Thr His Gly Thr Arg Asp Cys Ser Glu Cys Phe Pro Gly Val 
                565                 570                 575     


Ser Glu Ser Gln Pro Val Val Arg Lys Arg Thr Tyr Arg Lys Leu Cys 
            580                 585                 590         


Ala Ile His His Leu Leu Gly Arg Ala Pro Glu Ile Ala Cys Ser Ala 
        595                 600                 605             


Cys Asp Leu Val Asn Val Asp Leu Asp Asp Cys Val Ser Glu Gln 
    610                 615                 620             


<210>  98
<211>  4683
<212>  DNA
<213>  Adeno-associated virus 6

<400>  98
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgtatt agaggtcacg tgagtgtttt gcgacatttt gcgacaccat      240

gtggtcacgc tgggtattta agcccgagtg agcacgcagg gtctccattt tgaagcggga      300

ggtttgaacg cgcagcgcca tgccggggtt ttacgagatt gtgattaagg tccccagcga      360

ccttgacgag catctgcccg gcatttctga cagctttgtg aactgggtgg ccgagaagga      420

atgggagttg ccgccagatt ctgacatgga tctgaatctg attgagcagg cacccctgac      480

cgtggccgag aagctgcagc gcgacttcct ggtccagtgg cgccgcgtga gtaaggcccc      540

ggaggccctc ttctttgttc agttcgagaa gggcgagtcc tacttccacc tccatattct      600

ggtggagacc acgggggtca aatccatggt gctgggccgc ttcctgagtc agattaggga      660

caagctggtg cagaccatct accgcgggat cgagccgacc ctgcccaact ggttcgcggt      720

gaccaagacg cgtaatggcg ccggaggggg gaacaaggtg gtggacgagt gctacatccc      780

caactacctc ctgcccaaga ctcagcccga gctgcagtgg gcgtggacta acatggagga      840

gtatataagc gcgtgtttaa acctggccga gcgcaaacgg ctcgtggcgc acgacctgac      900

ccacgtcagc cagacccagg agcagaacaa ggagaatctg aaccccaatt ctgacgcgcc      960

tgtcatccgg tcaaaaacct ccgcacgcta catggagctg gtcgggtggc tggtggaccg     1020

gggcatcacc tccgagaagc agtggatcca ggaggaccag gcctcgtaca tctccttcaa     1080

cgccgcctcc aactcgcggt cccagatcaa ggccgctctg gacaatgccg gcaagatcat     1140

ggcgctgacc aaatccgcgc ccgactacct ggtaggcccc gctccgcccg ccgacattaa     1200

aaccaaccgc atttaccgca tcctggagct gaacggctac gaccctgcct acgccggctc     1260

cgtctttctc ggctgggccc agaaaaggtt cggaaaacgc aacaccatct ggctgtttgg     1320

gccggccacc acgggcaaga ccaacatcgc ggaagccatc gcccacgccg tgcccttcta     1380

cggctgcgtc aactggacca atgagaactt tcccttcaac gattgcgtcg acaagatggt     1440

gatctggtgg gaggagggca agatgacggc caaggtcgtg gagtccgcca aggccattct     1500

cggcggcagc aaggtgcgcg tggaccaaaa gtgcaagtcg tccgcccaga tcgatcccac     1560

ccccgtgatc gtcacctcca acaccaacat gtgcgccgtg attgacggga acagcaccac     1620

cttcgagcac cagcagccgt tgcaggaccg gatgttcaaa tttgaactca cccgccgtct     1680

ggagcatgac tttggcaagg tgacaaagca ggaagtcaaa gagttcttcc gctgggcgca     1740

ggatcacgtg accgaggtgg cgcatgagtt ctacgtcaga aagggtggag ccaacaagag     1800

acccgccccc gatgacgcgg ataaaagcga gcccaagcgg gcctgcccct cagtcgcgga     1860

tccatcgacg tcagacgcgg aaggagctcc ggtggacttt gccgacaggt accaaaacaa     1920

atgttctcgt cacgcgggca tgcttcagat gctgtttccc tgcaaaacat gcgagagaat     1980

gaatcagaat ttcaacattt gcttcacgca cgggaccaga gactgttcag aatgtttccc     2040

cggcgtgtca gaatctcaac cggtcgtcag aaagaggacg tatcggaaac tctgtgccat     2100

tcatcatctg ctggggcggg ctcccgagat tgcttgctcg gcctgcgatc tggtcaacgt     2160

ggatctggat gactgtgttt ctgagcaata aatgacttaa accaggtatg gctgccgatg     2220

gttatcttcc agattggctc gaggacaacc tctctgaggg cattcgcgag tggtgggact     2280

tgaaacctgg agccccgaaa cccaaagcca accagcaaaa gcaggacgac ggccggggtc     2340

tggtgcttcc tggctacaag tacctcggac ccttcaacgg actcgacaag ggggagcccg     2400

tcaacgcggc ggatgcagcg gccctcgagc acgacaaggc ctacgaccag cagctcaaag     2460

cgggtgacaa tccgtacctg cggtataacc acgccgacgc cgagtttcag gagcgtctgc     2520

aagaagatac gtcttttggg ggcaacctcg ggcgagcagt cttccaggcc aagaagaggg     2580

ttctcgaacc ttttggtctg gttgaggaag gtgctaagac ggctcctgga aagaaacgtc     2640

cggtagagca gtcgccacaa gagccagact cctcctcggg cattggcaag acaggccagc     2700

agcccgctaa aaagagactc aattttggtc agactggcga ctcagagtca gtccccgacc     2760

cacaacctct cggagaacct ccagcaaccc ccgctgctgt gggacctact acaatggctt     2820

caggcggtgg cgcaccaatg gcagacaata acgaaggcgc cgacggagtg ggtaatgcct     2880

caggaaattg gcattgcgat tccacatggc tgggcgacag agtcatcacc accagcaccc     2940

gaacatgggc cttgcccacc tataacaacc acctctacaa gcaaatctcc agtgcttcaa     3000

cgggggccag caacgacaac cactacttcg gctacagcac cccctggggg tattttgatt     3060

tcaacagatt ccactgccat ttctcaccac gtgactggca gcgactcatc aacaacaatt     3120

ggggattccg gcccaagaga ctcaacttca agctcttcaa catccaagtc aaggaggtca     3180

cgacgaatga tggcgtcacg accatcgcta ataaccttac cagcacggtt caagtcttct     3240

cggactcgga gtaccagttg ccgtacgtcc tcggctctgc gcaccagggc tgcctccctc     3300

cgttcccggc ggacgtgttc atgattccgc agtacggcta cctaacgctc aacaatggca     3360

gccaggcagt gggacggtca tccttttact gcctggaata tttcccatcg cagatgctga     3420

gaacgggcaa taactttacc ttcagctaca ccttcgagga cgtgcctttc cacagcagct     3480

acgcgcacag ccagagcctg gaccggctga tgaatcctct catcgaccag tacctgtatt     3540

acctgaacag aactcagaat cagtccggaa gtgcccaaaa caaggacttg ctgtttagcc     3600

gggggtctcc agctggcatg tctgttcagc ccaaaaactg gctacctgga ccctgttacc     3660

ggcagcagcg cgtttctaaa acaaaaacag acaacaacaa cagcaacttt acctggactg     3720

gtgcttcaaa atataacctt aatgggcgtg aatctataat caaccctggc actgctatgg     3780

cctcacacaa agacgacaaa gacaagttct ttcccatgag cggtgtcatg atttttggaa     3840

aggagagcgc cggagcttca aacactgcat tggacaatgt catgatcaca gacgaagagg     3900

aaatcaaagc cactaacccc gtggccaccg aaagatttgg gactgtggca gtcaatctcc     3960

agagcagcag cacagaccct gcgaccggag atgtgcatgt tatgggagcc ttacctggaa     4020

tggtgtggca agacagagac gtatacctgc agggtcctat ttgggccaaa attcctcaca     4080

cggatggaca ctttcacccg tctcctctca tgggcggctt tggacttaag cacccgcctc     4140

ctcagatcct catcaaaaac acgcctgttc ctgcgaatcc tccggcagag ttttcggcta     4200

caaagtttgc ttcattcatc acccagtatt ccacaggaca agtgagcgtg gagattgaat     4260

gggagctgca gaaagaaaac agcaaacgct ggaatcccga agtgcagtat acatctaact     4320

atgcaaaatc tgccaacgtt gatttcactg tggacaacaa tggactttat actgagcctc     4380

gccccattgg cacccgttac ctcacccgtc ccctgtaatt gtgtgttaat caataaaccg     4440

gttaattcgt gtcagttgaa ctttggtctc atgtcgttat tatcttatct ggtcaccata     4500

gcaaccggtt acacattaac tgcttagttg cgcttcgcga atacccctag tgatggagtt     4560

gcccactccc tctatgcgcg ctcgctcgct cggtggggcc ggcagagcag agctctgccg     4620

tctgcggacc tttggtccgc aggccccacc gagcgagcga gcgcgcatag agggagtggg     4680

caa                                                                   4683


<210>  99
<211>  2211
<212>  DNA
<213>  Adeno-associated virus 6

<400>  99
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc catttctcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaggc agtgggacgg tcatcctttt actgcctgga atatttccca     1200

tcgcagatgc tgagaacggg caataacttt accttcagct acaccttcga ggacgtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgggggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt accggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac aaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacggatgg acactttcac ccgtctcctc tcatgggcgg ctttggactt     1920

aagcacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggca     1980

gagttttcgg ctacaaagtt tgcttcattc atcacccagt attccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210>  100
<211>  736
<212>  PRT
<213>  Adeno-associated virus

<400>  100

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  101
<211>  736
<212>  PRT
<213>  Adeno-associated virus

<400>  101

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  102
<211>  736
<212>  PRT
<213>  Adeno-associated virus

<400>  102

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  103
<211>  736
<212>  PRT
<213>  Adeno-associated virus

<400>  103

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  104
<211>  2214
<212>  DNA
<213>  Adeno-associated virus 7

<400>  104
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

aacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtcattt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

gcaaagaaga gaccggtaga gccgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctctcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacag tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

attaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccagtg aaactgcagg tagtaccaac gacaacacct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagaagctgc ggttcaagct cttcaacatc      960

caggtcaagg aggtcacgac gaatgacggc gttacgacca tcgctaataa ccttaccagc     1020

acgattcagg tattctcgga ctcggaatac cagctgccgt acgtcctcgg ctctgcgcac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttcctcagta cggctacctg     1140

actctcaaca atggcagtca gtctgtggga cgttcctcct tctactgcct ggagtacttc     1200

ccctctcaga tgctgagaac gggcaacaac tttgagttca gctacagctt cgaggacgtg     1260

cctttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcccctcatc     1320

gaccagtact tgtactacct ggccagaaca cagagtaacc caggaggcac agctggcaat     1380

cgggaactgc agttttacca gggcgggcct tcaactatgg ccgaacaagc caagaattgg     1440

ttacctggac cttgcttccg gcaacaaaga gtctccaaaa cgctggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggcagaaa ctcgttggtt     1560

aatcccggcg tcgccatggc aactcacaag gacgacgagg accgcttttt cccatccagc     1620

ggagtcctga tttttggaaa aactggagca actaacaaaa ctacattgga aaatgtgtta     1680

atgacaaatg aagaagaaat tcgtcctact aatcctgtag ccacggaaga atacgggata     1740

gtcagcagca acttacaagc ggctaatact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggcatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga tggcaacttt cacccgtctc ctttgatggg cggctttgga     1920

cttaaacatc cgcctcctca gatcctgatc aagaacactc ccgttcccgc taatcctccg     1980

gaggtgttta ctcctgccaa gtttgcttcg ttcatcacac agtacagcac cggacaagtc     2040

agcgtggaaa tcgagtggga gctgcagaag gaaaacagca agcgctggaa cccggagatt     2100

cagtacacct ccaactttga aaagcagact ggtgtggact ttgccgttga cagccagggt     2160

gtttactctg agcctcgccc tattggcact cgttacctca cccgtaatct gtaa           2214


<210>  105
<211>  738
<212>  PRT
<213>  Adeno-associated virus 7

<400>  105

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  106
<211>  737
<212>  PRT
<213>  Adeno-associated virus 7

<400>  106

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Ala Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Val Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Glu Thr Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Pro Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Ser Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Thr Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Glu Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  107
<211>  623
<212>  PRT
<213>  Adeno-associated virus 7

<400>  107

Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Val Gln Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Leu His Val Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Glu Lys Leu Val Gln Thr Ile Tyr Arg Gly Val Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Glu Tyr Ile 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Leu Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ala Leu Thr Lys Ser Ala Pro Asp Tyr Leu Val Gly Pro Ser 
        275                 280                 285             


Leu Pro Ala Asp Ile Lys Thr Asn Arg Ile Tyr Arg Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Ala Tyr Ala Gly Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Gln Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Glu His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Glu Phe Phe Arg Trp Ala Ser Asp His Val Thr Glu Val 
465                 470                 475                 480 


Ala His Glu Phe Tyr Val Arg Lys Gly Gly Ala Ser Lys Arg Pro Ala 
                485                 490                 495     


Pro Asp Asp Ala Asp Ile Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 
            500                 505                 510         


Ala Asp Pro Ser Thr Ser Asp Ala Glu Gly Ala Pro Val Asp Phe Ala 
        515                 520                 525             


Asp Arg Tyr Gln Asn Lys Cys Ser Arg His Ala Gly Met Ile Gln Met 
    530                 535                 540                 


Leu Phe Pro Cys Lys Thr Cys Glu Arg Met Asn Gln Asn Phe Asn Ile 
545                 550                 555                 560 


Cys Phe Thr His Gly Val Arg Asp Cys Leu Glu Cys Phe Pro Gly Val 
                565                 570                 575     


Ser Glu Ser Gln Pro Val Val Arg Lys Lys Thr Tyr Arg Lys Leu Cys 
            580                 585                 590         


Ala Ile His His Leu Leu Gly Arg Ala Pro Glu Ile Ala Cys Ser Ala 
        595                 600                 605             


Cys Asp Leu Val Asn Val Asp Leu Asp Asp Cys Val Ser Glu Gln 
    610                 615                 620             


<210>  108
<211>  4721
<212>  DNA
<213>  Adeno-associated virus 7

<400>  108
ttggccactc cctctatgcg cgctcgctcg ctcggtgggg cctgcggacc aaaggtccgc       60

agacggcaga gctctgctct gccggcccca ccgagcgagc gagcgcgcat agagggagtg      120

gccaactcca tcactagggg taccgcgaag cgcctcccac gctgccgcgt cagcgctgac      180

gtaaatcacg tcatagggga gtggtcctgt attagctgtc acgtgagtgc ttttgcgaca      240

ttttgcgaca ccacgtggcc atttgaggta tatatggccg agtgagcgag caggatctcc      300

attttgaccg cgaaatttga acgagcagca gccatgccgg gtttctacga gatcgtgatc      360

aaggtgccga gcgacctgga cgagcacctg ccgggcattt ctgactcgtt tgtgaactgg      420

gtggccgaga aggaatggga gctgcccccg gattctgaca tggatctgaa tctgatcgag      480

caggcacccc tgaccgtggc cgagaagctg cagcgcgact tcctggtcca atggcgccgc      540

gtgagtaagg ccccggaggc cctgttcttt gttcagttcg agaagggcga gagctacttc      600

caccttcacg ttctggtgga gaccacgggg gtcaagtcca tggtgctagg ccgcttcctg      660

agtcagattc gggagaagct ggtccagacc atctaccgcg gggtcgagcc cacgctgccc      720

aactggttcg cggtgaccaa gacgcgtaat ggcgccggcg gggggaacaa ggtggtggac      780

gagtgctaca tccccaacta cctcctgccc aagacccagc ccgagctgca gtgggcgtgg      840

actaacatgg aggagtatat aagcgcgtgt ttgaacctgg ccgaacgcaa acggctcgtg      900

gcgcagcacc tgacccacgt cagccagacg caggagcaga acaaggagaa tctgaacccc      960

aattctgacg cgcccgtgat caggtcaaaa acctccgcgc gctacatgga gctggtcggg     1020

tggctggtgg accggggcat cacctccgag aagcagtgga tccaggagga ccaggcctcg     1080

tacatctcct tcaacgccgc ctccaactcg cggtcccaga tcaaggccgc gctggacaat     1140

gccggcaaga tcatggcgct gaccaaatcc gcgcccgact acctggtggg gccctcgctg     1200

cccgcggaca ttaaaaccaa ccgcatctac cgcatcctgg agctgaacgg gtacgatcct     1260

gcctacgccg gctccgtctt tctcggctgg gcccagaaaa agttcgggaa gcgcaacacc     1320

atctggctgt ttgggcccgc caccaccggc aagaccaaca ttgcggaagc catcgcccac     1380

gccgtgccct tctacggctg cgtcaactgg accaatgaga actttccctt caacgattgc     1440

gtcgacaaga tggtgatctg gtgggaggag ggcaagatga cggccaaggt cgtggagtcc     1500

gccaaggcca ttctcggcgg cagcaaggtg cgcgtggacc aaaagtgcaa gtcgtccgcc     1560

cagatcgacc ccacccccgt gatcgtcacc tccaacacca acatgtgcgc cgtgattgac     1620

gggaacagca ccaccttcga gcaccagcag ccgttgcagg accggatgtt caaatttgaa     1680

ctcacccgcc gtctggagca cgactttggc aaggtgacga agcaggaagt caaagagttc     1740

ttccgctggg ccagtgatca cgtgaccgag gtggcgcatg agttctacgt cagaaagggc     1800

ggagccagca aaagacccgc ccccgatgac gcggatataa gcgagcccaa gcgggcctgc     1860

ccctcagtcg cggatccatc gacgtcagac gcggaaggag ctccggtgga ctttgccgac     1920

aggtaccaaa acaaatgttc tcgtcacgcg ggcatgattc agatgctgtt tccctgcaaa     1980

acgtgcgaga gaatgaatca gaatttcaac atttgcttca cacacggggt cagagactgt     2040

ttagagtgtt tccccggcgt gtcagaatct caaccggtcg tcagaaaaaa gacgtatcgg     2100

aaactctgcg cgattcatca tctgctgggg cgggcgcccg agattgcttg ctcggcctgc     2160

gacctggtca acgtggacct ggacgactgc gtttctgagc aataaatgac ttaaaccagg     2220

tatggctgcc gatggttatc ttccagattg gctcgaggac aacctctctg agggcattcg     2280

cgagtggtgg gacctgaaac ctggagcccc gaaacccaaa gccaaccagc aaaagcagga     2340

caacggccgg ggtctggtgc ttcctggcta caagtacctc ggacccttca acggactcga     2400

caagggggag cccgtcaacg cggcggacgc agcggccctc gagcacgaca aggcctacga     2460

ccagcagctc aaagcgggtg acaatccgta cctgcggtat aaccacgccg acgccgagtt     2520

tcaggagcgt ctgcaagaag atacgtcatt tgggggcaac ctcgggcgag cagtcttcca     2580

ggccaagaag cgggttctcg aacctctcgg tctggttgag gaaggcgcta agacggctcc     2640

tgcaaagaag agaccggtag agccgtcacc tcagcgttcc cccgactcct ccacgggcat     2700

cggcaagaaa ggccagcagc ccgccagaaa gagactcaat ttcggtcaga ctggcgactc     2760

agagtcagtc cccgaccctc aacctctcgg agaacctcca gcagcgccct ctagtgtggg     2820

atctggtaca gtggctgcag gcggtggcgc accaatggca gacaataacg aaggtgccga     2880

cggagtgggt aatgcctcag gaaattggca ttgcgattcc acatggctgg gcgacagagt     2940

cattaccacc agcacccgaa cctgggccct gcccacctac aacaaccacc tctacaagca     3000

aatctccagt gaaactgcag gtagtaccaa cgacaacacc tacttcggct acagcacccc     3060

ctgggggtat tttgacttta acagattcca ctgccacttc tcaccacgtg actggcagcg     3120

actcatcaac aacaactggg gattccggcc caagaagctg cggttcaagc tcttcaacat     3180

ccaggtcaag gaggtcacga cgaatgacgg cgttacgacc atcgctaata accttaccag     3240

cacgattcag gtattctcgg actcggaata ccagctgccg tacgtcctcg gctctgcgca     3300

ccagggctgc ctgcctccgt tcccggcgga cgtcttcatg attcctcagt acggctacct     3360

gactctcaac aatggcagtc agtctgtggg acgttcctcc ttctactgcc tggagtactt     3420

cccctctcag atgctgagaa cgggcaacaa ctttgagttc agctacagct tcgaggacgt     3480

gcctttccac agcagctacg cacacagcca gagcctggac cggctgatga atcccctcat     3540

cgaccagtac ttgtactacc tggccagaac acagagtaac ccaggaggca cagctggcaa     3600

tcgggaactg cagttttacc agggcgggcc ttcaactatg gccgaacaag ccaagaattg     3660

gttacctgga ccttgcttcc ggcaacaaag agtctccaaa acgctggatc aaaacaacaa     3720

cagcaacttt gcttggactg gtgccaccaa atatcacctg aacggcagaa actcgttggt     3780

taatcccggc gtcgccatgg caactcacaa ggacgacgag gaccgctttt tcccatccag     3840

cggagtcctg atttttggaa aaactggagc aactaacaaa actacattgg aaaatgtgtt     3900

aatgacaaat gaagaagaaa ttcgtcctac taatcctgta gccacggaag aatacgggat     3960

agtcagcagc aacttacaag cggctaatac tgcagcccag acacaagttg tcaacaacca     4020

gggagcctta cctggcatgg tctggcagaa ccgggacgtg tacctgcagg gtcccatctg     4080

ggccaagatt cctcacacgg atggcaactt tcacccgtct cctttgatgg gcggctttgg     4140

acttaaacat ccgcctcctc agatcctgat caagaacact cccgttcccg ctaatcctcc     4200

ggaggtgttt actcctgcca agtttgcttc gttcatcaca cagtacagca ccggacaagt     4260

cagcgtggaa atcgagtggg agctgcagaa ggaaaacagc aagcgctgga acccggagat     4320

tcagtacacc tccaactttg aaaagcagac tggtgtggac tttgccgttg acagccaggg     4380

tgtttactct gagcctcgcc ctattggcac tcgttacctc acccgtaatc tgtaattgca     4440

tgttaatcaa taaaccggtt gattcgtttc agttgaactt tggtctcctg tgcttcttat     4500

cttatcggtt tccatagcaa ctggttacac attaactgct tgggtgcgct tcacgataag     4560

aacactgacg tcaccgcggt acccctagtg atggagttgg ccactccctc tatgcgcgct     4620

cgctcgctcg gtggggcctg cggaccaaag gtccgcagac ggcagagctc tgctctgccg     4680

gccccaccga gcgagcgagc gcgcatagag ggagtggcca a                         4721


<210>  109
<211>  2214
<212>  DNA
<213>  Adeno-associated virus 7

<400>  109
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

aacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtcattt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

gcaaagaaga gaccggtaga gccgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctctcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacag tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

attaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccagtg aaactgcagg tagtaccaac gacaacacct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagaagctgc ggttcaagct cttcaacatc      960

caggtcaagg aggtcacgac gaatgacggc gttacgacca tcgctaataa ccttaccagc     1020

acgattcagg tattctcgga ctcggaatac cagctgccgt acgtcctcgg ctctgcgcac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttcctcagta cggctacctg     1140

actctcaaca atggcagtca gtctgtggga cgttcctcct tctactgcct ggagtacttc     1200

ccctctcaga tgctgagaac gggcaacaac tttgagttca gctacagctt cgaggacgtg     1260

cctttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcccctcatc     1320

gaccagtact tgtactacct ggccagaaca cagagtaacc caggaggcac agctggcaat     1380

cgggaactgc agttttacca gggcgggcct tcaactatgg ccgaacaagc caagaattgg     1440

ttacctggac cttgcttccg gcaacaaaga gtctccaaaa cgctggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggcagaaa ctcgttggtt     1560

aatcccggcg tcgccatggc aactcacaag gacgacgagg accgcttttt cccatccagc     1620

ggagtcctga tttttggaaa aactggagca actaacaaaa ctacattgga aaatgtgtta     1680

atgacaaatg aagaagaaat tcgtcctact aatcctgtag ccacggaaga atacgggata     1740

gtcagcagca acttacaagc ggctaatact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggcatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga tggcaacttt cacccgtctc ctttgatggg cggctttgga     1920

cttaaacatc cgcctcctca gatcctgatc aagaacactc ccgttcccgc taatcctccg     1980

gaggtgttta ctcctgccaa gtttgcttcg ttcatcacac agtacagcac cggacaagtc     2040

agcgtggaaa tcgagtggga gctgcagaag gaaaacagca agcgctggaa cccggagatt     2100

cagtacacct ccaactttga aaagcagact ggtgtggact ttgccgttga cagccagggt     2160

gtttactctg agcctcgccc tattggcact cgttacctca cccgtaatct gtaa           2214


<210>  110
<211>  737
<212>  PRT
<213>  Adeno-associated virus 7

<400>  110

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Ala Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Val Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Glu Thr Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Pro Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Ser Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Thr Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Glu Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  111
<211>  2217
<212>  DNA
<213>  Adeno-associated virus 8

<400>  111
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaacctccag cagcgccctc tggtgtggga      600

cctaatacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggagccacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tttcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggag taccagctgc cgtacgttct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtgttca tgattcccca gtacggctac     1140

ctaacactca acaacggtag tcaggccgtg ggacgctcct ccttctactg cctggaatac     1200

tttccttcgc agatgctgag aaccggcaac aacttccagt ttacttacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcccacagc cagagcttgg accggctgat gaatcctctg     1320

attgaccagt acctgtacta cttgtctcgg actcaaacaa caggaggcac ggcaaatacg     1380

cagactctgg gcttcagcca aggtgggcct aatacaatgg ccaatcaggc aaagaactgg     1440

ctgccaggac cctgttaccg ccaacaacgc gtctcaacga caaccgggca aaacaacaat     1500

agcaactttg cctggactgc tgggaccaaa taccatctga atggaagaaa ttcattggct     1560

aatcctggca tcgctatggc aacacacaaa gacgacgagg agcgtttttt tcccagtaac     1620

gggatcctga tttttggcaa acaaaatgct gccagagaca atgcggatta cagcgatgtc     1680

atgctcacca gcgaggaaga aatcaaaacc actaaccctg tggctacaga ggaatacggt     1740

atcgtggcag ataacttgca gcagcaaaac acggctcctc aaattggaac tgtcaacagc     1800

cagggggcct tacccggtat ggtctggcag aaccgggacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccacccgt ctccgctgat gggcggcttt     1920

ggcctgaaac atcctccgcc tcagatcctg atcaagaaca cgcctgtacc tgcggatcct     1980

ccgaccacct tcaaccagtc aaagctgaac tctttcatca cgcaatacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca gcaagcgctg gaaccccgag     2100

atccagtaca cctccaacta ctacaaatct acaagtgtgg actttgctgt taatacagaa     2160

ggcgtgtact ctgaaccccg ccccattggc acccgttacc tcacccgtaa tctgtaa        2217


<210>  112
<211>  2213
<212>  DNA
<213>  Adeno-associated virus 8

<400>  112
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaacctccag cagcgccctc tggtgtggga      600

cctaatacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggagccacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tttcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggag taccagctgc cgtacgttct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtgttca tgattcccca gtacggctac     1140

ctaacactca acaacggtag tcaggccgtg ggacgctcct ccttctactg cctggaatac     1200

tttccttcgc agatgctgag aaccggcaac aacttccagt ttacttacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcccacagc cagagcttgg accggctgat gaatcctctg     1320

attgaccagt acctgtacta cttgtctcgg actcaaacaa caggaggcac ggcaaatacg     1380

cagactctgg gcttcagcca aggtgggcct aatacaatgg ccaatcaggc aaagaactgg     1440

ctgccaggac cctgttaccg ccaacaacgc gtctcaacga caaccgggca aaacaacaat     1500

agcaactttg cctggactgc tgggaccaaa taccatctga atggaagaaa ttcattggct     1560

aatcctggca tcgctatggc aacacacaaa gacgacgagg agcgtttttt tcccagtaac     1620

gggatcctga tttttggcaa acaaaatgct gccagagaca atgcggatta cagcgatgtc     1680

atgctcacca gcgaggaaga aatcaaaacc actaaccctg tggctacaga ggaatacggt     1740

atcgtggcag ataacttgca gcagcaaaac acggctcctc aaattggaac tgtcaacagc     1800

cagggggcct tacccggtat ggtctggcag aaccgggacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccacccgt ctccgctgat gggcggcttt     1920

ggcctgaaac atcctccgcc tcagatcctg atcaagaaca cgcctgtacc tgcggatcct     1980

ccgaccacct tcaaccagtc aaagctgaac tctttcatca cgcaatacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca gcaagcgctg gaaccccgag     2100

atccagtaca cctccaacta ctacaaatct acaagtgtgg actttgctgt aatacagaag     2160

gcgtgtactc tgaaccccgc cccattggca cccgttacct cacccgtaat ctg            2213


<210>  113
<211>  4393
<212>  DNA
<213>  Adeno-associated virus 8

<400>  113
cagagaggga gtggccaact ccatcactag gggtagcgcg aagcgcctcc cacgctgccg       60

cgtcagcgct gacgtaaatt acgtcatagg ggagtggtcc tgtattagct gtcacgtgag      120

tgcttttgcg gcattttgcg acaccacgtg gccatttgag gtatatatgg ccgagtgagc      180

gagcaggatc tccattttga ccgcgaaatt tgaacgagca gcagccatgc cgggcttcta      240

cgagatcgtg atcaaggtgc cgagcgacct ggacgagcac ctgccgggca tttctgactc      300

gtttgtgaac tgggtggccg agaaggaatg ggagctgccc ccggattctg acatggatcg      360

gaatctgatc gagcaggcac ccctgaccgt ggccgagaag ctgcagcgcg acttcctggt      420

ccaatggcgc cgcgtgagta aggccccgga ggccctcttc tttgttcagt tcgagaaggg      480

cgagagctac tttcacctgc acgttctggt cgagaccacg ggggtcaagt ccatggtgct      540

aggccgcttc ctgagtcaga ttcgggaaaa gcttggtcca gaccatctac ccgcggggtc      600

gagccccacc ttgcccaact ggttcgcggt gaccaaagac gcggtaatgg cgccggcggg      660

ggggaacaag gtggtggacg agtgctacat ccccaactac ctcctgccca agactcagcc      720

cgagctgcag tgggcgtgga ctaacatgga ggagtatata agcgcgtgct tgaacctggc      780

cgagcgcaaa cggctcgtgg cgcagcacct gacccacgtc agccagacgc aggagcagaa      840

caaggagaat ctgaacccca attctgacgc gcccgtgatc aggtcaaaaa cctccgcgcg      900

ctatatggag ctggtcgggt ggctggtgga ccggggcatc acctccgaga agcagtggat      960

ccaggaggac caggcctcgt acatctcctt caacgccgcc tccaactcgc ggtcccagat     1020

caaggccgcg ctggacaatg ccggcaagat catggcgctg accaaatccg cgcccgacta     1080

cctggtgggg ccctcgctgc ccgcggacat tacccagaac cgcatctacc gcatcctcgc     1140

tctcaacggc tacgaccctg cctacgccgg ctccgtcttt ctcggctggg ctcagaaaaa     1200

gttcgggaaa cgcaacacca tctggctgtt tggacccgcc accaccggca agaccaacat     1260

tgcggaagcc atcgcccacg ccgtgccctt ctacggctgc gtcaactgga ccaatgagaa     1320

ctttcccttc aatgattgcg tcgacaagat ggtgatctgg tgggaggagg gcaagatgac     1380

ggccaaggtc gtggagtccg ccaaggccat tctcggcggc agcaaggtgc gcgtggacca     1440

aaagtgcaag tcgtccgccc agatcgaccc cacccccgtg atcgtcacct ccaacaccaa     1500

catgtgcgcc gtgattgacg ggaacagcac caccttcgag caccagcagc ctctccagga     1560

ccggatgttt aagttcgaac tcacccgccg tctggagcac gactttggca aggtgacaaa     1620

gcaggaagtc aaagagttct tccgctgggc cagtgatcac gtgaccgagg tggcgcatga     1680

gttttacgtc agaaagggcg gagccagcaa aagacccgcc cccgatgacg cggataaaag     1740

cgagcccaag cgggcctgcc cctcagtcgc ggatccatcg acgtcagacg cggaaggagc     1800

tccggtggac tttgccgaca ggtaccaaaa caaatgttct cgtcacgcgg gcatgcttca     1860

gatgctgttt ccctgcaaaa cgtgcgagag aatgaatcag aatttcaaca tttgcttcac     1920

acacggggtc agagactgct cagagtgttt ccccggcgtg tcagaatctc aaccggtcgt     1980

cagaaagagg acgtatcgga aactctgtgc gattcatcat ctgctggggc gggctcccga     2040

gattgcttgc tcggcctgcg atctggtcaa cgtggacctg gatgactgtg tttctgagca     2100

ataaatgact taaaccaggt atggctgccg atggttatct tccagattgg ctcgaggaca     2160

acctctctga gggcattcgc gagtggtggg cgctgaaacc tggagccccg aagcccaaag     2220

ccaaccagca aaagcaggac gacggccggg gtctggtgct tcctggctac aagtacctcg     2280

gacccttcaa cggactcgac aagggggagc ccgtcaacgc ggcggacgca gcggccctcg     2340

agcacgacaa ggcctacgac cagcagctgc aggcgggtga caatccgtac ctgcggtata     2400

accacgccga cgccgagttt caggagcgtc tgcaagaaga tacgtctttt gggggcaacc     2460

tcgggcgagc agtcttccag gccaagaagc gggttctcga acctctcggt ctggttgagg     2520

aaggcgctaa gacggctcct ggaaagaaga gaccggtaga gccatcaccc cagcgttctc     2580

cagactcctc tacgggcatc ggcaagaaag gccaacagcc cgccagaaaa agactcaatt     2640

ttggtcagac tggcgactca gagtcagttc cagaccctca acctctcgga gaacctccag     2700

cagcgccctc tggtgtggga cctaatacaa tggctgcagg cggtggcgca ccaatggcag     2760

acaataacga aggcgccgac ggagtgggta gttcctcggg aaattggcat tgcgattcca     2820

catggctggg cgacagagtc atcaccacca gcacccgaac ctgggccctg cccacctaca     2880

acaaccacct ctacaagcaa atctccaacg ggacatcggg aggagccacc aacgacaaca     2940

cctacttcgg ctacagcacc ccctgggggt attttgactt taacagattc cactgccact     3000

tttcaccacg tgactggcag cgactcatca acaacaactg gggattccgg cccaagagac     3060

tcagcttcaa gctcttcaac atccaggtca aggaggtcac gcagaatgaa ggcaccaaga     3120

ccatcgccaa taacctcacc agcaccatcc aggtgtttac ggactcggag taccagctgc     3180

cgtacgttct cggctctgcc caccagggct gcctgcctcc gttcccggcg gacgtgttca     3240

tgattcccca gtacggctac ctaacactca acaacggtag tcaggccgtg ggacgctcct     3300

ccttctactg cctggaatac tttccttcgc agatgctgag aaccggcaac aacttccagt     3360

ttacttacac cttcgaggac gtgcctttcc acagcagcta cgcccacagc cagagcttgg     3420

accggctgat gaatcctctg attgaccagt acctgtacta cttgtctcgg actcaaacaa     3480

caggaggcac ggcaaatacg cagactctgg gcttcagcca aggtgggcct aatacaatgg     3540

ccaatcaggc aaagaactgg ctgccaggac cctgttaccg ccaacaacgc gtctcaacga     3600

caaccgggca aaacaacaat agcaactttg cctggactgc tgggaccaaa taccatctga     3660

atggaagaaa ttcattggct aatcctggca tcgctatggc aacacacaaa gacgacgagg     3720

agcgtttttt tcccagtaac gggatcctga tttttggcaa acaaaatgct gccagagaca     3780

atgcggatta cagcgatgtc atgctcacca gcgaggaaga aatcaaaacc actaaccctg     3840

tggctacaga ggaatacggt atcgtggcag ataacttgca gcagcaaaac acggctcctc     3900

aaattggaac tgtcaacagc cagggggcct tacccggtat ggtctggcag aaccgggacg     3960

tgtacctgca gggtcccatc tgggccaaga ttcctcacac ggacggcaac ttccacccgt     4020

ctccgctgat gggcggcttt ggcctgaaac atcctccgcc tcagatcctg atcaagaaca     4080

cgcctgtacc tgcggatcct ccgaccacct tcaaccagtc aaagctgaac tctttcatca     4140

cgcaatacag caccggacag gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca     4200

gcaagcgctg gaaccccgag atccagtaca cctccaacta ctacaaatct acaagtgtgg     4260

actttgctgt taatacagaa ggcgtgtact ctgaaccccg ccccattggc acccgttacc     4320

tcacccgtaa tctgtaattg cctgttaatc aataaaccgg ttgattcgtt tcagttgaac     4380

tttggtctct gcg                                                        4393


<210>  114
<211>  738
<212>  PRT
<213>  Adeno-associated virus 8

<400>  114

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  115
<211>  737
<212>  PRT
<213>  Adeno-associated virus 8

<400>  115

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Ile Gln Lys 
705                 710                 715                 720 


Ala Cys Thr Leu Asn Pro Ala Pro Leu Ala Pro Val Thr Ser Pro Val 
                725                 730                 735     


Ile 
    


<210>  116
<211>  2217
<212>  DNA
<213>  Adeno-associated virus 8

<400>  116
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaacctccag cagcgccctc tggtgtggga      600

cctaatacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggagccacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tttcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggag taccagctgc cgtacgttct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtgttca tgattcccca gtacggctac     1140

ctaacactca acaacggtag tcaggccgtg ggacgctcct ccttctactg cctggaatac     1200

tttccttcgc agatgctgag aaccggcaac aacttccagt ttacttacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcccacagc cagagcttgg accggctgat gaatcctctg     1320

attgaccagt acctgtacta cttgtctcgg actcaaacaa caggaggcac ggcaaatacg     1380

cagactctgg gcttcagcca aggtgggcct aatacaatgg ccaatcaggc aaagaactgg     1440

ctgccaggac cctgttaccg ccaacaacgc gtctcaacga caaccgggca aaacaacaat     1500

agcaactttg cctggactgc tgggaccaaa taccatctga atggaagaaa ttcattggct     1560

aatcctggca tcgctatggc aacacacaaa gacgacgagg agcgtttttt tcccagtaac     1620

gggatcctga tttttggcaa acaaaatgct gccagagaca atgcggatta cagcgatgtc     1680

atgctcacca gcgaggaaga aatcaaaacc actaaccctg tggctacaga ggaatacggt     1740

atcgtggcag ataacttgca gcagcaaaac acggctcctc aaattggaac tgtcaacagc     1800

cagggggcct tacccggtat ggtctggcag aaccgggacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccacccgt ctccgctgat gggcggcttt     1920

ggcctgaaac atcctccgcc tcagatcctg atcaagaaca cgcctgtacc tgcggatcct     1980

ccgaccacct tcaaccagtc aaagctgaac tctttcatca cgcaatacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca gcaagcgctg gaaccccgag     2100

atccagtaca cctccaacta ctacaaatct acaagtgtgg actttgctgt taatacagaa     2160

ggcgtgtact ctgaaccccg ccccattggc acccgttacc tcacccgtaa tctgtaa        2217


<210>  117
<211>  2214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  117
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaacctccag cagcgccctc tggtgtggga      600

cctaatacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggagccacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tttcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggag taccagctgc cgtacgttct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtgttca tgattcccca gtacggctac     1140

ctaacactca acaacggtag tcaggccgtg ggacgctcct ccttctactg cctggaatac     1200

tttccttcgc agatgctgag aaccggcaac aacttccagt ttacttacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcccacagc cagagcttgg accggctgat gaatcctctg     1320

attgaccagt acctgtacta cttgtctcgg actcaaacaa caggaggcac ggcaaatacg     1380

cagactctgg gcttcagcca aggtgggcct aatacaatgg ccaatcaggc aaagaactgg     1440

ctgccaggac cctgttaccg ccaacaacgc gtctcaacga caaccgggca aaacaacaat     1500

agcaactttg cctggactgc tgggaccaaa taccatctga atggaagaaa ttcattggct     1560

aatcctggca tcgctatggc aacacacaaa gacgacgagg agcgtttttt tcccagtaac     1620

gggatcctga tttttggcaa acaaaatgct gccagagaca atgcggatta cagcgatgtc     1680

atgctcacca gcgaggaaga aatcaaaacc actaaccctg tggctacaga ggaatacggt     1740

atcgtggcag ataacttgcc tgagcggacg gcgatgagtc ttccgggaac tgtcaacagc     1800

cagggggcct tacccggtat ggtctggcag aaccgggacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccacccgt ctccgctgat gggcggcttt     1920

ggcctgaaac atcctccgcc tcagatcctg atcaagaaca cgcctgtacc tgcggatcct     1980

ccgaccacct tcaaccagtc aaagctgaac tctttcatca cgcaatacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca gcaagcgctg gaaccccgag     2100

atccagtaca cctccaacta ctacaaatct acaagtgtgg actttgctgt taatacagaa     2160

ggcgtgtact ctgaaccccg ccccattggc acccgttacc tcacccgtaa tctg           2214


<210>  118
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  118

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Pro Glu Arg Thr Ala Met 
            580                 585                 590         


Ser Leu Pro Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  119
<211>  2214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  119
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaacctccag cagcgccctc tggtgtggga      600

cctaatacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggagccacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tttcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggag taccagctgc cgtacgttct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtgttca tgattcccca gtacggctac     1140

ctaacactca acaacggtag tcaggccgtg ggacgctcct ccttctactg cctggaatac     1200

tttccttcgc agatgctgag aaccggcaac aacttccagt ttacttacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcccacagc cagagcttgg accggctgat gaatcctctg     1320

attgaccagt acctgtacta cttgtctcgg actcaaacaa caggaggcac ggcaaatacg     1380

cagactctgg gcttcagcca aggtgggcct aatacaatgg ccaatcaggc aaagaactgg     1440

ctgccaggac cctgttaccg ccaacaacgc gtctcaacga caaccgggca aaacaacaat     1500

agcaactttg cctggactgc tgggaccaaa taccatctga atggaagaaa ttcattggct     1560

aatcctggca tcgctatggc aacacacaaa gacgacgagg agcgtttttt tcccagtaac     1620

gggatcctga tttttggcaa acaaaatgct gccagagaca atgcggatta cagcgatgtc     1680

atgctcacca gcgaggaaga aatcaaaacc actaaccctg tggctacaga ggaatacggt     1740

atcgtggcag ataacttgag ttttagtcgt gcggttcttt gtgatggaac tgtcaacagc     1800

cagggggcct tacccggtat ggtctggcag aaccgggacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccacccgt ctccgctgat gggcggcttt     1920

ggcctgaaac atcctccgcc tcagatcctg atcaagaaca cgcctgtacc tgcggatcct     1980

ccgaccacct tcaaccagtc aaagctgaac tctttcatca cgcaatacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca gcaagcgctg gaaccccgag     2100

atccagtaca cctccaacta ctacaaatct acaagtgtgg actttgctgt taatacagaa     2160

ggcgtgtact ctgaaccccg ccccattggc acccgttacc tcacccgtaa tctg           2214


<210>  120
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  120

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Ser Phe Ser Arg Ala Val 
            580                 585                 590         


Leu Cys Asp Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  121
<211>  4385
<212>  DNA
<213>  Adeno-associated virus 9

<400>  121
cagagaggga gtggccaact ccatcactag gggtaatcgc gaagcgcctc ccacgctgcc       60

gcgtcagcgc tgacgtagat tacgtcatag gggagtggtc ctgtattagc tgtcacgtga      120

gtgcttttgc gacattttgc gacaccacat ggccatttga ggtatatatg gccgagtgag      180

cgagcaggat ctccattttg accgcgaaat ttgaacgagc agcagccatg ccgggcttct      240

acgagattgt gatcaaggtg ccgagcgacc tggacgagca cctgccgggc atttctgact      300

cttttgtgaa ctgggtggcc gagaaggaat gggagctgcc cccggattct gacatggatc      360

ggaatctgat cgagcaggca cccctgaccg tggccgagaa gctgcagcgc gacttcctgg      420

tccaatggcg ccgcgtgagt aaggccccgg aggccctctt ctttgttcag ttcgagaagg      480

gcgagagcta ctttcacctg cacgttctgg tcgagaccac gggggtcaag tccatggtgc      540

taggccgctt cctgagtcag attcgggaga agctggtcca gaccatctac cgcgggatcg      600

agccgaccct gcccaactgg ttcgcggtga ccaagacgcg taatggcgcc ggcgggggga      660

acaaggtggt ggacgagtgc tacatcccca actacctcct gcccaagact cagcccgagc      720

tgcagtgggc gtggactaac atggaggagt atataagcgc gtgcttgaac ctggccgagc      780

gcaaacggct cgtggcgcag cacctgaccc acgtcagcca gacgcaggag cagaacaagg      840

agaatctgaa ccccaattct gacgcgcccg tgatcaggtc aaaaacctcc gcgcgctaca      900

tggagctggt cgggtggctg gtggaccggg gcatcacctc cgagaagcag tggatccagg      960

aggaccaggc ctcgtacatc tccttcaacg ccgcctccaa ctcgcggtcc cagatcaagg     1020

ccgcgctgga caatgccggc aagatcatgg cgctgaccaa atccgcgccc gactacctgg     1080

taggcccttc acttccggtg gacattacgc agaaccgcat ctaccgcatc ctgcagctca     1140

acggctacga ccctgcctac gccggctccg tctttctcgg ctgggcacaa aagaagttcg     1200

ggaaacgcaa caccatctgg ctgtttgggc cggccaccac gggaaagacc aacatcgcag     1260

aagccattgc ccacgccgtg cccttctacg gctgcgtcaa ctggaccaat gagaactttc     1320

ccttcaacga ttgcgtcgac aagatggtga tctggtggga ggagggcaag atgacggcca     1380

aggtcgtgga gtccgccaag gccattctcg gcggcagcaa ggtgcgcgtg gaccaaaagt     1440

gcaagtcgtc cgcccagatc gaccccactc ccgtgatcgt cacctccaac accaacatgt     1500

gcgccgtgat tgacgggaac agcaccacct tcgagcacca gcagcctctc caggaccgga     1560

tgtttaagtt cgaactcacc cgccgtctgg agcacgactt tggcaaggtg acaaagcagg     1620

aagtcaaaga gttcttccgc tgggccagtg atcacgtgac cgaggtggcg catgagtttt     1680

acgtcagaaa gggcggagcc agcaaaagac ccgcccccga tgacgcggat aaaagcgagc     1740

ccaagcgggc ctgcccctca gtcgcggatc catcgacgtc agacgcggaa ggagctccgg     1800

tggactttgc cgacaggtac caaaacaaat gttctcgtca cgcgggcatg cttcagatgc     1860

tgcttccctg caaaacgtgc gagagaatga atcagaattt caacatttgc ttcacacacg     1920

gggtcagaga ctgctcagag tgtttccccg gcgtgtcaga atctcaaccg gtcgtcagaa     1980

agaggacgta tcggaaactc tgtgcgattc atcatctgct ggggcgggct cccgagattg     2040

cttgctcggc ctgcgatctg gtcaacgtgg acctggatga ctgtgtttct gagcaataaa     2100

tgacttaaac caggtatggc tgccgatggt tatcttccag attggctcga ggacaacctc     2160

tctgagggca ttcgcgagtg gtgggcgctg aaacctggag ccccgaagcc caaagccaac     2220

cagcaaaagc aggacgacgg ccggggtctg gtgcttcctg gctacaagta cctcggaccc     2280

ttcaacggac tcgacaaggg ggagcccgtc aacgcggcgg acgcagcggc cctcgagcac     2340

ggcaaggcct acgaccagca gctgcaggcg ggtgacaatc cgtacctgcg gtataaccac     2400

gccgacgccg agtttcagga gcgtctgcaa gaagatacgt cttttggggg caacctcggg     2460

cgagcagtct tccaggccaa gaagcgggtt ctcgaacctc tcggtctggt tgaggaaggc     2520

gctaagacgg ctcctggaaa gaagagaccg gtagagccat caccccagcg ttctccagac     2580

tcctctacgg gcatcggcaa gaaaggccaa cagcccgcca gaaaaagact caattttggt     2640

cagactggcg actcagagtc agttccagac cctcaacctc tcggagaacc tccagcagcg     2700

ccctctggtg tgggacctaa tacaatggct gcaggcggtg gcgcaccaat ggcagacaat     2760

aacgaaggcg ccgacggagt gggtaattcc tcgggaaatt ggcattgcga ttccacatgg     2820

ctgggggaca gagtcatcac caccagcacc cgaacctggg cattgcccac ctacaacaac     2880

cacctctaca agcaaatctc caatggaaca tcgggaggaa gcaccaacga caacacctac     2940

tttggctaca gcaccccctg ggggtatttt gacttcaaca gattccactg ccacttctca     3000

ccacgtgact ggcagcgact catcaacaac aactggggat tccggccaaa gagactcaac     3060

ttcaagctgt tcaacatcca ggtcaaggag gttacgacga acgaaggcac caagaccatc     3120

gccaataacc ttaccagcac cgtccaggtc tttacggact cggagtacca gctaccgtac     3180

gtcctaggct ctgcccacca aggatgcctg ccaccgtttc ctgcagacgt cttcatggtt     3240

cctcagtacg gctacctgac gctcaacaat ggaagtcaag cgttaggacg ttcttctttc     3300

tactgtctgg aatacttccc ttctcagatg ctgagaaccg gcaacaactt tcagttcagc     3360

tacactttcg aggacgtgcc tttccacagc agctacgcac acagccagag tctagatcga     3420

ctgatgaacc ccctcatcga ccagtaccta tactacctgg tcagaacaca gacaactgga     3480

actgggggaa ctcaaacttt ggcattcagc caagcaggcc ctagctcaat ggccaatcag     3540

gctagaaact gggtacccgg gccttgctac cgtcagcagc gcgtctccac aaccaccaac     3600

caaaataaca acagcaactt tgcgtggacg ggagctgcta aattcaagct gaacgggaga     3660

gactcgctaa tgaatcctgg cgtggctatg gcatcgcaca aagacgacga ggaccgcttc     3720

tttccatcaa gtggcgttct catatttggc aagcaaggag ccgggaacga tggagtcgac     3780

tacagccagg tgctgattac agatgaggaa gaaattaaag ccaccaaccc tgtagccaca     3840

gaggaatacg gagcagtggc catcaacaac caggccgcta acacgcaggc gcaaactgga     3900

cttgtgcata accagggagt tattcctggt atggtctggc agaaccggga cgtgtacctg     3960

cagggcccta tttgggctaa aatacctcac acagatggca actttcaccc gtctcctctg     4020

atgggtggat ttggactgaa acacccacct ccacagattc taattaaaaa tacaccagtg     4080

ccggcagatc ctcctcttac cttcaatcaa gccaagctga actctttcat cacgcagtac     4140

agcacgggac aagtcagcgt ggaaatcgag tgggagctgc agaaagaaaa cagcaagcgc     4200

tggaatccag agatccagta tacttcaaac tactacaaat ctacaaatgt ggactttgct     4260

gtcaatacca aaggtgttta ctctgagcct cgccccattg gtactcgtta cctcacccgt     4320

aatttgtaat tgcctgttaa tcaataaacc ggttaattcg tttcagttga actttggtct     4380

ctgcg                                                                 4385


<210>  122
<211>  4382
<212>  DNA
<213>  Adeno-associated virus 9

<400>  122
cagagaggga gtggccaact ccatcactag gggtaatcgc gaagcgcctc ccacgctgcc       60

gcgtcagcgc tgacgtagat tacgtcatag gggagtggtc ctgtattagc tgtcacgtga      120

gtgcttttgc gacattttgc gacaccacat ggccatttga ggtatatatg gccgagtgag      180

cgagcaggat ctccattttg accgcgaaat ttgaacgagc agcagccatg ccgggcttct      240

acgagattgt gatcaaggtg ccgagcgacc tggacgagca cctgccgggc atttctgact      300

cttttgtgaa ctgggtggcc gagaaggaat gggagctgcc cccggattct gacatggatc      360

ggaatctgat cgagcaggca cccctgaccg tggccgagaa gctgtagcgc gacttcctgg      420

tccaatggcg ccgcgtgagt aaggccccgg aggccctctt ctttgttcag ttcgagaagg      480

gcgagagcta ctttcacctg cacgttctgg tcgagaccac gggggtcaag tccatggtgc      540

taggccgctt cctgagtcag attcgggaga agctggtcca gaccatctac cgcgggatcg      600

agccgaccct gcccaactgg ttcgcggtga ccaagacgcg taatggcgcc ggcgggggga      660

acaaggtggt ggacgagtgc tacatcccca actacctcct gcccaagact cagcccgagc      720

tgcagtgggc gtggactaac atggaggagt atataagcgc gtgcttgaac ctggccgagc      780

gcaaacggct cgtggcgcag cacctgaccc acgtcagcca gacgcaggag cagaacaagg      840

agaatctgaa ccccaattct gacgcgcccg tgatcaggtc aaaaacctcc gcgcgctaca      900

tggagctggt cgggtggctg gtggaccggg gcatcacctc cgagaagcag tggatccagg      960

aggaccaggc ctcgtacatc tccttcaacg ccgcctccaa ctcgcggtcc cagatcaagg     1020

ccgcgctgga caatgccggc aagatcatgg cgctgaccaa atccgcgccc gactacctgg     1080

taggcccttc acttccggtg gacattacgc agaaccgcat ctaccgcatc ctgcagctca     1140

acggctacga ccctgcctac gccggctccg tctttctcgg ctgggcacaa aagaagttcg     1200

ggaaacgcaa caccatctgg ctgtttgggc cggccaccac gggaaagacc aacatcgcag     1260

aagccattgc ccacgccgtg cccttctacg gctgcgtcaa ctggaccaat gagaactttc     1320

ccttcaacga ttgcgtcgac aagatggtga tctggtggga ggagggcaag atgacggcca     1380

aggtcgtgga gtccgccaag gccattctcg gcggcagcaa ggtgcgcgtg gaccaaaagt     1440

gcaagtcgtc cgcccagatc gaccccactc ccgtgatcgt cacctccaac accaacatgt     1500

gcgccgtgat tgacgggaac agcaccacct tcgagcacca gcagcctctc caggaccgga     1560

tgtttaagtt cgaactcacc cgccgtctgg agcacgactt tggcaaggtg acaaagcagg     1620

aagtcaaaga gttcttccgc tgggccagtg atcacgtgac cgaggtggcg catgagtttt     1680

acgtcagaaa gggcggagcc agcaaaagac ccgcccccga tgacgcggat aaaagcgagc     1740

ccaagcgggc ctgcccctca gtcgcggatc catcgacgtc agacgcggaa ggagctccgg     1800

tggactttgc cgacaggtac caaaacaaat gttctcgtca cgcgggcatg cttcagatgc     1860

tgcttccctg caaaacgtgc gagagaatga atcagaattt caacatttgc ttcacacacg     1920

gggtcagaga ctgctcagag tgtttccccg gcgtgtcaga atctcaaccg gtcgtcagaa     1980

agaggacgta tcggaaactc tgtgcgattc atcatctgct ggggcgggct cccgagattg     2040

cttgctcggc ctgcgatctg gtcaacgtgg acctggatga ctgtgtttct gagcaataaa     2100

tgacttaaac caggtatggc tgccgatggt tatcttccag attggctcga ggacaacctc     2160

tctgagggca ttcgcgagtg gtgggacctg aaacctggag ccccgaaacc caaagccaac     2220

cagcaaaagc aggacgacgg ccggggtctg gtgcttcctg gctacaagta cctcggaccc     2280

ttcaacggac tcgacaaggg ggagcccgtc aacgcggcgg acgcagcggc cctcgagcac     2340

gacaaggcct acgaccagca gctcaaagcg ggtgacaatc cgtacctgcg gtataaccac     2400

gccgacgccg agtttcagga gcgtctgcaa gaagatacgt cttttggggg caacctcggg     2460

cgagcagtct tccaggccaa gaagcgggtt ctcgaacctc tcggtctggt tgaggaaggc     2520

gctaagacgg ctcctggaaa gaagagaccg gtagagcagt caccccaaga accagactca     2580

tcctcgggca tcggcaaatc aggccagcag cccgctaaaa agagactcaa ttttggtcag     2640

actggcgact cagagtcagt ccccgaccca caacctctcg gagaacctcc agaagccccc     2700

tcaggtctgg gacctaatac aatggcttca ggcggtggcg ctccaatggc agacaataac     2760

gaaggcgccg acggagtggg taattcctcg ggaaattggc attgcgattc cacatggctg     2820

ggggacagag tcatcaccac cagcacccga acctgggcat tgcccaccta caacaaccac     2880

ctctacaagc aaatctccaa tggaacatcg ggaggaagca ccaacgacaa cacctacttt     2940

ggctacagca ccccctgggg gtattttgac ttcaacagat tccactgcca cttctcacca     3000

cgtgactggc agcgactcat caacaacaac tggggattcc ggccaaagag actcaacttc     3060

aagctgttca acatccaggt caaggaggtt acgacgaacg aaggcaccaa gaccatcgcc     3120

aataacctta ccagcaccgt ccaggtcttt acggactcgg agtaccagct accgtacgtc     3180

ctaggctctg cccaccaagg atgcctgcca ccgtttcctg cagacgtctt catggttcct     3240

cagtacggct acctgacgct caacaatgga agtcaagcgt taggacgttc ttctttctac     3300

tgtctggaat acttcccttc tcagatgctg agaaccggca acaactttca gttcagctac     3360

actttcgagg acgtgccttt ccacagcagc tacgcacaca gccagagtct agatcgactg     3420

atgaaccccc tcatcgacca gtacctatac tacctggtca gaacacagac aactggaact     3480

gggggaactc aaactttggc attcagccaa gcaggcccta gctcaatggc caatcaggct     3540

agaaactggg tacccgggcc ttgctaccgt cagcagcgcg tctccacaac caccaaccaa     3600

aataacaaca gcaactttgc gtggacggga gctgctaaat tcaagctgaa cgggagagac     3660

tcgctaatga atcctggcgt ggctatggca tcgcacaaag acgacgagga ccgcttcttt     3720

ccatcaagtg gcgttctcat atttggcaag caaggagccg ggaacgatgg agtcgactac     3780

agccaggtgc tgattacaga tgaggaagaa attaaagcca ccaaccctgt agccacagag     3840

gaatacggag cagtggccat caacaaccag gccgctaaca cgcaggcgca aactggactt     3900

gtgcataacc agggagttat tcctggtatg gtctggcaga accgggacgt gtacctgcag     3960

ggccctattt gggctaaaat acctcacaca gatggcaact ttcacccgtc tcctctgatg     4020

ggtggatttg gactgaaaca cccacctcca cagattctaa ttaaaaatac accagtgccg     4080

gcagatcctc ctcttacctt caatcaagcc aagctgaact ctttcatcac gcagtacagc     4140

acgggacaag tcagcgtgga aatcgagtgg gagctgcaga aagaaaacag caagcgctgg     4200

aatccagaga tccagtatac ttcaaactac tacaaatcta caaatgtgga ctttgctgtc     4260

aataccgaag gtgtttactc tgagcctcgc cccattggta ctcgttacct cacccgtaat     4320

ttgtaattgc ctgttaatca ataaaccggt taattcgttt cagttgaact ttggtctctg     4380

cg                                                                    4382


<210>  123
<211>  736
<212>  PRT
<213>  Adeno-associated virus 9

<400>  123

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  124
<211>  736
<212>  PRT
<213>  Adeno-associated virus 9

<400>  124

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Glu Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  125
<211>  623
<212>  PRT
<213>  Adeno-associated virus 9

<400>  125

Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Arg Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Val Gln Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Leu His Val Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Glu Lys Leu Val Gln Thr Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Glu Tyr Ile 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Leu Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ala Leu Thr Lys Ser Ala Pro Asp Tyr Leu Val Gly Pro Ser 
        275                 280                 285             


Leu Pro Val Asp Ile Thr Gln Asn Arg Ile Tyr Arg Ile Leu Gln Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Ala Tyr Ala Gly Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Gln Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Glu His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Glu Phe Phe Arg Trp Ala Ser Asp His Val Thr Glu Val 
465                 470                 475                 480 


Ala His Glu Phe Tyr Val Arg Lys Gly Gly Ala Ser Lys Arg Pro Ala 
                485                 490                 495     


Pro Asp Asp Ala Asp Lys Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 
            500                 505                 510         


Ala Asp Pro Ser Thr Ser Asp Ala Glu Gly Ala Pro Val Asp Phe Ala 
        515                 520                 525             


Asp Arg Tyr Gln Asn Lys Cys Ser Arg His Ala Gly Met Leu Gln Met 
    530                 535                 540                 


Leu Leu Pro Cys Lys Thr Cys Glu Arg Met Asn Gln Asn Phe Asn Ile 
545                 550                 555                 560 


Cys Phe Thr His Gly Val Arg Asp Cys Ser Glu Cys Phe Pro Gly Val 
                565                 570                 575     


Ser Glu Ser Gln Pro Val Val Arg Lys Arg Thr Tyr Arg Lys Leu Cys 
            580                 585                 590         


Ala Ile His His Leu Leu Gly Arg Ala Pro Glu Ile Ala Cys Ser Ala 
        595                 600                 605             


Cys Asp Leu Val Asn Val Asp Leu Asp Asp Cys Val Ser Glu Gln 
    610                 615                 620             


<210>  126
<211>  2211
<212>  DNA
<213>  Adeno-associated virus

<400>  126
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     1140

acgcttaatg atggaagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     1320

gaccaatact tgtactatct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gtgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtgc ccaagcacag gcgcagaccg gctgggttca aaaccaagga     1800

atacttccgg gtatggtttg gcaggacaga gatgtgtacc tgcaaggacc catttgggcc     1860

aaaattcctc acacggacgg caactttcac ccttctccgc tgatgggagg gtttggaatg     1920

aagcacccgc ctcctcagat cctcatcaaa aacacacctg tacctgcgga tcctccaacg     1980

gccttcaaca aggacaagct gaactctttc atcacccagt attctactgg ccaagtcagc     2040

gtggagatcg agtgggagct gcagaaggaa aacagcaagc gctggaaccc ggagatccag     2100

tacacttcca actattacaa gtctaataat gttgaatttg ctgttaatac tgaaggtgta     2160

tatagtgaac cccgccccat tggcaccaga tacctgactc gtaatctgta a              2211


<210>  127
<211>  736
<212>  PRT
<213>  Adeno-associated virus

<400>  127

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  128
<211>  2460
<212>  DNA
<213>  Adeno-associated virus

<400>  128
ggtaattcct ccggaaattg gcattgcgat tccacatggc tgggcgaccg agtcattacc       60

accagcaccc ggacttgggc cctgcccacc tacaacaacc acctctacaa gcaaatctcc      120

agccaatcgg gtgccaccaa cgacaaccac tacttcggct acagcacccc ttgggggtat      180

tttgatttca acagattcca ctgccatttc tcaccacgtg actggcagcg actcatcaac      240

aacaactggg gattcatggc tgccgatggt tatcttccag attggctcga ggacactctc      300

tctgaaggaa tcagacagtg gtggaagctc aaacctggcc caccaccgcc gaaacctaac      360

caacaacacc gggacgacag taggggtctt gtgcttcctg ggtacaagta cctcggaccc      420

ttcaacggac tcgacaaagg agagccggtc aacgaggcag acgccgcggc cctcgagcac      480

gacaaagcct acgaccacca gctcaagcaa ggggacaacc cgtacctcaa atacaaccac      540

gcggacgctg aatttcagga gcgtcttcaa gaagatacgt ctttcggggg caacctcggg      600

cgagcagtct tccaggccaa aaagagggta ctcgagcctc ttggtctggt tgaggaagct      660

gttaagacgg ctcctggaaa aaagagacct atagagcagt ctcctgcaga accggactct      720

tcctcgggca tcggcaaatc aggccagcag cccgctaaga aaagactcaa ttttggtcag      780

actggcgaca cagagtcagt cccagaccct caaccaatcg gagaaccccc cgcagccccc      840

tctggtgtgg gatctaatac aatggcttca ggcggtgggg caccaatggc agacaataac      900

gaaggcgccg acggagtggg taattcctcg ggaaattggc attgcgattc cacatggatg      960

ggcgacagag ttatcaccac cagcacaaga acctgggccc tccccaccta caataatcac     1020

ctctacaagc aaatctccag cgaatcggga gccaccaacg acaaccacta cttcggctac     1080

agcaccccct gggggtattt tgactttaac agattccact gtcacttctc accacgtgac     1140

tggcagcgac tcatcaacaa caactgggga tttagaccca agaaactcaa tttcaagctc     1200

ttcaacatcc aagtcaagga ggtcacgcag aatgatggaa ccacgaccat cgccaataac     1260

cttaccagca cggtgcaggt cttcacagac tctgagtacc agctgcccta cgtcctcggt     1320

tcggctcacc agggctgcct tccgccgttc ccagcagacg tcttcatgat tcctcagtac     1380

ggctacttga ctctgaacaa tggcagccaa gcggtaggac gttcttcatt ctactgtcta     1440

gagtattttc cctctcagat gctgaggacg ggaaacaact tcaccttcag ctacactttt     1500

gaagacgtgc ctttccacag cagctacgcg cacagccaga gtctggatcg gctgatgaat     1560

cctctcattg accagtacct gtattacctg agcaaaactc agggtacaag tggaacaacg     1620

cagcaatcga gactgcagtt cagccaagct gggcctagct ccatggctca gcaggccaaa     1680

aactggctac cgggacccag ctaccgacag cagcgaatgt ctaagacggc taatgacaac     1740

aacaacagtg aatttgcttg gactgcagcc accaaatatt acctgaatgg aagaaattct     1800

ctggtcaatc ccgggccccc aatggccagt cacaaggacg atgaggaaaa gtatttcccc     1860

atgcacggaa atctcatctt tggaaaacaa ggcacaggaa ctaccaatgt ggacattgaa     1920

tcagtgctta ttacagacga agaagaaatc agaacaacta atcctgtggc tacagaacaa     1980

tacggacagg ttgccaccaa ccatcagagt cagaacacca cagcttccta tggaagtgtg     2040

gacagccagg gaatcttacc tggaatggtg tggcaggacc gcgatgtcta tcttcaaggt     2100

cccatttggg ccaaaactcc tcacacggac ggacactttc atccttctcc gctcatggga     2160

ggctttggac tgaaacaccc tcctccccag atcctgatca aaaacacacc tgtgccagcg     2220

aatcccgcga ccactttcac tcctggaaag tttgcttcgt tcattaccca gtattccacc     2280

ggacaggtca gcgtggaaat agagtgggag ctgcagaaag aaaacagcaa acgctggaac     2340

ccagaaattc agtacacctc caactacaac aagtcggtga atgtggagtt taccgtggac     2400

gcaaacggtg tttattctga accccgccct attggcactc gttaccttac ccggaacttg     2460


<210>  129
<211>  3123
<212>  DNA
<213>  Adeno-associated virus

<400>  129
gaattcgccc tttctacggc tgcgtcaact ggaccaatga aaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggaaagat gaccgccaag gtcgtggaat      120

ctgccaaagc cattctgggt ggaggcaagg ttcgtgtgga ccagaaatgc aagtcttcgg      180

cccagatcga cccgactccg gtgattgtca cctctaacac caacatgtgc gccgtgattg      240

acggaaactc gaccaccttc gagcaccagc agccgttgca agaccggatg ttcaaatttg      300

aacttacccg ccgtttggat catgactttg ggaaggtcac caagcaggaa gtcaaagact      360

ttttccggtg ggctcaagat cacgtgactg aggtggagca tgagttctac gtcaaaaagg      420

gtggagccaa gaaaaggccc gcccccgatg atgtatatat aaatgagccc aagcgggcgc      480

gcgagtcagt tgcgcagcca tcgacgtcag acgcggaagc ttcgataaac tacgcggaca      540

ggtaccaaaa caaatgttct cgtcacgtgg gcatgaatct gatgctgttt ccctgtcgac      600

aatgcgaaag aatgaatcag aattcaaata tctgcttcac acacgggcaa aaagactgtt      660

tggaatgctt tcccgtgtca gaatctcaac ccgtttctgt cgtcagaaaa acgtatcaga      720

aactttgtta cattcatcat atcatgggaa aagtaccaga cgcctgcact gcctgcgacc      780

tggtaaatgt ggacttggat gactgtattt ctgagcaata aatgacttaa atcaggtatg      840

gctgctgacg gttatcttcc agattggctc gaggacactc tctctgaagg aatcagacag      900

tggtggaagc tcaaacctgg cccaccaccg ccgaaaccta accaacaaca ccgggacgac      960

agtaggggtc ttgtgcttcc tgggtacaag tacctcggac ccttcaacgg actcgacaaa     1020

ggagagccgg tcaacgaggc agacgccgcg gccctcgagc acgacaaagc ctacgaccac     1080

cagctcaagc aaggggacaa cccgtacctc aaatacaacc acgcggacgc tgaatttcag     1140

gagcgtcttc aagaagatac gtctttcggg ggcaacctcg ggcgagcagt cttccaggcc     1200

aaaaagaggg tactcgagcc tcttggtctg gttgaggaag ctgttaagac ggctcctgga     1260

aaaaagagac ctatagagca gtctcctgca gaaccggact cttcctcggg catcggcaaa     1320

tcaggccagc agcccgctaa gaaaagactc aattttggtc agactggcga cacagagtca     1380

gtcccaggcc ctcaaccaat cggagaaccc cccgcagccc cctctggtgt gggatctaat     1440

acaatggctt caggcggtgg ggcaccaatg gcagacaata acgaaggcgc cgacggagtg     1500

ggtaattcct cgggaaattg gcattgcgat tccacatgga tgggcgacag agttatcacc     1560

accagcacaa gaacctgggc cctccccacc tacaataatc acctctacaa gcaaatctcc     1620

agcgaatcgg gagccaccaa cgacaaccac tacttcggct acagcacccc ctgggggtat     1680

tttgacttta acagattcca ctgtcacttc tcaccacgtg actggcagcg actcatcaac     1740

aacaactggg gatttagacc caagaaactc aatttcaagc tcttcaacat ccaagtcaag     1800

gaggtcacgc agaatgatgg aaccacgacc atcgccaata accttaccag cgcggtgcag     1860

gtcttcacag actctgagta ccagctgccc tacgtcctcg gttcggctca ccagggctgc     1920

cttccgccgt tcccagcaga cgtcttcatg attcctcagt acggctactt gactctgaac     1980

aatggcagcc aagcggtagg acgttcttca ttctactgtc tagagtattt tccctctcag     2040

atgctgagga cgggaaacaa cttcaccttc agctacactt ttgaagacgt gcctttccac     2100

agcagctacg cgcacagcca gagtctggat cggctgatga atcctctcat tgaccagtac     2160

ctgtattacc tgagcaaaac tcagggtaca agtggaacaa cgcagcaatc gagactgcag     2220

ttcagccaag ctgggcctag ctccatggct cagcaggcca aaaactggct accgggaccc     2280

agctaccgac agcagcgaat gtctaagacg gctaatgaca acaacaacag tgaatttgct     2340

tggactgcag ccaccaaata ttacctgaat ggaagaaatt ctctggtcaa tcccgggccc     2400

ccagtggcca gtcacaagga cgatgaggaa aagtatttcc ccatgcacgg aaatctcatc     2460

tttggaaaac aaggcacagg aactaccaat gtggacattg aatcagtgct tattacagac     2520

gaagaagaaa tcagaacaac taatcctgtg gctacagaac aatacggaca ggttgccacc     2580

aaccatcaga gtcagaacac cacagcttcc tatggaagtg tggacagcca gggaatctta     2640

cctggaatgg tgtggcagga ccgcgatgtc tatcttcaag gtcccatttg ggccaaaact     2700

cctcacacgg acggacactt tcatccttct ccgctcatgg gaggctttgg actgaaacac     2760

cctcctcccc agatcctgat caaaaacaca cctgtgccag cgaatcccgc gaccactttc     2820

actcctggaa agtttgcttc gttcattacc cagtattcca cctgacaggt cagcgtggaa     2880

atagagtggg agctgcagaa agaaaacagc aaacgctgga acccagaaat tcagtacacc     2940

tccaactaca acaagtcggt gaatgtggag tttaccgtgg acgcaaacgg tgtttattct     3000

gaaccccgcc ctattggcac tcgttacctt acccggaact tgtaatttcc tgttaatgaa     3060

taagccgatt tatgcgtttc agttgaactt tggtctctgc gaagggcgaa ttcgtttaaa     3120

cct                                                                   3123


<210>  130
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  130

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Asn Gln Gln His Arg Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


His Gln Leu Lys Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Gln Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Gly Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Glu Ser Gly Ala Thr Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Ala Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Gln Gly Thr Ser Gly Thr Thr Gln Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Ser Ser Met Ala Gln Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Ser Tyr Arg Gln Gln Arg Met Ser Lys Thr Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Phe Ala Trp Thr Ala Ala Thr Lys Tyr Tyr Leu Asn Gly 
            500                 505                 510         


Arg Asn Ser Leu Val Asn Pro Gly Pro Pro Val Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Met His Gly Asn Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Gly Thr Thr Asn Val Asp Ile Glu Ser Val Leu Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Gln Val Ala Thr Asn His Gln Ser Gln Asn Thr Thr Ala Ser Tyr 
            580                 585                 590         


Gly Ser Val Asp Ser Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Thr Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ala Thr Thr Phe Thr Pro Gly Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Glu Phe Thr Val Asp Ala Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  131
<211>  3123
<212>  DNA
<213>  Adeno-associated virus

<400>  131
gaattcgccc tttctacggc tgcgtcaact ggaccaatga aaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggaaagat gaccgccaag gtcgtggaat      120

ctgccaaagc cattctgggt ggaagcaagg ttcgtgtgga ccagaaatgc aagtcttcgg      180

cccagatcga cccgactccg gtgattgtca cctctaacac caacatgtgc gccgtgattg      240

acggaaactc gaccaccttc gagcaccagc agccgttgca agaccggatg ttcaaatttg      300

aacttacccg ccgtttggat catgactttg ggaaggtcac caagcaggaa gtcaaagact      360

ttttccggtg ggctcaagat cacgtgactg aggtggagca tgagttctac gtcaaaaagg      420

gtggagccaa gaaaaggccc gcccccgatg atgtatatat aaatgagccc aagcgggcgc      480

gcgagtcagt tgcgcagcca tcgacgtcag acgcggaagc ttcgataaac tacgcgggca      540

ggtaccaaaa caaatgttct cgtcacgtgg gcatgaatct gatgctgttt ccctgtcgac      600

aatgcgaaag aatgaatcag aattcaaata tctgcttcac acacgggcaa aaagactgtt      660

tggaatgctt tcccgtgtca gaatctcaac ccgtttctgt cgtcagaaaa acgtatcaga      720

aactttgtta cattcatcat atcatgggaa aagaaccaga cgcctgcact gcctgcgacc      780

tggtaaatgt ggacttggat gactgtattt ctgagcaata aatgacttaa atcaggtatg      840

gctgctgacg gttatcttcc agattggctc gaggacactc tctctgaagg aatcagacag      900

tggtggaagc tcaaacctgg cccaccaccg ccgaaaccta accaacaaca ccgggacgac      960

agtaggggtc ttgtgcttcc tgggtacaag tacctcggac ccttcaacgg actcgacaaa     1020

ggagagccgg tcaacgaggc agacgccgcg gccctcgagc acgacaaagc ctacgaccac     1080

cagctcaagc aaggggacaa cccgtacctc aaatacaacc acgcggacgc tgaatttcag     1140

gagcgtcttc aagaagatac gtctttcggg ggcaacctcg ggcgagcagt cttccaggcc     1200

aaaaagaggg tactcgagcc tcttggtctg gttgaggaag ctgttaagac ggctcctgga     1260

aaaaagagac ctatagagca gtctcctgca gaaccggact cttcctcggg catcggcgaa     1320

tcaggccagc agcccgctaa gaaaagactc aattttggtc agactggcga cacagagtca     1380

gtcccagacc ctcaaccaat cggagaaccc cccgcagccc cctctggtgt gggatctaat     1440

acaatggctt caggcggtgg ggcaccaatg gcagacgata acgaaggcgc cgacggagtg     1500

ggtaattcct cgggaaattg gcattgcgat tccacatgga tgggcgacag agttatcacc     1560

accagcacaa gaacctgggc cctccccacc tacaataatc acctctacaa gcaaatctcc     1620

agcgaatcgg gagccaccaa cgacaaccac tacttcggct acagcacccc ctgggggtat     1680

tttgacttta acagattcca ctgtcacttc tcaccacgtg actggcagcg actcatcaac     1740

aacaactggg gatttagacc caagaaactc aatttcaagc tcttcaacat ccaagtcaag     1800

gaggtcacgc agaatgatgg aaccacgacc atcgccaata accttaccag cacggtgcag     1860

gtcttcacag actctgagta ccagctgccc tacgtcctcg gttcggctca ccagggctgc     1920

cttccgccgt tcccagcaga cgtcttcatg attcctcagt acggctactt gactctgaac     1980

aatggcagcc aagcggtagg acgttcttca ttctactgtc tagagtattt tccctctcag     2040

atgctgagga cgggaaacaa cttcaccttc agctacactt ttgaagacgt gcctttccac     2100

agcagctacg cgcacagcca gagtctggat cggctgatga atcctctcat tgaccagtac     2160

ctgtattacc tgagcaaaac tcagggtaca agtggaacaa cgcagcaatc gagactgcag     2220

ttcagccaag ctgggcctag ctccatggct cagcaggcca aaaactggct accgggaccc     2280

agctaccgac agcagcgaat gtctaagacg gctaatgaca acaacaacag tgaatttgct     2340

tggactgcag ccaccaaata ttacctgaat ggaagaaatt ctctggtcaa tcccgggccc     2400

ccaatggcca gtcacaagga cgatgaggaa aagtatttcc ccatgcacgg aaatctcatc     2460

tttggaaaac aaggcacagg aactaccaat gtggacattg aatcagtgct tattacagac     2520

gaagaagaaa tcagaacaac taatcctgtg gctacagaac aatacggaca ggttgccacc     2580

aaccatcaga gtcaggacac cacagcttcc tatggaagtg tggacagcca gggaatctta     2640

cctggaatgg tgtggcagga ccgcgatgtc tatcttcaag gtcccatttg ggccaaaact     2700

cctcacacgg acggacactt tcatccttct ccgctcatgg gaggctttgg actgaaacac     2760

cctcctcccc agatcctgat caaaaacaca cctgtgccag cgaatcccgc gaccactttc     2820

actcctggaa agtttgcttc gttcattacc cagtattcca ccggacaggt cagcgtggaa     2880

atagagtggg agctgcagaa agaaaacagc aaacgctgga acccagaaat tcagtacacc     2940

tccaactaca acaagtcggt gaatgtggag tttaccgtgg acgcaaacgg tgtttattct     3000

gaaccccgcc ctattggcac tcgttacctt acccggaact tgtaatttcc tgttaatgaa     3060

taaaccgatt tatgcgtttc agttgaactt tggtctctgc gaagggcgaa ttcgcggccg     3120

cta                                                                   3123


<210>  132
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  132

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Asn Gln Gln His Arg Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


His Gln Leu Lys Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Gln Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Glu Ser Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asp Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Glu Ser Gly Ala Thr Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Gln Gly Thr Ser Gly Thr Thr Gln Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Ser Ser Met Ala Gln Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Ser Tyr Arg Gln Gln Arg Met Ser Lys Thr Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Phe Ala Trp Thr Ala Ala Thr Lys Tyr Tyr Leu Asn Gly 
            500                 505                 510         


Arg Asn Ser Leu Val Asn Pro Gly Pro Pro Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Met His Gly Asn Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Gly Thr Thr Asn Val Asp Ile Glu Ser Val Leu Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Gln Val Ala Thr Asn His Gln Ser Gln Asp Thr Thr Ala Ser Tyr 
            580                 585                 590         


Gly Ser Val Asp Ser Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Thr Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ala Thr Thr Phe Thr Pro Gly Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Glu Phe Thr Val Asp Ala Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  133
<211>  3113
<212>  DNA
<213>  Adeno-associated virus

<400>  133
gaattcgccc tttctacggc tgcgtcaact ggaccaatga aaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggaaagat gaccgccaag gtcgtggaat      120

ctgccaaagc cattctgggt ggaagcaagg ttcgtgtgga ccagaaatgc aagtcttcgg      180

cccagatcga cccgactccg gtgattgtca cctctaacac caacatgtgc gccgtgattg      240

acggaaactc gaccaccttc gagcaccagc agccgttgca agaccggatg ttcaaatttg      300

aacttacccg ccgtttggat catgactttg ggaaggtcac caagcaggaa gtcaaagact      360

ttttccggtg ggctcaagat cacgtgactg aggtggagca tgagttctac gtcaaaaagg      420

gtggagccaa gaaaaggccc gcccccgatg atgtatatat aaatgagccc aagcgggcgc      480

gcgagtcagt tgcgcagcca tcgacgtcag acgcggaagc ttcgataaac tacgcggaca      540

ggtaccaaaa caaatgttct cgtcacgtgg gcatgaatct gatgctgttt ccctgtcgac      600

aatgcgaaag aatgaatcag aattcaaata tctgcttcac acacgggcaa aaagactgtt      660

tggaatgctt tcccgtgtca gaatctcaac ccgttcctgt cgtcagaaaa acgtatcaga      720

aactttgtta cattcatcat atcatgggaa aagtaccaga cgcctgcact gcctgcgacc      780

tggtaaatgt ggacttggat gactgtattt ctgagcaata aatgacttaa atcaggtatg      840

gctgctgacg gttatcttcc agattggctc gaggacactc tctctgaagg aatcagacag      900

tggtggaagc tcaaacctgg cccaccaccg ccgaaaccta accaacaaca ccgggacgac      960

agtaggggtc ttgtgcttcc tgggtacaag tacctcggac ccttcaacgg actcgacaaa     1020

ggagagccgg tcaacgaggc agacgccgcg gccctcgagc acgacaaagc ctacgaccac     1080

cagctcaagc aaggggacaa cccgtacctc aaatacaacc acgcggacgc tgaatttcag     1140

gagcgtcttc aagaagatac gtctttcggg ggcaacctcg ggcgagcagt cttccaggcc     1200

aaaaagaggg tactcgagcc tcttggtctg gttgaggaag ctgttaagac ggctcctgga     1260

aaaaagagac ctatagagca gtctcctgca gaaccggact cttcctcggg catcggcaaa     1320

tcaggccagc agcccgctaa gaaaagactc aattttggtc agactggcga cacagagtca     1380

gtcccagacc ctcaaccaat cggagaaccc cccgcagccc cctctggtgt gggatctaat     1440

acaatggctt caggcggtgg ggcaccaatg gcagacaata acgaaggcgc cgacggagtg     1500

ggtaattcct cgggaaattg gcattgcgat tccacatgga tgggcgacag agttatcacc     1560

accagcacaa gaacctgggc cctccccacc tacaataatc acctctacaa gcaaatctcc     1620

agcgaatcgg gagccaccaa cgacaaccac tacttcggct acagcacccc ctgggggtat     1680

tttgacttta acagattcca ctgtcacttc tcaccacgtg actggcagcg actcatcaat     1740

aacaactggg gatttagacc caagaaactc aatttcaagc tcttcaacat ccaagtcaag     1800

gaggtcacgc agaatgatgg aaccacgacc atcgccaata accttaccag cacggtgcag     1860

gtcttcacag actctgagta ccagctgccc tacgtcctcg gttcggctca ccagggctgc     1920

cttccgccgt tcccagcaga cgtcttcatg attcctcagt acggctactt gactctgaac     1980

aatggcagcc aagcggtagg acgttcttca ttctactgtc tagagtattt tccctctcag     2040

atgctgagga cgggaaacaa cttcaccttc agctacactt ttgaagacgt gcctttccac     2100

agcagctacg cgcacagcca gagtctggat cggctgatga atcctctcat tgaccagtac     2160

ctgtattacc tgagcaaaac tcagggtaca agtggaacaa cgcagcaatc gagactgcag     2220

ttcaaccaag ctgggcctag ctccatggct cagcaggcca aaaactggct accgggaccc     2280

agctaccgac agcagcgaat gtctaagacg gctaatgaca acaacaacag tgaatttgct     2340

tggactgcag ccaccaaata ttacccgaat ggaagaaatt ctctggtcaa tcccgggccc     2400

ccaatggcca gtcacaagga cgatgaggaa aagtatttcc ccatgcacgg aaatctcatc     2460

tttggaaaac aaggcacagg aactaccaat gtggacattg aatcagtgct tattacagac     2520

gaagaagaaa tcagaacgac taatcctgtg gctacagaac aatacggaca ggttgccacc     2580

aaccgtcaga gtcagaacac cacagcttcc tatggaagtg tggacagcca gggaatctta     2640

cctggaatgg tgtggcagga ccgcgatgtc tatcttcaag gtcccatttg ggccaaaact     2700

cctcacacgg acggacactt tcatccttct ccgctcatgg gaggctttgg actgaaacac     2760

cctcctcccc agatcctgat caaaaacaca cctgtgccag cgaatcccgc gaccactttc     2820

actcctggaa agtttgcttc gttcattacc cagtattcca ccggacaggt cagcgtggaa     2880

atagagtggg agctgcagaa agaaaacagc aaacgctgga acccggaaat tcagtacacc     2940

tccaactaca acaagtcggt gaatgtggag tttaccgtgg acgcaaacgg tgtttattct     3000

gaaccccgcc ctattggcac tcgttacctt acccggaact tgtaatttcc tgttaatgaa     3060

taaaccgatt tatgcgtttc agttgaactt tggtctctgc gaagggcgaa ttc            3113


<210>  134
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  134

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Asn Gln Gln His Arg Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


His Gln Leu Lys Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Gln Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Glu Ser Gly Ala Thr Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Gln Gly Thr Ser Gly Thr Thr Gln Gln Ser Arg Leu Gln Phe Asn Gln 
    450                 455                 460                 


Ala Gly Pro Ser Ser Met Ala Gln Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Ser Tyr Arg Gln Gln Arg Met Ser Lys Thr Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Phe Ala Trp Thr Ala Ala Thr Lys Tyr Tyr Pro Asn Gly 
            500                 505                 510         


Arg Asn Ser Leu Val Asn Pro Gly Pro Pro Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Met His Gly Asn Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Gly Thr Thr Asn Val Asp Ile Glu Ser Val Leu Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Gln Val Ala Thr Asn Arg Gln Ser Gln Asn Thr Thr Ala Ser Tyr 
            580                 585                 590         


Gly Ser Val Asp Ser Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Thr Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ala Thr Thr Phe Thr Pro Gly Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Glu Phe Thr Val Asp Ala Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  135
<211>  3122
<212>  DNA
<213>  Adeno-associated virus

<400>  135
agcggccgcg aattcgccct ttctacggct gcgtcaactg gaccaatgaa aactttccct       60

tcaacgattg cgtcgacaag atggtgatct ggtgggagga gggaaagatg accgccaagg      120

tcgtggaatc tgccaaagcc attctgggtg gaagcaaggt tcgtgtggac cagaaatgca      180

ggtcttcggc ccagatcgac ccgactccgg tgattgtcac ctctaacacc aacatgtgcg      240

ccgtgattga cggaaactcg accaccttcg agcaccagca gccgttgcaa gaccggatgt      300

tcaaatttga acttacccgc cgtttggatc atgactttgg gaaggtcacc aagcaggaag      360

tcaaagactt tttccggtgg gctcaagatc acgtgactga ggtggagcat gagttctacg      420

tcaaaaaggg tggagccaag aaaaggcccg cccccgatga tgtatatata aatgagccca      480

agcgggcgcg cgagtcagtt gcgcagccat cgacgtcaga cgcggaagct tcgataaact      540

acgcggacag gtaccaaaac aaatgttctc gtcacgtggg catgaatctg atgctgtttc      600

cctgtcgaca atgcgaaaga atgaatcaga attcaaatat ctgcttcaca cacgggcaaa      660

aagactgttt ggaatgcttt cccgtgtcag aatctcaacc cgtttctgtc gtcagaaaaa      720

cgtatcagaa actttgttac attcatcata tcatgggaaa agtaccagac gcctgcactg      780

cctgcgacct ggtaaatgtg gacttggatg actgtatttc tgagcaataa atgacttaaa      840

tcaggtatgg ctgctgacgg ttatcttcca gattggctcg aggacactct ctctgaagga      900

atcagacagt ggtggaagct caaacctggc ccaccaccgc cgaaacctaa ccaacaacac      960

cgggacgaca gtaggggtct tgtgcttcct gggtacaagt acctcggacc cttcaacgga     1020

ctcgacaaag gagagccggt caacgaggca gacgccgcgg ccctcgagca cgacaaagcc     1080

tacgaccacc agctcaagca aggggacaac ccgtacctca aatacaacca cgcggacgct     1140

gaatttcagg agcgtcttca agaagatacg tctttcgggg gcaacctcgg gcgagcagtc     1200

ttccaggcca aaaagagggt actcgagcct cttggtctgg ttgaggaagc tgttaagacg     1260

gctcctggaa aaaagagacc tatagagcag tctcctgcag aaccggactc ttcctcgggc     1320

atcggcaaat caggccagca gcccgctaag aaaagactca attttggtca gactggcgac     1380

acagagtcag tcccagaccc tcaaccaatc ggagaacccc ccgcagcccc ctctggtgtg     1440

ggatctaata caatggcttc aggcggtggg gcaccaatgg cagacaataa cgaaggcgcc     1500

gacggagtgg gtaattcctc gggaaattgg cattgcgatt ccacatggat gggcgacaga     1560

gttatcacca ccagcacaag aacctgggcc ctccccacct acaataatcg cctctacaag     1620

caaatctcca gcgaatcggg agccaccaac gacaaccact acttcggcta cagcaccccc     1680

tgggggtatt ttgactttaa cagattccac tgtcacttct caccacgtga ctggcagcga     1740

ctcatcaaca acaactgggg atttagaccc aagaaactca atttcaagct cttcaacatc     1800

caagtcaagg aggtcacgca gaatgatgga accacgacca tcgccaataa ccttaccagc     1860

acggtgcagg tcttcacaga ctctgagtac cagctgccct acgtcctcgg ttcggctcac     1920

cagggctgcc ttccgccgtt cccagcagac gtcttcatga ttcctcagta cggctacttg     1980

actctgaaca atggcagcca agcggtagga cgttcttcat tctactgtct agagtatttt     2040

ccctctcaga tgctgaggac gggaaacaac ttcaccttca gctacacttt tgaagacgtg     2100

cctttccaca gcagctacgc gcacagccag agtctggatc ggctgatgaa tcctctcatt     2160

gaccagtacc tgtattacct gagcaaaact cagggtacaa gtggaacaac gcagcaatcg     2220

agactgcagt tcagccaagc tgggcctagc tccatggctc agcaggccaa aaactggcta     2280

ccgggaccca gctaccgaca gcagcgaatg tctaagacgg ctaatgacaa caacaacagt     2340

gaatttgctt ggactgcagc caccaaatat tacctgaatg gaagaaattc tctggtcaat     2400

cccgggcccc caatggccag tcacaaggac gatgaggaaa agtatttccc catgcacgga     2460

aatctcatct ttggaaaaca aggcacagga actaccaatg tggacattga atcagtgctt     2520

attacagacg aagaagaaat cagaacaact aatcctgtgg ctacagaaca atacggacag     2580

gttgccacca accatcagag tcagaacacc acagcttcct atggaagtgt ggacagccag     2640

ggaatcttac ctggaatggt gtggcaggac cgcgatgtct atcttcaagg tcccatttgg     2700

gccaaaactc ctcacacgga cggacacttt catccttctc cgctcatggg aggctttgga     2760

ctgaaacacc ctcctcccca gatcctgatc aaaaacacac ctgtgccagc gaatcccgcg     2820

accactttca ctcctggaaa gtttgcttcg ttcattaccc agtattccac cggacaggtc     2880

agcgtggaaa tagagtggga gctgcagaaa gaaaacagca aacgctggaa cccagaaatt     2940

cagtacacct ccaactacaa caagtcggtg aatgtggagt ttaccgtgga cgcaaacggt     3000

gtttattctg aaccccgccc tattggcact cgttacctta cccggaactt gtaatttcct     3060

gttaatgaat aaaccgattt atgcgtttca gttgaacttt ggtctctgcg aagggcgaat     3120

tc                                                                    3122


<210>  136
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  136

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Asn Gln Gln His Arg Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


His Gln Leu Lys Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Gln Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn Arg Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Glu Ser Gly Ala Thr Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Gln Gly Thr Ser Gly Thr Thr Gln Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Ser Ser Met Ala Gln Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Ser Tyr Arg Gln Gln Arg Met Ser Lys Thr Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Phe Ala Trp Thr Ala Ala Thr Lys Tyr Tyr Leu Asn Gly 
            500                 505                 510         


Arg Asn Ser Leu Val Asn Pro Gly Pro Pro Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Met His Gly Asn Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Gly Thr Thr Asn Val Asp Ile Glu Ser Val Leu Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Gln Val Ala Thr Asn His Gln Ser Gln Asn Thr Thr Ala Ser Tyr 
            580                 585                 590         


Gly Ser Val Asp Ser Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Thr Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ala Thr Thr Phe Thr Pro Gly Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Glu Phe Thr Val Asp Ala Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  137
<211>  3121
<212>  DNA
<213>  Adeno-associated virus

<400>  137
gaattcgccc ttcgcagaga ccaaagttca actgaaacga atcaaccggt ttattgatta       60

acaagcaatt acagattacg ggtgaggtaa cgggtgccga tggggcgagg ctcagaataa      120

gtgccatctg tgttaacagc aaagtccaca tttgtagatt tgtagtagtt ggaagtgtat      180

tgaatctctg ggttccagcg tttgctgttt tctttctgca gctcccattc aatttccacg      240

ctgacctgtc cggtgctgta ctgcgtgatg aacgacgcca gcttagcttg actgaaggta      300

gttggaggat ccgcgggaac aggtgtattc ttaatcagga tctgaggagg cgggtgtttc      360

agtccaaagc cccccatcag cggcgaggga tgaaagtttc cgtccgtgtg aggaatcttg      420

gcccagatag gaccctgcag gtacacgtcc cggttctgcc agaccatgcc aggtaaggct      480

ccttgactgt tgacggcccc tacaatagga gcggcgtttt gctgttgcag gttatcggcc      540

accacgccgt actgttctgt ggccactggg ttggtggttt taatttcttc ctcactggtt      600

agcataacgc tgctatagtc cacgttgcct tttccagctc cctgtttccc aaacattaag      660

actccgctgg acggaaaaaa tcgctcttcg tcgtccttgt gggttgccat agcgacaccg      720

ggatttacca gagagtctct gccattcaga tgatacttgg tggcaccggt ccaggcaaag      780

ttgctgttgt tattttgcga cagtgtcgtg gagacgcgtt gctgccggta gcagggcccg      840

ggtagccagt ttttggcctg agccgacatg ttattaggcc cggcctgaga aaatagcaac      900

tgctgagttc ctgcggtacc tcccgtggac tgagtccgag acaggtagta caggtactgg      960

tcgatgaggg ggttcatcag ccggtccagg ctttggctgt gcgcgtagct gctgtgaaaa     1020

ggcacgtcct caaactggta gctgaactca aagttgttgc ccgttctcag catttgagaa     1080

ggaaagtact ccaggcagta gaaggaggaa cggcccacgg cctgactgcc attgttcaga     1140

gtcaggtacc cgtactgagg aatcatgaag acgtccgccg ggaacggagg caggcagccc     1200

tggcgcgcag agccgaggac gtacgggagc tggtattccg agtccgtaaa gacctgaatc     1260

gtgctggtaa ggttattggc gatggtcttg gtgccttcat tctgcgtgac ctccttgacc     1320

tggatgttga agagcttgaa gttgagtctc ttgggccgga atccccagtt gttgttgatg     1380

agtcgctgcc agtcacgtgg tgagaagtgg cagtggaatc tgttaaagtc aaaatacccc     1440

cagggggtgc tgtagccgaa gtaggtgttg tcgttggtgc ttcctcccga agtcccgttg     1500

gagatttgct tgtagaggtg gttgttgtag gtggggaggg cccaggttcg ggtgctggtg     1560

gtgatgactc tgtcgcccag ccatgtggaa tcgcaatgcc aatttcctga ggaactaccc     1620

actccgtcgg cgccttcgtt attgtctgcc attggagcgc caccgcctgc agccattgta     1680

ccagatccca gaccagaggg gcctgcgggg ggttctccga ttggttgagg gtcgggcact     1740

gactctgagt cgccagtctg cccaaagttg agtctctttt tcgcgggctg ctggcctttc     1800

ttgccgatgc ccgtagtgga gtctggagaa cgctggggtg atggctctac cggtctcttc     1860

tttccaggag ccgtcttagc gccttcctca accagaccga gaggttcgag aacccgcttc     1920

ttggcctgga agactgctcg tccgaggttg cccccaaaag acgtatcttc ttgcagacgc     1980

tcctgaaact cggcgtcggc gtggttatac cgcaggtacg gattgtcacc cgctttgagc     2040

tgctggtcgt aggccttgtc gtgctcgagg gccgctgcgt ccgccgcgtt gacgggctcc     2100

cccttgtcga gtccgttgaa gggtccgagg tacttgtagc caggaagcac cagaccccgg     2160

ccgtcgtcct gcttttgctg gttggctttg ggcttcgggg ctccaggttt cagcgcccac     2220

cactcgcgaa tgccctcaga gaggttgtcc tcgagccaat ctggaagata accatcggca     2280

gccatacctg atctaaatca tttattgttc aaagatgcag tcatccaaat ccacattgac     2340

cagatcgcag gcagtgcaag cgtctggcac ctttcccatg atatgatgaa tgtagcacag     2400

tttctgatac gcctttttga cgacagaaac gggttgagat tctgacacgg gaaagcactc     2460

taaacagtct ttctgtccgt gagtgaagca gatatttgaa ttctgattca ttctctcgca     2520

ttgtctgcag ggaaacagca tcagattcat gcccacgtga cgagaacatt tgttttggta     2580

cctgtccgcg tagttgatcg aagcttccgc gtctgacgtc gatggctgcg caactgactc     2640

gcgcacccgt ttgggctcac ttatatctgc gtcactgggg gcgggtcttt tcttggctcc     2700

accctttttg acgtagaatt catgctccac ctcaaccacg tgatcctttg cccaccggaa     2760

aaagtctttg acttcctgct tggtgacctt cccaaagtca tgatccagac ggcgggtgag     2820

ttcaaatttg aacatccggt cttgcaacgg ctgctggtgt tcgaaggtcg ttgagttccc     2880

gtcaatcacg gcgcacatgt tggtgttgga ggtgacgatc acgggagtcg ggtctatctg     2940

ggccgaggac ttgcatttct ggtccacgcg caccttgctt cctccgagaa tggctttggc     3000

cgactccacg accttggcgg tcatcttccc ctcctcccac cagatcacca tcttgtcgac     3060

acagtcgttg aagggaaagt tctcattggt ccagttgacg cagccgtaga agggcgaatt     3120

c                                                                     3121


<210>  138
<211>  733
<212>  PRT
<213>  Adeno-associated virus

<400>  138

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Leu 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe His Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Leu Glu Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly Lys 
145                 150                 155                 160 


Lys Gly Lys Gln Pro Ala Lys Lys Arg Leu Asn Phe Glu Glu Asp Thr 
                165                 170                 175     


Gly Ala Gly Asp Gly Pro Pro Glu Gly Ser Asp Thr Ser Ala Met Ser 
            180                 185                 190         


Ser Asp Ile Glu Met Arg Ala Ala Pro Gly Gly Asn Ala Val Asp Ala 
        195                 200                 205             


Gly Gln Gly Ser Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys 
    210                 215                 220                 


Asp Ser Thr Trp Ser Glu Gly Lys Val Thr Thr Thr Ser Thr Arg Thr 
225                 230                 235                 240 


Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Leu Arg Leu Gly Thr 
                245                 250                 255     


Thr Ser Asn Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Asn Trp Gly Leu Arg Pro Lys Ala Met Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu 
305                 310                 315                 320 


Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp 
                325                 330                 335     


Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser 
            340                 345                 350         


Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Cys Gly Ile Val Thr Gly Glu Asn Gln Asn Gln Thr Asp Arg Asn Ala 
    370                 375                 380                 


Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Met Ala Tyr Asn Phe Glu Lys Val Pro Phe His Ser Met 
                405                 410                 415     


Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Leu Asp 
            420                 425                 430         


Gln Tyr Leu Trp His Leu Gln Ser Thr Thr Ser Gly Glu Thr Leu Asn 
        435                 440                 445             


Gln Gly Asn Ala Ala Thr Thr Phe Gly Lys Ile Arg Ser Gly Asp Phe 
    450                 455                 460                 


Ala Phe Tyr Arg Lys Asn Trp Leu Pro Gly Pro Cys Val Lys Gln Gln 
465                 470                 475                 480 


Arg Phe Ser Lys Thr Ala Ser Gln Asn Tyr Lys Ile Pro Ala Ser Gly 
                485                 490                 495     


Gly Asn Ala Leu Leu Lys Tyr Asp Thr His Tyr Thr Leu Asn Asn Arg 
            500                 505                 510         


Trp Ser Asn Ile Ala Pro Gly Pro Pro Met Ala Thr Ala Gly Pro Ser 
        515                 520                 525             


Asp Gly Asp Phe Ser Asn Ala Gln Leu Ile Phe Pro Gly Pro Ser Val 
    530                 535                 540                 


Thr Gly Asn Thr Thr Thr Ser Ala Asn Asn Leu Leu Phe Thr Ser Glu 
545                 550                 555                 560 


Gly Glu Ile Ala Ala Thr Asn Pro Arg Asp Thr Asp Met Phe Gly Gln 
                565                 570                 575     


Ile Ala Asp Asn Asn Gln Asn Ala Thr Thr Ala Pro Ile Thr Gly Asn 
            580                 585                 590         


Val Thr Ala Met Gly Val Leu Pro Gly Met Val Trp Gln Asn Arg Asp 
        595                 600                 605             


Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His Ala Asp Gly 
    610                 615                 620                 


His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys His Pro 
625                 630                 635                 640 


Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Ala 
                645                 650                 655     


Thr Thr Phe Thr Ala Ala Arg Val Asp Ser Phe Ile Thr Gln Tyr Ser 
            660                 665                 670         


Thr Gly Gln Val Ala Val Gln Ile Glu Trp Glu Ile Glu Lys Glu Arg 
        675                 680                 685             


Ser Lys Arg Arg Asn Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly Asn 
    690                 695                 700                 


Gln Ser Ser Met Leu Trp Ala Pro Asp Thr Thr Gly Lys Tyr Thr Glu 
705                 710                 715                 720 


Pro Arg Val Ile Gly Ser Arg Tyr Leu Thr Asn His Leu 
                725                 730             


<210>  139
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  139

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Asn Gln Gln His Arg Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


His Gln Leu Lys Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Gln Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Glu Ser Gly Ala Thr Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Gln Gly Thr Ser Gly Thr Thr Gln Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Ser Ser Met Ala Gln Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Ser Tyr Arg Gln Gln Arg Met Ser Lys Thr Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Phe Ala Trp Thr Ala Ala Thr Lys Tyr Tyr Leu Asn Gly 
            500                 505                 510         


Arg Asn Ser Leu Val Asn Pro Gly Pro Pro Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Met His Gly Asn Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Gly Thr Thr Asn Val Asp Ile Glu Ser Val Leu Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Gln Val Ala Thr Asn His Gln Ser Gln Asn Thr Thr Ala Ser Tyr 
            580                 585                 590         


Gly Ser Val Asp Ser Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ala Thr Thr Phe Thr Pro Gly Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Glu Phe Thr Val Asp Ala Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  140
<211>  3127
<212>  DNA
<213>  Adeno-associated virus

<400>  140
gcggccgcga attcgccctt cgcagagacc aaagttcaac tgaaacgaat caaccggttt       60

attgattaac atgcaattac agattacggg tgaggtaacg agtgccaata gggcgaggct      120

cagagtaaac accctggctg tcaacggcaa agtccacacc agtctgcttt tcaaagttgg      180

aggtgtactg aatctccggg tcccagcgct tgctgttttc cttctgcagc tcccactcga      240

tttccacgct gacttgtccg gtgctgtact gtgtgatgaa cgaagcaaac ttggcaggag      300

taaacacctc cggaggatta gcgggaacgg gagtgttctt gatcaggatc tgaggaggcg      360

gatgtttaag tccaaagccg cccatcaaag gagacgggtg aaagttgcca tccgtgtgag      420

gaatcttggc ccagatggga ccctgcaggt acacgtcccg gttctgccag accatgccag      480

gtaaggctcc ctggttgttg acaacttgtg tctgggctgc agtattagcc gcttgtaagt      540

tgctgctgac tatcccgtat tcttccgtgg ctacaggatt agtaggacga atttcttctt      600

catttgtcat taacacattt tccaatgtag ttttgttagt tgctccagtt tttccaaaaa      660

tcaggactcc gctggatggg aaaaagcggt cctcgtcgtc cttgtgagtt gccatggcga      720

cgccgggatt aaccaacgag tttctgccgt tcaggtgata tttggtggca ccagtccaag      780

caaagttgct gttgttgttt tgatccagcg ttttggagac cctttgttgc cggaagcagg      840

gtccaggtaa ccaattcttg gcttgttcgg ccatagttga aggcccgccc tggtaaaact      900

gcagttcccg attgccagct gtgcctcctg ggtcactctg tgttctggcc aggtagtaca      960

agtactggtc gatgagggga ttcatcagcc ggtccaggct ctggctgtgt gcgtagctgc     1020

tgtggaaagg cacgtcctcg aagctgtagc tgaactcaaa gttgttgccc gttctcagca     1080

tctgagaggg gaagtactcc aggcagtaga aggaggaacg tcccacagac tgactgccat     1140

tgttgagagt caggtagccg tactgaggaa tcatgaagac gtccgccggg aacggaggca     1200

ggcagccctg gtgcgcagag ccgaggacgt acggcagctg gtattccgag tccgagaata     1260

cctgaatcgt gctggtaagg ttattagcga tggtcgtaac gccgtcattc gtcgtgacct     1320

ccttgacctg gatgttgaag agcttgaacc gcagcttctt gggccggaat ccccagttgt     1380

tgttgatgag tcgctgccag tcacgtggtg agaagtggca gtggaatctg ttaaagtcaa     1440

aataccccca gggggtgctg tagccgaagt aggtgttgtc gttggtacta cctgcagttt     1500

cactggagat ttgctcgtag aggtggttgt tgtaggtggg cagggcccag gttcgggtgc     1560

tggtggtaat gactctgtcg cccagccatg tggaatcgca atgccaattt cctgaggcat     1620

tacccactcc gtcggcacct tcgttattgt ctgccattgg tgcgccaccg cctgcagcca     1680

ctgtaccaga tcccacacta gagggcgctg ctggaggttc tccgagaggt tgagggtcgg     1740

ggactgactc tgagtcgcca gtctgaccga aattgagtct ctttctggcg ggctgctggc     1800

ccttcttgcc gatgcccgtg gaggagtcgg gggaacgctg aggtgacggc tctaccggtc     1860

tcttctttgc aggagccgtc ttagcgcctt cctcaaccag accgagaggt tcgagaaccc     1920

gcttcttggc ctggaagact gctcgcccga ggttgccccc aaatgacgta tcttcttgca     1980

gacgctcctg aaactcggcg tcggcgtggt tataccgcag gtacgggttg tcacccgcat     2040

tgagctgctg gtcgtaggcc ttgtcgtgct cgagggccgc tgcgtccgcc gcgttgacgg     2100

gctccccctt gtcgagtccg ttgaagggtc cgaggtactt gtagccagga agcaccagac     2160

cccggccgtt gtcctgcttt tgctggttgg ctttgggttt cggggctcca ggtttcaggt     2220

cccaccactc gcgaatgccc tcagagaggt tgtcctcgag ccaatctgga agataaccat     2280

cggcagccat acctgattta aatcatttat tgttcaaaga tgcagtcatc caaatccaca     2340

ttgaccagat cgcaggcagt gcaagcgtct ggcacctttc ccatgatatg atgaatgtag     2400

cacagtttct gatacgcctt tttgacgaca gaaacgggtt tagattctga cacgggaaag     2460

cactctaaac agtctttctg tccgtgagtg aagcagatat ttgaattctg attcattctc     2520

tcgcattgtc tgcagggaaa cagcatcaga ttcatgccca cgtgacgaga acatttgttt     2580

tggtacctgt ctgcgtagtt gatcgaagct tccgcgtctg acgtcgatgg ctgcgcaact     2640

gactcgcgca cccgtttggg ctcacttata tctgcgtcac tgggggcggg tcttttcttg     2700

gctccaccct ttttgacgta gaattcatgc tccacctcaa ccacgtaatc ctttgcccac     2760

cggaaaaagt ctttgacttc ctgcttggtg accttcccaa agtcatgatc cagacggcgg     2820

gtgagttcaa atttgaacat ccggtcttgc aacggctgct ggtgttcgaa ggtcgttgag     2880

ttcccgtcga tcacggcgca catgttggtg ttggagatga cgatcgcggg agtcgggtct     2940

atctgggccg aggacttgca tttctggtcc acgcgcacct tgcttcctcc gagaatggct     3000

ttggccgact ccacgacctt ggcggtcatc ttcccctcct cccaccagat caccatcttg     3060

tcgacacagt cgttgaaggg aaagttctca ttggtccagt tgacgcagcc gtagaaaggg     3120

cgaattc                                                               3127


<210>  141
<211>  728
<212>  PRT
<213>  Adeno-associated virus

<400>  141

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Arg Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Val Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Ser Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Val His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Cys Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210>  142
<211>  3106
<212>  DNA
<213>  Adeno-associated virus

<400>  142
gcggccgcga attcgccctt cgcagagacc aaagttcaac tgaaacgaat caaccggttt       60

attgattaac aagtaattac aggttacggg tgaggtaacg ggtgccaatg gggcgaggct      120

cagtataaac cccttcgttg ttgacagcaa attccacatt attagacttg gcataatttg      180

aggtgtactg aatctctgga ttccagcgtt tgctgttttc tttctgcagt tcccactcga      240

tctccacgct gacctggccg gtgctgtact gcgtgataaa tgaggcaaac ttggcaggag      300

taaacacctc tggaggatta gcaggtaccg gggtgttttt gatgagaatt tgaggaggcg      360

ggtgtttgag tccaaatccg cccatcaggg gagacgggtg aaagttgccg tccgtgtgag      420

gaattttggc ccagatggga ccctgcaggc acacgtcccg gttctgccag accatgccgg      480

gcagagcccc ctggctgttg acagtctgtg tctggggtcc ggccgtagac gattgcaggt      540

tgctggagac cacaccgtat tcttctgtag ccacgggatt ggtggttttg atctcctcct      600

cgctggtcat tagcacgttt tccagcgttg tcttgttggc agcccccgtt ttgccaaaaa      660

ccagcactcc gttgatggga aagaactggt cctcgtcgtc cttgttggtg gccatggcta      720

cgcccgggtt ggttaatgaa tttctaccat tcagatggta tttagtggcc ccggtccagg      780

caaagttact gttgttgttg ctgtctatgt tttttgacag tctctgctgc cgataacagg      840

gtccgggcag ccagttcttt gattgctcgg ccatggtgtt gggcccagcc tgatggaact      900

gcagctccct tgtggacccc gtagtgctct gggtccgggc caggtagtac aggtactggt      960

cgatgagggg attcatcagc cggtctaggc tctggctgtg cacatagctg ctgtggaaag     1020

gcacttcctc aaaggtgtag ctgaattcaa agttattgcc cgttctcagc atctgagaag     1080

gaaagtactc caggcagtag aaggaggaac gtcccacaga ctgactgccg ttgtttagag     1140

tcagatatcc gtactgagga atcatgaaca cgtccgcagg gaacggaggg aggcagccct     1200

ggtgcgcaga gccgaggacg tacggcagtt ggtactccga gtccgagaag acctgaatcg     1260

tgctggtaag gttattagcg atggtcgtaa cgccgtcgtt cgtcgtgacc tccttgacct     1320

ggatgttgaa caacttgaac cgcagctttc tgggccggaa tccccagttg ttgttgatga     1380

gtcgctgcca gtcacgtggt gagaagtggc agtggaatct gttgaagtca aaatagcccc     1440

agggggtgct gtagctgaag aagtggttgt cgttggtagc cccgctctga cttgatatct     1500

gcttgtagag gtggttgttg taggtgggca gggcccaggt gcgggtgctg gtggtgatga     1560

ctctgtcgcc cagccatgtg gaatcgcaat gccaatttcc ggaggcatta cccactccgt     1620

cggcgccttc gttattgtct gccattggtg cgccaccgcc tgcagccatt gtaccagatc     1680

ccagacctga gggcgcggcg ggaggttctc cgagaggttg ggggtcgggc actgactctg     1740

agtcgccagt ctgcccaaag ttgagcttct ttttagcggg ctgctggcct ttcttgccga     1800

tgcccgtgga ggagtcgggg gattctatgg gtctcttctt tccaggagcc gtcttagcga     1860

cttcctcaac cagaccgaga ggttcgagaa cccgcttctt ggcctggaag actgctcgcc     1920

cgaggttgcc cccaaaagac gtatcttctt gaagacgctc ctgaaactcg gcgtcggcgt     1980

ggttgtactt gaggtacggg ttgtccccct gctcgagctg cttgtcgtag gccttgtcgt     2040

gctcgagggc cgcggcgtct gcctcgttga ccggctctcc cttgtcgagt ccgttgaagg     2100

gtctgaggta cttgtagcca ggaagcacca gaccccggcc gtcgtcctgc ttttgctggt     2160

tggctttggg tttcggggct ccaggtttca agtcccacca ctcgcgaatg ccctcagaga     2220

ggttgtcctc gagccaatct ggaagataac catcggcagc catacctggt ttaagtcatt     2280

tattgctcag aaacacagtc atccaggtcc acgttgacca gatcgcaggc cgagcaagca     2340

atctcgggag cccgccccag cagatgatga atggcacaga gtttccgata cgtcctcttt     2400

ctgacgaccg gttgagattc tgacacgccg gggaaacatt ctgaacagtc tctggtcccg     2460

tgcgtgaagc aaatgttgaa attctgattc actctctcgc atgtcttgca gggaaacagc     2520

atctgaagca tgcccgcgtg acgagaacat ttgttttggt acctgtcggc aaagtccacc     2580

ggagctcctt ccgcgtctga cgtcgatgga ttcgcgactg aggggcaggc ccgcttgggc     2640

tcgcttttat ccgcgtcatc gggggcgggt ctcttgttgg ccccaccctt tctgacgtag     2700

aacccatgcg ccacctcggt cacgtgatcc tgcgcccagc ggaagaacct tttgacttcc     2760

tgctttgtca ccttgccaaa gttatgctcc agacggcggg tgggttcaaa tttgaacatc     2820

cggtcctgca acggctgctg gtgctcgaag gtggcgctgt tcccgtcaat cacggcgcac     2880

atgttggtgt tggaggtgac ggtcacgggg gtggggtcga tctgggcgga cgacttgcac     2940

ttttggtcca cgcgcacctt gctgccgccg agaatggcct tggcggactc cacgaccttg     3000

gccgtcatct tgccctcctc ccaccagatc accatcttgt cggcgcaatc gttgaaggga     3060

aagttctcat tggtccagtt gacgcagccg tagaaagggc gaattc                    3106


<210>  143
<211>  728
<212>  PRT
<213>  Adeno-associated virus

<400>  143

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Ser Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Cys Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Val 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Leu 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Arg Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Glu Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210>  144
<211>  3102
<212>  DNA
<213>  Adeno-associated virus

<400>  144
gcggccgcga attcgccctt cgcagagacc aaagttcaac tgaaacgaat caaccggttt       60

attgattaac aagtaattac aggttacggg tgaggtaacg ggtgccaatg gggcgaggct      120

cagtataaac cccttcgttg ttgacagcaa attccacatt attagacttg gcataatttg      180

aggtgtactg aatctctgga ttccagcgtt tgctgttttc tttctgcagt tcccactcga      240

tctccacgct gacctggccg gtgctgtact gcgtgataaa tgaggcaaac ttggcaggag      300

taaacacctc tggaggatta gcaggtaccg gggtgttttt gatgagaatt tgaggaggcg      360

ggtgtttgag tccaaatccg cccatcaggg gagacgggtg aaagttgccg tccgtgtgag      420

gaatttcggc ccagatggga ccctgcaggt acacgtcccg gttctgccag accatgccgg      480

gcagagcccc ctggctgttg acagtctgtg tccggggtcc ggccgtagac gattgcaggt      540

tgctggagac cacaccgtat tcttctgtag ccacgggatt ggtggttttg atctcctcct      600

cgctggtcat tagcacgttt tccagcgttg tcttgttggc agcccccgtt ttgccaaaaa      660

ccagcactcc gttgatggga aggaactggt cctcgtcgtc cttgttggtg gccatggcta      720

cgcccgggtt ggttaatgaa tttctaccat tcagatggta tttagtggcc ccggtccagg      780

caaagttact gttgttgttg ctgtctatgt tttttgacag tctctgctgc cgataacagg      840

gtccgggcag ccagttcttt gattgctcgg ccacggtgtt gggcccagcc tgatggaact      900

gcagctccct tgtggacccc gtagtgctct gggtccgggc caggtagtac aggtactggt      960

cgatgagggg attcatcagc cggtccaggc tctggctgtg cgcatagctg ctgtggaaag     1020

gcacttcctc aaaggtgtag ctgaattcaa agttattgcc cgttctcagc atctgagaag     1080

gaaagtactc caggcagcag aaggaggaac gtcccacaga ctgactgccg ttgtttagag     1140

tcagatatcc gtactgagga atcatgaaca cgtccgcagg gaacggaggg aggcagccct     1200

ggtgcgcaga gccgaggacg tacggcagtt ggtactccga gtccgagaag acctgaatcg     1260

tgctggtaag gttattagcg atggtcgtaa cgccgtcgtt cgtcgtgacc tccttgacct     1320

ggatgttgaa caacttgaac cgcagctttc tgggccggaa tccccagttg ttgttgatga     1380

gtcgctgcca gtcacgtggt gagaagtggc agtggaatct gttgaagtca aaatagcccc     1440

agggggtgct gtagccgaag aagtggttgt cgttggtagc cccgctctga cttgatatct     1500

gcttgtagag gtggttgttg taggtgggca gggcccaggt gcgggtgctg gtggtgatga     1560

ctctgtcgcc cagccatgtg gaatcgcaat gccaatttcc ggaggcatta cccactccgt     1620

cggcgccttc gttattgtct gccattggtg cgccaccgcc tgcagccatt gtaccagatc     1680

ccagacctga gggcgcggcg ggaggttctc cgagaggttg ggggtcgggc actgactctg     1740

agtcgccagt ctgcccaaag ttgagcttct ttttagcggg ctgctggcct ttcttgccga     1800

tgcccgtgga ggagtcgggg gattctatgg gtctcttctt tccggaagcc gtcttagcgc     1860

cttcctcaac cagaccgaga ggttcgagaa cccgcttctt ggcctggaag actgctcgcc     1920

cgaggttgcc cccaaaagac gtatcttctt gaagacgctc ctgaaactcg gcgtcggcgt     1980

ggttgtactt gaggtacggg ttgtccccct gctcgagctg cttgtcgtag gccttgtcgt     2040

gctcgagggc cgcggcgtct gcctcgttga ccggctctcc cttgtcgagt ccgttgaagg     2100

gtccgaggta cttgtagcca ggaagcacca gaccccggcc gtcgtcctgc ttttgctggt     2160

tggctttggg tttcggggct ccaggtttca agtcccacca ctcgcgaatg ccctcagaga     2220

ggttgtcctc gagccaatct ggaagataac catcggcagc catacctggt ttaagtcatt     2280

tattgctcag aaacacagtc atccaggtcc acgttgacca gatcgcaggc cgagcaagca     2340

atctcgggag cccgccccag cagatgatga atggcacaga gtttccgata cgtcctcttt     2400

ctgacgaccg gttgagattc tgacacgccg gggaaacatt ctgaacagtc tctggtcccg     2460

tgcgtgaagc aaatgttgaa attctgattc attctctcgc atgtcttgca gggaaacagc     2520

atctgaagca tgcccgcgtg acgagaacat ttgttttggt acctgtcggc aaagtccacc     2580

ggagctcctt ccgcgtctga cgtcgatgga tccgcgactg aggggcaagc ccgcttgggc     2640

tcgcttttat ccgcgtcatc gggggcgggt ctcttgttgg ctccaccctt tctgacgtag     2700

aactcatgcg ccacctcggt cacgtgatcc tgcgcccagc ggaagaactc tttgacttcc     2760

tgctttgtca ccttgccaaa gtcatgctcc agacggcggg tgagttcaaa tttgaacatc     2820

cggtcttgta acggctgctg gtgctcgaag gtggtgctgt tcccgtcaat cacggcgcac     2880

atgttggtgt tggaagtgac gatcacgggg gtgggatcga tctgggcgga cgacttgcac     2940

ttttggtcca cgcgcacctt gctgccgccg agaatggcct tggcggactc cacgaccttg     3000

gccgtcatct tgccctcctc ccaccagatc accatcttgt cgacgcaatc gttgaaggga     3060

aagttctcat tggtccagtt gacgcagccg aagggcgaat tc                        3102


<210>  145
<211>  728
<212>  PRT
<213>  Adeno-associated virus

<400>  145

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Arg Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Asn Gly Gln 
145                 150                 155                 160 


Pro Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210>  146
<211>  728
<212>  PRT
<213>  Adeno-associated virus

<400>  146

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Gly Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Arg Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Asn Gly Gln 
145                 150                 155                 160 


Pro Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asp Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210>  147
<211>  3106
<212>  DNA
<213>  Adeno-associated virus

<400>  147
gcggccgcga attcgccctt cgcagagacc aaagttcaac tgaaacgaat cagccggttt       60

attgattaac aagtaattac aggttacggg tgaggtaacg ggtgccaatg gggcgaggct      120

cagtataaac cccttcgttg ttgacagcaa attccacatt attagacttg gcataatttg      180

aggtgtactg aatctctgga ttccagcgtt tgctgttttc tttctgcagt tcccactcga      240

tctccacgct gacctggccg gtgctgtact gcgtgataaa tgaggcaaac ttggcaggag      300

taaacacctc tggaggatta gcaggtaccg gggtgttttt gatgagaatt tgaggaggcg      360

ggtgtttgag tccaaatccg cccatcaggg gagacgggtg aaagttgccg tccgtgtgag      420

gaattttggc ccagatggga ccctgcaggt acacgtcccg gttctgccag accatgccgg      480

gcagagcccc ctggctgttg acagtctgtg tctggggtcc ggccgtagac gattgcaggt      540

tgctggagac cacaccgtat tcttctgtag ccacgggatt ggtggttttg atctcctcct      600

cgctggtcat tagcacgttt tccagcgttg tcttgttggc agcccccgtt ttgccaaaaa      660

ccagcactcc gttgatggga aagaactggt cctcgtcgtc cttgttggtg gccatggcta      720

cgcccgggtt ggttaatgaa tttctaccat tcagatggta tttagtggcc ccggtccagg      780

caaagttact gttgttgttg ctgtctatgt tttttgacag tctctgctgc cgataacagg      840

gtccgggcag ccagttcttt gattgctcgg ccatggtgtt gggcccagcc tgatggaact      900

gcagctccct tgtggacccc gtagtgctct gggtccgggc caggtagtac aggtactggt      960

cgatgagggg attcatcagc cggtccaggc tctggctgtg cgcatagctg ctgtggaaag     1020

gcacttcctc aaaggtgtag ctgaattcaa agttatcgcc cgttctcagc atctgagaag     1080

gaaagtactc caggcagtag aaggaggaac gtcccacaga ctgactgccg ttgtttagag     1140

tcagatatcc gtactgagga atcatgaaca cgtccgcagg gaacggaggg aggcagccct     1200

ggtgcgcaga gccgaggacg tacggcagtt ggtactccga gtccgagaag acctgaatcg     1260

tgctggtaag gttattagcg atggtcgtaa cgccgtcgtt cgtcgtgacc tccttgacct     1320

ggatgttgaa caacttgaac cgcagctttc tgggccggaa tccccagttg ttgttgatga     1380

gtcgctgcca gtcacgtggt gagaagtggc agtggaatct gttgaagtca aaatagcccc     1440

agggggtgct gtagccgaag aagtggttgt cgttggtagc cccgctctga cttgatatct     1500

gcttgtagag gtggttgttg taggtgggca gggcccaggt gcgggtgctg gtggtgatga     1560

ctctgtcgcc cagccatgtg gaatcgcaat gccaatttcc ggaggcatta cccactccgt     1620

cggcgccttc gttattgtct gccattggtg cgccaccgcc tgcagccatt gtaccagatc     1680

ccagacctga gggcgcggcg ggaggttctc cgagaggttg ggggtcgggc actgactctg     1740

agtcgccagt ctgcccaaag ttgagcttct ttttagcggg cggctggccg ttcttgccga     1800

tgcccgtgga ggagtcgggg gattctatgg gtctcttctt tccaggagcc gtcttagcgc     1860

cttcctcaac cagaccgaga ggttcgagaa cccgcttctt ggcctggaag actgctcgcc     1920

cgaggttgcc cccaaaagac gtatcttctt gaagacgctc ctgaaactcg gcgtcggcgt     1980

ggttgtactt gaggtacggg ttgtccccct gctcgagctg cttgtcgtag gccttgtcgt     2040

gctcgagggc cgcggcgtct gcctcgttga ccggctctcc cttgtcgagt ccgttgaagg     2100

gtccgaggta cctgtagcca ggaagcacca gaccccggcc gtcgtcctgc ttttgctggt     2160

tggctttggg tttcggggct ccaggtttca agtcccacca ctcgcgaatg ccctcagaga     2220

ggttgccctc gagccaatct ggaagataac catcggcagc catacctggt ttaagtcatt     2280

tattgctcag aaacacagtc atccaggtcc acgttggcca gatcgcaggc cgagcaagca     2340

atctcgggag cccgccccag cagatgatga atggcacaga gtttccgata cgtcctcttt     2400

ctgacgaccg gttgagattc tgacacgccg gggaaacatt ctgaacagtc tctggtcccg     2460

tgcgtgaagc aaatgttgaa attctgattc attctctcgc atgtcttgca ggggaacagc     2520

atctgaagca tgcccgcgtg acgagaacat ttgttttggt acctgtcggc aaagtccacc     2580

ggagctcctt ccgcgtctga cgtcgatgga tccgcgactg aggggcaggc ccgcttgggc     2640

tcgcttttat ccgcgtcatc gggggcgggt ctcttgttgg ctccaccctt tctgacgtag     2700

aactcatacg ccacctcggt cacgtgatcc tgcgcccagc ggaagaactc tttgacttcc     2760

tgctttgtca ccttgccaaa gtcatgctcc agacggcggg tgagttcaaa tttgaacatc     2820

cggtcttgta acggctgctg gtgctcgaag gtggtgctgt tcccgtcaat cacggcgcac     2880

atgttggtgt tggaagtgac gatcacgggg gtgggatcga tctgggcgga cgacttgcac     2940

ttttggtcca cgcgcacctt gctgccgccg agaatggcct tggcggactc cacgaccttg     3000

gccgtcatcc tgccctcctc ccaccagatc accatcttgt cgacgcaatc gttgaaggga     3060

aagttctcat tggtccagtt gacgcagccg tagaaagggc gaattc                    3106


<210>  148
<211>  728
<212>  PRT
<213>  Adeno-associated virus

<400>  148

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Met Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Gly Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Gly Val Phe Thr Pro 
                645                 650                 655     


Ala Leu Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210>  149
<211>  3098
<212>  DNA
<213>  Adeno-associated virus

<400>  149
gaattcgccc ttcgcagaga ccaaagttca actgaaacga atcaaccggt ttattgatta       60

acaagtaatt acaggttacg ggtgaggtaa cgggtgccaa tggggcgagg ctcagtataa      120

accccttcgt tgttgacagc aaattccaca ttattagact tggcataatt tgaggtgtac      180

tgaatctctg gattccagcg tttgctgttt tctttctgca gttcccactc gatctccacg      240

ctgacctggc cggtgctgta ctgcgtgata aatgaggcaa actaggcagg agtaaacacc      300

cctggaggat tagcaggtac cggggtgttt ttgatgagaa tttgaggagg cgggtgtttg      360

agtccaaatc cgcccatcag gggagacggg tgaaagttgc cgtccgtgtg aggaattttg      420

gcccagatgg gaccctgcag gtacacgtcc cggttctgcc agaccatgcc gggcagagcc      480

ccctggctgt tgacagtctg tgtctggggt ccggccgtag acgattgcag gttgctggag      540

accacaccgt attcttctgt agccacggga ttggtggttt tgatctcctc ctcgctggtc      600

attagcacgt tttccagcgt tgtcttgttg gcagcccccg ttttgccaaa aaccagcact      660

ccgttgatgg gaaagaactg gccctcgtcg tccttgttgg tggccatggc tacgcccggg      720

ttggttaatg aatttctacc attcagatgg tatttagtgg ccccggtcca ggcaaagtta      780

ctgttgttgt tgctgtctat gttttttgac agtctctgct gccgataaca gggtccgggc      840

agccagttct ttgattgctc ggccatggtg ttgggcccag cctgatggaa ctgcagctcc      900

cttgtggacc ccgtagtgct ctgggtccgg gccaggtagt acaggtactg gtcgatgagg      960

ggattcatca gccggtccag gctctggctg tgcgcatagc tgctgtggaa aggcacttcc     1020

tcaaaggtgt agctgaattc aaagttattg cccgttctca gcatctgaga aggaaagtac     1080

tccaggcagt agaaggagga acgtcccata gactgactgc cgttgtttag agtcagatat     1140

ccgtactgag gaatcatgaa cacgtccgca gggaacggag ggaggcagcc ctggtgcgca     1200

gagccgagga cgtacggcag ttggtactcc gagtccgaga agacctgaat cgtgctggta     1260

aggttattag cgatggtcgt aacgccgtcg ttcgtcgtga cctccttgac ctggatgttg     1320

aacaacttga accgcagctt tctgggccgg aatccccagt tgttgttgat gagtcgctgc     1380

cagtcacgtg gtgagaagtg gcagtggaat ctgttgaagt caaaatagcc ccagggggtg     1440

ctgtagccga agaagtggtt gtcgttggta gccccgctct gacttgatat ctgcttgtag     1500

aggtggttgt tgtaggtggg cagggcccag gtgcgggtgc tggtggtgat gactctgtcg     1560

cccagccatg tggaatcgca atgccaattt ccggaggcat tacccactcc gtcggcgcct     1620

tcgttattgt ctgccattgg tgcgccaccg cctgcagcca ttgtaccaga tcccagacct     1680

gagggcgcgg cgggaggttc tccgagaggt tgggggtcgg gcactgactc tgagtcgcca     1740

gtctgcccaa agttgagctt ctttttagcg ggctgctggc ctttcttgcc gatgcccgtg     1800

gaggagtcgg gggattctat gggtctcttc tttccaggag ccgtcttagc gccttcctca     1860

accagaccga gaggttcgag aacccgcttc ttggcctgga agactgctcg cccgaggttg     1920

cccccaaaag acgtatcttc ttgaagacgc tcctgaaact cagcgtcggc gtggttgtac     1980

ttgaggtacg ggttgtcccc ctgctcgagc tgcttgtcgt aggccttgtc gtgctcgagg     2040

gccgcggcgt ctgcctcgtt gaccggctct cccttgtcga gtccgttgaa gggtccgagg     2100

tacttgtagc caggaagcac cagaccccgg ccgtcgtcct gcttttgctg gttggctttg     2160

ggtttcgggg ctccaggttt caagtcccac cactcgcgaa tgccctcaga gaggttgtcc     2220

tcgagccaat ctggaagata accatcggca gccatacctg gtttaagtca tttattgctc     2280

agaaacacag tcatccaggt ccacgttgac cagatcgcag gccgagcaag caatctcggg     2340

agcccgcccc agcagatgat gaatggcaca gagtttccga tacgtcctct ttctgacgac     2400

cggttgagat tctgacacgc cggggaaaca ttctgaacag tctctggtcc cgtgcgtgaa     2460

gcaaatgttg aaattctgat tcattctctc gcatgtcttg cagggaaaca gcatctgaag     2520

catgcccgcg tgacgagaac atttgttttg gtacctgtcg gcaaagtcca ccggagctcc     2580

ttccgcgtct gacgtcgatg gatccgcgac tgaggggcag gcccgcttgg gctcgctttt     2640

atccgcgtca tcgggggcgg gcctcttgtt ggctccaccc tttctgacgt agaactcatg     2700

cgccacctcg gtcacgtgat cctgcgccca gcggaagaac tctttgactt cctgctttgt     2760

caccttgcca aagtcctgct ccagacggcg ggtgagttca aatttgaaca tccggtcttg     2820

taacggctgc tggtgctcga aggtggtgct gttcccgtca atcacggcgc acatgttggt     2880

gttggaagtg acgatcacgg gggtgggatc gatctgggcg gacgacttgc acttttggtc     2940

cacgcgcacc ttgctgccgc cgagaatggc cttggcggac tccacgacct tggccgtcat     3000

cttgccctcc tcccaccaga tcaccatctt gtcgacgcaa tcgttgaagg gaaagttctc     3060

attggtccag ttgacgcagc cgtagaaagg gcgaattc                             3098


<210>  150
<211>  2187
<212>  DNA
<213>  Adeno-associated virus

<400>  150
atggctgccg atggttatct tccagattgg ctcgagggca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aggtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

aagcagctcg agcaggggga caacccgtac ctcaagtaca accacgccga cgccgagttt      300

caggagcgtc ttcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gacccataga atcccccgac tcctccacgg gcatcggcaa gaacggccag      480

ccgcccgcta aaaagaagct caactttggg cagactggcg actcagagtc agtgcccgac      540

ccccaacctc tcggagaacc tcccgccgcg ccctcaggtc tgggatctgg tacaatggct      600

gcaggcggtg gcgcaccaat ggcagacaat aacgaaggcg ccgacggagt gggtaatgcc      660

tccggaaatt ggcattgcga ttccacatgg ctgggcgaca gagtcatcac caccagcacc      720

cgcacctggg ccctgcccac ctacaacaac cacctctaca agcagatatc aagtcagagc      780

ggggctacca acgacaacca cttcttcggc tacagcaccc cctggggcta ttttgacttc      840

aacagattcc actgccactt ctcaccacgt gactggcagc gactcatcaa caacaactgg      900

ggattccggc ccagaaagct gcggttcaag ttgttcaaca tccaggtcaa ggaggtcacg      960

acgaacgacg gcgttacgac catcgctaat aaccttacca gcacgattca ggtcttctcg     1020

gactcggagt accaactgcc gtacgtcctc ggctctgcgc accagggctg cctccctccg     1080

ttccctgcgg acgtgttcat gattcctcag tacggatatc tgactctaaa caacggcagt     1140

cagtctgtgg gacgttcctc cttctactgc ctggagtact ttccttctca gatgctgaga     1200

acgggcgata actttgaatt cagctacacc tttgaggaag tgcctttcca cagcagctat     1260

gcgcacagcc agagcctgga ccggctgatg aatcccctca tcgaccagta cctgtactac     1320

ctggcccgga cccagagcac tacggggtcc acaagggagc tgcagttcca tcaggctggg     1380

cccaacacca tggccgagca atcaaagaac tggctgcccg gaccctgtta tcggcagcag     1440

agactgtcaa aaaacataga cagcaacaac aacagtaact ttgcctggac cggggccact     1500

aaataccatc tgaatggtag aaattcatta accaacccgg gcgtagccat ggccaccaac     1560

aaggacgacg aggaccagtt ctttcccatc aacggagtgc tggtttttgg caaaacgggg     1620

gctgccaaca agacaacgct ggaaaacgtg ctaatgacca gcgaggagga gatcaaaacc     1680

accaatcccg tggctacaga agaatacggt gtggtctcca gcaacctgca atcgtctacg     1740

gccggacccc agacacagac tgtcaacagc cagggggctc tgcccggcat ggtctggcag     1800

aaccgggacg tgtacctgca gggtcccatc tgggccaaaa ttcctcacac ggacggcaac     1860

tttcacccgt ctcccctgat gggcggattt ggactcaaac acccgcctcc tcaaattctc     1920

atcaaaaaca ccccggtacc tgctaatcct ccagaggtgt ttactcctgc caagtttgcc     1980

tcatttatca cgcagtacag caccggccag gtcagcgtgg agatcgagtg ggaactgcag     2040

aaagaaaaca gcaaacgctg gaatccagag attcagtaca cctcaaatta tgccaagtct     2100

aataatgtgg aatttgctgt caacaacgaa ggggtttata ctgagcctcg ccccattggc     2160

acccgttacc tcacccgtaa cctgtaa                                         2187


<210>  151
<211>  728
<212>  PRT
<213>  Adeno-associated virus

<400>  151

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Gly Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Arg Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Asn Gly Gln 
145                 150                 155                 160 


Pro Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asp Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210>  152
<211>  728
<212>  PRT
<213>  Adeno-associated virus

<400>  152

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Arg Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Asn Gly Gln 
145                 150                 155                 160 


Pro Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asp Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210>  153
<211>  728
<212>  PRT
<213>  Adeno-associated virus

<400>  153

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Arg Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Asn Gly Gln 
145                 150                 155                 160 


Pro Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210>  154
<211>  728
<212>  PRT
<213>  Adeno-associated virus

<400>  154

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Asn Gly Gln 
145                 150                 155                 160 


Pro Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210>  155
<211>  728
<212>  PRT
<213>  Adeno-associated virus

<400>  155

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210>  156
<211>  2215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  156
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg ctgcaggcgg tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagagactca gcttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcccac     1080

cagggctgcc tgcctccgtt cccggcggac gtgttcatga ttccccagta cggctaccta     1140

acactcaaca acggtagtca ggccgtggga cgctcctcct tctactgcct ggaatacttt     1200

ccttcgcaga tgctgagaac cggcaacaac ttccagttta cttacacctt cgaggacgtg     1260

cctttccaca gcagctacgc ccacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacgac aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca gcagcgagta tcaaagacat ctgcggataa caacaacagt     1500

gaatactcgt ggactggagc taccaagtac cacctcaatg gcagagactc tctggtgaat     1560

ccgggcccgg ccatggcaag ccacaaggac gatgaagaaa agtttttttc ctcagagcgg     1620

ggttctcatc tttgggaagc aaggctcaga gaaaacaaat gtggacattg aaaaggtcat     1680

gattacagac gaagaggaaa tcaggacaac caatcccgtg gctacggagc agtatggttc     1740

tgtatctacc aacctccaga gaggcaacag acaagcagct accgcagatg tcaacacaca     1800

aggcgttctt ccaggcatgg tctggcagga cagagatgtg taccttcagg ggcccatctg     1860

ggcaaagatt ccacacacgg acggacattt tcacccctct cccctcatgg gtggattcgg     1920

acttaaacac cctccgcctc agatcctgat caagaacacg cctgtacctg cggatcctcc     1980

gaccaccttc aaccagtcaa agctgaactc tttcatcacc cagtattcta ctggccaagt     2040

cagcgtggag atcgagtggg agctgcagaa ggaaaacagc aagcgctgga accccgagat     2100

ccagtacacc tccaactact acaaatctac aagtgtggac tttgctgtta atacagaagg     2160

cgtgtactct gaaccccgcc ccattggcac ccgttacctc acccgtaatc tgtaa          2215


<210>  157
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  157

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ala Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Lys Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Thr Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp 
                485                 490                 495     


Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala 
            580                 585                 590         


Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  158
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  158

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ala Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Lys Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Thr Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp 
                485                 490                 495     


Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Gln Gly Asn Thr Gln Ala 
            580                 585                 590         


Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  159
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  159

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ala Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Thr Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp 
                485                 490                 495     


Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Gln Gly Asn Thr Gln Ala 
            580                 585                 590         


Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  160
<211>  729
<212>  PRT
<213>  Adeno-associated virus

<400>  160

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Asp Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Thr Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Ser Ser Ser Gly Ala Thr Asn Asp Asn His Tyr Phe Gly Tyr 
            260                 265                 270         


Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe 
        275                 280                 285             


Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg 
    290                 295                 300                 


Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val 
305                 310                 315                 320 


Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser Phe Glu Asp Val Pro 
                405                 410                 415     


Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn 
            420                 425                 430         


Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr 
        435                 440                 445             


Thr Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr 
    450                 455                 460                 


Met Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln 
465                 470                 475                 480 


Gln Arg Leu Ser Lys Asn Leu Asp Phe Asn Asn Asn Ser Asn Phe Ala 
                485                 490                 495     


Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr 
            500                 505                 510         


Asn Pro Gly Ile Pro Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe 
        515                 520                 525             


Phe Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn 
    530                 535                 540                 


Lys Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys 
545                 550                 555                 560 


Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn 
                565                 570                 575     


Leu Gln Ser Ser Thr Ala Gly Pro Gln Ser Gln Thr Ile Asn Ser Gln 
            580                 585                 590         


Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln 
        595                 600                 605             


Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro 
    610                 615                 620                 


Ser Pro Leu Met Gly Gly Phe Gly Leu Glu His Pro Pro Pro Gln Ile 
625                 630                 635                 640 


Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr 
                645                 650                 655     


Pro Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
            660                 665                 670         


Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp 
        675                 680                 685             


Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val 
    690                 695                 700                 


Glu Phe Ala Val Asn Pro Asp Gly Val Tyr Thr Glu Pro Arg Pro Ile 
705                 710                 715                 720 


Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 


<210>  161
<211>  3075
<212>  DNA
<213>  Adeno-associated virus

<400>  161
tgagaacttt cctttcaacg attgcgtcgg acaagatggt gatctggtgg gaggagggga       60

agatgaccgc caaggtcgtg gagtcggcca aagccattct tggaggaagc aaggtgcgtg      120

tggaccagaa atgcaagtcc tcggcccaga tagacccgac tcccgtgatc gtcacctcca      180

acaccaacat gtgcgccgtg attgacggga actcaacgac cttcgagcac cagcagccgt      240

tgcaagaccg gatgttcaaa tttgaactta cccgccgtct ggatcatgac tttggaaagg      300

tcaccaagca ggaagtgaaa gactttttcc ggtgggcaaa ggatcacgtg gttgaggtgg      360

agcatgaatt ctacgtcaaa aagggtggag ctaagaaaag acccgccccc agtgacgcag      420

atataagtga gcccaaacgg gcgcgcgagt cagttgcgca gccatcaacg tcagacgcgg      480

aagcttcgat caactacgcg gacaggtacc aaaaacaaat gttctcgtca cgtgggcatg      540

aatctgatgc tgtttccctg cagacaatgc gagagaatga atcagaattc aaatatctgc      600

ttcactcacg gacagaaaga ctgtttagag tgctttcccg tgtcagaatc tcaacccgtt      660

tctgtcgtca aaaaggcgta tcagaaactg tgctacattc atcatatcat gggaaaggtg      720

ccagacgctt gcactgcctg cgatctggtc aatgtggatt tggatgactg catctctgaa      780

caataaatga tttaaatcag gtatggctgc cgatggttat cctccagatt ggctcgagga      840

cactctctct gaagggataa gacagtggtg gaagctcaaa cctggcccac caccaccaaa      900

gcccgcagag cggcataagg acgacagcag gggtcttgtg cttcctgggt acaagtacct      960

cggacccttc aacggactcg acaaggggga gccggtcaac gaggcagacg ccgcggccct     1020

cgagcacgac aaggcctacg accggcagct cgacagcgga gacaacccgt acctcaagta     1080

caaccacgcc gacgcagagt ttcaggagcg ccttaaagaa gatacgtctt ttgggggcaa     1140

cctcggacga gcagtcttcc aggcgaaaaa gagggttctt gaacctctgg gcctggttga     1200

ggaacctgtt aagacggctc cgggaaaaaa gaggccggta gagcactctc ctgtggagcc     1260

agactcctcc tcgggaaccg gaaaagcggg ccagcggcct gcaagaaaaa gattaaattt     1320

tggtcagact ggagacgcag actccgtacc tgacccccag cctctcggac agccaccagc     1380

agccccctct ggtctgggat ctactacaat ggctacaggc agtggcgcac caatggcaga     1440

caataacgag ggtgccgatg gagtgggtaa ttcctcagga aattggcatt gcgattccca     1500

atggctgggc gacagagtca tcaccaccag cacccgaacc tgggccctgc ccacatacaa     1560

caaccacctc tacaagcaaa tctccagcca atcaggagcc agcaacgaca accactactt     1620

tggctacagc accccctggg ggtattttga cttcaacaga ttccactgcc acttttcacc     1680

acgtgactgg caaagactca tcaacaacaa ctggggattc cggcccaaaa gactcaactt     1740

caagctcttt aatattcaag tcaaagaggt cacgcagaat gacggtacga cgacgattgc     1800

caataacctt accagcacgg ttcaggtgtt tactgactcg gagtaccagc tcccgtacgt     1860

cctgggctcg gcgcatcaag gatgcctccc gccgtttcca gcggacgtct tcatggtccc     1920

acagtatgga tacctcaccc tgaacaacgg gagtcaggcg gtaggacgct cttcctttta     1980

ctgcctggag tactttcctt ctcagatgct gcgtactgga aacaactttc agttcagcta     2040

cacttttgaa gacgtgcctt tccacagcag ctacgctcac agccagagtc tggatcggct     2100

gatgaatcct ctgatcgacc agtacctgta ttatctgaac aagacacaaa caaatagtgg     2160

aactcttcag cagtctcggc tactgtttag ccaagctgga ccaaccaaca tgtctcttca     2220

agctaaaaac tggctgcctg gaccttgcta cagacagcag cgtctgtcaa aacaggcaaa     2280

cgacaacaac aacagcaact ttccctggac tgcagctaca aagtatcatc taaatggccg     2340

ggactcgttg gttaatccag gaccagctat ggccagtcac aaggatgacg aagaaaagtt     2400

tttccccatg catggaaccc tgatatttgg taaacaagga acaaatgcca acgacgcgga     2460

tttggaaaat gtcatgatta cagatgaaga agaaatcagg gccaccaatc ccgtggctac     2520

ggagcagtac gggactgtgt caaataattt gcaaaactca aacactggtc caactactgg     2580

aactgtcaat cgccaaggag cgttacctgg tatggtgtgg caggatcgag acgtgtacct     2640

gcagggaccc atttgggcca agattcctca caccgatgga cactttcatc cttctccact     2700

gatgggaggt tttggactca aacacccgcc tcctcagatc atgatcaaaa acactcccgt     2760

tccagccaat cctcccacaa acttcagttc tgccaagttt gcttctttca tcacacagta     2820

ttccacggga caggtcagcg tggagatcga gtgggagctg cagaaggaga acagcaaacg     2880

ctggaatccc gaaattcagt acacttccaa ctacaacaag tctgttaatg tggactttac     2940

tgtggacact aatggtgtgt attcagagcc tcgccccatt ggcaccagat acctgactcg     3000

taatctgtaa ttgcttgtta atcaataaac cgtttaattc gtttcagttg aactttggtc     3060

tctgcgaagg gcgaa                                                      3075


<210>  162
<211>  3142
<212>  DNA
<213>  Adeno-associated virus

<400>  162
aaaacgacgg gccagtgatt gtaatacgac tcactatagg gcgaaattga aattagcggc       60

cgcgaattcg cctttcgcag agaccaaagt tcaactgaaa cgaattaaac ggtttattga      120

ttaacaagca attacagatt acgagtcagg tatctggtgc caatggggcg aggctctgaa      180

tacacaccat tagtgtccac agtaaagtcc acattaacag acttgttgta gttggaagtg      240

tactgaattt cgggattcca gcgtttgctg ttctccttct gcagctccca ctcgatctcc      300

acgctgacct gtcccgtgga atactgtgtg atgaaagaag caaacttggc agaactgaag      360

tttgtgggag gattggctgg aacgggagtg tttttgatca tgatctgagg aggcgggtgt      420

ttgagtccaa aacctcccat cagtggagaa ggatgaaagt gtccatcggt gtgaggaatc      480

ttggcccaaa tgggtccctg caggtacacg tctcgatcct gccacaccat accaggtaac      540

gctccttggt gattgacagt tccagtagtt ggaccagtgt ttgagttttg caaattattt      600

gacacagtcc cgtactgctc cgtagccacg ggattggtgg ccctgatttc ttcttcatct      660

gtaatcatga cattttccaa atccgcgtcg ttggcatttg ttccttgttt accaaatatc      720

agggttccat gcatggggaa aaacttttct tcgtcatcct tgtgactggc catagctggt      780

cctggattaa ccaacgagtc ccggccattt agatgatact ttgtagctgc agtccaggga      840

aagttgctgt tgttgttgtc gtttgcctgt tttgacagac gctgctgtct gtagcaaggt      900

ccaggcagcc agtttttagc ttgaagagac atgttggttg gtccagcttg gctaaacagt      960

agccgagact gctgaagagt tccactattt gtttgtgtct tgttcagata atacaggtac     1020

tggtcgatca gaggattcat cagccgatcc agactctggc tgtgagcgta gctgctgtgg     1080

aaaggcacgt cttcaaaagt gtagctgaac tgaaagttgt ttccagtacg cagcatctga     1140

gaaggaaagt actccaggca gtaaaaggaa gagcgtccta ccgcctgact cccgttgttc     1200

agggtgaggt atccatactg tgggaccatg aagacgtccg ctggaaacgg cgggaggcat     1260

ccttgatgcg ccgagcccag gacgtacggg agctggtact ccgagtcagt aaacacctga     1320

accgtgctgg taaggttatt ggcaatcgtc gtcgtaccgt cattctgcgt gacctctttg     1380

acttgaatat taaagagctt gaagttgagt cttttgggcc ggaatccccg gttgttgttg     1440

acgagtcttt gccagtcacg tggtgaaaag tggcagtgga atctgttgaa gtcaaaatac     1500

ccccaggggg tgctgtagcc aaagtagtgg ttgtcgttgc tggctcctga ttggctggag     1560

atttgcttgt agaggtggtt gttgtatgtg ggcagggccc aggttcgggt gctggtggtg     1620

atgactctgt cgcccagcca ttgggaatcg caatgccaat ttcctgagga attacccact     1680

ccatcggcac cctcgttatt gtctgccatt ggtgcgccac tgcctgtagc cattgtagta     1740

gatcccagac cagagggggc tgctggtggc tgtccgagag gctgggggtc aggtacggag     1800

tctgcgtctc cagtctgacc aaaatttaat ctttttcttg caggctgctg gcccgctttt     1860

ccggttcccg aggaggagtc tggctccaca ggagagtgct ctaccggcct cttttttccc     1920

ggagccgtct taacaggctc ctcaaccagg cccagaggtt caagaaccct ctttttcgcc     1980

tggaagactg ctcgtccgag gttgccccca aaagacgtat cttctttaag gcgctcctga     2040

aactctgcgt cggcgtggtt gtacttgagg tacgggttgt ctccgctgtc gagctgccgg     2100

tcgtaggcct tgtcgtgctc gagggccgcg gcgtctgcct cgttgaccgg ctcccccttg     2160

tcgagtccgt tgaagggtcc gaggtacttg tacccaggaa gcacaagacc cctgctgtcg     2220

tccttatgcc gctctgcggg ctttggtggt ggtgggccag gtttgagctt ccaccactgt     2280

cttattcctt cagagagagt gtcctcgagc caatctggaa gataaccatc ggcagccata     2340

cctgatttaa atcatttatt gttcagagat gcagtcatcc aaatccacat tgaccagatc     2400

gcaggcagtg caagcgtctg gcacctttcc catgatatga tgaatgtagc acagtttctg     2460

atacgccttt ttgacgacag aaacgggttg agattctgac acgggaaagc actctaaaca     2520

gtctttctgt ccgtgagtga agcagatatt tgaattctga ttcattctct cgcattgtct     2580

gcagggaaac agcatcagat tcatgcccac gtgacgagaa catttgtttt ggtacctgtc     2640

cgcgtagttg atcgaagctt ccgcgtctga cgtcgatggc tgcgcaactg actcgcgcgc     2700

ccgtttgggc tcacttatat ctgcgtcact gggggcgggt cttttcttag ctccaccctt     2760

tttgacgtag aattcatgct ccacctcaac cacgtgatcc tttgcccacc ggaaaaagtc     2820

tttcacttcc tgcttggtga cctttccaaa gtcatgatcc agacggcggg taagttcaaa     2880

tttgaacatc cggtcttgca acggctgctg gtgctcgaag gtcgttgagt tcccgtcaat     2940

cacggcgcac atgttggtgt tggaggtgac gatcacggga gtcgggtcta tctgggccga     3000

ggacttgcat ttctggtcca cacgcacctt gcttcctcca agaatggctt tggccgactc     3060

cacgaccttg gcggtcatct tcccctcctc ccaccagatc accatcttgt cgacgcaatg     3120

gtaaaaggaa agttctcatt gg                                              3142


<210>  163
<211>  735
<212>  PRT
<213>  Adeno-associated virus 2

<400>  163

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asp Lys Ala Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 735 


<210>  164
<211>  740
<212>  PRT
<213>  Adeno-associated virus 2

<400>  164

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu Leu 
                725                 730                 735     


Leu Ala Ala Ala 
            740 


<210>  165
<211>  734
<212>  PRT
<213>  Adeno-associated virus 2

<400>  165

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Met Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Ile Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 


<210>  166
<211>  734
<212>  PRT
<213>  Adeno-associated virus 2

<400>  166

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Glu Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 


<210>  167
<211>  739
<212>  PRT
<213>  Adeno-associated virus 2

<400>  167

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu Leu 
                725                 730                 735     


Leu Ala Ala 
            


<210>  168
<211>  725
<212>  PRT
<213>  Adeno-associated virus 2

<400>  168

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro 
                725 


<210>  169
<211>  707
<212>  PRT
<213>  Adeno-associated virus 2

<400>  169

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Cys Ile Tyr Gln Pro Pro Glu Arg Gln Gln Thr Ser Ser Tyr 
            580                 585                 590         


Arg Arg Cys Gln His Thr Arg Arg Ser Ser Arg His Gly Leu Ala Gly 
        595                 600                 605             


Gln Arg Cys Val Pro Ser Gly Ala His Leu Gly Lys Asp Ser Thr His 
    610                 615                 620                 


Gly Arg Thr Phe Ser Pro Leu Ser Pro His Gly Trp Ile Arg Thr Thr 
625                 630                 635                 640 


Pro Ser Ser Thr Asp Ser His Gln Glu His Pro Gly Thr Cys Glu Ser 
                645                 650                 655     


Phe Asp His Leu Gln Cys Gly Lys Val Cys Phe Leu His His Thr Val 
            660                 665                 670         


Leu His Gly Thr Gly Gln Arg Gly Asp Arg Val Arg Ala Ala Glu Gly 
        675                 680                 685             


Lys Gln Gln Thr Leu Glu Ser Arg Asn Ser Val His Phe Gln Leu Gln 
    690                 695                 700                 


Gln Val Cys 
705         


<210>  170
<211>  739
<212>  PRT
<213>  Adeno-associated virus 2

<400>  170

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu Leu 
                725                 730                 735     


Leu Ala Ala 
            


<210>  171
<211>  737
<212>  PRT
<213>  Adeno-associated virus 2

<400>  171

Met Ala Ser Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg 
        435                 440                 445             


Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser 
    450                 455                 460                 


Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn 
                485                 490                 495     


Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala 
            580                 585                 590         


Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His His Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


Leu 
    


<210>  172
<211>  741
<212>  PRT
<213>  Adeno-associated virus 2

<400>  172

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ser Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Leu Ala Asn His Asn 
            580                 585                 590         


Asn Thr Thr Asn Ala Arg Gln Ala Ala Thr Ala Asp Val Asn Thr Gln 
        595                 600                 605             


Gly Val Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln 
    610                 615                 620                 


Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro 
625                 630                 635                 640 


Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile 
                645                 650                 655     


Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Ser Thr Thr Phe Ser 
            660                 665                 670         


Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
        675                 680                 685             


Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp 
    690                 695                 700                 


Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Ile Asn Val 
705                 710                 715                 720 


Asp Phe Thr Val Asp Thr Asn Gly Val Tyr Ser Glu Pro Arg Pro Ile 
                725                 730                 735     


Gly Thr Arg Tyr Leu 
            740     


<210>  173
<211>  730
<212>  PRT
<213>  Adeno-associated virus 2

<400>  173

Met Ala Ser Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Asn Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg 
                725                 730 


<210>  174
<211>  735
<212>  PRT
<213>  Adeno-associated virus 2


<220>
<221>  misc_feature
<222>  (239)..(239)
<223>  Xaa can be any naturally occurring amino acid

<400>  174

Met Ala Ser Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Xaa Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Asn Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 735 


<210>  175
<211>  733
<212>  PRT
<213>  Adeno-associated virus 2

<400>  175

Met Ala Ser Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Leu Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Asn Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr 
                725                 730             


<210>  176
<211>  734
<212>  PRT
<213>  Adeno-associated virus 2

<400>  176

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Cys Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Asn Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Asn Gln Ser Gly Ser Ala Gln Asn Asn Asp Leu Leu Phe Ser Arg 
    450                 455                 460                 


Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn Gly 
            500                 505                 510         


Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly Lys 
    530                 535                 540                 


Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg Phe 
                565                 570                 575     


Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala Thr 
            580                 585                 590         


Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu Tyr 
705                 710                 715                 720 


Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 


<210>  177
<211>  734
<212>  PRT
<213>  Adeno-associated virus 2

<400>  177

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Ser Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Ile Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 


<210>  178
<211>  738
<212>  PRT
<213>  Adeno-associated virus 2

<400>  178

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Gly Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu Leu 
                725                 730                 735     


Arg Pro 
        


<210>  179
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  179
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcagagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaaaaga ttaaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acatacaaca accacctcta caagcaaatc      780

tccagccaat caggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaaaaga ctcaacttca agctctttaa tattcaagtc      960

aaagaggtca cgcagaatgg cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tgggctcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttcag ttcagctaca cttttgaaga cgtgcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa gacacaaaca aatagtggaa ctcttcagca gtctcggcta     1380

ctgtttagcc aagctggacc aaccaacatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctgtcaaaa caggcaaacg gcaacaacaa cagcaacttt     1500

ccctggactg cagctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagtcacaa ggatgacgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgccaac gacgcggatt tggaaaatgt catgattaca     1680

gatgaagaag aaatcagggc caccaatccc gtggctacgg agcagtacgg gactgtgtca     1740

aataatttgc aaaactcaaa cactggtcca actactggaa ctgtcaatca ccaaggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactga cgggaggttt tggactcaaa     1920

cacccgcctc ctcagatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  180
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  180

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Gly Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Thr Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Asn Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Gly Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Ala Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Thr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Thr Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  181
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  181
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc tcgcagagcg gcatcaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aaaggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc atcagcctgc gagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag cccccacaag tctgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tccagccaat caggagcctc gaacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgtcac ttctccccac gtgattggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc acggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caaccttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccggctga tgaatcctct gatcgaccag     1320

tatctatatt atctgaacag gacacaatca aatagtggaa ctcttcagca gtctaggcta     1380

ctgtttagcc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctttcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagccacaa agacgatgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggagcatgt tatgattaca     1680

gatgaagaag aaatcaggac caccaatcct gtggctacag agcagtacgg aaacgtgtca     1740

aataatttgc aaaactcaaa tactggtcca actacagaaa atgtcaatca ccagggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgacggaca ctttcaccct tctccactga tgggaggttt tggactcaaa     1920

cacccgcctc ctcaaatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

tacagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggcca ggtcagcgtg     2040

gagattgagt gggagctgcg gaaggagaac agcaaacgct ggaaccccga gatccagtat     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  182
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  182

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Leu Ala Glu Arg His Gln Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Thr Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Leu Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu His Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Asn Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Glu Asn Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Tyr Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Arg Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  183
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  183
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcatcaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aaaggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggcc atcagcctgc gagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag cccccacaag tttgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tccagccaat caggagcctc gaacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgtcac ttctccccac gtgattggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaggaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccggctga tgaatcctct gatcgaccag     1320

tatctatatt atctgaacag gacacaatca aatagtggaa ctcttcagca gtctaggcta     1380

ctgtttagcc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctttcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtatcgtcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagccacaa agacgatgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggagcatgt tatgattaca     1680

gatgaagaag aaatcaggac caccaatcct gtggctacag agcagtacgg aaacgtgtca     1740

aataatttgc aaaactcaaa tactggtcca actacagaaa atgtcaatca ccagggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgacggaca ctttcaccct tctccactga tgggaggttt tggactcaaa     1920

cacccgcctc ctcaaatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggcca ggtcagcgtg     2040

gagattgagt gggagctgca gaaggagaac agcaaacgct ggaaccccga gatccagtat     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  184
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  184

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Gln Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr Arg Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu His Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Asn Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Glu Asn Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  185
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  185
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcatcaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aaaggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggcc atcagcctgc gagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag cccccacaag tttgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tccagccaat caggagcctc gaacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgtcac ttctccccac gtgattggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgccct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccggctga tgaatcctct gatcgaccag     1320

tatctatatt atctgaacag gacacaatca aatagtggaa ctcttcagca gtctaggcta     1380

ctgtttagcc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctttcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagccacaa agacgatgaa gaaaagtttt tccccatgca tgggaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggagcatgt tatgattaca     1680

gatgaagaag aaatcaggac caccaatcct gtggctacag agcagtacgg aaacgtgtca     1740

aataatttgc aaaactcaaa tactggtcca actacagaaa atgtcaatca ccagggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgacggaca ctttcaccct tctccactga tgggaggttt tggactcaaa     1920

cacccgcctc ctcaaatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggcca ggtcagcgtg     2040

gagattgagt gggagctgca gaaggagaac agcaaacgct ggaaccccga gatccagtat     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  186
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  186

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Gln Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Pro Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu His Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Asn Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Glu Asn Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  187
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  187
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcaaaaaaga gggttcttga acctctgggc ctggttgagg agcctgttaa aacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaaaaga ttgaatttcg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg cttcaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacttg ggccctgccc acctacaaca accatctcta caagcaaatc      780

tccagccaat caggagccag caacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgca gtccaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg ccagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctgc agggcggcaa cacacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttctttcatc acacagtatt ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga gatccagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg ttgacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  188
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  188

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Gly Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  189
<211>  3161
<212>  DNA
<213>  Adeno-associated virus

<400>  189
gattgaattt agcggccgcg aattcgccct tgctgcgtca actggaccaa tgagaacttt       60

ccattcaatg attgcgtcga caagatggtg atctggtggg aggagggaaa gatgaccgcc      120

aaggtcatgg agtcggccaa agccattctc ggaggaagca aggtgcgcgt ggaccagaaa      180

tgtaagtcct cggcccagat agacccgact cccgtgattg tcacctccaa caccaacatg      240

tgcgccgtga ttgacgggaa ctcaacgacc ttcgagcacc agcagccgtt gcaagaccgg      300

atgttcaaat ttgaactcac ccgccgtctg gatcatgact ttgggaaggt caccaagcag      360

gaagtcaaag actttttccg gtgggcaaag gatcacgtgg ttgaggtgga gcatgaattc      420

tacgtcaaaa agggtggagc caagaaaaga cccgccccca gtgacgcaga tataagtgag      480

cccaaacggg cgcgcgggtc agttgcgcag ccatcgacgt cagacgcgga agcttcgatc      540

aactacgcgg acaggtacca aaacaaatgt tctcgtcacg tgggcatgaa tctgatgctg      600

tttccctgca gacaatgcga gagaatgaat caaaattcaa atatctgctt cactcacgga      660

cagaaggact gtttagagtg ctttcccgtg tcagaatctc aacccgtttc tgtcgtcaaa      720

aaggcgtatc agaaactttg ctacattcat catatcatgg gaaaggtgcc agacgcttgc      780

actgcctgcg atctggtcaa tgtggatttg gatgactgca tctctgaaca ataaatgatt      840

taaatcaggt atggctgccg atggttatct tccagattgg ctcaaggaca ctctctctga      900

aggaataaga cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg      960

gcataaggac gacagcgggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa     1020

cggactcgac aagggagagc cggtcaacga ggcagacgcc gcggccctcg agtacgacaa     1080

ggcctacgac cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga     1140

cgcggagttt caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc     1200

agtcttccag gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa     1260

gacggctccg ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc     1320

gggaacagga aaagcgggcc agcagcctgc gagaaagaga ttgaattttg gtcagactgg     1380

agacgcagac tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg     1440

tctgggaact aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg     1500

cgccgacgga gtgggtaatt cctcgggaag ttggcattgc gattccacat ggatgggcga     1560

cagagtcatc accaccagca cccgaacctg ggctctgccc acctacaaca accatctgta     1620

caagcagatc tccagccaat caggagccag caacgacaac cactactttg gctacagcac     1680

cccttggggg tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca     1740

aagactcatc aacaacaact ggggattccg gcccaagaga ctcaacttca agctctttaa     1800

cattcaagtc aaggaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac     1860

cagcacggtt caggtgttta ctgactcgga gtaccagctc ccgtacgtcc ccggctcggc     1920

gcatcaagga tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata     1980

cctcaccctg aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta     2040

ctttccttct cagatgcttc gtaccggaaa caactttacc ttcagctaca cctttgagga     2100

tgttcctttc cacagcagct acgctcacag ccagagtttg gaccgtctca tgaatcctct     2160

catcgaccag tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgca     2220

gtccaggctt cagttttctc aggccggagc aagtgacatt cgggaccagt ctaggaactg     2280

gcttcctgga ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa     2340

cagtgaatac tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt     2400

gaatccgggc ccggccatgg ccagccacaa ggacgatgaa gaaaagtttt ttcctcaaag     2460

cggggttctc atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt     2520

catgattaca gacgaagagg aaatcagaac caccaatccc gtggccacgg agcagtatgg     2580

ttctgtatct accaacctcc agagcggcaa cacacaagca gctactgcag atgtcaacac     2640

acaaggcgtt cttccaggca tggtctggca ggacagagac gtgcacctgc aggggcctat     2700

ctgggcaaag attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt     2760

tggacttaaa caccctcctc cacagattct catcaagaac accccggtac ctgcaaatcc     2820

ttcgaccacc ttcagtgcgg caaagtttgc ttccttcatc acacagtatt ccacagggca     2880

ggtcagcgtg gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaaccccga     2940

gatccagtac acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa     3000

tggtgtgtat tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaatt     3060

gcttgttaat caataaaccg tttaattcgt ttcagttgaa ctttggtctc tgcgaagggc     3120

gaattcgttt aaaccctgca ggactagtcc ctttagtgag g                         3161


<210>  190
<211>  3162
<212>  DNA
<213>  Adeno-associated virus

<400>  190
gaattgaatt tagcggccgc gaattcgccc ttcgcagaga ccaaagttca actgaaacga       60

attaaacggt ttattgatta acaagcaatt acagattacg agtcaggtat ctggtgccaa      120

tggggcgagg ctctgaatac acgccattag tgtccacagt aaagtccaca ttaacagact      180

tgttgtagtt ggaagtgtac tgaatttcgg gattccagcg tttgctgttt tccttctgca      240

gctcccactc gatctccacg ctgacctgtc ccgtggagta ctgtgtgatg aaggaagcaa      300

actttgccgc actgaaggtg gtcgaaggat tcgcaggtac cggggtgttc ttgatgagaa      360

tctgtggagg agggtgttta agtccgaatc cacccatgag gggagagggg tgaaaatgtc      420

cgtccgtgtg tggaatcttt gcccagatgg gcccctgaag gtacacatct ctgtcctgcc      480

agaccatgcc tggaagaacg ccttgtgtgt tgacatctgc ggtagctgct tgtctgttgc      540

ctctctggag gttggtagat acagaaccgt actgctccgt agccacggga ttggttgtcc      600

tgatttcctc ttcgtctgta atcatgacct tttcaatgtc cacatttgtt ttctctgagc      660

cttgcttccc aaagatgaga accccgctct gaggaaaaaa cttttcttca ttgtccttgt      720

ggcttgccat ggccgggccc ggattcacca gagagtctct gccattgagg tggtacttgg      780

tagctccagt ccacgagtat tcactgttgt tgttatccgc agatgtcttt gatactcgct      840

gctggcggta acagggtcca ggaagccagt tcctagactg gtcccgaatg tcactcgctc      900

cggcctgaga aaactgaagc cttgactgcg tggtggttcc acttggagtg tttgttgtgc      960

tcaagtaata caggtactgg tcgatgagag gattcatgag acggtccaga ctctggctgt     1020

gagcgtagcc gctgtggaaa ggaacgtcct caaaagtgta gctgaaggta aagttgtttc     1080

cggtacgcag catctgagaa ggaaagtact ccaggcagta aaatgaagag cgtcctactg     1140

cctgactccc gttgttcagg gtgaggtatc catactgtgg caccatgaag acgtctgctg     1200

ggaacggcgg gaggcatcct tgatgcgccg agccgaggac gtacgggagc tggtactccg     1260

agtcagtaaa cacctgaacc gtgctggtaa ggttattggc aatcgtcgtc gtaccgtcat     1320

tctgcgtgac ctctttgact tgaatgttaa agagcttgaa gttgagtctc ttgggtcgga     1380

atccccagtt gttgttgatg agtctttgcc agtcacgtgg tgaaaagtgg cagtggaatc     1440

tgttgaagtc aaaatacccc caaggggtgc tgtagccaaa gtagtgattg tcgttcgagg     1500

ctcctgattg gctggaaatt tgtttgtaga ggtggttgtt gtaggtgggc agggcccagg     1560

ttcgggtgct ggtggtgatg actctgtcgc ccatccatgt ggaatcgcaa tgccaatttc     1620

ccgaggaatt acccactccg tcggcgccct cgttattgtc tgccattggt gcgccactgc     1680

ctgtagccat cgtattagtt cccagaccag agggggctgc tggtggctgt ccgagaggct     1740

gggggtcagg tactgagtct gcgtctccag tctgaccaaa attcaatctt tttcttgcag     1800

gctgctggcc cgcctttccg gttcccgagg aggagtctgg ctccacagga gagtgctcta     1860

ccggcctctt ttttcctgga gccgtcttga caggttcccc aaccaggccc agaggttcaa     1920

gaaccctctt tttcgcctgg aagactgctc gtccgaggtt gcccccaaaa gacgtatctt     1980

ctttaaggcg ctcctgaaac tccgcgtcgg cgtggttgta cttgaggtac gggttgtctc     2040

cgctgtcgag ctgccggtcg taggctttgt cgtgctcgag ggccgcggcg tctgcctcgt     2100

tgaccggctc tcccttgtcg agtccgttga agggtccgag gtacttgtac ccaggaagca     2160

caagacccct gctgtcgtcc ttatgccgct ctgcgggctt tggtggtggt gggccaggtt     2220

tgagcttcca ccactgtctt attccttcag agagagtgtc ctcgagccaa tctggaagat     2280

aaccatcggc agccatacct gatttaaatc atttattgtt caaagatgca gtcatccaaa     2340

tccacattga ccagatcgca ggcagtgcaa gcgtctggca cctttcccat gatatgatga     2400

atgtagcaca gtttctgata cgcctttttg acgacagaaa cgggttgaga ttctgacacg     2460

ggaaagcact ctaaacagtc tttctgtccg tgagtgaagc agatatttga attctgattc     2520

attctctcgc attgtctgca gggaaacagc atcagattca tgcccacgtg acgagaacat     2580

ttgttttggt acctgtctgc gtagttgatc gaagcttccg cgtctgacgt cgatggctgc     2640

gcaactgact cgcgcacccg tttgggctca cttatatctg cgtcactggg ggcgggtctt     2700

ttcttggctc cacccttttt gacgtagaat tcatgctcca cctcaaccac gtgatccttt     2760

gcccaccgga aaaagtcttt gacttcctgc ttggtgacct tcccaaagtc atgatccaga     2820

cggcgggtga gttcaaattt gaacatccgg tcttgcaacg gctgctggtg ttcgaaggtc     2880

gttgagttcc cgtcaatcac ggcgcacatg ttggtgttgg aggtgacgat cacgggagtc     2940

gggtctatct gggccgagga cttgcatttc tggtccacgc gcaccttgct tcctccgaga     3000

atggctttgg ccgactccac gaccttggcg gtcatcttcc cctcctccca ccagatcacc     3060

atcttgtcga cacagtcgtt gaagggaaag ttctcattgg tccagttgac gcagcaaggg     3120

cgaattcgtt taaacctgca ggactagtcc ctttagtgag gg                        3162


<210>  191
<211>  3164
<212>  DNA
<213>  Adeno-associated virus

<400>  191
gcgaattgaa tttagcggcc gcgaattcgc ccttcgcaga gaccaaagtt caactgaaac       60

gaattaaacg gtttattgat taacaagcaa ttacaaatta cgagtcaggt atctggtgcc      120

aatggggcga ggctctgaat acacgccatt agtgtccaca gtaaagtcca cattaacaga      180

cttgttgtag ttggaagtgt actgaatttc gggattccag cgtttgctgt tttccttctg      240

cagctcccac tcgatctcca cgctgacctg tcccgtggag tactgtgtga tgaaggaagc      300

aaactttgcc gcactgaagg tggtcgaagg attcgcaggt accggggtgt tcttgatgag      360

aatctgtgga ggagggtgtt taggtccgaa tccacccatg aggggagagg ggtgaaaatg      420

tccgtccgtg tgtggaatct ttgcccagat gggcccctga aggtacacat ctctgtcctg      480

ccagaccatg cctggaagaa cgccttgtgt gttgacatct gcggtagctg cttgtctgtt      540

gcctctctgg aggttggtag atacagaacc atactgctcc gtagccacgg gattggttgt      600

cctgatttcc tcttcgtctg taatcatgac cttttcaatg tccacatttg ttttctctga      660

gccttgcttc ccaaagatga gaaccccgct ctgaggaaaa aacttttctt cattgtcctt      720

gtggcttgcc atggccgggc ccggattcac cagagagtct ctgccattga ggtggtactt      780

ggtagctcca gtccacgagt attcactgtt gttgttatcc gcagatgtct ttgatactcg      840

ctgctggcgg taacagggtc caggaagcca gttcctagac tggtcccgaa tgtcactcgc      900

tccggcctga gaaaactgaa gccttgactg cgtggtggtt ccacttggag tgtttgttgt      960

gctcaagtaa tacaggtact ggtcgatgag aggattcatg agacggtcca gactctggct     1020

gtgagcgtag ctgctgtgga aaggaacgtc ctcaaaagtg tagctgaagg taaagttgtt     1080

tccggtacgc agcatctgag aaggaaagta ctccgggcag taaaatgaag agcgtcctac     1140

tgcctgactc ccgttgctca gggtgaggta tccatactgt ggcaccatga agacgtctgc     1200

tgggaacggc gggaggcatc cttgatgcgc cgagccgagg acgtacggga gctggtactc     1260

cgagtcagta aacacctgaa ccgtgctggt aaggttattg gcaatcgtcg tcgtaccgtc     1320

attctgcgtg acctctttga cttgaatgtt aaagagcttg aagttgagtc tcttgggtcg     1380

gaatccccag ttgttgttga tgagtctttg ccagtcacgt ggtgaaaagt ggcagtggaa     1440

tctgttgaag tcaaaatacc cccaaggggt gctgtagcca aagtagtgat tgtcgttcga     1500

ggctcctgat tggctggaaa tttgtctgta gaggtggttg ttgtaggtgg gcagggccca     1560

ggttcgggtg ctggtggtga tgactctgtc gcccatccat gtggaatcgc aatgccgatt     1620

tcccgaggaa ttacccactc cgtcggcgcc ctcgttattg tctgccattg gtgcgccact     1680

gcctgtagcc atcgtattag ttcccagacc agagggggct gctggtggct gtccgagagg     1740

ctgggggtca ggtactgagt ctgcgtctcc agtctgacca aaattcaatc tttttcttgc     1800

aggctgctgg cccgcctttc cggttcccga ggaggagtct ggctccacag gagagtgctc     1860

taccggcctc ttttttcccg gagccgtctt aacaggttcc ccaaccaggc ccagaggttc     1920

aagaaccctc tttttcgcct ggaagactgc tcgtccgagg ttgcccccaa aagacgtatc     1980

ttctttaagg cgctcctgaa actccgcgtc ggcgtggttg tacttgaggt acgggttgtc     2040

tccgctgtcg agctgccggt cgtaggcttt gtcgtgctcg agggccgcgg cgtctgcctc     2100

gttgaccggc tctcccttgt cgagtccgtt gaagggtccg aggtacttgt acccaggaag     2160

cacaagaccc ctgctgtcgt ccttatgccg ctctgcgggc tttggtggtg gtgggccagg     2220

tttgagcttc caccactgtc ttattccttc agagagagtg tcctcgagcc aatctggaag     2280

ataaccatcg gcagccatac ctgatttaaa tcatttattg ttcaaagatg cagtcatcca     2340

aatccacatt gaccagatcg caggcagtgc aagcgtctgg cacctttccc atgatatgat     2400

gaatgtagca cagtttctga tacgcctttt tgacgacaga aacgggttga gattctgaca     2460

cgggaaagca ctctaaacag tctttctgtc cgtgagtgaa gcagatattt gaattctgat     2520

tcattctctc gcattgtctg cagggaaaca gcatcagatt catgcccacg tgacgagaac     2580

atttgttttg gtacctgtct gcgtagttga tcgaagcttc cgcgtctgac gtcgatggct     2640

gcgcaactga ctcgcgcacc cgtttgggcc cacttatatc tgcgtcactg ggggcgggtc     2700

ttttcttggc tccacccttt ttgacgtaga attcatgctc cacctcaacc acgtgatcct     2760

ttgcccaccg gaaaaagtct ttgacttcct gcttggtgac cttcccaaag tcatgatcca     2820

gacggcgggt gagttcaaat ttgaacatcc ggtcttgcaa cggctgctgg tgttcgaagg     2880

tcgttgagtt cccgtcaatc acggcgcaca tgttggtgtt ggaggtgacg atcacgggag     2940

tcgggtctat ctgggccgag gacttgcatt tctggtccac gcgcaccttg cttcctccga     3000

gaatggcttt ggccgactcc acgaccttgg cggtcatctt cccctcctcc caccagatca     3060

ccatcttgtc gacacagtcg ttgaagggaa agttctcatt ggtccagttg acgcagcaag     3120

ggcgaattcg tttaaacctg caggactagt ccctttagtg aggg                      3164


<210>  192
<211>  3163
<212>  DNA
<213>  Adeno-associated virus

<400>  192
accctcacta aagggactag tcctgcaggt ttaaacgaat tcgcccttgc tgcgtcaact       60

ggagcaatga gaactttccc ttcaacgact gtgtcgacaa gatggtgatt tggtgggagg      120

aggggaagat gaccgccaag gtcgtggagt cggccaaagc cattctcgga ggaagcaagg      180

tgcgcgtgga ccagaaatgc aagtcctcgg cccagataga tccgactccc gtgatcgtca      240

cctccaacac caacatgtgc gccgtgattg acgggaactc aacgaccttc gaacaccagc      300

agccgttgca agaccggatg ttcaaatttg aactcacccg ccgtctggat catgactttg      360

ggaaggtcac caagcaggaa gtcaaagact ttttccggtg ggcaaaggat cacgtggttg      420

aggtggagca tggattctac gtcaaaaagg gtggagccaa gaaaagaccc gcccctagtg      480

acgcagatat aagtgagccc aaacgggtgc gcgagtcagt tgcgcagcca tcgacgtcgg      540

acgcggaagc ttcgatcaac tacgcggaca ggtaccaaaa caaatgttct cgtcacgtgg      600

gcatgaatct gatgctgttt ccctgcagac aatgcgagag aatgaatcaa aattcaaata      660

tctgcttcac tcacggacag aaagactgtt tagagtgctt tcccgtgtca gaatctcaac      720

ctgtttctgt cgtcaaaaag gcgtatcaga aactgcgcta cattcatcat atcatgggaa      780

aggtgccaga cgcttgcact gcctgcgatc tggtcaatgt ggatttggat gactgcatct      840

ctgaacaata aatgatttaa atcaggtatg gctgccgatg gttatcttcc agattggctc      900

gaggacactc tctctgaagg aataagacag tggtggaagc tcaaacctgg cccaccacca      960

ccaaagcccg cagagcggca taaggacgac agcaggggtc ttgtgcttcc tgggtacaag     1020

tacctcggac ccttcaacgg actcgacaag ggagagccgg tcaacgaggc agacgccgcg     1080

gccctcgagc acgacaaggc ctacgaccgg cagctcgaca gcggagacaa cccgtacctc     1140

aagtacaacc acgccgacgc ggagtttcag gagcgtctta aagaagatac gtcttttggg     1200

ggcaacctcg gacgagcagt cttccaggcg aaaaagaggg ttcttgaacc tctgggcctg     1260

gttgaggaac ctgttaagac ggctccggga aaaaagaggc cggtagagca ctctcctgcg     1320

gagccagact cctcctcggg aaccggaaaa gcgggccagc agcctgcaag aaaaagactg     1380

aatttcggtc agactggaga cgcagactcc gtacctgacc cccagcctct cggacagcca     1440

ccagcagccc ccacaagttt gggatctact acaatggcta caggcagtgg cgcaccaatg     1500

gcagacaata acgagggtgc cgatggagtg ggtaattcct caggaaattg gcattgcgat     1560

tcccaatggc tgggcgacag agtcatcacc accagcaccc gaacctgggc cctgcccacc     1620

tacaacaacc acctttacaa gcaaatctcc agccaatcag gagcctcaaa cgacaaccac     1680

tactttggct acagcacccc ctgggggtat tttgacttca acagattcca ctgccacttt     1740

tcaccacgtg actggcaaag actcatcaac aacaactggg gattccgacc caagagactc     1800

aacttcaagc tctttaacat tcaagtcaaa gaggtcacgc agaatgacgg tacgacgacg     1860

attgccaata accttaccag cacggttcag gtgtttactg actcggagta ccagctcccg     1920

tacgtcctcg gctcggcgca tcaaggatgc ctcccgccgt ttccagcgga cgtcttcatg     1980

gtcccacagt atggatacct caccctgaac aacgggagtc aggcggtagg acgctcttcc     2040

ttttactgcc tggagtgctt tccttctcag atgctgcgta ctggaaacaa ctttcagttc     2100

agctacactt ttgaagacgt gcctttccac agcagctacg ctcacagcca gagtttggat     2160

cggctgatga atcctctgat cgaccagtac ctgtattatc taaacagaac acaaacagct     2220

agtggaactc agcagtctcg gctactgttt agccaagctg gacccacaag catgtctctt     2280

caagctaaaa actggctgcc tggaccgtgt tatcgccagc agcgtttgtc aaagcaggca     2340

aacgacaaca acaacagcaa ctttccctgg actggagcta ccaagtacca cctcaatggc     2400

agagactctt tggtgaaccc gggcccggcc atggccagcc acaaggacga tgaagaaaag     2460

tttttcccca tgcatggaac cctaatattt ggtaaagaag gaacaaatgc taccaacgcg     2520

gaattggaaa atgtcatgat tacagatgaa gaggaaatca ggaccaccaa tcccgtggct     2580

acagagcagt acggatatgt gtcaaataat ttgcaaaact caaatactgc tgcaagtact     2640

gaaactgtga atcaccaagg agcattacct ggtatggtgt ggcaggatcg agacgtgtac     2700

ctgcagggac ccatttgggc caagattcct cacaccgatg gacactttca tccttctcca     2760

ctgatgggag gttttggact caaacacccg cctcctcaga ttatgatcaa aaacactccc     2820

gttccagcca atcctcccac aaacttcagt tctgccaagt ttgcttcctt catcacacag     2880

tattccacgg gacaggtcag cgtggagatc gagtgggagc tgcagaagga gaacagcaaa     2940

cgctggaatc ccgaaattca gtacacttcc aactacaaca aatctgttaa tgtggacttt     3000

actgtggaca ctaatggtgt gtattcagag cctcgcccca ttggcaccag atacctgact     3060

cgtaatctgt aattgcttgt taatcaataa accgtttaat tcgtttcagt tgaactttgg     3120

tctctgcgaa gggcgaattc gcggccgcta aattcaattc gcc                       3163


<210>  193
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  193

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Tyr Lys Gly Glu Pro 
    50                  55                  60                  


Val Asp Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Gly Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Arg Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Gly Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Leu Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Asp Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asp Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Pro Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  194
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  194
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactctac      180

aagggagagc cggtcgacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga gggttcttga acctctgggc ttggttgggg agcctgttaa aacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggca accagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggatct      600

actacaatgg ctacaggcag tggcgcacca gtggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggctctgccc acctacaata accacctcta caagcaaatc      780

tccagccaat caggagcctc aaacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgaccggca aagactcatc      900

aacaacaact ggggattccg accaaaaaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcggg gtaccagctc ccgtacgtcc tcggcttggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttcag ttcagctaca cctttgaaga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa gacacaatca aatagtggaa ctcttcagca gtctcggcta     1380

ctgtttagcc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctgtcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagccacaa agacgatgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggacaatgt catgattaca     1680

gatgaagaag aaatccgcac caccaatccc gtggctacgg agcagtacgg atatgtgtca     1740

aataatttgc aaaactcaaa tactggtcca actactggaa ctgtcaatca ccaaggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactta tgggaggttt tggactcaaa     1920

cacccacctc ctcagatcat gattaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggaca agtcagcgtg     2040

gagatcgagt gggagctgca gaaggaggac agcaaacgct ggaaccccga gatccagtac     2100

acttccaact ataacaaacc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  195
<211>  3161
<212>  DNA
<213>  Adeno-associated virus

<400>  195
cgaattgatt tagcggccgc gaattcgccc ttcgcagaga ccaaagttca actgaaacga       60

attaaacggt ttattgatta acaagcaatt acagattacg agtcaggtat ctggtgccaa      120

tggggcgagg ctctgaatac acaccattag tgtccacagt aaagtccaca ttaacagatt      180

tgttgtagtt ggaagtgtac tggatctcgg gattccagcg tttgctgttc tccttctgta      240

gctcccactc gatctccacg ctgacccgcc ccgtggaata ctgtgtgatg aaggaagcaa      300

actttgccgc actgaaggtg gtcgaaggat tcgcaggtac cggggtgttt ttgatgagaa      360

tctgtggagg agggtgttta agtccgaatc cgcccatgag gggagagggg tgaaaatgtc      420

cgtccgtgtg cggaatcttt gcccagatag gcccctgcag gtacacgtct ctgtcctgcc      480

agaccatgcc tggaagaacg ccttgtgtgt tgacatctgc agtagatgct tgtgtgttgc      540

cgctctggag gttggtagat acagaaccat actgctccgt ggccacggga ttggtggttc      600

tgatttcctc ttcgtctgta atcatgacct tttcaatgtc cacatttgtt ttctctgatc      660

cttgttttcc aaagatgaga accccgctct gaggaaaaaa cttttcttca tcgtccttgt      720

ggctggccat tgccgggccc ggattcacca gagagtctct gccattgagg tggtacttgg      780

tagctccaat ccacgagtat tcactgttgt tgttgtccgc agatgtcttt gatactcgct      840

gctggcggta acagggtcca ggaagccagt tcctagactg atcccgaatg tcactcgctc      900

cggcctgaga aaactgaagc ctggactgcg tggtggttcc gcttggagtg tttgttctgc      960

tcaagtaata caggtactgg tcgatgagag gattcatgag acggtccaaa ctctggctgt     1020

gagcgtagct gctgtggaaa ggaacatcct caaaggtgta gctgaaggta aagttgtttc     1080

cggtacgcag catctgagaa gggaagtact ccaggcagta aaatgaagag cgtcctactg     1140

cctgactccc gttgttcagg gtgaggtatc catactgtgg caccatgaag acgtctgctg     1200

ggaacggcgg gaggcatcct tgatgcgccg agccgaggac gtacgggagc tggtactccg     1260

agtcagtaaa cacctgaacc gtgctggtaa ggttattggc aatcgtcgtc gtaccatcat     1320

tctgcgtgac ctctctgact tgaatgttaa agagcttgaa gttgagtctc ttgggccgga     1380

atccccagtt gttgttgatg agtctttgcc agtcacgtgg tgaaaagtgg cagtggaatc     1440

tgttgaagtc aaaatacccc caaggggtgc tgtagccaaa gtagtggttg tcgttgctgg     1500

ctcctgattg gctggaaatc tgcttgtaca gatggttgtt gtaggtgggc agagcccagg     1560

ttcgggtgct ggtggtgatg actctgtcgc ccatccatgt ggaatcgcaa tgccaatttc     1620

ccgaggaatt acccactccg tcggcgccat cgttattgtc tgccattggt gcgccactgc     1680

ctgtagccat cgtattagtt cccagaccag agggggctgc tggtggctgt ccgagaggct     1740

gggggtcagg tacggagtct gcgtctccag tctgaccgaa attcaatctc tttcttgcag     1800

gctggttgcc cgcttttccg gttcccgagg aggagtctgg ctccacagga gagtgctcta     1860

ccggcctctt ttttcccgga gccgtcttaa caggctcctc aaccaggccc agaggttcaa     1920

gaaccctctt ttttgcctgg aagactgctc gtccgaggtt gcccccaaaa gacgtatctt     1980

ctttaaggcg ctcctgaaac tccgcgtcgg cgtggtcgta cttgaggtac gggttgtctc     2040

cgctgtcgag ctgccggtcg taggccttgt cgtgctcgag ggccgcggcg tctgcctcgt     2100

tgaccggctc tcccttgtcg agtccgttga agggtccgag gtacttgtac ccaggaagca     2160

caagacccct gctgtcgtcc ttatgccgct ctgcgggctt tggtggtggt gggccaggtt     2220

tgagcttcca ccactgtctt attccttcag agagagtgtc ctcgagccaa tctggaagat     2280

aaccatcggc agccatacct gatttaaatc atttattgtt cagagatgca gtcatccaaa     2340

tccacattga ccagatcgca ggcagtgcaa gcgtctggca cctttcccat gatatgatga     2400

atgtagcaaa gtttctgata cgcctttttg acgacagaaa cgggttgaga ttctgacacg     2460

ggaaagcact ctaaacagtc tttctgtccg tgagtgaagc agatatttga attctgattc     2520

attctctcgc attgtctgca gggaaacagc atcagattca tgcccacgtg acgagaacat     2580

ttgttttggt acctgtccgc gtagttgatc gaagcttccg cgtctgacgt cgatggctgc     2640

gcaactgact cgcgcgcccg tttgggctca cttatatctg cgtcactggg ggcgggtctt     2700

ttcttggctc cacccttttt gacgtagaat tcatgctcca cctcaaccac gtgatccttt     2760

gcccaccgga aaaagtcttt cacttcctgc ttggtgacct tcccaaagtc atgatccaga     2820

cggcgggtta gttcaaattt gaacatccgg tcttgcaacg gctgctggtg ttcgaaggtc     2880

gttgagttcc cgtcaatcac ggcgcacatg ttggtgttgg aggtggcgat cacgggagtc     2940

gggtctatct gggccgagga cttgcacttt tggtccacgc gcaccttgct tcctccgaga     3000

atggcttcgg ccgattccac gaccttggcg gtcatctttc cctcctccca ccagatcacc     3060

atcttgtcga cacagtcgtt gaagggaaag ttctcattgg tccagttgac gcagcaaggg     3120

cgaattcgtt taaacctgca ggaactagtc ccttagtgag g                         3161


<210>  196
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  196

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Tyr Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Gly Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Asp Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Tyr Val Ser Asn Asn Leu Gln Asp Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  197
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  197
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccgccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactctac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccgg cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga gggttcttga acctctgggc ttggttgagg agcctgttaa aacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggca accagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggatct      600

actacaatgg ctacaggcag tggcgcacca gtggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggctctgccc acctacaaca accacctcta caagcaaatc      780

tccagccaat caggagcctc aaacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg accaaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttcag ttcagctaca cctttgaaga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa gacacaatca aatagtggaa cccttcagca gtctcggcta     1380

ctgtttagcc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctgtcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagccacaa agacgatgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggacaatgt catgattaca     1680

gatgaagaag aaatccgcac caccaatccc gtggctacgg agcagtacgg atatgtgtca     1740

aataatttgc aagactcaaa tactggtcca actactggaa ctgtcaatca ccaaggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactta tgggaggttt tggactcaaa     1920

cacccacctc ctcagatcat gattaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggaca agtcagcgta     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaaccccga gatccagtac     2100

acttccaact ataacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  198
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  198

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Cys Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Pro Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Arg Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  199
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  199
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctgc aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagacag gccagcagcc cgcgaaaaag agactcaact ttgggcagac tggcgactca      540

gagtcagtgc ccgaccctca accaatcgga gaaccccccg caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctc cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcaacttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtctttac ggactcggaa taccagctcc cgtacgtcct cggctctgcg     1080

caccagggct gcccgcctcc gttcccggcg gacgtcttca tgattcctca gtacgggtac     1140

ctgactctga acaacggcag tcaggccgtg ggccgttcct ccttctactg cctggagtac     1200

tttccttctc aaatgcggag aacgggcaac aactttgagt tcagctacca gtttgaggac     1260

gtgccttttc acagcagcta cgcgcatagc caaagcctgg accggctgat gaaccccctc     1320

atcgaccagt acctgtacta cctgtctcgg actcagtcca cgggaggtac cgcaggaact     1380

cagcagttgc tattttctca ggccgggcct aataacatgt cggctcaggc caaaaactgg     1440

ctacccgggc cctgctaccg gcagcaacgc gtctccacga cactgtcgca aaataacaac     1500

agcaactttg cttggaccgg tgccaccaag tatcatctga atggcagaga ctctctggta     1560

aatcccggtg tcgctatggc aacgcacaag gacgacgaag agcgattttt tccatccagc     1620

ggagtcttga tgtttgggaa acagggagct ggaaaagaca acgtggacta tagcagcgtt     1680

atgctaacca gtgaggaaga aatcaaaacc accaacccag tggccacaga acagtacggc     1740

gtggtggccg ataacctgca acagcaaaac gccgctccta ttgtaggggc cgtcaacagt     1800

caaggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatc     1860

tgggccaaga ttcctcacac ggacggcaac tttcatcctt cgccgctgat gggaggcttt     1920

ggactgaaac acccgcctcc tcagatcctg attaagaata cacctgttcc cgcggatcct     1980

ccaactacct tcagtcaagc caagctggcg tcgttcatca cgcagtacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaagagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta taacaaatct gttaatgtgg actttactgt ggacactaat     2160

ggtgtgtatt cagagcctcg ccccattggc accagatacc tgactcgtaa tctgtaa        2217


<210>  200
<211>  3167
<212>  DNA
<213>  Adeno-associated virus

<400>  200
attgaattta gcggccgcga attcgccctt cgcagagacc aaagttcaac tgaaacgaat       60

taaacggttt attgattaac aagcaattac agattacgag tcaggtacct ggtgccaatg      120

gggcgaggct ctgaatacac accattagtg tccacagtaa agtccacatt aacagatttg      180

ttgtagttgg aagtgtactg aatctcggga ttccagcgtt tgctgttctc cttctgcagc      240

tcccactcga tctccacgct gacctgcccc gtggagtact gtgtaatgaa ggaagcaaac      300

tttgccgcac tgaaggtagt cgaaggattc gcaggtaccg gggtgttctt gatgagaatc      360

tgcgggggag ggtgtttaag tccgaatccg cccatgaggg gagaggggtg aaaatgtccg      420

tccgtgtgtg gaatctttgc ccagatgggc ccctgcaggt acacgtctct gtcctgccac      480

accatgcctg gaagaacgcc ttgtgtgttg acatctgagg tagctgcttg tgtgttgccg      540

ctctggaggt tggtagatac agaaccatac tgctccgtag ccacgggatt ggtggtcctg      600

atttcctctt cgtctgtaat catgaccttt tcaatgtcca cattagtttt tcccgagtct      660

tgttttccaa agatgagaac cccgctctga ggaaaaaact tttcttcatc gtccttgtgg      720

ctggccatgg ccgggcccgg attcaccaga gagtctcttc cattaaggtg gtacttggta      780

gctccagtcc acgagtattc actgttgttg ttatccgcag atgtctttga tactcgctgc      840

tggcggtaac agggtccagg aagccagttc ctagactggt cccgaatgtc acttgctccg      900

gcctgagaaa actgaagcct tgactgcgtg gtggttccgc ttggagtgtt tgttctgctc      960

aagtaataca ggtactggtc gatgagagga ttcatgagac ggtccaaact ctggctgtgg     1020

gcgtagctgc tgtggaaagg aacgtcctca aaggtgtagc tgaaggtaaa gttgtttccg     1080

gtacgcagca tctgagaagg aaagtactcc aggcagtaaa atgaagagcg tcctactgcc     1140

tgactcccgt tgttcagggt gaggtatcca tactgtggca ccatgaagac gtctgctggg     1200

aacggcggga ggcatccttg atgcgccgag ccgaggacgt acgggagctg gtactccgag     1260

tcagtaaaca cctgaaccgt gctggtaagg ttattggcaa tcgtcgtcgt accgtcattc     1320

tgcgtgacct ccttgacttg aatgttaaag agcttgaagt tgagtctttt gggccggaat     1380

ccccaattgt tgttgatgag tctttgccag tcacgtggcg aaaagtggca gtggaatctg     1440

ttgaagtcaa aataccccca aggggtgctg tagccaaagt agtggttgtc gtttgaggct     1500

cctgattggc tggaaatctg cttgtagagg tggttgttgt aggtgggcag agcccaggtg     1560

cgggtgctgg tggtgatgac tctgtcgccc atccatgtgg aatcgcaatg ccaatttccc     1620

gaggaattac ccactccgtc ggcgccctcg ttattgtctg ccattggtgc gccactgcct     1680

gtagccatcg tattagttcc cagaccagag ggggctgctg gtggctgtcc gagaggctgg     1740

gggtcaggta cggagtctgc gtctccagtc tgaccgaaat tcaatctctt tcttgcaggc     1800

tgctggcccg cttttccggt tcccgaggag gagtctggct ccgcaggaga gtgctctacc     1860

ggcctctttt ttcccggagc cgtcttaaca ggttcctcaa ccaggcccag aggttcaaga     1920

accctctttt tcgcctggaa gactgctcgt ccgaggttgc ccccaaaaga cgtatcttct     1980

ttaagacgct cctggaactc cgcgtcggcg tggttgtact tggggtacgg gttgtctccg     2040

ctgtcgagct gccggtcgta ggccttgtcg tgctcgaggg ccgcggcgtc tgcctcgttg     2100

accggctctc ccttgtcgag tccgttgaag ggtccaaggt acttgtaccc aggaagcaca     2160

agacccctgc tgtcgtcctt atgccgctct gcgggctttg gtggtggtgg gccaggtttg     2220

agcttccacc actgtcttat tccttcagag agagtgtcct cgagccaatc tggaagataa     2280

ccatcggcag ccatacctga tttaaatcat ttattgttca gagatgcagt catccaaatc     2340

cacattgacc agatcgcaag cagtgcaagc gtctggcacc tttcccatga tatgatgaat     2400

gtagcacagt ttctgatacg cctttttgac gacagaaacg ggttgagatt ctgacacggg     2460

aaagcactct aaacagtctt tctgtccgtg agtgaagcag atatttgaat tctgattcat     2520

tctctcgcat tgtctgcagg gaaacagcat cagattcatg cccacgtgac gagaacattt     2580

gttttggtac ctgtccgcgt agttgattga agcttccgcg tctgacgtcg atggctgcgc     2640

aactgactcg cgcgcccgtt tgggctcact tatatctgcg tcactggggg cgggtctttt     2700

tttggctcca ccctttttga cgtagaattc atgctctacc tcaaccacgt gatcctttgc     2760

ccaccggaaa aagtctttga cttcctgctt ggtgaccttc ccaaagtcat gatccagacg     2820

gcgggtgagt tcaaatttga acatccggtc ttgcaacggc tgctggtgtt cgaaggtcgt     2880

tgagttcccg tcaatcactg cgcacatgtt ggtgttggag gtgacaatca cgggagtcgg     2940

gtctatctgg gccgaggact tgcatttctg gtccacgcgc accttgcttc ctccgagaat     3000

ggctttggcc gactccacga ccttggcggt catcttcccc tcctcccacc agatcaccat     3060

cttgtcgacg caatcattga aaggaaagtt ctcattggtc cagttgacgc agccgtagaa     3120

agggcgaatt cgtttaaacc tgcaggacta gtccctttag tgagggt                   3167


<210>  201
<211>  3161
<212>  DNA
<213>  Adeno-associated virus

<400>  201
aattgaattt agcggccgcg aattcgccct tcgcagagac caaagttcaa ctgaaacgaa       60

ttaaacggtt tattgattaa caagcaatta cagattacga gtcaggtatc tggtgccaat      120

ggggcgaggc tctgaataca caccattagt gtccacagta aagtccacat taacagattt      180

gttgtagttg gaagtgtact gaatctcggg attccagcgt ttgctgttct ccttctgcag      240

ctcccactcg atctccacgc tgacctgccc cgtggagtac tgtgtaatga aggaagcaaa      300

ctttgccgca ctgaaggtag tcgaaggatt cgcaggtacc ggggtgttct tgatgagaat      360

ctgcggggga gggtgtttaa gtccgaatcc gcccatgagg ggagaggggt gaaaatgtcc      420

gtccgtgtgt ggaatctttg cccagatggg cccctgcagg tacacgtctc tgtcctgcca      480

caccatgcct ggaagaacgc cttgtgtgtt gacatctgag gtagctgctt gtgtgttgcc      540

gctctggagg ttggtagata cagaaccata ctgctccgta gccacgggat tggtggtcct      600

gatttcctct tcgtctgtaa tcatgacctt ttcaatgtcc acattagttt ttcccgagtc      660

ttgttttcca aagatgagaa ccccgctctg aggaaaaaac ttttcttcat cgtccttgtg      720

gctggccatg gccgggcccg gattcaccag agagtctctt ccattaaggt ggtacttggt      780

agctccagtc cacgagtatt cactgttgtt gttatccgca gatgtctttg atactcgctg      840

ctggcggtaa cagggtccag gaagccagtt cctagactgg tcccgaatgt cacttgctcc      900

ggcctgagaa aactgaagcc ttgactgcgt ggtggttccg cttggagtgt ttgttctgct      960

caagtaatac aggtactggt cgacgagagg attcatgaga cggtccaaac tctggctgtg     1020

ggcgtagctg ctgtggaaag gaacgtcctc aaaggtgtag ctgaaggtaa agttgtttcc     1080

ggtacgcagc atctgagaag gaaagtactc caggcagtaa aatgaagagc gtcctactgc     1140

ctgactcccg ttgttcaggg tgaggtatcc atactgtggc accatgaaga cgtctgctgg     1200

gaacggcggg aggcatcctt gatgcgccga gccgaggacg tacgggagct ggtactccga     1260

gtcagtaaac acctgaaccg tgctggtaag gttattggca atcgtcgtcg taccgtcatt     1320

ctgcgtgacc tccttgactt gaatgttaaa gagcttgaag ttgagtcttt tgggccggga     1380

tccccaattg ttgttgatga gtctttgcca gtcacgtggc gaaaagtggc agtggaatct     1440

gttgaagtca aaataccccc aaggggtgct gtagccaaag tagtggttgt cgtttgaggc     1500

tcctgattgg ctggaaatct gcctgtagag gtggttgttg taggtgggca gagcccaggt     1560

gcgggtgctg gtggtgatga ctctgtcgcc catccatgtg gaatcgcaat gccaatttcc     1620

cgaggaatta cccactccgt cggcgccctc gttattgtct gccattggtg cgccactgcc     1680

tgtagccatc gtattagttc ccagaccaga gggggctgct ggtggctgtc cgagaggctg     1740

ggggtcaggt acggagtctg cgtctccagt ctgaccgaaa ttcaatctcc ttcttgcagg     1800

ctgctggccc gcttttccgg ttcccgagga ggagtctggc tccgcaagag agtgctctac     1860

cggcctcttt tttcccggag ccgtcttaac aggttcctca accaggccca gaggttcaag     1920

aaccctcttt ttcgcctgga agactgctcg tccgaggttg cccccaaaag acgtatcttc     1980

tttaagacgc tcctggaact ccgcgtcggc gtggttgtac ttgaggtacg ggttgtctcc     2040

gccgtcgagc tgccggtcgt aggccttgtc gtgctcgagg gccgcggcgt ctgcctcgtt     2100

gaccggctct cccttgtcga gtccgttgaa gggtccaagg tacttgtacc caggaagcac     2160

aagacccctg ctgtcgtcct tatgccgctc tgcgggcttt ggtggtggtg ggccaggttt     2220

gagcttccac cactgtctta ttccttcaga gagagtgtcc tcgagccaat ctggaagata     2280

accatcggca gccatacctg atttaaatca tttattgttc agagatgcag tcatccaaat     2340

ccacattgac cagatcgcaa gcagtgcaag cgtctggcac ctttcccatg atatgatgaa     2400

tgtagcacag tttctgatac gcctttttga cgacagaaac gggttgagat tctgacacgg     2460

gaaagcactc taaacagtct ttctgtccgt gagtgaagca gatatttgaa ttctgattca     2520

ttctctcgca ttgtctgcag ggaaacagca tcagattcat gcccacgtga cgagaacatt     2580

tgttttggta cctgtccgcg tagttgattg aagcttccgc gtctgacgtc gatggctgcg     2640

caactgactc gcgcgcccgt ttgggctcac ttatatctgc gtcactgggg gcgggtcttt     2700

ttttggctcc accctttttg acgtagaatt catgctctac ctcaaccacg tgatcctttg     2760

cccaccggaa aaagtctttg acttcctgct tggtgacctt cccaaagtca tgatccagac     2820

ggcgggtgag ttcaaatttg aacatccggt cttgcaacgg ctgctggtgt tcgaaggtcg     2880

ttgagttccc gtcaatcact gcgcacatgt tggtgttgga ggtgacaatc acgggagtcg     2940

ggtctatctg ggccgaggac ttgcatttct ggtccacgcg caccttgctt cctccgagaa     3000

tggctttggc cgactccacg accttggcgg tcatcttccc ctcctcccac cagatcacca     3060

tcttgtcgac gcaatcattg aaaggaaagt tctcattggt ccagttgacg cagcaagggc     3120

gaattcgttt aaacctgcag gactagtccc tttagtgagg g                         3161


<210>  202
<211>  3172
<212>  DNA
<213>  Adeno-associated virus

<400>  202
gattgaattt agcggccgcg aattcgccct tgctgcgtca actggaccaa tgagaacttt       60

cccttcaacg attgcgtcga caagatggtg atctggtggg aggagggcaa gatgaccgcc      120

aaggtcgtgg agtccgccaa ggccattctg ggtggaagca aggtgcgcgt ggaccaaaag      180

tgcaagtcat cggcccagat cgaccccacg cccgtgatcg tcacctccaa caccaacatg      240

tgcgccgtga tcgacgggaa cagcaccacc ttcgagcacc agcagcccct gcaggaccgc      300

atgttcaagt tcgagctcac ccgccgtctg gagcacgact ttggcaaggt gaccaagcag      360

gaagtcaaag agttcttccg ctgggctcag gatcacgtga ctgaggtggc gcatgagttc      420

tacgtcagaa agggcggagc caccaaaaga cccgccccca gtgacgcgga tataagcgag      480

cccaagcggg cctgcccctc agttgcggag ccatcgacgt cagacgcgga agcaccggtg      540

gactttgcgg acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg      600

tttccctgca agacatgcga gagaatgaat cagaatttca acgtctgctt cacgcacggg      660

gtcagagact gctcagagtg cttccccggc gcgtcggaat ctcaacccgt cgtcagaaaa      720

aagacgtatc agaaactgtg cgcgattcat catctgctgg ggcgggcacc cgagattgcg      780

tgttcggcct gcgatctcgt caacgtggac ttggatgact gtgtttctga gcaataaatg      840

acttaaacca ggtatggctg ctgacggtta tcttccagat tggctcgagg acaacctctc      900

tgagggcatt cgcgagtggt gggacctgaa acctggagcc cccaagccca aggccaacca      960

gcagaagcag gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt     1020

caacggactc gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga     1080

caaggcctac gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc     1140

cgacgccgag tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg     1200

agcagtcttc caggccaaga agcgggttct cgaacctctc ggtctggttg aggaagctgc     1260

taagacggct cctggaaaga agagaccggt agaaccgtca cctcagcgtt cccccgactc     1320

ctccgcgggc atcggcaaga aaggccagca gcccgctaaa aagagactga actttggtca     1380

gactggcgac tcagagtcag tccccgaccc tcaaccaatc ggagaaccac cagcaggccc     1440

ctctggtctg ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa     1500

cgaaggcgcc gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct     1560

gggcgacaga gtcatcacca ccagcacccg aacctgggcc ctgcccacct acaacaacca     1620

cctctacaag caaatatcca atgggacatc gggaggaagc accaacgaca acacctactt     1680

cggctacagc accccctggg ggtattttga cttcaacaga ttccactgcc acttctcacc     1740

acgtgactgg cagcgactca tcaacaacaa ctggggattc cggccaaaaa gactcagctt     1800

caagctcttc aacatccagg tcaaggaggt cacgcagaat gaaggcaccg agaccatcgc     1860

caataacctt accagcacga ttcaggtatt tacggactcg gaataccagc tgccgtacgt     1920

cctcggctcc gcgcaccagg gctgcctgcc tccgttcccg gcggacgtct tcatgattcc     1980

ccagtacggc taccttacac tgaacaatgg aagtcaagcc gtaggccgtt cctccttcta     2040

ctgcctggaa tattttccat ctcaaatgct gcgaactgga aacaattttg aattcagcta     2100

caccttcgag gacgtgcctt tccacagcag ctgcgcacac agccagagct cggaccgact     2160

gatgaatcct ctcatcgacc agtacctgta ctacttatcc agaactcggt ccacaggagg     2220

aactcaaggt acccagcaat tgttattttc tcaagctggg cctgcaaaca tgtcggctca     2280

ggctaagaac tggctacctg gaccttgcta ccggcagcag cgagtctcta cgacactgtc     2340

gcaaaacaac aacagcaact ttgcttggac tggtgccacc aaatatcacc tgaacggaag     2400

agactctttg gtaaatcccg gtgtcgccat ggcaacccac aaggacgacg aggaacgctt     2460

cttcccgtcg agtggagtcc tgatgtttgg aaaacagggt gctggaagag acaatgtgga     2520

ctacagcagc gttatgctaa ccagcgaaga agaaattaaa accactaacc ctgtagccac     2580

agaacaatac ggtgtggtgg ctgacaactt gcagcaaacc aatacagggc ctattgtggg     2640

aaatgtcaac agccaaggag ccttacctgg catggtctgg cagaaccgag acgtgtacct     2700

gcagggtccc atctgggcca agattcctca cacggacggc aacttccacc cttcaccgct     2760

aatgggagga tttggactga agcacccacc tcctcagatc ctgatcaaga acacgccggt     2820

acctgcggat cctccaacaa cgttcagcca ggcgaaattg gcttccttca ttacgcagta     2880

cagcaccgga caggtcagcg tggaaatcga gtgggagctg cagaaggaga acagcaaacg     2940

ctggaaccca gagattcagt acacttcaaa ctactacaaa tctacaaatg tggactttgc     3000

tgtcaataca gagggaactt attctgagcc tcgccccatt ggtactcgtt acctcacccg     3060

taatctgtaa ttgctggtta atcaataaac cgtttgattc gtttcagttg aactttggtc     3120

tctgcgaagg gcgaattcgt ttaaacctgc aggactagtc cctttagtga gg             3172


<210>  203
<211>  3172
<212>  DNA
<213>  Adeno-associated virus

<400>  203
gattgaattt agcggccgcg aattcgccct tgctgcgtca actggaccaa tgagaacttt       60

cccttcaacg attgcgtcga caagatggtg atctggtggg aggagggcaa gatgaccgcc      120

aaggtcgtgg agtccgccaa ggccattctg ggtggaagca aggtgcgcgt ggaccaaaag      180

tgcaagtcat cggcccagat cgaccccacg cccgtgatcg tcacctccaa caccaacatg      240

tgcgccgtga tcggcgggaa cagcaccacc ttcgagcacc agcagcccct gcaggaccgc      300

atgttcaagt tcgagctcac ccgccgtctg gagcacgact ttggcaaggt gaccaagcag      360

gaagtcaaag agttcttccg ctgggctcag gatcacgtga ctgaggtggc gcatgagttc      420

tacgtcagaa agggcggagc caccaaaaga cccgccccca gtgacgcgga tataagcgag      480

cccaagcggg cctgcccctc agttgcggag ccatcgacgt cagacgcgga agcaccggtg      540

gactttgcgg acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg      600

tttccctgca agacatgcga gagaatgaat cagaatttca acgtctgctt cacgcacggg      660

gtcagagact gctcagagtg cctccccggc gcgtcagaat ctcaacccgt cgtcagaaaa      720

aagacgtatc agaaactgtg cgcgattcat catctgctgg ggcgggcacc cgagattgcg      780

tgttcggcct gcgatctcgt caacgtggac ttggatgact gtgtttctga gcaataaatg      840

acttaaacca ggtatggctg ctgacggtta tcttccagat tggctcgagg acaacctctc      900

tgagggcatt cgcgagtggt gggacctgaa acctggagcc cccaagccca aggccaacca      960

gcagaagcag gacgacggcc ggggtctggt gcttcttggc tacaagtacc tcggaccctt     1020

caacggactc gacaaggggg agcccgtcaa tgcggcggac gcagcggccc tcgagcacga     1080

caaggcctac gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc     1140

cgacgccgag tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg     1200

agcagtcttc caggccaaga agcgggttct cgaacctctc ggtctggttg aggaagctgc     1260

taagacggct cctggaaaga agagaccggt agaaccgtca cctcagcgtt cccccgactc     1320

ctccacgggc atcggcaaga aaggccagca gcccgctaaa aagagactga actttggtca     1380

gactggcgac tcagagtcag tccccgaccc tcaaccaatc ggagaaccac cagcaggccc     1440

ctctggtctg ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa     1500

cgaaggcgcc gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct     1560

gggcgacaga gtcatcacca ccagcacccg aacctgggcc ctgcccacct acaacaacca     1620

cctctacaag caaatatcca atgggacatc gggaggaagc accaacgaca acacctactt     1680

cggctacagc accccctggg ggtattttga cttcaacaga ttccactgcc acttctcacc     1740

acgtgactgg cagcgactca tcaacaacaa ctggggattc cggccaaaaa gactcagctt     1800

caagctcttc aacatccagg tcaaggaggt cacgcagaat gaaggcacca agaccatcgc     1860

caataacctt accagcacga ttcaggtatt tacggactcg gaataccagc tgccgtacgt     1920

cctcggctcc gcgcaccagg gctgcctgcc tccgttcccg gcggacgtct tcatgattcc     1980

ccagtacggc taccttacac tgaacaatgg aagtcaagcc gtaggccgtt cctccttcta     2040

ctgcctggaa tattttccat ctcaaatgct gcgaactgga aacaattttg aattcagcta     2100

caccttcgag gacgtgcctt tccacagcgg ctacgcacac agccagagct tggaccgact     2160

gatgaatcct ctcatcgacc agtacctgta ctacttatcc agaactcagt ccacaggagg     2220

aactcaaggt acccagcaat tgttattttc tcaagctggg cctgcaaaca tgtcggctca     2280

ggctaagaac tggctacctg gaccttgcta ccggcagcag cgagtctcta cgacactgtc     2340

gcaaaacaac aacagcaact ttgcttggac tggtgccacc aaatatcacc tgaacggaag     2400

agactctttg gtaaatcccg gtgtcgccat ggcaacccac aaggacgacg aggaacgctt     2460

cttcccgtcg agtggagtcc tgatgtttgg aaaacagggt gctggaagag acaatgtgga     2520

ctacagcagc gttatgctaa ccagcgaaga agaaattaaa accactaacc ctgtagccac     2580

agaacaatac ggtgtggtgg ctgacaactt gcagcaaacc aatacagggc ctattgtggg     2640

aaatgtcaac agccaaggag ccttacctgg catggtctgg cagaaccgag acgtgtacct     2700

gcagggtccc atctgggcca agattcctca cacggacggc aacttccacc cttcaccgct     2760

aatgggagga tttggactga agcacccacc tcctcagatc ctgatcaaga acacgccggt     2820

acctgcggat cctccaacga cgttcagcca ggcgaaattg gcttccttca ttacgcagta     2880

cagcaccgga caggtcagcg tggaaatcga gtgggagctg cagaaggaga acagcaaacg     2940

ctggaaccca gagattcagt acacttcaaa ctactacaaa tctacaaatg tggactttgc     3000

tgtcaataca gagggaactt attctgagcc tcgccccatt ggtactcgtt acctcacccg     3060

taatctgtaa ttgctggtta atcaataaac cgtttgattc gtttcagttg aactttggtc     3120

tctgcgaagg gcgaattcgt ttaaacctgc aggactagtc cctttagtga gg             3172


<210>  204
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  204
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg aaagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg agcctgttaa aacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc gagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggatct      600

actacaatgg cttcaggcag tggcgcacca gtggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tccagccaat caggagcctc aaacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacagct ggggattccg acccaaaaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caagtgttta ccgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttt atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttcag ttcagctaca cctttgaaga cgttcccttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctgc tgaatcctct gatcgaccag     1320

tacctatatt atctgaacaa gacacaatca aatagtggaa ctcttcagca gtctcggcta     1380

ctgtttagcc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctgtcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagccacaa agacgatgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggacaatgt catgattaca     1680

gatgaagaag aaatccgcac caccaatccc gtggctacgg agcagtacgg atatgtgtca     1740

aataatttgc aaaactcaaa tactggtcca actactggaa ctgtcaatca ccaaggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca cggacgggca ctttcatcct tctccactaa tgggaggttt tgggctcaaa     1920

cacccgcctc ctcagatcat gatcaaaaac actcccgttc cagccaatcc tcctacaaac     1980

ttcagttctt ccaagtttgc ttctttcatc acacagtatt ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtat     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ccgactcgta atctgtaa                  2208


<210>  205
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  205

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Glu Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Ser Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Leu Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Asp Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ser Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Pro Thr Arg Asn Leu 
                725                 730                 735 


<210>  206
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  206
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga ggattcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggagaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaattttg gccagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg cttcaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggtattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgcacctg ggccctgccc acctacaaca accatctgta caagcaaatc      780

tccagccagt ctggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttctccccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggca gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gtaccggaaa caactttacc ttcagctaca cctttgaaga cgttcctttc     1260

catagcagct acgctcacag ccaaagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgat gtccaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctagaaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa cagtgattac     1500

tcgtggactg gagctaccaa gtaccacctc aatggaagag actctctggt gaatccgggc     1560

ccagctatgg ccagccacaa ggacgatgaa gaaaaatatt ttcctcagag cggggttctc     1620

atctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt tatgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctcg tgggcggatt cggacttaaa     1920

caccctcctc cacaaattct catcaagaac accccggtac ctgcgaatcc ttcgaccact     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  207
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  207

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Glu Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp Tyr Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Val Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  208
<211>  2209
<212>  DNA
<213>  Adeno-associated virus

<400>  208
atggctgccg atggttatcc tccagattgg ctcgaggaca ctctctctga agggataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcagagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcggcctgc aagaaaaaga ttaaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acatacaaca accacctcta caagcaaatc      780

tccagccaat caggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaaaaga ctcaacttca agctctttaa tattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tgggctcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttcag ttcagctaca cttttgaaga cgtgcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa gacacaaaca aatagtggaa ctcttcagca gtctcggcta     1380

ctgtttagcc aagctggacc aaccaacatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctgtcaaaa caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cagctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagtcacaa ggatgacgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgccaac gacgcggatt tggaaaatgt catgattaca     1680

gatgaagaag aaatcagggc caccaatccc gtggctacgg agcagtacgg gactgtgtca     1740

aataatttgc aaaactcaaa cactggtcca actactggaa ctgtcaatcg ccaaggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactga tgggaggttt tggactcaaa     1920

cacccgcctc ctcagatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaat                 2209


<210>  209
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  209

Met Ala Ala Asp Gly Tyr Pro Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Arg Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Thr Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Asn Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Ala Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Thr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn Arg Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  210
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  210
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aggtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgtcga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga ggattcttga acctctgggc ctggttgagg aacctgttaa ggcggctccg      420

ggagaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg cttcaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgcacctg ggccctgccc acctacaaca accatctgta caagcaaatc      780

tccagccagt ctggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

cattttgact tcaacagatt ccactgccac ttctccccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggca gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gtaccggaaa caactttacc ttcagctaca cctttgaaga cgttcctttc     1260

catagcagct acgctcacag ccaaagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgat gtccaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctagaaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa cagtgattac     1500

tcgtggactg gagctaccaa gtaccacctc aatggaagag actctctggt gaatccgggc     1560

ccagctatgg ccagccacaa ggacgatgaa gaaaaatatt ttcctcagag cggggttctc     1620

atctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt tatgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccccca tgggcggatt cggacttaaa     1920

caccctcctc cacaaattct catcaagaac accccggtac ctgcgaatcc ttcgaccact     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg cgccagatac ctgactcgta atctgtaa                  2208


<210>  211
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  211

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Arg Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Val 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Ala Ala Pro Gly Glu Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly His Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Pro Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Ala Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  212
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  212
atggctgccg atggttatct tccagattgg ctcgaggaca ccctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga taacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagagga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga ggattcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccggcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg cttcaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgcacctg ggccctgccc acctacaaca accatctgta caagcaaatc      780

tccagccagt ctggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttctccccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggca gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gtaccggaaa caactttacc ttcagctaca cctttgaaga cgttcctttc     1260

catagcagct acgctcacag ccaaagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgat gtccaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctagaaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa cagtgattac     1500

tcgtggactg gagctaccaa gtaccacctc aatggaagag actctctggt gaatccgggc     1560

ccagctatgg ccagccacaa ggacgatgaa gaaaaatatt ttcctcagag cggggttctc     1620

atctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt tatgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt cggacttaaa     1920

caccctcctc cacaaattct catcaagaac accccggtac ctgcgaatcc ttcgaccact     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  213
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  213

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Arg Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  214
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  214
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaaggaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga ggattcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg cttcaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcgg cagagtcatc      720

accaccagca cccgcacctg ggccctgccc acctacaaca accatctgta caagcaaatc      780

tccagccagt ctggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttctccccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggca gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagacgcttc gtaccggaaa caactttacc ttcagctaca cctttgaaga cgttcctttc     1260

catagcagct acgctcacag ccaaagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgat gtccaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctagaaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa cagtgattac     1500

tcgtggactg gagctaccaa gtaccacctc aatggaagag actctctggt gaatccgggc     1560

ccagctatgg ccagccacaa ggacgatgaa gaaaaatatt ttcctcagag cggggttctc     1620

atctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt tatgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt cggacttaaa     1920

caccctcctc cacaaattct catcaagaac accccggtac ctgcgaatcc ttcgaccact     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  215
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  215

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Gly Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Gly Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Thr Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  216
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  216
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga ggattcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg cttcaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgcacctg ggccctgccc acctgcaaca accatctgta caagcaaatc      780

tccagccagt ctggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttctccccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggca gtcaggcggt aggacgctct tccttttact gcctggagta ttttccttct     1200

cagatgcttc gtaccggaaa caactttacc ttcagctaca cctttgaaga cgttcctttc     1260

catagcagct acgctcacag ccaaagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgat gtccaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctagaaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa cagtgattac     1500

tcgtggactg gagctaccaa gtaccacctc aatggaagag actctctggt gaatccgggc     1560

ccagctatgg ccagccacaa ggacgatgaa gaaaaatatt ttcctcagag cggggttctc     1620

atctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt tatgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

acctacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc gggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt tggacttaaa     1920

caccctcctc cacaaattct catcaagaac accccggtac ctgcgaatcc ttcgaccact     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  217
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  217

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Cys Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Tyr Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Arg Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  218
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  218
atggctgccg atggttatct tccagattgg ctcgaggaca ccctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga taacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagagga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga ggattcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccggcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg cttcaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgcacctg ggccctgccc acctacaaca accatctgta caagcaaatc      780

tccagccagt ctggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttctccccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggca gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gtaccggaaa caactttacc ttcagctaca cctttgaaga cgttcctttc     1260

catagcagct acgctcacag ccaaagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgat gtccaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctagaaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa cagtgattac     1500

tcgtggactg gagctaccaa gtaccacctc aatggaagag actctctggt gaatccgggc     1560

ccagctatgg ccagccacaa ggacgatgaa gaaaaatatt ttcctcagag cggggttctc     1620

atctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt tatgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt cggacttaaa     1920

caccctcctc cacaaattct catcaagaac accccggtac ctgcgaatcc ttcgaccact     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  219
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  219

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Arg Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  220
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  220
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

ggcagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctca acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcaaaaaaga gggttcttga acctctgggc ctggttgagg agcctgttaa aacggctccg      420

ggaaaaaaga gaccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accacaagca ctcgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tccagccaat caggagcctc aaacgacaac cactattttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct cccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttcag ttcagctaca cttttgaaga cgtgcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa gacacaaaca aatagtggaa ctcttcagca gtctcggcta     1380

ctgtttagcc aagctggacc caccaacatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctgtcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cagctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagtcacaa ggatgacgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgccaac gacgcggatt tggaaaatgt catgattaca     1680

gatgaagaag aaatcaggac caccaatccc gtggctacgg agcagtacgg gactgtgtca     1740

aataatttgc aaaactcaaa cactggtcca actactggaa ctgtcaatca ccaaggagcg     1800

ttacctggta tggtgtggca ggatcgagat gtgtaccttc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactga tgggaggttt tggactcaaa     1920

cacccgcctc ctcagattat gatcaaaaac actcccgttc cagccaatcc tcctacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacaataa tggcgtgtac     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  221
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  221

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Gly Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asn Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Pro Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Thr Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Asn Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Thr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Asn Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  222
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  222
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga ggattcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg cttcaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgcacctg ggccctgccc acctacaaca accatctgta caagcaaatc      780

tccagccagt ctggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttctccccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggca gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gtaccggaaa caactttacc ttcagctaca cctttgaaga cgttcctttc     1260

catagcagct acgctcacag ccaaagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgat gtccaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctagaaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa cagtgattac     1500

tcgtggactg gagctaccaa gtaccacctc aatggaagag actctctggt gaatccgggc     1560

ccagctatgg ccagccacaa ggacgatgaa gaaaaatatt ttcctcagag cggggttctc     1620

atctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt tatgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt cggacttaaa     1920

caccctcctc cacaaattct catcaagaac accccggtac ctgcgaatcc ttcgaccact     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  223
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  223

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  224
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  224
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga ggattcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg cttcaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgcacctg ggccctgccc acctacaaca accatctgta caagcaaatc      780

tccagccagt ctggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tatttcgact tcaacagatt ccactgccac ttctccccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcggg gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgccttccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggca gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gtaccggaaa caactttacc ttcagctaca cctttgaaga cgttcctttc     1260

catagcagct acgctcacgg ccaaagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgat gtccaggctt     1380

cagttttctc aggccggagc aagtgacgtt cgggaccagt ctagaaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa cagtgattac     1500

tcgtggactg gagctaccaa gtaccacctc aatggaagag actctctggt gaatccgggc     1560

ccagctatgg ccagccacaa ggacgatgaa gaaaaatatt ttcctcagag cggggttctc     1620

gtctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt tatgattaca     1680

gacgaagagg aaatcaggac caccaatccc gcggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt cggacttaaa     1920

caccctcctc cacaaattct catcaagaac accccggtac ctgcgaatcc ttcgaccact     1980

ttcagtgcgg caaagtttgt ttccttcatc acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  225
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  225

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Gly Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Gly Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Val Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Val Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Ala Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Val Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  226
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  226
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga aactcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcaaaaaaga gggttctgga acctctgagc ctggttgagg agcctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctccc gcagagccag attcctcctc cggaactgga      480

aagtcgggca accagcctgc aagaaagaga ttgaatttcg gtcagactgg agactcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accatctgta caagcaaata      780

tccagccagt ctggagccag caacgacaat cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctagagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgca gtccaggctt     1380

cagttttctc aggccggagc gagtgacatt caggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gtcagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg ccagccacaa agacgatgaa gaaaagtttt ttcctcagag cggggttctt     1620

atctttggga agcaaggctc agagaaaaca aatgtggata ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtcgggca agacagagac gtgtacctgc aggggcctac ttgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt tggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatt acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga gatccagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  227
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  227

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Ser Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ser Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Gln Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Gly Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Thr Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  228
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  228
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcagagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcaaaaaaga gggttctgga acctctgggc ctggttgagg agcctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcagagccag attcctcctc cggaactgga      480

aagtcgggca accagcctgc aagaaagaga ttgaatttcg gtcagactgg agactcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accatctgta caagcaaata      780

tccagccagt ctggagccag caacgacaat cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctagggta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgca gtccaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gtcagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg ccagccacaa agacgatgaa gaaaagtttt ttcctcagag cggggttctt     1620

atctttggga agcaaggccc agagaaaaca aatgtggata ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca agacagagac gtgtacctgc aggggcctat ttgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt tggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatt acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga gatccagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  229
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  229

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ser Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Gly Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Pro Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  230
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  230

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ser Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Pro Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  231
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  231

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ser Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Pro Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  232
<211>  2211
<212>  DNA
<213>  Adeno-associated virus

<400>  232
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcagagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgcgg cctggtttga ggaaacctgt taagacggct      420

ccgggaaaaa agaggccggt agagcactct cctgtggagc cagactcctc ctcgggaacc      480

ggaaaagcgg gccagcagcc tgcaagaaaa agattaaatt ttggtcagac tggagacgca      540

gactccgtac ctgaccccca gcctctcgga cagccaccag cagccccctc tggtctggga      600

tctactacaa tggctacagg cagtggcgca ccaatggcag acaataacga gggtgccgat      660

ggagtgggta attcctcagg aaattggcat tgcgattccc aatggctgga cgacagagtc      720

atcgccacca gcacccgaac ctgggccctg cccacataca acaaccacct ctacaagcaa      780

atctccagcc aatcaggagc ctgcaacgac aaccactact ttggctacag caccccctgg      840

gggtattttg acttcaacag attccactgc cacttttcac cacgtgactg gcaaagactc      900

atcaacagca actggggatt ccggcccaaa agactcaact tcaagctctt taatattcaa      960

gtcaaagagg tcacgcagaa tgacggtacg acgacgattg ccaataacct taccagcacg     1020

gttcaggtgt ttactgactc ggagtaccag ctcccgtacg tcccgggctc ggcgcatcaa     1080

ggatgcctcc cgccgtttcc agcggacgtc ttcatggtcc cacagtatgg atacctcacc     1140

ctgaacaacg ggagtcaggc ggtaggacgc tcttcctttt actgcctgga gtactttcct     1200

tctcagatgc tgcgtactgg aaacaacttt cagttcagct acacttttga agacgtgcct     1260

ttccacagca gctacgctca ctgccagagt ctggatcggc tgatgaatcc tctgatcgac     1320

cagtacctgt attatctgaa caagacacaa acaaatagtg gaactcttca gcagtctcgg     1380

ctactgttta gccaagctgg accaaccaac atgtctcttc aagctaaaaa ctggctgcct     1440

ggaccttgct acagacagca gcgtctgtca aaacaggcaa acgacaataa caactgcaac     1500

tttccctgga ctgcagctac aaagtatcat ctaaatggcc gggactcgtt ggttaatcca     1560

ggaccagcta tggccagtca caaggatgac gaagaaaagt ttttccccat gcatggaacc     1620

ctgatatttg gtaaacaagg aacaaatgcc aacgacgcgg atttggaaaa tgtcatgatt     1680

acagatgaag aagaaatcag gcccaccaat cccgtggcta cggagcagta cgggactgtg     1740

tcaaataatt tgcaaaactc aaacactggt ccaactacag gaactgtcaa tcaccaagga     1800

gcgttacctg gtatggtgtg gcaggatcga gacgtgtacc tgcagggacc catttgggcc     1860

aagattcctc acaccgatgg acactttcat ccttctccac tgatgggagg ttttggactc     1920

aaacacccgc ctcctcagat catgatcaaa agcactcccg ttccagccaa tcctcccaca     1980

aacttcagtt ctgccaagtt tgcttcttcc atcacacagt attccacggg acaggtcagc     2040

gtggagatcg agtgggagct gcagaaggag aacagcaaac gctggaatcc cgaaattcag     2100

tacacttcca actacaacaa gtctgttaat gtggacttta ctgtggacac taatggtgtg     2160

tattcagagc ctcgccccat tggcaccaga tacctgactc gtaatctgta a              2211


<210>  233
<211>  736
<212>  PRT
<213>  Adeno-associated virus

<400>  233

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Arg Pro Gly Leu Arg Lys Pro Val Lys Thr Ala Pro Gly Lys Lys 
    130                 135                 140                 


Arg Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr 
145                 150                 155                 160 


Gly Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Asp Asp Arg Val 
225                 230                 235                 240 


Ile Ala Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Cys Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Ser Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Pro Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Cys Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys 
        435                 440                 445             


Thr Gln Thr Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Thr Asn Met Ser Leu Gln Ala Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Cys Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr 
            580                 585                 590         


Thr Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Ser Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Ser Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  234
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  234
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagagga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcaaaaaaga gggttctgga acctctgggc ctggttgagg agcctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcagagccag attcctcctc cggaactgga      480

aagtcgggca accagcctgc aagaaagaga ttgaatttcg gtcagactgg agactcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accatctgta caagcaaata      780

tccagccagt ctggagccag caacgacaat cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctagagta ctttccttct     1200

cagatgctgc gtaccggaaa cagctttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgca gtccaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gtcagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg ccagccacaa agacgatgaa gaaaagttct ttcctcagag cggggttctt     1620

atctttggga agcaaggctc agagaaaaca aatgtggata ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca agacagagac gtgtacctgc aggggcctat ttgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt tggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatt acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga gatccagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  235
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  235

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ser Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Ser Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  236
<211>  2211
<212>  DNA
<213>  Adeno-associated virus

<400>  236
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     1140

acgcttaatg atggaagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     1320

gaccaatact tgtactatct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gtgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtgc ccaagcacag gcgcagaccg gctgggttca aaaccaagga     1800

atacttccgg gtatggtttg gcaggacaga gatgtgtacc tgcaaggacc catttgggcc     1860

aaaattcctc acacggacgg caactttcac ccttctccgc tgatgggagg gtttggaatg     1920

aagcacccgc ctcctcagat cctcatcaaa aacacacctg tacctgcgga tcctccaacg     1980

gccttcaaca aggacaagct gaactctttc atcacccagt attctactgg ccaagtcagc     2040

gtggagatcg agtgggagct gcagaaggaa aacagcaagc gctggaaccc ggagatccag     2100

tacacttcca actattacaa gtctaataat gttgaatttg ctgttaatac tgaaggtgta     2160

tatagtgaac cccgccccat tggcaccaga tacctgactc gtaatctgta a              2211


<210>  237
<211>  736
<212>  PRT
<213>  Adeno-associated virus

<400>  237

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ser Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Gly Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Ser Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  238
<211>  2211
<212>  DNA
<213>  Adeno-associated virus

<400>  238
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtt cacagcccgc taaaaagaaa ctcaatttcg gtcagactgg cgacacagag      540

tcagtccccg accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     1140

acgcttaatg atgggagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     1320

gaccaatact tgtactatct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gcgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtgc ccaagcacag gcgcagaccg gctgggttca aaaccaagga     1800

atacttccgg gtatggtttg gcaggacaga gatgtgtacc tgcaaggacc catttgggcc     1860

aaaattcctc acacggacgg caactttcac ccttctccgc taatgggagg gtttggaatg     1920

aagcacccgc ctcctcagat cctcatcaaa aacacacctg tacctgcgga tcctccaacg     1980

gctttcaata aggacaagct gaactctttc atcacccagt attctactgg ccaagtcagc     2040

gtggagattg agtgggagct gcagaaggaa aacagcaagc gctggaaccc ggagatccag     2100

tacacttcca actattacaa gtctaataat gttgaatttg ctgttaatac tgaaggtgta     2160

tatagtgaac cccgccccat tggcaccaga tacctgactc gtaatctgta a              2211


<210>  239
<211>  736
<212>  PRT
<213>  Adeno-associated virus

<400>  239

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ser Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  240
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  240
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagcggtgga agctcaaacc tggcccacca ccaccagagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggtacttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cggcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg ggccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  241
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  241

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Arg Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Glu Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Gly Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Gly Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  242
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  242
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagcggtgga agctcaaacc tggcccacca ccaccagagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtccttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggtacttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacgaga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg ggccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  243
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  243

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Arg Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Glu Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Glu Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Gly Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  244
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  244
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagcggtgga agctcaaacc tggcccacca ccaccagagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggtacttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtaccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg ggccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  245
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  245

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Arg Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Glu Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Gly Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  246
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  246
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagcggtgga agctcaaacc tggcccacca ccaccagagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggtactcga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagc aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg ggccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc cgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  247
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  247

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Arg Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Glu Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Ala Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Gly Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  248
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  248

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  249
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  249
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattttgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccgtcgagt     1620

ggagtcctga tgttcggaaa acagggtgct ggaagagaca atgtggacta cagcagcgtt     1680

atgctaacca gcgaagaaga aattaaaacc actaaccccg tagccacaga acaatacggt     1740

gtggtggctg acaacttgca gcaaaccaat acagggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccaccctt caccgctaat gggaggattt     1920

ggactgaagc acccacctcc tcagatcctg atcaagaaca cgccggtacc tgcggatcct     1980

ccaacaacgt tcagccaggc gaaattggct tccttcatta cgcagtacag caccggacag     2040

gtcagcgtgg aaatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaacccagag     2100

attcagtaca cttcaaacta ctacaaatct acaaatgtgg actttgctgt caatacagag     2160

ggaacttatt ctgagcctcg ccccattggt actcgttacc tcacccgtaa tctgtaa        2217


<210>  250
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  250

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Cys His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  251
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  251

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Arg 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Leu Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Ala Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Pro Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Arg Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Thr Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Ala Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Ala Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  252
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  252
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcggac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtt      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt atcttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcgcc     1020

agcaccatcc aggtgtttac ggactcggaa taccagccgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctcg ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ctgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatcg cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgcgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210>  253
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  253
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcagagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg agcctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaaaaga ttaaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acatacaaca accacctcta caagcaaatc      780

tccagccaat caggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcgtc      900

aacaacaacc ggggattccg gcccaaaaga ctcaacttca agctctttaa tattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tgggctcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttcag ttcagctaca cttttgaaga cgtgcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa gacacaaaca aatagtggaa ctcttcagca gtctcggcta     1380

ctgtttagcc aagctggacc aaccaacatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctgtcaaaa caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cagctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagtcacaa ggatgacgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgccaac gacgcggatt tggaaaatgt catgattaca     1680

gatgaagaag aaatcagggc caccaatccc gtggctacgg agcagtacgg gactgtgtca     1740

aataatttgc aaaactcaaa cactggtcca actactggaa ctgtcaatca ccaaggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactga tgggaggttt tggactcaaa     1920

cacccgcctc ctcagatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  254
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  254

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Val Asn Asn Asn Arg 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Thr Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Asn Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Ala Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Thr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  255
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  255

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Ser Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Ser Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  256
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  256
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgagct ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattctgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccgtcgagt     1620

ggagtcctga tgtttggaaa acagggtgct ggaagagaca atgtggacta cagcagcgtt     1680

atgctaacca gcgaagaaga aattaaaacc actaaccctg tagccacaga acaatacggt     1740

gtggtggctg acaacttgca gcaaaccaat acagggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccaccctt caccgctaat gggaggattt     1920

ggactgaagc acccacctcc tcagatcctg atcaagaaca cgccggtacc tgcggatcct     1980

ccaacaacgt tcagccaggc gaaattggct tccttcatta cgcagtacag caccggacag     2040

gtcagcgtgg aaatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaacccagag     2100

attcagtaca cttcaaacta ctacaaatct acaaatgtgg actttgctgt caatacagag     2160

ggaacttatt ctgagcctcg ccccattggt actcgttacc tcacccgtaa tctgtaa        2217


<210>  257
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  257

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Pro Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Pro Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Val Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  258
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  258
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tacaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ccggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgccacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccgtcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattttgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccgtcgagt     1620

ggagtcctga tgtttggaaa acagggtgct ggaagagaca atgtggacta cagcagcgtt     1680

atgctaacca gcgaagaaga aattaaaacc actaaccctg tagccacaga acaatacggt     1740

gtggtggctg acaacttgca gcaaaccaat acagggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccaccctt caccgctaat gggaggattt     1920

ggactgaagc acccacctcc tcagatcctg atcaagaaca cgccggtacc tgcggatcct     1980

ccaacaacgt tcagccaggc gaaattggct tccttcatta cgcagtacag caccggacag     2040

gtcagcgtgg aaatcgagtg ggagctgcag aaggagaaca gcaaacgttg gaacccagag     2100

attcagtaca cttcaaacta ctacaaatct acaaatgtgg actttgctgt caatacagag     2160

ggaacttatt ctgagcctcg ccccattggt actcgttacc tcacccgtaa tctgtaa        2217


<210>  259
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  259

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Ser Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Leu 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  260
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  260
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattttgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aagcaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccgtcgagt     1620

ggagtcctga tgtttggaaa acagggtgct ggaagagaca atgtggacta cagcagcgtt     1680

atgctaacca gcgaagaaga aattaaaacc actaaccctg tagccacaga acaatacggt     1740

gtggtggctg acaacttgca gcaaaccaat acagggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccaccctt caccgctaat gggaggactt     1920

ggactgaagc acccacctcc tcagatcctg atcaagaaca cgccggtacc tgcggatcct     1980

ccaacaacgt tcagccaggc gaaattggct tccttcatta cgcagtacag caccggacag     2040

gtcagcgtgg aaatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaacccagag     2100

attcagtaca cttcaaacta ctacaaatct acaaatgtgg actttgctgt caatacagag     2160

ggaacttatt ctgagcctcg ccccattggt actcgttacc tcacccgtaa tctgtaa        2217


<210>  261
<211>  737
<212>  PRT
<213>  Adeno-associated virus

<400>  261

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Pro Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Pro Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn 
            260                 265                 270         


His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Leu His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Val Gln Tyr Leu Tyr Tyr Leu Asn 
        435                 440                 445             


Arg Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe 
    450                 455                 460                 


Ser Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu 
            500                 505                 510         


Asn Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe 
    530                 535                 540                 


Gly Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Arg Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro 
            580                 585                 590         


Ala Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Ala Lys Ser Ala Ser Val Asp Phe Thr Val Asp Asn Asn Gly 
705                 710                 715                 720 


Leu Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 735     


Leu 
    


<210>  262
<211>  737
<212>  PRT
<213>  Adeno-associated virus

<400>  262

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Pro Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn 
            260                 265                 270         


His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Leu His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn 
        435                 440                 445             


Arg Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe 
    450                 455                 460                 


Ser Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu 
            500                 505                 510         


Asn Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe 
    530                 535                 540                 


Gly Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Arg Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro 
            580                 585                 590         


Ala Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Ala Lys Ser Ala Ser Val Asp Phe Thr Val Asp Asn Asn Gly 
705                 710                 715                 720 


Leu Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 735     


Leu 
    


<210>  263
<211>  2214
<212>  DNA
<213>  Adeno-associated virus

<400>  263
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ccgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgcctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgcac ctgggccttg cccacctaca ataaccacct ctacaagcaa      780

atctccagtg cttcaacggg ggccagcaac gacaaccact acttcggcta cagcaccccc      840

tgggggtatt ttgatttcaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaattgggg attccggccc aagagactca acttcaaact cttcaacatc      960

caagtcaagg aggtcacgac gaatgatggc gtcacaacca tcgctaataa ccttaccagc     1020

acggttcaag tcttctcgga ctcggagtac cagcttccgt acgtcctcgg ctctgcgcac     1080

cagggctgcc tccctccgtt cccggcggac gtgttcatga ttccgcaata cggctacctg     1140

acgctcaaca atggcagcca agccgtggga cgttcatcct tttactgcct ggaatatttc     1200

ccttctcaga tgctgagaac gggcaacaac tttaccttca gctacacctt tgaggaagtg     1260

cctctccaca gcagctacgc gcacagccag agcctggacc ggctgatgaa tcctctcatc     1320

gtccaatacc tgtattacct gaacagaact caaaatcagt ccggaagtgc ccaaaacaag     1380

gacttgctgt tcagccgtgg gtctccagct ggcatgtctg ttcagcccaa aaactggcta     1440

cctggaccct gttatcggca gcagcgcgtt tctaaaacaa aaacagacaa caacaacagc     1500

aattttacct ggactggtgc ttcaaaatat aacctcaatg ggcgtgaatc catcatcaac     1560

cctggcactg ctatggcctc acacaaagac gacgaagaca agttctttcc catgagcggt     1620

gtcatgattt ttggaaaaga gagcgccgga gcttcaaaca ctgcattgga caatgtcatg     1680

attacagacg aagaggaaat taaagccact aaccctgtgg ccaccgaaag atttgggacc     1740

gtggcagtca atttccagag cagcagcaca gaccctgcga ccggagatgt gcatgctatg     1800

ggagcattac ctggcatggt gtggcaagat agagacgtgt acctgcaggg tcccatttgg     1860

gccaaaattc ctcacacaga tggacacttt cacccgtctc ctcttatggg cggctttgga     1920

ctcaagaacc cgcctcctca gatcctcatc aaaaacacgc ctgttcctgc gaatcctccg     1980

gcggagtttt cagctacaaa gtttgcttca ttcatcaccc aatactccac aggacaagtg     2040

agtgtggaaa ttgaatggga gctgcagaaa gaaaacagca agcgctggaa tcccgaagtg     2100

cagtacacat ccaattatgc aaaatctgcc agcgttgatt ttactgtgga caacaatgga     2160

ctttatactg agcctcgccc cattggcacc cgttacctta cccgtcccct gtaa           2214


<210>  264
<211>  736
<212>  PRT
<213>  Adeno-associated virus

<400>  264

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Arg Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Glu Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Gly Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Pro Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Gly Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  265
<211>  2211
<212>  DNA
<213>  Adeno-associated virus

<400>  265
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcagacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctga gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagggccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg atccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

caatacctgt attacccgaa cagaactcaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaaggtaga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210>  266
<211>  736
<212>  PRT
<213>  Adeno-associated virus

<400>  266

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Arg Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Gly Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Pro Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Gly Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  267
<211>  736
<212>  PRT
<213>  Adeno-associated virus

<400>  267

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Arg Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Gly Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Gly Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  268
<211>  736
<212>  PRT
<213>  Adeno-associated virus

<400>  268

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Arg Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Gly Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  269
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  269
atggctgccg atggctatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcatagggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcggg gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata ccccaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcac aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccgtgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  270
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  270

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Arg Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Gly Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Pro Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Thr Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Val Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  271
<211>  2211
<212>  DNA
<213>  Adeno-associated virus

<400>  271
atggctgccg acggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcgggcgggc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actccccctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg atccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcactgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggccgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctctt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ctccacagca gctgcgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

caatacctgt attacctgaa cagaactcaa aatcagtccg gaagtgccca aaacagggac     1380

ttgctgttca gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccgcagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210>  272
<211>  736
<212>  PRT
<213>  Adeno-associated virus

<400>  272

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Pro Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Arg Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Ser Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Leu His Ser Ser Cys Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Arg Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Ala Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  273
<211>  736
<212>  PRT
<213>  Adeno-associated virus

<400>  273

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Leu His Ser Ser Cys Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Arg Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  274
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  274
atggctgccg atggctatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcatagggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgggg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacagt cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcac aacaaacact ccaagtggaa ccaccacgca gtcaaggctc     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacaatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  275
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  275

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Arg Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Gly Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Ser His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Thr Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asn Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  276
<211>  737
<212>  PRT
<213>  Adeno-associated virus

<400>  276

Arg Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu 
1               5                   10                  15      


Ser Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys 
            20                  25                  30          


Pro Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu 
        35                  40                  45              


Pro Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu 
    50                  55                  60                  


Pro Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr 
65                  70                  75                  80  


Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His 
                85                  90                  95      


Ala Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly 
            100                 105                 110         


Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu 
        115                 120                 125             


Pro Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys 
    130                 135                 140                 


Arg Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Thr Ser Thr Gly Ala Ser Asn Asp Asn 
            260                 265                 270         


His Tyr Phe Gly Tyr Gly Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Glu Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn 
        435                 440                 445             


Arg Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe 
    450                 455                 460                 


Ser Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu 
            500                 505                 510         


Asn Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Val Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe 
    530                 535                 540                 


Gly Lys Glu Ser Ala Gly Ala Ser Ser Thr Ala Leu Asp Asn Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Arg Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro 
            580                 585                 590         


Ala Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly 
705                 710                 715                 720 


Leu Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 735     


Leu 
    


<210>  277
<211>  736
<212>  PRT
<213>  Adeno-associated virus

<400>  277

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Thr Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Gly Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Glu Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Val Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Ser Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  278
<211>  2211
<212>  DNA
<213>  Adeno-associated virus

<400>  278
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gccagactgg cgactcagag      540

tcagtccccg atccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtactt caacgggggc cagcaacgac aaccactact tcggctacgg caccccctgg      840

gggtattttg atttcaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcgaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

caatacctgt attacctgaa cagaacacaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcaccgctg tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaagcactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210>  279
<211>  737
<212>  PRT
<213>  Adeno-associated virus

<400>  279

Arg Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu 
1               5                   10                  15      


Ser Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys 
            20                  25                  30          


Pro Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu 
        35                  40                  45              


Pro Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu 
    50                  55                  60                  


Pro Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr 
65                  70                  75                  80  


Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His 
                85                  90                  95      


Ala Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly 
            100                 105                 110         


Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu 
        115                 120                 125             


Pro Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys 
    130                 135                 140                 


Arg Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Thr Ser Thr Gly Ala Ser Asn Asp Asn 
            260                 265                 270         


His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Glu Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn 
        435                 440                 445             


Arg Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe 
    450                 455                 460                 


Ser Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu 
            500                 505                 510         


Asn Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Val Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe 
    530                 535                 540                 


Gly Lys Glu Ser Ala Gly Ala Ser Ser Thr Ala Leu Asp Asn Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Arg Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro 
            580                 585                 590         


Ala Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly 
705                 710                 715                 720 


Leu Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 735     


Leu 
    


<210>  280
<211>  737
<212>  PRT
<213>  Adeno-associated virus

<400>  280

Arg Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu 
1               5                   10                  15      


Ser Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys 
            20                  25                  30          


Pro Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu 
        35                  40                  45              


Pro Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu 
    50                  55                  60                  


Pro Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr 
65                  70                  75                  80  


Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His 
                85                  90                  95      


Ala Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly 
            100                 105                 110         


Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu 
        115                 120                 125             


Pro Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys 
    130                 135                 140                 


Arg Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Thr Ser Thr Gly Ala Ser Asn Asp Asn 
            260                 265                 270         


His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn 
        435                 440                 445             


Arg Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe 
    450                 455                 460                 


Ser Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu 
            500                 505                 510         


Asn Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Val Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe 
    530                 535                 540                 


Gly Lys Glu Ser Ala Gly Ala Ser Ser Thr Ala Leu Asp Asn Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Arg Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro 
            580                 585                 590         


Ala Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly 
705                 710                 715                 720 


Leu Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 735     


Leu 
    


<210>  281
<211>  737
<212>  PRT
<213>  Adeno-associated virus

<400>  281

Arg Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu 
1               5                   10                  15      


Ser Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys 
            20                  25                  30          


Pro Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu 
        35                  40                  45              


Pro Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu 
    50                  55                  60                  


Pro Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr 
65                  70                  75                  80  


Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His 
                85                  90                  95      


Ala Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly 
            100                 105                 110         


Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu 
        115                 120                 125             


Pro Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys 
    130                 135                 140                 


Arg Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Thr Ser Thr Gly Ala Ser Asn Asp Asn 
            260                 265                 270         


His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn 
        435                 440                 445             


Arg Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe 
    450                 455                 460                 


Ser Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu 
            500                 505                 510         


Asn Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Val Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe 
    530                 535                 540                 


Gly Lys Glu Ser Ala Gly Ala Asn Ser Thr Ala Leu Asp Asn Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Arg Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro 
            580                 585                 590         


Ala Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly 
705                 710                 715                 720 


Leu Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 735     


Leu 
    


<210>  282
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  282
atggctgccg atggttatct tccagattgg ctcaaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcgggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agtacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaacagga      480

aaagcgggcc agcagcctgc gagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaag ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggctctgccc acctacaaca accatctgta caagcagatc      780

tccagccaat caggagccag caacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaggaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc ccggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgcttc gtaccggaaa caactttacc ttcagctaca cctttgagga tgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgca gtccaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg ccagccacaa ggacgatgaa gaaaagtttt ttcctcaaag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcagaac caccaatccc gtggccacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctactgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgcacctgc aggggcctat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt tggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcaaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtatt ccacagggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaaccccga gatccagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  283
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  283

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Lys Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Gly Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu Tyr Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Ser Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Pro Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val His Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  284
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  284
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcagagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaaaaga ttaaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acatacaaca accacctcta caagcaaatc      780

tccagccaat caggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaaaaga ctcaacttca agctctttaa tattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tgggctcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttcag ttcagctaca cttttgaaga cgtgcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa gacacaaaca aatagtggaa ctcttcagca gtctcggcta     1380

ctgtttagcc aagctggacc aaccaacatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctgtcaaaa caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cagctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagtcgcaa ggatgacgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgccaac gacgcggatt tggaaaatgt catgattaca     1680

gatgaagaag aaatcagggc caccaatccc gtggctacgg agcagtacgg gactgtgtca     1740

aataatttgc aaaactcaaa cactggtcca actactggaa ctgtcaatca ccaaggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactga tgggaggttt tggactcaaa     1920

cacccgcctc ctcagatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  285
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  285

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Thr Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Asn Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser Arg Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Ala Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Thr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  286
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  286
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgggg aacctgtcaa gacggctcca      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcggct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcac aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacaatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtacgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  287
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  287

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Gly Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Gly Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Thr Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asn Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  288
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  288
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgggg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa tcggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta cagacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

agcaacggga gtcaggcagt aggacgctct tcattttact gcccggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcac aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacaatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacctaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atttgtaa                  2208


<210>  289
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  289

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Gly Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Arg His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Arg Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Ser Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Pro Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Thr Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asn Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Pro Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  290
<211>  2205
<212>  DNA
<213>  Adeno-associated virus

<400>  290
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaaaaga ctgaatttcg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcagacag ccaccagcag cccccacaag tttgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accaccttta caagcaaatc      780

tccagccaat caggagcctc aaacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttcag ttcagctaca cttttgaaga cgtgcctttc     1260

cacagcagct acgctcacag ccagagtttg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctaaacag aacacaaaca gctagtggaa ctcagcagtc tcggctactg     1380

tttagccaag ctggacccac aagcatgtct cttcaagcta aaaactggct gcctggaccg     1440

tgttatcgcc agcagcgttt gtcaaagcag gcaaacgaca acaacaacag caactttccc     1500

tggactggag ctaccaagta ctacctcaat ggcagagact ctttggtgaa cccgggcccg     1560

gccatggcca gccacaagga cgatgaagaa aagtttttcc ccatgcatgg aaccctaata     1620

tttggtaaag aaggaacaaa tgctaccaac gcggaattgg aaaatgtcat gattacagat     1680

gaagaggaaa tcaggaccac caatcccgtg gctacagagc agtacggata tgtgtcaaat     1740

aatttgcaaa actcaaatac tgctgcaagt actgaaactg tgaatcacca aggagcatta     1800

cctggtatgg tgtggcagga tcgagacgtg tacctgcagg gacccatttg ggccaagatt     1860

cctcacaccg atggacactt tcatccttct ccactgatgg gaggttttgg actcaaacac     1920

ccgcctcctc agattatgat caaaaacact cccgttccag ccaatcctcc cacaaacttc     1980

agttctgcca agtttgcttc cttcatcaca cagtattcca cgggacaggt cagcgtggag     2040

atcgagtggg agctgcagaa ggagaacagc aaacgctgga atcccgaaat tcagtacact     2100

tccaactaca acaaatctgt taatgtggac tttactgtgg acactaatgg tgtgtattca     2160

gagcctcgcc ccattggcac cagatacctg actcgtaatc tgtaa                     2205


<210>  291
<211>  734
<212>  PRT
<213>  Adeno-associated virus

<400>  291

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Arg Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Thr Ala Ser Gly Thr Gln Gln Ser Arg Leu Leu Phe Ser Gln Ala 
    450                 455                 460                 


Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly Pro 
465                 470                 475                 480 


Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn Asn 
                485                 490                 495     


Ser Asn Phe Pro Trp Thr Gly Ala Thr Lys Tyr Tyr Leu Asn Gly Arg 
            500                 505                 510         


Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp Asp 
        515                 520                 525             


Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys Glu 
    530                 535                 540                 


Gly Thr Asn Ala Thr Asn Ala Glu Leu Glu Asn Val Met Ile Thr Asp 
545                 550                 555                 560 


Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly 
                565                 570                 575     


Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Ala Ala Ser Thr Glu 
            580                 585                 590         


Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp Arg 
        595                 600                 605             


Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu 
        675                 680                 685             


Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn 
    690                 695                 700                 


Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr Ser 
705                 710                 715                 720 


Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 


<210>  292
<211>  3160
<212>  DNA
<213>  Adeno-associated virus

<400>  292
acccttcact aaagggacta gtcctgcagg tttaaacgaa ttcgcccttg ctgcgtcaac       60

tggaccaatg agaactttcc cttcaacgac tgtgtcgaca agatggtgat ttggtgggag      120

gaggggaaga tgaccgccaa ggtcgtggag tcggccaaag ccattctcgg aggaagcaag      180

gtgcgcgtgg accagaaatg caagtcctcg gcccagatag atccgactcc cgtgatcgtc      240

acctccaaca ccaacatgtg cgccgtgatt gacgggaact caacgacctt cgaacaccag      300

cagccgttgc aagaccggat gttcaaattt gaactcaccc gccgtctgga tcatgacttt      360

gggaaggtca ccaagcggga agtcaaagac tttttccggt gggcaaagga tcacgtggtt      420

gaggtggagc atgaattcta cgtcaaaaag ggtggagcca agaaaagacc cgcccctagt      480

gacgcagata taagtgagcc caaacgggtg cgcgagtcag ttgcgcagcc atcgacgtca      540

gacgcggaag cttcgatcaa ctacgcggac aggtaccaaa acaaatgttc tcgtcacgtg      600

ggcatgaatc tgatgctgtt tccctgcaga caatgcgaga gaatgaatca aaattcaaat      660

atctgcttca ctcacggaca gaaagactgt ttagagtgct ttcccgtgtc agaatctcaa      720

cctgtttctg tcgtcaaaaa ggcgtatcag aaactgtgct acattcatca tatcatggga      780

aaggtgccag acgcttgcac tgcctgcgat ctggtcaatg tggatttgga tgactgcatc      840

tctgaacaat aaatgattta aatcaggtat ggctgccgat ggttatcttc cagattggct      900

cgaggacact ctctctgaag gaataagaca gtggtggaag ctcaaacctg gcccaccacc      960

accaaagccc gcagagcggc ataaggacga cagcaggggt cttgtgcttc ctgggtacaa     1020

gtacctcgga cccttcaacg gactcgacaa gggagagccg gtcaacgagg cagacgccgc     1080

ggccctcgag cacgacaagg cctacgaccg gcagctcgac agcggagaca acccgtacct     1140

caagtacaac cacgccgacg cggagtttca ggagcgtctt aaagaagata cgtcttttgg     1200

gggcaacctc ggacgagcag tcttccaggc gaaaaagagg gttcttgaac ctctgggcct     1260

ggttgaggaa cctgttaaga cggctccggg aaaaaagagg ccggtagagc actctcctgc     1320

ggagccagac tcctcctcgg gaaccggaaa agcgggccag cagcctgcaa gaaaaagact     1380

gaatttcggt cagactggag acgcagactc cgtacctgac ccccagcctc tcagacagcc     1440

accagcagcc cccacaagtt tgggatctac tacaatggct acaggcagtg gcgcaccaat     1500

ggcagacaat aacgagggtg ccgatggagt gggtaattcc tcaggaaatt ggcattgcga     1560

ttcccaatgg ctgggcgaca gagtcatcac caccagcacc cgaacctggg ccctgcccac     1620

ctacaacaac cacctttaca agcaaatctc cagccaatca ggagcctcaa acgacaacca     1680

ctactttggc tacagcaccc cctgggggta ttttgacttc aacagattcc actgccactt     1740

ttcaccacgt gactggcaaa gactcatcaa caacaactgg ggattccgac ccaagagact     1800

caacttcaag ctctttaaca ttcaagtcaa agaggtcacg cagaatgacg gtacgacgac     1860

gattgccaat aaccttacca gcacggttca ggtgtttact gactcggagt accagctccc     1920

gtacgtcctc ggctcggcgc atcaaggatg cctcccgccg tttccagcgg acgtcttcat     1980

ggtcccacag tatggatacc tcaccctgaa caacgggagt caggcggtag gacgctcttc     2040

cttttactgc ctggagtact ttccttctca gatgctgcgt actggaaaca actttcagtt     2100

cagctacact tttgaagacg tgcctttcca cagcagctac gctcacagcc agagtttgga     2160

tcggctgatg aatcctctga tcgaccagta cctgtattat ctaaacagaa cacaaacagc     2220

tagtggaact cagcagtctc ggctactgtt tagccaagct ggacccacaa gcatgtctct     2280

tcaagctaaa aactggctgc ctggaccgtg ttatcgccag cagcgtttgt caaagcaggc     2340

aaacgacaac aacaacagca actttccctg gactggagct accaagtact acctcaatgg     2400

cagagactct ttggtgaacc cgggcccggc catggccagc cacaaggacg atgaagaaaa     2460

gtttttcccc atgcatggaa ccctaatatt tggtaaagaa ggaacaaatg ctaccaacgc     2520

ggaattggaa aatgtcatga ttacagatga agaggaaatc aggaccacca atcccgtggc     2580

tacagagcag tacggatatg tgtcaaataa tttgcaaaac tcaaatactg ctgcaagtac     2640

tgaaactgtg aatcaccaag gagcattacc tggtatggtg tggcaggatc gagacgtgta     2700

cctgcaggga cccatttggg ccaagattcc tcacaccgat ggacactttc atccttctcc     2760

actgatggga ggttttggac tcaaacaccc gcctcctcag attatgatca aaaacactcc     2820

cgttccagcc aatcctccca caaacttcag ttctgccaag tttgcttcct tcatcacaca     2880

gtattccacg ggacaggtca gcgtggagat cgagtgggag ctgcagaagg agaacagcaa     2940

acgctggaat cccgaaattc agtacacttc caactacaac aaatctgtta atgtggactt     3000

tactgtggac actaatggtg tgtattcaga gcctcgcccc attggcacca gatacctgac     3060

tcgtaatctg taattgcttg ttaatcaata aaccgtttaa ttcgtttcag ttgaactttg     3120

gtctctgcga agggcgaatt cgcggccgct aaatcaatcg                           3160


<210>  293
<211>  734
<212>  PRT
<213>  Adeno-associated virus

<400>  293

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys Arg Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Gly Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Thr Ala Ser Gly Thr Gln Gln Ser Arg Leu Leu Phe Ser Gln Ala 
    450                 455                 460                 


Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly Pro 
465                 470                 475                 480 


Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn Asn 
                485                 490                 495     


Ser Asn Phe Pro Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Gly 
            500                 505                 510         


Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp Asp 
        515                 520                 525             


Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys Glu 
    530                 535                 540                 


Gly Thr Asn Ala Thr Asn Ala Glu Leu Glu Asn Val Met Ile Thr Asp 
545                 550                 555                 560 


Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly 
                565                 570                 575     


Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Ala Ala Ser Thr Glu 
            580                 585                 590         


Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp Arg 
        595                 600                 605             


Asp Val Tyr Leu Arg Gly Pro Ile Trp Ala Lys Ile Pro His Ala Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu 
        675                 680                 685             


Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn 
    690                 695                 700                 


Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr Ser 
705                 710                 715                 720 


Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 


<210>  294
<211>  3157
<212>  DNA
<213>  Adeno-associated virus

<400>  294
ctcactaagg gactagtcct gcaggtttaa acgaattcgc ccttgctgcg tcaactggac       60

caatgagaac tttcccttca acgactgtgt cgacaagatg gtgatttggt gggaggaggg      120

gaagatgacc gccaaggtcg tggagtcggc caaagccact ctcggaggaa gcaaggtgcg      180

cgtggaccag aaacgcaagt cctcggccca gatagatccg actcccgtga tcgtcacctc      240

caacaccaac atgtgcgccg tgattgacgg gaactcaacg accttcgaac accagcagcc      300

gttgcaagac cgaatgttca aatttgaact cacccgccgt ctggatcatg acttcgggaa      360

ggtcaccaag caggaagtca aagacttttt ccggtgggca aaggatcacg tggttgaggt      420

ggagcatgaa ttctacgtca aaaagggtgg agccaagaaa agacccgccc ctagtgacgc      480

agatataagt gagcccaaac gggtgcgcga gtcagttgcg cagccatcga cgtcagacgc      540

ggaagcttcg atcaactacg cggacaggta ccaaaacaaa tgttctcgtc acgtgggcat      600

gaatctgatg ctgtttccct gcagacaatg cgagagaatg aatcaaaatt caaatatctg      660

cttcactcac ggacagaaag actgtttaga gtgctttccc gtgtcagaat ctcaacctgt      720

ttctgtcgtc aaaaaggcgt atcagaaact gtgctacatt catcatatca tgggaaaggt      780

gccagacgct tgcactgcct gcgatctggt caatgtggat ttggatgact gcatctctga      840

acaataaatg atttaaatca ggtatggctg ccgatggtta tcttccagat tggctcgagg      900

acactctctc tgaaggaata agacagtggt ggaagctcaa acctggccca ccaccaccaa      960

agcccgcaga gcggcataag gacgacagca ggggtcttgt gcttcctggg tacaagtacc     1020

tcggaccctt caacggactc gacaagggag agccggtcaa cgaggcagac gccgcggctc     1080

tcgagcacga caaggcctac gaccggcagc tcgacagcgg agacaacccg tacctcaagt     1140

acaaccacgc cgacgcggag tttcaggagc gtcttaaaga agatacgtct tttgggggca     1200

acctcggacg agcagtcttc caggcgaaaa agagggttct tgaacctctg ggcctggttg     1260

aggaacctgt taagacggct ccgggaaaaa agaggccggt agagcactct cctgcggagc     1320

cagactcctc ctcgggaacc ggaaaagcgg gccagcagcc tgcaagaaaa agactgaatt     1380

tcggtcagac tggagacgca gactccgtac ctgaccccca gcctctcgga cagccaccag     1440

cagcccccac aagtttggga tctactacaa tggctacagg cagtggcgca ccaatggcag     1500

acaataacga gggtgccgat ggagtgggta attcctcagg aaattggcat tgcgattccc     1560

aatggctggg cgacagagtc atcaccacca gcacccgaac ctgggccctg cccacctaca     1620

acaaccacct ttacaagcaa atctccagcc aatcaggagc ctcaaacgac aaccactact     1680

ttggctacag caccccctgg gggtattttg acttcaacag attccactgc cgcttttcac     1740

cacgtgactg gcaaagactc atcaacaaca actggggatt ccgacccaag agactcaact     1800

tcaagctctt taacattcaa gtcaaagagg tcacgcagaa tgacggtacg acgacgattg     1860

ccaataacct taccagcacg gttcaggtgt ttactgactc ggagtaccag ctcccgtacg     1920

tcctcggctc ggcgcatcaa ggatgcctcc cgccgtttcc agcggacgtc ttcatggtcc     1980

cacagtatgg atacctcacc ctgaacaacg ggagtcaggc ggtaggacgc tcttcctttt     2040

actgcctgga gtactttcct tctcagatgc tgcgtactgg aaacaacttt cagttcagct     2100

acacttttga agacgtgcct ttccacagca gctacgctca cagccagggt ttggatcggc     2160

tgatgaatcc tctgatcgac cagtacctgt attatctaaa cagaacacaa acagctagtg     2220

gaactcagca gtctcggcta ctgtttagcc aagctggacc cacaagcatg tctcttcaag     2280

ctaaaaactg gctgcctgga ccgtgttatc gccagcagcg tttgtcaaag caggcaaacg     2340

acaacaacaa cagcaacttt ccctggactg gagctaccaa gtaccacctc aatggcggag     2400

actctttggt gaacccgggc ccggccatgg ccagccacaa ggacgatgaa gaaaagtttt     2460

tccccatgca tggaacccta atatttggta aagaaggaac aaatgctacc aacgcggaat     2520

tggaaaatgt catgattaca gatgaagagg aaatcaggac caccaatccc gtggctacag     2580

agcagtacgg atatgtgtca aataatttgc aaaactcaaa tactgctgca agtactgaaa     2640

ctgtgaatca ccaaggagca ttacctggta tggtgtggca ggatcgagac gtgtacctgc     2700

ggggacccat ttgggccaag attcctcacg ccgatggaca ctttcatcct tctccactga     2760

tgggaggttt tggactcaaa cacccgcctc ctcagattat gatcaaaaac actcccgttc     2820

cagccaatcc tcccacaaac ttcagttctg ccaagtttgc ttccttcatc acacagtatt     2880

ccacgggaca ggtcagcgtg gagatcgagt gggagctgca gaaggagaac agcaaacgct     2940

ggaatcccga aattcagtac acttccaact acaacaaatc tgttaatgtg gactttactg     3000

tggacactaa tggtgtgtat tcagagcctc gccccattgg caccagatac ctgactcgta     3060

atctgtaatt gcttgttaat caataaaccg tttaattcgt ttcagttgaa ctttggtctc     3120

tgcgaagggc gaattcgcgg ccgctaaatt caattcg                              3157


<210>  295
<211>  734
<212>  PRT
<213>  Adeno-associated virus

<400>  295

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Cys Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Thr Ala Ser Gly Thr Gln Gln Ser Arg Leu Leu Phe Ser Gln Ala 
    450                 455                 460                 


Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly Pro 
465                 470                 475                 480 


Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn Asn 
                485                 490                 495     


Ser Asn Phe Pro Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg 
            500                 505                 510         


Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp Asp 
        515                 520                 525             


Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys Glu 
    530                 535                 540                 


Gly Thr Asn Ala Thr Asn Ala Glu Leu Glu Asn Val Met Ile Thr Asp 
545                 550                 555                 560 


Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly 
                565                 570                 575     


Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Ala Ala Ser Thr Glu 
            580                 585                 590         


Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp Arg 
        595                 600                 605             


Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu 
        675                 680                 685             


Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn 
    690                 695                 700                 


Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr Ser 
705                 710                 715                 720 


Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 


<210>  296
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  296
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctggatac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggca accagcctgc aagaaaaaga ttgaatttcg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcat ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcgtc      720

accaccagca cccgcacctg ggccctgccc acctacaaca accacctcta caagcagatt      780

tccagccaat caggagccag caacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcgccac gcgactggca gagactcatc      900

aacaacaact ggggattccg gcccaaaaga ctcaacttca agctgtttaa cattcaagtc      960

aaggaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgacttgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gcaccggaaa caactttacc ttcagctaca cttttgaaga cgttcctttc     1260

cacagcagct acgctcacag tcaaagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccactacgca gtccaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg ccagccacaa ggacgatgaa gaaaagtttt ttcctcaaag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcccat ctgggcaaaa     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt tggacttaaa     1920

caccctcctc cacagattct cattaagaat accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagcgcgg caaagtttgc ttccttcatc acacagtatt ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggggtgtat     2160

tcagagcctc gccctattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  297
<211>  3159
<212>  DNA
<213>  Adeno-associated virus

<400>  297
gattgattta gcggccgcga attcgccctt gctgcgtcaa ctggaccaat gagaactttc       60

ccttcaacga ttgcgtcgac aagatggtga tctggtggga ggagggaaag atgaccgcca      120

aggtcgtgga gtcggccaaa gccattctcg gaggaagcaa ggtgcgtgtg gaccaaaagt      180

gcaagtcttc ggcccagatc gacccgactc ccgtgatcgt cacctccaac accaacatgt      240

gcgccgtgat tgatggaaac tcaacgacct tcgagcacca gcagccgttg caagaccgga      300

tgttcaaatt tgaacttacc cgccgtctgg atcatgactt tggaaaggtc accaagcagg      360

aagtgaaaga ctttttccgg tgggcaaagg atcacgtggt tgaggtggag catgagttct      420

acgtcaaaaa gggtggagcc aaaaaaagac ccgcccccag tgacgcagat ataagtgagc      480

ccaaacgggc gcgcgagtca gttgcgcagc catcgacgtc agacgcggaa gcttcgatca      540

actacgcgga caggtaccaa aacaaatgtt ctcgtcacgt gggcatgaat ctgatgctgt      600

ttccctgcag acaatgcgag agaatgaatc agaattcaaa tatctgcttc actcacggac      660

agaaagactg tccatagtgc tttcccgtgt cagaatctca acccgtttct gtcgtcaaaa      720

aggcgtatca gaaactgtgc tacattcatc acatcatggg aaaggtgcca gacgcttgca      780

ctgcttgcga cctggtcaat gtggatttgg atgactgcat ctctgaacaa taaatgattt      840

aaatcaggta tggctgccga tggttatctt ccagattggc tcgaggacac tctctctgaa      900

ggaataagac agtggtggaa gctcaaacct ggcccaccac caccaaagcc cgcagagcgg      960

cataaggacg acagcagggg tcttgtgctt cctggataca agtacctcgg acccttcaac     1020

ggactcgaca agggagagcc ggtcaacgag gcagacgccg cggccctcga gcacgacaag     1080

gcctacgacc ggcagctcga cagcggagac aacccgtacc tcaagtacaa ccacgccgac     1140

gcggagtttc aggagcgcct taaagaagat acgtcttttg ggggcaacct cggacgagca     1200

gtcttccagg cgaaaaagag ggttcttgaa cctctgggcc tggttgagga acctgttaag     1260

acggctccgg gaaaaaagag gccggtagag cactctcctg tggagccaga ctcctcctcg     1320

ggaaccggaa aagcgggcaa ccagcctgca agaaaaagat tgaatttcgg tcagactgga     1380

gacgcagact ccgtacctga cccccagcct ctcggacagc caccagcatc cccctctggt     1440

ctgggaacta atacgatggc tacaggcagt ggcgcaccaa tggcagacaa taacgagggc     1500

gccgacggag tgggtaattc ctcgggaaat tggcattgcg attccacatg gatgggcgac     1560

agagtcgtca ccaccagcac ccgcacctgg gccctgccca cctacaacaa ccacctctac     1620

aagcagattt ccagccaatc aggagccagc aacgacaacc actactttgg ctacagcacc     1680

ccttgggggt attttgactt caacagattc cactgccact tttcgccacg cgactggcag     1740

agactcatca acaacaactg gggattccgg cccaaaagac tcaacttcaa gctgtttaac     1800

attcaagtca aggaggtcac gcagaatgac ggtacgacga cgattgccaa taaccttacc     1860

agcacggttc aggtgtttac tgacttggag taccagctcc cgtacgtcct cggctcggcg     1920

catcaaggat gcctcccgcc gttcccagca gacgtcttca tggtgccaca gtatggatac     1980

ctcaccctga acaacgggag tcaggcggta ggacgctctt ccttttactg cctggagtac     2040

tttccttctc agatgcttcg caccggaaac aactttacct tcagctacac ttttgaagac     2100

gttcctttcc acagcagcta cgctcacagt caaagtctgg accgtctcat gaatcctctc     2160

atcgaccagt acctgtatta cttgagcaga acaaacactc caagcggaac cactacgcag     2220

tccaggcttc agttttctca ggccggagcg agtgacattc gggaccagtc taggaactgg     2280

cttcctggac cctgttaccg ccagcagcga gtatcaaaga cagctgcgga taacaacaac     2340

agtgaatact cgtggactgg agctaccaag taccacctca atggcagaga ctctctggtg     2400

aatccgggcc cggccatggc cagccacaag gacgatgaag aaaagttttt tcctcaaagc     2460

ggggttctca tctttgggaa gcaaggctca gagaaaacaa atgtggacat tgaaaaggtc     2520

atgattacag acgaagagga aatcaggacc accaatcccg tggctacgga gcagtatggt     2580

tctgtatcta ccaacctcca gagcggcaac acacaagcag ctacctcaga tgtcaacaca     2640

caaggcgttc ttccaggcat ggtctggcag gacagagacg tgtacctgca ggggcccatc     2700

tgggcaaaaa ttccacacac ggacggacat tttcacccct ctcccctcat gggcggattt     2760

ggacttaaac accctcctcc acagattctc attaagaata ccccggtacc tgcgaatcct     2820

tcgaccacct tcagcgcggc aaagtttgct tccttcatca cacagtattc cacggggcag     2880

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaatcccgaa     2940

attcagtaca cttccaacta caacaaatct gttaatgtgg actttactgt ggacactaat     3000

ggggtgtatt cagagcctcg ccctattggc accagatacc tgactcgtaa tctgtaattg     3060

cttgttaatc aataaaccgt ttaattcgtt tcagttgaac tttggtctct gcgaagggcg     3120

aattcgttta aacctgcagg actagtccct ttagtgagg                            3159


<210>  298
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  298

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ser Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Val 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Leu Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  299
<211>  2205
<212>  DNA
<213>  Adeno-associated virus

<400>  299
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaaagcccg cagagcggca taaggacgac      120

agcaggggtc ttgtgcttcc tggatacaag tacctcggac ccttcaacgg actcgacaag      180

ggagagccgg tcaacgaggc agacgccgcg gccctcgagc acgacaaggc ctacgaccgg      240

cagctcgaca gcggagacaa cccgtacctc aagtacaacc acgccgacgc ggagtttcag      300

gagcgcctta aagaagatac gtcttttggg ggcaacctcg gacgagcagt cttccaggcg      360

aaaaagaggg ttcttgaacc tctgggcctg gttgaggaac ctgttaagac ggctccggga      420

aaaaagaggc ccgtagagca ctctcctgtg gagccagact cctcctcggg aaccggaaaa      480

gcgggcaacc agcctgcaag aaaaagattg aatttcggtc agactggaga cgcagactcc      540

gtacctgacc cccagcctct cggacagcca ccagcagccc cctctggtct gggaactaat      600

acgatggcta caggcagtgg cgcaccaatg gcagacaata acgagggcgc cgacggagtg      660

ggtaattcct cgggagattg gcattgcgat tccacatgga tgggcgacag agtcatcacc      720

accagcaccc gcacctgggc cctgcccacc tacaacaacc acctctacaa gcagatttcc      780

agccaatcag gagccagcaa tgacaaccac tactttggct acagcacccc ttgggggtat      840

tttgacttca acagattcca ctgccacttt tcgccacgcg actggcagag actcatcaac      900

aacaactggg gattccggcc caaaagactc aacctcaagc tgtttaacat tcaagtcaag      960

gaggtcacgc agaatgacgg tacgacgacg attgccaata accttaccag cacggttcag     1020

gtgtttactg acttggagta ccagctcccg tacgtcctcg gctcggcgca tcaaggatgc     1080

ctcccgccgt tcccagcaga cgtcttcatg gtgccacagt atggatacct caccctgaac     1140

aacgggagtc aggcggtagg acgctcttcc ttttactgcc tggagtactt tccttctcag     1200

atgcttcgta ccggaaacaa ctttaccttc agctacactt ttgaagacgt tcctttccac     1260

agcagctacg ctcacagtca aagtctggac cgtctcatga atcctctcat cgaccagtac     1320

ctgtattact tgagcagaac aaacactcca agcggaacca ctacgcagtc caggcttcag     1380

ttttctcagg ccggagcgag tgacattcgg gaccagtcta ggaactggct tcctggaccc     1440

tgttaccgcc agcagcgagt atcaaagaca gctgcggata acaacaacgg tgaatactcg     1500

tggactggag ctaccaagta ccacctcaat ggcagagact ctctggtgaa tccgggcccg     1560

gccatggcca gccacaagga cgatgaagaa aagttttttc ctcaaagcgg ggttctcatc     1620

tttgggaagc aaggctcaga gaaaacaaat gtggacattg aaaaggtcat gattacagac     1680

gaagaggaaa tcaggaccac caatcccgtg gctacggagc agtatggttc tgtatctacc     1740

aacctccaga gcggcaacac acgagcagct acctcagatg tcaacacaca aggcgttctt     1800

ccaggcatgg tctggcagga cagagacgtg tacctgcagg ggcccatctg ggcaaaaatt     1860

ccacacacgg acggacattt tcacccctct cccctcatgg gcggatttgg acttaaacac     1920

cctcctccac agattctcat taagaatacc ccggtacctg cgaatccttc gaccaccttc     1980

agcgcggcaa agtttgcttc cttcatcaca cagtattcca cggggcaggt cagcgtggag     2040

atcgagtggg agctgcagaa ggagaacagc aaacgctgga atcccgaaat tcagtacact     2100

tccaactaca acaaatctgt taatgtggac tttactgtgg acactaatgg ggtgtattca     2160

gagcctcgcc ctattggcac cagatacctg actcgtaatc tgtaa                     2205


<210>  300
<211>  3156
<212>  DNA
<213>  Adeno-associated virus

<400>  300
cgattgaatt tagcggccgc gaattcgccc ttgctgcgtc aacggaccaa tgagaacttt       60

cccttcaacg attgcgtcga caagatggtg atctggtggg aggagggaaa gatgaccgcc      120

aaggtcgtgg agtcggccaa agccattctc ggaggaagca aggtgcgtgt ggaccaaaag      180

tgcaagtctt cggcccagat cgacccgact cccgtgatcg tcacctccaa caccaacatg      240

tgcgccgtga ttgatggaaa ctcaacgacc ttcgagcacc agcagccgtt gcaagaccgg      300

atgttcaaat ttgaacttac ccgccgtctg gatcatgact ttggaaaggt caccaagcag      360

gaagtgaaag actttttccg gtgggcaaag gatcacgtgg ttgaggtgga gcatgagttc      420

tacgtcaaaa agggtggagc caaaaaaaga cccgccccca gtgacgcaga tataagtgag      480

cccaaacggg cgcgcgagtc agttgcgcag ccatcgacgt cagacgcgga agcttcgatc      540

aactacgcgg acaggtacca aaacaaatgt tctcgtcacg tgggcatgaa tctgatgctg      600

tttccctgca gacaatgcga gcgaatgaat cagaattcaa atatctgctt cactcacgga      660

cagaaagact gtttagagtg ctttcccgtg tcagaatctc aacccgtttc tgtcgtcaaa      720

aaggcgtatc agaaactgtg ctacattcat cacatcatgg gaaaggtgcc agacgcttgc      780

actgcttgcg acctggtcaa tgtggatttg gatgactgca tctctgaaca ataaatgatt      840

taaatcaggt atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga      900

aggaataaga cagtggtgga agctcaaacc tggcccacca ccaaagcccg cagagcggca      960

taaggacgac agcaggggtc ttgtgcttcc tggatacaag tacctcggac ccttcaacgg     1020

actcgacaag ggagagccgg tcaacgaggc agacgccgcg gccctcgagc acgacaaggc     1080

ctacgaccgg cagctcgaca gcggagacaa cccgtacctc aagtacaacc acgccgacgc     1140

ggagtttcag gagcgcctta aagaagatac gtcttttggg ggcaacctcg gacgagcagt     1200

cttccaggcg aaaaagaggg ttcttgaacc tctgggcctg gttgaggaac ctgttaagac     1260

ggctccggga aaaaagaggc ccgtagagca ctctcctgtg gagccagact cctcctcggg     1320

aaccggaaaa gcgggcaacc agcctgcaag aaaaagattg aatttcggtc agactggaga     1380

cgcagactcc gtacctgacc cccagcctct cggacagcca ccagcagccc cctctggtct     1440

gggaactaat acgatggcta caggcagtgg cgcaccaatg gcagacaata acgagggcgc     1500

cgacggagtg ggtaattcct cgggagattg gcattgcgat tccacatgga tgggcgacag     1560

agtcatcacc accagcaccc gcacctgggc cctgcccacc tacaacaacc acctctacaa     1620

gcagatttcc agccaatcag gagccagcaa tgacaaccac tactttggct acagcacccc     1680

ttgggggtat tttgacttca acagattcca ctgccacttt tcgccacgcg actggcagag     1740

actcatcaac aacaactggg gattccggcc caaaagactc aacctcaagc tgtttaacat     1800

tcaagtcaag gaggtcacgc agaatgacgg tacgacgacg attgccaata accttaccag     1860

cacggttcag gtgtttactg acttggagta ccagctcccg tacgtcctcg gctcggcgca     1920

tcaaggatgc ctcccgccgt tcccagcaga cgtcttcatg gtgccacagt atggatacct     1980

caccctgaac aacgggagtc aggcggtagg acgctcttcc ttttactgcc tggagtactt     2040

tccttctcag atgcttcgta ccggaaacaa ctttaccttc agctacactt ttgaagacgt     2100

tcctttccac agcagctacg ctcacagtca aagtctggac cgtctcatga atcctctcat     2160

cgaccagtac ctgtattact tgagcagaac aaacactcca agcggaacca ctacgcagtc     2220

caggcttcag ttttctcagg ccggagcgag tgacattcgg gaccagtcta ggaactggct     2280

tcctggaccc tgttaccgcc agcagcgagt atcaaagaca gctgcggata acaacaacgg     2340

tgaatactcg tggactggag ctaccaagta ccacctcaat ggcagagact ctctggtgaa     2400

tccgggcccg gccatggcca gccacaagga cgatgaagaa aagttttttc ctcaaagcgg     2460

ggttctcatc tttgggaagc aaggctcaga gaaaacaaat gtggacattg aaaaggtcat     2520

gattacagac gaagaggaaa tcaggaccac caatcccgtg gctacggagc agtatggttc     2580

tgtatctacc aacctccaga gcggcaacac acgagcagct acctcagatg tcaacacaca     2640

aggcgttctt ccaggcatgg tctggcagga cagagacgtg tacctgcagg ggcccatctg     2700

ggcaaaaatt ccacacacgg acggacattt tcacccctct cccctcatgg gcggatttgg     2760

acttaaacac cctcctccac agattctcat taagaatacc ccggtacctg cgaatccttc     2820

gaccaccttc agcgcggcaa agtttgcttc cttcatcaca cagtattcca cggggcaggt     2880

cagcgtggag atcgagtggg agctgcagaa ggagaacagc aaacgctgga atcccgaaat     2940

tcagtacact tccaactaca acaaatctgt taatgtggac tttactgtgg acactaatgg     3000

ggtgtattca gagcctcgcc ctattggcac cagatacctg actcgtaatc tgtaattgct     3060

tgttaatcaa taaaccgttt aattcgtttc agttgaactt tggtctctgc gaagggcgaa     3120

ttcgtttaaa cctgcaggac tagtcccttt agtgag                               3156


<210>  301
<211>  734
<212>  PRT
<213>  Adeno-associated virus

<400>  301

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Lys 
            20                  25                  30          


Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro Val 
    50                  55                  60                  


Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Arg 
65                  70                  75                  80  


Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg Pro 
    130                 135                 140                 


Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly Lys 
145                 150                 155                 160 


Ala Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr Gly 
                165                 170                 175     


Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro Ala 
            180                 185                 190         


Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly Ala 
        195                 200                 205             


Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser Ser 
    210                 215                 220                 


Gly Asp Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr 
225                 230                 235                 240 


Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr 
                245                 250                 255     


Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr Phe 
            260                 265                 270         


Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys 
        275                 280                 285             


His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly 
    290                 295                 300                 


Phe Arg Pro Lys Arg Leu Asn Leu Lys Leu Phe Asn Ile Gln Val Lys 
305                 310                 315                 320 


Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu Thr 
                325                 330                 335     


Ser Thr Val Gln Val Phe Thr Asp Leu Glu Tyr Gln Leu Pro Tyr Val 
            340                 345                 350         


Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val 
        355                 360                 365             


Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln 
    370                 375                 380                 


Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln 
385                 390                 395                 400 


Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu Asp 
                405                 410                 415     


Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu 
            420                 425                 430         


Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Asn 
        435                 440                 445             


Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln Ala 
    450                 455                 460                 


Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly Pro 
465                 470                 475                 480 


Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn Asn 
                485                 490                 495     


Gly Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg 
            500                 505                 510         


Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp Asp 
        515                 520                 525             


Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys Gln 
    530                 535                 540                 


Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr Asp 
545                 550                 555                 560 


Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly 
                565                 570                 575     


Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Arg Ala Ala Thr Ser 
            580                 585                 590         


Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp Arg 
        595                 600                 605             


Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu 
        675                 680                 685             


Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn 
    690                 695                 700                 


Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr Ser 
705                 710                 715                 720 


Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 


<210>  302
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  302
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtacg accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcaaaaaaga gggttcttga acctctgggc ctggttgagg agcctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggca accagcctgc aagaaagaga ttgaatttcg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgatgg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggctctgccc acctacaaca accatctgta caagcagatt      780

tccagccaat caggagccag caacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcaacttca agctctttaa cattcaagtc      960

agagaggtca cgcagaatga tggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta cttcccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cctttgagga tgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgca gtccaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggatcagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg acaacaacaa cagtgaatac     1500

tcgtggattg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggcaatgg ccagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggaa aacaaggatc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcagaac caccaatccc gtggccacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca tctactgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcctat ctgggcaaag     1860

attccgcaca cggacggaca ttttcacccc tctcccctca tgggcggatt cggacttaaa     1920

caccctcctc cacagattct catcaaaaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtatt ccacggggcg ggtcagcgtg     2040

gagatcgagt gggagctaca gaaggagaac agcaaacgct ggaatcccga gatccagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  303
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  303

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asp His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Asp Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Arg Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Ile Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ser Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Arg Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  304
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  304
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagacag gccagcagcc cgcgaaaaag agactcaact ttgggcagac tggcgactca      540

gagtcagtgc ccgaccctca accaatcgga gaaccccccg caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattccg catggctggg cgacagagtc      720

atcaccacca gcacccgacc ctgggccctc cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcaacttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtctttac ggactcggaa taccagctcc cgtacgtcct cggctctgcg     1080

caccagggct gcccgcctcc gttcccggcg gacgtcttca tgattcctca gtacgggtac     1140

ctgactctga acaacggcag tcaggccgtg ggccgttcct ccttctactg cctggagtac     1200

tttccttctc aaatgcggag aacgggcaac aactttgagt tcagctacca gtttgaggac     1260

gtgccttttc acagcagcta cgcgcatagc caaagcctgg accggctgat gaaccccctc     1320

atcgaccagt acctgtacta cctgtctcgg actcagtcca cgggaggtac cgcaggaact     1380

cagcagttgc tattttctca ggccgggcct aataacatgt cggctcaggc caaaaactgg     1440

ctacccgggc cctgctaccg gcagcaacgc gtctccacga cactgtcgca aaataacaac     1500

agcaactttg cttggaccgg tgccaccaag tatcatctga atggcagaga ctctctggta     1560

aatcccggtg tcgctatggc aacgcacaag gacgacgaag agcgattttt tccatccagc     1620

ggagtcttga tgtttgggaa acagggagct ggaaaagaca acgtggacta tagcagcgtt     1680

atgctaacca gtgaggaaga aatcaaaacc accaacccag tggccacaga acagtacggc     1740

gtggtggccg ataacctgca acagcaaaac gccgctccta ttgtaggggc cgtcaacagt     1800

caaggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatc     1860

tgggccaaga ttcctcacac ggacggcaac tttcatcctt cgccgctgat gggaggcttt     1920

ggactgaaac acccgcctcc tcagatcctg attaagaata cacctgttcc cgcggatcct     1980

ccaactacct tcagtcaagc caagctggcg tcgttcatca cgcagtacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaagagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt caatactgag     2160

ggtacttatt cagagcctcg ccccattggc acccgttacc tcacccgtaa cctgtaa        2217


<210>  305
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  305

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Ala Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Pro Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Pro Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Arg Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  306
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  306

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Val Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Thr Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Asn Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Thr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  307
<211>  3158
<212>  DNA
<213>  Adeno-associated virus

<400>  307
gattgaattt agcggccgcg aattcgccct tgctgcgtca actggaccaa tgagaacttt       60

cctttcaatg attgcgtcga caagatggtg atctggtggg aggagggaaa gatgaccgcc      120

aaggtcgtgg agtcggccaa agccattctc ggaggaagca aggtgcgcgc ggaccagaaa      180

tgcaagtcct cggcccagat agacccgact cccgtgattg tcacctccaa caccaacatg      240

tgcgccgtga ttgacgggaa ctcaacgacc ttcgaacacc agcagccgtt gcaagaccgg      300

atgttcaaat ttgaactcac ccgccgtctg gatcatgact ttgggaaggt caccaagcag      360

gaagtcaaag actttttccg gtgggcaaag gatcacgtgg ttgaggtgga gcatgaattc      420

tacgtcaaaa agggtggagc taagaaaaga cccgccccca gtgacgcaga tataagtgag      480

cccaaacggg cgcgcgagtc agttgcgcag ccatcgacgt cagacgcgga agcttcgatc      540

aactacgcgg gcaggtacca aaacaaatgt tctcgtcacg tgggcatgaa tctgatgctg      600

tttccctgca gacaatgcga gagaatgaat cagaattcaa atatctgctt cactcacgga      660

cagaaagact gtttagagtg ctttcccgtg tcagaatctc aacccgtttc tgtcgtcaaa      720

aaggcgtatc agaaactttg ctacattcat catatcatgg gaaaggtgcc agacgcttgc      780

actgcctgcg atctggtcaa tgtggatttg gatgactgca tctctgaaca ataaatgatt      840

taaatcaggt atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga      900

aggaataaga cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg      960

gcataaggac gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa     1020

cggactcgac aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa     1080

ggcctacgac cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga     1140

cgcggagttt caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc     1200

agtcttccag gcaaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa     1260

aacggctccg ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc     1320

gggaaccgga aaagcgggcc agcagcctgc aagaaaaaga ttgaatttcg gtcagactgg     1380

agacgcagac tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg     1440

tctgggatct actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg     1500

tgccgatgga gtgggtaatt cctcgggaaa ttggcattgc gattcccaat ggctgggcga     1560

cagagtcatc accaccagca cccgcacctg ggccctgccc acctacaaca accacctcta     1620

caagcaaatc tccagccaat caggagcctc aaacgacaac cactactttg gctacagcac     1680

cccctggggg tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca     1740

aagactcatc aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa     1800

cattcaagtc aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac     1860

cagcacggtt caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc     1920

gcatcaagga tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata     1980

cctcaccctg aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta     2040

ctttccttct cagatgctgc gtaccggaaa caactttcaa ttcagctaca cttttgaaga     2100

cgtgcctttc cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct     2160

ggtcgaccag tacctgtatt atctgaacaa gacacaaaca aatagtggaa ctcttcagca     2220

gtctcggcta ctgtttagcc aagctggacc caccaacatg tctcttcaag ctaaaaactg     2280

gctgcctgga ccttgctaca gacagcagcg tctgtcaaag caggcaaacg acaacaacaa     2340

cagcaacttt ccctggactg cagctacaaa gtatcatcta aatggccggg actcgttggt     2400

taatccagga ccagctatgg ccagtcacaa ggatgacgaa gaaaagtttt tccccatgca     2460

tggaaccctt atatttggta aacaaggaac aaatgccaac gacgcggatt tggaaaatgt     2520

catgattaca gatgaagaag aaatcaggac caccaatccc gtggctacgg agcagtacgg     2580

aactgtatca aataatttgc aaaactcaaa cactggtcca actactggaa ctgtcaatca     2640

ccaaggagcg ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat     2700

ttgggccaag attcctcaca ccgatggaca ctttcatcct tctccactga tgggaggttt     2760

tggactcaaa cacccacctc ctcaaatcat gatcaaaaac actcccgttc cagccaatcc     2820

tcccacaaac ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacggggca     2880

ggtcagcgtg gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga     2940

aattcagtac acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa     3000

tggtgtgtat tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaatt     3060

gcttgttaat caataaaccg tttaattcgt ttcagttgaa ctttggtctc tgcgaagggc     3120

gaattcgttt aaacctgcag gactagtccc tttagtga                             3158


<210>  308
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  308

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Pro Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Thr Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Asn Met Ser Leu Gln Ala Lys Asn Arg Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Thr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Val Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  309
<211>  3159
<212>  DNA
<213>  Adeno-associated virus

<400>  309
gattgaattt agcggccgcg aattcgccct tgctgcgtca actggaccaa tgagaacttt       60

cctttcaatg attgcgtcga caagatggtg atctggtggg aggagggaaa gatgaccgcc      120

aaggtcgtgg agtcggccaa agccattctc ggaggaagca aggtgcgcgt ggaccagaaa      180

tgcaagtcct cggcccagat agacccgact cccgtgattg tcacctccaa caccgacatg      240

tgcgccgtga ttgacgggaa ctcaacgacc ttcgaacacc agcagccgtt gcaagaccgg      300

atgttcaaat ttgaactcac ccgccgtctg gatcatgact ttgggaaggt caccaagcag      360

gaagtcaaag actttttccg gtgggcaaag gatcacgtgg ttgaggtgga gcatgaattc      420

tacgtcaaaa agggtggagc taagaaaaga cccgccccca gtgacgcaga tataagtgag      480

cccaaacggg cgcgcgagtc agttgcgcag ccatcgacgt cagacgcgga agcttcgatc      540

aactacgcgg acaggtacca aaacaaatgt tctcgtcacg tgggcatgaa tctgatgctg      600

tttccctgca gacaatgcga gagaatgaat cagaattcaa atatctgctt cactcacgga      660

cagaaagact gtttagagtg ctttcccgtg tcagaatctc aacccgtttc tgtcgtcaaa      720

aaggcgtatc agaaactttg ctacattcat catatcatgg gaaaggtgcc agacgcttgc      780

actgcctgcg atctggtcaa tgtggatttg gatgactgca tctctgaaca ataaatgatt      840

taaatcaggt atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga      900

aggaataaga cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg      960

gcataaggac gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa     1020

cggactcgac aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa     1080

ggcctacgac cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga     1140

cgcggagttt caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc     1200

agtcttccag gcaaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa     1260

aacggctccg ggaaaaaaga ggccggtaga gcaccctcct gtggagccag actcctcctc     1320

gggaaccgga aaagcgggcc agcagcctgc aagaaaaaga ttgaatttcg gtcagactgg     1380

agacgcagac tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg     1440

tctgggatct actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg     1500

tgccgatgga gtgggtaatt cctcgggaaa ttggcattgc gattcccaat ggctgggcga     1560

cagagtcatc accaccagca cccgcacctg ggccctgccc acctacaaca accacctcta     1620

caagcaaatc tccagccaat caggagcctc aaacgacaac cactactttg gctacagcac     1680

cccctggggg tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca     1740

aagactcatc aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa     1800

cattcaagtc aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac     1860

cagcacggtt caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc     1920

gcatcaagga tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata     1980

cctcaccctg aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta     2040

ctttccttct cagatgctgc gtaccggaaa caactttcag ttcagctaca cttttgaaga     2100

cgtgcctttc cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct     2160

gatcgaccag tacctgtatt atctgaacaa gacacaaaca aatagtggaa ctcttcagca     2220

gtctcggcta ctgtttagcc aagctggacc caccaacatg tctcttcaag ctaaaaaccg     2280

gctgcctgga ccttgctaca gacagcagcg tctgtcaaag caggcaaacg acaacaacaa     2340

cagcaacttt ccctggaccg cagctacaaa gtatcatcta aatggccggg actcgttggt     2400

taatccagga ccagctatgg ccagtcacaa ggatgacgaa gaaaagtttt tccccatgca     2460

tggaaccctt atatttggta aacaaggaac aaatgccaac gacgcggatt tggaaaatgt     2520

catgattaca gatgaagaag aaatcaggac caccaatccc gtggctacgg agcagtacgg     2580

aactgtatca aataatttgc aaaactcaaa cactggtcca actactggaa ctgtcaatca     2640

ccaaggagcg ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat     2700

ttgggccaag attcctcaca ccgatggaca ctttcatcct tctccactgg tgggaggttt     2760

tggactcaaa cacccacctc ctcaaatcat gatcaaaaac actcccgttc cagccaatcc     2820

tcccacaaac ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacggggca     2880

ggtcagcgtg gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga     2940

aattcagtac acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa     3000

tggtgtgtat tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaatt     3060

gcttgttaat caataaaccg tttaattcgt ttcagttgaa ctttggtctc tgcgaagggc     3120

gaattcgttt aaacctgcag gactagtccc tttagtgag                            3159


<210>  310
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  310
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtaccttg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac cccaagtaca accacgccga cgcggagttc      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaatttcg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgcacctg ggctctgccc acctacaaca accacctcta caagcagatt      780

tccagccaat caggagcctc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcgccac gtgactggca aagactcatc      900

aacaacaatt ggggattccg gcccaaaaga ctcaacttca agctctttaa cattcaagtc      960

aaggaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgcccacag ccagagtttg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctt aatggaagag actctctggt gaatccgggc     1560

ccggccatgg ccagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtgtggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt cggacttaaa     1920

caccctcccc cgcagattct catcaagaac accccggtac ctgcgaatcc ttcgactacc     1980

ttcagtgcgg caaagtttgc ttccttcatt acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga gattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccaggtac ctgactcgta atctgtaa                  2208


<210>  311
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  311

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Pro Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  312
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  312
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtaccttg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acggcggaga caacccgtac ctcaagtaca accacgccga cgcggagttc      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctctt gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaggaga ttgaatttcg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgcacctg ggctctgccc acctacaaca accacctcta caggcagatt      780

tccagccaat caggagcctc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcgccac gtgactggca aagactcatc      900

aacaacaatt ggggatcccg gcccaaaaga ctcaacttca agctctttaa cattcaagtc      960

aaggaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgcccacag ccagagtttg gaccgtctca tgaatcctct cgtcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctt aatggaagag actctctggt gaatccgggc     1560

ccggccatgg ccagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtgtggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt cggacttaaa     1920

caccctcccc cgcagattct catcaagaac accccggtac ctgcgaatcc ttcgactacc     1980

ttcagtgcgg caaagtttgc ttccttcatt acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga gattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  313
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  313

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Gly Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Leu Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Arg Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Arg Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Ser Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Val Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  314
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  314

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Ala Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Glu Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Cys Ala His Ser Gln Ser 
            420                 425                 430         


Ser Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Arg Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  315
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  315
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcttggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaatgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattttgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcggcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccgtcgagt     1620

ggagtcctga tgtttggaaa acagggtgct ggaagagaca atgtggacta cagcagcgtt     1680

atgctaacca gcgaagaaga aattaaaacc actaaccctg tagccacaga acaatacggt     1740

gtggtggctg acaacttgca gcaaaccaat acagggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccaccctt caccgctaat gggaggattt     1920

ggactgaagc acccacctcc tcagatcctg atcaagaaca cgccggtacc tgcggatcct     1980

ccaacgacgt tcagccaggc gaaattggct tccttcatta cgcagtacag caccggacag     2040

gtcagcgtgg aaatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaacccagag     2100

attcagtaca cttcaaacta ctacaaatct acaaatgtgg actttgctgt caatacagag     2160

ggaacttatt ctgagcctcg ccccattggt actcgttacc tcacccgtaa tctgtaa        2217


<210>  316
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  316

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Leu 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Gly Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  317
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  317

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Pro Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Asp Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  318
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  318

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Gly Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Asp Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  319
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  319
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg gacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tttgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tcaagccaat caggagcctc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcgggtcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gtactggaaa caactttcag ttcagctaca cctttgaaga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa aacacaatca aatagtggaa ctcttcagca gtctcggcta     1380

ctgtttagtc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctacctgga     1440

ccttgctaca gacagcagcg tctgtcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtatcaccta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagtcacaa agacgatgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggacaatgt catgattaca     1680

gatgaagaag aaatccgcac caccaatccc gtggctacgg agcagtacgg atatgtgtca     1740

aataatttgc aaaactcaaa tactggtcca actactggaa ctgtcaatca ccaaggagcg     1800

ttacctggca tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactga tgggaggttt tgggctcaaa     1920

cacccgcctc ctcagatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaagagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  320
<211>  2211
<212>  DNA
<213>  Adeno-associated virus

<400>  320
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg atccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

caatacctgt attacctgaa cagaactcaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210>  321
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  321
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaacaaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tttgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tcaagccaat caggagcctc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcgggtcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gtactggaaa caactttcag ttcagctaca cctttgaaga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa aacacaatca aatagtggaa ctcttcagca gtctcggcta     1380

ctgtttagtc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctacctgga     1440

ccttgctaca gacagcagcg tctgtcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtaccaccta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagtcacaa agacgatgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggacaatgt catgattaca     1680

gatgaagaag aaatccgcac caccaatccc gtggctacgg agcagtacgg atatgtgtca     1740

aataatttgc aaaactcaaa tactggtcca actactggaa ctgtcaatca ccaaggagcg     1800

ttacctggca tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactga tgggaggttt tgggctcaaa     1920

cacccgcctc ctcagatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaagagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  322
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  322
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccacctg caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg agggagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattttgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccgtcgagt     1620

ggagtcctga tgtttggaaa acagggtgct ggaagagaca atgtggacta cagcagcgtt     1680

atgctaacca gcgaagaaga aattaaaacc actaaccctg tagccacaga acaatacggt     1740

gtggtggctg acaacttgca gcaaaccaat acagggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac tgccaccctt caccgctaat gggaggattt     1920

ggactgaagc acccacctcc tcagatcctg atcaagaaca cgccggtacc tgcggatcct     1980

ccaacaacgt tcagccaggc gaaattggct tccttcatta cgcagtacag caccggacag     2040

gtcagcgtgg aaatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaacccagag     2100

attcagtaca cttcaaacta ctacaaatct acaaatgtgg actttgctgt caatacagag     2160

ggaacttatt ctgagcctcg ccccattggt actcgttacc tcacccgtaa tctgtaa        2217


<210>  323
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  323

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Thr Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Asp Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  324
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  324
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcatcaggac      120

aacagcaggg gtcttgtgct tcctgggtac aagtacctcg gaccctccaa cggactcgac      180

aaaggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggcc atcagcctgc gagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag cccccacaag tttgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tccagccaat caggagcctc gaacgacaac cactactttg gctgcagcac cccctggggg      840

tattttgact tcaacagatt ccactgtcac ttctccccac gtgattggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtacccgctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccggctga tgaatcctct gatcgaccag     1320

tatctatatt atctgaacag gacacaatca aatagtggaa ctcttcagca gtctaggcta     1380

ctgtttagcc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctttcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagccacaa agacgatgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggagcatgt tatgattaca     1680

gatgaagaag aaatcaggac caccaatcct gtggctacag agcagtacgg aaacgtgtca     1740

aataatttgc aaaactcaaa tactggtcca actacagaaa atgtcaatca ccagggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgacggaca ctttcaccct tctccactga tgggaggttt tggactcaaa     1920

cacccgcctc ctcaaatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggcca ggtcagcgtg     2040

gagattgagt gggagctgca gaaggagaac agcaaacgct ggaaccccga gatccagtat     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctt gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  325
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  325

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Gln Asp Asn Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Ser Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Cys Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Pro Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu His Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Asn Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Glu Asn Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Cys Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  326
<211>  2214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  326
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc ttggcagagc agtcttccag      360

gccaaaaaga ggatccttga gcctcttggt ctggttgagg aagcagctaa aacggctcct      420

ggaaagaaga ggcctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatggg      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacggga catcgggagg agccaccaac gacaacacct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagagactca gcttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcgcac     1080

cagggctgcc tccctccgtt cccggcggac gtgttcatga ttccgcaata cggctacctg     1140

acgctcaaca atggcagcca agccgtggga cgttcatcct tttactgcct ggaatatttc     1200

ccttctcaga tgctgagaac gggcaacaac tttaccttca gctacacctt tgaggaagtg     1260

cctttccaca gcagctacgc gcacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacggc aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca acaacgcgtc tcaacgacaa ccgggcaaaa caacaatagc     1500

aactttgcct ggactgctgg gaccaaatac catctgaatg gaagaaattc attggctaat     1560

cctggcatcg ctatggcaac acacaaagac gacgaggagc gtttttttcc cagtaacggg     1620

atcctgattt ttggcaaaca aaatgctgcc agagacaatg cggattacag cgatgtcatg     1680

ctcaccagcg aggaagaaat caaaaccact aaccctgtgg ctacagagga atacggtatc     1740

gtggcagata acttgcagca gcaaaacacg gctcctcaaa ttggaactgt caacagccag     1800

ggggccttac ccggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttc cacccgtctc cgctgatggg cggctttggc     1920

ctgaaacatc ctccgcctca gatcctgatc aagaacacgc ctgtacctgc ggatcctccg     1980

accaccttca accagtcaaa gctgaactct ttcatcacgc aatacagcac cggacaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gaaaacagca agcgctggaa cccggagatc     2100

cagtacactt ccaactatta caagtctaat aatgttgaat ttgctgttaa tactgaaggt     2160

gtatatagtg aaccccgccc cattggcacc agatacctga ctcgtaatct gtaa           2214


<210>  327
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  327

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr His 
        515                 520                 525             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met 
545                 550                 555                 560 


Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro 
            580                 585                 590         


Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  328
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  328
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc catttctcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ctgccgtacg ttctcggctc tgcccaccag     1080

ggctgcctgc ctccgttccc ggcggacgtg ttcatgattc cccagtacgg ctacctaaca     1140

ctcaacaacg gtagtcaggc cgtgggacgc tcctccttct actgcctgga atactttcct     1200

tcgcagatgc tgagaaccgg caacaacttc cagtttactt acaccttcga ggacgtgcct     1260

ttccacagca gctacgccca cagccagagc ttggaccggc tgatgaatcc tctgattgac     1320

cagtacctgt actacttgtc tcggactcaa acaacaggag gcacggcaaa tacgcagact     1380

ctgggcttca gccaaggtgg gcctaataca atggccaatc aggcaaagaa ctggctgcca     1440

ggaccctgtt accgccaaca acgcgtctca acgacaaccg ggcaaaacaa caatagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210>  329
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  329

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg 
        435                 440                 445             


Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe Ser 
    450                 455                 460                 


Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  330
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  330
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcga       60

gagtggtggg cgctgcaacc tggagcccct aaacccaagg caaatcaaca acatcaggac      120

aacgctcggg gtcttgtgct tccgggttac aaatacctcg gacccggcaa cggactcgac      180

aagggggaac ccgtcaacgc agcggacgcg gcagccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggtga caacccctac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca ccagaacctg ggccctgccc acttacaaca accatctcta caagcaaatc      780

tccagccaat caggagcttc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact ttaacagatt ccactgccac ttctcaccac gtgactggca gcgactcatt      900

aacaacaact ggggattccg gcccaagaaa ctcagcttca agctcttcaa catccaagtt      960

aaagaggtca cgcagaacga tggcacgacg actattgcca ataaccttac cagcacggtt     1020

caagtgttta cggactcgga gtatcagctc ccgtacgtgc tcgggtcggc gcaccaaggc     1080

tgtctcccgc cgtttccagc ggacgtcttc atggtccctc agtatggata cctcaccctg     1140

aacaacggaa gtcaagcggt gggacgctca tccttttact gcctggagta cttcccttcg     1200

cagatgctaa ggactggaaa taacttccaa ttcagctata ccttcgagga tgtacctttt     1260

cacagcagct acgctcacag ccagagtttg gatcgcttga tgaatcctct tattgatcag     1320

tatctgtact acctgaacag aacgcaagga acaacctctg gaacaaccaa ccaatcacgg     1380

ctgcttttta gccaggctgg gcctcagtct atgtctttgc aggccagaaa ttggctacct     1440

gggccctgct accggcaaca gagactttca aagactgcta acgacaacaa caacagtaac     1500

tttccttgga cagcggccag caaatatcat ctcaatggcc gcgactcgct ggtgaatcca     1560

ggaccagcta tggccagtca caaggacgat gaagaaaaat ttttccctat gcacggcaat     1620

ctaatatttg gcaaagaagg gacaacggca agtaacgcag aattagataa tgtaatgatt     1680

acggatgaag aagagattcg taccaccaat cctgtggcaa cagagcagta tggaactgtg     1740

gcaaataact tgcagagctc aaatacagct cccacgacta gaactgtcaa tgatcagggg     1800

gccttacctg gcatggtgtg gcaagatcgt gacgtgtacc ttcaaggacc tatctgggca     1860

aagattcctc acacggatgg acactttcat ccttctcctc tgatgggagg ctttggactg     1920

aaacatccgc ctcctcaaat catgatcaaa aatactccgg taccggcaaa tcctccgacg     1980

actttcagcc cggccaagtt tgcttcattt atcactcagt actccactgg acaggtcagc     2040

gtggaaattg agtgggagct acagaaagaa aacagcaaac gttggaatcc agagattcag     2100

tacacttcca actacaacaa gtctgttaat gtggacttta ctgtagacac taatggtgtt     2160

tatagtgaac ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210>  331
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  331

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  332
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  332
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgctaaaaag agactcaatt ttggtcagac tggcgactca      540

gagtcagtcc ccgacccaca acctctcgga gaacctccag caacccccgc tgctgtggga      600

cctactacaa tggcttcagg cggtggcgca ccaatggcag acaataacga gggtgccgat      660

ggagtgggta attcctcagg aaattggcat tgcgattccc aatggctggg cgacagagtc      720

atcaccacca gcaccagaac ctgggccctg cccacttaca acaaccatct ctacaagcaa      780

atctccagcc aatcaggagc ttcaaacgac aaccactact ttggctacag caccccttgg      840

gggtattttg actttaacag attccactgc cacttttcac cacgtgactg gcaaagactc      900

atcaacaaca actggggatt ccgacccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacttttga ggacgttcct     1260

ttccacagca gctacgctca cagccagagt ctggaccgtc tcatgaatcc tctcatcgac     1320

cagtacctgt attacttgag cagaacaaac actccaagtg gaaccaccac gcagtcaagg     1380

cttcagtttt ctcaggccgg agcgagtgac attcgggacc agtctaggaa ctggcttcct     1440

ggaccctgtt accgccagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacggatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210>  333
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  333

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg 
        435                 440                 445             


Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser 
    450                 455                 460                 


Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  334
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  334
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagcccct aaacccaagg caaatcaaca acatcaggac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgctaaaaag agactcaatt ttggtcagac tggcgactca      540

gagtcagtcc ccgacccaca acctctcgga gaacctccag caacccccgc tgctgtggga      600

cctactacaa tggcttcagg cggtggcgca ccaatggcag acaataacga gggtgccgat      660

ggagtgggta attcctcagg aaattggcat tgcgattccc aatggctggg cgacagagtc      720

atcaccacca gcaccagaac ctgggccctg cccacttaca acaaccatct ctacaagcaa      780

atctccagcc aatcaggagc ttcaaacgac aaccactact ttggctacag caccccttgg      840

gggtattttg actttaacag attccactgc cacttttcac cacgtgactg gcaaagactc      900

atcaacaaca actggggatt ccgacccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacttttga ggacgttcct     1260

ttccacagca gctacgctca cagccagagt ctggaccgtc tcatgaatcc cctcatcgac     1320

cagtacctgt attacttgag cagaacaaac actccaagtg gaaccaccac gcagtcaagg     1380

cttcagtttt ctcaggccgg agcgagtgac attcgggacc agtctaggaa ctggcttcct     1440

ggaccctgtt accggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtgtacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacggatgg acactttcac ccgtctcctc tcatgggcgg ctttggactt     1920

aagcacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggca     1980

gagttttcgg ctacaaagtt tgcttcattc atcacccagt attccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210>  335
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  335

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg 
        435                 440                 445             


Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser 
    450                 455                 460                 


Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  336
<211>  2214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  336
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc ttggcagagc agtcttccag      360

gccaaaaaga ggatccttga gcctcttggt ctggttgagg aagcagctaa aacggctcct      420

ggaaagaaga ggcctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatggg      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat gactggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacggga catcgggagg agccaccaac gacaacacct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagagactca gcttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcgcac     1080

cagggctgcc tccctccgtt cccggcggac gtgttcatga ttccgcaata cggctacctg     1140

acgctcaaca atggcagcca agccgtggga cgttcatcct tttactgcct ggaatatttc     1200

ccttctcaga tgctgagaac gggcaacaac tttaccttca gctacacctt tgaggaagtg     1260

cctttccaca gcagctacgc gcacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacggc aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca acaacgcgtc tcaacgacaa ccgggcaaaa caacaatagc     1500

aactttgcct ggactgctgg gaccaaatac catctgaatg gaagaaattc attggctaat     1560

cctggcatcg ctatggcaac acacaaagac gacgaggagc gtttttttcc cagtaacggg     1620

atcctgattt ttggcaaaca aaatgctgcc agagacaatg cggattacag cgatgtcatg     1680

ctcaccagcg aggaagaaat caaaaccact aaccctgtgg ctacagagga atacggtatc     1740

gtggcagata acttgcagca gcaaaacacg gctcctcaaa ttggaactgt caacagccag     1800

ggggccttac ccggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttc cacccgtctc cgctgatggg cggctttggc     1920

ctgaaacatc ctccgcctca gatcctgatc aagaacacgc ctgtacctgc ggatcctccg     1980

accaccttca accagtcaaa gctgaactct ttcatcacgc aatacagcac cggacaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gaaaacagca agcgctggaa cccggagatc     2100

cagtacactt ccaactatta caagtctaat aatgttgaat ttgctgttaa tactgaaggt     2160

gtatatagtg aaccccgccc cattggcacc agatacctga ctcgtaatct gtaa           2214


<210>  337
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  337

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Leu Gly Asp Arg Val Ile Thr 
225                 230                 235                 240 


Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr 
                245                 250                 255     


Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp Asn Thr 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg 
        435                 440                 445             


Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe Ser 
    450                 455                 460                 


Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr His Lys 
        515                 520                 525             


Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met Leu 
545                 550                 555                 560 


Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro Gln 
            580                 585                 590         


Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  338
<211>  2214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  338
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc ttggcagagc agtcttccag      360

gccaaaaaga ggatccttga gcctcttggt ctggttgagg aagcagctaa aacggctcct      420

ggaaagaaga ggcctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatggg      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacggga catcgggagg agccaccaac gacaacacct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagagactca gcttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcgcac     1080

cagggctgcc tccctccgtt cccggcggac gtgttcatga ttccgcaata cggctacctg     1140

acgctcaaca atggcagcca agccgtggga cgttcatcct tttactgcct ggaatatttc     1200

ccttctcaga tgctgagaac gggcaacaac tttaccttca gctacacctt tgaggaagtg     1260

ccttttcaca gcagctacgc gcacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacggc aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca acaacgcgtc tcaacgacaa ccgggcaaaa caacaatagc     1500

aactttgcct ggactgctgg gaccaaatac catctgaatg gaagaaattc attggctaat     1560

cctggcatcg ctatggcaac acacaaagac gacgaggagc gtttttttcc cagtaacggg     1620

atcctgattt ttggcaaaca aaatgctgcc agagacaatg cggattacag cgatgtcatg     1680

ctcaccagcg aggaagaaat caaaaccact aaccctgtgg ctacagagga atacggtatc     1740

gtggcagata acttgcagca gcaaaacacg gctcctcaaa ttggaactgt caacagccag     1800

ggggccttac ccggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttc cacccgtctc cgctgatggg cggctttggc     1920

ctgaaacatc ctccgcctca gatcctgatc aagaacacgc ctgtacctgc ggatcctccg     1980

accaccttca accagtcaaa gctgaactct ttcatcacgc aatacagcac cggacaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gaaaacagca agcgctggaa cccggagatc     2100

cagtacactt ccaactatta caagtctaat aatgttgaat ttgctgttaa tactgaaggt     2160

gtatatagtg aaccccgccc cattggcacc agatacctga ctcgtaatct gtaa           2214


<210>  339
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  339

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr His 
        515                 520                 525             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met 
545                 550                 555                 560 


Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro 
            580                 585                 590         


Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  340
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  340
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagcccct aaacccaagg caaatcaaca acatcaggac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgctaaaaag agactcaatt ttggtcagac tggcgactca      540

gagtcagtcc ccgacccaca acctctcgga gaacctccag caacccccgc tgctgtggga      600

cctactacaa tggcttcagg cggtggcgca ccaatggcag acaataacga gggtgccgat      660

ggagtgggta attcctcagg aaattggcat tgcgattccc aatggctggg cgacagagtc      720

atcaccacca gcaccagaac ctgggccctg cccacttaca acaaccatct ctacaagcaa      780

atctccagcc aatcaggagc ttcaaacgac aaccactact ttggctacag caccccttgg      840

gggtattttg actttaacag attccactgc cacttttcac cacgtgactg gcaaagactc      900

atcaacaaca actggggatt ccgacccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacttttga ggacgttcct     1260

ttccacagca gctacgctca cagccagagt ctggaccgtc tcatgaatcc tctcatcgac     1320

cagtacctgt attacttgag cagaacaaac actccaagtg gaaccaccac gcagtcaagg     1380

cttcagtttt ctcaggccgg agcgagtgac attcgggacc agtctaggaa ctggcttcct     1440

ggaccctgtt accgccagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210>  341
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  341

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg 
        435                 440                 445             


Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser 
    450                 455                 460                 


Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  342
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  342
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tccgggttac aaatacctcg gacccggtaa cggactcgac      180

aaaggagagc cggtcaacga ggcggacgcg gcagccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctccc      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctctac gggcatcggc      480

aagaaaggcc aacagcccgc cagaaaaaga ctcaatttcg gtcagactgg cgactcagag      540

tcagttccag accctcaacc tctcggagaa cctccagcag cgccctctgg tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aacacctact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc catttctcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaggc agtgggacgg tcatcctttt actgcctgga atatttccca     1200

tcgcagatgc tgagaacggg caataacttt accttcagct acaccttcga ggacgtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgggggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggca     1980

gagttttcgg ctacaaagtt tgcttcattc atcacccagt attccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210>  343
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  343

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Thr Gly Ile Gly 
145                 150                 155                 160 


Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn Thr 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  344
<211>  2205
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  344
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcgt       60

gagtggtggg ctctgaaacc tggagtccct caacccaaag cgaaccaaca acaccaggac      120

aaccgtcggg gtcttgtgct tccgggttac aaatacctcg gacccggtaa cggactcgac      180

aaaggagagc cggtcaacga ggcggacgcg gcagccctcg aacacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca gcgactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctcttcaa catccaggtc      960

aaagaggtta cggacaacaa tggagtcaag accatcgcca ataaccttac cagcacggtc     1020

caggtcttca cggactcaga ctatcagctc ccgtacgtgc tcgggtcggc tcacgagggc     1080

tgcctcccgc cgttcccagc ggacgttttc atgattcctc agtacgggta tctgacgctt     1140

aatgatggaa gccaggccgt gggtcgttcg tccttttact gcctggaata tttcccgtcg     1200

caaatgctaa gaacgggtaa caacttccag ttcagctacg agtttgagaa cgtacctttc     1260

catagcagct acgctcacag ccaaagcctg gaccgactaa tgaatccact catcgaccaa     1320

tacttgtact atctctcaaa gactattaac ggttctggac agaatcaaca aacgctaaaa     1380

ttcagtgtgg ccggacccag caacatggct gtccagggaa gaaactacat acctggaccc     1440

agctaccgac aacaacgtgt ctcaaccact gtgactcaaa acaacaacag cgaatttgct     1500

tggcctggag cttcttcttg ggctctcaat ggacgtaata gcttgatgaa tcctggacct     1560

gctatggcca gccacaaaga aggagaggac cgtttctttc ctttgtctgg atctttaatt     1620

tttggcaaac aaggaactgg aagagacaac gtggatgcgg acaaagtcat gataaccaac     1680

gaagaagaaa ttaaaactac taacccggta gcaacggagt cctatggaca agtggccaca     1740

aaccaccaga gtgcccaagc acaggcgcag accggctggg ttcaaaacca aggaatactt     1800

ccgggtatgg tttggcagga cagagatgtg tacctgcaag gacccatctg ggccaagatt     1860

cctcacacgg acggcaactt ccacccgtct ccgctgatgg gcggctttgg cctgaaacat     1920

cctccgcctc agatcctgat caagaacacg cctgtacctg cggatcctcc gaccaccttc     1980

aaccagtcaa agctgaactc tttcatcacg caatacagca ccggacaggt cagcgtggaa     2040

attgaatggg agctgcagaa ggaaaacagc aagcgctgga atcccgaagt gcagtataca     2100

tctaactatg caaaatctgc caacgttgat ttcactgtgg acaacaatgg actttatact     2160

gagcctcgcc ccattggcac ccgttacctc acccgtcccc tgtaa                     2205


<210>  345
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  345

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu Phe Glu 
                405                 410                 415     


Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser Val Ala 
    450                 455                 460                 


Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro Gly Pro 
465                 470                 475                 480 


Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn Asn Asn 
                485                 490                 495     


Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn Gly Arg 
            500                 505                 510         


Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys Glu Gly 
        515                 520                 525             


Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly Lys Gln 
    530                 535                 540                 


Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile Thr Asn 
545                 550                 555                 560 


Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser Tyr Gly 
                565                 570                 575     


Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln Thr Gly 
            580                 585                 590         


Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp Arg 
        595                 600                 605             


Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro 
                645                 650                 655     


Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu 
        675                 680                 685             


Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn Tyr Ala 
    690                 695                 700                 


Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu Tyr Thr 
705                 710                 715                 720 


Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 


<210>  346
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  346
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagt gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc catttctcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

caatacctgt attacctgaa cagaactcaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

accgacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210>  347
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  347

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Trp Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  348
<211>  2214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  348
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc ttggcagagc agtcttccag      360

gccaaaaaga ggatccttga gcctcttggt ctggttgagg aagcagctaa aacggctcct      420

ggaaagaaga ggcctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatggg      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacggga catcgggagg agccaccaac gacaacacct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagagactca gcttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctcggcgcac     1080

cagggctgcc tccctccgtt cccggcggac gtcttcatgg tgccacagta tggatacctg     1140

acgctcaaca atggcagcca agccgtggga cgttcatcct tttactgcct ggaatatttc     1200

ccttctcaga tgctgagaac gggcaacaac tttaccttca gctacacctt tgaggaagtg     1260

cctttccaca gcagctacgc gcacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacggc aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca acaacgcgtc tcaacgacaa ccgggcaaaa caacaatagc     1500

aactttgcct ggactgctgg gaccaaatac catctgaatg gaagaaattc attggctaat     1560

cctggcatcg ctatggcaac acacaaagac gacgaggagc gtttttttcc cagtaacggg     1620

atcctgattt ttggcaaaca aaatgctgcc agagacaatg cggattacag cgatgtcatg     1680

ctcaccagcg aggaagaaat caaaaccact aaccctgtgg ctacagagga atacggtatc     1740

gtggcagata acttgcagca gcaaaacacg gctcctcaaa ttggaactgt caacagccag     1800

ggggacttac ccggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttc cacccgtctc cgctgatggg cggctttggc     1920

ctgaaacatc ctccgcctca gatcctgatc aagaacacgc ctgtacctgc ggatcctccg     1980

accaccttca accagtcaaa gctgaactct ttcatcacgc aatacagcac cggacaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gaaaacagca agcgctggaa cccggagatc     2100

cagtacactt ccaactatta caagtctaat aatgttgaat ttgctgttaa tactgaaggt     2160

gtatatagtg aaccccgccc cattggcacc agatacctga ctcgtaatct gtaa           2214


<210>  349
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  349

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr His 
        515                 520                 525             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met 
545                 550                 555                 560 


Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro 
            580                 585                 590         


Gln Ile Gly Thr Val Asn Ser Gln Gly Asp Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  350
<211>  2205
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  350
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcgt       60

gagtggtggg ctctgaaacc tggagtccct caacccaaag cgaaccaaca acaccaggac      120

aactgtcggg gtcttgtgct tccgggttac aaatacctcg gacccggtaa cggactcgac      180

aaaggagagc cggtcaacga ggcggacgcg gcagccctcg aacacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

accaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca gcgactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctcttcaa catccaggtc      960

aaagaggtta cggacaacaa tggagtcaag accatcgcca ataaccttac cagcacggtc     1020

caggtcttca cggactcaga ctatcagctc ccgtacgtgc tcgggtcggc tcacgagggc     1080

tgcctcccgc cgttcccagc ggacgttttc atgattcctc agtacgggta tctgacgctt     1140

aatgatggaa gccaggccgt gggtcgttcg tccttttact gcctggaata tttcccgtcg     1200

caaatgctaa gaacgggtaa caacttccag ttcagctacg agtttgagaa cgtacctttc     1260

catagcagct acgctcacag ccaaagcctg gaccgactaa tgaatccact catcgaccaa     1320

tacttgtact atctctcaaa gactattaac ggttctggac agaatcaaca aacgctaaaa     1380

ttcagtgtgg ccggacccag caacatggct gtccagggaa gaaactacat acctggaccc     1440

agctaccgac aacaacgtgt ctcaaccact gtgactcaaa acaacaacag cgaatttgct     1500

tggcctggag cttcttcttg ggctctcaat ggacgtaata gcttgatgaa tcctggacct     1560

gctatggcca gccacaaaga aggagaggac cgtttctttc ctttgtctgg atctttaatt     1620

tttggcaaac aaggaactgg aagagacaac gtggatgcgg acaaagtcat gataaccaac     1680

gaagaagaaa ttaaaactac taacccggta gcaacggagt cctatggaca agtggccaca     1740

aaccaccaga gtgcccaagc acaggcgcag accggctggg ttcaaaacca aggaatactt     1800

ccgggtatgg tttggcagga cagagatgtg tacctgcaag gacccatctg ggccaagatt     1860

cctcacacgg acggcaactt ccacccgtct ccgctgatgg gcggctttgg cctgaaacat     1920

cctccgcctc agatcctgat caagaacacg cctgttcctg cgaatcctcc ggcggagttt     1980

tcagctacaa agtttgcttc attcatcacc cagtactcca caggacaagt gagtgtggaa     2040

attgaatggg agctgcagaa agaaaacagc aagcgctgga atcccgaagt gcagtacaca     2100

tccaattatg caaaatctgc caacgttgat tttactgtgg acaacaatgg actttatact     2160

gagcctcgcc ccattggcac ccgttacctt accaaacctc tgtaa                     2205


<210>  351
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  351

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Cys Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Thr Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu Phe Glu 
                405                 410                 415     


Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser Val Ala 
    450                 455                 460                 


Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro Gly Pro 
465                 470                 475                 480 


Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn Asn Asn 
                485                 490                 495     


Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn Gly Arg 
            500                 505                 510         


Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys Glu Gly 
        515                 520                 525             


Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly Lys Gln 
    530                 535                 540                 


Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile Thr Asn 
545                 550                 555                 560 


Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser Tyr Gly 
                565                 570                 575     


Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln Thr Gly 
            580                 585                 590         


Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp Arg 
        595                 600                 605             


Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu 
        675                 680                 685             


Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn Tyr Ala 
    690                 695                 700                 


Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu Tyr Thr 
705                 710                 715                 720 


Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Lys Pro Leu 
                725                 730                 


<210>  352
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  352
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagcccct aaacccaagg caaatcaaca acatcaggac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgctaaaaag agactcaatt ttggtcagac tggcgactca      540

gagtcagtcc ccgacccaca acctctcgga gaacctccag caacccccgc tgctgtggga      600

cctactacaa tggcttcagg cggtggcgca ccaatggcag acaataacga gggtgccgat      660

ggagtgggta attcctcagg aaattggcat tgcgattccc aatggctggg cgacagagtc      720

atcaccacca gcaccagaac ctgggccctg cccacttaca acaaccatct ctacaagcaa      780

atctccagcc aatcaggagc ttcaaacgac aaccactact ttggctacag caccccttgg      840

gggtattttg actttaacag attccactgc cacttttcac cacgtgactg gcaaagactc      900

atcaacaaca actggggatt ccgacccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacttttga ggacgttcct     1260

ttccacagca gctacgctca cagccagagt ctggaccgtc tcatgaatcc tctcatcgac     1320

cagtacctgt attacttgag cagaacaaac actccaagtg gaaccaccac gcagtcaagg     1380

cttcagtttt ctcaggccgg agcgagtgac attcgggacc agtctaggaa ctggcttcct     1440

ggaccctgtt accgccagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210>  353
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  353

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg 
        435                 440                 445             


Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser 
    450                 455                 460                 


Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  354
<211>  2214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  354
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc ttggcagagc agtcttccag      360

gccaaaaaga ggatccttga gcctcttggt ctggttgagg aagcagctaa aacggctcct      420

ggaaagaaga ggcctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatggg      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacggga catcgggagg agccaccaac gacaacacct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagagactca gcttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcgcac     1080

cagggctgcc tccctccgtt cccggcggac gtgttcatga ttccgcaata cggctacctg     1140

acgctcaaca atggcagcca agccgtggga cgttcatcct tttactgcct ggaatatttc     1200

ccttctcaga tgctgagaac gggcaacaac tttaccttca gctacacctt tgaggaagtg     1260

cctttccaca gcagctacgc gcacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacggc aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca acaacgcgtc tcaacgacaa ccgggcaaaa caacaatagc     1500

aactttgcct ggactgctgg gaccaaatac catctgaatg gaagaaattc attggctaat     1560

cctggcatcg ctatggcaac acacaaagac gacgaggagc gtttttttcc cagtaacggg     1620

atcctgattt ttggcaaaca aaatgctgcc agagacaatg cggattacag cgatgtcatg     1680

ctcaccagcg aggaagaaat caaaaccact aaccctgtgg ctacagagga atacggtatc     1740

gtggcagata acttgcagca gcaaaacacg gctcctcaaa ttggaactgt caacagccag     1800

ggggccttac ccggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttc cacccgtctc cgctgatggg cggctttggc     1920

ctgaaacatc ctccgcctca gatcctgatc aagaacacgc ctgtacctgc ggatcctccg     1980

accaccttca accagtcaaa gctgaactct ttcatcacgc aatacagcac cggacaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gaaaacagca agcgctggaa cccggagatc     2100

cagtacactt ccaactatta caagtctaat aatgttgaat ttgctgttaa tactgaaggt     2160

gtatatagtg aaccccgccc cattggcacc agatacctga ctcgtaatct gtaa           2214


<210>  355
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  355

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr His 
        515                 520                 525             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met 
545                 550                 555                 560 


Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro 
            580                 585                 590         


Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  356
<211>  2205
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  356
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcgt       60

gagtggtggg ctctgaaacc tggagtccct caacccaaag cgaaccaaca acaccaggac      120

aaccgtcggg gtcttgtgct tccgggttac aaatacctcg gacccggtaa cggactcgac      180

aaaggagagc cggtcaacga ggcggacgcg gcagccctcg aacacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca gcgactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctcttcaa catccaggtc      960

aaagaggtta cggacaacaa tggagtcaag accatcgcca ataaccttac cagcacggtc     1020

caggtcttca cggactcaga ctatcagctc ccgtacgtgc tcgggtcggc tcacgagggc     1080

tgcctcccgc cgttcccagc ggacgttttc atgattcctc agtacgggta tctgacgctt     1140

aatgatggaa gccaggccgt gggtcgttcg tccttttact gcctggaata tttcccgtcg     1200

caaatgctaa gaacgggtaa caacttccag ttcagctacg agtttgagaa cgtacctttc     1260

catagcagct acgctcacag ccaaagcctg gaccgactaa tgaatccact catcgaccaa     1320

tacttgtact atctctcaaa gactattaac ggttctggac agaatcaaca aacgctaaaa     1380

ttcagtgtgg ccggacccag caacatggct gtccagggaa gaaactacat acctggaccc     1440

agctaccgac aacaacgtgt ctcaaccact gtgactcaaa acaacaacag cgaatttgct     1500

tggcctggag cttcttcttg ggctctcaat ggacgtaata gcttgatgaa tcctggacct     1560

gctatggcca gccacaaaga aggagaggac cgtttctttc ctttgtctgg atctttaatt     1620

tttggcaaac aaggaactgg aagagacaac gtggatgcgg acaaagtcat gataaccaac     1680

gaagaagaaa ttaaaactac taacccggta gcaacggagt cctatggaca agtggccaca     1740

aaccaccaga gtgcccaagc acaggcgcag accggctggg ttcaaaacca aggaatactt     1800

ccgggtatgg tttggcagga cagagatgtg tacctgcaag gacccatttg ggccaaaatt     1860

cctcacacgg acggcaactt tcacccttct ccgctgatgg gagggtttgg aatgaaacac     1920

ccgcctcctc agatcctcat caaaaacaca cctgtacctg cggatcctcc aacggccttc     1980

aacaaggaca agctgaactc tttcatcacc cagtattcta ctggccaagt cagcgtggag     2040

atcgagtggg agctgcagaa ggaaaacagc aagcgctgga accccgagat ccagtacacc     2100

tccaactact acaaatctac aagtgtggac tttgctgtta atacagaagg cgtgtactct     2160

gaaccccgcc ccattggcac ccgttacctc acccgtaatc tgtaa                     2205


<210>  357
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  357

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu Phe Glu 
                405                 410                 415     


Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser Val Ala 
    450                 455                 460                 


Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro Gly Pro 
465                 470                 475                 480 


Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn Asn Asn 
                485                 490                 495     


Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn Gly Arg 
            500                 505                 510         


Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys Glu Gly 
        515                 520                 525             


Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly Lys Gln 
    530                 535                 540                 


Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile Thr Asn 
545                 550                 555                 560 


Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser Tyr Gly 
                565                 570                 575     


Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln Thr Gly 
            580                 585                 590         


Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp Arg 
        595                 600                 605             


Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro 
                645                 650                 655     


Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu 
        675                 680                 685             


Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr 
    690                 695                 700                 


Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly Val Tyr Ser 
705                 710                 715                 720 


Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 


<210>  358
<211>  2217
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  358
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaacctccag cagcgccctc tggtgtggga      600

cctaatacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggagccacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tttcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggag taccagctgc cgtacgttct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtgttca tgattcccca gtacggctac     1140

ctaacactca acaacggtag tcaggccgtg ggacgctcct ccttctactg cctggaatac     1200

tttccttcgc agatgctgag aaccggcaac aacttccagt ttacttacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcccacagc cagagcttgg accggctgat gaatcctctg     1320

attgaccagt acctgtacta cttgtctcgg actcaaacaa caggaggcac ggcaaatacg     1380

cagactctgg gcttcagcca aggtgggcct aatacaatgg ccaatcaggc aaagaactgg     1440

ctgccaggac cctgttaccg ccaacaacgc gtctcaacga caaccgggca aaacaacaat     1500

agcaactttg cctggactgc tgggaccaaa taccatctga atggaagaaa ttcattggct     1560

aatcctggca tcgctatggc aacacacaaa gacgacgagg agcgtttttt tcccagtaac     1620

gggatcctga tttttggcaa acaaaatgct gccagagaca atgcggatta cagcgatgtc     1680

atgctcacca gcgaggaaga aatcaaaacc actaaccctg tggctacaga ggaatacggt     1740

atcgtggcag ataacttgca gcagcaaaac acggctcctc aaattggaac tgtcaacagc     1800

cagggggcct tacccggtat ggtctggcag aaccgggacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccacccct ctcccctcat gggtggattc     1920

ggacttaaac atcctccgcc tcagatcctg atcaagaaca cgcctgtacc tgcggatcct     1980

ccgaccacct tcaaccagtc aaagctgaac tctttcatca cgcaatacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca gcaagcgctg gaaccccgag     2100

atccagtaca cctccaacta ctacaaatct acaagtgtgg actttgctgt taatacagaa     2160

ggcgtgtact ctgaaccccg ccccattggc acccgttacc tcacccgtaa tctgtaa        2217


<210>  359
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  359

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  360
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  360
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcga       60

gagtggtggg cgctgcaacc tggagcccct aaacccaagg caaatcaaca acatcaggac      120

aacgctcggg gtcttgtgct tccgggttac aaatacctcg gacccggcaa cggactcgac      180

aagggggaac ccgtcaacgc agcggacgcg gcagccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggtga caacccctac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca ccagaacctg ggccctgccc acttacaaca accatctcta caagcaaatc      780

tccagccaat caggagcttc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact ttaacagatt ccactgccac ttctcaccac gtgactggca gcgactcatt      900

aacaacaact ggggattccg gcccaagaaa ctcagcttca agctcttcaa catccaagtt      960

aaagaggtca cgcagaacga tggcacgacg actattgcca ataaccttac cagcacggtt     1020

caggtgttta cggactcgga gtatcagctc ccgtacgtgc tcgggtcggc gcaccaaggc     1080

tgtctcccgc cgtttccagc ggacgtcttc atggtccctc agtatggata cctcaccctg     1140

aacaacggaa gtcaagcggt gggacgctca tccttttact gcctggagta cttcccttcg     1200

cagatgctaa ggactggaaa taacttccaa ttcagctata ccttcgagga tgtacctttt     1260

cacagcagct acgctcacag ccagagtttg gatcgcttga tgaatcctct tattgatcag     1320

tatctgtact acctgaacag aacgcaagga acaacctctg gaacaaccaa ccaatcacgg     1380

ctgcttttta gccaggctgg gcctcagtct atgtctttgc aggccagaaa ttggctacct     1440

gggccctgct accggcaaca gagactttca aagactgcta acgacaacaa caacagtaac     1500

tttccttgga cagcggccag caaatatcat ctcaatggcc gcgactcgct ggtgaatcca     1560

ggaccagcta tggccagtca caaggacgat gaagaaaaat ttttccctat gcacggcaat     1620

ctaatatttg gcaaagaagg gacaacggca agtaacgcag aattagataa tgtaatgatt     1680

acggatgaag aagagattcg taccaccaat cctgtggcaa cagagcagta tggaactgtg     1740

gcaaataact tgcagagctc aaatacagct cccacgacta gaactgtcaa tgatcagggg     1800

gccttacctg gcatggtgtg gcaagatcgt gacgtgtacc ttcaaggacc tatctgggca     1860

aagattcctc acacggatgg acactttcat ccttctcctc tgatgggagg ctttggactg     1920

aaacatccgc ctcctcaaat catgatcaaa aatactccgg taccggcaaa tcctccgacg     1980

actttcagcc cggccaagtt tgcttcattt atcactcagt actccactgg acaggtcagc     2040

gtggaaattg agtgggagct acagaaagaa aacagcaaac gttggaatcc agagattcag     2100

tacacttcca actacaacaa gtctgttaat gtggacttta ctgtagacac taatggtgtt     2160

tatagtgaac ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210>  361
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  361

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  362
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  362
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcga       60

gagtggtggg cgctgcaacc tggagcccct aaacccaagg caaatcaaca acatcaggac      120

aacgctcggg gtcttgtgct tccgggttac aaatacctcg gacccggcaa cggactcgac      180

aagggggaac ccgtcaacgc agcggacgcg gcagccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggtga caacccctac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca ccagaacctg ggccctgccc acttacaaca accatctcta caagcaaatc      780

tccagccaat caggagcttc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact ttaacagatt ccactgccac ttctcaccac gtgactggca gcgactcatt      900

aacaacaact ggggattccg gcccaagaaa ctcagcttca agctcttcaa catccaagtt      960

aaagaggtca cgcagaacga tggcacgacg actattgcca ataaccttac cagcacggtt     1020

caagtgttta cggactcgga gtatcagctc ccgtacgtgc tcgggtcggc gcaccaaggc     1080

tgtctcccgc cgtttccagc ggacgtcttc atggtccctc agtatggata cctcaccctg     1140

aacaacggaa gtcaagcggt gggacgctca tccttttact gcctggagta cttcccttcg     1200

cagatgctaa ggactggaaa taacttccaa ttcagctata ccttcgagga tgtacctttt     1260

cacagcagct acgctcacag ccagagtttg gatcgcttga tgaatcctct tattgatcag     1320

tatctgtact acctgaacag aacgcaagga acaacctctg gaacaaccaa ccaatcacgg     1380

ctgcttttta gccaggctgg gcctcagtct atgtctttgc aggccagaaa ttggctacct     1440

gggccctgct accggcaaca gagactttca aagactgcta acgacaacaa caacagtaac     1500

tttccttgga cagcggccag caaatatcat ctcaatggcc gcgactcgct ggtgaatcca     1560

ggaccagcta tggccagtca caaggacgat gaagaaaaat ttttccctat gcacggcaat     1620

ctaatatttg gcaaagaagg gacaacggca agtaacgcag aattagataa tgtaatgatt     1680

acggatgaag aagagattcg taccaccaat cctgtggcaa cagagcagta tggaactgtg     1740

gcaaataact tgcagagctc aaatacagct cccacgacta gaactgtcaa tgatcagggg     1800

gccttacctg gcatggtgtg gcaagatcgt gacgtgtacc ttcaaggacc tatctgggca     1860

aagattcctc acacggatgg acactttcat ccttctcctc tgatgggagg ctttggactg     1920

aaacatccgc ctcctcaaat catgatcaaa aatactccgg taccggcaaa tcctccgacg     1980

actttcagcc cggccaagtt tgcttcattt atcactcagt actccactgg acaggtcagc     2040

gtggaaattg agtgggagct acagaaagaa aacagcaaac gttggaatcc agagattcag     2100

tacacttcca actacaacaa gtctgttaat gtggacttta ctgtagacac taatggtgtt     2160

tatagtgaac ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210>  363
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  363

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  364
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  364
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcgt       60

gagtggtggg ctctgaaacc tggagtccct caacccaaag cgaaccaaca acaccaggac      120

aaccgtcggg gtcttgtgct tccgggttac aaatacctcg gacccggtaa cggactcgac      180

aaaggagagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc catttctcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

caatacctgt attacctgaa cagaactcaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacggatgg acactttcac ccgtctcctc tcatgggcgg ctttggactt     1920

aagcacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggca     1980

gagttttcgg ctacaaagtt tgcttcattc atcacccagt attccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210>  365
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  365

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  366
<211>  2217
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  366
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca acggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaaccaccag cagcccccac aagtttggga      600

tctaatacaa tggcttcagg cggtggcgca ccaatggcag acaataacga gggtgccgat      660

ggagtgggta attcctcagg aaattggcat tgcgattccc aatggctggg cgacagagtc      720

atcaccacca gcacccgcac ctgggccttg cccacctaca ataaccacct ctacaagcaa      780

atctccagtg cttcaacggg ggccagcaac gacaaccact acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa ccgcttccac tgccacttct cgccaagaga ctggcaaaga      900

ctcatcaaca acaattgggg attccggccc aagagactca acttcaaact cttcaacatc      960

caagtcaagg aggtcacgac gaatgatggc gtcacgacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcccac     1080

cagggctgcc tgcctccgtt cccggcggac gtgttcatga ttccccagta tggatacctc     1140

accctgaaca acggaagtca agcggtggga cgctcatcct tttactgcct ggagtacttc     1200

ccttcgcaga tgctaaggac tggaaataac ttccaattca gctatacctt cgaggatgta     1260

ccttttcaca gcagctacgc tcacagccag agtttggatc gcttgatgaa tcctcttatt     1320

gatcagtatc tgtactacct gaacagaacg caaggaacaa cctctggaac aaccaaccaa     1380

tcacggctgc tttttagcca ggctgggcct cagtctatgt ctttgcaggc cagaaattgg     1440

ctacctgggc cctgctaccg gcaacagaga ctttcaaaga ctgctaacga caacaacaac     1500

agtaactttc cttggacagc agccagcaaa tatcatctca atggccgcga ctcgctggtg     1560

aatccaggac cagctatggc cagtcacaag gacgatgaag aaaaattttt ccctatgcac     1620

ggcaatctaa tatttggcaa agaagggaca acggcaagta acgcagaatt agataatgta     1680

atgattacgg atgaagaaga gattcgtacc accaatcctg tggcaacaga gcagtatgga     1740

actgtggcaa ataacttgca gagctcaaat acagctccca cgactagaac tgtcaatgat     1800

cagggggcct tacctggcat ggtgtggcaa gatcgtgacg tgtaccttca ggggcccatc     1860

tgggcaaaga ttccacacac ggacggacat tttcacccct ctcccctcat gggtggattc     1920

ggacttaaac accctcctcc gcagattctc atcaagaaca ccccggtacc tgcgaatcct     1980

tcgaccacct tcagtgcggc aaagtttgct tccttcatca cacagtactc cacgggacag     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggaaaaca gcaagcgctg gaacccggag     2100

atccagtaca cttccaacta ttacaagtct aataatgttg aatttgctgt taatactgaa     2160

ggtgtatata gtgaaccccg ccccattggc accagatacc tgactcgtaa tctgtaa        2217


<210>  367
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  367

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Thr Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn 
            260                 265                 270         


His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn 
        435                 440                 445             


Arg Thr Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn 
                485                 490                 495     


Asp Asn Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser 
        515                 520                 525             


His Lys Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile 
    530                 535                 540                 


Phe Gly Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val 
545                 550                 555                 560 


Met Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala 
            580                 585                 590         


Pro Thr Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asn Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  368
<211>  2208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  368
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg acttgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgatt tcaacagatt ccactgccac ttttcaccac gtgactggca gcgactcatc      900

aacaacaatt ggggattccg gcccaagaga ctcagcttca agctcttcaa catccaggtc      960

aaggaggtca cgcagaatga aggcaccaag accatcgcca ataaccttac cagcacggtt     1020

caagtgttta cggactcgga gtatcagctc ccgtacgtgc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct gattgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggactatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccg tctccgctga tgggcggctt tggcctgaaa     1920

catcctccgc ctcagatcct gatcaagaac acgcctgtac ctgcggatcc tccgaccacc     1980

ttcaaccagt caaagctgaa ctctttcatc actcagtatt ctactggcca agtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaagcgct ggaaccccga gatccagtac     2100

acctccaact actacaaatc tacaagtgtg gactttgctg ttaatacaga aggcgtgtac     2160

tctgaacccc gccccattgg cacccgttac ctcacccgta atctgtaa                  2208


<210>  369
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  369

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Tyr Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp 
                645                 650                 655     


Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  370
<211>  2214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  370
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgatttcaa cagattccac tgccatttct caccacgtga ctggcagcga      900

ctcatcaaca acaattgggg attccggccc aagagactca acttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcccac     1080

cagggctgcc tgcctccgtt cccggcggac gtgttcatga ttccccagta cggctaccta     1140

acactcaaca acggtagtca ggccgtggga cgctcctcct tctactgcct ggaatacttt     1200

ccttcgcaga tgctgagaac cggcaacaac ttccagttta cttacacctt cgaggacgtg     1260

cctttccaca gcagctacgc ccacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacgac aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca gcagcgagta tcaaagacat ttgcggataa caacaacagt     1500

gaatactcgt ggactggagc taccaagtac cacctcaatg gcagagactc tctggtgaat     1560

ccgggcccgg ccatggcaag ccacaaggac gatgaagaaa agttttttcc tcagagcggg     1620

gttctcatct ttgggaagca aggctcagag aaaacaaatg tggacattga aaaggtcatg     1680

attacagacg aagaggaaat caggacaacc aatcccgtgg ctacggagca gtatggttct     1740

gtatctacca acctccagag aggcaacaga caagcagcta ccgcagatgt caacacacaa     1800

ggcgttcttc caggcatggt ctggcaggac agagatgtgt accttcaggg gcccatctgg     1860

gcaaagattc cacacacgga cggacatttt cacccctctc ccctcatggg tggattcgga     1920

cttaaacacc ctccgcctca gatcctgatc aagaacacgc ctgtacccgc ggatcctccg     1980

accaccttca accagtcaaa gctgaactct ttcatcaccc agtattctac tggccaagtc     2040

agcgtggaga tcgagtggga gctgcagaag gaaaacagca agcgctggaa ccccgagatc     2100

cagtacacct ccaactacta caaatctaca agtgtggact ttgctgttaa tacagaaggc     2160

gtgtactctg aaccccgccc cattggcacc cgttacctca cccgtaatct gtaa           2214


<210>  371
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  371

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Thr Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Phe Ala Asp 
                485                 490                 495     


Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala 
            580                 585                 590         


Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  372
<211>  2217
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  372
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaaccaccag cagcccccac aagtttggga      600

tctaatacaa tggcttcagg cggtggcgca ccaatggcag acaataacga gggtgccgat      660

ggagtgggta attcctcagg aaattggcat tgcgattccc aatggctggg cgacagagtc      720

atcaccacca gcacccgcac ctgggccttg cccacctaca ataaccacct ctacaagcaa      780

atctccagtg cttcaacggg ggccagcaac gacaaccact acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa ccgcttccac tgccacttct cgccaagaga ctggcaaaga      900

ctcatcaaca acaattgggg attccggccc aagagactca acttcaaact cttcaacatc      960

caagtcaagg aggtcacgac gaatgatggc gtcacgacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcccac     1080

cagggctgcc tgcctccgtt cccggcggac gtgttcatga ttccccagta tggatacctc     1140

accctgaaca acggaagtca agcggtggga cgctcatcct tttactgcct ggagtacttc     1200

ccttcgcaga tgctaaggac tggaaataac ttccaattca gctatacctt cgaggatgta     1260

ccttttcaca gcagctacgc tcacagccag agtttggatc gcttgatgaa tcctcttatt     1320

gatcagtatc tgtactacct gaacagaacg caaggaacaa cctctggaac aaccaaccaa     1380

tcacggctgc tttttagcca ggctgggcct cagtctatgt ctttgcaggc cagaaattgg     1440

ctacctgggc cctgctaccg gcaacagaga ctttcaaaga ctgctaacga caacaacaac     1500

agtaactttc cttggacagc agccagcaaa tatcatctca atggccgcga ctcgctggtg     1560

aatccaggac cagctatggc cagtcacaag gacgatgaag aaaaattttt ccctatgcac     1620

ggcaatctaa tatttggcaa agaagggaca acggcaagta acgcagaatt agataatgta     1680

atgattacgg atgaagaaga gattcgtacc accaatcctg tggcaacaga gcagtatgga     1740

actgtggcaa ataacttgca gagctcaaat acagctccca cgactagaac tgtcaatgat     1800

cagggggcct tacctggcat ggtgtggcaa gatcgtgacg tgtaccttca ggggcccatc     1860

tgggcaaaga ttccacacac ggacggacat tttcacccct ctcccctcat gggtggattc     1920

ggacttaaac accctcctcc gcagattctc atcaagaaca ccccggtacc tgcgaatcct     1980

tcgaccacct tcagtgcggc aaagtttgct tccttcatca cacagtactc cacgggacag     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggaaaaca gcaagcgctg gaacccggag     2100

atccagtaca cttccaacta ttacaagtct aataatgttg aatttgctgt taatactgaa     2160

ggtgtatata gtgaaccccg ccccattggc accagatacc tgactcgtaa tctgtaa        2217


<210>  373
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  373

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn 
            260                 265                 270         


His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn 
        435                 440                 445             


Arg Thr Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn 
                485                 490                 495     


Asp Asn Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser 
        515                 520                 525             


His Lys Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile 
    530                 535                 540                 


Phe Gly Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val 
545                 550                 555                 560 


Met Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala 
            580                 585                 590         


Pro Thr Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asn Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  374
<211>  2208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  374
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  375
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  375

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  376
<211>  2208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  376
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgcc gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcagctaa aacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc caaaaagaga ctcaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacagca accatctcta caagcaaatc      780

tccagccaat caggagcttc aaacgacaac gactactttg gctacagcac cccttggggg      840

tattttgatt tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgagg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  377
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  377

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Ser Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn Asp Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Glu Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  378
<211>  2208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  378
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttc      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcttc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact ttaacagatt ccactgccac ttttcaccac gtgactggca gcgactcatt      900

aacaacaact ggggattccg gcccaagaaa ctcaacttca agctctttaa catccaggtc      960

aaggaggtca cgcagaatga aggcaccaag accatcgcca ataacctcac cagcaccatc     1020

caggtgttta cggactcgga gtaccagctg ccgtacgttc tcggctctgc ccaccagggc     1080

tgcctgcctc cgttcccggc ggacgtgttc atgattcccc agtacggcta cctaacactc     1140

aacaacggta gtcaggccgt gggacgctcc tccttctact gcctggaata ctttccttcg     1200

cagatgctga gaaccggcaa caacttccag tttacttaca ccttcgagga cgtgcctttc     1260

cacagcagct acgcccacag ccagagcttg gaccggctga tgaatcctct gattgaccag     1320

tacctgtatt acttgtctcg gactcaaaca acaggaggca cgacaaatac gcagactctg     1380

ggcttcagcc aaggtgggcc taatacaatg gccaatcagg caaagaactg gctgcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt tatgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acagggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc agggtcccat ttgggccaaa     1860

attcctcaca cagatggaca ctttcacccg tcccctctta tgggcggctt tggactcaag     1920

aacccgcctc ctcagatcct catcaaaaac acgcctgttc ctgcgaatcc tccggcagag     1980

ttttcagcta caaagtttgc ttcattcatc acccaatact ccacaggaca agtgagtgtg     2040

gaaattgaat gggagctgca gaaagaaaac agcaagcgct ggaatcccga agtgcagtac     2100

acatccaatt atgcaaaatc tgccaacgtt gattttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctcacccgta atctgtaa                  2208


<210>  379
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  379

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Gln Thr Thr Gly Gly Thr Thr Asn Thr Gln Thr Leu Gly Phe Ser Gln 
    450                 455                 460                 


Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  380
<211>  2214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  380
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgatttcaa cagattccac tgccatttct caccacgtga ctggcagcga      900

ctcatcaaca acaattgggg attccggccc aagagactca acttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcccac     1080

cagggctgcc tgcctccgtt cccggcggac gtgttcatga ttccccagta cggctaccta     1140

acactcaaca acggtagtca ggccgtggga cgctcctcct tctactgcct ggaatacttt     1200

ccttcgcaga tgctgagaac cggcaacaac ttccagttta cttacacctt cgaggacgtg     1260

cctttccaca gcagctacgc ccacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacgac aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca gcagcgagta tcaaagacat ttgcggataa caacaacagt     1500

gaatactcgt ggactggagc taccaagtac cacctcaatg gcagagactc tctggtgaat     1560

ccgggcccgg ccatggcaag ccacaaggac gatgaagaaa agttttttcc tcagagcggg     1620

gttctcatct ttgggaagca aggctcagag aaaacaaatg tggacattga aaaggtcatg     1680

attacagacg aagaggaaat caggacaacc aatcccgtgg ctacggagca gtatggttct     1740

gtatctacca acctccagag aggcaacaga caagcagcta ccgcagatgt caacacacaa     1800

ggcgttcttc caggcatggt ctggcaggac agagatgtgt accttcaggg gcccatctgg     1860

gcaaagattc cacacacgga cggacatttt cacccctctc ccctcatggg tggattcgga     1920

cttaaacacc ctccgcctca gatcctgatc aagaacacgc ctgtacccgc ggatcctccg     1980

accaccttca accagtcaaa gctgaactct ttcatcaccc agtattctac tggccaagtc     2040

agcgtggaga tcgagtggga gctgcagaag gaaaacagca agcgctggaa ccccgagatc     2100

cagtacacct ccaactacta caaatctaca agtgtggact ttgctgttaa tacagaaggc     2160

gtgtactctg aaccccgccc cattggcacc cgttacctca cccgtaatct gtaa           2214


<210>  381
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  381

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Thr Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Phe Ala Asp 
                485                 490                 495     


Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala 
            580                 585                 590         


Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  382
<211>  2196
<212>  DNA
<213>  Adeno-associated virus

<400>  382
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg caacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacga ggcggacgcc gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caagagcgtc tgcaagaaga tacgtccttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga gggtactcga gcctctgggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaagc ggccagtaga accggactcc agctcgggca tcggcaagtc aggccagcag      480

cccgcgaaaa agagactgaa ttttgggcag actggcgact cagagtcagt gcctgacccc      540

caacctctct cagaaccacc cgcaggtccc tctggtctgg gatctggtac aatggctgct      600

ggcggtggcg ctccaatggc agacaataac gaaggcgccg acggagtggg taatgtctca      660

ggaaattggc attgcgattc cacatggctg ggcgaccgag tcatcaccac cagcactcgg      720

acctgggccc tccccaccta caacaaccac ctctacaagc aaatctccaa cgggacctcg      780

ggaggcagca gcaacgacaa cacctacttt ggctacagca ccccctgggg gtattttgac      840

tttaacagat tccactgcca cttttcacca cgtgactggc agcgactcat caacaacaac      900

tgggggttcc ggcccaagaa gctcaacttc aagctcttca acatccaggt caaggaggtc      960

acccagaatg aaggcaccaa gaccatcgcc aataacctca ccagcacggt gcaggtcttt     1020

acggactcgg agtaccagct cccgtacgtg ctcggctctg cccaccaggg ctgcctgcct     1080

ccgttcccgg cggacgtgtt catgattccg cagtacgggt acctgacgct gaacaacggg     1140

agccaggccg tggggcgatc ctccttctac tgcctggagt actttccctc gcagatgctg     1200

agaacgggca acaactttac cttcagctac accttcgagg acgtgccctt ccacagcagc     1260

tacgcgcaca gccagagcct ggaccggctg atgaacccgc tgattgacca gtacctgtac     1320

tacctgtctc ggactcagac caacgggacc aatgccacgc agactctgtt gtttgctcag     1380

gccgggcctc agaacatgtc ggctcaggcc aagaactggc tgcctggtcc ttgctatcgg     1440

cagcagcgcg tctctacgac agtgtcgcaa aacaacaaca gcaactttac ctggaccggg     1500

gcgaccaagt accacctgaa cggccgagac tccctggtga gccccggtgt cgccatggca     1560

acgcacaagg acgacgagga gcgcttcttc ccgagcagcg gggtcctgat gtttggcaag     1620

cagggcgctg gaaaggacaa tgtcgagtac accaacgtga tgctcaccag cgaggaggag     1680

atcaagacca ccaaccctgt ggccacggag cagtacggcg tggtggctga caatctgcag     1740

cagaccaact cagctcccat tgtgggggca gtcaacagcc agggggcctt acccggtatg     1800

gtctggcaga accgggacgt gtacctgcag ggtcccatct gggccaagat cccgcatacg     1860

gacggcaact ttcacccgtc tcctctcatg ggcggctttg gactgaaaca cccgcctccc     1920

cagatcctga tcaaaaacac gccggtacct gcggatcccc cggtgaactt tacggacgct     1980

aagctggcga gtttcatcac gcagtacagc accgggcagg tcagcgtgga gattgagtgg     2040

gagctgcaga aggagaacag caagcgctgg aatcccgaga ttcagtacac ttccaattat     2100

tataaatcag ctaatgtgga ctttgccgtc aatgcagatg gtgtatatag tgaaccccgc     2160

cccattggca ctcgttacct cacccgtaat ctgtaa                               2196


<210>  383
<211>  731
<212>  PRT
<213>  Adeno-associated virus

<400>  383

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Asp Ser Ser Ser Gly Ile Gly Lys Ser Gly Gln Gln 
145                 150                 155                 160 


Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu Ser 
                165                 170                 175     


Val Pro Asp Pro Gln Pro Leu Ser Glu Pro Pro Ala Gly Pro Ser Gly 
            180                 185                 190         


Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala Asp 
        195                 200                 205             


Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Val Ser Gly Asn Trp His 
    210                 215                 220                 


Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg 
225                 230                 235                 240 


Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser 
                245                 250                 255     


Asn Gly Thr Ser Gly Gly Ser Ser Asn Asp Asn Thr Tyr Phe Gly Tyr 
            260                 265                 270         


Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe 
        275                 280                 285             


Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg 
    290                 295                 300                 


Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val 
305                 310                 315                 320 


Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu Asp Val Pro 
                405                 410                 415     


Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn 
            420                 425                 430         


Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Thr Asn 
        435                 440                 445             


Gly Thr Asn Ala Thr Gln Thr Leu Leu Phe Ala Gln Ala Gly Pro Gln 
    450                 455                 460                 


Asn Met Ser Ala Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg 
465                 470                 475                 480 


Gln Gln Arg Val Ser Thr Thr Val Ser Gln Asn Asn Asn Ser Asn Phe 
                485                 490                 495     


Thr Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asp Ser Leu 
            500                 505                 510         


Val Ser Pro Gly Val Ala Met Ala Thr His Lys Asp Asp Glu Glu Arg 
        515                 520                 525             


Phe Phe Pro Ser Ser Gly Val Leu Met Phe Gly Lys Gln Gly Ala Gly 
    530                 535                 540                 


Lys Asp Asn Val Glu Tyr Thr Asn Val Met Leu Thr Ser Glu Glu Glu 
545                 550                 555                 560 


Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val Val Ala 
                565                 570                 575     


Asp Asn Leu Gln Gln Thr Asn Ser Ala Pro Ile Val Gly Ala Val Asn 
            580                 585                 590         


Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr 
        595                 600                 605             


Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe 
    610                 615                 620                 


His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro 
625                 630                 635                 640 


Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Val Asn 
                645                 650                 655     


Phe Thr Asp Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly 
            660                 665                 670         


Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys 
        675                 680                 685             


Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Ala 
    690                 695                 700                 


Asn Val Asp Phe Ala Val Asn Ala Asp Gly Val Tyr Ser Glu Pro Arg 
705                 710                 715                 720 


Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730     


<210>  384
<211>  2196
<212>  DNA
<213>  Adeno-associated virus

<400>  384
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg caacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacga ggcggacgcc gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caagagcgtc tgcaagaaga tacgtccttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga gggtactcga gcctctgggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaagc ggccagtaga accggactcc agctcgggca tcggcaagtc aggccggcag      480

cccgcgaaaa agagactgaa ttttgggcag actggcgact cagagtcagt gcctgacccc      540

caacctctct cagaaccacc cgcaggtccc tctggtctgg gatctggtac aatggctgca      600

ggcggtggcg ctccaatggc agacaataac gaaggcgccg acggagtggg taatgcctca      660

ggaaattggc attgcgattc cacatggctg ggcgaccgag tcatcaccac cagcactcgg      720

acctgggccc tccccaccta caacaaccac ctctacaagc aaatctccaa cgggacctcg      780

ggaggcagca gcaacgacaa cacctacttt ggctacagca ccccctgggg gtattttgac      840

tttaacagat tccactgcca cttttcacca cgtgactggc agcgactcat caacaacaac      900

tggggattcc ggcccaagag gctcaacttc aagctcttca acatccaggt caaggaggtc      960

acccagaatg aaggcaccaa gaccatcgcc aataacctca ccagcacggt gcaggtcttt     1020

acggactcga agtaccagct cccgtacgtg ctcggctctg cccaccaggg ctgcctgcct     1080

ccgttcccgg cggacgtgtt catgattccg cagtacgggt acctgacgct gaacaacggg     1140

agccaggccg tggggcgatc ctccttctac tgcctggagt actttccctc gcagatgctg     1200

agaacgggca acaactttac cttcagctac accttcgagg acgtgccctt ccacagcagc     1260

tacgcgcaca gccagagcct ggaccggctg atgaacccgc tgattgacca gtacctgtac     1320

tacctgtctc ggactcagac caacgggacc aatgccacgc agactctgtt gtttgctcag     1380

gccgggcctc agaacatgtc ggctcaggcc aagaactggc tgcctggtcc ttgctatcgg     1440

cagcagcgcg tctctacgac agtgtcgcaa aacaacaaca gcaactttac ctggaccggg     1500

gcgaccaagt accacctgaa cggccgagac tccctggtga accccggtgt cgccatggca     1560

acgcacaagg acgacgagga gcgcttcttc ccgagcagcg gggtcctgat gtttggcaag     1620

cagggcgctg gaaaggacaa tgtcgagtac accaacgtga tgctcaccag cgaggaggag     1680

atcaagacca ccaaccctgt ggccacggag cagtacggtg tggtggctga caatctgcag     1740

cagaccaact cggctcccat tgtgggggca gtcaacagcc agggggcctt acccggtatg     1800

gtctggcaga accgggacgt gtacctgcag ggtcccatct gggccaagat cccgcatacg     1860

gacggcaact ttcacccgtc tcctctcatg ggcggctttg gactgaaaca cccgcctccc     1920

cagatcctga tcaaaaacac gccggtacct gcggatcccc cggtgaactt tacggacgct     1980

aagctggcga gtttcatcac gcagtacagc accgggcagg tcagcgtgga gattgagtgg     2040

gagctgcaga aggagaacag caagcgctgg aatcccgaga ttcagtacac ttccaattat     2100

tataaatcag ctaatgtgga ctttgccgtc aatgcagatg gtgtatatag tgaaccccgc     2160

cccattggca ctcgttacct cacccgtaat ctgtaa                               2196


<210>  385
<211>  731
<212>  PRT
<213>  Adeno-associated virus

<400>  385

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Asp Ser Ser Ser Gly Ile Gly Lys Ser Gly Arg Gln 
145                 150                 155                 160 


Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu Ser 
                165                 170                 175     


Val Pro Asp Pro Gln Pro Leu Ser Glu Pro Pro Ala Gly Pro Ser Gly 
            180                 185                 190         


Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala Asp 
        195                 200                 205             


Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp His 
    210                 215                 220                 


Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg 
225                 230                 235                 240 


Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser 
                245                 250                 255     


Asn Gly Thr Ser Gly Gly Ser Ser Asn Asp Asn Thr Tyr Phe Gly Tyr 
            260                 265                 270         


Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe 
        275                 280                 285             


Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg 
    290                 295                 300                 


Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val 
305                 310                 315                 320 


Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Thr Asp Ser Lys Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu Asp Val Pro 
                405                 410                 415     


Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn 
            420                 425                 430         


Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Thr Asn 
        435                 440                 445             


Gly Thr Asn Ala Thr Gln Thr Leu Leu Phe Ala Gln Ala Gly Pro Gln 
    450                 455                 460                 


Asn Met Ser Ala Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg 
465                 470                 475                 480 


Gln Gln Arg Val Ser Thr Thr Val Ser Gln Asn Asn Asn Ser Asn Phe 
                485                 490                 495     


Thr Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asp Ser Leu 
            500                 505                 510         


Val Asn Pro Gly Val Ala Met Ala Thr His Lys Asp Asp Glu Glu Arg 
        515                 520                 525             


Phe Phe Pro Ser Ser Gly Val Leu Met Phe Gly Lys Gln Gly Ala Gly 
    530                 535                 540                 


Lys Asp Asn Val Glu Tyr Thr Asn Val Met Leu Thr Ser Glu Glu Glu 
545                 550                 555                 560 


Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val Val Ala 
                565                 570                 575     


Asp Asn Leu Gln Gln Thr Asn Ser Ala Pro Ile Val Gly Ala Val Asn 
            580                 585                 590         


Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr 
        595                 600                 605             


Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe 
    610                 615                 620                 


His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro 
625                 630                 635                 640 


Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Val Asn 
                645                 650                 655     


Phe Thr Asp Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly 
            660                 665                 670         


Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys 
        675                 680                 685             


Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Ala 
    690                 695                 700                 


Asn Val Asp Phe Ala Val Asn Ala Asp Gly Val Tyr Ser Glu Pro Arg 
705                 710                 715                 720 


Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730     


<210>  386
<211>  2196
<212>  DNA
<213>  Adeno-associated virus

<400>  386
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg caacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacga ggcggacgcc gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caagagcgtc tgcaagaaga tacgtccttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga gggtactcga gcctctgggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaagc ggccagtaga accggactcc agctcgggca tcggcaagtc aggccagcag      480

cccgcgaaaa agagactgaa ttttgggccg actggcgact cagagtcagt gcctgacccc      540

caacctctct cagaaccacc tgcaggtccc tctggtctgg gatctggtac aatggctgca      600

ggcggtggcg ctccaatggc agacaataac gaaggcgccg acggagtggg taatgtctca      660

ggaaattggc attgcgattc cacatggctg ggcgaccgag tcatcaccac cagcactcgg      720

acctgggccc tccccaccta caacaaccac ctctacaagc aaatctccaa cgggacctcg      780

ggaggcagca gcaacgacaa cacctacttt ggctacagca ccccctgggg gtattttgac      840

tttaacagat tccactgcca cttttcacca cgcgactggc agcgactcat caacaacaac      900

tggggattcc ggcccaagaa gctcaacttc aagctcttca acatccaggt caaggaggtc      960

acccagaatg aaggcaccaa gaccaccgcc aataacctca ccagcacggt gcaggtcttt     1020

acggactcgg agtaccagct cccgtacgtg ctcggctctg cccaccaggg ctgcctgcct     1080

ccgttcccgg cggacgtgtt catgattccg cagtacgggt acctgacgct gaacaacggg     1140

agccaggccg tggggcgatc ctccttctac tgcctggagt actttccctc gcagatgctg     1200

agaacgggca acaactttac cttcagctac accttcgagg acgtgccctt ccacagcagc     1260

tacgcgcaca gccagagcct ggaccggctg atgaacccgc tgattgacca gtacctgtac     1320

tacctgtctc ggactcagac caacgggacc aatgccacgc agactctgtt gtttgctcag     1380

gccgggcctc agaacatgtc ggctcaggcc aagaactggc tgcctggtcc ttgctatcgg     1440

cagcagcgcg tctctacggc agtgtcgcaa aacaacaaca gcaactttac ctggaccggg     1500

gcgaccaagt accacctgaa cggccgagac tccctggtga accccggtgt cgccatggca     1560

acgcacaagg acgacgagga gcgcttcttc ccgagcagcg gggtcctgat gtttggcaag     1620

cagggcgctg gaaaggacaa tgtcgagtac accaacgtga tgctcaccag cgaggaggag     1680

atcaagacca ccaaccctgt ggccacggag cagtacggtg tggtggctga caatctgcag     1740

cagaccaact cggctcccat tgtgggggca gtcaacagcc agggggcctt acccggtatg     1800

gtctggcaga accgggacgt gtacctgcag ggtcccatct gggccaagat cccgcatacg     1860

gacggcaact ttcacccgtc tcctctcatg ggcggctttg gactgaaaca cccgcctccc     1920

cagatcctga tcaaaaacac gccggtacct gcggatcccc cggtgaactt tacggacgct     1980

aagctggcga gtttcatcac gcagtacagc accgggcagg tcagcgtgga gattgagtgg     2040

gagctgcaga aggagaacag caagcgctgg aatcccgaga ttcagtacac ttccaattat     2100

tataaatcag ctaatgtgga ctttgccgtc aatgcagatg gtgtatatag cgaaccccgc     2160

cccattggca ctcgttacct cacccgtaat ctgtaa                               2196


<210>  387
<211>  731
<212>  PRT
<213>  Adeno-associated virus

<400>  387

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Asp Ser Ser Ser Gly Ile Gly Lys Ser Gly Gln Gln 
145                 150                 155                 160 


Pro Ala Lys Lys Arg Leu Asn Phe Gly Pro Thr Gly Asp Ser Glu Ser 
                165                 170                 175     


Val Pro Asp Pro Gln Pro Leu Ser Glu Pro Pro Ala Gly Pro Ser Gly 
            180                 185                 190         


Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala Asp 
        195                 200                 205             


Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Val Ser Gly Asn Trp His 
    210                 215                 220                 


Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg 
225                 230                 235                 240 


Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser 
                245                 250                 255     


Asn Gly Thr Ser Gly Gly Ser Ser Asn Asp Asn Thr Tyr Phe Gly Tyr 
            260                 265                 270         


Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe 
        275                 280                 285             


Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg 
    290                 295                 300                 


Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val 
305                 310                 315                 320 


Thr Gln Asn Glu Gly Thr Lys Thr Thr Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu Asp Val Pro 
                405                 410                 415     


Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn 
            420                 425                 430         


Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Thr Asn 
        435                 440                 445             


Gly Thr Asn Ala Thr Gln Thr Leu Leu Phe Ala Gln Ala Gly Pro Gln 
    450                 455                 460                 


Asn Met Ser Ala Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg 
465                 470                 475                 480 


Gln Gln Arg Val Ser Thr Ala Val Ser Gln Asn Asn Asn Ser Asn Phe 
                485                 490                 495     


Thr Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asp Ser Leu 
            500                 505                 510         


Val Asn Pro Gly Val Ala Met Ala Thr His Lys Asp Asp Glu Glu Arg 
        515                 520                 525             


Phe Phe Pro Ser Ser Gly Val Leu Met Phe Gly Lys Gln Gly Ala Gly 
    530                 535                 540                 


Lys Asp Asn Val Glu Tyr Thr Asn Val Met Leu Thr Ser Glu Glu Glu 
545                 550                 555                 560 


Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val Val Ala 
                565                 570                 575     


Asp Asn Leu Gln Gln Thr Asn Ser Ala Pro Ile Val Gly Ala Val Asn 
            580                 585                 590         


Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr 
        595                 600                 605             


Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe 
    610                 615                 620                 


His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro 
625                 630                 635                 640 


Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Val Asn 
                645                 650                 655     


Phe Thr Asp Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly 
            660                 665                 670         


Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys 
        675                 680                 685             


Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Ala 
    690                 695                 700                 


Asn Val Asp Phe Ala Val Asn Ala Asp Gly Val Tyr Ser Glu Pro Arg 
705                 710                 715                 720 


Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730     


<210>  388
<211>  4404
<212>  DNA
<213>  Adeno-associated virus

<400>  388
atggctgccg atggttatct tccagattgg ctcgagggca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aggtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

aagcagctcg agcaggggga caacccgtac ctcaagtaca accacgccga cgccgagttt      300

caggagcgtc ttcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gacccataga atcccccgac tcctccacgg gcatcggcaa gaacggccag      480

ccgcccgcta aaaagaagct caactttggg cagactggcg actcagagtc agtgcccgac      540

ccccaacctc tcggagaacc tcccgccgcg ccctcaggtc tgggatctgg tacaatggct      600

gcaggcggtg gcgcaccaat ggcagacaat aacgaaggcg ccgacggagt gggtaatgcc      660

tccggaaatt ggcattgcga ttccacatgg ctgggcgaca gagtcatcac caccagcacc      720

cgcacctggg ccctgcccac ctacaacaac cacctctaca agcagatatc aagtcagagc      780

ggggctacca acgacaacca cttcttcggc tacagcaccc cctggggcta ttttgacttc      840

aacagattcc actgccactt ctcaccacgt gactggcagc gactcatcaa caacaactgg      900

ggattccggc ccagaaagct gcggttcaag ttgttcaaca tccaggtcaa ggaggtcacg      960

acgaacgacg gcgttacgac catcgctaat aaccttacca gcacgattca ggtcttctcg     1020

gactcggagt accaactgcc gtacgtcctc ggctctgcgc accagggctg cctccctccg     1080

ttccctgcgg acgtgttcat gattcctcag tacggatatc tgactctaaa caacggcagt     1140

cagtctgtgg gacgttcctc cttctactgc ctggagtact ttccttctca gatgctgaga     1200

acgggcgata actttgaatt cagctacacc tttgaggaag tgcctttcca cagcagctat     1260

gcgcacagcc agagcctgga ccggctgatg aatcccctca tcgaccagta cctgtactac     1320

ctggcccgga cccagagcac tacggggtcc acaagggagc tgcagttcca tcaggctggg     1380

cccaacacca tggccgagca atcaaagaac tggctgcccg gaccctgtta tcggcagcag     1440

agactgtcaa aaaacataga cagcaacaac aacagtaact ttgcctggac cggggccact     1500

aaataccatc tgaatggtag aaattcatta accaacccgg gcgtagccat ggccaccaac     1560

aaggacgacg aggaccagtt ctttcccatc aacggagtgc tggtttttgg caaaacgggg     1620

gctgccaaca agacaacgct ggaaaacgtg ctaatgacca gcgaggagga gatcaaaacc     1680

accaatcccg tggctacaga agaatacggt gtggtctcca gcaacctgca atcgtctacg     1740

gccggacccc agacacagac tgtcaacagc cagggggctc tgcccggcat ggtctggcag     1800

aaccgggacg tgtacctgca gggtcccatc tgggccaaaa ttcctcacac ggacggcaac     1860

tttcacccgt ctcccctgat gggcggattt ggactcaaac acccgcctcc tcaaattctc     1920

atcaaaaaca ccccggtacc tgctaatcct ccagaggtgt ttactcctgc caagtttgcc     1980

tcatttatca cgcagtacag caccggccag gtcagcgtgg agatcgagtg ggaactgcag     2040

aaagaaaaca gcaaacgctg gaatccagag attcagtaca cctcaaatta tgccaagtct     2100

aataatgtgg aatttgctgt caacaacgaa ggggtttata ctgagcctcg ccccattggc     2160

acccgttacc tcacccgtaa cctgtaaatg gctgccgatg gttatcttcc agattggctc     2220

gaggacaacc tctctgaggg cattcgcgag tggtgggact tgaaacctgg agccccgaaa     2280

cccaaagcca accagcaaaa gcaggacgac ggccggggtc tggtgcttcc tggctacaag     2340

tacctcggac ccttcaacgg actcgacaag ggggagcccg tcaacgcggc ggacgcagcg     2400

gccctcgagc acgacaaggc ctacgaccag cagctcaaag cgggtgacaa tccgtacctg     2460

cggtataacc acgccgacgc cgagtttcag gagcgtctgc aagaagatac gtcttttggg     2520

ggcaacctcg ggcgagcagt cttccaggcc aagaagcggg ttctcgaacc tctcggtctg     2580

gttgaggaag gcgctaagac ggctcctgga aagaagagac cggtagagcc atcaccccag     2640

cgttctccag actcctctac gggcatcggc aagaaaggcc agcagcccgc gaaaaagaga     2700

ctcaactttg ggcagactgg cgactcagag tcagtgcccg accctcaacc aatcggagaa     2760

ccccccgcag gcccctctgg tctgggatct ggtacaatgg ctgcaggcgg tggcgctcca     2820

atggcagaca ataacgaagg cgccgacgga gtgggtagtt cctcaggaaa ttggcattgc     2880

gattccacat ggctgggcga cagagtcatc accaccagca cccgaacctg ggccctcccc     2940

acctacaaca accacctcta caagcaaatc tccaacggga cttcgggagg aagcaccaac     3000

gacaacacct acttcggcta cagcaccccc tgggggtatt ttgactttaa cagattccac     3060

tgccacttct caccacgtga ctggcagcga ctcatcaaca acaactgggg attccggccc     3120

aagagactca acttcaagct cttcaacatc caggtcaagg aggtcacgca gaatgaaggc     3180

accaagacca tcgccaataa ccttaccagc acgattcagg tctttacgga ctcggaatac     3240

cagctcccgt acgtcctcgg ctctgcgcac cagggctgcc tgcctccgtt cccggcggac     3300

gtcttcatga ttcctcagta cgggtacctg actctgaaca atggcagtca ggccgtgggc     3360

cgttcctcct tctactgcct ggagtacttt ccttctcaaa tgctgagaac gggcaacaac     3420

tttgagttca gctaccagtt tgaggacgtg ccttttcaca gcagctacgc gcacagccaa     3480

agcctggacc ggctgatgaa ccccctcatc gaccagtacc tgtactacct gtctcggact     3540

cagtccacgg gaggtaccgc aggaactcag cagttgctat tttctcaggc cgggcctaat     3600

aacatgtcgg ctcaggccaa aaactggcta cccgggccct gctaccggca gcaacgcgtc     3660

tccacgacac tgtcgcaaaa taacaacagc aactttgcct ggaccggtgc caccaagtat     3720

catctgaatg gcagagactc tctggtaaat cccggtgtcg ctatggcaac ccacaaggac     3780

gacgaagagc gattttttcc gtccagcgga gtcttaatgt ttgggaaaca gggagctgga     3840

aaagacaacg tggactatag cagcgttatg ctaaccagtg aggaagaaat taaaaccacc     3900

aacccagtgg ccacagaaca gtacggcgtg gtggccgata acctgcaaca gcaaaacgcc     3960

gctcctattg taggggccgt caacagtcaa ggagccttac ctggcatggt ctggcagaac     4020

cgggacgtgt acctgcaggg tcctatctgg gccaagattc ctcacacgga cggaaacttt     4080

catccctcgc cgctgatggg aggctttgga ctgaaacacc cgcctcctca gatcctgatt     4140

aagaatacac ctgttcccgc ggatcctcca actaccttca gtcaagctaa gctggcgtcg     4200

ttcatcacgc agtacagcac cggacaggtc agcgtggaaa ttgaatggga gctgcagaaa     4260

gaaaacagca aacgctggaa cccagagatt caatacactt ccaactacta caaatctaca     4320

aatgtggact ttgctgttaa cacagatggc acttattctg agcctcgccc catcggcacc     4380

cgttacctca cccgtaatct gtaa                                            4404


<210>  389
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  389

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Asp 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  390
<211>  3129
<212>  DNA
<213>  Adeno-associated virus

<400>  390
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaaag tgcgcgtgga ccaaaagtgc aagtcgtccg      180

cccagatcga ccccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttgca ggaccggatg ttcaagtttg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac aaagcaggaa gtcagagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca cgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

aaacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaaa aagacgtatc      720

ggaaactctg tgcgattcat catctgctgg gggcgggcac ccgagattgc ttgctcggcc      780

tgcgatctgg tcaacgtgga cctagatgac tgtgtttctg agcaataaat gacttaaacc      840

aggtatggct gccgatggtt atcttccaga ttggctcgag gacaacctct ctgagggcat      900

tcgcgagtgg tgggacttga aacctggagc cccgaaaccc aaagccaacc agcaaaagca      960

ggacgacggc cggggtctgg tgcttcctgg ctacaagtac ctcggaccct tcaacggact     1020

cgacaagggg gagcccgtca acgcggcgga cgcagcggcc ctcgagcacg acaaggccta     1080

cgaccagcag ctcaaagcgg gtgacaatcc gtacctgcgg tataaccacg ccgacgccga     1140

gtttcaggag cgtctgcaag aagatacgtc ttttgggggc aacctcgggc gagcagtctt     1200

ccaggccaag aagcgggttc tcgaacctct cggtctggtt gaggaaggcg ctaagacggc     1260

tcctggaaag aagagaccgg tagagccatc accccagcgt tctccagact cctctacggg     1320

catcggcaag aaaggccagc agcccgcgaa aaagagactc aactttgggc agactggcga     1380

ctcagagtca gtgcccgacc ctcaaccaat cggagaaccc cccgcaggcc cctctggtct     1440

gggatctggt acaatggctg caggcggtgg cgctccaatg gcagacaata acgaaggcgc     1500

cgacggagtg ggtagttcct caggaaattg gcattgcgat tccacatggc tgggcgacag     1560

agtcatcacc accagcaccc gaacctgggc cctccccacc tacaacaacc acctctacaa     1620

gcaaatctcc aacgggactt cgggaggaag caccaacgac aacacctact tcggctacag     1680

caccccctgg gggtattttg actttaacag attccactgc cacttctcac cacgtgactg     1740

gcagcgactc atcaacaaca actggggatt ccggcccaag agactcaact tcaagctctt     1800

caacatccag gtcaaggagg tcacgcagaa tgaaggcacc aagaccatcg ccaataacct     1860

taccagcacg attcaggtct ttacggactc ggaataccag ctcccgtacg tcctcggctc     1920

tgcgcaccag ggctgcctgc ctccgttccc ggcggacgtc ttcatgattc ctcagtacgg     1980

gtacctgact ctgaacaatg gcagtcaggc cgtgggccgt tcctccttct actgcctgga     2040

gtactttcct tctcaaatgc tgagaacggg caacaacttt gagttcagct accagtttga     2100

ggacgtgcct tttcacagca gctacgcgca cagccaaagc ctggaccggc tgatgaaccc     2160

cctcatcgac cagtacctgt actacctgtc tcggactcag tccacgggag gtaccgcagg     2220

aactcagcag ttgctatttt ctcaggccgg gcctaataac atgtcggctc aggccaaaaa     2280

ctggctaccc gggccctgct accggcagca acgcgtctcc acgacactgt cgcaaaataa     2340

caacagcaac tttgcctgga ccggtgccac caagtatcat ctgaatggca gagactctct     2400

ggtaaatccc ggtgtcgcta tggcaaccca caaggacgac gaagagcgat tttttccgtc     2460

cagcggagtc ttaatgtttg ggaaacaggg agctggaaaa gacaacgtgg actatagcag     2520

cgttatgcta accagtgagg aagaaattaa aaccaccaac ccagtggcca cagaacagta     2580

cggcgtggtg gccgataacc tgcaacagca aaacgccgct cctattgtag gggccgtcaa     2640

cagtcaagga gccttacctg gcatggtctg gcagaaccgg gacgtgtacc tgcagggtcc     2700

tatctgggcc aagattcctc acacggacgg aaactttcat ccctcgccgc tgatgggagg     2760

ctttggactg aaacacccgc ctcctcagat cctgattaag aatacacctg ttcccgcgga     2820

tcctccaact accttcagtc aagctaagct ggcgtcgttc atcacgcagt acagcaccgg     2880

acaggtcagc gtggaaattg aatgggagct gcagaaagaa aacagcaaac gctggaaccc     2940

agagattcaa tacacttcca actactacaa atctacaaat gtggactttg ctgttaacac     3000

agatggcact tattctgagc ctcgccccat cggcacccgt tacctcaccc gtaatctgta     3060

attgcttgtt aatcaataaa ccggttgatt cgtttcagtt gaactttggt ctctgcgaag     3120

ggcgaattc                                                             3129


<210>  391
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  391

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Asp 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  392
<211>  733
<212>  PRT
<213>  Adeno-associated virus

<400>  392

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Arg Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Gly Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn Thr Tyr Phe Gly 
            260                 265                 270         


Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His 
        275                 280                 285             


Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe 
    290                 295                 300                 


Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu 
305                 310                 315                 320 


Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser 
                325                 330                 335     


Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu 
            340                 345                 350         


Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe 
        355                 360                 365             


Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala 
    370                 375                 380                 


Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met 
385                 390                 395                 400 


Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Gln Phe Glu Asp Val 
                405                 410                 415     


Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met 
            420                 425                 430         


Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Ser 
        435                 440                 445             


Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu Phe Ser Gln Ala Gly 
    450                 455                 460                 


Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys 
465                 470                 475                 480 


Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Ser Gln Asn Asn Asn Ser 
                485                 490                 495     


Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asp 
            500                 505                 510         


Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr His Lys Gly Asp Glu 
        515                 520                 525             


Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met Phe Gly Lys Gln Gly 
    530                 535                 540                 


Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val Met Leu Thr Ser Glu 
545                 550                 555                 560 


Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val 
                565                 570                 575     


Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala Pro Ile Val Gly Ala 
            580                 585                 590         


Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp 
        595                 600                 605             


Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly 
    610                 615                 620                 


Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro 
625                 630                 635                 640 


Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro 
                645                 650                 655     


Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser 
            660                 665                 670         


Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn 
        675                 680                 685             


Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys 
    690                 695                 700                 


Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Thr Tyr Ser Glu 
705                 710                 715                 720 


Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730             


<210>  393
<211>  2501
<212>  DNA
<213>  Adeno-associated virus

<400>  393
gaattcgccc ttggctgcgt caactggacc aatgagaact ttcccttcaa cgattgcgtc       60

gacaagatgg tgatctggtg ggaggagggc aagatgacgg ccaaggtcgt ggagtccgcc      120

aaggccattc atcatctgct ggggcgggct cccgagattg cttgctcggc ctgcgatctg      180

gtcaacgtgg acctggatga ctgtgtttct gagcaataaa tgacttaaac caggtatggc      240

tgccgatggt tatcttccag attggctcga ggacaacctc tctgagggca ttcgcgagtg      300

gtgggacttg agacctggag ccccgaaacc caaagccaac cagcaaaagc aggacgacgg      360

ccggggtctg gtgcttcctg gctacaagta cctcggaccc ttcaacggac tcgacaaggg      420

agagccggtc aacgaggcag acgccgcggc cctcgagcac gacaaggcct acgacaagca      480

gctcgagcag ggggacaacc cgtacctcaa gtacaaccac gccgacgccg agtttcagga      540

gcgtcttcaa gaagatacgt cttttggggg caacctcggg cgagcagtct tccaggccaa      600

gaagcgggtt ctcgaacctc tcggtctggt tgaggaaggc gctaagacgg ctcctggaaa      660

gaagagaccc atagaatccc ccgactcctc cacgggcatc ggcaagaaag gccagcagcc      720

cgctaaaaag agactcaact ttgggcagac tggcgactca gagtcagtgc ccgaccctca      780

accaatcgga gaaccccccg caggcccctc tggtctggga tctggcacaa tggctgcagg      840

cggtggcgct ccaatggcag acaataacga aggcgccgac ggagtgggta gttcctcagg      900

aaattggcat tgcgattcca catggctggg cgacagagtc atcaccacca gcacccgaac      960

ctgggccctc cccacctaca acaaccacct ctacaagcaa atctccaacg ggacatcggg     1020

aggaagcacc aacgacaaca cctacttcgg ctacagcacc ccctgggggt attttgactt     1080

taacagattc cactgccact tctcaccacg tgactggcag cgactcatca acaacaactg     1140

gggattccgg cccaagagac tcaacttcaa gctcttcaac atccaggtca aggaggtcac     1200

gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc agcacgattc aggtctttac     1260

ggactcggaa taccagctcc cgtacgtcct cggctctgcg caccagggct gcctgcctcc     1320

gttcccggcg gacgtcttca tgattcctca gtacgggtac ctgactctga acaacggcag     1380

tcaggccgtg ggccgttcct ccttctactg cctggagtac tttccttctc aaatgctgag     1440

aacgggcaac aactttgagt tcagctacca gtttgaggac gtgccttttc acagcagcta     1500

tgcgcacagc caaagcctgg accggctgat gaaccccctc atcgaccagt acctgtacta     1560

cctgtctcgg actcagtcca cgggaggtac cgcaggaact cagcagttgc tattttctca     1620

ggccgggcct aataacatgt cggctcaggc caaaaactgg ctacccgggc cctgctaccg     1680

gcagcaacgc gtctccacga cagtgtcgca aaataacaac agcaactttg cttggaccgg     1740

tgccaccaag tatcatctga atggcagaga ctctctggta aatcccggtg tcgctatggc     1800

aacgcacaag ggcgacgaag agcgattttt tccatccagc ggagtcttga tgtttgggaa     1860

acagggagct ggaaaagaca acgtagacta tagcagcgtt atgctaacca gtgaggaaga     1920

aatcaaaacc accaacccag tggccacaga acagtacggc gtggtggccg ataacctgca     1980

acagcaaaac gccgctccta ttgtaggggc cgtcaacagt caaggagcct tacctggcat     2040

ggtctggcag aaccgggacg tgtacctgca gggtcctatc tgggccaaga ttcctcacac     2100

ggacggcaac tttcatcctt cgccgctgat gggaggcttt ggactgaaac acccgcctcc     2160

tcagatcctg attaagaata cacctgttcc cgcggatcct ccaactacct tcagtcaagc     2220

caagctggcg tcgttcatca cgcagtacag caccggacag gtcagcgtgg aaattgaatg     2280

ggagctgcag aaagagaaca gcaagcgctg gaacccagag attcagtata cttccaacta     2340

ctacaaatct acaaatgtgg actttgctgt caatactgag ggtacttatt cagagcctcg     2400

ccccattggc acccgttacc tcacccgtaa cctgtaattg cctgttaatc aataaaccgg     2460

ttgattcgtt tcagttgaac tttggtctca agggcgaatt c                         2501


<210>  394
<211>  2187
<212>  DNA
<213>  Adeno-associated virus

<400>  394
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

aagcagctcg agcaggggga caacccgtac ctcaagtaca accacgccga cgccgagttt      300

caggagcgtc ttcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gacccataga atcccccgac tcctccacgg gcatcggcaa gaaaggccag      480

cagcccgcta aaaagaagct caactttggg cagactggcg actcagagtc agtgcccgac      540

ccccaacctc tcggagaacc tcccgccgcg ccctcaggtc tgggatctgg tacaatggct      600

gcaggcggtg gcgcaccaat ggcagacaat aacgaaggcg ccgacggagt gggtaatgcc      660

tccggaaatt ggcattgcga ttccacatgg ctgggcgaca gagtcatcac caccagcacc      720

cgcacctggg ccctgcccac ctacaacaac cacctctaca agcagatatc aagtcagagc      780

ggggctacca acgacaacca cttcttcggc tacagcaccc cctggggcta ttttgacttc      840

aacagattcc actgccactt ctcaccacgt gactggcagc gactcatcaa caacaactgg      900

ggattccggc ccagaaagct gcggttcaag ttgttcaaca tccaggtcaa ggaggtcacg      960

acgaacgacg gcgttacgac catcgctaat aaccttacca gcacgattca ggtcttctcg     1020

gactcggagt accaactgcc gtacgtcctc ggctctgcgc accagggctg cctccctccg     1080

ttccctgcgg acgtgttcat gattcctcag tacggatatc tgactctaaa caacggcagt     1140

cagtctgtgg gacgttcctc cttctactgc ctggagtact ttccttctca gatgctgaga     1200

acgggcaata actttgaatt cagctacacc tttgaggaag tgcctttcca cagcagctat     1260

gcgcacagcc agagcctgga ccggctgatg aatcccctca tcgaccagta cctgtactac     1320

ctggcccgga cccagagcac tacggggtcc acaagggagc tgcagttcca tcaggctggg     1380

cccaacacca tggccgagca atcaaagaac tggctgcccg gaccctgtta tcggcagcag     1440

agactgtcaa aaaacataga cagcaacaac aacagtaact ttgcctggac cggggccact     1500

aaataccatc tgaatggtag aaattcatta accaacccgg gcgtagccat ggccaccaac     1560

aaggacgacg aggaccagtt ctttcccatc aacggagtgc tggtttttgg cgaaacgggg     1620

gctgccaaca agacaacgct ggaaaacgtg ctaatgacca gcgaggagga gatcaaaacc     1680

accaatcccg tggctacaga agaatacggt gtggtctcca gcaacctgca atcgtctacg     1740

gccggacccc agacacagac tgtcaacagc cagggggctc tgcccggcat ggtctggcag     1800

aaccgggacg tgtacctgca gggtcccatc tgggccaaaa ttcctcacac ggacggcaac     1860

tttcacccgt ctcccctgat gggcggattt ggactcaaac acccgcctcc tcaaattctc     1920

atcaaaaaca ccccggtacc tgctaatcct ccagaggtgt ttactcctgc caagtttgcc     1980

tcatttatca cgcagtacag caccggccag gtcagcgtgg agatcgagtg ggaactgcag     2040

aaagaaaaca gcaaacgctg gaatccagag attcagtaca cctcaaatta tgccaagtct     2100

aataatgtgg aatttgctgt caacaacgaa ggggtttata ctgagcctcg ccccattggc     2160

acccgttacc tcacccgtaa cctgtaa                                         2187


<210>  395
<211>  728
<212>  PRT
<213>  Adeno-associated virus

<400>  395

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Glu Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210>  396
<211>  728
<212>  PRT
<213>  Adeno-associated virus

<400>  396

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210>  397
<211>  728
<212>  PRT
<213>  Adeno-associated virus

<400>  397

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210>  398
<211>  733
<212>  PRT
<213>  Adeno-associated virus

<400>  398

Met Ala Ala Asp Gly His Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Gly Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn Thr Tyr Phe Gly 
            260                 265                 270         


Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His 
        275                 280                 285             


Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Ser Trp Gly Phe 
    290                 295                 300                 


Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu 
305                 310                 315                 320 


Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser 
                325                 330                 335     


Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu 
            340                 345                 350         


Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe 
        355                 360                 365             


Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala 
    370                 375                 380                 


Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met 
385                 390                 395                 400 


Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Gln Phe Glu Asp Val 
                405                 410                 415     


Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met 
            420                 425                 430         


Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Ser 
        435                 440                 445             


Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu Phe Ser Gln Ala Gly 
    450                 455                 460                 


Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys 
465                 470                 475                 480 


Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser Gln Asn Asn Asn Ser 
                485                 490                 495     


Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asp 
            500                 505                 510         


Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr His Lys Asp Asp Glu 
        515                 520                 525             


Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met Phe Gly Lys Gln Gly 
    530                 535                 540                 


Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val Met Leu Thr Ser Glu 
545                 550                 555                 560 


Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val 
                565                 570                 575     


Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala Pro Ile Val Gly Ala 
            580                 585                 590         


Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp 
        595                 600                 605             


Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly 
    610                 615                 620                 


Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro 
625                 630                 635                 640 


Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro 
                645                 650                 655     


Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser 
            660                 665                 670         


Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn 
        675                 680                 685             


Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys 
    690                 695                 700                 


Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Thr Tyr Ser Glu 
705                 710                 715                 720 


Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730             


<210>  399
<211>  3113
<212>  DNA
<213>  Adeno-associated virus

<400>  399
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcgtccg      180

cccagatcga tcccaccccc gtgatcgtca cttccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttaca agaccggatg ttcaaatttg      300

aactcacccg ccgtctggag catgactttg gcaaggtgac aaagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg cttccctgca      600

agacatgcga gagaatgaat cagaatttca gcatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgccattcat catctgctgg ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtca tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaggcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc cgacgccgag     1140

tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagacccat agaatccccc gactcctcca cgggcatcgg caagaaaggc     1320

cagcagcccg ctaaaaagaa gctcaacttt gggcagactg gcgactcaga gtcagtgccc     1380

gaccctcaac caatcggaga accccccgca ggcccctctg gtctgggatc tggtacaatg     1440

gctgcaggcg gtggcgctcc aatggcagac aataacgaag gcgccgacgg agtgggtagt     1500

tcctcaggaa attggcattg cgattccaca tagctgggcg acagagtcat caccaccagc     1560

acccgaacct gggccctccc cacctacaac aaccacctct acaagcaaat ctccaacggg     1620

acatcgggag gaagcaccaa cgacaacacc tacttcggct acagcacccc ctgggggtat     1680

tttgacttta acagattcca ctgccacttc tcaccacgtg actggcagcg actcatcaac     1740

aacagctggg gattccggcc caagagactc aacttcaagc tcttcaacat ccaggtcaag     1800

gaggtcacgc agaatgaagg caccaagacc atcgccaata accttaccag cacgattcag     1860

gtctttacgg actcggaata ccagctcccg tacgtcctcg gctctgcgca ccagggctgc     1920

ctgcctccgt tcccggcgga cgtcttcatg attcctcagt acgggtacct gactctgaac     1980

aacggcagtc aggccgtggg ccgttcctcc ttctactgcc tggagtactt tccttctcaa     2040

atgctgagaa cgggcaacaa ctttgagttc agctaccagt ttgaggacgt gccttttcac     2100

agcagctacg cgcacagcca aagcctggac cggctgatga accccctcat cgaccagtac     2160

ctgtactacc tgtctcggac tcagtccacg ggaggtaccg caggaactca gcagttgcta     2220

ttttctcagg ccgggcctaa taacatgtcg gctcaggcca aaaactggct acccgggccc     2280

tgctaccggc agcaacgcgt ctccacgaca ctgtcgcaaa ataacaacag caactttgct     2340

tggaccggtg ccaccaagta tcatctgaat ggcagagact ctctggtaaa tcccggtgtc     2400

gctatggcaa cgcacaagga cgacgaagag cgattttttc catccagcgg agtcttgatg     2460

tttgggaaac agggagctgg aaaagacaac gtggactata gcagcgttat gctaaccagt     2520

gaggaagaaa tcaaaaccac caacccagtg gccacagaac agtacggcgt ggtggccgat     2580

aacctgcaac agcaaaacgc cgctcctatt gtaggggccg tcaacagtca aggagcctta     2640

cctggcatgg tctggcagaa ccgggacgtg tacctgcagg gtcctatctg ggccaagatt     2700

cctcacacgg acggcaactt tcatccttcg ccgctgatgg gaggctttgg actgaaacac     2760

ccgcctcctc agatcctgat taagaataca cctgttcccg cggatcctcc aactaccttc     2820

agtcaagcca agctggcgtc gttcatcacg cagtacagca ccggacaggt cagcgtggaa     2880

attgaatggg agctgcagaa agagaacagc aagcgctgga acccagagat tcagtatact     2940

tccaactact acaaatctac aaatgtggac tttgctgtca atactgaggg tacttattca     3000

gagcctcgcc ccattggcac ccgttacctc acccgtaacc tgtaattgcc tgttaatcaa     3060

taaaccggtt aattcgtttc agttgaactt tggtctctgc gaagggcgaa ttc            3113


<210>  400
<211>  731
<212>  PRT
<213>  Adeno-associated virus

<400>  400

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Arg Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Arg Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Gln Phe Glu Asp Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Ser Thr Gly 
        435                 440                 445             


Gly Thr Ala Gly Thr Gln Gln Leu Leu Phe Ser Gln Ala Gly Pro Asn 
    450                 455                 460                 


Asn Met Ser Ala Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg 
465                 470                 475                 480 


Gln Gln Arg Val Ser Thr Thr Leu Ser Gln Asn Asn Asn Ser Asn Phe 
                485                 490                 495     


Ala Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asp Ser Leu 
            500                 505                 510         


Val Asn Pro Gly Val Ala Met Ala Thr His Lys Asp Asp Glu Glu Arg 
        515                 520                 525             


Phe Phe Pro Ser Ser Gly Val Leu Met Phe Gly Lys Gln Gly Ala Gly 
    530                 535                 540                 


Lys Asp Asn Val Asp Tyr Ser Ser Val Met Leu Thr Ser Glu Glu Glu 
545                 550                 555                 560 


Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val Val Ala 
                565                 570                 575     


Asp Asn Leu Gln Gln Gln Asn Ala Ala Pro Ile Val Gly Ala Val Asn 
            580                 585                 590         


Ser Gln Gly Ala Leu Pro Gly Met Ala Trp Gln Asn Arg Asp Val Tyr 
        595                 600                 605             


Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe 
    610                 615                 620                 


His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro 
625                 630                 635                 640 


Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Thr 
                645                 650                 655     


Phe Ser Gln Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly 
            660                 665                 670         


Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys 
        675                 680                 685             


Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Thr 
    690                 695                 700                 


Asn Val Asp Phe Ala Val Asn Thr Glu Gly Thr Tyr Ser Glu Pro Arg 
705                 710                 715                 720 


Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730     


<210>  401
<211>  3106
<212>  DNA
<213>  Adeno-associated virus

<400>  401
gaattcgccc ttctacggct gcgtcaactg gaccaatgag aactttccct tcaacgattg       60

cgtcgacaag atggtgatct ggtgggagga gggcaagatg acggccaagg tcgtggagtc      120

cgccaaggcc attctcggcg gcagcaaggt gcgcgtggac caaaagtgca agtcgtccgc      180

ccagatcgac cccacccccg tgatcgtcac ctccaacacc aacatgtgcg ccgtgattga      240

cgggaacagc accaccttcg agcaccagca gccgttgcag gaccggatgt tcaaatttga      300

actcacccgc cgtctggagc atgactttgg caaggcgaca aagcaggaag tcaaagagtt      360

cttccgctgg gcgcaggatc acgtgaccga ggtggcgcat gagttctacg tcagaaaggg      420

tggagccaac aagagacccg cccccgatga cgcggataaa agcgagccca agcgggcccg      480

cccctcagtc gcggatccat cgacgtcaga cgcggaagga gctccggtgg actttgccga      540

caggtaccaa aacaaatgtt ctcgtcacgc gggcatgctt cagatgctgt ttccctgcaa      600

aacatgcgag agaatgaatc agaatttcaa catttgcttc acgcacggga ccagagactg      660

ttcagaatgt ttccccggcg tgtcagaatc tcaaccggtc gtcagaaaga ggacgtatcg      720

gaaactctgt gccattcatc atctgctggg gcgggctccc gagattgctt gctcggcctg      780

cgatctggtc aacgtggacc tggatgactg tgtttctgag caataaatga cttaaaccag      840

gtatggctgc cgatggttat cttccagatt ggctcgagga caacctctct gagggcattc      900

gcgagtggtg ggacttgaaa cctggagccc cgaaacccaa agccaaccag caaaagcagg      960

acgacggccg gggtctggtg cttcctggct acaagtacct cggacccttc aacggactcg     1020

acaagggaga gccggtcaac gaggcagacg ccgcggccct cgagcacgac aaggcctacg     1080

acaagcagct cgagcagggg gacaacccgt acctcaagta caaccacgcc gacgccgagt     1140

ttcaggagcg tcttcaagaa gatacgtctt ttgggggcaa cctcgggcga gcagtcttcc     1200

gggccaagaa gcgggttctc gaacctctcg gtctggttga ggaaggcgct aagacggctc     1260

ctggaaagaa gagacccata gaatcccccg actcctccac gggcatcggc aagaaaggcc     1320

agcagcccgc taaaaagaag ctcaactttg ggcagactgg cgactcagag tcagtgcccg     1380

acccccaacc tctcggagaa cctcccgccg cgccctcagg tctgggatct ggtacaatgg     1440

ctgcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga gtgggtaatg     1500

cctccggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc accaccagca     1560

cccgcacctg ggccctgccc acctacaaca accacctcta caagcagata tcaagtcaga     1620

gcggggctac caacgacaac cacttcttcg gctacagcac cccctggggc tattttgact     1680

tcaacagatt ccactgccac ttctcaccac gtgactggca gcgactcatc aacaacaacc     1740

ggggattccg gcccagaaag ctgcggttca agttgttcaa catccaggtc aaggaggtca     1800

cgacgaacga cggcgttacg accatcgcta ataaccttac cagcacgatt caggtcttct     1860

cggactcgga gtaccaactg ccgtacgtcc tcggctctgc gcaccagggc tgcctccctc     1920

cgttccctgc ggacgtgttc atgattcctc agtacggata tctgactcta aacaacggca     1980

gtcagtctgt gggacgttcc tccttctact gcctggagta ctttccttct cagatgctga     2040

gaacgggcaa taactttgaa ttcagctacc agtttgagga cgtgcccttt cacagcagct     2100

acgcgcacag ccaaagcctg gaccggctga tgaaccccct catcgaccag tacctgtact     2160

acctgtctcg gactcagtcc acgggaggta ccgcaggaac tcagcagttg ctattttctc     2220

aggccgggcc taataacatg tcggctcagg ccaaaaactg gctacccggg ccctgctacc     2280

ggcagcaacg cgtctccacg acactgtcgc aaaataacaa cagcaacttt gcttggaccg     2340

gtgccaccaa gtatcatctg aatggcagag actctctggt aaatcccggt gtcgctatgg     2400

caacgcacaa ggacgacgaa gagcgatttt ttccatccag cggagtcttg atgtttggga     2460

aacagggagc tggaaaagac aacgtggact atagcagcgt tatgctaacc agtgaggaag     2520

aaatcaaaac caccaaccca gtggccacag aacagtacgg cgtggtggcc gataacctgc     2580

aacagcaaaa cgccgctcct attgtagggg ccgtcaacag tcaaggagcc ttacctggca     2640

tggcctggca gaaccgggac gtgtacctgc agggtcctat ctgggccaag attcctcaca     2700

cggacggcaa ctttcatcct tcgccgctga tgggaggctt tggactgaaa cacccgcctc     2760

ctcagatcct gattaagaat acacctgttc ccgcggatcc tccaactacc ttcagtcaag     2820

ccaagctggc gtcgttcatc acgcagtaca gcaccggaca ggtcagcgtg gaaattgaat     2880

gggagctgca gaaagagaac agcaagcgct ggaacccaga gattcagtat acttccaact     2940

actacaaatc tacaaatgtg gactttgctg tcaatactga gggtacttat tcagagcctc     3000

gccccattgg cacccgttac ctcacccgta acctgtaatt gcctgttaat caataaaccg     3060

gttaattcgt ttcagttgaa ctttggtctc tgcgaagggc gaattc                    3106


<210>  402
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  402

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  403
<211>  3197
<212>  DNA
<213>  Adeno-associated virus

<400>  403
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcgtccg      180

cccagatcga ccccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttaca agaccggatg ttcaaatttg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac aaagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

agacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgccattcat catctgctgg ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaagggag agccggtcaa cgaggcagac gccgcggccc tcgagcacga caaggcctac     1080

gacaagcagc tcgagcaggg ggacaacccg tacctcaagt acaaccacgc cgacgccgag     1140

tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagaccggt agagccatca ccccagcgtt ctccagactc ctctacgggc     1320

atcggcaaga caggccagca gcccgcgaaa aagagactca actttgggca gactggcgac     1380

tcagagtcag tgcccgaccc tcaaccaatc ggagaacccc ccgcaggccc ctctggtctg     1440

ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa cgaaggcgcc     1500

gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct gggcgacaga     1560

gtcatcacca ccagcacccg aacctgggcc ctccccacct acaacaacca cctctacaag     1620

caaatctcca acgggacatc gggaggaagc accaacgaca acacctactt cggctacagc     1680

accccctggg ggtattttga ctttaacaga ttccactgcc acttctcacc acgtgactgg     1740

cagcgactca tcaacaacaa ctggggattc cggcccaaga gactcaactt caagctcttc     1800

aacatccagg tcaaggaggt cacgcagaat gaaggcacca agaccatcgc caataacctt     1860

accagcacga ttcaggtctt tacggactcg gaataccagc tcccgtacgt cctcggctct     1920

gcgcaccagg gctgcctgcc tccgttcccg gcggacgtct tcatgattcc tcagtacggg     1980

tacctgactc tgaacaacgg cagtcaggcc gtgggccgtt cctccttcta ctgcctggag     2040

tactttcctt ctcaaatgct gagaacgggc aacaactttg agttcagcta ccagtttgag     2100

gacgtgcctt ttcacagcag ctacgcgcac agccaaagcc tggaccggct gatgaacccc     2160

ctcatcgacc agtacctgta ctacctgtct cggactcagt ccacgggagg taccgcagga     2220

actcagcagt tgctattttc tcaggccggg cctaataaca tgtcggctca ggccaaaaac     2280

tggctacccg ggccctgcta ccggcagcaa cgcgtctcca cgacactgtc gcaaaataac     2340

aacagcaact ttgcttggac cggtgccacc aagtatcatc tgaatggcag agactctctg     2400

gtaaatcccg gtgtcgctat ggcaacgcac aaggacgacg aagagcgatt ttttccatcc     2460

agcggagtct tgatgtttgg gaaacaggga gctggaaaag acaacgtgga ctatagcagc     2520

gttatgctaa ccagtgagga agaaatcaaa accaccaacc cagtggccac agaacagtac     2580

ggcgtggtgg ccgataacct gcaacagcaa aacgccgctc ctattgtagg ggccgtcaac     2640

agtcaaggag ccttacctgg catggtctgg cagaaccggg acgtgtacct gcagggtcct     2700

atctgggcca agattcctca cacggacggc aactttcatc cttcgccgct gatgggaggc     2760

tttggactga aacacccgcc tcctcagatc ctgattaaga atacacctgt tcccgcggat     2820

cctccaacta ccttcagtca agccaagctg gcgtcgttca tcacgcagta cagcaccgga     2880

caggtcagcg tggaaattga atgggagctg cagaaagaga acagcaagcg ctggaaccca     2940

gagattcagt atacttccaa ctactacaaa tctacaaatg tggactttgc tgtcaatact     3000

gagggtactt attcagagcc tcgccccatt ggcacccgtt acctcacccg taacctgtaa     3060

ttgcctgtta atcaataaac cggttaattc gtttcagttg aactttggtc tctgcgaagg     3120

gcgaattcgt ttaaacctgc aggactagtc cctttagtga gggttaattc tgagcttggc     3180

gtaatcatgg gtcatag                                                    3197


<210>  404
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  404

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Arg Lys Leu Arg Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Thr Asp Asp Gly Val Thr Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Ser Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ala Arg Thr Gln Ser Thr Thr Gly Ser Thr Arg Glu Leu Gln Phe His 
    450                 455                 460                 


Gln Ala Gly Pro Asn Thr Met Ala Glu Gln Ser Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Asn Ile Asp Ser Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Thr Asn Pro Gly Val Ala Met Ala Thr Asn Lys 
        515                 520                 525             


Asp Asp Glu Asp Gln Phe Phe Pro Ile Asn Gly Val Leu Val Phe Gly 
    530                 535                 540                 


Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu Met Thr 
545                 550                 555                 560 


Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr 
                565                 570                 575     


Gly Val Val Ser Ser Asn Leu Gln Ser Ser Thr Ala Gly Pro Gln Thr 
            580                 585                 590         


Gln Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly Asn Phe His Pro Ser Pro Leu Met Asp Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Ala Lys Ser Asn Asn Val Glu Phe Ala Val Asn Asn Glu Gly Val Tyr 
705                 710                 715                 720 


Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  405
<211>  3276
<212>  DNA
<213>  Adeno-associated virus

<400>  405
gaattcgccc ttcgcagaga ccaaagttca actgaaacga attaaccggt ttattgatta       60

acaggcaatt acaggttacg ggtgaggtaa cgggtgccaa tggggcgagg ctcagtataa      120

accccttcgt tgttgacagc aaattccaca ttattagact tggcataatt tgaggtgtac      180

tgaatctctg gattccagcg tttgctgttt tctttctgca gttcccactc gatctccacg      240

ctgacctggc cggtgctgta ctgcgtgata aatgaggcaa acttggcagg agtaaacacc      300

tctggaggat tagcaggtac cggggtgttt ttgatgagaa tttgaggagg cgggtgtttg      360

agtccaaatc cgtccatcag gggagacggg tgaaagttgc cgtccgtgtg aggaattttg      420

gcccagatgg gaccctgcag gtacacgtcc cggttctgcc agaccatgcc gggcagagcc      480

ccctggctgt tgacagtctg tgtctggggt ccggccgtag acgattgcag gttgctggag      540

accacaccgt attcttctgt agccacggga ttggtggttt tgatctcctc ctcgctggtc      600

attagcacgt tttccagcgt tgtcttgttg gcagcccccg ttttgccaaa aaccagcact      660

ccgttgatgg gaaagaactg gtcctcgtcg tccttgttgg tggccatggc tacgcccggg      720

ttggttaatg aatttctacc attcagatgg tatttagtgg ccccggtcca ggcaaagtta      780

ctgttgttgt tgctgtctat gttttttgac agtctctgct gccgataaca gggtccgggc      840

agccagttct ttgattgctc ggccatggtg ttgggcccag cctgatggaa ctgcagctcc      900

cttgtggacc ccgtagtgct ctgggtccgg gccaggtagt acaggtactg gtcgatgagg      960

ggattcatca gccggtccag gctctggcta tgcgcatagc tgctgtggaa aggcacttcc     1020

tcaaaggtgt agctgaattc aaagttattg cccgttctca gcatctgaga aggaaagtac     1080

tccaggcagt agaaggagga acgtcccaca gactgactgc cgttgtttag agtcagatat     1140

ccgtactgag gaatcatgaa cacgtccgca gggaacggag ggaggcagcc ctggtgcgca     1200

gagccgagga cgtacggcag ttggtactcc gagtccgaga agacctgaat cgtgctggta     1260

aggttattag cgatggtcgt aacgccgtcg tccgtcgtga cctccttgac ctggatgttg     1320

aacaacttga accgcagctt tctgggccgg aatccccagt tgttgttgat gagtcgctgc     1380

cagtcacgtg gtgagaagtg gcagtggaat ctgttaaagt caaaataccc ccagggggtg     1440

ctgtagccga agtaggtgtt gtcgttggtg cttcctcccg atgtcccgtt ggagatttgc     1500

ttgtagaggt ggttgttgta ggtggggagg gcccaggttc gggtgctggt ggtgatgact     1560

ctgtcgccca gccatgtgga atcgcaatgc caatttcctg aggaactacc cactccgtcg     1620

gcgccttcgt tattgtctgc cattggagcg ccaccgcctg cagccattgt accagatccc     1680

agaccagagg ggcctgcggg gggttctccg attggttgag ggtcgggcac tgactctgag     1740

tcgccagtct gcccaaagtt gagtctcttt ttcgcgggct gctggcctgt cttgccgatg     1800

cccgtagagg agtctggaga acgctggggt gatggctcta ccggtctctt ctttccagga     1860

gccgtcttag cgccttcctc aaccagaccg agaggttcga gaacccgctt cttggcctgg     1920

aagactgctc gcccgaggtt gcccccaaaa gacgtatctt cttgaagacg ctcctgaaac     1980

tcggcgtcgg cgtggttgta cttgaggtac gggttgtccc cctgctcgag ctgcttgtcg     2040

taggccttgt cgtgctcgag ggccgcggcg tctgcctcgt tgaccggctc tcccttgtcg     2100

agtccgttga agggtccgag gtacttgtag ccaggaagca ccagaccccg gccgtcgtcc     2160

tgcttttgct ggttggcttt gggtttcggg gctccaggtt tcaagtccca ccactcgcga     2220

atgccctcag agaggttgtc ctcgagccaa tctggaagat aaccatcggc agccatacct     2280

ggtttaagtc atttattgct cagaaacaca gtcatccagg tccacgttga ccagatcgca     2340

ggccgagcaa gcaatctcgg gagcccgccc cagcagatga tgaatggcac agagtttccg     2400

atacgtcctc tttctgacga ccggttgaga ttctgacacg ccggggaaac attctgaaca     2460

gtctctggtc ccgtgcgtga agcaaatgtt gaaattctga ttcattctct cgcatgtctt     2520

gcagggaaac agcatctgaa gcatgcccgc gtgacgagaa cacttgtttt ggtacctgtc     2580

ggcaaagtcc accggagctc cttccgcgtc tgacgtcgat ggatgcaaaa tgtcgcaaaa     2640

gcactcacgt gacagctaat acaggaccac tcccctatga cgtgatttac gtcagcgcta     2700

tgcccgcgtg acgagaacat ttgttttggt acctgtcggc aaagtccacc ggagctcctt     2760

ccgcgtctga cgtcgatgga tccgcgactg aggggcaggc ccgcttgggc tcgcttttat     2820

ccgcgtcatc gggggcgggt ctcttgttgg ctccaccctt tctgacgtag aactcatgcg     2880

ccacctcggt cacgtgatcc tgcgcccagc ggaagaactc tttgacttcc tgctttgtca     2940

ccttgccaaa gtcatgctcc agacggcggg tgagttcaaa tttgaacatc cggtcctgca     3000

acggctgctg gtgctcgaag gtggtgctgt tcccgtcaat cacggcgcac atgttggtgt     3060

tggaagtgac gatcacgggg gtgggatcga tctgggcgga agacttgcac ttttggtcca     3120

cgcgcacctt gctgccgccg agaatggcct tggcggactc cacgaccttg gccgtcatct     3180

tgccctcctc ccaccagatc accatcttgt cgacgcaatc gttgaaggga aagttctcat     3240

tggtccagtt gacgcagccg tagaaagggc gaattc                               3276


<210>  406
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  406

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Pro Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Gly Ala 
            580                 585                 590         


Pro Ile Val Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Val Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  407
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  407

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Pro Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Gly Ala 
            580                 585                 590         


Pro Ile Val Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  408
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  408

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  409
<211>  728
<212>  PRT
<213>  Adeno-associated virus

<400>  409

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Arg Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Gly Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210>  410
<211>  2489
<212>  DNA
<213>  Adeno-associated virus

<400>  410
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtgaagt      120

ccgccaaggc cattcatcat ctgctggggc gggctcccga gattgcttgc tcggcctgcg      180

atctggtcaa cgtggacctg gatgactgtg tttctgagca ataaatgact taaaccaggt      240

atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc      300

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      360

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      420

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      480

aagcagctcg agcaggggga caacccgtac ctcaagtaca accacgccga cgccgagttt      540

caggagcgtc ttcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      600

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      660

ggaaagaaga gacccataga atcccccgac tcctccacgg gcatcggcag gaaaggccag      720

cagcccgcta aaaagaagct caactttggg cagactggcg actcagagtc agtgcccgac      780

cctcaaccaa tcggagaacc ccccgcaggc ccctctggtc tgggatctgg tacaatggct      840

gcaggcggtg gcgctccaat ggcagacaat aacgaaggcg ccgacggagt gggtaatgcc      900

tccggaaatt ggcattgcga ttccacatgg ctgggcgaca gagtcatcac caccagcacc      960

cgcacctggg ccctgcccac ctacaacaac cacctctaca agcagatatc aagtcagagc     1020

ggggctacca acgacaacca cttcttcggc tacagcaccc cctggggcta ttttgacttc     1080

aacagattcc actgccactt ctcaccacgt gactggcagc gactcatcaa caacaactgg     1140

ggattccggc ccagaaagct gcggttcaag ttgttcaaca tccaggtcaa ggaggtcacg     1200

acgaacgacg gcgttacgac catcgccaat aaccttacca gcacgattca ggtcttctcg     1260

gactcggagt accaactgcc gtacgtcctc ggctctgcgc accagggctg cctccctccg     1320

ttccctgcgg acgtgttcat gattcctcag tacggatatc tgactctaaa caacggcagt     1380

cagtctgtgg gacgttcctc cttctactgc ctggagtact ttccttctca gatgctgaga     1440

acgggcaata actttgaatt cagctacacc tttgaggaag tgcctttcca cagcagctat     1500

gcgcacagcc agagcctgga ccggctgatg aatcccctca tcgaccagta cctgtactac     1560

ctggcccgga cccagagcac tacggggtcc acaagggagc tgcagttcca tcaggctggg     1620

cccaacacca tggccgagca atcaaagaac tggctgcccg gaccctgtta tcggcagcag     1680

agactgtcaa aaaacataga cagcaacaac aacagtaact ttgcctggac cggggccact     1740

aaataccatc tgaatggtag aaattcatta accaacccgg gcgtagccat ggccaccaac     1800

aaggacgacg aggaccagtt ctttcccatc aacggagtgc tggtttttgg caaaacgggg     1860

gctgccaaca agacaacgct ggaaaacgtg ctaatgacca gcgaggagga gatcaaaacc     1920

accaatcccg tggctacaga agaatacggt gtggtctcca gcaacctgca atcgtctacg     1980

gccggacccc agacacagac tgtcaacagc cagggggctc tgcccggcat ggtctggcag     2040

aaccgggacg tgtacctgca gggtcccatc tgggccaaaa ttcctcacac ggacggcaac     2100

tttcacccgt ctcccctgat gggcggattt ggactcaaac acccgcctcc tcaaattctc     2160

atcaaaaaca ccccggtacc tgctaatcct ccagaggtgt ttactcctgc caagtttgcc     2220

tcatttatca cgcagtacag caccggccag gtcagcgtgg agatcgagtg ggaactgcag     2280

aaagaaaaca gcaaacgctg gaatccagag attcagtaca cctcaaatta tgccaagtct     2340

aataatgtgg aatttgctgt caacaacgaa ggggtttata ctgagcctcg ccccattggc     2400

acccgttacc tcacccgtaa cctgtaattg cctgttaatc aataaaccgg ttaattcgtt     2460

tcagttgaac tttggtcaag ggcgaattc                                       2489


<210>  411
<211>  728
<212>  PRT
<213>  Adeno-associated virus

<400>  411

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Gly Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Arg Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asp Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210>  412
<211>  3098
<212>  DNA
<213>  Adeno-associated virus

<400>  412
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcttccg      180

cccagatcga tcccaccccc gtgatcgtca cttccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttaca agaccggatg ttcaaatttg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac aaagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

agacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accggagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgccattcat catctgctgg ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaagggag agccggtcaa cgcggcggac gcagcggccc tcgagcacga caaggcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc cgacgccgag     1140

tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagacccat agaatccccc gactcctcca cgggcatcgg caagaaaggc     1320

cagcagcccg ctaaaaagaa gctcaacttt gggcagactg gcgactcaga gtcagtgccc     1380

gaccctcaac caatcggaga accccccgca ggcccctctg gtctgggatc tggtacaatg     1440

gctgcaggcg gtggcgctcc aatggcagac aataacgaag gcgccgacgg agtgggtaat     1500

gcctccggaa attggcattg cgattccaca tggctgggcg acagagtcat caccaccagc     1560

acccgcacct gggccctgcc cacctacaac aaccacctct acaagcagat atcaagtcag     1620

agcggggcta ccaacgacaa ccacttcttc ggctacagca ccccctgggg ctattttgac     1680

ttcaacagat tccactgcca cttctcacca cgtgactggc agcgactcat caacaacaac     1740

tggggattcc ggcccagaaa gctgcggttc aagttgttca acatccaggt caaggaggtc     1800

acgacgaacg acggcgttac gaccatcgct aataacctta ccagcacgat tcaggtcttc     1860

tcggactcgg agtaccaact gccgtacgtc ctcggctctg cgcaccaggg ctgcctccct     1920

ccgttccctg cggacgtgtt catgattcct cagtacggat atctgactct aaacaacggc     1980

agtcagtctg tgggacgttc ctccttctac tgcctggagt actttccttc tcagatgctg     2040

agaacgggca ataactttga attcagctac acctttgagg aagtgccttt ccacagcagc     2100

tatgcgcaca gccagagcct ggaccggctg atgaatcccc tcatcgacca gtacctgtac     2160

tacctggccc ggacccagag cactacgggg tccacaaggg agctgcagtt ccatcaggct     2220

gggcccaaca ccatggccga gcaatcaaag aactggctgc ccggaccctg ttatcggcgg     2280

cagagactgt caaaagacat agacagcaac aacaacagta actttgcctg gaccggggcc     2340

actaaatacc atctgaatgg tagaaattca ttaaccaacc cgggcgtagc catggccacc     2400

aacaaggacg acgaggacca gttctttccc atcaacggag tgctggtttt tggcaaaacg     2460

ggggctgcca acaagacaac gctggaaaac gtgctaatga ccagcgagga ggagatcaaa     2520

accaccaatc ccgtggctac agaagaatac ggtgtggtct ccagcaacct gcaatcgtct     2580

acggccggac cccagacaca gactgtcaac agccaggggg ctctgcccgg catggtctgg     2640

cagaaccggg acgtgtacct gcagggtccc atctgggcca aaattcctca cacggacggc     2700

aactttcacc cgtctcccct gatgggcgga tttggactca aacacccgcc tcctcaaatt     2760

ctcatcaaaa acaccccggt acctgctaat cctccagagg tgtttactcc tgccaagttt     2820

gcctcattta tcacgcagta cagcaccggc caggtcagcg tggagatcga gtgggaactg     2880

cagaaagaga acagcaaacg ctggaatcca gagattcagt acacctcaaa ttatgccaag     2940

tctaataatg tggaatttgc tgtcaacaac gaaggggttt atactgagcc tcgccccatt     3000

ggcacccgtt acctcacccg taacctgtaa ttacttgtta atcaataaac cggttgattc     3060

gtttcagttg aactttggtc tctgcgaagg gcgaattc                             3098


<210>  413
<211>  685
<212>  PRT
<213>  Adeno-associated virus

<400>  413

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Thr Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ala Arg Thr Gln Ser Thr Thr Gly Ser Thr Arg Gly Leu Gln Phe His 
    450                 455                 460                 


Gln Ala Gly Pro Asn Thr Met Ala Glu Gln Ser Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Asn Ile Asp Ser Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Thr Asn Pro Gly Val Ala Met Ala Thr Asn Lys 
        515                 520                 525             


Asp Asp Glu Asp Gln Phe Phe Pro Ile Asn Gly Val Leu Val Phe Gly 
    530                 535                 540                 


Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu Met Thr 
545                 550                 555                 560 


Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr 
                565                 570                 575     


Gly Val Val Ser Ser Asn Leu Gln Ser Ser Thr Ala Gly Pro Gln Thr 
            580                 585                 590         


Gln Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Tyr Thr Ser Asn Tyr Tyr Lys 
                645                 650                 655     


Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Thr Tyr Ser Glu 
            660                 665                 670         


Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
        675                 680                 685 


<210>  414
<211>  2969
<212>  DNA
<213>  Adeno-associated virus

<400>  414
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcgtccg      180

cccagatcga ccccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttaca agaccggatg ttcaaatttg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac aaagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

agacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgccattcat catctgctgg ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatc      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaagggag agccggtcaa cgaggcagac gccgcggccc tcgagcacga caaggcctac     1080

gacaagcagc tcgagcaggg ggacaacccg tacctcaagt acaaccacgc cgacgccgag     1140

tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagaccggt agagccatca ccccagcgtt ctccagactc ctctacgggc     1320

atcggcaaga caggccagca gcccgcgaaa aagagactca actttgggca gactggcgac     1380

tcagagtcag tgcccgaccc tcaaccaatc ggagaacccc ccgcaggccc ctctggtctg     1440

ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa cgaaggcgcc     1500

gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct gggcgacaga     1560

gtcatcacca ccagcacccg aacctgggcc ctccccacct acaacaacca cctctacaag     1620

caaatctcca acgggacatc gggaggaagc accaacgaca acacctactt cggctacagc     1680

accccctggg ggtattttga ctttaacaga ttccactgcc acttctcacc acgtgactgg     1740

cagcgactca tcaacaacaa ctggggattc cggcccaaga gactcaactt caagctcttc     1800

aacatccagg tcaaggaggt cacgcagaat gaaggcacca agaccatcgc caataacctt     1860

accagcacga ttcaggtctt tacggactcg gaataccagc tcccgtacgt cctcggctct     1920

gcgcaccagg gctgcctgcc tccgttcccg gcggacgtct tcatgattcc tcagtacggg     1980

tacctgactc tgaacaacgg cagtcaggcc gtgggccgtt cctccttcta ctgcctggag     2040

tactttcctt ctcaaatgct gagaacgggc aacaactttg agttcagcta ccagtttgag     2100

gacgtgcctt ttcacagcag ctacgcgcac agccaaagcc tggaccggct gacgaacccc     2160

ctcatcgacc agtacctgta ctacctggcc cggacccaga gcactacggg gtccacaagg     2220

gggctgcagt tccatcaggc tgggcccaac accatggccg agcaatcaaa gaactggctg     2280

cccggaccct gttatcggca gcagagactg tcaaaaaaca tagacagcaa caacaacagt     2340

aactttgcct ggaccggggc cactaaatac catctgaatg gtagaaattc attaaccaac     2400

ccgggcgtag ccatggccac caacaaggac gacgaggacc agttctttcc catcaacgga     2460

gtgctggttt ttggcaaaac gggggctgcc aacaagacaa cgctggaaaa cgtgctaatg     2520

accagcgagg aggagatcaa aaccaccaat cccgtggcta cagaagaata cggtgtggtc     2580

tccagcaacc tgcaatcgtc tacggccgga ccccagacac agactgtcaa cagccagggg     2640

gctctgcccg gcatggtctg gcagaaccgg gacgtgtacc tgcagggtcc catctgggcc     2700

aaaattcctc acacggacgg caactttcac ccgtctcccc tgatgggcgg atttggactc     2760

aaacacccgc ctcctcaaat tctcatcaag tatacttcca actactacaa atctacaaat     2820

gtggactttg ctgtcaatac tgagggtact tattcagagc ctcgccccat tggcacccgt     2880

tacctcaccc gtaacctgta attgcctgtt aatcaataaa ccggttaatt cgtttcagtt     2940

gaactttggt ctctgcgaag ggcgaattc                                       2969


<210>  415
<211>  733
<212>  PRT
<213>  Adeno-associated virus

<400>  415

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Gly Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn Thr Tyr Phe Gly 
            260                 265                 270         


Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His 
        275                 280                 285             


Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe 
    290                 295                 300                 


Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu 
305                 310                 315                 320 


Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser 
                325                 330                 335     


Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu 
            340                 345                 350         


Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe 
        355                 360                 365             


Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala 
    370                 375                 380                 


Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met 
385                 390                 395                 400 


Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Gln Phe Glu Asp Val 
                405                 410                 415     


Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met 
            420                 425                 430         


Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Ser 
        435                 440                 445             


Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu Phe Ser Gln Ala Gly 
    450                 455                 460                 


Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys 
465                 470                 475                 480 


Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Ser Gln Asn Asn Asn Ser 
                485                 490                 495     


Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asp 
            500                 505                 510         


Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr His Lys Gly Asp Glu 
        515                 520                 525             


Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met Phe Gly Lys Gln Gly 
    530                 535                 540                 


Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val Met Leu Thr Ser Glu 
545                 550                 555                 560 


Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val 
                565                 570                 575     


Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala Pro Ile Val Gly Ala 
            580                 585                 590         


Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp 
        595                 600                 605             


Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly 
    610                 615                 620                 


Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro 
625                 630                 635                 640 


Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro 
                645                 650                 655     


Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser 
            660                 665                 670         


Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn 
        675                 680                 685             


Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys 
    690                 695                 700                 


Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Thr Tyr Ser Glu 
705                 710                 715                 720 


Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Ser Leu 
                725                 730             


<210>  416
<211>  3113
<212>  DNA
<213>  Adeno-associated virus

<400>  416
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcgtccg      180

cccagatcga tcccaccccc gtgatcgtca cttccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttaca agaccggatg ttcaaatttg      300

aactcacccg ccgtctggag catgactttg gcaaggtgac aaagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

agacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgccattcat catctgctgg ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaggcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc cgacgccgag     1140

tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagacccat agaatccccc gactcctcca cgggcatcgg caagaaaggc     1320

cagcagcccg ctaaaaagaa gctcaacttt gggcagactg gcgactcaga gtcagtgccc     1380

gaccctcaac caatcggaga accccccgca ggcccctctg gtctgggatc tggtacaatg     1440

gctgcaggcg gtggcgctcc aatggcagac aataacgaag gcgccgacgg agtgggtagt     1500

tcctcaggaa attggcattg cgattccaca tggctgggcg acagagtcat caccaccagc     1560

acccgaacct gggccctccc cacctacaac aaccacctct acaagcaaat ctccaacggg     1620

acatcgggag gaagcaccaa cgacaacacc tacttcggct acagcacccc ctgggggtat     1680

tttgacttta acagattcca ctgccacttc tcaccacgtg actggcagcg actcatcaac     1740

aacaactggg gattccggcc caagagactc aacttcaagc tcttcaacat ccaggtcaag     1800

gaggtcacgc agaatgaagg caccaagacc atcgccaata accttaccag cacgattcag     1860

gtctttacgg actcggaata ccagctcccg tacgtcctcg gctctgcgca ccagggctgc     1920

ctgcctccgt tcccggcgga cgtcttcatg attcctcagt acgggtacct gactctgaac     1980

aacggcagtc aggccgtggg ccgttcctcc ttctactgcc tggagtactt tccttctcaa     2040

atgctgagaa cgggcaacaa ctttgagttc agctaccagt ttgaggacgt gccttttcac     2100

agcagctatg cgcacagcca aagcctggac cggctgatga accccctcat cgaccagtac     2160

ctgtactacc tgtctcggac tcagtccacg ggaggtaccg caggaactca gcagttgcta     2220

ttttctcagg ccgggcctaa taacatgtcg gctcaggcca aaaactggct acccgggccc     2280

tgctaccggc agcaacgcgt ctccacgaca gtgtcgcaaa ataacaacag caactttgct     2340

tggaccggtg ccaccaagta tcatctgaat ggcagagact ctctggtaaa tcccggtgtc     2400

gctatggcaa cgcacaaggg cgacgaagag cgattttttc catccagcgg agtcttgatg     2460

tttgggaaac agggagctgg aaaagacaac gtggactata gcagcgttat gctaaccagt     2520

gaggaagaaa tcaaaaccac caacccagtg gccacagaac agtacggcgt ggtggccgat     2580

aacctgcaac agcaaaacgc cgctcctatt gtaggggccg tcaacagtca aggagcctta     2640

cctggcatgg tctggcagaa ccgggacgtg tacctgcagg gtcctatctg ggccaagatt     2700

cctcacacgg acggcaactt tcatccttcg ccgctgatgg gaggctttgg actgaaacac     2760

ccgcctcctc agatcctgat taagaataca cctgttcccg cggatcctcc aactaccttc     2820

agtcaagcca agctggcgtc gttcatcacg cagtacagca ccggacaggt cagcgtggaa     2880

attgaatggg agctgcagaa agagaacagc aagcgctgga acccagagat tcagtatact     2940

tccaactact acaaatctac aaatgtggac tttgctgtca atactgaggg tacttattca     3000

gagcctcgcc ccattggcac ccgttacctc acccgtagcc tgtaattgcc tgttaatcaa     3060

taaaccggtt gattcgtttc agttgaactt tggtctctgc gaagggcgaa ttc            3113


<210>  417
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  417

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Pro Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Arg Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  418
<211>  3128
<212>  DNA
<213>  Adeno-associated virus

<400>  418
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcgtccg      180

cccagatcga ccccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttgca ggaccggatg ttcaaatttg      300

aactcacccg ccgtctggag catgactttg gcaaggtgac aaagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

agacatgcga gagaatgaat cagaatttca acatttgctt cacgcgcggg accagagact      660

gttcagaatg tttcccgggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgccattcat catctgctgg ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaggcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc cgacgccgag     1140

tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagaccggt agagccatca ccccagcgtt ctccagactc ctctacgggc     1320

atcggcaaga caggccagca gcccgcgaaa aagagactca actttgggca gactggcgac     1380

tcagagtcag tgcccgaccc tcaaccaatc ggagaacccc ccgcaggccc ctctggtctg     1440

ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa cgaaggcgcc     1500

gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct gggcgacaga     1560

gtcatcacca ccagcacccg aacctgggcc ctccccacct acaacaacca cctctacaag     1620

caaatctcca acgggacatc gggaggaagc accaacgaca acacctactt cggctacagc     1680

accccctggg ggtattttga ctttaacaga ttccactgcc acttctcacc acgtgactgg     1740

cagcgactca tcaacaacaa ctggggattc cggcccaaga gactcaactt caagctcttc     1800

aacatccagg tcaaggaggt cacgcagaat gaaggcacca agaccatcgc caataacctt     1860

accagcacga ttcaggtctt tacggactcg gaataccagc tcccgtacgt cctcggctct     1920

gcgcaccagg gctgcccgcc tccgttcccg gcggacgtct tcatgattcc tcagtacggg     1980

tacctgactc tgaacaacgg cagtcaggcc gtgggccgtt cctccttcta ctgcctggag     2040

tactttcctt ctcaaatgcg gagaacgggc aacaactttg agttcagcta ccagtttgag     2100

gacgtgcctt ttcacagcag ctacgcgcat agccaaagcc tggaccggct gatgaacccc     2160

ctcatcgacc agtacctgta ctacctgtct cggactcagt ccacgggagg taccgcagga     2220

actcagcagt tgctattttc tcaggccggg cctaataaca tgtcggctca ggccaaaaac     2280

tggctacccg ggccctgcta ccggcagcaa cgcgtctcca cgacactgtc gcaaaataac     2340

aacagcaact ttgcttggac cggtgccacc aagtatcatc tgaatggcag agactctctg     2400

gtaaatcccg gtgtcgctat ggcaacgcac aaggacgacg aagagcgatt ttttccatcc     2460

agcggagtct tgatgtttgg gaaacaggga gctggaaaag acaacgtgga ctatagcagc     2520

gttatgctaa ccagtgagga agaaatcaaa accaccaacc cagtggccac agaacagtac     2580

ggcgtggtgg ccgataacct gcaacagcaa aacgccgctc ctattgtagg ggccgtcaac     2640

agtcaaggag ccttacctgg catggtctgg cagaaccggg acgtgtacct gcagggtcct     2700

atctgggcca agattcctca cacggacggc aactttcatc cttcgccgct gatgggaggc     2760

tttggactga aacacccgcc tcctcagatc ctgattaaga atacacctgt tcccgcggat     2820

cctccaacta ccttcagtca agccaagctg gcgtcgttca tcacgcagta cagcaccgga     2880

caggtcagcg tggaaattga atgggagctg cagaaagaga acagcaagcg ctggaaccca     2940

gagattcagt atacttccaa ctactacaaa tctacaaatg tggactttgc tgtcaatact     3000

gagggtactt attcagagcc tcgccccatt ggcacccgtt acctcacccg taacctgtaa     3060

ttgcctgtta atcaataaac cggttaattc gtttcagttg aactttggtc tctgcgaagg     3120

gcgaattc                                                              3128


<210>  419
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  419

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Pro Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Gly Ala 
            580                 585                 590         


Pro Ile Val Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  420
<211>  1933
<212>  DNA
<213>  Adeno-associated virus


<220>
<221>  modified_base
<222>  (1302)..(1302)
<223>  n = a, c, t, or g

<220>
<221>  misc_feature
<222>  (1302)..(1302)
<223>  n is a, c, g, or t

<400>  420
caaggcctac gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc       60

cgacgccgag tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg      120

agcagtcttc caggccaaaa agcgggttct cgaacctctt ggtctggttg agacgccagc      180

taagacggca cctggaaaga agcgaccggt agactcgcca gactccacct cgggcatcgg      240

caagaaaggc cagcagcccg cgaaaaagag actcaacttt gggcagactg gcgactcaga      300

gtcagtcccc gaccctcaac caatcggaga accaccagca ggcccctctg gtctgggatc      360

tggtacaatg gctgcaggcg gtggcgcacc aatggctgac aataacgagg gcgccgacgg      420

agtgggtaat gcctcaggaa attggcattg cgattccaca tggctgggcg acagagtcat      480

caccaccagc acccgaacct gggccctgcc cacctacaac aaccacctct acaagcaaat      540

ctccagtcag tcagcaggga gcaccaacga taacgtctat ttcggctaca gcaccccctg      600

ggggtatttt gacttcaaca gattccattg ccacttctca ccacgtgact ggcagcgact      660

tatcaacaac aactggggat tccggcccaa gaagctcaac ttcaagctct tcaacatcca      720

ggtcaaggag gtcacgacga atgacggtgt cacaaccatc gctaataacc ttaccagcac      780

ggttcaggtc ttttcggact cggaatatca actgccgtac gtcctcggct ccgcgcacca      840

gggctgcctg cctccgttcc cggcagacgt gttcatgatt ccgcagtacg gatacctgac      900

tctgaacaat ggcagccaat cggtaggccg ttcctccttc tactgcctgg agtactttcc      960

ttctcagatg ctgagaacgg gcaacaactt cacctttagc tacaccttcg aggacgtgcc     1020

tttccacagc agctacgcgc acagccagag tctggaccgg ctgatgaatc ccctcatcga     1080

ccagtacctg tactacttgg ccagaacaca gagcaacgca ggaggtactg ctggcaatcg     1140

ggaactgcag ttttatcagg gcggacctac caccatggcc gaacaagcaa agaactggct     1200

gcccggacct tgcttccggc aacagagagt atccaagacg ctggatcaaa ataacaacag     1260

caactttgcc tggactggtg ccacaaaata ccatttaaat gnaagaaatt cattggttaa     1320

tcccggtgtc gccatggcaa cccacaagga cgacgaggaa cgcttcttcc cttcgagcgg     1380

agttctaatt tttggcaaaa ctggagcagc taataaaact acattagaaa acgtgctcat     1440

gacaaatgaa gaagaaattc gtcctaccaa cccggtagct accgaggaat acgggattgt     1500

aagcagcaac ttgcaggcgg ctagcaccgc agcccagaca caagttgtta acaaccaggg     1560

agccttacct ggcatggtct ggcagaaccg ggacgtgtac ctgcaaggtc ccatttgggc     1620

caagattcct cacacggacg gcaactttca cccgtctcct ctaatgggtg gctttggact     1680

gaaacacccg cctccccaga tcctgatcaa aaacacaccg gtacctgcta atcctccaga     1740

agtgtttact cctgccaagt ttgcttcctt catcacgcag tacagcaccg ggcaagtcag     1800

cgttgagatc gagtgggagc tgcagaaaga gaacagcaag cgctggaacc cagagattca     1860

gtacacctcc aactttgaca aacagactgg agtggacttt gctgttgaca gccagggtgt     1920

ttactctgag cct                                                        1933


<210>  421
<211>  733
<212>  PRT
<213>  Adeno-associated virus

<400>  421

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Leu Glu Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly Lys 
145                 150                 155                 160 


Lys Gly Lys Gln Pro Ala Lys Lys Arg Leu Asn Phe Glu Glu Asp Thr 
                165                 170                 175     


Gly Ala Gly Asp Gly Pro Pro Glu Gly Ser Asp Thr Ser Ala Met Ser 
            180                 185                 190         


Ser Asp Ile Glu Met Arg Ala Ala Pro Gly Gly Asn Ala Val Asp Ala 
        195                 200                 205             


Gly Gln Gly Ser Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys 
    210                 215                 220                 


Asp Ser Thr Trp Ser Glu Gly Lys Val Thr Thr Thr Ser Thr Arg Thr 
225                 230                 235                 240 


Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Leu Arg Leu Gly Thr 
                245                 250                 255     


Thr Ser Asn Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Asn Trp Gly Leu Arg Pro Lys Ala Met Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu 
305                 310                 315                 320 


Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp 
                325                 330                 335     


Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser 
            340                 345                 350         


Leu Ser Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Cys Gly Ile Val Thr Gly Glu Asn Gln Asn Gln Thr Asp Arg Asn Ala 
    370                 375                 380                 


Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Met Ala Tyr Asn Phe Gly Lys Val Pro Phe His Ser Met 
                405                 410                 415     


Tyr Ala Tyr Ser Gln Ser Pro Asp Arg Leu Met Asn Pro Leu Leu Asp 
            420                 425                 430         


Gln Tyr Leu Trp His Leu Gln Ser Thr Thr Ser Gly Glu Thr Leu Asn 
        435                 440                 445             


Gln Gly Asn Ala Ala Thr Thr Phe Gly Lys Ile Arg Ser Gly Asp Phe 
    450                 455                 460                 


Ala Phe Tyr Arg Lys Asn Trp Leu Pro Gly Pro Cys Val Lys Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Thr Ala Ser Gln Asn Tyr Lys Ile Pro Ala Ser Gly 
                485                 490                 495     


Gly Asn Ala Leu Leu Lys Tyr Asp Thr His Tyr Thr Leu Asn Asn Arg 
            500                 505                 510         


Trp Ser Asn Ile Ala Pro Gly Pro Pro Met Ala Thr Ala Gly Pro Ser 
        515                 520                 525             


Asp Gly Asp Phe Ser Asn Ala Gln Leu Ile Phe Pro Gly Pro Ser Val 
    530                 535                 540                 


Thr Gly Asn Thr Thr Thr Ser Ala Asn Asn Leu Leu Phe Thr Ser Glu 
545                 550                 555                 560 


Glu Glu Ile Ala Ala Thr Asn Pro Arg Asp Thr Asp Met Phe Gly Gln 
                565                 570                 575     


Ile Ala Asp Asn Asn Gln Asn Ala Thr Thr Ala Pro Ile Thr Gly Asn 
            580                 585                 590         


Val Thr Ala Met Gly Val Leu Pro Gly Met Val Trp Gln Asn Arg Asp 
        595                 600                 605             


Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His Ala Asp Gly 
    610                 615                 620                 


His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys His Pro 
625                 630                 635                 640 


Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Ala 
                645                 650                 655     


Thr Thr Phe Thr Ala Ala Arg Val Asp Ser Phe Ile Thr Gln Tyr Ser 
            660                 665                 670         


Thr Gly Gln Val Ala Val Gln Ile Glu Trp Glu Ile Glu Lys Glu Arg 
        675                 680                 685             


Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly Asn 
    690                 695                 700                 


Gln Ser Ser Met Leu Trp Ala Pro Asp Thr Thr Gly Lys Tyr Thr Glu 
705                 710                 715                 720 


Pro Arg Val Ile Gly Ser Arg Tyr Leu Thr Asn His Leu 
                725                 730             


<210>  422
<211>  3105
<212>  DNA
<213>  Adeno-associated virus

<400>  422
gaattcgccc ttgctgcgtc aactggacca atgagaactt tcccttcaac gattgcgtcg       60

acaagatggt gatctggtgg gaggagggca agatgaccgc caaggtcgtg gagtccgcca      120

aggccattct gggcggaagc aaggtgcgcg tggaccaaaa gtgcaagtca tcggcccaga      180

tcgaccccac gcccgtgatc gtcacctcca acaccaacat gtgcgccgtg atcgacggga      240

acagcaccac cttcgagcac cagcagccgc tgcaggaccg catgttcaag ttcgagctca      300

cccgccgtct ggagcacgac tttggcaagg tgaccaagca ggaagtcaaa gagttcttcc      360

gctgggctca ggatcacgtg actgaggtgg cgcatgagtt ctacgtcaga aagggcggag      420

ccaccaaaag acccgccccc agtgacgcgg atataagcga gcccaagcgg gcctgcccct      480

cagttgcgga gccatcgacg tcagacgcgg aagcaccggt ggactttgcg gacaggtacc      540

aaaacaaatg ttctcgtcac gcgggcatgc ttcagatgct gtttccctgc aagacatgcg      600

agagaatgaa tcagaatttc aacgtctgct tcacgcacgg ggtcagagac tgctcagagt      660

gcttccccgg cgcgtcagaa tctcaacccg tcgtcagaaa aaagacgtat cagaaactgt      720

gcgcgattca tcatctgctg gggcgggcac ccgagattgc gtgttcggcc cgcgatctcg      780

tcaacgtgga cttggatgac tgtgtttctg agcaataaat gacttaaacc aggtatggct      840

gctgacggtt atcttccaga ttggctcgag gacaacctct ctgagggcat tcgcgagtgg      900

tgggacctga aacctggagc ccccaagccc aaggccaacc agcagaagca ggacgacggc      960

cggggtctgg tgcttcctgg ctacaagtac ctcggaccct tcaacggact cgacaagggg     1020

gagcccgtca acgcggcgga cgcagcggcc ctcgagcacg acaaggccta cgaccagcag     1080

ctcaaagcgg gtgacaatcc gtacctgcgg tataaccacg ccgacgccga gtttcaggag     1140

cgtctgcaag aagatacgtc ttttgggggc aacctcgggc gagcagtctt ccaggccaag     1200

aagagggtac tcgaacctct gggcctggtt gaagaaggtg ctaagacggc tcctggaaag     1260

aagagaccgt tagagtcacc acaagagccc gactcctcct caggaatcgg caaaaaaggc     1320

aaacaaccag ccaaaaagag actcaacttt gaagaggaca ctggagccgg agacggaccc     1380

cctgaaggat cagataccag cgccatgtct tcagacattg aaatgcgtgc agcaccgggc     1440

ggaaatgctg tcgatgcggg acaaggttcc gatggagtgg gtaatgcctc gggtgattgg     1500

cattgcgatt ccacctggtc tgagggcaag gtcacaacaa cctcgaccag aacctgggtc     1560

ttgcccacct acaacaacca cttgtacctg cggctcggaa caacatcaaa cagcaacacc     1620

tacaacggat tctccacccc ctggggatac tttgacttta acagattcca ctgtcacttc     1680

tcaccacgtg actggcaaag actcatcaac aacaactggg gactacgacc aaaagccatg     1740

cgcgttaaaa tcttcaatat ccaagttaag gaggtcacaa cgtcgaacgg cgagactacg     1800

gtcgctaata accttaccag cacggttcag atatttgcgg actcgtcgta tgagctcccg     1860

tacgtgatgg acgctggaca agagggaagt ctgtctcctt tccccaatga cgtcttcatg     1920

gtgcctcaat atggctactg tggcattgtg actggcgaaa atcagaacca gacggacaga     1980

aatgctttct actgcctgga gtattttcct tcacaaatgc tgagaactgg caataacttt     2040

gaaatggctt acaactttgg gaaggtgccg ttccactcaa tgtatgctta cagccagagc     2100

ccggacagac tgatgaatcc cctcctggac cagtacctgt ggcacttaca gtcgaccacc     2160

tctggagaga ctctgaatca aggcaatgca gcaaccacat ttggaaaaat caggagtgga     2220

gactttgcct tttacagaaa gaactggctg cctgggcctt gtgttaaaca gcagagactc     2280

tcaaaaactg ccagtcaaaa ttacaagatt cctgccagcg ggggcaacgc tctgttaaag     2340

tatgacaccc actatacctt aaacaaccgc tggagcaaca tagcgcctgg acctccaatg     2400

gcaacagctg gaccttcaga tggggacttc agcaacgccc agctcatctt ccctggacca     2460

tcagtcaccg gaaacacaac aacctcagca aacaatctgt tgtttacatc agaagaagaa     2520

attgctgcca ccaacccaag agacacggac atgtttggtc agattgctga caataatcag     2580

aatgctacaa ctgctcccat aaccggcaac gtgactgcta tgggagtgct tcctggcatg     2640

gtgtggcaaa acagagacat ttactaccaa gggccaattt gggccaagat cccacacgcg     2700

gacggacatt ttcatccttc accgctaatt ggcggttttg gactgaaaca tccgcctccc     2760

cagatattta tcaaaaacac ccccgtacct gccaatcctg cgacaacctt cactgcagcc     2820

agagtggact ctttcatcac acaatacagc accggccagg tcgctgttca gattgaatgg     2880

gaaatcgaaa aggaacgctc caaacgctgg aatcctgaag tgcagtttac ttcaaactat     2940

gggaaccagt cttctatgtt gtgggctccc gatacaactg ggaagtatac agagccgcgg     3000

gttattggct ctcgttattt gactaatcat ttgtaactgc ctagttaatc aataaaccgt     3060

gtgattcgtt tcagttgaac tttggtctct gcgaagggcg aattc                     3105


<210>  423
<211>  733
<212>  PRT
<213>  Adeno-associated virus

<400>  423

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Leu Glu Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly Lys 
145                 150                 155                 160 


Lys Gly Lys Gln Pro Ala Lys Lys Arg Leu Asn Phe Glu Glu Asp Thr 
                165                 170                 175     


Gly Ala Gly Asp Gly Pro Pro Glu Gly Ser Asp Thr Ser Ala Met Ser 
            180                 185                 190         


Ser Asp Ile Glu Met Arg Ala Ala Pro Gly Gly Asn Ala Val Asp Ala 
        195                 200                 205             


Gly Gln Gly Ser Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys 
    210                 215                 220                 


Asp Ser Thr Trp Ser Glu Gly Lys Val Thr Thr Thr Ser Thr Arg Thr 
225                 230                 235                 240 


Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Leu Arg Leu Gly Thr 
                245                 250                 255     


Thr Ser Asn Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Asn Trp Gly Leu Arg Pro Lys Ala Met Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu 
305                 310                 315                 320 


Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp 
                325                 330                 335     


Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser 
            340                 345                 350         


Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Cys Gly Ile Val Thr Gly Glu Asn Gln Asn Gln Thr Asp Arg Asn Ala 
    370                 375                 380                 


Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Met Ala Tyr Asn Phe Glu Lys Val Pro Phe His Ser Met 
                405                 410                 415     


Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Leu Asp 
            420                 425                 430         


Gln Tyr Leu Trp His Leu Gln Ser Thr Thr Ser Gly Glu Thr Leu Asn 
        435                 440                 445             


Gln Gly Asn Ala Ala Thr Thr Phe Gly Lys Ile Arg Ser Gly Asp Phe 
    450                 455                 460                 


Ala Phe Tyr Arg Lys Asn Trp Leu Pro Gly Pro Cys Val Lys Gln Gln 
465                 470                 475                 480 


Arg Phe Ser Lys Thr Ala Ser Gln Asn Tyr Lys Ile Pro Ala Ser Gly 
                485                 490                 495     


Gly Asn Ala Leu Leu Lys Tyr Asp Thr His Tyr Thr Leu Asn Asn Arg 
            500                 505                 510         


Trp Ser Asn Ile Ala Pro Gly Pro Pro Met Ala Thr Ala Gly Pro Ser 
        515                 520                 525             


Asp Gly Asp Phe Ser Asn Ala Gln Leu Ile Phe Pro Gly Pro Ser Val 
    530                 535                 540                 


Thr Gly Asn Thr Thr Thr Ser Ala Asn Asn Leu Leu Phe Thr Ser Glu 
545                 550                 555                 560 


Glu Glu Ile Ala Ala Thr Asn Pro Arg Asp Thr Asp Met Phe Gly Gln 
                565                 570                 575     


Ile Ala Asp Asn Asn Gln Asn Ala Thr Thr Ala Pro Ile Thr Gly Asn 
            580                 585                 590         


Val Thr Ala Met Gly Val Leu Pro Gly Met Val Trp Gln Asn Arg Asp 
        595                 600                 605             


Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His Ala Asp Gly 
    610                 615                 620                 


His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys His Pro 
625                 630                 635                 640 


Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Ala 
                645                 650                 655     


Thr Thr Phe Thr Ala Ala Arg Val Asp Ser Phe Ile Thr Gln Tyr Ser 
            660                 665                 670         


Thr Gly Gln Val Ala Val Gln Ile Glu Trp Glu Ile Glu Lys Glu Arg 
        675                 680                 685             


Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly Asn 
    690                 695                 700                 


Gln Ser Ser Met Leu Trp Ala Pro Asp Thr Thr Gly Lys Tyr Thr Glu 
705                 710                 715                 720 


Pro Arg Val Ile Gly Ser Arg Tyr Leu Thr Asn His Leu 
                725                 730             


<210>  424
<211>  3105
<212>  DNA
<213>  Adeno-associated virus

<400>  424
gaattcgccc ttgctgcgtc aactggacca atgagaactt tcccttcaac gattgcgtcg       60

acaagatggt gatctggtgg gaggagggca agatgaccgc caaggtcgtg gagtccgcca      120

aggccattct gggcggaagc aaggtgcgcg tggaccaaaa gtgcaagtca tcggcccaga      180

tcgaccccac gcccgtgatc gtcacctcca acaccaacat gtgcgccgtg atcgacggga      240

acagcaccac cttcgagcac cagcagccgc tgcaggaccg catgttcaag ttcgagctca      300

cccgccgtct ggagcacgac tttggcaagg tgaccaagca ggaagtcaaa gagttcttcc      360

gctgggctca ggatcacgtg actgaggtgg cgcatgagtt ctacgtcaga aagggcggag      420

ccaccaaaag acccgccccc agtgacgcgg atataagcga gcccaagcgg gcctgcccct      480

cagttgcgga gccatcgacg tcagacgcgg aagcaccggt ggactttgcg gacaggtacc      540

aaaacaaatg ttctcgtcac gcgggcatgc ttcagatgct gtttccctgc aagacatgcg      600

agagaatgaa tcagaatttc aacgtctgct tcacgcacgg ggtcagagac tgctcagagt      660

gcttccccgg cgcgtcagaa tctcaacccg tcgtcagaaa aaagacgtat cagaaactgt      720

gcgcgattca tcatctgctg gggcgggcac ccgagattgc gtgttcggcc tgcgatctcg      780

tcaacgtgga cttggatgac tgtgtttctg agcaataaat gacttaaacc aggtatggct      840

gctgacggtt atcttccaga ttggctcgag gacaacctct ctgagggcat tcgcgagtgg      900

tgggacctga aacctggagc ccccaagctc aaggccaacc agcagaagca ggacgacggc      960

cggggtctgg tgcttcctgg ctacaagtac ctcggaccct tccacggact cgacaagggg     1020

gagcccgtca acgcggcgga cgcagcggcc ctcgagcacg acaaggccta cgaccagcag     1080

ctcaaagcgg gtgacaatcc gtacctgcgg tataaccacg ccgacgccga gtttcaggag     1140

cgtctgcaag aagatacgtc ttttgggggc aacctcgggc gagcagtctt ccaggccaag     1200

aagagggtac tcgaaccact gggcctggtt gaagaaggtg ctaagacggc tcctggaaag     1260

aagagaccgt tagagtcacc acaagagccc gactcctcct caggaatcgg caaaaaaggc     1320

aaacaaccag ccaaaaagag actcaacttt gaagaggaca ctggagccgg agacggaccc     1380

cctgaaggat cagataccag cgccatgtct tcagacattg aaatgcgtgc agcaccgggc     1440

ggaaatgctg tcgatgcggg acaaggttcc gatggagtgg gtaatgcctc gggtgattgg     1500

cattgcgatt ccacctggtc tgagggcaag gtcacaacaa cctcgaccag aacctgggtc     1560

ttgcccacct acaacaacca cttgtacctg cggctcggaa caacatcaaa cagcaacacc     1620

tacaacggat tctccacccc ctggggatac tttgacttta acagattcca ctgtcacttc     1680

tcaccacgtg actggcaaag actcatcaac aacaactggg gactacgacc aaaagccatg     1740

cgcgttaaaa tcttcaatat ccaagttaag gaggtcacaa cgtcgaacgg cgagactacg     1800

gtcgctaata accttaccag cacggttcag atatttgcgg actcgtcgta tgagctcccg     1860

tacgtgatgg acgctggaca agagggaagt ctgcctcctt tccccaatga cgtcttcatg     1920

gtgcctcaat atggctactg tggcattgtg actggcgaaa atcagaacca gacggacaga     1980

aatgctttct actgcctgga gtattttcct tcacaaatgc tgagaactgg caataacttt     2040

gaaatggctt acaactttga gaaggtgccg ttccactcaa tgtatgctca cagccagagc     2100

ctggacagac tgatgaatcc cctcctggac cagtacctgt ggcacttaca gtcgaccacc     2160

tctggagaga ctctgaatca aggcaatgca gcaaccacat ttggaaaaat caggagtgga     2220

gactttgcct tttacagaaa gaactggctg cctgggcctt gtgttaaaca gcagagattc     2280

tcaaaaactg ccagtcaaaa ttacaagatt cctgccagcg ggggcaacgc tctgttaaag     2340

tatgacaccc actatacctt aaacaaccgc tggagcaaca tagcgcctgg acctccaatg     2400

gcaacagctg gaccttcaga tggggacttc agcaacgccc agctcatctt ccctggacca     2460

tcagtcaccg gaaacacaac aacctcagca aacaatctgt tgtttacatc agaaggagaa     2520

attgctgcca ccaacccaag agacacggac atgtttggtc agattgctga caataatcag     2580

aatgctacaa ctgctcccat aaccggcaac gtgactgcta tgggagtgct tcctggcatg     2640

gtgtggcaaa acagagacat ttactaccaa gggccaattt gggccaagat cccacacgcg     2700

gacggacatt ttcatccttc accgctaatt ggcggttttg gactgaaaca tccgcctccc     2760

cagatattta tcaaaaacac ccccgtacct gccaatcctg cgacaacctt cactgcagcc     2820

agagtggact ctttcatcac acaatacagc accggccagg tcgctgttca gattgaatgg     2880

gaaatcgaaa aggaacgctc caaacgccgg aatcctgaag tgcagtttac ttcaaactat     2940

gggaaccagt cttctatgtt gtgggctccc gatacaactg ggaagtatac agagccgcgg     3000

gttattggct ctcgttattt gactaatcat ttgtaactgc ctagttaatc aataaaccgt     3060

gtgattcgtt tcagttgaac tttggtctct gcgaagggcg aattc                     3105


<210>  425
<211>  733
<212>  PRT
<213>  Adeno-associated virus

<400>  425

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Glu Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Leu Glu Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly Lys 
145                 150                 155                 160 


Lys Gly Lys Gln Pro Ala Lys Lys Arg Leu Asn Phe Glu Glu Asp Thr 
                165                 170                 175     


Gly Ala Gly Asp Gly Pro Pro Glu Gly Ser Asp Thr Ser Ala Met Ser 
            180                 185                 190         


Ser Asp Ile Glu Met Arg Ala Ala Pro Gly Gly Asn Ala Val Asp Ala 
        195                 200                 205             


Gly Gln Gly Ser Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys 
    210                 215                 220                 


Asp Ser Thr Trp Ser Glu Gly Lys Val Thr Thr Thr Ser Thr Arg Thr 
225                 230                 235                 240 


Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Leu Arg Leu Gly Thr 
                245                 250                 255     


Thr Ser Asn Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Asn Trp Gly Leu Arg Pro Lys Ala Met Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu 
305                 310                 315                 320 


Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp 
                325                 330                 335     


Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser 
            340                 345                 350         


Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Cys Gly Ile Val Thr Gly Glu Asn Gln Asn Gln Thr Asp Arg Asn Ala 
    370                 375                 380                 


Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Thr Ala Tyr Asn Phe Glu Lys Val Pro Phe His Ser Met 
                405                 410                 415     


Tyr Ala His Ser Gln Ser Leu Asp Gly Leu Met Asn Pro Leu Leu Asp 
            420                 425                 430         


Gln Tyr Leu Trp His Leu Gln Ser Thr Thr Ser Gly Glu Thr Leu Asn 
        435                 440                 445             


Gln Gly Asn Ala Ala Thr Thr Phe Gly Lys Ile Arg Ser Gly Asp Phe 
    450                 455                 460                 


Ala Phe Tyr Arg Lys Asn Trp Leu Pro Gly Pro Cys Val Lys Gln Gln 
465                 470                 475                 480 


Arg Phe Ser Lys Thr Ala Ser Gln Asn Tyr Lys Ile Pro Ala Ser Gly 
                485                 490                 495     


Gly Asn Ala Leu Leu Lys Tyr Asp Thr His Tyr Thr Leu Asn Asn Arg 
            500                 505                 510         


Trp Ser Asn Ile Ala Pro Gly Pro Pro Met Ala Thr Ala Gly Pro Ser 
        515                 520                 525             


Asp Gly Asp Phe Ser Asn Ala Gln Leu Ile Phe Pro Gly Pro Ser Val 
    530                 535                 540                 


Thr Gly Asn Thr Thr Thr Ser Ala Asn Asn Leu Leu Phe Thr Ser Glu 
545                 550                 555                 560 


Glu Glu Ile Ala Ala Thr Asn Pro Arg Asp Thr Asp Met Phe Gly Gln 
                565                 570                 575     


Ile Ala Asp Asn Asn Gln Asn Ala Thr Thr Ala Pro Ile Thr Gly Asn 
            580                 585                 590         


Val Thr Ala Met Gly Val Leu Pro Gly Met Val Trp Gln Asn Arg Asp 
        595                 600                 605             


Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His Ala Asp Gly 
    610                 615                 620                 


His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys His Pro 
625                 630                 635                 640 


Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Tyr Pro Ala 
                645                 650                 655     


Thr Thr Phe Thr Ala Ala Arg Val Asp Ser Phe Ile Thr Gln Tyr Ser 
            660                 665                 670         


Thr Gly Gln Val Ala Val Gln Ile Glu Trp Glu Ile Glu Lys Glu Arg 
        675                 680                 685             


Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn Cys Gly Asn 
    690                 695                 700                 


Gln Ser Ser Met Leu Trp Ala Pro Asp Thr Thr Gly Lys Tyr Thr Glu 
705                 710                 715                 720 


Pro Arg Val Ile Gly Ser Arg Tyr Leu Thr Asn His Leu 
                725                 730             


<210>  426
<211>  3105
<212>  DNA
<213>  Adeno-associated virus

<400>  426
gaattcgccc ttcgcagaga ccaaagttca actgaaacga atcacacggt ttattgatta       60

actaggcagt tacaaatgat tagtcaaata acgagagcca ataacccgcg gctctgtata      120

cttcccagtt gtatcgggag cccacaacat agaagactgg ttcccacagt ttgaagtaaa      180

ctgcacttca ggattccagc gtttggagcg ttccttttcg atttcccatt caatctgaac      240

agcgacctgg ccggtgctgt attgtgtgat gaaagagtcc actctggctg cagtgaaggt      300

tgtcgcagga taggcaggta cgggggtgtt tttgataaat atctggggag gcggatgttt      360

cagtccaaaa ccgccaatta gcggtgaagg atgaaaatgt ccgtccgcgt gtgggatctt      420

ggcccaaatt ggcccttggt agtaaatgtc tctgttttgc cacaccatgc caggaagcac      480

tcccatagca gtcacgttgc cggttatggg agcagttgta gcattctgat tattgtcagc      540

aatctgacca aacatgtccg tgtctcttgg gttggtggca gcaatttctt cttctgatgt      600

aaacaacaga ttgtttgctg aggttgttgt gtttccggtg actgatggtc cagggaagat      660

gagctgggcg ttgctgaagt ccccatctga aggtccagct gttgccattg gaggtccagg      720

cgctatgttg ctccagcggt tgtttaaggt atagtgggtg tcatacttta acagagcgtt      780

gcccccgctg gcaggaatct tgtaattttg actggcagtt tttgagaatc tctgctgttt      840

aacacaaggc ccaggcagcc agttctttct gtaaaaggca aagtctccac tcctgatttt      900

tccaaatgtg gttgctgcat tgccttgatt cagagtctct ccagaggtgg tcgactgtaa      960

gtgccacagg tactggtcca ggaggggatt catcagtccg tccaggctct ggctgtgagc     1020

atacattgag tggaacggca ccttctcaaa gttgtaagcc gtttcaaagt tattgccagt     1080

tctcagcatt tgtgaaggaa aatactccag gcagtagaaa gcatttctgt ccgtctggtt     1140

ctgattttcg ccagtcacaa tgccacagta gccatattga ggcaccatga agacgtcatt     1200

ggggaaagga ggcagacttc cctcttgtcc agcgtccatc acgtacggga gctcatacga     1260

cgagtccgca aatatctgaa ccgtgctggt aaggttatta gcgaccgtag tctcgccgtt     1320

cgacgttgtg acctccttaa cttggatatt gaagatttta acgcgcatgg cttttggtcg     1380

tagtccccag ttgttgttga tgagtctttg ccagtcacgt ggtgagaagt gacagtggaa     1440

tctgttaaag tcaaagtatc cccagggggt ggagaatccg ttgtaggtgt tgctgtttga     1500

tgttgttccg agccgcaggt acaagtggtt gttgtaggtg ggcaagaccc aggttctggt     1560

cgaggttgtt gtgaccttgc cctcagacca ggtggaatcg caatgccaat cacccgaggc     1620

attacccact ccatcggaac cttgtcccgc atcgacagca tttccgcccg gtgctgcacg     1680

catttcaatg tctgaagaca tggcgctggt atctgatcct tcagggggtc cgtctccggc     1740

tccagtgtcc tcttcaaagt tgagtctctt tttggctggt tgtttgcctt ttttgccgat     1800

tcctgaggag gagtcgggct cttgtggtga ctctaacggt ctcttctttc caggagccgt     1860

cttagcacct tcttcaacca ggcccagagg ttcgagtacc ctcttcttgg cctggaagac     1920

tgctcgcccg aggttgcccc caaaagacgt atcttcttgc agacgctcct gaaactcggc     1980

gtcggcgtgg ttataccgca ggtacggatt gtcacccgct ttgagctgct ggtcgtaggc     2040

cttgtcgtgc tcgagggccg ctgcgtccgc cgcgttgacg ggctccccct tgtcgagtcc     2100

gttgaagggt ccgaggtact cgtagccagg aagcaccaga ccccggccgt cgtcctgctt     2160

ctgctggttg gccttgggct tgggggctcc aggtttcagg tcccaccact cgcgaatgcc     2220

ctcagagagg ttgtcctcga gccaatctgg aagataaccg tcagcagcca tacctggttt     2280

aagtcattta ttgctcagaa acacagtcat ccaagtccac gttgacgaga tcgcaggccg     2340

aacacgcaat ctcgggtgcc cgccccagca gatgatgaat cgcgcacagt ttctgatacg     2400

tcttttttct gacgacgggt tgagattctg acgcgccggg gaagcactct gagcagtctc     2460

tgaccccgtg cgtgaagcag acgttgaaat tctgattcat tctctcgcat gtcttgcagg     2520

gaaacagcat ctgaagcatg cccgcgtgac gagaacattt gttttggtac ctgtccgcaa     2580

ggtccaccgg tgcttccgcg tctgacgtcg atggctccgc aactgagggg caggcccgct     2640

tgggctcgct tatatccgcg tcactggggg cgggtctttt ggtggctccg ccctttctga     2700

cgtagaactc atgcgccacc tcagtcacgt gatcctgagc ccagcggaag aactctttga     2760

cttcctgctt ggtcaccttg ccaaagtcgt gctccagacg gcgggtgagc tcgaacttga     2820

acatgcggtc ctgcagcggc tgctggtgct cgaaggtggt gctgttcccg tcgatcacgg     2880

cgcacatgtt ggtgttggag gtgacgatca cgggcgtggg gtcgatctgg gccgatgact     2940

tgcacttttg gtccacgcgc accttgcttc cgcccagaat ggccttggcg gactccacga     3000

ccttggcggt catcttgccc tcctcccacc agatcaccat cttgtcgacg caatcgttga     3060

agggaaagtt ctcattggtc cagttgacgc agcaagggcg aattc                     3105


<210>  427
<211>  729
<212>  PRT
<213>  Adeno-associated virus

<400>  427

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Asp Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Ser Ser Ser Gly Ala Thr Asn Asp Asn His Tyr Phe Gly Tyr 
            260                 265                 270         


Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe 
        275                 280                 285             


Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg 
    290                 295                 300                 


Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val 
305                 310                 315                 320 


Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser Phe Glu Asp Val Pro 
                405                 410                 415     


Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn 
            420                 425                 430         


Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr 
        435                 440                 445             


Thr Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr 
    450                 455                 460                 


Met Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln 
465                 470                 475                 480 


Gln Gly Leu Ser Lys Asn Leu Asp Phe Asn Asn Asn Ser Asn Phe Ala 
                485                 490                 495     


Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr 
            500                 505                 510         


Asn Pro Gly Ile Pro Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe 
        515                 520                 525             


Phe Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn 
    530                 535                 540                 


Lys Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys 
545                 550                 555                 560 


Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn 
                565                 570                 575     


Leu Gln Pro Ser Thr Ala Gly Pro Gln Ser Gln Thr Ile Asn Ser Gln 
            580                 585                 590         


Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln 
        595                 600                 605             


Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro 
    610                 615                 620                 


Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile 
625                 630                 635                 640 


Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr 
                645                 650                 655     


Pro Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
            660                 665                 670         


Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp 
        675                 680                 685             


Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val 
    690                 695                 700                 


Glu Phe Ala Val Asn Pro Asp Gly Val Tyr Thr Glu Pro Arg Pro Ile 
705                 710                 715                 720 


Gly Thr Arg Tyr Leu Pro Arg Asn Leu 
                725                 


<210>  428
<211>  3094
<212>  DNA
<213>  Adeno-associated virus

<400>  428
gaattcgccc ttgctgcgtc aactggacca agagaacttt cccttcaacg attgcgtcga       60

caagatggtg atctggtggg aggagggcaa gatgacggcc aaggtcgtgg agtccgccaa      120

agccattctg ggcggaagca aggtgcgcgt cgaccaaaag tgcaagtcct cggcccagat      180

cgatcccacc cccgtgatcg tcacctccaa caccaacatg tgcgccgtga tcgacgggaa      240

cagcaccacc ttcgagcacc agcagccgtt gcaggaccgg atgttcaaat ttgaactcac      300

ccgccgtctg gaacacgact ttggcaaggt gaccaagcag gaagtcaaag agttcttccg      360

ctgggctagt gatcacgtga ctgaggtgac gcatgagttc tacgtcagaa agggcggagc      420

cagcaaaaga cccgcccccg atgacgcgga tataagcgag cccaagcggg cctgtccctc      480

agtcacggac ccatcgacgt cagacgcgga aggagctccg gtggactttg ccgacaggta      540

ccaaaacaaa tgttctcgtc acgcgggcat gcttcagatg ctgtttccct gcaaaacgtg      600

cgagagaatg aatcagaatt tcaacatttg cttcacgcac ggggtcagag actgtttaga      660

atgtttcccc ggcgtgtcag aatctcaacc ggtcgtcaga aaaaagacgt atcggaagct      720

gtgtgcgatt catcatctgc tggggcgggc acccgagatt gcttgctcgg cctgcgacct      780

ggtcaacgtg gacctggacg actgtgtttc tgagcaataa atgacttaaa ccgggtatgg      840

ctgccgatgg ttatcttcca gattggctcg aggacaacct ctctgagggc attcgcgagt      900

ggtgggacct gaaacctgga gccccgaaac ccaaagccaa ccagcaaaag caggacgacg      960

gccggggtct ggtgcttcct ggctacaagt acctcggacc cttcaacgga ctcgacaagg     1020

gggagcccgt caacgcggcg gacgcagcgg ccctcgagca cgacaaggcc tacgaccagc     1080

agctcaaagc gggtgacaat ccgtacctgc ggtataacca cgccgacgcc gagtttcagg     1140

agcgtctgca agaagatacg tcatttgggg gcaacctcgg gcgagcagtc ttccaggcca     1200

agaagcgggt tctcgaacct ctcggtctgg ttgaggaagg cgctaagacg gctcctggaa     1260

agaagagacc catagactct ccagactcct ccacgggcat cggcaaaaaa ggccagcagc     1320

ccgctaaaaa gaagctcaat tttggtcaga ctggcgactc agagtcagtc cccgaccctc     1380

aacctcttgg agaacctcca gcagcgccct ctagtgtggg atctggtaca atggctgcag     1440

gcggtggcgc accaatggca gacaataacg aaggtgccga cggagtgggt aatgcctcag     1500

gaaattggca ttgcgattcc acatggctgg gcgacagagt catcaccacc agcaccagaa     1560

cctgggccct ccccacctac aacaaccacc tctacaagca aatctccagc agcagctcag     1620

gagccaccaa tgacaaccac tacttcggct acagcacccc ctgggggtat tttgacttta     1680

acagattcca ctgccacttc tcaccacgtg actggcagcg actcatcaac aacaactggg     1740

gattccggcc caagaagctg cggttcaagc tcttcaacat ccaggtcaag gaggtcacaa     1800

cgaatgacgg cgtcacgacc atcgctaata accttaccag cacggttcag gtcttctcgg     1860

actcggaata ccagctgccg tacgtcctcg gctctgcgca ccagggctgc ctgcctccgt     1920

tcccggcgga cgtcttcatg attcctcagt acggctacct gactctgaac aacggcagcc     1980

aatcggtggg ccgttcctcc ttctactgcc tggaatattt cccctctcaa atgctgagaa     2040

cgggcaacaa ctttgagttc agttacagct tcgaggacgt gcctttccac agcagctacg     2100

cgcacagcca gagcctagac cggctgatga accctctcat cgaccagtac ctgtactacc     2160

tggcccggac ccagagcacc acgggttcca ccagggaact gcaatttcat caagctgggc     2220

ccaatactat ggccgagcag tcaaagaact ggctgcctgg accctgctat aggcaacagg     2280

gactgtcaaa gaacttggac tttaacaaca acagcaattt tgcctggact gctgccacta     2340

aatatcatct gaatggcaga aactctttga ccaatcctgg cattcccatg gcaaccaaca     2400

aggatgatga ggaccagttc tttcccatca acggggtact ggtttttggc aagacgggag     2460

ctgccaacaa aactacgctg gaaaacgttc tgatgaccag cgaggaggag atcaagacca     2520

ctaaccctgt ggctacagaa gaatacggtg tggtctccag caacctgcag ccgtctacag     2580

ccgggcctca atcacagact atcaacagcc agggagcact gcctggcatg gtctggcaga     2640

accgggacgt gtatctgcag ggtcccatct gggccaaaat tcctcacacg gatggcaact     2700

ttcacccgtc tcctctgatg ggcggttttg gactcaaaca cccgcctcca cagatcctga     2760

tcaaaaacac acctgtacct gctaatcctc cggaggtgtt tactcctgcc aagtttgcct     2820

ccttcatcac gcagtacagc accggacaag tcagcgtgga aatcgagtgg gagctgcaga     2880

aagaaaacag caagcgctgg aacccagaaa ttcagtatac ttccaattat gccaagtcta     2940

ataatgttga atttgctgtg aaccctgatg gtgtttatac tgagcctcgc cccattggca     3000

ctcgttacct cccccgtaat ctgtaattgc ttgttaatca ataaaccggt tgattcgttt     3060

cagttgaact ttggtctctg cgaagggcga attc                                 3094


<210>  429
<211>  1458
<212>  PRT
<213>  Adeno-associated virus

<400>  429

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Asp Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Thr Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Ser Ser Ser Gly Ala Thr Asn Asp Asn His Tyr Phe Gly Tyr 
            260                 265                 270         


Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe 
        275                 280                 285             


Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg 
    290                 295                 300                 


Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val 
305                 310                 315                 320 


Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser Phe Glu Asp Val Pro 
                405                 410                 415     


Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn 
            420                 425                 430         


Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr 
        435                 440                 445             


Thr Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr 
    450                 455                 460                 


Met Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln 
465                 470                 475                 480 


Gln Arg Leu Ser Lys Asn Leu Asp Phe Asn Asn Asn Ser Asn Phe Ala 
                485                 490                 495     


Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr 
            500                 505                 510         


Asn Pro Gly Ile Pro Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe 
        515                 520                 525             


Phe Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn 
    530                 535                 540                 


Lys Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys 
545                 550                 555                 560 


Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn 
                565                 570                 575     


Leu Gln Ser Ser Thr Ala Gly Pro Gln Ser Gln Thr Ile Asn Ser Gln 
            580                 585                 590         


Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln 
        595                 600                 605             


Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro 
    610                 615                 620                 


Ser Pro Leu Met Gly Gly Phe Gly Leu Glu His Pro Pro Pro Gln Ile 
625                 630                 635                 640 


Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr 
                645                 650                 655     


Pro Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
            660                 665                 670         


Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp 
        675                 680                 685             


Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val 
    690                 695                 700                 


Glu Phe Ala Val Asn Pro Asp Gly Val Tyr Thr Glu Pro Arg Pro Ile 
705                 710                 715                 720 


Gly Thr Arg Tyr Leu Thr Arg Asn Leu Met Ala Ala Asp Gly Tyr Leu 
                725                 730                 735     


Pro Asp Trp Leu Glu Asp Asn Leu Ser Glu Gly Ile Arg Glu Trp Trp 
            740                 745                 750         


Asp Leu Lys Pro Gly Ala Pro Lys Pro Lys Ala Asn Gln Gln Lys Gln 
        755                 760                 765             


Asp Asp Gly Arg Gly Leu Val Leu Pro Gly Tyr Lys Tyr Leu Gly Pro 
    770                 775                 780                 


Phe Asn Gly Leu Asp Lys Gly Glu Pro Val Asn Ala Ala Asp Ala Ala 
785                 790                 795                 800 


Ala Leu Glu His Asp Lys Ala Tyr Asp Gln Gln Leu Lys Ala Gly Asp 
                805                 810                 815     


Asn Pro Tyr Leu Arg Tyr Asn His Ala Asp Ala Glu Phe Gln Glu Arg 
            820                 825                 830         


Leu Gln Glu Asp Thr Ser Phe Gly Gly Asn Leu Gly Arg Ala Val Phe 
        835                 840                 845             


Gln Ala Lys Lys Arg Val Leu Glu Pro Leu Gly Leu Val Glu Glu Gly 
    850                 855                 860                 


Ala Lys Thr Ala Pro Gly Lys Lys Arg Pro Ile Gly Ser Pro Asp Ser 
865                 870                 875                 880 


Ser Thr Gly Ile Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Lys Leu 
                885                 890                 895     


Asn Phe Gly Gln Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro 
            900                 905                 910         


Leu Gly Glu Pro Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met 
        915                 920                 925             


Ala Ala Gly Gly Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp 
    930                 935                 940                 


Gly Val Gly Asn Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu 
945                 950                 955                 960 


Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr 
                965                 970                 975     


Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Ser Ser Ser Ser Gly Ala 
            980                 985                 990         


Thr Asn Asp Asn His Tyr Phe Gly  Tyr Ser Thr Pro Trp  Gly Tyr Phe 
        995                 1000                 1005             


Asp Phe  Asn Arg Phe His Cys  His Phe Ser Pro Arg  Asp Trp Gln 
    1010                 1015                 1020             


Arg Leu  Ile Asn Asn Asn Trp  Gly Phe Arg Pro Lys  Lys Leu Arg 
    1025                 1030                 1035             


Phe Lys  Leu Leu Asn Ile Gln  Val Lys Glu Val Thr  Thr Asn Asp 
    1040                 1045                 1050             


Gly Val  Thr Thr Ile Ala Asn  Asn Leu Thr Ser Thr  Val Gln Val 
    1055                 1060                 1065             


Phe Ser  Asp Ser Glu Tyr Gln  Leu Pro Tyr Val Leu  Gly Ser Ala 
    1070                 1075                 1080             


His Gln  Gly Cys Leu Pro Pro  Phe Pro Ala Asp Val  Phe Met Ile 
    1085                 1090                 1095             


Pro Gln  Tyr Gly Tyr Leu Thr  Leu Asp Asn Gly Ser  Gln Ser Val 
    1100                 1105                 1110             


Gly Arg  Ser Ser Phe Tyr Cys  Leu Glu Tyr Phe Pro  Ser Gln Met 
    1115                 1120                 1125             


Leu Arg  Thr Gly Asn Asn Phe  Glu Phe Ser Tyr Ser  Phe Glu Asp 
    1130                 1135                 1140             


Val Pro  Phe His Ser Ser Tyr  Ala His Ser Gln Ser  Leu Asp Arg 
    1145                 1150                 1155             


Leu Met  Asn Pro Leu Ile Asp  Gln Tyr Leu Tyr Tyr  Leu Ala Arg 
    1160                 1165                 1170             


Thr Gln  Ser Thr Thr Gly Ser  Thr Arg Glu Leu Gln  Phe His Gln 
    1175                 1180                 1185             


Ala Gly  Pro Asn Thr Met Ala  Glu Gln Ser Lys Asn  Trp Leu Pro 
    1190                 1195                 1200             


Gly Pro  Cys Tyr Arg Gln Gln  Arg Leu Ser Lys Asn  Leu Asp Phe 
    1205                 1210                 1215             


Asn Asn  Asn Ser Asn Phe Ala  Trp Thr Ala Ala Thr  Lys Tyr His 
    1220                 1225                 1230             


Leu Asn  Gly Arg Asn Ser Leu  Thr Asn Pro Gly Ile  Pro Met Ala 
    1235                 1240                 1245             


Thr Asn  Lys Asp Asp Glu Asp  Gln Phe Phe Pro Ile  Asn Gly Val 
    1250                 1255                 1260             


Leu Val  Phe Gly Lys Thr Gly  Ala Ala Asn Lys Thr  Thr Leu Glu 
    1265                 1270                 1275             


Asn Val  Leu Met Thr Ser Glu  Glu Glu Ile Lys Thr  Thr Asn Pro 
    1280                 1285                 1290             


Val Ala  Thr Glu Glu Tyr Gly  Val Val Ser Ser Asn  Leu Gln Ser 
    1295                 1300                 1305             


Ser Thr  Ala Gly Pro Gln Ser  Gln Thr Ile Asn Ser  Gln Gly Ala 
    1310                 1315                 1320             


Leu Pro  Gly Met Val Trp Gln  Asn Arg Asp Val Tyr  Leu Gln Gly 
    1325                 1330                 1335             


Pro Ile  Trp Ala Lys Ile Pro  His Thr Asp Gly Asn  Phe His Pro 
    1340                 1345                 1350             


Ser Pro  Leu Met Gly Gly Phe  Gly Leu Lys His Pro  Pro Pro Gln 
    1355                 1360                 1365             


Ile Leu  Ile Lys Asn Thr Pro  Val Pro Ala Asn Pro  Pro Glu Val 
    1370                 1375                 1380             


Phe Thr  Pro Ala Lys Phe Ala  Ser Phe Ile Thr Gln  Tyr Ser Thr 
    1385                 1390                 1395             


Gly Gln  Val Ser Val Glu Ile  Glu Trp Glu Leu Gln  Lys Glu Asn 
    1400                 1405                 1410             


Ser Lys  Arg Trp Asn Pro Glu  Ile Gln Tyr Thr Ser  Asn Tyr Ala 
    1415                 1420                 1425             


Lys Ser  Asn Asn Val Glu Phe  Ala Val Asn Pro Asp  Gly Val Tyr 
    1430                 1435                 1440             


Thr Glu  Pro Arg Pro Ile Gly  Thr Arg Tyr Leu Thr  Arg Asn Leu 
    1445                 1450                 1455             


<210>  430
<211>  3095
<212>  DNA
<213>  Adeno-associated virus

<400>  430
gaattcgccc ttcgcagaga ccaaagttca actgaaacga atcaaccggt ttattgatta       60

acaagcaatt acagattacg ggtgaggtaa cgagtgccaa tggggcgagg ctcagtataa      120

acaccatcag ggttcacagc aaattcaaca ttattagact tggcataatt ggaagtatac      180

tgaatttctg ggttccagcg cttgctgttt tctttctgca gctcccactc gatttccacg      240

ctgacttgtc cggtgctgta ctgcgtgatg aaggaggcaa acttggcagg agtaaacacc      300

tccggaggat tagcaggtac aggtgtgttt ttgatcagga tctgtggagg cgggtgtttg      360

agtccaaaac cgcccatcag aggagacggg tgaaagttgc catccgtgtg aggaattttg      420

gcccagatgg gaccctgcag atacacgtcc cggttctgcc agaccatgcc aggcagtgct      480

ccctggctgt tgatagtctg tgattgaggc ccggctgtag acgactgcag gttgctggag      540

accacaccgt attcttctgt agccacaggg ttagtggtct tgatctcctc ctcgctggtc      600

atcagaacgt tttccagcgt agttttgttg gcagctcccg tcttgccaaa aaccagtacc      660

ccgttgatgg gaaagaactg gtcctcatca tccttgttgg ttgccatggg aatgccagga      720

ttggtcaaag agtttctgcc attcagatga tatttagtgg cagcagtcca ggcaaaattg      780

ctgttgttgt taaagtccaa gttctttgac agtctctgtt gcctatagca gggtccaggc      840

agccagttct ttgactgctc ggccatagta ttgggcccag cttgatgaaa ttgcagttcc      900

ctggtggaac ccgtggtgct ctgggtccgg gccaggtagt acaggtactg gtcgatgaga      960

gggttcatca gccggtctag gctctggctg tgcgcgtagc tgctgtggaa aggcacgtcc     1020

tcgaagctgt aactgaactc aaagttgttg cccgttctca gcatttgaga ggggaaatat     1080

tccaggcagt agaaggagga acggcccacc gattggctgc cgttgtccag agtcaggtag     1140

ccgtactgag gaatcatgaa gacgtccgcc gggaacggag gcaggcagcc ctggtgcgca     1200

gagccgagga cgtacggcag ctggtattcc gagtccgaga agacctgaac cgtgctggta     1260

aggttattag cgatggtcgt gacgccgtca ttcgttgtga cctccttgac ctggatgttg     1320

aggagcttga accgcagctt cttgggccgg aatccccagt tgttgttgat gagtcgctgc     1380

cagtcacgtg gtgagaagtg gcagtggaat ctgttaaagt caaaataccc ccagggggtg     1440

ctgtagccga agtagtggtt gtcattggtg gctcctgagc tgctgctgga gatttgcttg     1500

tagaggtggt tgttgtaggt ggggagggcc caggttctgg tgctggtggt gatgactctg     1560

tcgcccagcc atgtggaatc gcaatgccaa tttcctgagg cattacccac tccgtcggca     1620

ccttcgttat tgtctgccat tggtgcgcca ccgcctgcag ccattgtacc agatcccaca     1680

ctagagggcg ctgctggagg ttctccaaga ggttgagggt cggggactga ctctgagtcg     1740

ccagtctgac caaaattgag cttcttttta gcgggctgct ggcctttttt gccgatgccc     1800

gtggaggagt ctggagagcc tatgggtctc ttctttccag gagccgtctt agcgccttcc     1860

tcaaccagac cgagaggttc gagaacccgc ttcttggcct ggaagactgc tcgcccgagg     1920

ttgcccccaa atgacgtatc ttcttgcaga cgctcctgaa actcggcgtc ggcgtggtta     1980

taccgcaggt acggattgtc acccgctttg agctgctggt cgtaggcctt gtcgtgctcg     2040

agggccgctg cgtccgccgc gttgacgggc tcccccttgt cgagtccgtt gaagggtccg     2100

aggtacttgt agccaggaag caccagaccc cggccgtcgt cctgcttttg ctggttggct     2160

ttgggtttcg gggctccagg tttcaggtcc caccactcgc gaatgccctc agagaggttg     2220

tcctcgagcc aatctggaag ataaccatcg gcagccatac ctggtttaag tcatttattg     2280

ctcagaaaca cagtcgtcca ggtccacgtt gaccaggtcg caggccgagc aagcaatctc     2340

gggtgcccgc cccagcagat gatgaatcgc acacagcttc cgatacgtct tttttctgac     2400

gaccggttga gattctgaca cgccggggaa acattctaaa cagtctctga ccccgtgcgt     2460

gaagcaaatg ttgaaattct gattcattct ctcgcacgtt ttgcagggaa acagcacctg     2520

aagcatgccc gcgtgacgag aacatttgtt ttggtacctg tcggcaaagt ccaccggagc     2580

tccttccgcg tctgacgtcg atgggtccgt gactgaggga cgggcccgct tgggctcgct     2640

tatatccgcg tcatcggggg cgggtctttt gctggctccg ccctttctga cgtagaactc     2700

atgcgtcacc tcagtcacgt gatcactagc ccagcggaag aactctttga cttcctgctt     2760

tgtcaccttg ccaaagtcgt gttccagacg gcgggtgagt tcaaatttga acatccggtc     2820

ctgcaacggt tgctggtgct cgaaggtggt gctgttcccg tcgatcacgg cgcacatgtt     2880

ggtgttggag gtgacgatca cgggggtggg atcgatctgg gcggacgact tgcacttttg     2940

gtccacgcgc accttgctgc cgccgagaat ggccttggcg gactccacga ccttggccgt     3000

catcttgccc tcctcccacc agatcaccat cttgtcgacg caatcgttga agggaaagtt     3060

ctcattggtc cagttgacgc agcaagggcg aattc                                3095


<210>  431
<211>  3095
<212>  DNA
<213>  Adeno-associated virus

<400>  431
gaattcgccc ttcgcagaga ccaaagttca actgaaacga atcaaccggt ttattgatta       60

acaagcaatt acagattacg ggtgaggtaa cgagtgccaa tggggcgagg ctcagtataa      120

acaccatcag ggttcacagc aaattcaaca ttattagact tggcataatt ggaagtatac      180

tgaatttctg ggttccagcg cttgctgttt tctttctgca gctcccactc gatttccacg      240

ctgacttgtc cggtgctgta ctgcgtgatg aaggaggcaa acttggcagg agtaaacacc      300

tccggaggat tagcaggtac aggtgtgttt ttgatcagga tctgtggagg cgggtgttcg      360

agtccaaaac cgcccatcag aggagacggg tgaaagttgc catccgtgtg aggaattttg      420

gcccagatgg gaccctgcag atacacgtcc cggttctgcc agaccatgcc aggcagtgct      480

ccctggctgt tgatagtctg tgattgaggc ccggctgtag acgactgcag gttgctggag      540

accacaccgt attcttctgt agccacaggg ttagtggtct tgatctcctc ctcgctggtc      600

atcagaacgt tttccagcgt agttttgttg gcagctcccg tcttgccaaa aaccagtacc      660

ccgttgatgg gaaagaactg gtcctcatca tccttgttgg ttgccatggg aatgccagga      720

ttggtcaaag agtttctgcc attcagatga tatttagtgg cagcagtcca ggcaaaattg      780

ctgttgttgt taaagtccaa gttctttgac agtctctgtt gcctatagca gggtccaggc      840

agccagttct ttgactgctc ggccatagta ttgggcccag cttgatgaaa ttgcagttcc      900

ctggtggaac ccgtggtgct ctgggtccgg gccaggtagt acaggtactg gtcgatgaga      960

gggttcatca gccggtctag gctctggctg tgcgcgtagc tgctgtggaa aggcacgtcc     1020

tcgaagctgt aactgaactc aaagttgttg cccgttctca gcatttgaga ggggaaatat     1080

tccaggcagt agaaggagga acggcccacc gattggctgc cgttgttcag agtcaggtag     1140

ccgtactgag gaatcatgaa gacgtccgcc gggaacggag gcaggcagcc ctggtgcgca     1200

gagccgagga cgtacggcag ctggtattcc gagtccgaga agacctgaac cgtgctggta     1260

aggttattag cgatggtcgt gacgccgtca ttcgttgtga cctccttgac ctggatgttg     1320

aagagcttga accgcagctt cttgggccgg aatccccagt tgttgttgat gagtcgctgc     1380

cagtcacgtg gtgagaagtg gcagtggaat ctgttaaagt caaaataccc ccagggggtg     1440

ctgtagccga agtagtggtt gtcattggtg gctcctgagc tgctgctgga gatttgcttg     1500

tagaggtggt tgttgtaggt ggggagggcc caggttctgg tgctggtggt gatgactctg     1560

tcgcccagcc atgtggaatc gcaatgccaa tttcctgagg cattacccac tccgtcggca     1620

ccttcgttat tgtctgccgt tggtgcgcca ccgcctgcag ccattgtacc agatcccaca     1680

ctagagggcg ctgctggagg ttctccaaga ggttgagggt cggggactga ctctgagtcg     1740

ccagtctgac caaaattgag cttcttttta gcgggctgct ggcctttttt gccgatgccc     1800

gtggaggagt ctggagagtc tatgggtctc ttctttccag gagccgtctt agcgccttcc     1860

tcaaccagac cgagaggttc gagaacccgc ttcttggcct ggaagactgc tcgcccgagg     1920

ttgcccccaa atgacgtatc ttcttgcagg cgctcctgaa actcggcgtc ggcgtggtta     1980

taccgcaggt acggattgtc acccgctttg agctgctggt cgtaggcctt gtcgtgctcg     2040

agggccgctg cgtccgccgc gttgacgggc tcccccttgt cgagtccgtt gaagggtccg     2100

aggtacttgt agccaggaag caccagaccc cggccgtcgt cctgcttttg ctggttggct     2160

ttgggtttcg gggctccagg tttcaggtcc caccactcgc gaatgccctc agagaggttg     2220

tcctcgagcc aatctggaag ataaccatcg gcagccatac ctggtttaag ccatttattg     2280

ctcagaaaca cagtcgtcca ggtccacgtt gaccaggtcg caggccgagc aggcaatctc     2340

gggtgcccgc cccagcagat gatgaatcgc acacagcttc cgatacgtct tttttctgac     2400

gaccggttga gattctgaca cgccggggaa acattctaaa cagtctctga ccccgtgcgt     2460

gaagcaaatg ttgaaattct gattcattct ctcgcacgtt ttgcagggaa acagcatctg     2520

aagcatgccc gcgtggcgag aacatttgtt ttggtacctg tcggcaaagt ccaccggagc     2580

tccttccgcg tctgacgtcg atgggtccgt gactgaggga caggcccgct tgggctcgct     2640

tatatccgcg tcatcggggg cgggtctttt gctggctccg ccctttctga cgtagaactc     2700

atgcgtcacc tcagtcacgt gatcactagc ccagcggaag aactctttga cttcctgctt     2760

tgtcaccttg ccaaagtcgt gttccagacg gcgggtgagt tcaaatttga acatccggtc     2820

ctgcaacggc tgctggtgct cgaaggtggt gctgttcccg tcgatcacgg cgcgcatgtt     2880

ggtgttggag gtgacgatca cgggggtggg atcgatctgg gcggacgact tgcacttttg     2940

gtccacgcgc accttgctgc cgccgagaat ggccttggcg gactccacga ccttggccgt     3000

catcttgccc tcctcccacc agatcaccat cttgtcgacg caatcgttga agggaaagtt     3060

ctcattggtc cagttgacgc agcaagggcg aattc                                3095


<210>  432
<211>  729
<212>  PRT
<213>  Adeno-associated virus

<400>  432

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Asp Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Thr Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Ser Ser Ser Gly Ala Thr Asn Asp Asn His Tyr Phe Gly Tyr 
            260                 265                 270         


Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe 
        275                 280                 285             


Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg 
    290                 295                 300                 


Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val 
305                 310                 315                 320 


Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser Phe Glu Asp Val Pro 
                405                 410                 415     


Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn 
            420                 425                 430         


Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr 
        435                 440                 445             


Thr Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr 
    450                 455                 460                 


Met Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln 
465                 470                 475                 480 


Gln Arg Leu Ser Lys Asn Leu Asp Phe Asn Asn Asn Ser Asn Phe Ala 
                485                 490                 495     


Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr 
            500                 505                 510         


Asn Pro Gly Ile Pro Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe 
        515                 520                 525             


Phe Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn 
    530                 535                 540                 


Lys Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys 
545                 550                 555                 560 


Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn 
                565                 570                 575     


Leu Gln Ser Ser Thr Ala Gly Pro Gln Ser Gln Thr Ile Asn Ser Gln 
            580                 585                 590         


Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln 
        595                 600                 605             


Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro 
    610                 615                 620                 


Ser Pro Leu Met Gly Gly Phe Gly Leu Glu His Pro Pro Pro Gln Ile 
625                 630                 635                 640 


Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr 
                645                 650                 655     


Pro Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
            660                 665                 670         


Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp 
        675                 680                 685             


Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val 
    690                 695                 700                 


Glu Phe Ala Val Asn Pro Asp Gly Val Tyr Thr Glu Pro Arg Pro Ile 
705                 710                 715                 720 


Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 


<210>  433
<211>  729
<212>  PRT
<213>  Adeno-associated virus

<400>  433

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Asp Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Thr Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Ser Ser Ser Gly Ala Thr Asn Asp Asn His Tyr Phe Gly Tyr 
            260                 265                 270         


Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe 
        275                 280                 285             


Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg 
    290                 295                 300                 


Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val 
305                 310                 315                 320 


Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser Phe Glu Asp Val Pro 
                405                 410                 415     


Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn 
            420                 425                 430         


Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr 
        435                 440                 445             


Thr Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr 
    450                 455                 460                 


Met Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln 
465                 470                 475                 480 


Gln Arg Leu Ser Lys Asn Leu Asp Phe Asn Asn Asn Ser Asn Phe Ala 
                485                 490                 495     


Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr 
            500                 505                 510         


Asn Pro Gly Ile Pro Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe 
        515                 520                 525             


Phe Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn 
    530                 535                 540                 


Lys Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys 
545                 550                 555                 560 


Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn 
                565                 570                 575     


Leu Gln Ser Ser Thr Ala Gly Pro Gln Ser Gln Thr Ile Asn Ser Gln 
            580                 585                 590         


Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln 
        595                 600                 605             


Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro 
    610                 615                 620                 


Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile 
625                 630                 635                 640 


Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr 
                645                 650                 655     


Pro Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
            660                 665                 670         


Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp 
        675                 680                 685             


Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val 
    690                 695                 700                 


Glu Phe Ala Val Asn Pro Asp Gly Val Tyr Thr Glu Pro Arg Pro Ile 
705                 710                 715                 720 


Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 


<210>  434
<211>  729
<212>  PRT
<213>  Adeno-associated virus

<400>  434

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Asp Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Ser Ser Ser Gly Ala Thr Asn Asp Asn His Tyr Phe Gly Tyr 
            260                 265                 270         


Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe 
        275                 280                 285             


Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg 
    290                 295                 300                 


Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val 
305                 310                 315                 320 


Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser Phe Glu Asp Val Pro 
                405                 410                 415     


Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn 
            420                 425                 430         


Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr 
        435                 440                 445             


Thr Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr 
    450                 455                 460                 


Met Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln 
465                 470                 475                 480 


Gln Arg Leu Ser Lys Asn Leu Asp Phe Asn Asn Asn Ser Asn Phe Ala 
                485                 490                 495     


Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr 
            500                 505                 510         


Asn Pro Gly Ile Pro Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe 
        515                 520                 525             


Phe Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn 
    530                 535                 540                 


Lys Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys 
545                 550                 555                 560 


Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn 
                565                 570                 575     


Leu Gln Ser Ser Thr Ala Gly Pro Gln Ser Gln Thr Ile Asn Ser Gln 
            580                 585                 590         


Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln 
        595                 600                 605             


Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro 
    610                 615                 620                 


Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile 
625                 630                 635                 640 


Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr 
                645                 650                 655     


Pro Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
            660                 665                 670         


Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp 
        675                 680                 685             


Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val 
    690                 695                 700                 


Glu Phe Ala Val Asn Pro Asp Gly Val Tyr Thr Glu Pro Arg Pro Ile 
705                 710                 715                 720 


Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 


<210>  435
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  435
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tacaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcggcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gcccttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattttgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgcacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccgtcgagt     1620

ggagtcctga tgtttggaaa acagggtgct ggaagagaca atgtggacta cagcagcgtt     1680

atgctaacca gcgaagaaga aattaaaacc actaaccctg tagccacaga acaatacggt     1740

gtggtggctg acaacttgca gcaaaccaat acagggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccaccctt caccgctaat gggaggattt     1920

ggactgaagc acccacctcc tcagatcctg atcaagaaca cgccggtacc tgcggatcct     1980

ccaacaacgt tcagccaggc gaaattggct tccttcatta cgcagtacag caccggacag     2040

gtcagcgtgg aaatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaacccagag     2100

attcagtaca cttcaaacta ctacaaatct acaaatgtgg actttgctgt caatacagag     2160

ggaacttatt ctgagcctcg ccccattggt actcgctacc tcacccgtaa tctgtaa        2217


<210>  436
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  436

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Arg Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Pro Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu His Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  437
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  437
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattttgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccgtcgagt     1620

ggagtcctga tgtttggaaa acagggtgct ggaagagaca atgtggacta cagcagcgtt     1680

atgctaacca gcgaagaaga aattaaaacc actaaccctg tagccacaga acaatacggt     1740

gtggtggctg ataacttgca gcaaaccaat acggggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccaccctt caccgctaat gggaggattt     1920

ggactgaagc acccacctcc tcagatcctg atcaagaaca cgccggtacc tgcggatcct     1980

ccaacaacgt tcagccaggc gaaattggct tccttcatta cgcagtacag caccggacag     2040

gtcagcgtgg aaatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaacccagag     2100

attcagtaca cttcaaacta ctacaaatct acaaatgtgg actttgctgt caatacagag     2160

ggaacttatt ctgagcctcg ccccattggt actcgttacc tcacccgtaa tctgtaa        2217


<210>  438
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  438

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  439
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  439

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asp Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Arg Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Ala Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Ser Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  440
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  440
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcaggatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattttgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcgggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg ttgctatggc aacgcataag gacgacgagg aacgtttctt tccatcgagc     1620

ggagtcctga tgtttggaaa acagggtgct ggaagagaca atgtggacta tagcagcgtt     1680

atgctaacca gcgaggaaga aattaaaacc actaaccctg tagccacaga acaatacggt     1740

gtggtggctg acaacttgca gcaagccaat acagggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaaa ttcctcacac ggacggcaat tttcacccgt ctcctctgat gggcggcttt     1920

ggactgaagc acccacctcc ccagatcctg atcaagaata cgccggtacc tgcggatcct     1980

ccaacgacgt tcagccaggc aaaattggct tccttcatca cgcagtacag caccggccag     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgatg gaacccagaa     2100

attcagtaca cttccaacta ctacaaatct acaaatgtgg actttgctgt caattctgag     2160

ggtacatatt cagagcctcg ccccattggt actcgttatc tgacacgtaa tctgtaa        2217


<210>  441
<211>  2211
<212>  DNA
<213>  Adeno-associated virus

<400>  441
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gcctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctcg aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccagtaga gcagtcaccc caagaaccag actcctcctc gggcatcggc      480

aagaaaggcc aacagcccgc cagaaaaaga ctcaattttg gccagactgg cgactcagag      540

tcagttccag accctcaacc tctcggagaa cctccagcag cgccctctgg tgtgggacct      600

aatacaatgg ctgcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tccaacggga catcgggagg agccaccaac gacaacacct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagagactca gcttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcccac     1080

cagggctgcc tgcctccgtt cccggcggac gtgttcatga ttccccagta cggctaccta     1140

acactcaaca acggtagtca ggccgtggga cgctcctcct tctactgcct ggaatacttt     1200

ccttcgcaga tgctgagaac cggcaacaac ttccagttta cttacacctt cgaggacgtg     1260

cctttccaca gcagctacgc ccacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacggc aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca acaacgcgtc tcaacgacaa ccgggcaaaa caacaatagc     1500

aactttgcct ggactgctgg gaccaaatac catctgaatg gaagaaattc attggctaat     1560

cctggcatcg ctatggcaac acacaaagac gacgaggagc gttttttccc agtaacggga     1620

tcctgttttt ggcaacaaaa tgctgccaga gacaatgcgg attacagcga tgtcatgctc     1680

accagcgagg aagaaatcaa aaccactaac cctgtggcta cagaggaata cggtatcgtg     1740

gcagataact tgcagcagca aaacacggct cctcaaattg gaactgtcaa cagccagggg     1800

gccttacccg gtatggtctg gcagaaccgg gacgtgtacc tgcagggtcc catctgggcc     1860

aagattcctc acacggacgg caacttccac ccgtctccgc tgatgggcgg ctttggcctg     1920

aaacatcctc cgcctcagat cctgatcaag aacacgcctg tacctgcgga tcctccgacc     1980

accttcaacc agtcaaagct gaactctttc atcacgcaat acagcaccgg acaggtcagc     2040

gtggaaattg aatgggagct acagaaggaa aacagcaagc gctggaaccc cgagatccag     2100

tacacctcca actactacaa atctacaagt gtggactttg ctgttaatac agaaggcgtg     2160

tactctgaac cccgccccat tggcacccgt tacctcaccc gtaatctgta a              2211


<210>  442
<211>  736
<212>  PRT
<213>  Adeno-associated virus

<400>  442

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr His 
        515                 520                 525             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Val Thr Gly Ser Cys Phe Trp 
    530                 535                 540                 


Gln Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met Leu 
545                 550                 555                 560 


Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro Gln 
            580                 585                 590         


Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  443
<211>  2214
<212>  DNA
<213>  Adeno-associated virus

<400>  443
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcagcgc ggcggacgca gcggccctcg agcacgacaa ggcctgcgac      240

cagcggctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaagg gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggctg acaataacga gggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggctttg cccacctaca acaatcacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcgg      900

ctcatcaaca acaactgggg attccggccc aagaagctca acttcaagct gttcaacatc      960

caggtcaagg aggtcacaac gaatgacggc gtcacgacca tcgccaataa ccttaccagc     1020

acggttcagg tcttttcgga ctcggaatac cagctgccct acgtcctcgg ctccgcacac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttccccagta cggctacctg     1140

actctgaaca atggcagcca atcggtgggt cgttcctctt tctactgcct ggaatatttc     1200

ccttctcaaa tgctgagaac gggcaacaac ttcaccttca gctacacctt cgaggacgtt     1260

cccttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcctcttatc     1320

gaccagtacc tgtattacct ggccagaaca cagagcaacg caggaggcac agctggcaat     1380

cgggaactgc agttttatca gggcgggcct accaccatgg ccgaacaagc caaaaactgg     1440

ctgcctggac cttgcttccg gcaacaaaga gtctccaaga cgctggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa taccatctaa atggaagaaa ttcattggtt     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccttcgagc     1620

ggagtcctga tttttggaaa aactggagca gctaataaga ctacactgga aaatgtgtta     1680

atgacaaatg aagaggaaat tcgtcctacc aacccggtag ccaccgagga atacgggact     1740

gttagcagca acctgcaggc ggctaacact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttt cacccgtctc cgctgatggg cggctttgga     1920

ctgaagcatc cgcctcctca gatcctgatc aaaaacactc ctgttcctgc taatcccccg     1980

gaggtgttta cgcctgccaa gtttgcttct ttcatcacac agtacagcac cggccaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gagaacagca agcgctggaa cccagagatt     2100

cagtatacct ccaattttga cgaacagact ggtgtggact ttgccgttga cagccagggt     2160

gtttattctg agcctcgccc cattggtact cgttacctca cccgtaatct gtaa           2214


<210>  444
<211>  737
<212>  PRT
<213>  Adeno-associated virus

<400>  444

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Ser Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Cys Asp 
65                  70                  75                  80  


Gln Arg Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Gly 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Glu Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  445
<211>  2214
<212>  DNA
<213>  Adeno-associated virus

<400>  445
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggctttg cccacctaca acaaccacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcgg      900

ctcatcaaca acaactgggg attccggccc aagaagctca acttcaagct gttcaacatc      960

caggtcaagg aggtcacaac gaatgacggc gtcacgacca tcgccaataa ccttaccagc     1020

acggttcagg tcttttcgga ctcggaatac cagctgccct acgtcctcgg ctccgcacac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttcctcagta cggctacctg     1140

actctcaaca acggtagtca ggccgtggga cgttcctcct tctactgcct ggagtacttc     1200

ccctctcaga tgctgagaac gggcaacaac ttttccttca gctacacttt cgaggacgtg     1260

cctttccaca gcagctacgc gcacagccag agtttggaca ggctgatgaa tcctctcatc     1320

gaccagtacc tgtactacct gtcaagaacc cagtctacgg gaggcacagc gggaacccag     1380

cagttgctgt tttctcaggc cgggcctagc aacatgtcga ctcaggccag aaactggctg     1440

cctggaccct gctacagaca gcagcgcgtc tccacgacac tgtcgcaaaa caacaacagc     1500

aactttgcct ggactggtgc caccaagtat catctgaacg gcagagactc tctggtgaat     1560

ccgggcgtcg ccatggcaac caacaaggac gacgaggacc gcttcttccc atccagcggc     1620

atcctcatgt ttggcaagca gggagctgga aaagacaacg tggactatag caacgtgatg     1680

ctaaccagcg aggaagaaat caagaccacc aaccccgtgg ccacagaaca gtatggcgtg     1740

gtggctgata acctacagca gcaaaacacc gctcctattg tgggggccgt caacagccag     1800

ggagccttac ctggcatggt ctggcagaac cgggacgtgt acctgcaggg tcctatttgg     1860

gccaagattc ctcacacaga tggcaacttt cacccgtctc ctttaatggg cggctttgga     1920

cttaaacatc cgcctcctca gatccttatc aaaaacactc ctgttcctgc ggatcctcca     1980

acagcgttca accaggccaa gctgaattct ttcatcacgc agtacagcac cggacaagtc     2040

agcgtggaga tcgagtggga gctgcagaag gagaacagca agcgctggaa cccagagatt     2100

cagtatactt ccaactacta caaatctaca aatgtggact ttgctgttaa tactgagggt     2160

gcttactctg agcctcgccc cattggcact cgttacctca cccgtaatct gtaa           2214


<210>  446
<211>  737
<212>  PRT
<213>  Adeno-associated virus

<400>  446

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu Phe 
    450                 455                 460                 


Ser Gln Ala Gly Pro Ser Asn Met Ser Thr Gln Ala Arg Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser Gln 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr Asn 
        515                 520                 525             


Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met Phe 
    530                 535                 540                 


Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val Met 
545                 550                 555                 560 


Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro 
            580                 585                 590         


Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Ala Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  447
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  447
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaaggcc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210>  448
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  448

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  449
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  449
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagcacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgctga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacggttc aggtcttttc ggactcggaa taccagctgc cctacgtcct cggctccgca     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

ctgactctga acaatggcag ccaatcggtg ggtcgttcct ctttctactg cctggaatat     1200

ttcccttctc aaatgctgag aacgggcaac aacttcacct tcagctacac cttcgaggac     1260

gttcccttcc acagcagcta cgcacacagc cagagcctgg accggctgat gaatcctctt     1320

atcgaccagt acctgtatta cctggccaga acacagagca acgcaggagg cacagctggc     1380

aatcgggaac tgcagtttta tcagggcggg cctaccacca tggccgaaca agccaaaaac     1440

tggctgcctg gaccttgctt ccggcaacaa agagtctcca agacgctgga tcaaaacaac     1500

aacagcaact ttgcttggac tggtgccacc aaataccatc taaatggaag aaattcattg     1560

gttaatcccg gtgtcgccat ggcaacccac aaggacgacg aggaacgctt cttcccttcg     1620

agcggagtcc tgatttttgg aaaaactgga gcagctaata agactacact ggaaaatgtg     1680

ttaatgacaa atgaagagga aattcgtcct accaacccgg tagccaccga ggaatacggg     1740

actgttagca gcaacctgca ggcggctaac actgcagccc agacacaagt tgtcaacaac     1800

cagggagcct tacctggtat ggtctggcag aaccgggacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac tttcacccgt ctccgctgat gggcggcttt     1920

ggactgaagc atccgcctcc tcagatcctg atcaaaaaca ctcctgttcc tgctaatccc     1980

ccggaggtgt ttacgcctgc caagtttgct tctttcatca cacagtacag caccggccag     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cctccaattt tgacaaacag actggtgtgg actttgccgt tgacagccag     2160

ggtgtttatt ctgagcctcg ccccattggt actcgttacc tcacccgtaa tctgtaa        2217


<210>  450
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  450

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys His Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ala Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu 
    450                 455                 460                 


Gln Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn 
465                 470                 475                 480 


Trp Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu 
                485                 490                 495     


Asp Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr 
            500                 505                 510         


His Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala 
        515                 520                 525             


Thr His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu 
    530                 535                 540                 


Ile Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val 
545                 550                 555                 560 


Leu Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala 
            580                 585                 590         


Ala Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  451
<211>  737
<212>  PRT
<213>  Adeno-associated virus

<400>  451

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Lys Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Ser 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  452
<211>  737
<212>  PRT
<213>  Adeno-associated virus

<400>  452

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Ser 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  453
<211>  737
<212>  PRT
<213>  Adeno-associated virus

<400>  453

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  454
<211>  737
<212>  PRT
<213>  Adeno-associated virus

<400>  454

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Lys Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  455
<211>  2214
<212>  DNA
<213>  Adeno-associated virus

<400>  455
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggctg acaataacaa gggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggctttg cccacctaca acaaccacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcgg      900

ctcatcaaca gcaactgggg attccggccc aagaagctca acttcaagct gttcaacatc      960

caggtcaagg aggtcacaac gaatgacggc gtcacgacca tcgccaataa ccttaccagc     1020

acggttcagg tcttttcgga ctcggaatac cagctgccct acgtcctcgg ctccgcacac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttccccagta cggctacctg     1140

actctgaaca atggcagcca atcggtgggt cgttcctctt tctactgcct ggaatatttc     1200

ccttctcaaa tgctgagaac gggcaacaac ttcaccttca gctacacctt cgaggacgtt     1260

cccttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcctcttatc     1320

gaccagtacc tgtattacct ggccagaaca cagagcaacg caggaggcac agctggcaat     1380

cgggaactgc agttttatca gggcgggcct accaccatgg ccgaacaagc caaaaactgg     1440

ctgcctggac cttgcttccg gcaacaaaga gtctccaaga cgctggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa taccatctaa atggaagaaa ttcattggtt     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccttcgagc     1620

ggagtcctga tttttggaaa aactggagca gctaataaga ctacactgga aaatgtgtta     1680

atgacaaatg aagaggaaat tcgtcctacc aacccggtag ccaccgagga atacgggact     1740

gttagcagca acctgcaggc ggctaacact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttt cacccgtctc cgctgatggg cggctttgga     1920

ctgaagcatc cgcctcctca gatcctgatc aaaaacactc ctgttcctgc taatcccccg     1980

gaggtgttta cgcctgccaa gtttgcttct ttcatcacac agtacagcac cggccaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gagaacagca agcgctggaa cccagagatt     2100

cagtatacct ccaattttga caaacagact ggtgtggact ttgccgttga cagccagggt     2160

gtttattctg agcctcgccc cattggtact cgttacctca cccgtaatct gtaa           2214


<210>  456
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  456
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgcac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acttatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggag taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggcaac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acatgggcta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacgg caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210>  457
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  457

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro His Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Leu Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Asn Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Met Gly Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Gly Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  458
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  458
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccggaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

gtcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gagcccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210>  459
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  459

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Gly Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Val Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Ser Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  460
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  460
atggttgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcagggc      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctta aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagctt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgcg ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gccagcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagccgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210>  461
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  461

Met Val Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Gly Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Leu Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Gln Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Pro Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  462
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  462
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa tagcctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactccca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgtcttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacttgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210>  463
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  463

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Ser Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Pro Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Ser Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  464
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  464

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Val His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Ser Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Pro Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  465
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  465
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgtgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aattcgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc ccacccgtaa tctgtaa        2217


<210>  466
<211>  734
<212>  PRT
<213>  Adeno-associated virus

<400>  466

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Arg Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Thr Ala Ser Gly Thr Gln Gln Ser Arg Leu Leu Phe Ser Gln Ala 
    450                 455                 460                 


Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly Pro 
465                 470                 475                 480 


Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn Asn 
                485                 490                 495     


Ser Asn Phe Pro Trp Thr Gly Ala Thr Lys Tyr Tyr Leu Asn Gly Arg 
            500                 505                 510         


Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp Asp 
        515                 520                 525             


Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys Glu 
    530                 535                 540                 


Gly Thr Asn Ala Thr Asn Ala Glu Leu Glu Asn Val Met Ile Thr Asp 
545                 550                 555                 560 


Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly 
                565                 570                 575     


Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Ala Ala Ser Thr Glu 
            580                 585                 590         


Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp Arg 
        595                 600                 605             


Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu 
        675                 680                 685             


Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn 
    690                 695                 700                 


Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr Ser 
705                 710                 715                 720 


Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 


<210>  467
<211>  2214
<212>  DNA
<213>  Adeno-associated virus

<400>  467
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca acctctcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggctttg cccacctaca acaaccacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagaagctca acttcaagct cttcaacatc      960

caagtcaagg aggtcacgac gaatgacggc gtcacgacca tcgctaataa ccttaccagc     1020

acggttcagg tcttttcgga ctcggagtac cagctgccgt acgtcctcgg ctctgcccac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttcctcagta cggctacctg     1140

actctgaaca atggcagcca atcggtggga cgttcatcct tctactgcct ggaatacttc     1200

ccttctcagg tgctgagaac gggtaacaac ttcaccttca gttacacctt cgaggacgtg     1260

cctttccaca gcagctacgc gcacagccag agcctagacc ggctgatgaa tcccctcatc     1320

gaccagtacc tgtattacct ggctagaaca cagagtaacc caggaggcac atctggcaat     1380

cgggaactgc agttttacca gggcgggcct tccaccatgg ccgaacaagc caagaactgg     1440

ttacctggac cttgcttccg gcaacaaaga gtttccaaaa cactggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggcagaaa ctcattggtg     1560

aatcctggtg tcgccatggc aactcacaag gacgacgagg accgcttttt cccatccagc     1620

ggagtcctga tttttggaaa aactggagca accaacaaga ctacattgga aaacgtgtta     1680

atgacaaatg aagaagaaat tcgtcctact aatcctgtgg ccacagaaga atacgggata     1740

gtcagcagca atttacaagc ggccaatact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggcatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaaaattc ctcacacaga cggcaacttt cacccgtctc cgctgatggg cggctttgga     1920

ctgaagcatc cgcctcctca gatcctgatc aaaaacactc ctgttcctgc taatcccccg     1980

gaggtgttta cgcctgccaa gtttgcttct ttcatcacac agtacagcac cggccaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gagaacagca agcgctggaa cccagagatt     2100

cagtatacct ccaattttga caaacagact ggtgtggact ttgccgttga cagccagggt     2160

gtttattctg agcctcgccc cattggtact cgttacctca cccgtaatct gtaa           2214


<210>  468
<211>  737
<212>  PRT
<213>  Adeno-associated virus

<400>  468

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Val Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Pro Gly Gly Thr Ser Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Ser Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Thr Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  469
<211>  2214
<212>  DNA
<213>  Adeno-associated virus

<400>  469
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca cacggctggg cgacagagtc      720

atcaccacca gcacccggac ctgggctttg cccacctaca acaaccacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcgg      900

ctcatcaaca acaactgggg attccggccc aagaagctca acttcaagct gttcaacatc      960

caggtcaagg aggtcacaac gaatgacggc gtcacgacca tcgccaataa ccttaccagc     1020

acggttcagg tcttttcgga ctcggaatac cagctgccct acgtcctcgg ctccgcacac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttccccagta cggctacctg     1140

actctgaaca atggcagcca atcggtgggt cgttcctctt tctactgcct ggaatatttc     1200

ccttctcaaa tgctgagaac gggcaacaac ttcaccttca gctacacctt cgaggacgtt     1260

cccttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcctcttatc     1320

gaccagtacc tgtattacct ggccagaaca cagagcaacg caggaggcac agctggcaat     1380

cgggaactgc agttttatca gggcgggcct accaccatgg ccgaacaagc caaaaactgg     1440

ctgcctggac cttgcttccg gcaacgaaga gtctccaaga cgctggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa taccatctaa atggaagaaa ttcattggtt     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccttcgagc     1620

ggagtcctga tttttggaaa aactggagca gctaataaga ctacactgga aaatgtgtta     1680

atgacaaatg aagaggaaat tcgtcctacc aacccggtag ccaccgagga atacgggact     1740

gttagcagca acctgcaggc ggctaacact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttt cacccgtctc cgctgatggg cggctttgga     1920

ctgaagcatc cgcctcctca gatcctgatc aaaaacactc ctgttcctgc taatcccccg     1980

gaggtgttta cgcctgccaa gtttgcttct ttcatcacac agtacagcac cggccaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gagaacagca agcgctggaa cccagagatt     2100

cagtatacct ccaattttga caaacagact ggtgtggact ttgccgttga cagccagggt     2160

gtttattctg agcctcgccc cattggtact cgttacctca cccgtaatct gtaa           2214


<210>  470
<211>  737
<212>  PRT
<213>  Adeno-associated virus

<400>  470

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Arg Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Arg Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  471
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  471
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tttgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cttcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggcccagccc acctacaaca accacctcta caagcaaatc      780

tcaagccaat caggagcctc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcgggtcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gtactggaaa caactttcag ttcagctaca cctttgaaga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa aacacaatca aatagtggag ctcttcagca gtctcggcta     1380

ctgtttagtc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctacctgga     1440

ccttgctaca gacagcagcg tctgtcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtaccaccta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagtcacaa agacgatgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggacaatgt catgattaca     1680

gatgaagaag aaatccgcac caccaatccc gtggctacgg agcagtacgg atatgtgtca     1740

aataatttgc aaaactcaaa tactggtcca actactggaa ctgtcaatca ccgaggagcg     1800

ttacctggca tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactga tgggaggttt tgggctcaaa     1920

cacccgcctc ctcagatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaagagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  472
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  472

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Gln Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Ala Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Asp Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Arg Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  473
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  473
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgcg ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

acctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgcgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210>  474
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  474

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Thr Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Ala Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  475
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  475
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggccgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagctgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaagca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagtgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210>  476
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  476

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Ser Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Cys Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  477
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  477

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Ser Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  478
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  478
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggctg acaataacga gggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggctttg cccacctaca acaaccacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcgg      900

ctcatcaaca acaactgggg attccggccc aagaagctca acttcaagct gttcaacatc      960

caggtcaagg aggtcacaac gaatgacggc gtcacgacca tcgccaataa ccctaccagc     1020

acggttcagg tcttttcgga ctcggaatac cagctgccct acgtcctcgg ctccgcacac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttccccagta cggctacctg     1140

actctgaaca atggcagcca atcggtgggt cgttcctctt tctactgcct ggaatatttc     1200

ccttctcaaa tgctgagaac gggcaacaac ttcaccttca gctacacctt cgaggacgtt     1260

cccttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcctcttatc     1320

gaccagtacc tgtattacct ggccagaaca cagagcaacg caggaggcac agctggcaat     1380

cgggaactgc agttttatca gggcgggcct accaccatgg ccgaacaagc caaaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210>  479
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  479

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Pro Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  480
<211>  2208
<212>  DNA
<213>  Adeno-associated virus

<400>  480
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcac       60

gagtggtggg acccgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacccaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaacg tctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgtcact tctcaccacg tgaccggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cggaaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccttcgagc     1620

ggagtcctga tttttggaaa aactggagca gctaataaga ctacactgga aaatgtgtta     1680

atgacaaatg aagaggaaat tcgtcctacc aacccggtag ccaccgagga atacgggact     1740

gttagcagca acctgcaggc ggctaacact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttt cacccgtctc cgctgatggg cggctttgga     1920

ctgaagcatc ctcagatcct gatcaaaaac actcctgttc ctgctaatcc cccggaggtg     1980

tttacgcctg ccaagtttgc ttctttcatc acacagtaca gcaccggcca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaagcgct ggaacccaga gattcagtat     2100

acctccaatt ttgacaaaca gactggtgtg gactttgccg ttgacagcca gggtgtttat     2160

tctgagcctc gccccattgg tactcgttac ctcacccgta atctgtaa                  2208


<210>  481
<211>  735
<212>  PRT
<213>  Adeno-associated virus

<400>  481

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile His Glu Trp Trp Asp Pro Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr His Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Arg Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Glu Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Phe 
    690                 695                 700                 


Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  482
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  482

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Pro Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Pro Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asp Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Val Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  483
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  483
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaagg ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgacccatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctaccc tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaagac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcaggtcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210>  484
<211>  2214
<212>  DNA
<213>  Adeno-associated virus

<400>  484
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttc      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggctgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gagccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggctg acaataacaa gggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggctttg cccacctaca acaaccacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcgg      900

ctcatcaaca acaactgggg attccggccc aagaagctca acttcaagct gttcaacatc      960

caggtcaagg aggtcacaac gggtgacggc gtcacgacca tcgccaataa ccttaccagc     1020

acggttcagg tcttttcgga ctcggaatac cagctgccct acgtcctcgg ctccgcacac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttccccagta cggctacctg     1140

actctgaaca atgacagcca atcggtgggt cgttcctctt tctactgcct ggaatatttc     1200

ccttctcaaa tgctgagaac gggcaacaac ttcaccttca gctacacctt cgaggacgtt     1260

cccttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcctcttatc     1320

gaccagtacc tgtattacct ggccagaaca cagagcaacg caggaggcac agctggcaat     1380

cgggaactgc agttttatca gggcgggcct accaccatgg ccgaacaagc caaaaactgg     1440

ctgcctggac cttgcttccg gcaacaaaga gtctccaaga cgctggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa taccatctaa atggaagaaa ttcattggtt     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccttcgagc     1620

ggagtcctga tttttggaaa aactggagca gctaataaga ctacactgga aaatgtgtta     1680

atgacaaatg aagaggaaat tcgtcctacc aacccggtag ccaccgagga atacgggact     1740

gttagcagca acctgcaggc ggctaacact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttt cacccgtctc cgctgatggg cggctttgga     1920

ctgaagcatc cgcctcctca gatcctgatc aaaaacactc ctgttcctgc taatcccccg     1980

gaggtgttta cgcctgccaa gtttgcttct ttcatcacac agtacagcac cggccaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gagaacagca agcgctggaa cccagagatt     2100

cagtatacct ccaattttga caaacagact ggtgtggact ttgccgttga cagccagggt     2160

gtttattctg agcctcgccc cattggtact cgttacctca cccgtaatct gtaa           2214


<210>  485
<211>  737
<212>  PRT
<213>  Adeno-associated virus

<400>  485

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Ala Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Lys Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Gly Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Asp Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  486
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  486
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgtgtg ggagctgcag aaggagaaca gcaagcgcag gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210>  487
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  487

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Val Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Arg Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  488
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  488

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  489
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  489

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Val Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  490
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  490

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  491
<211>  2214
<212>  DNA
<213>  Adeno-associated virus

<400>  491
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggctttg cccacctaca acaaccacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcgg      900

ctcatcaaca acaactgggg attccggccc aagaagctca acttcaagct gttcaacatc      960

caggtcaagg aggtcacaac gaatgacggc gtcacgacca tcgccaataa ccttaccagc     1020

acggttcagg tcttttcgga ctcggaatac cagctgccct acgtcctcgg ctccgcacac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttccccagta cggctacctg     1140

actctgaaca atggcagcca atcggtgggt cgttcctctt tctactgcct ggaatatttc     1200

ccttctcaaa tgctgagaac gggcaacaac ttcaccttca gctacacctt cgaggacgtt     1260

cccttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcctcttatc     1320

gaccagtacc tgtattacct ggccagaaca cagagcaacg caggaggcac agctggcaat     1380

cgggaactgc agttttatca gggcgggcct accaccatgg ccgaacaagc caaaaactgg     1440

ctgcctagac cttgcttccg gcaacaaaga gtctccaaga cgctggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa taccatctaa atggaagaaa ttcattggtt     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccttcgagc     1620

ggagtcctga tttttggaaa aactggagca gctaataaga ctacactgga aaatgtgtta     1680

atgacaaatg aagaggaaat tcgtcctacc aacccggtag ccaccgagga atacgggact     1740

gttagcagca acctgcaggc ggctaacact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttt cacccgtctc cgctgatggg cggctttgga     1920

ctgaagcatc cgcctcctca gatcctgatc aaaaacactc ctgttcctgc taatcccccg     1980

gaggtgttta cgcctgccaa gtttgcttct ttcatcacac agtacagcac cggccaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gagaacagca agcgctggaa cccagagatt     2100

cagtatacct ccaattttga caaacagact ggtgtggact ttgccgttga cagccagggt     2160

gtttattctg agcctcgccc cattggtact cgttacctca cccgtaatct gtaa           2214


<210>  492
<211>  737
<212>  PRT
<213>  Adeno-associated virus

<400>  492

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Arg Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  493
<211>  2214
<212>  DNA
<213>  Adeno-associated virus

<400>  493
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accatgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcctccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggctttg cccacctaca acaaccacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcgg      900

ctcatcaaca acaactgggg attccggccc aagaagctca acttcaagct gttcaacatc      960

caggtcaagg aggtcacaac gaatgacggc gtcacgacca tcgccaataa ccttaccagc     1020

acggttcagg tcttttcgga ctcggaatac cagctgccct acgtcctcgg ctccgcacac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttccccagta cggctacctg     1140

actctgaaca atggcagcca atcggtgggt cgttcctctt tctactgcct ggaatatttc     1200

ccttctcaaa tgctgagaac gggcaacaac ttcaccttca gctacacctt cgaggacgtt     1260

cccttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcctcttatc     1320

gaccagtacc tgtattacct ggccagaaca cagagcaacg caggaggcac agctggcaat     1380

cgggaactgc agttttatca gggcgggcct accaccatgg ccgaacaagc caaaaactgg     1440

ctgcctggac cttgcttccg gcaacaaaga gtctccaaga cgctggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa taccatctaa atggaagaaa ttcattggtt     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccttcgagc     1620

ggagtcctga tttttggaaa aactggagca gctaataaga ctacactgga aaatgtgtta     1680

atgacaaatg aagaggaaat tcgtcctacc aacccggtag ccaccgagga atacgggact     1740

gttagcagca acctgcaggc ggctaacact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttt cacccgtctc cgctgatggg cggctttgga     1920

ctgaagcatc cgcctcctca gatcctgatc aaaaacactc ctgttcctgc taatcccccg     1980

gaggtgttta cgcctgccaa gtttgcttct ttcatcacac agtacagcac cggccaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gagaacagca agcgctggaa cccagagatt     2100

cagtatacct ccaattttga caaacagact ggtgtggact ttgccgttga cagccagggt     2160

gtttattctg agcctcgccc cattggtact cgttacctca cccgtaatct gtaa           2214


<210>  494
<211>  737
<212>  PRT
<213>  Adeno-associated virus

<400>  494

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  495
<211>  737
<212>  PRT
<213>  Adeno-associated virus

<400>  495

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Leu Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  496
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  496
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccacccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg tgatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcttcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210>  497
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  497

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Pro Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Val Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Leu Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  498
<211>  2214
<212>  DNA
<213>  Adeno-associated virus

<400>  498
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgcc ccaatggcag acaataacga aggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggctttg cccacctaca acaaccacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcgg      900

ctcatcaaca acaactgggg attccggccc aagaagctca acttcaagct gttcaacatc      960

caggtcaagg aggtcacaac gaatgacggc gtcacgacca tcgccaataa ccttaccagc     1020

acggttcagg tcttttcgga ctcggaatac cagctgccct acgtcctcgg ctccgcacac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttccccagta cggctacctg     1140

actctgaaca atggcagcca atcggtgggt cgttcctctt tctactgcct ggaatatttc     1200

ccttctcaaa tgctgagaac gggcaacaac ttcaccatca gctacacctt cgaggacgtt     1260

cccttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcctcttatc     1320

gaccagtacc tgtattacct ggccagaaca cagagcaacg caggaggcac agctggcaat     1380

caggaactgc agttttatca gggcgggcct accaccatgg ccgaacaagc caaaaactgg     1440

ctgcctggac cttgcttccg gcaacaaaga gtctccaaga cgctggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa taccatctaa atggaagaaa ttcattggtt     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccttcgagc     1620

ggagtcctga tttttggaaa aactggagca gctaataaga ctacactgga aaatgtgtta     1680

atgacaaatg aagaggaaat tcgtcctacc aacccggtag ccaccgagga atacgggact     1740

gttagcagca acctgcaggc ggctaacact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacaga tggcaacttt cacccgtctc ctttaatggg cggctttgga     1920

cttaaacatc cgcctcctca gatcctcatc aaaaacactc ctgttcctgc ggatcctcca     1980

acagcgttca accaggccaa gctgaattct ttcatcacgc agtacagcac cggacaagtc     2040

agcgtggaga tcgagtggga gctgcagaag gagaacagca agcgctggaa cccagagatt     2100

cagtatactt ccaactacta caaatctaca aatgtggact ttgctgttaa tactgagggt     2160

gtttactctg agcctcgccc cattggcact cgttacctca cccgtaatct gtaa           2214


<210>  499
<211>  737
<212>  PRT
<213>  Adeno-associated virus

<400>  499

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Ile Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Gln Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  500
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  500
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccgcctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gatgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga gcggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tcttccatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tttgtaa        2217


<210>  501
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  501

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Ala Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Ser Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Ser 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  502
<211>  736
<212>  PRT
<213>  Adeno-associated virus

<400>  502

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  503
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  503
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattttgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccgtcgagt     1620

ggagtcctga tgtttggaaa acagggtgct ggaagagaca atgtggacta cagcagcgtt     1680

atgctaacca gcgaagaaga aattaaaacc actaaccctg tagccacaga acaatacggt     1740

gtggtggctg acaacttgca gcaaaccaat acagggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccaccctt caccgctaat gggaggattt     1920

ggactgaagc acccacctcc tcagatcctg atcaagaaca cgccggtacc tgcggatcct     1980

ccaacaacgt tcagccaggc gaaattggct tccttcatta cgcagtacag caccggacag     2040

gtcagcgtgg aaatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaacccagag     2100

attcagtaca cttcaaacta ctacaaatct acaaatgtgg actttgctgt caatacagag     2160

ggaacttatt ctgagcctcg ccccattggt actcgttacc tcacccgtaa tctgtaa        2217


<210>  504
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  504

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Arg Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  505
<211>  736
<212>  PRT
<213>  Adeno-associated virus

<400>  505

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Leu Asn Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Asp Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Gly 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Lys Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Thr Pro Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Ser Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Ser Pro His Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Glu Ala Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ser Asp Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys 
        435                 440                 445             


Thr Gln Gly Thr Asn Ala Thr Val Gln Gly Ala Lys Leu Gln Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Asn Met Arg Asp Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Glu Tyr Ala Trp Thr Gly Ala Thr Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met Asn Gly Thr Leu Val Phe Gly 
    530                 535                 540                 


Lys Asn Gly Ala Gly Asn Ser Asn Val Asp Ile Glu Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Val Val Ser Asp Asn Leu Gln Ser Ser Asn Thr Arg Pro Ile 
            580                 585                 590         


Thr Gly Asp Val Asp Ser Gln Gly Val Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Ala Thr Thr Phe Thr Pro Gly Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Gln Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  506
<211>  736
<212>  PRT
<213>  Adeno-associated virus

<400>  506

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Asp Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  507
<211>  736
<212>  PRT
<213>  Adeno-associated virus

<400>  507

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  508
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  508

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  509
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  509

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Arg Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  510
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  510

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Ala Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  511
<211>  1803
<212>  DNA
<213>  Bovine adeno-associated virus

<400>  511
acggcgcctg cggcaaaaaa gaggcctcta gagcagagtc ctcaagagcc agactcctcg       60

agcggagttg gcaagaaagg caaacagcct gccagaaaga gactcaactt tgacgacgaa      120

cctggagccg gagacgggcc tcccccagaa ggaccatctt ccggagctat gtctactgag      180

actgaaatgc gtgcagcagc tggcggaaat ggtggcgatg cgggacaagg tgccgaggga      240

gtgggtaatg cctccggtga ttggcattgc gattccactt ggtcagagag ccacgtcacc      300

accacctcaa cccgcacctg ggtcctgccg acctacaaca accacctgta cctgcggctc      360

ggctcgagca acgccagcga caccttcaac ggattctcca ccccctgggg atactttgac      420

tttaaccgct tccactgcca cttctcgcca agagactggc aaaggctcat caacaaccac      480

tggggactgc gccccaaaag catgcaagtc cgcatcttca acatccaagt taaggaggtc      540

acgacgtcta acggggagac gaccgtatcc aacaacctca ccagcacggt ccagatcttt      600

gcggacagca cgtacgagct cccgtacgtg atggatgcag gtcaggaggg cagcttgcct      660

cctttcccca acgacgtgtt catggtgcct cagtacgggt actgcggact ggtaaccgga      720

ggcagctctc aaaaccagac agacagaaat gccttctact gtctggagta ctttcccagc      780

cagatgctga gaaccggaaa caactttgag atggtgtaca agtttgaaaa cgtgcccttc      840

cactccatgt acgctcacag ccagagcctg gataggctga tgaacccgct gctggaccag      900

tacctgtggg agctccagtc taccacctct ggaggaactc tcaaccaggg caattcagcc      960

accaactttg ccaagctgac caaaacaaac ttttctggct accgcaaaaa ctggctcccg     1020

gggcccatga tgaagcagca gagattctcc aagactgcca gtcaaaacta caagattccc     1080

cagggaagaa acaacagtct gctccattat gagaccagaa ctaccctcga cggaagatgg     1140

agcaattttg ccccgggaac ggccatggca accgcagcca acgacgccac cgacttctct     1200

caggcccagc tcatctttgc ggggcccaac atcaccggca acaccaccac agatgccaat     1260

aacctgatgt tcacttcaga agatgaactt agggccacca acccccggga cactgacctg     1320

tttggccacc tggcaaccaa ccagcaaaac gccaccaccg ttcctaccgt agacgacgtg     1380

gacggagtcg gcgtgtaccc gggaatggtg tggcaggaca gagacattta ctaccaaggg     1440

cccatttggg ccaaaattcc acacacggat ggacactttc acccgtctcc tctcattggc     1500

ggatttggac tgaaaagccc gcctccacaa atattcatca aaaacactcc tgtacccgcc     1560

aatcccgcaa cgaccttctc tccggccaga atcaacagct tcatcaccca gtacagcacc     1620

ggacaggtgg ctgtcaaaat agaatgggaa atccagaagg agcggtccaa gagatggaac     1680

ccagaggtcc agttcacgtc caactacgga gcacaggact cgcttctctg ggctcccgac     1740

aacgccggag cctacaaaga gcccagggcc attggatccc gatacctcac caaccacctc     1800

tag                                                                   1803


<210>  512
<211>  1617
<212>  DNA
<213>  Bovine adeno-associated virus

<400>  512
atgcgtgcag cagctggcgg aaatggtggc gatgcgggac aaggtgccga gggagtgggt       60

aatgcctccg gtgattggca ttgcgattcc acttggtcag agagccacgt caccaccacc      120

tcaacccgca cctgggtcct gccgacctac aacaaccacc tgtacctgcg gctcggctcg      180

agcaacgcca gcgacacctt caacggattc tccaccccct ggggatactt tgactttaac      240

cgcttccact gccacttctc gccaagagac tggcaaaggc tcatcaacaa ccactgggga      300

ctgcgcccca aaagcatgca agtccgcatc ttcaacatcc aagttaagga ggtcacgacg      360

tctaacgggg agacgaccgt atccaacaac ctcaccagca cggtccagat ctttgcggac      420

agcacgtacg agctcccgta cgtgatggat gcaggtcagg agggcagctt gcctcctttc      480

cccaacgacg tgttcatggt gcctcagtac gggtactgcg gactggtaac cggaggcagc      540

tctcaaaacc agacagacag aaatgccttc tactgtctgg agtactttcc cagccagatg      600

ctgagaaccg gaaacaactt tgagatggtg tacaagtttg aaaacgtgcc cttccactcc      660

atgtacgctc acagccagag cctggatagg ctgatgaacc cgctgctgga ccagtacctg      720

tgggagctcc agtctaccac ctctggagga actctcaacc agggcaattc agccaccaac      780

tttgccaagc tgaccaaaac aaacttttct ggctaccgca aaaactggct cccggggccc      840

atgatgaagc agcagagatt ctccaagact gccagtcaaa actacaagat tccccaggga      900

agaaacaaca gtctgctcca ttatgagacc agaactaccc tcgacggaag atggagcaat      960

tttgccccgg gaacggccat ggcaaccgca gccaacgacg ccaccgactt ctctcaggcc     1020

cagctcatct ttgcggggcc caacatcacc ggcaacacca ccacagatgc caataacctg     1080

atgttcactt cagaagatga acttagggcc accaaccccc gggacactga cctgtttggc     1140

cacctggcaa ccaaccagca aaacgccacc accgttccta ccgtagacga cgtggacgga     1200

gtcggcgtgt acccgggaat ggtgtggcag gacagagaca tttactacca agggcccatt     1260

tgggccaaaa ttccacacac ggatggacac tttcacccgt ctcctctcat tggcggattt     1320

ggactgaaaa gcccgcctcc acaaatattc atcaaaaaca ctcctgtacc cgccaatccc     1380

gcaacgacct tctctccggc cagaatcaac agcttcatca cccagtacag caccggacag     1440

gtggctgtca aaatagaatg ggaaatccag aaggagcggt ccaagagatg gaacccagag     1500

gtccagttca cgtccaacta cggagcacag gactcgcttc tctgggctcc cgacaacgcc     1560

ggagcctaca aagagcccag ggccattgga tcccgatacc tcaccaacca cctctag        1617


<210>  513
<211>  1173
<212>  DNA
<213>  Bovine adeno-associated virus

<400>  513
atggcgctgg taagctggct ggtggaacat ggcatcactt ccgagaagca gtggattcag       60

gagaatcagg agagctacct gtccttcaac tccacgggaa actctcggag ccagattaaa      120

gccgcgcttg acaacgcgtc aaaaattatg agtctgacca aatctgcctc agactatctc      180

gtgggacaga ctgttccaga ggacatttct gaaaacagaa tctggcagat ttttgatctc      240

aacggctacg acccggcata cgcgggctct gttctctacg gctggtgcac tcgcgccttt      300

ggaaagagga acaccgtctg gctgtatgga cccgcgacca ccggaaagac caacatcgcg      360

gaagccatct ctcacaccgt gcccttttat ggctgtgtga actggactaa tgagaacttt      420

ccctttaatg actgtgtgga aaaaatgttg atctggtggg aggagggaaa gatgaccagc      480

aaggtggtgg aacccgccaa ggccatcttg ggggggtcta gagtacgagt ggatcaaaaa      540

tgtaaatcct ctgtacaagt agactctacc ccggtgatta tcacctccaa tactaacatg      600

tgtgtggtgg tggatgggaa ctccacgacc tttgaacacc agcagccgct ggaagaccgc      660

atgttcagat ttgaactcat gcggcggctc ccgccagatt ttggcaagat taccaagcag      720

gaagtcaaag acttttttgc ttgggcaaag gtcaaccagg tgccggtgac tcacgagttt      780

atggttccca agaaagtggc gggaactgag agggcggaga cttctagaaa acgcccactg      840

gatgacgtca ccaataccaa ctataaaagt ccggagaagc gggcccggct ctcagttgtt      900

cctgagacgc ctcgcagttc agacgtgcct gtagagcccg ctcctctgcg acctctcaac      960

tggtcttcca ggtatgaatg cagatgtgac tatcatgcta aatttgactc tgtaacgggg     1020

gaatgtgacg agtgtgaata tttgaatcgg ggcaaaaatg gctgtatctt tcataatgct     1080

acacattgtc aaatttgtca cgctgttcct ccatgggaaa aggaaaatgt gtcagatttt     1140

aatgattttg atgactgtaa taaagagcag taa                                  1173


<210>  514
<211>  1833
<212>  DNA
<213>  Bovine adeno-associated virus

<400>  514
atggctacct tctatgaagt cattgttcgc gttccatttg atgtggaaga gcacctgcct       60

ggaatttctg acaactttgt agactgggta actggtcaaa tttgggagct gcctcccgag      120

tcagatttga atttgactct gattgagcag cctcagctga cggtggctga cagaattcgc      180

cgcgtgttcc tgtacgagtg gaacaaattt tccaagcagg agagcaaatt ctttgtgcag      240

tttgaaaagg gatctgaata ttttcatctg cacacgctcg tggagacctc cggcatctct      300

tctatggtcc ttggccgcta cgtgagtcag attcgcgccc agctggtgaa ggtggtgttc      360

cagaacattg agccgcggat taacgactgg gtcgccatca ccaaggtaaa gaagggcgga      420

gccaataagg tggtggattc tgggtatatt cccgcctacc tgctgccgaa ggtccaacca      480

gagcttcagt gggcgtggac taacctcgaa gagtataaat tggccgccct caatctggag      540

gagcgcaaac ggctcgtcgc tcagtttcag cttgagtcct cgcagcgctc gcaagaggca      600

tcttcccaga gggacgtttc ggctgacccg gtcatcaaga gcaagacttc ccagaaatac      660

atggcgctgg taagctggct ggtggaacat ggcatcactt ccgagaagca gtggattcag      720

gagaatcagg agagctacct gtccttcaac tccacgggaa actctcggag ccagattaaa      780

gccgcgcttg acaacgcgtc aaaaattatg agtctgacca aatctgcctc agactatctc      840

gtgggacaga ctgttccaga ggacatttct gaaaacagaa tctggcagat ttttgatctc      900

aacggctacg acccggcata cgcgggctct gttctctacg gctggtgcac tcgcgccttt      960

ggaaagagga acaccgtctg gctgtatgga cccgcgacca ccggaaagac caacatcgcg     1020

gaagccatct ctcacaccgt gcccttttat ggctgtgtga actggactaa tgagaacttt     1080

ccctttaatg actgtgtgga aaaaatgttg atctggtggg aggagggaaa gatgaccagc     1140

aaggtggtgg aacccgccaa ggccatcttg ggggggtcta gagtacgagt ggatcaaaaa     1200

tgtaaatcct ctgtacaagt agactctacc ccggtgatta tcacctccaa tactaacatg     1260

tgtgtggtgg tggatgggaa ctccacgacc tttgaacacc agcagccgct ggaagaccgc     1320

atgttcagat ttgaactcat gcggcggctc ccgccagatt ttggcaagat taccaagcag     1380

gaagtcaaag acttttttgc ttgggcaaag gtcaaccagg tgccggtgac tcacgagttt     1440

atggttccca agaaagtggc gggaactgag agggcggaga cttctagaaa acgcccactg     1500

gatgacgtca ccaataccaa ctataaaagt ccggagaagc gggcccggct ctcagttgtt     1560

cctgagacgc ctcgcagttc agacgtgcct gtagagcccg ctcctctgcg acctctcaac     1620

tggtcttcca ggtatgaatg cagatgtgac tatcatgcta aatttgactc tgtaacgggg     1680

gaatgtgacg agtgtgaata tttgaatcgg ggcaaaaatg gctgtatctt tcataatgct     1740

acacattgtc aaatttgtca cgctgttcct ccatgggaaa aggaaaatgt gtcagatttt     1800

aatgattttg atgactgtaa taaagagcag taa                                  1833


<210>  515
<211>  2211
<212>  DNA
<213>  Bovine adeno-associated virus

<400>  515
atgtcttttg ttgaccaccc tccagattgg ttggaatcga tcggcgacgg ctttcgtgaa       60

tttctcggcc ttgaggcggg tcccccgaaa cccaaggcca atcaacagaa gcaagataac      120

gctcgaggtc ttgtgcttcc tgggtacaag tatcttggtc ctgggaacgg ccttgataag      180

ggcgatcctg tcaattttgc tgacgaggtt gcccgagagc acgacctctc ctaccagaaa      240

cagcttgagg cgggcgataa cccttacctc aagtacaacc acgcggacgc agagtttcag      300

gagaaactcg cttctgacac ttcttttggg ggaaaccttg ggaaggctgt tttccaggct      360

aaaaagagga ttctcgaacc tcttggcctg gttgagacgc cggataaaac ggcgcctgcg      420

gcaaaaaaga ggcctctaga gcagagtcct caagagccag actcctcgag cggagttggc      480

aagaaaggca aacagcctgc cagaaagaga ctcaactttg acgacgaacc tggagccgga      540

gacgggcctc ccccagaagg accatcttcc ggagctatgt ctactgagac tgaaatgcgt      600

gcagcagctg gcggaaatgg tggcgatgcg ggacaaggtg ccgagggagt gggtaatgcc      660

tccggtgatt ggcattgcga ttccacttgg tcagagagcc acgtcaccac cacctcaacc      720

cgcacctggg tcctgccgac ctacaacaac cacctgtacc tgcggctcgg ctcgagcaac      780

gccagcgaca ccttcaacgg attctccacc ccctggggat actttgactt taaccgcttc      840

cactgccact tctcgccaag agactggcaa aggctcatca acaaccactg gggactgcgc      900

cccaaaagca tgcaagtccg catcttcaac atccaagtta aggaggtcac gacgtctaac      960

ggggagacga ccgtatccaa caacctcacc agcacggtcc agatctttgc ggacagcacg     1020

tacgagctcc cgtacgtgat ggatgcaggt caggagggca gcttgcctcc tttccccaac     1080

gacgtgttca tggtgcctca gtacgggtac tgcggactgg taaccggagg cagctctcaa     1140

aaccagacag acagaaatgc cttctactgt ctggagtact ttcccagcca gatgctgaga     1200

accggaaaca actttgagat ggtgtacaag tttgaaaacg tgcccttcca ctccatgtac     1260

gctcacagcc agagcctgga taggctgatg aacccgctgc tggaccagta cctgtgggag     1320

ctccagtcta ccacctctgg aggaactctc aaccagggca attcagccac caactttgcc     1380

aagctgacca aaacaaactt ttctggctac cgcaaaaact ggctcccggg gcccatgatg     1440

aagcagcaga gattctccaa gactgccagt caaaactaca agattcccca gggaagaaac     1500

aacagtctgc tccattatga gaccagaact accctcgacg gaagatggag caattttgcc     1560

ccgggaacgg ccatggcaac cgcagccaac gacgccaccg acttctctca ggcccagctc     1620

atctttgcgg ggcccaacat caccggcaac accaccacag atgccaataa cctgatgttc     1680

acttcagaag atgaacttag ggccaccaac ccccgggaca ctgacctgtt tggccacctg     1740

gcaaccaacc agcaaaacgc caccaccgtt cctaccgtag acgacgtgga cggagtcggc     1800

gtgtacccgg gaatggtgtg gcaggacaga gacatttact accaagggcc catttgggcc     1860

aaaattccac acacggatgg acactttcac ccgtctcctc tcattggcgg atttggactg     1920

aaaagcccgc ctccacaaat attcatcaaa aacactcctg tacccgccaa tcccgcaacg     1980

accttctctc cggccagaat caacagcttc atcacccagt acagcaccgg acaggtggct     2040

gtcaaaatag aatgggaaat ccagaaggag cggtccaaga gatggaaccc agaggtccag     2100

ttcacgtcca actacggagc acaggactcg cttctctggg ctcccgacaa cgccggagcc     2160

tacaaagagc ccagggccat tggatcccga tacctcacca accacctcta g              2211


<210>  516
<211>  4694
<212>  DNA
<213>  Bovine adeno-associated virus

<400>  516
gtggcactcc cccccctgtc gcgttcgctc gttcgctggc tcgattgggg gggtggcagc       60

tcaaagagct gccagacgac ggccctctgg gccgtcgccc ccccaatcga gccagcgaac      120

gagcgaacgc gacagggggg ggagtgccac actctctagc aagggggttt tgtaggtggt      180

gatgtcattg ttgatgtcat tatagttgtc acgcgatagt taatgattaa cagtcatgtg      240

atgtgtgtta tccaatagga tgaaagcgcg cgaatgagat ctcgcgagac ttccggggta      300

taaaaggggt gagtgaacga gcccgccgcc attctctgct ctggactgct agaggaccct      360

cgctgccatg gctaccttct atgaagtcat tgttcgcgtt ccatttgatg tggaagagca      420

cctgcctgga atttctgaca actttgtaga ctgggtaact ggtcaaattt gggagctgcc      480

tcccgagtca gatttgaatt tgactctgat tgagcagcct cagctgacgg tggctgacag      540

aattcgccgc gtgttcctgt acgagtggaa caaattttcc aagcaggaga gcaaattctt      600

tgtgcagttt gaaaagggat ctgaatattt tcatctgcac acgctcgtgg agacctccgg      660

catctcttct atggtccttg gccgctacgt gagtcagatt cgcgcccagc tggtgaaggt      720

ggtgttccag aacattgagc cgcggattaa cgactgggtc gccatcacca aggtaaagaa      780

gggcggagcc aataaggtgg tggattctgg gtatattccc gcctacctgc tgccgaaggt      840

ccaaccagag cttcagtggg cgtggactaa cctcgaagag tataaattgg ccgccctcaa      900

tctggaggag cgcaaacggc tcgtcgctca gtttcagctt gagtcctcgc agcgctcgca      960

agaggcatct tcccagaggg acgtttcggc tgacccggtc atcaagagca agacttccca     1020

gaaatacatg gcgctggtaa gctggctggt ggaacatggc atcacttccg agaagcagtg     1080

gattcaggag aatcaggaga gctacctgtc cttcaactcc acgggaaact ctcggagcca     1140

gattaaagcc gcgcttgaca acgcgtcaaa aattatgagt ctgaccaaat ctgcctcaga     1200

ctatctcgtg ggacagactg ttccagagga catttctgaa aacagaatct ggcagatttt     1260

tgatctcaac ggctacgacc cggcatacgc gggctctgtt ctctacggct ggtgcactcg     1320

cgcctttgga aagaggaaca ccgtctggct gtatggaccc gcgaccaccg gaaagaccaa     1380

catcgcggaa gccatctctc acaccgtgcc cttttatggc tgtgtgaact ggactaatga     1440

gaactttccc tttaatgact gtgtggaaaa aatgttgatc tggtgggagg agggaaagat     1500

gaccagcaag gtggtggaac ccgccaaggc catcttgggg gggtctagag tacgagtgga     1560

tcaaaaatgt aaatcctctg tacaagtaga ctctaccccg gtgattatca cctccaatac     1620

taacatgtgt gtggtggtgg atgggaactc cacgaccttt gaacaccagc agccgctgga     1680

agaccgcatg ttcagatttg aactcatgcg gcggctcccg ccagattttg gcaagattac     1740

caagcaggaa gtcaaagact tttttgcttg ggcaaaggtc aaccaggtgc cggtgactca     1800

cgagtttatg gttcccaaga aagtggcggg aactgagagg gcggagactt ctagaaaacg     1860

cccactggat gacgtcacca ataccaacta taaaagtccg gagaagcggg cccggctctc     1920

agttgttcct gagacgcctc gcagttcaga cgtgcctgta gagcccgctc ctctgcgacc     1980

tctcaactgg tcttccaggt atgaatgcag atgtgactat catgctaaat ttgactctgt     2040

aacgggggaa tgtgacgagt gtgaatattt gaatcggggc aaaaatggct gtatctttca     2100

taatgctaca cattgtcaaa tttgtcacgc tgttcctcca tgggaaaagg aaaatgtgtc     2160

agattttaat gattttgatg actgtaataa agagcagtaa ataaagtgag tagtcatgtc     2220

ttttgttgac caccctccag attggttgga atcgatcggc gacggctttc gtgaatttct     2280

cggccttgag gcgggtcccc cgaaacccaa ggccaatcaa cagaagcaag ataacgctcg     2340

aggtcttgtg cttcctgggt acaagtatct tggtcctggg aacggccttg ataagggcga     2400

tcctgtcaat tttgctgacg aggttgcccg agagcacgac ctctcctacc agaaacagct     2460

tgaggcgggc gataaccctt acctcaagta caaccacgcg gacgcagagt ttcaggagaa     2520

actcgcttct gacacttctt ttgggggaaa ccttgggaag gctgttttcc aggctaaaaa     2580

gaggattctc gaacctcttg gcctggttga gacgccggat aaaacggcgc ctgcggcaaa     2640

aaagaggcct ctagagcaga gtcctcaaga gccagactcc tcgagcggag ttggcaagaa     2700

aggcaaacag cctgccagaa agagactcaa ctttgacgac gaacctggag ccggagacgg     2760

gcctccccca gaaggaccat cttccggagc tatgtctact gagactgaaa tgcgtgcagc     2820

agctggcgga aatggtggcg atgcgggaca aggtgccgag ggagtgggta atgcctccgg     2880

tgattggcat tgcgattcca cttggtcaga gagccacgtc accaccacct caacccgcac     2940

ctgggtcctg ccgacctaca acaaccacct gtacctgcgg ctcggctcga gcaacgccag     3000

cgacaccttc aacggattct ccaccccctg gggatacttt gactttaacc gcttccactg     3060

ccacttctcg ccaagagact ggcaaaggct catcaacaac cactggggac tgcgccccaa     3120

aagcatgcaa gtccgcatct tcaacatcca agttaaggag gtcacgacgt ctaacgggga     3180

gacgaccgta tccaacaacc tcaccagcac ggtccagatc tttgcggaca gcacgtacga     3240

gctcccgtac gtgatggatg caggtcagga gggcagcttg cctcctttcc ccaacgacgt     3300

gttcatggtg cctcagtacg ggtactgcgg actggtaacc ggaggcagct ctcaaaacca     3360

gacagacaga aatgccttct actgtctgga gtactttccc agccagatgc tgagaaccgg     3420

aaacaacttt gagatggtgt acaagtttga aaacgtgccc ttccactcca tgtacgctca     3480

cagccagagc ctggataggc tgatgaaccc gctgctggac cagtacctgt gggagctcca     3540

gtctaccacc tctggaggaa ctctcaacca gggcaattca gccaccaact ttgccaagct     3600

gaccaaaaca aacttttctg gctaccgcaa aaactggctc ccggggccca tgatgaagca     3660

gcagagattc tccaagactg ccagtcaaaa ctacaagatt ccccagggaa gaaacaacag     3720

tctgctccat tatgagacca gaactaccct cgacggaaga tggagcaatt ttgccccggg     3780

aacggccatg gcaaccgcag ccaacgacgc caccgacttc tctcaggccc agctcatctt     3840

tgcggggccc aacatcaccg gcaacaccac cacagatgcc aataacctga tgttcacttc     3900

agaagatgaa cttagggcca ccaacccccg ggacactgac ctgtttggcc acctggcaac     3960

caaccagcaa aacgccacca ccgttcctac cgtagacgac gtggacggag tcggcgtgta     4020

cccgggaatg gtgtggcagg acagagacat ttactaccaa gggcccattt gggccaaaat     4080

tccacacacg gatggacact ttcacccgtc tcctctcatt ggcggatttg gactgaaaag     4140

cccgcctcca caaatattca tcaaaaacac tcctgtaccc gccaatcccg caacgacctt     4200

ctctccggcc agaatcaaca gcttcatcac ccagtacagc accggacagg tggctgtcaa     4260

aatagaatgg gaaatccaga aggagcggtc caagagatgg aacccagagg tccagttcac     4320

gtccaactac ggagcacagg actcgcttct ctgggctccc gacaacgccg gagcctacaa     4380

agagcccagg gccattggat cccgatacct caccaaccac ctctagccca attctgttgc     4440

ataccctcaa taaaccgtgt attcgtttca gtaaaatact gcctcttgtg gtcattcggc     4500

gtacaacagc ttacaacaac aacaaaaccc ccttgctaga gagtgtggca ctcccccccc     4560

tgtcgcgttc gctcgttcgc tggctcgatt gggggggtgg cagctcaaag agctgccaga     4620

cgacggccct ctgggccgtc gcccccccaa tcgagccagc gaacgagcga acgcgacagg     4680

ggggggagtg ccac                                                       4694


<210>  517
<211>  390
<212>  PRT
<213>  Bovine adeno-associated virus

<400>  517

Met Ala Leu Val Ser Trp Leu Val Glu His Gly Ile Thr Ser Glu Lys 
1               5                   10                  15      


Gln Trp Ile Gln Glu Asn Gln Glu Ser Tyr Leu Ser Phe Asn Ser Thr 
            20                  25                  30          


Gly Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Ser Lys 
        35                  40                  45              


Ile Met Ser Leu Thr Lys Ser Ala Ser Asp Tyr Leu Val Gly Gln Thr 
    50                  55                  60                  


Val Pro Glu Asp Ile Ser Glu Asn Arg Ile Trp Gln Ile Phe Asp Leu 
65                  70                  75                  80  


Asn Gly Tyr Asp Pro Ala Tyr Ala Gly Ser Val Leu Tyr Gly Trp Cys 
                85                  90                  95      


Thr Arg Ala Phe Gly Lys Arg Asn Thr Val Trp Leu Tyr Gly Pro Ala 
            100                 105                 110         


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ser His Thr Val Pro 
        115                 120                 125             


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
    130                 135                 140                 


Cys Val Glu Lys Met Leu Ile Trp Trp Glu Glu Gly Lys Met Thr Ser 
145                 150                 155                 160 


Lys Val Val Glu Pro Ala Lys Ala Ile Leu Gly Gly Ser Arg Val Arg 
                165                 170                 175     


Val Asp Gln Lys Cys Lys Ser Ser Val Gln Val Asp Ser Thr Pro Val 
            180                 185                 190         


Ile Ile Thr Ser Asn Thr Asn Met Cys Val Val Val Asp Gly Asn Ser 
        195                 200                 205             


Thr Thr Phe Glu His Gln Gln Pro Leu Glu Asp Arg Met Phe Arg Phe 
    210                 215                 220                 


Glu Leu Met Arg Arg Leu Pro Pro Asp Phe Gly Lys Ile Thr Lys Gln 
225                 230                 235                 240 


Glu Val Lys Asp Phe Phe Ala Trp Ala Lys Val Asn Gln Val Pro Val 
                245                 250                 255     


Thr His Glu Phe Met Val Pro Lys Lys Val Ala Gly Thr Glu Arg Ala 
            260                 265                 270         


Glu Thr Ser Arg Lys Arg Pro Leu Asp Asp Val Thr Asn Thr Asn Tyr 
        275                 280                 285             


Lys Ser Pro Glu Lys Arg Ala Arg Leu Ser Val Val Pro Glu Thr Pro 
    290                 295                 300                 


Arg Ser Ser Asp Val Pro Val Glu Pro Ala Pro Leu Arg Pro Leu Asn 
305                 310                 315                 320 


Trp Ser Ser Arg Tyr Glu Cys Arg Cys Asp Tyr His Ala Lys Phe Asp 
                325                 330                 335     


Ser Val Thr Gly Glu Cys Asp Glu Cys Glu Tyr Leu Asn Arg Gly Lys 
            340                 345                 350         


Asn Gly Cys Ile Phe His Asn Ala Thr His Cys Gln Ile Cys His Ala 
        355                 360                 365             


Val Pro Pro Trp Glu Lys Glu Asn Val Ser Asp Phe Asn Asp Phe Asp 
    370                 375                 380                 


Asp Cys Asn Lys Glu Gln 
385                 390 


<210>  518
<211>  610
<212>  PRT
<213>  Bovine adeno-associated virus

<400>  518

Met Ala Thr Phe Tyr Glu Val Ile Val Arg Val Pro Phe Asp Val Glu 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Asn Phe Val Asp Trp Val Thr Gly 
            20                  25                  30          


Gln Ile Trp Glu Leu Pro Pro Glu Ser Asp Leu Asn Leu Thr Leu Ile 
        35                  40                  45              


Glu Gln Pro Gln Leu Thr Val Ala Asp Arg Ile Arg Arg Val Phe Leu 
    50                  55                  60                  


Tyr Glu Trp Asn Lys Phe Ser Lys Gln Glu Ser Lys Phe Phe Val Gln 
65                  70                  75                  80  


Phe Glu Lys Gly Ser Glu Tyr Phe His Leu His Thr Leu Val Glu Thr 
                85                  90                  95      


Ser Gly Ile Ser Ser Met Val Leu Gly Arg Tyr Val Ser Gln Ile Arg 
            100                 105                 110         


Ala Gln Leu Val Lys Val Val Phe Gln Asn Ile Glu Pro Arg Ile Asn 
        115                 120                 125             


Asp Trp Val Ala Ile Thr Lys Val Lys Lys Gly Gly Ala Asn Lys Val 
    130                 135                 140                 


Val Asp Ser Gly Tyr Ile Pro Ala Tyr Leu Leu Pro Lys Val Gln Pro 
145                 150                 155                 160 


Glu Leu Gln Trp Ala Trp Thr Asn Leu Glu Glu Tyr Lys Leu Ala Ala 
                165                 170                 175     


Leu Asn Leu Glu Glu Arg Lys Arg Leu Val Ala Gln Phe Gln Leu Glu 
            180                 185                 190         


Ser Ser Gln Arg Ser Gln Glu Ala Ser Ser Gln Arg Asp Val Ser Ala 
        195                 200                 205             


Asp Pro Val Ile Lys Ser Lys Thr Ser Gln Lys Tyr Met Ala Leu Val 
    210                 215                 220                 


Ser Trp Leu Val Glu His Gly Ile Thr Ser Glu Lys Gln Trp Ile Gln 
225                 230                 235                 240 


Glu Asn Gln Glu Ser Tyr Leu Ser Phe Asn Ser Thr Gly Asn Ser Arg 
                245                 250                 255     


Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Ser Lys Ile Met Ser Leu 
            260                 265                 270         


Thr Lys Ser Ala Ser Asp Tyr Leu Val Gly Gln Thr Val Pro Glu Asp 
        275                 280                 285             


Ile Ser Glu Asn Arg Ile Trp Gln Ile Phe Asp Leu Asn Gly Tyr Asp 
    290                 295                 300                 


Pro Ala Tyr Ala Gly Ser Val Leu Tyr Gly Trp Cys Thr Arg Ala Phe 
305                 310                 315                 320 


Gly Lys Arg Asn Thr Val Trp Leu Tyr Gly Pro Ala Thr Thr Gly Lys 
                325                 330                 335     


Thr Asn Ile Ala Glu Ala Ile Ser His Thr Val Pro Phe Tyr Gly Cys 
            340                 345                 350         


Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp Cys Val Glu Lys 
        355                 360                 365             


Met Leu Ile Trp Trp Glu Glu Gly Lys Met Thr Ser Lys Val Val Glu 
    370                 375                 380                 


Pro Ala Lys Ala Ile Leu Gly Gly Ser Arg Val Arg Val Asp Gln Lys 
385                 390                 395                 400 


Cys Lys Ser Ser Val Gln Val Asp Ser Thr Pro Val Ile Ile Thr Ser 
                405                 410                 415     


Asn Thr Asn Met Cys Val Val Val Asp Gly Asn Ser Thr Thr Phe Glu 
            420                 425                 430         


His Gln Gln Pro Leu Glu Asp Arg Met Phe Arg Phe Glu Leu Met Arg 
        435                 440                 445             


Arg Leu Pro Pro Asp Phe Gly Lys Ile Thr Lys Gln Glu Val Lys Asp 
    450                 455                 460                 


Phe Phe Ala Trp Ala Lys Val Asn Gln Val Pro Val Thr His Glu Phe 
465                 470                 475                 480 


Met Val Pro Lys Lys Val Ala Gly Thr Glu Arg Ala Glu Thr Ser Arg 
                485                 490                 495     


Lys Arg Pro Leu Asp Asp Val Thr Asn Thr Asn Tyr Lys Ser Pro Glu 
            500                 505                 510         


Lys Arg Ala Arg Leu Ser Val Val Pro Glu Thr Pro Arg Ser Ser Asp 
        515                 520                 525             


Val Pro Val Glu Pro Ala Pro Leu Arg Pro Leu Asn Trp Ser Ser Arg 
    530                 535                 540                 


Tyr Glu Cys Arg Cys Asp Tyr His Ala Lys Phe Asp Ser Val Thr Gly 
545                 550                 555                 560 


Glu Cys Asp Glu Cys Glu Tyr Leu Asn Arg Gly Lys Asn Gly Cys Ile 
                565                 570                 575     


Phe His Asn Ala Thr His Cys Gln Ile Cys His Ala Val Pro Pro Trp 
            580                 585                 590         


Glu Lys Glu Asn Val Ser Asp Phe Asn Asp Phe Asp Asp Cys Asn Lys 
        595                 600                 605             


Glu Gln 
    610 


<210>  519
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  519

Met Arg Ala Ala Ala Gly Gly Asn Gly Gly Asp Ala Gly Gln Gly Ala 
1               5                   10                  15      


Glu Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
            20                  25                  30          


Ser Glu Ser His Val Thr Thr Thr Ser Thr Arg Thr Trp Val Leu Pro 
        35                  40                  45              


Thr Tyr Asn Asn His Leu Tyr Leu Arg Leu Gly Ser Ser Asn Ala Ser 
    50                  55                  60                  


Asp Thr Phe Asn Gly Phe Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
65                  70                  75                  80  


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
                85                  90                  95      


Asn His Trp Gly Leu Arg Pro Lys Ser Met Gln Val Arg Ile Phe Asn 
            100                 105                 110         


Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu Thr Thr Val Ser 
        115                 120                 125             


Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp Ser Thr Tyr Glu 
    130                 135                 140                 


Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser Leu Pro Pro Phe 
145                 150                 155                 160 


Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Cys Gly Leu Val 
                165                 170                 175     


Thr Gly Gly Ser Ser Gln Asn Gln Thr Asp Arg Asn Ala Phe Tyr Cys 
            180                 185                 190         


Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu 
        195                 200                 205             


Met Val Tyr Lys Phe Glu Asn Val Pro Phe His Ser Met Tyr Ala His 
    210                 215                 220                 


Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Leu Asp Gln Tyr Leu 
225                 230                 235                 240 


Trp Glu Leu Gln Ser Thr Thr Ser Gly Gly Thr Leu Asn Gln Gly Asn 
                245                 250                 255     


Ser Ala Thr Asn Phe Ala Lys Leu Thr Lys Thr Asn Phe Ser Gly Tyr 
            260                 265                 270         


Arg Lys Asn Trp Leu Pro Gly Pro Met Met Lys Gln Gln Arg Phe Ser 
        275                 280                 285             


Lys Thr Ala Ser Gln Asn Tyr Lys Ile Pro Gln Gly Arg Asn Asn Ser 
    290                 295                 300                 


Leu Leu His Tyr Glu Thr Arg Thr Thr Leu Asp Gly Arg Trp Ser Asn 
305                 310                 315                 320 


Phe Ala Pro Gly Thr Ala Met Ala Thr Ala Ala Asn Asp Ala Thr Asp 
                325                 330                 335     


Phe Ser Gln Ala Gln Leu Ile Phe Ala Gly Pro Asn Ile Thr Gly Asn 
            340                 345                 350         


Thr Thr Thr Asp Ala Asn Asn Leu Met Phe Thr Ser Glu Asp Glu Leu 
        355                 360                 365             


Arg Ala Thr Asn Pro Arg Asp Thr Asp Leu Phe Gly His Leu Ala Thr 
    370                 375                 380                 


Asn Gln Gln Asn Ala Thr Thr Val Pro Thr Val Asp Asp Val Asp Gly 
385                 390                 395                 400 


Val Gly Val Tyr Pro Gly Met Val Trp Gln Asp Arg Asp Ile Tyr Tyr 
                405                 410                 415     


Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His 
            420                 425                 430         


Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys Ser Pro Pro Pro Gln 
        435                 440                 445             


Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Ala Thr Thr Phe 
    450                 455                 460                 


Ser Pro Ala Arg Ile Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln 
465                 470                 475                 480 


Val Ala Val Lys Ile Glu Trp Glu Ile Gln Lys Glu Arg Ser Lys Arg 
                485                 490                 495     


Trp Asn Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly Ala Gln Asp Ser 
            500                 505                 510         


Leu Leu Trp Ala Pro Asp Asn Ala Gly Ala Tyr Lys Glu Pro Arg Ala 
        515                 520                 525             


Ile Gly Ser Arg Tyr Leu Thr Asn His Leu 
    530                 535             


<210>  520
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  520

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Ser Ile Gly Asp 
1               5                   10                  15      


Gly Phe Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Ala Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Asp Pro Val 
    50                  55                  60                  


Asn Phe Ala Asp Glu Val Ala Arg Glu His Asp Leu Ser Tyr Gln Lys 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Ser Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Thr Pro Asp Lys Thr Ala Pro Ala Ala Lys Lys Arg 
    130                 135                 140                 


Pro Leu Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Lys Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Asp Asp Glu 
                165                 170                 175     


Pro Gly Ala Gly Asp Gly Pro Pro Pro Glu Gly Pro Ser Ser Gly Ala 
            180                 185                 190         


Met Ser Thr Glu Thr Glu Met Arg Ala Ala Ala Gly Gly Asn Gly Gly 
        195                 200                 205             


Asp Ala Gly Gln Gly Ala Glu Gly Val Gly Asn Ala Ser Gly Asp Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Ser Glu Ser His Val Thr Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Leu Arg Leu 
                245                 250                 255     


Gly Ser Ser Asn Ala Ser Asp Thr Phe Asn Gly Phe Ser Thr Pro Trp 
            260                 265                 270         


Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp 
        275                 280                 285             


Trp Gln Arg Leu Ile Asn Asn His Trp Gly Leu Arg Pro Lys Ser Met 
    290                 295                 300                 


Gln Val Arg Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn 
305                 310                 315                 320 


Gly Glu Thr Thr Val Ser Asn Asn Leu Thr Ser Thr Val His Ile Phe 
                325                 330                 335     


Ala Asp Ser Thr Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu 
            340                 345                 350         


Gly Ser Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr 
        355                 360                 365             


Gly Tyr Cys Gly Leu Val Thr Gly Gly Ser Ser Gln Asn Gln Thr Asp 
    370                 375                 380                 


Arg Asn Ala Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Met Val Tyr Lys Phe Glu Asn Val Pro Phe 
                405                 410                 415     


His Ser Met Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Leu Asp Gln Tyr Leu Trp Glu Leu Gln Ser Thr Thr Ser Gly Gly 
        435                 440                 445             


Thr Leu Asn Gln Gly Asn Ser Ala Thr Asn Phe Ala Lys Leu Thr Asn 
    450                 455                 460                 


Lys Asn Phe Ser Gly Tyr Arg Lys Asn Trp Leu Pro Gly Pro Met Met 
465                 470                 475                 480 


Lys Gln Gln Arg Phe Ser Lys Thr Ala Ser Gln Asn Tyr Lys Ile Pro 
                485                 490                 495     


Gln Gly Gly Asn Asn Ser Leu Leu His Tyr Glu Thr Arg Thr Thr Leu 
            500                 505                 510         


Asp Arg Arg Trp Ser Asn Phe Ala Pro Gly Thr Ala Met Ala Thr Ala 
        515                 520                 525             


Ala Asn Asp Ala Thr Asp Phe Ser Gln Ala Gln Leu Ile Phe Ala Gly 
    530                 535                 540                 


Pro Asn Ile Thr Gly Asn Thr Thr Thr Asp Ala Asn Asn Leu Met Phe 
545                 550                 555                 560 


Thr Ser Glu Asp Glu Leu Arg Ala Thr Asn Pro Arg Asp Thr Asp Leu 
                565                 570                 575     


Phe Gly His Leu Ala Thr Asn Gln Gln Asn Ala Thr Thr Val Pro Thr 
            580                 585                 590         


Val Asp Asp Val Asp Gly Val Gly Val Tyr Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Ser Pro Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Ala Thr Thr Phe Ser Pro Ala Arg Ile Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ala Val Lys Ile Glu Trp Glu Ile Gln 
        675                 680                 685             


Lys Glu Arg Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn 
    690                 695                 700                 


Tyr Gly Ala Gln Asp Ser Leu Leu Trp Ala Pro Asp Asn Ala Gly Ala 
705                 710                 715                 720 


Tyr Lys Glu Pro Arg Ala Ile Gly Ser Arg Tyr Leu Thr Asn His Leu 
                725                 730                 735     


<210>  521
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  521

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Ser Ile Gly Asp 
1               5                   10                  15      


Gly Phe Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Ala Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Asp Pro Val 
    50                  55                  60                  


Asn Phe Ala Asp Glu Val Ala Arg Glu His Asp Leu Ser Tyr Gln Lys 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Ser Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Thr Pro Asp Lys Thr Ala Pro Ala Ala Lys Lys Arg 
    130                 135                 140                 


Pro Leu Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Lys Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Asp Asp Glu 
                165                 170                 175     


Pro Gly Ala Gly Asp Gly Pro Pro Pro Glu Gly Pro Ser Ser Gly Ala 
            180                 185                 190         


Met Ser Thr Glu Thr Glu Met Arg Ala Ala Ala Gly Gly Asn Gly Gly 
        195                 200                 205             


Asp Ala Gly Gln Gly Ala Glu Gly Val Gly Asn Ala Ser Gly Asp Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Ser Glu Ser His Val Thr Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Leu Arg Leu 
                245                 250                 255     


Gly Ser Ser Asn Ala Ser Asp Thr Phe Asn Gly Phe Ser Thr Pro Trp 
            260                 265                 270         


Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp 
        275                 280                 285             


Trp Gln Arg Leu Ile Asn Asn His Trp Gly Leu Arg Pro Lys Ser Met 
    290                 295                 300                 


Gln Val Arg Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn 
305                 310                 315                 320 


Gly Glu Thr Thr Val Ser Asn Asn Leu Thr Ser Thr Val Gln Ile Phe 
                325                 330                 335     


Ala Asp Ser Thr Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu 
            340                 345                 350         


Gly Ser Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr 
        355                 360                 365             


Gly Tyr Cys Gly Leu Val Thr Gly Gly Ser Ser Gln Asn Gln Thr Asp 
    370                 375                 380                 


Arg Asn Ala Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Met Val Tyr Lys Phe Glu Asn Val Pro Phe 
                405                 410                 415     


His Ser Met Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Leu Asp Gln Tyr Leu Trp Glu Leu Gln Ser Thr Thr Ser Gly Gly 
        435                 440                 445             


Thr Leu Asn Gln Gly Asn Ser Ala Thr Asn Phe Ala Lys Leu Thr Lys 
    450                 455                 460                 


Thr Asn Phe Ser Gly Tyr Arg Lys Asn Trp Leu Pro Gly Pro Met Met 
465                 470                 475                 480 


Lys Gln Gln Arg Phe Ser Lys Thr Ala Ser Gln Asn Tyr Lys Ile Pro 
                485                 490                 495     


Gln Gly Arg Asn Asn Ser Leu Leu His Tyr Glu Thr Arg Thr Thr Leu 
            500                 505                 510         


Asp Gly Arg Trp Ser Asn Phe Ala Pro Gly Thr Ala Met Ala Thr Ala 
        515                 520                 525             


Ala Asn Asp Ala Thr Asp Phe Ser Gln Ala Gln Leu Ile Phe Ala Gly 
    530                 535                 540                 


Pro Asn Ile Thr Gly Asn Thr Thr Thr Asp Ala Asn Asn Leu Met Phe 
545                 550                 555                 560 


Thr Ser Glu Asp Glu Leu Arg Ala Thr Asn Pro Arg Asp Thr Asp Leu 
                565                 570                 575     


Phe Gly His Leu Ala Thr Asn Gln Gln Asn Ala Thr Thr Val Pro Thr 
            580                 585                 590         


Val Asp Asp Val Asp Gly Val Gly Val Tyr Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Ser Pro Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Ala Thr Thr Phe Ser Pro Ala Arg Ile Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ala Val Lys Ile Glu Trp Glu Ile Gln 
        675                 680                 685             


Lys Glu Arg Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn 
    690                 695                 700                 


Tyr Gly Ala Gln Asp Ser Leu Leu Trp Ala Pro Asp Asn Ala Gly Ala 
705                 710                 715                 720 


Tyr Lys Glu Pro Arg Ala Ile Gly Ser Arg Tyr Leu Thr Asn His Leu 
                725                 730                 735     


<210>  522
<211>  736
<212>  PRT
<213>  Bovine adeno-associated virus

<400>  522

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Ser Ile Gly Asp 
1               5                   10                  15      


Gly Phe Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Ala Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Asp Pro Val 
    50                  55                  60                  


Asn Phe Ala Asp Glu Val Ala Arg Glu His Asp Leu Ser Tyr Gln Lys 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Ser Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Thr Pro Asp Lys Thr Ala Pro Ala Ala Lys Lys Arg 
    130                 135                 140                 


Pro Leu Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Lys Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Asp Asp Glu 
                165                 170                 175     


Pro Gly Ala Gly Asp Gly Pro Pro Pro Glu Gly Pro Ser Ser Gly Ala 
            180                 185                 190         


Met Ser Thr Glu Thr Glu Met Arg Ala Ala Ala Gly Gly Asn Gly Gly 
        195                 200                 205             


Asp Ala Gly Gln Gly Ala Glu Gly Val Gly Asn Ala Ser Gly Asp Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Ser Glu Ser His Val Thr Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Leu Arg Leu 
                245                 250                 255     


Gly Ser Ser Asn Ala Ser Asp Thr Phe Asn Gly Phe Ser Thr Pro Trp 
            260                 265                 270         


Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp 
        275                 280                 285             


Trp Gln Arg Leu Ile Asn Asn His Trp Gly Leu Arg Pro Lys Ser Met 
    290                 295                 300                 


Gln Val Arg Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn 
305                 310                 315                 320 


Gly Glu Thr Thr Val Ser Asn Asn Leu Thr Ser Thr Val Gln Ile Phe 
                325                 330                 335     


Ala Asp Ser Thr Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu 
            340                 345                 350         


Gly Ser Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr 
        355                 360                 365             


Gly Tyr Cys Gly Leu Val Thr Gly Gly Ser Ser Gln Asn Gln Thr Asp 
    370                 375                 380                 


Arg Asn Ala Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Met Val Tyr Lys Phe Glu Asn Val Pro Phe 
                405                 410                 415     


His Ser Met Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Leu Asp Gln Tyr Leu Trp Glu Leu Gln Ser Thr Thr Ser Gly Gly 
        435                 440                 445             


Thr Leu Asn Gln Gly Asn Ser Ala Thr Asn Phe Ala Lys Leu Thr Lys 
    450                 455                 460                 


Thr Asn Phe Ser Gly Tyr Arg Lys Asn Trp Leu Pro Gly Pro Met Met 
465                 470                 475                 480 


Lys Gln Gln Arg Phe Ser Lys Thr Ala Ser Gln Asn Tyr Lys Ile Pro 
                485                 490                 495     


Gln Gly Arg Asn Asn Ser Leu Leu His Tyr Glu Thr Arg Thr Thr Leu 
            500                 505                 510         


Asp Gly Arg Trp Ser Asn Phe Ala Pro Gly Thr Ala Met Ala Thr Ala 
        515                 520                 525             


Ala Asn Asp Ala Thr Asp Phe Ser Gln Ala Gln Leu Ile Phe Ala Gly 
    530                 535                 540                 


Pro Asn Ile Thr Gly Asn Thr Thr Thr Asp Ala Asn Asn Leu Met Phe 
545                 550                 555                 560 


Thr Ser Glu Asp Glu Leu Arg Ala Thr Asn Pro Arg Asp Thr Asp Leu 
                565                 570                 575     


Phe Gly His Leu Ala Thr Asn Gln Gln Asn Ala Thr Thr Val Pro Thr 
            580                 585                 590         


Val Asp Asp Val Asp Gly Val Gly Val Tyr Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Ser Pro Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Ala Thr Thr Phe Ser Pro Ala Arg Ile Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ala Val Lys Ile Glu Trp Glu Ile Gln 
        675                 680                 685             


Lys Glu Arg Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn 
    690                 695                 700                 


Tyr Gly Ala Gln Asp Ser Leu Leu Trp Ala Pro Asp Asn Ala Gly Ala 
705                 710                 715                 720 


Tyr Lys Glu Pro Arg Ala Ile Gly Ser Arg Tyr Leu Thr Asn His Leu 
                725                 730                 735     


<210>  523
<211>  600
<212>  PRT
<213>  Bovine adeno-associated virus

<400>  523

Thr Ala Pro Ala Ala Lys Lys Arg Pro Leu Glu Gln Ser Pro Gln Glu 
1               5                   10                  15      


Pro Asp Ser Ser Ser Gly Val Gly Lys Lys Gly Lys Gln Pro Ala Arg 
            20                  25                  30          


Lys Arg Leu Asn Phe Asp Asp Glu Pro Gly Ala Gly Asp Gly Pro Pro 
        35                  40                  45              


Pro Glu Gly Pro Ser Ser Gly Ala Met Ser Thr Glu Thr Glu Met Arg 
    50                  55                  60                  


Ala Ala Ala Gly Gly Asn Gly Gly Asp Ala Gly Gln Gly Ala Glu Gly 
65                  70                  75                  80  


Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp Ser Glu 
                85                  90                  95      


Ser His Val Thr Thr Thr Ser Thr Arg Thr Trp Val Leu Pro Thr Tyr 
            100                 105                 110         


Asn Asn His Leu Tyr Leu Arg Leu Gly Ser Ser Asn Ala Ser Asp Thr 
        115                 120                 125             


Phe Asn Gly Phe Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
    130                 135                 140                 


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn His 
145                 150                 155                 160 


Trp Gly Leu Arg Pro Lys Ser Met Gln Val Arg Ile Phe Asn Ile Gln 
                165                 170                 175     


Val Lys Glu Val Thr Thr Ser Asn Gly Glu Thr Thr Val Ser Asn Asn 
            180                 185                 190         


Leu Thr Ser Thr Val Gln Ile Phe Ala Asp Ser Thr Tyr Glu Leu Pro 
        195                 200                 205             


Tyr Val Met Asp Ala Gly Gln Glu Gly Ser Leu Pro Pro Phe Pro Asn 
    210                 215                 220                 


Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Cys Gly Leu Val Thr Gly 
225                 230                 235                 240 


Gly Ser Ser Gln Asn Gln Thr Asp Arg Asn Ala Phe Tyr Cys Leu Glu 
                245                 250                 255     


Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Met Val 
            260                 265                 270         


Tyr Lys Phe Glu Asn Val Pro Phe His Ser Met Tyr Ala His Ser Gln 
        275                 280                 285             


Ser Leu Asp Arg Leu Met Asn Pro Leu Leu Asp Gln Tyr Leu Trp Glu 
    290                 295                 300                 


Leu Gln Ser Thr Thr Ser Gly Gly Thr Leu Asn Gln Gly Asn Ser Ala 
305                 310                 315                 320 


Thr Asn Phe Ala Lys Leu Thr Lys Thr Asn Phe Ser Gly Tyr Arg Lys 
                325                 330                 335     


Asn Trp Leu Pro Gly Pro Met Met Lys Gln Gln Arg Phe Ser Lys Thr 
            340                 345                 350         


Ala Ser Gln Asn Tyr Lys Ile Pro Gln Gly Arg Asn Asn Ser Leu Leu 
        355                 360                 365             


His Tyr Glu Thr Arg Thr Thr Leu Asp Gly Arg Trp Ser Asn Phe Ala 
    370                 375                 380                 


Pro Gly Thr Ala Met Ala Thr Ala Ala Asn Asp Ala Thr Asp Phe Ser 
385                 390                 395                 400 


Gln Ala Gln Leu Ile Phe Ala Gly Pro Asn Ile Thr Gly Asn Thr Thr 
                405                 410                 415     


Thr Asp Ala Asn Asn Leu Met Phe Thr Ser Glu Asp Glu Leu Arg Ala 
            420                 425                 430         


Thr Asn Pro Arg Asp Thr Asp Leu Phe Gly His Leu Ala Thr Asn Gln 
        435                 440                 445             


Gln Asn Ala Thr Thr Val Pro Thr Val Asp Asp Val Asp Gly Val Gly 
    450                 455                 460                 


Val Tyr Pro Gly Met Val Trp Gln Asp Arg Asp Ile Tyr Tyr Gln Gly 
465                 470                 475                 480 


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser 
                485                 490                 495     


Pro Leu Ile Gly Gly Phe Gly Leu Lys Ser Pro Pro Pro Gln Ile Phe 
            500                 505                 510         


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Ala Thr Thr Phe Ser Pro 
        515                 520                 525             


Ala Arg Ile Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ala 
    530                 535                 540                 


Val Lys Ile Glu Trp Glu Ile Gln Lys Glu Arg Ser Lys Arg Trp Asn 
545                 550                 555                 560 


Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly Ala Gln Asp Ser Leu Leu 
                565                 570                 575     


Trp Ala Pro Asp Asn Ala Gly Ala Tyr Lys Glu Pro Arg Ala Ile Gly 
            580                 585                 590         


Ser Arg Tyr Leu Thr Asn His Leu 
        595                 600 


<210>  524
<211>  2214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  524
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacggga catcgggagg agccaccaac gacaacacct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagagactca gcttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcggagtac cagctgccgt acgttctcgg ctctgcccac     1080

cagggctgcc tgcctccgtt cccggcggac gtgttcatga ttccccagta cggctaccta     1140

acactcaaca acggtagtca ggccgtggga cgctcctcct tctactgcct ggaatacttt     1200

ccttcgcaga tgctgagaac cggcaacaac ttccagttta cttacacctt cgaggacgtg     1260

cctttccaca gcagctacgc ccacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacggc aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca acaacgcgtc tcaacgacaa ccgggcaaaa caacaatagc     1500

aactttgcct ggactgctgg gaccaaatac catctgaatg gaagaaattc attggctaat     1560

cctggcatcg ctatggcaac acacaaagac gacaaggagc gtttttttcc cagtaacggg     1620

atcctgattt ttggcaaaca aaatgctgcc agagacaatg cggattacag cgatgtcatg     1680

ctcaccagcg aggaagaaat caaaaccact aaccctgtgg ctacagagga atacggtatc     1740

gtggcagata acttgcagca gcaaaacacg gctcctcaaa ttggaactgt caacagccag     1800

ggggccttac ccggtatggt ttggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttc cacccgtctc cgctgatggg cggctttggc     1920

ctgaaacatc ctccgcctca gatcctgatc aagaacacgc ctgtacctgc ggatcctccg     1980

accaccttca accagtcaaa gctgaactct ttcatcacgc aatacagcac cggacaggtc     2040

agcgtggaaa ttgaatggga gctgcagaag gaaaacagca agcgctggaa ccccgagatc     2100

cagtacacct ccaactacta caaatctaca agtgtggact ttgctgttaa tacagaaggc     2160

gtgtactctg aaccccaccc cattggcacc cgttacctca cccgtcccct gtaa           2214


<210>  525
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  525

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr His 
        515                 520                 525             


Lys Asp Asp Lys Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met 
545                 550                 555                 560 


Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro 
            580                 585                 590         


Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro His Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 735     


Leu 
    


<210>  526
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  526

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg 
        435                 440                 445             


Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe Ser 
    450                 455                 460                 


Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr His Lys 
        515                 520                 525             


Asp Asp Lys Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met Leu 
545                 550                 555                 560 


Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro Gln 
            580                 585                 590         


Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro His Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  527
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  527

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Gly Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Glu Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg 
        435                 440                 445             


Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe Ser 
    450                 455                 460                 


Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr His Lys 
        515                 520                 525             


Asp Asp Lys Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met Leu 
545                 550                 555                 560 


Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro Gln 
            580                 585                 590         


Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro His Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  528
<211>  2181
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  528
atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag       60

tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa      120

gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga      180

ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag      240

cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag      300

gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc      360

aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc      420

ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc      480

aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc      540

ccagcacaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca      600

ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc      660

gattccacgt ggatggggga cagagtcgtc accaagtcca cccgcacctg ggtgctgccc      720

agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc      780

aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc      840

cactggagcc cccgagactg gcaaagactc atcaacaact attggggctt cagaccccgg      900

tctctcagag tcaaaatctt caacatccaa gtcaaagagg tcacggtgca ggactccacc      960

accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccaa     1020

ctcccgtacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc cccgcaggtc     1080

tttacgctgc cgcagtacgg ctacgcgacg ctgaaccgag acaacggaga caacccgaca     1140

gagcggagca gcttcttttg cctagagtac tttcccagca agatgctgag gacgggcaac     1200

aactttgagt ttacctacag ctttgaagag gtgcccttcc actgcagctt cgccccgagc     1260

cagaacctct ttaagctggc caacccgctg gtggaccagt acctgtaccg cttcgtgagc     1320

acctcggcca cgggcgccat ccagttccaa aagaacctgg cgggcagata cgccaacacc     1380

tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacac gagctctggg     1440

gtcagcagca ccaacagagt cagcgtcaac aacttttccg tctcaaaccg gatgaacctg     1500

gagggggcca gctaccaagt gaacccccag cccaacggga tgacaaacac gctccaaggc     1560

agcaaccgct acgcgctgga aaacaccatg atcttcaacg ctcaaaacgc cacgccggga     1620

actacctcgg tgtacccaga ggacaatcta ctgctgacca gcgagagcga gactcagccc     1680

gtcaaccggg tggcttacaa cacgggcggt cagatggcca ccaacgccca gaacgccacc     1740

acggctccca cggtcgggac ctacaacctc caggaagtgc ttcctggcag cgtatggatg     1800

gagagggacg tgtacctcca aggacccatc tgggccaaga tcccagagac gggggcgcac     1860

tttcacccct ctccggccat gggcggattc ggactcaaac acccgccgcc catgatgctc     1920

atcaaaaaca cgccggtgcc cggcaacatc accagcttct cggacgtgcc cgtcagcagc     1980

ttcatcaccc agtacagcac cgggcaggtc accgtggaga tggaatggga gctcaaaaag     2040

gaaaactcca agaggtggaa cccagagatc cagtacacca acaactacaa cgacccccag     2100

tttgtggact ttgctccaga cggctccggc gaatacagaa ccaccagagc catcggaacc     2160

cgatacctca cccgacccct t                                               2181


<210>  529
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  529

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 
225                 230                 235                 240 


Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 
                245                 250                 255     


Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 
305                 310                 315                 320 


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
                325                 330                 335     


Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 
            340                 345                 350         


Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Ala Thr Leu Asn Arg Asp Asn Gly Asp Asn Pro Thr Glu Arg Ser Ser 
    370                 375                 380                 


Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Phe Thr Tyr Ser Phe Glu Glu Val Pro Phe His Cys Ser 
                405                 410                 415     


Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Arg Phe Val Ser Thr Ser Ala Thr Gly Ala Ile Gln 
        435                 440                 445             


Phe Gln Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 
    450                 455                 460                 


Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Thr Ser Ser Gly 
465                 470                 475                 480 


Ser Ser Thr Asn Arg Val Ser Val Asn Asn Phe Ser Val Ser Asn Arg 
                485                 490                 495     


Met Asn Leu Glu Gly Ala Ser Tyr Gln Val Asn Pro Gln Pro Asn Gly 
            500                 505                 510         


Met Thr Asn Thr Leu Gln Gly Ser Asn Arg Tyr Ala Leu Glu Asn Thr 
        515                 520                 525             


Met Ile Phe Asn Ala Gln Asn Ala Thr Pro Gly Thr Thr Ser Val Tyr 
    530                 535                 540                 


Pro Glu Asp Asn Leu Leu Leu Thr Ser Glu Ser Glu Thr Gln Pro Val 
545                 550                 555                 560 


Asn Arg Val Ala Tyr Asn Thr Gly Gly Gln Met Ala Thr Asn Ala Gln 
                565                 570                 575     


Asn Ala Thr Thr Ala Pro Thr Val Gly Thr Tyr Asn Leu Gln Glu Val 
            580                 585                 590         


Leu Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 
        595                 600                 605             


Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 
    610                 615                 620                 


Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 
625                 630                 635                 640 


Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 
                645                 650                 655     


Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 
            660                 665                 670         


Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 
        675                 680                 685             


Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 
    690                 695                 700                 


Pro Asp Gly Ser Gly Glu Tyr Arg Thr Thr Arg Ala Ile Gly Thr Arg 
705                 710                 715                 720 


Tyr Leu Thr Arg Pro Leu 
                725     


<210>  530
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  530

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ser Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  531
<211>  1797
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  531
acggctccga ccggagacaa gcggaaaggc gaagacgaac ctcgtttgcc cgacacttct       60

tcacagactc ccaagaaaaa caagaagcct cgcaaggaaa gaccttccgg cggggcagaa      120

gatccgggcg aaggcacctc ttccaacgct ggagcagcag cacccgcctc tagtgtggga      180

tcatctatca tggctgaagg aggtggcggc ccagtgggcg atgcaggcca gggtgccgat      240

ggagtgggca attcctccgg aaattggcat tgcgattccc aatggctgga aaacggagtc      300

gtcactcgaa ccacccgaac ctgggtcttg cccagctaca acaaccacct gtacaaacga      360

atccaaggac ccagcggagg cgacaacaac aacaaattct ttggattcag caccccctgg      420

ggatactttg actacaatcg attccactgc cacttttccc cgcgagactg gcaacgactc      480

atcaacaaca actggggcat ccgtcccaaa gcgatgcgct ttagactctt taacatccag      540

gttaaagagg tcacggtcca agacttcaac accaccatcg gcaacaacct caccagtacg      600

gtccaggtct ttgcggacaa ggactaccaa ctgccgtacg tcctcggatc ggctaccgaa      660

ggcaccttcc cgccgttccc agcggatatc tacacgatcc cgcagtacgg gtactgcacg      720

ctaaactaca acaacgaggc ggtggatcgt tcggccttct actgtctgga ctactttccc      780

tcagacatgc tgcggacagg aaataacttt gagtttactt acaccttcga ggacgttcct      840

ttccatagca tgtttgccca caaccagacg ctagaccggc tgatgaatcc cctcgtggat      900

cagtacctct gggctttcag ctccgtcagc caagcaggct catctggacg agctcttcat      960

tactcgcggg cgactaaaac caacatggcg gctcaatata ggaactggtt acctgggcct     1020

ttcttccgtg atcagcaaat ctttacgggc gctagcaaca tcactaaaaa taacgtcttt     1080

agcgtttggg aaaaaggcaa gcaatgggaa ctcgacaatc ggaccaacct aatgcagccc     1140

ggtcctgcgg cagcgaccac ctttagcgga gaacctgacc gtcaagccat gcaaaacacg     1200

ctggctttta gcaggaccgt ctacgatcaa acgaccgcca cgaccgatcg taaccagata     1260

ctcatcacca acgaagacga aatcagaccc accaactcgg tcggtatcga cgcgtgggga     1320

gcagttccca ccaacaacca gtcgatcgtg acccccggca ctcgcgcggc cgtcaacaat     1380

caaggggcgc ttcccgggat ggtgtggcaa aacagagaca tttaccctac agggacccat     1440

ttggccaaaa ttcccgacac tgacaatcac ttccatccgt ccccgcttat tgggcggttt     1500

ggctgcaagc atccccctcc ccagattttc attaaaaaca cacccgtccc tgccaaccct     1560

tcggaaacgt tccagacggc caaagtggcc tccttcatca accagtactc gaccggacag     1620

tgcaccgtcg aaatcttttg ggaactcaag aaggaaacct ccaagcgctg gaaccccgaa     1680

atccagttca cctccaactt tggcaacgcg gccgacatcc agtttgccgt ctccgacacg     1740

ggatcctatt ccgaacctcg tcccatcggt acccgttacc ttaccaaacc tctgtaa        1797


<210>  532
<211>  1989
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  532
atgaggtcgt actacgaggt catcgttcag ctgcccaacg acgtcgagag tcaggtacct       60

ggaatctccg attcgttcgt caactggatt acgtcgcgag aatggacgtt gcctgaggac      120

gccgattggg atttggacca ggtcgatcaa gttcaactga cgctcggcga caaaatccaa      180

cgggagattc gaactcattg ggggacgatg gccaaagaac cggactttca ctattttatc      240

caactggaac aaggtgaggt gttctttcat ttacacgtcc tgctggaaac gtgttccgta      300

aagccgatgg tactcggaag atatatccga catattcaac aaaaaattgt gagtaaagtc      360

tactgcgcca cgagcctacg atggaaggat ggatgcgtgg tgaccaagac caaaaatttc      420

gggggcgcga acaaggtccg ggccgagtcg tatattcccg cctacctgat cccgaaacag      480

caaccggaag tgcagtgggc gtggactaac gtgcccgagt atataaaagc gtgcttgcac      540

cgagaactgc gtgccagtct cgcgcgactt cacttcgagg aggcgggcgt ctcgcaatcc      600

aaggaaaatc tcgcgagaac tgcagacggc gctcccgtga tgccgacccg cgtcagcaaa      660

cgctacatgg agctcgtgga ttggctcgtg gagaagggga tcaccaccga gaaggaatgg      720

ctgctggaaa acagagaaag ctttcggagc tttcaggcct cgagcaactc ggcgcgtcag      780

atcaagacgg ccctgcaagg cgccattcag gagatgcttc tgaccaagac ggcggaggac      840

tacctcgtcg gaaaggatcc cgtctcggac gacgacatcc gtcagaaccg catctacaag      900

attctggaac tgaaccacta cgacccagcg tacgtgggga gtattttggt cgggtggtgc      960

cagaagaaat ggggcaagcg aaacacgctg tggctgttcg gacatgcgac caccggcaag     1020

accaacatcg cggaggctat tgcccatgct gtgccgttct atggatgcgt taactggacc     1080

aacgagaact ttccgttcaa cgactgcgtc gaaaaaatga ttatctggtg ggaggagggc     1140

aaaatgaccg ccaaagtggt ggaaacagcc aaggcgattc tgggaggatc tcgggtgaga     1200

gtggaccaaa aatgcaaagc ttcggttccg atcgaaccga cgccggtcat tattaccagt     1260

aacaccaaca tgtgttatgt catcgacggg aacacgacca cgttcgagca taagcagccg     1320

ttggaggaca ggatgtttaa gctcgaattg ctgactcggt tgcctgatga ctttggtaag     1380

gtgaccaaac aggaggtgcg tcaattcttc aggtggtctc aggatcacct gacccctgtg     1440

atcccagaat tcctagtgcg gaaggcggag tctcgcaaaa gacccgcccc ttccggggaa     1500

ggctatataa gcccgacaaa gcggcccgcg ctcgcagagc agcagcaggc gtcggagagc     1560

gcggacccgg ttcccaccag gtatcgtatc aaatgctcga aacattgcgg tatggataaa     1620

atgttgtttc cttgccaaat ttgtgaatcg atgaacagag atattaatat ttgtgctatt     1680

cataaaacga ccgactgtaa agagtgtttc cccgactacg gggataaaga tgatgtagaa     1740

ctacccccct gtacagaaca caacgtgtct cgttgttatc aatgtcattc gggcgaattg     1800

tatcgcgtga cttcggactc tgacgagaaa cctgcccccg agagtgatga aggcaccgag     1860

ccatcctatg ctccctgcac gattcaccac ctgatgggca agagtcacgg gttagtcact     1920

tgcgcggcgt gtcggttgaa aaatagtacg ttgcatgatg acttggatga cggtgatctc     1980

gaacaataa                                                             1989


<210>  533
<211>  1626
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  533
atgaggtcgt actacgaggt catcgttcag ctgcccaacg acgtcgagag tcaggtacct       60

ggaatctccg attcgttcgt caactggatt acgtcgcgag aatggacgtt gcctgaggac      120

gccgattggg atttggacca ggtcgatcaa gttcaactga cgctcggcga caaaatccaa      180

cgggagattc gaactcattg ggggacgatg gccaaagaac cggactttca ctattttatc      240

caactggaac aaggtgaggt gttctttcat ttacacgtcc tgctggaaac gtgttccgta      300

aagccgatgg tactcggaag atatatccga catattcaac aaaaaattgt gagtaaagtc      360

tactgcgcca cgagcctacg atggaaggat ggatgcgtgg tgaccaagac caaaaatttc      420

gggggcgcga acaaggtccg ggccgagtcg tatattcccg cctacctgat cccgaaacag      480

caaccggaag tgcagtgggc gtggactaac gtgcccgagt atataaaagc gtgcttgcac      540

cgagaactgc gtgccagtct cgcgcgactt cacttcgagg aggcgggcgt ctcgcaatcc      600

aaggaaaatc tcgcgagaac tgcagacggc gctcccgtga tgccgacccg cgtcagcaaa      660

cgctacatgg agctcgtgga ttggctcgtg gagaagggga tcaccaccga gaaggaatgg      720

ctgctggaaa acagagaaag ctttcggagc tttcaggcct cgagcaactc ggcgcgtcag      780

atcaagacgg ccctgcaagg cgccattcag gagatgcttc tgaccaagac ggcggaggac      840

tacctcgtcg gaaaggatcc cgtctcggac gacgacatcc gtcagaaccg catctacaag      900

attctggaac tgaaccacta cgacccagcg tacgtgggga gtattttggt cgggtggtgc      960

cagaagaaat ggggcaagcg aaacacgctg tggctgttcg gacatgcgac caccggcaag     1020

accaacatcg cggaggctat tgcccatgct gtgccgttct atggatgcgt taactggacc     1080

aacgagaact ttccgttcaa cgactgcgtc gaaaaaatga ttatctggtg ggaggagggc     1140

aaaatgaccg ccaaagtggt ggaaacagcc aaggcgattc tgggaggatc tcgggtgaga     1200

gtggaccaaa aatgcaaagc ttcggttccg atcgaaccga cgccggtcat tattaccagt     1260

aacaccaaca tgtgttatgt catcgacggg aacacgacca cgttcgagca taagcagccg     1320

ttggaggaca ggatgtttaa gctcgaattg ctgactcggt tgcctgatga ctttggtaag     1380

gtgaccaaac aggaggtgcg tcaattcttc aggtggtctc aggatcacct gacccctgtg     1440

atcccagaat tcctagtgcg gaaggcggag tctcgcaaaa gacccgcccc ttccggggaa     1500

ggctatataa gcccgacaaa gcggcccgcg ctcgcagagc agcagcaggc gtcggagagc     1560

gcggacccgg ttcccaccag attggttgga gcggttggtc aaaaagggag tgaatgctgc     1620

agctga                                                                1626


<210>  534
<211>  1323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  534
atggagctcg tggattggct cgtggagaag gggatcacca ccgagaagga atggctgctg       60

gaaaacagag aaagctttcg gagctttcag gcctcgagca actcggcgcg tcagatcaag      120

acggccctgc aaggcgccat tcaggagatg cttctgacca agacggcgga ggactacctc      180

gtcggaaagg atcccgtctc ggacgacgac atccgtcaga accgcatcta caagattctg      240

gaactgaacc actacgaccc agcgtacgtg gggagtattt tggtcgggtg gtgccagaag      300

aaatggggca agcgaaacac gctgtggctg ttcggacatg cgaccaccgg caagaccaac      360

atcgcggagg ctattgccca tgctgtgccg ttctatggat gcgttaactg gaccaacgag      420

aactttccgt tcaacgactg cgtcgaaaaa atgattatct ggtgggagga gggcaaaatg      480

accgccaaag tggtggaaac agccaaggcg attctgggag gatctcgggt gagagtggac      540

caaaaatgca aagcttcggt tccgatcgaa ccgacgccgg tcattattac cagtaacacc      600

aacatgtgtt atgtcatcga cgggaacacg accacgttcg agcataagca gccgttggag      660

gacaggatgt ttaagctcga attgctgact cggttgcctg atgactttgg taaggtgacc      720

aaacaggagg tgcgtcaatt cttcaggtgg tctcaggatc acctgacccc tgtgatccca      780

gaattcctag tgcggaaggc ggagtctcgc aaaagacccg ccccttccgg ggaaggctat      840

ataagcccga caaagcggcc cgcgctcgca gagcagcagc aggcgtcgga gagcgcggac      900

ccggttccca ccaggtatcg tatcaaatgc tcgaaacatt gcggtatgga taaaatgttg      960

tttccttgcc aaatttgtga atcgatgaac agagatatta atatttgtgc tattcataaa     1020

acgaccgact gtaaagagtg tttccccgac tacggggata aagatgatgt agaactaccc     1080

ccctgtacag aacacaacgt gtctcgttgt tatcaatgtc attcgggcga attgtatcgc     1140

gtgacttcgg actctgacga gaaacctgcc cccgagagtg atgaaggcac cgagccatcc     1200

tatgctccct gcacgattca ccacctgatg ggcaagagtc acgggttagt cacttgcgcg     1260

gcgtgtcggt tgaaaaatag tacgttgcat gatgacttgg atgacggtga tctcgaacaa     1320

taa                                                                   1323


<210>  535
<211>  960
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  535
atggagctcg tggattggct cgtggagaag gggatcacca ccgagaagga atggctgctg       60

gaaaacagag aaagctttcg gagctttcag gcctcgagca actcggcgcg tcagatcaag      120

acggccctgc aaggcgccat tcaggagatg cttctgacca agacggcgga ggactacctc      180

gtcggaaagg atcccgtctc ggacgacgac atccgtcaga accgcatcta caagattctg      240

gaactgaacc actacgaccc agcgtacgtg gggagtattt tggtcgggtg gtgccagaag      300

aaatggggca agcgaaacac gctgtggctg ttcggacatg cgaccaccgg caagaccaac      360

atcgcggagg ctattgccca tgctgtgccg ttctatggat gcgttaactg gaccaacgag      420

aactttccgt tcaacgactg cgtcgaaaaa atgattatct ggtgggagga gggcaaaatg      480

accgccaaag tggtggaaac agccaaggcg attctgggag gatctcgggt gagagtggac      540

caaaaatgca aagcttcggt tccgatcgaa ccgacgccgg tcattattac cagtaacacc      600

aacatgtgtt atgtcatcga cgggaacacg accacgttcg agcataagca gccgttggag      660

gacaggatgt ttaagctcga attgctgact cggttgcctg atgactttgg taaggtgacc      720

aaacaggagg tgcgtcaatt cttcaggtgg tctcaggatc acctgacccc tgtgatccca      780

gaattcctag tgcggaaggc ggagtctcgc aaaagacccg ccccttccgg ggaaggctat      840

ataagcccga caaagcggcc cgcgctcgca gagcagcagc aggcgtcgga gagcgcggac      900

ccggttccca ccagattggt tggagcggtt ggtcaaaaag ggagtgaatg ctgcagctga      960


<210>  536
<211>  1608
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  536
atggctgaag gaggtggcgg cccagtgggc gatgcaggcc agggtgccga tggagtgggc       60

aattcctccg gaaattggca ttgcgattcc caatggctgg aaaacggagt cgtcactcga      120

accacccgaa cctgggtctt gcccagctac aacaaccacc tgtacaaacg aatccaagga      180

cccagcggag gcgacaacaa caacaaattc tttggattca gcaccccctg gggatacttt      240

gactacaatc gattccactg ccacttttcc ccgcgagact ggcaacgact catcaacaac      300

aactggggca tccgtcccaa agcgatgcgc tttagactct ttaacatcca ggttaaagag      360

gtcacggtcc aagacttcaa caccaccatc ggcaacaacc tcaccagtac ggtccaggtc      420

tttgcggaca aggactacca actgccgtac gtcctcggat cggctaccga aggcaccttc      480

ccgccgttcc cagcggatat ctacacgatc ccgcagtacg ggtactgcac gctaaactac      540

aacaacgagg cggtggatcg ttcggccttc tactgtctgg actactttcc ctcagacatg      600

ctgcggacag gaaataactt tgagtttact tacaccttcg aggacgttcc tttccatagc      660

atgtttgccc acaaccagac gctagaccgg ctgatgaatc ccctcgtgga tcagtacctc      720

tgggctttca gctccgtcag ccaagcaggc tcatctggac gagctcttca ttactcgcgg      780

gcgactaaaa ccaacatggc ggctcaatat aggaactggt tacctgggcc tttcttccgt      840

gatcagcaaa tctttacggg cgctagcaac atcactaaaa ataacgtctt tagcgtttgg      900

gaaaaaggca agcaatggga actcgacaat cggaccaacc taatgcagcc cggtcctgcg      960

gcagcgacca cctttagcgg agaacctgac cgtcaagcca tgcaaaacac gctggctttt     1020

agcaggaccg tctacgatca aacgaccgcc acgaccgatc gtaaccagat actcatcacc     1080

aacgaagacg aaatcagacc caccaactcg gtcggtatcg acgcgtgggg agcagttccc     1140

accaacaacc agtcgatcgt gacccccggc actcgcgcgg ccgtcaacaa tcaaggggcg     1200

cttcccggga tggtgtggca aaacagagac atttacccta cagggaccca tttggccaaa     1260

attcccgaca ctgacaatca cttccatccg tccccgctta ttgggcggtt tggctgcaag     1320

catccccctc cccagatttt cattaaaaac acacccgtcc ctgccaaccc ttcggaaacg     1380

ttccagacgg ccaaagtggc ctccttcatc aaccagtact cgaccggaca gtgcaccgtc     1440

gaaatctttt gggaactcaa gaaggaaacc tccaagcgct ggaaccccga aatccagttc     1500

acctccaact ttggcaacgc ggccgacatc cagtttgccg tctccgacac gggatcctat     1560

tccgaacctc gtcccatcgg tacccgttac cttaccaaac ctctgtaa                  1608


<210>  537
<211>  2232
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  537
atgtctctca tttctgatgc gattccagat tggttggagc ggttggtcaa aaagggagtg       60

aatgctgcag ctgatttcta ccatttggaa agcggtcctc ctcgtcctaa ggcaaatcag      120

caaactcaag aatctcttga aaaggacgat tcgagaggtc tcgtgttccc aggctacaat      180

tatctaggcc ctttcaacgg tctagataaa ggagaacccg tcaacgaggc agacgctgcc      240

gccttagaac acgacaaggc ttacgacctc gaaatcaagg acgggcacaa cccgtacttt      300

gagtacaacg aggccgacag acgtttccag gaacgtctca aagacgatac ctcctttgga      360

ggcaatttag gtaaagccat cttccaggcc aaaaagaggg ttctcgaacc ctttggtctg      420

gtggaagact caaagacggc tccgaccgga gacaagcgga aaggcgaaga cgaacctcgt      480

ttgcccgaca cttcttcaca gactcccaag aaaaacaaga agcctcgcaa ggaaagacct      540

tccggcgggg cagaagatcc gggcgaaggc acctcttcca acgctggagc agcagcaccc      600

gcctctagtg tgggatcatc tatcatggct gaaggaggtg gcggcccagt gggcgatgca      660

ggccagggtg ccgatggagt gggcaattcc tccggaaatt ggcattgcga ttcccaatgg      720

ctggaaaacg gagtcgtcac tcgaaccacc cgaacctggg tcttgcccag ctacaacaac      780

cacctgtaca aacgaatcca aggacccagc ggaggcgaca acaacaacaa attctttgga      840

ttcagcaccc cctggggata ctttgactac aatcgattcc actgccactt ttccccgcga      900

gactggcaac gactcatcaa caacaactgg ggcatccgtc ccaaagcgat gcgctttaga      960

ctctttaaca tccaggttaa agaggtcacg gtccaagact tcaacaccac catcggcaac     1020

aacctcacca gtacggtcca ggtctttgcg gacaaggact accaactgcc gtacgtcctc     1080

ggatcggcta ccgaaggcac cttcccgccg ttcccagcgg atatctacac gatcccgcag     1140

tacgggtact gcacgctaaa ctacaacaac gaggcggtgg atcgttcggc cttctactgt     1200

ctggactact ttccctcaga catgctgcgg acaggaaata actttgagtt tacttacacc     1260

ttcgaggacg ttcctttcca tagcatgttt gcccacaacc agacgctaga ccggctgatg     1320

aatcccctcg tggatcagta cctctgggct ttcagctccg tcagccaagc aggctcatct     1380

ggacgagctc ttcattactc gcgggcgact aaaaccaaca tggcggctca atataggaac     1440

tggttacctg ggcctttctt ccgtgatcag caaatcttta cgggcgctag caacatcact     1500

aaaaataacg tctttagcgt ttgggaaaaa ggcaagcaat gggaactcga caatcggacc     1560

aacctaatgc agcccggtcc tgcggcagcg accaccttta gcggagaacc tgaccgtcaa     1620

gccatgcaaa acacgctggc ttttagcagg accgtctacg atcaaacgac cgccacgacc     1680

gatcgtaacc agatactcat caccaacgaa gacgaaatca gacccaccaa ctcggtcggt     1740

atcgacgcgt ggggagcagt tcccaccaac aaccagtcga tcgtgacccc cggcactcgc     1800

gcggccgtca acaatcaagg ggcgcttccc gggatggtgt ggcaaaacag agacatttac     1860

cctacaggga cccatttggc caaaattccc gacactgaca atcacttcca tccgtccccg     1920

cttattgggc ggtttggctg caagcatccc cctccccaga ttttcattaa aaacacaccc     1980

gtccctgcca acccttcgga aacgttccag acggccaaag tggcctcctt catcaaccag     2040

tactcgaccg gacagtgcac cgtcgaaatc ttttgggaac tcaagaagga aacctccaag     2100

cgctggaacc ccgaaatcca gttcacctcc aactttggca acgcggccga catccagttt     2160

gccgtctccg acacgggatc ctattccgaa cctcgtccca tcggtacccg ttaccttacc     2220

aaacctctgt aa                                                         2232


<210>  538
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  538

Met Ala Glu Gly Gly Gly Gly Pro Val Gly Asp Ala Gly Gln Gly Ala 
1               5                   10                  15      


Asp Gly Val Gly Asn Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp 
            20                  25                  30          


Leu Glu Asn Gly Val Val Thr Arg Thr Thr Arg Thr Trp Val Leu Pro 
        35                  40                  45              


Ser Tyr Asn Asn His Leu Tyr Lys Arg Ile Gln Gly Pro Ser Gly Gly 
    50                  55                  60                  


Asp Asn Asn Asn Lys Phe Phe Gly Phe Ser Thr Pro Trp Gly Tyr Phe 
65                  70                  75                  80  


Asp Tyr Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg 
                85                  90                  95      


Leu Ile Asn Asn Asn Trp Gly Ile Arg Pro Lys Ala Met Arg Phe Arg 
            100                 105                 110         


Leu Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Phe Asn Thr 
        115                 120                 125             


Thr Ile Gly Asn Asn Leu Thr Ser Thr Val Gln Val Phe Ala Asp Lys 
    130                 135                 140                 


Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala Thr Glu Gly Thr Phe 
145                 150                 155                 160 


Pro Pro Phe Pro Ala Asp Ile Tyr Thr Ile Pro Gln Tyr Gly Tyr Cys 
                165                 170                 175     


Thr Leu Asn Tyr Asn Asn Glu Ala Val Asp Arg Ser Ala Phe Tyr Cys 
            180                 185                 190         


Leu Asp Tyr Phe Pro Ser Asp Met Leu Arg Thr Gly Asn Asn Phe Glu 
        195                 200                 205             


Phe Thr Tyr Thr Phe Glu Asp Val Pro Phe His Ser Met Phe Ala His 
    210                 215                 220                 


Asn Gln Thr Leu Asp Arg Leu Met Asn Pro Leu Val Asp Gln Tyr Leu 
225                 230                 235                 240 


Trp Ala Phe Ser Ser Val Ser Gln Ala Gly Ser Ser Gly Arg Ala Leu 
                245                 250                 255     


His Tyr Ser Arg Ala Thr Lys Thr Asn Met Ala Ala Gln Tyr Arg Asn 
            260                 265                 270         


Trp Leu Pro Gly Pro Phe Phe Arg Asp Gln Gln Ile Phe Thr Gly Ala 
        275                 280                 285             


Ser Asn Ile Thr Lys Asn Asn Val Phe Ser Val Trp Glu Lys Gly Lys 
    290                 295                 300                 


Gln Trp Glu Leu Asp Asn Arg Thr Asn Leu Met Gln Pro Gly Pro Ala 
305                 310                 315                 320 


Ala Ala Thr Thr Phe Ser Gly Glu Pro Asp Arg Gln Ala Met Gln Asn 
                325                 330                 335     


Thr Leu Ala Phe Ser Arg Thr Val Tyr Asp Gln Thr Thr Ala Thr Thr 
            340                 345                 350         


Asp Arg Asn Gln Ile Leu Ile Thr Asn Glu Asp Glu Ile Arg Pro Thr 
        355                 360                 365             


Asn Ser Val Gly Ile Asp Ala Trp Gly Ala Val Pro Thr Asn Asn Gln 
    370                 375                 380                 


Ser Ile Val Thr Pro Gly Thr Arg Ala Ala Val Asn Asn Gln Gly Ala 
385                 390                 395                 400 


Leu Pro Gly Met Val Trp Gln Asn Arg Asp Ile Tyr Pro Thr Gly Thr 
                405                 410                 415     


His Leu Ala Lys Ile Pro Asp Thr Asp Asn His Phe His Pro Ser Pro 
            420                 425                 430         


Leu Ile Gly Arg Phe Gly Cys Lys His Pro Pro Pro Gln Ile Phe Ile 
        435                 440                 445             


Lys Asn Thr Pro Val Pro Ala Asn Pro Ser Glu Thr Phe Gln Thr Ala 
    450                 455                 460                 


Lys Val Ala Ser Phe Ile Asn Gln Tyr Ser Thr Gly Gln Cys Thr Val 
465                 470                 475                 480 


Glu Ile Phe Trp Glu Leu Lys Lys Glu Thr Ser Lys Arg Trp Asn Pro 
                485                 490                 495     


Glu Ile Gln Phe Thr Ser Asn Phe Gly Asn Ala Ala Asp Ile Gln Phe 
            500                 505                 510         


Ala Val Ser Asp Thr Gly Ser Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
        515                 520                 525             


Arg Tyr Leu Thr Lys Pro Leu 
    530                 535 


<210>  539
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  539

Met Glu Leu Val Asp Trp Leu Val Glu Lys Gly Ile Thr Thr Glu Lys 
1               5                   10                  15      


Glu Trp Leu Leu Glu Asn Arg Glu Ser Phe Arg Ser Phe Gln Ala Ser 
            20                  25                  30          


Ser Asn Ser Ala Arg Gln Ile Lys Thr Ala Leu Gln Gly Ala Ile Gln 
        35                  40                  45              


Glu Met Leu Leu Thr Lys Thr Ala Glu Asp Tyr Leu Val Gly Lys Asp 
    50                  55                  60                  


Pro Val Ser Asp Asp Asp Ile Arg Gln Asn Arg Ile Tyr Lys Ile Leu 
65                  70                  75                  80  


Glu Leu Asn His Tyr Asp Pro Ala Tyr Val Gly Ser Ile Leu Val Gly 
                85                  90                  95      


Trp Cys Gln Lys Lys Trp Gly Lys Arg Asn Thr Leu Trp Leu Phe Gly 
            100                 105                 110         


His Ala Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala 
        115                 120                 125             


Val Pro Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe 
    130                 135                 140                 


Asn Asp Cys Val Glu Lys Met Ile Ile Trp Trp Glu Glu Gly Lys Met 
145                 150                 155                 160 


Thr Ala Lys Val Val Glu Thr Ala Lys Ala Ile Leu Gly Gly Ser Arg 
                165                 170                 175     


Val Arg Val Asp Gln Lys Cys Lys Ala Ser Val Pro Ile Glu Pro Thr 
            180                 185                 190         


Pro Val Ile Ile Thr Ser Asn Thr Asn Met Cys Tyr Val Ile Asp Gly 
        195                 200                 205             


Asn Thr Thr Thr Phe Glu His Lys Gln Pro Leu Glu Asp Arg Met Phe 
    210                 215                 220                 


Lys Leu Glu Leu Leu Thr Arg Leu Pro Asp Asp Phe Gly Lys Val Thr 
225                 230                 235                 240 


Lys Gln Glu Val Arg Gln Phe Phe Arg Trp Ser Gln Asp His Leu Thr 
                245                 250                 255     


Pro Val Ile Pro Glu Phe Leu Val Arg Lys Ala Glu Ser Arg Lys Arg 
            260                 265                 270         


Pro Ala Pro Ser Gly Glu Gly Tyr Ile Ser Pro Thr Lys Arg Pro Ala 
        275                 280                 285             


Leu Ala Glu Gln Gln Gln Ala Ser Glu Ser Ala Asp Pro Val Pro Thr 
    290                 295                 300                 


Arg Tyr Arg Ile Lys Cys Ser Lys His Cys Gly Met Asp Lys Met Leu 
305                 310                 315                 320 


Phe Pro Cys Gln Ile Cys Glu Ser Met Asn Arg Asp Ile Asn Ile Cys 
                325                 330                 335     


Ala Ile His Lys Thr Thr Asp Cys Lys Glu Cys Phe Pro Asp Tyr Gly 
            340                 345                 350         


Asp Lys Asp Asp Val Glu Leu Pro Pro Cys Thr Glu His Asn Val Ser 
        355                 360                 365             


Arg Cys Tyr Gln Cys His Ser Gly Glu Leu Tyr Arg Val Thr Ser Asp 
    370                 375                 380                 


Ser Asp Glu Lys Pro Ala Pro Glu Ser Asp Glu Gly Thr Glu Pro Ser 
385                 390                 395                 400 


Tyr Ala Pro Cys Thr Ile His His Leu Met Gly Lys Ser His Gly Leu 
                405                 410                 415     


Val Thr Cys Ala Ala Cys Arg Leu Lys Asn Ser Thr Leu His Asp Asp 
            420                 425                 430         


Leu Asp Asp Gly Asp Leu Glu Gln 
        435                 440 


<210>  540
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  540

Met Glu Leu Val Asp Trp Leu Val Glu Lys Gly Ile Thr Thr Glu Lys 
1               5                   10                  15      


Glu Trp Leu Leu Glu Asn Arg Glu Ser Phe Arg Ser Phe Gln Ala Ser 
            20                  25                  30          


Ser Asn Ser Ala Arg Gln Ile Lys Thr Ala Leu Gln Gly Ala Ile Gln 
        35                  40                  45              


Glu Met Leu Leu Thr Lys Thr Ala Glu Asp Tyr Leu Val Gly Lys Asp 
    50                  55                  60                  


Pro Val Ser Asp Asp Asp Ile Arg Gln Asn Arg Ile Tyr Lys Ile Leu 
65                  70                  75                  80  


Glu Leu Asn His Tyr Asp Pro Ala Tyr Val Gly Ser Ile Leu Val Gly 
                85                  90                  95      


Trp Cys Gln Lys Lys Trp Gly Lys Arg Asn Thr Leu Trp Leu Phe Gly 
            100                 105                 110         


His Ala Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala 
        115                 120                 125             


Val Pro Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe 
    130                 135                 140                 


Asn Asp Cys Val Glu Lys Met Ile Ile Trp Trp Glu Glu Gly Lys Met 
145                 150                 155                 160 


Thr Ala Lys Val Val Glu Thr Ala Lys Ala Ile Leu Gly Gly Ser Arg 
                165                 170                 175     


Val Arg Val Asp Gln Lys Cys Lys Ala Ser Val Pro Ile Glu Pro Thr 
            180                 185                 190         


Pro Val Ile Ile Thr Ser Asn Thr Asn Met Cys Tyr Val Ile Asp Gly 
        195                 200                 205             


Asn Thr Thr Thr Phe Glu His Lys Gln Pro Leu Glu Asp Arg Met Phe 
    210                 215                 220                 


Lys Leu Glu Leu Leu Thr Arg Leu Pro Asp Asp Phe Gly Lys Val Thr 
225                 230                 235                 240 


Lys Gln Glu Val Arg Gln Phe Phe Arg Trp Ser Gln Asp His Leu Thr 
                245                 250                 255     


Pro Val Ile Pro Glu Phe Leu Val Arg Lys Ala Glu Ser Arg Lys Arg 
            260                 265                 270         


Pro Ala Pro Ser Gly Glu Gly Tyr Ile Ser Pro Thr Lys Arg Pro Ala 
        275                 280                 285             


Leu Ala Glu Gln Gln Gln Ala Ser Glu Ser Ala Asp Pro Val Pro Thr 
    290                 295                 300                 


Arg Leu Val Gly Ala Val Gly Gln Lys Gly Ser Glu Cys Cys Ser 
305                 310                 315                 


<210>  541
<211>  662
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  541

Met Arg Ser Tyr Tyr Glu Val Ile Val Gln Leu Pro Asn Asp Val Glu 
1               5                   10                  15      


Ser Gln Val Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Ile Thr Ser 
            20                  25                  30          


Arg Glu Trp Thr Leu Pro Glu Asp Ala Asp Trp Asp Leu Asp Gln Val 
        35                  40                  45              


Asp Gln Val Gln Leu Thr Leu Gly Asp Lys Ile Gln Arg Glu Ile Arg 
    50                  55                  60                  


Thr His Trp Gly Thr Met Ala Lys Glu Pro Asp Phe His Tyr Phe Ile 
65                  70                  75                  80  


Gln Leu Glu Gln Gly Glu Val Phe Phe His Leu His Val Leu Leu Glu 
                85                  90                  95      


Thr Cys Ser Val Lys Pro Met Val Leu Gly Arg Tyr Ile Arg His Ile 
            100                 105                 110         


Gln Gln Lys Ile Val Ser Lys Val Tyr Cys Ala Thr Ser Leu Arg Trp 
        115                 120                 125             


Lys Asp Gly Cys Val Val Thr Lys Thr Lys Asn Phe Gly Gly Ala Asn 
    130                 135                 140                 


Lys Val Arg Ala Glu Ser Tyr Ile Pro Ala Tyr Leu Ile Pro Lys Gln 
145                 150                 155                 160 


Gln Pro Glu Val Gln Trp Ala Trp Thr Asn Val Pro Glu Tyr Ile Lys 
                165                 170                 175     


Ala Cys Leu His Arg Glu Leu Arg Ala Ser Leu Ala Arg Leu His Phe 
            180                 185                 190         


Glu Glu Ala Gly Val Ser Gln Ser Lys Glu Asn Leu Ala Arg Thr Ala 
        195                 200                 205             


Asp Gly Ala Pro Val Met Pro Thr Arg Val Ser Lys Arg Tyr Met Glu 
    210                 215                 220                 


Leu Val Asp Trp Leu Val Glu Lys Gly Ile Thr Thr Glu Lys Glu Trp 
225                 230                 235                 240 


Leu Leu Glu Asn Arg Glu Ser Phe Arg Ser Phe Gln Ala Ser Ser Asn 
                245                 250                 255     


Ser Ala Arg Gln Ile Lys Thr Ala Leu Gln Gly Ala Ile Gln Glu Met 
            260                 265                 270         


Leu Leu Thr Lys Thr Ala Glu Asp Tyr Leu Val Gly Lys Asp Pro Val 
        275                 280                 285             


Ser Asp Asp Asp Ile Arg Gln Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
    290                 295                 300                 


Asn His Tyr Asp Pro Ala Tyr Val Gly Ser Ile Leu Val Gly Trp Cys 
305                 310                 315                 320 


Gln Lys Lys Trp Gly Lys Arg Asn Thr Leu Trp Leu Phe Gly His Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Glu Lys Met Ile Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Thr Ala Lys Ala Ile Leu Gly Gly Ser Arg Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ala Ser Val Pro Ile Glu Pro Thr Pro Val 
                405                 410                 415     


Ile Ile Thr Ser Asn Thr Asn Met Cys Tyr Val Ile Asp Gly Asn Thr 
            420                 425                 430         


Thr Thr Phe Glu His Lys Gln Pro Leu Glu Asp Arg Met Phe Lys Leu 
        435                 440                 445             


Glu Leu Leu Thr Arg Leu Pro Asp Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Arg Gln Phe Phe Arg Trp Ser Gln Asp His Leu Thr Pro Val 
465                 470                 475                 480 


Ile Pro Glu Phe Leu Val Arg Lys Ala Glu Ser Arg Lys Arg Pro Ala 
                485                 490                 495     


Pro Ser Gly Glu Gly Tyr Ile Ser Pro Thr Lys Arg Pro Ala Leu Ala 
            500                 505                 510         


Glu Gln Gln Gln Ala Ser Glu Ser Ala Asp Pro Val Pro Thr Arg Tyr 
        515                 520                 525             


Arg Ile Lys Cys Ser Lys His Cys Gly Met Asp Lys Met Leu Phe Pro 
    530                 535                 540                 


Cys Gln Ile Cys Glu Ser Met Asn Arg Asp Ile Asn Ile Cys Ala Ile 
545                 550                 555                 560 


His Lys Thr Thr Asp Cys Lys Glu Cys Phe Pro Asp Tyr Gly Asp Lys 
                565                 570                 575     


Asp Asp Val Glu Leu Pro Pro Cys Thr Glu His Asn Val Ser Arg Cys 
            580                 585                 590         


Tyr Gln Cys His Ser Gly Glu Leu Tyr Arg Val Thr Ser Asp Ser Asp 
        595                 600                 605             


Glu Lys Pro Ala Pro Glu Ser Asp Glu Gly Thr Glu Pro Ser Tyr Ala 
    610                 615                 620                 


Pro Cys Thr Ile His His Leu Met Gly Lys Ser His Gly Leu Val Thr 
625                 630                 635                 640 


Cys Ala Ala Cys Arg Leu Lys Asn Ser Thr Leu His Asp Asp Leu Asp 
                645                 650                 655     


Asp Gly Asp Leu Glu Gln 
            660         


<210>  542
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  542

Met Arg Ser Tyr Tyr Glu Val Ile Val Gln Leu Pro Asn Asp Val Glu 
1               5                   10                  15      


Ser Gln Val Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Ile Thr Ser 
            20                  25                  30          


Arg Glu Trp Thr Leu Pro Glu Asp Ala Asp Trp Asp Leu Asp Gln Val 
        35                  40                  45              


Asp Gln Val Gln Leu Thr Leu Gly Asp Lys Ile Gln Arg Glu Ile Arg 
    50                  55                  60                  


Thr His Trp Gly Thr Met Ala Lys Glu Pro Asp Phe His Tyr Phe Ile 
65                  70                  75                  80  


Gln Leu Glu Gln Gly Glu Val Phe Phe His Leu His Val Leu Leu Glu 
                85                  90                  95      


Thr Cys Ser Val Lys Pro Met Val Leu Gly Arg Tyr Ile Arg His Ile 
            100                 105                 110         


Gln Gln Lys Ile Val Ser Lys Val Tyr Cys Ala Thr Ser Leu Arg Trp 
        115                 120                 125             


Lys Asp Gly Cys Val Val Thr Lys Thr Lys Asn Phe Gly Gly Ala Asn 
    130                 135                 140                 


Lys Val Arg Ala Glu Ser Tyr Ile Pro Ala Tyr Leu Ile Pro Lys Gln 
145                 150                 155                 160 


Gln Pro Glu Val Gln Trp Ala Trp Thr Asn Val Pro Glu Tyr Ile Lys 
                165                 170                 175     


Ala Cys Leu His Arg Glu Leu Arg Ala Ser Leu Ala Arg Leu His Phe 
            180                 185                 190         


Glu Glu Ala Gly Val Ser Gln Ser Lys Glu Asn Leu Ala Arg Thr Ala 
        195                 200                 205             


Asp Gly Ala Pro Val Met Pro Thr Arg Val Ser Lys Arg Tyr Met Glu 
    210                 215                 220                 


Leu Val Asp Trp Leu Val Glu Lys Gly Ile Thr Thr Glu Lys Glu Trp 
225                 230                 235                 240 


Leu Leu Glu Asn Arg Glu Ser Phe Arg Ser Phe Gln Ala Ser Ser Asn 
                245                 250                 255     


Ser Ala Arg Gln Ile Lys Thr Ala Leu Gln Gly Ala Ile Gln Glu Met 
            260                 265                 270         


Leu Leu Thr Lys Thr Ala Glu Asp Tyr Leu Val Gly Lys Asp Pro Val 
        275                 280                 285             


Ser Asp Asp Asp Ile Arg Gln Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
    290                 295                 300                 


Asn His Tyr Asp Pro Ala Tyr Val Gly Ser Ile Leu Val Gly Trp Cys 
305                 310                 315                 320 


Gln Lys Lys Trp Gly Lys Arg Asn Thr Leu Trp Leu Phe Gly His Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Glu Lys Met Ile Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Thr Ala Lys Ala Ile Leu Gly Gly Ser Arg Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ala Ser Val Pro Ile Glu Pro Thr Pro Val 
                405                 410                 415     


Ile Ile Thr Ser Asn Thr Asn Met Cys Tyr Val Ile Asp Gly Asn Thr 
            420                 425                 430         


Thr Thr Phe Glu His Lys Gln Pro Leu Glu Asp Arg Met Phe Lys Leu 
        435                 440                 445             


Glu Leu Leu Thr Arg Leu Pro Asp Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Arg Gln Phe Phe Arg Trp Ser Gln Asp His Leu Thr Pro Val 
465                 470                 475                 480 


Ile Pro Glu Phe Leu Val Arg Lys Ala Glu Ser Arg Lys Arg Pro Ala 
                485                 490                 495     


Pro Ser Gly Glu Gly Tyr Ile Ser Pro Thr Lys Arg Pro Ala Leu Ala 
            500                 505                 510         


Glu Gln Gln Gln Ala Ser Glu Ser Ala Asp Pro Val Pro Thr Arg Leu 
        515                 520                 525             


Val Gly Ala Val Gly Gln Lys Gly Ser Glu Cys Cys Ser 
    530                 535                 540     


<210>  543
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  543

Met Ser Leu Ile Ser Asp Ala Ile Pro Asp Trp Leu Glu Arg Leu Val 
1               5                   10                  15      


Lys Lys Gly Val Asn Ala Ala Ala Asp Phe Tyr His Leu Glu Ser Gly 
            20                  25                  30          


Pro Pro Arg Pro Lys Ala Asn Gln Gln Thr Gln Glu Ser Leu Glu Lys 
        35                  40                  45              


Asp Asp Ser Arg Gly Leu Val Phe Pro Gly Tyr Asn Tyr Leu Gly Pro 
    50                  55                  60                  


Phe Asn Gly Leu Asp Lys Gly Glu Pro Val Asn Glu Ala Asp Ala Ala 
65                  70                  75                  80  


Ala Leu Glu His Asp Lys Ala Tyr Asp Leu Glu Ile Lys Asp Gly His 
                85                  90                  95      


Asn Pro Tyr Phe Glu Tyr Asn Glu Ala Asp Arg Arg Phe Gln Glu Arg 
            100                 105                 110         


Leu Lys Asp Asp Thr Ser Phe Gly Gly Asn Leu Gly Lys Ala Ile Phe 
        115                 120                 125             


Gln Ala Lys Lys Arg Val Leu Glu Pro Phe Gly Leu Val Glu Asp Ser 
    130                 135                 140                 


Lys Thr Ala Pro Thr Gly Asp Lys Arg Lys Gly Glu Asp Glu Pro Arg 
145                 150                 155                 160 


Leu Pro Asp Thr Ser Ser Gln Thr Pro Lys Lys Asn Lys Lys Pro Arg 
                165                 170                 175     


Lys Glu Arg Pro Ser Gly Gly Ala Glu Asp Pro Gly Glu Gly Thr Ser 
            180                 185                 190         


Ser Asn Ala Gly Ala Ala Ala Pro Ala Ser Ser Val Gly Ser Ser Ile 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gly Pro Val Gly Asp Ala Gly Gln Gly Ala 
    210                 215                 220                 


Asp Gly Val Gly Asn Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp 
225                 230                 235                 240 


Leu Glu Asn Gly Val Val Thr Arg Thr Thr Arg Thr Trp Val Leu Pro 
                245                 250                 255     


Ser Tyr Asn Asn His Leu Tyr Lys Arg Ile Gln Gly Pro Ser Gly Gly 
            260                 265                 270         


Asp Asn Asn Asn Lys Phe Phe Gly Phe Ser Thr Pro Trp Gly Tyr Phe 
        275                 280                 285             


Asp Tyr Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg 
    290                 295                 300                 


Leu Ile Asn Asn Asn Trp Gly Ile Arg Pro Lys Ala Met Arg Phe Arg 
305                 310                 315                 320 


Leu Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Phe Asn Thr 
                325                 330                 335     


Thr Ile Gly Asn Asn Leu Thr Ser Thr Val Gln Val Phe Ala Asp Lys 
            340                 345                 350         


Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala Thr Glu Gly Thr Phe 
        355                 360                 365             


Pro Pro Phe Pro Ala Asp Ile Tyr Thr Ile Pro Gln Tyr Gly Tyr Cys 
    370                 375                 380                 


Thr Leu Asn Tyr Asn Asn Glu Ala Val Asp Arg Ser Ala Phe Tyr Cys 
385                 390                 395                 400 


Leu Asp Tyr Phe Pro Ser Asp Met Leu Arg Thr Gly Asn Asn Phe Glu 
                405                 410                 415     


Phe Thr Tyr Thr Phe Glu Asp Val Pro Phe His Ser Met Phe Ala His 
            420                 425                 430         


Asn Gln Thr Leu Asp Arg Leu Met Asn Pro Leu Val Asp Gln Tyr Leu 
        435                 440                 445             


Trp Ala Phe Ser Ser Val Ser Gln Ala Gly Ser Ser Gly Arg Ala Leu 
    450                 455                 460                 


His Tyr Ser Arg Ala Thr Lys Thr Asn Met Ala Ala Gln Tyr Arg Asn 
465                 470                 475                 480 


Trp Leu Pro Gly Pro Phe Phe Arg Asp Gln Gln Ile Phe Thr Gly Ala 
                485                 490                 495     


Ser Asn Ile Thr Lys Asn Asn Val Phe Ser Val Trp Glu Lys Gly Lys 
            500                 505                 510         


Gln Trp Glu Leu Asp Asn Arg Thr Asn Leu Met Gln Pro Gly Pro Ala 
        515                 520                 525             


Ala Ala Thr Thr Phe Ser Gly Glu Pro Asp Arg Gln Ala Met Gln Asn 
    530                 535                 540                 


Thr Leu Ala Phe Ser Arg Thr Val Tyr Asp Gln Thr Thr Ala Thr Thr 
545                 550                 555                 560 


Asp Arg Asn Gln Ile Leu Ile Thr Asn Glu Asp Glu Ile Arg Pro Thr 
                565                 570                 575     


Asn Ser Val Gly Ile Asp Ala Trp Gly Ala Val Pro Thr Asn Asn Gln 
            580                 585                 590         


Ser Ile Val Thr Pro Gly Thr Arg Ala Ala Val Asn Asn Gln Gly Ala 
        595                 600                 605             


Leu Pro Gly Met Val Trp Gln Asn Arg Asp Ile Tyr Pro Thr Gly Thr 
    610                 615                 620                 


His Leu Ala Lys Ile Pro Asp Thr Asp Asn His Phe His Pro Ser Pro 
625                 630                 635                 640 


Leu Ile Gly Arg Phe Gly Cys Lys His Pro Pro Pro Gln Ile Phe Ile 
                645                 650                 655     


Lys Asn Thr Pro Val Pro Ala Asn Pro Ser Glu Thr Phe Gln Thr Ala 
            660                 665                 670         


Lys Val Ala Ser Phe Ile Asn Gln Tyr Ser Thr Gly Gln Cys Thr Val 
        675                 680                 685             


Glu Ile Phe Trp Glu Leu Lys Lys Glu Thr Ser Lys Arg Trp Asn Pro 
    690                 695                 700                 


Glu Ile Gln Phe Thr Ser Asn Phe Gly Asn Ala Ala Asp Ile Gln Phe 
705                 710                 715                 720 


Ala Val Ser Asp Thr Gly Ser Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
                725                 730                 735     


Arg Tyr Leu Thr Lys Pro Leu 
            740             


<210>  544
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  544

Thr Ala Pro Thr Gly Asp Lys Arg Lys Gly Glu Asp Glu Pro Arg Leu 
1               5                   10                  15      


Pro Asp Thr Ser Ser Gln Thr Pro Lys Lys Asn Lys Lys Pro Arg Lys 
            20                  25                  30          


Glu Arg Pro Ser Gly Gly Ala Glu Asp Pro Gly Glu Gly Thr Ser Ser 
        35                  40                  45              


Asn Ala Gly Ala Ala Ala Pro Ala Ser Ser Val Gly Ser Ser Ile Met 
    50                  55                  60                  


Ala Glu Gly Gly Gly Gly Pro Val Gly Asp Ala Gly Gln Gly Ala Asp 
65                  70                  75                  80  


Gly Val Gly Asn Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu 
                85                  90                  95      


Glu Asn Gly Val Val Thr Arg Thr Thr Arg Thr Trp Val Leu Pro Ser 
            100                 105                 110         


Tyr Asn Asn His Leu Tyr Lys Arg Ile Gln Gly Pro Ser Gly Gly Asp 
        115                 120                 125             


Asn Asn Asn Lys Phe Phe Gly Phe Ser Thr Pro Trp Gly Tyr Phe Asp 
    130                 135                 140                 


Tyr Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu 
145                 150                 155                 160 


Ile Asn Asn Asn Trp Gly Ile Arg Pro Lys Ala Met Arg Phe Arg Leu 
                165                 170                 175     


Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Phe Asn Thr Thr 
            180                 185                 190         


Ile Gly Asn Asn Leu Thr Ser Thr Val Gln Val Phe Ala Asp Lys Asp 
        195                 200                 205             


Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala Thr Glu Gly Thr Phe Pro 
    210                 215                 220                 


Pro Phe Pro Ala Asp Ile Tyr Thr Ile Pro Gln Tyr Gly Tyr Cys Thr 
225                 230                 235                 240 


Leu Asn Tyr Asn Asn Glu Ala Val Asp Arg Ser Ala Phe Tyr Cys Leu 
                245                 250                 255     


Asp Tyr Phe Pro Ser Asp Met Leu Arg Thr Gly Asn Asn Phe Glu Phe 
            260                 265                 270         


Thr Tyr Thr Phe Glu Asp Val Pro Phe His Ser Met Phe Ala His Asn 
        275                 280                 285             


Gln Thr Leu Asp Arg Leu Met Asn Pro Leu Val Asp Gln Tyr Leu Trp 
    290                 295                 300                 


Ala Phe Ser Ser Val Ser Gln Ala Gly Ser Ser Gly Arg Ala Leu His 
305                 310                 315                 320 


Tyr Ser Arg Ala Thr Lys Thr Asn Met Ala Ala Gln Tyr Arg Asn Trp 
                325                 330                 335     


Leu Pro Gly Pro Phe Phe Arg Asp Gln Gln Ile Phe Thr Gly Ala Ser 
            340                 345                 350         


Asn Ile Thr Lys Asn Asn Val Phe Ser Val Trp Glu Lys Gly Lys Gln 
        355                 360                 365             


Trp Glu Leu Asp Asn Arg Thr Asn Leu Met Gln Pro Gly Pro Ala Ala 
    370                 375                 380                 


Ala Thr Thr Phe Ser Gly Glu Pro Asp Arg Gln Ala Met Gln Asn Thr 
385                 390                 395                 400 


Leu Ala Phe Ser Arg Thr Val Tyr Asp Gln Thr Thr Ala Thr Thr Asp 
                405                 410                 415     


Arg Asn Gln Ile Leu Ile Thr Asn Glu Asp Glu Ile Arg Pro Thr Asn 
            420                 425                 430         


Ser Val Gly Ile Asp Ala Trp Gly Ala Val Pro Thr Asn Asn Gln Ser 
        435                 440                 445             


Ile Val Thr Pro Gly Thr Arg Ala Ala Val Asn Asn Gln Gly Ala Leu 
    450                 455                 460                 


Pro Gly Met Val Trp Gln Asn Arg Asp Ile Tyr Pro Thr Gly Thr His 
465                 470                 475                 480 


Leu Ala Lys Ile Pro Asp Thr Asp Asn His Phe His Pro Ser Pro Leu 
                485                 490                 495     


Ile Gly Arg Phe Gly Cys Lys His Pro Pro Pro Gln Ile Phe Ile Lys 
            500                 505                 510         


Asn Thr Pro Val Pro Ala Asn Pro Ser Glu Thr Phe Gln Thr Ala Lys 
        515                 520                 525             


Val Ala Ser Phe Ile Asn Gln Tyr Ser Thr Gly Gln Cys Thr Val Glu 
    530                 535                 540                 


Ile Phe Trp Glu Leu Lys Lys Glu Thr Ser Lys Arg Trp Asn Pro Glu 
545                 550                 555                 560 


Ile Gln Phe Thr Ser Asn Phe Gly Asn Ala Ala Asp Ile Gln Phe Ala 
                565                 570                 575     


Val Ser Asp Thr Gly Ser Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg 
            580                 585                 590         


Tyr Leu Thr Lys Pro Leu 
        595             


<210>  545
<211>  4694
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  545
tggccagttt ccaagacagg ctcgctcgct cactcgggcc ggggccccaa aggggcccct       60

agcgaccgct tcgcggtcgc ggcccgagtg agcgagcgag cctgtcttgg aaactggcca      120

gcactccggt gaggtaatgc cgtcacgtgg tcgggaatgg gaacgggaaa tctcgcgaga      180

acgtaaacaa atataagacg gcgccacacg gcgctgcgtc atacgcgcgc gcgcaccggc      240

gagatgaggt cgtactacga ggtcatcgtt cagctgccca acgacgtcga gagtcaggta      300

cctggaatct ccgattcgtt cgtcaactgg attacgtcgc gagaatggac gttgcctgag      360

gacgccgatt gggatttgga ccaggtcgat caagttcaac tgacgctcgg cgacaaaatc      420

caacgggaga ttcgaactca ttgggggacg atggccaaag aaccggactt tcactatttt      480

atccaactgg aacaaggtga ggtgttcttt catttacacg tcctgctgga aacgtgttcc      540

gtaaagccga tggtactcgg aagatatatc cgacatattc aacaaaaaat tgtgagtaaa      600

gtctactgcg ccacgagcct acgatggaag gatggatgcg tggtgaccaa gaccaaaaat      660

ttcgggggcg cgaacaaggt ccgggccgag tcgtatattc ccgcctacct gatcccgaaa      720

cagcaaccgg aagtgcagtg ggcgtggact aacgtgcccg agtatataaa agcgtgcttg      780

caccgagaac tgcgtgccag tctcgcgcga cttcacttcg aggaggcggg cgtctcgcaa      840

tccaaggaaa atctcgcgag aactgcagac ggcgctcccg tgatgccgac ccgcgtcagc      900

aaacgctaca tggagctcgt ggattggctc gtggagaagg ggatcaccac cgagaaggaa      960

tggctgctgg aaaacagaga aagctttcgg agctttcagg cctcgagcaa ctcggcgcgt     1020

cagatcaaga cggccctgca aggcgccatt caggagatgc ttctgaccaa gacggcggag     1080

gactacctcg tcggaaagga tcccgtctcg gacgacgaca tccgtcagaa ccgcatctac     1140

aagattctgg aactgaacca ctacgaccca gcgtacgtgg ggagtatttt ggtcgggtgg     1200

tgccagaaga aatggggcaa gcgaaacacg ctgtggctgt tcggacatgc gaccaccggc     1260

aagaccaaca tcgcggaggc tattgcccat gctgtgccgt tctatggatg cgttaactgg     1320

accaacgaga actttccgtt caacgactgc gtcgaaaaaa tgattatctg gtgggaggag     1380

ggcaaaatga ccgccaaagt ggtggaaaca gccaaggcga ttctgggagg atctcgggtg     1440

agagtggacc aaaaatgcaa agcttcggtt ccgatcgaac cgacgccggt cattattacc     1500

agtaacacca acatgtgtta tgtcatcgac gggaacacga ccacgttcga gcataagcag     1560

ccgttggagg acaggatgtt taagctcgaa ttgctgactc ggttgcctga tgactttggt     1620

aaggtgacca aacaggaggt gcgtcaattc ttcaggtggt ctcaggatca cctgacccct     1680

gtgatcccag aattcctagt gcggaaggcg gagtctcgca aaagacccgc cccttccggg     1740

gaaggctata taagcccgac aaagcggccc gcgctcgcag agcagcagca ggcgtcggag     1800

agcgcggacc cggttcccac caggtatcgt atcaaatgct cgaaacattg cggtatggat     1860

aaaatgttgt ttccttgcca aatttgtgaa tcgatgaaca gagatattaa tatttgtgct     1920

attcataaaa cgaccgactg taaagagtgt ttccccgact acggggataa agatgatgta     1980

gaactacccc cctgtacaga acacaacgtg tctcgttgtt atcaatgtca ttcgggcgaa     2040

ttgtatcgcg tgacttcgga ctctgacgag aaacctgccc ccgagagtga tgaaggcacc     2100

gagccatcct atgctccctg cacgattcac cacctgatgg gcaagagtca cgggttagtc     2160

acttgcgcgg cgtgtcggtt gaaaaatagt acgttgcatg atgacttgga tgacggtgat     2220

ctcgaacaat aaatgattga aatgtagcca tgtctctcat ttctgatgcg attccagatt     2280

ggttggagcg gttggtcaaa aagggagtga atgctgcagc tgatttctac catttggaaa     2340

gcggtcctcc tcgtcctaag gcaaatcagc aaactcaaga atctcttgaa aaggacgatt     2400

cgagaggtct cgtgttccca ggctacaatt atctaggccc tttcaacggt ctagataaag     2460

gagaacccgt caacgaggca gacgctgccg ccttagaaca cgacaaggct tacgacctcg     2520

aaatcaagga cgggcacaac ccgtactttg agtacaacga ggccgacaga cgtttccagg     2580

aacgtctcaa agacgatacc tcctttggag gcaatttagg taaagccatc ttccaggcca     2640

aaaagagggt tctcgaaccc tttggtctgg tggaagactc aaagacggct ccgaccggag     2700

acaagcggaa aggcgaagac gaacctcgtt tgcccgacac ttcttcacag actcccaaga     2760

aaaacaagaa gcctcgcaag gaaagacctt ccggcggggc agaagatccg ggcgaaggca     2820

cctcttccaa cgctggagca gcagcacccg cctctagtgt gggatcatct atcatggctg     2880

aaggaggtgg cggcccagtg ggcgatgcag gccagggtgc cgatggagtg ggcaattcct     2940

ccggaaattg gcattgcgat tcccaatggc tggaaaacgg agtcgtcact cgaaccaccc     3000

gaacctgggt cttgcccagc tacaacaacc acctgtacaa acgaatccaa ggacccagcg     3060

gaggcgacaa caacaacaaa ttctttggat tcagcacccc ctggggatac tttgactaca     3120

atcgattcca ctgccacttt tccccgcgag actggcaacg actcatcaac aacaactggg     3180

gcatccgtcc caaagcgatg cgctttagac tctttaacat ccaggttaaa gaggtcacgg     3240

tccaagactt caacaccacc atcggcaaca acctcaccag tacggtccag gtctttgcgg     3300

acaaggacta ccaactgccg tacgtcctcg gatcggctac cgaaggcacc ttcccgccgt     3360

tcccagcgga tatctacacg atcccgcagt acgggtactg cacgctaaac tacaacaacg     3420

aggcggtgga tcgttcggcc ttctactgtc tggactactt tccctcagac atgctgcgga     3480

caggaaataa ctttgagttt acttacacct tcgaggacgt tcctttccat agcatgtttg     3540

cccacaacca gacgctagac cggctgatga atcccctcgt ggatcagtac ctctgggctt     3600

tcagctccgt cagccaagca ggctcatctg gacgagctct tcattactcg cgggcgacta     3660

aaaccaacat ggcggctcaa tataggaact ggttacctgg gcctttcttc cgtgatcagc     3720

aaatctttac gggcgctagc aacatcacta aaaataacgt ctttagcgtt tgggaaaaag     3780

gcaagcaatg ggaactcgac aatcggacca acctaatgca gcccggtcct gcggcagcga     3840

ccacctttag cggagaacct gaccgtcaag ccatgcaaaa cacgctggct tttagcagga     3900

ccgtctacga tcaaacgacc gccacgaccg atcgtaacca gatactcatc accaacgaag     3960

acgaaatcag acccaccaac tcggtcggta tcgacgcgtg gggagcagtt cccaccaaca     4020

accagtcgat cgtgaccccc ggcactcgcg cggccgtcaa caatcaaggg gcgcttcccg     4080

ggatggtgtg gcaaaacaga gacatttacc ctacagggac ccatttggcc aaaattcccg     4140

acactgacaa tcacttccat ccgtccccgc ttattgggcg gtttggctgc aagcatcccc     4200

ctccccagat tttcattaaa aacacacccg tccctgccaa cccttcggaa acgttccaga     4260

cggccaaagt ggcctccttc atcaaccagt actcgaccgg acagtgcacc gtcgaaatct     4320

tttgggaact caagaaggaa acctccaagc gctggaaccc cgaaatccag ttcacctcca     4380

actttggcaa cgcggccgac atccagtttg ccgtctccga cacgggatcc tattccgaac     4440

ctcgtcccat cggtacccgt taccttacca aacctctgta aattaaaccc ttcaataaac     4500

cgtttatgcg taactgtatt tccgtctcct gtcgttattc agtcacatga tgcggcatta     4560

cctcaccgga gtgctggcca gtttccaaga caggctcgct cgctcactcg ggccggggcc     4620

ccaaaggggc ccctagcgac cgcttcgcgg tcgcggcccg agtgagcgag cgagcctgtc     4680

ttggaaactg gcca                                                       4694


<210>  546
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  546
atggctgctg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggtga caacccctac ctcaagtaca accacgccga cgcggagttc      300

cagcagcggc ttcagggcga cacatcgttt gggggcaacc tcggcagagc agtcttccag      360

gccaaaaaga gggttcttga acctcttggt ctggttgagc aagcgggtga gacggctcct      420

ggaaagaaga gaccgttgat tgaatccccc cagcagcccg actcctccac gggtatcggc      480

aaaaaaggca agcagccggc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggtgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg acttcaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc agactatcag ctcccgtacg tgctcgggtc ggctcacgag     1080

ggctgcctcc cgccgttccc agcagacgtc ttcatggtgc cacagtatgg atacctcacc     1140

ctgaacaacg ggagtcaggc agtaggacgc tcttcatttt actgcctgga gtactttcct     1200

tctcagatgc tgcgtaccgg aaacaacttt accttcagct acacttttga ggacgttcct     1260

ttccacagca gctacgctca cagccagagt ctggaccgtc tcatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgggggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac aaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210>  547
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  547

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Gln Arg Leu Gln Gly Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Gln Ala Gly Glu Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Leu Ile Glu Ser Pro Gln Gln Pro Asp Ser Ser Thr Gly Ile Gly 
145                 150                 155                 160 


Lys Lys Gly Lys Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Asp Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  548
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  548
atggcttccg atggttatct tccagattgg ctcgaggaca acctctctga gggcatccgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca gagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc catttctcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaggc agtgggacgg tcatcctttt actgcctgga atatttccca     1200

tcgcagatgc tgagaacggg caataacttt accttcagct acaccttcga ggacgtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgggggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt accggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac aaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactt     1920

aagcacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggca     1980

gagttttcgg ctacaaagtt tgcttcattc atcacccagt attctactgg ccaagtcagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgtcccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210>  549
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  549

Met Ala Ser Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Arg Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  550
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  550
atggctgctg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggtga caacccctac ctcaagtaca accacgccga cgcggagttc      300

cagcagcggc ttcagggcga cacatcgttt gggggcaacc tcggcagagc agtcttccag      360

gccaaaaaga gggttcttga acctcttggt ctggttgagc aagcgggtga gacggctcct      420

ggaaagaaga gaccgttgat tgaatccccc cagcagcccg actcctccac gggtatcggc      480

aaaaaaggca agcagccggc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggtgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg acttcaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc agactatcag ctcccgtacg tgctcgggtc ggctcacgag     1080

ggctgcctcc cgccgttccc agcagacgtc ttcatggtgc cacagtatgg atacctcacc     1140

ctgaacaacg ggagtcaggc agtaggacgc tcttcatttt actgcctgga gtactttcct     1200

tctcagatgc tgcgtaccgg aaacaacttt accttcagct acacttttga ggacgttcct     1260

ttccacagca gctacgctca cagccagagt ctggaccgtc tcatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgggggtc tccaactggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac aaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ctgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgccatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacggatgg acactttcac ccgtctcctc tcatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccagt attccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210>  551
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  551

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Gln Arg Leu Gln Gly Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Gln Ala Gly Glu Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Leu Ile Glu Ser Pro Gln Gln Pro Asp Ser Ser Thr Gly Ile Gly 
145                 150                 155                 160 


Lys Lys Gly Lys Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Asp Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Thr Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  552
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  552
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcaatcgcca caagagccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt cgacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg actttaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaaca actggggatt ccggcccaag agactcagct tcaagctctt caacatccag      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgat     1320

caatacctgt attacctgaa cagaactcaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca taaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac attgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtccccagta a              2211


<210>  553
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  553

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Ile Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Gln 
                725                 730                 735     


<210>  554
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  554
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac cttcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga gggttctcga acctctcggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg acttcaacag attccactgc cacttttcac cacgtgactg gcaaagactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaggc agtgggacgg tcatcctttt actgcctgga atatttccca     1200

tcgcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt accggcagca gtgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac aaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210>  555
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  555

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Cys Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  556
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  556
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gaatggtggg acttgaaacc tggagccccg aaacccaaag tcaaccagca aaagcaggac      120

aacgctcggg gtcttgtgct tccgggttac aaatacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac cttcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc ttggacgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg acttcaacag attccactgc cacttttcac cacgtgactg gcaaagactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaggc agtgggacgg tcatcctttt actgcctgga atatttccca     1200

tcgcagatgc tgagaacggg caataacttt accttcagct acacttttga ggacgttcct     1260

ttccacagca gctacgctca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccaactggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ctgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgccatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacggatgg acactttcac ccgtctcctc tcatgggcgg ctttggactt     1920

aagcacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggca     1980

gagttttcgg ctacaaagtt tgcttcattc atcacccagt attccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210>  557
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  557

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Val Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Thr Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  558
<211>  2208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide


<220>
<221>  modified_base
<222>  (955)..(955)
<223>  n = a, c, t, or g

<220>
<221>  misc_feature
<222>  (955)..(955)
<223>  n is a, c, g, or t

<220>
<221>  modified_base
<222>  (971)..(972)
<223>  n = a, c, t, or g

<220>
<221>  misc_feature
<222>  (971)..(972)
<223>  n is a, c, g, or t

<220>
<221>  modified_base
<222>  (981)..(981)
<223>  n = a, c, t, or g

<220>
<221>  misc_feature
<222>  (981)..(981)
<223>  n is a, c, g, or t

<220>
<221>  modified_base
<222>  (986)..(986)
<223>  n = a, c, t, or g

<220>
<221>  misc_feature
<222>  (986)..(986)
<223>  n is a, c, g, or t

<220>
<221>  modified_base
<222>  (1235)..(1235)
<223>  n = a, c, t, or g

<220>
<221>  misc_feature
<222>  (1235)..(1235)
<223>  n is a, c, g, or t

<220>
<221>  modified_base
<222>  (1694)..(1696)
<223>  n = a, c, t, or g

<220>
<221>  misc_feature
<222>  (1694)..(1696)
<223>  n is a, c, g, or t

<220>
<221>  modified_base
<222>  (1698)..(1698)
<223>  n = a, c, t, or g

<220>
<221>  misc_feature
<222>  (1698)..(1698)
<223>  n is a, c, g, or t

<220>
<221>  modified_base
<222>  (1763)..(1765)
<223>  n = a, c, t, or g

<220>
<221>  misc_feature
<222>  (1763)..(1765)
<223>  n is a, c, g, or t

<220>
<221>  modified_base
<222>  (1778)..(1778)
<223>  n = a, c, t, or g

<220>
<221>  misc_feature
<222>  (1778)..(1778)
<223>  n is a, c, g, or t

<220>
<221>  modified_base
<222>  (2204)..(2204)
<223>  n = a, c, t, or g

<220>
<221>  misc_feature
<222>  (2204)..(2204)
<223>  n is a, c, g, or t

<400>  558
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gaatggtggg acttgaaacc tggagccccg aaacccaaag tcaaccagca aaagcaggac      120

aacgctcggg gtcttgtgct tccgggttac aaatacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac cttcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc ttggacgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaataaca attggggatt ccggcccaag agactcaact tcaaactctt caacntccaa      960

gtcaaggagg nnacgacgaa ngatgncgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaggc agtgggacgg tcatcctttt actgcctgga atatttccca     1200

tcgcagatgc tgagaacggg caataacttt acctncagct acacttttga ggacgttcct     1260

ttccacagca gctacgctca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccaactggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag agannncnaa gccactaacc ccgtggccac tgaaagattt gggactgtgg     1740

cagtcaatct ccaagcagca cannnaccct gcgaccgnag atgtgcatgc catgggagcc     1800

ttacctggaa tggtgtggca agacagagac gtatacctgc agggtcctat ttgggccaaa     1860

attcctcaca cggatggaca ctttcacccg tctcctctca tgggcggctt tggacttaag     1920

cacccgcctc ctcagatcct catcaaaaac acgcctgttc ctgcgaatcc tccggcagag     1980

ttttcggcta caaagtttgc ttcattcatc acccagtatt ccacaggaca agtgagcgtg     2040

gagattgaat gggagctgca gaaagaaaac agcaaacgct ggaatcccga agtgcagtat     2100

acatctaact atgcaaaatc tgccaacgtt gatttcactg tggacaacaa tggactttat     2160

actgagcctc gccccattgg cacccgttac ctcacccgtc cccngtaa                  2208


<210>  559
<211>  723
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  559

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Val Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Gln Val 
305                 310                 315                 320 


Lys Glu Thr Thr Asp Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Thr Ser Tyr Thr Phe Glu Asp Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr Gln Asn Gln Ser 
        435                 440                 445             


Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser Arg Gly Ser Pro Thr 
    450                 455                 460                 


Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg 
465                 470                 475                 480 


Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn Asn Asn Ser Asn Phe 
                485                 490                 495     


Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn Gly Arg Glu Ser Ile 
            500                 505                 510         


Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys Asp Asp Glu Asp Lys 
        515                 520                 525             


Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly Lys Glu Ser Ala Gly 
    530                 535                 540                 


Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile Thr Asp Glu Glu Ala 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Arg Phe Gly Thr Val Ala Val Asn Leu 
                565                 570                 575     


Gln Ser Ser Pro Ala Thr Asp Val His Ala Met Gly Ala Leu Pro Gly 
            580                 585                 590         


Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala 
        595                 600                 605             


Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly 
    610                 615                 620                 


Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr 
625                 630                 635                 640 


Pro Val Pro Ala Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala 
                645                 650                 655     


Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu 
            660                 665                 670         


Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln 
        675                 680                 685             


Tyr Thr Ser Asn Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp 
    690                 695                 700                 


Asn Asn Gly Leu Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu 
705                 710                 715                 720 


Thr Arg Pro 
            


<210>  560
<211>  2208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  560
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctatgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggtc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaagttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggtaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacagacgct ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca agtgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga agttcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  561
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  561

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Lys Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asp Ala Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Ser Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  562
<211>  2208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  562
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctatgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcaaac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaagttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcgggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggtaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacagacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca agtgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac gaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga agttcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

acagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  563
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  563

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asn Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Lys Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Arg Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asp Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Ser Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  564
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  564
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt cgacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg actttaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaata actggggatt ccggcccaag agactcagct tcaagctctt caacatccag      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgat     1320

caatacctgt attacctgaa cagaactcaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acggacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcactcaat actccacagg acaagtgagc     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210>  565
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  565

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  566
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  566

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Lys Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asp Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asn Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Ser Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Gln 
                725                 730                 735 


<210>  567
<211>  2208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  567
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctatgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggaacgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaagttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggtaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacagacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cggaaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca agtgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga agttcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atcagtaa                  2208


<210>  568
<211>  2208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  568
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctatgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg atccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaagttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtatgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggtaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacagacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca agtgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga agttcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  569
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  569

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Lys Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asp Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Ser Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  570
<211>  18
<212>  DNA
<213>  Unknown

<220>
<223>  Description of unknown: Recognition Site

<400>  570
tagggataac agggtaat                                                     18


<210>  571
<211>  1388
<212>  PRT
<213>  Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9)

<400>  571

Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Thr Thr Asp Asn Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Ser Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Val Leu Leu Phe Asp Ser Gly Ile Thr Ala Glu Gly Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Thr Glu Met Ala Thr Leu Asp Asp Ala 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Pro Asp Asp Lys Arg 
            100                 105                 110         


Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val Glu Glu Lys Ala Tyr 
        115                 120                 125             


His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Ser Thr Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Phe Asn Ser 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Asn Phe Gln Asp Phe Leu Asp Thr Tyr 
            180                 185                 190         


Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu Asn Ser Lys Gln Leu 
        195                 200                 205             


Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Leu Glu Lys Lys Asp Arg 
    210                 215                 220                 


Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser Gly Ile Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Arg Lys Cys Phe 
                245                 250                 255     


Asn Leu Asp Glu Lys Ala Ser Leu His Phe Ser Lys Glu Ser Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Thr Leu Leu Gly Tyr Ile Gly Asp Asp Tyr Ser Asp 
        275                 280                 285             


Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Phe Leu Thr Val Thr Asp Asn Glu Thr Glu Ala Pro Leu Ser Ser Ala 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asn Glu His Lys Glu Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Glu Tyr Ile Arg Asn Ile Ser Leu Lys Thr Tyr Asn Glu Val Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Asp Phe Tyr Val Tyr Leu Lys Lys Leu Leu Ala Glu Phe Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Leu Asp Lys Gln Ala Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala Trp 
    450                 455                 460                 


Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro Trp Asn Phe Glu Asp 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu Leu Thr Lys Val Arg 
        515                 520                 525             


Phe Ile Ala Glu Ser Met Arg Asp Tyr Gln Phe Leu Asp Ser Lys Gln 
    530                 535                 540                 


Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp Lys Arg Lys Val Thr 
545                 550                 555                 560 


Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile Tyr Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ser Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys Glu Phe Leu Asp Asp 
        595                 600                 605             


Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ser Lys Phe Glu Asn 
625                 630                 635                 640 


Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Glu 
            660                 665                 670         


Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ile Ser 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ala Leu Ser Phe Lys 
    690                 695                 700                 


Lys Lys Ile Gln Lys Ala Gln Ile Ile Gly Asp Glu Asp Lys Gly Asn 
705                 710                 715                 720 


Ile Lys Glu Val Val Lys Ser Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly Gly Arg Lys Pro Glu Ser Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Tyr Thr Asn Gln Gly Lys Ser Asn Ser Gln Gln Arg Leu Lys Arg 
    770                 775                 780                 


Leu Glu Lys Ser Leu Lys Glu Leu Gly Ser Lys Ile Leu Lys Glu Asn 
785                 790                 795                 800 


Ile Pro Ala Lys Leu Ser Lys Ile Asp Asn Asn Ala Leu Gln Asn Asp 
                805                 810                 815     


Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly 
            820                 825                 830         


Asp Asp Leu Asp Ile Asp Arg Leu Ser Asn Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Gln Ala Phe Leu Lys Asp Asn Ser Ile Asp Asn Lys Val Leu 
    850                 855                 860                 


Val Ser Ser Ala Ser Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu 
865                 870                 875                 880 


Glu Val Val Lys Lys Arg Lys Thr Phe Trp Tyr Gln Leu Leu Lys Ser 
                885                 890                 895     


Lys Leu Ile Ser Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Ser Pro Glu Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Leu Leu Asp Glu 
    930                 935                 940                 


Lys Phe Asn Asn Lys Lys Asp Glu Asn Asn Arg Ala Val Arg Thr Val 
945                 950                 955                 960 


Lys Ile Ile Thr Leu Lys Ser Thr Leu Val Ser Gln Phe Arg Lys Asp 
                965                 970                 975     


Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn Asp Phe His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Val  Ala Ser Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly Asp Tyr  Pro Lys Tyr 
    1010                 1015                 1020             


Asn Ser  Phe Arg Glu Arg Lys  Ser Ala Thr Glu Lys  Val Tyr Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Ile  Phe Lys Lys Ser Ile  Ser Leu Ala 
    1040                 1045                 1050             


Asp Gly  Arg Val Ile Glu Arg  Pro Leu Ile Glu Val  Asn Glu Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ser Val Trp Asn  Lys Glu Ser Asp Leu  Ala Thr Val 
    1070                 1075                 1080             


Arg Arg  Val Leu Ser Tyr Pro  Gln Val Asn Val Val  Lys Lys Val 
    1085                 1090                 1095             


Glu Glu  Gln Asn His Gly Leu  Asp Arg Gly Lys Pro  Lys Gly Leu 
    1100                 1105                 1110             


Phe Asn  Ala Asn Leu Ser Ser  Lys Pro Lys Pro Asn  Ser Asn Glu 
    1115                 1120                 1125             


Asn Leu  Val Gly Ala Lys Glu  Tyr Leu Asp Pro Lys  Lys Tyr Gly 
    1130                 1135                 1140             


Gly Tyr  Ala Gly Ile Ser Asn  Ser Phe Thr Val Leu  Val Lys Gly 
    1145                 1150                 1155             


Thr Ile  Glu Lys Gly Ala Lys  Lys Lys Ile Thr Asn  Val Leu Glu 
    1160                 1165                 1170             


Phe Gln  Gly Ile Ser Ile Leu  Asp Arg Ile Asn Tyr  Arg Lys Asp 
    1175                 1180                 1185             


Lys Leu  Asn Phe Leu Leu Glu  Lys Gly Tyr Lys Asp  Ile Glu Leu 
    1190                 1195                 1200             


Ile Ile  Glu Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Ser Asp Gly 
    1205                 1210                 1215             


Ser Arg  Arg Met Leu Ala Ser  Ile Leu Ser Thr Asn  Asn Lys Arg 
    1220                 1225                 1230             


Gly Glu  Ile His Lys Gly Asn  Gln Ile Phe Leu Ser  Gln Lys Phe 
    1235                 1240                 1245             


Val Lys  Leu Leu Tyr His Ala  Lys Arg Ile Ser Asn  Thr Ile Asn 
    1250                 1255                 1260             


Glu Asn  His Arg Lys Tyr Val  Glu Asn His Lys Lys  Glu Phe Glu 
    1265                 1270                 1275             


Glu Leu  Phe Tyr Tyr Ile Leu  Glu Phe Asn Glu Asn  Tyr Val Gly 
    1280                 1285                 1290             


Ala Lys  Lys Asn Gly Lys Leu  Leu Asn Ser Ala Phe  Gln Ser Trp 
    1295                 1300                 1305             


Gln Asn  His Ser Ile Asp Glu  Leu Cys Ser Ser Phe  Ile Gly Pro 
    1310                 1315                 1320             


Thr Gly  Ser Glu Arg Lys Gly  Leu Phe Glu Leu Thr  Ser Arg Gly 
    1325                 1330                 1335             


Ser Ala  Ala Asp Phe Glu Phe  Leu Gly Val Lys Ile  Pro Arg Tyr 
    1340                 1345                 1350             


Arg Asp  Tyr Thr Pro Ser Ser  Leu Leu Lys Asp Ala  Thr Leu Ile 
    1355                 1360                 1365             


His Gln  Ser Val Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ala 
    1370                 1375                 1380             


Lys Leu  Gly Glu Gly 
    1385             


<210>  572
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes serotype M1

<400>  572

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  573
<211>  1409
<212>  PRT
<213>  Streptococcus thermophilus

<400>  573

Met Leu Phe Asn Lys Cys Ile Ile Ile Ser Ile Asn Leu Asp Phe Ser 
1               5                   10                  15      


Asn Lys Glu Lys Cys Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile 
            20                  25                  30          


Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Asn Tyr Lys Val 
        35                  40                  45              


Pro Ser Lys Lys Met Lys Val Leu Gly Asn Thr Ser Lys Lys Tyr Ile 
    50                  55                  60                  


Lys Lys Asn Leu Leu Gly Val Leu Leu Phe Asp Ser Gly Ile Thr Ala 
65                  70                  75                  80  


Glu Gly Arg Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg 
                85                  90                  95      


Arg Asn Arg Ile Leu Tyr Leu Gln Glu Ile Phe Ser Thr Glu Met Ala 
            100                 105                 110         


Thr Leu Asp Asp Ala Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val 
        115                 120                 125             


Pro Asp Asp Lys Arg Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val 
    130                 135                 140                 


Glu Glu Lys Val Tyr His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg 
145                 150                 155                 160 


Lys Tyr Leu Ala Asp Ser Thr Lys Lys Ala Asp Leu Arg Leu Val Tyr 
                165                 170                 175     


Leu Ala Leu Ala His Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu 
            180                 185                 190         


Gly Glu Phe Asn Ser Lys Asn Asn Asp Ile Gln Lys Asn Phe Gln Asp 
        195                 200                 205             


Phe Leu Asp Thr Tyr Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu 
    210                 215                 220                 


Asn Ser Lys Gln Leu Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Leu 
225                 230                 235                 240 


Glu Lys Lys Asp Arg Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser 
                245                 250                 255     


Gly Ile Phe Ser Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp 
            260                 265                 270         


Phe Arg Lys Cys Phe Asn Leu Asp Glu Lys Ala Ser Leu His Phe Ser 
        275                 280                 285             


Lys Glu Ser Tyr Asp Glu Asp Leu Glu Thr Leu Leu Gly Tyr Ile Gly 
    290                 295                 300                 


Asp Asp Tyr Ser Asp Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala 
305                 310                 315                 320 


Ile Leu Leu Ser Gly Phe Leu Thr Val Thr Asp Asn Glu Thr Glu Ala 
                325                 330                 335     


Pro Leu Ser Ser Ala Met Ile Lys Arg Tyr Asn Glu His Lys Glu Asp 
            340                 345                 350         


Leu Ala Leu Leu Lys Glu Tyr Ile Arg Asn Ile Ser Leu Lys Thr Tyr 
        355                 360                 365             


Asn Glu Val Phe Lys Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Ile 
    370                 375                 380                 


Asp Gly Lys Thr Asn Gln Glu Asp Phe Tyr Val Tyr Leu Lys Asn Leu 
385                 390                 395                 400 


Leu Ala Glu Phe Glu Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg 
                405                 410                 415     


Glu Asp Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro 
            420                 425                 430         


Tyr Gln Ile His Leu Gln Glu Met Arg Ala Ile Leu Asp Lys Gln Ala 
        435                 440                 445             


Lys Phe Tyr Pro Phe Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile 
    450                 455                 460                 


Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn 
465                 470                 475                 480 


Ser Asp Phe Ala Trp Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro 
                485                 490                 495     


Trp Asn Phe Glu Asp Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe 
            500                 505                 510         


Ile Asn Arg Met Thr Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val 
        515                 520                 525             


Leu Pro Lys His Ser Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu 
    530                 535                 540                 


Leu Thr Lys Val Arg Phe Ile Ala Glu Ser Met Arg Asp Tyr Gln Phe 
545                 550                 555                 560 


Leu Asp Ser Lys Gln Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp 
                565                 570                 575     


Lys Arg Lys Val Thr Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile 
            580                 585                 590         


Tyr Gly Tyr Asp Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn 
        595                 600                 605             


Ser Ser Leu Ser Thr Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys 
    610                 615                 620                 


Glu Phe Leu Asp Asp Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile 
625                 630                 635                 640 


His Thr Leu Thr Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu 
                645                 650                 655     


Ser Lys Phe Glu Asn Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser 
            660                 665                 670         


Arg Arg His Tyr Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn 
        675                 680                 685             


Gly Ile Arg Asp Glu Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile 
    690                 695                 700                 


Asp Asp Gly Ile Ser Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
705                 710                 715                 720 


Ala Leu Ser Phe Lys Lys Lys Ile Gln Lys Ala Gln Ile Ile Gly Asp 
                725                 730                 735     


Glu Asp Lys Gly Asn Ile Lys Glu Val Val Lys Ser Leu Pro Gly Ser 
            740                 745                 750         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu 
        755                 760                 765             


Leu Val Lys Val Met Gly Gly Arg Lys Pro Glu Ser Ile Val Val Glu 
    770                 775                 780                 


Met Ala Arg Glu Asn Gln Tyr Thr Asn Gln Gly Lys Ser Asn Ser Gln 
785                 790                 795                 800 


Gln Arg Leu Lys Arg Leu Glu Lys Ser Leu Lys Glu Leu Gly Ser Lys 
                805                 810                 815     


Ile Leu Lys Glu Asn Ile Pro Ala Lys Leu Ser Lys Ile Asp Asn Asn 
            820                 825                 830         


Ala Leu Gln Asn Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys 
        835                 840                 845             


Asp Met Tyr Thr Gly Asp Asp Leu Asp Ile Asp Arg Leu Ser Asn Tyr 
    850                 855                 860                 


Asp Ile Asp His Ile Ile Pro Gln Ala Phe Leu Lys Asp Asn Ser Ile 
865                 870                 875                 880 


Asp Asn Lys Val Leu Val Ser Ser Ala Ser Asn Arg Gly Lys Ser Asp 
                885                 890                 895     


Asp Phe Pro Ser Leu Glu Val Val Lys Lys Arg Lys Thr Phe Trp Tyr 
            900                 905                 910         


Gln Leu Leu Lys Ser Lys Leu Ile Ser Gln Arg Lys Phe Asp Asn Leu 
        915                 920                 925             


Thr Lys Ala Glu Arg Gly Gly Leu Leu Pro Glu Asp Lys Ala Gly Phe 
    930                 935                 940                 


Ile Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala 
945                 950                 955                 960 


Arg Leu Leu Asp Glu Lys Phe Asn Asn Lys Lys Asp Glu Asn Asn Arg 
                965                 970                 975     


Ala Val Arg Thr Val Lys Ile Ile Thr Leu Lys Ser Thr Leu Val Ser 
            980                 985                 990         


Gln Phe Arg Lys Asp Phe Glu Leu  Tyr Lys Val Arg Glu  Ile Asn Asp 
        995                 1000                 1005             


Phe His  His Ala His Asp Ala  Tyr Leu Asn Ala Val  Ile Ala Ser 
    1010                 1015                 1020             


Ala Leu  Leu Lys Lys Tyr Pro  Lys Leu Glu Pro Glu  Phe Val Tyr 
    1025                 1030                 1035             


Gly Asp  Tyr Pro Lys Tyr Asn  Ser Phe Arg Glu Arg  Lys Ser Ala 
    1040                 1045                 1050             


Thr Glu  Lys Val Tyr Phe Tyr  Ser Asn Ile Met Asn  Ile Phe Lys 
    1055                 1060                 1065             


Lys Ser  Ile Ser Leu Ala Asp  Gly Arg Val Ile Glu  Arg Pro Leu 
    1070                 1075                 1080             


Ile Glu  Val Asn Glu Glu Thr  Gly Glu Ser Val Trp  Asn Lys Glu 
    1085                 1090                 1095             


Ser Asp  Leu Ala Thr Val Arg  Arg Val Leu Ser Tyr  Pro Gln Val 
    1100                 1105                 1110             


Asn Val  Val Lys Lys Val Glu  Glu Gln Asn His Gly  Leu Asp Arg 
    1115                 1120                 1125             


Gly Lys  Pro Lys Gly Leu Phe  Asn Ala Asn Leu Ser  Ser Lys Pro 
    1130                 1135                 1140             


Lys Pro  Asn Ser Asn Glu Asn  Leu Val Gly Ala Lys  Glu Tyr Leu 
    1145                 1150                 1155             


Asp Pro  Lys Lys Tyr Gly Gly  Tyr Ala Gly Ile Ser  Asn Ser Phe 
    1160                 1165                 1170             


Ala Val  Leu Val Lys Gly Thr  Ile Glu Lys Gly Ala  Lys Lys Lys 
    1175                 1180                 1185             


Ile Thr  Asn Val Leu Glu Phe  Gln Gly Ile Ser Ile  Leu Asp Arg 
    1190                 1195                 1200             


Ile Asn  Tyr Arg Lys Asp Lys  Leu Asn Phe Leu Leu  Glu Lys Gly 
    1205                 1210                 1215             


Tyr Lys  Asp Ile Glu Leu Ile  Ile Glu Leu Pro Lys  Tyr Ser Leu 
    1220                 1225                 1230             


Phe Glu  Leu Ser Asp Gly Ser  Arg Arg Met Leu Ala  Ser Ile Leu 
    1235                 1240                 1245             


Ser Thr  Asn Asn Lys Arg Gly  Glu Ile His Lys Gly  Asn Gln Ile 
    1250                 1255                 1260             


Phe Leu  Ser Gln Lys Phe Val  Lys Leu Leu Tyr His  Ala Lys Arg 
    1265                 1270                 1275             


Ile Ser  Asn Thr Ile Asn Glu  Asn His Arg Lys Tyr  Val Glu Asn 
    1280                 1285                 1290             


His Lys  Lys Glu Phe Glu Glu  Leu Phe Tyr Tyr Ile  Leu Glu Phe 
    1295                 1300                 1305             


Asn Glu  Asn Tyr Val Gly Ala  Lys Lys Asn Gly Lys  Leu Leu Asn 
    1310                 1315                 1320             


Ser Ala  Phe Gln Ser Trp Gln  Asn His Ser Ile Asp  Glu Leu Cys 
    1325                 1330                 1335             


Ser Ser  Phe Ile Gly Pro Thr  Gly Ser Glu Arg Lys  Gly Leu Phe 
    1340                 1345                 1350             


Glu Leu  Thr Ser Arg Gly Ser  Ala Ala Asp Phe Glu  Phe Leu Gly 
    1355                 1360                 1365             


Val Lys  Ile Pro Arg Tyr Arg  Asp Tyr Thr Pro Ser  Ser Leu Leu 
    1370                 1375                 1380             


Lys Asp  Ala Thr Leu Ile His  Gln Ser Val Thr Gly  Leu Tyr Glu 
    1385                 1390                 1395             


Thr Arg  Ile Asp Leu Ala Lys  Leu Gly Glu Gly 
    1400                 1405                 


<210>  574
<211>  1370
<212>  PRT
<213>  Streptococcus ratti FA-1 = DSM 20564

<400>  574

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Asn Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Leu Leu 
65                  70                  75                  80  


Tyr Leu Gln Asp Ile Phe Ser Asp Glu Met Asn Lys Val Asp Glu Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Ser Glu Asp Lys Arg 
            100                 105                 110         


Gly Asp His His Pro Ile Phe Gly Asn Val Val Asp Glu Val Lys Tyr 
        115                 120                 125             


His Glu Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Thr Pro Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Asp Asp Pro Lys Leu Asp 
                165                 170                 175     


Val Lys Asn Thr Asp Ser Gln Glu Leu Phe Ser Gln Phe Leu Thr Ala 
            180                 185                 190         


Tyr Asp Val Thr Gln Glu Asp Ser His Leu Ala Asp Val Lys Ile Asn 
        195                 200                 205             


Ile Ser Asp Ile Ile Thr Glu Lys Met Asn Lys Ser Arg Lys Val Glu 
    210                 215                 220                 


Ala Leu Leu Phe His Phe Pro Ser Gln Lys Lys Asn Ser Phe Phe Gly 
225                 230                 235                 240 


Asn Leu Val Ser Leu Val Phe Gly Leu Leu Pro Asn Phe Lys Thr Asn 
                245                 250                 255     


Phe Asn Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Tyr Thr 
        275                 280                 285             


Asp Val Phe Val Ala Ala Arg Lys Leu Tyr Asp Ser Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Asn Asp Leu Ser Thr Lys Ala Ile Leu Ser Ala 
305                 310                 315                 320 


Ser Met Val Arg Arg Tyr Glu Glu His Asn Lys Asp Leu Ala Lys Leu 
                325                 330                 335     


Lys Ala Phe Val Lys Ala Asn Phe Thr His Asp Val Phe Lys Glu Val 
            340                 345                 350         


Phe Ser Asp Ala Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Gly Lys 
        355                 360                 365             


Thr Ser Gln Glu Asp Phe Tyr Lys Tyr Val Lys Asn Leu Ile Gly Lys 
    370                 375                 380                 


Val Asp Gly Ser Ala Asp Phe Ile Glu Lys Ile Asp Arg Glu Asp Phe 
385                 390                 395                 400 


Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val 
                405                 410                 415     


His Leu Ala Glu Met Lys Ala Ile Leu Arg Arg Gln Gly Glu Tyr Tyr 
            420                 425                 430         


Pro Phe Leu Lys Glu His Ala Glu Lys Ile Gln Gln Ile Leu Thr Phe 
        435                 440                 445             


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asp Arg His Gly His Ser Asp 
    450                 455                 460                 


Phe Ala Trp Ala Ser Phe Asn Ser Glu Glu Lys Val Thr Pro Trp Asn 
465                 470                 475                 480 


Phe Glu Glu Ile Ile Asp Lys Asn Lys Ser Ala Gln Ala Phe Ile Glu 
                485                 490                 495     


Arg Met Thr Asn Gln Asp Leu Tyr Leu Pro Asn Glu Lys Val Leu Pro 
            500                 505                 510         


Lys His Ser Pro Leu Tyr Glu Lys Tyr Thr Val Tyr Asn Glu Leu Thr 
        515                 520                 525             


Lys Ile Lys Tyr Val Thr Glu Thr Gly Thr Ala Lys Phe Phe Asp Ala 
    530                 535                 540                 


Asn Leu Lys Gln Glu Ile Phe Asp Gly Leu Phe Lys Lys Glu Arg Lys 
545                 550                 555                 560 


Val Thr Lys Arg Lys Leu Leu Thr Phe Leu Glu Lys Asn Phe Asp Glu 
                565                 570                 575     


Phe Arg Ile Val Asp Ile Gln Gly Leu Asp Lys Glu Thr Glu Thr Phe 
            580                 585                 590         


Asn Ala Ser Tyr Gly Ile Tyr Gln Asp Leu Leu Lys Ile Ile Lys Asp 
        595                 600                 605             


Lys Ala Phe Met Asp Asp Ser Glu Asn Ala Asp Ile Leu Glu Asp Ile 
    610                 615                 620                 


Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Gln Arg 
625                 630                 635                 640 


Leu Ala Lys Tyr Ala Asp Leu Phe Asp Lys Lys Val Ile Asp Asn Leu 
                645                 650                 655     


Ala Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu 
            660                 665                 670         


Asn Gly Ile Arg Asp Lys Arg Ser Arg Lys Thr Ile Met Asp Tyr Leu 
        675                 680                 685             


Val Asp Asp Gly Arg Ser Asn Arg Asn Leu Met Gln Leu Ile Thr Asp 
    690                 695                 700                 


Asp Asn Leu Thr Phe Lys Asp Glu Ile Ala Lys Ala Gln Tyr Ser Asp 
705                 710                 715                 720 


Asn Ser Asp Asp Leu His Gln Val Val Gln Asp Leu Ala Gly Ser Pro 
                725                 730                 735     


Ala Ile Lys Lys Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu 
            740                 745                 750         


Val Lys Val Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala 
        755                 760                 765             


Arg Glu Asn Gln Thr Thr Ala Lys Gly Arg Arg Asn Ser Gln Gln Arg 
    770                 775                 780                 


Tyr Lys Arg Leu Glu Glu Ala Ile Lys Asn Leu Asp Arg Asp Leu Asn 
785                 790                 795                 800 


Tyr Lys Ile Leu Lys Glu His Pro Thr Asp Asn Gln Ala Leu Gln Asn 
                805                 810                 815     


Asp Arg Leu Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr 
            820                 825                 830         


Gly Glu Ser Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Ile Asp His 
        835                 840                 845             


Ile Ile Pro Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg Val 
    850                 855                 860                 


Leu Val Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser 
865                 870                 875                 880 


Glu Asp Val Val Asn Arg Met Arg Pro Phe Trp Asn Lys Leu Leu Asn 
                885                 890                 895     


Cys Gly Leu Ile Ser Gln Arg Lys Tyr Ser Asn Leu Thr Lys Lys Glu 
            900                 905                 910         


Leu Thr Pro Asn Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu His Phe 
    930                 935                 940                 


Asn Lys Glu Phe Asp Glu Asp Lys Lys Arg Ile Arg Lys Val Lys Val 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu 
                965                 970                 975     


Leu Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Leu Leu Met Lys  Tyr Pro Lys 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Glu Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Arg  Glu Arg Lys Thr Ala  Thr Gln Arg Met Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Met Phe Lys  Ser Lys Val Lys Leu  Ala Asp Glu 
    1040                 1045                 1050             


Arg Ile  Ile Glu Arg Pro Met  Ile Glu Val Asn Asp  Glu Thr Gly 
    1055                 1060                 1065             


Glu Ile  Ala Trp Asp Lys Thr  Lys His Ile Ala Thr  Val Lys Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Ile  Asn Ile Val Lys Lys  Val Glu Glu 
    1085                 1090                 1095             


Gln Thr  Gly Gly Leu Thr Asn  Glu Thr Ile Tyr Pro  Arg Gly Ser 
    1100                 1105                 1110             


Phe Asp  Lys Leu Leu Asn Arg  Lys Asn Thr Leu Glu  Ala Ser Lys 
    1115                 1120                 1125             


Tyr Gly  Gly Phe Gly Ser Pro  Thr Val Ala Tyr Cys  Val Leu Val 
    1130                 1135                 1140             


Val Ala  Asp Ser Lys Asn Glu  Asn Gly Lys Val Lys  Lys Leu Lys 
    1145                 1150                 1155             


Leu Gly  Ser Glu Leu Leu Gly  Ile Thr Ile Leu Glu  Lys Asn Asp 
    1160                 1165                 1170             


Phe Glu  Asn Asn Ser Leu Asp  Phe Leu Ser Arg Lys  Gly Tyr Gln 
    1175                 1180                 1185             


Gly Val  Gln Glu Lys Lys Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Phe Gln Asp Gly Ser  Arg Arg Met Leu Ser  Ser Val Met 
    1205                 1210                 1215             


Ala Asn  Asp Asn Lys Arg Gly  Asp Leu Gln Lys Ala  Asn Glu Met 
    1220                 1225                 1230             


Ile Leu  Pro Ala Tyr Leu Val  Lys Leu Leu Tyr His  Ala Lys His 
    1235                 1240                 1245             


Ile Asn  Ser Val Gly Glu Pro  Ala His Lys Asn Tyr  Ile Asn Glu 
    1250                 1255                 1260             


His Cys  Ser Glu Phe Gln Asp  Leu Leu Asn Tyr Ile  Arg Gln Phe 
    1265                 1270                 1275             


Ala Asp  Lys Phe Val Asp Val  Asp Lys Asn Leu Ser  Lys Ile Arg 
    1280                 1285                 1290             


Ser Leu  Ser Lys Ser Met Ala  Glu Tyr Ser Val Ser  Glu Ile Cys 
    1295                 1300                 1305             


Ser Ser  Phe Val Asn Leu Leu  Thr Leu Thr Ala Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Asp  Phe Lys Phe Phe Gly  Thr Thr Ile Pro Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Gly Ser  Pro Gln Ser Ile Leu  Ser Ala Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  575
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae ZQ0910

<400>  575

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  576
<211>  1371
<212>  PRT
<213>  Streptococcus dysgalactiae subsp. equisimilis AC-2713

<400>  576

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Ser Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Met Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Glu Phe Leu Ser Gly Lys Gln 
    530                 535                 540                 


Lys Glu Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Lys Tyr Ala 
625                 630                 635                 640 


Asn Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Ala Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Glu Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Ala Leu Thr  Asn Glu Ser Ile Tyr  Ala Arg Gly 
    1100                 1105                 1110             


Ser Phe  Asp Lys Leu Ile Ser  Arg Lys His Arg Phe  Glu Ser Ser 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Gly Ser  Pro Thr Val Thr Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Ser Lys Val  Gln Asp Gly Lys Val  Lys Lys Ile 
    1145                 1150                 1155             


Lys Thr  Gly Lys Glu Leu Ile  Gly Ile Thr Leu Leu  Asp Lys Leu 
    1160                 1165                 1170             


Val Phe  Glu Lys Asn Pro Leu  Lys Phe Ile Glu Asp  Lys Gly Tyr 
    1175                 1180                 1185             


Gly Asn  Val Gln Ile Asp Lys  Cys Ile Lys Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Phe Glu Asn Gly  Thr Arg Arg Met Leu  Ala Ser Val 
    1205                 1210                 1215             


Met Ala  Asn Asn Asn Ser Arg  Gly Asp Leu Gln Lys  Ala Asn Glu 
    1220                 1225                 1230             


Met Phe  Leu Pro Ala Lys Leu  Val Thr Leu Leu Tyr  His Ala His 
    1235                 1240                 1245             


Lys Ile  Glu Ser Ser Lys Glu  Leu Glu His Glu Ala  Tyr Ile Leu 
    1250                 1255                 1260             


Asp His  Tyr Asn Asp Leu Tyr  Gln Leu Leu Ser Tyr  Ile Glu Arg 
    1265                 1270                 1275             


Phe Ala  Ser Leu Tyr Val Asp  Val Glu Lys Asn Ile  Ser Lys Val 
    1280                 1285                 1290             


Lys Glu  Leu Phe Ser Asn Ile  Glu Ser Tyr Ser Ile  Ser Glu Ile 
    1295                 1300                 1305             


Cys Ser  Ser Val Ile Asn Leu  Leu Thr Leu Thr Ala  Ser Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Lys Phe Leu  Gly Thr Thr Ile Pro  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Gly  Ser Pro Gln Ser Ile  Leu Ser Ser Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1355                 1360                 1365             


Gly Gly  Asp 
    1370     


<210>  577
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae H36B


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa = any amino acid

<400>  577

Met Asn Lys Pro Tyr Ser Ile Gly Xaa Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  578
<211>  1345
<212>  PRT
<213>  Streptococcus mutans A19

<400>  578

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Ile  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  579
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae CJB111


<220>
<221>  MOD_RES
<222>  (117)..(117)
<223>  Xaa = any amino acid

<400>  579

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Xaa Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  580
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae LADL-90-503

<400>  580

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Ser Phe Glu Asn Asn His Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Tyr Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Val 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Gln Leu Leu Asp Phe Leu Ala Lys Glu Phe Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Ile Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Arg Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Ser Asp 
        675                 680                 685             


Gly Arg Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ser Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Glu Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asp Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile Asp Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Ala Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Ile Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Pro Asp Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Lys Val Asp Asp Asn Asn Lys Pro Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Glu 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Glu Thr Gly 
    1055                 1060                 1065             


Glu Ile  Ala Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Ser Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Leu Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Lys Glu Leu Ile  Gly Ile Thr Ile Met  Glu Arg Glu 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Thr Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Tyr 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Ile Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Ser Asp Asn Lys Asp  Asn Thr Pro Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Lys Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ser Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asp Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  581
<211>  1345
<212>  PRT
<213>  Streptococcus mutans ATCC 25175

<400>  581

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  582
<211>  1350
<212>  PRT
<213>  Streptococcus mutans KK23

<400>  582

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Thr Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Gln Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val Val Asn Arg Met Arg 
865                 870                 875                 880 


Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu Ile Ser Gln Arg Lys 
                885                 890                 895     


Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Leu Asp Asp Lys Ala Gly 
            900                 905                 910         


Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val 
        915                 920                 925             


Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu Phe Asp Asp Asn Asn 
    930                 935                 940                 


Lys Arg Ile Cys Lys Val Lys Ile Val Thr Leu Lys Ser Asn Leu Val 
945                 950                 955                 960 


Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn 
                965                 970                 975     


Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Val Lys 
            980                 985                 990         


Ala Leu Leu Val Lys Tyr Ser Lys  Leu Glu Pro Glu Phe  Val Tyr Gly 
        995                 1000                 1005             


Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu Arg Lys  Thr Ala Thr 
    1010                 1015                 1020             


Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met Asn Met  Phe Lys Ser 
    1025                 1030                 1035             


Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val Glu Arg  Pro Met Ile 
    1040                 1045                 1050             


Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala Trp Asp  Lys Thr Lys 
    1055                 1060                 1065             


His Ile  Thr Thr Val Lys Lys  Val Leu Ser Tyr Pro  Gln Val Asn 
    1070                 1075                 1080             


Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile Gly Gln  Asn Gly Gly 
    1085                 1090                 1095             


Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu Glu Val  Ile Pro Ser 
    1100                 1105                 1110             


Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn Pro Glu  Lys Tyr Gly 
    1115                 1120                 1125             


Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro Ile Leu  Leu Ile Val 
    1130                 1135                 1140             


Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val Met Asp  Lys Lys Arg 
    1145                 1150                 1155             


Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys Asp Lys  Gly Tyr Gln 
    1160                 1165                 1170             


Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu Pro Lys  Tyr Thr Leu 
    1175                 1180                 1185             


Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu Trp Ala  Ser Ser Lys 
    1190                 1195                 1200             


Glu Val  His Lys Gly Asn Gln  Leu Val Val Ser Lys  Lys Ser Gln 
    1205                 1210                 1215             


Asp Leu  Leu Tyr His Ala His  His Leu Asp Asn Asp  Tyr Ser Asn 
    1220                 1225                 1230             


Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe Asp Ile  Leu Phe Asn 
    1235                 1240                 1245             


Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys Leu Gly  Lys Glu His 
    1250                 1255                 1260             


Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys Glu Arg  Asp Ser Ala 
    1265                 1270                 1275             


Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile Lys Leu  Leu Gly Phe 
    1280                 1285                 1290             


Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser Phe Leu  Gly Ile Lys 
    1295                 1300                 1305             


Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys Asp Tyr  Leu Leu Pro 
    1310                 1315                 1320             


Cys Met  Glu Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1325                 1330                 1335             


Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345                 1350 


<210>  583
<211>  1345
<212>  PRT
<213>  Streptococcus mutans S1B

<400>  583

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 
            100                 105                 110         


Phe Asp Ser Tyr Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Arg Asn 
225                 230                 235                 240 


Leu Val Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Ala Glu His His Glu Asp Leu Glu Lys Leu Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Asn Lys Pro Glu Leu Tyr His Asp Ile Phe Lys 
            340                 345                 350         


Asp Glu Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile Ala 
    370                 375                 380                 


Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Gly Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  584
<211>  1371
<212>  PRT
<213>  Streptococcus oralis SK610

<400>  584

Met Glu Asn Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ser Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Arg Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Ala Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Ile Pro Glu Asp Lys 
            100                 105                 110         


Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Ala Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Asp Thr Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Ser Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 
    210                 215                 220                 


Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Gly Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Val Leu 
                325                 330                 335     


Lys Gln Phe Ile Lys Asn Asn Leu Pro Glu Lys Tyr Asp Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Glu Gly Thr Asp Tyr Phe Leu Glu Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Lys Asp Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Glu Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Asp Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly 
    530                 535                 540                 


Gln Lys Lys Gln Ile Val Thr Gln Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Gln Phe Leu His Asn Val Asp Gly Tyr Asp 
                565                 570                 575     


Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Met Asp 
        595                 600                 605             


Asp Ser Lys Asn Glu Glu Ile Leu Glu Asn Ile Val His Thr Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asp 
625                 630                 635                 640 


Ser Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Ile Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asp Gly Ile Cys Asp 
            660                 665                 670         


Lys Gln Thr Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Lys 
        675                 680                 685             


Asn Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe 
    690                 695                 700                 


Lys Glu Ile Thr Gln Lys Ala Gln Val Val Gly Lys Thr Asp Asp Val 
705                 710                 715                 720 


Lys Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Thr Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu 
    770                 775                 780                 


Asp Ala Leu Lys Asn Leu Ala Ser Gly Leu Asp Ser Asn Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asn Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Lys Pro Leu Asp 
            820                 825                 830         


Ile Asn Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Val Pro Gln Ala 
        835                 840                 845             


Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Leu Lys 
    850                 855                 860                 


Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Glu Val Val Gln 
865                 870                 875                 880 


Lys Arg Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser 
                885                 890                 895     


Glu Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asp 
            900                 905                 910         


Glu Arg Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala Arg Phe Asn Lys 
    930                 935                 940                 


Glu Val Asn Glu Lys Asp Lys Lys Asn Arg Thr Val Lys Ile Ile Thr 
945                 950                 955                 960 


Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Arg Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Ala Val Val Ala Lys Ala Ile  Leu Lys Lys Tyr Pro  Lys Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Asp  Tyr Gln Lys Tyr Asp  Leu Lys Arg 
    1010                 1015                 1020             


Tyr Ile  Ser Arg Ser Arg Asn  Pro Lys Glu Val Glu  Lys Ala Thr 
    1025                 1030                 1035             


Glu Lys  Tyr Phe Phe Tyr Ser  Asn Leu Leu Asn Phe  Phe Lys Glu 
    1040                 1045                 1050             


Glu Val  His Tyr Ala Asp Gly  Thr Ile Val Lys Arg  Glu Asn Ile 
    1055                 1060                 1065             


Glu Tyr  Ser Lys Asp Thr Gly  Glu Ile Ala Trp Asn  Lys Glu Lys 
    1070                 1075                 1080             


Asp Phe  Ala Thr Ile Lys Lys  Val Leu Ser Tyr Pro  Gln Val Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Arg Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1100                 1105                 1110             


Ser Ile  Leu Pro Lys Gly Asn  Ser Asp Lys Leu Ile  Pro Arg Lys 
    1115                 1120                 1125             


Thr Lys  Asp Ile Leu Trp Glu  Thr Thr Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Val Ile Ala Tyr Ser  Ile Leu Leu Ile Ala  Asp Ile Glu 
    1145                 1150                 1155             


Lys Gly  Lys Ala Lys Lys Leu  Lys Thr Val Lys Thr  Leu Val Gly 
    1160                 1165                 1170             


Ile Thr  Ile Met Glu Lys Ala  Ala Phe Glu Glu Asn  Pro Ile Thr 
    1175                 1180                 1185             


Phe Leu  Glu Asn Lys Gly Tyr  His Asn Val Arg Lys  Glu Asn Ile 
    1190                 1195                 1200             


Leu Cys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1205                 1210                 1215             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Leu Gln Lys  Gly Asn Glu 
    1220                 1225                 1230             


Ile Val  Leu Pro Val Tyr Leu  Thr Thr Leu Leu Tyr  His Ser Lys 
    1235                 1240                 1245             


Asn Val  His Lys Leu Asp Glu  Pro Glu His Leu Glu  Tyr Ile Gln 
    1250                 1255                 1260             


Lys His  Arg Asn Glu Phe Lys  Asp Leu Leu Asn Leu  Val Ser Glu 
    1265                 1270                 1275             


Phe Ser  Gln Lys Tyr Val Leu  Ala Asp Ala Asn Leu  Glu Lys Ile 
    1280                 1285                 1290             


Gln Asn  Leu Tyr Ala Asp Asn  Glu Gln Ala Asp Ile  Glu Ile Leu 
    1295                 1300                 1305             


Ala Asn  Ser Phe Ile Asn Leu  Leu Thr Phe Thr Ala  Leu Gly Ala 
    1310                 1315                 1320             


Pro Ala  Ala Phe Lys Phe Phe  Gly Lys Asp Ile Asp  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Thr  Thr Val Ser Glu Ile  Leu Asn Ala Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu 
    1355                 1360                 1365             


Gly Glu  Asp 
    1370     


<210>  585
<211>  1377
<212>  PRT
<213>  Streptococcus agalactiae 515

<400>  585

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Tyr Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Val Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His His Glu Asp Leu Lys His Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Asn Tyr Arg Glu Val Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Leu Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Arg Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Phe Leu Ala Glu Gly Phe Lys Asp Phe Gln Phe Leu Asn Arg Lys 
    530                 535                 540                 


Gln Lys Glu Thr Ile Phe Asn Ser Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Ser Phe Leu Asn Lys Val Asp Gly Tyr Glu 
                565                 570                 575     


Gly Ile Ala Ile Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Lys Lys Ile Leu Gly Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Thr Asp Asn Glu Leu Ile Leu Glu Asp Ile Val Gln Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Lys Cys Leu Asp Ile Tyr Lys Asp 
625                 630                 635                 640 


Phe Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asn Lys 
            660                 665                 670         


Glu Asn Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ser Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Asp Leu Ser Phe Lys 
    690                 695                 700                 


Pro Ile Ile Asp Lys Ala Arg Thr Gly Ser His Ser Asp Asn Leu Lys 
705                 710                 715                 720 


Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 
            740                 745                 750         


Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Leu Ser Arg Ser Arg Gln Arg Leu Thr Thr Leu Arg Glu 
    770                 775                 780                 


Ser Leu Ala Asn Leu Lys Ser Asn Ile Leu Glu Glu Lys Lys Pro Lys 
785                 790                 795                 800 


Tyr Val Lys Asp Gln Val Glu Asn His His Leu Ser Asp Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Lys Lys Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile Glu Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Met Phe Trp Lys Asn Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Val Asp Asn Gly Lys Lys Ile Cys Lys Val Lys Ile Val 
945                 950                 955                 960 


Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly Phe 
                965                 970                 975     


Tyr Lys Ile Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr 
            980                 985                 990         


Leu Asn Ala Val Val Ala Lys Ala  Ile Leu Thr Lys Tyr  Pro Gln Leu 
        995                 1000                 1005             


Glu Pro  Glu Phe Val Tyr Gly  Met Tyr Arg Gln Lys  Lys Leu Ser 
    1010                 1015                 1020             


Lys Ile  Val His Glu Asp Lys  Glu Glu Lys Tyr Ser  Glu Ala Thr 
    1025                 1030                 1035             


Arg Lys  Met Phe Phe Tyr Ser  Asn Leu Met Asn Met  Phe Lys Arg 
    1040                 1045                 1050             


Val Val  Arg Leu Ala Asp Gly  Ser Ile Val Val Arg  Pro Val Ile 
    1055                 1060                 1065             


Glu Thr  Gly Arg Tyr Met Gly  Lys Thr Ala Trp Asp  Lys Lys Lys 
    1070                 1075                 1080             


His Phe  Ala Thr Val Arg Lys  Val Leu Ser Tyr Pro  Gln Asn Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Thr Glu Ile  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1100                 1105                 1110             


Ser Ile  Leu Ala His Gly Asn  Ser Asp Lys Leu Ile  Pro Arg Lys 
    1115                 1120                 1125             


Thr Lys  Asp Ile Tyr Leu Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Ile Val Ala Tyr Ser  Val Leu Val Val Ala  Asp Ile Lys 
    1145                 1150                 1155             


Lys Gly  Lys Ala Gln Lys Leu  Lys Thr Val Thr Glu  Leu Leu Gly 
    1160                 1165                 1170             


Ile Thr  Ile Met Glu Arg Ser  Arg Phe Glu Lys Asn  Pro Ser Ala 
    1175                 1180                 1185             


Phe Leu  Glu Ser Lys Gly Tyr  Leu Asn Ile Arg Asp  Asp Lys Leu 
    1190                 1195                 1200             


Met Ile  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1205                 1210                 1215             


Arg Arg  Leu Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1220                 1225                 1230             


Leu Ala  Leu Pro Thr Gln Phe  Met Lys Phe Leu Tyr  Leu Ala Ser 
    1235                 1240                 1245             


Arg Tyr  Asn Glu Ser Lys Gly  Lys Pro Glu Glu Ile  Glu Lys Lys 
    1250                 1255                 1260             


Gln Glu  Phe Val Asn Gln His  Val Ser Tyr Phe Asp  Asp Ile Leu 
    1265                 1270                 1275             


Gln Leu  Ile Asn Asp Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1280                 1285                 1290             


Asn Leu  Glu Lys Ile Asn Lys  Leu Tyr Gln Asp Asn  Lys Glu Asn 
    1295                 1300                 1305             


Ile Pro  Val Asp Glu Leu Ala  Asn Asn Ile Ile Asn  Leu Phe Thr 
    1310                 1315                 1320             


Phe Thr  Ser Leu Gly Ala Pro  Ala Ala Phe Lys Phe  Phe Asp Lys 
    1325                 1330                 1335             


Ile Val  Asp Arg Lys Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asn 
    1340                 1345                 1350             


Ser Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1355                 1360                 1365             


Ile Asp  Leu Gly Lys Leu Gly  Glu Asp 
    1370                 1375         


<210>  586
<211>  1375
<212>  PRT
<213>  Streptococcus sp. M334

<400>  586

Met Ser Asn Lys Ser Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys His Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Asp Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ser Gln Glu Ile Ser Lys Val Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Phe Phe Leu Val Pro Glu Asp Lys 
            100                 105                 110         


Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Val Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ser Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Ser Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asp Asn Thr Phe Glu Gly Lys Ser Leu Ser Gly Gln Asn Ala Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Thr Lys Arg Glu 
    210                 215                 220                 


Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Lys Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Ala Leu 
                325                 330                 335     


Lys Gln Phe Ile Gln Asn Asn Leu Gln Glu Lys Tyr Asp Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Glu Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Lys Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Ile Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Gln Glu Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Gly Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Gln Ala Ser Ser Ala Glu Asp Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Leu Thr Arg Tyr Gln Phe Leu Asp Lys Lys 
    530                 535                 540                 


Gln Lys Lys Asp Ile Phe Asp Thr Phe Phe Lys Ala Glu Asn Lys Arg 
545                 550                 555                 560 


Lys Val Thr Glu Lys Asp Ile Ile His Tyr Leu His Asn Val Asp Gly 
                565                 570                 575     


Tyr Asp Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser 
            580                 585                 590         


Leu Ser Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Ala Phe 
        595                 600                 605             


Met Asp Asp Ser Lys Asn Glu Glu Ile Leu Glu Asn Ile Ile His Thr 
    610                 615                 620                 


Leu Thr Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln 
625                 630                 635                 640 


Tyr Asp Ser Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Lys Ser Gly Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Glu Ile Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Glu Ile Ile Gln Lys Ala Gln Val Phe Gly Lys Thr Asn 
705                 710                 715                 720 


Asp Val Lys Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly His Ala Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg 
    770                 775                 780                 


Ile Glu Asp Ser Leu Lys Asn Leu Ala Ser Gly Leu Asp Ser Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Asn Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Lys Pro 
            820                 825                 830         


Leu Glu Ile Asn Gln Leu Ser Asn Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser 
    850                 855                 860                 


Ser Lys Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val 
865                 870                 875                 880 


Val Glu Lys Met Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu 
                885                 890                 895     


Ile Ser Glu Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Glu Arg 
            900                 905                 910         


Gly Gly Leu Asn Glu Leu Asp Lys Val Gly Phe Ile Lys Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Phe Leu Asp Ala 
    930                 935                 940                 


Arg Phe Asn Lys Glu Val Thr Glu Lys Asp Lys Lys Asn Arg Asn Val 
945                 950                 955                 960 


Lys Ile Ile Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu 
                965                 970                 975     


Phe Gly Leu Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Leu  Ala Lys Ala Ile Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly Asp Tyr  Gln Lys Tyr 
    1010                 1015                 1020             


Asp Leu  Gln Arg Tyr Ile Ser  Lys Ser Arg Glu Pro  Lys Glu Val 
    1025                 1030                 1035             


Glu Lys  Ala Thr Gln Lys Tyr  Phe Phe Tyr Ser Asn  Leu Leu Asn 
    1040                 1045                 1050             


Phe Phe  Lys Glu Glu Val His  Tyr Ala Asp Gly Thr  Ile Val Lys 
    1055                 1060                 1065             


Arg Glu  Asn Ile Glu Tyr Ser  Lys Asp Thr Gly Glu  Ile Ala Trp 
    1070                 1075                 1080             


Asn Lys  Glu Lys Asp Phe Ala  Thr Val Lys Lys Val  Leu Ser Leu 
    1085                 1090                 1095             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1100                 1105                 1110             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1115                 1120                 1125             


Ile Pro  Arg Lys Thr Lys Glu  Ile Leu Trp Asp Thr  Thr Lys Tyr 
    1130                 1135                 1140             


Gly Gly  Phe Asp Ser Pro Val  Ile Ala Tyr Ser Ile  Leu Leu Ile 
    1145                 1150                 1155             


Ala Asp  Ile Glu Lys Gly Lys  Ala Lys Lys Leu Lys  Thr Val Lys 
    1160                 1165                 1170             


Thr Leu  Val Gly Ile Thr Ile  Met Glu Lys Ala Thr  Phe Glu Lys 
    1175                 1180                 1185             


Asn Pro  Ile Thr Phe Leu Glu  Asn Lys Gly Tyr His  Asn Val Arg 
    1190                 1195                 1200             


Lys Glu  Asn Ile Leu Cys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1205                 1210                 1215             


Glu Ser  Gly Arg Arg Arg Met  Leu Ala Ser Ala Lys  Glu Leu Gln 
    1220                 1225                 1230             


Lys Gly  Asn Glu Ile Val Leu  Pro Val Tyr Leu Thr  Thr Leu Leu 
    1235                 1240                 1245             


Tyr His  Ser Lys Asn Val His  Lys Leu Asp Glu Pro  Glu His Leu 
    1250                 1255                 1260             


Glu Tyr  Ile Gln Lys His Arg  Tyr Glu Phe Lys Asp  Leu Leu Asn 
    1265                 1270                 1275             


Leu Val  Ser Glu Phe Ser Gln  Lys Tyr Val Leu Ala  Asp Ala Asn 
    1280                 1285                 1290             


Leu Glu  Lys Ile Lys Asn Leu  Tyr Ala Asp Asn Glu  Gln Ala Asp 
    1295                 1300                 1305             


Ile Glu  Ile Leu Ala Asn Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1310                 1315                 1320             


Ala Leu  Gly Ala Pro Ala Ala  Phe Lys Phe Leu Gly  Lys Asp Val 
    1325                 1330                 1335             


Asp Arg  Lys Arg Tyr Thr Thr  Val Ser Glu Ile Leu  Asn Ala Thr 
    1340                 1345                 1350             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1355                 1360                 1365             


Leu Ser  Lys Leu Gly Glu Asp  
    1370                 1375 


<210>  587
<211>  1396
<212>  PRT
<213>  Streptococcus anginosus SK52 = DSM 20563

<400>  587

Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asn Arg Asp Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Glu Thr Ala Glu Gly Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Met Gln Val Asp Glu Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Glu Glu Asp Lys Gln 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Gly Thr Leu Lys Glu Glu Lys Glu Tyr 
        115                 120                 125             


His Lys Lys Phe Lys Thr Ile Tyr His Leu Arg Glu Glu Leu Ala Asn 
    130                 135                 140                 


Ser Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Tyr Glu Gly Asp Leu Lys Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Ala Leu Phe Lys Asp Phe Val Glu Glu Tyr 
            180                 185                 190         


Asp Lys Thr Ile Glu Glu Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Ser Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala His Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Ala Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Gly Leu Leu Gly Glu Val Gly Asp Glu Tyr Ala Asp 
        275                 280                 285             


Leu Phe Val Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Lys Glu His Lys Glu Glu Leu Ala Ala Phe Lys 
                325                 330                 335     


Arg Phe Ile Lys Glu Lys Leu Pro Lys Lys Tyr Glu Glu Ile Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Val Gly Ala Asp Lys Lys 
        355                 360                 365             


Leu Arg Lys Arg Ser Gly Lys Leu Ala Thr Glu Glu Glu Phe Tyr Lys 
    370                 375                 380                 


Tyr Val Lys Gly Ile Leu Asn Lys Val Glu Gly Ala Asp Tyr Phe Leu 
385                 390                 395                 400 


Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg Lys Gln Arg Thr Phe Asp 
                405                 410                 415     


Asn Gly Ser Ile Pro His Gln Ile His Leu Gln Glu Met His Ala Ile 
            420                 425                 430         


Leu Arg Arg Gln Gly Glu His Tyr Pro Phe Leu Lys Glu Asn Gln Asp 
        435                 440                 445             


Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro 
    450                 455                 460                 


Leu Ala Arg Lys Gly Ser Arg Phe Ala Trp Ala Glu Tyr Lys Ala Asp 
465                 470                 475                 480 


Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp Ile Leu Asp Lys Glu Lys 
                485                 490                 495     


Ser Ala Glu Lys Phe Ile Thr Arg Met Thr Leu Asn Asp Leu Tyr Leu 
            500                 505                 510         


Pro Glu Glu Lys Val Leu Pro Lys His Ser Pro Leu Tyr Glu Thr Phe 
        515                 520                 525             


Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Asn Glu Gln Gly 
    530                 535                 540                 


Glu Ala Lys Phe Phe Asp Thr Asn Met Lys Gln Glu Ile Phe Asp His 
545                 550                 555                 560 


Val Phe Lys Glu Asn Arg Lys Val Thr Lys Asp Lys Leu Leu Asn Tyr 
                565                 570                 575     


Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile Val Asn Leu Thr Gly Leu 
            580                 585                 590         


Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
        595                 600                 605             


Leu Arg Lys Ile Leu Asp Lys Ser Phe Leu Asp Asp Lys Val Asn Glu 
    610                 615                 620                 


Lys Ile Ile Glu Asp Ile Ile Gln Thr Leu Thr Leu Phe Glu Asp Arg 
625                 630                 635                 640 


Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr Ser Asp Ile Phe Thr Thr 
                645                 650                 655     


Gln Gln Leu Lys Glu Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg 
            660                 665                 670         


Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg Asn Lys Glu Asn Lys Lys 
        675                 680                 685             


Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Tyr Ala Asn Arg Asn Phe 
    690                 695                 700                 


Met Gln Leu Ile Asn Asp Asp Ala Leu Ser Phe Lys Glu Glu Ile Ala 
705                 710                 715                 720 


Arg Ala Gln Ile Ile Gly Asp Val Asp Asp Ile Ala Asn Val Val His 
                725                 730                 735     


Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Val 
            740                 745                 750         


Lys Ile Val Asp Glu Leu Val Lys Val Met Gly His Asn Pro Thr Asn 
        755                 760                 765             


Ile Ile Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Asp Lys Gly Arg 
    770                 775                 780                 


Arg Asn Ser Gln Gln Arg Leu Lys Leu Leu Gln Asp Ser Leu Lys Asn 
785                 790                 795                 800 


Leu Asp Asn Pro Val Asn Ile Lys Asn Val Glu Asn Gln Gln Leu Gln 
                805                 810                 815     


Asn Asp Arg Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met Tyr 
            820                 825                 830         


Thr Gly Glu Thr Leu Asp Ile Asn Asn Leu Ser Gln Tyr Asp Ile Asp 
        835                 840                 845             


His Ile Ile Pro Gln Ala Phe Ile Lys Asp Asn Ser Leu Asp Asn Arg 
    850                 855                 860                 


Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asp Val Pro 
865                 870                 875                 880 


Ser Ile Glu Val Val His Glu Met Lys Ser Phe Trp Ser Lys Leu Leu 
                885                 890                 895     


Ser Val Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala 
            900                 905                 910         


Glu Arg Gly Gly Leu Thr Glu Asn Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Val Leu 
    930                 935                 940                 


Asp Ala Arg Phe Asn Ala Lys His Asp Glu Asn Lys Lys Val Ile Arg 
945                 950                 955                 960 


Asp Val Lys Ile Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe Arg 
                965                 970                 975     


Lys Asp Phe Lys Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His 
            980                 985                 990         


Ala His Asp Ala Tyr Leu Asn Ala  Val Ile Gly Thr Ala  Leu Leu Lys 
        995                 1000                 1005             


Lys Tyr  Pro Lys Leu Ala Ser  Glu Phe Val Tyr Gly  Glu Phe Lys 
    1010                 1015                 1020             


Lys Tyr  Asp Val Arg Lys Phe  Ile Ala Lys Ser Asp  Lys Glu Ile 
    1025                 1030                 1035             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Leu Met Asn 
    1040                 1045                 1050             


Phe Phe  Lys Lys Glu Val Lys  Phe Ala Asp Gly Thr  Val Val Glu 
    1055                 1060                 1065             


Arg Pro  Asp Ile Glu Thr Ser  Glu Asp Gly Glu Ile  Ala Trp Asn 
    1070                 1075                 1080             


Lys Gln  Thr Asp Phe Lys Ile  Val Arg Lys Val Leu  Ser Tyr Pro 
    1085                 1090                 1095             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  His Gly Leu 
    1100                 1105                 1110             


Asp Arg  Gly Lys Pro Arg Gly  Leu Phe Asn Ala Asn  Pro Ser Pro 
    1115                 1120                 1125             


Lys Pro  Lys Pro Asp Ser Ser  Glu Asn Leu Val Gly  Ile Lys Arg 
    1130                 1135                 1140             


Asn Leu  Asp Pro Lys Lys Tyr  Gly Gly Tyr Ala Gly  Ile Ser Asn 
    1145                 1150                 1155             


Ser Tyr  Ala Val Leu Val Lys  Ala Ile Ile Glu Lys  Gly Val Lys 
    1160                 1165                 1170             


Lys Lys  Glu Thr Met Val Leu  Glu Phe Gln Gly Ile  Ser Ile Leu 
    1175                 1180                 1185             


Asp Arg  Ile Thr Phe Glu Lys  Asp Lys Arg Ala Phe  Leu Leu Gly 
    1190                 1195                 1200             


Lys Gly  Tyr Lys Asp Ile Lys  Lys Ile Ile Glu Leu  Pro Lys Tyr 
    1205                 1210                 1215             


Ser Leu  Phe Glu Leu Lys Asp  Gly Ser Arg Arg Met  Leu Ala Ser 
    1220                 1225                 1230             


Ile Leu  Ser Thr Asn Asn Lys  Arg Gly Glu Ile His  Lys Gly Asn 
    1235                 1240                 1245             


Glu Leu  Phe Val Pro Gln Lys  Phe Thr Thr Leu Leu  Tyr His Ala 
    1250                 1255                 1260             


Lys Arg  Ile Asn Asn Pro Ile  Asn Lys Asp His Ile  Glu Tyr Val 
    1265                 1270                 1275             


Lys Lys  His Arg Asp Asp Phe  Lys Glu Leu Leu Asn  Tyr Val Leu 
    1280                 1285                 1290             


Glu Phe  Asn Glu Lys Tyr Val  Gly Ala Thr Lys Asn  Gly Glu Arg 
    1295                 1300                 1305             


Leu Lys  Glu Ala Val Ala Asp  Phe Asp Ser Lys Ser  Asn Glu Glu 
    1310                 1315                 1320             


Ile Cys  Thr Ser Phe Leu Gly  Ala Val Asn Ser Lys  Asn Ala Gly 
    1325                 1330                 1335             


Leu Phe  Glu Leu Thr Ser Leu  Gly Ser Ala Ser Asp  Phe Glu Phe 
    1340                 1345                 1350             


Leu Gly  Val Lys Ile Pro Arg  Tyr Arg Asp Tyr Thr  Pro Ser Ser 
    1355                 1360                 1365             


Leu Leu  Lys Asp Ser Ile Leu  Ile His Gln Ser Ile  Thr Gly Leu 
    1370                 1375                 1380             


Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu Gly Glu  Asp 
    1385                 1390                 1395     


<210>  588
<211>  1367
<212>  PRT
<213>  Streptococcus pyogenes MGAS1882

<400>  588

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Gly Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Ile Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Ala Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Gly Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  589
<211>  1345
<212>  PRT
<213>  Streptococcus mutans 8ID3

<400>  589

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Ile Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Asn  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  590
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae COH1

<400>  590

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Tyr Ser Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ser Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Asp Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asn Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Arg Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gln Asn Ile Asp 
        195                 200                 205             


Val Glu Gly Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Val Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Thr Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Gly Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Leu Val Asp Lys Glu Ala Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Ser Asp 
        675                 680                 685             


Gly Arg Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Pro Ile Ile Asp Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Val Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Thr Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Glu Glu Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Asp Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Ala Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Phe 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Asp Asp Lys  Leu Met Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Tyr 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Leu Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Gln  Lys Gln Glu Phe Val  Val Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  591
<211>  1385
<212>  PRT
<213>  Streptococcus salivarius K12

<400>  591

Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Ser Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Ile Thr Ala Glu Gly Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Thr Glu Met Ala Thr Leu Asp Asp Ala 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Pro Asp Asp Lys Arg 
            100                 105                 110         


Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val Glu Glu Lys Val Tyr 
        115                 120                 125             


His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Ser Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Asp Phe Asn Ser 
                165                 170                 175     


Lys Asn Asn Asp Leu Gln Lys Asn Phe Gln Asp Phe Leu Asp Thr Tyr 
            180                 185                 190         


Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu Asn Ser Lys Gln Leu 
        195                 200                 205             


Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser Gly Ile Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Arg Lys Tyr Phe 
                245                 250                 255     


Asn Leu Asp Glu Lys Thr Ser Leu Gln Phe Ser Lys Glu Ser Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Thr Leu Leu Gly His Ile Gly Asp Asp Tyr Ser Asp 
        275                 280                 285             


Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Asn Gly Thr Glu Ala Pro Leu Ser Ser Ala 
305                 310                 315                 320 


Met Ile Met Arg Tyr Lys Glu His Glu Glu Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Ala Tyr Ile Arg Asn Ile Ser Leu Glu Thr Tyr Asn Glu Val Phe Lys 
            340                 345                 350         


Asp Asn Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Ser 
        355                 360                 365             


Gln Glu Asp Phe Tyr Val Tyr Leu Lys Arg Leu Leu Ala Gly Leu Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile Tyr Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Leu Asp Lys Gln Ala Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala Trp 
    450                 455                 460                 


Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro Trp Asn Phe Glu Asp 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Asn Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Arg 
        515                 520                 525             


Phe Ile Ala Glu Gly Met Arg Asp Tyr Gln Phe Leu Asp Ser Lys Gln 
    530                 535                 540                 


Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Gly Lys Arg Lys Val Thr 
545                 550                 555                 560 


Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile Asp Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ser Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys Glu Phe Leu Asp Asp 
        595                 600                 605             


Ser Ser Asn Glu Thr Ile Ile Glu Glu Ile Ile His Thr Leu Thr Met 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ser Lys Phe Asp Asn 
625                 630                 635                 640 


Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Glu 
            660                 665                 670         


Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Val Ser 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ala Leu Ser Phe Lys 
    690                 695                 700                 


Lys Lys Ile Lys Lys Ala Gln Ile Ile Gly Asp Lys Asp Asn Ile Lys 
705                 710                 715                 720 


Gln Val Val Lys Ser Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


Glu Pro Glu Ser Ile Val Val Glu Met Ala Arg Glu Asn Gln Tyr Thr 
        755                 760                 765             


Asn Gln Gly Lys Ser Asn Ser Gln Gln Arg Leu Lys Arg Leu Glu Glu 
    770                 775                 780                 


Ser Leu Lys Gly Leu Gly Ser Lys Ile Leu Lys Glu Asn Val Pro Thr 
785                 790                 795                 800 


Arg Leu Ser Lys Ile Asp Asn Asn Ala Leu Gln Asn Asp Arg Leu Tyr 
                805                 810                 815     


Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Glu Glu Leu 
            820                 825                 830         


Asp Ile Asp Arg Leu Ser Asn Tyr Asp Ile Asp His Ile Ile Pro Gln 
        835                 840                 845             


Ala Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Val Ser Ser 
    850                 855                 860                 


Ala Ser Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Val Val 
865                 870                 875                 880 


Lys Lys Arg Lys Thr Leu Trp Tyr Gln Leu Leu Lys Ser Lys Leu Ile 
                885                 890                 895     


Ser Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu 
            900                 905                 910         


Ser Gln Glu Glu Lys Ala Gly Phe Ile Gln Arg Gln Leu Val Glu Thr 
        915                 920                 925             


Arg Gln Ile Thr Lys His Val Ala Arg Leu Leu Asp Glu Arg Phe Asn 
    930                 935                 940                 


Asn Lys Lys Asp Glu Asn Asn Arg Thr Leu Arg Thr Val Lys Ile Ile 
945                 950                 955                 960 


Thr Leu Lys Ser Ser Leu Val Ser Gln Phe Arg Lys Asp Phe Glu Leu 
                965                 970                 975     


Tyr Lys Val Arg Glu Ile Asn Asp Phe His His Ala His Asp Ala Tyr 
            980                 985                 990         


Leu Asn Ala Val Val Ala Ser Ala  Leu Leu Lys Lys Tyr  Pro Lys Leu 
        995                 1000                 1005             


Glu Pro  Glu Phe Val Tyr Gly  Asp Tyr Pro Lys Tyr  Asn Ser Phe 
    1010                 1015                 1020             


Arg Glu  Arg Lys Ser Ala Thr  Glu Lys Val Tyr Phe  Tyr Ser Asn 
    1025                 1030                 1035             


Ile Met  Asn Ile Phe Lys Lys  Ser Ile Pro Leu Ala  Asp Gly Thr 
    1040                 1045                 1050             


Val Ile  Asp Arg Pro Leu Ile  Glu Val Asn Glu Glu  Thr Gly Glu 
    1055                 1060                 1065             


Ser Val  Trp Asn Lys Val Ala  Asp Leu Asn Thr Val  Arg Lys Val 
    1070                 1075                 1080             


Leu Ser  Tyr Ser Gln Val Asn  Ile Val Lys Lys Val  Glu Glu Gln 
    1085                 1090                 1095             


Asn His  Gly Leu Asp Arg Gly  Lys Pro Lys Gly Leu  Phe Asn Ala 
    1100                 1105                 1110             


Asn Leu  Ser Ser Lys Pro Lys  Pro Asn Ser Lys Glu  Asn Leu Val 
    1115                 1120                 1125             


Gly Ala  Lys Glu Tyr Leu Asp  Pro Lys Lys Tyr Gly  Gly Tyr Ala 
    1130                 1135                 1140             


Gly Ile  Ser Asn Ser Phe Ala  Ile Leu Val Lys Gly  Thr Ile Glu 
    1145                 1150                 1155             


Lys Gly  Ala Lys Lys Lys Ile  Thr Asn Val Leu Glu  Phe Gln Gly 
    1160                 1165                 1170             


Ile Ser  Ile Leu Asp Arg Ile  Tyr Tyr Arg Lys Asp  Lys Leu Asn 
    1175                 1180                 1185             


Phe Leu  Leu Glu Lys Gly Tyr  Lys Asp Ile Glu Leu  Ile Ile Glu 
    1190                 1195                 1200             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Ser Asp Gly  Ser Arg Arg 
    1205                 1210                 1215             


Met Leu  Ala Ser Ile Leu Ser  Thr Asn Asn Lys Arg  Gly Glu Ile 
    1220                 1225                 1230             


His Lys  Gly Asn Gln Ile Phe  Ile Ser Gln Lys Phe  Val Lys Leu 
    1235                 1240                 1245             


Leu Tyr  His Ala Lys Arg Ile  Ser Ser Thr Phe Asn  Glu Asn His 
    1250                 1255                 1260             


Arg Lys  Tyr Val Glu Asn His  Lys Lys Glu Phe Glu  Glu Leu Phe 
    1265                 1270                 1275             


Tyr Tyr  Ile Leu Glu Phe Asn  Glu Asn Tyr Val Gly  Ala Lys Lys 
    1280                 1285                 1290             


Asn Gly  Glu Leu Leu Lys Ser  Ala Phe Gln Ser Trp  Gln Asn His 
    1295                 1300                 1305             


Ser Ile  Asp Glu Leu Cys Ser  Ser Phe Ile Gly Pro  Thr Gly Ser 
    1310                 1315                 1320             


Glu Arg  Lys Gly Leu Phe Glu  Leu Thr Ser Arg Gly  Gly Ala Ala 
    1325                 1330                 1335             


Asp Phe  Glu Phe Leu Gly Val  Lys Ile Pro Arg Tyr  Arg Asp Tyr 
    1340                 1345                 1350             


Thr Pro  Ser Ser Leu Leu Lys  Asp Ala Thr Leu Ile  His Gln Ser 
    1355                 1360                 1365             


Val Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1370                 1375                 1380             


Glu Asp  
    1385 


<210>  592
<211>  1392
<212>  PRT
<213>  Streptococcus sanguinis SK330

<400>  592

Met Glu Asn Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Phe Gly Asn Thr Asp Lys His Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Ala Thr Ala Glu Asp Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ser Glu Glu Ile Ser Lys Leu Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Val Pro Lys Asp Lys 
            100                 105                 110         


Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Glu Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ser Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 
    210                 215                 220                 


Arg Val Leu Lys Leu Phe Ser Asp Glu Lys Ser Thr Ser Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Gly Phe Thr 
        275                 280                 285             


Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Ser His Gln Lys Asp Leu Ala Ala Leu 
                325                 330                 335     


Lys Gln Phe Ile Lys Asn Asn Leu Pro Lys Arg Tyr Asn Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Glu Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Glu Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly 
    530                 535                 540                 


Gln Lys Lys Gln Ile Val Asn Gln Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile His Tyr Leu His Asn Val Asp Gly Tyr Asp 
                565                 570                 575     


Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Met Asp 
        595                 600                 605             


Asp Pro Lys Asn Glu Glu Ile Leu Glu Asn Ile Val His Thr Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asp 
625                 630                 635                 640 


Ser Ile Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Cys Asp 
            660                 665                 670         


Lys Gln Thr Gly Asp Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Lys 
        675                 680                 685             


Ile Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe 
    690                 695                 700                 


Lys Glu Ile Ile Gln Lys Ala Gln Val Val Gly Lys Thr Asp Asp Val 
705                 710                 715                 720 


Lys Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Tyr Ala Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu 
    770                 775                 780                 


Asp Ser Leu Lys Asn Leu Ala Pro Gly Leu Asp Ser Asn Ile Leu Lys 
785                 790                 795                 800 


Glu Asn Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Lys Pro Leu Asp 
            820                 825                 830         


Ile Asp Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Ile Pro Gln Ala 
        835                 840                 845             


Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys 
    850                 855                 860                 


Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val Val Gln 
865                 870                 875                 880 


Lys Arg Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser 
                885                 890                 895     


Glu Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asp 
            900                 905                 910         


Glu Arg Asp Lys Val Gly Phe Ile Arg Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala Ser Phe Asn Thr 
    930                 935                 940                 


Glu Val Asn Glu Lys Asn Gln Lys Ile Arg Thr Val Lys Ile Ile Thr 
945                 950                 955                 960 


Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Ala Val Val Ala Lys Ala Ile  Leu Lys Lys Tyr Pro  Lys Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Asp  Tyr Gln Lys Tyr Asp  Leu Lys Arg 
    1010                 1015                 1020             


Tyr Ile  Ser Arg Phe Lys Pro  Ser Lys Glu Ile Glu  Lys Ala Thr 
    1025                 1030                 1035             


Glu Lys  Tyr Phe Phe Tyr Ser  Asn Leu Leu Asn Phe  Phe Lys Glu 
    1040                 1045                 1050             


Glu Val  His Tyr Ala Asp Gly  Ile Ile Val Lys Arg  Glu Asn Ile 
    1055                 1060                 1065             


Glu Tyr  Ser Lys Asp Thr Gly  Glu Ile Ala Trp Asn  Lys Glu Lys 
    1070                 1075                 1080             


Asp Phe  Ala Thr Ile Lys Lys  Val Leu Ser Tyr Pro  Gln Val Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Thr Glu Ile  Gln Thr His Gly Leu  Asp Arg Gly 
    1100                 1105                 1110             


Lys Pro  Lys Gly Leu Phe Asn  Ser Asn Pro Ser Pro  Lys Pro Ser 
    1115                 1120                 1125             


Glu Asp  Ser Lys Glu Asn Leu  Val Pro Ile Lys Gln  Gly Leu Asp 
    1130                 1135                 1140             


Pro Arg  Lys Tyr Gly Gly Tyr  Ala Gly Ile Ser Asn  Ser Tyr Ala 
    1145                 1150                 1155             


Val Leu  Val Lys Ala Ile Val  Glu Lys Gly Ala Lys  Lys Gln Gln 
    1160                 1165                 1170             


Lys Thr  Ile Leu Glu Phe Gln  Gly Ile Ser Ile Leu  Asp Lys Ile 
    1175                 1180                 1185             


Asn Phe  Glu Asn Asn Lys Glu  Asn Tyr Leu Leu Lys  Lys Arg Tyr 
    1190                 1195                 1200             


Ile Glu  Ile Leu Ser Thr Ile  Thr Leu Pro Lys Tyr  Ser Leu Phe 
    1205                 1210                 1215             


Glu Phe  Pro Asp Gly Thr Arg  Arg Arg Leu Ala Ser  Ile Leu Ser 
    1220                 1225                 1230             


Thr Asn  Asn Lys Arg Gly Glu  Ile His Lys Gly Asn  Glu Leu Val 
    1235                 1240                 1245             


Leu Pro  Gly Lys Tyr Thr Thr  Leu Leu Tyr His Ala  Lys Asn Ile 
    1250                 1255                 1260             


Asn Lys  Lys Leu Glu Pro Glu  His Leu Glu Tyr Val  Glu Lys His 
    1265                 1270                 1275             


Arg Asn  Asp Phe Ala Lys Leu  Leu Glu Cys Val Leu  Asn Phe Asn 
    1280                 1285                 1290             


Asp Lys  Tyr Val Gly Ala Leu  Lys Asn Gly Glu Arg  Ile Arg Gln 
    1295                 1300                 1305             


Ala Phe  Thr Asp Trp Glu Thr  Val Asp Ile Glu Lys  Leu Cys Phe 
    1310                 1315                 1320             


Ser Phe  Ile Gly Pro Glu Asn  Ser Lys Asn Ala Gly  Leu Phe Glu 
    1325                 1330                 1335             


Leu Thr  Ser Gln Gly Ser Ala  Ser Asp Phe Glu Phe  Leu Gly Val 
    1340                 1345                 1350             


Lys Ile  Pro Arg Tyr Arg Asp  Tyr Ala Pro Ser Ser  Leu Leu Lys 
    1355                 1360                 1365             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1370                 1375                 1380             


Ile Asp  Leu Ser Lys Leu Gly  Glu Asp 
    1385                 1390         


<210>  593
<211>  1371
<212>  PRT
<213>  Streptococcus sp. oral taxon 056 str. F0418

<400>  593

Met Asn Asn Asn Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Arg Val Leu Gly Asn Thr Asp Lys Arg Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Asp Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Val Pro Glu Asp Lys 
            100                 105                 110         


Ser Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Ala Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Ile Thr Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ala Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Asn Ile 
            180                 185                 190         


Tyr Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Gly Lys Ile Ser Lys Ser Val Lys Arg Glu 
    210                 215                 220                 


His Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Ser Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Asn His Gln Glu Asp Leu Ala Ala Leu 
                325                 330                 335     


Lys Gln Phe Ile Lys Asn Asn Leu Pro Glu Lys Tyr Ala Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Glu Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Leu Leu Lys Glu Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Ser Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Phe Asp Ser Gly 
    530                 535                 540                 


Gln Lys Lys Gln Ile Val Asn Gln Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile His Tyr Leu His Asn Val Asp Gly Tyr Asp 
                565                 570                 575     


Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Met Asp 
        595                 600                 605             


Asn His Lys Asn Gln Glu Ile Leu Glu Asn Ile Val His Thr Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asp 
625                 630                 635                 640 


Ser Ile Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Cys Asp 
            660                 665                 670         


Lys Lys Thr Gly Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Tyr 
        675                 680                 685             


Asn Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe 
    690                 695                 700                 


Lys Glu Ile Ile Gln Lys Ala Gln Val Val Gly Lys Thr Asp Asp Leu 
705                 710                 715                 720 


Thr Gln Val Val Arg Glu Leu Ser Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Ile Met Gly 
            740                 745                 750         


Tyr Ala Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Lys Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu 
    770                 775                 780                 


Asp Ala Leu Lys Asn Leu Ala Pro Gly Leu Asp Ser Thr Ile Ser Lys 
785                 790                 795                 800 


Glu Asn Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Glu Ala Leu Asp 
            820                 825                 830         


Ile Asn Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Ile Pro Gln Ala 
        835                 840                 845             


Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys 
    850                 855                 860                 


Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val Val Lys 
865                 870                 875                 880 


Lys Arg Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser 
                885                 890                 895     


Glu Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asp 
            900                 905                 910         


Glu Arg Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Ala Arg Phe Asn Thr 
    930                 935                 940                 


Glu Val Ser Glu Lys Asn Gln Lys Ile Arg Ser Val Lys Ile Ile Thr 
945                 950                 955                 960 


Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Lys Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Ala Val Val Ala Lys Ala Ile  Leu Lys Lys Tyr Pro  Lys Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Asp  Tyr Gln Lys Tyr Asp  Leu Lys Arg 
    1010                 1015                 1020             


Tyr Ile  Ser Lys Ser Lys Asp  Pro Lys Glu Val Glu  Lys Ala Thr 
    1025                 1030                 1035             


Glu Lys  Tyr Phe Phe Tyr Ser  Asn Leu Leu Asn Phe  Phe Lys Glu 
    1040                 1045                 1050             


Glu Val  His Tyr Ala Asp Gly  Thr Ile Val Lys Arg  Glu Asn Ile 
    1055                 1060                 1065             


Glu Tyr  Ser Lys Asp Thr Gly  Glu Ile Ala Trp Asn  Lys Glu Lys 
    1070                 1075                 1080             


Asp Phe  Val Thr Ile Lys Lys  Val Leu Ser Tyr Pro  Gln Val Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Arg Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1100                 1105                 1110             


Ser Ile  Leu Pro Lys Gly Asn  Ser Asp Lys Leu Ile  Pro Arg Lys 
    1115                 1120                 1125             


Thr Lys  Asp Ile Leu Trp Asp  Thr Thr Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Val Ile Ala Tyr Ser  Ile Leu Leu Ile Ala  Asp Ile Glu 
    1145                 1150                 1155             


Lys Gly  Lys Ala Lys Lys Leu  Lys Thr Val Lys Thr  Leu Val Gly 
    1160                 1165                 1170             


Ile Thr  Ile Met Glu Lys Ala  Ala Phe Glu Lys Asn  Pro Ile Thr 
    1175                 1180                 1185             


Phe Leu  Glu Asn Lys Gly Tyr  His Asn Val Arg Lys  Glu Asn Ile 
    1190                 1195                 1200             


Leu Cys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1205                 1210                 1215             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Leu Gln Lys  Gly Asn Glu 
    1220                 1225                 1230             


Ile Val  Leu Pro Val Tyr Leu  Thr Thr Leu Leu Tyr  His Ser Lys 
    1235                 1240                 1245             


Asn Val  His Lys Leu Asp Glu  Pro Glu His Leu Glu  Tyr Ile Gln 
    1250                 1255                 1260             


Lys His  Arg Tyr Glu Phe Lys  Asp Leu Leu Asn Leu  Val Ser Glu 
    1265                 1270                 1275             


Phe Ser  Gln Lys Tyr Val Leu  Ala Glu Ala Asn Leu  Glu Lys Ile 
    1280                 1285                 1290             


Lys Ser  Leu Tyr Val Asp Asn  Glu Gln Ala Asp Ile  Glu Ile Leu 
    1295                 1300                 1305             


Ala Asn  Ser Phe Ile Asn Leu  Leu Thr Phe Thr Ala  Leu Gly Ala 
    1310                 1315                 1320             


Pro Ala  Ala Phe Lys Phe Phe  Gly Lys Asp Val Asp  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Thr  Thr Val Ser Glu Ile  Leu Asn Ala Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu 
    1355                 1360                 1365             


Gly Glu  Asp 
    1370     


<210>  594
<211>  1370
<212>  PRT
<213>  Streptococcus gallolyticus subsp. gallolyticus TX20005

<400>  594

Met Thr Lys Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Lys Tyr Ile Lys Lys Asn Leu 
        35                  40                  45              


Leu Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Thr Lys Val Asp Glu 
                85                  90                  95      


Ser Phe Phe Tyr Arg Leu Asp Glu Ser Phe Leu Thr Thr Asp Glu Lys 
            100                 105                 110         


Asp Phe Glu Arg His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala 
        115                 120                 125             


Tyr His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Asn Tyr Leu Ala 
    130                 135                 140                 


Asp Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Asn 
                165                 170                 175     


Ala Glu Asn Thr Asp Val Gln Lys Leu Phe Thr Asp Phe Val Gly Val 
            180                 185                 190         


Tyr Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp 
        195                 200                 205             


Val Ala Ser Thr Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu 
    210                 215                 220                 


Asn Leu Ile Lys Tyr Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Met Asn 
                245                 250                 255     


Phe Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Glu Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala 
        275                 280                 285             


Asp Leu Phe Thr Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Lys Arg Tyr Val Glu His His Glu Asp Leu Glu Lys Leu 
                325                 330                 335     


Lys Glu Phe Ile Lys Ala Asn Lys Ser Glu Leu Tyr His Asp Ile Phe 
            340                 345                 350         


Lys Asp Lys Asn Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val 
        355                 360                 365             


Lys Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile 
    370                 375                 380                 


Asp Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Lys Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Val Arg Lys Asp Ser Arg Phe Ala 
    450                 455                 460                 


Trp Ala Glu Tyr Arg Ser Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp 
465                 470                 475                 480 


Lys Val Ile Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met 
                485                 490                 495     


Thr Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser His Val Tyr Glu Thr Tyr Ala Val Tyr Asn Glu Leu Thr Lys Ile 
        515                 520                 525             


Lys Tyr Val Asn Glu Gln Gly Lys Glu Ser Phe Phe Asp Ser Asn Met 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr 
545                 550                 555                 560 


Lys Glu Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Pro Glu Tyr Arg 
                565                 570                 575     


Ile Lys Asp Leu Ile Gly Leu Asp Lys Glu Asn Lys Ser Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Ala Phe 
        595                 600                 605             


Leu Asp Asp Lys Val Asn Glu Glu Val Ile Glu Asp Ile Ile Lys Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Lys Asp Met Ile His Glu Arg Leu Gln Lys 
625                 630                 635                 640 


Tyr Ser Asp Ile Phe Thr Ala Asn Gln Leu Lys Lys Leu Glu Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asn Lys Glu Asn Asn Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Ser Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Thr Leu 
    690                 695                 700                 


Pro Phe Lys Gln Ile Ile Gln Lys Ser Gln Val Val Gly Asp Val Asp 
705                 710                 715                 720 


Asp Ile Glu Ala Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Asp Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Arg Gly Arg Ser Gln Ser Gln Gln Arg Leu Lys Lys 
    770                 775                 780                 


Leu Gln Ser Ser Leu Lys Glu Leu Gly Ser Asn Ile Leu Asn Glu Glu 
785                 790                 795                 800 


Lys Pro Ser Tyr Ile Glu Asp Lys Val Glu Asn Ser His Leu Gln Asn 
                805                 810                 815     


Asp Gln Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met Tyr Thr 
            820                 825                 830         


Gly Asp Glu Leu Asp Ile Asp His Leu Ser Asp Tyr Asp Ile Asp His 
        835                 840                 845             


Ile Ile Pro Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val 
    850                 855                 860                 


Leu Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser 
865                 870                 875                 880 


Leu Asp Ile Val Arg Ala Arg Lys Ala Glu Trp Val Arg Leu Tyr Lys 
                885                 890                 895     


Ser Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu 
            900                 905                 910         


Arg Gly Gly Leu Thr Glu Ala Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp 
    930                 935                 940                 


Ala Arg Phe Asn Thr Glu His Asp Glu Asn Asp Lys Val Ile Arg Asp 
945                 950                 955                 960 


Val Lys Val Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe Arg Lys 
                965                 970                 975     


Asp Phe Glu Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Lys Leu Ala Ser Glu  Phe Val Tyr Gly Glu  Tyr Lys Lys 
    1010                 1015                 1020             


Tyr Asp  Ile Arg Lys Phe Ile  Thr Asn Ser Ser Asp  Lys Ala Thr 
    1025                 1030                 1035             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Leu Met Asn Phe  Phe Lys Thr 
    1040                 1045                 1050             


Lys Val  Lys Tyr Ala Asp Gly  Thr Val Phe Glu Arg  Pro Ile Ile 
    1055                 1060                 1065             


Glu Thr  Asn Ala Asp Gly Glu  Ile Ala Trp Asn Lys  Gln Ile Asp 
    1070                 1075                 1080             


Phe Glu  Lys Val Arg Lys Val  Leu Ser Tyr Pro Gln  Val Asn Ile 
    1085                 1090                 1095             


Val Lys  Lys Val Glu Thr Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1100                 1105                 1110             


Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu Ile Pro  Arg Lys Thr 
    1115                 1120                 1125             


Lys Lys  Val Tyr Trp Asp Thr  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1130                 1135                 1140             


Pro Thr  Val Ala Tyr Ser Val  Phe Val Val Ala Asp  Val Glu Lys 
    1145                 1150                 1155             


Gly Lys  Ala Lys Lys Leu Lys  Thr Val Lys Glu Leu  Val Gly Ile 
    1160                 1165                 1170             


Ser Ile  Met Glu Arg Ser Phe  Phe Glu Glu Asn Pro  Val Glu Phe 
    1175                 1180                 1185             


Leu Glu  Asn Lys Gly Tyr His  Asn Ile Arg Glu Asp  Lys Leu Ile 
    1190                 1195                 1200             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Phe Glu Gly  Gly Arg Arg 
    1205                 1210                 1215             


Arg Leu  Leu Ala Ser Ala Ser  Glu Leu Gln Lys Gly  Asn Glu Met 
    1220                 1225                 1230             


Val Leu  Pro Gly Tyr Leu Val  Glu Leu Leu Tyr His  Ala His Arg 
    1235                 1240                 1245             


Ala Asp  Asn Phe Asn Ser Thr  Glu Tyr Leu Asn Tyr  Val Ser Glu 
    1250                 1255                 1260             


His Lys  Lys Glu Phe Glu Lys  Val Leu Ser Cys Val  Glu Asp Phe 
    1265                 1270                 1275             


Ala Asn  Leu Tyr Val Asp Val  Glu Lys Asn Leu Ser  Lys Ile Arg 
    1280                 1285                 1290             


Ala Val  Ala Asp Ser Met Asp  Asn Phe Ser Ile Glu  Glu Ile Ser 
    1295                 1300                 1305             


Asn Ser  Phe Ile Asn Leu Leu  Thr Leu Thr Ala Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Asp  Phe Asn Phe Leu Gly  Glu Lys Ile Pro Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Cys Leu  Thr Ala Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly 
    1355                 1360                 1365             


Glu Glu  
    1370 


<210>  595
<211>  1371
<212>  PRT
<213>  Streptococcus dysgalactiae subsp. equisimilis RE378

<400>  595

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Ser Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Met Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Glu Phe Leu Ser Gly Lys Gln 
    530                 535                 540                 


Lys Glu Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Ile Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Ala Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asp Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Glu Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asn Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Ala Leu Thr  Asn Glu Ser Ile Tyr  Ala Arg Gly 
    1100                 1105                 1110             


Ser Phe  Asp Lys Leu Ile Ser  Arg Lys His Arg Phe  Glu Ser Ser 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Gly Ser  Pro Thr Val Thr Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Ser Lys Val  Gln Asp Gly Lys Val  Lys Lys Ile 
    1145                 1150                 1155             


Lys Thr  Gly Lys Glu Leu Ile  Gly Ile Thr Leu Leu  Asp Lys Leu 
    1160                 1165                 1170             


Val Phe  Glu Lys Asn Pro Leu  Lys Phe Ile Glu Asp  Lys Gly Tyr 
    1175                 1180                 1185             


Gly Asn  Val Gln Ile Asp Lys  Cys Ile Lys Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Phe Glu Asn Gly  Thr Arg Arg Met Leu  Ala Ser Val 
    1205                 1210                 1215             


Met Ala  Asn Asn Asn Ser Arg  Gly Asp Leu Gln Lys  Ala Asn Glu 
    1220                 1225                 1230             


Met Phe  Leu Pro Ala Lys Leu  Val Thr Leu Leu Tyr  His Ala His 
    1235                 1240                 1245             


Lys Ile  Glu Ser Ser Lys Glu  Leu Glu His Glu Ala  Tyr Ile Leu 
    1250                 1255                 1260             


Asp His  Tyr Asn Asp Leu Tyr  Gln Leu Leu Ser Tyr  Ile Glu Arg 
    1265                 1270                 1275             


Phe Ala  Ser Leu Tyr Val Asp  Val Glu Lys Asn Ile  Ser Lys Val 
    1280                 1285                 1290             


Lys Glu  Leu Phe Ser Asn Ile  Glu Ser Tyr Ser Ile  Ser Glu Ile 
    1295                 1300                 1305             


Cys Ser  Ser Val Ile Asn Leu  Leu Thr Leu Thr Ala  Ser Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Lys Phe Leu  Gly Thr Thr Ile Pro  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Gly  Ser Pro Gln Ser Ile  Leu Ser Ser Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1355                 1360                 1365             


Gly Gly  Asp 
    1370     


<210>  596
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae SS1219

<400>  596

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Ser Phe Glu Asn Asn His Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Tyr Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Val 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Gln Leu Leu Asp Phe Leu Ala Lys Glu Phe Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Ile Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Arg Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Ser Asp 
        675                 680                 685             


Gly Arg Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ser Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Glu Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asp Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile Asp Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Ala Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Ile Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Pro Asp Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Lys Val Asp Asp Asn Asn Lys Pro Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Glu 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Glu Thr Gly 
    1055                 1060                 1065             


Glu Ile  Ala Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Ser Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Leu Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Lys Glu Leu Ile  Gly Ile Thr Ile Met  Glu Arg Glu 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Thr Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Tyr 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Ile Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Ser Asp Asn Lys Asp  Asn Thr Pro Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Lys Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ser Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asp Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  597
<211>  1345
<212>  PRT
<213>  Streptococcus mutans NCTC 11060

<400>  597

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Leu Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Gln Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asp His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  598
<211>  1345
<212>  PRT
<213>  Streptococcus mutans 4SM1

<400>  598

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Pro Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Glu  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  599
<211>  1377
<212>  PRT
<213>  Streptococcus sanguinis SK115

<400>  599

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys His Phe Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ser Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Ile Ser Lys Leu Asp Ser Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Asp Ser Phe Leu Val Pro Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Glu Glu Glu Lys Glu Tyr 
        115                 120                 125             


His Lys Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ser Phe Asp Ile 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Ser Ile Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln Val 
        195                 200                 205             


Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Thr Lys Arg Glu Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Ser Asp Glu Lys Ser Thr Gly Leu Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Gly Phe Ala Asp 
        275                 280                 285             


Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Glu Arg Tyr Glu Asn His Gln Glu Asp Leu Ala Ala Leu Lys 
                325                 330                 335     


Gln Phe Ile Lys Asn Asn Leu Ser Glu Lys Tyr Ala Glu Val Phe Ser 
            340                 345                 350         


Asp Gln Ser Lys Asp Gly Tyr Ala Gly Phe Ile Asp Gly Lys Thr Thr 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Leu Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Asn Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Leu Phe 
            420                 425                 430         


Leu Lys Glu Asn Arg Glu Lys Ile Glu Lys Ile Leu Ala Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala Trp 
    450                 455                 460                 


Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Ala Ser Ser Ala Glu Asp Phe Ile Asn Lys Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly Gln 
    530                 535                 540                 


Lys Lys Gln Ile Val Asn Gln Leu Phe Lys Asp Lys Arg Lys Val Thr 
545                 550                 555                 560 


Glu Lys Asp Ile Ile His Tyr Leu His Asn Val Asp Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Met Asp Asn 
        595                 600                 605             


Pro Lys Asn Gly Glu Ile Leu Glu Asn Ile Ile His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asp Thr 
625                 630                 635                 640 


Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Thr Gly Lys Thr Ile Leu Glu Tyr Leu Ile Asp Asp Gly Asp Cys 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe Lys 
    690                 695                 700                 


Glu Ile Ile Gln Lys Ala Gln Val Val Gly Lys Thr Asp Asp Val Lys 
705                 710                 715                 720 


Gln Val Val Gln Glu Ile Pro Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly His 
            740                 745                 750         


Asn Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu Asp 
    770                 775                 780                 


Ala Leu Lys Asn Leu Ala Pro Gly Leu Asp Ser Asn Ile Leu Lys Glu 
785                 790                 795                 800 


Asn Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr 
                805                 810                 815     


Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Lys Ala Ile Asp Ile 
            820                 825                 830         


Asn Gln Leu Ser Asn Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe 
        835                 840                 845             


Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys Asp 
    850                 855                 860                 


Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Glu Val Val Gln Lys 
865                 870                 875                 880 


Arg Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser Glu 
                885                 890                 895     


Arg Lys Phe Asn Asn Leu Thr Lys Ala Lys Arg Gly Gly Leu Asp Glu 
            900                 905                 910         


Arg Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
        915                 920                 925             


Ile Thr Lys His Val Ala Gln Leu Leu Asp Thr Arg Phe Asn Thr Glu 
    930                 935                 940                 


Val Asn Glu Glu Asn Gln Lys Ile Arg Thr Val Lys Ile Ile Thr Leu 
945                 950                 955                 960 


Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly Leu Tyr Lys 
                965                 970                 975     


Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn 
            980                 985                 990         


Ala Val Val Ala Lys Ala Ile Leu  Lys Lys Tyr Pro Lys  Leu Glu Pro 
        995                 1000                 1005             


Glu Phe  Val Tyr Gly Asp Tyr  Gln Lys Tyr Asp Leu  Lys Arg Tyr 
    1010                 1015                 1020             


Ile Leu  Lys Ser Lys Ala Ser  Asn Thr Ile Asp Lys  Ala Thr Glu 
    1025                 1030                 1035             


Lys Tyr  Phe Phe Tyr Ser Asn  Leu Leu Asn Phe Phe  Lys Glu Lys 
    1040                 1045                 1050             


Val Arg  Tyr Ala Asp Gly Thr  Ile Lys Lys Arg Glu  Asn Ile Glu 
    1055                 1060                 1065             


Tyr Ser  Asn Asp Thr Gly Glu  Ile Ala Trp Asn Lys  Glu Lys Asp 
    1070                 1075                 1080             


Phe Ala  Thr Ile Lys Lys Val  Leu Ser Leu Pro Gln  Val Asn Ile 
    1085                 1090                 1095             


Val Lys  Lys Thr Glu Glu Gln  Thr Val Gly Gln Asn  Gly Gly Leu 
    1100                 1105                 1110             


Phe Asp  Asn Asn Ile Val Ser  Lys Lys Lys Val Val  Asp Ala Ser 
    1115                 1120                 1125             


Lys Leu  Ile Pro Ile Lys Ser  Ser Leu Ser Pro Glu  Lys Tyr Gly 
    1130                 1135                 1140             


Gly Tyr  Ala Arg Pro Thr Ile  Ala Tyr Ser Val Leu  Val Ile Ala 
    1145                 1150                 1155             


Asp Ile  Glu Lys Gly Lys Gly  Lys Ala Lys Lys Leu  Lys Arg Ile 
    1160                 1165                 1170             


Lys Glu  Ile Val Gly Ile Thr  Ile Gln Asp Lys Lys  Lys Phe Glu 
    1175                 1180                 1185             


Ser Asn  Pro Val Thr Tyr Leu  Glu Glu Cys Gly Tyr  Lys Asn Ile 
    1190                 1195                 1200             


Asn Ser  Asn Leu Ile Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu 
    1205                 1210                 1215             


Phe Asn  Asp Gly Gln Arg Arg  Leu Leu Ala Ser Ser  Ile Glu Leu 
    1220                 1225                 1230             


Gln Lys  Gly Asn Glu Leu Ile  Leu Pro Tyr His Leu  Thr Ala Leu 
    1235                 1240                 1245             


Leu Tyr  His Ala Gln Arg Ile  Asn Lys Ile Ser Glu  Pro Ile His 
    1250                 1255                 1260             


Lys Gln  Tyr Val Glu Ala His  Gln Asn Glu Phe Lys  Glu Leu Leu 
    1265                 1270                 1275             


Thr Thr  Ile Ile Ser Leu Ser  Lys Lys Tyr Ile Gln  Lys Pro Asn 
    1280                 1285                 1290             


Val Glu  Leu Leu Leu Gln Gln  Ala Phe Asp Gln Ala  Asp Lys Asp 
    1295                 1300                 1305             


Ile Tyr  Gln Leu Ser Glu Ser  Phe Ile Ser Leu Leu  Lys Leu Thr 
    1310                 1315                 1320             


Ser Phe  Gly Ala Pro Gly Ala  Phe Lys Phe Leu Gly  Val Glu Ile 
    1325                 1330                 1335             


Ser Gln  Ser Ser Val Arg Tyr  Lys Pro Asn Ser Gln  Phe Leu Asp 
    1340                 1345                 1350             


Thr Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1355                 1360                 1365             


Ile Asp  Leu Ser Lys Leu Gly  Glu Asp 
    1370                 1375         


<210>  600
<211>  1345
<212>  PRT
<213>  Streptococcus mutans 2VS1

<400>  600

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  601
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes M1 476

<400>  601

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  602
<211>  1345
<212>  PRT
<213>  Streptococcus mutans U2B

<400>  602

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Asn  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  603
<211>  1345
<212>  PRT
<213>  Streptococcus mutans M2A

<400>  603

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Tyr Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Ala  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  604
<211>  1359
<212>  PRT
<213>  Streptococcus mutans 66-2A

<400>  604

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Met Gln Val Asp Glu Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Arg Tyr Pro Ile Phe Gly Thr Leu Lys Glu Glu Lys Lys Tyr 
        115                 120                 125             


His Lys Glu Phe Lys Thr Ile Tyr His Leu Arg Glu Lys Leu Ala Asn 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ser Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gln Leu Lys Ala 
                165                 170                 175     


Glu Asn Thr Asn Val Gln Ala Leu Phe Lys Asp Phe Val Glu Val Tyr 
            180                 185                 190         


Asp Lys Thr Val Glu Glu Ser His Leu Ser Glu Met Thr Val Asp Ala 
        195                 200                 205             


Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Val Glu Cys Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Gly Leu Leu Gly Glu Ile Gly Asp Glu Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Ala Val Asp Asp Asn Thr Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Lys Glu His Lys Glu Glu Leu Ala Ala Phe Lys 
                325                 330                 335     


Arg Phe Ile Lys Glu Lys Leu Pro Lys Lys Tyr Glu Glu Ile Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Val Gly Ala Asp Lys Lys 
        355                 360                 365             


Leu Arg Lys Arg Ser Gly Lys Leu Ala Thr Glu Glu Glu Phe Tyr Lys 
    370                 375                 380                 


Tyr Val Lys Gly Ile Leu Asn Lys Val Glu Gly Ala Asp Val Trp Leu 
385                 390                 395                 400 


Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg Lys Gln Arg Thr Phe Asp 
                405                 410                 415     


Asn Gly Ser Ile Pro His Gln Ile His Leu Gln Glu Met His Ala Ile 
            420                 425                 430         


Leu Arg Arg Gln Gly Glu His Tyr Pro Phe Leu Lys Glu Asn Gln Asp 
        435                 440                 445             


Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro 
    450                 455                 460                 


Leu Val Arg Lys Gly Ser Arg Phe Ala Trp Ala Glu Tyr Lys Ala Asp 
465                 470                 475                 480 


Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp Ile Leu Asp Lys Glu Lys 
                485                 490                 495     


Ser Ala Glu Lys Phe Ile Thr Arg Met Thr Leu Asn Asp Leu Tyr Leu 
            500                 505                 510         


Pro Glu Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Thr Phe 
        515                 520                 525             


Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Asn Glu Gln Gly 
    530                 535                 540                 


Glu Ala Lys Phe Phe Asp Ala Asn Met Lys Gln Glu Ile Phe Asp His 
545                 550                 555                 560 


Val Phe Lys Glu Asn Arg Lys Val Thr Lys Asp Lys Leu Leu Asn Tyr 
                565                 570                 575     


Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile Val Asn Leu Thr Gly Leu 
            580                 585                 590         


Asp Lys Glu Asn Lys Val Phe Asn Ser Ser Leu Gly Thr Tyr His Asp 
        595                 600                 605             


Leu Arg Lys Ile Leu Asn Lys Ser Phe Leu Asp Asn Lys Glu Asn Glu 
    610                 615                 620                 


Gln Ile Ile Glu Asp Ile Ile Gln Thr Leu Thr Leu Phe Glu Asp Arg 
625                 630                 635                 640 


Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr Ser Asp Ile Phe Thr Lys 
                645                 650                 655     


Ala Gln Leu Lys Lys Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg 
            660                 665                 670         


Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Asn Lys 
        675                 680                 685             


Thr Ile Leu Gly Tyr Leu Ile Asp Asp Gly Tyr Ser Asn Arg Asn Phe 
    690                 695                 700                 


Met Gln Leu Ile Asn Asp Asp Ala Leu Ser Phe Lys Glu Glu Ile Ala 
705                 710                 715                 720 


Lys Ala Gln Val Ile Gly Glu Met Asp Gly Leu Asn Gln Val Val Ser 
                725                 730                 735     


Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Leu 
            740                 745                 750         


Lys Ile Val Asp Glu Leu Val Lys Val Met Gly His Asn Pro Ala Asn 
        755                 760                 765             


Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Ala Lys Gly Arg 
    770                 775                 780                 


Arg Ser Ser Gln Lys Arg Tyr Lys Arg Leu Glu Glu Ala Ile Lys Asn 
785                 790                 795                 800 


Leu Asp His Asp Leu Asn His Lys Ile Leu Lys Glu His Pro Thr Asp 
                805                 810                 815     


Asn Gln Ala Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu Gln Asn 
            820                 825                 830         


Gly Arg Asp Met Tyr Thr Glu Asp Pro Leu Asp Ile Asn Arg Leu Ser 
        835                 840                 845             


Asp Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys Asp Asn 
    850                 855                 860                 


Ser Ile Asp Asn Arg Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys 
865                 870                 875                 880 


Ser Asp Asp Val Pro Ser Glu Glu Val Val His Lys Met Lys Pro Phe 
                885                 890                 895     


Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp 
            900                 905                 910         


Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp Lys Ala 
        915                 920                 925             


Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His 
    930                 935                 940                 


Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp Glu Asn 
945                 950                 955                 960 


Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser Asn Leu 
                965                 970                 975     


Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile 
            980                 985                 990         


Asn Asp Tyr His His Ala His Asp  Ala Tyr Leu Asn Ala  Val Ile Gly 
        995                 1000                 1005             


Lys Ala  Leu Leu Gly Val Tyr  Pro Gln Leu Glu Pro  Glu Phe Val 
    1010                 1015                 1020             


Tyr Gly  Asp Tyr Pro His Phe  His Gly His Lys Glu  Asn Lys Ala 
    1025                 1030                 1035             


Thr Ala  Lys Lys Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1040                 1045                 1050             


Lys Gly  Asp Val Arg Thr Asp  Lys Asn Gly Glu Ile  Ile Trp Lys 
    1055                 1060                 1065             


Lys Asp  Glu His Ile Ser Asn  Ile Lys Lys Val Leu  Ser Tyr Pro 
    1070                 1075                 1080             


Gln Val  Asn Ile Val Lys Lys  Val Glu Glu Gln Thr  Gly Gly Phe 
    1085                 1090                 1095             


Ser Lys  Glu Ser Ile Leu Pro  Lys Gly Asn Ser Asp  Lys Leu Ile 
    1100                 1105                 1110             


Pro Arg  Lys Thr Lys Lys Phe  Tyr Trp Asp Thr Lys  Lys Tyr Gly 
    1115                 1120                 1125             


Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser Ile Leu  Val Ile Ala 
    1130                 1135                 1140             


Asp Ile  Glu Lys Gly Lys Ser  Lys Lys Leu Lys Thr  Val Lys Ala 
    1145                 1150                 1155             


Leu Val  Gly Val Thr Ile Met  Glu Lys Met Thr Phe  Glu Arg Asp 
    1160                 1165                 1170             


Pro Val  Ala Phe Leu Glu Arg  Lys Gly Tyr Arg Asn  Val Gln Glu 
    1175                 1180                 1185             


Glu Asn  Ile Ile Lys Leu Pro  Lys Tyr Ser Leu Phe  Lys Leu Glu 
    1190                 1195                 1200             


Asn Gly  Arg Lys Arg Leu Leu  Ala Ser Ala Arg Glu  Leu Gln Lys 
    1205                 1210                 1215             


Gly Asn  Glu Ile Val Leu Pro  Asn His Leu Glu Thr  Leu Leu Tyr 
    1220                 1225                 1230             


His Ala  Lys Asn Ile His Lys  Val Asp Glu Pro Lys  His Leu Asp 
    1235                 1240                 1245             


Tyr Val  Asp Lys His Lys Asp  Glu Phe Lys Glu Leu  Leu Asp Val 
    1250                 1255                 1260             


Val Ser  Asn Phe Ser Lys Lys  Tyr Thr Leu Ala Glu  Gly Asn Leu 
    1265                 1270                 1275             


Glu Lys  Ile Lys Glu Leu Tyr  Ala Gln Asn Asn Gly  Glu Asp Leu 
    1280                 1285                 1290             


Lys Glu  Leu Ala Ser Ser Phe  Ile Asn Leu Leu Thr  Phe Thr Ala 
    1295                 1300                 1305             


Ile Gly  Ala Pro Ala Ala Phe  Lys Phe Phe Asp Lys  Asn Ile Asp 
    1310                 1315                 1320             


Arg Lys  Arg Tyr Thr Ser Thr  Thr Glu Ile Leu Asn  Ala Thr Leu 
    1325                 1330                 1335             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1340                 1345                 1350             


Asn Lys  Leu Gly Gly Asp 
    1355                 


<210>  605
<211>  1345
<212>  PRT
<213>  Streptococcus mutans NLML9

<400>  605

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Ser Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Thr His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  606
<211>  1345
<212>  PRT
<213>  Streptococcus mutans 4VF1

<400>  606

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Arg Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  607
<211>  1345
<212>  PRT
<213>  Streptococcus mutans N66

<400>  607

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Leu Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Gly Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Phe  Lys Glu Ser Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  608
<211>  1374
<212>  PRT
<213>  Streptococcus pseudoporcinus LQ 940-04

<400>  608

Met Lys Lys Arg Tyr Ser Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn 
1               5                   10                  15      


Ser Val Gly Trp Ala Val Ile Asn Glu Asp Tyr Lys Val Pro Ala Lys 
            20                  25                  30          


Lys Met Thr Val Phe Gly Asn Thr Asp Arg Lys Thr Ile Lys Lys Asn 
        35                  40                  45              


Leu Leu Gly Thr Val Leu Phe Asp Ser Gly Glu Thr Ala Gln Ala Arg 
    50                  55                  60                  


Arg Leu Lys Arg Thr Asn Arg Arg Arg Tyr Thr Arg Arg Arg Tyr Arg 
65                  70                  75                  80  


Leu Cys Gln Leu Gln Asn Ile Phe Ala Thr Glu Met Val Lys Val Asp 
                85                  90                  95      


Asp Thr Phe Phe Gln Arg Leu Ser Glu Ser Phe Phe Tyr Tyr Gln Asp 
            100                 105                 110         


Lys Ala Phe Asp Lys His Pro Ile Phe Gly Asn Ser Lys Glu Glu Arg 
        115                 120                 125             


Ala Tyr His Lys Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Asp Leu 
    130                 135                 140                 


Ala Asp Arg Asp Gln Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu 
145                 150                 155                 160 


Ser His Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Leu 
                165                 170                 175     


Asn Ser Glu Asn Thr Asp Val Gln Lys Leu Phe Ile Ala Leu Val Thr 
            180                 185                 190         


Val Tyr Asn Leu Leu Phe Glu Glu Glu Pro Ile Ala Gly Glu Thr Cys 
        195                 200                 205             


Asp Ala Lys Ala Leu Leu Thr Ala Lys Thr Ser Lys Ser Lys Arg Leu 
    210                 215                 220                 


Glu Ser Leu Ile Ser Glu Phe Pro Gly Gln Lys Lys Asn Gly Leu Phe 
225                 230                 235                 240 


Gly Asn Leu Leu Ala Leu Ala Leu Gly Leu Arg Pro Asn Phe Lys Ser 
                245                 250                 255     


Asn Phe Gly Leu Ser Glu Asp Ala Lys Leu Gln Ile Thr Lys Asp Thr 
            260                 265                 270         


Tyr Glu Glu Glu Leu Asp Asn Leu Leu Ala Glu Ile Gly Asp His Tyr 
        275                 280                 285             


Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu 
    290                 295                 300                 


Ser Asp Ile Leu Thr Leu Ser Asp Glu Asn Thr Arg Ala Pro Leu Ser 
305                 310                 315                 320 


Ala Ser Met Ile Lys Arg Tyr Glu Glu His Gln Glu Asp Leu Ala Leu 
                325                 330                 335     


Leu Lys Lys Leu Val Lys Glu Gln Met Pro Glu Lys Tyr Trp Glu Ile 
            340                 345                 350         


Phe Ser Asn Ala Lys Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Gly Lys 
        355                 360                 365             


Val Ser Gln Glu Asp Phe Tyr Arg Tyr Ile Lys Pro Ile Leu Ser Arg 
    370                 375                 380                 


Leu Lys Gly Gly Asp Glu Phe Leu Ala Lys Ile Asp Arg Asp Asp Phe 
385                 390                 395                 400 


Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile 
                405                 410                 415     


His Leu Lys Glu Leu His Ala Ile Leu Arg Arg Gln Glu Lys Tyr Tyr 
            420                 425                 430         


Pro Phe Leu Ala Glu Gln Lys Glu Lys Ile Glu Gln Leu Leu Cys Phe 
        435                 440                 445             


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Gly Gly Asn Ser Ser 
    450                 455                 460                 


Phe Ala Trp Leu Lys Arg Arg Ser Asp Glu Pro Ile Thr Pro Trp Asn 
465                 470                 475                 480 


Phe Lys Asp Val Val Asp Glu Glu Ala Ser Ala Gln Ala Phe Ile Glu 
                485                 490                 495     


Gly Met Thr Asn Tyr Asp Thr Tyr Leu Pro Glu Glu Lys Val Leu Pro 
            500                 505                 510         


Lys His Ser Pro Leu Tyr Glu Met Phe Thr Val Tyr Asn Glu Leu Thr 
        515                 520                 525             


Lys Val Lys Tyr Ile Ala Glu Asn Met Thr Lys Pro Leu Tyr Leu Ser 
    530                 535                 540                 


Ala Glu Gln Lys Glu Ala Ile Ile Asp His Leu Phe Lys Gln Thr Arg 
545                 550                 555                 560 


Lys Val Thr Val Lys Asp Leu Lys Glu Lys Tyr Phe Ser Gln Ile Glu 
                565                 570                 575     


Gly Leu Glu Asn Val Asp Val Thr Gly Val Glu Gly Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr Asn Asp Leu Leu Lys Ile Ile Lys Asp Lys Ala 
        595                 600                 605             


Phe Leu Asp Asp Glu Ala Asn Ala Glu Ile Leu Glu Glu Ile Val Leu 
    610                 615                 620                 


Ile Leu Thr Leu Phe Gln Asp Glu Lys Leu Ile Glu Lys Arg Leu Ala 
625                 630                 635                 640 


Lys Tyr Ala Asn Leu Phe Glu Lys Ser Val Leu Lys Lys Leu Arg Lys 
                645                 650                 655     


Arg His Tyr Arg Gly Trp Gly Arg Leu Ser Arg Gln Leu Ile Asp Gly 
            660                 665                 670         


Met Lys Asp Lys Ala Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ala 
        675                 680                 685             


Asp Asp Phe Ala Asn Arg Asn Phe Ile Gln Leu Ile Asn Asp Ser Ser 
    690                 695                 700                 


Leu Asp Phe Glu Lys Leu Ile Asp Asp Ala Gln Lys Lys Ala Ile Lys 
705                 710                 715                 720 


Arg Glu Ser Leu Thr Glu Ala Val Ala Asn Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Val Val Asp Glu Ile Val 
            740                 745                 750         


Lys Val Met Gly His Asn Pro Asp Asn Ile Val Ile Glu Met Ser Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Ala Gln Gly Leu Lys Asn Ala Arg Gln Arg Leu 
    770                 775                 780                 


Lys Lys Ile Lys Glu Val His Lys Lys Thr Gly Ser Arg Ile Leu Glu 
785                 790                 795                 800 


Asp Asn Ser Glu Arg Ile Thr Asn Leu Thr Leu Gln Asp Asn Arg Leu 
                805                 810                 815     


Tyr Leu Tyr Leu Leu Gln Asp Gly Lys Asp Met Tyr Thr Gly Gln Asp 
            820                 825                 830         


Leu Asp Ile Asn Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ser Phe Ile Lys Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Thr 
    850                 855                 860                 


Gln Lys Ala Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Glu Val 
865                 870                 875                 880 


Val Arg Asp Met Lys Asp Arg Val Trp Arg Arg Gln Leu Ala Asn Gly 
                885                 890                 895     


Ala Ile Ser Arg Gln Lys Phe Asp His Leu Thr Lys Ala Glu Arg Gly 
            900                 905                 910         


Gly Leu Ala Asp Ser Asp Lys Ala Arg Phe Leu Arg Arg Gln Leu Val 
        915                 920                 925             


Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Leu Leu Asp Ser Arg 
    930                 935                 940                 


Phe Asn Ser Lys Ser Asn Gln Asn Lys Lys Leu Ala Arg Asn Val Lys 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ser Lys Ile Val Ser Asp Phe Arg Lys Asp Phe 
                965                 970                 975     


Gly Leu Tyr Lys Leu Arg Glu Val Asn Asn Tyr His His Ala His Asp 
            980                 985                 990         


Ala Tyr Leu Asn Ala Val Val Gly  Thr Ala Leu Leu Lys  Lys Tyr Pro 
        995                 1000                 1005             


Lys Leu  Glu Ala Glu Phe Val  Tyr Gly Asp Tyr Lys  His Phe Asp 
    1010                 1015                 1020             


Leu Val  Lys Leu Ile Ser Lys  Ser Asp Pro Ser Leu  Gly Lys Ala 
    1025                 1030                 1035             


Thr Ala  Lys Val Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1040                 1045                 1050             


Glu Glu  Leu Ser Leu Ala Asp  Gly Thr Leu Met Lys  Arg Pro Val 
    1055                 1060                 1065             


Ile Glu  Thr Asn Thr Glu Thr  Gly Glu Val Val Trp  Asp Lys Val 
    1070                 1075                 1080             


Lys Asp  Phe Lys Thr Ile Arg  Lys Val Leu Ser Tyr  Pro Gln Val 
    1085                 1090                 1095             


Asn Ile  Val Lys Lys Thr Glu  Ile Gln Ser Gly Ala  Phe Ser Lys 
    1100                 1105                 1110             


Glu Ser  Val Leu Ser Lys Gly  Asn Ser Asp Lys Leu  Ile Glu Arg 
    1115                 1120                 1125             


Lys Lys  Gly Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1130                 1135                 1140             


Asn Thr  Ala Tyr Ser Ile Phe  Val Val Ala Lys Val  Ala Lys Arg 
    1145                 1150                 1155             


Lys Ala  Gln Lys Leu Lys Thr  Val Lys Glu Ile Val  Gly Ile Thr 
    1160                 1165                 1170             


Ile Met  Glu Gln Ala Glu Tyr  Glu Lys Asp Asn Ile  Ala Phe Leu 
    1175                 1180                 1185             


Glu Lys  Lys Gly Tyr Gln Asp  Ile Gln Glu Lys Leu  Leu Ile Lys 
    1190                 1195                 1200             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg 
    1205                 1210                 1215             


Leu Leu  Ala Ser Ala Asn Glu  Phe Gln Lys Gly Asn  Glu Leu Ala 
    1220                 1225                 1230             


Leu Ser  Gly Lys Tyr Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr 
    1235                 1240                 1245             


Asp Lys  Leu Ser Ser Lys Ile  Glu Ser Glu Gln Gln  Lys Lys Leu 
    1250                 1255                 1260             


Phe Val  Glu Gln His Leu His  Tyr Phe Asp Glu Ile  Leu Asp Ile 
    1265                 1270                 1275             


Val Val  Lys His Ala Thr Cys  Tyr Ile Lys Ala Glu  Asn Asn Leu 
    1280                 1285                 1290             


Lys Lys  Ile Ile Ser Leu Tyr  Lys Lys Lys Glu Ala  Tyr Ser Ile 
    1295                 1300                 1305             


Asn Glu  Gln Ala Leu Asn Met  Leu Asn Leu Phe Ile  Phe Thr Ser 
    1310                 1315                 1320             


Leu Gly  Ala Pro Ser Thr Phe  Val Phe Phe Asp Glu  Thr Ile Asp 
    1325                 1330                 1335             


Arg Lys  Arg Tyr Thr Thr Ser  Ser Asp Val Leu Asn  Gly Ile Leu 
    1340                 1345                 1350             


Ile Gln  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1355                 1360                 1365             


Ser Arg  Phe Gly Gly Asp 
    1370                 


<210>  609
<211>  1345
<212>  PRT
<213>  Streptococcus mutans 11VS1

<400>  609

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  610
<211>  1229
<212>  PRT
<213>  Streptococcus mutans SA38

<400>  610

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Ile Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Thr Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Pro Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Glu  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Ile Gly 
    1070                 1075                 1080             


Gln Asn  Gly Gly Leu Phe Asp  Asp Asn Pro Lys Ser  Pro Leu Glu 
    1085                 1090                 1095             


Val Ile  Pro Ser Lys Leu Val  Pro Leu Lys Lys Ala  Leu Asn Pro 
    1100                 1105                 1110             


Glu Lys  Tyr Gly Gly Tyr Gln  Lys Pro Thr Thr Ala  Tyr Pro Ile 
    1115                 1120                 1125             


Leu Leu  Ile Val Asp Thr Lys  Gln Leu Ile Pro Ile  Ser Val Met 
    1130                 1135                 1140             


Asp Lys  Lys Arg Phe Glu Gln  Asn Pro Val Lys Phe  Leu Lys Asp 
    1145                 1150                 1155             


Lys Gly  Tyr Gln Gln Ile Glu  Lys Asn Asn Phe Val  Lys Leu Pro 
    1160                 1165                 1170             


Lys Tyr  Thr Leu Val Asp Ile  Gly Asn Gly Ile Lys  Arg Leu Trp 
    1175                 1180                 1185             


Ala Ser  Ser Lys Glu Val His  Lys Gly Asn Gln Leu  Val Val Ser 
    1190                 1195                 1200             


Lys Lys  Ser Gln Asp Leu Leu  Tyr His Ala His His  Leu Asp Asn 
    1205                 1210                 1215             


Asp Tyr  Ser Asn Glu Tyr Val  Lys Asn His Tyr 
    1220                 1225                 


<210>  611
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes A20

<400>  611

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  612
<211>  1345
<212>  PRT
<213>  Streptococcus mutans A9

<400>  612

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Gly Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  613
<211>  1345
<212>  PRT
<213>  Streptococcus mutans SM4

<400>  613

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Asp Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  614
<211>  1345
<212>  PRT
<213>  Streptococcus mutans KK21

<400>  614

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Asn  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  615
<211>  1345
<212>  PRT
<213>  Streptococcus mutans M21

<400>  615

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  616
<211>  611
<212>  PRT
<213>  Streptococcus dysgalactiae subsp. equisimilis SK1249

<400>  616

Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys 
1               5                   10                  15      


Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr 
            20                  25                  30          


Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln 
        35                  40                  45              


Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln 
    50                  55                  60                  


Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser 
65                  70                  75                  80  


Asp Ala Thr Leu Leu Ser Asp Ile Leu Arg Val Asn Ser Glu Ile Thr 
                85                  90                  95      


Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His 
            100                 105                 110         


Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu 
        115                 120                 125             


Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly 
    130                 135                 140                 


Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys 
145                 150                 155                 160 


Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Ala Lys Leu 
                165                 170                 175     


Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser 
            180                 185                 190         


Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg 
        195                 200                 205             


Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu 
    210                 215                 220                 


Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg 
225                 230                 235                 240 


Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile 
                245                 250                 255     


Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln 
            260                 265                 270         


Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu 
        275                 280                 285             


Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr 
    290                 295                 300                 


Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro 
305                 310                 315                 320 


Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe 
                325                 330                 335     


Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe 
            340                 345                 350         


Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp 
        355                 360                 365             


Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile 
    370                 375                 380                 


Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu 
385                 390                 395                 400 


Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Lys Glu Met Ile Glu 
                405                 410                 415     


Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys 
            420                 425                 430         


Gln Leu Lys Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys 
        435                 440                 445             


Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp 
    450                 455                 460                 


Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Ile Gln Leu Ile 
465                 470                 475                 480 


His Asp Asp Ser Leu Thr Phe Lys Glu Ala Ile Gln Lys Ala Gln Val 
                485                 490                 495     


Ser Gly Gln Gly His Ser Leu His Glu Gln Ile Ala Asn Leu Ala Gly 
            500                 505                 510         


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Val Lys Val Val Asp 
        515                 520                 525             


Glu Leu Val Lys Val Met Gly His Lys Pro Glu Asn Ile Val Ile Glu 
    530                 535                 540                 


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
545                 550                 555                 560 


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
                565                 570                 575     


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
            580                 585                 590         


Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln 
        595                 600                 605             


Glu Leu Asp 
    610     


<210>  617
<211>  213
<212>  PRT
<213>  Streptococcus dysgalactiae subsp. equisimilis SK1249

<400>  617

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Ser Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Lys Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser 
    210             


<210>  618
<211>  1345
<212>  PRT
<213>  Streptococcus mutans U138

<400>  618

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Ile  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  619
<211>  1345
<212>  PRT
<213>  Streptococcus mutans SM1

<400>  619

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Lys Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Leu Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Leu Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Ile Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  620
<211>  1350
<212>  PRT
<213>  Streptococcus mutans ST6

<400>  620

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Thr Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Ser Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val Val Asn Arg Met Arg 
865                 870                 875                 880 


Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu Ile Ser Gln Arg Lys 
                885                 890                 895     


Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Leu Asp Asp Lys Ala Gly 
            900                 905                 910         


Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val 
        915                 920                 925             


Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu Phe Asp Asp Asn Asn 
    930                 935                 940                 


Lys Arg Ile Arg Lys Val Lys Ile Val Thr Leu Lys Ser Asn Leu Val 
945                 950                 955                 960 


Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn 
                965                 970                 975     


Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Val Lys 
            980                 985                 990         


Ala Leu Leu Val Lys Tyr Ser Lys  Leu Glu Pro Glu Phe  Val Tyr Gly 
        995                 1000                 1005             


Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu Arg Lys  Thr Ala Thr 
    1010                 1015                 1020             


Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met Asn Met  Phe Lys Ser 
    1025                 1030                 1035             


Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val Glu Arg  Pro Met Ile 
    1040                 1045                 1050             


Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala Trp Asp  Lys Thr Lys 
    1055                 1060                 1065             


His Ile  Thr Thr Val Lys Lys  Val Leu Ser Tyr Pro  Gln Val Asn 
    1070                 1075                 1080             


Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile Gly Gln  Asn Gly Gly 
    1085                 1090                 1095             


Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu Glu Val  Ile Pro Ser 
    1100                 1105                 1110             


Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn Pro Glu  Lys Tyr Gly 
    1115                 1120                 1125             


Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro Ile Leu  Leu Ile Val 
    1130                 1135                 1140             


Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val Met Asp  Lys Lys Arg 
    1145                 1150                 1155             


Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys Asp Lys  Gly Tyr Gln 
    1160                 1165                 1170             


Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu Pro Lys  Tyr Thr Leu 
    1175                 1180                 1185             


Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu Trp Ala  Ser Ser Lys 
    1190                 1195                 1200             


Glu Val  His Lys Gly Asn Gln  Leu Val Val Ser Lys  Lys Ser Gln 
    1205                 1210                 1215             


Asp Leu  Leu Tyr His Ala His  His Leu Asp Asn Asp  Tyr Ser Asn 
    1220                 1225                 1230             


Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe Asp Ile  Leu Phe Asn 
    1235                 1240                 1245             


Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys Leu Gly  Lys Glu His 
    1250                 1255                 1260             


Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys Glu Arg  Asp Ser Ala 
    1265                 1270                 1275             


Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile Lys Leu  Leu Gly Phe 
    1280                 1285                 1290             


Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser Phe Leu  Gly Ile Lys 
    1295                 1300                 1305             


Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys Asp Tyr  Leu Leu Pro 
    1310                 1315                 1320             


Cys Met  Glu Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1325                 1330                 1335             


Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345                 1350 


<210>  621
<211>  1345
<212>  PRT
<213>  Streptococcus mutans 11SSST2

<400>  621

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Thr Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Leu Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Pro Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Glu  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ser Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Ala  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  622
<211>  1381
<212>  PRT
<213>  Streptococcus suis ST1

<400>  622

Met Val Lys Lys Lys Tyr Ala Ile Gly Ile Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ser Ile Val Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Phe Gly Asn Thr Glu Lys Arg Tyr Ile Lys Lys Asn Leu 
        35                  40                  45              


Leu Gly Thr Leu Leu Phe Asp Glu Gly Asn Thr Ala Glu Asn Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Glu Ile Phe Ala Glu Glu Ile Asn Lys Ile Asp Asp 
                85                  90                  95      


Ser Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Ile Val Glu Asp Lys 
            100                 105                 110         


Gln Gly Ser Lys His Pro Ile Phe Gly Thr Leu Gln Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala 
    130                 135                 140                 


Asp Ser Ser Gln Lys Ala Asp Ile Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Ile Ile Lys Tyr Arg Gly His Phe Leu Phe Glu Gly Asp Leu Lys 
                165                 170                 175     


Ser Glu Asn Lys Asp Val Gln His Leu Phe Asn Asp Phe Val Glu Met 
            180                 185                 190         


Phe Asp Lys Thr Val Glu Gly Ser Tyr Leu Ser Glu Asn Leu Pro Asn 
        195                 200                 205             


Val Ala Asp Val Leu Val Glu Lys Val Ser Lys Ser Arg Arg Leu Glu 
    210                 215                 220                 


Asn Ile Leu His Tyr Phe Pro Asn Glu Lys Lys Asn Gly Leu Phe Gly 
225                 230                 235                 240 


Asn Phe Leu Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn 
                245                 250                 255     


Phe Glu Leu Ala Glu Asp Ala Lys Ile Gln Phe Ser Lys Glu Thr Tyr 
            260                 265                 270         


Glu Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala 
        275                 280                 285             


Asp Leu Phe Ile Ala Thr Lys Ser Leu Tyr Asp Gly Ile Leu Leu Ala 
    290                 295                 300                 


Gly Ile Leu Ser Thr Thr Asp Ser Thr Thr Lys Ala Pro Leu Ser Ser 
305                 310                 315                 320 


Ser Met Val Asn Arg Tyr Glu Glu His Gln Lys Asp Leu Ala Leu Leu 
                325                 330                 335     


Lys Asn Phe Ile His Gln Asn Leu Ser Asp Ser Tyr Lys Glu Val Phe 
            340                 345                 350         


Asn Asp Lys Leu Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Asn Phe Tyr Arg Phe Ile Lys Lys Ala Ile Glu Lys Ile 
    370                 375                 380                 


Glu Gly Ser Asn Tyr Phe Ile Asp Lys Ile Asp Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met His Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro 
            420                 425                 430         


Phe Leu Val Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Glu Phe Ala 
    450                 455                 460                 


Trp Leu Asn Arg Lys Ser Asp Glu Lys Ile Arg Pro Trp Asn Phe Asp 
465                 470                 475                 480 


Glu Met Val Asp Lys Glu Thr Ser Ala Glu Asn Phe Ile Thr Arg Met 
                485                 490                 495     


Thr Asn Tyr Asp Arg Tyr Leu Pro Asp Gln Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Lys Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Met Arg Asp Tyr Gln Phe Leu Asp Ser Gly 
    530                 535                 540                 


Gln Lys Lys Asp Ile Val Lys Thr Leu Phe Lys Thr Lys Arg Lys Val 
545                 550                 555                 560 


Thr Ala Lys Asp Ile Lys Ala Tyr Leu Glu Asn Ser Asn Gly Tyr Ala 
                565                 570                 575     


Gly Val Glu Leu Lys Gly Leu Glu Glu Gln Phe Asn Ala Ser Leu Pro 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Leu Arg Asp Lys Ala Phe Ile Asp 
        595                 600                 605             


Ala Glu Glu Asn Gln Glu Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Lys Tyr Lys 
625                 630                 635                 640 


Asp Ile Leu Thr Glu Glu Gln Arg Lys Lys Leu Glu Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Leu Asp 
            660                 665                 670         


Lys Val Thr Arg Lys Thr Ile Leu Gly Tyr Leu Ile Asp Asp Gly Thr 
        675                 680                 685             


Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Thr Leu Ser Phe 
    690                 695                 700                 


Val Asp Glu Ile Arg Leu Ala Gln Gly Ser Gly Glu Ala Glu Asp Tyr 
705                 710                 715                 720 


Arg Ala Glu Val Gln Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Ile Glu Val Met Gly 
            740                 745                 750         


Tyr Glu Pro Glu His Ile Val Val Glu Met Ala Arg Glu Asn Gln Phe 
        755                 760                 765             


Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Ile Asn Arg Leu Glu 
    770                 775                 780                 


Asn Ala Leu Lys Asp Phe Gly Ser Lys Ile Leu Glu Glu Gln Lys Pro 
785                 790                 795                 800 


Tyr Gly Val Ser Lys Val Asn Asn Ile His Leu Gln Ser Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Asp Glu Glu 
            820                 825                 830         


Leu Asp Ile Asp His Leu Ser Glu Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Leu Asp Asn Lys Val Leu Thr Lys 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Met Glu Ile 
865                 870                 875                 880 


Val His Asn Arg Lys Asn Phe Trp Arg Gln Leu Leu Lys Ser Lys Leu 
                885                 890                 895     


Ile Ser Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Asn Glu Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Met Leu Asp Thr Arg Phe 
    930                 935                 940                 


Asn Thr Lys Leu Asp Glu Ala Gly Asn Arg Ile Arg Asp Pro Lys Val 
945                 950                 955                 960 


Asn Ile Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe Arg Lys Asp 
                965                 970                 975     


Tyr Gln Leu Tyr Lys Ile Arg Glu Ile Asn Asn Tyr His His Ala His 
            980                 985                 990         


Asp Ala Tyr Ile Asn Ala Val Val  Ala Thr Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Gln  Leu Ala Pro Glu Phe  Val Tyr Gly Glu Tyr  Pro Thr Tyr 
    1010                 1015                 1020             


Asn Ser  Tyr Asn Ser Arg Lys  Ser Ala Thr Glu Lys  Val Leu Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Arg Ile Val  Val His Ser 
    1040                 1045                 1050             


Lys Thr  Gly Glu Val Arg Ile  Arg Pro Val Ile Glu  Val Asn Lys 
    1055                 1060                 1065             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Lys Ser Asp  Phe Arg Thr 
    1070                 1075                 1080             


Val Arg  Lys Val Leu Ser Tyr  Pro Gln Val Asn Val  Val Lys Lys 
    1085                 1090                 1095             


Thr Glu  Val Gln Asn His Gly  Leu Asp Arg Gly Lys  Pro Lys Gly 
    1100                 1105                 1110             


Phe Tyr  Asn Ala Asn Leu Ser  Pro Arg Pro Lys Glu  Gly Ser Val 
    1115                 1120                 1125             


Glu Asn  Leu Val Pro Ala Lys  Gln Ser Phe Asp Thr  Lys Arg Tyr 
    1130                 1135                 1140             


Gly Gly  Tyr Ala Gly Ile Ser  Asn Ser Tyr Ala Val  Leu Val Asn 
    1145                 1150                 1155             


Gly Ile  Ile Glu Lys Gly Lys  Lys Lys Ser Lys Ala  Glu Val Thr 
    1160                 1165                 1170             


Glu Phe  Gln Gly Ile Ser Ile  Leu Ala Arg Lys Asp  Phe Asp Lys 
    1175                 1180                 1185             


Asn Pro  Lys Gln Tyr Leu Leu  Asn Leu Gly Tyr Lys  Asp Ile Lys 
    1190                 1195                 1200             


Ser Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn 
    1205                 1210                 1215             


Gly Ser  Arg Arg Met Leu Ala  Ser Ile Leu Ser Thr  Asn Asn Lys 
    1220                 1225                 1230             


Arg Gly  Glu Ile His Lys Gly  Asn Glu Met Tyr Leu  Pro Asp Lys 
    1235                 1240                 1245             


Phe Val  Thr Leu Leu Tyr His  Ala Met Arg Val Asn  Arg Thr Leu 
    1250                 1255                 1260             


Glu Pro  Gly His Lys Lys Tyr  Val Glu Thr His Arg  His Val Phe 
    1265                 1270                 1275             


Asp Glu  Leu Leu Ile Tyr Ile  Leu Glu Tyr Asn Glu  Lys Ile Val 
    1280                 1285                 1290             


Gly Ala  Lys Ala Asn Gly Lys  Arg Ile Val Glu Ala  Tyr Ser Ala 
    1295                 1300                 1305             


Arg Lys  Asp Thr Asp Asn Leu  Glu Glu Leu Cys Asn  Ser Phe Ile 
    1310                 1315                 1320             


Asn Leu  Leu Asn Leu Thr Ala  Leu Gly Ser Ala Val  Asp Phe Glu 
    1325                 1330                 1335             


Phe Leu  Gly Thr Lys Ile Pro  Arg Tyr Arg Asp Tyr  Thr Pro Ser 
    1340                 1345                 1350             


Ser Leu  Leu Lys Ala Thr Leu  Ile His Gln Ser Val  Thr Gly Leu 
    1355                 1360                 1365             


Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu Gly Gly  Asp 
    1370                 1375                 1380     


<210>  623
<211>  1345
<212>  PRT
<213>  Streptococcus mutans G123

<400>  623

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  624
<211>  1345
<212>  PRT
<213>  Streptococcus mutans NV1996

<400>  624

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  625
<211>  1345
<212>  PRT
<213>  Streptococcus mutans AC4446

<400>  625

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  626
<211>  1368
<212>  PRT
<213>  Streptococcus iniae 9117

<400>  626

Met Arg Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Arg Ile Gln Gly Thr Thr Asp Arg Thr Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Asn Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Thr Arg Arg Arg Tyr Thr Arg Arg Lys Tyr Arg Ile Lys 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ser Ser Glu Met Asn Glu Leu Asp Ile Ala 
                85                  90                  95      


Phe Phe Pro Arg Leu Ser Glu Ser Phe Leu Val Ser Asp Asp Lys Glu 
            100                 105                 110         


Phe Glu Asn His Pro Ile Phe Gly Asn Leu Lys Asp Glu Ile Thr Tyr 
        115                 120                 125             


His Asn Asp Tyr Pro Thr Ile Tyr His Leu Arg Gln Thr Leu Ala Asp 
    130                 135                 140                 


Ser Asp Gln Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asn Leu Asp Ser 
                165                 170                 175     


Glu Asn Thr Asp Val His Val Leu Phe Leu Asn Leu Val Asn Ile Tyr 
            180                 185                 190         


Asn Asn Leu Phe Glu Glu Asp Ile Val Glu Thr Ala Ser Ile Asp Ala 
        195                 200                 205             


Glu Lys Ile Leu Thr Ser Lys Thr Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Glu Ile Pro Asn Gln Lys Arg Asn Met Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Val Ser Leu Ala Leu Gly Leu Thr Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Glu Leu Leu Glu Asp Ala Lys Leu Gln Ile Ser Lys Asp Ser Tyr Glu 
            260                 265                 270         


Glu Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ile Ala Ala Lys Lys Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Ile Thr Val Lys Gly Ala Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Gln Arg Tyr Glu Glu His Gln Gln Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Asn Leu Val Lys Lys Gln Ile Pro Glu Lys Tyr Lys Glu Ile Phe Asp 
            340                 345                 350         


Asn Lys Glu Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Tyr Ile Lys Pro Ile Leu Leu Lys Leu Asp 
    370                 375                 380                 


Gly Thr Glu Lys Leu Ile Ser Lys Leu Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Asn Glu Leu Lys Ala Ile Ile Arg Arg Gln Glu Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Lys Lys Ile Glu Lys Leu Phe Thr Phe Lys Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Asn Gly Gln Ser Ser Phe Ala Trp 
    450                 455                 460                 


Leu Lys Arg Gln Ser Asn Glu Ser Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Gln Glu Ala Ser Ala Arg Ala Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Thr Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Pro Leu Tyr Glu Met Phe Met Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Gln Thr Glu Gly Met Lys Arg Pro Val Phe Leu Ser Ser Glu Asp 
    530                 535                 540                 


Lys Glu Glu Ile Val Asn Leu Leu Phe Lys Lys Glu Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Glu Tyr Phe Ser Lys Met Lys Cys Phe His 
                565                 570                 575     


Thr Val Thr Ile Leu Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Phe Lys Asp Lys Ala Phe Leu Asp 
        595                 600                 605             


Asp Glu Ala Asn Gln Asp Ile Leu Glu Glu Ile Val Trp Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Gln Ala Met Ile Glu Arg Arg Leu Val Lys Tyr Ala 
625                 630                 635                 640 


Asp Val Phe Glu Lys Ser Val Leu Lys Lys Leu Lys Lys Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Gln Lys Leu Ile Asn Gly Ile Lys Asp 
            660                 665                 670         


Lys Gln Thr Gly Lys Thr Ile Leu Gly Phe Leu Lys Asp Asp Gly Val 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Ser Ser Leu Asp Phe 
    690                 695                 700                 


Ala Lys Ile Ile Lys Asn Glu Gln Glu Lys Thr Ile Lys Asn Glu Ser 
705                 710                 715                 720 


Leu Glu Glu Thr Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Ile Val Lys Ile Met 
            740                 745                 750         


Gly Gln Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Ser Thr Met Gln Gly Ile Lys Asn Ser Arg Gln Arg Leu Arg Lys Leu 
    770                 775                 780                 


Glu Glu Val His Lys Asn Thr Gly Ser Lys Ile Leu Lys Glu Tyr Asn 
785                 790                 795                 800 


Val Ser Asn Thr Gln Leu Gln Ser Asp Arg Leu Tyr Leu Tyr Leu Leu 
                805                 810                 815     


Gln Asp Gly Lys Asp Met Tyr Thr Gly Lys Glu Leu Asp Tyr Asp Asn 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Thr Val Leu Thr Thr Gln Ala Ser Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Asn Ile Glu Thr Val Asn Lys Met Lys 
865                 870                 875                 880 


Ser Phe Trp Tyr Lys Gln Leu Lys Ser Gly Ala Ile Ser Gln Arg Lys 
                885                 890                 895     


Phe Asp His Leu Thr Lys Ala Glu Arg Gly Ala Leu Ser Asp Phe Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Phe Asn Ser Asn Leu Thr 
    930                 935                 940                 


Glu Asp Ser Lys Ser Asn Arg Asn Val Lys Ile Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Met Val Ser Asp Phe Arg Lys Asp Phe Gly Phe Tyr Lys Leu Arg 
                965                 970                 975     


Glu Val Asn Asp Tyr His His Ala Gln Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Leu Lys Lys  Tyr Pro Lys Leu Glu  Ala Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys His  Tyr Asp Leu Ala Lys  Leu Met Ile 
    1010                 1015                 1020             


Gln Pro  Asp Ser Ser Leu Gly  Lys Ala Thr Thr Arg  Met Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Leu Met Asn Phe  Phe Lys Lys Glu Ile  Lys Leu Ala 
    1040                 1045                 1050             


Asp Asp  Thr Ile Phe Thr Arg  Pro Gln Ile Glu Val  Asn Thr Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Val Lys Asp Met  Gln Thr Ile 
    1070                 1075                 1080             


Arg Lys  Val Met Ser Tyr Pro  Gln Val Asn Ile Val  Met Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Trp Pro Lys 
    1100                 1105                 1110             


Gly Asp  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Ser  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Ile Ile Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Ile Ala  Lys Gly Lys Thr Gln  Lys Leu Lys 
    1145                 1150                 1155             


Thr Ile  Lys Glu Leu Val Gly  Ile Lys Ile Met Glu  Gln Asp Glu 
    1160                 1165                 1170             


Phe Glu  Lys Asp Pro Ile Ala  Phe Leu Glu Lys Lys  Gly Tyr Gln 
    1175                 1180                 1185             


Asp Ile  Gln Thr Ser Ser Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Leu Leu Ala  Ser Ala Lys 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Asn  Lys Tyr Val 
    1220                 1225                 1230             


Lys Phe  Leu Tyr Leu Ala Ser  His Tyr Thr Lys Phe  Thr Gly Lys 
    1235                 1240                 1245             


Glu Glu  Asp Arg Glu Lys Lys  Arg Ser Tyr Val Glu  Ser His Leu 
    1250                 1255                 1260             


Tyr Tyr  Phe Asp Glu Ile Met  Gln Ile Ile Val Glu  Tyr Ser Asn 
    1265                 1270                 1275             


Arg Tyr  Ile Leu Ala Asp Ser  Asn Leu Ile Lys Ile  Gln Asn Leu 
    1280                 1285                 1290             


Tyr Lys  Glu Lys Asp Asn Phe  Ser Ile Glu Glu Gln  Ala Ile Asn 
    1295                 1300                 1305             


Met Leu  Asn Leu Phe Thr Phe  Thr Asp Leu Gly Ala  Pro Ser Ala 
    1310                 1315                 1320             


Phe Lys  Phe Phe Asn Gly Asp  Ile Asp Arg Lys Arg  Tyr Ser Ser 
    1325                 1330                 1335             


Thr Asn  Glu Ile Ile Asn Ser  Thr Leu Ile Tyr Gln  Ser Pro Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Lys Leu  Gly Gly Lys 
    1355                 1360                 1365             


<210>  627
<211>  1345
<212>  PRT
<213>  Streptococcus constellatus subsp. constellatus SK53

<400>  627

Met Gly Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Gln Ser Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Thr Gly Glu Met Asn Lys Val Asp Glu Asn 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Asp Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu His His Pro Ile Phe Gly Asn Ile Ala Ala Glu Val Lys Tyr 
        115                 120                 125             


His Asp Asp Phe Pro Thr Ile Tyr His Leu Arg Arg His Leu Ala Asp 
    130                 135                 140                 


Thr Ser Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Tyr Glu Gly Asp Leu Lys Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Ala Leu Phe Lys Asp Phe Val Glu Glu Tyr 
            180                 185                 190         


Asp Lys Thr Ile Glu Glu Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Ser Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala His Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Asp Leu His Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Gly Phe Leu Gly Glu Val Gly Asp Glu Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Glu Glu His Gln Lys Asp Leu Lys Lys Leu Lys 
                325                 330                 335     


Asp Phe Ile Lys Val Asn Ala Pro Asp Gln Tyr Asn Ala Ile Phe Lys 
            340                 345                 350         


Asp Lys Asn Lys Lys Gly Tyr Ala Ser Tyr Ile Glu Ser Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Gly Ile Leu Leu Lys Ile Asn 
    370                 375                 380                 


Gly Ser Gly Asp Phe Leu Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Gly Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr Lys Ala Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp 
465                 470                 475                 480 


Ile Leu Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr 
                485                 490                 495     


Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Pro Leu Tyr Glu Ala Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Asn Glu Gln Gly Glu Ala Lys Phe Phe Asp Thr Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile 
                565                 570                 575     


Val Asn Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ser Ser 
            580                 585                 590         


Leu Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Ser Phe Leu 
        595                 600                 605             


Asp Asp Lys Ala Asn Glu Lys Thr Ile Glu Asp Ile Ile Gln Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr 
625                 630                 635                 640 


Ser Asp Ile Phe Thr Lys Ala Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Asn Lys Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Tyr Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Arg Ala Gln Ile Ile Asp Asp Val Asp Asp 
705                 710                 715                 720 


Ile Ala Asn Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly His Asn Pro Ala Asn Ile Ile Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Asp Lys Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Leu Leu 
    770                 775                 780                 


Gln Asp Ser Leu Lys Asn Leu Asp Asn Pro Val Asn Ile Lys Asn Val 
785                 790                 795                 800 


Glu Asn Gln Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Ile Gln 
                805                 810                 815     


Asn Gly Lys Asp Met Tyr Thr Gly Glu Thr Leu Asp Ile Asn Asn Leu 
            820                 825                 830         


Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys Asp 
        835                 840                 845             


Asn Ser Leu Asp Asn Arg Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asp Val Pro Ser Ile Glu Val Val His Glu Met Lys Ser 
865                 870                 875                 880 


Phe Trp Ser Lys Leu Leu Ser Val Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Glu Glu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Glu Arg Phe Asn Thr Glu Phe Asp Gly 
    930                 935                 940                 


Asn Lys Arg Arg Ile Arg Asn Val Lys Ile Ile Thr Leu Lys Ser Asn 
945                 950                 955                 960 


Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Asn Ala Leu Leu Leu Lys Tyr  Pro Gln Leu Glu Pro  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Glu Tyr Pro Lys Tyr  Asn Ser Tyr Arg Ser  Arg Lys Ser 
    1010                 1015                 1020             


Ala Thr  Glu Lys Phe Leu Phe  Tyr Ser Asn Ile Leu  Arg Phe Phe 
    1025                 1030                 1035             


Lys Lys  Glu Asp Ile Gln Thr  Asn Glu Asp Gly Glu  Ile Ala Trp 
    1040                 1045                 1050             


Asn Lys  Glu Lys His Ile Lys  Ile Leu Arg Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Glu Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Asn  Ser Tyr Trp Asp Pro  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Val  Val Ala Tyr Ser Ile  Leu Val Phe 
    1115                 1120                 1125             


Ala Asp  Val Glu Lys Gly Lys  Ser Lys Lys Leu Arg  Lys Val Gln 
    1130                 1135                 1140             


Asp Met  Val Gly Ile Thr Ile  Met Glu Lys Lys Arg  Phe Glu Lys 
    1145                 1150                 1155             


Asn Pro  Val Asp Phe Leu Glu  Gln Arg Gly Tyr Arg  Asn Val Arg 
    1160                 1165                 1170             


Leu Glu  Lys Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1175                 1180                 1185             


Glu Asn  Lys Arg Arg Arg Leu  Leu Ala Ser Ala Lys  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Leu Val Ile  Pro Gln Arg Phe Thr  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ser Tyr Arg Ile Glu  Lys Asp Tyr Glu Pro  Glu His Arg 
    1220                 1225                 1230             


Glu Tyr  Val Glu Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Glu 
    1235                 1240                 1245             


Tyr Ile  Ser Val Phe Ser Arg  Lys Tyr Val Leu Ala  Asp Asn Asn 
    1250                 1255                 1260             


Leu Thr  Lys Ile Glu Met Leu  Phe Ser Lys Asn Lys  Asp Ala Glu 
    1265                 1270                 1275             


Val Ser  Ser Leu Ala Lys Ser  Phe Ile Ser Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Phe  Gly Ala Pro Ala Ala  Phe Asn Phe Phe Gly  Glu Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Val Thr Glu Cys Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Glu Asp  
    1340                 1345 


<210>  628
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae CF01173

<400>  628

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  629
<211>  1345
<212>  PRT
<213>  Streptococcus mutans W6

<400>  629

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  630
<211>  1345
<212>  PRT
<213>  Streptococcus mutans GS-5

<400>  630

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Gly Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  631
<211>  1388
<212>  PRT
<213>  Streptococcus thermophilus MN-ZLW-002

<400>  631

Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asn Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Ser Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Val Leu Leu Phe Asp Ser Gly Ile Thr Ala Glu Gly Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Thr Glu Met Ala Thr Leu Asp Asp Ala 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Pro Asp Asp Lys Arg 
            100                 105                 110         


Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val Glu Glu Lys Ala Tyr 
        115                 120                 125             


His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Ser Thr Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Phe Asn Ser 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Asn Phe Gln Asp Phe Leu Asp Thr Tyr 
            180                 185                 190         


Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu Asn Ser Lys Gln Leu 
        195                 200                 205             


Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Leu Glu Lys Lys Asp Arg 
    210                 215                 220                 


Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser Gly Ile Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Arg Lys Cys Phe 
                245                 250                 255     


Asn Leu Asp Glu Lys Ala Ser Leu His Phe Ser Lys Glu Ser Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Thr Leu Leu Gly Tyr Ile Gly Asp Asp Tyr Ser Asp 
        275                 280                 285             


Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Phe Leu Thr Val Thr Asp Asn Glu Thr Glu Ala Pro Leu Ser Ser Ala 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asn Glu His Lys Glu Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Glu Tyr Ile Arg Asn Ile Ser Leu Lys Thr Tyr Asn Glu Val Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Asp Phe Tyr Val Tyr Leu Lys Asn Leu Leu Ala Glu Phe Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Leu Asp Lys Gln Ala Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala Trp 
    450                 455                 460                 


Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro Trp Asn Phe Glu Asp 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu Leu Thr Lys Val Arg 
        515                 520                 525             


Phe Ile Ala Glu Ser Met Arg Asp Tyr Gln Phe Leu Asp Ser Lys Gln 
    530                 535                 540                 


Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp Lys Arg Lys Val Thr 
545                 550                 555                 560 


Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile Tyr Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ser Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys Glu Phe Leu Asp Asp 
        595                 600                 605             


Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ser Lys Phe Glu Asn 
625                 630                 635                 640 


Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Glu 
            660                 665                 670         


Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ile Ser 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ala Leu Ser Phe Lys 
    690                 695                 700                 


Lys Lys Ile Gln Lys Ala Gln Ile Ile Gly Asp Glu Asp Lys Gly Asn 
705                 710                 715                 720 


Ile Lys Glu Val Val Lys Ser Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly Gly Arg Lys Pro Glu Ser Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Tyr Thr Asn Gln Gly Lys Ser Asn Ser Gln Gln Arg Leu Lys Arg 
    770                 775                 780                 


Leu Glu Lys Ser Leu Lys Glu Leu Gly Ser Lys Ile Leu Lys Glu Asn 
785                 790                 795                 800 


Ile Pro Ala Lys Leu Ser Lys Ile Asp Asn Asn Ala Leu Gln Asn Asp 
                805                 810                 815     


Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly 
            820                 825                 830         


Asp Asp Leu Asp Ile Asp Arg Leu Ser Asn Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Gln Ala Phe Leu Lys Asp Asn Ser Ile Asp Asn Lys Val Leu 
    850                 855                 860                 


Val Ser Ser Ala Ser Asn Arg Gly Lys Ser Asp Asp Phe Pro Ser Leu 
865                 870                 875                 880 


Glu Val Val Lys Lys Arg Lys Thr Phe Trp Tyr Gln Leu Leu Lys Ser 
                885                 890                 895     


Lys Leu Ile Ser Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Leu Pro Glu Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Leu Leu Asp Glu 
    930                 935                 940                 


Lys Phe Asn Asn Lys Lys Asp Glu Asn Asn Arg Ala Val Arg Thr Val 
945                 950                 955                 960 


Lys Ile Ile Thr Leu Lys Ser Thr Leu Val Ser Gln Phe Arg Lys Asp 
                965                 970                 975     


Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn Asp Phe His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Ile  Ala Ser Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly Asp Tyr  Pro Lys Tyr 
    1010                 1015                 1020             


Asn Ser  Phe Arg Glu Arg Lys  Ser Ala Thr Glu Lys  Val Tyr Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Ile  Phe Lys Lys Ser Ile  Ser Leu Ala 
    1040                 1045                 1050             


Asp Gly  Arg Val Ile Glu Arg  Pro Leu Ile Glu Val  Asn Glu Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ser Val Trp Asn  Lys Glu Ser Asp Leu  Ala Thr Val 
    1070                 1075                 1080             


Arg Arg  Val Leu Ser Tyr Pro  Gln Val Asn Val Val  Lys Lys Val 
    1085                 1090                 1095             


Glu Glu  Gln Asn His Gly Leu  Asp Arg Gly Lys Pro  Lys Gly Leu 
    1100                 1105                 1110             


Phe Asn  Ala Asn Leu Ser Ser  Lys Pro Lys Pro Asn  Ser Asn Glu 
    1115                 1120                 1125             


Asn Leu  Val Gly Ala Lys Glu  Tyr Leu Asp Pro Lys  Lys Tyr Gly 
    1130                 1135                 1140             


Gly Tyr  Ala Gly Ile Ser Asn  Ser Phe Ala Val Leu  Val Lys Gly 
    1145                 1150                 1155             


Thr Ile  Glu Lys Gly Ala Lys  Lys Lys Ile Thr Asn  Val Leu Glu 
    1160                 1165                 1170             


Phe Gln  Gly Ile Ser Ile Leu  Asp Arg Ile Asn Tyr  Arg Lys Asp 
    1175                 1180                 1185             


Lys Leu  Asn Phe Leu Leu Glu  Lys Gly Tyr Lys Asp  Ile Glu Leu 
    1190                 1195                 1200             


Ile Ile  Glu Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Ser Asp Gly 
    1205                 1210                 1215             


Ser Arg  Arg Met Leu Ala Ser  Ile Leu Ser Thr Asn  Asn Lys Arg 
    1220                 1225                 1230             


Gly Glu  Ile His Lys Gly Asn  Gln Ile Phe Leu Ser  Gln Lys Phe 
    1235                 1240                 1245             


Val Lys  Leu Leu Tyr His Ala  Lys Arg Ile Ser Asn  Thr Ile Asn 
    1250                 1255                 1260             


Glu Asn  His Arg Lys Tyr Val  Glu Asn His Lys Lys  Glu Phe Glu 
    1265                 1270                 1275             


Glu Leu  Phe Tyr Tyr Ile Leu  Glu Phe Asn Glu Asn  Tyr Val Gly 
    1280                 1285                 1290             


Ala Lys  Lys Asn Gly Lys Leu  Leu Asn Ser Ala Phe  Gln Ser Trp 
    1295                 1300                 1305             


Gln Asn  His Ser Ile Asp Glu  Leu Cys Ser Ser Phe  Ile Gly Pro 
    1310                 1315                 1320             


Thr Gly  Ser Glu Arg Lys Gly  Leu Phe Glu Leu Thr  Ser Arg Gly 
    1325                 1330                 1335             


Ser Ala  Ala Asp Phe Glu Phe  Leu Gly Val Lys Ile  Pro Arg Tyr 
    1340                 1345                 1350             


Arg Asp  Tyr Thr Pro Ser Ser  Leu Leu Lys Asp Ala  Thr Leu Ile 
    1355                 1360                 1365             


His Gln  Ser Val Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ala 
    1370                 1375                 1380             


Lys Leu  Gly Glu Gly 
    1385             


<210>  632
<211>  1370
<212>  PRT
<213>  Streptococcus sanguinis SK353

<400>  632

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Phe Gly Asp Thr Asp Arg Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Thr Leu Leu Phe Asp Asp Gly Asn Thr Ala Glu Ser Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Thr Glu Ser Met Asn Glu Ile Asp Glu Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Asp Ser Phe Leu Val Pro Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Glu Tyr 
        115                 120                 125             


His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala Asp 
    130                 135                 140                 


Ser Lys Glu Lys Ser Asp Val Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Thr Phe Asp Ile 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Asn Ile Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln Val 
        195                 200                 205             


Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Glu Glu Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala Asp 
        275                 280                 285             


Leu Phe Leu Ile Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Glu Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Ala Leu Lys 
                325                 330                 335     


Gln Phe Ile Lys Asn Asn Leu Pro Glu Lys Tyr Val Glu Val Phe Ser 
            340                 345                 350         


Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Thr 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Asp Asn Arg Asp Phe Ser Trp 
    450                 455                 460                 


Leu Thr Arg Asn Ser Asp Glu Pro Ile Arg Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Ala Arg Ser Ala Glu Asp Phe Ile His Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly Gln 
    530                 535                 540                 


Lys Lys Gln Ile Val Asn Gln Leu Phe Lys Glu Lys Arg Lys Val Thr 
545                 550                 555                 560 


Glu Lys Asp Ile Ile His Tyr Leu His Asn Val Asp Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Asn Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Thr Lys Asp Lys Glu Phe Met Asp Asp 
        595                 600                 605             


Pro Lys Asn Glu Glu Ile Leu Glu Asn Ile Val His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asp Thr 
625                 630                 635                 640 


Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Asp Lys Ile 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe Lys 
    690                 695                 700                 


Glu Ile Ile Gln Lys Ala Gln Val Val Gly Lys Thr Asp Asp Val Lys 
705                 710                 715                 720 


Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 
            740                 745                 750         


Ala Leu Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu Asp 
    770                 775                 780                 


Ala Leu Lys Asn Leu Ala Pro Gly Leu Asp Ser Asn Ile Leu Lys Glu 
785                 790                 795                 800 


Asn Pro Thr Asp Asn Ile Gln Leu Lys Asn Asp Arg Leu Phe Leu Tyr 
                805                 810                 815     


Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Lys Pro Leu Asp Ile 
            820                 825                 830         


Asn Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe 
        835                 840                 845             


Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Asp 
    850                 855                 860                 


Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val Val Gln Lys 
865                 870                 875                 880 


Arg Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser Glu 
                885                 890                 895     


Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asp Glu 
            900                 905                 910         


Arg Asp Lys Val Gly Phe Ile Arg Arg Gln Leu Val Glu Thr Gln Gln 
        915                 920                 925             


Ile Thr Lys Asn Val Ala Gln Ile Leu Asp Ala Arg Phe Asn Thr Glu 
    930                 935                 940                 


Val Lys Glu Lys Asn Gln Lys Ile Arg Thr Val Lys Ile Ile Thr Leu 
945                 950                 955                 960 


Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly Leu Tyr Lys 
                965                 970                 975     


Val Arg Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn 
            980                 985                 990         


Ala Val Val Ala Lys Ala Ile Leu  Lys Lys Tyr Pro Lys  Leu Glu Pro 
        995                 1000                 1005             


Glu Phe  Val Tyr Gly Asp Tyr  Gln Lys Tyr Asp Leu  Lys Lys Tyr 
    1010                 1015                 1020             


Ile Ser  Arg Phe Lys Pro Ser  Lys Glu Ile Glu Lys  Ala Thr Glu 
    1025                 1030                 1035             


Lys Tyr  Phe Phe Tyr Ser Asn  Leu Leu Asn Phe Phe  Lys Glu Glu 
    1040                 1045                 1050             


Val Leu  Tyr Ala Asp Gly Thr  Ile Arg Lys Arg Glu  Asn Ile Glu 
    1055                 1060                 1065             


Tyr Ser  Lys Asp Thr Gly Glu  Ile Ala Trp Asp Lys  Glu Lys Asp 
    1070                 1075                 1080             


Phe Ala  Thr Ile Lys Lys Val  Leu Ser Tyr Pro Gln  Val Asn Ile 
    1085                 1090                 1095             


Val Lys  Lys Arg Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1100                 1105                 1110             


Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu Ile Pro  Arg Lys Thr 
    1115                 1120                 1125             


Lys Asp  Ile Leu Trp Asp Thr  Thr Lys Tyr Gly Gly  Phe Asp Ser 
    1130                 1135                 1140             


Pro Val  Ile Ala Tyr Ser Ile  Leu Leu Ile Ala Asp  Ile Glu Lys 
    1145                 1150                 1155             


Gly Lys  Ala Lys Lys Leu Lys  Thr Val Lys Thr Leu  Val Gly Ile 
    1160                 1165                 1170             


Thr Ile  Met Glu Lys Ala Ala  Phe Glu Glu Asn Pro  Ile Thr Phe 
    1175                 1180                 1185             


Leu Glu  Asn Lys Gly Tyr His  Asn Val Arg Lys Glu  Asn Ile Leu 
    1190                 1195                 1200             


Cys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Arg 
    1205                 1210                 1215             


Arg Leu  Leu Ala Ser Ala Lys  Glu Leu Gln Lys Gly  Asn Glu Ile 
    1220                 1225                 1230             


Val Leu  Pro Val Cys Leu Thr  Thr Leu Leu Tyr His  Ser Lys Asn 
    1235                 1240                 1245             


Leu His  Lys Leu Asp Glu Pro  Glu His Leu Glu Tyr  Ile Gln Lys 
    1250                 1255                 1260             


His Arg  Asn Glu Phe Lys Asp  Leu Leu Asn Leu Val  Ser Glu Phe 
    1265                 1270                 1275             


Ser Gln  Lys Tyr Ile Leu Ala  Glu Ala Asn Leu Glu  Lys Ile Lys 
    1280                 1285                 1290             


Asp Leu  Tyr Ala Asp Asn Glu  Gln Ala Asp Ile Glu  Ile Leu Ala 
    1295                 1300                 1305             


Asn Ser  Phe Ile Asn Leu Leu  Thr Phe Thr Ala Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Gly  Lys Asp Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Thr  Val Ser Glu Ile Leu  Asn Ala Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly 
    1355                 1360                 1365             


Glu Glu  
    1370 


<210>  633
<211>  1155
<212>  PRT
<213>  Streptococcus dysgalactiae subsp. equisimilis SK1250

<400>  633

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Ser Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Ser Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Met Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Glu Phe Leu Ser Gly Lys Gln 
    530                 535                 540                 


Lys Glu Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Ile Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Ala Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Arg Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asp Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Glu Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Ala Leu Thr  Asn Glu Ser Ile Tyr  Ala Arg Gly 
    1100                 1105                 1110             


Ser Phe  Asp Lys Leu Ile Ser  Arg Lys His Arg Phe  Glu Ser Ser 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Gly Ser  Pro Thr Val Thr Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Tyr Gln Ser  Tyr Lys Met Glu Lys  
    1145                 1150                 1155 


<210>  634
<211>  153
<212>  PRT
<213>  Streptococcus dysgalactiae subsp. equisimilis SK1250

<400>  634

Met Ala Asn Asn Asn Ser Arg Gly Asp Leu Gln Lys Ala Asn Glu Met 
1               5                   10                  15      


Phe Leu Pro Ala Lys Leu Val Thr Leu Leu Tyr His Ala His Lys Ile 
            20                  25                  30          


Glu Ser Ser Lys Glu Leu Glu His Glu Ala Tyr Ile Leu Asp His Tyr 
        35                  40                  45              


Asn Asp Leu Tyr Gln Leu Leu Ser Tyr Ile Glu Arg Phe Ala Ser Leu 
    50                  55                  60                  


Tyr Val Asp Val Glu Lys Asn Ile Ser Lys Val Lys Glu Leu Phe Ser 
65                  70                  75                  80  


Asn Ile Glu Ser Tyr Ser Ile Ser Glu Ile Cys Ser Ser Val Ile Asn 
                85                  90                  95      


Leu Leu Thr Leu Thr Ala Ser Gly Ala Pro Ala Asp Phe Lys Phe Leu 
            100                 105                 110         


Gly Thr Thr Ile Pro Arg Lys Arg Tyr Gly Ser Pro Gln Ser Ile Leu 
        115                 120                 125             


Ser Ser Thr Leu Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg 
    130                 135                 140                 


Ile Asp Leu Ser Gln Leu Gly Gly Asp 
145                 150             


<210>  635
<211>  1345
<212>  PRT
<213>  Streptococcus mutans B

<400>  635

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  636
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae SA20-06

<400>  636

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Ser Phe Glu Asn Asn His Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Val 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Gln Leu Leu Asp Phe Leu Ala Lys Glu Phe Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Ile Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Arg Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Ser Asp 
        675                 680                 685             


Gly Arg Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ser Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Glu Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asp Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile Asp Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Ala Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Ile Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Pro Asp Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Lys Val Asp Asp Asn Asn Lys Pro Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Glu 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Glu Thr Gly 
    1055                 1060                 1065             


Glu Ile  Ala Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Ser Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Leu Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Lys Glu Leu Ile  Gly Ile Thr Ile Met  Glu Arg Glu 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Thr Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Tyr 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Ser Asp Asn Lys Asp  Asn Thr Pro Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Lys Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ser Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asp Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  637
<211>  1392
<212>  PRT
<213>  Streptococcus mitis SK321

<400>  637

Met Asn Asn Asn Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys His Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Ala Thr Ala Glu Asp Arg Arg 
    50                  55                  60                  


Phe Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Ser Lys Val Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Val Pro Glu Asp Lys 
            100                 105                 110         


Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Ala Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ser Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Ser Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 
    210                 215                 220                 


Arg Ile Leu Lys Leu Phe Ala Tyr Glu Lys Ser Thr Asp Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Ala Leu 
                325                 330                 335     


Lys Gln Phe Ile Gln Asn Asn Leu Gln Glu Lys Tyr Asp Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Arg Tyr Ile Asn Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Glu Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Ile Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Tyr Lys Glu Lys Ile Glu Thr Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asn Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Gln Ala Ser Ser Ala Glu Glu Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ser Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly 
    530                 535                 540                 


Gln Lys Lys Gln Ile Val Asn Gln Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Gln Tyr Leu His Asn Val Asp Gly Tyr Asp 
                565                 570                 575     


Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Met Asp 
        595                 600                 605             


Asp Pro Lys Asn Glu Glu Ile Leu Glu Asn Ile Val His Thr Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Ala 
625                 630                 635                 640 


Ser Ile Phe Asp Lys Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Cys Asp 
            660                 665                 670         


Lys Lys Thr Gly Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Tyr 
        675                 680                 685             


Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe 
    690                 695                 700                 


Lys Asp Ile Ile Gln Lys Ala Gln Val Val Gly Lys Thr Asn Asp Val 
705                 710                 715                 720 


Lys Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Ile Lys Leu Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Ala Pro Glu Ser Ile Val Ile Glu Ile Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu 
    770                 775                 780                 


Asp Ala Leu Lys Asn Leu Ala Pro Gly Leu Asp Ser Asn Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Glu Ala Leu Asp 
            820                 825                 830         


Ile Asn Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Val Pro Gln Ala 
        835                 840                 845             


Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys 
    850                 855                 860                 


Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val Val Gln 
865                 870                 875                 880 


Lys Arg Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser 
                885                 890                 895     


Glu His Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asp 
            900                 905                 910         


Glu Arg Asp Lys Val Gly Phe Ile Arg Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala Arg Phe Asn Thr 
    930                 935                 940                 


Glu Val Asn Glu Lys Asp Lys Lys Asn Arg Thr Val Lys Ile Ile Thr 
945                 950                 955                 960 


Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Lys Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Ala Val Val Ala Lys Ala Ile  Leu Lys Lys Tyr Pro  Lys Leu Glu 
        995                 1000                 1005             


Pro Gly  Phe Val Tyr Gly Asp  Tyr Gln Lys Tyr Asp  Ile Lys Arg 
    1010                 1015                 1020             


Tyr Ile  Ser Arg Ser Lys Asp  Pro Lys Glu Val Glu  Lys Ala Thr 
    1025                 1030                 1035             


Glu Lys  Tyr Phe Phe Tyr Ser  Asn Leu Leu Asn Phe  Phe Lys Glu 
    1040                 1045                 1050             


Glu Val  His Tyr Ala Asp Gly  Thr Ile Val Lys Arg  Glu Asn Ile 
    1055                 1060                 1065             


Glu Tyr  Ser Lys Asp Thr Gly  Glu Ile Ala Trp Asn  Lys Glu Lys 
    1070                 1075                 1080             


Asp Phe  Ala Thr Ile Lys Lys  Val Leu Ser Leu Pro  Gln Val Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Thr Glu Ile  Gln Thr His Gly Leu  Asp Arg Gly 
    1100                 1105                 1110             


Lys Pro  Arg Gly Leu Phe Asn  Ser Asn Pro Ser Pro  Lys Pro Ser 
    1115                 1120                 1125             


Glu Asp  Arg Lys Glu Asn Leu  Val Pro Ile Lys Gln  Gly Leu Asp 
    1130                 1135                 1140             


Pro Arg  Lys Tyr Gly Gly Tyr  Ala Gly Ile Ser Asn  Ser Tyr Ala 
    1145                 1150                 1155             


Val Leu  Val Lys Ala Ile Ile  Glu Lys Gly Ala Lys  Lys Gln Gln 
    1160                 1165                 1170             


Lys Thr  Val Leu Glu Phe Gln  Gly Ile Ser Ile Leu  Asp Lys Ile 
    1175                 1180                 1185             


Asn Phe  Glu Lys Asn Lys Glu  Asn Tyr Leu Leu Glu  Lys Gly Tyr 
    1190                 1195                 1200             


Ile Lys  Ile Leu Ser Thr Ile  Thr Leu Pro Lys Tyr  Ser Leu Phe 
    1205                 1210                 1215             


Glu Phe  Pro Asp Gly Thr Arg  Arg Arg Leu Ala Ser  Ile Leu Ser 
    1220                 1225                 1230             


Thr Asn  Asn Lys Arg Gly Glu  Ile His Lys Gly Asn  Glu Leu Val 
    1235                 1240                 1245             


Ile Pro  Glu Lys Tyr Thr Thr  Leu Leu Tyr His Ala  Lys Asn Ile 
    1250                 1255                 1260             


Asn Lys  Thr Leu Glu Pro Glu  His Leu Glu Tyr Val  Glu Lys His 
    1265                 1270                 1275             


Arg Asn  Asp Phe Ala Lys Leu  Leu Glu Tyr Val Leu  Asn Phe Asn 
    1280                 1285                 1290             


Asp Lys  Tyr Val Gly Ala Leu  Lys Asn Gly Glu Arg  Ile Arg Gln 
    1295                 1300                 1305             


Ala Phe  Ile Asp Trp Glu Thr  Val Asp Ile Glu Lys  Leu Cys Phe 
    1310                 1315                 1320             


Ser Phe  Ile Gly Pro Arg Asn  Ser Lys Asn Ala Gly  Leu Phe Glu 
    1325                 1330                 1335             


Leu Thr  Ser Gln Gly Ser Ala  Ser Asp Phe Glu Phe  Leu Gly Val 
    1340                 1345                 1350             


Lys Ile  Pro Arg Tyr Arg Asp  Tyr Thr Pro Ser Ser  Leu Leu Asn 
    1355                 1360                 1365             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1370                 1375                 1380             


Ile Asp  Leu Ser Lys Leu Gly  Glu Asp 
    1385                 1390         


<210>  638
<211>  1377
<212>  PRT
<213>  Streptococcus sp. C300

<400>  638

Met Asn Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ser Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Arg Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Ala Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Ile Pro Glu Asp Lys 
            100                 105                 110         


Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Val Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Val Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ala Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln 
        195                 200                 205             


Val Glu Thr Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 
    210                 215                 220                 


Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Glu Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Val Ala Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Val Leu 
                325                 330                 335     


Lys Gln Phe Ile Lys Thr Asn Leu Pro Glu Lys Tyr Val Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Asp Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Val Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Thr Ile Leu Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr His Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Asp Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Met Arg Asp Tyr Gln Phe Leu Asp Ser Gly 
    530                 535                 540                 


Gln Lys Lys Lys Ile Ile Asn Gln Leu Phe Lys Lys Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Asp Asp Ile Ile Asp Cys Leu Gln Lys Ile Asp Asn Tyr Asp 
                565                 570                 575     


Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Ile Leu Lys Ile Ile Arg Asp Lys Glu Phe Met Asp 
        595                 600                 605             


Asp Pro Lys Asn Gly Asp Ile Leu Glu Asn Val Ile His Thr Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asn 
625                 630                 635                 640 


Ser Ile Phe Asp Glu Lys Val Ile Lys Ala Leu Ser Arg Lys His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asp Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Thr Gly Lys Thr Ile Leu Asp Tyr Leu Met Asp Asp Gly Lys 
        675                 680                 685             


Ser Asn Arg Asn Phe Met Gln Leu Ile Lys Asp Asp Glu Leu Ser Phe 
    690                 695                 700                 


Thr Glu Ile Ile Gln Lys Ala Gln Val Val Gly Asp Thr Asp Asn Leu 
705                 710                 715                 720 


Arg Gln Val Val Gln Asn Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Ala Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu 
    770                 775                 780                 


Asp Ser Leu Lys Asn Leu Ala Ser Gly Leu Asp Ser Asn Ile Leu Lys 
785                 790                 795                 800 


Glu Asn Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Glu Ala Leu Asn 
            820                 825                 830         


Ile Asn Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Ile Pro Gln Ala 
        835                 840                 845             


Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys 
    850                 855                 860                 


Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val Val Glu 
865                 870                 875                 880 


Lys Met Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser 
                885                 890                 895     


Glu Arg Lys Tyr Asn Asn Leu Thr Lys Ala Glu Arg Glu Arg Gly Gly 
            900                 905                 910         


Leu Asn Glu Leu Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala Arg Phe 
    930                 935                 940                 


Asn Lys Glu Val Thr Glu Lys Asn Lys Lys Asn Arg Asn Val Lys Ile 
945                 950                 955                 960 


Ile Thr Leu Lys Ser Asn Met Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Leu Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Lys Lys  Tyr Pro Lys 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Gln Lys  Tyr Asp Leu 
    1010                 1015                 1020             


Lys Arg  Tyr Ile Ser Arg Ser  Lys Asp Pro Lys Glu  Val Glu Lys 
    1025                 1030                 1035             


Ala Thr  Glu Lys Tyr Phe Phe  Tyr Ser Asn Leu Leu  Asn Phe Phe 
    1040                 1045                 1050             


Lys Glu  Glu Val His Tyr Ala  Asp Gly Thr Ile Val  Lys Arg Glu 
    1055                 1060                 1065             


Asn Ile  Glu Tyr Ser Lys Asp  Thr Gly Glu Ile Ala  Trp Asn Lys 
    1070                 1075                 1080             


Glu Lys  Asp Phe Ala Thr Ile  Lys Lys Val Leu Ser  Leu Pro Gln 
    1085                 1090                 1095             


Val Asn  Ile Val Lys Lys Thr  Glu Glu Gln Thr Val  Gly Gln Asn 
    1100                 1105                 1110             


Gly Gly  Leu Phe Asp Asn Asn  Ile Val Ser Lys Lys  Lys Val Val 
    1115                 1120                 1125             


Asp Ala  Ser Lys Leu Ile Pro  Ile Lys Ser Gly Leu  Ser Pro Glu 
    1130                 1135                 1140             


Lys Tyr  Gly Gly Tyr Ala Arg  Pro Thr Ile Ala Tyr  Ser Val Leu 
    1145                 1150                 1155             


Val Thr  Tyr Lys Gln Asn Asn  Lys Ile Lys Asn Thr  Met Val Gly 
    1160                 1165                 1170             


Ile Pro  Val Leu Thr Lys Leu  Glu Phe Glu Arg Asp  Pro Asn Leu 
    1175                 1180                 1185             


Tyr Leu  Arg Asn Leu Gly Ile  Asn Asn Val Ser His  Val Ile Lys 
    1190                 1195                 1200             


Leu Val  Lys Tyr Thr Val Leu  Glu Phe Lys His Lys  Tyr Gly Thr 
    1205                 1210                 1215             


Tyr Arg  Arg Phe Ile Val Ser  Asn Gln Glu Leu Lys  Arg Ala Asn 
    1220                 1225                 1230             


Gln Ile  Phe Val Thr Thr Lys  Gln Met Lys Leu Ile  Ser Gln Tyr 
    1235                 1240                 1245             


Thr Thr  Leu Asp Lys Asn Glu  His Asp Ser Leu Leu  Lys Asn Asn 
    1250                 1255                 1260             


Gln Gln  Leu Ile Gln Ser Ile  Trp Asn Gln Phe Leu  Glu Phe Met 
    1265                 1270                 1275             


Leu Ala  Thr Asp Leu Val Asn  Lys Lys Gln Tyr Asp  Glu Leu Ile 
    1280                 1285                 1290             


Leu Thr  Asn Asn Gln Thr Ile  Glu Glu Cys Arg Asn  Ile Met Asn 
    1295                 1300                 1305             


Arg Val  Ile Thr Thr Leu Ser  Phe Thr Asn Ile Asn  Ala Gly Gln 
    1310                 1315                 1320             


Lys Lys  Ile Ile Phe Asp Asp  Thr Leu Ser Leu Pro  Ile Lys Arg 
    1325                 1330                 1335             


Trp Gln  Phe Thr Asp Ser Asp  Lys Met Val Lys Lys  Ile Ile Glu 
    1340                 1345                 1350             


Ser Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1355                 1360                 1365             


Ile Asp  Leu Ser Lys Leu Gly  Glu Asp 
    1370                 1375         


<210>  639
<211>  1345
<212>  PRT
<213>  Streptococcus mutans 14D

<400>  639

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  640
<211>  1345
<212>  PRT
<213>  Streptococcus mutans 5DC8

<400>  640

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Leu Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Gly Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys His Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Phe  Lys Glu Ser Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  641
<211>  1345
<212>  PRT
<213>  Streptococcus mutans SF1

<400>  641

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  642
<211>  1350
<212>  PRT
<213>  Streptococcus mutans 24

<400>  642

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Thr Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Gln Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val Val Asn Arg Met Arg 
865                 870                 875                 880 


Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu Ile Ser Gln Arg Lys 
                885                 890                 895     


Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Leu Asp Asp Lys Ala Gly 
            900                 905                 910         


Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val 
        915                 920                 925             


Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu Phe Asp Asp Asn Asn 
    930                 935                 940                 


Lys Arg Ile Cys Lys Val Lys Ile Val Thr Leu Lys Ser Asn Leu Val 
945                 950                 955                 960 


Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn 
                965                 970                 975     


Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Val Lys 
            980                 985                 990         


Ala Leu Leu Val Lys Tyr Ser Lys  Leu Glu Pro Glu Phe  Val Tyr Gly 
        995                 1000                 1005             


Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu Arg Lys  Thr Ala Thr 
    1010                 1015                 1020             


Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met Asn Met  Phe Lys Ser 
    1025                 1030                 1035             


Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val Glu Arg  Pro Met Ile 
    1040                 1045                 1050             


Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala Trp Asp  Lys Thr Lys 
    1055                 1060                 1065             


His Ile  Thr Thr Val Lys Lys  Val Leu Ser Tyr Pro  Gln Val Asn 
    1070                 1075                 1080             


Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile Gly Gln  Asn Gly Gly 
    1085                 1090                 1095             


Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu Glu Val  Ile Pro Ser 
    1100                 1105                 1110             


Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn Pro Glu  Lys Tyr Gly 
    1115                 1120                 1125             


Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro Ile Leu  Leu Ile Val 
    1130                 1135                 1140             


Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val Met Asp  Lys Lys Arg 
    1145                 1150                 1155             


Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys Asp Lys  Gly Tyr Gln 
    1160                 1165                 1170             


Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu Pro Lys  Tyr Thr Leu 
    1175                 1180                 1185             


Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu Trp Ala  Ser Ser Lys 
    1190                 1195                 1200             


Glu Val  His Lys Gly Asn Gln  Leu Val Val Ser Lys  Lys Ser Gln 
    1205                 1210                 1215             


Asp Leu  Leu Tyr His Ala His  His Leu Asp Asn Asp  Tyr Ser Asn 
    1220                 1225                 1230             


Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe Asp Ile  Leu Phe Asn 
    1235                 1240                 1245             


Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys Leu Gly  Lys Glu His 
    1250                 1255                 1260             


Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys Glu Arg  Asp Ser Ala 
    1265                 1270                 1275             


Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile Lys Leu  Leu Gly Phe 
    1280                 1285                 1290             


Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser Phe Leu  Gly Ile Lys 
    1295                 1300                 1305             


Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys Asp Tyr  Leu Leu Pro 
    1310                 1315                 1320             


Cys Met  Glu Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1325                 1330                 1335             


Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345                 1350 


<210>  643
<211>  1386
<212>  PRT
<213>  Streptococcus anginosus SK1138

<400>  643

Met Asn Gln Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Gln Ser Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Met Gln Val Asp Glu Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Asp Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Ile Ala Ala Glu Val Lys Tyr 
        115                 120                 125             


His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ile Ser Gln Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gln Leu Lys Ala 
                165                 170                 175     


Glu Asn Thr Asn Val Gln Ala Leu Phe Lys Asp Phe Val Glu Val Tyr 
            180                 185                 190         


Asp Lys Thr Val Glu Glu Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala His Tyr Pro Ala Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Phe Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Gly Leu Leu Gly Glu Val Gly Asp Glu Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Glu Glu His Gln Lys Asp Leu Lys Lys Phe Glu 
                325                 330                 335     


Asp Phe Ile Lys Val Asn Ala Leu Asp Gln Tyr Asn Ala Ile Phe Lys 
            340                 345                 350         


Asp Lys Asn Lys Lys Gly Tyr Ala Gly Tyr Ile Glu Ser Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Gly Ile Leu Leu Gln Ile Asn 
    370                 375                 380                 


Gly Ser Gly Asp Phe Leu Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Gly Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr Lys Ala Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp 
465                 470                 475                 480 


Ile Leu Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr 
                485                 490                 495     


Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Asn Glu Gln Gly Glu Ala Lys Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile 
                565                 570                 575     


Val Asn Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ser Ser 
            580                 585                 590         


Leu Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asn Lys Ser Phe Leu 
        595                 600                 605             


Asp Asn Lys Glu Asn Ala Gln Ile Ile Glu Asp Ile Ile Gln Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr 
625                 630                 635                 640 


Ser Asp Ile Phe Thr Lys Ala Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Asn Lys Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Tyr Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Ile Ile Gly Asp Val Asp Asp 
705                 710                 715                 720 


Ile Ala Asn Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly His Asn Pro Ala Asn Ile Ile Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Asp Arg Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Leu Leu 
    770                 775                 780                 


Gln Asp Ser Leu Lys Asn Leu Asp Asn Pro Val Asn Ile Lys Asn Val 
785                 790                 795                 800 


Glu Asn Gln Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Ile Gln 
                805                 810                 815     


Asn Gly Lys Asp Met Tyr Thr Gly Glu Thr Leu Asp Ile Asn Asn Leu 
            820                 825                 830         


Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Tyr Ile Lys Asp 
        835                 840                 845             


Asp Ser Phe Asp Asn Arg Val Leu Thr Ser Ser Ser Glu Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Ile Glu Val Val Cys Ala Arg Lys Ala 
865                 870                 875                 880 


Asp Trp Met Arg Leu Arg Lys Ala Gly Leu Ile Ser Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Glu Asn Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Val Leu Asp Ala Arg Phe Asn Ala Lys His Asp Glu 
    930                 935                 940                 


Asn Lys Lys Val Ile Arg Asp Val Lys Ile Ile Thr Leu Lys Ser Asn 
945                 950                 955                 960 


Leu Val Ser Gln Phe Arg Lys Asp Phe Lys Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Ile 
            980                 985                 990         


Gly Thr Ala Leu Leu Lys Lys Tyr  Pro Lys Leu Ala Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Glu Phe Lys Lys Tyr  Asp Val Arg Lys Phe  Ile Ala Lys 
    1010                 1015                 1020             


Ser Asp  Lys Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Leu Met Asn Phe Phe  Lys Lys Glu Val Lys  Phe Ala Asp 
    1040                 1045                 1050             


Gly Thr  Val Val Glu Arg Pro  Asp Ile Glu Thr Ser  Glu Asp Gly 
    1055                 1060                 1065             


Glu Ile  Ala Trp Asn Lys Gln  Thr Asp Phe Lys Ile  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1085                 1090                 1095             


Gln Thr  His Gly Leu Asp Arg  Gly Lys Pro Arg Gly  Leu Phe Asn 
    1100                 1105                 1110             


Ala Asn  Pro Ser Pro Lys Pro  Lys Pro Asp Ser Ser  Glu Asn Leu 
    1115                 1120                 1125             


Val Gly  Val Lys Arg Asn Leu  Asp Pro Lys Lys Tyr  Gly Gly Tyr 
    1130                 1135                 1140             


Ala Gly  Ile Ser Asn Ser Tyr  Ala Val Leu Val Lys  Ala Ile Ile 
    1145                 1150                 1155             


Glu Lys  Gly Val Lys Lys Lys  Glu Thr Met Val Leu  Glu Phe Gln 
    1160                 1165                 1170             


Gly Ile  Ser Ile Leu Asp Arg  Ile Thr Phe Glu Lys  Asp Lys Arg 
    1175                 1180                 1185             


Ala Phe  Leu Leu Gly Lys Gly  Tyr Lys Asp Ile Lys  Lys Ile Ile 
    1190                 1195                 1200             


Glu Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Lys Asp  Gly Ser Arg 
    1205                 1210                 1215             


Arg Met  Leu Ala Ser Ile Leu  Ser Thr Asn Asn Lys  Arg Gly Glu 
    1220                 1225                 1230             


Ile His  Lys Gly Asn Glu Leu  Phe Val Pro Gln Lys  Phe Thr Thr 
    1235                 1240                 1245             


Leu Leu  Tyr His Ala Lys Arg  Ile Asn Asn Pro Ile  Asn Lys Asp 
    1250                 1255                 1260             


His Ile  Glu Tyr Val Lys Lys  His Arg Asp Asp Phe  Lys Glu Leu 
    1265                 1270                 1275             


Leu Asn  Tyr Val Leu Glu Phe  Asn Glu Lys Tyr Val  Gly Ala Thr 
    1280                 1285                 1290             


Lys Asn  Gly Glu Arg Leu Lys  Glu Ala Val Ala Asp  Phe Asp Ser 
    1295                 1300                 1305             


Lys Ser  Asn Glu Glu Ile Cys  Thr Ser Phe Leu Gly  Ala Val Asn 
    1310                 1315                 1320             


Ser Lys  Asn Ala Gly Leu Phe  Glu Leu Thr Ser Leu  Gly Ser Ala 
    1325                 1330                 1335             


Ser Asp  Phe Glu Phe Leu Gly  Val Lys Ile Pro Arg  Tyr Arg Asp 
    1340                 1345                 1350             


Tyr Thr  Pro Ser Ser Leu Leu  Lys Asp Ser Thr Leu  Ile His Gln 
    1355                 1360                 1365             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu 
    1370                 1375                 1380             


Gly Glu  Asp 
    1385     


<210>  644
<211>  1345
<212>  PRT
<213>  Streptococcus mutans SM6

<400>  644

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Gly Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  645
<211>  1375
<212>  PRT
<213>  Streptococcus canis FSL Z3-227

<400>  645

Met Glu Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asn Arg Lys Ser Ile Lys Lys Asn Leu Met 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Asn Glu Met Ala Lys Leu Asp Asp Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


Asn Glu Arg His Pro Ile Phe Gly Asn Leu Ala Asp Glu Val Ala Tyr 
        115                 120                 125             


His Arg Asn Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Pro Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Leu Asn Ala 
                165                 170                 175     


Glu Asn Ser Asp Val Ala Lys Leu Phe Tyr Gln Leu Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Ser Pro Leu Asp Glu Ile Glu Val Asp Ala 
        195                 200                 205             


Lys Gly Ile Leu Ser Ala Arg Leu Ser Lys Ser Lys Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Ala Val Phe Pro Asn Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Ile Ile Ala Leu Ala Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Thr Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Glu Leu Leu Gly Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ser Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Ser Asn Ser Glu Val Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Asp Glu His His Gln Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Thr Leu Val Arg Gln Gln Phe Pro Glu Lys Tyr Ala Glu Ile Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Val Gly Ile Gly Ile Lys 
        355                 360                 365             


His Arg Lys Arg Thr Thr Lys Leu Ala Thr Gln Glu Glu Phe Tyr Lys 
    370                 375                 380                 


Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Ala Glu Glu Leu Leu 
385                 390                 395                 400 


Ala Lys Leu Asn Arg Asp Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp 
                405                 410                 415     


Asn Gly Ser Ile Pro His Gln Ile His Leu Lys Glu Leu His Ala Ile 
            420                 425                 430         


Leu Arg Arg Gln Glu Glu Phe Tyr Pro Phe Leu Lys Glu Asn Arg Glu 
        435                 440                 445             


Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro 
    450                 455                 460                 


Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Leu Thr Arg Lys Ser Glu 
465                 470                 475                 480 


Glu Ala Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala 
                485                 490                 495     


Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Glu Gln Leu 
            500                 505                 510         


Pro Asn Lys Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe 
        515                 520                 525             


Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Arg Met 
    530                 535                 540                 


Arg Lys Pro Glu Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp 
545                 550                 555                 560 


Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu 
                565                 570                 575     


Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ile Gly 
            580                 585                 590         


Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu 
        595                 600                 605             


Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp 
    610                 615                 620                 


Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu 
625                 630                 635                 640 


Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys 
                645                 650                 655     


Val Met Lys Gln Leu Lys Arg Arg His Tyr Thr Gly Trp Gly Arg Leu 
            660                 665                 670         


Ser Arg Lys Met Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr 
        675                 680                 685             


Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ser Asn Arg Asn Phe Met 
    690                 695                 700                 


Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Glu Ile Glu Lys 
705                 710                 715                 720 


Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu Gln Ile Ala Asp 
                725                 730                 735     


Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys 
            740                 745                 750         


Ile Val Asp Glu Leu Val Lys Val Met Gly His Lys Pro Glu Asn Ile 
        755                 760                 765             


Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Thr Lys Gly Leu Gln 
    770                 775                 780                 


Gln Ser Arg Glu Arg Lys Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu 
785                 790                 795                 800 


Glu Ser Gln Ile Leu Lys Glu Asn Pro Val Glu Asn Thr Gln Leu Gln 
                805                 810                 815     


Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr 
            820                 825                 830         


Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp 
        835                 840                 845             


His Ile Val Pro Gln Ser Phe Ile Lys Asp Asp Ser Ile Asp Asn Lys 
    850                 855                 860                 


Val Leu Thr Arg Ser Val Glu Asn Arg Gly Lys Ser Asp Asn Val Pro 
865                 870                 875                 880 


Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu 
                885                 890                 895     


Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala 
            900                 905                 910         


Glu Arg Gly Gly Leu Ser Glu Ala Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu 
    930                 935                 940                 


Asp Ser Arg Met Asn Thr Lys Arg Asp Lys Asn Asp Lys Pro Ile Arg 
945                 950                 955                 960 


Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg 
                965                 970                 975     


Lys Asp Phe Gln Leu Tyr Lys Val Arg Asp Ile Asn Asn Tyr His His 
            980                 985                 990         


Ala His Asp Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
        995                 1000                 1005             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1010                 1015                 1020             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1025                 1030                 1035             


Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1040                 1045                 1050             


Phe Phe  Lys Thr Glu Val Lys  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1055                 1060                 1065             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Val Val Trp 
    1070                 1075                 1080             


Asn Lys  Glu Lys Asp Phe Ala  Thr Val Arg Lys Val  Leu Ala Met 
    1085                 1090                 1095             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1100                 1105                 1110             


Phe Ser  Lys Glu Ser Ile Leu  Ser Lys Arg Glu Ser  Ala Lys Leu 
    1115                 1120                 1125             


Ile Pro  Arg Lys Lys Gly Trp  Asp Thr Arg Lys Tyr  Gly Gly Phe 
    1130                 1135                 1140             


Gly Ser  Pro Thr Val Ala Tyr  Ser Ile Leu Val Val  Ala Lys Val 
    1145                 1150                 1155             


Glu Lys  Gly Lys Ala Lys Lys  Leu Lys Ser Val Lys  Val Leu Val 
    1160                 1165                 1170             


Gly Ile  Thr Ile Met Glu Lys  Gly Ser Tyr Glu Lys  Asp Pro Ile 
    1175                 1180                 1185             


Gly Phe  Leu Glu Ala Lys Gly  Tyr Lys Asp Ile Lys  Lys Glu Leu 
    1190                 1195                 1200             


Ile Phe  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1205                 1210                 1215             


Arg Arg  Arg Met Leu Ala Ser  Ala Thr Glu Leu Gln  Lys Ala Asn 
    1220                 1225                 1230             


Glu Leu  Val Leu Pro Gln His  Leu Val Arg Leu Leu  Tyr Tyr Thr 
    1235                 1240                 1245             


Gln Asn  Ile Ser Ala Thr Thr  Gly Ser Asn Asn Leu  Gly Tyr Ile 
    1250                 1255                 1260             


Glu Gln  His Arg Glu Glu Phe  Lys Glu Ile Phe Glu  Lys Ile Ile 
    1265                 1270                 1275             


Asp Phe  Ser Glu Lys Tyr Ile  Leu Lys Asn Lys Val  Asn Ser Asn 
    1280                 1285                 1290             


Leu Lys  Ser Ser Phe Asp Glu  Gln Phe Ala Val Ser  Asp Ser Ile 
    1295                 1300                 1305             


Leu Leu  Ser Asn Ser Phe Val  Ser Leu Leu Lys Tyr  Thr Ser Phe 
    1310                 1315                 1320             


Gly Ala  Ser Gly Gly Phe Thr  Phe Leu Asp Leu Asp  Val Lys Gln 
    1325                 1330                 1335             


Gly Arg  Leu Arg Tyr Gln Thr  Val Thr Glu Val Leu  Asp Ala Thr 
    1340                 1345                 1350             


Leu Ile  Tyr Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Thr Asp 
    1355                 1360                 1365             


Leu Ser  Gln Leu Gly Gly Asp  
    1370                 1375 


<210>  646
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes HKU QMH11M0907901

<400>  646

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Ile Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Leu Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Leu Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Thr Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Phe Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  647
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae GB00112

<400>  647

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Tyr Ser Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ser Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Asp Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Arg Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gln Asn Ile Asp 
        195                 200                 205             


Val Glu Gly Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Val Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Thr Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Gly Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Leu Val Asp Lys Glu Ala Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Ser Asp 
        675                 680                 685             


Gly Arg Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Pro Ile Ile Asp Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Val Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Thr Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Glu Glu Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Asp Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Ala Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Phe 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Asp Asp Lys  Leu Met Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Tyr 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Leu Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Gln  Lys Gln Glu Phe Val  Val Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  648
<211>  1378
<212>  PRT
<213>  Streptococcus agalactiae ATCC 13813

<400>  648

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Tyr Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Arg Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His His Glu Asp Leu Lys His Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Asn Tyr Arg Glu Val Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Ser Gln Glu Ala Phe Tyr Lys Tyr Leu Leu Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Leu Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Arg Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Phe Leu Ala Glu Gly Phe Lys Asp Phe Gln Phe Leu Asn Arg Lys 
    530                 535                 540                 


Gln Lys Glu Thr Ile Phe Asn Ser Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Ser Phe Leu Asn Lys Val Asp Gly Tyr Glu 
                565                 570                 575     


Gly Ile Ala Ile Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Lys Lys Ile Leu Gly Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Thr Asp Asn Glu Leu Ile Leu Glu Asp Ile Ile Gln Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Asp Ile Tyr Lys Asp 
625                 630                 635                 640 


Phe Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asn Lys 
            660                 665                 670         


Glu Asn Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ser Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Lys Asp Ala Gly Leu Ser Phe Lys 
    690                 695                 700                 


Pro Ile Ile Asp Lys Ala Arg Thr Gly Ser His Ser Asp Asn Leu Lys 
705                 710                 715                 720 


Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 
            740                 745                 750         


Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Leu Ser Arg Ser Arg Gln Arg Leu Thr Thr Leu Arg Glu 
    770                 775                 780                 


Ser Leu Gly Asn Leu Lys Ser Asn Ile Leu Glu Glu Lys Lys Pro Lys 
785                 790                 795                 800 


Tyr Val Lys Asp Gln Val Glu Asn His His Leu Ser Asp Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Asp Asp Glu 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile Glu Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Met Phe Trp Lys Asn Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Leu Tyr Arg Arg  Lys Lys Leu 
    1010                 1015                 1020             


Ser Lys  Ile Val Arg Glu Asp  Lys Glu Glu Lys Tyr  Ser Glu Ala 
    1025                 1030                 1035             


Thr Arg  Lys Met Phe Phe Tyr  Ser Asn Leu Met Asn  Met Phe Lys 
    1040                 1045                 1050             


Arg Val  Val Arg Leu Ala Asp  Gly Ser Ile Val Val  Arg Pro Val 
    1055                 1060                 1065             


Ile Glu  Thr Gly Arg Tyr Met  Gly Lys Thr Ala Trp  Asp Lys Lys 
    1070                 1075                 1080             


Lys His  Phe Ala Thr Val Arg  Lys Val Leu Ser Tyr  Pro Gln Asn 
    1085                 1090                 1095             


Asn Ile  Val Lys Lys Thr Glu  Ile Gln Thr Gly Gly  Phe Ser Lys 
    1100                 1105                 1110             


Glu Ser  Ile Leu Ala His Gly  Asn Ser Asp Lys Leu  Ile Pro Arg 
    1115                 1120                 1125             


Lys Thr  Lys Asp Ile Tyr Leu  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1130                 1135                 1140             


Asp Ser  Pro Ile Val Ala Tyr  Ser Val Leu Val Val  Ala Asp Ile 
    1145                 1150                 1155             


Lys Lys  Gly Lys Ala Gln Lys  Leu Lys Thr Val Thr  Glu Leu Leu 
    1160                 1165                 1170             


Gly Ile  Thr Ile Met Glu Arg  Ser Arg Phe Glu Lys  Asn Thr Ser 
    1175                 1180                 1185             


Ala Phe  Leu Glu Ser Lys Gly  Tyr Leu Asn Ile Arg  Asp Asp Lys 
    1190                 1195                 1200             


Leu Met  Ile Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1205                 1210                 1215             


Arg Arg  Arg Leu Leu Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn 
    1220                 1225                 1230             


Glu Leu  Ala Leu Pro Thr Gln  Phe Met Lys Phe Leu  Tyr Leu Ala 
    1235                 1240                 1245             


Ser Arg  Tyr Asn Glu Ser Lys  Gly Lys Pro Glu Glu  Ile Glu Lys 
    1250                 1255                 1260             


Lys Gln  Glu Phe Val Asn Gln  His Val Ser Tyr Phe  Asp Asp Ile 
    1265                 1270                 1275             


Leu Gln  Leu Ile Asn Asp Phe  Ser Asn Arg Val Ile  Leu Ala Asp 
    1280                 1285                 1290             


Ala Asn  Leu Glu Lys Ile Asn  Lys Leu Tyr Gln Asp  Asn Lys Glu 
    1295                 1300                 1305             


Asn Ile  Pro Val Asp Glu Leu  Ala Asn Asn Ile Ile  Asn Leu Phe 
    1310                 1315                 1320             


Thr Phe  Thr Ser Leu Gly Ala  Pro Ala Ala Phe Lys  Phe Phe Asp 
    1325                 1330                 1335             


Lys Ile  Val Asp Arg Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu 
    1340                 1345                 1350             


Asn Ser  Thr Leu Ile His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr 
    1355                 1360                 1365             


Arg Ile  Asp Leu Gly Lys Leu  Gly Glu Gly 
    1370                 1375             


<210>  649
<211>  1338
<212>  PRT
<213>  Streptococcus mutans NLML4

<400>  649

Met Asp Leu Ile Gly Thr Asn Ser Val Gly Trp Ala Val Val Thr Asp 
1               5                   10                  15      


Asp Tyr Lys Val Pro Ala Lys Lys Met Lys Val Leu Gly Asn Thr Asp 
            20                  25                  30          


Lys Ser His Ile Lys Lys Asn Leu Leu Gly Ala Leu Leu Phe Asp Ser 
        35                  40                  45              


Gly Asn Thr Ala Ala Asp Arg Arg Leu Lys Arg Thr Ala Arg Arg Arg 
    50                  55                  60                  


Tyr Thr Arg Arg Arg Asn Arg Ile Leu Tyr Leu Gln Glu Ile Phe Ala 
65                  70                  75                  80  


Glu Glu Met Ser Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Asp 
                85                  90                  95      


Ser Phe Leu Val Thr Glu Asp Lys Arg Gly Glu Arg His Pro Ile Phe 
            100                 105                 110         


Gly Asn Leu Glu Glu Glu Val Lys Tyr His Glu Asn Phe Pro Thr Ile 
        115                 120                 125             


Tyr His Leu Arg Gln Tyr Leu Ala Asp Asn Pro Glu Lys Val Asp Leu 
    130                 135                 140                 


Arg Leu Val Tyr Leu Ala Leu Ala His Ile Ile Lys Phe Arg Gly His 
145                 150                 155                 160 


Phe Leu Ile Glu Gly Lys Phe Asp Thr Arg Asn Asn Asp Val Gln Arg 
                165                 170                 175     


Leu Phe Gln Glu Phe Leu Ala Val Tyr Asp Asn Thr Phe Glu Asn Ser 
            180                 185                 190         


Ser Leu Gln Glu Gln Asn Val Gln Val Glu Glu Ile Leu Thr Asp Lys 
        195                 200                 205             


Ile Ser Lys Ser Ala Lys Lys Asp Arg Val Leu Lys Leu Phe Pro Asn 
    210                 215                 220                 


Glu Lys Ser Asn Gly Arg Phe Ala Glu Phe Leu Lys Leu Ile Val Gly 
225                 230                 235                 240 


Asn Gln Ala Asp Phe Lys Lys His Phe Glu Leu Glu Glu Lys Ala Pro 
                245                 250                 255     


Leu Gln Phe Ser Lys Asp Thr Tyr Glu Glu Glu Leu Glu Val Leu Leu 
            260                 265                 270         


Ala Gln Ile Gly Asp Asn Tyr Ala Glu Leu Phe Leu Ser Ala Lys Lys 
        275                 280                 285             


Leu Tyr Asp Ser Ile Leu Leu Ser Gly Ile Leu Thr Val Thr Asp Val 
    290                 295                 300                 


Ser Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Gln Arg Tyr Asn Glu 
305                 310                 315                 320 


His Gln Met Asp Leu Ala Gln Leu Lys Gln Phe Ile Arg Gln Lys Leu 
                325                 330                 335     


Ser Asp Lys Tyr Asn Glu Val Phe Ser Asp Val Ser Lys Asp Gly Tyr 
            340                 345                 350         


Ala Gly Tyr Ile Asp Gly Lys Thr Asn Gln Glu Ala Phe Tyr Lys Tyr 
        355                 360                 365             


Leu Lys Gly Leu Leu Asn Lys Ile Glu Gly Ser Gly Tyr Phe Leu Asp 
    370                 375                 380                 


Lys Ile Glu Arg Glu Asp Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn 
385                 390                 395                 400 


Gly Ser Ile Pro His Gln Ile His Leu Gln Glu Met Arg Ala Ile Ile 
                405                 410                 415     


Arg Arg Gln Ala Glu Phe Tyr Pro Phe Leu Ala Asp Asn Gln Asp Arg 
            420                 425                 430         


Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 
        435                 440                 445             


Ala Arg Gly Lys Ser Asp Phe Ala Trp Leu Ser Arg Lys Ser Ala Asp 
    450                 455                 460                 


Lys Ile Thr Pro Trp Asn Phe Asp Glu Ile Val Asp Lys Glu Ser Ser 
465                 470                 475                 480 


Ala Glu Ala Phe Ile Asn Arg Met Thr Asn Tyr Asp Leu Tyr Leu Pro 
                485                 490                 495     


Asn Gln Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Thr 
            500                 505                 510         


Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Lys Thr Glu Gln Gly Lys 
        515                 520                 525             


Thr Ala Phe Phe Asp Ala Asn Met Lys Gln Glu Ile Phe Asp Gly Val 
    530                 535                 540                 


Phe Lys Val Tyr Arg Lys Val Thr Lys Asp Lys Leu Met Asp Phe Leu 
545                 550                 555                 560 


Glu Lys Glu Phe Asp Glu Phe Arg Ile Val Asp Leu Thr Gly Leu Asp 
                565                 570                 575     


Lys Glu Asn Lys Ala Phe Asn Ala Ser Tyr Gly Thr Tyr His Asp Leu 
            580                 585                 590         


Arg Lys Ile Leu Asp Lys Asp Phe Leu Asp Asn Ser Lys Asn Glu Lys 
        595                 600                 605             


Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu 
    610                 615                 620                 


Met Ile Arg Lys Arg Leu Glu Asn Tyr Ser Asp Leu Leu Thr Lys Glu 
625                 630                 635                 640 


Gln Val Lys Lys Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg Leu 
                645                 650                 655     


Ser Ala Glu Leu Ile His Gly Ile Arg Asn Lys Glu Ser Arg Lys Thr 
            660                 665                 670         


Ile Leu Asp Tyr Leu Ile Asp Asp Gly Asn Ser Asn Arg Asn Phe Met 
        675                 680                 685             


Gln Leu Ile Asn Asp Asp Ala Leu Ser Phe Lys Glu Glu Ile Ala Lys 
    690                 695                 700                 


Ala Gln Val Ile Gly Glu Thr Asp Asn Leu Asn Gln Val Val Ser Asp 
705                 710                 715                 720 


Ile Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys 
                725                 730                 735     


Ile Val Asp Glu Leu Val Lys Ile Met Gly His Gln Pro Glu Asn Ile 
            740                 745                 750         


Val Val Glu Met Ala Arg Glu Asn Gln Phe Thr Asn Gln Gly Arg Arg 
        755                 760                 765             


Asn Ser Gln Gln Arg Leu Lys Gly Leu Thr Asp Ser Ile Lys Glu Phe 
    770                 775                 780                 


Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu His Ser Gln Leu Gln 
785                 790                 795                 800 


Asn Asp Arg Leu Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr 
                805                 810                 815     


Thr Gly Glu Glu Leu Asp Ile Asp Tyr Leu Ser Gln Tyr Asp Ile Asp 
            820                 825                 830         


His Ile Ile Pro Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg 
        835                 840                 845             


Val Leu Thr Ser Ser Lys Glu Asn Arg Gly Lys Ser Asp Asp Val Pro 
    850                 855                 860                 


Ser Lys Asn Val Val Arg Lys Met Lys Ser Tyr Trp Ser Lys Leu Leu 
865                 870                 875                 880 


Ser Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala 
                885                 890                 895     


Glu Arg Gly Gly Leu Thr Asp Asp Asp Lys Ala Gly Phe Ile Lys Arg 
            900                 905                 910         


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu 
        915                 920                 925             


Asp Glu Arg Phe His Thr Glu Thr Asp Glu Asn Asn Lys Lys Ile Arg 
    930                 935                 940                 


Gln Val Lys Ile Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg 
945                 950                 955                 960 


Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His 
                965                 970                 975     


Ala His Asp Ala Tyr Leu Asn Ala Val Ile Gly Lys Ala Leu Leu Gly 
            980                 985                 990         


Val Tyr Pro Gln Leu Glu Pro Glu  Phe Val Tyr Gly Asp  Tyr Pro His 
        995                 1000                 1005             


Phe His  Gly His Lys Glu Asn  Lys Ala Thr Ala Lys  Lys Phe Phe 
    1010                 1015                 1020             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Lys Asp Asp  Val Arg Thr 
    1025                 1030                 1035             


Asp Lys  Asn Gly Glu Ile Ile  Trp Lys Lys Asp Glu  His Ile Ser 
    1040                 1045                 1050             


Asn Ile  Lys Lys Val Leu Ser  Tyr Pro Gln Val Asn  Ile Val Lys 
    1055                 1060                 1065             


Lys Val  Glu Glu Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1070                 1075                 1080             


Pro Lys  Gly Asn Ser Asp Lys  Leu Ile Pro Arg Lys  Thr Lys Lys 
    1085                 1090                 1095             


Phe Tyr  Trp Asp Thr Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Ile 
    1100                 1105                 1110             


Val Ala  Tyr Ser Ile Leu Val  Ile Ala Asp Ile Glu  Lys Gly Lys 
    1115                 1120                 1125             


Ser Lys  Lys Leu Lys Thr Val  Lys Ala Leu Val Gly  Val Thr Ile 
    1130                 1135                 1140             


Met Glu  Lys Met Thr Phe Glu  Arg Asp Pro Val Ala  Phe Leu Glu 
    1145                 1150                 1155             


Arg Lys  Gly Tyr Arg Asn Val  Gln Glu Glu Asn Ile  Ile Lys Leu 
    1160                 1165                 1170             


Pro Lys  Tyr Ser Leu Phe Lys  Leu Glu Asn Gly Arg  Lys Arg Leu 
    1175                 1180                 1185             


Leu Ala  Ser Ala Arg Glu Leu  Gln Lys Gly Asn Glu  Ile Val Leu 
    1190                 1195                 1200             


Pro Asn  His Leu Gly Thr Leu  Leu Tyr His Ala Lys  Asn Ile His 
    1205                 1210                 1215             


Lys Val  Asp Glu Pro Lys His  Leu Asp Tyr Val Asp  Lys His Lys 
    1220                 1225                 1230             


Asp Glu  Phe Lys Glu Leu Leu  Asp Val Val Ser Asn  Phe Ser Lys 
    1235                 1240                 1245             


Lys Tyr  Thr Leu Ala Glu Gly  Asn Leu Glu Lys Ile  Lys Glu Leu 
    1250                 1255                 1260             


Tyr Ala  Gln Asn Asn Gly Glu  Asp Leu Lys Glu Leu  Ala Ser Ser 
    1265                 1270                 1275             


Phe Ile  Asn Leu Leu Thr Phe  Thr Ala Ile Gly Ala  Pro Ala Thr 
    1280                 1285                 1290             


Phe Lys  Phe Phe Asp Lys Asn  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1295                 1300                 1305             


Thr Thr  Glu Ile Leu Asn Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Lys Leu  Gly Gly Asp 
    1325                 1330                 1335             


<210>  650
<211>  1345
<212>  PRT
<213>  Streptococcus mutans 1SM1

<400>  650

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  651
<211>  1355
<212>  PRT
<213>  Streptococcus mutans NMT4863

<400>  651

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Ala Glu His His Glu Asp Leu Glu Lys Leu Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Asn Lys Pro Glu Leu Tyr His Asp Ile Phe Lys 
            340                 345                 350         


Asp Glu Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile Thr 
    370                 375                 380                 


Gly Ser Asp Tyr Phe Leu Asp Gln Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr His Ser Asp Glu Ala Val Thr Pro Trp Asn Phe Asp Gln 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Gln Ala Phe Ile Glu His Met Thr 
                485                 490                 495     


Asn Asn Asp Leu Tyr Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Pro Leu Tyr Glu Lys Tyr Thr Val Tyr Asn Glu Leu Thr Lys Ile Lys 
        515                 520                 525             


Tyr Val Thr Glu Ile Gly Glu Ala Lys Phe Phe Asp Ala Asn Leu Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Leu Phe Lys His Glu Arg Lys Val Thr Lys 
545                 550                 555                 560 


Lys Lys Leu Arg Thr Phe Leu Asp Lys Asn Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Ile Gln Gly Leu Asp Lys Glu Thr Glu Thr Phe Asn Ala Ser 
            580                 585                 590         


Tyr Ala Thr Tyr Gln Asp Leu Leu Lys Val Ile Lys Asp Lys Val Phe 
        595                 600                 605             


Met Asp Asn Pro Glu Asn Ala Glu Ile Leu Glu Asn Ile Val Leu Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Lys 
625                 630                 635                 640 


Tyr Ala Asp Val Phe Asp Lys Lys Val Ile Asp Gln Leu Ala Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Gln Ser Cys Lys Thr Ile Met Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Ala Gln Ser Asn Arg Asn Leu Met Gln Leu Ile Thr Asp Asp Asn Leu 
    690                 695                 700                 


Thr Phe Lys Asp Asp Ile Val Lys Ala Gln Tyr Val Asp Asn Ser Asp 
705                 710                 715                 720 


Asp Leu His Gln Val Val Gln Ser Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Lys Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Ala Lys Gly Arg Arg Asn Ser Gln Gln Arg Tyr Lys Arg 
    770                 775                 780                 


Leu Lys Glu Ala Ile Lys Ser Leu Asp Arg Asp Leu Asn His Lys Ile 
785                 790                 795                 800 


Leu Lys Glu His Pro Thr Asp Asn Gln Ala Leu Gln Asn Asn Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ser 
            820                 825                 830         


Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Ile Asp His Val Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser 
    850                 855                 860                 


Ser Lys Ala Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val 
865                 870                 875                 880 


Val Asn Arg Met Arg Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu 
                885                 890                 895     


Ile Ser Gln Arg Lys Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Leu 
            900                 905                 910         


Asp Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
        915                 920                 925             


Ile Thr Lys His Val Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu 
    930                 935                 940                 


Phe Asp Asp Asn Asn Lys Arg Ile Arg Arg Val Lys Ile Val Thr Leu 
945                 950                 955                 960 


Lys Ser Asn Leu Val Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys 
                965                 970                 975     


Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn 
            980                 985                 990         


Ala Val Val Val Lys Ala Leu Leu  Val Lys Tyr Pro Lys  Leu Glu Pro 
        995                 1000                 1005             


Glu Phe  Val Tyr Gly Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu 
    1010                 1015                 1020             


Arg Lys  Thr Ala Thr Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met 
    1025                 1030                 1035             


Asn Met  Phe Lys Ser Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val 
    1040                 1045                 1050             


Glu Arg  Pro Met Ile Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala 
    1055                 1060                 1065             


Trp Asp  Lys Thr Lys His Ile  Thr Thr Val Lys Lys  Val Leu Ser 
    1070                 1075                 1080             


Tyr Pro  Gln Val Asn Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile 
    1085                 1090                 1095             


Gly Gln  Asn Gly Gly Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu 
    1100                 1105                 1110             


Glu Val  Ile Pro Ser Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn 
    1115                 1120                 1125             


Pro Glu  Lys Tyr Gly Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro 
    1130                 1135                 1140             


Ile Leu  Leu Ile Val Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val 
    1145                 1150                 1155             


Met Asp  Lys Lys Arg Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys 
    1160                 1165                 1170             


Asp Lys  Gly Tyr Gln Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu 
    1175                 1180                 1185             


Pro Lys  Tyr Thr Leu Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu 
    1190                 1195                 1200             


Trp Ala  Ser Ser Lys Glu Val  His Lys Gly Asn Gln  Leu Val Val 
    1205                 1210                 1215             


Ser Lys  Lys Ser Gln Asp Leu  Leu Tyr His Ala His  His Leu Asp 
    1220                 1225                 1230             


Asn Asp  Tyr Ser Asn Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe 
    1235                 1240                 1245             


Asp Ile  Leu Phe Asn Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys 
    1250                 1255                 1260             


Leu Gly  Lys Glu His Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys 
    1265                 1270                 1275             


Glu Arg  Asp Phe Ala Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile 
    1280                 1285                 1290             


Lys Leu  Leu Gly Phe Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser 
    1295                 1300                 1305             


Phe Leu  Gly Ile Lys Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys 
    1310                 1315                 1320             


Asp Tyr  Leu Leu Pro Cys Met  Glu Ala Thr Leu Ile  His Gln Ser 
    1325                 1330                 1335             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly 
    1340                 1345                 1350             


Gly Asp  
    1355 


<210>  652
<211>  1337
<212>  PRT
<213>  Streptococcus parauberis KRS-02109

<400>  652

Met Lys Val Leu Gly Asn Thr Asp Arg Gln Thr Val Lys Lys Asn Met 
1               5                   10                  15      


Ile Gly Thr Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Arg Arg 
            20                  25                  30          


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Ile Asn Arg Ile 
        35                  40                  45              


Lys Tyr Leu Gln Ser Ile Phe Asp Asp Glu Met Ser Lys Ile Asp Ser 
    50                  55                  60                  


Ala Phe Phe Gln Arg Ile Lys Asp Ser Phe Leu Val Pro Asp Asp Lys 
65                  70                  75                  80  


Asn Asp Asp Arg His Pro Ile Phe Gly Asn Ile Lys Asp Glu Val Asp 
                85                  90                  95      


Tyr His Lys Asn Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala 
            100                 105                 110         


Asp Ser Asp Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
        115                 120                 125             


His Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asp 
    130                 135                 140                 


Ser Gln Asn Thr Asp Val Asn Ala Leu Phe Leu Lys Leu Val Asp Thr 
145                 150                 155                 160 


Tyr Asn Leu Met Phe Glu Asp Asp Lys Ile Asp Thr Gln Thr Ile Asp 
                165                 170                 175     


Ala Thr Val Ile Leu Thr Glu Lys Met Ser Lys Ser Arg Arg Leu Glu 
            180                 185                 190         


Asn Leu Ile Ala Lys Ile Pro Asn Gln Lys Lys Asn Thr Leu Phe Gly 
        195                 200                 205             


Asn Leu Ile Ser Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ala Asn 
    210                 215                 220                 


Phe Glu Leu Ser Glu Asp Ala Lys Leu Gln Ile Ser Lys Glu Ser Phe 
225                 230                 235                 240 


Glu Glu Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala 
                245                 250                 255     


Asp Leu Phe Ile Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser 
            260                 265                 270         


Asp Ile Leu Thr Val Lys Gly Val Asn Thr Lys Ala Pro Leu Ser Ala 
        275                 280                 285             


Ser Met Val Gln Arg Phe Asn Glu His Gln Asp Asp Leu Lys Leu Leu 
    290                 295                 300                 


Lys Lys Leu Val Lys Val Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe 
305                 310                 315                 320 


Asp Ile Lys Asp Lys Asn Gly Tyr Ala Gly Tyr Ile Asn Gly Lys Thr 
                325                 330                 335     


Ser Gln Glu Asp Phe Tyr Lys Tyr Ile Lys Pro Ile Leu Ser Lys Leu 
            340                 345                 350         


Lys Gly Ala Glu Ser Leu Ile Ser Lys Leu Glu Arg Glu Asp Phe Leu 
        355                 360                 365             


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
    370                 375                 380                 


Leu Asn Glu Leu Lys Ser Ile Ile Arg Arg Gln Glu Lys Tyr Tyr Pro 
385                 390                 395                 400 


Phe Leu Lys Asp Lys Gln Val Arg Ile Glu Lys Ile Phe Thr Phe Arg 
                405                 410                 415     


Ile Pro Tyr Phe Val Gly Pro Leu Ala Asn Gly Asn Ser Ser Phe Ala 
            420                 425                 430         


Trp Val Lys Arg Arg Ser Asn Glu Ser Ile Thr Pro Trp Asn Phe Glu 
        435                 440                 445             


Glu Val Val Glu Gln Glu Ala Ser Ala Lys Val Phe Ile Glu Arg Met 
    450                 455                 460                 


Thr Asn Phe Asp Thr Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
465                 470                 475                 480 


Ser Leu Leu Tyr Glu Met Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
                485                 490                 495     


Lys Tyr Gln Ala Glu Gly Met Arg Lys Pro Glu Phe Leu Ser Ser Glu 
            500                 505                 510         


Glu Lys Ile Glu Ile Val Ser Asn Leu Phe Lys Thr Glu Arg Lys Val 
        515                 520                 525             


Thr Val Lys Gln Leu Lys Glu Asn Tyr Phe Asn Lys Ile Arg Cys Leu 
    530                 535                 540                 


Asp Ser Ile Thr Ile Ser Gly Val Glu Asp Lys Phe Asn Ala Ser Leu 
545                 550                 555                 560 


Gly Thr Tyr His Asp Leu Leu Asn Ile Ile Lys Asn Gln Lys Ile Leu 
                565                 570                 575     


Asp Asp Glu Gln Asn Gln Asp Ser Leu Glu Asp Ile Val Leu Thr Leu 
            580                 585                 590         


Thr Leu Phe Glu Asp Glu Lys Met Ile Ala Lys Arg Leu Ser Lys Tyr 
        595                 600                 605             


Glu Ser Ile Phe Asp Pro Ser Ile Leu Lys Lys Leu Lys Lys Arg His 
    610                 615                 620                 


Tyr Thr Gly Trp Gly Arg Leu Ser Gln Lys Leu Ile Asn Gly Ile Arg 
625                 630                 635                 640 


Asp Lys Gln Thr Gly Lys Thr Ile Leu Asp Phe Leu Ile Glu Asp Gly 
                645                 650                 655     


Gln Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Pro Ser Leu Asp 
            660                 665                 670         


Phe Ala Ser Ile Ile Lys Glu Ala Gln Glu Lys Thr Ile Lys Ser Glu 
        675                 680                 685             


Lys Leu Glu Glu Thr Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys 
    690                 695                 700                 


Lys Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Val Val Lys Val 
705                 710                 715                 720 


Met Gly Tyr Glu Pro Ser Asn Ile Val Ile Glu Met Ala Arg Glu Asn 
                725                 730                 735     


Gln Ser Thr Gln Arg Gly Ile Asn Asn Ser Arg Glu Arg Leu Arg Lys 
            740                 745                 750         


Leu Glu Glu Val His Lys Asn Ile Gly Ser Lys Ile Leu Lys Glu His 
        755                 760                 765             


Glu Ile Ser Asn Ala Gln Leu Gln Ser Asp Arg Val Tyr Leu Tyr Leu 
    770                 775                 780                 


Leu Gln Asp Gly Lys Asp Met Tyr Thr Gly Lys Asp Leu Asp Phe Asp 
785                 790                 795                 800 


Arg Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ser Phe Ile 
                805                 810                 815     


Lys Asp Asn Ser Ile Asp Asn Ile Val Leu Thr Ser Gln Glu Ser Asn 
            820                 825                 830         


Arg Gly Lys Ser Asp Asn Val Pro Tyr Ile Ala Ile Val Asn Lys Met 
        835                 840                 845             


Lys Ser Tyr Trp Gln His Gln Leu Lys Ser Gly Ala Ile Ser Gln Arg 
    850                 855                 860                 


Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Tyr 
865                 870                 875                 880 


Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile 
                885                 890                 895     


Thr Lys His Val Ala Gln Ile Leu Asn Asn Arg Phe Asn Asn Asn Val 
            900                 905                 910         


Asp Asp Ser Ser Lys Asn Lys Arg Pro Val Lys Ile Ile Thr Leu Lys 
        915                 920                 925             


Ser Lys Met Val Ser Asp Phe Arg Lys Glu Phe Gly Phe Tyr Lys Ile 
    930                 935                 940                 


Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala 
945                 950                 955                 960 


Val Val Gly Thr Ala Leu Leu Lys Lys Tyr Pro Lys Leu Glu Ala Glu 
                965                 970                 975     


Phe Val Tyr Gly Asp Tyr Lys His Tyr Asp Leu Ala Ser Leu Val Val 
            980                 985                 990         


Lys Ser Asp Thr Ser Leu Gly Lys  Ala Thr Ala Lys Met  Phe Phe Tyr 
        995                 1000                 1005             


Ser Asn  Ile Met Asn Phe Phe  Lys Lys Glu Val Arg  Leu Ala Asp 
    1010                 1015                 1020             


Gly Thr  Val Ile Thr Arg Pro  Gln Ile Glu Thr Asn  Thr Glu Thr 
    1025                 1030                 1035             


Gly Glu  Ile Val Trp Asp Lys  Val Lys Asp Ile Lys  Thr Ile Arg 
    1040                 1045                 1050             


Lys Val  Leu Ser Ile Pro Gln  Ile Asn Val Val Lys  Lys Thr Glu 
    1055                 1060                 1065             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Ser Lys Arg 
    1070                 1075                 1080             


Asp Ser  Asp Lys Leu Ile Pro  Arg Lys Asn Asn Trp  Asp Pro Lys 
    1085                 1090                 1095             


Lys Tyr  Gly Gly Phe Gly Ser  Pro Ile Ile Ala Tyr  Ser Val Leu 
    1100                 1105                 1110             


Val Val  Ala Lys Val Thr Lys  Gly Lys Ser Gln Lys  Thr Lys Ser 
    1115                 1120                 1125             


Val Lys  Glu Leu Val Gly Ile  Thr Ile Met Glu Gln  Asn Glu Phe 
    1130                 1135                 1140             


Glu Lys  Asp Arg Ile Thr Phe  Leu Glu Lys Lys Gly  Tyr Gln Asp 
    1145                 1150                 1155             


Ile Gln  Glu Ser Leu Ile Ile  Lys Leu Pro Lys Phe  Ser Leu Phe 
    1160                 1165                 1170             


Glu Leu  Glu Asn Gly Arg Lys  Arg Leu Leu Ala Ser  Ala Lys Glu 
    1175                 1180                 1185             


Leu Gln  Lys Gly Asn Glu Leu  Ser Leu Pro Asn Lys  Tyr Ile Gln 
    1190                 1195                 1200             


Phe Leu  Tyr Leu Ala Ser Arg  Tyr Thr Ser Phe Ser  Gly Lys Glu 
    1205                 1210                 1215             


Glu Asp  Arg Glu Lys His Arg  His Phe Val Glu Ser  His Leu His 
    1220                 1225                 1230             


Tyr Phe  Asp Glu Ile Lys Asp  Ile Ile Ala Asp Phe  Ser Arg Arg 
    1235                 1240                 1245             


Tyr Ile  Leu Ala Asp Ala Asn  Leu Glu Lys Ile Leu  Thr Leu Tyr 
    1250                 1255                 1260             


Asn Glu  Lys Asn Gln Phe Ser  Ile Glu Glu Gln Ala  Thr Asn Met 
    1265                 1270                 1275             


Leu Asn  Leu Phe Thr Phe Thr  Gly Leu Gly Ala Pro  Ala Thr Leu 
    1280                 1285                 1290             


Lys Phe  Phe Asn Val Asp Ile  Asp Arg Lys Arg Tyr  Thr Ser Ser 
    1295                 1300                 1305             


Thr Glu  Ile Leu Asn Ser Thr  Leu Ile Arg Gln Ser  Ile Thr Gly 
    1310                 1315                 1320             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Lys Ile Gly  Gly Asp 
    1325                 1330                 1335         


<210>  653
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae FSL S3-026

<400>  653

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Tyr Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Arg Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Leu Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Arg Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Phe Leu Ala Glu Gly Phe Lys Asp Phe Gln Phe Leu Asn Arg Lys 
    530                 535                 540                 


Gln Lys Glu Thr Ile Phe Asn Ser Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Ser Phe Leu Asn Lys Val Asp Gly Tyr Glu 
                565                 570                 575     


Gly Ile Ala Ile Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Lys Lys Ile Leu Gly Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Thr Asp Asn Glu Leu Ile Leu Glu Asp Ile Val Gln Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Asp Ile Tyr Lys Asp 
625                 630                 635                 640 


Phe Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asn Lys 
            660                 665                 670         


Glu Asn Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ser Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Lys Asp Ala Gly Leu Ser Phe Lys 
    690                 695                 700                 


Pro Ile Ile Asp Lys Ala Arg Thr Gly Ser His Ser Asp Asn Leu Lys 
705                 710                 715                 720 


Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 
            740                 745                 750         


Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Leu Ser Arg Leu Arg Gln Arg Leu Thr Thr Leu Arg Glu 
    770                 775                 780                 


Ser Leu Ala Asn Leu Lys Ser Asn Ile Leu Glu Glu Lys Lys Pro Lys 
785                 790                 795                 800 


Tyr Val Lys Asp Gln Val Glu Asn His His Leu Ser Asp Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Asp Asp Glu 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Val Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Asp Asp Lys  Leu Met Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Asp Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Leu Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Gln  Lys Gln Glu Phe Val  Val Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Pro Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  654
<211>  1345
<212>  PRT
<213>  Streptococcus mutans 5SM3

<400>  654

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Phe Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ser Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Glu Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Pro Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Glu  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  655
<211>  1345
<212>  PRT
<213>  Streptococcus mutans NFSM2

<400>  655

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Gly Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  656
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae SS1014

<400>  656

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  657
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae STIR-CD-17

<400>  657

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Ser Phe Glu Asn Asn His Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Tyr Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Val 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Gln Leu Leu Asp Phe Leu Ala Lys Glu Phe Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Ile Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Arg Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Ser Asp 
        675                 680                 685             


Gly Arg Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ser Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Glu Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asp Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile Asp Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Ala Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Ile Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Pro Asp Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Lys Val Asp Asp Asn Asn Lys Pro Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Glu 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Glu Thr Gly 
    1055                 1060                 1065             


Glu Ile  Ala Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Ser Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Leu Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Lys Glu Leu Ile  Gly Ile Thr Ile Met  Glu Arg Glu 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Thr Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Tyr 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Ile Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Ser Asp Asn Lys Asp  Asn Thr Pro Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Lys Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ser Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asp Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  658
<211>  1373
<212>  PRT
<213>  Streptococcus bovis ATCC 700338

<400>  658

Met Thr Lys Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Lys Tyr Ile Lys Lys Asn Leu 
        35                  40                  45              


Leu Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Thr Lys Val Asp Glu 
                85                  90                  95      


Ser Phe Phe Gln Arg Leu Asp Glu Ser Phe Leu Arg Trp Asp Asp Asp 
            100                 105                 110         


Asn Lys Lys Leu Gly Arg Tyr Pro Ile Phe Gly Asn Lys Ala Asp Val 
        115                 120                 125             


Val Lys Tyr His Gln Glu Phe Pro Thr Ile Tyr His Leu Arg Lys His 
    130                 135                 140                 


Leu Ala Asp Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala 
145                 150                 155                 160 


Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu 
                165                 170                 175     


Leu Asn Ala Glu Asn Thr Asp Val Gln Lys Ile Phe Ala Asp Phe Val 
            180                 185                 190         


Gly Val Tyr Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr 
        195                 200                 205             


Val Asp Ala Ala Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg 
    210                 215                 220                 


Leu Glu Asn Leu Ile Lys Tyr Tyr Pro Thr Glu Lys Lys Asn Thr Leu 
225                 230                 235                 240 


Phe Gly Asn Leu Ile Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys 
                245                 250                 255     


Met Asn Phe Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp 
            260                 265                 270         


Ser Tyr Glu Glu Asp Leu Gly Glu Leu Leu Gly Lys Ile Gly Asp Asp 
        275                 280                 285             


Tyr Ala Asp Leu Phe Thr Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu 
    290                 295                 300                 


Leu Ser Gly Ile Leu Ile Val Asp Asp Asn Ser Thr Lys Ala Pro Leu 
305                 310                 315                 320 


Ser Ala Ser Met Ile Lys Arg Tyr Val Glu His Gln Glu Asp Leu Glu 
                325                 330                 335     


Lys Leu Lys Glu Phe Ile Lys Ala Asn Lys Ser Glu Leu Tyr His Asp 
            340                 345                 350         


Ile Phe Lys Asp Lys Asn Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn 
        355                 360                 365             


Gly Val Lys Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser 
    370                 375                 380                 


Lys Ile Ala Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp 
385                 390                 395                 400 


Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
                405                 410                 415     


Ile His Leu Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr 
            420                 425                 430         


Tyr Pro Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr 
        435                 440                 445             


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asp Ser Arg 
    450                 455                 460                 


Phe Ser Trp Ala Glu Tyr His Ser Asp Glu Lys Ile Thr Pro Trp Asn 
465                 470                 475                 480 


Phe Asp Lys Val Ile Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr 
                485                 490                 495     


Arg Met Thr Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro 
            500                 505                 510         


Lys His Ser His Val Tyr Glu Thr Tyr Ala Val Tyr Asn Glu Leu Thr 
        515                 520                 525             


Lys Ile Lys Tyr Val Asn Glu Gln Gly Lys Asp Ser Phe Phe Asp Ser 
    530                 535                 540                 


Asn Met Lys Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys 
545                 550                 555                 560 


Val Thr Lys Glu Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Pro Glu 
                565                 570                 575     


Tyr Arg Ile Lys Asp Leu Ile Gly Leu Asp Lys Glu Asn Lys Ser Phe 
            580                 585                 590         


Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys 
        595                 600                 605             


Ala Phe Leu Asp Asp Lys Val Asn Glu Glu Val Ile Glu Asp Ile Ile 
    610                 615                 620                 


Lys Thr Leu Thr Leu Phe Glu Asp Lys Asp Met Ile His Glu Arg Leu 
625                 630                 635                 640 


Gln Lys Tyr Ser Asp Ile Phe Thr Ala Asp Gln Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn 
            660                 665                 670         


Gly Ile Arg Asn Lys Glu Asn Asn Lys Thr Ile Leu Asp Tyr Leu Ile 
        675                 680                 685             


Asp Asp Gly Ser Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp 
    690                 695                 700                 


Thr Leu Pro Phe Lys Gln Ile Ile Gln Lys Ser Gln Val Val Gly Asp 
705                 710                 715                 720 


Val Asp Asp Ile Glu Ala Val Val His Asp Leu Pro Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Lys Val Met Gly Asp Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Asn Arg Gly Arg Ser Gln Ser Gln Gln Arg Leu 
    770                 775                 780                 


Lys Lys Leu Gln Asn Ser Leu Lys Glu Leu Gly Ser Asn Ile Leu Asn 
785                 790                 795                 800 


Glu Glu Lys Pro Ser Tyr Ile Glu Asp Lys Val Glu Asn Ser His Leu 
                805                 810                 815     


Gln Asn Asp Gln Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met 
            820                 825                 830         


Tyr Thr Gly Asp Glu Leu Asp Ile Asp His Leu Ser Asp Tyr Asp Ile 
        835                 840                 845             


Asp His Ile Ile Pro Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn 
    850                 855                 860                 


Arg Val Leu Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val 
865                 870                 875                 880 


Pro Ser Leu Asp Ile Val Arg Ala Arg Lys Ala Glu Trp Val Arg Leu 
                885                 890                 895     


Tyr Lys Ser Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys 
            900                 905                 910         


Ala Glu Arg Gly Gly Leu Thr Glu Ala Asp Lys Ala Gly Phe Ile Lys 
        915                 920                 925             


Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile 
    930                 935                 940                 


Leu Asp Ala Arg Phe Asn Thr Glu Ser Asp Glu Asn Asp Lys Val Ile 
945                 950                 955                 960 


Arg Asp Val Lys Val Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe 
                965                 970                 975     


Arg Lys Asp Phe Glu Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His 
            980                 985                 990         


His Ala His Asp Ala Tyr Leu Asn  Ala Val Val Gly Thr  Ala Leu Leu 
        995                 1000                 1005             


Lys Lys  Tyr Pro Lys Leu Ala  Ser Glu Phe Val Tyr  Gly Glu Tyr 
    1010                 1015                 1020             


Lys Lys  Tyr Asp Ile Arg Lys  Phe Ile Thr Asn Ser  Ser Asp Lys 
    1025                 1030                 1035             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Leu Met  Asn Phe Phe 
    1040                 1045                 1050             


Lys Arg  Val Ile Arg Tyr Ser  Asn Gly Lys Val Ile  Val Arg Pro 
    1055                 1060                 1065             


Val Val  Glu Tyr Ser Lys Asp  Thr Glu Asp Ile Ala  Trp Asp Lys 
    1070                 1075                 1080             


Lys Ser  Asn Phe Arg Thr Ile  Cys Lys Val Leu Ser  Tyr Pro Gln 
    1085                 1090                 1095             


Val Asn  Ile Val Lys Lys Val  Glu Thr Gln Thr Gly  Gly Phe Ser 
    1100                 1105                 1110             


Lys Glu  Ser Ile Leu Pro Lys  Gly Asp Ser Asp Lys  Leu Ile Pro 
    1115                 1120                 1125             


Arg Lys  Thr Lys Lys Ala Tyr  Trp Asp Thr Lys Lys  Tyr Gly Gly 
    1130                 1135                 1140             


Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val Phe Val  Val Ala Asp 
    1145                 1150                 1155             


Val Glu  Lys Gly Lys Ala Lys  Lys Leu Lys Thr Val  Lys Glu Leu 
    1160                 1165                 1170             


Val Gly  Ile Ser Ile Met Glu  Arg Ser Phe Phe Glu  Glu Asn Pro 
    1175                 1180                 1185             


Val Glu  Phe Leu Glu Asn Lys  Gly Tyr His Asn Ile  Arg Glu Asp 
    1190                 1195                 1200             


Lys Leu  Ile Lys Leu Pro Lys  Tyr Ser Leu Phe Glu  Phe Glu Gly 
    1205                 1210                 1215             


Gly Lys  Arg Arg Leu Leu Ala  Ser Ala Ser Glu Leu  Gln Lys Gly 
    1220                 1225                 1230             


Asn Glu  Met Val Ile Pro Gly  His Leu Val Lys Leu  Leu Tyr His 
    1235                 1240                 1245             


Ala Gln  Arg Ile Asn Ser Phe  Asn Ser Thr Lys Tyr  Leu Asp Tyr 
    1250                 1255                 1260             


Val Ser  Ala His Lys Lys Glu  Phe Glu Lys Val Leu  Ser Cys Val 
    1265                 1270                 1275             


Glu Asp  Phe Ala Asn Leu Tyr  Val Asp Val Glu Lys  Asn Leu Ser 
    1280                 1285                 1290             


Lys Ile  Arg Ala Val Ala Asp  Ser Met Asp Asn Phe  Ser Ile Glu 
    1295                 1300                 1305             


Glu Ile  Ser Asn Ser Phe Ile  Asn Leu Leu Thr Leu  Thr Ala Leu 
    1310                 1315                 1320             


Gly Ala  Pro Ala Asp Phe Asn  Phe Leu Gly Glu Lys  Ile Pro Arg 
    1325                 1330                 1335             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Cys Leu Asn Ala  Thr Leu Ile 
    1340                 1345                 1350             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1355                 1360                 1365             


Lys Ile  Gly Glu Glu 
    1370             


<210>  659
<211>  1345
<212>  PRT
<213>  Streptococcus mutans 3SN1

<400>  659

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  660
<211>  1326
<212>  PRT
<213>  Streptococcus pseudoporcinus SPIN 20026

<400>  660

Met Leu Gly Thr Val Leu Phe Asp Ser Gly Glu Thr Ala Gln Ala Arg 
1               5                   10                  15      


Arg Leu Lys Arg Thr Asn Arg Arg Arg Tyr Thr Arg Arg Arg Tyr Arg 
            20                  25                  30          


Leu Cys Gln Leu Gln Asn Ile Phe Ala Thr Glu Met Val Lys Val Asp 
        35                  40                  45              


Asp Thr Phe Phe Gln Arg Leu Ser Glu Ser Phe Phe Tyr Tyr Gln Asp 
    50                  55                  60                  


Lys Ala Phe Asp Lys His Pro Ile Phe Gly Asn Ser Lys Glu Glu Arg 
65                  70                  75                  80  


Ala Tyr His Lys Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Asp Leu 
                85                  90                  95      


Ala Asp Arg Asp Gln Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu 
            100                 105                 110         


Ser His Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Leu 
        115                 120                 125             


Asn Ser Glu Asn Thr Asp Val Gln Lys Leu Phe Ile Ala Leu Val Thr 
    130                 135                 140                 


Val Tyr Asn Leu Leu Phe Glu Glu Glu Pro Ile Ala Gly Glu Thr Cys 
145                 150                 155                 160 


Asp Ala Lys Ala Leu Leu Thr Ala Lys Thr Ser Lys Ser Lys Arg Leu 
                165                 170                 175     


Glu Ser Leu Ile Ser Glu Phe Pro Gly Gln Lys Lys Asn Gly Leu Phe 
            180                 185                 190         


Gly Asn Leu Leu Ala Leu Ala Leu Gly Leu Arg Pro Asn Phe Lys Ser 
        195                 200                 205             


Asn Phe Gly Leu Ser Glu Asp Ala Lys Leu Gln Ile Thr Lys Asp Thr 
    210                 215                 220                 


Tyr Glu Glu Glu Leu Asp Asn Leu Leu Ala Glu Ile Gly Asp His Tyr 
225                 230                 235                 240 


Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu 
                245                 250                 255     


Ser Asp Ile Leu Thr Leu Ser Asp Glu Asn Thr Arg Ala Pro Leu Ser 
            260                 265                 270         


Ala Ser Met Ile Lys Arg Tyr Glu Glu His Gln Glu Asp Leu Ala Leu 
        275                 280                 285             


Leu Lys Lys Leu Val Lys Glu Gln Met Pro Glu Lys Tyr Trp Glu Ile 
    290                 295                 300                 


Phe Ser Asn Ala Lys Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Gly Lys 
305                 310                 315                 320 


Val Ser Gln Glu Asp Phe Tyr Arg Tyr Ile Lys Pro Ile Leu Ser Arg 
                325                 330                 335     


Leu Lys Gly Gly Asp Glu Phe Leu Ala Lys Ile Asp Arg Asp Asp Phe 
            340                 345                 350         


Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile 
        355                 360                 365             


His Leu Lys Glu Leu His Ala Ile Leu Arg Arg Gln Glu Lys Tyr Tyr 
    370                 375                 380                 


Pro Phe Leu Ala Glu Gln Lys Glu Lys Ile Glu Gln Leu Leu Cys Phe 
385                 390                 395                 400 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Gly Gly Asn Ser Ser 
                405                 410                 415     


Phe Ala Trp Leu Lys Arg Arg Ser Asp Glu Pro Ile Thr Pro Trp Asn 
            420                 425                 430         


Phe Lys Asp Val Val Asp Glu Glu Ala Ser Ala Gln Ala Phe Ile Glu 
        435                 440                 445             


Gly Met Thr Asn Tyr Asp Thr Tyr Leu Pro Glu Glu Lys Val Leu Pro 
    450                 455                 460                 


Lys His Ser Pro Leu Tyr Glu Met Phe Thr Val Tyr Asn Glu Leu Thr 
465                 470                 475                 480 


Lys Val Lys Tyr Ile Ala Glu Asn Met Thr Lys Pro Leu Tyr Leu Ser 
                485                 490                 495     


Ala Glu Gln Lys Glu Ala Ile Ile Asp His Leu Phe Lys Gln Thr Arg 
            500                 505                 510         


Lys Val Thr Val Lys Asp Leu Lys Glu Lys Tyr Phe Ser Gln Ile Glu 
        515                 520                 525             


Gly Leu Glu Asn Val Asp Val Thr Gly Val Glu Gly Ala Phe Asn Ala 
    530                 535                 540                 


Ser Leu Gly Thr Tyr Asn Asp Leu Leu Lys Ile Ile Lys Asp Lys Ala 
545                 550                 555                 560 


Phe Leu Asp Asp Glu Ala Asn Ala Glu Ile Leu Glu Glu Ile Val Leu 
                565                 570                 575     


Ile Leu Thr Leu Phe Gln Asp Glu Lys Leu Ile Glu Lys Arg Leu Ala 
            580                 585                 590         


Lys Tyr Ala Asn Leu Phe Glu Lys Ser Val Leu Lys Lys Leu Arg Lys 
        595                 600                 605             


Arg His Tyr Arg Gly Trp Gly Arg Leu Ser Arg Gln Leu Ile Asp Gly 
    610                 615                 620                 


Met Lys Asp Lys Ala Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ala 
625                 630                 635                 640 


Asp Asp Phe Ala Asn Arg Asn Phe Ile Gln Leu Ile Asn Asp Ser Ser 
                645                 650                 655     


Leu Asp Phe Glu Lys Leu Ile Asp Asp Ala Gln Lys Lys Ala Ile Lys 
            660                 665                 670         


Arg Glu Ser Leu Thr Glu Ala Val Ala Asn Leu Ala Gly Ser Pro Ala 
        675                 680                 685             


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Val Val Asp Glu Ile Val 
    690                 695                 700                 


Lys Val Met Gly His Asn Pro Asp Asn Ile Val Ile Glu Met Ser Arg 
705                 710                 715                 720 


Glu Asn Gln Thr Thr Ala Gln Gly Leu Lys Asn Ala Arg Gln Arg Leu 
                725                 730                 735     


Lys Lys Ile Lys Glu Val His Lys Lys Thr Gly Ser Arg Ile Leu Glu 
            740                 745                 750         


Asp Asn Ser Glu Arg Ile Thr Asn Leu Thr Leu Gln Asp Asn Arg Leu 
        755                 760                 765             


Tyr Leu Tyr Leu Leu Gln Asp Gly Lys Asp Met Tyr Thr Gly Gln Asp 
    770                 775                 780                 


Leu Asp Ile Asn Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
785                 790                 795                 800 


Gln Ser Phe Ile Lys Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Thr 
                805                 810                 815     


Gln Lys Ala Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Glu Val 
            820                 825                 830         


Val Arg Asp Met Lys Asp Arg Val Trp Arg Arg Gln Leu Ala Asn Gly 
        835                 840                 845             


Ala Ile Ser Arg Gln Lys Phe Asp His Leu Thr Lys Ala Glu Arg Gly 
    850                 855                 860                 


Gly Leu Ala Asp Ser Asp Lys Ala Arg Phe Leu Arg Arg Gln Leu Val 
865                 870                 875                 880 


Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Leu Leu Asp Ser Arg 
                885                 890                 895     


Phe Asn Ser Lys Ser Asn Gln Asn Lys Lys Leu Ala Arg Asn Val Lys 
            900                 905                 910         


Ile Ile Thr Leu Lys Ser Lys Ile Val Ser Asp Phe Arg Lys Asp Phe 
        915                 920                 925             


Gly Leu Tyr Lys Leu Arg Glu Val Asn Asn Tyr His His Ala His Asp 
    930                 935                 940                 


Ala Tyr Leu Asn Ala Val Val Gly Thr Ala Leu Leu Lys Lys Tyr Pro 
945                 950                 955                 960 


Lys Leu Glu Ala Glu Phe Val Tyr Gly Asp Tyr Lys His Phe Asp Leu 
                965                 970                 975     


Val Lys Leu Ile Ser Lys Ser Asp Pro Ser Leu Gly Lys Ala Thr Ala 
            980                 985                 990         


Lys Val Phe Phe Tyr Ser Asn Ile  Met Asn Phe Phe Lys  Glu Glu Leu 
        995                 1000                 1005             


Ser Leu  Ala Asp Gly Thr Leu  Met Lys Arg Pro Val  Ile Glu Thr 
    1010                 1015                 1020             


Asn Thr  Glu Thr Gly Glu Val  Val Trp Asp Lys Val  Lys Asp Phe 
    1025                 1030                 1035             


Lys Thr  Ile Arg Lys Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val 
    1040                 1045                 1050             


Lys Lys  Thr Glu Ile Gln Ser  Gly Ala Phe Ser Lys  Glu Ser Val 
    1055                 1060                 1065             


Leu Ser  Lys Gly Asn Ser Asp  Lys Leu Ile Glu Arg  Lys Lys Gly 
    1070                 1075                 1080             


Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp Ser Pro  Asn Thr Ala 
    1085                 1090                 1095             


Tyr Ser  Ile Phe Val Val Ala  Lys Val Ala Lys Arg  Lys Ala Gln 
    1100                 1105                 1110             


Lys Leu  Lys Thr Val Lys Glu  Ile Val Gly Ile Thr  Ile Met Glu 
    1115                 1120                 1125             


Gln Ala  Glu Tyr Glu Lys Asp  Asn Ile Ala Phe Leu  Glu Lys Lys 
    1130                 1135                 1140             


Gly Tyr  Gln Asp Ile Gln Glu  Lys Leu Leu Ile Lys  Leu Pro Lys 
    1145                 1150                 1155             


Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg Arg Arg  Leu Leu Ala 
    1160                 1165                 1170             


Ser Ala  Asn Glu Phe Gln Lys  Gly Asn Glu Leu Ala  Leu Ser Gly 
    1175                 1180                 1185             


Lys Tyr  Met Lys Phe Leu Tyr  Leu Ala Ser Arg Tyr  Asp Lys Leu 
    1190                 1195                 1200             


Ser Ser  Lys Ile Glu Ser Glu  Gln Gln Lys Lys Leu  Phe Val Glu 
    1205                 1210                 1215             


Gln His  Leu His Tyr Phe Asp  Glu Ile Leu Asp Ile  Val Val Lys 
    1220                 1225                 1230             


His Ala  Thr Cys Tyr Ile Lys  Ala Glu Asn Asn Leu  Lys Lys Ile 
    1235                 1240                 1245             


Ile Ser  Leu Tyr Lys Lys Lys  Glu Ala Tyr Ser Ile  Asn Glu Gln 
    1250                 1255                 1260             


Ala Leu  Asn Met Leu Asn Leu  Phe Ile Phe Thr Ser  Leu Gly Ala 
    1265                 1270                 1275             


Pro Ser  Thr Phe Val Phe Phe  Asp Glu Thr Ile Asp  Arg Lys Arg 
    1280                 1285                 1290             


Tyr Thr  Thr Ser Ser Asp Val  Leu Asn Gly Ile Leu  Ile Gln Gln 
    1295                 1300                 1305             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Arg Phe 
    1310                 1315                 1320             


Gly Gly  Asp 
    1325     


<210>  661
<211>  1345
<212>  PRT
<213>  Streptococcus mutans R221

<400>  661

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Asn  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  662
<211>  1345
<212>  PRT
<213>  Streptococcus mutans N3209

<400>  662

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Thr Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Cys Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Thr Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Ser Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  663
<211>  1345
<212>  PRT
<213>  Streptococcus mutans NLML1

<400>  663

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Arg Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  664
<211>  1345
<212>  PRT
<213>  Streptococcus mutans N29

<400>  664

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ser Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Ala  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  665
<211>  1377
<212>  PRT
<213>  Streptococcus equinus ATCC 9812

<400>  665

Met Glu Lys Thr Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Ala Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Lys Glu Met Ala Lys Val Asp Glu Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Glu Glu Ser Phe Leu Thr Asp Asp Asp Lys Thr 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Thr Tyr 
        115                 120                 125             


His Gln Glu Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gln Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Ile Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ala Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Lys Gln Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Val Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Ala Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Glu Glu His His Glu Asp Leu Glu Lys Leu Lys 
                325                 330                 335     


Thr Phe Ile Lys Val Asn Asn Phe Asp Lys Tyr His Glu Ile Phe Lys 
            340                 345                 350         


Asp Lys Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Ile Phe Tyr Lys His Leu Lys Ser Ile Ile Ser Glu Lys Asn 
    370                 375                 380                 


Gly Gly Gln Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Thr Ile Leu Arg Arg Gln Gly Glu Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Ala Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Lys Tyr His Ser Asp Glu Pro Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Val Val Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr 
                485                 490                 495     


Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Tyr Val Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Ile Lys 
        515                 520                 525             


Tyr Val Asn Glu Gln Gly Lys Ser Phe Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys 
545                 550                 555                 560 


Ala Lys Leu Leu Ser Tyr Leu Asn Asn Glu Phe Glu Glu Phe Arg Ile 
                565                 570                 575     


Asn Asp Leu Ile Gly Leu Asp Lys Asp Ser Lys Ser Phe Asn Ala Ser 
            580                 585                 590         


Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Ser Phe Leu 
        595                 600                 605             


Asp Asp Lys Thr Asn Glu Gln Ile Ile Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Asp Met Ile His Glu Arg Leu Gln Lys Tyr 
625                 630                 635                 640 


Ser Asp Ile Phe Thr Ser Gln Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Asn Asn Lys Thr Ile Leu Asp Phe Leu Ile Asp Asp Gly 
        675                 680                 685             


Asp Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Ser 
    690                 695                 700                 


Phe Lys Thr Thr Ile Gln Glu Ala Gln Val Val Gly Asp Val Asp Asp 
705                 710                 715                 720 


Ile Glu Ala Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly His Asn Pro Gln Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Ile Thr Gly Tyr Gly Arg Asn Arg Ser Asn Gln Arg Leu Lys Arg Leu 
    770                 775                 780                 


Gln Asp Ser Leu Lys Glu Phe Gly Ser Asp Ile Leu Ser Lys Lys Lys 
785                 790                 795                 800 


Pro Ser Tyr Val Asp Ser Lys Val Glu Asn Ser His Leu Gln Asn Asp 
                805                 810                 815     


Arg Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met Tyr Thr Gly 
            820                 825                 830         


Glu Glu Leu Asp Ile Asp His Leu Ser Asp Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg Val Leu 
    850                 855                 860                 


Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile 
865                 870                 875                 880 


Glu Ile Val Arg Asn Arg Lys Ser Tyr Trp Tyr Lys Leu Tyr Lys Ser 
                885                 890                 895     


Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Thr Glu Thr Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala 
    930                 935                 940                 


Arg Phe Asn Thr Lys Cys Asp Glu Asn Asp Lys Val Ile Arg Asp Val 
945                 950                 955                 960 


Lys Val Ile Thr Leu Lys Ser Ser Leu Val Ser Gln Phe Arg Lys Glu 
                965                 970                 975     


Phe Lys Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Val  Gly Thr Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Ala Pro Glu Phe  Val Tyr Gly Glu Tyr  Lys Lys Tyr 
    1010                 1015                 1020             


Asp Val  Arg Lys Leu Val Ala  Lys Ser Ser Asp Asn  His Ser Glu 
    1025                 1030                 1035             


Leu Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe Tyr Ser  Asn Leu Met 
    1040                 1045                 1050             


Asn Phe  Phe Lys Thr Glu Val  Lys Tyr Ala Asp Gly  Arg Val Phe 
    1055                 1060                 1065             


Glu Arg  Pro Asp Ile Glu Thr  Asn Ala Asp Gly Glu  Val Val Trp 
    1070                 1075                 1080             


Asn Lys  Gln Arg Asp Phe Asn  Ile Val Arg Lys Val  Leu Ser Tyr 
    1085                 1090                 1095             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Val Gln  Thr Gly Gly 
    1100                 1105                 1110             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu 
    1115                 1120                 1125             


Ile Pro  Arg Lys Thr Lys Lys  Leu Gln Trp Glu Thr  Gln Lys Tyr 
    1130                 1135                 1140             


Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr Ser Val  Leu Val Val 
    1145                 1150                 1155             


Ala Asp  Val Glu Lys Gly Lys  Thr Arg Lys Leu Lys  Thr Val Lys 
    1160                 1165                 1170             


Glu Leu  Val Gly Ile Ser Ile  Met Glu Arg Ser Ser  Phe Glu Glu 
    1175                 1180                 1185             


Asn Pro  Val Ser Phe Leu Glu  Lys Lys Gly Tyr His  Asn Val Gln 
    1190                 1195                 1200             


Glu Asp  Lys Leu Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Phe 
    1205                 1210                 1215             


Glu Gly  Gly Arg Arg Arg Leu  Leu Ala Ser Ala Thr  Glu Leu Gln 
    1220                 1225                 1230             


Lys Gly  Asn Glu Val Val Leu  Pro Gln Tyr Met Val  Asn Leu Leu 
    1235                 1240                 1245             


Tyr His  Ser Gln His Val Asn  Asn Ser His Lys Pro  Glu His Leu 
    1250                 1255                 1260             


Asn Tyr  Val Lys Gln His Lys  Asp Glu Phe Lys Asp  Ile Phe Asn 
    1265                 1270                 1275             


Leu Ile  Ile Ser Ile Ala Arg  Ile Asn Ile Leu Lys  Pro Lys Val 
    1280                 1285                 1290             


Val Asp  Asn Leu Ile Asn Glu  Phe Thr Glu Tyr Gly  Gln Glu Asp 
    1295                 1300                 1305             


Ile Ser  Ser Leu Ser Glu Ser  Phe Ile Asn Leu Leu  Lys Phe Ile 
    1310                 1315                 1320             


Ser Phe  Gly Ala Pro Gly Ala  Phe Lys Phe Leu Lys  Leu Asp Val 
    1325                 1330                 1335             


Lys Gln  Ser Asn Leu Arg Tyr  Lys Ser Thr Thr Glu  Ala Leu Ser 
    1340                 1345                 1350             


Ala Thr  Leu Ile His Gln Ser  Val Thr Gly Leu Tyr  Glu Thr Arg 
    1355                 1360                 1365             


Ile Asp  Leu Ser Lys Leu Gly  Glu Glu 
    1370                 1375         


<210>  666
<211>  1345
<212>  PRT
<213>  Streptococcus mutans NVAB

<400>  666

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  667
<211>  1373
<212>  PRT
<213>  Streptococcus oralis SK304

<400>  667

Met Glu Asn Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Arg Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Ala Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Ile Pro Glu Asp Lys 
            100                 105                 110         


Lys Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Ile Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Asp Thr Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asn Asn Thr Phe Glu Gly Asn Ser Leu Ser Gly Gln Asn Val Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 
    210                 215                 220                 


Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Arg Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Val Ala Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Thr Leu 
                325                 330                 335     


Lys Gln Phe Ile Lys Thr Asn Leu Pro Glu Lys Tyr Asp Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ser Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Glu Gly Ala Asp Tyr Phe Leu Glu Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Ser Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Arg 
    530                 535                 540                 


Gln Lys Lys Asp Ile Phe Tyr Thr Leu Phe Lys Ala Glu Asp Lys Arg 
545                 550                 555                 560 


Lys Val Thr Glu Lys Asp Ile Ile Gln Tyr Leu His Thr Val Asp Gly 
                565                 570                 575     


Tyr Asp Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser 
            580                 585                 590         


Leu Ser Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe 
        595                 600                 605             


Met Asp Asp Pro Asn Asn Glu Glu Ile Leu Glu Asn Ile Val His Thr 
    610                 615                 620                 


Leu Thr Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln 
625                 630                 635                 640 


Tyr Asp Ser Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Lys Leu Ser Ser Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Gln Thr Gly Lys Thr Ile Leu Asp Tyr Leu Met Asp Asp 
        675                 680                 685             


Gly Tyr Asn Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Glu Leu 
    690                 695                 700                 


Ser Phe Lys Glu Ile Ile Lys Lys Ala Gln Val Val Gly Lys Thr Asp 
705                 710                 715                 720 


Asp Val Lys Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Ile Lys Leu Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly His Glu Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg 
    770                 775                 780                 


Ile Glu Asp Ser Leu Lys Ile Leu Ala Ser Gly Leu Asn Ala Lys Ile 
785                 790                 795                 800 


Leu Lys Glu His Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Lys Pro 
            820                 825                 830         


Leu Asp Ile Asn Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser 
    850                 855                 860                 


Leu Lys Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val 
865                 870                 875                 880 


Val Glu Lys Met Lys Thr Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu 
                885                 890                 895     


Ile Ser Tyr Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Asp Glu Arg Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala Arg Tyr 
    930                 935                 940                 


Asn Thr Glu Val Asn Glu Lys Asp Lys Lys Asn Arg Thr Val Lys Ile 
945                 950                 955                 960 


Ile Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Arg 
                965                 970                 975     


Leu Tyr Lys Ile Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Lys Lys  Tyr Pro Lys 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Gln Lys  Tyr Asp Leu 
    1010                 1015                 1020             


Lys Arg  Tyr Ile Ser Arg Ser  Lys Asp Pro Lys Glu  Ile Glu Lys 
    1025                 1030                 1035             


Ala Thr  Glu Lys Tyr Phe Phe  Tyr Ser Asn Leu Leu  Asn Phe Phe 
    1040                 1045                 1050             


Lys Glu  Glu Val His Tyr Ala  Asp Gly Thr Ile Val  Lys Arg Glu 
    1055                 1060                 1065             


Asn Ile  Glu Tyr Ser Lys Asp  Thr Gly Glu Ile Ala  Trp Asn Lys 
    1070                 1075                 1080             


Glu Lys  Asp Phe Ala Thr Ile  Lys Lys Val Leu Ser  Leu Pro Gln 
    1085                 1090                 1095             


Val Asn  Ile Val Lys Lys Arg  Glu Val Gln Thr Gly  Gly Phe Ser 
    1100                 1105                 1110             


Lys Glu  Ser Ile Leu Pro Lys  Gly Asn Ser Asp Lys  Leu Ile Pro 
    1115                 1120                 1125             


Arg Lys  Thr Lys Asp Ile Leu  Trp Asp Thr Thr Lys  Tyr Gly Gly 
    1130                 1135                 1140             


Phe Asp  Ser Pro Val Ile Ala  Tyr Ser Ile Leu Leu  Ile Ala Asp 
    1145                 1150                 1155             


Ile Glu  Lys Gly Lys Ala Lys  Arg Leu Lys Thr Val  Lys Thr Leu 
    1160                 1165                 1170             


Val Gly  Ile Thr Ile Met Glu  Lys Ala Thr Phe Glu  Lys Ser Pro 
    1175                 1180                 1185             


Ile Ala  Phe Leu Glu Asn Lys  Gly Tyr His Asn Val  Arg Lys Glu 
    1190                 1195                 1200             


Asn Ile  Leu Cys Leu Pro Lys  Tyr Ser Leu Phe Glu  Leu Lys Asn 
    1205                 1210                 1215             


Gly Arg  Arg Arg Met Leu Ala  Ser Ala Lys Glu Leu  Gln Lys Gly 
    1220                 1225                 1230             


Asn Glu  Ile Val Leu Pro Val  His Leu Thr Thr Leu  Leu Tyr His 
    1235                 1240                 1245             


Ala Lys  Asn Ile His Arg Leu  Asp Glu Pro Glu His  Leu Glu Tyr 
    1250                 1255                 1260             


Ile Gln  Lys His Arg Asn Glu  Phe Lys Gly Leu Leu  Asn Leu Val 
    1265                 1270                 1275             


Ser Glu  Phe Ser Gln Lys Tyr  Val Leu Ala Asp Ala  Asn Leu Glu 
    1280                 1285                 1290             


Lys Ile  Lys Asn Leu Tyr Ala  Asp Asn Glu Gln Ala  Asp Ile Glu 
    1295                 1300                 1305             


Ile Leu  Ala Asn Ser Phe Ile  Asn Leu Leu Thr Phe  Thr Ala Leu 
    1310                 1315                 1320             


Gly Ala  Pro Ala Ala Phe Lys  Phe Phe Gly Lys Asp  Val Asp Arg 
    1325                 1330                 1335             


Lys Arg  Tyr Thr Thr Val Ser  Glu Ile Leu Asn Ala  Thr Leu Ile 
    1340                 1345                 1350             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1355                 1360                 1365             


Lys Leu  Gly Glu Asp 
    1370             


<210>  668
<211>  1355
<212>  PRT
<213>  Streptococcus mutans 15VF2

<400>  668

Met Lys Lys Ser Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Ala Glu His His Glu Asp Leu Glu Lys Leu Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Asn Lys Pro Glu Leu Tyr His Asp Ile Phe Lys 
            340                 345                 350         


Asp Glu Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile Ala 
    370                 375                 380                 


Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr His Ser Asp Glu Ala Val Met Pro Trp Asn Phe Asp Gln 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Gln Ala Phe Ile Glu His Met Thr 
                485                 490                 495     


Asn Asn Asp Leu Tyr Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Pro Leu Tyr Glu Lys Tyr Thr Val Tyr Asn Glu Leu Thr Lys Ile Lys 
        515                 520                 525             


Tyr Val Thr Glu Ile Gly Glu Ala Lys Phe Phe Asp Ala Asn Leu Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Leu Phe Lys His Glu Arg Lys Val Thr Lys 
545                 550                 555                 560 


Lys Lys Leu Arg Thr Phe Leu Asp Lys Asn Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Ile Gln Gly Leu Asp Lys Glu Thr Glu Thr Phe Asn Ala Ser 
            580                 585                 590         


Tyr Ala Thr Tyr Gln Asp Leu Leu Lys Val Ile Lys Asp Lys Val Phe 
        595                 600                 605             


Met Asp Asn Pro Glu Asn Ala Glu Ile Leu Glu Asn Ile Val Leu Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Lys 
625                 630                 635                 640 


Tyr Ala Asp Val Phe Asp Lys Lys Val Ile Asp Gln Leu Ala Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Gln Ser Cys Lys Thr Ile Met Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Ala Gln Ser Asn Arg Asn Leu Met Gln Leu Ile Thr Asp Asp Asn Leu 
    690                 695                 700                 


Thr Phe Lys Asp Asp Ile Val Lys Ala Gln Tyr Val Asp Asn Ser Asp 
705                 710                 715                 720 


Asp Leu His Gln Val Val Gln Ser Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Lys Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Ala Lys Gly Arg Arg Asn Ser Gln Gln Arg Tyr Lys Arg 
    770                 775                 780                 


Leu Lys Glu Ala Ile Lys Ser Leu Asp Arg Asp Leu Asn His Lys Ile 
785                 790                 795                 800 


Leu Lys Glu His Pro Thr Asp Asn Gln Ala Leu Gln Asn Asn Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ser 
            820                 825                 830         


Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Ile Asp His Val Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser 
    850                 855                 860                 


Ser Lys Ala Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val 
865                 870                 875                 880 


Val Asn Arg Met Arg Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu 
                885                 890                 895     


Ile Ser Gln Arg Lys Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Pro 
            900                 905                 910         


Asp Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
        915                 920                 925             


Ile Thr Lys His Val Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu 
    930                 935                 940                 


Phe Asp Asp Asn Asn Lys Arg Ile Arg Arg Val Lys Ile Val Thr Leu 
945                 950                 955                 960 


Lys Ser Asn Leu Val Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys 
                965                 970                 975     


Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn 
            980                 985                 990         


Ala Val Val Val Lys Ala Leu Leu  Val Lys Tyr Pro Lys  Leu Glu Pro 
        995                 1000                 1005             


Glu Phe  Val Tyr Gly Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu 
    1010                 1015                 1020             


Arg Lys  Thr Ala Thr Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met 
    1025                 1030                 1035             


Asn Met  Phe Lys Ser Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val 
    1040                 1045                 1050             


Glu Arg  Pro Met Ile Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala 
    1055                 1060                 1065             


Trp Asp  Lys Thr Lys His Ile  Thr Thr Val Lys Lys  Val Leu Ser 
    1070                 1075                 1080             


Tyr Pro  Gln Val Asn Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile 
    1085                 1090                 1095             


Gly Gln  Asn Gly Gly Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu 
    1100                 1105                 1110             


Glu Val  Ile Pro Ser Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn 
    1115                 1120                 1125             


Pro Glu  Lys Tyr Gly Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro 
    1130                 1135                 1140             


Ile Leu  Leu Ile Val Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val 
    1145                 1150                 1155             


Met Asp  Lys Lys Arg Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys 
    1160                 1165                 1170             


Asp Lys  Gly Tyr Gln Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu 
    1175                 1180                 1185             


Pro Lys  Tyr Thr Leu Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu 
    1190                 1195                 1200             


Trp Ala  Ser Ser Lys Glu Val  His Lys Gly Asn Gln  Leu Val Val 
    1205                 1210                 1215             


Ser Lys  Lys Ser Gln Asp Leu  Leu Tyr His Ala His  His Leu Asp 
    1220                 1225                 1230             


Asn Asp  Tyr Ser Asn Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe 
    1235                 1240                 1245             


Asp Ile  Leu Phe Asn Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys 
    1250                 1255                 1260             


Leu Gly  Lys Glu His Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys 
    1265                 1270                 1275             


Glu Arg  Asp Ser Ala Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile 
    1280                 1285                 1290             


Lys Leu  Leu Gly Phe Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser 
    1295                 1300                 1305             


Phe Leu  Gly Ile Lys Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys 
    1310                 1315                 1320             


Asp Tyr  Leu Leu Pro Cys Met  Glu Ala Thr Leu Ile  His Gln Ser 
    1325                 1330                 1335             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Asn  Lys Leu Gly 
    1340                 1345                 1350             


Gly Asp  
    1355 


<210>  669
<211>  773
<212>  PRT
<213>  Streptococcus agalactiae 18RS21

<400>  669

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln 
    770             


<210>  670
<211>  1345
<212>  PRT
<213>  Streptococcus mutans SF14

<400>  670

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asn Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Ile Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Ala  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  671
<211>  1345
<212>  PRT
<213>  Streptococcus anginosus F0211

<400>  671

Met Asp Gln Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Gln Ser Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Asn Lys Val Asp Glu Asn 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Asp Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Ile Ala Ala Glu Val Lys Tyr 
        115                 120                 125             


His Asp Asp Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ile Ser Gln Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gln Leu Lys Ala 
                165                 170                 175     


Glu Asn Thr Asn Val Gln Ala Leu Phe Lys Asp Phe Val Glu Val Tyr 
            180                 185                 190         


Asp Lys Thr Val Glu Glu Ser His Leu Ser Glu Met Thr Val Asp Ala 
        195                 200                 205             


Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala His Tyr Pro Ala Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Gly Leu Leu Gly Glu Ile Gly Asp Glu Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Glu Glu His Gln Lys Asp Leu Lys Lys Leu Lys 
                325                 330                 335     


Asp Phe Ile Lys Val Asn Ala Pro Asp Gln Tyr Asn Ala Ile Phe Lys 
            340                 345                 350         


Asp Lys Asn Lys Lys Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Gly Ile Leu Leu Gln Ile Asn 
    370                 375                 380                 


Gly Ser Gly Asp Phe Leu Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Glu Glu His Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Gly Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr Lys Ala Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp 
465                 470                 475                 480 


Ile Leu Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr 
                485                 490                 495     


Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Asn Glu Gln Gly Glu Ala Lys Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile 
                565                 570                 575     


Val Asn Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ser Ser 
            580                 585                 590         


Leu Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Ser Phe Leu 
        595                 600                 605             


Asp Asp Lys Ala Asn Glu Lys Thr Ile Glu Asp Ile Ile Gln Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr 
625                 630                 635                 640 


Ser Asp Ile Phe Thr Lys Ala Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Asn Lys Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Tyr Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Arg Ala Gln Ile Ile Gly Asp Val Asp Asp 
705                 710                 715                 720 


Ile Ala Asn Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly His Asn Pro Ala Asn Ile Ile Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Met Thr Asp Lys Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Leu Leu 
    770                 775                 780                 


Gln Asp Ser Leu Lys Asn Leu Asp Asn Pro Val Asn Ile Lys Asn Val 
785                 790                 795                 800 


Glu Asn Gln Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Ile Gln 
                805                 810                 815     


Asn Gly Lys Asp Met Tyr Thr Gly Glu Thr Leu Asp Ile Asn Asn Leu 
            820                 825                 830         


Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys Asp 
        835                 840                 845             


Asn Ser Leu Asp Asn Arg Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asp Val Pro Ser Ile Glu Val Val His Glu Met Lys Ser 
865                 870                 875                 880 


Phe Trp Ser Lys Leu Leu Ser Val Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Glu Glu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Glu Arg Phe Asn Thr Glu Phe Asp Gly 
    930                 935                 940                 


Asn Lys Arg Arg Ile Arg Asn Val Lys Ile Ile Thr Leu Lys Ser Asn 
945                 950                 955                 960 


Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Asn Ala Leu Leu Leu Lys Tyr  Pro Gln Leu Glu Pro  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Glu Tyr Pro Lys Tyr  Asn Ser Tyr Arg Ser  Arg Lys Ser 
    1010                 1015                 1020             


Ala Thr  Glu Lys Phe Leu Phe  Tyr Ser Asn Ile Leu  Arg Phe Phe 
    1025                 1030                 1035             


Lys Lys  Glu Asp Ile Gln Thr  Asn Glu Asp Gly Glu  Ile Ala Trp 
    1040                 1045                 1050             


Asn Lys  Glu Lys His Ile Lys  Ile Leu Arg Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Glu Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Asn  Ser Tyr Trp Asn Pro  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Val  Val Ala Tyr Ser Ile  Leu Val Phe 
    1115                 1120                 1125             


Ala Asp  Val Glu Lys Gly Lys  Ser Lys Lys Leu Arg  Lys Val Gln 
    1130                 1135                 1140             


Asp Met  Val Gly Ile Thr Ile  Met Glu Lys Lys Arg  Phe Glu Lys 
    1145                 1150                 1155             


His Pro  Val Asp Phe Leu Glu  Gln Arg Gly Tyr Arg  Asn Val Arg 
    1160                 1165                 1170             


Leu Glu  Lys Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1175                 1180                 1185             


Glu Asn  Lys Arg Arg Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Leu Val Ile  Pro Gln Arg Phe Thr  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ser Tyr Gln Ile Glu  Lys Asn Tyr Glu Pro  Glu His Arg 
    1220                 1225                 1230             


Glu Tyr  Val Glu Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Glu 
    1235                 1240                 1245             


Tyr Ile  Ser Val Phe Ser Arg  Lys Tyr Val Leu Ala  Asp Asn Asn 
    1250                 1255                 1260             


Leu Thr  Lys Ile Glu Met Leu  Phe Ser Lys Asn Lys  Asp Ala Glu 
    1265                 1270                 1275             


Val Ser  Ser Leu Ala Lys Ser  Phe Ile Ser Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Phe  Gly Ala Pro Ala Ala  Phe Asn Phe Phe Gly  Glu Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Val Thr Glu Cys Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Glu Asp  
    1340                 1345 


<210>  672
<211>  1338
<212>  PRT
<213>  Streptococcus macacae NCTC 11558

<400>  672

Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Gly Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Lys Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ala Lys Ala Asp Glu Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Asn Glu Ser Phe Leu Thr Asn Asp Asp Lys Glu 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Glu Ala His 
        115                 120                 125             


His His Lys Phe Pro Thr Ile Phe His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ser Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gln Leu Lys Ala 
                165                 170                 175     


Glu Asn Thr Asn Val Gln Thr Leu Phe Asp Asp Phe Val Glu Val Tyr 
            180                 185                 190         


Asp Lys Thr Val Glu Glu Ser His Leu Ser Glu Ile Ser Val Ser Ser 
        195                 200                 205             


Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
    210                 215                 220                 


Lys Tyr Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn Leu Ile 
225                 230                 235                 240 


Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe Lys Leu 
                245                 250                 255     


Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu Glu Asp 
            260                 265                 270         


Leu Gly Glu Leu Leu Gly Lys Ile Gly Asp Asn Tyr Ala Asp Leu Phe 
        275                 280                 285             


Ile Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly Ile Leu 
    290                 295                 300                 


Thr Ile Asp Asp Asn Thr Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
305                 310                 315                 320 


Lys Arg Tyr Glu Glu His Gln Glu Asp Leu Ala Gln Leu Lys Lys Phe 
                325                 330                 335     


Ile Arg Gln Asn Leu Pro Asp Gln Tyr Ser Glu Val Phe Ser Asp Lys 
            340                 345                 350         


Thr Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn Gln Glu 
        355                 360                 365             


Ala Phe Tyr Lys Tyr Ile Lys Asn Met Leu Ser Lys Thr Glu Gly Ala 
    370                 375                 380                 


Asp Tyr Phe Leu Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg Lys Gln 
385                 390                 395                 400 


Arg Thr Phe Asp Asn Gly Ser Val Pro His Gln Ile His Leu Gln Glu 
                405                 410                 415     


Met His Ala Ile Leu Arg Arg Gln Gly Glu Tyr Tyr Pro Phe Leu Lys 
            420                 425                 430         


Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
        435                 440                 445             


Tyr Val Gly Pro Leu Ala Arg Lys Gly Ser Arg Phe Ala Trp Ala Glu 
    450                 455                 460                 


Tyr Lys Ala Asp Lys Lys Val Thr Pro Trp Asn Phe Asp Asp Ile Leu 
465                 470                 475                 480 


Asp Lys Glu Lys Ser Ala Glu Glu Phe Ile Thr Arg Met Thr Leu Asn 
                485                 490                 495     


Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser Leu Val 
            500                 505                 510         


Tyr Glu Thr Phe Asn Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
        515                 520                 525             


Asn Glu Gln Gly Lys Ala Ile Phe Phe Asp Ala Asn Met Lys Gln Glu 
    530                 535                 540                 


Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys Asp Lys 
545                 550                 555                 560 


Leu Leu Asn Tyr Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile Val Asn 
                565                 570                 575     


Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ser Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Ser Phe Leu Asp Asp 
        595                 600                 605             


Lys Val Asn Glu Lys Ile Ile Glu Asp Ile Ile Gln Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr Ser Asp 
625                 630                 635                 640 


Ile Phe Thr Thr Gln Gln Leu Lys Lys Leu Glu Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Asn Lys Thr Ile Leu Gly Tyr Leu Ile Asp Asp Gly Tyr Ser 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Pro Phe Lys 
    690                 695                 700                 


Glu Glu Ile Ala Arg Ala Gln Val Ile Gly Glu Thr Asp Asp Leu Asn 
705                 710                 715                 720 


Gln Leu Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly His 
            740                 745                 750         


Asn Pro Ala Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Arg Arg Ser Ser Gln Gln Arg Tyr Lys Arg Leu Glu Glu 
    770                 775                 780                 


Ala Ile Lys Asn Leu Asp His Asp Leu Asn His Lys Ile Leu Lys Glu 
785                 790                 795                 800 


His Pro Thr Asp Asn Gln Ala Leu Gln Asn Asp Arg Leu Phe Leu Tyr 
                805                 810                 815     


Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Glu Asp Pro Leu Asp Ile 
            820                 825                 830         


Asn Arg Leu Ser Asp Tyr Asp Ile Asp His Ile Ile Pro Gln Ser Phe 
        835                 840                 845             


Ile Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Val Ser Ser Ala Lys 
    850                 855                 860                 


Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Asp Val Val Asn Arg 
865                 870                 875                 880 


Met Arg Pro Phe Trp Asn Lys Leu Leu Ser Cys Gly Leu Ile Ser Gln 
                885                 890                 895     


Arg Lys Tyr Ser Asn Leu Thr Lys Lys Glu Leu Lys Pro Asp Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ala Arg Phe Asn Thr Lys Arg Asp Glu 
    930                 935                 940                 


Asn Lys Lys Val Ile Arg Asp Val Lys Ile Ile Thr Leu Lys Ser Asn 
945                 950                 955                 960 


Leu Val Ser Gln Phe Arg Lys Asp Phe Lys Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Ile 
            980                 985                 990         


Gly Lys Ala Leu Leu Asp Val Tyr  Pro Gln Leu Glu Pro  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Glu Tyr Pro His Phe  His Gly Tyr Lys Glu  Asn Lys Ala 
    1010                 1015                 1020             


Thr Ala  Lys Lys Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1025                 1030                 1035             


Lys Asp  Asp Ile Arg Thr Asp  Glu Asn Gly Glu Ile  Val Trp Lys 
    1040                 1045                 1050             


Lys Asp  Glu His Ile Ser Asn  Ile Lys Arg Val Leu  Ser Tyr Pro 
    1055                 1060                 1065             


Gln Val  Asn Ile Val Lys Lys  Val Glu Ile Gln Thr  Val Gly Gln 
    1070                 1075                 1080             


Asn Gly  Gly Leu Phe Asp Asp  Asn Pro Lys Ser Pro  Leu Glu Val 
    1085                 1090                 1095             


Thr Pro  Ser Lys Leu Val Pro  Leu Lys Lys Glu Leu  Asn Pro Lys 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Tyr Gln Lys  Pro Thr Thr Ala Tyr  Pro Val Leu 
    1115                 1120                 1125             


Leu Ile  Thr Asp Thr Lys Gln  Leu Ile Pro Ile Ser  Val Met Asn 
    1130                 1135                 1140             


Lys Lys  Gln Phe Glu Gln Asn  Pro Val Lys Phe Leu  Arg Asp Arg 
    1145                 1150                 1155             


Gly Tyr  Gln Gln Val Gly Lys  Asn Asp Phe Ile Lys  Leu Pro Lys 
    1160                 1165                 1170             


Tyr Thr  Leu Val Asp Ile Gly  Asp Gly Ile Lys Arg  Leu Trp Ala 
    1175                 1180                 1185             


Ser Ser  Lys Glu Ile His Lys  Gly Asn Gln Leu Val  Val Ser Lys 
    1190                 1195                 1200             


Lys Ser  Gln Ile Leu Leu Tyr  His Ala His His Leu  Asp Ser Asp 
    1205                 1210                 1215             


Leu Ser  Asn Asp Tyr Leu Gln  Asn His Asn Gln Gln  Phe Asp Val 
    1220                 1225                 1230             


Leu Phe  Asn Glu Ile Ile Ser  Phe Ser Lys Lys Cys  Lys Leu Gly 
    1235                 1240                 1245             


Lys Glu  His Ile Gln Lys Ile  Glu Asn Val Tyr Ser  Asn Lys Lys 
    1250                 1255                 1260             


Asn Ser  Ala Ser Ile Glu Glu  Leu Ala Glu Ser Phe  Ile Lys Leu 
    1265                 1270                 1275             


Leu Gly  Phe Thr Gln Leu Gly  Ala Thr Ser Pro Phe  Asn Phe Leu 
    1280                 1285                 1290             


Gly Val  Lys Leu Asn Gln Lys  Gln Tyr Lys Gly Lys  Lys Asp Tyr 
    1295                 1300                 1305             


Ile Leu  Pro Cys Thr Glu Gly  Thr Leu Ile Arg Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Thr Arg Val  Asp Leu Ser Lys Ile  Gly Glu Asp 
    1325                 1330                 1335             


<210>  673
<211>  1371
<212>  PRT
<213>  Streptococcus sp. F0441

<400>  673

Met Glu Asn Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ser Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys His Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Ala Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ser Glu Glu Ile Gly Lys Val Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Ile Pro Glu Asp Lys 
            100                 105                 110         


Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Ala Glu Glu Lys Lys 
        115                 120                 125             


Tyr His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ala Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asn Asn Thr Phe Glu Gly Asn Ser Leu Ser Gly Gln Asn Val Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 
    210                 215                 220                 


Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Arg Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asn Pro Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Ser Leu 
                325                 330                 335     


Lys Gln Phe Ile Lys Asn Asn Leu Pro Glu Lys Tyr Asp Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Glu Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Thr Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Glu Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Asp Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly 
    530                 535                 540                 


Gln Lys Lys Gln Ile Val Thr Gln Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Gln Phe Leu His Asn Val Asp Gly Tyr Asp 
                565                 570                 575     


Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Ala Phe Met Asp 
        595                 600                 605             


Asp Ala Lys Asn Glu Ala Ile Leu Glu Asn Ile Val His Thr Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asp 
625                 630                 635                 640 


Ser Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Ser Asp 
            660                 665                 670         


Lys Gln Thr Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Glu 
        675                 680                 685             


Ile Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe 
    690                 695                 700                 


Lys Glu Ile Ile Gln Lys Ala Gln Val Val Gly Lys Thr Asn Asp Val 
705                 710                 715                 720 


Lys Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Ala Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu 
    770                 775                 780                 


Asp Ser Leu Lys Ile Leu Ala Ser Gly Leu Asn Ser Lys Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Glu Ala Leu Asp 
            820                 825                 830         


Ile Asn Gln Leu Ser Ser Cys Asp Ile Asp His Ile Ile Pro Gln Ala 
        835                 840                 845             


Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys 
    850                 855                 860                 


Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val Val Asp 
865                 870                 875                 880 


Lys Met Lys Val Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser 
                885                 890                 895     


Tyr Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asn 
            900                 905                 910         


Glu Leu Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala Arg Phe Asn Lys 
    930                 935                 940                 


Glu Val Thr Glu Lys Asp Lys Lys Asn Arg Thr Val Lys Ile Ile Thr 
945                 950                 955                 960 


Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Ala Val Val Ala Lys Ala Ile  Leu Lys Lys Tyr Pro  Lys Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Asp  Tyr Gln Lys Tyr Asp  Leu Lys Arg 
    1010                 1015                 1020             


Tyr Ile  Ser Arg Ser Lys Asp  Pro Lys Glu Ile Glu  Lys Ala Thr 
    1025                 1030                 1035             


Glu Lys  Tyr Phe Phe Tyr Ser  Asn Leu Leu Asn Phe  Phe Lys Glu 
    1040                 1045                 1050             


Glu Val  His Tyr Ala Asp Gly  Thr Ile Val Lys Arg  Glu Asn Ile 
    1055                 1060                 1065             


Glu Tyr  Ser Lys Asp Thr Gly  Glu Ile Ala Trp Asn  Lys Glu Lys 
    1070                 1075                 1080             


Asp Phe  Ala Thr Ile Lys Lys  Val Leu Ser Leu Pro  Gln Val Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Arg Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1100                 1105                 1110             


Ser Ile  Leu Pro Lys Gly Asn  Ser Asp Lys Leu Ile  Pro Arg Lys 
    1115                 1120                 1125             


Thr Lys  Asp Ile Leu Trp Asp  Thr Thr Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Val Ile Ala Tyr Ser  Ile Leu Leu Ile Ala  Asp Ile Glu 
    1145                 1150                 1155             


Lys Gly  Lys Ala Lys Lys Leu  Lys Thr Val Lys Thr  Leu Val Gly 
    1160                 1165                 1170             


Ile Thr  Ile Met Glu Lys Asp  Ala Phe Glu Lys Asn  Pro Ile Ala 
    1175                 1180                 1185             


Phe Leu  Glu Asn Lys Gly Tyr  His Asn Val Cys Lys  Glu Asn Ile 
    1190                 1195                 1200             


Leu Cys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1205                 1210                 1215             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Leu Gln Lys  Cys Asn Glu 
    1220                 1225                 1230             


Ile Val  Leu Pro Val Tyr Leu  Thr Thr Leu Leu Tyr  His Ser Lys 
    1235                 1240                 1245             


Asn Val  His Lys Leu Asp Glu  Pro Gly His Leu Glu  Tyr Ile Gln 
    1250                 1255                 1260             


Lys His  Arg Asn Glu Phe Lys  Asp Leu Leu Asn Leu  Val Ser Glu 
    1265                 1270                 1275             


Phe Ser  Gln Lys Tyr Val Leu  Ala Asp Ala Asn Leu  Glu Lys Ile 
    1280                 1285                 1290             


Lys Asn  Leu Tyr Ala Asp Asn  Glu Gln Ala Asp Ile  Glu Ile Leu 
    1295                 1300                 1305             


Ala Asn  Ser Phe Ile Asn Leu  Leu Thr Phe Thr Ala  Leu Gly Ala 
    1310                 1315                 1320             


Pro Ala  Ala Phe Lys Phe Phe  Gly Lys Asp Val Asp  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Thr  Thr Val Ser Glu Ile  Leu Asn Ala Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu 
    1355                 1360                 1365             


Gly Glu  Asp 
    1370     


<210>  674
<211>  1345
<212>  PRT
<213>  Streptococcus mutans M230

<400>  674

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Gln Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  675
<211>  1367
<212>  PRT
<213>  Streptococcus pyogenes MGAS15252

<400>  675

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Gly Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Ile Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Ala Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Gly Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  676
<211>  1350
<212>  PRT
<213>  Streptococcus mutans NFSM1

<400>  676

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Thr Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Thr Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val Val Asn Arg Met Arg 
865                 870                 875                 880 


Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu Ile Ser Gln Arg Lys 
                885                 890                 895     


Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Pro Asp Asp Lys Ala Gly 
            900                 905                 910         


Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val 
        915                 920                 925             


Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu Phe Asp Asp Asn Asn 
    930                 935                 940                 


Lys Arg Ile Arg Arg Val Lys Ile Val Thr Leu Lys Ser Asn Leu Val 
945                 950                 955                 960 


Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn 
                965                 970                 975     


Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Val Lys 
            980                 985                 990         


Ala Leu Leu Val Lys Tyr Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly 
        995                 1000                 1005             


Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu Arg Lys  Thr Ala Thr 
    1010                 1015                 1020             


Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met Asn Met  Phe Lys Ser 
    1025                 1030                 1035             


Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val Glu Arg  Pro Met Ile 
    1040                 1045                 1050             


Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala Trp Asp  Lys Thr Lys 
    1055                 1060                 1065             


His Ile  Thr Thr Val Lys Lys  Val Leu Ser Tyr Pro  Gln Val Asn 
    1070                 1075                 1080             


Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile Gly Gln  Asn Gly Gly 
    1085                 1090                 1095             


Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu Glu Val  Ile Pro Ser 
    1100                 1105                 1110             


Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn Pro Glu  Lys Tyr Gly 
    1115                 1120                 1125             


Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro Ile Leu  Leu Ile Val 
    1130                 1135                 1140             


Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val Met Asp  Lys Lys Arg 
    1145                 1150                 1155             


Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys Asp Lys  Gly Tyr Gln 
    1160                 1165                 1170             


Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu Pro Lys  Tyr Thr Leu 
    1175                 1180                 1185             


Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu Trp Ala  Ser Ser Lys 
    1190                 1195                 1200             


Glu Val  His Lys Gly Asn Gln  Leu Val Val Ser Lys  Lys Ser Gln 
    1205                 1210                 1215             


Asp Leu  Leu Tyr His Ala His  His Leu Asp Asn Asp  Tyr Ser Asn 
    1220                 1225                 1230             


Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe Asp Ile  Leu Phe Asn 
    1235                 1240                 1245             


Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys Leu Gly  Lys Glu His 
    1250                 1255                 1260             


Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys Glu Arg  Asp Ser Ala 
    1265                 1270                 1275             


Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile Lys Leu  Leu Gly Phe 
    1280                 1285                 1290             


Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser Phe Leu  Gly Ile Lys 
    1295                 1300                 1305             


Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys Asp Tyr  Leu Leu Pro 
    1310                 1315                 1320             


Cys Met  Glu Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1325                 1330                 1335             


Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345                 1350 


<210>  677
<211>  1388
<212>  PRT
<213>  Streptococcus thermophilus (strain ND03)

<400>  677

Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asn Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Ser Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Val Leu Leu Phe Asp Ser Gly Ile Thr Ala Glu Gly Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Thr Glu Met Ala Thr Leu Asp Asp Ala 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Pro Asp Asp Lys Arg 
            100                 105                 110         


Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val Glu Glu Lys Ala Tyr 
        115                 120                 125             


His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Ser Thr Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Phe Asn Ser 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Asn Phe Gln Asp Phe Leu Asp Thr Tyr 
            180                 185                 190         


Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu Asn Ser Lys Gln Leu 
        195                 200                 205             


Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Leu Glu Lys Lys Asp Arg 
    210                 215                 220                 


Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser Gly Ile Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Arg Lys Cys Phe 
                245                 250                 255     


Asn Leu Asp Glu Lys Ala Ser Leu His Phe Ser Lys Glu Ser Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Thr Leu Leu Gly Tyr Ile Gly Asp Asp Tyr Ser Asp 
        275                 280                 285             


Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Phe Leu Thr Val Thr Asp Asn Glu Thr Glu Ala Pro Leu Ser Ser Ala 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asn Glu His Lys Glu Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Glu Tyr Ile Arg Asn Ile Ser Leu Lys Thr Tyr Asn Glu Val Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Asp Phe Tyr Val Tyr Leu Lys Asn Leu Leu Ala Glu Phe Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Leu Asp Lys Gln Ala Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala Trp 
    450                 455                 460                 


Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro Trp Asn Phe Glu Asp 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu Leu Thr Lys Val Arg 
        515                 520                 525             


Phe Ile Ala Glu Ser Met Arg Asp Tyr Gln Phe Leu Asp Ser Lys Gln 
    530                 535                 540                 


Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp Lys Arg Lys Val Thr 
545                 550                 555                 560 


Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile Tyr Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ser Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys Glu Phe Leu Asp Asp 
        595                 600                 605             


Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ser Lys Phe Glu Asn 
625                 630                 635                 640 


Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Glu 
            660                 665                 670         


Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ile Ser 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ala Leu Ser Phe Lys 
    690                 695                 700                 


Lys Lys Ile Gln Lys Ala Gln Ile Ile Gly Asp Glu Asp Lys Gly Asn 
705                 710                 715                 720 


Ile Lys Glu Val Val Lys Ser Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly Gly Arg Lys Pro Glu Ser Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Tyr Thr Asn Gln Gly Lys Ser Asn Ser Gln Gln Arg Leu Lys Arg 
    770                 775                 780                 


Leu Glu Lys Ser Leu Lys Glu Leu Gly Ser Lys Ile Leu Lys Glu Asn 
785                 790                 795                 800 


Ile Pro Ala Lys Leu Ser Lys Ile Asp Asn Asn Ala Leu Gln Asn Asp 
                805                 810                 815     


Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly 
            820                 825                 830         


Asp Asp Leu Asp Ile Asp Arg Leu Ser Asn Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Gln Ala Phe Leu Lys Asp Asn Ser Ile Asp Asn Lys Val Leu 
    850                 855                 860                 


Val Ser Ser Ala Ser Asn Arg Gly Lys Ser Asp Asp Phe Pro Ser Leu 
865                 870                 875                 880 


Glu Val Val Lys Lys Arg Lys Thr Phe Trp Tyr Gln Leu Leu Lys Ser 
                885                 890                 895     


Lys Leu Ile Ser Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Leu Pro Glu Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Leu Leu Asp Glu 
    930                 935                 940                 


Lys Phe Asn Asn Lys Lys Asp Glu Asn Asn Arg Ala Val Arg Thr Val 
945                 950                 955                 960 


Lys Ile Ile Thr Leu Lys Ser Thr Leu Val Ser Gln Phe Arg Lys Asp 
                965                 970                 975     


Phe Glu Leu Tyr Lys Val Cys Glu Ile Asn Asp Phe His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Ile  Ala Ser Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly Asp Tyr  Pro Lys Tyr 
    1010                 1015                 1020             


Asn Ser  Phe Arg Glu Arg Lys  Ser Ala Thr Glu Lys  Val Tyr Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Ile  Phe Lys Lys Ser Ile  Ser Leu Ala 
    1040                 1045                 1050             


Asp Gly  Arg Val Ile Glu Arg  Pro Leu Ile Glu Val  Asn Glu Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ser Val Trp Asn  Lys Glu Ser Asp Leu  Ala Thr Val 
    1070                 1075                 1080             


Arg Arg  Val Leu Ser Tyr Pro  Gln Val Asn Val Val  Lys Lys Val 
    1085                 1090                 1095             


Glu Glu  Gln Asn His Gly Leu  Asp Arg Gly Lys Pro  Lys Gly Leu 
    1100                 1105                 1110             


Phe Asn  Ala Asn Leu Ser Ser  Lys Pro Lys Pro Asn  Ser Asn Glu 
    1115                 1120                 1125             


Asn Leu  Val Gly Ala Lys Glu  Tyr Leu Asp Pro Lys  Lys Tyr Gly 
    1130                 1135                 1140             


Gly Tyr  Ala Gly Ile Ser Asn  Ser Phe Ala Val Leu  Val Lys Gly 
    1145                 1150                 1155             


Thr Ile  Glu Lys Gly Ala Lys  Lys Lys Ile Thr Asn  Val Leu Glu 
    1160                 1165                 1170             


Phe Gln  Gly Ile Ser Ile Leu  Asp Arg Ile Asn Tyr  Arg Lys Asp 
    1175                 1180                 1185             


Lys Leu  Asn Phe Leu Leu Glu  Lys Gly Tyr Lys Asp  Ile Glu Leu 
    1190                 1195                 1200             


Ile Ile  Glu Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Ser Asp Gly 
    1205                 1210                 1215             


Ser Arg  Arg Met Leu Ala Ser  Ile Leu Ser Thr Asn  Asn Lys Arg 
    1220                 1225                 1230             


Gly Glu  Ile His Lys Gly Asn  Gln Ile Phe Leu Ser  Gln Lys Phe 
    1235                 1240                 1245             


Val Lys  Leu Leu Tyr His Ala  Lys Arg Ile Ser Asn  Thr Ile Asn 
    1250                 1255                 1260             


Glu Asn  His Arg Lys Tyr Val  Glu Asn His Lys Lys  Glu Phe Glu 
    1265                 1270                 1275             


Glu Leu  Phe Tyr Tyr Ile Leu  Glu Phe Asn Glu Asn  Tyr Val Gly 
    1280                 1285                 1290             


Ala Lys  Lys Asn Gly Lys Leu  Leu Asn Ser Ala Phe  Gln Ser Trp 
    1295                 1300                 1305             


Gln Asn  His Ser Ile Asp Glu  Leu Cys Ser Ser Phe  Ile Gly Pro 
    1310                 1315                 1320             


Thr Gly  Ser Glu Arg Lys Gly  Leu Phe Glu Leu Thr  Ser Arg Gly 
    1325                 1330                 1335             


Ser Ala  Ala Asp Phe Glu Phe  Leu Gly Val Lys Ile  Pro Arg Tyr 
    1340                 1345                 1350             


Arg Asp  Tyr Thr Pro Ser Ser  Leu Leu Lys Asp Ala  Thr Leu Ile 
    1355                 1360                 1365             


His Gln  Ser Val Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ala 
    1370                 1375                 1380             


Lys Leu  Gly Glu Gly 
    1385             


<210>  678
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes serotype M12 (strain MGAS2096)

<400>  678

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Ile Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Leu Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Leu Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Thr Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Phe Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  679
<211>  1345
<212>  PRT
<213>  Streptococcus mutans serotype c (strain NN2025)

<400>  679

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Lys His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  680
<211>  1371
<212>  PRT
<213>  Streptococcus dysgalactiae subsp. equisimilis (strain GGS_124)

<400>  680

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Ser Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Met Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Glu Phe Leu Ser Gly Lys Gln 
    530                 535                 540                 


Lys Glu Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Lys Tyr Ala 
625                 630                 635                 640 


Asn Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Ala Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Ile Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Thr Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Glu Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Ala Leu Thr  Asn Glu Ser Ile Tyr  Ala Arg Gly 
    1100                 1105                 1110             


Ser Phe  Asp Lys Leu Ile Ser  Arg Lys His Arg Phe  Glu Ser Ser 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Gly Ser  Pro Thr Val Thr Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Ser Lys Val  Gln Asp Gly Lys Val  Lys Lys Ile 
    1145                 1150                 1155             


Lys Thr  Gly Lys Glu Leu Ile  Gly Met Thr Leu Leu  Asp Lys Leu 
    1160                 1165                 1170             


Val Phe  Glu Lys Asn Pro Leu  Lys Phe Ile Glu Asp  Lys Gly Tyr 
    1175                 1180                 1185             


Gly Asn  Val Gln Ile Asp Lys  Cys Ile Lys Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Phe Glu Asn Gly  Thr Arg Arg Met Leu  Ala Ser Val 
    1205                 1210                 1215             


Met Ala  Asn Asn Asn Ser Arg  Gly Asp Leu Gln Lys  Ala Asn Glu 
    1220                 1225                 1230             


Met Phe  Leu Pro Ala Lys Leu  Val Thr Leu Leu Tyr  His Ala His 
    1235                 1240                 1245             


Lys Ile  Glu Ser Ser Lys Glu  Leu Glu His Glu Ala  Tyr Ile Leu 
    1250                 1255                 1260             


Asp His  Tyr Asn Asp Leu Tyr  Gln Leu Leu Ser Tyr  Ile Glu Arg 
    1265                 1270                 1275             


Phe Ala  Ser Leu Tyr Val Asp  Val Glu Lys Asn Ile  Ser Lys Val 
    1280                 1285                 1290             


Lys Glu  Leu Phe Ser Asn Ile  Glu Ser Tyr Ser Ile  Ser Glu Ile 
    1295                 1300                 1305             


Cys Ser  Ser Val Ile Asn Leu  Leu Thr Leu Thr Ala  Ser Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Lys Phe Leu  Gly Thr Thr Ile Pro  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Gly  Ser Pro Gln Ser Ile  Leu Ser Ser Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1355                 1360                 1365             


Gly Gly  Asp 
    1370     


<210>  681
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)

<400>  681

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  682
<211>  1371
<212>  PRT
<213>  Streptococcus gallolyticus (strain ATCC 43143 / F-1867)

<400>  682

Met Thr Glu Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Lys Tyr Ile Lys Lys Asn Leu 
        35                  40                  45              


Leu Gly Ala Leu Leu Phe Asp Asn Gly Glu Thr Ala Glu Ala Thr Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ala Lys Val Asp Glu 
                85                  90                  95      


Ser Phe Phe Tyr Arg Leu Asp Glu Ser Phe Leu Thr Thr Asp Asp Lys 
            100                 105                 110         


Asp Phe Glu Arg His Pro Ile Phe Gly Asn Lys Ala Asp Glu Ile Lys 
        115                 120                 125             


Tyr His Gln Glu Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala 
    130                 135                 140                 


Asp Ser His Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn 
                165                 170                 175     


Ala Glu Asn Thr Asp Val Gln Lys Leu Phe Glu Ala Phe Val Glu Val 
            180                 185                 190         


Tyr Asp Arg Thr Phe Asp Asp Ser Asn Leu Ser Glu Ile Thr Val Asp 
        195                 200                 205             


Ala Ser Ser Ile Leu Thr Glu Lys Phe Ser Lys Ser Arg Arg Leu Glu 
    210                 215                 220                 


Asn Leu Ile Lys His Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly 
225                 230                 235                 240 


Asn Leu Val Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Thr Ser 
                245                 250                 255     


Phe Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Glu Glu Asp Leu Glu Glu Leu Ile Gly Lys Ile Gly Asp Glu Tyr Ala 
        275                 280                 285             


Asp Leu Phe Thr Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ala Asp Asn Thr Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Lys Arg Tyr Asn Glu His Gln Val Asp Leu Lys Lys Leu 
                325                 330                 335     


Lys Glu Phe Ile Lys Asn Asn Ala Ser Asp Lys Tyr Asp Glu Ile Phe 
            340                 345                 350         


Asn Asp Lys Asp Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val 
        355                 360                 365             


Lys Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Thr Thr Leu Ser Lys Ile 
    370                 375                 380                 


Asp Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Ala 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Ala Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asn Ser Arg Phe Ala 
    450                 455                 460                 


Trp Ala Glu Tyr His Ser Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp 
465                 470                 475                 480 


Glu Ile Ile Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met 
                485                 490                 495     


Thr Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Val Tyr Glu Thr Tyr Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Tyr Val Asn Glu Gln Gly Lys Ser Asn Phe Phe Asp Ala Asn Met 
    530                 535                 540                 


Lys Gln Glu Ile Phe Glu His Val Phe Lys Glu Asn Arg Lys Val Thr 
545                 550                 555                 560 


Lys Asp Lys Phe Leu Asn Tyr Leu Asn Lys Glu Phe Pro Glu Tyr Arg 
                565                 570                 575     


Ile Gln Asp Leu Ile Gly Leu Asp Lys Glu Asn Lys Ser Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Ser Phe 
        595                 600                 605             


Leu Asp Asp Lys Thr Asn Glu Thr Ile Ile Glu Asp Ile Ile Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Asp Met Ile Arg Gln Arg Leu Gln Lys 
625                 630                 635                 640 


Tyr Ser Asp Ile Phe Thr Pro Gln Gln Leu Lys Lys Leu Glu Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asn Lys Glu Asn Gly Lys Ser Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Tyr Ala Asn Arg Asn Phe Met Gln Leu Ile Ser Asp Asp Thr Leu 
    690                 695                 700                 


Pro Phe Lys Gln Ile Ile Lys Asp Ala Gln Ile Ile Gly Asp Ile Asp 
705                 710                 715                 720 


Asp Val Thr Ser Val Val Arg Glu Leu Pro Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly His Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Arg Gly Arg Asn Gln Ser Gln Gln Arg Leu Lys Lys 
    770                 775                 780                 


Leu Gln Asp Ser Leu Lys Glu Leu Gly Ser Asn Ile Leu Asn Glu Glu 
785                 790                 795                 800 


Lys Pro Ser Tyr Ile Glu Gly Lys Val Glu Asn Asn His Leu Gln Asp 
                805                 810                 815     


Asp Arg Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met Tyr Thr 
            820                 825                 830         


Gly Asp Glu Leu Asp Ile Asp His Leu Ser Asp Tyr Asp Ile Asp His 
        835                 840                 845             


Ile Ile Pro Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val 
    850                 855                 860                 


Leu Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser 
865                 870                 875                 880 


Leu Asp Ile Val His Asp Arg Lys Ala Asp Trp Ile Arg Leu Tyr Lys 
                885                 890                 895     


Ser Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu 
            900                 905                 910         


Arg Gly Gly Leu Thr Glu Asn Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp 
    930                 935                 940                 


Ser Arg Phe Asn Thr Glu Arg Asp Glu Asn Asp Lys Val Ile Arg Asn 
945                 950                 955                 960 


Val Lys Val Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe Arg Lys 
                965                 970                 975     


Asp Phe Lys Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Lys Leu Ala Pro Glu  Phe Val Tyr Gly Glu  Tyr Lys Lys 
    1010                 1015                 1020             


Tyr Asp  Ile Arg Lys Phe Ile  Thr Ser Ser Gly Asp  Lys Ala Thr 
    1025                 1030                 1035             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Leu Met Asn Phe  Phe Lys Arg 
    1040                 1045                 1050             


Val Ile  Arg Tyr Ser Asn Gly  Lys Val Val Val Arg  Pro Val Ile 
    1055                 1060                 1065             


Glu Cys  Ser Lys Asp Thr Gly  Glu Ile Ala Trp Asn  Lys Gln Thr 
    1070                 1075                 1080             


Asp Phe  Glu Lys Val Arg Arg  Val Leu Ser Tyr Pro  Gln Val Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Val Glu Thr  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1100                 1105                 1110             


Ser Ile  Leu Pro Lys Gly Asn  Ser Asp Lys Leu Ile  Pro Arg Lys 
    1115                 1120                 1125             


Thr Lys  Lys Phe Arg Trp Asp  Thr Pro Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Asn Ile Ala Tyr Ser  Val Phe Val Ile Ala  Asp Val Glu 
    1145                 1150                 1155             


Lys Gly  Lys Ala Lys Lys Leu  Lys Thr Val Lys Glu  Leu Val Gly 
    1160                 1165                 1170             


Ile Ser  Ile Met Glu Arg Ser  Ser Phe Glu Glu Asn  Pro Val Val 
    1175                 1180                 1185             


Phe Leu  Glu Lys Lys Gly Tyr  Gln Asn Val Gln Glu  Asp Asn Leu 
    1190                 1195                 1200             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Phe Glu  Gly Gly Arg 
    1205                 1210                 1215             


Arg Arg  Leu Leu Ala Ser Ala  Ser Glu Leu Gln Lys  Gly Asn Glu 
    1220                 1225                 1230             


Val Val  Leu Ser Arg His Leu  Val Glu Leu Leu Tyr  His Ala His 
    1235                 1240                 1245             


Arg Val  Asn Ser Phe Asn Asn  Ser Glu His Leu Lys  Tyr Val Ser 
    1250                 1255                 1260             


Glu His  Lys Lys Glu Phe Gly  Glu Val Leu Ser Cys  Val Glu Asn 
    1265                 1270                 1275             


Phe Ala  Lys Ser Tyr Val Asp  Val Glu Lys Asn Leu  Gly Lys Ile 
    1280                 1285                 1290             


Arg Ala  Val Ala Asp Lys Ile  Asp Thr Phe Ser Ile  Glu Asp Ile 
    1295                 1300                 1305             


Ser Ile  Ser Phe Val Asn Leu  Leu Thr Leu Thr Ala  Leu Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Asn Phe Leu  Gly Glu Lys Ile Pro  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Thr  Ser Thr Lys Glu Cys  Leu Asn Ala Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu 
    1355                 1360                 1365             


Gly Glu  Glu 
    1370     


<210>  683
<211>  1371
<212>  PRT
<213>  Streptococcus gallolyticus (strain UCN34)

<400>  683

Met Thr Glu Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Lys Tyr Ile Lys Lys Asn Leu 
        35                  40                  45              


Leu Gly Ala Leu Leu Phe Asp Asn Gly Glu Thr Ala Glu Ala Thr Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ala Lys Val Asp Glu 
                85                  90                  95      


Ser Phe Phe Tyr Arg Leu Asp Glu Ser Phe Leu Thr Thr Asp Asp Lys 
            100                 105                 110         


Asp Phe Glu Arg His Pro Ile Phe Gly Asn Lys Ala Asp Glu Ile Lys 
        115                 120                 125             


Tyr His Gln Glu Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala 
    130                 135                 140                 


Asp Ser His Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn 
                165                 170                 175     


Ala Glu Asn Thr Asp Val Gln Lys Leu Phe Glu Ala Phe Val Glu Val 
            180                 185                 190         


Tyr Asp Arg Thr Phe Asp Asp Ser Asn Leu Ser Glu Ile Thr Val Asp 
        195                 200                 205             


Ala Ser Ser Ile Leu Thr Glu Lys Phe Ser Lys Ser Arg Arg Leu Glu 
    210                 215                 220                 


Asn Leu Ile Lys His Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly 
225                 230                 235                 240 


Asn Leu Val Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Thr Ser 
                245                 250                 255     


Phe Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Glu Glu Asp Leu Glu Glu Leu Ile Gly Lys Ile Gly Asp Glu Tyr Ala 
        275                 280                 285             


Asp Leu Phe Thr Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ala Asp Asn Thr Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Lys Arg Tyr Asn Glu His Gln Val Asp Leu Lys Lys Leu 
                325                 330                 335     


Lys Glu Phe Ile Lys Asn Asn Ala Ser Asp Lys Tyr Asp Glu Ile Phe 
            340                 345                 350         


Asn Asp Lys Asp Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val 
        355                 360                 365             


Lys Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Thr Thr Leu Ser Lys Ile 
    370                 375                 380                 


Asp Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Ala 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Ala Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asn Ser Arg Phe Ala 
    450                 455                 460                 


Trp Ala Glu Tyr His Ser Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp 
465                 470                 475                 480 


Glu Ile Ile Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met 
                485                 490                 495     


Thr Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Val Tyr Glu Thr Tyr Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Tyr Val Asn Glu Gln Gly Lys Ser Asn Phe Phe Asp Ala Asn Met 
    530                 535                 540                 


Lys Gln Glu Ile Phe Glu His Val Phe Lys Glu Asn Arg Lys Val Thr 
545                 550                 555                 560 


Lys Asp Lys Phe Leu Asn Tyr Leu Asn Lys Glu Phe Pro Glu Tyr Arg 
                565                 570                 575     


Ile Gln Asp Leu Ile Gly Leu Asp Lys Glu Asn Lys Ser Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Ser Phe 
        595                 600                 605             


Leu Asp Asp Lys Thr Asn Glu Thr Ile Ile Glu Asp Ile Ile Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Asp Met Ile Arg Gln Arg Leu Gln Lys 
625                 630                 635                 640 


Tyr Ser Asp Ile Phe Thr Pro Gln Gln Leu Lys Lys Leu Glu Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asn Lys Glu Asn Gly Lys Ser Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Tyr Ala Asn Arg Asn Phe Met Gln Leu Ile Ser Asp Asp Thr Leu 
    690                 695                 700                 


Pro Phe Lys Gln Ile Ile Lys Asp Ala Gln Ile Ile Gly Asp Ile Asp 
705                 710                 715                 720 


Asp Val Thr Ser Val Val Arg Glu Leu Pro Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly His Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Arg Gly Arg Asn Gln Ser Gln Gln Arg Leu Lys Lys 
    770                 775                 780                 


Leu Gln Asp Ser Leu Lys Glu Leu Gly Ser Asn Ile Leu Asn Glu Glu 
785                 790                 795                 800 


Lys Pro Ser Tyr Ile Glu Gly Lys Val Glu Asn Asn His Leu Gln Asp 
                805                 810                 815     


Asp Arg Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met Tyr Thr 
            820                 825                 830         


Gly Asp Glu Leu Asp Ile Asp His Leu Ser Asp Tyr Asp Ile Asp His 
        835                 840                 845             


Ile Ile Pro Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val 
    850                 855                 860                 


Leu Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser 
865                 870                 875                 880 


Leu Asp Ile Val His Asp Arg Lys Ala Asp Trp Ile Arg Leu Tyr Lys 
                885                 890                 895     


Ser Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu 
            900                 905                 910         


Arg Gly Gly Leu Thr Glu Asn Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp 
    930                 935                 940                 


Ser Arg Phe Asn Thr Glu Arg Asp Glu Asn Asp Lys Val Ile Arg Asn 
945                 950                 955                 960 


Val Lys Val Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe Arg Lys 
                965                 970                 975     


Asp Phe Lys Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Lys Leu Ala Pro Glu  Phe Val Tyr Gly Glu  Tyr Lys Lys 
    1010                 1015                 1020             


Tyr Asp  Ile Arg Lys Phe Ile  Thr Ser Ser Gly Asp  Lys Ala Thr 
    1025                 1030                 1035             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Leu Met Asn Phe  Phe Lys Arg 
    1040                 1045                 1050             


Val Ile  Arg Tyr Ser Asn Gly  Lys Val Val Val Arg  Pro Val Ile 
    1055                 1060                 1065             


Glu Cys  Ser Lys Asp Thr Gly  Glu Ile Ala Trp Asn  Lys Gln Thr 
    1070                 1075                 1080             


Asp Phe  Glu Lys Val Arg Arg  Val Leu Ser Tyr Pro  Gln Val Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Val Glu Thr  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1100                 1105                 1110             


Ser Ile  Leu Pro Lys Gly Asn  Ser Asp Lys Leu Ile  Pro Arg Lys 
    1115                 1120                 1125             


Thr Lys  Lys Phe Arg Trp Asp  Thr Pro Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Asn Ile Ala Tyr Ser  Val Phe Val Ile Ala  Asp Val Glu 
    1145                 1150                 1155             


Lys Gly  Lys Ala Lys Lys Leu  Lys Thr Val Lys Glu  Leu Val Gly 
    1160                 1165                 1170             


Ile Ser  Ile Met Glu Arg Ser  Ser Phe Glu Glu Asn  Pro Val Val 
    1175                 1180                 1185             


Phe Leu  Glu Lys Lys Gly Tyr  Gln Asn Val Gln Glu  Asp Asn Leu 
    1190                 1195                 1200             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Phe Glu  Gly Gly Arg 
    1205                 1210                 1215             


Arg Arg  Leu Leu Ala Ser Ala  Ser Glu Leu Gln Lys  Gly Asn Glu 
    1220                 1225                 1230             


Val Val  Leu Ser Arg His Leu  Val Glu Leu Leu Tyr  His Ala His 
    1235                 1240                 1245             


Arg Val  Asn Ser Phe Asn Asn  Ser Glu His Leu Lys  Tyr Val Ser 
    1250                 1255                 1260             


Glu His  Lys Lys Glu Phe Gly  Glu Val Leu Ser Cys  Val Glu Asn 
    1265                 1270                 1275             


Phe Ala  Lys Ser Tyr Val Asp  Val Glu Lys Asn Leu  Gly Lys Ile 
    1280                 1285                 1290             


Arg Ala  Val Ala Asp Lys Ile  Asp Thr Phe Ser Ile  Glu Asp Ile 
    1295                 1300                 1305             


Ser Ile  Ser Phe Val Asn Leu  Leu Thr Leu Thr Ala  Leu Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Asn Phe Leu  Gly Glu Lys Ile Pro  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Thr  Ser Thr Lys Glu Cys  Leu Asn Ala Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu 
    1355                 1360                 1365             


Gly Glu  Glu 
    1370     


<210>  684
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae serotype Ia (strain GD201008-001)

<400>  684

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  685
<211>  1377
<212>  PRT
<213>  Streptococcus agalactiae serotype III (strain NEM316)

<400>  685

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Tyr Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Val Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His His Glu Asp Leu Lys His Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Asn Tyr Arg Glu Val Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Leu Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Arg Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Phe Leu Ala Glu Gly Phe Lys Asp Phe Gln Phe Leu Asn Arg Lys 
    530                 535                 540                 


Gln Lys Glu Thr Ile Phe Asn Ser Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Ser Phe Leu Asn Lys Val Asp Gly Tyr Glu 
                565                 570                 575     


Gly Ile Ala Ile Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Lys Lys Ile Leu Gly Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Thr Asp Asn Glu Leu Ile Leu Glu Asp Ile Val Gln Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Lys Cys Leu Asp Ile Tyr Lys Asp 
625                 630                 635                 640 


Phe Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asn Lys 
            660                 665                 670         


Glu Asn Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ser Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Asp Leu Ser Phe Lys 
    690                 695                 700                 


Pro Ile Ile Asp Lys Ala Arg Thr Gly Ser His Ser Asp Asn Leu Lys 
705                 710                 715                 720 


Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 
            740                 745                 750         


Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Leu Ser Arg Ser Arg Gln Arg Leu Thr Thr Leu Arg Glu 
    770                 775                 780                 


Ser Leu Ala Asn Leu Lys Ser Asn Ile Leu Glu Glu Lys Lys Pro Lys 
785                 790                 795                 800 


Tyr Val Lys Asp Gln Val Glu Asn His His Leu Ser Asp Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Lys Lys Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile Glu Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Met Phe Trp Lys Asn Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Val Asp Asn Gly Lys Lys Ile Cys Lys Val Lys Ile Val 
945                 950                 955                 960 


Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly Phe 
                965                 970                 975     


Tyr Lys Ile Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr 
            980                 985                 990         


Leu Asn Ala Val Val Ala Lys Ala  Ile Leu Thr Lys Tyr  Pro Gln Leu 
        995                 1000                 1005             


Glu Pro  Glu Phe Val Tyr Gly  Met Tyr Arg Gln Lys  Lys Leu Ser 
    1010                 1015                 1020             


Lys Ile  Val His Glu Asp Lys  Glu Glu Lys Tyr Ser  Glu Ala Thr 
    1025                 1030                 1035             


Arg Lys  Met Phe Phe Tyr Ser  Asn Leu Met Asn Met  Phe Lys Arg 
    1040                 1045                 1050             


Val Val  Arg Leu Ala Asp Gly  Ser Ile Val Val Arg  Pro Val Ile 
    1055                 1060                 1065             


Glu Thr  Gly Arg Tyr Met Arg  Lys Thr Ala Trp Asp  Lys Lys Lys 
    1070                 1075                 1080             


His Phe  Ala Thr Val Arg Lys  Val Leu Ser Tyr Pro  Gln Asn Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Thr Glu Ile  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1100                 1105                 1110             


Ser Ile  Leu Ala His Gly Asn  Ser Asp Lys Leu Ile  Pro Arg Lys 
    1115                 1120                 1125             


Thr Lys  Asp Ile Tyr Leu Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Ile Val Ala Tyr Ser  Val Leu Val Val Ala  Asp Ile Lys 
    1145                 1150                 1155             


Lys Gly  Lys Ala Gln Lys Leu  Lys Thr Val Thr Glu  Leu Leu Gly 
    1160                 1165                 1170             


Ile Thr  Ile Met Glu Arg Ser  Arg Phe Glu Lys Asn  Pro Ser Ala 
    1175                 1180                 1185             


Phe Leu  Glu Ser Lys Gly Tyr  Leu Asn Ile Arg Asp  Asp Lys Leu 
    1190                 1195                 1200             


Met Ile  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1205                 1210                 1215             


Arg Arg  Leu Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1220                 1225                 1230             


Leu Ala  Leu Pro Thr Gln Phe  Met Lys Phe Leu Tyr  Leu Ala Ser 
    1235                 1240                 1245             


Arg Tyr  Asn Glu Ser Lys Gly  Lys Pro Glu Glu Ile  Glu Lys Lys 
    1250                 1255                 1260             


Gln Glu  Phe Val Asn Gln His  Val Ser Tyr Phe Asp  Asp Ile Leu 
    1265                 1270                 1275             


Gln Leu  Ile Asn Asp Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1280                 1285                 1290             


Asn Leu  Glu Lys Ile Asn Lys  Leu Tyr Gln Asp Asn  Lys Glu Asn 
    1295                 1300                 1305             


Ile Pro  Val Asp Glu Leu Ala  Asn Asn Ile Ile Asn  Leu Phe Thr 
    1310                 1315                 1320             


Phe Thr  Ser Leu Gly Ala Pro  Ala Ala Phe Lys Phe  Phe Asp Lys 
    1325                 1330                 1335             


Ile Val  Asp Arg Lys Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asn 
    1340                 1345                 1350             


Ser Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1355                 1360                 1365             


Ile Asp  Leu Gly Lys Leu Gly  Glu Asp 
    1370                 1375         


<210>  686
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes serotype M3 (strain SSI-1)

<400>  686

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Leu 
            20                  25                  30          


Lys Gly Leu Gly Asn Thr Asp Arg His Gly Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Val Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Thr Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Arg Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asp Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  687
<211>  1345
<212>  PRT
<213>  Streptococcus mutans serotype c (strain ATCC 700610 / UA159)

<400>  687

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Asn  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  688
<211>  1370
<212>  PRT
<213>  Streptococcus gallolyticus (strain ATCC BAA-2069)

<400>  688

Met Thr Lys Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Lys Tyr Ile Lys Lys Asn Leu 
        35                  40                  45              


Leu Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Thr Lys Val Asp Glu 
                85                  90                  95      


Ser Phe Phe Tyr Arg Leu Asp Glu Ser Phe Leu Thr Thr Asp Glu Lys 
            100                 105                 110         


Asp Phe Glu Arg His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala 
        115                 120                 125             


Tyr His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Asn Tyr Leu Ala 
    130                 135                 140                 


Asp Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Asn 
                165                 170                 175     


Ala Glu Asn Thr Asp Val Gln Lys Leu Phe Thr Asp Phe Val Gly Val 
            180                 185                 190         


Tyr Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp 
        195                 200                 205             


Val Ala Ser Thr Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu 
    210                 215                 220                 


Asn Leu Ile Lys Tyr Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Met Asn 
                245                 250                 255     


Phe Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Glu Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala 
        275                 280                 285             


Asp Leu Phe Thr Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Lys Arg Tyr Val Glu His His Glu Asp Leu Glu Lys Leu 
                325                 330                 335     


Lys Glu Phe Ile Lys Ala Asn Lys Ser Glu Leu Tyr His Asp Ile Phe 
            340                 345                 350         


Lys Asp Lys Asn Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val 
        355                 360                 365             


Lys Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile 
    370                 375                 380                 


Asp Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Lys Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Val Arg Lys Asp Ser Arg Phe Ala 
    450                 455                 460                 


Trp Ala Glu Tyr Arg Ser Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp 
465                 470                 475                 480 


Lys Val Ile Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met 
                485                 490                 495     


Thr Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser His Val Tyr Glu Thr Tyr Ala Val Tyr Asn Glu Leu Thr Lys Ile 
        515                 520                 525             


Lys Tyr Val Asn Glu Gln Gly Lys Glu Ser Phe Phe Asp Ser Asn Met 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr 
545                 550                 555                 560 


Lys Glu Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Pro Glu Tyr Arg 
                565                 570                 575     


Ile Lys Asp Leu Ile Gly Leu Asp Lys Glu Asn Lys Ser Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Ala Phe 
        595                 600                 605             


Leu Asp Asp Lys Val Asn Glu Glu Val Ile Glu Asp Ile Ile Lys Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Lys Asp Met Ile His Glu Arg Leu Gln Lys 
625                 630                 635                 640 


Tyr Ser Asp Ile Phe Thr Ala Asn Gln Leu Lys Lys Leu Glu Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asn Lys Glu Asn Asn Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Ser Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Thr Leu 
    690                 695                 700                 


Pro Phe Lys Gln Ile Ile Gln Lys Ser Gln Val Val Gly Asp Val Asp 
705                 710                 715                 720 


Asp Ile Glu Ala Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Asp Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Arg Gly Arg Ser Gln Ser Gln Gln Arg Leu Lys Lys 
    770                 775                 780                 


Leu Gln Ser Ser Leu Lys Glu Leu Gly Ser Asn Ile Leu Asn Glu Glu 
785                 790                 795                 800 


Lys Pro Ser Tyr Ile Glu Asp Lys Val Glu Asn Ser His Leu Gln Asn 
                805                 810                 815     


Asp Gln Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met Tyr Thr 
            820                 825                 830         


Gly Asp Glu Leu Asp Ile Asp His Leu Ser Asp Tyr Asp Ile Asp His 
        835                 840                 845             


Ile Ile Pro Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val 
    850                 855                 860                 


Leu Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser 
865                 870                 875                 880 


Leu Asp Ile Val Arg Ala Arg Lys Ala Glu Trp Val Arg Leu Tyr Lys 
                885                 890                 895     


Ser Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu 
            900                 905                 910         


Arg Gly Gly Leu Thr Glu Ala Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp 
    930                 935                 940                 


Ala Arg Phe Asn Thr Glu His Asp Glu Asn Asp Lys Val Ile Arg Asp 
945                 950                 955                 960 


Val Lys Val Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe Arg Lys 
                965                 970                 975     


Asp Phe Glu Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Lys Leu Ala Ser Glu  Phe Val Tyr Gly Glu  Tyr Lys Lys 
    1010                 1015                 1020             


Tyr Asp  Ile Arg Lys Phe Ile  Thr Asn Ser Ser Asp  Lys Ala Thr 
    1025                 1030                 1035             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Leu Met Asn Phe  Phe Lys Thr 
    1040                 1045                 1050             


Lys Val  Lys Tyr Ala Asp Gly  Thr Val Phe Glu Arg  Pro Ile Ile 
    1055                 1060                 1065             


Glu Thr  Asn Ala Asp Gly Glu  Ile Ala Trp Asn Lys  Gln Ile Asp 
    1070                 1075                 1080             


Phe Glu  Lys Val Arg Lys Val  Leu Ser Tyr Pro Gln  Val Asn Ile 
    1085                 1090                 1095             


Val Lys  Lys Val Glu Thr Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1100                 1105                 1110             


Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu Ile Pro  Arg Lys Thr 
    1115                 1120                 1125             


Lys Lys  Val Tyr Trp Asp Thr  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1130                 1135                 1140             


Pro Thr  Val Ala Tyr Ser Val  Phe Val Val Ala Asp  Val Glu Lys 
    1145                 1150                 1155             


Gly Lys  Ala Lys Lys Leu Lys  Thr Val Lys Glu Leu  Val Gly Ile 
    1160                 1165                 1170             


Ser Ile  Met Glu Arg Ser Phe  Phe Glu Glu Asn Pro  Val Glu Phe 
    1175                 1180                 1185             


Leu Glu  Asn Lys Gly Tyr His  Asn Ile Arg Glu Asp  Lys Leu Ile 
    1190                 1195                 1200             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Phe Glu Gly  Gly Arg Arg 
    1205                 1210                 1215             


Arg Leu  Leu Ala Ser Ala Ser  Glu Leu Gln Lys Gly  Asn Glu Met 
    1220                 1225                 1230             


Val Leu  Pro Gly Tyr Leu Val  Glu Leu Leu Tyr His  Ala His Arg 
    1235                 1240                 1245             


Ala Asp  Asn Phe Asn Ser Thr  Glu Tyr Leu Asn Tyr  Val Ser Glu 
    1250                 1255                 1260             


His Lys  Lys Glu Phe Glu Lys  Val Leu Ser Cys Val  Glu Asp Phe 
    1265                 1270                 1275             


Ala Asn  Leu Tyr Val Asp Val  Glu Lys Asn Leu Ser  Lys Ile Arg 
    1280                 1285                 1290             


Ala Val  Ala Asp Ser Met Asp  Asn Phe Ser Ile Glu  Glu Ile Ser 
    1295                 1300                 1305             


Asn Ser  Phe Ile Asn Leu Leu  Thr Leu Thr Ala Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Asp  Phe Asn Phe Leu Gly  Glu Lys Ile Pro Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Cys Leu  Thr Ala Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly 
    1355                 1360                 1365             


Glu Glu  
    1370 


<210>  689
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes serotype M49 (strain NZ131)

<400>  689

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Ile Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Leu Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 
785                 790                 795                 800 


Val Glu Thr Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Lys Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Arg Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Ile Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Val Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asp Pro Val Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Cys Phe Asp Thr Thr  Ile Gly Arg Asn Arg  Tyr Lys Ser 
    1325                 1330                 1335             


Ile Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  690
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)

<400>  690

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  691
<211>  1371
<212>  PRT
<213>  Streptococcus dysgalactiae subsp. equisimilis (strain ATCC 12394 / D166B)

<400>  691

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Ser Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Lys Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Lys Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asn Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Glu Phe Leu Ser Gly Lys Gln 
    530                 535                 540                 


Lys Glu Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Lys Tyr Ala 
625                 630                 635                 640 


Asn Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Ala Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Glu Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Ala Leu Thr  Asn Glu Ser Ile Tyr  Ala Arg Gly 
    1100                 1105                 1110             


Ser Phe  Asp Lys Leu Ile Ser  Arg Lys His Arg Phe  Glu Ser Ser 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Gly Ser  Pro Thr Val Thr Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Ser Lys Val  Gln Asp Gly Lys Val  Lys Lys Ile 
    1145                 1150                 1155             


Lys Thr  Gly Lys Glu Leu Ile  Gly Ile Thr Leu Leu  Asp Lys Leu 
    1160                 1165                 1170             


Val Phe  Glu Lys Asn Pro Leu  Lys Phe Ile Glu Asp  Lys Gly Tyr 
    1175                 1180                 1185             


Gly Asn  Val Gln Ile Asp Lys  Cys Ile Lys Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Phe Glu Asn Gly  Thr Arg Arg Met Leu  Ala Ser Val 
    1205                 1210                 1215             


Met Ala  Asn Asn Asn Ser Arg  Gly Asp Leu Gln Lys  Ala Asn Glu 
    1220                 1225                 1230             


Met Phe  Leu Pro Ala Lys Leu  Val Thr Leu Leu Tyr  His Ala His 
    1235                 1240                 1245             


Lys Ile  Glu Ser Ser Lys Glu  Leu Glu His Glu Ala  Tyr Ile Leu 
    1250                 1255                 1260             


Asp His  Tyr Asn Asp Leu Tyr  Gln Leu Leu Ser Tyr  Ile Glu Arg 
    1265                 1270                 1275             


Phe Ala  Ser Leu Tyr Val Asp  Val Glu Lys Asn Ile  Ser Lys Val 
    1280                 1285                 1290             


Lys Glu  Leu Phe Ser Asn Ile  Glu Ser Tyr Ser Ile  Ser Glu Ile 
    1295                 1300                 1305             


Cys Ser  Ser Val Ile Asn Leu  Leu Thr Leu Thr Ala  Ser Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Lys Phe Leu  Gly Thr Thr Ile Pro  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Gly  Ser Pro Gln Ser Ile  Leu Ser Ser Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1355                 1360                 1365             


Gly Gly  Asp 
    1370     


<210>  692
<211>  1375
<212>  PRT
<213>  Streptococcus infantarius (strain CJ18)

<400>  692

Met Glu Lys Ser Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Val Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Lys Glu Met Thr Lys Val Asp Glu Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Glu Glu Ser Phe Leu Thr Asp Asp Asp Lys Thr 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Ser Gln Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Asn Val Phe Val Glu Thr Tyr 
            180                 185                 190         


Asp Lys Ile Val Asp Glu Ser His Leu Ser Glu Ile Glu Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Lys Gln Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Val Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ile Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Val Glu His His Glu Asp Leu Glu Lys Leu Lys 
                325                 330                 335     


Glu Phe Ile Lys Ile Asn Lys Leu Lys Leu Tyr His Asp Ile Phe Lys 
            340                 345                 350         


Asp Lys Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Thr Ile Leu Thr Lys Ile Asp 
    370                 375                 380                 


Asp Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Asp Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ser Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Ala Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asp Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Asn Tyr His Ser Asp Glu Pro Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Val Val Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr 
                485                 490                 495     


Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


His Val Tyr Glu Thr Phe Thr Val Tyr Asn Glu Leu Thr Lys Ile Lys 
        515                 520                 525             


Tyr Val Asn Glu Gln Gly Glu Ser Phe Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys 
545                 550                 555                 560 


Ala Lys Leu Leu Ser Tyr Leu Asn Asn Glu Phe Glu Glu Phe Arg Ile 
                565                 570                 575     


Asn Asp Leu Ile Gly Leu Asp Lys Asp Ser Lys Ser Phe Asn Ala Ser 
            580                 585                 590         


Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Ser Phe Leu 
        595                 600                 605             


Asp Asp Lys Thr Asn Gly Gln Ile Ile Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Asp Met Ile His Glu Arg Leu Gln Lys Tyr 
625                 630                 635                 640 


Ser Asp Phe Phe Thr Ser Gln Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Asn Asn Lys Thr Ile Leu Asp Phe Leu Ile Asp Asp Gly 
        675                 680                 685             


His Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Glu Ser Leu Ser 
    690                 695                 700                 


Phe Lys Thr Ile Ile Gln Glu Ala Gln Val Val Gly Asp Val Asp Asp 
705                 710                 715                 720 


Ile Glu Ala Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly Asp Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gly Tyr Gly Arg Asn Lys Ser Asn Gln Arg Leu Lys Arg Leu 
    770                 775                 780                 


Gln Asp Ser Leu Lys Glu Phe Gly Ser Asp Ile Leu Ser Lys Lys Lys 
785                 790                 795                 800 


Pro Ser Tyr Val Asp Ser Lys Val Glu Asn Ser His Leu Gln Asn Asp 
                805                 810                 815     


Arg Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met Tyr Thr Gly 
            820                 825                 830         


Glu Glu Leu Asp Ile Asp Arg Leu Ser Asp Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Lys Val Leu 
    850                 855                 860                 


Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile 
865                 870                 875                 880 


Glu Ile Val Arg Asn Arg Arg Ser Tyr Trp Tyr Lys Leu Tyr Lys Ser 
                885                 890                 895     


Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Thr Glu Ala Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala 
    930                 935                 940                 


Arg Phe Asn Thr Lys Arg Asp Glu Asn Asp Lys Val Ile Arg Asp Val 
945                 950                 955                 960 


Lys Val Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe Arg Lys Glu 
                965                 970                 975     


Phe Lys Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Val  Gly Thr Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Thr Pro Glu Phe  Val Tyr Gly Glu Tyr  Lys Lys Tyr 
    1010                 1015                 1020             


Asp Val  Arg Lys Leu Ile Ala  Lys Ser Ser Asp Asp  Tyr Ser Glu 
    1025                 1030                 1035             


Met Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe Tyr Ser  Asn Leu Met 
    1040                 1045                 1050             


Asn Phe  Phe Lys Thr Glu Val  Lys Tyr Ala Asp Gly  Arg Val Phe 
    1055                 1060                 1065             


Glu Arg  Pro Asp Ile Glu Thr  Asn Ala Asp Gly Glu  Val Val Trp 
    1070                 1075                 1080             


Asn Lys  Gln Lys Asp Phe Asp  Ile Val Arg Lys Val  Leu Ser Tyr 
    1085                 1090                 1095             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Ala Gln  Thr Gly Gly 
    1100                 1105                 1110             


Phe Ser  Lys Glu Ser Ile Leu  Ser Lys Gly Asp Ser  Asp Lys Leu 
    1115                 1120                 1125             


Ile Pro  Arg Lys Thr Lys Lys  Val Tyr Trp Asn Thr  Lys Lys Tyr 
    1130                 1135                 1140             


Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr Ser Val  Leu Val Val 
    1145                 1150                 1155             


Ala Asp  Ile Glu Lys Gly Lys  Ala Lys Lys Leu Lys  Thr Val Lys 
    1160                 1165                 1170             


Glu Leu  Val Gly Ile Ser Ile  Met Glu Arg Ser Phe  Phe Glu Glu 
    1175                 1180                 1185             


Asn Pro  Val Ser Phe Leu Glu  Lys Lys Gly Tyr His  Asn Val Gln 
    1190                 1195                 1200             


Glu Asp  Lys Leu Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Phe 
    1205                 1210                 1215             


Glu Gly  Gly Arg Arg Arg Leu  Leu Ala Ser Ala Thr  Glu Leu Gln 
    1220                 1225                 1230             


Lys Gly  Asn Glu Val Met Leu  Pro Ala His Leu Val  Glu Leu Leu 
    1235                 1240                 1245             


Tyr His  Ala His Arg Ile Asp  Ser Phe Asn Ser Thr  Glu His Leu 
    1250                 1255                 1260             


Lys Tyr  Val Ser Glu His Lys  Lys Glu Phe Glu Lys  Val Leu Ser 
    1265                 1270                 1275             


Cys Val  Glu Asn Phe Ser Asn  Leu Tyr Val Asp Val  Glu Lys Asn 
    1280                 1285                 1290             


Leu Ser  Lys Val Arg Ala Ala  Ala Glu Ser Met Thr  Asn Phe Ser 
    1295                 1300                 1305             


Leu Glu  Glu Ile Ser Ala Ser  Phe Ile Asn Leu Leu  Thr Leu Thr 
    1310                 1315                 1320             


Ala Leu  Gly Ala Pro Ala Asp  Phe Asn Phe Leu Gly  Glu Lys Ile 
    1325                 1330                 1335             


Pro Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Cys Leu  Ser Ala Thr 
    1340                 1345                 1350             


Leu Ile  His Gln Ser Val Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1355                 1360                 1365             


Leu Ser  Lys Leu Gly Glu Glu  
    1370                 1375 


<210>  693
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes serotype M1

<400>  693

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  694
<211>  1371
<212>  PRT
<213>  Streptococcus pyogenes serotype M4 (strain MGAS10750)

<400>  694

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Thr Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Ile Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Ala Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asp Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Glu Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Ala Leu Thr  Asn Glu Ser Ile Tyr  Ala Arg Gly 
    1100                 1105                 1110             


Ser Phe  Asp Lys Leu Ile Ser  Arg Lys His Arg Phe  Glu Ser Ser 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Gly Ser  Pro Thr Val Thr Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Ser Lys Val  Gln Asp Gly Lys Val  Lys Lys Ile 
    1145                 1150                 1155             


Lys Thr  Gly Lys Glu Leu Ile  Gly Ile Thr Leu Leu  Asp Lys Leu 
    1160                 1165                 1170             


Val Phe  Glu Lys Asn Pro Leu  Lys Phe Ile Glu Asp  Lys Gly Tyr 
    1175                 1180                 1185             


Gly Asn  Val Gln Ile Asp Lys  Cys Ile Lys Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Phe Glu Asn Gly  Thr Arg Arg Met Leu  Ala Ser Val 
    1205                 1210                 1215             


Met Ala  Asn Asn Asn Ser Arg  Gly Asp Leu Gln Lys  Ala Asn Glu 
    1220                 1225                 1230             


Met Phe  Leu Pro Ala Lys Leu  Val Thr Leu Leu Tyr  His Ala His 
    1235                 1240                 1245             


Lys Ile  Glu Ser Ser Lys Glu  Leu Glu His Glu Ala  Tyr Ile Leu 
    1250                 1255                 1260             


Asp His  Tyr Asn Asp Leu Tyr  Gln Leu Leu Ser Tyr  Ile Glu Arg 
    1265                 1270                 1275             


Phe Ala  Ser Leu Tyr Val Asp  Val Glu Lys Asn Ile  Ser Lys Val 
    1280                 1285                 1290             


Lys Glu  Leu Phe Ser Asn Ile  Glu Ser Tyr Ser Ile  Ser Glu Ile 
    1295                 1300                 1305             


Cys Ser  Ser Val Ile Asn Leu  Leu Thr Leu Thr Ala  Ser Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Lys Phe Leu  Gly Thr Thr Ile Pro  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Gly  Ser Pro Gln Ser Ile  Leu Ser Ser Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1355                 1360                 1365             


Gly Ser  Asp 
    1370     


<210>  695
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)

<400>  695

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Leu 
            20                  25                  30          


Lys Gly Leu Gly Asn Thr Asp Arg His Gly Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Val Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Thr Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Arg Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asp Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  696
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes serotype M12 (strain MGAS9429)

<400>  696

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Ile Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Leu Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Val Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Leu Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Thr Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Phe Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  697
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes serotype M28 (strain MGAS6180)

<400>  697

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Leu Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asn Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Val Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Phe Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  698
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes serotype M2 (strain MGAS10270)

<400>  698

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Leu Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Leu Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  699
<211>  1398
<212>  PRT
<213>  Veillonella atypica ACS-134-V-Col7a

<400>  699

Met Glu Thr Gln Thr Ser Asn Gln Leu Ile Thr Ser His Leu Lys Asp 
1               5                   10                  15      


Tyr Pro Lys Gln Asp Tyr Phe Val Gly Leu Asp Ile Gly Thr Asn Ser 
            20                  25                  30          


Val Gly Trp Ala Val Thr Asn Thr Ser Tyr Glu Leu Leu Lys Phe His 
        35                  40                  45              


Ser His Lys Met Trp Gly Ser Arg Leu Phe Glu Glu Gly Glu Ser Ala 
    50                  55                  60                  


Val Thr Arg Arg Gly Phe Arg Ser Met Arg Arg Arg Leu Glu Arg Arg 
65                  70                  75                  80  


Lys Leu Arg Leu Lys Leu Leu Glu Glu Leu Phe Ala Asp Ala Met Ala 
                85                  90                  95      


Gln Val Asp Ser Thr Phe Phe Ile Arg Leu His Glu Ser Lys Tyr His 
            100                 105                 110         


Tyr Glu Asp Lys Thr Thr Gly His Ser Ser Lys His Ile Leu Phe Ile 
        115                 120                 125             


Asp Glu Asp Tyr Thr Asp Gln Asp Tyr Phe Thr Glu Tyr Pro Thr Ile 
    130                 135                 140                 


Tyr His Leu Arg Lys Asp Leu Met Glu Asn Gly Thr Asp Asp Ile Arg 
145                 150                 155                 160 


Lys Leu Phe Leu Ala Val His His Ile Leu Lys Tyr Arg Gly Asn Phe 
                165                 170                 175     


Leu Tyr Glu Gly Ala Thr Phe Asn Ser Asn Ala Phe Thr Phe Glu Asp 
            180                 185                 190         


Val Leu Lys Gln Ala Leu Val Asn Ile Thr Phe Asn Cys Phe Asp Thr 
        195                 200                 205             


Asn Ser Ala Ile Ser Ser Ile Ser Asn Ile Leu Met Glu Ser Gly Lys 
    210                 215                 220                 


Thr Lys Ser Asp Lys Ala Lys Ala Ile Glu Arg Leu Val Asp Thr Tyr 
225                 230                 235                 240 


Thr Val Phe Asp Glu Val Asn Thr Pro Asp Lys Pro Gln Lys Glu Gln 
                245                 250                 255     


Val Lys Glu Asp Lys Lys Thr Leu Lys Ala Phe Ala Asn Leu Val Leu 
            260                 265                 270         


Gly Leu Ser Ala Asn Leu Ile Asp Leu Phe Gly Ser Val Glu Asp Ile 
        275                 280                 285             


Asp Asp Asp Leu Lys Lys Leu Gln Ile Val Gly Asp Thr Tyr Asp Glu 
    290                 295                 300                 


Lys Arg Asp Glu Leu Ala Lys Val Trp Gly Asp Glu Ile His Ile Ile 
305                 310                 315                 320 


Asp Asp Cys Lys Ser Val Tyr Asp Ala Ile Ile Leu Met Ser Ile Lys 
                325                 330                 335     


Glu Pro Gly Leu Thr Ile Ser Gln Ser Lys Val Lys Ala Phe Asp Lys 
            340                 345                 350         


His Lys Glu Asp Leu Val Ile Leu Lys Ser Leu Leu Lys Leu Asp Arg 
        355                 360                 365             


Asn Val Tyr Asn Glu Met Phe Lys Ser Asp Lys Lys Gly Leu His Asn 
    370                 375                 380                 


Tyr Val His Tyr Ile Lys Gln Gly Arg Thr Glu Glu Thr Ser Cys Ser 
385                 390                 395                 400 


Arg Glu Asp Phe Tyr Lys Tyr Thr Lys Lys Ile Val Glu Gly Leu Ala 
                405                 410                 415     


Asp Ser Lys Asp Lys Glu Tyr Ile Leu Asn Glu Ile Glu Leu Gln Thr 
            420                 425                 430         


Leu Leu Pro Leu Gln Arg Ile Lys Asp Asn Gly Val Ile Pro Tyr Gln 
        435                 440                 445             


Leu His Leu Glu Glu Leu Lys Val Ile Leu Asp Lys Cys Gly Pro Lys 
    450                 455                 460                 


Phe Pro Phe Leu His Thr Val Ser Asp Gly Phe Ser Val Thr Glu Lys 
465                 470                 475                 480 


Leu Ile Lys Met Leu Glu Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 
                485                 490                 495     


Asn Thr His His Asn Ile Asp Asn Gly Gly Phe Ser Trp Ala Val Arg 
            500                 505                 510         


Lys Gln Ala Gly Arg Val Thr Pro Trp Asn Phe Glu Glu Lys Ile Asp 
        515                 520                 525             


Arg Glu Lys Ser Ala Ala Ala Phe Ile Lys Asn Leu Thr Asn Lys Cys 
    530                 535                 540                 


Thr Tyr Leu Phe Gly Glu Asp Val Leu Pro Lys Ser Ser Leu Leu Tyr 
545                 550                 555                 560 


Ser Glu Phe Met Leu Leu Asn Glu Leu Asn Asn Val Arg Ile Asp Gly 
                565                 570                 575     


Lys Ala Leu Ala Gln Gly Val Lys Gln His Leu Ile Asp Ser Ile Phe 
            580                 585                 590         


Lys Gln Asp His Lys Lys Met Thr Lys Asn Arg Ile Glu Leu Phe Leu 
        595                 600                 605             


Lys Asp Asn Asn Tyr Ile Thr Lys Lys His Lys Pro Glu Ile Thr Gly 
    610                 615                 620                 


Leu Asp Gly Glu Ile Lys Asn Asp Leu Thr Ser Tyr Arg Asp Met Val 
625                 630                 635                 640 


Arg Ile Leu Gly Asn Asn Phe Asp Val Ser Met Ala Glu Asp Ile Ile 
                645                 650                 655     


Thr Asp Ile Thr Ile Phe Gly Glu Ser Lys Lys Met Leu Arg Gln Thr 
            660                 665                 670         


Leu Arg Asn Lys Phe Gly Ser Gln Leu Asn Asp Glu Thr Ile Lys Lys 
        675                 680                 685             


Leu Ser Lys Leu Arg Tyr Arg Asp Trp Gly Arg Leu Ser Lys Lys Leu 
    690                 695                 700                 


Leu Lys Gly Ile Asp Gly Cys Asp Lys Ala Gly Asn Gly Ala Pro Lys 
705                 710                 715                 720 


Thr Ile Ile Glu Leu Met Arg Asn Asp Ser Tyr Asn Leu Met Glu Ile 
                725                 730                 735     


Leu Gly Asp Lys Phe Ser Phe Met Glu Cys Ile Glu Glu Glu Asn Ala 
            740                 745                 750         


Lys Leu Ala Gln Gly Gln Val Val Asn Pro His Asp Ile Ile Asp Glu 
        755                 760                 765             


Leu Ala Leu Ser Pro Ala Val Lys Arg Ala Val Trp Gln Ala Leu Arg 
    770                 775                 780                 


Ile Val Asp Glu Val Ala His Ile Lys Lys Ala Leu Pro Ser Arg Ile 
785                 790                 795                 800 


Phe Val Glu Val Ala Arg Thr Asn Lys Ser Glu Lys Lys Lys Lys Asp 
                805                 810                 815     


Ser Arg Gln Lys Arg Leu Ser Asp Leu Tyr Ser Ala Ile Lys Lys Asp 
            820                 825                 830         


Asp Val Leu Gln Ser Gly Leu Gln Asp Lys Glu Phe Gly Ala Leu Lys 
        835                 840                 845             


Ser Gly Leu Ala Asn Tyr Asp Asp Ala Ala Leu Arg Ser Lys Lys Leu 
    850                 855                 860                 


Tyr Leu Tyr Tyr Thr Gln Met Gly Arg Cys Ala Tyr Thr Gly Asn Ile 
865                 870                 875                 880 


Ile Asp Leu Asn Gln Leu Asn Thr Asp Asn Tyr Asp Ile Asp His Ile 
                885                 890                 895     


Tyr Pro Arg Ser Leu Thr Lys Asp Asp Ser Phe Asp Asn Leu Val Leu 
            900                 905                 910         


Cys Glu Arg Thr Ala Asn Ala Lys Lys Ser Asp Ile Tyr Pro Ile Asp 
        915                 920                 925             


Asn Arg Ile Gln Thr Lys Gln Lys Pro Phe Trp Ala Phe Leu Lys His 
    930                 935                 940                 


Gln Gly Leu Ile Ser Glu Arg Lys Tyr Glu Arg Leu Thr Arg Ile Ala 
945                 950                 955                 960 


Pro Leu Thr Ala Asp Asp Leu Ser Gly Phe Ile Ala Arg Gln Leu Val 
                965                 970                 975     


Glu Thr Asn Gln Ser Val Lys Ala Thr Thr Thr Leu Leu Arg Arg Leu 
            980                 985                 990         


Tyr Pro Asp Ile Asp Val Val Phe  Val Lys Ala Glu Asn  Val Ser Asp 
        995                 1000                 1005             


Phe Arg  His Asn Asn Asn Phe  Ile Lys Val Arg Ser  Leu Asn His 
    1010                 1015                 1020             


His His  His Ala Lys Asp Ala  Tyr Leu Asn Ile Val  Val Gly Asn 
    1025                 1030                 1035             


Val Tyr  His Glu Lys Phe Thr  Arg Asn Phe Arg Leu  Phe Phe Lys 
    1040                 1045                 1050             


Lys Asn  Gly Ala Asn Arg Thr  Tyr Asn Leu Ala Lys  Met Phe Asn 
    1055                 1060                 1065             


Tyr Asp  Val Ile Cys Thr Asn  Ala Gln Asp Gly Lys  Ala Trp Asp 
    1070                 1075                 1080             


Val Lys  Thr Ser Met Asn Thr  Val Lys Lys Met Met  Ala Ser Asn 
    1085                 1090                 1095             


Asp Val  Arg Val Thr Arg Arg  Leu Leu Glu Gln Ser  Gly Ala Leu 
    1100                 1105                 1110             


Ala Asp  Ala Thr Ile Tyr Lys  Ala Ser Val Ala Ala  Lys Ala Lys 
    1115                 1120                 1125             


Asp Gly  Ala Tyr Ile Gly Met  Lys Thr Lys Tyr Ser  Val Phe Ala 
    1130                 1135                 1140             


Asp Val  Thr Lys Tyr Gly Gly  Met Thr Lys Ile Lys  Asn Ala Tyr 
    1145                 1150                 1155             


Ser Ile  Ile Val Gln Tyr Thr  Gly Lys Lys Gly Glu  Glu Ile Lys 
    1160                 1165                 1170             


Glu Ile  Val Pro Leu Pro Ile  Tyr Leu Ile Asn Arg  Asn Ala Thr 
    1175                 1180                 1185             


Asp Ile  Glu Leu Ile Asp Tyr  Val Lys Ser Val Ile  Pro Lys Ala 
    1190                 1195                 1200             


Lys Asp  Ile Ser Ile Lys Tyr  Arg Lys Leu Cys Ile  Asn Gln Leu 
    1205                 1210                 1215             


Val Lys  Val Asn Gly Phe Tyr  Tyr Tyr Leu Gly Gly  Lys Thr Asn 
    1220                 1225                 1230             


Asp Lys  Ile Tyr Ile Asp Asn  Ala Ile Glu Leu Val  Val Pro His 
    1235                 1240                 1245             


Asp Ile  Ala Thr Tyr Ile Lys  Leu Leu Asp Lys Tyr  Asp Leu Leu 
    1250                 1255                 1260             


Arg Lys  Glu Asn Lys Thr Leu  Lys Ala Ser Ser Ile  Thr Thr Ser 
    1265                 1270                 1275             


Ile Tyr  Asn Ile Asn Thr Ser  Thr Val Val Ser Leu  Ser Asn Lys 
    1280                 1285                 1290             


Val Gly  Ile Asp Val Phe Asp  Tyr Phe Met Ser Lys  Leu Arg Thr 
    1295                 1300                 1305             


Pro Leu  Tyr Met Lys Met Lys  Gly Asn Lys Val Asp  Glu Leu Ser 
    1310                 1315                 1320             


Ser Thr  Gly Arg Ser Lys Phe  Ile Lys Met Thr Leu  Glu Glu Gln 
    1325                 1330                 1335             


Ser Ile  Tyr Leu Leu Glu Val  Leu Asn Leu Leu Thr  Asn Ser Lys 
    1340                 1345                 1350             


Thr Thr  Phe Asp Val Lys Pro  Leu Gly Ile Thr Gly  Ser Arg Ser 
    1355                 1360                 1365             


Thr Ile  Gly Val Lys Ile His  Asn Leu Asp Glu Phe  Lys Ile Ile 
    1370                 1375                 1380             


Asn Glu  Ser Ile Thr Gly Leu  Tyr Ser Asn Glu Val  Thr Ile Val 
    1385                 1390                 1395             


<210>  700
<211>  1374
<212>  PRT
<213>  Fusobacterium nucleatum subsp. vincentii ATCC 49256

<400>  700

Met Lys Lys Gln Lys Phe Ser Asp Tyr Tyr Leu Gly Phe Asp Ile Gly 
1               5                   10                  15      


Thr Asn Ser Val Gly Trp Cys Val Thr Asp Leu Asp Tyr Asn Val Leu 
            20                  25                  30          


Arg Phe Asn Lys Lys Asp Met Trp Gly Ser Arg Leu Phe Asp Glu Ala 
        35                  40                  45              


Lys Thr Ala Ala Glu Arg Arg Val Gln Arg Asn Ser Arg Arg Arg Leu 
    50                  55                  60                  


Lys Arg Arg Lys Trp Arg Leu Asn Leu Leu Glu Glu Ile Phe Ser Asp 
65                  70                  75                  80  


Glu Ile Met Lys Ile Asp Ser Asn Phe Phe Arg Arg Leu Lys Glu Ser 
                85                  90                  95      


Ser Leu Trp Leu Glu Asp Lys Asn Ser Lys Glu Lys Phe Thr Leu Phe 
            100                 105                 110         


Asn Asp Asp Asn Tyr Lys Asp Tyr Asp Phe Tyr Lys Gln Tyr Pro Thr 
        115                 120                 125             


Ile Phe His Leu Arg Asp Glu Leu Ile Lys Asn Pro Glu Lys Lys Asp 
    130                 135                 140                 


Ile Arg Leu Ile Tyr Leu Ala Leu His Ser Ile Phe Lys Ser Arg Gly 
145                 150                 155                 160 


His Phe Leu Phe Glu Gly Gln Asn Leu Lys Glu Ile Lys Asn Phe Glu 
                165                 170                 175     


Thr Leu Tyr Asn Asn Leu Ile Ser Phe Leu Glu Asp Asn Gly Ile Asn 
            180                 185                 190         


Lys Ser Ile Asp Lys Asp Asn Ile Glu Lys Leu Glu Lys Ile Ile Cys 
        195                 200                 205             


Asp Ser Gly Lys Gly Leu Lys Asp Lys Glu Lys Glu Phe Lys Gly Ile 
    210                 215                 220                 


Phe Asn Ser Asp Lys Gln Leu Val Ala Ile Phe Lys Leu Ser Val Gly 
225                 230                 235                 240 


Ser Ser Val Ser Leu Asn Asp Leu Phe Asp Thr Asp Glu Tyr Lys Lys 
                245                 250                 255     


Glu Glu Val Glu Lys Glu Lys Ile Ser Phe Arg Glu Gln Ile Tyr Glu 
            260                 265                 270         


Asp Asp Lys Pro Ile Tyr Tyr Ser Ile Leu Gly Glu Lys Ile Glu Leu 
        275                 280                 285             


Leu Asp Ile Ala Lys Ser Phe Tyr Asp Phe Met Val Leu Asn Asn Ile 
    290                 295                 300                 


Leu Ser Asp Ser Asn Tyr Ile Ser Glu Ala Lys Val Lys Leu Tyr Glu 
305                 310                 315                 320 


Glu His Lys Lys Asp Leu Lys Asn Leu Lys Tyr Ile Ile Arg Lys Tyr 
                325                 330                 335     


Asn Lys Glu Asn Tyr Asp Lys Leu Phe Lys Asp Lys Asn Glu Asn Asn 
            340                 345                 350         


Tyr Pro Ala Tyr Ile Gly Leu Asn Lys Glu Lys Asp Lys Lys Glu Val 
        355                 360                 365             


Val Glu Lys Ser Arg Leu Lys Ile Asp Asp Leu Ile Lys Val Ile Lys 
    370                 375                 380                 


Gly Tyr Leu Pro Lys Pro Glu Arg Ile Glu Glu Lys Asp Lys Thr Ile 
385                 390                 395                 400 


Phe Asn Glu Ile Leu Asn Lys Ile Glu Leu Lys Thr Ile Leu Pro Lys 
                405                 410                 415     


Gln Arg Ile Ser Asp Asn Gly Thr Leu Pro Tyr Gln Ile His Glu Val 
            420                 425                 430         


Glu Leu Glu Lys Ile Leu Glu Asn Gln Ser Lys Tyr Tyr Asp Phe Leu 
        435                 440                 445             


Asn Tyr Glu Glu Asn Gly Val Ser Thr Lys Asp Lys Leu Leu Lys Thr 
    450                 455                 460                 


Phe Lys Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn Ser Tyr His 
465                 470                 475                 480 


Lys Asp Lys Gly Gly Asn Ser Trp Ile Val Arg Lys Glu Glu Gly Lys 
                485                 490                 495     


Ile Leu Pro Trp Asn Phe Glu Gln Lys Val Asp Ile Glu Lys Ser Ala 
            500                 505                 510         


Glu Glu Phe Ile Lys Arg Met Thr Asn Lys Cys Thr Tyr Leu Asn Gly 
        515                 520                 525             


Glu Asp Val Ile Pro Lys Asp Ser Phe Leu Tyr Ser Glu Tyr Ile Ile 
    530                 535                 540                 


Leu Asn Glu Leu Asn Lys Val Gln Val Asn Asp Glu Phe Leu Asn Glu 
545                 550                 555                 560 


Glu Asn Lys Arg Lys Ile Ile Asp Glu Leu Phe Lys Glu Asn Lys Lys 
                565                 570                 575     


Val Ser Glu Lys Lys Phe Lys Glu Tyr Leu Leu Val Asn Gln Ile Ala 
            580                 585                 590         


Asn Arg Thr Val Glu Leu Lys Gly Ile Lys Asp Ser Phe Asn Ser Asn 
        595                 600                 605             


Tyr Val Ser Tyr Ile Lys Phe Lys Asp Ile Phe Gly Glu Lys Leu Asn 
    610                 615                 620                 


Leu Asp Ile Tyr Lys Glu Ile Ser Glu Lys Ser Ile Leu Trp Lys Cys 
625                 630                 635                 640 


Leu Tyr Gly Asp Asp Lys Lys Ile Phe Glu Lys Lys Ile Lys Asn Glu 
                645                 650                 655     


Tyr Gly Asp Ile Leu Asn Lys Asp Glu Ile Lys Lys Ile Asn Ser Phe 
            660                 665                 670         


Lys Phe Asn Thr Trp Gly Arg Leu Ser Glu Lys Leu Leu Thr Gly Ile 
        675                 680                 685             


Glu Phe Ile Asn Leu Glu Thr Gly Glu Cys Tyr Ser Ser Val Met Glu 
    690                 695                 700                 


Ala Leu Arg Arg Thr Asn Tyr Asn Leu Met Glu Leu Leu Ser Ser Lys 
705                 710                 715                 720 


Phe Thr Leu Gln Glu Ser Ile Asp Asn Glu Asn Lys Glu Met Asn Glu 
                725                 730                 735     


Val Ser Tyr Arg Asp Leu Ile Glu Glu Ser Tyr Val Ser Pro Ser Leu 
            740                 745                 750         


Lys Arg Ala Ile Leu Gln Thr Leu Lys Ile Tyr Glu Glu Ile Lys Lys 
        755                 760                 765             


Ile Thr Gly Arg Val Pro Lys Lys Val Phe Ile Glu Met Ala Arg Gly 
    770                 775                 780                 


Gly Asp Glu Ser Met Lys Asn Lys Lys Ile Pro Ala Arg Gln Glu Gln 
785                 790                 795                 800 


Leu Lys Lys Leu Tyr Asp Ser Cys Gly Asn Asp Ile Ala Asn Phe Ser 
                805                 810                 815     


Ile Asp Ile Lys Glu Met Lys Asn Ser Leu Ser Ser Tyr Asp Asn Asn 
            820                 825                 830         


Ser Leu Arg Gln Lys Lys Leu Tyr Leu Tyr Tyr Leu Gln Phe Gly Lys 
        835                 840                 845             


Cys Met Tyr Thr Gly Arg Glu Ile Asp Leu Asp Arg Leu Leu Gln Asn 
    850                 855                 860                 


Asn Asp Thr Tyr Asp Ile Asp His Ile Tyr Pro Arg Ser Lys Val Ile 
865                 870                 875                 880 


Lys Asp Asp Ser Phe Asp Asn Leu Val Leu Val Leu Lys Asn Glu Asn 
                885                 890                 895     


Ala Glu Lys Ser Asn Glu Tyr Pro Val Lys Lys Glu Ile Gln Glu Lys 
            900                 905                 910         


Met Lys Ser Phe Trp Arg Phe Leu Lys Glu Lys Asn Phe Ile Ser Asp 
        915                 920                 925             


Glu Lys Tyr Lys Arg Leu Thr Gly Lys Asp Asp Phe Glu Leu Arg Gly 
    930                 935                 940                 


Phe Met Ala Arg Gln Leu Val Asn Val Arg Gln Thr Thr Lys Glu Val 
945                 950                 955                 960 


Gly Lys Ile Leu Gln Gln Ile Glu Pro Glu Ile Lys Ile Val Tyr Ser 
                965                 970                 975     


Lys Ala Glu Ile Ala Ser Ser Phe Arg Glu Met Phe Asp Phe Ile Lys 
            980                 985                 990         


Val Arg Glu Leu Asn Asp Thr His  His Ala Lys Asp Ala  Tyr Leu Asn 
        995                 1000                 1005             


Ile Val  Ala Gly Asn Val Tyr  Asn Thr Lys Phe Thr  Glu Lys Pro 
    1010                 1015                 1020             


Tyr Arg  Tyr Leu Gln Glu Ile  Lys Glu Asn Tyr Asp  Val Lys Lys 
    1025                 1030                 1035             


Ile Tyr  Asn Tyr Asp Ile Lys  Asn Ala Trp Asp Lys  Glu Asn Ser 
    1040                 1045                 1050             


Leu Glu  Ile Val Lys Lys Asn  Met Glu Lys Asn Thr  Val Asn Ile 
    1055                 1060                 1065             


Thr Arg  Phe Ile Lys Glu Glu  Lys Gly Glu Leu Phe  Asn Leu Asn 
    1070                 1075                 1080             


Pro Ile  Lys Lys Gly Glu Thr  Ser Asn Glu Ile Ile  Ser Ile Lys 
    1085                 1090                 1095             


Pro Lys  Leu Tyr Asp Gly Lys  Asp Asn Lys Leu Asn  Glu Lys Tyr 
    1100                 1105                 1110             


Gly Tyr  Tyr Thr Ser Leu Lys  Ala Ala Tyr Phe Ile  Tyr Val Glu 
    1115                 1120                 1125             


His Glu  Lys Lys Asn Lys Lys  Val Lys Thr Phe Glu  Arg Ile Thr 
    1130                 1135                 1140             


Arg Ile  Asp Ser Thr Leu Ile  Lys Asn Glu Lys Asn  Leu Ile Lys 
    1145                 1150                 1155             


Tyr Leu  Val Ser Gln Lys Lys  Leu Leu Asn Pro Lys  Ile Ile Lys 
    1160                 1165                 1170             


Lys Ile  Tyr Lys Glu Gln Thr  Leu Ile Ile Asp Ser  Tyr Pro Tyr 
    1175                 1180                 1185             


Thr Phe  Thr Gly Val Asp Ser  Asn Lys Lys Val Glu  Leu Lys Asn 
    1190                 1195                 1200             


Lys Lys  Gln Leu Tyr Leu Glu  Lys Lys Tyr Glu Gln  Ile Leu Lys 
    1205                 1210                 1215             


Asn Ala  Leu Lys Phe Val Glu  Asp Asn Gln Gly Glu  Thr Glu Glu 
    1220                 1225                 1230             


Asn Tyr  Lys Phe Ile Tyr Leu  Lys Lys Arg Asn Asn  Asn Glu Lys 
    1235                 1240                 1245             


Asn Glu  Thr Ile Asp Ala Val  Lys Glu Arg Tyr Asn  Ile Glu Phe 
    1250                 1255                 1260             


Asn Glu  Met Tyr Asp Lys Phe  Leu Glu Lys Leu Ser  Ser Lys Asp 
    1265                 1270                 1275             


Tyr Lys  Asn Tyr Ile Asn Asn  Lys Leu Tyr Thr Asn  Phe Leu Asn 
    1280                 1285                 1290             


Ser Lys  Glu Lys Phe Lys Lys  Leu Lys Leu Trp Glu  Lys Ser Leu 
    1295                 1300                 1305             


Ile Leu  Arg Glu Phe Leu Lys  Ile Phe Asn Lys Asn  Thr Tyr Gly 
    1310                 1315                 1320             


Lys Tyr  Glu Ile Lys Asp Ser  Gln Thr Lys Glu Lys  Leu Phe Ser 
    1325                 1330                 1335             


Phe Pro  Glu Asp Thr Gly Arg  Ile Arg Leu Gly Gln  Ser Ser Leu 
    1340                 1345                 1350             


Gly Asn  Asn Lys Glu Leu Leu  Glu Glu Ser Val Thr  Gly Leu Phe 
    1355                 1360                 1365             


Val Lys  Lys Ile Lys Leu 
    1370                 


<210>  701
<211>  1365
<212>  PRT
<213>  Filifactor alocis ATCC 35896

<400>  701

Met Thr Lys Glu Tyr Tyr Leu Gly Leu Asp Val Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Thr Asp Ser Gln Tyr Asn Leu Cys Lys Phe Lys Lys 
            20                  25                  30          


Lys Asp Met Trp Gly Ile Arg Leu Phe Glu Ser Ala Asn Thr Ala Lys 
        35                  40                  45              


Asp Arg Arg Leu Gln Arg Gly Asn Arg Arg Arg Leu Glu Arg Lys Lys 
    50                  55                  60                  


Gln Arg Ile Asp Leu Leu Gln Glu Ile Phe Ser Pro Glu Ile Cys Lys 
65                  70                  75                  80  


Ile Asp Pro Thr Phe Phe Ile Arg Leu Asn Glu Ser Arg Leu His Leu 
                85                  90                  95      


Glu Asp Lys Ser Asn Asp Phe Lys Tyr Pro Leu Phe Ile Glu Lys Asp 
            100                 105                 110         


Tyr Ser Asp Ile Glu Tyr Tyr Lys Glu Phe Pro Thr Ile Phe His Leu 
        115                 120                 125             


Arg Lys His Leu Ile Glu Ser Glu Glu Lys Gln Asp Ile Arg Leu Ile 
    130                 135                 140                 


Tyr Leu Ala Leu His Asn Ile Ile Lys Thr Arg Gly His Phe Leu Ile 
145                 150                 155                 160 


Asp Gly Asp Leu Gln Ser Ala Lys Gln Leu Arg Pro Ile Leu Asp Thr 
                165                 170                 175     


Phe Leu Leu Ser Leu Gln Glu Glu Gln Asn Leu Ser Val Ser Leu Ser 
            180                 185                 190         


Glu Asn Gln Lys Asp Glu Tyr Glu Glu Ile Leu Lys Asn Arg Ser Ile 
        195                 200                 205             


Ala Lys Ser Glu Lys Val Lys Lys Leu Lys Asn Leu Phe Glu Ile Ser 
    210                 215                 220                 


Asp Glu Leu Glu Lys Glu Glu Lys Lys Ala Gln Ser Ala Val Ile Glu 
225                 230                 235                 240 


Asn Phe Cys Lys Phe Ile Val Gly Asn Lys Gly Asp Val Cys Lys Phe 
                245                 250                 255     


Leu Arg Val Ser Lys Glu Glu Leu Glu Ile Asp Ser Phe Ser Phe Ser 
            260                 265                 270         


Glu Gly Lys Tyr Glu Asp Asp Ile Val Lys Asn Leu Glu Glu Lys Val 
        275                 280                 285             


Pro Glu Lys Val Tyr Leu Phe Glu Gln Met Lys Ala Met Tyr Asp Trp 
    290                 295                 300                 


Asn Ile Leu Val Asp Ile Leu Glu Thr Glu Glu Tyr Ile Ser Phe Ala 
305                 310                 315                 320 


Lys Val Lys Gln Tyr Glu Lys His Lys Thr Asn Leu Arg Leu Leu Arg 
                325                 330                 335     


Asp Ile Ile Leu Lys Tyr Cys Thr Lys Asp Glu Tyr Asn Arg Met Phe 
            340                 345                 350         


Asn Asp Glu Lys Glu Ala Gly Ser Tyr Thr Ala Tyr Val Gly Lys Leu 
        355                 360                 365             


Lys Lys Asn Asn Lys Lys Tyr Trp Ile Glu Lys Lys Arg Asn Pro Glu 
    370                 375                 380                 


Glu Phe Tyr Lys Ser Leu Gly Lys Leu Leu Asp Lys Ile Glu Pro Leu 
385                 390                 395                 400 


Lys Glu Asp Leu Glu Val Leu Thr Met Met Ile Glu Glu Cys Lys Asn 
                405                 410                 415     


His Thr Leu Leu Pro Ile Gln Lys Asn Lys Asp Asn Gly Val Ile Pro 
            420                 425                 430         


His Gln Val His Glu Val Glu Leu Lys Lys Ile Leu Glu Asn Ala Lys 
        435                 440                 445             


Lys Tyr Tyr Ser Phe Leu Thr Glu Thr Asp Lys Asp Gly Tyr Ser Val 
    450                 455                 460                 


Val Gln Lys Ile Glu Ser Ile Phe Arg Phe Arg Ile Pro Tyr Tyr Val 
465                 470                 475                 480 


Gly Pro Leu Ser Thr Arg His Gln Glu Lys Gly Ser Asn Val Trp Met 
                485                 490                 495     


Val Arg Lys Pro Gly Arg Glu Asp Arg Ile Tyr Pro Trp Asn Met Glu 
            500                 505                 510         


Glu Ile Ile Asp Phe Glu Lys Ser Asn Glu Asn Phe Ile Thr Arg Met 
        515                 520                 525             


Thr Asn Lys Cys Thr Tyr Leu Ile Gly Glu Asp Val Leu Pro Lys His 
    530                 535                 540                 


Ser Leu Leu Tyr Ser Lys Tyr Met Val Leu Asn Glu Leu Asn Asn Val 
545                 550                 555                 560 


Lys Val Arg Gly Lys Lys Leu Pro Thr Ser Leu Lys Gln Lys Val Phe 
                565                 570                 575     


Glu Asp Leu Phe Glu Asn Lys Ser Lys Val Thr Gly Lys Asn Leu Leu 
            580                 585                 590         


Glu Tyr Leu Gln Ile Gln Asp Lys Asp Ile Gln Ile Asp Asp Leu Ser 
        595                 600                 605             


Gly Phe Asp Lys Asp Phe Lys Thr Ser Leu Lys Ser Tyr Leu Asp Phe 
    610                 615                 620                 


Lys Lys Gln Ile Phe Gly Glu Glu Ile Glu Lys Glu Ser Ile Gln Asn 
625                 630                 635                 640 


Met Ile Glu Asp Ile Ile Lys Trp Ile Thr Ile Tyr Gly Asn Asp Lys 
                645                 650                 655     


Glu Met Leu Lys Arg Val Ile Arg Ala Asn Tyr Ser Asn Gln Leu Thr 
            660                 665                 670         


Glu Glu Gln Met Lys Lys Ile Thr Gly Phe Gln Tyr Ser Gly Trp Gly 
        675                 680                 685             


Asn Phe Ser Lys Met Phe Leu Lys Gly Ile Ser Gly Ser Asp Val Ser 
    690                 695                 700                 


Thr Gly Glu Thr Phe Asp Ile Ile Thr Ala Met Trp Glu Thr Asp Asn 
705                 710                 715                 720 


Asn Leu Met Gln Ile Leu Ser Lys Lys Phe Thr Phe Met Asp Asn Val 
                725                 730                 735     


Glu Asp Phe Asn Ser Gly Lys Val Gly Lys Ile Asp Lys Ile Thr Tyr 
            740                 745                 750         


Asp Ser Thr Val Lys Glu Met Phe Leu Ser Pro Glu Asn Lys Arg Ala 
        755                 760                 765             


Val Trp Gln Thr Ile Gln Val Ala Glu Glu Ile Lys Lys Val Met Gly 
    770                 775                 780                 


Cys Glu Pro Lys Lys Ile Phe Ile Glu Met Ala Arg Gly Gly Glu Lys 
785                 790                 795                 800 


Val Lys Lys Arg Thr Lys Ser Arg Lys Ala Gln Leu Leu Glu Leu Tyr 
                805                 810                 815     


Ala Ala Cys Glu Glu Asp Cys Arg Glu Leu Ile Lys Glu Ile Glu Asp 
            820                 825                 830         


Arg Asp Glu Arg Asp Phe Asn Ser Met Lys Leu Phe Leu Tyr Tyr Thr 
        835                 840                 845             


Gln Phe Gly Lys Cys Met Tyr Ser Gly Asp Asp Ile Asp Ile Asn Glu 
    850                 855                 860                 


Leu Ile Arg Gly Asn Ser Lys Trp Asp Arg Asp His Ile Tyr Pro Gln 
865                 870                 875                 880 


Ser Lys Ile Lys Asp Asp Ser Ile Asp Asn Leu Val Leu Val Asn Lys 
                885                 890                 895     


Thr Tyr Asn Ala Lys Lys Ser Asn Glu Leu Leu Ser Glu Asp Ile Gln 
            900                 905                 910         


Lys Lys Met His Ser Phe Trp Leu Ser Leu Leu Asn Lys Lys Leu Ile 
        915                 920                 925             


Thr Lys Ser Lys Tyr Asp Arg Leu Thr Arg Lys Gly Asp Phe Thr Asp 
    930                 935                 940                 


Glu Glu Leu Ser Gly Phe Ile Ala Arg Gln Leu Val Glu Thr Arg Gln 
945                 950                 955                 960 


Ser Thr Lys Ala Ile Ala Asp Ile Phe Lys Gln Ile Tyr Ser Ser Glu 
                965                 970                 975     


Val Val Tyr Val Lys Ser Ser Leu Val Ser Asp Phe Arg Lys Lys Pro 
            980                 985                 990         


Leu Asn Tyr Leu Lys Ser Arg Arg  Val Asn Asp Tyr His  His Ala Lys 
        995                 1000                 1005             


Asp Ala  Tyr Leu Asn Ile Val  Val Gly Asn Val Tyr  Asn Lys Lys 
    1010                 1015                 1020             


Phe Thr  Ser Asn Pro Ile Gln  Trp Met Lys Lys Asn  Arg Asp Thr 
    1025                 1030                 1035             


Asn Tyr  Ser Leu Asn Lys Val  Phe Glu His Asp Val  Val Ile Asn 
    1040                 1045                 1050             


Gly Glu  Val Ile Trp Glu Lys  Cys Thr Tyr His Glu  Asp Thr Asn 
    1055                 1060                 1065             


Thr Tyr  Asp Gly Gly Thr Leu  Asp Arg Ile Arg Lys  Ile Val Glu 
    1070                 1075                 1080             


Arg Asp  Asn Ile Leu Tyr Thr  Glu Tyr Ala Tyr Cys  Glu Lys Gly 
    1085                 1090                 1095             


Glu Leu  Phe Asn Ala Thr Ile  Gln Asn Lys Asn Gly  Asn Ser Thr 
    1100                 1105                 1110             


Val Ser  Leu Lys Lys Gly Leu  Asp Val Lys Lys Tyr  Gly Gly Tyr 
    1115                 1120                 1125             


Phe Ser  Ala Asn Thr Ser Tyr  Phe Ser Leu Ile Glu  Phe Glu Asp 
    1130                 1135                 1140             


Lys Lys  Gly Asp Arg Ala Arg  His Ile Ile Gly Val  Pro Ile Tyr 
    1145                 1150                 1155             


Ile Ala  Asn Met Leu Glu His  Ser Pro Ser Ala Phe  Leu Glu Tyr 
    1160                 1165                 1170             


Cys Glu  Gln Lys Gly Tyr Gln  Asn Val Arg Ile Leu  Val Glu Lys 
    1175                 1180                 1185             


Ile Lys  Lys Asn Ser Leu Leu  Ile Ile Asn Gly Tyr  Pro Leu Arg 
    1190                 1195                 1200             


Ile Arg  Gly Glu Asn Glu Val  Asp Thr Ser Phe Lys  Arg Ala Ile 
    1205                 1210                 1215             


Gln Leu  Lys Leu Asp Gln Lys  Asn Tyr Glu Leu Val  Arg Asn Ile 
    1220                 1225                 1230             


Glu Lys  Phe Leu Glu Lys Tyr  Val Glu Lys Lys Gly  Asn Tyr Pro 
    1235                 1240                 1245             


Ile Asp  Glu Asn Arg Asp His  Ile Thr His Glu Lys  Met Asn Gln 
    1250                 1255                 1260             


Leu Tyr  Glu Val Leu Leu Ser  Lys Met Lys Lys Phe  Asn Lys Lys 
    1265                 1270                 1275             


Gly Met  Ala Asp Pro Ser Asp  Arg Ile Glu Lys Ser  Lys Pro Lys 
    1280                 1285                 1290             


Phe Ile  Lys Leu Glu Asp Leu  Ile Asp Lys Ile Asn  Val Ile Asn 
    1295                 1300                 1305             


Lys Met  Leu Asn Leu Leu Arg  Cys Asp Asn Asp Thr  Lys Ala Asp 
    1310                 1315                 1320             


Leu Ser  Leu Ile Glu Leu Pro  Lys Asn Ala Gly Ser  Phe Val Val 
    1325                 1330                 1335             


Lys Lys  Asn Thr Ile Gly Lys  Ser Lys Ile Ile Leu  Val Asn Gln 
    1340                 1345                 1350             


Ser Val  Thr Gly Leu Tyr Glu  Asn Arg Arg Glu Leu  
    1355                 1360                 1365 


<210>  702
<211>  1327
<212>  PRT
<213>  Solobacterium moorei F0204

<400>  702

Met Glu Gly Gln Met Lys Asn Asn Gly Asn Asn Leu Gln Gln Gly Asn 
1               5                   10                  15      


Tyr Tyr Leu Gly Leu Asp Val Gly Thr Ser Ser Val Gly Trp Ala Val 
            20                  25                  30          


Thr Asp Thr Asp Tyr Asn Val Leu Lys Phe Arg Gly Lys Ser Met Trp 
        35                  40                  45              


Gly Ala Arg Leu Phe Asp Glu Ala Ser Thr Ala Glu Glu Arg Arg Thr 
    50                  55                  60                  


His Arg Gly Asn Arg Arg Arg Leu Ala Arg Arg Lys Tyr Arg Leu Leu 
65                  70                  75                  80  


Leu Leu Glu Gln Leu Phe Glu Lys Glu Ile Arg Lys Ile Asp Asp Asn 
                85                  90                  95      


Phe Phe Val Arg Leu His Glu Ser Asn Leu Trp Ala Asp Asp Lys Ser 
            100                 105                 110         


Lys Pro Ser Lys Phe Leu Leu Phe Asn Asp Thr Asn Phe Thr Asp Lys 
        115                 120                 125             


Asp Tyr Leu Lys Lys Tyr Pro Thr Ile Tyr His Leu Arg Ser Asp Leu 
    130                 135                 140                 


Ile His Asn Ser Thr Glu His Asp Ile Arg Leu Val Phe Leu Ala Leu 
145                 150                 155                 160 


His His Leu Ile Lys Tyr Arg Gly His Phe Ile Tyr Asp Asn Ser Ala 
                165                 170                 175     


Asn Gly Asp Val Lys Thr Leu Asp Glu Ala Val Ser Asp Phe Glu Glu 
            180                 185                 190         


Tyr Leu Asn Glu Asn Asp Ile Glu Phe Asn Ile Glu Asn Lys Lys Glu 
        195                 200                 205             


Phe Ile Asn Val Leu Ser Asp Lys His Leu Thr Lys Lys Glu Lys Lys 
    210                 215                 220                 


Ile Ser Leu Lys Lys Leu Tyr Gly Asp Ile Thr Asp Ser Glu Asn Ile 
225                 230                 235                 240 


Asn Ile Ser Val Leu Ile Glu Met Leu Ser Gly Ser Ser Ile Ser Leu 
                245                 250                 255     


Ser Asn Leu Phe Lys Asp Ile Glu Phe Asp Gly Lys Gln Asn Leu Ser 
            260                 265                 270         


Leu Asp Ser Asp Ile Glu Glu Thr Leu Asn Asp Val Val Asp Ile Leu 
        275                 280                 285             


Gly Asp Asn Ile Asp Leu Leu Ile His Ala Lys Glu Val Tyr Asp Ile 
    290                 295                 300                 


Ala Val Leu Thr Ser Ser Leu Gly Lys His Lys Tyr Leu Cys Asp Ala 
305                 310                 315                 320 


Lys Val Glu Leu Phe Glu Lys Asn Lys Lys Asp Leu Met Ile Leu Lys 
                325                 330                 335     


Lys Tyr Ile Lys Lys Asn His Pro Glu Asp Tyr Lys Lys Ile Phe Ser 
            340                 345                 350         


Ser Pro Thr Glu Lys Lys Asn Tyr Ala Ala Tyr Ser Gln Thr Asn Ser 
        355                 360                 365             


Lys Asn Val Cys Ser Gln Glu Glu Phe Cys Leu Phe Ile Lys Pro Tyr 
    370                 375                 380                 


Ile Arg Asp Met Val Lys Ser Glu Asn Glu Asp Glu Val Arg Ile Ala 
385                 390                 395                 400 


Lys Glu Val Glu Asp Lys Ser Phe Leu Thr Lys Leu Lys Gly Thr Asn 
                405                 410                 415     


Asn Ser Val Val Pro Tyr Gln Ile His Glu Arg Glu Leu Asn Gln Ile 
            420                 425                 430         


Leu Lys Asn Ile Val Ala Tyr Leu Pro Phe Met Asn Asp Glu Gln Glu 
        435                 440                 445             


Asp Ile Ser Val Val Asp Lys Ile Lys Leu Ile Phe Lys Phe Lys Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Asn Thr Lys Ser Thr Arg Ser Trp Val 
465                 470                 475                 480 


Tyr Arg Ser Asp Glu Lys Ile Tyr Pro Trp Asn Phe Ser Asn Val Ile 
                485                 490                 495     


Asp Leu Asp Lys Thr Ala His Glu Phe Met Asn Arg Leu Ile Gly Arg 
            500                 505                 510         


Cys Thr Tyr Thr Asn Asp Pro Val Leu Pro Met Asp Ser Leu Leu Tyr 
        515                 520                 525             


Ser Lys Tyr Asn Val Leu Asn Glu Ile Asn Pro Ile Lys Val Asn Gly 
    530                 535                 540                 


Lys Ala Ile Pro Val Glu Val Lys Gln Ala Ile Tyr Thr Asp Leu Phe 
545                 550                 555                 560 


Glu Asn Ser Lys Lys Lys Val Thr Arg Lys Ser Ile Tyr Ile Tyr Leu 
                565                 570                 575     


Leu Lys Asn Gly Tyr Ile Glu Lys Glu Asp Ile Val Ser Gly Ile Asp 
            580                 585                 590         


Ile Glu Ile Lys Ser Lys Leu Lys Ser His His Asp Phe Thr Gln Ile 
        595                 600                 605             


Val Gln Glu Asn Lys Cys Thr Pro Glu Glu Ile Glu Arg Ile Ile Lys 
    610                 615                 620                 


Gly Ile Leu Val Tyr Ser Asp Asp Lys Ser Met Leu Arg Arg Trp Leu 
625                 630                 635                 640 


Lys Asn Asn Ile Lys Gly Leu Ser Glu Asn Asp Val Lys Tyr Leu Ala 
                645                 650                 655     


Lys Leu Asn Tyr Lys Glu Trp Gly Arg Leu Ser Lys Thr Leu Leu Thr 
            660                 665                 670         


Asp Ile Tyr Thr Ile Asn Pro Glu Asp Gly Glu Ala Cys Ser Ile Leu 
        675                 680                 685             


Asp Ile Met Trp Asn Thr Asn Ala Thr Leu Met Glu Ile Leu Ser Asn 
    690                 695                 700                 


Glu Lys Tyr Gln Phe Lys Gln Asn Ile Glu Asn Tyr Lys Ala Glu Asn 
705                 710                 715                 720 


Tyr Asp Glu Lys Gln Asn Leu His Glu Glu Leu Asp Asp Met Tyr Ile 
                725                 730                 735     


Ser Pro Ala Ala Arg Arg Ser Ile Trp Gln Ala Leu Arg Ile Val Asp 
            740                 745                 750         


Glu Ile Val Asp Ile Lys Lys Ser Ala Pro Lys Lys Ile Phe Ile Glu 
        755                 760                 765             


Met Ala Arg Glu Lys Lys Ser Ala Met Lys Lys Lys Arg Thr Glu Ser 
    770                 775                 780                 


Arg Lys Asp Thr Leu Leu Glu Leu Tyr Lys Ser Cys Lys Ser Gln Ala 
785                 790                 795                 800 


Asp Gly Phe Tyr Asp Glu Glu Leu Phe Glu Lys Leu Ser Asn Glu Ser 
                805                 810                 815     


Asn Ser Arg Leu Arg Arg Asp Gln Leu Tyr Leu Tyr Tyr Thr Gln Met 
            820                 825                 830         


Gly Arg Ser Met Tyr Thr Gly Lys Arg Ile Asp Phe Asp Lys Leu Ile 
        835                 840                 845             


Asn Asp Lys Asn Thr Tyr Asp Ile Asp His Ile Tyr Pro Arg Ser Lys 
    850                 855                 860                 


Ile Lys Asp Asp Ser Ile Thr Asn Arg Val Leu Val Glu Lys Asp Ile 
865                 870                 875                 880 


Asn Gly Glu Lys Thr Asp Ile Tyr Pro Ile Ser Glu Asp Ile Arg Gln 
                885                 890                 895     


Lys Met Gln Pro Phe Trp Lys Ile Leu Lys Glu Lys Gly Leu Ile Asn 
            900                 905                 910         


Glu Glu Lys Tyr Lys Arg Leu Thr Arg Asn Tyr Glu Leu Thr Asp Glu 
        915                 920                 925             


Glu Leu Ser Ser Phe Val Ala Arg Gln Leu Val Glu Thr Gln Gln Ser 
    930                 935                 940                 


Thr Lys Ala Leu Ala Thr Leu Leu Lys Lys Glu Tyr Pro Ser Ala Lys 
945                 950                 955                 960 


Ile Val Tyr Ser Lys Ala Gly Asn Val Ser Glu Phe Arg Asn Arg Lys 
                965                 970                 975     


Asp Lys Glu Leu Pro Lys Phe Arg Glu Ile Asn Asp Leu His His Ala 
            980                 985                 990         


Lys Asp Ala Tyr Leu Asn Ile Val  Val Gly Asn Val Tyr  Asp Thr Lys 
        995                 1000                 1005             


Phe Thr  Glu Lys Phe Phe Asn  Asn Ile Arg Asn Glu  Asn Tyr Ser 
    1010                 1015                 1020             


Leu Lys  Arg Val Phe Asp Phe  Ser Val Pro Gly Ala  Trp Asp Ala 
    1025                 1030                 1035             


Lys Gly  Ser Thr Phe Asn Thr  Ile Lys Lys Tyr Met  Ala Lys Asn 
    1040                 1045                 1050             


Asn Pro  Ile Ile Ala Phe Ala  Pro Tyr Glu Val Lys  Gly Glu Leu 
    1055                 1060                 1065             


Phe Asp  Gln Gln Ile Val Pro  Lys Gly Lys Gly Gln  Phe Pro Ile 
    1070                 1075                 1080             


Lys Gln  Gly Lys Asp Ile Glu  Lys Tyr Gly Gly Tyr  Asn Lys Leu 
    1085                 1090                 1095             


Ser Ser  Ala Phe Leu Phe Ala  Val Glu Tyr Lys Gly  Lys Lys Ala 
    1100                 1105                 1110             


Arg Glu  Arg Ser Leu Glu Thr  Val Tyr Ile Lys Asp  Val Glu Leu 
    1115                 1120                 1125             


Tyr Leu  Gln Asp Pro Ile Lys  Tyr Cys Glu Ser Val  Leu Gly Leu 
    1130                 1135                 1140             


Lys Glu  Pro Gln Ile Ile Lys  Pro Lys Ile Leu Met  Gly Ser Leu 
    1145                 1150                 1155             


Phe Ser  Ile Asn Asn Lys Lys  Leu Val Val Thr Gly  Arg Ser Gly 
    1160                 1165                 1170             


Lys Gln  Tyr Val Cys His His  Ile Tyr Gln Leu Ser  Ile Asn Asp 
    1175                 1180                 1185             


Glu Asp  Ser Gln Tyr Leu Lys  Asn Ile Ala Lys Tyr  Leu Gln Glu 
    1190                 1195                 1200             


Glu Pro  Asp Gly Asn Ile Glu  Arg Gln Asn Ile Leu  Asn Ile Thr 
    1205                 1210                 1215             


Ser Val  Asn Asn Ile Lys Leu  Phe Asp Val Leu Cys  Thr Lys Phe 
    1220                 1225                 1230             


Asn Ser  Asn Thr Tyr Glu Ile  Ile Leu Asn Ser Leu  Lys Asn Asp 
    1235                 1240                 1245             


Val Asn  Glu Gly Arg Glu Lys  Phe Ser Glu Leu Asp  Ile Leu Glu 
    1250                 1255                 1260             


Gln Cys  Asn Ile Leu Leu Gln  Leu Leu Lys Ala Phe  Lys Cys Asn 
    1265                 1270                 1275             


Arg Glu  Ser Ser Asn Leu Glu  Lys Leu Asn Asn Lys  Lys Gln Ala 
    1280                 1285                 1290             


Gly Val  Ile Val Ile Pro His  Leu Phe Thr Lys Cys  Ser Val Phe 
    1295                 1300                 1305             


Lys Val  Ile His Gln Ser Ile  Thr Gly Leu Phe Glu  Lys Glu Met 
    1310                 1315                 1320             


Asp Leu  Leu Lys 
    1325         


<210>  703
<211>  1338
<212>  PRT
<213>  Coprococcus catus GD-7

<400>  703

Met Lys Gln Glu Tyr Phe Leu Gly Leu Asp Met Gly Thr Gly Ser Leu 
1               5                   10                  15      


Gly Trp Ala Val Thr Asp Ser Thr Tyr Gln Val Met Arg Lys His Gly 
            20                  25                  30          


Lys Ala Leu Trp Gly Thr Arg Leu Phe Glu Ser Ala Ser Thr Ala Glu 
        35                  40                  45              


Glu Arg Arg Met Phe Arg Thr Ala Arg Arg Arg Leu Asp Arg Arg Asn 
    50                  55                  60                  


Trp Arg Ile Gln Val Leu Gln Glu Ile Phe Ser Glu Glu Ile Ser Lys 
65                  70                  75                  80  


Val Asp Pro Gly Phe Phe Leu Arg Met Lys Glu Ser Lys Tyr Tyr Pro 
                85                  90                  95      


Glu Asp Lys Arg Asp Ala Glu Gly Asn Cys Pro Glu Leu Pro Tyr Ala 
            100                 105                 110         


Leu Phe Val Asp Asp Asn Tyr Thr Asp Lys Asn Tyr His Lys Asp Tyr 
        115                 120                 125             


Pro Thr Ile Tyr His Leu Arg Lys Met Leu Met Glu Thr Thr Glu Ile 
    130                 135                 140                 


Pro Asp Ile Arg Leu Val Tyr Leu Val Leu His His Met Met Lys His 
145                 150                 155                 160 


Arg Gly His Phe Leu Leu Ser Gly Asp Ile Ser Gln Ile Lys Glu Phe 
                165                 170                 175     


Lys Ser Thr Phe Glu Gln Leu Ile Gln Asn Ile Gln Asp Glu Glu Leu 
            180                 185                 190         


Glu Trp His Ile Ser Leu Asp Asp Ala Ala Ile Gln Phe Val Glu His 
        195                 200                 205             


Val Leu Lys Asp Arg Asn Leu Thr Arg Ser Thr Lys Lys Ser Arg Leu 
    210                 215                 220                 


Ile Lys Gln Leu Asn Ala Lys Ser Ala Cys Glu Lys Ala Ile Leu Asn 
225                 230                 235                 240 


Leu Leu Ser Gly Gly Thr Val Lys Leu Ser Asp Ile Phe Asn Asn Lys 
                245                 250                 255     


Glu Leu Asp Glu Ser Glu Arg Pro Lys Val Ser Phe Ala Asp Ser Gly 
            260                 265                 270         


Tyr Asp Asp Tyr Ile Gly Ile Val Glu Ala Glu Leu Ala Glu Gln Tyr 
        275                 280                 285             


Tyr Ile Ile Ala Ser Ala Lys Ala Val Tyr Asp Trp Ser Val Leu Val 
    290                 295                 300                 


Glu Ile Leu Gly Asn Ser Val Ser Ile Ser Glu Ala Lys Ile Lys Val 
305                 310                 315                 320 


Tyr Gln Lys His Gln Ala Asp Leu Lys Thr Leu Lys Lys Ile Val Arg 
                325                 330                 335     


Gln Tyr Met Thr Lys Glu Asp Tyr Lys Arg Val Phe Val Asp Thr Glu 
            340                 345                 350         


Glu Lys Leu Asn Asn Tyr Ser Ala Tyr Ile Gly Met Thr Lys Lys Asn 
        355                 360                 365             


Gly Lys Lys Val Asp Leu Lys Ser Lys Gln Cys Thr Gln Ala Asp Phe 
    370                 375                 380                 


Tyr Asp Phe Leu Lys Lys Asn Val Ile Lys Val Ile Asp His Lys Glu 
385                 390                 395                 400 


Ile Thr Gln Glu Ile Glu Ser Glu Ile Glu Lys Glu Asn Phe Leu Pro 
                405                 410                 415     


Lys Gln Val Thr Lys Asp Asn Gly Val Ile Pro Tyr Gln Val His Asp 
            420                 425                 430         


Tyr Glu Leu Lys Lys Ile Leu Asp Asn Leu Gly Thr Arg Met Pro Phe 
        435                 440                 445             


Ile Lys Glu Asn Ala Glu Lys Ile Gln Gln Leu Phe Glu Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Asn Arg Val Asp Asp Gly Lys Asp Gly 
465                 470                 475                 480 


Lys Phe Thr Trp Ser Val Arg Lys Ser Asp Ala Arg Ile Tyr Pro Trp 
                485                 490                 495     


Asn Phe Thr Glu Val Ile Asp Val Glu Ala Ser Ala Glu Lys Phe Ile 
            500                 505                 510         


Arg Arg Met Thr Asn Lys Cys Thr Tyr Leu Val Gly Glu Asp Val Leu 
        515                 520                 525             


Pro Lys Asp Ser Leu Val Tyr Ser Lys Phe Met Val Leu Asn Glu Leu 
    530                 535                 540                 


Asn Asn Leu Arg Leu Asn Gly Glu Lys Ile Ser Val Glu Leu Lys Gln 
545                 550                 555                 560 


Arg Ile Tyr Glu Glu Leu Phe Cys Lys Tyr Arg Lys Val Thr Arg Lys 
                565                 570                 575     


Lys Leu Glu Arg Tyr Leu Val Ile Glu Gly Ile Ala Lys Lys Gly Val 
            580                 585                 590         


Glu Ile Thr Gly Ile Asp Gly Asp Phe Lys Ala Ser Leu Thr Ala Tyr 
        595                 600                 605             


His Asp Phe Lys Glu Arg Leu Thr Asp Val Gln Leu Ser Gln Arg Ala 
    610                 615                 620                 


Lys Glu Ala Ile Val Leu Asn Val Val Leu Phe Gly Asp Asp Lys Lys 
625                 630                 635                 640 


Leu Leu Lys Gln Arg Leu Ser Lys Met Tyr Pro Asn Leu Thr Thr Gly 
                645                 650                 655     


Gln Leu Lys Gly Ile Cys Ser Leu Ser Tyr Gln Gly Trp Gly Arg Leu 
            660                 665                 670         


Ser Lys Thr Phe Leu Glu Glu Ile Thr Val Pro Ala Pro Gly Thr Gly 
        675                 680                 685             


Glu Val Trp Asn Ile Met Thr Ala Leu Trp Gln Thr Asn Asp Asn Leu 
    690                 695                 700                 


Met Gln Leu Leu Ser Arg Asn Tyr Gly Phe Thr Asn Glu Val Glu Glu 
705                 710                 715                 720 


Phe Asn Thr Leu Lys Lys Glu Thr Asp Leu Ser Tyr Lys Thr Val Asp 
                725                 730                 735     


Glu Leu Tyr Val Ser Pro Ala Val Lys Arg Gln Ile Trp Gln Thr Leu 
            740                 745                 750         


Lys Val Val Lys Glu Ile Gln Lys Val Met Gly Asn Ala Pro Lys Arg 
        755                 760                 765             


Val Phe Val Glu Met Ala Arg Glu Lys Gln Glu Gly Lys Arg Ser Asp 
    770                 775                 780                 


Ser Arg Lys Lys Gln Leu Val Glu Leu Tyr Arg Ala Cys Lys Asn Glu 
785                 790                 795                 800 


Glu Arg Asp Trp Ile Thr Glu Leu Asn Ala Gln Ser Asp Gln Gln Leu 
                805                 810                 815     


Arg Ser Asp Lys Leu Phe Leu Tyr Tyr Ile Gln Lys Gly Arg Cys Met 
            820                 825                 830         


Tyr Ser Gly Glu Thr Ile Gln Leu Asp Glu Leu Trp Asp Asn Thr Lys 
        835                 840                 845             


Tyr Asp Ile Asp His Ile Tyr Pro Gln Ser Lys Thr Met Asp Asp Ser 
    850                 855                 860                 


Leu Asn Asn Arg Val Leu Val Lys Lys Asn Tyr Asn Ala Ile Lys Ser 
865                 870                 875                 880 


Asp Thr Tyr Pro Leu Ser Leu Asp Ile Gln Lys Lys Met Met Ser Phe 
                885                 890                 895     


Trp Lys Met Leu Gln Gln Gln Gly Phe Ile Thr Lys Glu Lys Tyr Val 
            900                 905                 910         


Arg Leu Val Arg Ser Asp Glu Leu Ser Ala Asp Glu Leu Ala Gly Phe 
        915                 920                 925             


Ile Glu Arg Gln Ile Val Glu Thr Arg Gln Ser Thr Lys Ala Val Ala 
    930                 935                 940                 


Thr Ile Leu Lys Glu Ala Leu Pro Asp Thr Glu Ile Val Tyr Val Lys 
945                 950                 955                 960 


Ala Gly Asn Val Ser Asn Phe Arg Gln Thr Tyr Glu Leu Leu Lys Val 
                965                 970                 975     


Arg Glu Met Asn Asp Leu His His Ala Lys Asp Ala Tyr Leu Asn Ile 
            980                 985                 990         


Val Val Gly Asn Ala Tyr Phe Val  Lys Phe Thr Lys Asn  Ala Ala Trp 
        995                 1000                 1005             


Phe Ile  Arg Asn Asn Pro Gly  Arg Ser Tyr Asn Leu  Lys Arg Met 
    1010                 1015                 1020             


Phe Glu  Phe Asp Ile Glu Arg  Ser Gly Glu Ile Ala  Trp Lys Ala 
    1025                 1030                 1035             


Gly Asn  Lys Gly Ser Ile Val  Thr Val Lys Lys Val  Met Gln Lys 
    1040                 1045                 1050             


Asn Asn  Ile Leu Val Thr Arg  Lys Ala Tyr Glu Val  Lys Gly Gly 
    1055                 1060                 1065             


Leu Phe  Asp Gln Gln Ile Met  Lys Lys Gly Lys Gly  Gln Val Pro 
    1070                 1075                 1080             


Ile Lys  Gly Asn Asp Glu Arg  Leu Ala Asp Ile Glu  Lys Tyr Gly 
    1085                 1090                 1095             


Gly Tyr  Asn Lys Ala Ala Gly  Thr Tyr Phe Met Leu  Val Lys Ser 
    1100                 1105                 1110             


Leu Asp  Lys Lys Gly Lys Glu  Ile Arg Thr Ile Glu  Phe Val Pro 
    1115                 1120                 1125             


Leu Tyr  Leu Lys Asn Gln Ile  Glu Ile Asn His Glu  Ser Ala Ile 
    1130                 1135                 1140             


Gln Tyr  Leu Ala Gln Glu Arg  Gly Leu Asn Ser Pro  Glu Ile Leu 
    1145                 1150                 1155             


Leu Ser  Lys Ile Lys Ile Asp  Thr Leu Phe Lys Val  Asp Gly Phe 
    1160                 1165                 1170             


Lys Met  Trp Leu Ser Gly Arg  Thr Gly Asn Gln Leu  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ala  Asn Gln Leu Ile Leu  Ser His Gln Glu Ala  Ala Ile Leu 
    1190                 1195                 1200             


Lys Gly  Val Val Lys Tyr Val  Asn Arg Lys Asn Glu  Asn Lys Asp 
    1205                 1210                 1215             


Ala Lys  Leu Ser Glu Arg Asp  Gly Met Thr Glu Glu  Lys Leu Leu 
    1220                 1225                 1230             


Gln Leu  Tyr Asp Thr Phe Leu  Asp Lys Leu Ser Asn  Thr Val Tyr 
    1235                 1240                 1245             


Ser Ile  Arg Leu Ser Ala Gln  Ile Lys Thr Leu Thr  Glu Lys Arg 
    1250                 1255                 1260             


Ala Lys  Phe Ile Gly Leu Ser  Asn Glu Asp Gln Cys  Ile Val Leu 
    1265                 1270                 1275             


Asn Glu  Ile Leu His Met Phe  Gln Cys Gln Ser Gly  Ser Ala Asn 
    1280                 1285                 1290             


Leu Lys  Leu Ile Gly Gly Pro  Gly Ser Ala Gly Ile  Leu Val Met 
    1295                 1300                 1305             


Asn Asn  Asn Ile Thr Ala Cys  Lys Gln Ile Ser Val  Ile Asn Gln 
    1310                 1315                 1320             


Ser Pro  Thr Gly Ile Tyr Glu  Lys Glu Ile Asp Leu  Ile Lys Leu 
    1325                 1330                 1335             


<210>  704
<211>  1395
<212>  PRT
<213>  Treponema denticola ATCC 35405

<400>  704

Met Lys Lys Glu Ile Lys Asp Tyr Phe Leu Gly Leu Asp Val Gly Thr 
1               5                   10                  15      


Gly Ser Val Gly Trp Ala Val Thr Asp Thr Asp Tyr Lys Leu Leu Lys 
            20                  25                  30          


Ala Asn Arg Lys Asp Leu Trp Gly Met Arg Cys Phe Glu Thr Ala Glu 
        35                  40                  45              


Thr Ala Glu Val Arg Arg Leu His Arg Gly Ala Arg Arg Arg Ile Glu 
    50                  55                  60                  


Arg Arg Lys Lys Arg Ile Lys Leu Leu Gln Glu Leu Phe Ser Gln Glu 
65                  70                  75                  80  


Ile Ala Lys Thr Asp Glu Gly Phe Phe Gln Arg Met Lys Glu Ser Pro 
                85                  90                  95      


Phe Tyr Ala Glu Asp Lys Thr Ile Leu Gln Glu Asn Thr Leu Phe Asn 
            100                 105                 110         


Asp Lys Asp Phe Ala Asp Lys Thr Tyr His Lys Ala Tyr Pro Thr Ile 
        115                 120                 125             


Asn His Leu Ile Lys Ala Trp Ile Glu Asn Lys Val Lys Pro Asp Pro 
    130                 135                 140                 


Arg Leu Leu Tyr Leu Ala Cys His Asn Ile Ile Lys Lys Arg Gly His 
145                 150                 155                 160 


Phe Leu Phe Glu Gly Asp Phe Asp Ser Glu Asn Gln Phe Asp Thr Ser 
                165                 170                 175     


Ile Gln Ala Leu Phe Glu Tyr Leu Arg Glu Asp Met Glu Val Asp Ile 
            180                 185                 190         


Asp Ala Asp Ser Gln Lys Val Lys Glu Ile Leu Lys Asp Ser Ser Leu 
        195                 200                 205             


Lys Asn Ser Glu Lys Gln Ser Arg Leu Asn Lys Ile Leu Gly Leu Lys 
    210                 215                 220                 


Pro Ser Asp Lys Gln Lys Lys Ala Ile Thr Asn Leu Ile Ser Gly Asn 
225                 230                 235                 240 


Lys Ile Asn Phe Ala Asp Leu Tyr Asp Asn Pro Asp Leu Lys Asp Ala 
                245                 250                 255     


Glu Lys Asn Ser Ile Ser Phe Ser Lys Asp Asp Phe Asp Ala Leu Ser 
            260                 265                 270         


Asp Asp Leu Ala Ser Ile Leu Gly Asp Ser Phe Glu Leu Leu Leu Lys 
        275                 280                 285             


Ala Lys Ala Val Tyr Asn Cys Ser Val Leu Ser Lys Val Ile Gly Asp 
    290                 295                 300                 


Glu Gln Tyr Leu Ser Phe Ala Lys Val Lys Ile Tyr Glu Lys His Lys 
305                 310                 315                 320 


Thr Asp Leu Thr Lys Leu Lys Asn Val Ile Lys Lys His Phe Pro Lys 
                325                 330                 335     


Asp Tyr Lys Lys Val Phe Gly Tyr Asn Lys Asn Glu Lys Asn Asn Asn 
            340                 345                 350         


Asn Tyr Ser Gly Tyr Val Gly Val Cys Lys Thr Lys Ser Lys Lys Leu 
        355                 360                 365             


Ile Ile Asn Asn Ser Val Asn Gln Glu Asp Phe Tyr Lys Phe Leu Lys 
    370                 375                 380                 


Thr Ile Leu Ser Ala Lys Ser Glu Ile Lys Glu Val Asn Asp Ile Leu 
385                 390                 395                 400 


Thr Glu Ile Glu Thr Gly Thr Phe Leu Pro Lys Gln Ile Ser Lys Ser 
                405                 410                 415     


Asn Ala Glu Ile Pro Tyr Gln Leu Arg Lys Met Glu Leu Glu Lys Ile 
            420                 425                 430         


Leu Ser Asn Ala Glu Lys His Phe Ser Phe Leu Lys Gln Lys Asp Glu 
        435                 440                 445             


Lys Gly Leu Ser His Ser Glu Lys Ile Ile Met Leu Leu Thr Phe Lys 
    450                 455                 460                 


Ile Pro Tyr Tyr Ile Gly Pro Ile Asn Asp Asn His Lys Lys Phe Phe 
465                 470                 475                 480 


Pro Asp Arg Cys Trp Val Val Lys Lys Glu Lys Ser Pro Ser Gly Lys 
                485                 490                 495     


Thr Thr Pro Trp Asn Phe Phe Asp His Ile Asp Lys Glu Lys Thr Ala 
            500                 505                 510         


Glu Ala Phe Ile Thr Ser Arg Thr Asn Phe Cys Thr Tyr Leu Val Gly 
        515                 520                 525             


Glu Ser Val Leu Pro Lys Ser Ser Leu Leu Tyr Ser Glu Tyr Thr Val 
    530                 535                 540                 


Leu Asn Glu Ile Asn Asn Leu Gln Ile Ile Ile Asp Gly Lys Asn Ile 
545                 550                 555                 560 


Cys Asp Ile Lys Leu Lys Gln Lys Ile Tyr Glu Asp Leu Phe Lys Lys 
                565                 570                 575     


Tyr Lys Lys Ile Thr Gln Lys Gln Ile Ser Thr Phe Ile Lys His Glu 
            580                 585                 590         


Gly Ile Cys Asn Lys Thr Asp Glu Val Ile Ile Leu Gly Ile Asp Lys 
        595                 600                 605             


Glu Cys Thr Ser Ser Leu Lys Ser Tyr Ile Glu Leu Lys Asn Ile Phe 
    610                 615                 620                 


Gly Lys Gln Val Asp Glu Ile Ser Thr Lys Asn Met Leu Glu Glu Ile 
625                 630                 635                 640 


Ile Arg Trp Ala Thr Ile Tyr Asp Glu Gly Glu Gly Lys Thr Ile Leu 
                645                 650                 655     


Lys Thr Lys Ile Lys Ala Glu Tyr Gly Lys Tyr Cys Ser Asp Glu Gln 
            660                 665                 670         


Ile Lys Lys Ile Leu Asn Leu Lys Phe Ser Gly Trp Gly Arg Leu Ser 
        675                 680                 685             


Arg Lys Phe Leu Glu Thr Val Thr Ser Glu Met Pro Gly Phe Ser Glu 
    690                 695                 700                 


Pro Val Asn Ile Ile Thr Ala Met Arg Glu Thr Gln Asn Asn Leu Met 
705                 710                 715                 720 


Glu Leu Leu Ser Ser Glu Phe Thr Phe Thr Glu Asn Ile Lys Lys Ile 
                725                 730                 735     


Asn Ser Gly Phe Glu Asp Ala Glu Lys Gln Phe Ser Tyr Asp Gly Leu 
            740                 745                 750         


Val Lys Pro Leu Phe Leu Ser Pro Ser Val Lys Lys Met Leu Trp Gln 
        755                 760                 765             


Thr Leu Lys Leu Val Lys Glu Ile Ser His Ile Thr Gln Ala Pro Pro 
    770                 775                 780                 


Lys Lys Ile Phe Ile Glu Met Ala Lys Gly Ala Glu Leu Glu Pro Ala 
785                 790                 795                 800 


Arg Thr Lys Thr Arg Leu Lys Ile Leu Gln Asp Leu Tyr Asn Asn Cys 
                805                 810                 815     


Lys Asn Asp Ala Asp Ala Phe Ser Ser Glu Ile Lys Asp Leu Ser Gly 
            820                 825                 830         


Lys Ile Glu Asn Glu Asp Asn Leu Arg Leu Arg Ser Asp Lys Leu Tyr 
        835                 840                 845             


Leu Tyr Tyr Thr Gln Leu Gly Lys Cys Met Tyr Cys Gly Lys Pro Ile 
    850                 855                 860                 


Glu Ile Gly His Val Phe Asp Thr Ser Asn Tyr Asp Ile Asp His Ile 
865                 870                 875                 880 


Tyr Pro Gln Ser Lys Ile Lys Asp Asp Ser Ile Ser Asn Arg Val Leu 
                885                 890                 895     


Val Cys Ser Ser Cys Asn Lys Asn Lys Glu Asp Lys Tyr Pro Leu Lys 
            900                 905                 910         


Ser Glu Ile Gln Ser Lys Gln Arg Gly Phe Trp Asn Phe Leu Gln Arg 
        915                 920                 925             


Asn Asn Phe Ile Ser Leu Glu Lys Leu Asn Arg Leu Thr Arg Ala Thr 
    930                 935                 940                 


Pro Ile Ser Asp Asp Glu Thr Ala Lys Phe Ile Ala Arg Gln Leu Val 
945                 950                 955                 960 


Glu Thr Arg Gln Ala Thr Lys Val Ala Ala Lys Val Leu Glu Lys Met 
                965                 970                 975     


Phe Pro Glu Thr Lys Ile Val Tyr Ser Lys Ala Glu Thr Val Ser Met 
            980                 985                 990         


Phe Arg Asn Lys Phe Asp Ile Val  Lys Cys Arg Glu Ile  Asn Asp Phe 
        995                 1000                 1005             


His His  Ala His Asp Ala Tyr  Leu Asn Ile Val Val  Gly Asn Val 
    1010                 1015                 1020             


Tyr Asn  Thr Lys Phe Thr Asn  Asn Pro Trp Asn Phe  Ile Lys Glu 
    1025                 1030                 1035             


Lys Arg  Asp Asn Pro Lys Ile  Ala Asp Thr Tyr Asn  Tyr Tyr Lys 
    1040                 1045                 1050             


Val Phe  Asp Tyr Asp Val Lys  Arg Asn Asn Ile Thr  Ala Trp Glu 
    1055                 1060                 1065             


Lys Gly  Lys Thr Ile Ile Thr  Val Lys Asp Met Leu  Lys Arg Asn 
    1070                 1075                 1080             


Thr Pro  Ile Tyr Thr Arg Gln  Ala Ala Cys Lys Lys  Gly Glu Leu 
    1085                 1090                 1095             


Phe Asn  Gln Thr Ile Met Lys  Lys Gly Leu Gly Gln  His Pro Leu 
    1100                 1105                 1110             


Lys Lys  Glu Gly Pro Phe Ser  Asn Ile Ser Lys Tyr  Gly Gly Tyr 
    1115                 1120                 1125             


Asn Lys  Val Ser Ala Ala Tyr  Tyr Thr Leu Ile Glu  Tyr Glu Glu 
    1130                 1135                 1140             


Lys Gly  Asn Lys Ile Arg Ser  Leu Glu Thr Ile Pro  Leu Tyr Leu 
    1145                 1150                 1155             


Val Lys  Asp Ile Gln Lys Asp  Gln Asp Val Leu Lys  Ser Tyr Leu 
    1160                 1165                 1170             


Thr Asp  Leu Leu Gly Lys Lys  Glu Phe Lys Ile Leu  Val Pro Lys 
    1175                 1180                 1185             


Ile Lys  Ile Asn Ser Leu Leu  Lys Ile Asn Gly Phe  Pro Cys His 
    1190                 1195                 1200             


Ile Thr  Gly Lys Thr Asn Asp  Ser Phe Leu Leu Arg  Pro Ala Val 
    1205                 1210                 1215             


Gln Phe  Cys Cys Ser Asn Asn  Glu Val Leu Tyr Phe  Lys Lys Ile 
    1220                 1225                 1230             


Ile Arg  Phe Ser Glu Ile Arg  Ser Gln Arg Glu Lys  Ile Gly Lys 
    1235                 1240                 1245             


Thr Ile  Ser Pro Tyr Glu Asp  Leu Ser Phe Arg Ser  Tyr Ile Lys 
    1250                 1255                 1260             


Glu Asn  Leu Trp Lys Lys Thr  Lys Asn Asp Glu Ile  Gly Glu Lys 
    1265                 1270                 1275             


Glu Phe  Tyr Asp Leu Leu Gln  Lys Lys Asn Leu Glu  Ile Tyr Asp 
    1280                 1285                 1290             


Met Leu  Leu Thr Lys His Lys  Asp Thr Ile Tyr Lys  Lys Arg Pro 
    1295                 1300                 1305             


Asn Ser  Ala Thr Ile Asp Ile  Leu Val Lys Gly Lys  Glu Lys Phe 
    1310                 1315                 1320             


Lys Ser  Leu Ile Ile Glu Asn  Gln Phe Glu Val Ile  Leu Glu Ile 
    1325                 1330                 1335             


Leu Lys  Leu Phe Ser Ala Thr  Arg Asn Val Ser Asp  Leu Gln His 
    1340                 1345                 1350             


Ile Gly  Gly Ser Lys Tyr Ser  Gly Val Ala Lys Ile  Gly Asn Lys 
    1355                 1360                 1365             


Ile Ser  Ser Leu Asp Asn Cys  Ile Leu Ile Tyr Gln  Ser Ile Thr 
    1370                 1375                 1380             


Gly Ile  Phe Glu Lys Arg Ile  Asp Leu Leu Lys Val  
    1385                 1390                 1395 


<210>  705
<211>  1364
<212>  PRT
<213>  Peptoniphilus duerdenii ATCC BAA-1640

<400>  705

Met Lys Asn Leu Lys Glu Tyr Tyr Ile Gly Leu Asp Ile Gly Thr Ala 
1               5                   10                  15      


Ser Val Gly Trp Ala Val Thr Asp Glu Ser Tyr Asn Ile Pro Lys Phe 
            20                  25                  30          


Asn Gly Lys Lys Met Trp Gly Val Arg Leu Phe Asp Asp Ala Lys Thr 
        35                  40                  45              


Ala Glu Glu Arg Arg Thr Gln Arg Gly Ser Arg Arg Arg Leu Asn Arg 
    50                  55                  60                  


Arg Lys Glu Arg Ile Asn Leu Leu Gln Asp Leu Phe Ala Thr Glu Ile 
65                  70                  75                  80  


Ser Lys Val Asp Pro Asn Phe Phe Leu Arg Leu Asp Asn Ser Asp Leu 
                85                  90                  95      


Tyr Arg Glu Asp Lys Asp Glu Lys Leu Lys Ser Lys Tyr Thr Leu Phe 
            100                 105                 110         


Asn Asp Lys Asp Phe Lys Asp Arg Asp Tyr His Lys Lys Tyr Pro Thr 
        115                 120                 125             


Ile His His Leu Ile Met Asp Leu Ile Glu Asp Glu Gly Lys Lys Asp 
    130                 135                 140                 


Ile Arg Leu Leu Tyr Leu Ala Cys His Tyr Leu Leu Lys Asn Arg Gly 
145                 150                 155                 160 


His Phe Ile Phe Glu Gly Gln Lys Phe Asp Thr Lys Asn Ser Phe Asp 
                165                 170                 175     


Lys Ser Ile Asn Asp Leu Lys Ile His Leu Arg Asp Glu Tyr Asn Ile 
            180                 185                 190         


Asp Leu Glu Phe Asn Asn Glu Asp Leu Ile Glu Ile Ile Thr Asp Thr 
        195                 200                 205             


Thr Leu Asn Lys Thr Asn Lys Lys Lys Glu Leu Lys Asn Ile Val Gly 
    210                 215                 220                 


Asp Thr Lys Phe Leu Lys Ala Ile Ser Ala Ile Met Ile Gly Ser Ser 
225                 230                 235                 240 


Gln Lys Leu Val Asp Leu Phe Glu Asp Gly Glu Phe Glu Glu Thr Thr 
                245                 250                 255     


Val Lys Ser Val Asp Phe Ser Thr Thr Ala Phe Asp Asp Lys Tyr Ser 
            260                 265                 270         


Glu Tyr Glu Glu Ala Leu Gly Asp Thr Ile Ser Leu Leu Asn Ile Leu 
        275                 280                 285             


Lys Ser Ile Tyr Asp Ser Ser Ile Leu Glu Asn Leu Leu Lys Asp Ala 
    290                 295                 300                 


Asp Lys Ser Lys Asp Gly Asn Lys Tyr Ile Ser Lys Ala Phe Val Lys 
305                 310                 315                 320 


Lys Phe Asn Lys His Gly Lys Asp Leu Lys Thr Leu Lys Arg Ile Ile 
                325                 330                 335     


Lys Lys Tyr Leu Pro Ser Glu Tyr Ala Asn Ile Phe Arg Asn Lys Ser 
            340                 345                 350         


Ile Asn Asp Asn Tyr Val Ala Tyr Thr Lys Ser Asn Ile Thr Ser Asn 
        355                 360                 365             


Lys Arg Thr Lys Ala Ser Lys Phe Thr Lys Gln Glu Asp Phe Tyr Lys 
    370                 375                 380                 


Phe Ile Lys Lys His Leu Asp Thr Ile Lys Glu Thr Lys Leu Asn Ser 
385                 390                 395                 400 


Ser Glu Asn Glu Asp Leu Lys Leu Ile Asp Glu Met Leu Thr Asp Ile 
                405                 410                 415     


Glu Phe Lys Thr Phe Ile Pro Lys Leu Lys Ser Ser Asp Asn Gly Val 
            420                 425                 430         


Ile Pro Tyr Gln Leu Lys Leu Met Glu Leu Lys Lys Ile Leu Asp Asn 
        435                 440                 445             


Gln Ser Lys Tyr Tyr Asp Phe Leu Asn Glu Ser Asp Glu Tyr Gly Thr 
    450                 455                 460                 


Val Lys Asp Lys Val Glu Ser Ile Met Glu Phe Arg Ile Pro Tyr Tyr 
465                 470                 475                 480 


Val Gly Pro Leu Asn Pro Asp Ser Lys Tyr Ala Trp Ile Lys Arg Glu 
                485                 490                 495     


Asn Thr Lys Ile Thr Pro Trp Asn Phe Lys Asp Ile Val Asp Leu Asp 
            500                 505                 510         


Ser Ser Arg Glu Glu Phe Ile Asp Arg Leu Ile Gly Arg Cys Thr Tyr 
        515                 520                 525             


Leu Lys Glu Glu Lys Val Leu Pro Lys Ala Ser Leu Ile Tyr Asn Glu 
    530                 535                 540                 


Phe Met Val Leu Asn Glu Leu Asn Asn Leu Lys Leu Asn Glu Phe Leu 
545                 550                 555                 560 


Ile Thr Glu Glu Met Lys Lys Ala Ile Phe Glu Glu Leu Phe Lys Thr 
                565                 570                 575     


Lys Lys Lys Val Thr Leu Lys Ala Val Ser Asn Leu Leu Lys Lys Glu 
            580                 585                 590         


Phe Asn Leu Thr Gly Asp Ile Leu Leu Ser Gly Thr Asp Gly Asp Phe 
        595                 600                 605             


Lys Gln Gly Leu Asn Ser Tyr Ile Asp Phe Lys Asn Ile Ile Gly Asp 
    610                 615                 620                 


Lys Val Asp Arg Asp Asp Tyr Arg Ile Lys Ile Glu Glu Ile Ile Lys 
625                 630                 635                 640 


Leu Ile Val Leu Tyr Glu Asp Asp Lys Thr Tyr Leu Lys Lys Lys Ile 
                645                 650                 655     


Lys Ser Ala Tyr Lys Asn Asp Phe Thr Asp Asp Glu Ile Lys Lys Ile 
            660                 665                 670         


Ala Ala Leu Asn Tyr Lys Asp Trp Gly Arg Leu Ser Lys Arg Phe Leu 
        675                 680                 685             


Thr Gly Ile Glu Gly Val Asp Lys Thr Thr Gly Glu Lys Gly Ser Ile 
    690                 695                 700                 


Ile Tyr Phe Met Arg Glu Tyr Asn Leu Asn Leu Met Glu Leu Met Ser 
705                 710                 715                 720 


Gly His Tyr Thr Phe Thr Glu Glu Val Glu Lys Leu Asn Pro Val Glu 
                725                 730                 735     


Asn Arg Glu Leu Cys Tyr Glu Met Val Asp Glu Leu Tyr Leu Ser Pro 
            740                 745                 750         


Ser Val Lys Arg Met Leu Trp Gln Ser Leu Arg Val Val Asp Glu Ile 
        755                 760                 765             


Lys Arg Ile Ile Gly Lys Asp Pro Lys Lys Ile Phe Ile Glu Met Ala 
    770                 775                 780                 


Arg Ala Lys Glu Ala Lys Asn Ser Arg Lys Glu Ser Arg Lys Asn Lys 
785                 790                 795                 800 


Leu Leu Glu Phe Tyr Lys Phe Gly Lys Lys Ala Phe Ile Asn Glu Ile 
                805                 810                 815     


Gly Glu Glu Arg Tyr Asn Tyr Leu Leu Asn Glu Ile Asn Ser Glu Glu 
            820                 825                 830         


Glu Ser Lys Phe Arg Trp Asp Asn Leu Tyr Leu Tyr Tyr Thr Gln Leu 
        835                 840                 845             


Gly Arg Cys Met Tyr Ser Leu Glu Pro Ile Asp Leu Ala Asp Leu Lys 
    850                 855                 860                 


Ser Asn Asn Ile Tyr Asp Gln Asp His Ile Tyr Pro Lys Ser Lys Ile 
865                 870                 875                 880 


Tyr Asp Asp Ser Leu Glu Asn Arg Val Leu Val Lys Lys Asn Leu Asn 
                885                 890                 895     


His Glu Lys Gly Asn Gln Tyr Pro Ile Pro Glu Lys Val Leu Asn Lys 
            900                 905                 910         


Asn Ala Tyr Gly Phe Trp Lys Ile Leu Phe Asp Lys Gly Leu Ile Gly 
        915                 920                 925             


Gln Lys Lys Tyr Thr Arg Leu Thr Arg Arg Thr Pro Phe Glu Glu Arg 
    930                 935                 940                 


Glu Leu Ala Glu Phe Ile Glu Arg Gln Ile Val Glu Thr Arg Gln Ala 
945                 950                 955                 960 


Thr Lys Glu Thr Ala Asn Leu Leu Lys Asn Ile Cys Gln Asp Ser Glu 
                965                 970                 975     


Ile Val Tyr Ser Lys Ala Glu Asn Ala Ser Arg Phe Arg Gln Glu Phe 
            980                 985                 990         


Asp Ile Ile Lys Cys Arg Thr Val  Asn Asp Leu His His  Met His Asp 
        995                 1000                 1005             


Ala Tyr  Leu Asn Ile Val Val  Gly Asn Val Tyr Asn  Thr Lys Phe 
    1010                 1015                 1020             


Thr Lys  Asn Pro Leu Asn Phe  Ile Lys Asp Lys Asp  Asn Val Arg 
    1025                 1030                 1035             


Ser Tyr  Asn Leu Glu Asn Met  Phe Lys Tyr Asp Val  Val Arg Gly 
    1040                 1045                 1050             


Ser Tyr  Thr Ala Trp Ile Ala  Asp Asp Ser Glu Gly  Asn Val Lys 
    1055                 1060                 1065             


Ala Ala  Thr Ile Lys Lys Val  Lys Arg Glu Leu Glu  Gly Lys Asn 
    1070                 1075                 1080             


Tyr Arg  Phe Thr Arg Met Ser  Tyr Ile Gly Thr Gly  Gly Leu Tyr 
    1085                 1090                 1095             


Asp Gln  Asn Leu Met Arg Lys  Gly Lys Gly Gln Ile  Pro Gln Lys 
    1100                 1105                 1110             


Glu Asn  Thr Asn Lys Ser Asn  Ile Glu Lys Tyr Gly  Gly Tyr Asn 
    1115                 1120                 1125             


Lys Ala  Ser Ser Ala Tyr Phe  Ala Leu Ile Glu Ser  Asp Gly Lys 
    1130                 1135                 1140             


Ala Gly  Arg Glu Arg Thr Leu  Glu Thr Ile Pro Ile  Met Val Tyr 
    1145                 1150                 1155             


Asn Gln  Glu Lys Tyr Gly Asn  Thr Glu Ala Val Asp  Lys Tyr Leu 
    1160                 1165                 1170             


Lys Asp  Asn Leu Glu Leu Gln  Asp Pro Lys Ile Leu  Lys Asp Lys 
    1175                 1180                 1185             


Ile Lys  Ile Asn Ser Leu Ile  Lys Leu Asp Gly Phe  Leu Tyr Asn 
    1190                 1195                 1200             


Ile Lys  Gly Lys Thr Gly Asp  Ser Leu Ser Ile Ala  Gly Ser Val 
    1205                 1210                 1215             


Gln Leu  Ile Val Asn Lys Glu  Glu Gln Lys Leu Ile  Lys Lys Met 
    1220                 1225                 1230             


Asp Lys  Phe Leu Val Lys Lys  Lys Asp Asn Lys Asp  Ile Lys Val 
    1235                 1240                 1245             


Thr Ser  Phe Asp Asn Ile Lys  Glu Glu Glu Leu Ile  Lys Leu Tyr 
    1250                 1255                 1260             


Lys Thr  Leu Ser Asp Lys Leu  Asn Asn Gly Ile Tyr  Ser Asn Lys 
    1265                 1270                 1275             


Arg Asn  Asn Gln Ala Lys Asn  Ile Ser Glu Ala Leu  Asp Lys Phe 
    1280                 1285                 1290             


Lys Glu  Ile Ser Ile Glu Glu  Lys Ile Asp Val Leu  Asn Gln Ile 
    1295                 1300                 1305             


Ile Leu  Leu Phe Gln Ser Tyr  Asn Asn Gly Cys Asn  Leu Lys Ser 
    1310                 1315                 1320             


Ile Gly  Leu Ser Ala Lys Thr  Gly Val Val Phe Ile  Pro Lys Lys 
    1325                 1330                 1335             


Leu Asn  Tyr Lys Glu Cys Lys  Leu Ile Asn Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Phe  Glu Asn Glu Val Asp  Leu Leu Asn Leu 
    1355                 1360                 


<210>  706
<211>  1329
<212>  PRT
<213>  Catenibacterium mitsuokai DSM 15897

<400>  706

Ile Val Asp Tyr Cys Ile Gly Leu Asp Leu Gly Thr Gly Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Val Asp Met Asn His Arg Leu Met Lys Arg Asn Gly Lys 
            20                  25                  30          


His Leu Trp Gly Ser Arg Leu Phe Ser Asn Ala Glu Thr Ala Ala Asn 
        35                  40                  45              


Arg Arg Ala Ser Arg Ser Ile Arg Arg Arg Tyr Asn Lys Arg Arg Glu 
    50                  55                  60                  


Arg Ile Arg Leu Leu Arg Ala Ile Leu Gln Asp Met Val Leu Glu Lys 
65                  70                  75                  80  


Asp Pro Thr Phe Phe Ile Arg Leu Glu His Thr Ser Phe Leu Asp Glu 
                85                  90                  95      


Glu Asp Lys Ala Lys Tyr Leu Gly Thr Asp Tyr Lys Asp Asn Tyr Asn 
            100                 105                 110         


Leu Phe Ile Asp Glu Asp Phe Asn Asp Tyr Thr Tyr Tyr His Lys Tyr 
        115                 120                 125             


Pro Thr Ile Tyr His Leu Arg Lys Ala Leu Cys Glu Ser Thr Glu Lys 
    130                 135                 140                 


Ala Asp Pro Arg Leu Ile Tyr Leu Ala Leu His His Ile Val Lys Tyr 
145                 150                 155                 160 


Arg Gly Asn Phe Leu Tyr Glu Gly Gln Lys Phe Asn Met Asp Ala Ser 
                165                 170                 175     


Asn Ile Glu Asp Lys Leu Ser Asp Ile Phe Thr Gln Phe Thr Ser Phe 
            180                 185                 190         


Asn Asn Ile Pro Tyr Glu Asp Asp Glu Lys Lys Asn Leu Glu Ile Leu 
        195                 200                 205             


Glu Ile Leu Lys Lys Pro Leu Ser Lys Lys Ala Lys Val Asp Glu Val 
    210                 215                 220                 


Met Thr Leu Ile Ala Pro Glu Lys Asp Tyr Lys Ser Ala Phe Lys Glu 
225                 230                 235                 240 


Leu Val Thr Gly Ile Ala Gly Asn Lys Met Asn Val Thr Lys Met Ile 
                245                 250                 255     


Leu Cys Glu Pro Ile Lys Gln Gly Asp Ser Glu Ile Lys Leu Lys Phe 
            260                 265                 270         


Ser Asp Ser Asn Tyr Asp Asp Gln Phe Ser Glu Val Glu Lys Asp Leu 
        275                 280                 285             


Gly Glu Tyr Val Glu Phe Val Asp Ala Leu His Asn Val Tyr Ser Trp 
    290                 295                 300                 


Val Glu Leu Gln Thr Ile Met Gly Ala Thr His Thr Asp Asn Ala Ser 
305                 310                 315                 320 


Ile Ser Glu Ala Met Val Ser Arg Tyr Asn Lys His His Asp Asp Leu 
                325                 330                 335     


Lys Leu Leu Lys Asp Cys Ile Lys Asn Asn Val Pro Asn Lys Tyr Phe 
            340                 345                 350         


Asp Met Phe Arg Asn Asp Ser Glu Lys Ser Lys Gly Tyr Tyr Asn Tyr 
        355                 360                 365             


Ile Asn Arg Pro Ser Lys Ala Pro Val Asp Glu Phe Tyr Lys Tyr Val 
    370                 375                 380                 


Lys Lys Cys Ile Glu Lys Val Asp Thr Pro Glu Ala Lys Gln Ile Leu 
385                 390                 395                 400 


Asn Asp Ile Glu Leu Glu Asn Phe Leu Leu Lys Gln Asn Ser Arg Thr 
                405                 410                 415     


Asn Gly Ser Val Pro Tyr Gln Met Gln Leu Asp Glu Met Ile Lys Ile 
            420                 425                 430         


Ile Asp Asn Gln Ala Glu Tyr Tyr Pro Ile Leu Lys Glu Lys Arg Glu 
        435                 440                 445             


Gln Leu Leu Ser Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Phe Gly Pro 
    450                 455                 460                 


Leu Asn Glu Thr Ser Glu His Ala Trp Ile Lys Arg Leu Glu Gly Lys 
465                 470                 475                 480 


Glu Asn Gln Arg Ile Leu Pro Trp Asn Tyr Gln Asp Ile Val Asp Val 
                485                 490                 495     


Asp Ala Thr Ala Glu Gly Phe Ile Lys Arg Met Arg Ser Tyr Cys Thr 
            500                 505                 510         


Tyr Phe Pro Asp Glu Glu Val Leu Pro Lys Asn Ser Leu Ile Val Ser 
        515                 520                 525             


Lys Tyr Glu Val Tyr Asn Glu Leu Asn Lys Ile Arg Val Asp Asp Lys 
    530                 535                 540                 


Leu Leu Glu Val Asp Val Lys Asn Asp Ile Tyr Asn Glu Leu Phe Met 
545                 550                 555                 560 


Lys Asn Lys Thr Val Thr Glu Lys Lys Leu Lys Asn Trp Leu Val Asn 
                565                 570                 575     


Asn Gln Cys Cys Ser Lys Asp Ala Glu Ile Lys Gly Phe Gln Lys Glu 
            580                 585                 590         


Asn Gln Phe Ser Thr Ser Leu Thr Pro Trp Ile Asp Phe Thr Asn Ile 
        595                 600                 605             


Phe Gly Lys Ile Asp Gln Ser Asn Phe Asp Leu Ile Glu Asn Ile Ile 
    610                 615                 620                 


Tyr Asp Leu Thr Val Phe Glu Asp Lys Lys Ile Met Lys Arg Arg Leu 
625                 630                 635                 640 


Lys Lys Lys Tyr Ala Leu Pro Asp Asp Lys Val Lys Gln Ile Leu Lys 
                645                 650                 655     


Leu Lys Tyr Lys Asp Trp Ser Arg Leu Ser Lys Lys Leu Leu Asp Gly 
            660                 665                 670         


Ile Val Ala Asp Asn Arg Phe Gly Ser Ser Val Thr Val Leu Asp Val 
        675                 680                 685             


Leu Glu Met Ser Arg Leu Asn Leu Met Glu Ile Ile Asn Asp Lys Asp 
    690                 695                 700                 


Leu Gly Tyr Ala Gln Met Ile Glu Glu Ala Thr Ser Cys Pro Glu Asp 
705                 710                 715                 720 


Gly Lys Phe Thr Tyr Glu Glu Val Glu Arg Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Leu Lys Arg Gly Ile Trp Gln Ser Leu Gln Ile Val Glu Glu Ile Thr 
            740                 745                 750         


Lys Val Met Lys Cys Arg Pro Lys Tyr Ile Tyr Ile Glu Phe Glu Arg 
        755                 760                 765             


Ser Glu Glu Ala Lys Glu Arg Thr Glu Ser Lys Ile Lys Lys Leu Glu 
    770                 775                 780                 


Asn Val Tyr Lys Asp Leu Asp Glu Gln Thr Lys Lys Glu Tyr Lys Ser 
785                 790                 795                 800 


Val Leu Glu Glu Leu Lys Gly Phe Asp Asn Thr Lys Lys Ile Ser Ser 
                805                 810                 815     


Asp Ser Leu Phe Leu Tyr Phe Thr Gln Leu Gly Lys Cys Met Tyr Ser 
            820                 825                 830         


Gly Lys Lys Leu Asp Ile Asp Ser Leu Asp Lys Tyr Gln Ile Asp His 
        835                 840                 845             


Ile Val Pro Gln Ser Leu Val Lys Asp Asp Ser Phe Asp Asn Arg Val 
    850                 855                 860                 


Leu Val Val Pro Ser Glu Asn Gln Arg Lys Leu Asp Asp Leu Val Val 
865                 870                 875                 880 


Pro Phe Asp Ile Arg Asp Lys Met Tyr Arg Phe Trp Lys Leu Leu Phe 
                885                 890                 895     


Asp His Glu Leu Ile Ser Pro Lys Lys Phe Tyr Ser Leu Ile Lys Thr 
            900                 905                 910         


Glu Tyr Thr Glu Arg Asp Glu Glu Arg Phe Ile Asn Arg Gln Leu Val 
        915                 920                 925             


Glu Thr Arg Gln Ile Thr Lys Asn Val Thr Gln Ile Ile Glu Asp His 
    930                 935                 940                 


Tyr Ser Thr Thr Lys Val Ala Ala Ile Arg Ala Asn Leu Ser His Glu 
945                 950                 955                 960 


Phe Arg Val Lys Asn His Ile Tyr Lys Asn Arg Asp Ile Asn Asp Tyr 
                965                 970                 975     


His His Ala His Asp Ala Tyr Ile Val Ala Leu Ile Gly Gly Phe Met 
            980                 985                 990         


Arg Asp Arg Tyr Pro Asn Met His  Asp Ser Lys Ala Val  Tyr Ser Glu 
        995                 1000                 1005             


Tyr Met  Lys Met Phe Arg Lys  Asn Lys Asn Asp Gln  Lys Arg Trp 
    1010                 1015                 1020             


Lys Asp  Gly Phe Val Ile Asn  Ser Met Asn Tyr Pro  Tyr Glu Val 
    1025                 1030                 1035             


Asp Gly  Lys Leu Ile Trp Asn  Pro Asp Leu Ile Asn  Glu Ile Lys 
    1040                 1045                 1050             


Lys Cys  Phe Tyr Tyr Lys Asp  Cys Tyr Cys Thr Thr  Lys Leu Asp 
    1055                 1060                 1065             


Gln Lys  Ser Gly Gln Leu Phe  Asn Leu Thr Val Leu  Ser Asn Asp 
    1070                 1075                 1080             


Ala His  Ala Asp Lys Gly Val  Thr Lys Ala Val Val  Pro Val Asn 
    1085                 1090                 1095             


Lys Asn  Arg Ser Asp Val His  Lys Tyr Gly Gly Phe  Ser Gly Leu 
    1100                 1105                 1110             


Gln Tyr  Thr Ile Val Ala Ile  Glu Gly Gln Lys Lys  Lys Gly Lys 
    1115                 1120                 1125             


Lys Thr  Glu Leu Val Lys Lys  Ile Ser Gly Val Pro  Leu His Leu 
    1130                 1135                 1140             


Lys Ala  Ala Ser Ile Asn Glu  Lys Ile Asn Tyr Ile  Glu Glu Lys 
    1145                 1150                 1155             


Glu Gly  Leu Ser Asp Val Arg  Ile Ile Lys Asp Asn  Ile Pro Val 
    1160                 1165                 1170             


Asn Gln  Met Ile Glu Met Asp  Gly Gly Glu Tyr Leu  Leu Thr Ser 
    1175                 1180                 1185             


Pro Thr  Glu Tyr Val Asn Ala  Arg Gln Leu Val Leu  Asn Glu Lys 
    1190                 1195                 1200             


Gln Cys  Ala Leu Ile Ala Asp  Ile Tyr Asn Ala Ile  Tyr Lys Gln 
    1205                 1210                 1215             


Asp Tyr  Asp Asn Leu Asp Asp  Ile Leu Met Ile Gln  Leu Tyr Ile 
    1220                 1225                 1230             


Glu Leu  Thr Asn Lys Met Lys  Val Leu Tyr Pro Ala  Tyr Arg Gly 
    1235                 1240                 1245             


Ile Ala  Glu Lys Phe Glu Ser  Met Asn Glu Asn Tyr  Val Val Ile 
    1250                 1255                 1260             


Ser Lys  Glu Glu Lys Ala Asn  Ile Ile Lys Gln Met  Leu Ile Val 
    1265                 1270                 1275             


Met His  Arg Gly Pro Gln Asn  Gly Asn Ile Val Tyr  Asp Asp Phe 
    1280                 1285                 1290             


Lys Ile  Ser Asp Arg Ile Gly  Arg Leu Lys Thr Lys  Asn His Asn 
    1295                 1300                 1305             


Leu Asn  Asn Ile Val Phe Ile  Ser Gln Ser Pro Thr  Gly Ile Tyr 
    1310                 1315                 1320             


Thr Lys  Lys Tyr Lys Leu 
    1325                 


<210>  707
<211>  1345
<212>  PRT
<213>  Streptococcus mutans UA159

<400>  707

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Asn  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  708
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes SF370

<400>  708

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  709
<211>  1334
<212>  PRT
<213>  Listeria innocua Clip11262

<400>  709

Met Lys Lys Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Ile Ala Gly Asp Ser Glu Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Ala Asp Arg Arg Met 
    50                  55                  60                  


Ala Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Gly Ile Phe Ala Glu Glu Met Ser Lys Thr Asp Ala Asn 
                85                  90                  95      


Phe Phe Cys Arg Leu Ser Asp Ser Phe Tyr Val Asp Asn Glu Lys Arg 
            100                 105                 110         


Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Glu Tyr 
        115                 120                 125             


His Lys Asn Tyr Pro Thr Ile Tyr His Leu Arg Glu Glu Leu Val Asn 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Gln Asn Thr Ser Val Asp Gly Ile Tyr Lys Gln Phe Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Val Phe Ala Ser Gly Ile Glu Asp Gly Ser Leu Lys Lys Leu 
        195                 200                 205             


Glu Asp Asn Lys Asp Val Ala Lys Ile Leu Val Glu Lys Val Thr Arg 
    210                 215                 220                 


Lys Glu Lys Leu Glu Arg Ile Leu Lys Leu Tyr Pro Gly Glu Lys Ser 
225                 230                 235                 240 


Ala Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly Ser Lys Gly 
                245                 250                 255     


Asn Phe Gln Lys Pro Phe Asp Leu Ile Glu Lys Ser Asp Ile Glu Cys 
            260                 265                 270         


Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ser Leu Leu Ala Leu Ile 
        275                 280                 285             


Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Ala Tyr Ser 
    290                 295                 300                 


Ala Val Val Leu Ser Ser Ile Ile Thr Val Ala Glu Thr Glu Thr Asn 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Thr His Glu Glu 
                325                 330                 335     


Asp Leu Gly Glu Leu Lys Ala Phe Ile Lys Leu His Leu Pro Lys His 
            340                 345                 350         


Tyr Glu Glu Ile Phe Ser Asn Thr Glu Lys His Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Asp Gly Lys Thr Lys Gln Ala Asp Phe Tyr Lys Tyr Met Lys Met 
    370                 375                 380                 


Thr Leu Glu Asn Ile Glu Gly Ala Asp Tyr Phe Ile Ala Lys Ile Glu 
385                 390                 395                 400 


Lys Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ala Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Lys Glu Asn Tyr Asp Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Asn Gly 
    450                 455                 460                 


Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Leu Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Val Arg Tyr Ile Asn Asp Gln Gly Lys Thr Ser Tyr 
    530                 535                 540                 


Phe Ser Gly Gln Glu Lys Glu Gln Ile Phe Asn Asp Leu Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Met 
                565                 570                 575     


Ser His Val Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ser Ser Tyr Ser Thr Tyr His Asp Leu Leu Lys Val Gly Ile Lys Gln 
        595                 600                 605             


Glu Ile Leu Asp Asn Pro Val Asn Thr Glu Met Leu Glu Asn Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Gln Gln Phe Ser Asp Val Leu Asp Gly Val Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Met 
            660                 665                 670         


Gly Ile Arg Asp Lys Gln Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Thr Thr Ala 
705                 710                 715                 720 


Asp Lys Asp Ile Gln Ser Ile Val Ala Asp Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Ser Val Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Gly Lys Gly Lys Asn Asn Ser Arg Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Arg Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln Asp Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Asp Asp Val Pro Pro Leu Glu Ile Val Arg 
865                 870                 875                 880 


Lys Arg Lys Val Phe Trp Glu Lys Leu Tyr Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg Phe Asn Tyr 
    930                 935                 940                 


Glu Lys Asp Asp His Gly Asn Thr Met Lys Gln Val Arg Ile Val Thr 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Leu Tyr 
                965                 970                 975     


Lys Val Arg Asp Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Asp  Tyr His Gln Phe Asp  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Ala Gln Lys Asp  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Lys Tyr  Leu Asp Thr Val Lys  Lys Val Met 
    1055                 1060                 1065             


Ser Tyr  Arg Gln Met Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Lys Ala Thr  Ile Lys Pro Lys Gly  Asn Ser Ser 
    1085                 1090                 1095             


Lys Leu  Ile Pro Arg Lys Thr  Asn Trp Asp Pro Met  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Leu  Asp Ser Pro Asn Met  Ala Tyr Ala Val Val  Ile Glu Tyr 
    1115                 1120                 1125             


Ala Lys  Gly Lys Asn Lys Leu  Val Phe Glu Lys Lys  Ile Ile Arg 
    1130                 1135                 1140             


Val Thr  Ile Met Glu Arg Lys  Ala Phe Glu Lys Asp  Glu Lys Ala 
    1145                 1150                 1155             


Phe Leu  Glu Glu Gln Gly Tyr  Arg Gln Pro Lys Val  Leu Ala Lys 
    1160                 1165                 1170             


Leu Pro  Lys Tyr Thr Leu Tyr  Glu Cys Glu Glu Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Ala Ser Ala Asn Glu  Ala Gln Lys Gly Asn  Gln Gln Val 
    1190                 1195                 1200             


Leu Pro  Asn His Leu Val Thr  Leu Leu His His Ala  Ala Asn Cys 
    1205                 1210                 1215             


Glu Val  Ser Asp Gly Lys Ser  Leu Asp Tyr Ile Glu  Ser Asn Arg 
    1220                 1225                 1230             


Glu Met  Phe Ala Glu Leu Leu  Ala His Val Ser Glu  Phe Ala Lys 
    1235                 1240                 1245             


Arg Tyr  Thr Leu Ala Glu Ala  Asn Leu Asn Lys Ile  Asn Gln Leu 
    1250                 1255                 1260             


Phe Glu  Gln Asn Lys Glu Gly  Asp Ile Lys Ala Ile  Ala Gln Ser 
    1265                 1270                 1275             


Phe Val  Asp Leu Met Ala Phe  Asn Ala Met Gly Ala  Pro Ala Ser 
    1280                 1285                 1290             


Phe Lys  Phe Phe Glu Thr Thr  Ile Glu Arg Lys Arg  Tyr Asn Asn 
    1295                 1300                 1305             


Leu Lys  Glu Leu Leu Asn Ser  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ser Arg Lys  Arg Leu Asp Asp 
    1325                 1330                 


<210>  710
<211>  1388
<212>  PRT
<213>  Streptococcus thermophilus LMD-9

<400>  710

Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Thr Thr Asp Asn Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Ser Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Val Leu Leu Phe Asp Ser Gly Ile Thr Ala Glu Gly Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Thr Glu Met Ala Thr Leu Asp Asp Ala 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Pro Asp Asp Lys Arg 
            100                 105                 110         


Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val Glu Glu Lys Ala Tyr 
        115                 120                 125             


His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Ser Thr Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Phe Asn Ser 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Asn Phe Gln Asp Phe Leu Asp Thr Tyr 
            180                 185                 190         


Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu Asn Ser Lys Gln Leu 
        195                 200                 205             


Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Leu Glu Lys Lys Asp Arg 
    210                 215                 220                 


Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser Gly Ile Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Arg Lys Cys Phe 
                245                 250                 255     


Asn Leu Asp Glu Lys Ala Ser Leu His Phe Ser Lys Glu Ser Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Thr Leu Leu Gly Tyr Ile Gly Asp Asp Tyr Ser Asp 
        275                 280                 285             


Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Phe Leu Thr Val Thr Asp Asn Glu Thr Glu Ala Pro Leu Ser Ser Ala 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asn Glu His Lys Glu Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Glu Tyr Ile Arg Asn Ile Ser Leu Lys Thr Tyr Asn Glu Val Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Asp Phe Tyr Val Tyr Leu Lys Lys Leu Leu Ala Glu Phe Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Leu Asp Lys Gln Ala Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala Trp 
    450                 455                 460                 


Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro Trp Asn Phe Glu Asp 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu Leu Thr Lys Val Arg 
        515                 520                 525             


Phe Ile Ala Glu Ser Met Arg Asp Tyr Gln Phe Leu Asp Ser Lys Gln 
    530                 535                 540                 


Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp Lys Arg Lys Val Thr 
545                 550                 555                 560 


Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile Tyr Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ser Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys Glu Phe Leu Asp Asp 
        595                 600                 605             


Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ser Lys Phe Glu Asn 
625                 630                 635                 640 


Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Glu 
            660                 665                 670         


Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ile Ser 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ala Leu Ser Phe Lys 
    690                 695                 700                 


Lys Lys Ile Gln Lys Ala Gln Ile Ile Gly Asp Glu Asp Lys Gly Asn 
705                 710                 715                 720 


Ile Lys Glu Val Val Lys Ser Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly Gly Arg Lys Pro Glu Ser Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Tyr Thr Asn Gln Gly Lys Ser Asn Ser Gln Gln Arg Leu Lys Arg 
    770                 775                 780                 


Leu Glu Lys Ser Leu Lys Glu Leu Gly Ser Lys Ile Leu Lys Glu Asn 
785                 790                 795                 800 


Ile Pro Ala Lys Leu Ser Lys Ile Asp Asn Asn Ala Leu Gln Asn Asp 
                805                 810                 815     


Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly 
            820                 825                 830         


Asp Asp Leu Asp Ile Asp Arg Leu Ser Asn Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Gln Ala Phe Leu Lys Asp Asn Ser Ile Asp Asn Lys Val Leu 
    850                 855                 860                 


Val Ser Ser Ala Ser Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu 
865                 870                 875                 880 


Glu Val Val Lys Lys Arg Lys Thr Phe Trp Tyr Gln Leu Leu Lys Ser 
                885                 890                 895     


Lys Leu Ile Ser Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Ser Pro Glu Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Leu Leu Asp Glu 
    930                 935                 940                 


Lys Phe Asn Asn Lys Lys Asp Glu Asn Asn Arg Ala Val Arg Thr Val 
945                 950                 955                 960 


Lys Ile Ile Thr Leu Lys Ser Thr Leu Val Ser Gln Phe Arg Lys Asp 
                965                 970                 975     


Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn Asp Phe His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Val  Ala Ser Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly Asp Tyr  Pro Lys Tyr 
    1010                 1015                 1020             


Asn Ser  Phe Arg Glu Arg Lys  Ser Ala Thr Glu Lys  Val Tyr Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Ile  Phe Lys Lys Ser Ile  Ser Leu Ala 
    1040                 1045                 1050             


Asp Gly  Arg Val Ile Glu Arg  Pro Leu Ile Glu Val  Asn Glu Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ser Val Trp Asn  Lys Glu Ser Asp Leu  Ala Thr Val 
    1070                 1075                 1080             


Arg Arg  Val Leu Ser Tyr Pro  Gln Val Asn Val Val  Lys Lys Val 
    1085                 1090                 1095             


Glu Glu  Gln Asn His Gly Leu  Asp Arg Gly Lys Pro  Lys Gly Leu 
    1100                 1105                 1110             


Phe Asn  Ala Asn Leu Ser Ser  Lys Pro Lys Pro Asn  Ser Asn Glu 
    1115                 1120                 1125             


Asn Leu  Val Gly Ala Lys Glu  Tyr Leu Asp Pro Lys  Lys Tyr Gly 
    1130                 1135                 1140             


Gly Tyr  Ala Gly Ile Ser Asn  Ser Phe Thr Val Leu  Val Lys Gly 
    1145                 1150                 1155             


Thr Ile  Glu Lys Gly Ala Lys  Lys Lys Ile Thr Asn  Val Leu Glu 
    1160                 1165                 1170             


Phe Gln  Gly Ile Ser Ile Leu  Asp Arg Ile Asn Tyr  Arg Lys Asp 
    1175                 1180                 1185             


Lys Leu  Asn Phe Leu Leu Glu  Lys Gly Tyr Lys Asp  Ile Glu Leu 
    1190                 1195                 1200             


Ile Ile  Glu Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Ser Asp Gly 
    1205                 1210                 1215             


Ser Arg  Arg Met Leu Ala Ser  Ile Leu Ser Thr Asn  Asn Lys Arg 
    1220                 1225                 1230             


Gly Glu  Ile His Lys Gly Asn  Gln Ile Phe Leu Ser  Gln Lys Phe 
    1235                 1240                 1245             


Val Lys  Leu Leu Tyr His Ala  Lys Arg Ile Ser Asn  Thr Ile Asn 
    1250                 1255                 1260             


Glu Asn  His Arg Lys Tyr Val  Glu Asn His Lys Lys  Glu Phe Glu 
    1265                 1270                 1275             


Glu Leu  Phe Tyr Tyr Ile Leu  Glu Phe Asn Glu Asn  Tyr Val Gly 
    1280                 1285                 1290             


Ala Lys  Lys Asn Gly Lys Leu  Leu Asn Ser Ala Phe  Gln Ser Trp 
    1295                 1300                 1305             


Gln Asn  His Ser Ile Asp Glu  Leu Cys Ser Ser Phe  Ile Gly Pro 
    1310                 1315                 1320             


Thr Gly  Ser Glu Arg Lys Gly  Leu Phe Glu Leu Thr  Ser Arg Gly 
    1325                 1330                 1335             


Ser Ala  Ala Asp Phe Glu Phe  Leu Gly Val Lys Ile  Pro Arg Tyr 
    1340                 1345                 1350             


Arg Asp  Tyr Thr Pro Ser Ser  Leu Leu Lys Asp Ala  Thr Leu Ile 
    1355                 1360                 1365             


His Gln  Ser Val Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ala 
    1370                 1375                 1380             


Lys Leu  Gly Glu Gly 
    1385             


<210>  711
<211>  1334
<212>  PRT
<213>  Staphylococcus pseudintermedius

<400>  711

Met Gly Arg Lys Pro Tyr Ile Leu Ser Leu Asp Ile Gly Thr Gly Ser 
1               5                   10                  15      


Val Gly Tyr Ala Cys Met Asp Lys Gly Phe Asn Val Leu Lys Tyr His 
            20                  25                  30          


Asp Lys Asp Ala Leu Gly Val Tyr Leu Phe Asp Gly Ala Leu Thr Ala 
        35                  40                  45              


Gln Glu Arg Arg Gln Phe Arg Thr Ser Arg Arg Arg Lys Asn Arg Arg 
    50                  55                  60                  


Ile Lys Arg Leu Gly Leu Leu Gln Glu Leu Leu Ala Pro Leu Val Gln 
65                  70                  75                  80  


Asn Pro Asn Phe Tyr Gln Phe Gln Arg Gln Phe Ala Trp Lys Asn Asp 
                85                  90                  95      


Asn Met Asp Phe Lys Asn Lys Ser Leu Ser Glu Val Leu Ser Phe Leu 
            100                 105                 110         


Gly Tyr Glu Ser Lys Lys Tyr Pro Thr Ile Tyr His Leu Gln Glu Ala 
        115                 120                 125             


Leu Leu Leu Lys Asp Glu Lys Phe Asp Pro Glu Leu Ile Tyr Met Ala 
    130                 135                 140                 


Leu Tyr His Leu Val Lys Tyr Arg Gly His Phe Leu Phe Asp His Leu 
145                 150                 155                 160 


Lys Ile Glu Asn Leu Thr Asn Asn Asp Asn Met His Asp Phe Val Glu 
                165                 170                 175     


Leu Ile Glu Thr Tyr Glu Asn Leu Asn Asn Ile Lys Leu Asn Leu Asp 
            180                 185                 190         


Tyr Glu Lys Thr Lys Val Ile Tyr Glu Ile Leu Lys Asp Asn Glu Met 
        195                 200                 205             


Thr Lys Asn Asp Arg Ala Lys Arg Val Lys Asn Met Glu Lys Lys Leu 
    210                 215                 220                 


Glu Gln Phe Ser Ile Met Leu Leu Gly Leu Lys Phe Asn Glu Gly Lys 
225                 230                 235                 240 


Leu Phe Asn His Ala Asp Asn Ala Glu Glu Leu Lys Gly Ala Asn Gln 
                245                 250                 255     


Ser His Thr Phe Ala Asp Asn Tyr Glu Glu Asn Leu Thr Pro Phe Leu 
            260                 265                 270         


Thr Val Glu Gln Ser Glu Phe Ile Glu Arg Ala Asn Lys Ile Tyr Leu 
        275                 280                 285             


Ser Leu Thr Leu Gln Asp Ile Leu Lys Gly Lys Lys Ser Met Ala Met 
    290                 295                 300                 


Ser Lys Val Ala Ala Tyr Asp Lys Phe Arg Asn Glu Leu Lys Gln Val 
305                 310                 315                 320 


Lys Asp Ile Val Tyr Lys Ala Asp Ser Thr Arg Thr Gln Phe Lys Lys 
                325                 330                 335     


Ile Phe Val Ser Ser Lys Lys Ser Leu Lys Gln Tyr Asp Ala Thr Pro 
            340                 345                 350         


Asn Asp Gln Thr Phe Ser Ser Leu Cys Leu Phe Asp Gln Tyr Leu Ile 
        355                 360                 365             


Arg Pro Lys Lys Gln Tyr Ser Leu Leu Ile Lys Glu Leu Lys Lys Ile 
    370                 375                 380                 


Ile Pro Gln Asp Ser Glu Leu Tyr Phe Glu Ala Glu Asn Asp Thr Leu 
385                 390                 395                 400 


Leu Lys Val Leu Asn Thr Thr Asp Asn Ala Ser Ile Pro Met Gln Ile 
                405                 410                 415     


Asn Leu Tyr Glu Ala Glu Thr Ile Leu Arg Asn Gln Gln Lys Tyr His 
            420                 425                 430         


Ala Glu Ile Thr Asp Glu Met Ile Glu Lys Val Leu Ser Leu Ile Gln 
        435                 440                 445             


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Asn Asp His Thr Ala 
    450                 455                 460                 


Ser Lys Phe Gly Trp Met Glu Arg Lys Ser Asn Glu Ser Ile Lys Pro 
465                 470                 475                 480 


Trp Asn Phe Asp Glu Val Val Asp Arg Ser Lys Ser Ala Thr Gln Phe 
                485                 490                 495     


Ile Arg Arg Met Thr Asn Lys Cys Ser Tyr Leu Ile Asn Glu Asp Val 
            500                 505                 510         


Leu Pro Lys Asn Ser Leu Leu Tyr Gln Glu Met Glu Val Leu Asn Glu 
        515                 520                 525             


Leu Asn Ala Thr Gln Ile Arg Leu Gln Thr Asp Pro Lys Asn Arg Lys 
    530                 535                 540                 


Tyr Arg Met Met Pro Gln Ile Lys Leu Phe Ala Val Glu His Ile Phe 
545                 550                 555                 560 


Lys Lys Tyr Lys Thr Val Ser His Ser Lys Phe Leu Glu Ile Met Leu 
                565                 570                 575     


Asn Ser Asn His Arg Glu Asn Phe Met Asn His Gly Glu Lys Leu Ser 
            580                 585                 590         


Ile Phe Gly Thr Gln Asp Asp Lys Lys Phe Ala Ser Lys Leu Ser Ser 
        595                 600                 605             


Tyr Gln Asp Met Thr Lys Ile Phe Gly Asp Ile Glu Gly Lys Arg Ala 
    610                 615                 620                 


Gln Ile Glu Glu Ile Ile Gln Trp Ile Thr Ile Phe Glu Asp Lys Lys 
625                 630                 635                 640 


Ile Leu Val Gln Lys Leu Lys Glu Cys Tyr Pro Glu Leu Thr Ser Lys 
                645                 650                 655     


Gln Ile Asn Gln Leu Lys Lys Leu Asn Tyr Ser Gly Trp Gly Arg Leu 
            660                 665                 670         


Ser Glu Lys Leu Leu Thr His Ala Tyr Gln Gly His Ser Ile Ile Glu 
        675                 680                 685             


Leu Leu Arg His Ser Asp Glu Asn Phe Met Glu Ile Leu Thr Asn Asp 
    690                 695                 700                 


Val Tyr Gly Phe Gln Asn Phe Ile Lys Glu Glu Asn Gln Val Gln Ser 
705                 710                 715                 720 


Asn Lys Ile Gln His Gln Asp Ile Ala Asn Leu Thr Thr Ser Pro Ala 
                725                 730                 735     


Leu Lys Lys Gly Ile Trp Ser Thr Ile Lys Leu Val Arg Glu Leu Thr 
            740                 745                 750         


Ser Ile Phe Gly Glu Pro Glu Lys Ile Ile Met Glu Phe Ala Thr Glu 
        755                 760                 765             


Asp Gln Gln Lys Gly Lys Lys Gln Lys Ser Arg Lys Gln Leu Trp Asp 
    770                 775                 780                 


Asp Asn Ile Lys Lys Asn Lys Leu Lys Ser Val Asp Glu Tyr Lys Tyr 
785                 790                 795                 800 


Ile Ile Asp Val Ala Asn Lys Leu Asn Asn Glu Gln Leu Gln Gln Glu 
                805                 810                 815     


Lys Leu Trp Leu Tyr Leu Ser Gln Asn Gly Lys Cys Met Tyr Ser Gly 
            820                 825                 830         


Gln Ser Ile Asp Leu Asp Ala Leu Leu Ser Pro Asn Ala Thr Lys His 
        835                 840                 845             


Tyr Glu Val Asp His Ile Phe Pro Arg Ser Phe Ile Lys Asp Asp Ser 
    850                 855                 860                 


Ile Asp Asn Lys Val Leu Val Ile Lys Lys Met Asn Gln Thr Lys Gly 
865                 870                 875                 880 


Asp Gln Val Pro Leu Gln Phe Ile Gln Gln Pro Tyr Glu Arg Ile Ala 
                885                 890                 895     


Tyr Trp Lys Ser Leu Asn Lys Ala Gly Leu Ile Ser Asp Ser Lys Leu 
            900                 905                 910         


His Lys Leu Met Lys Pro Glu Phe Thr Ala Met Asp Lys Glu Gly Phe 
        915                 920                 925             


Ile Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Ser Val His Val Arg 
    930                 935                 940                 


Asp Phe Leu Lys Glu Glu Tyr Pro Asn Thr Lys Val Ile Pro Met Lys 
945                 950                 955                 960 


Ala Lys Met Val Ser Glu Phe Arg Lys Lys Phe Asp Ile Pro Lys Ile 
                965                 970                 975     


Arg Gln Met Asn Asp Ala His His Ala Ile Asp Ala Tyr Leu Asn Gly 
            980                 985                 990         


Val Val Tyr His Gly Ala Gln Leu  Ala Tyr Pro Asn Val  Asp Leu Phe 
        995                 1000                 1005             


Asp Phe  Asn Phe Lys Trp Glu  Lys Val Arg Glu Lys  Trp Lys Ala 
    1010                 1015                 1020             


Leu Gly  Glu Phe Asn Thr Lys  Gln Lys Ser Arg Glu  Leu Phe Phe 
    1025                 1030                 1035             


Phe Lys  Lys Leu Glu Lys Met  Glu Val Ser Gln Gly  Glu Arg Leu 
    1040                 1045                 1050             


Ile Ser  Lys Ile Lys Leu Asp  Met Asn His Phe Lys  Ile Asn Tyr 
    1055                 1060                 1065             


Ser Arg  Lys Leu Ala Asn Ile  Pro Gln Gln Phe Tyr  Asn Gln Thr 
    1070                 1075                 1080             


Ala Val  Ser Pro Lys Thr Ala  Glu Leu Lys Tyr Glu  Ser Asn Lys 
    1085                 1090                 1095             


Ser Asn  Glu Val Val Tyr Lys  Gly Leu Thr Pro Tyr  Gln Thr Tyr 
    1100                 1105                 1110             


Val Val  Ala Ile Lys Ser Val  Asn Lys Lys Gly Lys  Glu Lys Met 
    1115                 1120                 1125             


Glu Tyr  Gln Met Ile Asp His  Tyr Val Phe Asp Phe  Tyr Lys Phe 
    1130                 1135                 1140             


Gln Asn  Gly Asn Glu Lys Glu  Leu Ala Leu Tyr Leu  Ala Gln Arg 
    1145                 1150                 1155             


Glu Asn  Lys Asp Glu Val Leu  Asp Ala Gln Ile Val  Tyr Ser Leu 
    1160                 1165                 1170             


Asn Lys  Gly Asp Leu Leu Tyr  Ile Asn Asn His Pro  Cys Tyr Phe 
    1175                 1180                 1185             


Val Ser  Arg Lys Glu Val Ile  Asn Ala Lys Gln Phe  Glu Leu Thr 
    1190                 1195                 1200             


Val Glu  Gln Gln Leu Ser Leu  Tyr Asn Val Met Asn  Asn Lys Glu 
    1205                 1210                 1215             


Thr Asn  Val Glu Lys Leu Leu  Ile Glu Tyr Asp Phe  Ile Ala Glu 
    1220                 1225                 1230             


Lys Val  Ile Asn Glu Tyr His  His Tyr Leu Asn Ser  Lys Leu Lys 
    1235                 1240                 1245             


Glu Lys  Arg Val Arg Thr Phe  Phe Ser Glu Ser Asn  Gln Thr His 
    1250                 1255                 1260             


Glu Asp  Phe Ile Lys Ala Leu  Asp Glu Leu Phe Lys  Val Val Thr 
    1265                 1270                 1275             


Ala Ser  Ala Thr Arg Ser Asp  Lys Ile Gly Ser Arg  Lys Asn Ser 
    1280                 1285                 1290             


Met Thr  His Arg Ala Phe Leu  Gly Lys Gly Lys Asp  Val Lys Ile 
    1295                 1300                 1305             


Ala Tyr  Thr Ser Ile Ser Gly  Leu Lys Thr Thr Lys  Pro Lys Ser 
    1310                 1315                 1320             


Leu Phe  Lys Leu Ala Glu Ser  Arg Asn Glu Leu 
    1325                 1330                 


<210>  712
<211>  1358
<212>  PRT
<213>  Acidaminococcus intestini RyC-MR95

<400>  712

Met Gly Lys Met Tyr Tyr Leu Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Tyr Ala Val Thr Asp Pro Ser Tyr His Leu Leu Lys Phe Lys Gly 
            20                  25                  30          


Glu Pro Met Trp Gly Ala His Val Phe Ala Ala Gly Asn Gln Ser Ala 
        35                  40                  45              


Glu Arg Arg Ser Phe Arg Thr Ser Arg Arg Arg Leu Asp Arg Arg Gln 
    50                  55                  60                  


Gln Arg Val Lys Leu Val Gln Glu Ile Phe Ala Pro Val Ile Ser Pro 
65                  70                  75                  80  


Ile Asp Pro Arg Phe Phe Ile Arg Leu His Glu Ser Ala Leu Trp Arg 
                85                  90                  95      


Asp Asp Val Ala Glu Thr Asp Lys His Ile Phe Phe Asn Asp Pro Thr 
            100                 105                 110         


Tyr Thr Asp Lys Glu Tyr Tyr Ser Asp Tyr Pro Thr Ile His His Leu 
        115                 120                 125             


Ile Val Asp Leu Met Glu Ser Ser Glu Lys His Asp Pro Arg Leu Val 
    130                 135                 140                 


Tyr Leu Ala Val Ala Trp Leu Val Ala His Arg Gly His Phe Leu Asn 
145                 150                 155                 160 


Glu Val Asp Lys Asp Asn Ile Gly Asp Val Leu Ser Phe Asp Ala Phe 
                165                 170                 175     


Tyr Pro Glu Phe Leu Ala Phe Leu Ser Asp Asn Gly Val Ser Pro Trp 
            180                 185                 190         


Val Cys Glu Ser Lys Ala Leu Gln Ala Thr Leu Leu Ser Arg Asn Ser 
        195                 200                 205             


Val Asn Asp Lys Tyr Lys Ala Leu Lys Ser Leu Ile Phe Gly Ser Gln 
    210                 215                 220                 


Lys Pro Glu Asp Asn Phe Asp Ala Asn Ile Ser Glu Asp Gly Leu Ile 
225                 230                 235                 240 


Gln Leu Leu Ala Gly Lys Lys Val Lys Val Asn Lys Leu Phe Pro Gln 
                245                 250                 255     


Glu Ser Asn Asp Ala Ser Phe Thr Leu Asn Asp Lys Glu Asp Ala Ile 
            260                 265                 270         


Glu Glu Ile Leu Gly Thr Leu Thr Pro Asp Glu Cys Glu Trp Ile Ala 
        275                 280                 285             


His Ile Arg Arg Leu Phe Asp Trp Ala Ile Met Lys His Ala Leu Lys 
    290                 295                 300                 


Asp Gly Arg Thr Ile Ser Glu Ser Lys Val Lys Leu Tyr Glu Gln His 
305                 310                 315                 320 


His His Asp Leu Thr Gln Leu Lys Tyr Phe Val Lys Thr Tyr Leu Ala 
                325                 330                 335     


Lys Glu Tyr Asp Asp Ile Phe Arg Asn Val Asp Ser Glu Thr Thr Lys 
            340                 345                 350         


Asn Tyr Val Ala Tyr Ser Tyr His Val Lys Glu Val Lys Gly Thr Leu 
        355                 360                 365             


Pro Lys Asn Lys Ala Thr Gln Glu Glu Phe Cys Lys Tyr Val Leu Gly 
    370                 375                 380                 


Lys Val Lys Asn Ile Glu Cys Ser Glu Ala Asp Lys Val Asp Phe Asp 
385                 390                 395                 400 


Glu Met Ile Gln Arg Leu Thr Asp Asn Ser Phe Met Pro Lys Gln Val 
                405                 410                 415     


Ser Gly Glu Asn Arg Val Ile Pro Tyr Gln Leu Tyr Tyr Tyr Glu Leu 
            420                 425                 430         


Lys Thr Ile Leu Asn Lys Ala Ala Ser Tyr Leu Pro Phe Leu Thr Gln 
        435                 440                 445             


Cys Gly Lys Asp Ala Ile Ser Asn Gln Asp Lys Leu Leu Ser Ile Met 
    450                 455                 460                 


Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Arg Lys Asp Asn Ser 
465                 470                 475                 480 


Glu His Ala Trp Leu Glu Arg Lys Ala Gly Lys Ile Tyr Pro Trp Asn 
                485                 490                 495     


Phe Asn Asp Lys Val Asp Leu Asp Lys Ser Glu Glu Ala Phe Ile Arg 
            500                 505                 510         


Arg Met Thr Asn Thr Cys Thr Tyr Tyr Pro Gly Glu Asp Val Leu Pro 
        515                 520                 525             


Leu Asp Ser Leu Ile Tyr Glu Lys Phe Met Ile Leu Asn Glu Ile Asn 
    530                 535                 540                 


Asn Ile Arg Ile Asp Gly Tyr Pro Ile Ser Val Asp Val Lys Gln Gln 
545                 550                 555                 560 


Val Phe Gly Leu Phe Glu Lys Lys Arg Arg Val Thr Val Lys Asp Ile 
                565                 570                 575     


Gln Asn Leu Leu Leu Ser Leu Gly Ala Leu Asp Lys His Gly Lys Leu 
            580                 585                 590         


Thr Gly Ile Asp Thr Thr Ile His Ser Asn Tyr Asn Thr Tyr His His 
        595                 600                 605             


Phe Lys Ser Leu Met Glu Arg Gly Val Leu Thr Arg Asp Asp Val Glu 
    610                 615                 620                 


Arg Ile Val Glu Arg Met Thr Tyr Ser Asp Asp Thr Lys Arg Val Arg 
625                 630                 635                 640 


Leu Trp Leu Asn Asn Asn Tyr Gly Thr Leu Thr Ala Asp Asp Val Lys 
                645                 650                 655     


His Ile Ser Arg Leu Arg Lys His Asp Phe Gly Arg Leu Ser Lys Met 
            660                 665                 670         


Phe Leu Thr Gly Leu Lys Gly Val His Lys Glu Thr Gly Glu Arg Ala 
        675                 680                 685             


Ser Ile Leu Asp Phe Met Trp Asn Thr Asn Asp Asn Leu Met Gln Leu 
    690                 695                 700                 


Leu Ser Glu Cys Tyr Thr Phe Ser Asp Glu Ile Thr Lys Leu Gln Glu 
705                 710                 715                 720 


Ala Tyr Tyr Ala Lys Ala Gln Leu Ser Leu Asn Asp Phe Leu Asp Ser 
                725                 730                 735     


Met Tyr Ile Ser Asn Ala Val Lys Arg Pro Ile Tyr Arg Thr Leu Ala 
            740                 745                 750         


Val Val Asn Asp Ile Arg Lys Ala Cys Gly Thr Ala Pro Lys Arg Ile 
        755                 760                 765             


Phe Ile Glu Met Ala Arg Asp Gly Glu Ser Lys Lys Lys Arg Ser Val 
    770                 775                 780                 


Thr Arg Arg Glu Gln Ile Lys Asn Leu Tyr Arg Ser Ile Arg Lys Asp 
785                 790                 795                 800 


Phe Gln Gln Glu Val Asp Phe Leu Glu Lys Ile Leu Glu Asn Lys Ser 
                805                 810                 815     


Asp Gly Gln Leu Gln Ser Asp Ala Leu Tyr Leu Tyr Phe Ala Gln Leu 
            820                 825                 830         


Gly Arg Asp Met Tyr Thr Gly Asp Pro Ile Lys Leu Glu His Ile Lys 
        835                 840                 845             


Asp Gln Ser Phe Tyr Asn Ile Asp His Ile Tyr Pro Gln Ser Met Val 
    850                 855                 860                 


Lys Asp Asp Ser Leu Asp Asn Lys Val Leu Val Gln Ser Glu Ile Asn 
865                 870                 875                 880 


Gly Glu Lys Ser Ser Arg Tyr Pro Leu Asp Ala Ala Ile Arg Asn Lys 
                885                 890                 895     


Met Lys Pro Leu Trp Asp Ala Tyr Tyr Asn His Gly Leu Ile Ser Leu 
            900                 905                 910         


Lys Lys Tyr Gln Arg Leu Thr Arg Ser Thr Pro Phe Thr Asp Asp Glu 
        915                 920                 925             


Lys Trp Asp Phe Ile Asn Arg Gln Leu Val Glu Thr Arg Gln Ser Thr 
    930                 935                 940                 


Lys Ala Leu Ala Ile Leu Leu Lys Arg Lys Phe Pro Asp Thr Glu Ile 
945                 950                 955                 960 


Val Tyr Ser Lys Ala Gly Leu Ser Ser Asp Phe Arg His Glu Phe Gly 
                965                 970                 975     


Leu Val Lys Ser Arg Asn Ile Asn Asp Leu His His Ala Lys Asp Ala 
            980                 985                 990         


Phe Leu Ala Ile Val Thr Gly Asn  Val Tyr His Glu Arg  Phe Asn Arg 
        995                 1000                 1005             


Arg Trp  Phe Met Val Asn Gln  Pro Tyr Ser Val Lys  Thr Lys Thr 
    1010                 1015                 1020             


Leu Phe  Thr His Ser Ile Lys  Asn Gly Asn Phe Val  Ala Trp Asn 
    1025                 1030                 1035             


Gly Glu  Glu Asp Leu Gly Arg  Ile Val Lys Met Leu  Lys Gln Asn 
    1040                 1045                 1050             


Lys Asn  Thr Ile His Phe Thr  Arg Phe Ser Phe Asp  Arg Lys Glu 
    1055                 1060                 1065             


Gly Leu  Phe Asp Ile Gln Pro  Leu Lys Ala Ser Thr  Gly Leu Val 
    1070                 1075                 1080             


Pro Arg  Lys Ala Gly Leu Asp  Val Val Lys Tyr Gly  Gly Tyr Asp 
    1085                 1090                 1095             


Lys Ser  Thr Ala Ala Tyr Tyr  Leu Leu Val Arg Phe  Thr Leu Glu 
    1100                 1105                 1110             


Asp Lys  Lys Thr Gln His Lys  Leu Met Met Ile Pro  Val Glu Gly 
    1115                 1120                 1125             


Leu Tyr  Lys Ala Arg Ile Asp  His Asp Lys Glu Phe  Leu Thr Asp 
    1130                 1135                 1140             


Tyr Ala  Gln Thr Thr Ile Ser  Glu Ile Leu Gln Lys  Asp Lys Gln 
    1145                 1150                 1155             


Lys Val  Ile Asn Ile Met Phe  Pro Met Gly Thr Arg  His Ile Lys 
    1160                 1165                 1170             


Leu Asn  Ser Met Ile Ser Ile  Asp Gly Phe Tyr Leu  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ser Ser Lys Gly Lys  Ser Val Leu Cys His  Ala Met Val 
    1190                 1195                 1200             


Pro Leu  Ile Val Pro His Lys  Ile Glu Cys Tyr Ile  Lys Ala Met 
    1205                 1210                 1215             


Glu Ser  Phe Ala Arg Lys Phe  Lys Glu Asn Asn Lys  Leu Arg Ile 
    1220                 1225                 1230             


Val Glu  Lys Phe Asp Lys Ile  Thr Val Glu Asp Asn  Leu Asn Leu 
    1235                 1240                 1245             


Tyr Glu  Leu Phe Leu Gln Lys  Leu Gln His Asn Pro  Tyr Asn Lys 
    1250                 1255                 1260             


Phe Phe  Ser Thr Gln Phe Asp  Val Leu Thr Asn Gly  Arg Ser Thr 
    1265                 1270                 1275             


Phe Thr  Lys Leu Ser Pro Glu  Glu Gln Val Gln Thr  Leu Leu Asn 
    1280                 1285                 1290             


Ile Leu  Ser Ile Phe Lys Thr  Cys Arg Ser Ser Gly  Cys Asp Leu 
    1295                 1300                 1305             


Lys Ser  Ile Asn Gly Ser Ala  Gln Ala Ala Arg Ile  Met Ile Ser 
    1310                 1315                 1320             


Ala Asp  Leu Thr Gly Leu Ser  Lys Lys Tyr Ser Asp  Ile Arg Leu 
    1325                 1330                 1335             


Val Glu  Gln Ser Ala Ser Gly  Leu Phe Val Ser Lys  Ser Gln Asn 
    1340                 1345                 1350             


Leu Leu  Glu Tyr Leu 
    1355             


<210>  713
<211>  1399
<212>  PRT
<213>  Olsenella uli DSM 7084

<400>  713

Met Asn Leu Arg Asn Thr Thr Asp Glu Tyr Asn Ile Gly Leu Asp Met 
1               5                   10                  15      


Gly Thr Asn Ser Val Gly Trp Ala Val Thr Asp Lys Ala Gly Ala Ile 
            20                  25                  30          


Ala His Phe Lys Gly Lys Pro Thr Leu Gly Ser Arg Leu Phe Asp Ala 
        35                  40                  45              


Ala Gln Thr Ala Ala Gly Ala Arg Ile His Arg Ser Gln Arg Arg Arg 
    50                  55                  60                  


Tyr Val Arg Arg Arg Trp Arg Leu Asp Leu Leu Gln Ser Leu Phe Gln 
65                  70                  75                  80  


Asp Glu Val Ser Lys Val Asp Ser Glu Phe Phe Cys Arg Leu Arg Gln 
                85                  90                  95      


Ser Arg Leu Tyr Val Gly Asp Arg Glu Lys Gly His Ala Asp Tyr Thr 
            100                 105                 110         


Trp Pro Ile Phe Asn Asp Ser Asp Phe Asn Glu Val Asp Tyr Tyr Lys 
        115                 120                 125             


Arg Phe Pro Thr Ile Tyr His Leu Arg Lys Trp Leu Met Glu Thr Asp 
    130                 135                 140                 


Glu Lys Ala Asp Ile Arg Leu Ile Tyr Leu Ala Thr His Asn Ile Val 
145                 150                 155                 160 


Lys His Arg Gly Asn Phe Leu Arg Glu Asn Asn Lys Ser Leu Ser Ser 
                165                 170                 175     


Arg Asp Ala Asn Pro Ala Gln Ala Val Lys Ser Leu Arg Leu Ala Leu 
            180                 185                 190         


Asn Asp Trp Cys Ser Glu Arg Asp Tyr Glu Cys Ala Trp Lys Gly Glu 
        195                 200                 205             


Glu Asp Asp Gly Ala Ile Asp Glu Ala Ile Leu Asn Val Leu Ala Asp 
    210                 215                 220                 


Gly Glu Lys Gly Arg Ser Asp Gln Ala Lys Glu Ile Ala Lys Leu Thr 
225                 230                 235                 240 


Gly Val Asp Cys Gly Asp Ala Lys Gln Ser Lys Gln Cys Asn Glu Ala 
                245                 250                 255     


Ile Ala Lys Ala Ile Val Gly Leu Lys Val Glu Met Lys Asn Ile Phe 
            260                 265                 270         


Gly Glu Phe Pro Ala Glu Lys Thr Ser Tyr Ile Tyr Leu Ser Ser Asp 
        275                 280                 285             


Glu Asp Val Glu Ala Val Arg Glu Ser Cys Pro Asp Asp Ser Gly Glu 
    290                 295                 300                 


Leu Phe Gln Ala Leu Cys Lys Leu Tyr Ser Ala Tyr Ile Leu Gln Glu 
305                 310                 315                 320 


Leu Leu Ser Tyr Ala Asp Pro Ser Gly Gln Thr Ile Ser Ala Asn Met 
                325                 330                 335     


Val Ala Lys Tyr Lys Gln Tyr Gly Arg Asp Leu Arg Leu Leu Lys Glu 
            340                 345                 350         


Leu Thr Arg Thr Tyr Ala Pro Gln Lys Tyr Asp Leu Phe Phe Arg Gly 
        355                 360                 365             


Glu Thr Tyr Ala Gly Ser Ser Asp Tyr Val Val Asp Glu Ala Arg Gly 
    370                 375                 380                 


Tyr Thr Arg Tyr Asn Leu Gly Thr Thr Lys Ala Asn Tyr Asp Asp Phe 
385                 390                 395                 400 


Gln Lys Ser Val Lys Glu Leu Phe Lys Gly Thr Asp Ala Leu Gln Asp 
                405                 410                 415     


Glu Arg Tyr Gln Glu Met Met Val Ala Phe Gly Glu Gln Lys Phe Leu 
            420                 425                 430         


Arg Arg Leu Lys Thr Ser Asp Asn Gly Ser Ile Tyr Tyr Gln Leu His 
        435                 440                 445             


Leu Glu Glu Leu His Thr Ile Leu Glu Asn Gln Gly Lys His Tyr Pro 
    450                 455                 460                 


Phe Leu Leu Ser Glu Glu Asp Lys Ile Glu Ser Leu Val Ser Phe Arg 
465                 470                 475                 480 


Ile Pro Tyr Tyr Val Gly Pro Leu Thr Arg Lys Asn Ala Ala Ile Gly 
                485                 490                 495     


His Asp Gly Lys Glu Arg Phe Ala Trp Ser Ser Arg Lys Asp Gly Met 
            500                 505                 510         


Glu His Ala Val Ile Thr Pro Trp Asn Trp Glu Glu Ile Ile Asp Arg 
        515                 520                 525             


Asp Lys Ser Ala Glu Asp Phe Ile Met Arg Met Thr Gly Asp Cys Thr 
    530                 535                 540                 


Tyr Leu Gln Gly Glu Pro Val Leu Pro Lys Cys Ser Leu Leu Tyr Glu 
545                 550                 555                 560 


Glu Phe Cys Ala Leu Asn Glu Phe Asn Gly Ala His Trp Thr Val Asp 
                565                 570                 575     


Gly Asp Asp Glu Arg Arg Phe Asp Ala Ala Gln Arg Glu Arg Ile Met 
            580                 585                 590         


Cys Asp Leu Phe Arg Arg Thr Arg Ser Val Thr Tyr Asn Lys Val Ser 
        595                 600                 605             


Asp Trp Leu Glu Arg Lys Tyr Asn Phe Thr Gly Ala Arg Val Arg Gly 
    610                 615                 620                 


Gly Gln Gly Glu His Gly Phe Glu Ser Lys Leu Gly Ser Tyr Ile Phe 
625                 630                 635                 640 


Phe Cys Lys Asp Val Phe Lys Thr Asp Gly Leu Asp Glu Ala Asp Tyr 
                645                 650                 655     


Thr Met Ile Glu Gln Ile Ile Leu Trp Ser Thr Leu Phe Glu Asp Arg 
            660                 665                 670         


Asp Ile Leu Lys Arg Lys Ile Glu Glu Ala Tyr Gly Gly Asp Arg Leu 
        675                 680                 685             


Thr Ser Glu Gln Ile Lys Val Ile Cys Lys Lys Arg Phe Thr Gly Trp 
    690                 695                 700                 


Gly Arg Leu Ser Lys Arg Leu Leu Thr Asp Ile Lys Val Asn Thr Asp 
705                 710                 715                 720 


Thr Gly Arg Lys Ser Ile Met Asp Val Leu Arg Glu Gly Asn Pro Asn 
                725                 730                 735     


Asn Gly Gln Arg Ser Arg Thr Met Val Phe Met Glu Val Leu Arg Asp 
            740                 745                 750         


Glu Asp Leu Gly Phe Gln Lys Ala Ile Asp Gly Leu Asn Arg Asp Tyr 
        755                 760                 765             


Phe Arg Glu His Asn Asn Gly Leu Met Asp Val Asn Asp Leu Pro Gly 
    770                 775                 780                 


Ser Pro Ala Ile Arg Arg Ser Ile Asn Gln Ala Val Arg Ile Val Asp 
785                 790                 795                 800 


Glu Ile Ala Ser Ile Ala Arg Lys Glu Pro Thr Asn Ile Phe Ile Glu 
                805                 810                 815     


Val Thr Arg Glu Glu Asp Asp Pro Arg Lys Lys Gly Lys Arg Thr Lys 
            820                 825                 830         


Arg Arg Tyr Asp Ala Ile Lys Ser Ala Leu Glu Lys Phe Lys Lys Asp 
        835                 840                 845             


Asp Pro Ser Leu Trp Lys Glu Leu Cys Glu Lys Ala Pro Gly Asp Met 
    850                 855                 860                 


Asp Glu Arg Leu Ser Leu Tyr Phe Met Gln Arg Gly Lys Cys Met Tyr 
865                 870                 875                 880 


Ser Gly Arg Pro Ile Lys Ile Glu Glu Leu His Thr Gly Lys Tyr Glu 
                885                 890                 895     


Val Asp His Ile Ile Pro Arg Ser Tyr Ile Lys Asp Asp Ser Phe Glu 
            900                 905                 910         


Asn Lys Val Leu Val Tyr Arg Glu Glu Asn Gln His Lys Thr Asp Ala 
        915                 920                 925             


Leu Leu Ile Asp Ser Ser Ile Arg Gln Lys Met Gly Gly Tyr Trp Arg 
    930                 935                 940                 


Met Leu His Asp Ala Lys Leu Val Gly Asp Lys Lys Phe Arg Asn Leu 
945                 950                 955                 960 


Phe Arg Asn His Ile Asp Asp Lys Ala Met Lys Gly Phe Val Ala Arg 
                965                 970                 975     


Gln Ile Val Glu Thr Ser Gln Met Val Lys Leu Val Gln Thr Leu Phe 
            980                 985                 990         


Glu Ala Arg Tyr Pro Asn Thr Arg  Ile Val Pro Val Lys  Ala Gly Ile 
        995                 1000                 1005             


Ser His  Asp Leu Arg Glu Ala  Ala Gly Leu Val Lys  Cys Arg Glu 
    1010                 1015                 1020             


Ala Asn  Asp Phe His His Ala  His Asp Ala Phe Leu  Ala Cys Arg 
    1025                 1030                 1035             


Ile Gly  Leu Phe Ile Gln Lys  Arg His Pro Ser Val  Tyr Asp Asn 
    1040                 1045                 1050             


Pro Ile  Gly Leu Ala Arg Ile  Met Arg Asp Tyr Ala  Arg Met Gln 
    1055                 1060                 1065             


Ala Arg  Glu Tyr Lys Lys Ser  His Cys Leu Ala His  Thr Gln Gly 
    1070                 1075                 1080             


Phe Ile  Val Asn Ser Phe Leu  Ser Ser Gly Phe Asp  Glu Glu Thr 
    1085                 1090                 1095             


Gly Glu  Ile Phe Lys Asp Asp  Trp Asp Ala Lys Ala  Glu Val Glu 
    1100                 1105                 1110             


Gly Ile  Arg Arg Val Leu Asn  Cys Arg Gln Cys Phe  Ile Ser Arg 
    1115                 1120                 1125             


Met Pro  Val Glu Gly Asp Thr  Arg Tyr Gly Gly Arg  Tyr Trp Gly 
    1130                 1135                 1140             


Glu Thr  Ile Tyr Ser Pro Lys  Gly Lys His Lys His  Glu Ile Pro 
    1145                 1150                 1155             


Leu Lys  Gln Gly Leu Asp Pro  Asn Leu Tyr Gly Gly  Tyr Ser Asp 
    1160                 1165                 1170             


Leu Leu  Tyr Ser Tyr Phe Leu  Ile Tyr Glu Ala Ser  Asp Val Ser 
    1175                 1180                 1185             


Ser Gly  Glu Arg Val Leu Arg  Phe Ile Gly Ile Pro  Thr Ser Ile 
    1190                 1195                 1200             


Ala Ala  Arg Met Ala Asn Gln  Lys Arg Leu Glu Glu  Tyr Val Ser 
    1205                 1210                 1215             


Arg Leu  Ala Leu Gln Glu Asn  Leu Glu His Val Arg  Met Val Arg 
    1220                 1225                 1230             


Lys Ile  Met Lys Lys Gln Leu  Ile Glu Val Asp Asn  Cys Arg Leu 
    1235                 1240                 1245             


Leu Val  Thr Ala Ala Asp Ala  Val Thr Asn Ala Thr  Glu Leu Ala 
    1250                 1255                 1260             


Phe Ser  Leu Asp Glu Met Lys  Ile Ile Ser Thr Cys  Ala Lys Cys 
    1265                 1270                 1275             


Ile Asn  Gly Ala Asp Pro Ser  Ala Ile Asp Lys Ile  Gly Asn Ala 
    1280                 1285                 1290             


Gln Asp  Ser Phe Phe Asp Asn  Leu Lys Arg Arg Gly  Ser Asp Arg 
    1295                 1300                 1305             


Cys Ala  Leu Leu Phe Ser Gln  Leu Lys Leu Asp Lys  Leu Ser Gln 
    1310                 1315                 1320             


Asn Phe  Tyr Met Ile Ser Ser  Asp Asp Lys Ser Lys  Ile Leu Ile 
    1325                 1330                 1335             


Ser Ile  Leu Asp Arg Ile Arg  Ala Lys Ser Asn Ser  Val Asp Leu 
    1340                 1345                 1350             


Ser Leu  Val Gly Gly Ala Lys  His Ala Ala Gln Met  Lys Phe Asp 
    1355                 1360                 1365             


Phe Asn  Ala Lys Leu Asn Asn  Pro Ala Ser Ser Phe  Val Leu Ile 
    1370                 1375                 1380             


Asp Gln  Ser Val Thr Gly Met  Phe Glu Arg Arg Thr  Arg Ile Gly 
    1385                 1390                 1395             


Leu 
    


<210>  714
<211>  1389
<212>  PRT
<213>  Oenococcus kitaharae DSM 17330

<400>  714

Met Ala Arg Asp Tyr Ser Val Gly Leu Asp Ile Gly Thr Ser Ser Val 
1               5                   10                  15      


Gly Trp Ala Ala Ile Asp Asn Lys Tyr His Leu Ile Arg Ala Lys Ser 
            20                  25                  30          


Lys Asn Leu Ile Gly Val Arg Leu Phe Asp Ser Ala Val Thr Ala Glu 
        35                  40                  45              


Lys Arg Arg Gly Tyr Arg Thr Thr Arg Arg Arg Leu Ser Arg Arg His 
    50                  55                  60                  


Trp Arg Leu Arg Leu Leu Asn Asp Ile Phe Ala Gly Pro Leu Thr Asp 
65                  70                  75                  80  


Phe Gly Asp Glu Asn Phe Leu Ala Arg Leu Lys Tyr Ser Trp Val His 
                85                  90                  95      


Pro Gln Asp Gln Ser Asn Gln Ala His Phe Ala Ala Gly Leu Leu Phe 
            100                 105                 110         


Asp Ser Lys Glu Gln Asp Lys Asp Phe Tyr Arg Lys Tyr Pro Thr Ile 
        115                 120                 125             


Tyr His Leu Arg Leu Ala Leu Met Asn Asp Asp Gln Lys His Asp Leu 
    130                 135                 140                 


Arg Glu Val Tyr Leu Ala Ile His His Leu Val Lys Tyr Arg Gly His 
145                 150                 155                 160 


Phe Leu Ile Glu Gly Asp Val Lys Ala Asp Ser Ala Phe Asp Val His 
                165                 170                 175     


Thr Phe Ala Asp Ala Ile Gln Arg Tyr Ala Glu Ser Asn Asn Ser Asp 
            180                 185                 190         


Glu Asn Leu Leu Gly Lys Ile Asp Glu Lys Lys Leu Ser Ala Ala Leu 
        195                 200                 205             


Thr Asp Lys His Gly Ser Lys Ser Gln Arg Ala Glu Thr Ala Glu Thr 
    210                 215                 220                 


Ala Phe Asp Ile Leu Asp Leu Gln Ser Lys Lys Gln Ile Gln Ala Ile 
225                 230                 235                 240 


Leu Lys Ser Val Val Gly Asn Gln Ala Asn Leu Met Ala Ile Phe Gly 
                245                 250                 255     


Leu Asp Ser Ser Ala Ile Ser Lys Asp Glu Gln Lys Asn Tyr Lys Phe 
            260                 265                 270         


Ser Phe Asp Asp Ala Asp Ile Asp Glu Lys Ile Ala Asp Ser Glu Ala 
        275                 280                 285             


Leu Leu Ser Asp Thr Glu Phe Glu Phe Leu Cys Asp Leu Lys Ala Ala 
    290                 295                 300                 


Phe Asp Gly Leu Thr Leu Lys Met Leu Leu Gly Asp Asp Lys Thr Val 
305                 310                 315                 320 


Ser Ala Ala Met Val Arg Arg Phe Asn Glu His Gln Lys Asp Trp Glu 
                325                 330                 335     


Tyr Ile Lys Ser His Ile Arg Asn Ala Lys Asn Ala Gly Asn Gly Leu 
            340                 345                 350         


Tyr Glu Lys Ser Lys Lys Phe Asp Gly Ile Asn Ala Ala Tyr Leu Ala 
        355                 360                 365             


Leu Gln Ser Asp Asn Glu Asp Asp Arg Lys Lys Ala Lys Lys Ile Phe 
    370                 375                 380                 


Gln Asp Glu Ile Ser Ser Ala Asp Ile Pro Asp Asp Val Lys Ala Asp 
385                 390                 395                 400 


Phe Leu Lys Lys Ile Asp Asp Asp Gln Phe Leu Pro Ile Gln Arg Thr 
                405                 410                 415     


Lys Asn Asn Gly Thr Ile Pro His Gln Leu His Arg Asn Glu Leu Glu 
            420                 425                 430         


Gln Ile Ile Glu Lys Gln Gly Ile Tyr Tyr Pro Phe Leu Lys Asp Thr 
        435                 440                 445             


Tyr Gln Glu Asn Ser His Glu Leu Asn Lys Ile Thr Ala Leu Ile Asn 
    450                 455                 460                 


Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu Val Glu Glu Glu Gln Lys 
465                 470                 475                 480 


Ile Ala Asp Asp Gly Lys Asn Ile Pro Asp Pro Thr Asn His Trp Met 
                485                 490                 495     


Val Arg Lys Ser Asn Asp Thr Ile Thr Pro Trp Asn Leu Ser Gln Val 
            500                 505                 510         


Val Asp Leu Asp Lys Ser Gly Arg Arg Phe Ile Glu Arg Leu Thr Gly 
        515                 520                 525             


Thr Asp Thr Tyr Leu Ile Gly Glu Pro Thr Leu Pro Lys Asn Ser Leu 
    530                 535                 540                 


Leu Tyr Gln Lys Phe Asp Val Leu Gln Glu Leu Asn Asn Ile Arg Val 
545                 550                 555                 560 


Ser Gly Arg Arg Leu Asp Ile Arg Ala Lys Gln Asp Ala Phe Glu His 
                565                 570                 575     


Leu Phe Lys Val Gln Lys Thr Val Ser Ala Thr Asn Leu Lys Asp Phe 
            580                 585                 590         


Leu Val Gln Ala Gly Tyr Ile Ser Glu Asp Thr Gln Ile Glu Gly Leu 
        595                 600                 605             


Ala Asp Val Asn Gly Lys Asn Phe Asn Asn Ala Leu Thr Thr Tyr Asn 
    610                 615                 620                 


Tyr Leu Val Ser Val Leu Gly Arg Glu Phe Val Glu Asn Pro Ser Asn 
625                 630                 635                 640 


Glu Glu Leu Leu Glu Glu Ile Thr Glu Leu Gln Thr Val Phe Glu Asp 
                645                 650                 655     


Lys Lys Val Leu Arg Arg Gln Leu Asp Gln Leu Asp Gly Leu Ser Asp 
            660                 665                 670         


His Asn Arg Glu Lys Leu Ser Arg Lys His Tyr Thr Gly Trp Gly Arg 
        675                 680                 685             


Ile Ser Lys Lys Leu Leu Thr Thr Lys Ile Val Gln Asn Ala Asp Lys 
    690                 695                 700                 


Ile Asp Asn Gln Thr Phe Asp Val Pro Arg Met Asn Gln Ser Ile Ile 
705                 710                 715                 720 


Asp Thr Leu Tyr Asn Thr Lys Met Asn Leu Met Glu Ile Ile Asn Asn 
                725                 730                 735     


Ala Glu Asp Asp Phe Gly Val Arg Ala Trp Ile Asp Lys Gln Asn Thr 
            740                 745                 750         


Thr Asp Gly Asp Glu Gln Asp Val Tyr Ser Leu Ile Asp Glu Leu Ala 
        755                 760                 765             


Gly Pro Lys Glu Ile Lys Arg Gly Ile Val Gln Ser Phe Arg Ile Leu 
    770                 775                 780                 


Asp Asp Ile Thr Lys Ala Val Gly Tyr Ala Pro Lys Arg Val Tyr Leu 
785                 790                 795                 800 


Glu Phe Ala Arg Lys Thr Gln Glu Ser His Leu Thr Asn Ser Arg Lys 
                805                 810                 815     


Asn Gln Leu Ser Thr Leu Leu Lys Asn Ala Gly Leu Ser Glu Leu Val 
            820                 825                 830         


Thr Gln Val Ser Gln Tyr Asp Ala Ala Ala Leu Gln Asn Asp Arg Leu 
        835                 840                 845             


Tyr Leu Tyr Phe Leu Gln Gln Gly Lys Asp Met Tyr Ser Gly Glu Lys 
    850                 855                 860                 


Leu Asn Leu Asp Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Ile Pro 
865                 870                 875                 880 


Gln Ala Tyr Thr Lys Asp Asn Ser Leu Asp Asn Arg Val Leu Val Ser 
                885                 890                 895     


Asn Ile Thr Asn Arg Arg Lys Ser Asp Ser Ser Asn Tyr Leu Pro Ala 
            900                 905                 910         


Leu Ile Asp Lys Met Arg Pro Phe Trp Ser Val Leu Ser Lys Gln Gly 
        915                 920                 925             


Leu Leu Ser Lys His Lys Phe Ala Asn Leu Thr Arg Thr Arg Asp Phe 
    930                 935                 940                 


Asp Asp Met Glu Lys Glu Arg Phe Ile Ala Arg Ser Leu Val Glu Thr 
945                 950                 955                 960 


Arg Gln Ile Ile Lys Asn Val Ala Ser Leu Ile Asp Ser His Phe Gly 
                965                 970                 975     


Gly Glu Thr Lys Ala Val Ala Ile Arg Ser Ser Leu Thr Ala Asp Met 
            980                 985                 990         


Arg Arg Tyr Val Asp Ile Pro Lys  Asn Arg Asp Ile Asn  Asp Tyr His 
        995                 1000                 1005             


His Ala  Phe Asp Ala Leu Leu  Phe Ser Thr Val Gly  Gln Tyr Thr 
    1010                 1015                 1020             


Glu Asn  Ser Gly Leu Met Lys  Lys Gly Gln Leu Ser  Asp Ser Ala 
    1025                 1030                 1035             


Gly Asn  Gln Tyr Asn Arg Tyr  Ile Lys Glu Trp Ile  His Ala Ala 
    1040                 1045                 1050             


Arg Leu  Asn Ala Gln Ser Gln  Arg Val Asn Pro Phe  Gly Phe Val 
    1055                 1060                 1065             


Val Gly  Ser Met Arg Asn Ala  Ala Pro Gly Lys Leu  Asn Pro Glu 
    1070                 1075                 1080             


Thr Gly  Glu Ile Thr Pro Glu  Glu Asn Ala Asp Trp  Ser Ile Ala 
    1085                 1090                 1095             


Asp Leu  Asp Tyr Leu His Lys  Val Met Asn Phe Arg  Lys Ile Thr 
    1100                 1105                 1110             


Val Thr  Arg Arg Leu Lys Asp  Gln Lys Gly Gln Leu  Tyr Asp Glu 
    1115                 1120                 1125             


Ser Arg  Tyr Pro Ser Val Leu  His Asp Ala Lys Ser  Lys Ala Ser 
    1130                 1135                 1140             


Ile Asn  Phe Asp Lys His Lys  Pro Val Asp Leu Tyr  Gly Gly Phe 
    1145                 1150                 1155             


Ser Ser  Ala Lys Pro Ala Tyr  Ala Ala Leu Ile Lys  Phe Lys Asn 
    1160                 1165                 1170             


Lys Phe  Arg Leu Val Asn Val  Leu Arg Gln Trp Thr  Tyr Ser Asp 
    1175                 1180                 1185             


Lys Asn  Ser Glu Asp Tyr Ile  Leu Glu Gln Ile Arg  Gly Lys Tyr 
    1190                 1195                 1200             


Pro Lys  Ala Glu Met Val Leu  Ser His Ile Pro Tyr  Gly Gln Leu 
    1205                 1210                 1215             


Val Lys  Lys Asp Gly Ala Leu  Val Thr Ile Ser Ser  Ala Thr Glu 
    1220                 1225                 1230             


Leu His  Asn Phe Glu Gln Leu  Trp Leu Pro Leu Ala  Asp Tyr Lys 
    1235                 1240                 1245             


Leu Ile  Asn Thr Leu Leu Lys  Thr Lys Glu Asp Asn  Leu Val Asp 
    1250                 1255                 1260             


Ile Leu  His Asn Arg Leu Asp  Leu Pro Glu Met Thr  Ile Glu Ser 
    1265                 1270                 1275             


Ala Phe  Tyr Lys Ala Phe Asp  Ser Ile Leu Ser Phe  Ala Phe Asn 
    1280                 1285                 1290             


Arg Tyr  Ala Leu His Gln Asn  Ala Leu Val Lys Leu  Gln Ala His 
    1295                 1300                 1305             


Arg Asp  Asp Phe Asn Ala Leu  Asn Tyr Glu Asp Lys  Gln Gln Thr 
    1310                 1315                 1320             


Leu Glu  Arg Ile Leu Asp Ala  Leu His Ala Ser Pro  Ala Ser Ser 
    1325                 1330                 1335             


Asp Leu  Lys Lys Ile Asn Leu  Ser Ser Gly Phe Gly  Arg Leu Phe 
    1340                 1345                 1350             


Ser Pro  Ser His Phe Thr Leu  Ala Asp Thr Asp Glu  Phe Ile Phe 
    1355                 1360                 1365             


Gln Ser  Val Thr Gly Leu Phe  Ser Thr Gln Lys Thr  Val Ala Gln 
    1370                 1375                 1380             


Leu Tyr  Gln Glu Thr Lys 
    1385                 


<210>  715
<211>  1420
<212>  PRT
<213>  Bifidobacterium bifidum S17

<400>  715

Met Ser Arg Lys Asn Tyr Val Asp Asp Tyr Ala Ile Ser Leu Asp Ile 
1               5                   10                  15      


Gly Asn Ala Ser Val Gly Trp Ser Ala Phe Thr Pro Asn Tyr Arg Leu 
            20                  25                  30          


Val Arg Ala Lys Gly His Glu Leu Ile Gly Val Arg Leu Phe Asp Pro 
        35                  40                  45              


Ala Asp Thr Ala Glu Ser Arg Arg Met Ala Arg Thr Thr Arg Arg Arg 
    50                  55                  60                  


Tyr Ser Arg Arg Arg Trp Arg Leu Arg Leu Leu Asp Ala Leu Phe Asp 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Ile Asp Pro Ser Phe Leu Ala Arg Arg Lys Tyr 
                85                  90                  95      


Ser Trp Val His Pro Asp Asp Glu Asn Asn Ala Asp Cys Trp Tyr Gly 
            100                 105                 110         


Ser Val Leu Phe Asp Ser Asn Glu Gln Asp Lys Arg Phe Tyr Glu Lys 
        115                 120                 125             


Tyr Pro Thr Ile Tyr His Leu Arg Lys Ala Leu Met Glu Asp Asp Ser 
    130                 135                 140                 


Gln His Asp Ile Arg Glu Ile Tyr Leu Ala Ile His His Met Val Lys 
145                 150                 155                 160 


Tyr Arg Gly Asn Phe Leu Val Glu Gly Thr Leu Glu Ser Ser Asn Ala 
                165                 170                 175     


Phe Lys Glu Asp Glu Leu Leu Lys Leu Leu Gly Arg Ile Thr Arg Tyr 
            180                 185                 190         


Glu Met Ser Glu Gly Glu Gln Asn Ser Asp Ile Glu Gln Asp Asp Glu 
        195                 200                 205             


Asn Lys Leu Val Ala Pro Ala Asn Gly Gln Leu Ala Asp Ala Leu Cys 
    210                 215                 220                 


Ala Thr Arg Gly Ser Arg Ser Met Arg Val Asp Asn Ala Leu Glu Ala 
225                 230                 235                 240 


Leu Ser Ala Val Asn Asp Leu Ser Arg Glu Gln Arg Ala Ile Val Lys 
                245                 250                 255     


Ala Ile Phe Ala Gly Leu Glu Gly Asn Lys Leu Asp Leu Ala Lys Ile 
            260                 265                 270         


Phe Val Ser Lys Glu Phe Ser Ser Glu Asn Lys Lys Ile Leu Gly Ile 
        275                 280                 285             


Tyr Phe Asn Lys Ser Asp Tyr Glu Glu Lys Cys Val Gln Ile Val Asp 
    290                 295                 300                 


Ser Gly Leu Leu Asp Asp Glu Glu Arg Glu Phe Leu Asp Arg Met Gln 
305                 310                 315                 320 


Gly Gln Tyr Asn Ala Ile Ala Leu Lys Gln Leu Leu Gly Arg Ser Thr 
                325                 330                 335     


Ser Val Ser Asp Ser Lys Cys Ala Ser Tyr Asp Ala His Arg Ala Asn 
            340                 345                 350         


Trp Asn Leu Ile Lys Leu Gln Leu Arg Thr Lys Glu Asn Glu Lys Asp 
        355                 360                 365             


Ile Asn Glu Asn Tyr Gly Ile Leu Val Gly Trp Lys Ile Asp Ser Gly 
    370                 375                 380                 


Gln Arg Lys Ser Val Arg Gly Glu Ser Ala Tyr Glu Asn Met Arg Lys 
385                 390                 395                 400 


Lys Ala Asn Val Phe Phe Lys Lys Met Ile Glu Thr Ser Asp Leu Ser 
                405                 410                 415     


Glu Thr Asp Lys Asn Arg Leu Ile His Asp Ile Glu Glu Asp Lys Leu 
            420                 425                 430         


Phe Pro Ile Gln Arg Asp Ser Asp Asn Gly Val Ile Pro His Gln Leu 
        435                 440                 445             


His Gln Asn Glu Leu Lys Gln Ile Ile Lys Lys Gln Gly Lys Tyr Tyr 
    450                 455                 460                 


Pro Phe Leu Leu Asp Ala Phe Glu Lys Asp Gly Lys Gln Ile Asn Lys 
465                 470                 475                 480 


Ile Glu Gly Leu Leu Thr Phe Arg Val Pro Tyr Phe Val Gly Pro Leu 
                485                 490                 495     


Val Val Pro Glu Asp Leu Gln Lys Ser Asp Asn Ser Glu Asn His Trp 
            500                 505                 510         


Met Val Arg Lys Lys Lys Gly Glu Ile Thr Pro Trp Asn Phe Asp Glu 
        515                 520                 525             


Met Val Asp Lys Asp Ala Ser Gly Arg Lys Phe Ile Glu Arg Leu Val 
    530                 535                 540                 


Gly Thr Asp Ser Tyr Leu Leu Gly Glu Pro Thr Leu Pro Lys Asn Ser 
545                 550                 555                 560 


Leu Leu Tyr Gln Glu Tyr Glu Val Leu Asn Glu Leu Asn Asn Val Arg 
                565                 570                 575     


Leu Ser Val Arg Thr Gly Asn His Trp Asn Asp Lys Arg Arg Met Arg 
            580                 585                 590         


Leu Gly Arg Glu Glu Lys Thr Leu Leu Cys Gln Arg Leu Phe Met Lys 
        595                 600                 605             


Gly Gln Thr Val Thr Lys Arg Thr Ala Glu Asn Leu Leu Arg Lys Glu 
    610                 615                 620                 


Tyr Gly Arg Thr Tyr Glu Leu Ser Gly Leu Ser Asp Glu Ser Lys Phe 
625                 630                 635                 640 


Thr Ser Ser Leu Ser Thr Tyr Gly Lys Met Cys Arg Ile Phe Gly Glu 
                645                 650                 655     


Lys Tyr Val Asn Glu His Arg Asp Leu Met Glu Lys Ile Val Glu Leu 
            660                 665                 670         


Gln Thr Val Phe Glu Asp Lys Glu Thr Leu Leu His Gln Leu Arg Gln 
        675                 680                 685             


Leu Glu Gly Ile Ser Glu Ala Asp Cys Ala Leu Leu Val Asn Thr His 
    690                 695                 700                 


Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Leu Thr Thr Lys Ala 
705                 710                 715                 720 


Gly Glu Cys Lys Ile Ser Asp Asp Phe Ala Pro Arg Lys His Ser Ile 
                725                 730                 735     


Ile Glu Ile Met Arg Ala Glu Asp Arg Asn Leu Met Glu Ile Ile Thr 
            740                 745                 750         


Asp Lys Gln Leu Gly Phe Ser Asp Trp Ile Glu Gln Glu Asn Leu Gly 
        755                 760                 765             


Ala Glu Asn Gly Ser Ser Leu Met Glu Val Val Asp Asp Leu Arg Val 
    770                 775                 780                 


Ser Pro Lys Val Lys Arg Gly Ile Ile Gln Ser Ile Arg Leu Ile Asp 
785                 790                 795                 800 


Asp Ile Ser Lys Ala Val Gly Lys Arg Pro Ser Arg Ile Phe Leu Glu 
                805                 810                 815     


Leu Ala Asp Asp Ile Gln Pro Ser Gly Arg Thr Ile Ser Arg Lys Ser 
            820                 825                 830         


Arg Leu Gln Asp Leu Tyr Arg Asn Ala Asn Leu Gly Lys Glu Phe Lys 
        835                 840                 845             


Gly Ile Ala Asp Glu Leu Asn Ala Cys Ser Asp Lys Asp Leu Gln Asp 
    850                 855                 860                 


Asp Arg Leu Phe Leu Tyr Tyr Thr Gln Leu Gly Lys Asp Met Tyr Thr 
865                 870                 875                 880 


Gly Glu Glu Leu Asp Leu Asp Arg Leu Ser Ser Ala Tyr Asp Ile Asp 
                885                 890                 895     


His Ile Ile Pro Gln Ala Val Thr Gln Asn Asp Ser Ile Asp Asn Arg 
            900                 905                 910         


Val Leu Val Ala Arg Ala Glu Asn Ala Arg Lys Thr Asp Ser Phe Thr 
        915                 920                 925             


Tyr Met Pro Gln Ile Ala Asp Arg Met Arg Asn Phe Trp Gln Ile Leu 
    930                 935                 940                 


Leu Asp Asn Gly Leu Ile Ser Arg Val Lys Phe Glu Arg Leu Thr Arg 
945                 950                 955                 960 


Gln Asn Glu Phe Ser Glu Arg Glu Lys Glu Arg Phe Val Gln Arg Ser 
                965                 970                 975     


Leu Val Glu Thr Arg Gln Ile Met Lys Asn Val Ala Thr Leu Met Arg 
            980                 985                 990         


Gln Arg Tyr Gly Asn Ser Ala Ala  Val Ile Gly Leu Asn  Ala Glu Leu 
        995                 1000                 1005             


Thr Lys  Glu Met His Arg Tyr  Leu Gly Phe Ser His  Lys Asn Arg 
    1010                 1015                 1020             


Asp Ile  Asn Asp Tyr His His  Ala Gln Asp Ala Leu  Cys Val Gly 
    1025                 1030                 1035             


Ile Ala  Gly Gln Phe Ala Ala  Asn Arg Gly Phe Phe  Ala Asp Gly 
    1040                 1045                 1050             


Glu Val  Ser Asp Gly Ala Gln  Asn Ser Tyr Asn Gln  Tyr Leu Arg 
    1055                 1060                 1065             


Asp Tyr  Leu Arg Gly Tyr Arg  Glu Lys Leu Ser Ala  Glu Asp Arg 
    1070                 1075                 1080             


Lys Gln  Gly Arg Ala Phe Gly  Phe Ile Val Gly Ser  Met Arg Ser 
    1085                 1090                 1095             


Gln Asp  Glu Gln Lys Arg Val  Asn Pro Arg Thr Gly  Glu Val Val 
    1100                 1105                 1110             


Trp Ser  Glu Glu Asp Lys Asp  Tyr Leu Arg Lys Val  Met Asn Tyr 
    1115                 1120                 1125             


Arg Lys  Met Leu Val Thr Gln  Lys Val Gly Asp Asp  Phe Gly Ala 
    1130                 1135                 1140             


Leu Tyr  Asp Glu Thr Arg Tyr  Ala Ala Thr Asp Pro  Lys Gly Ile 
    1145                 1150                 1155             


Lys Gly  Ile Pro Phe Asp Gly  Ala Lys Gln Asp Thr  Ser Leu Tyr 
    1160                 1165                 1170             


Gly Gly  Phe Ser Ser Ala Lys  Pro Ala Tyr Ala Val  Leu Ile Glu 
    1175                 1180                 1185             


Ser Lys  Gly Lys Thr Arg Leu  Val Asn Val Thr Met  Gln Glu Tyr 
    1190                 1195                 1200             


Ser Leu  Leu Gly Asp Arg Pro  Ser Asp Asp Glu Leu  Arg Lys Val 
    1205                 1210                 1215             


Leu Ala  Lys Lys Lys Ser Glu  Tyr Ala Lys Ala Asn  Ile Leu Leu 
    1220                 1225                 1230             


Arg His  Val Pro Lys Met Gln  Leu Ile Arg Tyr Gly  Gly Gly Leu 
    1235                 1240                 1245             


Met Val  Ile Lys Ser Ala Gly  Glu Leu Asn Asn Ala  Gln Gln Leu 
    1250                 1255                 1260             


Trp Leu  Pro Tyr Glu Glu Tyr  Cys Tyr Phe Asp Asp  Leu Ser Gln 
    1265                 1270                 1275             


Gly Lys  Gly Ser Leu Glu Lys  Asp Asp Leu Lys Lys  Leu Leu Asp 
    1280                 1285                 1290             


Ser Ile  Leu Gly Ser Val Gln  Cys Leu Tyr Pro Trp  His Arg Phe 
    1295                 1300                 1305             


Thr Glu  Glu Glu Leu Ala Asp  Leu His Val Ala Phe  Asp Lys Leu 
    1310                 1315                 1320             


Pro Glu  Asp Glu Lys Lys Asn  Val Ile Thr Gly Ile  Val Ser Ala 
    1325                 1330                 1335             


Leu His  Ala Asp Ala Lys Thr  Ala Asn Leu Ser Ile  Val Gly Met 
    1340                 1345                 1350             


Thr Gly  Ser Trp Arg Arg Met  Asn Asn Lys Ser Gly  Tyr Thr Phe 
    1355                 1360                 1365             


Ser Asp  Glu Asp Glu Phe Ile  Phe Gln Ser Pro Ser  Gly Leu Phe 
    1370                 1375                 1380             


Glu Lys  Arg Val Thr Val Gly  Glu Leu Lys Arg Lys  Ala Lys Lys 
    1385                 1390                 1395             


Glu Val  Asn Ser Lys Tyr Arg  Thr Asn Glu Lys Arg  Leu Pro Thr 
    1400                 1405                 1410             


Leu Ser  Gly Ala Ser Gln Pro  
    1415                 1420 


<210>  716
<211>  1363
<212>  PRT
<213>  Lactobacillus rhamnosus GG

<400>  716

Met Thr Lys Leu Asn Gln Pro Tyr Gly Ile Gly Leu Asp Ile Gly Ser 
1               5                   10                  15      


Asn Ser Ile Gly Phe Ala Val Val Asp Ala Asn Ser His Leu Leu Arg 
            20                  25                  30          


Leu Lys Gly Glu Thr Ala Ile Gly Ala Arg Leu Phe Arg Glu Gly Gln 
        35                  40                  45              


Ser Ala Ala Asp Arg Arg Gly Ser Arg Thr Thr Arg Arg Arg Leu Ser 
    50                  55                  60                  


Arg Thr Arg Trp Arg Leu Ser Phe Leu Arg Asp Phe Phe Ala Pro His 
65                  70                  75                  80  


Ile Thr Lys Ile Asp Pro Asp Phe Phe Leu Arg Gln Lys Tyr Ser Glu 
                85                  90                  95      


Ile Ser Pro Lys Asp Lys Asp Arg Phe Lys Tyr Glu Lys Arg Leu Phe 
            100                 105                 110         


Asn Asp Arg Thr Asp Ala Glu Phe Tyr Glu Asp Tyr Pro Ser Met Tyr 
        115                 120                 125             


His Leu Arg Leu His Leu Met Thr His Thr His Lys Ala Asp Pro Arg 
    130                 135                 140                 


Glu Ile Phe Leu Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 
145                 150                 155                 160 


Leu Thr Pro Gly Ala Ala Lys Asp Phe Asn Thr Asp Lys Val Asp Leu 
                165                 170                 175     


Glu Asp Ile Phe Pro Ala Leu Thr Glu Ala Tyr Ala Gln Val Tyr Pro 
            180                 185                 190         


Asp Leu Glu Leu Thr Phe Asp Leu Ala Lys Ala Asp Asp Phe Lys Ala 
        195                 200                 205             


Lys Leu Leu Asp Glu Gln Ala Thr Pro Ser Asp Thr Gln Lys Ala Leu 
    210                 215                 220                 


Val Asn Leu Leu Leu Ser Ser Asp Gly Glu Lys Glu Ile Val Lys Lys 
225                 230                 235                 240 


Arg Lys Gln Val Leu Thr Glu Phe Ala Lys Ala Ile Thr Gly Leu Lys 
                245                 250                 255     


Thr Lys Phe Asn Leu Ala Leu Gly Thr Glu Val Asp Glu Ala Asp Ala 
            260                 265                 270         


Ser Asn Trp Gln Phe Ser Met Gly Gln Leu Asp Asp Lys Trp Ser Asn 
        275                 280                 285             


Ile Glu Thr Ser Met Thr Asp Gln Gly Thr Glu Ile Phe Glu Gln Ile 
    290                 295                 300                 


Gln Glu Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 
305                 310                 315                 320 


Met Ser Leu Ser Gln Ala Lys Val Ala Asp Tyr Gly Gln His Lys Glu 
                325                 330                 335     


Asp Leu Glu Leu Phe Lys Thr Tyr Leu Lys Lys Leu Asn Asp His Glu 
            340                 345                 350         


Leu Ala Lys Thr Ile Arg Gly Leu Tyr Asp Arg Tyr Ile Asn Gly Asp 
        355                 360                 365             


Asp Ala Lys Pro Phe Leu Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 
    370                 375                 380                 


Glu Val Thr Ala His Pro Asn Glu Val Ser Glu Gln Leu Leu Asn Arg 
385                 390                 395                 400 


Met Gly Gln Ala Asn Phe Met Leu Lys Gln Arg Thr Lys Ala Asn Gly 
                405                 410                 415     


Ala Ile Pro Ile Gln Leu Gln Gln Arg Glu Leu Asp Gln Ile Ile Ala 
            420                 425                 430         


Asn Gln Ser Lys Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 
        435                 440                 445             


Ala His Arg Trp Lys Met Pro Tyr Gln Leu Asp Glu Leu Leu Asn Phe 
    450                 455                 460                 


His Ile Pro Tyr Tyr Val Gly Pro Leu Ile Thr Pro Lys Gln Gln Ala 
465                 470                 475                 480 


Glu Ser Gly Glu Asn Val Phe Ala Trp Met Val Arg Lys Asp Pro Ser 
                485                 490                 495     


Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala 
            500                 505                 510         


Ser Ala Asn Thr Phe Ile Gln Arg Met Lys Thr Thr Asp Thr Tyr Leu 
        515                 520                 525             


Ile Gly Glu Asp Val Leu Pro Lys Gln Ser Leu Leu Tyr Gln Lys Tyr 
    530                 535                 540                 


Glu Val Leu Asn Glu Leu Asn Asn Val Arg Ile Asn Asn Glu Cys Leu 
545                 550                 555                 560 


Gly Thr Asp Gln Lys Gln Arg Leu Ile Arg Glu Val Phe Glu Arg His 
                565                 570                 575     


Ser Ser Val Thr Ile Lys Gln Val Ala Asp Asn Leu Val Ala His Gly 
            580                 585                 590         


Asp Phe Ala Arg Arg Pro Glu Ile Arg Gly Leu Ala Asp Glu Lys Arg 
        595                 600                 605             


Phe Leu Ser Ser Leu Ser Thr Tyr His Gln Leu Lys Glu Ile Leu His 
    610                 615                 620                 


Glu Ala Ile Asp Asp Pro Thr Lys Leu Leu Asp Ile Glu Asn Ile Ile 
625                 630                 635                 640 


Thr Trp Ser Thr Val Phe Glu Asp His Thr Ile Phe Glu Thr Lys Leu 
                645                 650                 655     


Ala Glu Ile Glu Trp Leu Asp Pro Lys Lys Ile Asn Glu Leu Ser Gly 
            660                 665                 670         


Ile Arg Tyr Arg Gly Trp Gly Gln Phe Ser Arg Lys Leu Leu Asp Gly 
        675                 680                 685             


Leu Lys Leu Gly Asn Gly His Thr Val Ile Gln Glu Leu Met Leu Ser 
    690                 695                 700                 


Asn His Asn Leu Met Gln Ile Leu Ala Asp Glu Thr Leu Lys Glu Thr 
705                 710                 715                 720 


Met Thr Glu Leu Asn Gln Asp Lys Leu Lys Thr Asp Asp Ile Glu Asp 
                725                 730                 735     


Val Ile Asn Asp Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 
            740                 745                 750         


Gln Val Leu Arg Val Val Glu Asp Ile Lys His Ala Ala Asn Gly Gln 
        755                 760                 765             


Asp Pro Ser Trp Leu Phe Ile Glu Thr Ala Asp Gly Thr Gly Thr Ala 
    770                 775                 780                 


Gly Lys Arg Thr Gln Ser Arg Gln Lys Gln Ile Gln Thr Val Tyr Ala 
785                 790                 795                 800 


Asn Ala Ala Gln Glu Leu Ile Asp Ser Ala Val Arg Gly Glu Leu Glu 
                805                 810                 815     


Asp Lys Ile Ala Asp Lys Ala Ser Phe Thr Asp Arg Leu Val Leu Tyr 
            820                 825                 830         


Phe Met Gln Gly Gly Arg Asp Ile Tyr Thr Gly Ala Pro Leu Asn Ile 
        835                 840                 845             


Asp Gln Leu Ser His Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Leu 
    850                 855                 860                 


Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Val Asn Ala Thr Ile 
865                 870                 875                 880 


Asn Arg Glu Lys Asn Asn Val Phe Ala Ser Thr Leu Phe Ala Gly Lys 
                885                 890                 895     


Met Lys Ala Thr Trp Arg Lys Trp His Glu Ala Gly Leu Ile Ser Gly 
            900                 905                 910         


Arg Lys Leu Arg Asn Leu Met Leu Arg Pro Asp Glu Ile Asp Lys Phe 
        915                 920                 925             


Ala Lys Gly Phe Val Ala Arg Gln Leu Val Glu Thr Arg Gln Ile Ile 
    930                 935                 940                 


Lys Leu Thr Glu Gln Ile Ala Ala Ala Gln Tyr Pro Asn Thr Lys Ile 
945                 950                 955                 960 


Ile Ala Val Lys Ala Gly Leu Ser His Gln Leu Arg Glu Glu Leu Asp 
                965                 970                 975     


Phe Pro Lys Asn Arg Asp Val Asn His Tyr His His Ala Phe Asp Ala 
            980                 985                 990         


Phe Leu Ala Ala Arg Ile Gly Thr  Tyr Leu Leu Lys Arg  Tyr Pro Lys 
        995                 1000                 1005             


Leu Ala  Pro Phe Phe Thr Tyr  Gly Glu Phe Ala Lys  Val Asp Val 
    1010                 1015                 1020             


Lys Lys  Phe Arg Glu Phe Asn  Phe Ile Gly Ala Leu  Thr His Ala 
    1025                 1030                 1035             


Lys Lys  Asn Ile Ile Ala Lys  Asp Thr Gly Glu Ile  Val Trp Asp 
    1040                 1045                 1050             


Lys Glu  Arg Asp Ile Arg Glu  Leu Asp Arg Ile Tyr  Asn Phe Lys 
    1055                 1060                 1065             


Arg Met  Leu Ile Thr His Glu  Val Tyr Phe Glu Thr  Ala Asp Leu 
    1070                 1075                 1080             


Phe Lys  Gln Thr Ile Tyr Ala  Ala Lys Asp Ser Lys  Glu Arg Gly 
    1085                 1090                 1095             


Gly Ser  Lys Gln Leu Ile Pro  Lys Lys Gln Gly Tyr  Pro Thr Gln 
    1100                 1105                 1110             


Val Tyr  Gly Gly Tyr Thr Gln  Glu Ser Gly Ser Tyr  Asn Ala Leu 
    1115                 1120                 1125             


Val Arg  Val Ala Glu Ala Asp  Thr Thr Ala Tyr Gln  Val Ile Lys 
    1130                 1135                 1140             


Ile Ser  Ala Gln Asn Ala Ser  Lys Ile Ala Ser Ala  Asn Leu Lys 
    1145                 1150                 1155             


Ser Arg  Glu Lys Gly Lys Gln  Leu Leu Asn Glu Ile  Val Val Lys 
    1160                 1165                 1170             


Gln Leu  Ala Lys Arg Arg Lys  Asn Trp Lys Pro Ser  Ala Asn Ser 
    1175                 1180                 1185             


Phe Lys  Ile Val Ile Pro Arg  Phe Gly Met Gly Thr  Leu Phe Gln 
    1190                 1195                 1200             


Asn Ala  Lys Tyr Gly Leu Phe  Met Val Asn Ser Asp  Thr Tyr Tyr 
    1205                 1210                 1215             


Arg Asn  Tyr Gln Glu Leu Trp  Leu Ser Arg Glu Asn  Gln Lys Leu 
    1220                 1225                 1230             


Leu Lys  Lys Leu Phe Ser Ile  Lys Tyr Glu Lys Thr  Gln Met Asn 
    1235                 1240                 1245             


His Asp  Ala Leu Gln Val Tyr  Lys Ala Ile Ile Asp  Gln Val Glu 
    1250                 1255                 1260             


Lys Phe  Phe Lys Leu Tyr Asp  Ile Asn Gln Phe Arg  Ala Lys Leu 
    1265                 1270                 1275             


Ser Asp  Ala Ile Glu Arg Phe  Glu Lys Leu Pro Ile  Asn Thr Asp 
    1280                 1285                 1290             


Gly Asn  Lys Ile Gly Lys Thr  Glu Thr Leu Arg Gln  Ile Leu Ile 
    1295                 1300                 1305             


Gly Leu  Gln Ala Asn Gly Thr  Arg Ser Asn Val Lys  Asn Leu Gly 
    1310                 1315                 1320             


Ile Lys  Thr Asp Leu Gly Leu  Leu Gln Val Gly Ser  Gly Ile Lys 
    1325                 1330                 1335             


Leu Asp  Lys Asp Thr Gln Ile  Val Tyr Gln Ser Pro  Ser Gly Leu 
    1340                 1345                 1350             


Phe Lys  Arg Arg Ile Pro Leu  Ala Asp Leu 
    1355                 1360             


<210>  717
<211>  1391
<212>  PRT
<213>  Lactobacillus gasseri JV-V03

<400>  717

Met Thr Lys Ile Lys Asn Glu Tyr Ile Val Gly Leu Asp Val Gly Thr 
1               5                   10                  15      


Asn Ser Cys Gly Trp Val Ala Met Asp Phe Gln Asn Thr Ile Leu Arg 
            20                  25                  30          


Met His Gly Lys Thr Ala Ile Gly Ser His Leu Phe Asp Ala Gly Asn 
        35                  40                  45              


Ser Ala Ala Asp Arg Arg Ala Phe Arg Thr Thr Arg Arg Arg Ile Lys 
    50                  55                  60                  


Arg Arg Lys Trp Arg Leu Lys Leu Leu Glu Glu Ile Phe Asp Pro Tyr 
65                  70                  75                  80  


Met Thr Glu Val Asp Pro Tyr Phe Phe Ala Arg Leu Lys Glu Ser Gly 
                85                  90                  95      


Leu Ser Pro Leu Asp Lys Arg Lys Asn Val Ser Ser Ile Val Phe Pro 
            100                 105                 110         


Thr Ala Leu Glu Asp Lys Lys Phe Tyr Cys Asn Tyr Pro Thr Ile Tyr 
        115                 120                 125             


His Leu Arg Tyr Asp Leu Met Ser Glu Asp Lys Lys Phe Asp Leu Arg 
    130                 135                 140                 


Glu Ile Tyr Leu Ala Ile His His Ile Val Lys Tyr Arg Gly Asn Phe 
145                 150                 155                 160 


Leu Tyr Asn Thr Pro Val Lys Asp Phe Glu Ala Ser Lys Ile Asp Val 
                165                 170                 175     


Lys Asp Ser Leu Glu Lys Leu Asn Glu Leu Tyr Glu Arg Leu Asp Ser 
            180                 185                 190         


Glu Phe Thr Val Glu Leu Asp Ser Ser Asn Ala Leu Glu Ile Glu Lys 
        195                 200                 205             


Ile Ile Arg Asp Lys Lys Val Phe Lys Ile Asn Lys Val Lys Ser Ile 
    210                 215                 220                 


His Gln Leu Leu Ser Leu Lys Thr Glu Asn Lys Glu Arg Thr Lys Leu 
225                 230                 235                 240 


Ile Lys Asp Val Ser Lys Gln Ile Ile Asn Ala Ile Leu Gly Tyr Lys 
                245                 250                 255     


Thr Lys Phe Glu Thr Ile Leu Leu Lys Asn Ile Ser Lys Asp Glu Ala 
            260                 265                 270         


Asp Asp Trp Glu Phe Lys Leu Thr Asp Val Asp Ala Asp Asn Lys Phe 
        275                 280                 285             


Glu Asn Leu Ile Gly Asp Leu Asn Glu Asn Glu Gln Glu Ile Leu Leu 
    290                 295                 300                 


Glu Ile Arg Asn Leu Ala Asn Ala Ile Thr Leu Ser Asn Ile Val Glu 
305                 310                 315                 320 


Glu Gly Lys Thr Leu Ser Glu Ser Met Ile Asp Lys Tyr Asn Lys His 
                325                 330                 335     


Ser Asp Asp Leu Glu Leu Leu Lys Gln Val Ile Ser Asp His Pro Asp 
            340                 345                 350         


Arg Asp Lys Ala Lys Lys Leu Ala Leu Ala Tyr Asp Leu Tyr Val Asn 
        355                 360                 365             


Asn Arg His Gly Lys Leu Leu Gln Ala Lys Asp Val Leu Gly Ser Lys 
    370                 375                 380                 


Lys Thr Leu Ser Lys Glu Asp Phe Tyr Lys Glu Val Lys Lys Asn Leu 
385                 390                 395                 400 


Asp Asp Ser Lys Ala Ser Gln Glu Ile Leu Asp Thr Ile Ala Leu Asp 
                405                 410                 415     


Ser Phe Met Pro Lys Gln Arg Thr Asn Glu Asn Gly Val Ile Pro Tyr 
            420                 425                 430         


Gln Leu His Gln Leu Glu Leu Asp Arg Ile Ile Lys Asn Gln Gly Lys 
        435                 440                 445             


Tyr Tyr Pro Phe Leu Lys Glu Val Asn Pro Val Ser Ser His Leu Lys 
    450                 455                 460                 


Glu Ala Pro Tyr Lys Leu Asp Glu Leu Ile Arg Phe Arg Val Pro Tyr 
465                 470                 475                 480 


Tyr Val Gly Pro Leu Ile Ser Pro Asn Glu Ser Thr Lys Asn Lys Gln 
                485                 490                 495     


Thr Lys Lys Asn Gln Asn Phe Ala Trp Met Ile Arg Lys Glu Gln Gly 
            500                 505                 510         


Gln Ile Thr Pro Trp Asn Phe Asp Gln Lys Val Asp Arg Met Ala Ser 
        515                 520                 525             


Ala Asn Lys Phe Ile Lys Arg Met Thr Thr Lys Asp Thr Tyr Leu Leu 
    530                 535                 540                 


Gly Glu Asp Val Leu Pro Ala Asn Ser Leu Leu Tyr Gln Lys Phe Thr 
545                 550                 555                 560 


Val Leu Asn Glu Leu Asn Asn Ile Lys Ile Asn Gly Lys Arg Ile Ser 
                565                 570                 575     


Val Pro Leu Lys Glu Glu Leu Tyr Asn Asn Leu Phe Lys Lys Asn Ser 
            580                 585                 590         


Thr Val Thr Thr Asn Lys Leu Lys Ser Tyr Leu Lys Glu Asn Tyr Asn 
        595                 600                 605             


Leu Ile Asn Val Glu Ile Lys Gly Leu Ala Asp Glu Lys Lys Phe Asn 
    610                 615                 620                 


Ser Gly Leu Thr Thr Tyr Asn Lys Leu Arg Asn Leu Lys Ile Phe Asp 
625                 630                 635                 640 


Gln Gln Leu Asp Asp Leu Asn Tyr Asp Lys Asp Phe Glu Arg Ile Ile 
                645                 650                 655     


Glu Trp Ser Thr Ile Phe Glu Asp Lys Ala Ile Tyr Lys Asp Lys Leu 
            660                 665                 670         


Lys Thr Ile Lys Trp Leu Ser Asp Arg Gln Ile Asp Lys Leu Ser Lys 
        675                 680                 685             


Ile Arg Met Gln Gly Trp Gly Gln Leu Ser Lys Lys Leu Leu Ser Gln 
    690                 695                 700                 


Leu Thr Asp Asn Asn Gly Gln Thr Ile Ile Glu Gln Leu Trp Asp Ser 
705                 710                 715                 720 


Gln Asn Asn Phe Met Gln Ile Val Asn Gln Ser Asp Phe Lys Asp Ala 
                725                 730                 735     


Ile Ala Val Ala Asn Gln Asn Leu Leu Val Asn Thr Ser Val Glu Asp 
            740                 745                 750         


Ile Leu Asn Glu Ala Tyr Thr Ser Pro Ala Asn Lys Lys Ala Ile Arg 
        755                 760                 765             


Gln Val Val Lys Val Val Asp Asp Ile Val Lys Ala Ala Ser Gly Lys 
    770                 775                 780                 


Val Pro Lys Gln Ile Ala Ile Glu Phe Thr Arg Asp Ala Asp Asp Lys 
785                 790                 795                 800 


Ala Lys Ile Ser Gln Thr Arg Ala Asn Lys Leu Arg Lys Val Tyr Lys 
                805                 810                 815     


Glu Leu Ser Asn Glu Leu Ala Ser Glu Thr Ile Arg Asn Glu Leu Glu 
            820                 825                 830         


Arg Val Ala Lys Asp Gln Lys Leu Leu Lys Asp Lys Tyr Tyr Leu Tyr 
        835                 840                 845             


Phe Met Gln Leu Gly Arg Asp Ala Tyr Thr Gly Glu Pro Ile Asn Ile 
    850                 855                 860                 


Asp Asp Leu Gly Gln Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Phe 
865                 870                 875                 880 


Ile Lys Asp Asp Ser Leu Glu Asn Arg Val Leu Val Lys Lys Ala Val 
                885                 890                 895     


Asn Asn Gly Lys Ser Asp Asn Val Pro Val Lys Leu Tyr Gly Asn Arg 
            900                 905                 910         


Met Ala Ala Asp Leu Gly Met Thr Ile Arg His Met Trp Glu Lys Trp 
        915                 920                 925             


Lys Asp Gln Gly Leu Ile Thr Lys Thr Lys Tyr Asn Asn Leu Ile Ile 
    930                 935                 940                 


Asp Pro Asp Lys Ile Asn Lys Tyr Glu Ser Ser Gly Phe Ile His Arg 
945                 950                 955                 960 


Gln Leu Val Glu Thr Ser Gln Ile Ile Lys Leu Val Ser Thr Ile Leu 
                965                 970                 975     


Gln Ser Lys Tyr Pro Asp Thr Glu Ile Ile Val Val Lys Ala Arg Tyr 
            980                 985                 990         


Asn His Tyr Leu Arg Lys His Leu  Asn Leu Tyr Lys Ser  Arg Glu Val 
        995                 1000                 1005             


Asn Asp  Tyr His His Ala Ile  Asp Ala Tyr Leu Ser  Ala Ile Cys 
    1010                 1015                 1020             


Gly Asn  Leu Leu Tyr Gln Val  Tyr Pro Tyr Leu Arg  Pro Phe Phe 
    1025                 1030                 1035             


Val Tyr  Gly Gln Tyr Lys Lys  Phe Ser Ser Asp Pro  Lys Lys Glu 
    1040                 1045                 1050             


Lys Ile  Ile Tyr Asp Lys Thr  Arg Lys Tyr Asn Phe  Ile Ser Gln 
    1055                 1060                 1065             


Ile Phe  Glu Asn Lys Ser Asn  Asp Ile Ile Ser Leu  Glu Thr Lys 
    1070                 1075                 1080             


Lys Lys  Val Phe Asp Lys Lys  Asp Ile Ile Glu Lys  Leu Lys His 
    1085                 1090                 1095             


Ala Tyr  Asn Tyr Lys Tyr Met  Leu Val Ser Arg Glu  Thr Glu Thr 
    1100                 1105                 1110             


His Asp  Gln Glu Met Phe Lys  Met Thr Val Tyr Pro  Arg Leu Ser 
    1115                 1120                 1125             


Arg Asp  Thr Lys Lys Ser Arg  Asn Leu Ile Ser Lys  Lys Lys Asp 
    1130                 1135                 1140             


Met Pro  Thr Glu Ile Tyr Gly  Gly Tyr Thr Asn Asn  Ser Asp Ala 
    1145                 1150                 1155             


Tyr Met  Val Ile Ala Arg Ile  Asn Lys Lys Lys Gly  Thr Glu Tyr 
    1160                 1165                 1170             


Arg Val  Phe Gly Val Pro Met  Arg Glu Leu Val Asn  Leu Arg Lys 
    1175                 1180                 1185             


Ala Glu  Lys Asn Gly Arg Tyr  Asn Ala Tyr Leu Lys  Gln Val Leu 
    1190                 1195                 1200             


Glu Pro  Glu Ile Met Tyr Ser  Lys Asn Gly Lys Lys  Asn Lys Thr 
    1205                 1210                 1215             


Ile Ser  Ser Phe Glu Ile Val  Lys Ala Lys Val Pro  Tyr Lys Gln 
    1220                 1225                 1230             


Val Ile  Leu Asp Gly Asp Lys  Lys Phe Met Leu Ala  Ser Ser Thr 
    1235                 1240                 1245             


Tyr Val  Gln Asn Ala Lys Gln  Leu Thr Leu Ser Gln  Asn Ser Met 
    1250                 1255                 1260             


Gln Ala  Ile Thr Asp Asn Cys  Glu Asn Asp Thr Glu  Glu Glu Lys 
    1265                 1270                 1275             


Ala Leu  Glu Glu Lys Ala Leu  Ile Glu Ala Tyr Asp  Glu Ile Leu 
    1280                 1285                 1290             


Thr Asn  Ile Asp Lys Tyr Leu  Pro Leu Phe Asp Ile  Asn Lys Phe 
    1295                 1300                 1305             


Arg Glu  Lys Leu His Ala Gly  Arg Glu Lys Phe Ile  Asn Leu Ser 
    1310                 1315                 1320             


Leu Asp  Val Lys Lys Asp Thr  Ile Leu Gln Val Leu  Asn Gly Leu 
    1325                 1330                 1335             


His Asp  Asn Ala Val Met Pro  Lys Ile Lys Ser Leu  Gly Leu Ser 
    1340                 1345                 1350             


Thr Pro  Leu Gly Phe Met Gln  Phe Ser Ser Gly Val  Pro Leu Ser 
    1355                 1360                 1365             


Glu Asn  Ala Lys Leu Ile Tyr  Gln Ser Pro Thr Gly  Leu Phe Glu 
    1370                 1375                 1380             


Lys Arg  Val Lys Ile Ser Asp  Leu 
    1385                 1390     


<210>  718
<211>  1348
<212>  PRT
<213>  Finegoldia magna ATCC 29328

<400>  718

Met Lys Ser Glu Lys Lys Tyr Tyr Ile Gly Leu Asp Val Gly Thr Asn 
1               5                   10                  15      


Ser Val Gly Trp Ala Val Thr Asp Glu Phe Tyr Asn Ile Leu Arg Ala 
            20                  25                  30          


Lys Gly Lys Asp Leu Trp Gly Val Arg Leu Phe Glu Lys Ala Asp Thr 
        35                  40                  45              


Ala Ala Asn Thr Arg Ile Phe Arg Ser Gly Arg Arg Arg Asn Asp Arg 
    50                  55                  60                  


Lys Gly Met Arg Leu Gln Ile Leu Arg Glu Ile Phe Glu Asp Glu Ile 
65                  70                  75                  80  


Lys Lys Val Asp Lys Asp Phe Tyr Asp Arg Leu Asp Glu Ser Lys Phe 
                85                  90                  95      


Trp Ala Glu Asp Lys Lys Val Ser Gly Lys Tyr Ser Leu Phe Asn Asp 
            100                 105                 110         


Lys Asn Phe Ser Asp Lys Gln Tyr Phe Glu Lys Phe Pro Thr Ile Phe 
        115                 120                 125             


His Leu Arg Lys Tyr Leu Met Glu Glu His Gly Lys Val Asp Ile Arg 
    130                 135                 140                 


Tyr Tyr Phe Leu Ala Ile Asn Gln Met Met Lys Arg Arg Gly His Phe 
145                 150                 155                 160 


Leu Ile Asp Gly Gln Ile Ser His Val Thr Asp Asp Lys Pro Leu Lys 
                165                 170                 175     


Glu Gln Leu Ile Leu Leu Ile Asn Asp Leu Leu Lys Ile Glu Leu Glu 
            180                 185                 190         


Glu Glu Leu Met Asp Ser Ile Phe Glu Ile Leu Ala Asp Val Asn Glu 
        195                 200                 205             


Lys Arg Thr Asp Lys Lys Asn Asn Leu Lys Glu Leu Ile Lys Gly Gln 
    210                 215                 220                 


Asp Phe Asn Lys Gln Glu Gly Asn Ile Leu Asn Ser Ile Phe Glu Ser 
225                 230                 235                 240 


Ile Val Thr Gly Lys Ala Lys Ile Lys Asn Ile Ile Ser Asp Glu Asp 
                245                 250                 255     


Ile Leu Glu Lys Ile Lys Glu Asp Asn Lys Glu Asp Phe Val Leu Thr 
            260                 265                 270         


Gly Asp Ser Tyr Glu Glu Asn Leu Gln Tyr Phe Glu Glu Val Leu Gln 
        275                 280                 285             


Glu Asn Ile Thr Leu Phe Asn Thr Leu Lys Ser Thr Tyr Asp Phe Leu 
    290                 295                 300                 


Ile Leu Gln Ser Ile Leu Lys Gly Lys Ser Thr Leu Ser Asp Ala Gln 
305                 310                 315                 320 


Val Glu Arg Tyr Asp Glu His Lys Lys Asp Leu Glu Ile Leu Lys Lys 
                325                 330                 335     


Val Ile Lys Lys Tyr Asp Glu Asp Gly Lys Leu Phe Lys Gln Val Phe 
            340                 345                 350         


Lys Glu Asp Asn Gly Asn Gly Tyr Val Ser Tyr Ile Gly Tyr Tyr Leu 
        355                 360                 365             


Asn Lys Asn Lys Lys Ile Thr Ala Lys Lys Lys Ile Ser Asn Ile Glu 
    370                 375                 380                 


Phe Thr Lys Tyr Val Lys Gly Ile Leu Glu Lys Gln Cys Asp Cys Glu 
385                 390                 395                 400 


Asp Glu Asp Val Lys Tyr Leu Leu Gly Lys Ile Glu Gln Glu Asn Phe 
                405                 410                 415     


Leu Leu Lys Gln Ile Ser Ser Ile Asn Ser Val Ile Pro His Gln Ile 
            420                 425                 430         


His Leu Phe Glu Leu Asp Lys Ile Leu Glu Asn Leu Ala Lys Asn Tyr 
        435                 440                 445             


Pro Ser Phe Asn Asn Lys Lys Glu Glu Phe Thr Lys Ile Glu Lys Ile 
    450                 455                 460                 


Arg Lys Thr Phe Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn 
465                 470                 475                 480 


Asp Tyr His Lys Asn Asn Gly Gly Asn Ala Trp Ile Phe Arg Asn Lys 
                485                 490                 495     


Gly Glu Lys Ile Arg Pro Trp Asn Phe Glu Lys Ile Val Asp Leu His 
            500                 505                 510         


Lys Ser Glu Glu Glu Phe Ile Lys Arg Met Leu Asn Gln Cys Thr Tyr 
        515                 520                 525             


Leu Pro Glu Glu Thr Val Leu Pro Lys Ser Ser Ile Leu Tyr Ser Glu 
    530                 535                 540                 


Tyr Met Val Leu Asn Glu Leu Asn Asn Leu Arg Ile Asn Gly Lys Pro 
545                 550                 555                 560 


Leu Asp Thr Asp Val Lys Leu Lys Leu Ile Glu Glu Leu Phe Lys Lys 
                565                 570                 575     


Lys Thr Lys Val Thr Leu Lys Ser Ile Arg Asp Tyr Met Val Arg Asn 
            580                 585                 590         


Asn Phe Ala Asp Lys Glu Asp Phe Asp Asn Ser Glu Lys Asn Leu Glu 
        595                 600                 605             


Ile Ala Ser Asn Met Lys Ser Tyr Ile Asp Phe Asn Asn Ile Leu Glu 
    610                 615                 620                 


Asp Lys Phe Asp Val Glu Met Val Glu Asp Leu Ile Glu Lys Ile Thr 
625                 630                 635                 640 


Ile His Thr Gly Asn Lys Lys Leu Leu Lys Lys Tyr Ile Glu Glu Thr 
                645                 650                 655     


Tyr Pro Asp Leu Ser Ser Ser Gln Ile Gln Lys Ile Ile Asn Leu Lys 
            660                 665                 670         


Tyr Lys Asp Trp Gly Arg Leu Ser Arg Lys Leu Leu Asp Gly Ile Lys 
        675                 680                 685             


Gly Thr Lys Lys Glu Thr Glu Lys Thr Asp Thr Val Ile Asn Phe Leu 
    690                 695                 700                 


Arg Asn Ser Ser Asp Asn Leu Met Gln Ile Ile Gly Ser Gln Asn Tyr 
705                 710                 715                 720 


Ser Phe Asn Glu Tyr Ile Asp Lys Leu Arg Lys Lys Tyr Ile Pro Gln 
                725                 730                 735     


Glu Ile Ser Tyr Glu Val Val Glu Asn Leu Tyr Val Ser Pro Ser Val 
            740                 745                 750         


Lys Lys Met Ile Trp Gln Val Ile Arg Val Thr Glu Glu Ile Thr Lys 
        755                 760                 765             


Val Met Gly Tyr Asp Pro Asp Lys Ile Phe Ile Glu Met Ala Lys Ser 
    770                 775                 780                 


Glu Glu Glu Lys Lys Thr Thr Ile Ser Arg Lys Asn Lys Leu Leu Asp 
785                 790                 795                 800 


Leu Tyr Lys Ala Ile Lys Lys Asp Glu Arg Asp Ser Gln Tyr Glu Lys 
                805                 810                 815     


Leu Leu Thr Gly Leu Asn Lys Leu Asp Asp Ser Asp Leu Arg Ser Arg 
            820                 825                 830         


Lys Leu Tyr Leu Tyr Tyr Thr Gln Met Gly Arg Asp Met Tyr Thr Gly 
        835                 840                 845             


Glu Lys Ile Asp Leu Asp Lys Leu Phe Asp Ser Thr His Tyr Asp Lys 
    850                 855                 860                 


Asp His Ile Ile Pro Gln Ser Met Lys Lys Asp Asp Ser Ile Ile Asn 
865                 870                 875                 880 


Asn Leu Val Leu Val Asn Lys Asn Ala Asn Gln Thr Thr Lys Gly Asn 
                885                 890                 895     


Ile Tyr Pro Val Pro Ser Ser Ile Arg Asn Asn Pro Lys Ile Tyr Asn 
            900                 905                 910         


Tyr Trp Lys Tyr Leu Met Glu Lys Glu Phe Ile Ser Lys Glu Lys Tyr 
        915                 920                 925             


Asn Arg Leu Ile Arg Asn Thr Pro Leu Thr Asn Glu Glu Leu Gly Gly 
    930                 935                 940                 


Phe Ile Asn Arg Gln Leu Val Glu Thr Arg Gln Ser Thr Lys Ala Ile 
945                 950                 955                 960 


Lys Glu Leu Phe Glu Lys Phe Tyr Gln Lys Ser Lys Ile Ile Pro Val 
                965                 970                 975     


Lys Ala Ser Leu Ala Ser Asp Leu Arg Lys Asp Met Asn Thr Leu Lys 
            980                 985                 990         


Ser Arg Glu Val Asn Asp Leu His  His Ala His Asp Ala  Phe Leu Asn 
        995                 1000                 1005             


Ile Val  Ala Gly Asp Val Trp  Asn Arg Glu Phe Thr  Ser Asn Pro 
    1010                 1015                 1020             


Ile Asn  Tyr Val Lys Glu Asn  Arg Glu Gly Asp Lys  Val Lys Tyr 
    1025                 1030                 1035             


Ser Leu  Ser Lys Asp Phe Thr  Arg Pro Arg Lys Ser  Lys Gly Lys 
    1040                 1045                 1050             


Val Ile  Trp Thr Pro Glu Lys  Gly Arg Lys Leu Ile  Val Asp Thr 
    1055                 1060                 1065             


Leu Asn  Lys Pro Ser Val Leu  Ile Ser Asn Glu Ser  His Val Lys 
    1070                 1075                 1080             


Lys Gly  Glu Leu Phe Asn Ala  Thr Ile Ala Gly Lys  Lys Asp Tyr 
    1085                 1090                 1095             


Lys Lys  Gly Lys Ile Tyr Leu  Pro Leu Lys Lys Asp  Asp Arg Leu 
    1100                 1105                 1110             


Gln Asp  Val Ser Lys Tyr Gly  Gly Tyr Lys Ala Ile  Asn Gly Ala 
    1115                 1120                 1125             


Phe Phe  Phe Leu Val Glu His  Thr Lys Ser Lys Lys  Arg Ile Arg 
    1130                 1135                 1140             


Ser Ile  Glu Leu Phe Pro Leu  His Leu Leu Ser Lys  Phe Tyr Glu 
    1145                 1150                 1155             


Asp Lys  Asn Thr Val Leu Asp  Tyr Ala Ile Asn Val  Leu Gln Leu 
    1160                 1165                 1170             


Gln Asp  Pro Lys Ile Ile Ile  Asp Lys Ile Asn Tyr  Arg Thr Glu 
    1175                 1180                 1185             


Ile Ile  Ile Asp Asn Phe Ser  Tyr Leu Ile Ser Thr  Lys Ser Asn 
    1190                 1195                 1200             


Asp Gly  Ser Ile Thr Val Lys  Pro Asn Glu Gln Met  Tyr Trp Arg 
    1205                 1210                 1215             


Val Asp  Glu Ile Ser Asn Leu  Lys Lys Ile Glu Asn  Lys Tyr Lys 
    1220                 1225                 1230             


Lys Asp  Ala Ile Leu Thr Glu  Glu Asp Arg Lys Ile  Met Glu Ser 
    1235                 1240                 1245             


Tyr Ile  Asp Lys Ile Tyr Gln  Gln Phe Lys Ala Gly  Lys Tyr Lys 
    1250                 1255                 1260             


Asn Arg  Arg Thr Thr Asp Thr  Ile Ile Glu Lys Tyr  Glu Ile Ile 
    1265                 1270                 1275             


Asp Leu  Asp Thr Leu Asp Asn  Lys Gln Leu Tyr Gln  Leu Leu Val 
    1280                 1285                 1290             


Ala Phe  Ile Ser Leu Ser Tyr  Lys Thr Ser Asn Asn  Ala Val Asp 
    1295                 1300                 1305             


Phe Thr  Val Ile Gly Leu Gly  Thr Glu Cys Gly Lys  Pro Arg Ile 
    1310                 1315                 1320             


Thr Asn  Leu Pro Asp Asn Thr  Tyr Leu Val Tyr Lys  Ser Ile Thr 
    1325                 1330                 1335             


Gly Ile  Tyr Glu Lys Arg Ile  Arg Ile Lys 
    1340                 1345             


<210>  719
<211>  1236
<212>  PRT
<213>  Mycoplasma mobile 163K

<400>  719

Met Tyr Phe Tyr Lys Asn Lys Glu Asn Lys Leu Asn Lys Lys Val Val 
1               5                   10                  15      


Leu Gly Leu Asp Leu Gly Ile Ala Ser Val Gly Trp Cys Leu Thr Asp 
            20                  25                  30          


Ile Ser Gln Lys Glu Asp Asn Lys Phe Pro Ile Ile Leu His Gly Val 
        35                  40                  45              


Arg Leu Phe Glu Thr Val Asp Asp Ser Asp Asp Lys Leu Leu Asn Glu 
    50                  55                  60                  


Thr Arg Arg Lys Lys Arg Gly Gln Arg Arg Arg Asn Arg Arg Leu Phe 
65                  70                  75                  80  


Thr Arg Lys Arg Asp Phe Ile Lys Tyr Leu Ile Asp Asn Asn Ile Ile 
                85                  90                  95      


Glu Leu Glu Phe Asp Lys Asn Pro Lys Ile Leu Val Arg Asn Phe Ile 
            100                 105                 110         


Glu Lys Tyr Ile Asn Pro Phe Ser Lys Asn Leu Glu Leu Lys Tyr Lys 
        115                 120                 125             


Ser Val Thr Asn Leu Pro Ile Gly Phe His Asn Leu Arg Lys Ala Ala 
    130                 135                 140                 


Ile Asn Glu Lys Tyr Lys Leu Asp Lys Ser Glu Leu Ile Val Leu Leu 
145                 150                 155                 160 


Tyr Phe Tyr Leu Ser Leu Arg Gly Ala Phe Phe Asp Asn Pro Glu Asp 
                165                 170                 175     


Thr Lys Ser Lys Glu Met Asn Lys Asn Glu Ile Glu Ile Phe Asp Lys 
            180                 185                 190         


Asn Glu Ser Ile Lys Asn Ala Glu Phe Pro Ile Asp Lys Ile Ile Glu 
        195                 200                 205             


Phe Tyr Lys Ile Ser Gly Lys Ile Arg Ser Thr Ile Asn Leu Lys Phe 
    210                 215                 220                 


Gly His Gln Asp Tyr Leu Lys Glu Ile Lys Gln Val Phe Glu Lys Gln 
225                 230                 235                 240 


Asn Ile Asp Phe Met Asn Tyr Glu Lys Phe Ala Met Glu Glu Lys Ser 
                245                 250                 255     


Phe Phe Ser Arg Ile Arg Asn Tyr Ser Glu Gly Pro Gly Asn Glu Lys 
            260                 265                 270         


Ser Phe Ser Lys Tyr Gly Leu Tyr Ala Asn Glu Asn Gly Asn Pro Glu 
        275                 280                 285             


Leu Ile Ile Asn Glu Lys Gly Gln Lys Ile Tyr Thr Lys Ile Phe Lys 
    290                 295                 300                 


Thr Leu Trp Glu Ser Lys Ile Gly Lys Cys Ser Tyr Asp Lys Lys Leu 
305                 310                 315                 320 


Tyr Arg Ala Pro Lys Asn Ser Phe Ser Ala Lys Val Phe Asp Ile Thr 
                325                 330                 335     


Asn Lys Leu Thr Asp Trp Lys His Lys Asn Glu Tyr Ile Ser Glu Arg 
            340                 345                 350         


Leu Lys Arg Lys Ile Leu Leu Ser Arg Phe Leu Asn Lys Asp Ser Lys 
        355                 360                 365             


Ser Ala Val Glu Lys Ile Leu Lys Glu Glu Asn Ile Lys Phe Glu Asn 
    370                 375                 380                 


Leu Ser Glu Ile Ala Tyr Asn Lys Asp Asp Asn Lys Ile Asn Leu Pro 
385                 390                 395                 400 


Ile Ile Asn Ala Tyr His Ser Leu Thr Thr Ile Phe Lys Lys His Leu 
                405                 410                 415     


Ile Asn Phe Glu Asn Tyr Leu Ile Ser Asn Glu Asn Asp Leu Ser Lys 
            420                 425                 430         


Leu Met Ser Phe Tyr Lys Gln Gln Ser Glu Lys Leu Phe Val Pro Asn 
        435                 440                 445             


Glu Lys Gly Ser Tyr Glu Ile Asn Gln Asn Asn Asn Val Leu His Ile 
    450                 455                 460                 


Phe Asp Ala Ile Ser Asn Ile Leu Asn Lys Phe Ser Thr Ile Gln Asp 
465                 470                 475                 480 


Arg Ile Arg Ile Leu Glu Gly Tyr Phe Glu Phe Ser Asn Leu Lys Lys 
                485                 490                 495     


Asp Val Lys Ser Ser Glu Ile Tyr Ser Glu Ile Ala Lys Leu Arg Glu 
            500                 505                 510         


Phe Ser Gly Thr Ser Ser Leu Ser Phe Gly Ala Tyr Tyr Lys Phe Ile 
        515                 520                 525             


Pro Asn Leu Ile Ser Glu Gly Ser Lys Asn Tyr Ser Thr Ile Ser Tyr 
    530                 535                 540                 


Glu Glu Lys Ala Leu Gln Asn Gln Lys Asn Asn Phe Ser His Ser Asn 
545                 550                 555                 560 


Leu Phe Glu Lys Thr Trp Val Glu Asp Leu Ile Ala Ser Pro Thr Val 
                565                 570                 575     


Lys Arg Ser Leu Arg Gln Thr Met Asn Leu Leu Lys Glu Ile Phe Lys 
            580                 585                 590         


Tyr Ser Glu Lys Asn Asn Leu Glu Ile Glu Lys Ile Val Val Glu Val 
        595                 600                 605             


Thr Arg Ser Ser Asn Asn Lys His Glu Arg Lys Lys Ile Glu Gly Ile 
    610                 615                 620                 


Asn Lys Tyr Arg Lys Glu Lys Tyr Glu Glu Leu Lys Lys Val Tyr Asp 
625                 630                 635                 640 


Leu Pro Asn Glu Asn Thr Thr Leu Leu Lys Lys Leu Trp Leu Leu Arg 
                645                 650                 655     


Gln Gln Gln Gly Tyr Asp Ala Tyr Ser Leu Arg Lys Ile Glu Ala Asn 
            660                 665                 670         


Asp Val Ile Asn Lys Pro Trp Asn Tyr Asp Ile Asp His Ile Val Pro 
        675                 680                 685             


Arg Ser Ile Ser Phe Asp Asp Ser Phe Ser Asn Leu Val Ile Val Asn 
    690                 695                 700                 


Lys Leu Asp Asn Ala Lys Lys Ser Asn Asp Leu Ser Ala Lys Gln Phe 
705                 710                 715                 720 


Ile Glu Lys Ile Tyr Gly Ile Glu Lys Leu Lys Glu Ala Lys Glu Asn 
                725                 730                 735     


Trp Gly Asn Trp Tyr Leu Arg Asn Ala Asn Gly Lys Ala Phe Asn Asp 
            740                 745                 750         


Lys Gly Lys Phe Ile Lys Leu Tyr Thr Ile Asp Asn Leu Asp Glu Phe 
        755                 760                 765             


Asp Asn Ser Asp Phe Ile Asn Arg Asn Leu Ser Asp Thr Ser Tyr Ile 
    770                 775                 780                 


Thr Asn Ala Leu Val Asn His Leu Thr Phe Ser Asn Ser Lys Tyr Lys 
785                 790                 795                 800 


Tyr Ser Val Val Ser Val Asn Gly Lys Gln Thr Ser Asn Leu Arg Asn 
                805                 810                 815     


Gln Ile Ala Phe Val Gly Ile Lys Asn Asn Lys Glu Thr Glu Arg Glu 
            820                 825                 830         


Trp Lys Arg Pro Glu Gly Phe Lys Ser Ile Asn Ser Asn Asp Phe Leu 
        835                 840                 845             


Ile Arg Glu Glu Gly Lys Asn Asp Val Lys Asp Asp Val Leu Ile Lys 
    850                 855                 860                 


Asp Arg Ser Phe Asn Gly His His Ala Glu Asp Ala Tyr Phe Ile Thr 
865                 870                 875                 880 


Ile Ile Ser Gln Tyr Phe Arg Ser Phe Lys Arg Ile Glu Arg Leu Asn 
                885                 890                 895     


Val Asn Tyr Arg Lys Glu Thr Arg Glu Leu Asp Asp Leu Glu Lys Asn 
            900                 905                 910         


Asn Ile Lys Phe Lys Glu Lys Ala Ser Phe Asp Asn Phe Leu Leu Ile 
        915                 920                 925             


Asn Ala Leu Asp Glu Leu Asn Glu Lys Leu Asn Gln Met Arg Phe Ser 
    930                 935                 940                 


Arg Met Val Ile Thr Lys Lys Asn Thr Gln Leu Phe Asn Glu Thr Leu 
945                 950                 955                 960 


Tyr Ser Gly Lys Tyr Asp Lys Gly Lys Asn Thr Ile Lys Lys Val Glu 
                965                 970                 975     


Lys Leu Asn Leu Leu Asp Asn Arg Thr Asp Lys Ile Lys Lys Ile Glu 
            980                 985                 990         


Glu Phe Phe Asp Glu Asp Lys Leu  Lys Glu Asn Glu Leu  Thr Lys Leu 
        995                 1000                 1005             


His Ile  Phe Asn His Asp Lys  Asn Leu Tyr Glu Thr  Leu Lys Ile 
    1010                 1015                 1020             


Ile Trp  Asn Glu Val Lys Ile  Glu Ile Lys Asn Lys  Asn Leu Asn 
    1025                 1030                 1035             


Glu Lys  Asn Tyr Phe Lys Tyr  Phe Val Asn Lys Lys  Leu Gln Glu 
    1040                 1045                 1050             


Gly Lys  Ile Ser Phe Asn Glu  Trp Val Pro Ile Leu  Asp Asn Asp 
    1055                 1060                 1065             


Phe Lys  Ile Ile Arg Lys Ile  Arg Tyr Ile Lys Phe  Ser Ser Glu 
    1070                 1075                 1080             


Glu Lys  Glu Thr Asp Glu Ile  Ile Phe Ser Gln Ser  Asn Phe Leu 
    1085                 1090                 1095             


Lys Ile  Asp Gln Arg Gln Asn  Phe Ser Phe His Asn  Thr Leu Tyr 
    1100                 1105                 1110             


Trp Val  Gln Ile Trp Val Tyr  Lys Asn Gln Lys Asp  Gln Tyr Cys 
    1115                 1120                 1125             


Phe Ile  Ser Ile Asp Ala Arg  Asn Ser Lys Phe Glu  Lys Asp Glu 
    1130                 1135                 1140             


Ile Lys  Ile Asn Tyr Glu Lys  Leu Lys Thr Gln Lys  Glu Lys Leu 
    1145                 1150                 1155             


Gln Ile  Ile Asn Glu Glu Pro  Ile Leu Lys Ile Asn  Lys Gly Asp 
    1160                 1165                 1170             


Leu Phe  Glu Asn Glu Glu Lys  Glu Leu Phe Tyr Ile  Val Gly Arg 
    1175                 1180                 1185             


Asp Glu  Lys Pro Gln Lys Leu  Glu Ile Lys Tyr Ile  Leu Gly Lys 
    1190                 1195                 1200             


Lys Ile  Lys Asp Gln Lys Gln  Ile Gln Lys Pro Val  Lys Lys Tyr 
    1205                 1210                 1215             


Phe Pro  Asn Trp Lys Lys Val  Asn Leu Thr Tyr Met  Gly Glu Ile 
    1220                 1225                 1230             


Phe Lys  Lys 
    1235     


<210>  720
<211>  1269
<212>  PRT
<213>  Mycoplasma gallisepticum str. F

<400>  720

Met Asn Asn Ser Ile Lys Ser Lys Pro Glu Val Thr Ile Gly Leu Asp 
1               5                   10                  15      


Leu Gly Val Gly Ser Val Gly Trp Ala Ile Val Asp Asn Glu Thr Asn 
            20                  25                  30          


Ile Ile His His Leu Gly Ser Arg Leu Phe Ser Gln Ala Lys Thr Ala 
        35                  40                  45              


Glu Asp Arg Arg Ser Phe Arg Gly Val Arg Arg Leu Ile Arg Arg Arg 
    50                  55                  60                  


Lys Tyr Lys Leu Lys Arg Phe Val Asn Leu Ile Trp Lys Tyr Asn Ser 
65                  70                  75                  80  


Tyr Phe Gly Phe Lys Asn Lys Glu Asp Ile Leu Asn Asn Tyr Gln Glu 
                85                  90                  95      


Gln Gln Lys Leu His Asn Thr Val Leu Asn Leu Lys Ser Glu Ala Leu 
            100                 105                 110         


Asn Ala Lys Ile Asp Pro Lys Ala Leu Ser Trp Ile Leu His Asp Tyr 
        115                 120                 125             


Leu Lys Asn Arg Gly His Phe Tyr Glu Asp Asn Arg Asp Phe Asn Val 
    130                 135                 140                 


Tyr Pro Thr Lys Glu Leu Ala Lys Tyr Phe Asp Lys Tyr Gly Tyr Tyr 
145                 150                 155                 160 


Lys Gly Ile Ile Asp Ser Lys Glu Asp Asn Asp Asn Lys Leu Glu Glu 
                165                 170                 175     


Glu Leu Thr Lys Tyr Lys Phe Ser Asn Lys His Trp Leu Glu Glu Val 
            180                 185                 190         


Lys Lys Val Leu Ser Asn Gln Thr Gly Leu Pro Glu Lys Phe Lys Glu 
        195                 200                 205             


Glu Tyr Glu Ser Leu Phe Ser Tyr Val Arg Asn Tyr Ser Glu Gly Pro 
    210                 215                 220                 


Gly Ser Ile Asn Ser Val Ser Pro Tyr Gly Ile Tyr His Leu Asp Glu 
225                 230                 235                 240 


Lys Glu Gly Lys Val Val Gln Lys Tyr Asn Asn Ile Trp Asp Lys Thr 
                245                 250                 255     


Ile Gly Lys Cys Asn Ile Phe Pro Asp Glu Tyr Arg Ala Pro Lys Asn 
            260                 265                 270         


Ser Pro Ile Ala Met Ile Phe Asn Glu Ile Asn Glu Leu Ser Thr Ile 
        275                 280                 285             


Arg Ser Tyr Ser Ile Tyr Leu Thr Gly Trp Phe Ile Asn Gln Glu Phe 
    290                 295                 300                 


Lys Lys Ala Tyr Leu Asn Lys Leu Leu Asp Leu Leu Ile Lys Thr Asn 
305                 310                 315                 320 


Gly Glu Lys Pro Ile Asp Ala Arg Gln Phe Lys Lys Leu Arg Glu Glu 
                325                 330                 335     


Thr Ile Ala Glu Ser Ile Gly Lys Glu Thr Leu Lys Asp Val Glu Asn 
            340                 345                 350         


Glu Glu Lys Leu Glu Lys Glu Asp His Lys Trp Lys Leu Lys Gly Leu 
        355                 360                 365             


Lys Leu Asn Thr Asn Gly Lys Ile Gln Tyr Asn Asp Leu Ser Ser Leu 
    370                 375                 380                 


Ala Lys Phe Val His Lys Leu Lys Gln His Leu Lys Leu Asp Phe Leu 
385                 390                 395                 400 


Leu Glu Asp Gln Tyr Ala Thr Leu Asp Lys Ile Asn Phe Leu Gln Ser 
                405                 410                 415     


Leu Phe Val Tyr Leu Gly Lys His Leu Arg Tyr Ser Asn Arg Val Asp 
            420                 425                 430         


Ser Ala Asn Leu Lys Glu Phe Ser Asp Ser Asn Lys Leu Phe Glu Arg 
        435                 440                 445             


Ile Leu Gln Lys Gln Lys Asp Gly Leu Phe Lys Leu Phe Glu Gln Thr 
    450                 455                 460                 


Asp Lys Asp Asp Glu Lys Ile Leu Ala Gln Thr His Ser Leu Ser Thr 
465                 470                 475                 480 


Lys Ala Met Leu Leu Ala Ile Thr Arg Met Thr Asn Leu Asp Asn Asp 
                485                 490                 495     


Glu Asp Asn Gln Lys Asn Asn Asp Lys Gly Trp Asn Phe Glu Ala Ile 
            500                 505                 510         


Lys Asn Phe Asp Gln Lys Phe Ile Asp Ile Thr Lys Lys Asn Asn Asn 
        515                 520                 525             


Leu Ser Leu Lys Gln Asn Lys Arg Tyr Leu Asp Asp Arg Phe Ile Asn 
    530                 535                 540                 


Asp Ala Ile Leu Ser Pro Gly Val Lys Arg Ile Leu Arg Glu Ala Thr 
545                 550                 555                 560 


Lys Val Phe Asn Ala Ile Leu Lys Gln Phe Ser Glu Glu Tyr Asp Val 
                565                 570                 575     


Thr Lys Val Val Ile Glu Leu Ala Arg Glu Leu Ser Glu Glu Lys Glu 
            580                 585                 590         


Leu Glu Asn Thr Lys Asn Tyr Lys Lys Leu Ile Lys Lys Asn Gly Asp 
        595                 600                 605             


Lys Ile Ser Glu Gly Leu Lys Ala Leu Gly Ile Ser Glu Asp Glu Ile 
    610                 615                 620                 


Lys Asp Ile Leu Lys Ser Pro Thr Lys Ser Tyr Lys Phe Leu Leu Trp 
625                 630                 635                 640 


Leu Gln Gln Asp His Ile Asp Pro Tyr Ser Leu Lys Glu Ile Ala Phe 
                645                 650                 655     


Asp Asp Ile Phe Thr Lys Thr Glu Lys Phe Glu Ile Asp His Ile Ile 
            660                 665                 670         


Pro Tyr Ser Ile Ser Phe Asp Asp Ser Ser Ser Asn Lys Leu Leu Val 
        675                 680                 685             


Leu Ala Glu Ser Asn Gln Ala Lys Ser Asn Gln Thr Pro Tyr Glu Phe 
    690                 695                 700                 


Ile Ser Ser Gly Asn Ala Gly Ile Lys Trp Glu Asp Tyr Glu Ala Tyr 
705                 710                 715                 720 


Cys Arg Lys Phe Lys Asp Gly Asp Ser Ser Leu Leu Asp Ser Thr Gln 
                725                 730                 735     


Arg Ser Lys Lys Phe Ala Lys Met Met Lys Thr Asp Thr Ser Ser Lys 
            740                 745                 750         


Tyr Asp Ile Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala 
        755                 760                 765             


Thr Ile Val Phe Arg Asp Ala Leu Glu Asp Tyr Ala Asn Asn His Leu 
    770                 775                 780                 


Val Glu Asp Lys Pro Met Phe Lys Val Val Cys Ile Asn Gly Ser Val 
785                 790                 795                 800 


Thr Ser Phe Leu Arg Lys Asn Phe Asp Asp Ser Ser Tyr Ala Lys Lys 
                805                 810                 815     


Asp Arg Asp Lys Asn Ile His His Ala Val Asp Ala Ser Ile Ile Ser 
            820                 825                 830         


Ile Phe Ser Asn Glu Thr Lys Thr Leu Phe Asn Gln Leu Thr Gln Phe 
        835                 840                 845             


Ala Asp Tyr Lys Leu Phe Lys Asn Thr Asp Gly Ser Trp Lys Lys Ile 
    850                 855                 860                 


Asp Pro Lys Thr Gly Val Val Thr Glu Val Thr Asp Glu Asn Trp Lys 
865                 870                 875                 880 


Gln Ile Arg Val Arg Asn Gln Val Ser Glu Ile Ala Lys Val Ile Glu 
                885                 890                 895     


Lys Tyr Ile Gln Asp Ser Asn Ile Glu Arg Lys Ala Arg Tyr Ser Arg 
            900                 905                 910         


Lys Ile Glu Asn Lys Thr Asn Ile Ser Leu Phe Asn Asp Thr Val Tyr 
        915                 920                 925             


Ser Ala Lys Lys Val Gly Tyr Glu Asp Gln Ile Lys Arg Lys Asn Leu 
    930                 935                 940                 


Lys Thr Leu Asp Ile His Glu Ser Ala Lys Glu Asn Lys Asn Ser Lys 
945                 950                 955                 960 


Val Lys Arg Gln Phe Val Tyr Arg Lys Leu Val Asn Val Ser Leu Leu 
                965                 970                 975     


Asn Asn Asp Lys Leu Ala Asp Leu Phe Ala Glu Lys Glu Asp Ile Leu 
            980                 985                 990         


Met Tyr Arg Ala Asn Pro Trp Val  Ile Asn Leu Ala Glu  Gln Ile Phe 
        995                 1000                 1005             


Asn Glu  Tyr Thr Glu Asn Lys  Lys Ile Lys Ser Gln  Asn Val Phe 
    1010                 1015                 1020             


Glu Lys  Tyr Met Leu Asp Leu  Thr Lys Glu Phe Pro  Glu Lys Phe 
    1025                 1030                 1035             


Ser Glu  Phe Leu Val Lys Ser  Met Leu Arg Asn Lys  Thr Ala Ile 
    1040                 1045                 1050             


Ile Tyr  Asp Asp Lys Lys Asn  Ile Val His Arg Ile  Lys Arg Leu 
    1055                 1060                 1065             


Lys Met  Leu Ser Ser Glu Leu  Lys Glu Asn Lys Leu  Ser Asn Val 
    1070                 1075                 1080             


Ile Ile  Arg Ser Lys Asn Gln  Ser Gly Thr Lys Leu  Ser Tyr Gln 
    1085                 1090                 1095             


Asp Thr  Ile Asn Ser Leu Ala  Leu Met Ile Met Arg  Ser Ile Asp 
    1100                 1105                 1110             


Pro Thr  Ala Lys Lys Gln Tyr  Ile Arg Val Pro Leu  Asn Thr Leu 
    1115                 1120                 1125             


Asn Leu  His Leu Gly Asp His  Asp Phe Asp Leu His  Asn Met Asp 
    1130                 1135                 1140             


Ala Tyr  Leu Lys Lys Pro Lys  Phe Val Lys Tyr Leu  Lys Ala Asn 
    1145                 1150                 1155             


Glu Ile  Gly Asp Glu Tyr Lys  Pro Trp Arg Val Leu  Thr Ser Gly 
    1160                 1165                 1170             


Thr Leu  Leu Ile His Lys Lys  Asp Lys Lys Leu Met  Tyr Ile Ser 
    1175                 1180                 1185             


Ser Phe  Gln Asn Leu Asn Asp  Val Ile Glu Ile Lys  Asn Leu Ile 
    1190                 1195                 1200             


Glu Thr  Glu Tyr Lys Glu Asn  Asp Asp Ser Asp Ser  Lys Lys Lys 
    1205                 1210                 1215             


Lys Lys  Ala Asn Arg Phe Leu  Met Thr Leu Ser Thr  Ile Leu Asn 
    1220                 1225                 1230             


Asp Tyr  Ile Leu Leu Asp Ala  Lys Asp Asn Phe Asp  Ile Leu Gly 
    1235                 1240                 1245             


Leu Ser  Lys Asn Arg Ile Asp  Glu Ile Leu Asn Ser  Lys Leu Gly 
    1250                 1255                 1260             


Leu Asp  Lys Ile Val Lys 
    1265                 


<210>  721
<211>  1265
<212>  PRT
<213>  Mycoplasma ovipneumoniae SC01

<400>  721

Met His Asn Lys Lys Asn Ile Thr Ile Gly Phe Asp Leu Gly Ile Ala 
1               5                   10                  15      


Ser Ile Gly Trp Ala Ile Ile Asp Ser Thr Thr Ser Lys Ile Leu Asp 
            20                  25                  30          


Trp Gly Thr Arg Thr Phe Glu Glu Arg Lys Thr Ala Asn Glu Arg Arg 
        35                  40                  45              


Ala Phe Arg Ser Thr Arg Arg Asn Ile Arg Arg Lys Ala Tyr Arg Asn 
    50                  55                  60                  


Gln Arg Phe Ile Asn Leu Ile Leu Lys Tyr Lys Asp Leu Phe Glu Leu 
65                  70                  75                  80  


Lys Asn Ile Ser Asp Ile Gln Arg Ala Asn Lys Lys Asp Thr Glu Asn 
                85                  90                  95      


Tyr Glu Lys Ile Ile Ser Phe Phe Thr Glu Ile Tyr Lys Lys Cys Ala 
            100                 105                 110         


Ala Lys His Ser Asn Ile Leu Glu Val Lys Val Lys Ala Leu Asp Ser 
        115                 120                 125             


Lys Ile Glu Lys Leu Asp Leu Ile Trp Ile Leu His Asp Tyr Leu Glu 
    130                 135                 140                 


Asn Arg Gly Phe Phe Tyr Asp Leu Glu Glu Glu Asn Val Ala Asp Lys 
145                 150                 155                 160 


Tyr Glu Gly Ile Glu His Pro Ser Ile Leu Leu Tyr Asp Phe Phe Lys 
                165                 170                 175     


Lys Asn Gly Phe Phe Lys Ser Asn Ser Ser Ile Pro Lys Asp Leu Gly 
            180                 185                 190         


Gly Tyr Ser Phe Ser Asn Leu Gln Trp Val Asn Glu Ile Lys Lys Leu 
        195                 200                 205             


Phe Glu Val Gln Glu Ile Asn Pro Glu Phe Ser Glu Lys Phe Leu Asn 
    210                 215                 220                 


Leu Phe Thr Ser Val Arg Asp Tyr Ala Lys Gly Pro Gly Ser Glu His 
225                 230                 235                 240 


Ser Ala Ser Glu Tyr Gly Ile Phe Gln Lys Asp Glu Lys Gly Lys Val 
                245                 250                 255     


Phe Lys Lys Tyr Asp Asn Ile Trp Asp Lys Thr Ile Gly Lys Cys Ser 
            260                 265                 270         


Phe Phe Val Glu Glu Asn Arg Ser Pro Val Asn Tyr Pro Ser Tyr Glu 
        275                 280                 285             


Ile Phe Asn Leu Leu Asn Gln Leu Ile Asn Leu Ser Thr Asp Leu Lys 
    290                 295                 300                 


Thr Thr Asn Lys Lys Ile Trp Gln Leu Ser Ser Asn Asp Arg Asn Glu 
305                 310                 315                 320 


Leu Leu Asp Glu Leu Leu Lys Val Lys Glu Lys Ala Lys Ile Ile Ser 
                325                 330                 335     


Ile Ser Leu Lys Lys Asn Glu Ile Lys Lys Ile Ile Leu Lys Asp Phe 
            340                 345                 350         


Gly Phe Glu Lys Ser Asp Ile Asp Asp Gln Asp Thr Ile Glu Gly Arg 
        355                 360                 365             


Lys Ile Ile Lys Glu Glu Pro Thr Thr Lys Leu Glu Val Thr Lys His 
    370                 375                 380                 


Leu Leu Ala Thr Ile Tyr Ser His Ser Ser Asp Ser Asn Trp Ile Asn 
385                 390                 395                 400 


Ile Asn Asn Ile Leu Glu Phe Leu Pro Tyr Leu Asp Ala Ile Cys Ile 
                405                 410                 415     


Ile Leu Asp Arg Glu Lys Ser Arg Gly Gln Asp Glu Val Leu Lys Lys 
            420                 425                 430         


Leu Thr Glu Lys Asn Ile Phe Glu Val Leu Lys Ile Asp Arg Glu Lys 
        435                 440                 445             


Gln Leu Asp Phe Val Lys Ser Ile Phe Ser Asn Thr Lys Phe Asn Phe 
    450                 455                 460                 


Lys Lys Ile Gly Asn Phe Ser Leu Lys Ala Ile Arg Glu Phe Leu Pro 
465                 470                 475                 480 


Lys Met Phe Glu Gln Asn Lys Asn Ser Glu Tyr Leu Lys Trp Lys Asp 
                485                 490                 495     


Glu Glu Ile Arg Arg Lys Trp Glu Glu Gln Lys Ser Lys Leu Gly Lys 
            500                 505                 510         


Thr Asp Lys Lys Thr Lys Tyr Leu Asn Pro Arg Ile Phe Gln Asp Glu 
        515                 520                 525             


Ile Ile Ser Pro Gly Thr Lys Asn Thr Phe Glu Gln Ala Val Leu Val 
    530                 535                 540                 


Leu Asn Gln Ile Ile Lys Lys Tyr Ser Lys Glu Asn Ile Ile Asp Ala 
545                 550                 555                 560 


Ile Ile Ile Glu Ser Pro Arg Glu Lys Asn Asp Lys Lys Thr Ile Glu 
                565                 570                 575     


Glu Ile Lys Lys Arg Asn Lys Lys Gly Lys Gly Lys Thr Leu Glu Lys 
            580                 585                 590         


Leu Phe Gln Ile Leu Asn Leu Glu Asn Lys Gly Tyr Lys Leu Ser Asp 
        595                 600                 605             


Leu Glu Thr Lys Pro Ala Lys Leu Leu Asp Arg Leu Arg Phe Tyr His 
    610                 615                 620                 


Gln Gln Asp Gly Ile Asp Leu Tyr Thr Leu Asp Lys Ile Asn Ile Asp 
625                 630                 635                 640 


Gln Leu Ile Asn Gly Ser Gln Lys Tyr Glu Ile Glu His Ile Ile Pro 
                645                 650                 655     


Tyr Ser Met Ser Tyr Asp Asn Ser Gln Ala Asn Lys Ile Leu Thr Glu 
            660                 665                 670         


Lys Ala Glu Asn Leu Lys Lys Gly Lys Leu Ile Ala Ser Glu Tyr Ile 
        675                 680                 685             


Lys Arg Asn Gly Asp Glu Phe Tyr Asn Lys Tyr Tyr Glu Lys Ala Lys 
    690                 695                 700                 


Glu Leu Phe Ile Asn Lys Tyr Lys Lys Asn Lys Lys Leu Asp Ser Tyr 
705                 710                 715                 720 


Val Asp Leu Asp Glu Asp Ser Ala Lys Asn Arg Phe Arg Phe Leu Thr 
                725                 730                 735     


Leu Gln Asp Tyr Asp Glu Phe Gln Val Glu Phe Leu Ala Arg Asn Leu 
            740                 745                 750         


Asn Asp Thr Arg Tyr Ser Thr Lys Leu Phe Tyr His Ala Leu Val Glu 
        755                 760                 765             


His Phe Glu Asn Asn Glu Phe Phe Thr Tyr Ile Asp Glu Asn Ser Ser 
    770                 775                 780                 


Lys His Lys Val Lys Ile Ser Thr Ile Lys Gly His Val Thr Lys Tyr 
785                 790                 795                 800 


Phe Arg Ala Lys Pro Val Gln Lys Asn Asn Gly Pro Asn Glu Asn Leu 
                805                 810                 815     


Asn Asn Asn Lys Pro Glu Lys Ile Glu Lys Asn Arg Glu Asn Asn Glu 
            820                 825                 830         


His His Ala Val Asp Ala Ala Ile Val Ala Ile Ile Gly Asn Lys Asn 
        835                 840                 845             


Pro Gln Ile Ala Asn Leu Leu Thr Leu Ala Asp Asn Lys Thr Asp Lys 
    850                 855                 860                 


Lys Phe Leu Leu His Asp Glu Asn Tyr Lys Glu Asn Ile Glu Thr Gly 
865                 870                 875                 880 


Glu Leu Val Lys Ile Pro Lys Phe Glu Val Asp Lys Leu Ala Lys Val 
                885                 890                 895     


Glu Asp Leu Lys Lys Ile Ile Gln Glu Lys Tyr Glu Glu Ala Lys Lys 
            900                 905                 910         


His Thr Ala Ile Lys Phe Ser Arg Lys Thr Arg Thr Ile Leu Asn Gly 
        915                 920                 925             


Gly Leu Ser Asp Glu Thr Leu Tyr Gly Phe Lys Tyr Asp Glu Lys Glu 
    930                 935                 940                 


Asp Lys Tyr Phe Lys Ile Ile Lys Lys Lys Leu Val Thr Ser Lys Asn 
945                 950                 955                 960 


Glu Glu Leu Lys Lys Tyr Phe Glu Asn Pro Phe Gly Lys Lys Ala Asp 
                965                 970                 975     


Gly Lys Ser Glu Tyr Thr Val Leu Met Ala Gln Ser His Leu Ser Glu 
            980                 985                 990         


Phe Asn Lys Leu Lys Glu Ile Phe  Glu Lys Tyr Asn Gly  Phe Ser Asn 
        995                 1000                 1005             


Lys Thr  Gly Asn Ala Phe Val  Glu Tyr Met Asn Asp  Leu Ala Leu 
    1010                 1015                 1020             


Lys Glu  Pro Thr Leu Lys Ala  Glu Ile Glu Ser Ala  Lys Ser Val 
    1025                 1030                 1035             


Glu Lys  Leu Leu Tyr Tyr Asn  Phe Lys Pro Ser Asp  Gln Phe Thr 
    1040                 1045                 1050             


Tyr His  Asp Asn Ile Asn Asn  Lys Ser Phe Lys Arg  Phe Tyr Lys 
    1055                 1060                 1065             


Asn Ile  Arg Ile Ile Glu Tyr  Lys Ser Ile Pro Ile  Lys Phe Lys 
    1070                 1075                 1080             


Ile Leu  Ser Lys His Asp Gly  Gly Lys Ser Phe Lys  Asp Thr Leu 
    1085                 1090                 1095             


Phe Ser  Leu Tyr Ser Leu Val  Tyr Lys Val Tyr Glu  Asn Gly Lys 
    1100                 1105                 1110             


Glu Ser  Tyr Lys Ser Ile Pro  Val Thr Ser Gln Met  Arg Asn Phe 
    1115                 1120                 1125             


Gly Ile  Asp Glu Phe Asp Phe  Leu Asp Glu Asn Leu  Tyr Asn Lys 
    1130                 1135                 1140             


Glu Lys  Leu Asp Ile Tyr Lys  Ser Asp Phe Ala Lys  Pro Ile Pro 
    1145                 1150                 1155             


Val Asn  Cys Lys Pro Val Phe  Val Leu Lys Lys Gly  Ser Ile Leu 
    1160                 1165                 1170             


Lys Lys  Lys Ser Leu Asp Ile  Asp Asp Phe Lys Glu  Thr Lys Glu 
    1175                 1180                 1185             


Thr Glu  Glu Gly Asn Tyr Tyr  Phe Ile Ser Thr Ile  Ser Lys Arg 
    1190                 1195                 1200             


Phe Asn  Arg Asp Thr Ala Tyr  Gly Leu Lys Pro Leu  Lys Leu Ser 
    1205                 1210                 1215             


Val Val  Lys Pro Val Ala Glu  Pro Ser Thr Asn Pro  Ile Phe Lys 
    1220                 1225                 1230             


Glu Tyr  Ile Pro Ile His Leu  Asp Glu Leu Gly Asn  Glu Tyr Pro 
    1235                 1240                 1245             


Val Lys  Ile Lys Glu His Thr  Asp Asp Glu Lys Leu  Met Cys Thr 
    1250                 1255                 1260             


Ile Lys  
    1265 


<210>  722
<211>  1233
<212>  PRT
<213>  Mycoplasma canis PG 14

<400>  722

Met Glu Lys Lys Arg Lys Val Thr Leu Gly Phe Asp Leu Gly Ile Ala 
1               5                   10                  15      


Ser Val Gly Trp Ala Ile Val Asp Ser Glu Thr Asn Gln Val Tyr Lys 
            20                  25                  30          


Leu Gly Ser Arg Leu Phe Asp Ala Pro Asp Thr Asn Leu Glu Arg Arg 
        35                  40                  45              


Thr Gln Arg Gly Thr Arg Arg Leu Leu Arg Arg Arg Lys Tyr Arg Asn 
    50                  55                  60                  


Gln Lys Phe Tyr Asn Leu Val Lys Arg Thr Glu Val Phe Gly Leu Ser 
65                  70                  75                  80  


Ser Arg Glu Ala Ile Glu Asn Arg Phe Arg Glu Leu Ser Ile Lys Tyr 
                85                  90                  95      


Pro Asn Ile Ile Glu Leu Lys Thr Lys Ala Leu Ser Gln Glu Val Cys 
            100                 105                 110         


Pro Asp Glu Ile Ala Trp Ile Leu His Asp Tyr Leu Lys Asn Arg Gly 
        115                 120                 125             


Tyr Phe Tyr Asp Glu Lys Glu Thr Lys Glu Asp Phe Asp Gln Gln Thr 
    130                 135                 140                 


Val Glu Ser Met Pro Ser Tyr Lys Leu Asn Glu Phe Tyr Lys Lys Tyr 
145                 150                 155                 160 


Gly Tyr Phe Lys Gly Ala Leu Ser Gln Pro Thr Glu Ser Glu Met Lys 
                165                 170                 175     


Asp Asn Lys Asp Leu Lys Glu Ala Phe Phe Phe Asp Phe Ser Asn Lys 
            180                 185                 190         


Glu Trp Leu Lys Glu Ile Asn Tyr Phe Phe Asn Val Gln Lys Asn Ile 
        195                 200                 205             


Leu Ser Glu Thr Phe Ile Glu Glu Phe Lys Lys Ile Phe Ser Phe Thr 
    210                 215                 220                 


Arg Asp Ile Ser Lys Gly Pro Gly Ser Asp Asn Met Pro Ser Pro Tyr 
225                 230                 235                 240 


Gly Ile Phe Gly Glu Phe Gly Asp Asn Gly Gln Gly Gly Arg Tyr Glu 
                245                 250                 255     


His Ile Trp Asp Lys Asn Ile Gly Lys Cys Ser Ile Phe Thr Asn Glu 
            260                 265                 270         


Gln Arg Ala Pro Lys Tyr Leu Pro Ser Ala Leu Ile Phe Asn Phe Leu 
        275                 280                 285             


Asn Glu Leu Ala Asn Ile Arg Leu Tyr Ser Thr Asp Lys Lys Asn Ile 
    290                 295                 300                 


Gln Pro Leu Trp Lys Leu Ser Ser Val Asp Lys Leu Asn Ile Leu Leu 
305                 310                 315                 320 


Asn Leu Phe Asn Leu Pro Ile Ser Glu Lys Lys Lys Lys Leu Thr Ser 
                325                 330                 335     


Thr Asn Ile Asn Asp Ile Val Lys Lys Glu Ser Ile Lys Ser Ile Met 
            340                 345                 350         


Ile Ser Val Glu Asp Ile Asp Met Ile Lys Asp Glu Trp Ala Gly Lys 
        355                 360                 365             


Glu Pro Asn Val Tyr Gly Val Gly Leu Ser Gly Leu Asn Ile Glu Glu 
    370                 375                 380                 


Ser Ala Lys Glu Asn Lys Phe Lys Phe Gln Asp Leu Lys Ile Leu Asn 
385                 390                 395                 400 


Val Leu Ile Asn Leu Leu Asp Asn Val Gly Ile Lys Phe Glu Phe Lys 
                405                 410                 415     


Asp Arg Asn Asp Ile Ile Lys Asn Leu Glu Leu Leu Asp Asn Leu Tyr 
            420                 425                 430         


Leu Phe Leu Ile Tyr Gln Lys Glu Ser Asn Asn Lys Asp Ser Ser Ile 
        435                 440                 445             


Asp Leu Phe Ile Ala Lys Asn Glu Ser Leu Asn Ile Glu Asn Leu Lys 
    450                 455                 460                 


Leu Lys Leu Lys Glu Phe Leu Leu Gly Ala Gly Asn Glu Phe Glu Asn 
465                 470                 475                 480 


His Asn Ser Lys Thr His Ser Leu Ser Lys Lys Ala Ile Asp Glu Ile 
                485                 490                 495     


Leu Pro Lys Leu Leu Asp Asn Asn Glu Gly Trp Asn Leu Glu Ala Ile 
            500                 505                 510         


Lys Asn Tyr Asp Glu Glu Ile Lys Ser Gln Ile Glu Asp Asn Ser Ser 
        515                 520                 525             


Leu Met Ala Lys Gln Asp Lys Lys Tyr Leu Asn Asp Asn Phe Leu Lys 
    530                 535                 540                 


Asp Ala Ile Leu Pro Pro Asn Val Lys Val Thr Phe Gln Gln Ala Ile 
545                 550                 555                 560 


Leu Ile Phe Asn Lys Ile Ile Gln Lys Phe Ser Lys Asp Phe Glu Ile 
                565                 570                 575     


Asp Lys Val Val Ile Glu Leu Ala Arg Glu Met Thr Gln Asp Gln Glu 
            580                 585                 590         


Asn Asp Ala Leu Lys Gly Ile Ala Lys Ala Gln Lys Ser Lys Lys Ser 
        595                 600                 605             


Leu Val Glu Glu Arg Leu Glu Ala Asn Asn Ile Asp Lys Ser Val Phe 
    610                 615                 620                 


Asn Asp Lys Tyr Glu Lys Leu Ile Tyr Lys Ile Phe Leu Trp Ile Ser 
625                 630                 635                 640 


Gln Asp Phe Lys Asp Pro Tyr Thr Gly Ala Gln Ile Ser Val Asn Glu 
                645                 650                 655     


Ile Val Asn Asn Lys Val Glu Ile Asp His Ile Ile Pro Tyr Ser Leu 
            660                 665                 670         


Cys Phe Asp Asp Ser Ser Ala Asn Lys Val Leu Val His Lys Gln Ser 
        675                 680                 685             


Asn Gln Glu Lys Ser Asn Ser Leu Pro Tyr Glu Tyr Ile Lys Gln Gly 
    690                 695                 700                 


His Ser Gly Trp Asn Trp Asp Glu Phe Thr Lys Tyr Val Lys Arg Val 
705                 710                 715                 720 


Phe Val Asn Asn Val Asp Ser Ile Leu Ser Lys Lys Glu Arg Leu Lys 
                725                 730                 735     


Lys Ser Glu Asn Leu Leu Thr Ala Ser Tyr Asp Gly Tyr Asp Lys Leu 
            740                 745                 750         


Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Leu 
        755                 760                 765             


Phe Arg Asp Gln Leu Asn Asn Tyr Ala Glu His His Leu Ile Asp Asn 
    770                 775                 780                 


Lys Lys Met Phe Lys Val Ile Ala Met Asn Gly Ala Val Thr Ser Phe 
785                 790                 795                 800 


Ile Arg Lys Asn Met Ser Tyr Asp Asn Lys Leu Arg Leu Lys Asp Arg 
                805                 810                 815     


Ser Asp Phe Ser His His Ala Tyr Asp Ala Ala Ile Ile Ala Leu Phe 
            820                 825                 830         


Ser Asn Lys Thr Lys Thr Leu Tyr Asn Leu Ile Asp Pro Ser Leu Asn 
        835                 840                 845             


Gly Ile Ile Ser Lys Arg Ser Glu Gly Tyr Trp Val Ile Glu Asp Arg 
    850                 855                 860                 


Tyr Thr Gly Glu Ile Lys Glu Leu Lys Lys Glu Asp Trp Thr Ser Ile 
865                 870                 875                 880 


Lys Asn Asn Val Gln Ala Arg Lys Ile Ala Lys Glu Ile Glu Glu Tyr 
                885                 890                 895     


Leu Ile Asp Leu Asp Asp Glu Val Phe Phe Ser Arg Lys Thr Lys Arg 
            900                 905                 910         


Lys Thr Asn Arg Gln Leu Tyr Asn Glu Thr Ile Tyr Gly Ile Ala Thr 
        915                 920                 925             


Lys Thr Asp Glu Asp Gly Ile Thr Asn Tyr Tyr Lys Lys Glu Lys Phe 
    930                 935                 940                 


Ser Ile Leu Asp Asp Lys Asp Ile Tyr Leu Arg Leu Leu Arg Glu Arg 
945                 950                 955                 960 


Glu Lys Phe Val Ile Asn Gln Ser Asn Pro Glu Val Ile Asp Gln Ile 
                965                 970                 975     


Ile Glu Ile Ile Glu Ser Tyr Gly Lys Glu Asn Asn Ile Pro Ser Arg 
            980                 985                 990         


Asp Glu Ala Ile Asn Ile Lys Tyr  Thr Lys Asn Lys Ile  Asn Tyr Asn 
        995                 1000                 1005             


Leu Tyr  Leu Lys Gln Tyr Met  Arg Ser Leu Thr Lys  Ser Leu Asp 
    1010                 1015                 1020             


Gln Phe  Ser Glu Glu Phe Ile  Asn Gln Met Ile Ala  Asn Lys Thr 
    1025                 1030                 1035             


Phe Val  Leu Tyr Asn Pro Thr  Lys Asn Thr Thr Arg  Lys Ile Lys 
    1040                 1045                 1050             


Phe Leu  Arg Leu Val Asn Asp  Val Lys Ile Asn Asp  Ile Arg Lys 
    1055                 1060                 1065             


Asn Gln  Val Ile Asn Lys Phe  Asn Gly Lys Asn Asn  Glu Pro Lys 
    1070                 1075                 1080             


Ala Phe  Tyr Glu Asn Ile Asn  Ser Leu Gly Ala Ile  Val Phe Lys 
    1085                 1090                 1095             


Asn Ser  Ala Asn Asn Phe Lys  Thr Leu Ser Ile Asn  Thr Gln Ile 
    1100                 1105                 1110             


Ala Ile  Phe Gly Asp Lys Asn  Trp Asp Ile Glu Asp  Phe Lys Thr 
    1115                 1120                 1125             


Tyr Asn  Met Glu Lys Ile Glu  Lys Tyr Lys Glu Ile  Tyr Gly Ile 
    1130                 1135                 1140             


Asp Lys  Thr Tyr Asn Phe His  Ser Phe Ile Phe Pro  Gly Thr Ile 
    1145                 1150                 1155             


Leu Leu  Asp Lys Gln Asn Lys  Glu Phe Tyr Tyr Ile  Ser Ser Ile 
    1160                 1165                 1170             


Gln Thr  Val Arg Asp Ile Ile  Glu Ile Lys Phe Leu  Asn Lys Ile 
    1175                 1180                 1185             


Glu Phe  Lys Asp Glu Asn Lys  Asn Gln Asp Thr Ser  Lys Thr Pro 
    1190                 1195                 1200             


Lys Arg  Leu Met Phe Gly Ile  Lys Ser Ile Met Asn  Asn Tyr Glu 
    1205                 1210                 1215             


Gln Val  Asp Ile Ser Pro Phe  Gly Ile Asn Lys Lys  Ile Phe Glu 
    1220                 1225                 1230             


<210>  723
<211>  1304
<212>  PRT
<213>  Mycoplasma synoviae 53

<400>  723

Met Leu Asn Asn Val Gln Asn Leu Trp Lys Tyr Leu Leu Leu Leu Ile 
1               5                   10                  15      


Phe Asp Lys Lys Ile Ile Phe Leu Phe Lys Ile Lys Val Ile Leu Ile 
            20                  25                  30          


Arg Arg Tyr Met Glu Asn Asn Asn Lys Glu Lys Ile Val Ile Gly Phe 
        35                  40                  45              


Asp Leu Gly Val Ala Ser Val Gly Trp Ser Ile Val Asn Ala Glu Thr 
    50                  55                  60                  


Lys Glu Val Ile Asp Leu Gly Val Arg Leu Phe Ser Glu Pro Glu Lys 
65                  70                  75                  80  


Ala Asp Tyr Arg Arg Ala Lys Arg Thr Thr Arg Arg Leu Leu Arg Arg 
                85                  90                  95      


Lys Lys Phe Lys Arg Glu Lys Phe His Lys Leu Ile Leu Lys Asn Ala 
            100                 105                 110         


Glu Ile Phe Gly Leu Gln Ser Arg Asn Glu Ile Leu Asn Val Tyr Lys 
        115                 120                 125             


Asp Gln Ser Ser Lys Tyr Arg Asn Ile Leu Lys Leu Lys Ile Asn Ala 
    130                 135                 140                 


Leu Lys Glu Glu Ile Lys Pro Ser Glu Leu Val Trp Ile Leu Arg Asp 
145                 150                 155                 160 


Tyr Leu Gln Asn Arg Gly Tyr Phe Tyr Lys Asn Glu Lys Leu Thr Asp 
                165                 170                 175     


Glu Phe Val Ser Asn Ser Phe Pro Ser Lys Lys Leu His Glu His Tyr 
            180                 185                 190         


Glu Lys Tyr Gly Phe Phe Arg Gly Ser Val Lys Leu Asp Asn Lys Leu 
        195                 200                 205             


Asp Asn Lys Lys Asp Lys Ala Lys Glu Lys Asp Glu Glu Glu Glu Ser 
    210                 215                 220                 


Asp Ala Lys Lys Glu Ser Glu Glu Leu Ile Phe Ser Asn Lys Gln Trp 
225                 230                 235                 240 


Ile Asn Glu Ile Val Lys Val Phe Glu Asn Gln Ser Tyr Leu Thr Glu 
                245                 250                 255     


Ser Phe Lys Glu Glu Tyr Leu Lys Leu Phe Asn Tyr Val Arg Pro Phe 
            260                 265                 270         


Asn Lys Gly Pro Gly Ser Lys Asn Ser Arg Thr Ala Tyr Gly Val Phe 
        275                 280                 285             


Ser Thr Asp Ile Asp Pro Glu Thr Asn Lys Phe Lys Asp Tyr Ser Asn 
    290                 295                 300                 


Ile Trp Asp Lys Thr Ile Gly Lys Cys Ser Leu Phe Glu Glu Glu Ile 
305                 310                 315                 320 


Arg Ala Pro Lys Asn Leu Pro Ser Ala Leu Ile Phe Asn Leu Gln Asn 
                325                 330                 335     


Glu Ile Cys Thr Ile Lys Asn Glu Phe Thr Glu Phe Lys Asn Trp Trp 
            340                 345                 350         


Leu Asn Ala Glu Gln Lys Ser Glu Ile Leu Lys Phe Val Phe Thr Glu 
        355                 360                 365             


Leu Phe Asn Trp Lys Asp Lys Lys Tyr Ser Asp Lys Lys Phe Asn Lys 
    370                 375                 380                 


Asn Leu Gln Asp Lys Ile Lys Lys Tyr Leu Leu Asn Phe Ala Leu Glu 
385                 390                 395                 400 


Asn Phe Asn Leu Asn Glu Glu Ile Leu Lys Asn Arg Asp Leu Glu Asn 
                405                 410                 415     


Asp Thr Val Leu Gly Leu Lys Gly Val Lys Tyr Tyr Glu Lys Ser Asn 
            420                 425                 430         


Ala Thr Ala Asp Ala Ala Leu Glu Phe Ser Ser Leu Lys Pro Leu Tyr 
        435                 440                 445             


Val Phe Ile Lys Phe Leu Lys Glu Lys Lys Leu Asp Leu Asn Tyr Leu 
    450                 455                 460                 


Leu Gly Leu Glu Asn Thr Glu Ile Leu Tyr Phe Leu Asp Ser Ile Tyr 
465                 470                 475                 480 


Leu Ala Ile Ser Tyr Ser Ser Asp Leu Lys Glu Arg Asn Glu Trp Phe 
                485                 490                 495     


Lys Lys Leu Leu Lys Glu Leu Tyr Pro Lys Ile Lys Asn Asn Asn Leu 
            500                 505                 510         


Glu Ile Ile Glu Asn Val Glu Asp Ile Phe Glu Ile Thr Asp Gln Glu 
        515                 520                 525             


Lys Phe Glu Ser Phe Ser Lys Thr His Ser Leu Ser Arg Glu Ala Phe 
    530                 535                 540                 


Asn His Ile Ile Pro Leu Leu Leu Ser Asn Asn Glu Gly Lys Asn Tyr 
545                 550                 555                 560 


Glu Ser Leu Lys His Ser Asn Glu Glu Leu Lys Lys Arg Thr Glu Lys 
                565                 570                 575     


Ala Glu Leu Lys Ala Gln Gln Asn Gln Lys Tyr Leu Lys Asp Asn Phe 
            580                 585                 590         


Leu Lys Glu Ala Leu Val Pro Leu Ser Val Lys Thr Ser Val Leu Gln 
        595                 600                 605             


Ala Ile Lys Ile Phe Asn Gln Ile Ile Lys Asn Phe Gly Lys Lys Tyr 
    610                 615                 620                 


Glu Ile Ser Gln Val Val Ile Glu Met Ala Arg Glu Leu Thr Lys Pro 
625                 630                 635                 640 


Asn Leu Glu Lys Leu Leu Asn Asn Ala Thr Asn Ser Asn Ile Lys Ile 
                645                 650                 655     


Leu Lys Glu Lys Leu Asp Gln Thr Glu Lys Phe Asp Asp Phe Thr Lys 
            660                 665                 670         


Lys Lys Phe Ile Asp Lys Ile Glu Asn Ser Val Val Phe Arg Asn Lys 
        675                 680                 685             


Leu Phe Leu Trp Phe Glu Gln Asp Arg Lys Asp Pro Tyr Thr Gln Leu 
    690                 695                 700                 


Asp Ile Lys Ile Asn Glu Ile Glu Asp Glu Thr Glu Ile Asp His Val 
705                 710                 715                 720 


Ile Pro Tyr Ser Lys Ser Ala Asp Asp Ser Trp Phe Asn Lys Leu Leu 
                725                 730                 735     


Val Lys Lys Ser Thr Asn Gln Leu Lys Lys Asn Lys Thr Val Trp Glu 
            740                 745                 750         


Tyr Tyr Gln Asn Glu Ser Asp Pro Glu Ala Lys Trp Asn Lys Phe Val 
        755                 760                 765             


Ala Trp Ala Lys Arg Ile Tyr Leu Val Gln Lys Ser Asp Lys Glu Ser 
    770                 775                 780                 


Lys Asp Asn Ser Glu Lys Asn Ser Ile Phe Lys Asn Lys Lys Pro Asn 
785                 790                 795                 800 


Leu Lys Phe Lys Asn Ile Thr Lys Lys Leu Phe Asp Pro Tyr Lys Asp 
                805                 810                 815     


Leu Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Lys 
            820                 825                 830         


Val Phe Arg Asp Gln Leu Asn Asn Tyr Ser Lys His His Ser Lys Asp 
        835                 840                 845             


Asp Glu Asn Lys Leu Phe Lys Val Val Cys Met Asn Gly Ser Ile Thr 
    850                 855                 860                 


Ser Phe Leu Arg Lys Ser Met Trp Arg Lys Asn Glu Glu Gln Val Tyr 
865                 870                 875                 880 


Arg Phe Asn Phe Trp Lys Lys Asp Arg Asp Gln Phe Phe His His Ala 
                885                 890                 895     


Val Asp Ala Ser Ile Ile Ala Ile Phe Ser Leu Leu Thr Lys Thr Leu 
            900                 905                 910         


Tyr Asn Lys Leu Arg Val Tyr Glu Ser Tyr Asp Val Gln Arg Arg Glu 
        915                 920                 925             


Asp Gly Val Tyr Leu Ile Asn Lys Glu Thr Gly Glu Val Lys Lys Ala 
    930                 935                 940                 


Asp Lys Asp Tyr Trp Lys Asp Gln His Asn Phe Leu Lys Ile Arg Glu 
945                 950                 955                 960 


Asn Ala Ile Glu Ile Lys Asn Val Leu Asn Asn Val Asp Phe Gln Asn 
                965                 970                 975     


Gln Val Arg Tyr Ser Arg Lys Ala Asn Thr Lys Leu Asn Thr Gln Leu 
            980                 985                 990         


Phe Asn Glu Thr Leu Tyr Gly Val  Lys Glu Phe Glu Asn  Asn Phe Tyr 
        995                 1000                 1005             


Lys Leu  Glu Lys Val Asn Leu  Phe Ser Arg Lys Asp  Leu Arg Lys 
    1010                 1015                 1020             


Phe Ile  Leu Glu Asp Leu Asn  Glu Glu Ser Glu Lys  Asn Lys Lys 
    1025                 1030                 1035             


Asn Glu  Asn Gly Ser Arg Lys  Arg Ile Leu Thr Glu  Lys Tyr Ile 
    1040                 1045                 1050             


Val Asp  Glu Ile Leu Gln Ile  Leu Glu Asn Glu Glu  Phe Lys Asp 
    1055                 1060                 1065             


Ser Lys  Ser Asp Ile Asn Ala  Leu Asn Lys Tyr Met  Asp Ser Leu 
    1070                 1075                 1080             


Pro Ser  Lys Phe Ser Glu Phe  Phe Ser Gln Asp Phe  Ile Asn Lys 
    1085                 1090                 1095             


Cys Lys  Lys Glu Asn Ser Leu  Ile Leu Thr Phe Asp  Ala Ile Lys 
    1100                 1105                 1110             


His Asn  Asp Pro Lys Lys Val  Ile Lys Ile Lys Asn  Leu Lys Phe 
    1115                 1120                 1125             


Phe Arg  Glu Asp Ala Thr Leu  Lys Asn Lys Gln Ala  Val His Lys 
    1130                 1135                 1140             


Asp Ser  Lys Asn Gln Ile Lys  Ser Phe Tyr Glu Ser  Tyr Lys Cys 
    1145                 1150                 1155             


Val Gly  Phe Ile Trp Leu Lys  Asn Lys Asn Asp Leu  Glu Glu Ser 
    1160                 1165                 1170             


Ile Phe  Val Pro Ile Asn Ser  Arg Val Ile His Phe  Gly Asp Lys 
    1175                 1180                 1185             


Asp Lys  Asp Ile Phe Asp Phe  Asp Ser Tyr Asn Lys  Glu Lys Leu 
    1190                 1195                 1200             


Leu Asn  Glu Ile Asn Leu Lys  Arg Pro Glu Asn Lys  Lys Phe Asn 
    1205                 1210                 1215             


Ser Ile  Asn Glu Ile Glu Phe  Val Lys Phe Val Lys  Pro Gly Ala 
    1220                 1225                 1230             


Leu Leu  Leu Asn Phe Glu Asn  Gln Gln Ile Tyr Tyr  Ile Ser Thr 
    1235                 1240                 1245             


Leu Glu  Ser Ser Ser Leu Arg  Ala Lys Ile Lys Leu  Leu Asn Lys 
    1250                 1255                 1260             


Met Asp  Lys Gly Lys Ala Val  Ser Met Lys Lys Ile  Thr Asn Pro 
    1265                 1270                 1275             


Asp Glu  Tyr Lys Ile Ile Glu  His Val Asn Pro Leu  Gly Ile Asn 
    1280                 1285                 1290             


Leu Asn  Trp Thr Lys Lys Leu  Glu Asn Asn Asn 
    1295                 1300                 


<210>  724
<211>  1114
<212>  PRT
<213>  Eubacterium rectale ATCC 33656

<400>  724

Met Asn Tyr Thr Glu Lys Glu Lys Leu Phe Met Lys Tyr Ile Leu Ala 
1               5                   10                  15      


Leu Asp Ile Gly Ile Ala Ser Val Gly Trp Ala Ile Leu Asp Lys Glu 
            20                  25                  30          


Ser Glu Thr Val Ile Glu Ala Gly Ser Asn Ile Phe Pro Glu Ala Ser 
        35                  40                  45              


Ala Ala Asp Asn Gln Leu Arg Arg Asp Met Arg Gly Ala Lys Arg Asn 
    50                  55                  60                  


Asn Arg Arg Leu Lys Thr Arg Ile Asn Asp Phe Ile Lys Leu Trp Glu 
65                  70                  75                  80  


Asn Asn Asn Leu Ser Ile Pro Gln Phe Lys Ser Thr Glu Ile Val Gly 
                85                  90                  95      


Leu Lys Val Arg Ala Ile Thr Glu Glu Ile Thr Leu Asp Glu Leu Tyr 
            100                 105                 110         


Leu Ile Leu Tyr Ser Tyr Leu Lys His Arg Gly Ile Ser Tyr Leu Glu 
        115                 120                 125             


Asp Ala Leu Asp Asp Thr Val Ser Gly Ser Ser Ala Tyr Ala Asn Gly 
    130                 135                 140                 


Leu Lys Leu Asn Ala Lys Glu Leu Glu Thr His Tyr Pro Cys Glu Ile 
145                 150                 155                 160 


Gln Gln Glu Arg Leu Asn Thr Ile Gly Lys Tyr Arg Gly Gln Ser Gln 
                165                 170                 175     


Ile Ile Asn Glu Asn Gly Glu Val Leu Asp Leu Ser Asn Val Phe Thr 
            180                 185                 190         


Ile Gly Ala Tyr Arg Lys Glu Ile Gln Arg Val Phe Glu Ile Gln Lys 
        195                 200                 205             


Lys Tyr His Pro Glu Leu Thr Asp Glu Phe Cys Asp Gly Tyr Met Leu 
    210                 215                 220                 


Ile Phe Asn Arg Lys Arg Lys Tyr Tyr Glu Gly Pro Gly Asn Glu Lys 
225                 230                 235                 240 


Ser Arg Thr Asp Tyr Gly Arg Phe Thr Thr Lys Leu Asp Ala Asn Gly 
                245                 250                 255     


Asn Tyr Ile Thr Glu Asp Asn Ile Phe Glu Lys Leu Ile Gly Lys Cys 
            260                 265                 270         


Ser Val Tyr Pro Asp Glu Leu Arg Ala Ala Ala Ala Ser Tyr Thr Ala 
        275                 280                 285             


Gln Glu Tyr Asn Val Leu Asn Asp Leu Asn Asn Leu Thr Ile Asn Gly 
    290                 295                 300                 


Arg Lys Leu Glu Glu Asn Glu Lys His Glu Ile Val Glu Arg Ile Lys 
305                 310                 315                 320 


Ser Ser Asn Thr Ile Asn Met Arg Lys Ile Ile Ser Asp Cys Met Gly 
                325                 330                 335     


Glu Asn Ile Asp Asp Phe Ala Gly Ala Arg Ile Asp Lys Ser Gly Lys 
            340                 345                 350         


Glu Ile Phe His Lys Phe Glu Val Tyr Asn Lys Met Arg Lys Ala Leu 
        355                 360                 365             


Leu Glu Ile Gly Ile Asp Ile Ser Asn Tyr Ser Arg Glu Glu Leu Asp 
    370                 375                 380                 


Glu Ile Gly Tyr Ile Met Thr Ile Asn Thr Asp Lys Glu Ala Met Met 
385                 390                 395                 400 


Glu Ala Phe Gln Lys Ser Trp Ile Asp Leu Ser Asp Asp Val Lys Gln 
                405                 410                 415     


Cys Leu Ile Asn Met Arg Lys Thr Asn Gly Ala Leu Phe Asn Lys Trp 
            420                 425                 430         


Gln Ser Phe Ser Leu Lys Ile Met Asn Glu Leu Ile Pro Glu Met Tyr 
        435                 440                 445             


Ala Gln Pro Lys Glu Gln Met Thr Leu Leu Thr Glu Met Gly Val Thr 
    450                 455                 460                 


Lys Gly Thr Gln Glu Glu Phe Ala Gly Leu Lys Tyr Ile Pro Val Asp 
465                 470                 475                 480 


Val Val Ser Glu Asp Ile Phe Asn Pro Val Val Arg Arg Ser Val Arg 
                485                 490                 495     


Ile Ser Phe Lys Ile Leu Asn Ala Val Leu Lys Lys Tyr Lys Ala Leu 
            500                 505                 510         


Asp Thr Ile Val Ile Glu Met Pro Arg Asp Arg Asn Ser Glu Glu Gln 
        515                 520                 525             


Lys Lys Arg Ile Asn Asp Ser Gln Lys Leu Asn Glu Lys Glu Met Glu 
    530                 535                 540                 


Tyr Ile Glu Lys Lys Leu Ala Val Thr Tyr Gly Ile Lys Leu Ser Pro 
545                 550                 555                 560 


Ser Asp Phe Ser Ser Gln Lys Gln Leu Ser Leu Lys Leu Lys Leu Trp 
                565                 570                 575     


Asn Glu Gln Asp Gly Ile Cys Leu Tyr Ser Gly Lys Thr Ile Asp Pro 
            580                 585                 590         


Asn Asp Ile Ile Asn Asn Pro Gln Leu Phe Glu Ile Asp His Ile Ile 
        595                 600                 605             


Pro Arg Ser Ile Ser Phe Asp Asp Ala Arg Ser Asn Lys Val Leu Val 
    610                 615                 620                 


Tyr Arg Ser Glu Asn Gln Lys Lys Gly Asn Gln Thr Pro Tyr Tyr Tyr 
625                 630                 635                 640 


Leu Thr His Ser His Ser Glu Trp Ser Phe Glu Gln Tyr Lys Ala Thr 
                645                 650                 655     


Val Met Asn Leu Ser Lys Lys Lys Glu Tyr Ala Ile Ser Arg Lys Lys 
            660                 665                 670         


Ile Gln Asn Leu Leu Tyr Ser Glu Asp Ile Thr Lys Met Asp Val Leu 
        675                 680                 685             


Lys Gly Phe Ile Asn Arg Asn Ile Asn Asp Thr Ser Tyr Ala Ser Arg 
    690                 695                 700                 


Leu Val Leu Asn Thr Ile Gln Asn Phe Phe Met Ala Asn Glu Ala Asp 
705                 710                 715                 720 


Thr Lys Val Lys Val Ile Lys Gly Ser Tyr Thr His Gln Met Arg Cys 
                725                 730                 735     


Asn Leu Lys Leu Asp Lys Asn Arg Asp Glu Ser Tyr Ser His His Ala 
            740                 745                 750         


Val Asp Ala Met Leu Ile Gly Tyr Ser Glu Leu Gly Tyr Glu Ala Tyr 
        755                 760                 765             


His Lys Leu Gln Gly Glu Phe Ile Asp Phe Glu Thr Gly Glu Ile Leu 
    770                 775                 780                 


Arg Lys Asp Met Trp Asp Glu Asn Met Ser Asp Glu Val Tyr Ala Asp 
785                 790                 795                 800 


Tyr Leu Tyr Gly Lys Lys Trp Ala Asn Ile Arg Asn Glu Val Val Lys 
                805                 810                 815     


Ala Glu Lys Asn Val Lys Tyr Trp His Tyr Val Met Arg Lys Ser Asn 
            820                 825                 830         


Arg Gly Leu Cys Asn Gln Thr Ile Arg Gly Thr Arg Glu Tyr Asp Gly 
        835                 840                 845             


Lys Gln Tyr Lys Ile Asn Lys Leu Asp Ile Arg Thr Lys Glu Gly Ile 
    850                 855                 860                 


Lys Val Phe Ala Lys Leu Ala Phe Ser Lys Lys Asp Ser Asp Arg Glu 
865                 870                 875                 880 


Arg Leu Leu Val Tyr Leu Asn Asp Arg Arg Thr Phe Asp Asp Leu Cys 
                885                 890                 895     


Lys Ile Tyr Glu Asp Tyr Ser Asp Ala Ala Asn Pro Phe Val Gln Tyr 
            900                 905                 910         


Glu Lys Glu Thr Gly Asp Ile Ile Arg Lys Tyr Ser Lys Lys His Asn 
        915                 920                 925             


Gly Pro Arg Ile Asp Lys Leu Lys Tyr Lys Asp Gly Glu Val Gly Ala 
    930                 935                 940                 


Cys Ile Asp Ile Ser His Lys Tyr Gly Phe Glu Lys Gly Ser Lys Lys 
945                 950                 955                 960 


Val Ile Leu Glu Ser Leu Val Pro Tyr Arg Met Asp Val Tyr Tyr Lys 
                965                 970                 975     


Glu Glu Asn His Ser Tyr Tyr Leu Val Gly Val Lys Gln Ser Asp Ile 
            980                 985                 990         


Lys Phe Glu Lys Gly Arg Asn Val  Ile Asp Glu Glu Ala  Tyr Ala Arg 
        995                 1000                 1005             


Ile Leu  Val Asn Glu Lys Met  Ile Gln Pro Gly Gln  Ser Arg Ala 
    1010                 1015                 1020             


Asp Leu  Glu Asn Leu Gly Phe  Lys Phe Lys Leu Ser  Phe Tyr Lys 
    1025                 1030                 1035             


Asn Asp  Ile Ile Glu Tyr Glu  Lys Asp Gly Lys Ile  Tyr Thr Glu 
    1040                 1045                 1050             


Arg Leu  Val Ser Arg Thr Met  Pro Lys Gln Arg Asn  Tyr Ile Glu 
    1055                 1060                 1065             


Thr Lys  Pro Ile Asp Lys Ala  Lys Phe Glu Lys Gln  Asn Leu Val 
    1070                 1075                 1080             


Gly Leu  Gly Lys Thr Lys Phe  Ile Lys Lys Tyr Arg  Tyr Asp Ile 
    1085                 1090                 1095             


Leu Gly  Asn Lys Tyr Ser Cys  Ser Glu Glu Lys Phe  Thr Ser Phe 
    1100                 1105                 1110             


Cys 
    


<210>  725
<211>  1121
<212>  PRT
<213>  Streptococcus thermophilus LMD-9

<400>  725

Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Ala Arg Arg Lys Lys His Arg Arg Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr Thr Ser Ser Ser Asn Lys 
    450                 455                 460                 


Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Val Asn Ala Ala 
                485                 490                 495     


Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 
            500                 505                 510         


Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Lys Ile Gln Lys 
        515                 520                 525             


Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gln 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Ser 
            580                 585                 590         


Asn Gln Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp Asp Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 
                645                 650                 655     


Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 
            660                 665                 670         


Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gln Glu His Phe Arg Ala 
    690                 695                 700                 


His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Asn 
            740                 745                 750         


Leu Trp Lys Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser Glu Asp Gln 
        755                 760                 765             


Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 
    770                 775                 780                 


Glu Ser Val Phe Lys Ala Pro Tyr Gln His Phe Val Asp Thr Leu Lys 
785                 790                 795                 800 


Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp Ser 
                805                 810                 815     


Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gln 
            820                 825                 830         


Ala Lys Val Gly Lys Asp Lys Ala Asp Glu Thr Tyr Val Leu Gly Lys 
        835                 840                 845             


Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr Asp Ala Phe Met Lys Ile 
    850                 855                 860                 


Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro Gln 
865                 870                 875                 880 


Thr Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn Tyr Pro Asn Lys 
                885                 890                 895     


Gln Ile Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro Phe Leu Lys 
            900                 905                 910         


Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys Tyr Ser Lys Lys Gly Asn 
        915                 920                 925             


Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Ser Lys Leu Gly Asn 
    930                 935                 940                 


His Ile Asp Ile Thr Pro Lys Asp Ser Asn Asn Lys Val Val Leu Gln 
945                 950                 955                 960 


Ser Val Ser Pro Trp Arg Ala Asp Val Tyr Phe Asn Lys Thr Thr Gly 
                965                 970                 975     


Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ala Asp Leu Gln Phe Glu Lys 
            980                 985                 990         


Gly Thr Gly Thr Tyr Lys Ile Ser  Gln Glu Lys Tyr Asn  Asp Ile Lys 
        995                 1000                 1005             


Lys Lys  Glu Gly Val Asp Ser  Asp Ser Glu Phe Lys  Phe Thr Leu 
    1010                 1015                 1020             


Tyr Lys  Asn Asp Leu Leu Leu  Val Lys Asp Thr Glu  Thr Lys Glu 
    1025                 1030                 1035             


Gln Gln  Leu Phe Arg Phe Leu  Ser Arg Thr Met Pro  Lys Gln Lys 
    1040                 1045                 1050             


His Tyr  Val Glu Leu Lys Pro  Tyr Asp Lys Gln Lys  Phe Glu Gly 
    1055                 1060                 1065             


Gly Glu  Ala Leu Ile Lys Val  Leu Gly Asn Val Ala  Asn Ser Gly 
    1070                 1075                 1080             


Gln Cys  Lys Lys Gly Leu Gly  Lys Ser Asn Ile Ser  Ile Tyr Lys 
    1085                 1090                 1095             


Val Arg  Thr Asp Val Leu Gly  Asn Gln His Ile Ile  Lys Asn Glu 
    1100                 1105                 1110             


Gly Asp  Lys Pro Lys Leu Asp  Phe 
    1115                 1120     


<210>  726
<211>  1150
<212>  PRT
<213>  Enterococcus faecalis TX0012

<400>  726

Met Tyr Ser Ile Gly Leu Asp Leu Gly Ile Ser Ser Val Gly Trp Ser 
1               5                   10                  15      


Val Ile Asp Glu Arg Thr Gly Asn Val Ile Asp Leu Gly Val Arg Leu 
            20                  25                  30          


Phe Ser Ala Lys Asn Ser Glu Lys Asn Leu Glu Arg Arg Thr Asn Arg 
        35                  40                  45              


Gly Gly Arg Arg Leu Ile Arg Arg Lys Thr Asn Arg Leu Lys Asp Ala 
    50                  55                  60                  


Lys Lys Ile Leu Ala Ala Val Gly Phe Tyr Glu Asp Lys Ser Leu Lys 
65                  70                  75                  80  


Asn Ser Cys Pro Tyr Gln Leu Arg Val Lys Gly Leu Thr Glu Pro Leu 
                85                  90                  95      


Ser Arg Gly Glu Ile Tyr Lys Val Thr Leu His Ile Leu Lys Lys Arg 
            100                 105                 110         


Gly Ile Ser Tyr Leu Asp Glu Val Asp Thr Glu Ala Ala Lys Glu Ser 
        115                 120                 125             


Gln Asp Tyr Lys Glu Gln Val Arg Lys Asn Ala Gln Leu Leu Thr Lys 
    130                 135                 140                 


Tyr Thr Pro Gly Gln Ile Gln Leu Gln Arg Leu Lys Glu Asn Asn Arg 
145                 150                 155                 160 


Val Lys Thr Gly Ile Asn Ala Gln Gly Asn Tyr Gln Leu Asn Val Phe 
                165                 170                 175     


Lys Val Ser Ala Tyr Ala Asn Glu Leu Ala Thr Ile Leu Lys Thr Gln 
            180                 185                 190         


Gln Ala Phe Tyr Pro Asn Glu Leu Thr Asp Asp Trp Ile Ala Leu Phe 
        195                 200                 205             


Val Gln Pro Gly Ile Ala Glu Glu Ala Gly Leu Ile Tyr Arg Lys Arg 
    210                 215                 220                 


Pro Tyr Tyr His Gly Pro Gly Asn Glu Ala Asn Asn Ser Pro Tyr Gly 
225                 230                 235                 240 


Arg Trp Ser Asp Phe Gln Lys Thr Gly Glu Pro Ala Thr Asn Ile Phe 
                245                 250                 255     


Asp Lys Leu Ile Gly Lys Asp Phe Gln Gly Glu Leu Arg Ala Ser Gly 
            260                 265                 270         


Leu Ser Leu Ser Ala Gln Gln Tyr Asn Leu Leu Asn Asp Leu Thr Asn 
        275                 280                 285             


Leu Lys Ile Asp Gly Glu Val Pro Leu Ser Ser Glu Gln Lys Glu Tyr 
    290                 295                 300                 


Ile Leu Thr Glu Leu Met Thr Lys Glu Phe Thr Arg Phe Gly Val Asn 
305                 310                 315                 320 


Asp Val Val Lys Leu Leu Gly Val Lys Lys Glu Arg Leu Ser Gly Trp 
                325                 330                 335     


Arg Leu Asp Lys Lys Gly Lys Pro Glu Ile His Thr Leu Lys Gly Tyr 
            340                 345                 350         


Arg Asn Trp Arg Lys Ile Phe Ala Glu Ala Gly Ile Asp Leu Ala Thr 
        355                 360                 365             


Leu Pro Thr Glu Thr Ile Asp Cys Leu Ala Lys Val Leu Thr Leu Asn 
    370                 375                 380                 


Thr Glu Arg Glu Gly Ile Glu Asn Thr Leu Ala Phe Glu Leu Pro Glu 
385                 390                 395                 400 


Leu Ser Glu Ser Val Lys Leu Leu Val Leu Asp Arg Tyr Lys Glu Leu 
                405                 410                 415     


Ser Gln Ser Ile Ser Thr Gln Ser Trp His Arg Phe Ser Leu Lys Thr 
            420                 425                 430         


Leu His Leu Leu Ile Pro Glu Leu Met Asn Ala Thr Ser Glu Gln Asn 
        435                 440                 445             


Thr Leu Leu Glu Gln Phe Gln Leu Lys Ser Asp Val Arg Lys Arg Tyr 
    450                 455                 460                 


Ser Glu Tyr Lys Lys Leu Pro Thr Lys Asp Val Leu Ala Glu Ile Tyr 
465                 470                 475                 480 


Asn Pro Thr Val Asn Lys Thr Val Ser Gln Ala Phe Lys Val Ile Asp 
                485                 490                 495     


Ala Leu Leu Val Lys Tyr Gly Lys Glu Gln Ile Arg Tyr Ile Thr Ile 
            500                 505                 510         


Glu Met Pro Arg Asp Asp Asn Glu Glu Asp Glu Lys Lys Arg Ile Lys 
        515                 520                 525             


Glu Leu His Ala Lys Asn Ser Gln Arg Lys Asn Asp Ser Gln Ser Tyr 
    530                 535                 540                 


Phe Met Gln Lys Ser Gly Trp Ser Gln Glu Lys Phe Gln Thr Thr Ile 
545                 550                 555                 560 


Gln Lys Asn Arg Arg Phe Leu Ala Lys Leu Leu Tyr Tyr Tyr Glu Gln 
                565                 570                 575     


Asp Gly Ile Cys Ala Tyr Thr Gly Leu Pro Ile Ser Pro Glu Leu Leu 
            580                 585                 590         


Val Ser Asp Ser Thr Glu Ile Asp His Ile Ile Pro Ile Ser Ile Ser 
        595                 600                 605             


Leu Asp Asp Ser Ile Asn Asn Lys Val Leu Val Leu Ser Lys Ala Asn 
    610                 615                 620                 


Gln Val Lys Gly Gln Gln Thr Pro Tyr Asp Ala Trp Met Asp Gly Ser 
625                 630                 635                 640 


Phe Lys Lys Ile Asn Gly Lys Phe Ser Asn Trp Asp Asp Tyr Gln Lys 
                645                 650                 655     


Trp Val Glu Ser Arg His Phe Ser His Lys Lys Glu Asn Asn Leu Leu 
            660                 665                 670         


Glu Thr Arg Asn Ile Phe Asp Ser Glu Gln Val Glu Lys Phe Leu Ala 
        675                 680                 685             


Arg Asn Leu Asn Asp Thr Arg Tyr Ala Ser Arg Leu Val Leu Asn Thr 
    690                 695                 700                 


Leu Gln Ser Phe Phe Thr Asn Gln Glu Thr Lys Val Arg Val Val Asn 
705                 710                 715                 720 


Gly Ser Phe Thr His Thr Leu Arg Lys Lys Trp Gly Ala Asp Leu Asp 
                725                 730                 735     


Lys Thr Arg Glu Thr His His His His Ala Val Asp Ala Thr Leu Cys 
            740                 745                 750         


Ala Val Thr Ser Phe Val Lys Val Ser Arg Tyr His Tyr Ala Val Lys 
        755                 760                 765             


Glu Glu Thr Gly Glu Lys Val Met Arg Glu Ile Asp Phe Glu Thr Gly 
    770                 775                 780                 


Glu Ile Val Asn Glu Met Ser Tyr Trp Glu Phe Lys Lys Ser Lys Lys 
785                 790                 795                 800 


Tyr Glu Arg Lys Thr Tyr Gln Val Lys Trp Pro Asn Phe Arg Glu Gln 
                805                 810                 815     


Leu Lys Pro Val Asn Leu His Pro Arg Ile Lys Phe Ser His Gln Val 
            820                 825                 830         


Asp Arg Lys Ala Asn Arg Lys Leu Ser Asp Ala Thr Ile Tyr Ser Val 
        835                 840                 845             


Arg Glu Lys Thr Glu Val Lys Thr Leu Lys Ser Gly Lys Gln Lys Ile 
    850                 855                 860                 


Thr Thr Asp Glu Tyr Thr Ile Gly Lys Ile Lys Asp Ile Tyr Thr Leu 
865                 870                 875                 880 


Asp Gly Trp Glu Ala Phe Lys Lys Lys Gln Asp Lys Leu Leu Met Lys 
                885                 890                 895     


Asp Leu Asp Glu Lys Thr Tyr Glu Arg Leu Leu Ser Ile Ala Glu Thr 
            900                 905                 910         


Thr Pro Asp Phe Gln Glu Val Glu Glu Lys Asn Gly Lys Val Lys Arg 
        915                 920                 925             


Val Lys Arg Ser Pro Phe Ala Val Tyr Cys Glu Glu Asn Asp Ile Pro 
    930                 935                 940                 


Ala Ile Gln Lys Tyr Ala Lys Lys Asn Asn Gly Pro Leu Ile Arg Ser 
945                 950                 955                 960 


Leu Lys Tyr Tyr Asp Gly Lys Leu Asn Lys His Ile Asn Ile Thr Lys 
                965                 970                 975     


Asp Ser Gln Gly Arg Pro Val Glu Lys Thr Lys Asn Gly Arg Lys Val 
            980                 985                 990         


Thr Leu Gln Ser Leu Lys Pro Tyr  Arg Tyr Asp Ile Tyr  Gln Asp Leu 
        995                 1000                 1005             


Glu Thr  Lys Ala Tyr Tyr Thr  Val Gln Leu Tyr Tyr  Ser Asp Leu 
    1010                 1015                 1020             


Arg Phe  Val Glu Gly Lys Tyr  Gly Ile Thr Glu Lys  Glu Tyr Met 
    1025                 1030                 1035             


Lys Lys  Val Ala Glu Gln Thr  Lys Gly Gln Val Val  Arg Phe Cys 
    1040                 1045                 1050             


Phe Ser  Leu Gln Lys Asn Asp  Gly Leu Glu Ile Glu  Trp Lys Asp 
    1055                 1060                 1065             


Ser Gln  Arg Tyr Asp Val Arg  Phe Tyr Asn Phe Gln  Ser Ala Asn 
    1070                 1075                 1080             


Ser Ile  Asn Phe Lys Gly Leu  Glu Gln Glu Met Met  Pro Ala Glu 
    1085                 1090                 1095             


Asn Gln  Phe Lys Gln Lys Pro  Tyr Asn Asn Gly Ala  Ile Asn Leu 
    1100                 1105                 1110             


Asn Ile  Ala Lys Tyr Gly Lys  Glu Gly Lys Lys Leu  Arg Lys Phe 
    1115                 1120                 1125             


Asn Thr  Asp Ile Leu Gly Lys  Lys His Tyr Leu Phe  Tyr Glu Lys 
    1130                 1135                 1140             


Glu Pro  Lys Asn Ile Ile Lys  
    1145                 1150 


<210>  727
<211>  1054
<212>  PRT
<213>  Staphylococcus lugdunensis M23590

<400>  727

Met Asn Gln Lys Phe Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Leu Ile Asp Tyr Glu Thr Lys Asn Ile Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Pro Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ser Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu 
    50                  55                  60                  


Glu Arg Val Lys Lys Leu Leu Glu Asp Tyr Asn Leu Leu Asp Gln Ser 
65                  70                  75                  80  


Gln Ile Pro Gln Ser Thr Asn Pro Tyr Ala Ile Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Glu Ala Leu Ser Lys Asp Glu Leu Val Ile Ala Leu Leu His Ile 
            100                 105                 110         


Ala Lys Arg Arg Gly Ile His Lys Ile Asp Val Ile Asp Ser Asn Asp 
        115                 120                 125             


Asp Val Gly Asn Glu Leu Ser Thr Lys Glu Gln Leu Asn Lys Asn Ser 
    130                 135                 140                 


Lys Leu Leu Lys Asp Lys Phe Val Cys Gln Ile Gln Leu Glu Arg Met 
145                 150                 155                 160 


Asn Glu Gly Gln Val Arg Gly Glu Lys Asn Arg Phe Lys Thr Ala Asp 
                165                 170                 175     


Ile Ile Lys Glu Ile Ile Gln Leu Leu Asn Val Gln Lys Asn Phe His 
            180                 185                 190         


Gln Leu Asp Glu Asn Phe Ile Asn Lys Tyr Ile Glu Leu Val Glu Met 
        195                 200                 205             


Arg Arg Glu Tyr Phe Glu Gly Pro Gly Lys Gly Ser Pro Tyr Gly Trp 
    210                 215                 220                 


Glu Gly Asp Pro Lys Ala Trp Tyr Glu Thr Leu Met Gly His Cys Thr 
225                 230                 235                 240 


Tyr Phe Pro Asp Glu Leu Arg Ser Val Lys Tyr Ala Tyr Ser Ala Asp 
                245                 250                 255     


Leu Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Gln Arg Asp 
            260                 265                 270         


Gly Leu Ser Lys Leu Glu Tyr His Glu Lys Tyr His Ile Ile Glu Asn 
        275                 280                 285             


Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Asn Glu 
    290                 295                 300                 


Ile Asn Val Asn Pro Glu Asp Ile Lys Gly Tyr Arg Ile Thr Lys Ser 
305                 310                 315                 320 


Gly Lys Pro Gln Phe Thr Glu Phe Lys Leu Tyr His Asp Leu Lys Ser 
                325                 330                 335     


Val Leu Phe Asp Gln Ser Ile Leu Glu Asn Glu Asp Val Leu Asp Gln 
            340                 345                 350         


Ile Ala Glu Ile Leu Thr Ile Tyr Gln Asp Lys Asp Ser Ile Lys Ser 
        355                 360                 365             


Lys Leu Thr Glu Leu Asp Ile Leu Leu Asn Glu Glu Asp Lys Glu Asn 
    370                 375                 380                 


Ile Ala Gln Leu Thr Gly Tyr Thr Gly Thr His Arg Leu Ser Leu Lys 
385                 390                 395                 400 


Cys Ile Arg Leu Val Leu Glu Glu Gln Trp Tyr Ser Ser Arg Asn Gln 
                405                 410                 415     


Met Glu Ile Phe Thr His Leu Asn Ile Lys Pro Lys Lys Ile Asn Leu 
            420                 425                 430         


Thr Ala Ala Asn Lys Ile Pro Lys Ala Met Ile Asp Glu Phe Ile Leu 
        435                 440                 445             


Ser Pro Val Val Lys Arg Thr Phe Gly Gln Ala Ile Asn Leu Ile Asn 
    450                 455                 460                 


Lys Ile Ile Glu Lys Tyr Gly Val Pro Glu Asp Ile Ile Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Asn Asn Ser Lys Asp Lys Gln Lys Phe Ile Asn Glu Met 
                485                 490                 495     


Gln Lys Lys Asn Glu Asn Thr Arg Lys Arg Ile Asn Glu Ile Ile Gly 
            500                 505                 510         


Lys Tyr Gly Asn Gln Asn Ala Lys Arg Leu Val Glu Lys Ile Arg Leu 
        515                 520                 525             


His Asp Glu Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ser Ile Pro 
    530                 535                 540                 


Leu Glu Asp Leu Leu Asn Asn Pro Asn His Tyr Glu Val Asp His Ile 
545                 550                 555                 560 


Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Tyr His Asn Lys Val Leu 
                565                 570                 575     


Val Lys Gln Ser Glu Asn Ser Lys Lys Ser Asn Leu Thr Pro Tyr Gln 
            580                 585                 590         


Tyr Phe Asn Ser Gly Lys Ser Lys Leu Ser Tyr Asn Gln Phe Lys Gln 
        595                 600                 605             


His Ile Leu Asn Leu Ser Lys Ser Gln Asp Arg Ile Ser Lys Lys Lys 
    610                 615                 620                 


Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe Glu Val Gln 
625                 630                 635                 640 


Lys Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg 
                645                 650                 655     


Glu Leu Thr Asn Tyr Leu Lys Ala Tyr Phe Ser Ala Asn Asn Met Asn 
            660                 665                 670         


Val Lys Val Lys Thr Ile Asn Gly Ser Phe Thr Asp Tyr Leu Arg Lys 
        675                 680                 685             


Val Trp Lys Phe Lys Lys Glu Arg Asn His Gly Tyr Lys His His Ala 
    690                 695                 700                 


Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe Lys Glu Asn 
705                 710                 715                 720 


Lys Lys Leu Lys Ala Val Asn Ser Val Leu Glu Lys Pro Glu Ile Glu 
                725                 730                 735     


Ser Lys Gln Leu Asp Ile Gln Val Asp Ser Glu Asp Asn Tyr Ser Glu 
            740                 745                 750         


Met Phe Ile Ile Pro Lys Gln Val Gln Asp Ile Lys Asp Phe Arg Asn 
        755                 760                 765             


Phe Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Gln Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Lys Asp Asn Ser Thr Tyr Ile 
785                 790                 795                 800 


Val Gln Thr Ile Lys Asp Ile Tyr Ala Lys Asp Asn Thr Thr Leu Lys 
                805                 810                 815     


Lys Gln Phe Asp Lys Ser Pro Glu Lys Phe Leu Met Tyr Gln His Asp 
            820                 825                 830         


Pro Arg Thr Phe Glu Lys Leu Glu Val Ile Met Lys Gln Tyr Ala Asn 
        835                 840                 845             


Glu Lys Asn Pro Leu Ala Lys Tyr His Glu Glu Thr Gly Glu Tyr Leu 
    850                 855                 860                 


Thr Lys Tyr Ser Lys Lys Asn Asn Gly Pro Ile Val Lys Ser Leu Lys 
865                 870                 875                 880 


Tyr Ile Gly Asn Lys Leu Gly Ser His Leu Asp Val Thr His Gln Phe 
                885                 890                 895     


Lys Ser Ser Thr Lys Lys Leu Val Lys Leu Ser Ile Lys Pro Tyr Arg 
            900                 905                 910         


Phe Asp Val Tyr Leu Thr Asp Lys Gly Tyr Lys Phe Ile Thr Ile Ser 
        915                 920                 925             


Tyr Leu Asp Val Leu Lys Lys Asp Asn Tyr Tyr Tyr Ile Pro Glu Gln 
    930                 935                 940                 


Lys Tyr Asp Lys Leu Lys Leu Gly Lys Ala Ile Asp Lys Asn Ala Lys 
945                 950                 955                 960 


Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Leu Asp Gly Glu 
                965                 970                 975     


Ile Tyr Lys Ile Ile Gly Val Asn Ser Asp Thr Arg Asn Met Ile Glu 
            980                 985                 990         


Leu Asp Leu Pro Asp Ile Arg Tyr  Lys Glu Tyr Cys Glu  Leu Asn Asn 
        995                 1000                 1005             


Ile Lys  Gly Glu Pro Arg Ile  Lys Lys Thr Ile Gly  Lys Lys Val 
    1010                 1015                 1020             


Asn Ser  Ile Glu Lys Leu Thr  Thr Asp Val Leu Gly  Asn Val Phe 
    1025                 1030                 1035             


Thr Asn  Thr Gln Tyr Thr Lys  Pro Gln Leu Leu Phe  Lys Arg Gly 
    1040                 1045                 1050             


Asn 
    


<210>  728
<211>  1096
<212>  PRT
<213>  Eubacterium dolichum DSM 3991

<400>  728

Met Met Glu Val Phe Met Gly Arg Leu Val Leu Gly Leu Asp Ile Gly 
1               5                   10                  15      


Ile Thr Ser Val Gly Phe Gly Ile Ile Asp Leu Asp Glu Ser Glu Ile 
            20                  25                  30          


Val Asp Tyr Gly Val Arg Leu Phe Lys Glu Gly Thr Ala Ala Glu Asn 
        35                  40                  45              


Glu Thr Arg Arg Thr Lys Arg Gly Gly Arg Arg Leu Lys Arg Arg Arg 
    50                  55                  60                  


Val Thr Arg Arg Glu Asp Met Leu His Leu Leu Lys Gln Ala Gly Ile 
65                  70                  75                  80  


Ile Ser Thr Ser Phe His Pro Leu Asn Asn Pro Tyr Asp Val Arg Val 
                85                  90                  95      


Lys Gly Leu Asn Glu Arg Leu Asn Gly Glu Glu Leu Ala Thr Ala Leu 
            100                 105                 110         


Leu His Leu Cys Lys His Arg Gly Ser Ser Val Glu Thr Ile Glu Asp 
        115                 120                 125             


Asp Glu Ala Lys Ala Lys Glu Ala Gly Glu Thr Lys Lys Val Leu Ser 
    130                 135                 140                 


Met Asn Asp Gln Leu Leu Lys Ser Gly Lys Tyr Val Cys Glu Ile Gln 
145                 150                 155                 160 


Lys Glu Arg Leu Arg Thr Asn Gly His Ile Arg Gly His Glu Asn Asn 
                165                 170                 175     


Phe Lys Thr Arg Ala Tyr Val Asp Glu Ala Phe Gln Ile Leu Ser His 
            180                 185                 190         


Gln Asp Leu Ser Asn Glu Leu Lys Ser Ala Ile Ile Thr Ile Ile Ser 
        195                 200                 205             


Arg Lys Arg Met Tyr Tyr Asp Gly Pro Gly Gly Pro Leu Ser Pro Thr 
    210                 215                 220                 


Pro Tyr Gly Arg Tyr Thr Tyr Phe Gly Gln Lys Glu Pro Ile Asp Leu 
225                 230                 235                 240 


Ile Glu Lys Met Arg Gly Lys Cys Ser Leu Phe Pro Asn Glu Pro Arg 
                245                 250                 255     


Ala Pro Lys Leu Ala Tyr Ser Ala Glu Leu Phe Asn Leu Leu Asn Asp 
            260                 265                 270         


Leu Asn Asn Leu Ser Ile Glu Gly Glu Lys Leu Thr Ser Glu Gln Lys 
        275                 280                 285             


Ala Met Ile Leu Lys Ile Val His Glu Lys Gly Lys Ile Thr Pro Lys 
    290                 295                 300                 


Gln Leu Ala Lys Glu Val Gly Val Ser Leu Glu Gln Ile Arg Gly Phe 
305                 310                 315                 320 


Arg Ile Asp Thr Lys Gly Ser Pro Leu Leu Ser Glu Leu Thr Gly Tyr 
                325                 330                 335     


Lys Met Ile Arg Glu Val Leu Glu Lys Ser Asn Asp Glu His Leu Glu 
            340                 345                 350         


Asp His Val Phe Tyr Asp Glu Ile Ala Glu Ile Leu Thr Lys Thr Lys 
        355                 360                 365             


Asp Ile Glu Gly Arg Lys Lys Gln Ile Ser Glu Leu Ser Ser Asp Leu 
    370                 375                 380                 


Asn Glu Glu Ser Val His Gln Leu Ala Gly Leu Thr Lys Phe Thr Ala 
385                 390                 395                 400 


Tyr His Ser Leu Ser Phe Lys Ala Leu Arg Leu Ile Asn Glu Glu Met 
                405                 410                 415     


Leu Lys Thr Glu Leu Asn Gln Met Gln Ser Ile Thr Leu Phe Gly Leu 
            420                 425                 430         


Lys Gln Asn Asn Glu Leu Ser Val Lys Gly Met Lys Asn Ile Gln Ala 
        435                 440                 445             


Asp Asp Thr Ala Ile Leu Ser Pro Val Ala Lys Arg Ala Gln Arg Glu 
    450                 455                 460                 


Thr Phe Lys Val Val Asn Arg Leu Arg Glu Ile Tyr Gly Glu Phe Asp 
465                 470                 475                 480 


Ser Ile Val Val Glu Met Ala Arg Glu Lys Asn Ser Glu Glu Gln Arg 
                485                 490                 495     


Lys Ala Ile Arg Glu Arg Gln Lys Phe Phe Glu Met Arg Asn Lys Gln 
            500                 505                 510         


Val Ala Asp Ile Ile Gly Asp Asp Arg Lys Ile Asn Ala Lys Leu Arg 
        515                 520                 525             


Glu Lys Leu Val Leu Tyr Gln Glu Gln Asp Gly Lys Thr Ala Tyr Ser 
    530                 535                 540                 


Leu Glu Pro Ile Asp Leu Lys Leu Leu Ile Asp Asp Pro Asn Ala Tyr 
545                 550                 555                 560 


Glu Val Asp His Ile Ile Pro Ile Ser Ile Ser Leu Asp Asp Ser Ile 
                565                 570                 575     


Thr Asn Lys Val Leu Val Thr His Arg Glu Asn Gln Glu Lys Gly Asn 
            580                 585                 590         


Leu Thr Pro Ile Ser Ala Phe Val Lys Gly Arg Phe Thr Lys Gly Ser 
        595                 600                 605             


Leu Ala Gln Tyr Lys Ala Tyr Cys Leu Lys Leu Lys Glu Lys Asn Ile 
    610                 615                 620                 


Lys Thr Asn Lys Gly Tyr Arg Lys Lys Val Glu Gln Tyr Leu Leu Asn 
625                 630                 635                 640 


Glu Asn Asp Ile Tyr Lys Tyr Asp Ile Gln Lys Glu Phe Ile Asn Arg 
                645                 650                 655     


Asn Leu Val Asp Thr Ser Tyr Ala Ser Arg Val Val Leu Asn Thr Leu 
            660                 665                 670         


Thr Thr Tyr Phe Lys Gln Asn Glu Ile Pro Thr Lys Val Phe Thr Val 
        675                 680                 685             


Lys Gly Ser Leu Thr Asn Ala Phe Arg Arg Lys Ile Asn Leu Lys Lys 
    690                 695                 700                 


Asp Arg Asp Glu Asp Tyr Gly His His Ala Ile Asp Ala Leu Ile Ile 
705                 710                 715                 720 


Ala Ser Met Pro Lys Met Arg Leu Leu Ser Thr Ile Phe Ser Arg Tyr 
                725                 730                 735     


Lys Ile Glu Asp Ile Tyr Asp Glu Ser Thr Gly Glu Val Phe Ser Ser 
            740                 745                 750         


Gly Asp Asp Ser Met Tyr Tyr Asp Asp Arg Tyr Phe Ala Phe Ile Ala 
        755                 760                 765             


Ser Leu Lys Ala Ile Lys Val Arg Lys Phe Ser His Lys Ile Asp Thr 
    770                 775                 780                 


Lys Pro Asn Arg Ser Val Ala Asp Glu Thr Ile Tyr Ser Thr Arg Val 
785                 790                 795                 800 


Ile Asp Gly Lys Glu Lys Val Val Lys Lys Tyr Lys Asp Ile Tyr Asp 
                805                 810                 815     


Pro Lys Phe Thr Ala Leu Ala Glu Asp Ile Leu Asn Asn Ala Tyr Gln 
            820                 825                 830         


Glu Lys Tyr Leu Met Ala Leu His Asp Pro Gln Thr Phe Asp Gln Ile 
        835                 840                 845             


Val Lys Val Val Asn Tyr Tyr Phe Glu Glu Met Ser Lys Ser Glu Lys 
    850                 855                 860                 


Tyr Phe Thr Lys Asp Lys Lys Gly Arg Ile Lys Ile Ser Gly Met Asn 
865                 870                 875                 880 


Pro Leu Ser Leu Tyr Arg Asp Glu His Gly Met Leu Lys Lys Tyr Ser 
                885                 890                 895     


Lys Lys Gly Asp Gly Pro Ala Ile Thr Gln Met Lys Tyr Phe Asp Gly 
            900                 905                 910         


Val Leu Gly Asn His Ile Asp Ile Ser Ala His Tyr Gln Val Arg Asp 
        915                 920                 925             


Lys Lys Val Val Leu Gln Gln Ile Ser Pro Tyr Arg Thr Asp Phe Tyr 
    930                 935                 940                 


Tyr Ser Lys Glu Asn Gly Tyr Lys Phe Val Thr Ile Arg Tyr Lys Asp 
945                 950                 955                 960 


Val Arg Trp Ser Glu Lys Lys Lys Lys Tyr Val Ile Asp Gln Gln Asp 
                965                 970                 975     


Tyr Ala Met Lys Lys Ala Glu Lys Lys Ile Asp Asp Thr Tyr Glu Phe 
            980                 985                 990         


Gln Phe Ser Met His Arg Asp Glu  Leu Ile Gly Ile Thr  Lys Ala Glu 
        995                 1000                 1005             


Gly Glu  Ala Leu Ile Tyr Pro  Asp Glu Thr Trp His  Asn Phe Asn 
    1010                 1015                 1020             


Phe Phe  Phe His Ala Gly Glu  Thr Pro Glu Ile Leu  Lys Phe Thr 
    1025                 1030                 1035             


Ala Thr  Asn Asn Asp Lys Ser  Asn Lys Ile Glu Val  Lys Pro Ile 
    1040                 1045                 1050             


His Cys  Tyr Cys Lys Met Arg  Leu Met Pro Thr Ile  Ser Lys Lys 
    1055                 1060                 1065             


Ile Val  Arg Ile Asp Lys Tyr  Ala Thr Asp Val Val  Gly Asn Leu 
    1070                 1075                 1080             


Tyr Lys  Val Lys Lys Asn Thr  Leu Lys Phe Glu Phe  Asp 
    1085                 1090                 1095     


<210>  729
<211>  1119
<212>  PRT
<213>  Lactobacillus coryniformis subsp. torquens KCTC 3535

<400>  729

Met Gly Tyr Arg Ile Gly Leu Asp Val Gly Ile Thr Ser Thr Gly Tyr 
1               5                   10                  15      


Ala Val Leu Lys Thr Asp Lys Asn Gly Leu Pro Tyr Lys Ile Leu Thr 
            20                  25                  30          


Leu Asp Ser Val Ile Tyr Pro Arg Ala Glu Asn Pro Gln Thr Gly Ala 
        35                  40                  45              


Ser Leu Ala Glu Pro Arg Arg Ile Lys Arg Gly Leu Arg Arg Arg Thr 
    50                  55                  60                  


Arg Arg Thr Lys Phe Arg Lys Gln Arg Thr Gln Gln Leu Phe Ile His 
65                  70                  75                  80  


Ser Gly Leu Leu Ser Lys Pro Glu Ile Glu Gln Ile Leu Ala Thr Pro 
                85                  90                  95      


Gln Ala Lys Tyr Ser Val Tyr Glu Leu Arg Val Ala Gly Leu Asp Arg 
            100                 105                 110         


Arg Leu Thr Asn Ser Glu Leu Phe Arg Val Leu Tyr Phe Phe Ile Gly 
        115                 120                 125             


His Arg Gly Phe Lys Ser Asn Arg Lys Ala Glu Leu Asn Pro Glu Asn 
    130                 135                 140                 


Glu Ala Asp Lys Lys Gln Met Gly Gln Leu Leu Asn Ser Ile Glu Glu 
145                 150                 155                 160 


Ile Arg Lys Ala Ile Ala Glu Lys Gly Tyr Arg Thr Val Gly Glu Leu 
                165                 170                 175     


Tyr Leu Lys Asp Pro Lys Tyr Asn Asp His Lys Arg Asn Lys Gly Tyr 
            180                 185                 190         


Ile Asp Gly Tyr Leu Ser Thr Pro Asn Arg Gln Met Leu Val Asp Glu 
        195                 200                 205             


Ile Lys Gln Ile Leu Asp Lys Gln Arg Glu Leu Gly Asn Glu Lys Leu 
    210                 215                 220                 


Thr Asp Glu Phe Tyr Ala Thr Tyr Leu Leu Gly Asp Glu Asn Arg Ala 
225                 230                 235                 240 


Gly Ile Phe Gln Ala Gln Arg Asp Phe Asp Glu Gly Pro Gly Ala Gly 
                245                 250                 255     


Pro Tyr Ala Gly Asp Gln Ile Lys Lys Met Val Gly Lys Asp Ile Phe 
            260                 265                 270         


Glu Pro Thr Glu Asp Arg Ala Ala Lys Ala Thr Tyr Thr Phe Gln Tyr 
        275                 280                 285             


Phe Asn Leu Leu Gln Lys Met Thr Ser Leu Asn Tyr Gln Asn Thr Thr 
    290                 295                 300                 


Gly Asp Thr Trp His Thr Leu Asn Gly Leu Asp Arg Gln Ala Ile Ile 
305                 310                 315                 320 


Asp Ala Val Phe Ala Lys Ala Glu Lys Pro Thr Lys Thr Tyr Lys Pro 
                325                 330                 335     


Thr Asp Phe Gly Glu Leu Arg Lys Leu Leu Lys Leu Pro Asp Asp Ala 
            340                 345                 350         


Arg Phe Asn Leu Val Asn Tyr Gly Ser Leu Gln Thr Gln Lys Glu Ile 
        355                 360                 365             


Glu Thr Val Glu Lys Lys Thr Arg Phe Val Asp Phe Lys Ala Tyr His 
    370                 375                 380                 


Asp Leu Val Lys Val Leu Pro Glu Glu Met Trp Gln Ser Arg Gln Leu 
385                 390                 395                 400 


Leu Asp His Ile Gly Thr Ala Leu Thr Leu Tyr Ser Ser Asp Lys Arg 
                405                 410                 415     


Arg Arg Arg Tyr Phe Ala Glu Glu Leu Asn Leu Pro Ala Glu Leu Ile 
            420                 425                 430         


Glu Lys Leu Leu Pro Leu Asn Phe Ser Lys Phe Gly His Leu Ser Ile 
        435                 440                 445             


Lys Ser Met Gln Asn Ile Ile Pro Tyr Leu Glu Met Gly Gln Val Tyr 
    450                 455                 460                 


Ser Glu Ala Thr Thr Asn Thr Gly Tyr Asp Phe Arg Lys Lys Gln Ile 
465                 470                 475                 480 


Ser Lys Asp Thr Ile Arg Glu Glu Ile Thr Asn Pro Val Val Arg Arg 
                485                 490                 495     


Ala Val Thr Lys Thr Ile Lys Ile Val Glu Gln Ile Ile Arg Arg Tyr 
            500                 505                 510         


Gly Lys Pro Asp Gly Ile Asn Ile Glu Leu Ala Arg Glu Leu Gly Arg 
        515                 520                 525             


Asn Phe Lys Glu Arg Gly Asp Ile Gln Lys Arg Gln Asp Lys Asn Arg 
    530                 535                 540                 


Gln Thr Asn Asp Lys Ile Ala Ala Glu Leu Thr Glu Leu Gly Ile Pro 
545                 550                 555                 560 


Val Asn Gly Gln Asn Ile Ile Arg Tyr Lys Leu His Lys Glu Gln Asn 
                565                 570                 575     


Gly Val Asp Pro Tyr Thr Gly Asp Gln Ile Pro Phe Glu Arg Ala Phe 
            580                 585                 590         


Ser Glu Gly Tyr Glu Val Asp His Ile Ile Pro Tyr Ser Ile Ser Trp 
        595                 600                 605             


Asp Asp Ser Tyr Thr Asn Lys Val Leu Thr Ser Ala Lys Cys Asn Arg 
    610                 615                 620                 


Glu Lys Gly Asn Arg Ile Pro Met Val Tyr Leu Ala Asn Asn Glu Gln 
625                 630                 635                 640 


Arg Leu Asn Ala Leu Thr Asn Ile Ala Asp Asn Ile Ile Arg Asn Ser 
                645                 650                 655     


Arg Lys Arg Gln Lys Leu Leu Lys Gln Lys Leu Ser Asp Glu Glu Leu 
            660                 665                 670         


Lys Asp Trp Lys Gln Arg Asn Ile Asn Asp Thr Arg Phe Ile Thr Arg 
        675                 680                 685             


Val Leu Tyr Asn Tyr Phe Arg Gln Ala Ile Glu Phe Asn Pro Glu Leu 
    690                 695                 700                 


Glu Lys Lys Gln Arg Val Leu Pro Leu Asn Gly Glu Val Thr Ser Lys 
705                 710                 715                 720 


Ile Arg Ser Arg Trp Gly Phe Leu Lys Val Arg Glu Asp Gly Asp Leu 
                725                 730                 735     


His His Ala Ile Asp Ala Thr Val Ile Ala Ala Ile Thr Pro Lys Phe 
            740                 745                 750         


Ile Gln Gln Val Thr Lys Tyr Ser Gln His Gln Glu Val Lys Asn Asn 
        755                 760                 765             


Gln Ala Leu Trp His Asp Ala Glu Ile Lys Asp Ala Glu Tyr Ala Ala 
    770                 775                 780                 


Glu Ala Gln Arg Met Asp Ala Asp Leu Phe Asn Lys Ile Phe Asn Gly 
785                 790                 795                 800 


Phe Pro Leu Pro Trp Pro Glu Phe Leu Asp Glu Leu Leu Ala Arg Ile 
                805                 810                 815     


Ser Asp Asn Pro Val Glu Met Met Lys Ser Arg Ser Trp Asn Thr Tyr 
            820                 825                 830         


Thr Pro Ile Glu Ile Ala Lys Leu Lys Pro Val Phe Val Val Arg Leu 
        835                 840                 845             


Ala Asn His Lys Ile Ser Gly Pro Ala His Leu Asp Thr Ile Arg Ser 
    850                 855                 860                 


Ala Lys Leu Phe Asp Glu Lys Gly Ile Val Leu Ser Arg Val Ser Ile 
865                 870                 875                 880 


Thr Lys Leu Lys Ile Asn Lys Lys Gly Gln Val Ala Thr Gly Asp Gly 
                885                 890                 895     


Ile Tyr Asp Pro Glu Asn Ser Asn Asn Gly Asp Lys Val Val Tyr Ser 
            900                 905                 910         


Ala Ile Arg Gln Ala Leu Glu Ala His Asn Gly Ser Gly Glu Leu Ala 
        915                 920                 925             


Phe Pro Asp Gly Tyr Leu Glu Tyr Val Asp His Gly Thr Lys Lys Leu 
    930                 935                 940                 


Val Arg Lys Val Arg Val Ala Lys Lys Val Ser Leu Pro Val Arg Leu 
945                 950                 955                 960 


Lys Asn Lys Ala Ala Ala Asp Asn Gly Ser Met Val Arg Ile Asp Val 
                965                 970                 975     


Phe Asn Thr Gly Lys Lys Phe Val Phe Val Pro Ile Tyr Ile Lys Asp 
            980                 985                 990         


Thr Val Glu Gln Val Leu Pro Asn  Lys Ala Ile Ala Arg  Gly Lys Ser 
        995                 1000                 1005             


Leu Trp  Tyr Gln Ile Thr Glu  Ser Asp Gln Phe Cys  Phe Ser Leu 
    1010                 1015                 1020             


Tyr Pro  Gly Asp Met Val His  Ile Glu Ser Lys Thr  Gly Ile Lys 
    1025                 1030                 1035             


Pro Lys  Tyr Ser Asn Lys Glu  Asn Asn Thr Ser Val  Val Pro Ile 
    1040                 1045                 1050             


Lys Asn  Phe Tyr Gly Tyr Phe  Asp Gly Ala Asp Ile  Ala Thr Ala 
    1055                 1060                 1065             


Ser Ile  Leu Val Arg Ala His  Asp Ser Ser Tyr Thr  Ala Arg Ser 
    1070                 1075                 1080             


Ile Gly  Ile Ala Gly Leu Leu  Lys Phe Glu Lys Tyr  Gln Val Asp 
    1085                 1090                 1095             


Tyr Phe  Gly Arg Tyr His Lys  Val His Glu Lys Lys  Arg Gln Leu 
    1100                 1105                 1110             


Phe Val  Lys Arg Asp Glu 
    1115                 


<210>  730
<211>  1092
<212>  PRT
<213>  Ilyobacter polytropus DSM 2926

<400>  730

Met Lys Tyr Ser Ile Gly Leu Asp Ile Gly Ile Ala Ser Val Gly Trp 
1               5                   10                  15      


Ser Val Ile Asn Lys Asp Lys Glu Arg Ile Glu Asp Met Gly Val Arg 
            20                  25                  30          


Ile Phe Gln Lys Ala Glu Asn Pro Lys Asp Gly Ser Ser Leu Ala Ser 
        35                  40                  45              


Ser Arg Arg Glu Lys Arg Gly Ser Arg Arg Arg Asn Arg Arg Lys Lys 
    50                  55                  60                  


His Arg Leu Asp Arg Ile Lys Asn Ile Leu Cys Glu Ser Gly Leu Val 
65                  70                  75                  80  


Lys Lys Asn Glu Ile Glu Lys Ile Tyr Lys Asn Ala Tyr Leu Lys Ser 
                85                  90                  95      


Pro Trp Glu Leu Arg Ala Lys Ser Leu Glu Ala Lys Ile Ser Asn Lys 
            100                 105                 110         


Glu Ile Ala Gln Ile Leu Leu His Ile Ala Lys Arg Arg Gly Phe Lys 
        115                 120                 125             


Ser Phe Arg Lys Thr Asp Arg Asn Ala Asp Asp Thr Gly Lys Leu Leu 
    130                 135                 140                 


Ser Gly Ile Gln Glu Asn Lys Lys Ile Met Glu Glu Lys Gly Tyr Leu 
145                 150                 155                 160 


Thr Ile Gly Asp Met Val Ala Lys Asp Pro Lys Phe Asn Thr His Val 
                165                 170                 175     


Arg Asn Lys Ala Gly Ser Tyr Leu Phe Ser Phe Ser Arg Lys Leu Leu 
            180                 185                 190         


Glu Asp Glu Val Arg Lys Ile Gln Ala Lys Gln Lys Glu Leu Gly Asn 
        195                 200                 205             


Thr His Phe Thr Asp Asp Val Leu Glu Lys Tyr Ile Glu Val Phe Asn 
    210                 215                 220                 


Ser Gln Arg Asn Phe Asp Glu Gly Pro Ser Lys Pro Ser Pro Tyr Tyr 
225                 230                 235                 240 


Ser Glu Ile Gly Gln Ile Ala Lys Met Ile Gly Asn Cys Thr Phe Glu 
                245                 250                 255     


Ser Ser Glu Lys Arg Thr Ala Lys Asn Thr Trp Ser Gly Glu Arg Phe 
            260                 265                 270         


Val Phe Leu Gln Lys Leu Asn Asn Phe Arg Ile Val Gly Leu Ser Gly 
        275                 280                 285             


Lys Arg Pro Leu Thr Glu Glu Glu Arg Asp Ile Val Glu Lys Glu Val 
    290                 295                 300                 


Tyr Leu Lys Lys Glu Val Arg Tyr Glu Lys Leu Arg Lys Ile Leu Tyr 
305                 310                 315                 320 


Leu Lys Glu Glu Glu Arg Phe Gly Asp Leu Asn Tyr Ser Lys Asp Glu 
                325                 330                 335     


Lys Gln Asp Lys Lys Thr Glu Lys Thr Lys Phe Ile Ser Leu Ile Gly 
            340                 345                 350         


Asn Tyr Thr Ile Lys Lys Leu Asn Leu Ser Glu Lys Leu Lys Ser Glu 
        355                 360                 365             


Ile Glu Glu Asp Lys Ser Lys Leu Asp Lys Ile Ile Glu Ile Leu Thr 
    370                 375                 380                 


Phe Asn Lys Ser Asp Lys Thr Ile Glu Ser Asn Leu Lys Lys Leu Glu 
385                 390                 395                 400 


Leu Ser Arg Glu Asp Ile Glu Ile Leu Leu Ser Glu Glu Phe Ser Gly 
                405                 410                 415     


Thr Leu Asn Leu Ser Leu Lys Ala Ile Lys Lys Ile Leu Pro Tyr Leu 
            420                 425                 430         


Glu Lys Gly Leu Ser Tyr Asn Glu Ala Cys Glu Lys Ala Asp Tyr Asp 
        435                 440                 445             


Tyr Lys Asn Asn Gly Ile Lys Phe Lys Arg Gly Glu Leu Leu Pro Val 
    450                 455                 460                 


Val Asp Lys Asp Leu Ile Ala Asn Pro Val Val Leu Arg Ala Ile Ser 
465                 470                 475                 480 


Gln Thr Arg Lys Val Val Asn Ala Ile Ile Arg Lys Tyr Gly Thr Pro 
                485                 490                 495     


His Thr Ile His Val Glu Val Ala Arg Asp Leu Ala Lys Ser Tyr Asp 
            500                 505                 510         


Asp Arg Gln Thr Ile Ile Lys Glu Asn Lys Lys Arg Glu Leu Glu Asn 
        515                 520                 525             


Glu Lys Thr Lys Lys Phe Ile Ser Glu Glu Phe Gly Ile Lys Asn Val 
    530                 535                 540                 


Lys Gly Lys Leu Leu Leu Lys Tyr Arg Leu Tyr Gln Glu Gln Glu Gly 
545                 550                 555                 560 


Arg Cys Ala Tyr Ser Arg Lys Glu Leu Ser Leu Ser Glu Val Ile Leu 
                565                 570                 575     


Asp Glu Ser Met Thr Asp Ile Asp His Ile Ile Pro Tyr Ser Arg Ser 
            580                 585                 590         


Met Asp Asp Ser Tyr Ser Asn Lys Val Leu Val Leu Ser Gly Glu Asn 
        595                 600                 605             


Arg Lys Lys Ser Asn Leu Leu Pro Lys Glu Tyr Phe Asp Arg Gln Gly 
    610                 615                 620                 


Arg Asp Trp Asp Thr Phe Val Leu Asn Val Lys Ala Met Lys Ile His 
625                 630                 635                 640 


Pro Arg Lys Lys Ser Asn Leu Leu Lys Glu Lys Phe Thr Arg Glu Asp 
                645                 650                 655     


Asn Lys Asp Trp Lys Ser Arg Ala Leu Asn Asp Thr Arg Tyr Ile Ser 
            660                 665                 670         


Arg Phe Val Ala Asn Tyr Leu Glu Asn Ala Leu Glu Tyr Arg Asp Asp 
        675                 680                 685             


Ser Pro Lys Lys Arg Val Phe Met Ile Pro Gly Gln Leu Thr Ala Gln 
    690                 695                 700                 


Leu Arg Ala Arg Trp Arg Leu Asn Lys Val Arg Glu Asn Gly Asp Leu 
705                 710                 715                 720 


His His Ala Leu Asp Ala Ala Val Val Ala Val Thr Asp Gln Lys Ala 
                725                 730                 735     


Ile Asn Asn Ile Ser Asn Ile Ser Arg Tyr Lys Glu Leu Lys Asn Cys 
            740                 745                 750         


Lys Asp Val Ile Pro Ser Ile Glu Tyr His Ala Asp Glu Glu Thr Gly 
        755                 760                 765             


Glu Val Tyr Phe Glu Glu Val Lys Asp Thr Arg Phe Pro Met Pro Trp 
    770                 775                 780                 


Ser Gly Phe Asp Leu Glu Leu Gln Lys Arg Leu Glu Ser Glu Asn Pro 
785                 790                 795                 800 


Arg Glu Glu Phe Tyr Asn Leu Leu Ser Asp Lys Arg Tyr Leu Gly Trp 
                805                 810                 815     


Phe Asn Tyr Glu Glu Gly Phe Ile Glu Lys Leu Arg Pro Val Phe Val 
            820                 825                 830         


Ser Arg Met Pro Asn Arg Gly Val Lys Gly Gln Ala His Gln Glu Thr 
        835                 840                 845             


Ile Arg Ser Ser Lys Lys Ile Ser Asn Gln Ile Ala Val Ser Lys Lys 
    850                 855                 860                 


Pro Leu Asn Ser Ile Lys Leu Lys Asp Leu Glu Lys Met Gln Gly Arg 
865                 870                 875                 880 


Asp Thr Asp Arg Lys Leu Tyr Glu Ala Leu Lys Asn Arg Leu Glu Glu 
                885                 890                 895     


Tyr Asp Asp Lys Pro Glu Lys Ala Phe Ala Glu Pro Phe Tyr Lys Pro 
            900                 905                 910         


Thr Asn Ser Gly Lys Arg Gly Pro Leu Val Arg Gly Ile Lys Val Glu 
        915                 920                 925             


Glu Lys Gln Asn Val Gly Val Tyr Val Asn Gly Gly Gln Ala Ser Asn 
    930                 935                 940                 


Gly Ser Met Val Arg Ile Asp Val Phe Arg Lys Asn Gly Lys Phe Tyr 
945                 950                 955                 960 


Thr Val Pro Ile Tyr Val His Gln Thr Leu Leu Lys Glu Leu Pro Asn 
                965                 970                 975     


Arg Ala Ile Asn Gly Lys Pro Tyr Lys Asp Trp Asp Leu Ile Asp Gly 
            980                 985                 990         


Ser Phe Glu Phe Leu Tyr Ser Phe  Tyr Pro Asn Asp Leu  Ile Glu Ile 
        995                 1000                 1005             


Glu Phe  Gly Lys Ser Lys Ser  Ile Lys Asn Asp Asn  Lys Leu Thr 
    1010                 1015                 1020             


Lys Thr  Glu Ile Pro Glu Val  Asn Leu Ser Glu Val  Leu Gly Tyr 
    1025                 1030                 1035             


Tyr Arg  Gly Met Asp Thr Ser  Thr Gly Ala Ala Thr  Ile Asp Thr 
    1040                 1045                 1050             


Gln Asp  Gly Lys Ile Gln Met  Arg Ile Gly Ile Lys  Thr Val Lys 
    1055                 1060                 1065             


Asn Ile  Lys Lys Tyr Gln Val  Asp Val Leu Gly Asn  Val Tyr Lys 
    1070                 1075                 1080             


Val Lys  Arg Glu Lys Arg Gln  Thr Phe 
    1085                 1090         


<210>  731
<211>  1156
<212>  PRT
<213>  Ruminococcus albus 8

<400>  731

Met Gly Asn Tyr Tyr Leu Gly Leu Asp Val Gly Ile Gly Ser Ile Gly 
1               5                   10                  15      


Trp Ala Val Ile Asn Ile Glu Lys Lys Arg Ile Glu Asp Phe Asn Val 
            20                  25                  30          


Arg Ile Phe Lys Ser Gly Glu Ile Gln Glu Lys Asn Arg Asn Ser Arg 
        35                  40                  45              


Ala Ser Gln Gln Cys Arg Arg Ser Arg Gly Leu Arg Arg Leu Tyr Arg 
    50                  55                  60                  


Arg Lys Ser His Arg Lys Leu Arg Leu Lys Asn Tyr Leu Ser Ile Ile 
65                  70                  75                  80  


Gly Leu Thr Thr Ser Glu Lys Ile Asp Tyr Tyr Tyr Glu Thr Ala Asp 
                85                  90                  95      


Asn Asn Val Ile Gln Leu Arg Asn Lys Gly Leu Ser Glu Lys Leu Thr 
            100                 105                 110         


Pro Glu Glu Ile Ala Ala Cys Leu Ile His Ile Cys Asn Asn Arg Gly 
        115                 120                 125             


Tyr Lys Asp Phe Tyr Glu Val Asn Val Glu Asp Ile Glu Asp Pro Asp 
    130                 135                 140                 


Glu Arg Asn Glu Tyr Lys Glu Glu His Asp Ser Ile Val Leu Ile Ser 
145                 150                 155                 160 


Asn Leu Met Asn Glu Gly Gly Tyr Cys Thr Pro Ala Glu Met Ile Cys 
                165                 170                 175     


Asn Cys Arg Glu Phe Asp Glu Pro Asn Ser Val Tyr Arg Lys Phe His 
            180                 185                 190         


Asn Ser Ala Ala Ser Lys Asn His Tyr Leu Ile Thr Arg His Met Leu 
        195                 200                 205             


Val Lys Glu Val Asp Leu Ile Leu Glu Asn Gln Ser Lys Tyr Tyr Gly 
    210                 215                 220                 


Ile Leu Asp Asp Lys Thr Ile Ala Lys Ile Lys Asp Ile Ile Phe Ala 
225                 230                 235                 240 


Gln Arg Asp Phe Glu Ile Gly Pro Gly Lys Asn Glu Arg Phe Arg Arg 
                245                 250                 255     


Phe Thr Gly Tyr Leu Asp Ser Ile Gly Lys Cys Gln Phe Phe Lys Asp 
            260                 265                 270         


Gln Glu Arg Gly Ser Arg Phe Thr Val Ile Ala Asp Ile Tyr Ala Phe 
        275                 280                 285             


Val Asn Val Leu Ser Gln Tyr Thr Tyr Thr Asn Asn Arg Gly Glu Ser 
    290                 295                 300                 


Val Phe Asp Thr Ser Phe Ala Asn Asp Leu Ile Asn Ser Ala Leu Lys 
305                 310                 315                 320 


Asn Gly Ser Met Asp Lys Arg Glu Leu Lys Ala Ile Ala Lys Ser Tyr 
                325                 330                 335     


His Ile Asp Ile Ser Asp Lys Asn Ser Asp Thr Ser Leu Thr Lys Cys 
            340                 345                 350         


Phe Lys Tyr Ile Lys Val Val Lys Pro Leu Phe Glu Lys Tyr Gly Tyr 
        355                 360                 365             


Asp Trp Asp Lys Leu Ile Glu Asn Tyr Thr Asp Thr Asp Asn Asn Val 
    370                 375                 380                 


Leu Asn Arg Ile Gly Ile Val Leu Ser Gln Ala Gln Thr Pro Lys Arg 
385                 390                 395                 400 


Arg Arg Glu Lys Leu Lys Ala Leu Asn Ile Gly Leu Asp Asp Gly Leu 
                405                 410                 415     


Ile Asn Glu Leu Thr Lys Leu Lys Leu Ser Gly Thr Ala Asn Val Ser 
            420                 425                 430         


Tyr Lys Tyr Met Gln Gly Ser Ile Glu Ala Phe Cys Glu Gly Asp Leu 
        435                 440                 445             


Tyr Gly Lys Tyr Gln Ala Lys Phe Asn Lys Glu Ile Pro Asp Ile Asp 
    450                 455                 460                 


Glu Asn Ala Lys Pro Gln Lys Leu Pro Pro Phe Lys Asn Glu Asp Asp 
465                 470                 475                 480 


Cys Glu Phe Phe Lys Asn Pro Val Val Phe Arg Ser Ile Asn Glu Thr 
                485                 490                 495     


Arg Lys Leu Ile Asn Ala Ile Ile Asp Lys Tyr Gly Tyr Pro Ala Ala 
            500                 505                 510         


Val Asn Ile Glu Thr Ala Asp Glu Leu Asn Lys Thr Phe Glu Asp Arg 
        515                 520                 525             


Ala Ile Asp Thr Lys Arg Asn Asn Asp Asn Gln Lys Glu Asn Asp Arg 
    530                 535                 540                 


Ile Val Lys Glu Ile Ile Glu Cys Ile Lys Cys Asp Glu Val His Ala 
545                 550                 555                 560 


Arg His Leu Ile Glu Lys Tyr Lys Leu Trp Glu Ala Gln Glu Gly Lys 
                565                 570                 575     


Cys Leu Tyr Ser Gly Glu Thr Ile Thr Lys Glu Asp Met Leu Arg Asp 
            580                 585                 590         


Lys Asp Lys Leu Phe Glu Val Asp His Ile Val Pro Tyr Ser Leu Ile 
        595                 600                 605             


Leu Asp Asn Thr Ile Asn Asn Lys Ala Leu Val Tyr Ala Glu Glu Asn 
    610                 615                 620                 


Gln Lys Lys Gly Gln Arg Thr Pro Leu Met Tyr Met Asn Glu Ala Gln 
625                 630                 635                 640 


Ala Ala Asp Tyr Arg Val Arg Val Asn Thr Met Phe Lys Ser Lys Lys 
                645                 650                 655     


Cys Ser Lys Lys Lys Tyr Gln Tyr Leu Met Leu Pro Asp Leu Asn Asp 
            660                 665                 670         


Gln Glu Leu Leu Gly Gly Trp Arg Ser Arg Asn Leu Asn Asp Thr Arg 
        675                 680                 685             


Tyr Ile Cys Lys Tyr Leu Val Asn Tyr Leu Arg Lys Asn Leu Arg Phe 
    690                 695                 700                 


Asp Arg Ser Tyr Glu Ser Ser Asp Glu Asp Asp Leu Lys Ile Arg Asp 
705                 710                 715                 720 


His Tyr Arg Val Phe Pro Val Lys Ser Arg Phe Thr Ser Met Phe Arg 
                725                 730                 735     


Arg Trp Trp Leu Asn Glu Lys Thr Trp Gly Arg Tyr Asp Lys Ala Glu 
            740                 745                 750         


Leu Lys Lys Leu Thr Tyr Leu Asp His Ala Ala Asp Ala Ile Ile Ile 
        755                 760                 765             


Ala Asn Cys Arg Pro Glu Tyr Val Val Leu Ala Gly Glu Lys Leu Lys 
    770                 775                 780                 


Leu Asn Lys Met Tyr His Gln Ala Gly Lys Arg Ile Thr Pro Glu Tyr 
785                 790                 795                 800 


Glu Gln Ser Lys Lys Ala Cys Ile Asp Asn Leu Tyr Lys Leu Phe Arg 
                805                 810                 815     


Met Asp Arg Arg Thr Ala Glu Lys Leu Leu Ser Gly His Gly Arg Leu 
            820                 825                 830         


Thr Pro Ile Ile Pro Asn Leu Ser Glu Glu Val Asp Lys Arg Leu Trp 
        835                 840                 845             


Asp Lys Asn Ile Tyr Glu Gln Phe Trp Lys Asp Asp Lys Asp Lys Lys 
    850                 855                 860                 


Ser Cys Glu Glu Leu Tyr Arg Glu Asn Val Ala Ser Leu Tyr Lys Gly 
865                 870                 875                 880 


Asp Pro Lys Phe Ala Ser Ser Leu Ser Met Pro Val Ile Ser Leu Lys 
                885                 890                 895     


Pro Asp His Lys Tyr Arg Gly Thr Ile Thr Gly Glu Glu Ala Ile Arg 
            900                 905                 910         


Val Lys Glu Ile Asp Gly Lys Leu Ile Lys Leu Lys Arg Lys Ser Ile 
        915                 920                 925             


Ser Glu Ile Thr Ala Glu Ser Ile Asn Ser Ile Tyr Thr Asp Asp Lys 
    930                 935                 940                 


Ile Leu Ile Asp Ser Leu Lys Thr Ile Phe Glu Gln Ala Asp Tyr Lys 
945                 950                 955                 960 


Asp Val Gly Asp Tyr Leu Lys Lys Thr Asn Gln His Phe Phe Thr Thr 
                965                 970                 975     


Ser Ser Gly Lys Arg Val Asn Lys Val Thr Val Ile Glu Lys Val Pro 
            980                 985                 990         


Ser Arg Trp Leu Arg Lys Glu Ile  Asp Asp Asn Asn Phe  Ser Leu Leu 
        995                 1000                 1005             


Asn Asp  Ser Ser Tyr Tyr Cys  Ile Glu Leu Tyr Lys  Asp Ser Lys 
    1010                 1015                 1020             


Gly Asp  Asn Asn Leu Gln Gly  Ile Ala Met Ser Asp  Ile Val His 
    1025                 1030                 1035             


Asp Arg  Lys Thr Lys Lys Leu  Tyr Leu Lys Pro Asp  Phe Asn Tyr 
    1040                 1045                 1050             


Pro Asp  Asp Tyr Tyr Thr His  Val Met Tyr Ile Phe  Pro Gly Asp 
    1055                 1060                 1065             


Tyr Leu  Arg Ile Lys Ser Thr  Ser Lys Lys Ser Gly  Glu Gln Leu 
    1070                 1075                 1080             


Lys Phe  Glu Gly Tyr Phe Ile  Ser Val Lys Asn Val  Asn Glu Asn 
    1085                 1090                 1095             


Ser Phe  Arg Phe Ile Ser Asp  Asn Lys Pro Cys Ala  Lys Asp Lys 
    1100                 1105                 1110             


Arg Val  Ser Ile Thr Lys Lys  Asp Ile Val Ile Lys  Leu Ala Val 
    1115                 1120                 1125             


Asp Leu  Met Gly Lys Val Gln  Gly Glu Asn Asn Gly  Lys Gly Ile 
    1130                 1135                 1140             


Ser Cys  Gly Glu Pro Leu Ser  Leu Leu Lys Glu Lys  Asn 
    1145                 1150                 1155     


<210>  732
<211>  1101
<212>  PRT
<213>  Akkermansia muciniphila ATCC BAA-835

<400>  732

Met Ser Arg Ser Leu Thr Phe Ser Phe Asp Ile Gly Tyr Ala Ser Ile 
1               5                   10                  15      


Gly Trp Ala Val Ile Ala Ser Ala Ser His Asp Asp Ala Asp Pro Ser 
            20                  25                  30          


Val Cys Gly Cys Gly Thr Val Leu Phe Pro Lys Asp Asp Cys Gln Ala 
        35                  40                  45              


Phe Lys Arg Arg Glu Tyr Arg Arg Leu Arg Arg Asn Ile Arg Ser Arg 
    50                  55                  60                  


Arg Val Arg Ile Glu Arg Ile Gly Arg Leu Leu Val Gln Ala Gln Ile 
65                  70                  75                  80  


Ile Thr Pro Glu Met Lys Glu Thr Ser Gly His Pro Ala Pro Phe Tyr 
                85                  90                  95      


Leu Ala Ser Glu Ala Leu Lys Gly His Arg Thr Leu Ala Pro Ile Glu 
            100                 105                 110         


Leu Trp His Val Leu Arg Trp Tyr Ala His Asn Arg Gly Tyr Asp Asn 
        115                 120                 125             


Asn Ala Ser Trp Ser Asn Ser Leu Ser Glu Asp Gly Gly Asn Gly Glu 
    130                 135                 140                 


Asp Thr Glu Arg Val Lys His Ala Gln Asp Leu Met Asp Lys His Gly 
145                 150                 155                 160 


Thr Ala Thr Met Ala Glu Thr Ile Cys Arg Glu Leu Lys Leu Glu Glu 
                165                 170                 175     


Gly Lys Ala Asp Ala Pro Met Glu Val Ser Thr Pro Ala Tyr Lys Asn 
            180                 185                 190         


Leu Asn Thr Ala Phe Pro Arg Leu Ile Val Glu Lys Glu Val Arg Arg 
        195                 200                 205             


Ile Leu Glu Leu Ser Ala Pro Leu Ile Pro Gly Leu Thr Ala Glu Ile 
    210                 215                 220                 


Ile Glu Leu Ile Ala Gln His His Pro Leu Thr Thr Glu Gln Arg Gly 
225                 230                 235                 240 


Val Leu Leu Gln His Gly Ile Lys Leu Ala Arg Arg Tyr Arg Gly Ser 
                245                 250                 255     


Leu Leu Phe Gly Gln Leu Ile Pro Arg Phe Asp Asn Arg Ile Ile Ser 
            260                 265                 270         


Arg Cys Pro Val Thr Trp Ala Gln Val Tyr Glu Ala Glu Leu Lys Lys 
        275                 280                 285             


Gly Asn Ser Glu Gln Ser Ala Arg Glu Arg Ala Glu Lys Leu Ser Lys 
    290                 295                 300                 


Val Pro Thr Ala Asn Cys Pro Glu Phe Tyr Glu Tyr Arg Met Ala Arg 
305                 310                 315                 320 


Ile Leu Cys Asn Ile Arg Ala Asp Gly Glu Pro Leu Ser Ala Glu Ile 
                325                 330                 335     


Arg Arg Glu Leu Met Asn Gln Ala Arg Gln Glu Gly Lys Leu Thr Lys 
            340                 345                 350         


Ala Ser Leu Glu Lys Ala Ile Ser Ser Arg Leu Gly Lys Glu Thr Glu 
        355                 360                 365             


Thr Asn Val Ser Asn Tyr Phe Thr Leu His Pro Asp Ser Glu Glu Ala 
    370                 375                 380                 


Leu Tyr Leu Asn Pro Ala Val Glu Val Leu Gln Arg Ser Gly Ile Gly 
385                 390                 395                 400 


Gln Ile Leu Ser Pro Ser Val Tyr Arg Ile Ala Ala Asn Arg Leu Arg 
                405                 410                 415     


Arg Gly Lys Ser Val Thr Pro Asn Tyr Leu Leu Asn Leu Leu Lys Ser 
            420                 425                 430         


Arg Gly Glu Ser Gly Glu Ala Leu Glu Lys Lys Ile Glu Lys Glu Ser 
        435                 440                 445             


Lys Lys Lys Glu Ala Asp Tyr Ala Asp Thr Pro Leu Lys Pro Lys Tyr 
    450                 455                 460                 


Ala Thr Gly Arg Ala Pro Tyr Ala Arg Thr Val Leu Lys Lys Val Val 
465                 470                 475                 480 


Glu Glu Ile Leu Asp Gly Glu Asp Pro Thr Arg Pro Ala Arg Gly Glu 
                485                 490                 495     


Ala His Pro Asp Gly Glu Leu Lys Ala His Asp Gly Cys Leu Tyr Cys 
            500                 505                 510         


Leu Leu Asp Thr Asp Ser Ser Val Asn Gln His Gln Lys Glu Arg Arg 
        515                 520                 525             


Leu Asp Thr Met Thr Asn Asn His Leu Val Arg His Arg Met Leu Ile 
    530                 535                 540                 


Leu Asp Arg Leu Leu Lys Asp Leu Ile Gln Asp Phe Ala Asp Gly Gln 
545                 550                 555                 560 


Lys Asp Arg Ile Ser Arg Val Cys Val Glu Val Gly Lys Glu Leu Thr 
                565                 570                 575     


Thr Phe Ser Ala Met Asp Ser Lys Lys Ile Gln Arg Glu Leu Thr Leu 
            580                 585                 590         


Arg Gln Lys Ser His Thr Asp Ala Val Asn Arg Leu Lys Arg Lys Leu 
        595                 600                 605             


Pro Gly Lys Ala Leu Ser Ala Asn Leu Ile Arg Lys Cys Arg Ile Ala 
    610                 615                 620                 


Met Asp Met Asn Trp Thr Cys Pro Phe Thr Gly Ala Thr Tyr Gly Asp 
625                 630                 635                 640 


His Glu Leu Glu Asn Leu Glu Leu Glu His Ile Val Pro His Ser Phe 
                645                 650                 655     


Arg Gln Ser Asn Ala Leu Ser Ser Leu Val Leu Thr Trp Pro Gly Val 
            660                 665                 670         


Asn Arg Met Lys Gly Gln Arg Thr Gly Tyr Asp Phe Val Glu Gln Glu 
        675                 680                 685             


Gln Glu Asn Pro Val Pro Asp Lys Pro Asn Leu His Ile Cys Ser Leu 
    690                 695                 700                 


Asn Asn Tyr Arg Glu Leu Val Glu Lys Leu Asp Asp Lys Lys Gly His 
705                 710                 715                 720 


Glu Asp Asp Arg Arg Arg Lys Lys Lys Arg Lys Ala Leu Leu Met Val 
                725                 730                 735     


Arg Gly Leu Ser His Lys His Gln Ser Gln Asn His Glu Ala Met Lys 
            740                 745                 750         


Glu Ile Gly Met Thr Glu Gly Met Met Thr Gln Ser Ser His Leu Met 
        755                 760                 765             


Lys Leu Ala Cys Lys Ser Ile Lys Thr Ser Leu Pro Asp Ala His Ile 
    770                 775                 780                 


Asp Met Ile Pro Gly Ala Val Thr Ala Glu Val Arg Lys Ala Trp Asp 
785                 790                 795                 800 


Val Phe Gly Val Phe Lys Glu Leu Cys Pro Glu Ala Ala Asp Pro Asp 
                805                 810                 815     


Ser Gly Lys Ile Leu Lys Glu Asn Leu Arg Ser Leu Thr His Leu His 
            820                 825                 830         


His Ala Leu Asp Ala Cys Val Leu Gly Leu Ile Pro Tyr Ile Ile Pro 
        835                 840                 845             


Ala His His Asn Gly Leu Leu Arg Arg Val Leu Ala Met Arg Arg Ile 
    850                 855                 860                 


Pro Glu Lys Leu Ile Pro Gln Val Arg Pro Val Ala Asn Gln Arg His 
865                 870                 875                 880 


Tyr Val Leu Asn Asp Asp Gly Arg Met Met Leu Arg Asp Leu Ser Ala 
                885                 890                 895     


Ser Leu Lys Glu Asn Ile Arg Glu Gln Leu Met Glu Gln Arg Val Ile 
            900                 905                 910         


Gln His Val Pro Ala Asp Met Gly Gly Ala Leu Leu Lys Glu Thr Met 
        915                 920                 925             


Gln Arg Val Leu Ser Val Asp Gly Ser Gly Glu Asp Ala Met Val Ser 
    930                 935                 940                 


Leu Ser Lys Lys Lys Asp Gly Lys Lys Glu Lys Asn Gln Val Lys Ala 
945                 950                 955                 960 


Ser Lys Leu Val Gly Val Phe Pro Glu Gly Pro Ser Lys Leu Lys Ala 
                965                 970                 975     


Leu Lys Ala Ala Ile Glu Ile Asp Gly Asn Tyr Gly Val Ala Leu Asp 
            980                 985                 990         


Pro Lys Pro Val Val Ile Arg His  Ile Lys Val Phe Lys  Arg Ile Met 
        995                 1000                 1005             


Ala Leu  Lys Glu Gln Asn Gly  Gly Lys Pro Val Arg  Ile Leu Lys 
    1010                 1015                 1020             


Lys Gly  Met Leu Ile His Leu  Thr Ser Ser Lys Asp  Pro Lys His 
    1025                 1030                 1035             


Ala Gly  Val Trp Arg Ile Glu  Ser Ile Gln Asp Ser  Lys Gly Gly 
    1040                 1045                 1050             


Val Lys  Leu Asp Leu Gln Arg  Ala His Cys Ala Val  Pro Lys Asn 
    1055                 1060                 1065             


Lys Thr  His Glu Cys Asn Trp  Arg Glu Val Asp Leu  Ile Ser Leu 
    1070                 1075                 1080             


Leu Lys  Lys Tyr Gln Met Lys  Arg Tyr Pro Thr Ser  Tyr Thr Gly 
    1085                 1090                 1095             


Thr Pro  Arg 
    1100     


<210>  733
<211>  1138
<212>  PRT
<213>  Acidothermus cellulolyticus 11B

<400>  733

Met Gly Gly Ser Glu Val Gly Thr Val Pro Val Thr Trp Arg Leu Gly 
1               5                   10                  15      


Val Asp Val Gly Glu Arg Ser Ile Gly Leu Ala Ala Val Ser Tyr Glu 
            20                  25                  30          


Glu Asp Lys Pro Lys Glu Ile Leu Ala Ala Val Ser Trp Ile His Asp 
        35                  40                  45              


Gly Gly Val Gly Asp Glu Arg Ser Gly Ala Ser Arg Leu Ala Leu Arg 
    50                  55                  60                  


Gly Met Ala Arg Arg Ala Arg Arg Leu Arg Arg Phe Arg Arg Ala Arg 
65                  70                  75                  80  


Leu Arg Asp Leu Asp Met Leu Leu Ser Glu Leu Gly Trp Thr Pro Leu 
                85                  90                  95      


Pro Asp Lys Asn Val Ser Pro Val Asp Ala Trp Leu Ala Arg Lys Arg 
            100                 105                 110         


Leu Ala Glu Glu Tyr Val Val Asp Glu Thr Glu Arg Arg Arg Leu Leu 
        115                 120                 125             


Gly Tyr Ala Val Ser His Met Ala Arg His Arg Gly Trp Arg Asn Pro 
    130                 135                 140                 


Trp Thr Thr Ile Lys Asp Leu Lys Asn Leu Pro Gln Pro Ser Asp Ser 
145                 150                 155                 160 


Trp Glu Arg Thr Arg Glu Ser Leu Glu Ala Arg Tyr Ser Val Ser Leu 
                165                 170                 175     


Glu Pro Gly Thr Val Gly Gln Trp Ala Gly Tyr Leu Leu Gln Arg Ala 
            180                 185                 190         


Pro Gly Ile Arg Leu Asn Pro Thr Gln Gln Ser Ala Gly Arg Arg Ala 
        195                 200                 205             


Glu Leu Ser Asn Ala Thr Ala Phe Glu Thr Arg Leu Arg Gln Glu Asp 
    210                 215                 220                 


Val Leu Trp Glu Leu Arg Cys Ile Ala Asp Val Gln Gly Leu Pro Glu 
225                 230                 235                 240 


Asp Val Val Ser Asn Val Ile Asp Ala Val Phe Cys Gln Lys Arg Pro 
                245                 250                 255     


Ser Val Pro Ala Glu Arg Ile Gly Arg Asp Pro Leu Asp Pro Ser Gln 
            260                 265                 270         


Leu Arg Ala Ser Arg Ala Cys Leu Glu Phe Gln Glu Tyr Arg Ile Val 
        275                 280                 285             


Ala Ala Val Ala Asn Leu Arg Ile Arg Asp Gly Ser Gly Ser Arg Pro 
    290                 295                 300                 


Leu Ser Leu Glu Glu Arg Asn Ala Val Ile Glu Ala Leu Leu Ala Gln 
305                 310                 315                 320 


Thr Glu Arg Ser Leu Thr Trp Ser Asp Ile Ala Leu Glu Ile Leu Lys 
                325                 330                 335     


Leu Pro Asn Glu Ser Asp Leu Thr Ser Val Pro Glu Glu Asp Gly Pro 
            340                 345                 350         


Ser Ser Leu Ala Tyr Ser Gln Phe Ala Pro Phe Asp Glu Thr Ser Ala 
        355                 360                 365             


Arg Ile Ala Glu Phe Ile Ala Lys Asn Arg Arg Lys Ile Pro Thr Phe 
    370                 375                 380                 


Ala Gln Trp Trp Gln Glu Gln Asp Arg Thr Ser Arg Ser Asp Leu Val 
385                 390                 395                 400 


Ala Ala Leu Ala Asp Asn Ser Ile Ala Gly Glu Glu Glu Gln Glu Leu 
                405                 410                 415     


Leu Val His Leu Pro Asp Ala Glu Leu Glu Ala Leu Glu Gly Leu Ala 
            420                 425                 430         


Leu Pro Ser Gly Arg Val Ala Tyr Ser Arg Leu Thr Leu Ser Gly Leu 
        435                 440                 445             


Thr Arg Val Met Arg Asp Asp Gly Val Asp Val His Asn Ala Arg Lys 
    450                 455                 460                 


Thr Cys Phe Gly Val Asp Asp Asn Trp Arg Pro Pro Leu Pro Ala Leu 
465                 470                 475                 480 


His Glu Ala Thr Gly His Pro Val Val Asp Arg Asn Leu Ala Ile Leu 
                485                 490                 495     


Arg Lys Phe Leu Ser Ser Ala Thr Met Arg Trp Gly Pro Pro Gln Ser 
            500                 505                 510         


Ile Val Val Glu Leu Ala Arg Gly Ala Ser Glu Ser Arg Glu Arg Gln 
        515                 520                 525             


Ala Glu Glu Glu Ala Ala Arg Arg Ala His Arg Lys Ala Asn Asp Arg 
    530                 535                 540                 


Ile Arg Ala Glu Leu Arg Ala Ser Gly Leu Ser Asp Pro Ser Pro Ala 
545                 550                 555                 560 


Asp Leu Val Arg Ala Arg Leu Leu Glu Leu Tyr Asp Cys His Cys Met 
                565                 570                 575     


Tyr Cys Gly Ala Pro Ile Ser Trp Glu Asn Ser Glu Leu Asp His Ile 
            580                 585                 590         


Val Pro Arg Thr Asp Gly Gly Ser Asn Arg His Glu Asn Leu Ala Ile 
        595                 600                 605             


Thr Cys Gly Ala Cys Asn Lys Glu Lys Gly Arg Arg Pro Phe Ala Ser 
    610                 615                 620                 


Trp Ala Glu Thr Ser Asn Arg Val Gln Leu Arg Asp Val Ile Asp Arg 
625                 630                 635                 640 


Val Gln Lys Leu Lys Tyr Ser Gly Asn Met Tyr Trp Thr Arg Asp Glu 
                645                 650                 655     


Phe Ser Arg Tyr Lys Lys Ser Val Val Ala Arg Leu Lys Arg Arg Thr 
            660                 665                 670         


Ser Asp Pro Glu Val Ile Gln Ser Ile Glu Ser Thr Gly Tyr Ala Ala 
        675                 680                 685             


Val Ala Leu Arg Asp Arg Leu Leu Ser Tyr Gly Glu Lys Asn Gly Val 
    690                 695                 700                 


Ala Gln Val Ala Val Phe Arg Gly Gly Val Thr Ala Glu Ala Arg Arg 
705                 710                 715                 720 


Trp Leu Asp Ile Ser Ile Glu Arg Leu Phe Ser Arg Val Ala Ile Phe 
                725                 730                 735     


Ala Gln Ser Thr Ser Thr Lys Arg Leu Asp Arg Arg His His Ala Val 
            740                 745                 750         


Asp Ala Val Val Leu Thr Thr Leu Thr Pro Gly Val Ala Lys Thr Leu 
        755                 760                 765             


Ala Asp Ala Arg Ser Arg Arg Val Ser Ala Glu Phe Trp Arg Arg Pro 
    770                 775                 780                 


Ser Asp Val Asn Arg His Ser Thr Glu Glu Pro Gln Ser Pro Ala Tyr 
785                 790                 795                 800 


Arg Gln Trp Lys Glu Ser Cys Ser Gly Leu Gly Asp Leu Leu Ile Ser 
                805                 810                 815     


Thr Ala Ala Arg Asp Ser Ile Ala Val Ala Ala Pro Leu Arg Leu Arg 
            820                 825                 830         


Pro Thr Gly Ala Leu His Glu Glu Thr Leu Arg Ala Phe Ser Glu His 
        835                 840                 845             


Thr Val Gly Ala Ala Trp Lys Gly Ala Glu Leu Arg Arg Ile Val Glu 
    850                 855                 860                 


Pro Glu Val Tyr Ala Ala Phe Leu Ala Leu Thr Asp Pro Gly Gly Arg 
865                 870                 875                 880 


Phe Leu Lys Val Ser Pro Ser Glu Asp Val Leu Pro Ala Asp Glu Asn 
                885                 890                 895     


Arg His Ile Val Leu Ser Asp Arg Val Leu Gly Pro Arg Asp Arg Val 
            900                 905                 910         


Lys Leu Phe Pro Asp Asp Arg Gly Ser Ile Arg Val Arg Gly Gly Ala 
        915                 920                 925             


Ala Tyr Ile Ala Ser Phe His His Ala Arg Val Phe Arg Trp Gly Ser 
    930                 935                 940                 


Ser His Ser Pro Ser Phe Ala Leu Leu Arg Val Ser Leu Ala Asp Leu 
945                 950                 955                 960 


Ala Val Ala Gly Leu Leu Arg Asp Gly Val Asp Val Phe Thr Ala Glu 
                965                 970                 975     


Leu Pro Pro Trp Thr Pro Ala Trp Arg Tyr Ala Ser Ile Ala Leu Val 
            980                 985                 990         


Lys Ala Val Glu Ser Gly Asp Ala  Lys Gln Val Gly Trp  Leu Val Pro 
        995                 1000                 1005             


Gly Asp  Glu Leu Asp Phe Gly  Pro Glu Gly Val Thr  Thr Ala Ala 
    1010                 1015                 1020             


Gly Asp  Leu Ser Met Phe Leu  Lys Tyr Phe Pro Glu  Arg His Trp 
    1025                 1030                 1035             


Val Val  Thr Gly Phe Glu Asp  Asp Lys Arg Ile Asn  Leu Lys Pro 
    1040                 1045                 1050             


Ala Phe  Leu Ser Ala Glu Gln  Ala Glu Val Leu Arg  Thr Glu Arg 
    1055                 1060                 1065             


Ser Asp  Arg Pro Asp Thr Leu  Thr Glu Ala Gly Glu  Ile Leu Ala 
    1070                 1075                 1080             


Gln Phe  Phe Pro Arg Cys Trp  Arg Ala Thr Val Ala  Lys Val Leu 
    1085                 1090                 1095             


Cys His  Pro Gly Leu Thr Val  Ile Arg Arg Thr Ala  Leu Gly Gln 
    1100                 1105                 1110             


Pro Arg  Trp Arg Arg Gly His  Leu Pro Tyr Ser Trp  Arg Pro Trp 
    1115                 1120                 1125             


Ser Ala  Asp Pro Trp Ser Gly  Gly Thr Pro 
    1130                 1135             


<210>  734
<211>  1187
<212>  PRT
<213>  Bifidobacterium longum DJO10A

<400>  734

Met Leu Ser Arg Gln Leu Leu Gly Ala Ser His Leu Ala Arg Pro Val 
1               5                   10                  15      


Ser Tyr Ser Tyr Asn Val Gln Asp Asn Asp Val His Cys Ser Tyr Gly 
            20                  25                  30          


Glu Arg Cys Phe Met Arg Gly Lys Arg Tyr Arg Ile Gly Ile Asp Val 
        35                  40                  45              


Gly Leu Asn Ser Val Gly Leu Ala Ala Val Glu Val Ser Asp Glu Asn 
    50                  55                  60                  


Ser Pro Val Arg Leu Leu Asn Ala Gln Ser Val Ile His Asp Gly Gly 
65                  70                  75                  80  


Val Asp Pro Gln Lys Asn Lys Glu Ala Ile Thr Arg Lys Asn Met Ser 
                85                  90                  95      


Gly Val Ala Arg Arg Thr Arg Arg Met Arg Arg Arg Lys Arg Glu Arg 
            100                 105                 110         


Leu His Lys Leu Asp Met Leu Leu Gly Lys Phe Gly Tyr Pro Val Ile 
        115                 120                 125             


Glu Pro Glu Ser Leu Asp Lys Pro Phe Glu Glu Trp His Val Arg Ala 
    130                 135                 140                 


Glu Leu Ala Thr Arg Tyr Ile Glu Asp Asp Glu Leu Arg Arg Glu Ser 
145                 150                 155                 160 


Ile Ser Ile Ala Leu Arg His Met Ala Arg His Arg Gly Trp Arg Asn 
                165                 170                 175     


Pro Tyr Arg Gln Val Asp Ser Leu Ile Ser Asp Asn Pro Tyr Ser Lys 
            180                 185                 190         


Gln Tyr Gly Glu Leu Lys Glu Lys Ala Lys Ala Tyr Asn Asp Asp Ala 
        195                 200                 205             


Thr Ala Ala Glu Glu Glu Ser Thr Pro Ala Gln Leu Val Val Ala Met 
    210                 215                 220                 


Leu Asp Ala Gly Tyr Ala Glu Ala Pro Arg Leu Arg Trp Arg Thr Gly 
225                 230                 235                 240 


Ser Lys Lys Pro Asp Ala Glu Gly Tyr Leu Pro Val Arg Leu Met Gln 
                245                 250                 255     


Glu Asp Asn Ala Asn Glu Leu Lys Gln Ile Phe Arg Val Gln Arg Val 
            260                 265                 270         


Pro Ala Asp Glu Trp Lys Pro Leu Phe Arg Ser Val Phe Tyr Ala Val 
        275                 280                 285             


Ser Pro Lys Gly Ser Ala Glu Gln Arg Val Gly Gln Asp Pro Leu Ala 
    290                 295                 300                 


Pro Glu Gln Ala Arg Ala Leu Lys Ala Ser Leu Ala Phe Gln Glu Tyr 
305                 310                 315                 320 


Arg Ile Ala Asn Val Ile Thr Asn Leu Arg Ile Lys Asp Ala Ser Ala 
                325                 330                 335     


Glu Leu Arg Lys Leu Thr Val Asp Glu Lys Gln Ser Ile Tyr Asp Gln 
            340                 345                 350         


Leu Val Ser Pro Ser Ser Glu Asp Ile Thr Trp Ser Asp Leu Cys Asp 
        355                 360                 365             


Phe Leu Gly Phe Lys Arg Ser Gln Leu Lys Gly Val Gly Ser Leu Thr 
    370                 375                 380                 


Glu Asp Gly Glu Glu Arg Ile Ser Ser Arg Pro Pro Arg Leu Thr Ser 
385                 390                 395                 400 


Val Gln Arg Ile Tyr Glu Ser Asp Asn Lys Ile Arg Lys Pro Leu Val 
                405                 410                 415     


Ala Trp Trp Lys Ser Ala Ser Asp Asn Glu His Glu Ala Met Ile Arg 
            420                 425                 430         


Leu Leu Ser Asn Thr Val Asp Ile Asp Lys Val Arg Glu Asp Val Ala 
        435                 440                 445             


Tyr Ala Ser Ala Ile Glu Phe Ile Asp Gly Leu Asp Asp Asp Ala Leu 
    450                 455                 460                 


Thr Lys Leu Asp Ser Val Asp Leu Pro Ser Gly Arg Ala Ala Tyr Ser 
465                 470                 475                 480 


Val Glu Thr Leu Gln Lys Leu Thr Arg Gln Met Leu Thr Thr Asp Asp 
                485                 490                 495     


Asp Leu His Glu Ala Arg Lys Thr Leu Phe Asn Val Thr Asp Ser Trp 
            500                 505                 510         


Arg Pro Pro Ala Asp Pro Ile Gly Glu Pro Leu Gly Asn Pro Ser Val 
        515                 520                 525             


Asp Arg Val Leu Lys Asn Val Asn Arg Tyr Leu Met Asn Cys Gln Gln 
    530                 535                 540                 


Arg Trp Gly Asn Pro Val Ser Val Asn Ile Glu His Val Arg Ser Ser 
545                 550                 555                 560 


Phe Ser Ser Val Ala Phe Ala Arg Lys Asp Lys Arg Glu Tyr Glu Lys 
                565                 570                 575     


Asn Asn Glu Lys Arg Ser Ile Phe Arg Ser Ser Leu Ser Glu Gln Leu 
            580                 585                 590         


Arg Ala Asp Glu Gln Met Glu Lys Val Arg Glu Ser Asp Leu Arg Arg 
        595                 600                 605             


Leu Glu Ala Ile Gln Arg Gln Asn Gly Gln Cys Leu Tyr Cys Gly Arg 
    610                 615                 620                 


Thr Ile Thr Phe Arg Thr Cys Glu Met Asp His Ile Val Pro Arg Lys 
625                 630                 635                 640 


Gly Val Gly Ser Thr Asn Thr Arg Thr Asn Phe Ala Ala Val Cys Ala 
                645                 650                 655     


Glu Cys Asn Arg Met Lys Ser Asn Thr Pro Phe Ala Ile Trp Ala Arg 
            660                 665                 670         


Ser Glu Asp Ala Gln Thr Arg Gly Val Ser Leu Ala Glu Ala Lys Lys 
        675                 680                 685             


Arg Val Thr Met Phe Thr Phe Asn Pro Lys Ser Tyr Ala Pro Arg Glu 
    690                 695                 700                 


Val Lys Ala Phe Lys Gln Ala Val Ile Ala Arg Leu Gln Gln Thr Glu 
705                 710                 715                 720 


Asp Asp Ala Ala Ile Asp Asn Arg Ser Ile Glu Ser Val Ala Trp Met 
                725                 730                 735     


Ala Asp Glu Leu His Arg Arg Ile Asp Trp Tyr Phe Asn Ala Lys Gln 
            740                 745                 750         


Tyr Val Asn Ser Ala Ser Ile Asp Asp Ala Glu Ala Glu Thr Met Lys 
        755                 760                 765             


Thr Thr Val Ser Val Phe Gln Gly Arg Val Thr Ala Ser Ala Arg Arg 
    770                 775                 780                 


Ala Ala Gly Ile Glu Gly Lys Ile His Phe Ile Gly Gln Gln Ser Lys 
785                 790                 795                 800 


Thr Arg Leu Asp Arg Arg His His Ala Val Asp Ala Ser Val Ile Ala 
                805                 810                 815     


Met Met Asn Thr Ala Ala Ala Gln Thr Leu Met Glu Arg Glu Ser Leu 
            820                 825                 830         


Arg Glu Ser Gln Arg Leu Ile Gly Leu Met Pro Gly Glu Arg Ser Trp 
        835                 840                 845             


Lys Glu Tyr Pro Tyr Glu Gly Thr Ser Arg Tyr Glu Ser Phe His Leu 
    850                 855                 860                 


Trp Leu Asp Asn Met Asp Val Leu Leu Glu Leu Leu Asn Asp Ala Leu 
865                 870                 875                 880 


Asp Asn Asp Arg Ile Ala Val Met Gln Ser Gln Arg Tyr Val Leu Gly 
                885                 890                 895     


Asn Ser Ile Ala His Asp Ala Thr Ile His Pro Leu Glu Lys Val Pro 
            900                 905                 910         


Leu Gly Ser Ala Met Ser Ala Asp Leu Ile Arg Arg Ala Ser Thr Pro 
        915                 920                 925             


Ala Leu Trp Cys Ala Leu Thr Arg Leu Pro Asp Tyr Asp Glu Lys Glu 
    930                 935                 940                 


Gly Leu Pro Glu Asp Ser His Arg Glu Ile Arg Val His Asp Thr Arg 
945                 950                 955                 960 


Tyr Ser Ala Asp Asp Glu Met Gly Phe Phe Ala Ser Gln Ala Ala Gln 
                965                 970                 975     


Ile Ala Val Gln Glu Gly Ser Ala Asp Ile Gly Ser Ala Ile His His 
            980                 985                 990         


Ala Arg Val Tyr Arg Cys Trp Lys  Thr Asn Ala Lys Gly  Val Arg Lys 
        995                 1000                 1005             


Tyr Phe  Tyr Gly Met Ile Arg  Val Phe Gln Thr Asp  Leu Leu Arg 
    1010                 1015                 1020             


Ala Cys  His Asp Asp Leu Phe  Thr Val Pro Leu Pro  Pro Gln Ser 
    1025                 1030                 1035             


Ile Ser  Met Arg Tyr Gly Glu  Pro Arg Val Val Gln  Ala Leu Gln 
    1040                 1045                 1050             


Ser Gly  Asn Ala Gln Tyr Leu  Gly Ser Leu Val Val  Gly Asp Glu 
    1055                 1060                 1065             


Ile Glu  Met Asp Phe Ser Ser  Leu Asp Val Asp Gly  Gln Ile Gly 
    1070                 1075                 1080             


Glu Tyr  Leu Gln Phe Phe Ser  Gln Phe Ser Gly Gly  Asn Leu Ala 
    1085                 1090                 1095             


Trp Lys  His Trp Val Val Asp  Gly Phe Phe Asn Gln  Thr Gln Leu 
    1100                 1105                 1110             


Arg Ile  Arg Pro Arg Tyr Leu  Ala Ala Glu Gly Leu  Ala Lys Ala 
    1115                 1120                 1125             


Phe Ser  Asp Asp Val Val Pro  Asp Gly Val Gln Lys  Ile Val Thr 
    1130                 1135                 1140             


Lys Gln  Gly Trp Leu Pro Pro  Val Asn Thr Ala Ser  Lys Thr Ala 
    1145                 1150                 1155             


Val Arg  Ile Val Arg Arg Asn  Ala Phe Gly Glu Pro  Arg Leu Ser 
    1160                 1165                 1170             


Ser Ala  His His Met Pro Cys  Ser Trp Gln Trp Arg  His Glu 
    1175                 1180                 1185         


<210>  735
<211>  1138
<212>  PRT
<213>  Bifidobacterium dentium Bd1

<400>  735

Met Leu Cys Arg Cys His Arg Arg Tyr Arg Ile Gly Ile Asp Val Gly 
1               5                   10                  15      


Leu Met Ser Val Gly Leu Ala Ala Ile Glu Val Asp Glu Thr Gly Phe 
            20                  25                  30          


Pro Ile Arg Ile Leu Asn Ile Gln Ser Val Ile His Asp Gly Gly Ile 
        35                  40                  45              


Asp Pro Gln Leu Gly Lys Lys Lys Ser Ile Ser Arg Lys Ala Ile Ser 
    50                  55                  60                  


Gly Val Ala Arg Arg Thr Arg Arg Met Arg Arg Arg Lys Val Val Arg 
65                  70                  75                  80  


Leu Arg Gln Leu Asp Ala Thr Leu Glu Ser Leu Gly Phe Pro Ile Val 
                85                  90                  95      


Glu Pro Asp Ser Leu Asp Thr Trp Glu Ile Trp Leu Thr Arg Ala Lys 
            100                 105                 110         


Leu Ala Ser Ser Tyr Ile Gln Asp Asp Glu Thr Arg Lys Glu Asp Val 
        115                 120                 125             


Ser Ile Ala Leu Arg His Ile Ala Arg His Arg Gly Trp Arg Asn Pro 
    130                 135                 140                 


Tyr Ser Asn Val Glu Ser Leu Phe Val Asp Val Ala Pro Ser Glu Gln 
145                 150                 155                 160 


Tyr Glu Glu Leu Arg Arg Lys Ala Glu Glu Lys Leu Gly Thr Ser Leu 
                165                 170                 175     


Ser Gly Asn Pro Thr Ser Ala Glu Ile Val Glu Cys Ile Leu Lys Arg 
            180                 185                 190         


Gln Val Gly Glu Val Gln Leu Arg Thr Arg Ser Arg Lys Gly Val Asn 
        195                 200                 205             


Gly Asn Ala Val Glu Lys Glu Gly Leu Leu Pro Thr Lys Leu Met Gln 
    210                 215                 220                 


Ser Asp Asn Ala Ala Glu Ile Arg Arg Ile Phe Lys Val Gln Arg Ile 
225                 230                 235                 240 


Asp Asp Glu Thr Gly Arg Lys Leu Leu Arg Ala Val Phe Lys Ala Cys 
                245                 250                 255     


Ser Pro Lys Gly Ser Val Glu Arg Arg Val Gly Arg Asp Ala Leu Ala 
            260                 265                 270         


Pro Gly Leu Pro Arg Ala Leu Lys Ala Ser Leu Ala Phe Gln Glu Tyr 
        275                 280                 285             


Arg Ile Ala Asn Val Leu Thr Asn Leu Val Ile Ser Glu Asp Gly Thr 
    290                 295                 300                 


Lys Arg Lys Leu Thr Ile Ala Glu Lys Gln Arg Val Phe Gly Phe Leu 
305                 310                 315                 320 


Ser Ser Asn Glu Thr Asp Asp Ile Thr Trp Ile Asp Val Ala Glu Lys 
                325                 330                 335     


Leu Gly Leu Glu Arg Arg Gln Ile Gln Gly Val Gly Cys Leu Thr Ala 
            340                 345                 350         


Asp Gly Glu Glu Arg Ile Ser Ser Thr Pro Pro Arg Asn Ile Thr Ala 
        355                 360                 365             


Leu His Ile His Ser Ala Lys Pro Val Ile Arg Glu Lys Leu Val Ala 
    370                 375                 380                 


Trp Trp Lys Ala Ala Ser Pro Thr Val Arg Glu Thr Met Val Glu Leu 
385                 390                 395                 400 


Leu Ser Asn Thr Val Asp Ile Asp Arg Val Arg Glu Asp Met Asp Tyr 
                405                 410                 415     


Ser Ser Ala Val Ala Phe Ile Asp Ser Leu Gly Asp Glu Glu Leu Thr 
            420                 425                 430         


Ala Leu Asp Ser Val Asp Leu Leu Ser Gly Arg Ala Ala Tyr Ser Arg 
        435                 440                 445             


Gln Thr Leu Lys Gln Leu Thr Glu Arg Met Leu Asn Thr Asp Asp Asp 
    450                 455                 460                 


Leu His Glu Ala Arg Lys Ala Val Phe Gly Val Asp Asp Asn Trp Lys 
465                 470                 475                 480 


Pro Pro Val Asp Ala Ile Ser Thr Ser Val Gly Asn Pro Ala Val Asp 
                485                 490                 495     


Arg Val Leu Lys Ile Val Asn Arg Tyr Leu Leu Ala Cys Gln Lys Arg 
            500                 505                 510         


Trp Arg Asn Pro Gln Ser Val Gln Ile Glu His Val Arg Glu Ser Phe 
        515                 520                 525             


Ser Ser Val Ala Lys Ala Lys Glu Thr Glu Arg Val Gln Gly Glu Arg 
    530                 535                 540                 


Ala Arg Tyr Arg Asn Asp Leu Arg Arg Glu Leu Cys Glu Gln Glu Gly 
545                 550                 555                 560 


Leu Asn Lys Ile Arg Glu Ser Asp Ile Arg Arg Trp Glu Ser Val Gln 
                565                 570                 575     


Arg Gln Asn Gly Thr Cys Leu Tyr Cys Gly Ser Pro Ile Thr Phe Arg 
            580                 585                 590         


Thr Cys Glu Met Asp His Ile Val Pro Arg Lys Gly Val Gly Ser Thr 
        595                 600                 605             


Asn Thr Arg Val Asn Leu Ala Ala Ala Cys Ala Ala Cys Asn Lys Leu 
    610                 615                 620                 


Lys Ser Asn Thr Ala Phe Ser Val Trp Ala Arg Thr Glu Gly Ala Ala 
625                 630                 635                 640 


Asn Arg Lys Val Ser Gln Arg Asp Ala Ile Glu Arg Val Lys Thr Phe 
                645                 650                 655     


Ile Phe Asn Lys Ser Val Pro Pro Arg Glu Gln Arg Ala Phe Lys Gln 
            660                 665                 670         


Ala Val Ile Ser Arg Leu Arg Gln Ala Glu Ser Asp Pro Ala Ile Asp 
        675                 680                 685             


Asn Arg Ser Ile Glu Ser Val Ala Trp Met Ala Asp Glu Leu His Arg 
    690                 695                 700                 


Arg Ile Glu Ala Tyr Phe Asn Gln Asp Ala Asp Val Ser Gly Asn Thr 
705                 710                 715                 720 


Pro Ala Thr Gln Val Trp Val Phe Gln Gly Arg Val Thr Ala Leu Ala 
                725                 730                 735     


Arg Lys Ala Ser Gly Ile Glu Gly Arg Ile His Phe Ala Gly Glu Trp 
            740                 745                 750         


Lys Lys Thr Arg Leu Asp Arg Arg His His Ala Val Asp Ala Ala Val 
        755                 760                 765             


Ile Ala Met Met Asn His Ser Ala Ala Gln Thr Leu Val Glu Arg Asp 
    770                 775                 780                 


Ser Leu Arg Leu Ser Gln Trp Ile Thr Arg Lys Pro Glu Thr Trp Lys 
785                 790                 795                 800 


Asn Tyr Pro Phe Ser Glu Gly Gln Lys Lys Thr Arg Phe Lys Glu Trp 
                805                 810                 815     


Leu Asp Cys Met Asn Ala Leu Leu Asp Leu Leu Asn Asp Ala Leu Asp 
            820                 825                 830         


Ser Asp Arg Val Pro Val Thr Arg Cys Gln Arg Met Ser Leu Gly Asn 
        835                 840                 845             


Ser Gln Ala His Ala Ala Thr Ile Arg Lys Met Lys Arg Val Glu Leu 
    850                 855                 860                 


Phe Ser Pro Met Asp Ala Asp Leu Ile Arg Arg Ala Ser Thr Pro Ala 
865                 870                 875                 880 


Leu Tyr Cys Ala Leu Thr Arg Leu Pro Glu Tyr Ser Pro Glu Lys Gly 
                885                 890                 895     


Leu Pro Glu Asn Arg Gly Arg Glu Ile Val Leu Asn Gly Arg His Ile 
            900                 905                 910         


Arg Ser Thr Glu Thr Val Asp Phe Phe Ala Ser Gly Ala Ala Gln Leu 
        915                 920                 925             


Met Val Arg Asn Gly Ser Ala Glu Ile Gly Asp Ser Ile His His Met 
    930                 935                 940                 


Arg Ile Tyr Arg Tyr Arg Lys Thr Gly Ala Lys Ser Gln Glu Tyr Val 
945                 950                 955                 960 


Tyr Gly Met Ile Arg Val Phe Gln Ile Asp Leu Leu His Ala Ser Ser 
                965                 970                 975     


Glu Asn Leu Phe Ala Val Gln Leu Pro Ser Gln Ser Val Ser Val Arg 
            980                 985                 990         


Tyr Gly Asp Lys Asn Val Val Gln  Ala Ile Gln Glu Gly  Arg Ala Glu 
        995                 1000                 1005             


Tyr Leu  Gly His Ile Val Pro  Asn Asp Glu Ile Leu  Ile Ser Tyr 
    1010                 1015                 1020             


Glu Gly  Val Arg Met Lys Asp  Ser Glu Lys Ile Gly  Ala Tyr Ala 
    1025                 1030                 1035             


Asn Asp  Phe Ser Gly Thr Ala  Ser Glu Leu Ala Gln  Arg Arg His 
    1040                 1045                 1050             


Trp Val  Val Val Gly Ser Asp  Val Ser Lys Leu Ala  Leu Arg Pro 
    1055                 1060                 1065             


Ser Tyr  Leu Ser Glu Glu Gly  Leu Glu Asn Ser Gly  Ser Glu Ser 
    1070                 1075                 1080             


Glu Arg  Leu Ser Lys Gln Thr  Arg Lys Val Ile Glu  Gly Lys Gly 
    1085                 1090                 1095             


Trp Val  Val Ala Val Asn Ile  Leu Ala Lys Tyr His  Pro Val Val 
    1100                 1105                 1110             


Ile Arg  Arg Asn Ala Leu Gly  Glu Pro Arg Phe Arg  Thr Asn Ser 
    1115                 1120                 1125             


Gly Met  Pro Val Ser Trp Arg  Trp Asp Arg 
    1130                 1135             


<210>  736
<211>  1084
<212>  PRT
<213>  Corynebacterium diphtheriae NCTC 13129

<400>  736

Met Lys Tyr His Val Gly Ile Asp Val Gly Thr Phe Ser Val Gly Leu 
1               5                   10                  15      


Ala Ala Ile Glu Val Asp Asp Ala Gly Met Pro Ile Lys Thr Leu Ser 
            20                  25                  30          


Leu Val Ser His Ile His Asp Ser Gly Leu Asp Pro Asp Glu Ile Lys 
        35                  40                  45              


Ser Ala Val Thr Arg Leu Ala Ser Ser Gly Ile Ala Arg Arg Thr Arg 
    50                  55                  60                  


Arg Leu Tyr Arg Arg Lys Arg Arg Arg Leu Gln Gln Leu Asp Lys Phe 
65                  70                  75                  80  


Ile Gln Arg Gln Gly Trp Pro Val Ile Glu Leu Glu Asp Tyr Ser Asp 
                85                  90                  95      


Pro Leu Tyr Pro Trp Lys Val Arg Ala Glu Leu Ala Ala Ser Tyr Ile 
            100                 105                 110         


Ala Asp Glu Lys Glu Arg Gly Glu Lys Leu Ser Val Ala Leu Arg His 
        115                 120                 125             


Ile Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Ala Lys Val Ser Ser 
    130                 135                 140                 


Leu Tyr Leu Pro Asp Gly Pro Ser Asp Ala Phe Lys Ala Ile Arg Glu 
145                 150                 155                 160 


Glu Ile Lys Arg Ala Ser Gly Gln Pro Val Pro Glu Thr Ala Thr Val 
                165                 170                 175     


Gly Gln Met Val Thr Leu Cys Glu Leu Gly Thr Leu Lys Leu Arg Gly 
            180                 185                 190         


Glu Gly Gly Val Leu Ser Ala Arg Leu Gln Gln Ser Asp Tyr Ala Arg 
        195                 200                 205             


Glu Ile Gln Glu Ile Cys Arg Met Gln Glu Ile Gly Gln Glu Leu Tyr 
    210                 215                 220                 


Arg Lys Ile Ile Asp Val Val Phe Ala Ala Glu Ser Pro Lys Gly Ser 
225                 230                 235                 240 


Ala Ser Ser Arg Val Gly Lys Asp Pro Leu Gln Pro Gly Lys Asn Arg 
                245                 250                 255     


Ala Leu Lys Ala Ser Asp Ala Phe Gln Arg Tyr Arg Ile Ala Ala Leu 
            260                 265                 270         


Ile Gly Asn Leu Arg Val Arg Val Asp Gly Glu Lys Arg Ile Leu Ser 
        275                 280                 285             


Val Glu Glu Lys Asn Leu Val Phe Asp His Leu Val Asn Leu Thr Pro 
    290                 295                 300                 


Lys Lys Glu Pro Glu Trp Val Thr Ile Ala Glu Ile Leu Gly Ile Asp 
305                 310                 315                 320 


Arg Gly Gln Leu Ile Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 
                325                 330                 335     


Ala Gly Ala Arg Pro Pro Thr His Asp Thr Asn Arg Ser Ile Val Asn 
            340                 345                 350         


Ser Arg Ile Ala Pro Leu Val Asp Trp Trp Lys Thr Ala Ser Ala Leu 
        355                 360                 365             


Glu Gln His Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp Asp 
    370                 375                 380                 


Phe Asp Ser Pro Glu Gly Ala Lys Val Gln Ala Phe Phe Ala Asp Leu 
385                 390                 395                 400 


Asp Asp Asp Val His Ala Lys Leu Asp Ser Leu His Leu Pro Val Gly 
                405                 410                 415     


Arg Ala Ala Tyr Ser Glu Asp Thr Leu Val Arg Leu Thr Arg Arg Met 
            420                 425                 430         


Leu Ser Asp Gly Val Asp Leu Tyr Thr Ala Arg Leu Gln Glu Phe Gly 
        435                 440                 445             


Ile Glu Pro Ser Trp Thr Pro Pro Thr Pro Arg Ile Gly Glu Pro Val 
    450                 455                 460                 


Gly Asn Pro Ala Val Asp Arg Val Leu Lys Thr Val Ser Arg Trp Leu 
465                 470                 475                 480 


Glu Ser Ala Thr Lys Thr Trp Gly Ala Pro Glu Arg Val Ile Ile Glu 
                485                 490                 495     


His Val Arg Glu Gly Phe Val Thr Glu Lys Arg Ala Arg Glu Met Asp 
            500                 505                 510         


Gly Asp Met Arg Arg Arg Ala Ala Arg Asn Ala Lys Leu Phe Gln Glu 
        515                 520                 525             


Met Gln Glu Lys Leu Asn Val Gln Gly Lys Pro Ser Arg Ala Asp Leu 
    530                 535                 540                 


Trp Arg Tyr Gln Ser Val Gln Arg Gln Asn Cys Gln Cys Ala Tyr Cys 
545                 550                 555                 560 


Gly Ser Pro Ile Thr Phe Ser Asn Ser Glu Met Asp His Ile Val Pro 
                565                 570                 575     


Arg Ala Gly Gln Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Val 
            580                 585                 590         


Cys His Arg Cys Asn Gln Ser Lys Gly Asn Thr Pro Phe Ala Ile Trp 
        595                 600                 605             


Ala Lys Asn Thr Ser Ile Glu Gly Val Ser Val Lys Glu Ala Val Glu 
    610                 615                 620                 


Arg Thr Arg His Trp Val Thr Asp Thr Gly Met Arg Ser Thr Asp Phe 
625                 630                 635                 640 


Lys Lys Phe Thr Lys Ala Val Val Glu Arg Phe Gln Arg Ala Thr Met 
                645                 650                 655     


Asp Glu Glu Ile Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 
            660                 665                 670         


Asn Glu Leu Arg Ser Arg Val Ala Gln His Phe Ala Ser His Gly Thr 
        675                 680                 685             


Thr Val Arg Val Tyr Arg Gly Ser Leu Thr Ala Glu Ala Arg Arg Ala 
    690                 695                 700                 


Ser Gly Ile Ser Gly Lys Leu Lys Phe Phe Asp Gly Val Gly Lys Ser 
705                 710                 715                 720 


Arg Leu Asp Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe 
                725                 730                 735     


Thr Ser Asp Tyr Val Ala Glu Thr Leu Ala Val Arg Ser Asn Leu Lys 
            740                 745                 750         


Gln Ser Gln Ala His Arg Gln Glu Ala Pro Gln Trp Arg Glu Phe Thr 
        755                 760                 765             


Gly Lys Asp Ala Glu His Arg Ala Ala Trp Arg Val Trp Cys Gln Lys 
    770                 775                 780                 


Met Glu Lys Leu Ser Ala Leu Leu Thr Glu Asp Leu Arg Asp Asp Arg 
785                 790                 795                 800 


Val Val Val Met Ser Asn Val Arg Leu Arg Leu Gly Asn Gly Ser Ala 
                805                 810                 815     


His Lys Glu Thr Ile Gly Lys Leu Ser Lys Val Lys Leu Ser Ser Gln 
            820                 825                 830         


Leu Ser Val Ser Asp Ile Asp Lys Ala Ser Ser Glu Ala Leu Trp Cys 
        835                 840                 845             


Ala Leu Thr Arg Glu Pro Gly Phe Asp Pro Lys Glu Gly Leu Pro Ala 
    850                 855                 860                 


Asn Pro Glu Arg His Ile Arg Val Asn Gly Thr His Val Tyr Ala Gly 
865                 870                 875                 880 


Asp Asn Ile Gly Leu Phe Pro Val Ser Ala Gly Ser Ile Ala Leu Arg 
                885                 890                 895     


Gly Gly Tyr Ala Glu Leu Gly Ser Ser Phe His His Ala Arg Val Tyr 
            900                 905                 910         


Lys Ile Thr Ser Gly Lys Lys Pro Ala Phe Ala Met Leu Arg Val Tyr 
        915                 920                 925             


Thr Ile Asp Leu Leu Pro Tyr Arg Asn Gln Asp Leu Phe Ser Val Glu 
    930                 935                 940                 


Leu Lys Pro Gln Thr Met Ser Met Arg Gln Ala Glu Lys Lys Leu Arg 
945                 950                 955                 960 


Asp Ala Leu Ala Thr Gly Asn Ala Glu Tyr Leu Gly Trp Leu Val Val 
                965                 970                 975     


Asp Asp Glu Leu Val Val Asp Thr Ser Lys Ile Ala Thr Asp Gln Val 
            980                 985                 990         


Lys Ala Val Glu Ala Glu Leu Gly  Thr Ile Arg Arg Trp  Arg Val Asp 
        995                 1000                 1005             


Gly Phe  Phe Ser Pro Ser Lys  Leu Arg Leu Arg Pro  Leu Gln Met 
    1010                 1015                 1020             


Ser Lys  Glu Gly Ile Lys Lys  Glu Ser Ala Pro Glu  Leu Ser Lys 
    1025                 1030                 1035             


Ile Ile  Asp Arg Pro Gly Trp  Leu Pro Ala Val Asn  Lys Leu Phe 
    1040                 1045                 1050             


Ser Asp  Gly Asn Val Thr Val  Val Arg Arg Asp Ser  Leu Gly Arg 
    1055                 1060                 1065             


Val Arg  Leu Glu Ser Thr Ala  His Leu Pro Val Thr  Trp Lys Val 
    1070                 1075                 1080             


Gln 
    


<210>  737
<211>  1195
<212>  PRT
<213>  Elusimicrobium minutum Pei191

<400>  737

Met Gln Lys Asn Ile Asn Thr Lys Gln Asn His Ile Tyr Ile Lys Gln 
1               5                   10                  15      


Ala Gln Lys Ile Lys Glu Lys Leu Gly Asp Lys Pro Tyr Arg Ile Gly 
            20                  25                  30          


Leu Asp Leu Gly Val Gly Ser Ile Gly Phe Ala Ile Val Ser Met Glu 
        35                  40                  45              


Glu Asn Asp Gly Asn Val Leu Leu Pro Lys Glu Ile Ile Met Val Gly 
    50                  55                  60                  


Ser Arg Ile Phe Lys Ala Ser Ala Gly Ala Ala Asp Arg Lys Leu Ser 
65                  70                  75                  80  


Arg Gly Gln Arg Asn Asn His Arg His Thr Arg Glu Arg Met Arg Tyr 
                85                  90                  95      


Leu Trp Lys Val Leu Ala Glu Gln Lys Leu Ala Leu Pro Val Pro Ala 
            100                 105                 110         


Asp Leu Asp Arg Lys Glu Asn Ser Ser Glu Gly Glu Thr Ser Ala Lys 
        115                 120                 125             


Arg Phe Leu Gly Asp Val Leu Gln Lys Asp Ile Tyr Glu Leu Arg Val 
    130                 135                 140                 


Lys Ser Leu Asp Glu Arg Leu Ser Leu Gln Glu Leu Gly Tyr Val Leu 
145                 150                 155                 160 


Tyr His Ile Ala Gly His Arg Gly Ser Ser Ala Ile Arg Thr Phe Glu 
                165                 170                 175     


Asn Asp Ser Glu Glu Ala Gln Lys Glu Asn Thr Glu Asn Lys Lys Ile 
            180                 185                 190         


Ala Gly Asn Ile Lys Arg Leu Met Ala Lys Lys Asn Tyr Arg Thr Tyr 
        195                 200                 205             


Gly Glu Tyr Leu Tyr Lys Glu Phe Phe Glu Asn Lys Glu Lys His Lys 
    210                 215                 220                 


Arg Glu Lys Ile Ser Asn Ala Ala Asn Asn His Lys Phe Ser Pro Thr 
225                 230                 235                 240 


Arg Asp Leu Val Ile Lys Glu Ala Glu Ala Ile Leu Lys Lys Gln Ala 
                245                 250                 255     


Gly Lys Asp Gly Phe His Lys Glu Leu Thr Glu Glu Tyr Ile Glu Lys 
            260                 265                 270         


Leu Thr Lys Ala Ile Gly Tyr Glu Ser Glu Lys Leu Ile Pro Glu Ser 
        275                 280                 285             


Gly Phe Cys Pro Tyr Leu Lys Asp Glu Lys Arg Leu Pro Ala Ser His 
    290                 295                 300                 


Lys Leu Asn Glu Glu Arg Arg Leu Trp Glu Thr Leu Asn Asn Ala Arg 
305                 310                 315                 320 


Tyr Ser Asp Pro Ile Val Asp Ile Val Thr Gly Glu Ile Thr Gly Tyr 
                325                 330                 335     


Tyr Glu Lys Gln Phe Thr Lys Glu Gln Lys Gln Lys Leu Phe Asp Tyr 
            340                 345                 350         


Leu Leu Thr Gly Ser Glu Leu Thr Pro Ala Gln Thr Lys Lys Leu Leu 
        355                 360                 365             


Gly Leu Lys Asn Thr Asn Phe Glu Asp Ile Ile Leu Gln Gly Arg Asp 
    370                 375                 380                 


Lys Lys Ala Gln Lys Ile Lys Gly Tyr Lys Leu Ile Lys Leu Glu Ser 
385                 390                 395                 400 


Met Pro Phe Trp Ala Arg Leu Ser Glu Ala Gln Gln Asp Ser Phe Leu 
                405                 410                 415     


Tyr Asp Trp Asn Ser Cys Pro Asp Glu Lys Leu Leu Thr Glu Lys Leu 
            420                 425                 430         


Ser Asn Glu Tyr His Leu Thr Glu Glu Glu Ile Asp Asn Ala Phe Asn 
        435                 440                 445             


Glu Ile Val Leu Ser Ser Ser Tyr Ala Pro Leu Gly Lys Ser Ala Met 
    450                 455                 460                 


Leu Ile Ile Leu Glu Lys Ile Lys Asn Asp Leu Ser Tyr Thr Glu Ala 
465                 470                 475                 480 


Val Glu Glu Ala Leu Lys Glu Gly Lys Leu Thr Lys Glu Lys Gln Ala 
                485                 490                 495     


Ile Lys Asp Arg Leu Pro Tyr Tyr Gly Ala Val Leu Gln Glu Ser Thr 
            500                 505                 510         


Gln Lys Ile Ile Ala Lys Gly Phe Ser Pro Gln Phe Lys Asp Lys Gly 
        515                 520                 525             


Tyr Lys Thr Pro His Thr Asn Lys Tyr Glu Leu Glu Tyr Gly Arg Ile 
    530                 535                 540                 


Ala Asn Pro Val Val His Gln Thr Leu Asn Glu Leu Arg Lys Leu Val 
545                 550                 555                 560 


Asn Glu Ile Ile Asp Ile Leu Gly Lys Lys Pro Cys Glu Ile Gly Leu 
                565                 570                 575     


Glu Thr Ala Arg Glu Leu Lys Lys Ser Ala Glu Asp Arg Ser Lys Leu 
            580                 585                 590         


Ser Arg Glu Gln Asn Asp Asn Glu Ser Asn Arg Asn Arg Ile Tyr Glu 
        595                 600                 605             


Ile Tyr Ile Arg Pro Gln Gln Gln Val Ile Ile Thr Arg Arg Glu Asn 
    610                 615                 620                 


Pro Arg Asn Tyr Ile Leu Lys Phe Glu Leu Leu Glu Glu Gln Lys Ser 
625                 630                 635                 640 


Gln Cys Pro Phe Cys Gly Gly Gln Ile Ser Pro Asn Asp Ile Ile Asn 
                645                 650                 655     


Asn Gln Ala Asp Ile Glu His Leu Phe Pro Ile Ala Glu Ser Glu Asp 
            660                 665                 670         


Asn Gly Arg Asn Asn Leu Val Ile Ser His Ser Ala Cys Asn Ala Asp 
        675                 680                 685             


Lys Ala Lys Arg Ser Pro Trp Ala Ala Phe Ala Ser Ala Ala Lys Asp 
    690                 695                 700                 


Ser Lys Tyr Asp Tyr Asn Arg Ile Leu Ser Asn Val Lys Glu Asn Ile 
705                 710                 715                 720 


Pro His Lys Ala Trp Arg Phe Asn Gln Gly Ala Phe Glu Lys Phe Ile 
                725                 730                 735     


Glu Asn Lys Pro Met Ala Ala Arg Phe Lys Thr Asp Asn Ser Tyr Ile 
            740                 745                 750         


Ser Lys Val Ala His Lys Tyr Leu Ala Cys Leu Phe Glu Lys Pro Asn 
        755                 760                 765             


Ile Ile Cys Val Lys Gly Ser Leu Thr Ala Gln Leu Arg Met Ala Trp 
    770                 775                 780                 


Gly Leu Gln Gly Leu Met Ile Pro Phe Ala Lys Gln Leu Ile Thr Glu 
785                 790                 795                 800 


Lys Glu Ser Glu Ser Phe Asn Lys Asp Val Asn Ser Asn Lys Lys Ile 
                805                 810                 815     


Arg Leu Asp Asn Arg His His Ala Leu Asp Ala Ile Val Ile Ala Tyr 
            820                 825                 830         


Ala Ser Arg Gly Tyr Gly Asn Leu Leu Asn Lys Met Ala Gly Lys Asp 
        835                 840                 845             


Tyr Lys Ile Asn Tyr Ser Glu Arg Asn Trp Leu Ser Lys Ile Leu Leu 
    850                 855                 860                 


Pro Pro Asn Asn Ile Val Trp Glu Asn Ile Asp Ala Asp Leu Glu Ser 
865                 870                 875                 880 


Phe Glu Ser Ser Val Lys Thr Ala Leu Lys Asn Ala Phe Ile Ser Val 
                885                 890                 895     


Lys His Asp His Ser Asp Asn Gly Glu Leu Val Lys Gly Thr Met Tyr 
            900                 905                 910         


Lys Ile Phe Tyr Ser Glu Arg Gly Tyr Thr Leu Thr Thr Tyr Lys Lys 
        915                 920                 925             


Leu Ser Ala Leu Lys Leu Thr Asp Pro Gln Lys Lys Lys Thr Pro Lys 
    930                 935                 940                 


Asp Phe Leu Glu Thr Ala Leu Leu Lys Phe Lys Gly Arg Glu Ser Glu 
945                 950                 955                 960 


Met Lys Asn Glu Lys Ile Lys Ser Ala Ile Glu Asn Asn Lys Arg Leu 
                965                 970                 975     


Phe Asp Val Ile Gln Asp Asn Leu Glu Lys Ala Lys Lys Leu Leu Glu 
            980                 985                 990         


Glu Glu Asn Glu Lys Ser Lys Ala  Glu Gly Lys Lys Glu  Lys Asn Ile 
        995                 1000                 1005             


Asn Asp  Ala Ser Ile Tyr Gln  Lys Ala Ile Ser Leu  Ser Gly Asp 
    1010                 1015                 1020             


Lys Tyr  Val Gln Leu Ser Lys  Lys Glu Pro Gly Lys  Phe Phe Ala 
    1025                 1030                 1035             


Ile Ser  Lys Pro Thr Pro Thr  Thr Thr Gly Tyr Gly  Tyr Asp Thr 
    1040                 1045                 1050             


Gly Asp  Ser Leu Cys Val Asp  Leu Tyr Tyr Asp Asn  Lys Gly Lys 
    1055                 1060                 1065             


Leu Cys  Gly Glu Ile Ile Arg  Lys Ile Asp Ala Gln  Gln Lys Asn 
    1070                 1075                 1080             


Pro Leu  Lys Tyr Lys Glu Gln  Gly Phe Thr Leu Phe  Glu Arg Ile 
    1085                 1090                 1095             


Tyr Gly  Gly Asp Ile Leu Glu  Val Asp Phe Asp Ile  His Ser Asp 
    1100                 1105                 1110             


Lys Asn  Ser Phe Arg Asn Asn  Thr Gly Ser Ala Pro  Glu Asn Arg 
    1115                 1120                 1125             


Val Phe  Ile Lys Val Gly Thr  Phe Thr Glu Ile Thr  Asn Asn Asn 
    1130                 1135                 1140             


Ile Gln  Ile Trp Phe Gly Asn  Ile Ile Lys Ser Thr  Gly Gly Gln 
    1145                 1150                 1155             


Asp Asp  Ser Phe Thr Ile Asn  Ser Met Gln Gln Tyr  Asn Pro Arg 
    1160                 1165                 1170             


Lys Leu  Ile Leu Ser Ser Cys  Gly Phe Ile Lys Tyr  Arg Ser Pro 
    1175                 1180                 1185             


Ile Leu  Lys Asn Lys Glu Gly  
    1190                 1195 


<210>  738
<211>  1132
<212>  PRT
<213>  Nitratifractor salsuginis DSM 16511

<400>  738

Met Lys Lys Ile Leu Gly Val Asp Leu Gly Ile Thr Ser Phe Gly Tyr 
1               5                   10                  15      


Ala Ile Leu Gln Glu Thr Gly Lys Asp Leu Tyr Arg Cys Leu Asp Asn 
            20                  25                  30          


Ser Val Val Met Arg Asn Asn Pro Tyr Asp Glu Lys Ser Gly Glu Ser 
        35                  40                  45              


Ser Gln Ser Ile Arg Ser Thr Gln Lys Ser Met Arg Arg Leu Ile Glu 
    50                  55                  60                  


Lys Arg Lys Lys Arg Ile Arg Cys Val Ala Gln Thr Met Glu Arg Tyr 
65                  70                  75                  80  


Gly Ile Leu Asp Tyr Ser Glu Thr Met Lys Ile Asn Asp Pro Lys Asn 
                85                  90                  95      


Asn Pro Ile Lys Asn Arg Trp Gln Leu Arg Ala Val Asp Ala Trp Lys 
            100                 105                 110         


Arg Pro Leu Ser Pro Gln Glu Leu Phe Ala Ile Phe Ala His Met Ala 
        115                 120                 125             


Lys His Arg Gly Tyr Lys Ser Ile Ala Thr Glu Asp Leu Ile Tyr Glu 
    130                 135                 140                 


Leu Glu Leu Glu Leu Gly Leu Asn Asp Pro Glu Lys Glu Ser Glu Lys 
145                 150                 155                 160 


Lys Ala Asp Glu Arg Arg Gln Val Tyr Asn Ala Leu Arg His Leu Glu 
                165                 170                 175     


Glu Leu Arg Lys Lys Tyr Gly Gly Glu Thr Ile Ala Gln Thr Ile His 
            180                 185                 190         


Arg Ala Val Glu Ala Gly Asp Leu Arg Ser Tyr Arg Asn His Asp Asp 
        195                 200                 205             


Tyr Glu Lys Met Ile Arg Arg Glu Asp Ile Glu Glu Glu Ile Glu Lys 
    210                 215                 220                 


Val Leu Leu Arg Gln Ala Glu Leu Gly Ala Leu Gly Leu Pro Glu Glu 
225                 230                 235                 240 


Gln Val Ser Glu Leu Ile Asp Glu Leu Lys Ala Cys Ile Thr Asp Gln 
                245                 250                 255     


Glu Met Pro Thr Ile Asp Glu Ser Leu Phe Gly Lys Cys Thr Phe Tyr 
            260                 265                 270         


Lys Asp Glu Leu Ala Ala Pro Ala Tyr Ser Tyr Leu Tyr Asp Leu Tyr 
        275                 280                 285             


Arg Leu Tyr Lys Lys Leu Ala Asp Leu Asn Ile Asp Gly Tyr Glu Val 
    290                 295                 300                 


Thr Gln Glu Asp Arg Glu Lys Val Ile Glu Trp Val Glu Lys Lys Ile 
305                 310                 315                 320 


Ala Gln Gly Lys Asn Leu Lys Lys Ile Thr His Lys Asp Leu Arg Lys 
                325                 330                 335     


Ile Leu Gly Leu Ala Pro Glu Gln Lys Ile Phe Gly Val Glu Asp Glu 
            340                 345                 350         


Arg Ile Val Lys Gly Lys Lys Glu Pro Arg Thr Phe Val Pro Phe Phe 
        355                 360                 365             


Phe Leu Ala Asp Ile Ala Lys Phe Lys Glu Leu Phe Ala Ser Ile Gln 
    370                 375                 380                 


Lys His Pro Asp Ala Leu Gln Ile Phe Arg Glu Leu Ala Glu Ile Leu 
385                 390                 395                 400 


Gln Arg Ser Lys Thr Pro Gln Glu Ala Leu Asp Arg Leu Arg Ala Leu 
                405                 410                 415     


Met Ala Gly Lys Gly Ile Asp Thr Asp Asp Arg Glu Leu Leu Glu Leu 
            420                 425                 430         


Phe Lys Asn Lys Arg Ser Gly Thr Arg Glu Leu Ser His Arg Tyr Ile 
        435                 440                 445             


Leu Glu Ala Leu Pro Leu Phe Leu Glu Gly Tyr Asp Glu Lys Glu Val 
    450                 455                 460                 


Gln Arg Ile Leu Gly Phe Asp Asp Arg Glu Asp Tyr Ser Arg Tyr Pro 
465                 470                 475                 480 


Lys Ser Leu Arg His Leu His Leu Arg Glu Gly Asn Leu Phe Glu Lys 
                485                 490                 495     


Glu Glu Asn Pro Ile Asn Asn His Ala Val Lys Ser Leu Ala Ser Trp 
            500                 505                 510         


Ala Leu Gly Leu Ile Ala Asp Leu Ser Trp Arg Tyr Gly Pro Phe Asp 
        515                 520                 525             


Glu Ile Ile Leu Glu Thr Thr Arg Asp Ala Leu Pro Glu Lys Ile Arg 
    530                 535                 540                 


Lys Glu Ile Asp Lys Ala Met Arg Glu Arg Glu Lys Ala Leu Asp Lys 
545                 550                 555                 560 


Ile Ile Gly Lys Tyr Lys Lys Glu Phe Pro Ser Ile Asp Lys Arg Leu 
                565                 570                 575     


Ala Arg Lys Ile Gln Leu Trp Glu Arg Gln Lys Gly Leu Asp Leu Tyr 
            580                 585                 590         


Ser Gly Lys Val Ile Asn Leu Ser Gln Leu Leu Asp Gly Ser Ala Asp 
        595                 600                 605             


Ile Glu His Ile Val Pro Gln Ser Leu Gly Gly Leu Ser Thr Asp Tyr 
    610                 615                 620                 


Asn Thr Ile Val Thr Leu Lys Ser Val Asn Ala Ala Lys Gly Asn Arg 
625                 630                 635                 640 


Leu Pro Gly Asp Trp Leu Ala Gly Asn Pro Asp Tyr Arg Glu Arg Ile 
                645                 650                 655     


Gly Met Leu Ser Glu Lys Gly Leu Ile Asp Trp Lys Lys Arg Lys Asn 
            660                 665                 670         


Leu Leu Ala Gln Ser Leu Asp Glu Ile Tyr Thr Glu Asn Thr His Ser 
        675                 680                 685             


Lys Gly Ile Arg Ala Thr Ser Tyr Leu Glu Ala Leu Val Ala Gln Val 
    690                 695                 700                 


Leu Lys Arg Tyr Tyr Pro Phe Pro Asp Pro Glu Leu Arg Lys Asn Gly 
705                 710                 715                 720 


Ile Gly Val Arg Met Ile Pro Gly Lys Val Thr Ser Lys Thr Arg Ser 
                725                 730                 735     


Leu Leu Gly Ile Lys Ser Lys Ser Arg Glu Thr Asn Phe His His Ala 
            740                 745                 750         


Glu Asp Ala Leu Ile Leu Ser Thr Leu Thr Arg Gly Trp Gln Asn Arg 
        755                 760                 765             


Leu His Arg Met Leu Arg Asp Asn Tyr Gly Lys Ser Glu Ala Glu Leu 
    770                 775                 780                 


Lys Glu Leu Trp Lys Lys Tyr Met Pro His Ile Glu Gly Leu Thr Leu 
785                 790                 795                 800 


Ala Asp Tyr Ile Asp Glu Ala Phe Arg Arg Phe Met Ser Lys Gly Glu 
                805                 810                 815     


Glu Ser Leu Phe Tyr Arg Asp Met Phe Asp Thr Ile Arg Ser Ile Ser 
            820                 825                 830         


Tyr Trp Val Asp Lys Lys Pro Leu Ser Ala Ser Ser His Lys Glu Thr 
        835                 840                 845             


Val Tyr Ser Ser Arg His Glu Val Pro Thr Leu Arg Lys Asn Ile Leu 
    850                 855                 860                 


Glu Ala Phe Asp Ser Leu Asn Val Ile Lys Asp Arg His Lys Leu Thr 
865                 870                 875                 880 


Thr Glu Glu Phe Met Lys Arg Tyr Asp Lys Glu Ile Arg Gln Lys Leu 
                885                 890                 895     


Trp Leu His Arg Ile Gly Asn Thr Asn Asp Glu Ser Tyr Arg Ala Val 
            900                 905                 910         


Glu Glu Arg Ala Thr Gln Ile Ala Gln Ile Leu Thr Arg Tyr Gln Leu 
        915                 920                 925             


Met Asp Ala Gln Asn Asp Lys Glu Ile Asp Glu Lys Phe Gln Gln Ala 
    930                 935                 940                 


Leu Lys Glu Leu Ile Thr Ser Pro Ile Glu Val Thr Gly Lys Leu Leu 
945                 950                 955                 960 


Arg Lys Met Arg Phe Val Tyr Asp Lys Leu Asn Ala Met Gln Ile Asp 
                965                 970                 975     


Arg Gly Leu Val Glu Thr Asp Lys Asn Met Leu Gly Ile His Ile Ser 
            980                 985                 990         


Lys Gly Pro Asn Glu Lys Leu Ile  Phe Arg Arg Met Asp  Val Asn Asn 
        995                 1000                 1005             


Ala His  Glu Leu Gln Lys Glu  Arg Ser Gly Ile Leu  Cys Tyr Leu 
    1010                 1015                 1020             


Asn Glu  Met Leu Phe Ile Phe  Asn Lys Lys Gly Leu  Ile His Tyr 
    1025                 1030                 1035             


Gly Cys  Leu Arg Ser Tyr Leu  Glu Lys Gly Gln Gly  Ser Lys Tyr 
    1040                 1045                 1050             


Ile Ala  Leu Phe Asn Pro Arg  Phe Pro Ala Asn Pro  Lys Ala Gln 
    1055                 1060                 1065             


Pro Ser  Lys Phe Thr Ser Asp  Ser Lys Ile Lys Gln  Val Gly Ile 
    1070                 1075                 1080             


Gly Ser  Ala Thr Gly Ile Ile  Lys Ala His Leu Asp  Leu Asp Gly 
    1085                 1090                 1095             


His Val  Arg Ser Tyr Glu Val  Phe Gly Thr Leu Pro  Glu Gly Ser 
    1100                 1105                 1110             


Ile Glu  Trp Phe Lys Glu Glu  Ser Gly Tyr Gly Arg  Val Glu Asp 
    1115                 1120                 1125             


Asp Pro  His His 
    1130         


<210>  739
<211>  1179
<212>  PRT
<213>  Sphaerochaeta globus str. Buddy

<400>  739

Met Ser Lys Lys Val Ser Arg Arg Tyr Glu Glu Gln Ala Gln Glu Ile 
1               5                   10                  15      


Cys Gln Arg Leu Gly Ser Arg Pro Tyr Ser Ile Gly Leu Asp Leu Gly 
            20                  25                  30          


Val Gly Ser Ile Gly Val Ala Val Ala Ala Tyr Asp Pro Ile Lys Lys 
        35                  40                  45              


Gln Pro Ser Asp Leu Val Phe Val Ser Ser Arg Ile Phe Ile Pro Ser 
    50                  55                  60                  


Thr Gly Ala Ala Glu Arg Arg Gln Lys Arg Gly Gln Arg Asn Ser Leu 
65                  70                  75                  80  


Arg His Arg Ala Asn Arg Leu Lys Phe Leu Trp Lys Leu Leu Ala Glu 
                85                  90                  95      


Arg Asn Leu Met Leu Ser Tyr Ser Glu Gln Asp Val Pro Asp Pro Ala 
            100                 105                 110         


Arg Leu Arg Phe Glu Asp Ala Val Val Arg Ala Asn Pro Tyr Glu Leu 
        115                 120                 125             


Arg Leu Lys Gly Leu Asn Glu Gln Leu Thr Leu Ser Glu Leu Gly Tyr 
    130                 135                 140                 


Ala Leu Tyr His Ile Ala Asn His Arg Gly Ser Ser Ser Val Arg Thr 
145                 150                 155                 160 


Phe Leu Asp Glu Glu Lys Ser Ser Asp Asp Lys Lys Leu Glu Glu Gln 
                165                 170                 175     


Gln Ala Met Thr Glu Gln Leu Ala Lys Glu Lys Gly Ile Ser Thr Phe 
            180                 185                 190         


Ile Glu Val Leu Thr Ala Phe Asn Thr Asn Gly Leu Ile Gly Tyr Arg 
        195                 200                 205             


Asn Ser Glu Ser Val Lys Ser Lys Gly Val Pro Val Pro Thr Arg Asp 
    210                 215                 220                 


Ile Ile Ser Asn Glu Ile Asp Val Leu Leu Gln Thr Gln Lys Gln Phe 
225                 230                 235                 240 


Tyr Gln Glu Ile Leu Ser Asp Glu Tyr Cys Asp Arg Ile Val Ser Ala 
                245                 250                 255     


Ile Leu Phe Glu Asn Glu Lys Ile Val Pro Glu Ala Gly Cys Cys Pro 
            260                 265                 270         


Tyr Phe Pro Asp Glu Lys Lys Leu Pro Arg Cys His Phe Leu Asn Glu 
        275                 280                 285             


Glu Arg Arg Leu Trp Glu Ala Ile Asn Asn Ala Arg Ile Lys Met Pro 
    290                 295                 300                 


Met Gln Glu Gly Ala Ala Lys Arg Tyr Gln Ser Ala Ser Phe Ser Asp 
305                 310                 315                 320 


Glu Gln Arg His Ile Leu Phe His Ile Ala Arg Ser Gly Thr Asp Ile 
                325                 330                 335     


Thr Pro Lys Leu Val Gln Lys Glu Phe Pro Ala Leu Lys Thr Ser Ile 
            340                 345                 350         


Ile Val Leu Gln Gly Lys Glu Lys Ala Ile Gln Lys Ile Ala Gly Phe 
        355                 360                 365             


Arg Phe Arg Arg Leu Glu Glu Lys Ser Phe Trp Lys Arg Leu Ser Glu 
    370                 375                 380                 


Glu Gln Lys Asp Asp Phe Phe Ser Ala Trp Thr Asn Thr Pro Asp Asp 
385                 390                 395                 400 


Lys Arg Leu Ser Lys Tyr Leu Met Lys His Leu Leu Leu Thr Glu Asn 
                405                 410                 415     


Glu Val Val Asp Ala Leu Lys Thr Val Ser Leu Ile Gly Asp Tyr Gly 
            420                 425                 430         


Pro Ile Gly Lys Thr Ala Thr Gln Leu Leu Met Lys His Leu Glu Asp 
        435                 440                 445             


Gly Leu Thr Tyr Thr Glu Ala Leu Glu Arg Gly Met Glu Thr Gly Glu 
    450                 455                 460                 


Phe Gln Glu Leu Ser Val Trp Glu Gln Gln Ser Leu Leu Pro Tyr Tyr 
465                 470                 475                 480 


Gly Gln Ile Leu Thr Gly Ser Thr Gln Ala Leu Met Gly Lys Tyr Trp 
                485                 490                 495     


His Ser Ala Phe Lys Glu Lys Arg Asp Ser Glu Gly Phe Phe Lys Pro 
            500                 505                 510         


Asn Thr Asn Ser Asp Glu Glu Lys Tyr Gly Arg Ile Ala Asn Pro Val 
        515                 520                 525             


Val His Gln Thr Leu Asn Glu Leu Arg Lys Leu Met Asn Glu Leu Ile 
    530                 535                 540                 


Thr Ile Leu Gly Ala Lys Pro Gln Glu Ile Thr Val Glu Leu Ala Arg 
545                 550                 555                 560 


Glu Leu Lys Val Gly Ala Glu Lys Arg Glu Asp Ile Ile Lys Gln Gln 
                565                 570                 575     


Thr Lys Gln Glu Lys Glu Ala Val Leu Ala Tyr Ser Lys Tyr Cys Glu 
            580                 585                 590         


Pro Asn Asn Leu Asp Lys Arg Tyr Ile Glu Arg Phe Arg Leu Leu Glu 
        595                 600                 605             


Asp Gln Ala Phe Val Cys Pro Tyr Cys Leu Glu His Ile Ser Val Ala 
    610                 615                 620                 


Asp Ile Ala Ala Gly Arg Ala Asp Val Asp His Ile Phe Pro Arg Asp 
625                 630                 635                 640 


Asp Thr Ala Asp Asn Ser Tyr Gly Asn Lys Val Val Ala His Arg Gln 
                645                 650                 655     


Cys Asn Asp Ile Lys Gly Lys Arg Thr Pro Tyr Ala Ala Phe Ser Asn 
            660                 665                 670         


Thr Ser Ala Trp Gly Pro Ile Met His Tyr Leu Asp Glu Thr Pro Gly 
        675                 680                 685             


Met Trp Arg Lys Arg Arg Lys Phe Glu Thr Asn Glu Glu Glu Tyr Ala 
    690                 695                 700                 


Lys Tyr Leu Gln Ser Lys Gly Phe Val Ser Arg Phe Glu Ser Asp Asn 
705                 710                 715                 720 


Ser Tyr Ile Ala Lys Ala Ala Lys Glu Tyr Leu Arg Cys Leu Phe Asn 
                725                 730                 735     


Pro Asn Asn Val Thr Ala Val Gly Ser Leu Lys Gly Met Glu Thr Ser 
            740                 745                 750         


Ile Leu Arg Lys Ala Trp Asn Leu Gln Gly Ile Asp Asp Leu Leu Gly 
        755                 760                 765             


Ser Arg His Trp Ser Lys Asp Ala Asp Thr Ser Pro Thr Met Arg Lys 
    770                 775                 780                 


Asn Arg Asp Asp Asn Arg His His Gly Leu Asp Ala Ile Val Ala Leu 
785                 790                 795                 800 


Tyr Cys Ser Arg Ser Leu Val Gln Met Ile Asn Thr Met Ser Glu Gln 
                805                 810                 815     


Gly Lys Arg Ala Val Glu Ile Glu Ala Met Ile Pro Ile Pro Gly Tyr 
            820                 825                 830         


Ala Ser Glu Pro Asn Leu Ser Phe Glu Ala Gln Arg Glu Leu Phe Arg 
        835                 840                 845             


Lys Lys Ile Leu Glu Phe Met Asp Leu His Ala Phe Val Ser Met Lys 
    850                 855                 860                 


Thr Asp Asn Asp Ala Asn Gly Ala Leu Leu Lys Asp Thr Val Tyr Ser 
865                 870                 875                 880 


Ile Leu Gly Ala Asp Thr Gln Gly Glu Asp Leu Val Phe Val Val Lys 
                885                 890                 895     


Lys Lys Ile Lys Asp Ile Gly Val Lys Ile Gly Asp Tyr Glu Glu Val 
            900                 905                 910         


Ala Ser Ala Ile Arg Gly Arg Ile Thr Asp Lys Gln Pro Lys Trp Tyr 
        915                 920                 925             


Pro Met Glu Met Lys Asp Lys Ile Glu Gln Leu Gln Ser Lys Asn Glu 
    930                 935                 940                 


Ala Ala Leu Gln Lys Tyr Lys Glu Ser Leu Val Gln Ala Ala Ala Val 
945                 950                 955                 960 


Leu Glu Glu Ser Asn Arg Lys Leu Ile Glu Ser Gly Lys Lys Pro Ile 
                965                 970                 975     


Gln Leu Ser Glu Lys Thr Ile Ser Lys Lys Ala Leu Glu Leu Val Gly 
            980                 985                 990         


Gly Tyr Tyr Tyr Leu Ile Ser Asn  Asn Lys Arg Thr Lys  Thr Phe Val 
        995                 1000                 1005             


Val Lys  Glu Pro Ser Asn Glu  Val Lys Gly Phe Ala  Phe Asp Thr 
    1010                 1015                 1020             


Gly Ser  Asn Leu Cys Leu Asp  Phe Tyr His Asp Ala  Gln Gly Lys 
    1025                 1030                 1035             


Leu Cys  Gly Glu Ile Ile Arg  Lys Ile Gln Ala Met  Asn Pro Ser 
    1040                 1045                 1050             


Tyr Lys  Pro Ala Tyr Met Lys  Gln Gly Tyr Ser Leu  Tyr Val Arg 
    1055                 1060                 1065             


Leu Tyr  Gln Gly Asp Val Cys  Glu Leu Arg Ala Ser  Asp Leu Thr 
    1070                 1075                 1080             


Glu Ala  Glu Ser Asn Leu Ala  Lys Thr Thr His Val  Arg Leu Pro 
    1085                 1090                 1095             


Asn Ala  Lys Pro Gly Arg Thr  Phe Val Ile Ile Ile  Thr Phe Thr 
    1100                 1105                 1110             


Glu Met  Gly Ser Gly Tyr Gln  Ile Tyr Phe Ser Asn  Leu Ala Lys 
    1115                 1120                 1125             


Ser Lys  Lys Gly Gln Asp Thr  Ser Phe Thr Leu Thr  Thr Ile Lys 
    1130                 1135                 1140             


Asn Tyr  Asp Val Arg Lys Val  Gln Leu Ser Ser Ala  Gly Leu Val 
    1145                 1150                 1155             


Arg Tyr  Val Ser Pro Leu Leu  Val Asp Lys Ile Glu  Lys Asp Glu 
    1160                 1165                 1170             


Val Ala  Leu Cys Gly Glu 
    1175                 


<210>  740
<211>  1512
<212>  PRT
<213>  Fibrobacter succinogenes subsp. succinogenes S85

<400>  740

Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Val Asn Ala Asp Glu Ile Thr Arg Asp Asp Gly Ser Arg Tyr 
            20                  25                  30          


Leu Lys Pro Asn Gly Ile Ser Ala Ala Gly Ser Arg Ile Ile Pro Met 
        35                  40                  45              


Ser Ala Asp Ile Leu Gly Asp Phe Glu Lys Gly Asn Ser Ile Ser Gln 
    50                  55                  60                  


Thr Ala Glu Arg Thr Arg Met Arg Met Ala Arg Arg Leu His Glu Arg 
65                  70                  75                  80  


Ala Leu Leu Arg Arg Glu Arg Leu Leu Arg Val Leu Asn Leu Leu Asp 
                85                  90                  95      


Phe Leu Pro Lys His Phe Ala Asp Lys Ile Asp Arg Tyr Gly Lys Phe 
            100                 105                 110         


Thr Asp Asp Ser Glu Pro Lys Leu Ala Trp Arg Lys Asn Thr Glu Gly 
        115                 120                 125             


Lys Tyr Glu Phe Ile Phe Gln Asp Ala Phe Asn Glu Met Leu Ala Glu 
    130                 135                 140                 


Phe Lys Asp Lys Gln Pro Glu Ile Val Glu Glu Gly Lys Lys Ile Pro 
145                 150                 155                 160 


Tyr Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Glu Lys Ala 
                165                 170                 175     


Leu Ser Lys Glu Glu Leu Ser Trp Ile Leu Leu Gln Phe Asn Gln Lys 
            180                 185                 190         


Arg Gly Tyr Tyr Gln Leu Arg Gly Glu Glu Glu Glu Ile Pro Gln Asp 
        195                 200                 205             


Lys Lys Ile Glu Tyr Leu Ala Gln Lys Val Val Lys Val Glu Ala Thr 
    210                 215                 220                 


Asp Gln Lys Lys Gly Asp Asp Val Trp Tyr Asn Val Tyr Leu Glu Asn 
225                 230                 235                 240 


Gly Met Ile Tyr Arg Arg Thr Ser Lys Ala Pro Leu Asp Trp Glu Gly 
                245                 250                 255     


Lys Val Lys Glu Phe Ile Val Thr Thr Glu Val Glu Asn Asp Gly Glu 
            260                 265                 270         


Thr Pro Lys Lys Asp Lys Glu Gly Asn Ile Lys Arg Ser Phe Arg Ala 
        275                 280                 285             


Pro Lys Glu Asp Asp Trp Thr Leu Leu Lys Lys Lys Thr Glu Ala Asp 
    290                 295                 300                 


Ile Glu Asn Ser His Lys Thr Val Gly Cys Tyr Ile Tyr Asp Ser Leu 
305                 310                 315                 320 


Leu Asn Asn Pro Lys Gln Lys Ile Ile Gly Lys Leu Val Arg Thr Val 
                325                 330                 335     


Glu Arg Lys Phe Tyr Lys Glu Glu Leu Thr Gln Ile Leu Lys Lys Gln 
            340                 345                 350         


Val Glu Leu Ile Pro Glu Leu Arg Asp Asp Asn Leu Tyr Lys Gln Cys 
        355                 360                 365             


Ile Glu Glu Leu Tyr Pro Ile Asn Glu Ala His Arg Asn Thr Ile Ala 
    370                 375                 380                 


Lys Thr Asp Phe Ala Asn Leu Phe Ile Asn Asp Ile Leu Phe Tyr Gln 
385                 390                 395                 400 


Arg Pro Leu Lys Ser Lys Lys Ser Gln Ile Asp Asn Cys Pro Tyr Glu 
                405                 410                 415     


Glu Arg Ile Phe Ile Asp Ser Lys Thr Gly Glu Lys Lys Lys Val Pro 
            420                 425                 430         


Val Lys Cys Ile Ala Lys Ser Asn Pro Leu Phe Gln Glu Phe Arg Leu 
        435                 440                 445             


Trp Gln Phe Ile Gln Asn Leu Arg Ile Tyr Gln Arg Glu Lys Glu Ile 
    450                 455                 460                 


Asp Gly Lys Leu Leu Thr Asp Ile Asp Ile Thr Ser Glu Cys Leu Lys 
465                 470                 475                 480 


Ser Glu Glu Asp Tyr Val Arg Leu Phe Asp Trp Leu Asn Asp Arg Glu 
                485                 490                 495     


Thr Ile Glu Gln Glu Asp Leu Leu Lys His Leu Phe Asn Thr Lys Lys 
            500                 505                 510         


Ser Lys Asn Lys Glu Asn Pro Tyr Arg Trp Asn Tyr Val Glu Asp Lys 
        515                 520                 525             


Val Tyr Pro Cys Asn Glu Thr Arg Ala Thr Ile Leu Lys Gly Phe Ser 
    530                 535                 540                 


Lys Cys Gly Ile Asn Ala Ser Val Leu Ser Pro Glu Leu Glu Met Ala 
545                 550                 555                 560 


Leu Trp His Ile Leu Tyr Ser Val Glu Asp Lys Lys Glu Ile Glu Thr 
                565                 570                 575     


Ala Leu Thr His Phe Ala Gln Lys Gln Gly Trp Asn Asp Asp Phe Ala 
            580                 585                 590         


Lys Val Phe Ser Lys Ala Lys Pro Phe Lys Lys Asp Tyr Gly Ser Tyr 
        595                 600                 605             


Ser Glu Lys Ala Ile Lys Lys Leu Leu Ser Leu Met Arg Met Gly Lys 
    610                 615                 620                 


Tyr Trp Asn Gln Asp Asn Ile Asp Lys Asn Thr Leu Asp Arg Ile Asp 
625                 630                 635                 640 


Lys Ile Ile Asn Gly Glu Tyr Asp Glu Lys Ile Ser Asn Arg Val Arg 
                645                 650                 655     


Asp Asn Ala Ile Asn Leu Lys Asp Ile Ser Asp Phe Arg Gly Leu Pro 
            660                 665                 670         


Val Trp Leu Ala Cys Tyr Ile Val Tyr Asp Arg His Ser Glu Ala Lys 
        675                 680                 685             


Asp Cys Thr Lys Trp Asn Ser Pro Glu Glu Ile Asp Ser Tyr Leu Lys 
    690                 695                 700                 


Lys Phe Lys Gln His Ser Leu Arg Asn Pro Ile Val Glu Gln Val Val 
705                 710                 715                 720 


Thr Glu Thr Leu Arg Thr Val Arg Asp Ile Trp Ile Gln Glu Glu Gln 
                725                 730                 735     


Ile Asp Glu Ile His Leu Glu Leu Gly Arg Asp Leu Lys Asn Pro Ala 
            740                 745                 750         


Asp Lys Arg Lys Lys Met Ser Glu Asn Ile Leu Lys Asn Glu Asn Thr 
        755                 760                 765             


Asn Leu Arg Ile Lys Ala Met Leu Met Glu Phe Met Asn Pro Ser Met 
    770                 775                 780                 


Gly Ile Glu Asn Val Arg Pro Tyr Ser Pro Ser Gln Gln Asp Ile Leu 
785                 790                 795                 800 


Arg Ile Tyr Glu Glu Asn Ala Leu Asp Asn Leu Thr Lys Asp Asp Lys 
                805                 810                 815     


Asp Phe Asp Phe Ile Ser Lys Ile Ser Lys Gln Ala Gln Pro Ser Lys 
            820                 825                 830         


Thr Asp Ile Ile Arg Tyr Lys Cys Trp Leu Glu Gln Lys Tyr Arg Ser 
        835                 840                 845             


Pro Tyr Thr Gly Lys Thr Ile Ser Leu Ser Lys Leu Phe Thr Pro Ala 
    850                 855                 860                 


Tyr Glu Ile Glu His Val Ile Pro Gln Ser Leu Tyr Phe Asp Asp Ser 
865                 870                 875                 880 


Phe Ser Asn Lys Val Ile Cys Glu Ala Glu Val Asn Lys Leu Lys Asp 
                885                 890                 895     


Arg Gln Leu Gly Tyr Lys Phe Ile Ala Glu His His Gly Glu Lys Val 
            900                 905                 910         


Gln Leu Ser Gln Gly Glu Val Val Glu Ile Leu Ser Val Asp Ala Tyr 
        915                 920                 925             


Glu Lys Phe Val Lys Glu Asn Tyr Ala Asn Asn Arg Ile Lys Met Lys 
    930                 935                 940                 


Lys Leu Leu Met Glu Ser Ile Pro Asp Glu Phe Ile Glu Arg Gln Leu 
945                 950                 955                 960 


Asn Asp Ser Arg Tyr Ile Ser Lys Val Val Lys Gly Leu Leu Ser Asn 
                965                 970                 975     


Ile Val Arg Glu Lys Ile Asp Asp Glu Asn Tyr Glu Pro Glu Ala Val 
            980                 985                 990         


Ser Lys Asn Leu Ile Ser Cys Asn  Gly Ala Ile Thr Asp  Arg Leu Lys 
        995                 1000                 1005             


Lys Asp  Trp Gly Met Asn Asp  Val Trp Asn Ser Ile  Ile Leu Pro 
    1010                 1015                 1020             


Arg Phe  Ile Arg Met Asn Gln  Ile Thr Gly Lys Asp  Cys Phe Thr 
    1025                 1030                 1035             


Thr Thr  Asn Ala Glu Gly His  Leu Ile Pro Gln Met  Pro Leu Glu 
    1040                 1045                 1050             


Leu Gln  Lys Gly Phe Asn Lys  Lys Arg Ile Asp His  Arg His His 
    1055                 1060                 1065             


Ala Met  Asp Ala Ile Val Ile  Ala Cys Thr Thr Arg  Asp His Val 
    1070                 1075                 1080             


Asn Leu  Leu Asn Asn Glu Ala  Ala His Ser Lys Phe  Asn Ala Thr 
    1085                 1090                 1095             


Arg Tyr  Gln Leu Gln Arg Lys  Leu Arg Arg Phe Glu  Lys Ala Val 
    1100                 1105                 1110             


Ile Asp  Gly Lys Glu Arg Glu  Val Ala Lys Glu Phe  Leu Lys Pro 
    1115                 1120                 1125             


Trp Asp  Ser Phe Ser Ser Asp  Ser Lys Asn Ile Leu  Glu Asn Ile 
    1130                 1135                 1140             


Ile Val  Ser Phe Lys Gln Asn  Gln Arg Val Ile Asn  Lys Thr Thr 
    1145                 1150                 1155             


Asn Ala  Phe Leu His Phe Asp  Glu Asn Gly Lys Lys  Thr Phe Ile 
    1160                 1165                 1170             


Lys Gln  Gly Lys Gly Asp Ser  Trp Ala Ile Arg Lys  Ser Met His 
    1175                 1180                 1185             


Lys Asp  Thr Val Phe Gly Glu  Ile Asn Leu Arg Lys  Val Arg Ser 
    1190                 1195                 1200             


Val Ser  Leu Asn Glu Ala Ile  Lys Val Pro Glu Arg  Val Leu Asn 
    1205                 1210                 1215             


Lys Lys  Ile Lys Glu Lys Ile  Leu Glu Leu Lys Asn  Asn Lys Ile 
    1220                 1225                 1230             


Asp Ala  Lys Asn Ile Lys Lys  Tyr Ile Glu Glu Asn  His Thr Gly 
    1235                 1240                 1245             


Gly Tyr  Gly Ile Asp Ser Ser  Lys Ile Asp Val Phe  Tyr Phe Thr 
    1250                 1255                 1260             


Lys Glu  Thr Lys Glu Arg Phe  Phe Ala Thr Arg Lys  Thr Leu Asp 
    1265                 1270                 1275             


Thr Ser  Phe Asn Gln Ala Lys  Ile Lys Asp Ser Ile  Ala Asp Ser 
    1280                 1285                 1290             


Gly Ile  Gln Lys Ile Leu Leu  Ala His Leu Lys Ser  Lys Asn Gly 
    1295                 1300                 1305             


Asp Ala  Glu Gln Ala Phe Ser  Pro Asp Gly Ile Asp  Glu Met Asn 
    1310                 1315                 1320             


Lys Asn  Ile Val Glu Leu Asn  Asn Gly Lys Phe His  Gln Pro Ile 
    1325                 1330                 1335             


Leu Lys  Val Arg Val Tyr Glu  Lys Ala Asp Lys Phe  Ala Val Gly 
    1340                 1345                 1350             


Gln Lys  Gly Asn Lys Lys Val  Lys Phe Val Glu Ala  Ala Lys Gly 
    1355                 1360                 1365             


Thr Asn  Leu Phe Phe Ala Ile  Phe Glu Lys Asp Gly  Lys Arg Ser 
    1370                 1375                 1380             


Tyr Leu  Thr Ile Pro Leu Asn  Val Met Ile Asp Cys  Gln Lys Gln 
    1385                 1390                 1395             


Tyr Gly  Asn Gln Trp Lys Asn  Asn Ile Glu Ala Tyr  Leu Lys Glu 
    1400                 1405                 1410             


Lys Glu  Leu Val Glu Lys Asp  Val Lys Leu Gln Phe  Ile Leu Ser 
    1415                 1420                 1425             


Pro Asn  Asp Leu Val Tyr Leu  Pro Thr Glu Gly Ser  Ile Asp Lys 
    1430                 1435                 1440             


Lys Arg  Ile Tyr Lys Val Val  Ser Phe Thr Asn Asn  Arg Leu Tyr 
    1445                 1450                 1455             


Ala Ile  Pro Tyr Ala Ile Ala  Lys Ser Ile Val Asp  Lys Asn Glu 
    1460                 1465                 1470             


Phe Thr  Gln Leu Asn Lys Ile  Glu Phe Thr Asp Asn  Lys Glu Ser 
    1475                 1480                 1485             


Ile Lys  Asp Ala Cys Val Pro  Val Ile Ile Asp Arg  Leu Gly Asn 
    1490                 1495                 1500             


Val Ile  Glu Phe Asn Gly Lys  Arg Leu 
    1505                 1510         


<210>  741
<211>  1436
<212>  PRT
<213>  Bacteroides fragilis NCTC 9343

<400>  741

Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asn Glu Ala Glu Asn Lys Asp Glu Arg Ser Ser Ile Val 
            20                  25                  30          


Lys Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Leu Thr Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Ser Ile Thr Thr Asn Ala Asp Arg Thr Leu Lys 
    50                  55                  60                  


Arg Gly Met Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Glu Thr 
65                  70                  75                  80  


Leu Thr Glu Val Leu Lys Glu His Lys Leu Ile Thr Glu Asp Thr Ile 
                85                  90                  95      


Leu Ser Glu Asn Gly Asn Arg Thr Thr Phe Glu Thr Tyr Arg Leu Arg 
            100                 105                 110         


Ala Lys Ala Val Thr Glu Glu Ile Ser Leu Glu Glu Phe Ala Arg Val 
        115                 120                 125             


Leu Leu Met Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 
    130                 135                 140                 


Lys Gly Val Glu Glu Gly Thr Leu Ile Asp Gly Met Asp Ile Ala Arg 
145                 150                 155                 160 


Glu Leu Tyr Asn Asn Asn Leu Thr Pro Gly Glu Leu Cys Leu Gln Leu 
                165                 170                 175     


Leu Asp Ala Gly Lys Lys Phe Leu Pro Asp Phe Tyr Arg Ser Asp Leu 
            180                 185                 190         


Gln Asn Glu Leu Asp Arg Ile Trp Glu Lys Gln Lys Glu Tyr Tyr Pro 
        195                 200                 205             


Glu Ile Leu Thr Asp Val Leu Lys Glu Glu Leu Arg Gly Lys Lys Arg 
    210                 215                 220                 


Asp Ala Val Trp Ala Ile Cys Ala Lys Tyr Phe Val Trp Lys Glu Asn 
225                 230                 235                 240 


Tyr Thr Glu Trp Asn Lys Glu Lys Gly Lys Thr Glu Gln Gln Glu Arg 
                245                 250                 255     


Glu His Lys Leu Glu Gly Ile Tyr Ser Lys Arg Lys Arg Asp Glu Ala 
            260                 265                 270         


Lys Arg Glu Asn Leu Gln Trp Arg Val Asn Gly Leu Lys Glu Lys Leu 
        275                 280                 285             


Ser Leu Glu Gln Leu Val Ile Val Phe Gln Glu Met Asn Thr Gln Ile 
    290                 295                 300                 


Asn Asn Ser Ser Gly Tyr Leu Gly Ala Ile Ser Asp Arg Ser Lys Glu 
305                 310                 315                 320 


Leu Tyr Phe Asn Lys Gln Thr Val Gly Gln Tyr Gln Met Glu Met Leu 
                325                 330                 335     


Asp Lys Asn Pro Asn Ala Ser Leu Arg Asn Met Val Phe Tyr Arg Gln 
            340                 345                 350         


Asp Tyr Leu Asp Glu Phe Asn Met Leu Trp Glu Lys Gln Ala Val Tyr 
        355                 360                 365             


His Lys Glu Leu Thr Glu Glu Leu Lys Lys Glu Ile Arg Asp Ile Ile 
    370                 375                 380                 


Ile Phe Tyr Gln Arg Arg Leu Lys Ser Gln Lys Gly Leu Ile Gly Phe 
385                 390                 395                 400 


Cys Glu Phe Glu Ser Arg Gln Ile Glu Val Asp Ile Asp Gly Lys Lys 
                405                 410                 415     


Lys Ile Lys Thr Val Gly Asn Arg Val Ile Ser Arg Ser Ser Pro Leu 
            420                 425                 430         


Phe Gln Glu Phe Lys Ile Trp Gln Ile Leu Asn Asn Ile Glu Val Thr 
        435                 440                 445             


Val Val Gly Lys Lys Arg Lys Arg Arg Lys Leu Lys Glu Asn Tyr Ser 
    450                 455                 460                 


Ala Leu Phe Glu Glu Leu Asn Asp Ala Glu Gln Leu Glu Leu Asn Gly 
465                 470                 475                 480 


Ser Arg Arg Leu Cys Gln Glu Glu Lys Glu Leu Leu Ala Gln Glu Leu 
                485                 490                 495     


Phe Ile Arg Asp Lys Met Thr Lys Ser Glu Val Leu Lys Leu Leu Phe 
            500                 505                 510         


Asp Asn Pro Gln Glu Leu Asp Leu Asn Phe Lys Thr Ile Asp Gly Asn 
        515                 520                 525             


Lys Thr Gly Tyr Ala Leu Phe Gln Ala Tyr Ser Lys Met Ile Glu Met 
    530                 535                 540                 


Ser Gly His Glu Pro Val Asp Phe Lys Lys Pro Val Glu Lys Val Val 
545                 550                 555                 560 


Glu Tyr Ile Lys Ala Val Phe Asp Leu Leu Asn Trp Asn Thr Asp Ile 
                565                 570                 575     


Leu Gly Phe Asn Ser Asn Glu Glu Leu Asp Asn Gln Pro Tyr Tyr Lys 
            580                 585                 590         


Leu Trp His Leu Leu Tyr Ser Phe Glu Gly Asp Asn Thr Pro Thr Gly 
        595                 600                 605             


Asn Gly Arg Leu Ile Gln Lys Met Thr Glu Leu Tyr Gly Phe Glu Lys 
    610                 615                 620                 


Glu Tyr Ala Thr Ile Leu Ala Asn Val Ser Phe Gln Asp Asp Tyr Gly 
625                 630                 635                 640 


Ser Leu Ser Ala Lys Ala Ile His Lys Ile Leu Pro His Leu Lys Glu 
                645                 650                 655     


Gly Asn Arg Tyr Asp Val Ala Cys Val Tyr Ala Gly Tyr Arg His Ser 
            660                 665                 670         


Glu Ser Ser Leu Thr Arg Glu Glu Ile Ala Asn Lys Val Leu Lys Asp 
        675                 680                 685             


Arg Leu Met Leu Leu Pro Lys Asn Ser Leu His Asn Pro Val Val Glu 
    690                 695                 700                 


Lys Ile Leu Asn Gln Met Val Asn Val Ile Asn Val Ile Ile Asp Ile 
705                 710                 715                 720 


Tyr Gly Lys Pro Asp Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Lys 
                725                 730                 735     


Lys Asn Ala Lys Glu Arg Glu Glu Leu Thr Lys Ser Ile Ala Gln Thr 
            740                 745                 750         


Thr Lys Ala His Glu Glu Tyr Lys Thr Leu Leu Gln Thr Glu Phe Gly 
        755                 760                 765             


Leu Thr Asn Val Ser Arg Thr Asp Ile Leu Arg Tyr Lys Leu Tyr Lys 
    770                 775                 780                 


Glu Leu Glu Ser Cys Gly Tyr Lys Thr Leu Tyr Ser Asn Thr Tyr Ile 
785                 790                 795                 800 


Ser Arg Glu Lys Leu Phe Ser Lys Glu Phe Asp Ile Glu His Ile Ile 
                805                 810                 815     


Pro Gln Ala Arg Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Glu 
            820                 825                 830         


Ala Arg Ser Val Asn Ile Glu Lys Gly Asn Lys Thr Ala Tyr Asp Phe 
        835                 840                 845             


Val Lys Glu Lys Phe Gly Glu Ser Gly Ala Asp Asn Ser Leu Glu His 
    850                 855                 860                 


Tyr Leu Asn Asn Ile Glu Asp Leu Phe Lys Ser Gly Lys Ile Ser Lys 
865                 870                 875                 880 


Thr Lys Tyr Asn Lys Leu Lys Met Ala Glu Gln Asp Ile Pro Asp Gly 
                885                 890                 895     


Phe Ile Glu Arg Asp Leu Arg Asn Thr Gln Tyr Ile Ala Lys Lys Ala 
            900                 905                 910         


Leu Ser Met Leu Asn Glu Ile Ser His Arg Val Val Ala Thr Ser Gly 
        915                 920                 925             


Ser Val Thr Asp Lys Leu Arg Glu Asp Trp Gln Leu Ile Asp Val Met 
    930                 935                 940                 


Lys Glu Leu Asn Trp Glu Lys Tyr Lys Ala Leu Gly Leu Val Glu Tyr 
945                 950                 955                 960 


Phe Glu Asp Arg Asp Gly Arg Gln Ile Gly Arg Ile Lys Asp Trp Thr 
                965                 970                 975     


Lys Arg Asn Asp His Arg His His Ala Met Asp Ala Leu Thr Val Ala 
            980                 985                 990         


Phe Thr Lys Asp Val Phe Ile Gln  Tyr Phe Asn Asn Lys  Asn Ala Ser 
        995                 1000                 1005             


Leu Asp  Pro Asn Ala Asn Glu  His Ala Ile Lys Asn  Lys Tyr Phe 
    1010                 1015                 1020             


Gln Asn  Gly Arg Ala Ile Ala  Pro Met Pro Leu Arg  Glu Phe Arg 
    1025                 1030                 1035             


Ala Glu  Ala Lys Lys His Leu  Glu Asn Thr Leu Ile  Ser Ile Lys 
    1040                 1045                 1050             


Ala Lys  Asn Lys Val Ile Thr  Gly Asn Ile Asn Lys  Thr Arg Lys 
    1055                 1060                 1065             


Lys Gly  Gly Val Asn Lys Asn  Met Gln Gln Thr Pro  Arg Gly Gln 
    1070                 1075                 1080             


Leu His  Leu Glu Thr Ile Tyr  Gly Ser Gly Lys Gln  Tyr Leu Thr 
    1085                 1090                 1095             


Lys Glu  Glu Lys Val Asn Ala  Ser Phe Asp Met Arg  Lys Ile Gly 
    1100                 1105                 1110             


Thr Val  Ser Lys Ser Ala Tyr  Arg Asp Ala Leu Leu  Lys Arg Leu 
    1115                 1120                 1125             


Tyr Glu  Asn Asp Asn Asp Pro  Lys Lys Ala Phe Ala  Gly Lys Asn 
    1130                 1135                 1140             


Ser Leu  Asp Lys Gln Pro Ile  Trp Leu Asp Lys Glu  Gln Met Arg 
    1145                 1150                 1155             


Lys Val  Pro Glu Lys Val Lys  Ile Val Thr Leu Glu  Ala Ile Tyr 
    1160                 1165                 1170             


Thr Ile  Arg Lys Glu Ile Ser  Pro Asp Leu Lys Val  Asp Lys Val 
    1175                 1180                 1185             


Ile Asp  Val Gly Val Arg Lys  Ile Leu Ile Asp Arg  Leu Asn Glu 
    1190                 1195                 1200             


Tyr Gly  Asn Asp Ala Lys Lys  Ala Phe Ser Asn Leu  Asp Lys Asn 
    1205                 1210                 1215             


Pro Ile  Trp Leu Asn Lys Glu  Lys Gly Ile Ser Ile  Lys Arg Val 
    1220                 1225                 1230             


Thr Ile  Ser Gly Ile Ser Asn  Ala Gln Ser Leu His  Val Lys Lys 
    1235                 1240                 1245             


Asp Lys  Asp Gly Lys Pro Ile  Leu Asp Glu Asn Gly  Arg Asn Ile 
    1250                 1255                 1260             


Pro Val  Asp Phe Val Asn Thr  Gly Asn Asn His His  Val Ala Val 
    1265                 1270                 1275             


Tyr Tyr  Arg Pro Val Ile Asp  Lys Arg Gly Gln Leu  Val Val Asp 
    1280                 1285                 1290             


Glu Ala  Gly Asn Pro Lys Tyr  Glu Leu Glu Glu Val  Val Val Ser 
    1295                 1300                 1305             


Phe Phe  Glu Ala Val Thr Arg  Ala Asn Leu Gly Leu  Pro Ile Ile 
    1310                 1315                 1320             


Asp Lys  Asp Tyr Lys Thr Thr  Glu Gly Trp Gln Phe  Leu Phe Ser 
    1325                 1330                 1335             


Met Lys  Gln Asn Glu Tyr Phe  Val Phe Pro Asn Glu  Lys Thr Gly 
    1340                 1345                 1350             


Phe Asn  Pro Lys Glu Ile Asp  Leu Leu Asp Val Glu  Asn Tyr Gly 
    1355                 1360                 1365             


Leu Ile  Ser Pro Asn Leu Phe  Arg Val Gln Lys Phe  Ser Leu Lys 
    1370                 1375                 1380             


Asn Tyr  Val Phe Arg His His  Leu Glu Thr Thr Ile  Lys Asp Thr 
    1385                 1390                 1395             


Ser Ser  Ile Leu Arg Gly Ile  Thr Trp Ile Asp Phe  Arg Ser Ser 
    1400                 1405                 1410             


Lys Gly  Leu Asp Thr Ile Val  Lys Val Arg Val Asn  His Ile Gly 
    1415                 1420                 1425             


Gln Ile  Val Ser Val Gly Glu  Tyr 
    1430                 1435     


<210>  742
<211>  1426
<212>  PRT
<213>  Capnocytophaga ochracea DSM 7271

<400>  742

Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Phe 
1               5                   10                  15      


Ala His Ile Val Glu Asp Glu Asn Lys Glu Lys Ser Glu Ile Lys Glu 
            20                  25                  30          


Leu Gly Val Arg Ile Val Ser Leu Thr Thr Asp Glu Gln Ser Asp Phe 
        35                  40                  45              


Glu Lys Gly Lys Ser Ile Thr Thr Asn Ala Asn Arg Thr Leu Lys His 
    50                  55                  60                  


Gly Ala Arg Leu Asn Leu Asp Arg Tyr Gln Gln Arg Arg Lys Tyr Leu 
65                  70                  75                  80  


Ile Asp Leu Leu Gln Lys Ala Asn Leu Ile Thr Pro Ser Ser Ile Leu 
                85                  90                  95      


Ala Glu Asn Gly Lys Asn Thr Thr His Ser Thr Trp Gln Leu Arg Ala 
            100                 105                 110         


Lys Ala Val Thr Glu Arg Ile Glu Lys Glu Glu Phe Ala Arg Ile Leu 
        115                 120                 125             


Leu Ala Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala Lys 
    130                 135                 140                 


Thr Glu Asp Glu Gly Gln Ala Ile Asp Gly Met Ala Ile Ala Lys Arg 
145                 150                 155                 160 


Leu Tyr Asp Glu Asn Leu Thr Pro Gly Gln Leu Ser Leu Gln Leu Leu 
                165                 170                 175     


Gln Gln Asn Lys Lys Leu Leu Pro Asp Phe Tyr Arg Ser Asp Leu Gln 
            180                 185                 190         


Lys Glu Phe Asp Leu Val Trp Asn Phe Gln Lys Gln Phe Tyr Pro Asp 
        195                 200                 205             


Ile Leu Thr Asp Ile Phe Tyr Lys Glu Leu Gln Gly Lys Gly Lys Asp 
    210                 215                 220                 


Ala Thr Ser Lys Ala Phe Ser Lys Arg Tyr His Phe Asp Thr Thr Glu 
225                 230                 235                 240 


Asn Lys Gly Ser Lys Glu Ser Val Arg Leu Gln Ala Tyr Gln Trp Arg 
                245                 250                 255     


Ala Glu Ala Ile Ser Lys Gln Leu Ser Lys Glu Glu Val Ala Tyr Val 
            260                 265                 270         


Leu Thr Glu Ile Asn Asn Asn Leu Asn Asn Ala Ser Gly Tyr Leu Gly 
        275                 280                 285             


Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Arg Gln Thr Val 
    290                 295                 300                 


Gly Gln Tyr Leu Tyr Ala Lys Leu Gln Glu Asn Arg His Asn Ser Leu 
305                 310                 315                 320 


Lys Asn Lys Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu Arg 
                325                 330                 335     


Ile Trp Glu Thr Gln Ala Ser Phe His Lys Glu Leu Thr Asp Glu Leu 
            340                 345                 350         


Lys Lys Gln Ile Arg Asp Val Val Ile Phe Tyr Gln Arg Lys Pro Lys 
        355                 360                 365             


Ser Gln Lys Gly Leu Ile Ser Phe Cys Glu Phe Glu Ser Lys Glu Ile 
    370                 375                 380                 


Glu Ile Glu Lys Asp Gly Lys Thr Ile Thr Lys Asn Ile Gly Ala Arg 
385                 390                 395                 400 


Val Val Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Lys Ile Trp Gln 
                405                 410                 415     


Ile Leu Asn Asn Val Ile Cys Lys Arg Lys Gly Ile Arg Lys Lys Lys 
            420                 425                 430         


Ile Ser Ala Lys Thr Thr Gln Leu Asp Leu Leu Asn Glu Ser Ser Gln 
        435                 440                 445             


Thr Ile Phe Ser Leu Asp Met Glu Cys Lys Gln Leu Leu Phe Asp Glu 
    450                 455                 460                 


Leu Asn Leu Lys Gly Asp Leu Lys Ser Asp Lys Val Leu Lys Leu Leu 
465                 470                 475                 480 


Gly Tyr Ser Pro Gln Glu Trp Glu Ile Asn Tyr Asn Gln Leu Glu Gly 
                485                 490                 495     


Asn Arg Thr Gln Lys Ala Leu Tyr Glu Ala Tyr Leu Lys Ile Val Glu 
            500                 505                 510         


Met Glu Ala His Asp Val Lys Asp Ile Leu Gln Ile Lys Ser Ala Lys 
        515                 520                 525             


Asp Asp Trp Ser Leu Asp Glu Ser Pro Leu Ser Ala Ser Glu Ile Arg 
    530                 535                 540                 


Glu Lys Val Lys Ala Ile Phe Gln Thr Leu Gly Ile Cys Thr Lys Ile 
545                 550                 555                 560 


Leu Tyr Phe Asp Pro Leu Leu Pro Val Lys Glu Phe Glu Glu Gln Asp 
                565                 570                 575     


Ser Tyr Gln Leu Trp His Leu Leu Tyr Ser Tyr Glu Ser Asp Asp Ser 
            580                 585                 590         


Thr Ser Gly Asn Glu Thr Leu Tyr Arg Ile Leu Glu Lys Lys Tyr Ala 
        595                 600                 605             


Phe Lys Arg Glu His Ala Arg Ile Leu Ala Asn Val Ala Leu Gln Asp 
    610                 615                 620                 


Asp Tyr Gly Ser Leu Ser Thr Lys Ala Ile Arg Lys Ile Tyr Pro Asn 
625                 630                 635                 640 


Ile Lys Glu Asn Gln Tyr Ser Thr Ala Cys Glu Lys Ala Gly Tyr Lys 
                645                 650                 655     


His Ser Lys Leu Ser Leu Thr Thr Glu Glu Leu Glu Ala Arg Glu Leu 
            660                 665                 670         


Lys Asn Ile Ile Pro Leu Leu Lys Lys Asn Ala Leu Arg Asn Pro Val 
        675                 680                 685             


Val Glu Lys Ile Leu Asn Gln Met Ile Asn Val Val Asn Ala Leu Ile 
    690                 695                 700                 


Glu Lys Asn Ser Glu Arg Asp Ala Glu Gly Lys Ile Thr Lys Tyr Phe 
705                 710                 715                 720 


His Phe Asp Glu Ile Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Asn 
                725                 730                 735     


Ala Gln Lys Arg Tyr Glu Met Thr Gln Asn Ile Asn Lys Ala Lys Leu 
            740                 745                 750         


Glu His Gln Lys Ile Ser Glu Ile Leu Gln Lys Glu Phe Gly Ile Lys 
        755                 760                 765             


Asn Pro Thr Lys Ser Asp Ile Ile Arg Tyr Arg Leu Tyr Gln Glu Leu 
    770                 775                 780                 


Glu His Asn Gly Tyr Lys Glu Leu Tyr Thr Asn Ala Pro Ile Ala Arg 
785                 790                 795                 800 


Asp Met Leu Phe Ser Lys Asn Ile Glu Ile Glu His Ile Val Pro Lys 
                805                 810                 815     


Ala Arg Val Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Thr Phe His 
            820                 825                 830         


Arg Ile Asn Ser Asp Lys Gly Glu Tyr Thr Ala Phe Asp Tyr Ile Thr 
        835                 840                 845             


Ser Leu Asn Ser Glu Glu Glu Leu Asn Gln Tyr Leu Thr Arg Val Glu 
    850                 855                 860                 


Asn Ala Tyr Lys Thr Lys Ser Ile Ser Pro Thr Lys Tyr Lys Asn Leu 
865                 870                 875                 880 


Leu Lys Lys Ala Ser Glu Ile Gly Asp Asp Phe Ile Asn Arg Asp Leu 
                885                 890                 895     


Arg Asp Thr Gln Tyr Ile Ala Lys Lys Ala Lys Glu Ile Leu Phe Gln 
            900                 905                 910         


Val Thr Lys Asn Val Leu Ser Thr Ser Gly Ser Ile Thr Asp Arg Leu 
        915                 920                 925             


Arg Glu Asp Trp Gly Leu Val Asp Val Met Lys Glu Leu Asn Met Pro 
    930                 935                 940                 


Lys Tyr Gln Ser Leu Gly Leu Thr Glu Val Glu Glu Arg Lys Asp Gly 
945                 950                 955                 960 


Asn Lys Val Thr Val Ile Lys Asn Trp Thr Lys Arg Asn Asp His Arg 
                965                 970                 975     


His His Ala Met Asp Ala Leu Thr Val Ala Phe Thr Lys Pro Ser Tyr 
            980                 985                 990         


Ile Gln Tyr Leu Asn His Leu Asn  Ala Arg Lys Asp Glu  Asn Asn Lys 
        995                 1000                 1005             


Asn Tyr  Ser Val Ile Leu Ala  Ile Glu Glu Lys Glu  Thr Ile Lys 
    1010                 1015                 1020             


Val Pro  Thr Asn Asn Gly Lys  Asn Lys Arg Val Phe  Ile Glu Pro 
    1025                 1030                 1035             


Ile Pro  Asn Phe Arg Gln Val  Ala Lys Lys His Leu  Glu Glu Ile 
    1040                 1045                 1050             


Phe Ile  Ser His Lys Ala Lys  Asn Lys Val Val Thr  Lys Asn Thr 
    1055                 1060                 1065             


Asn Lys  Pro Ala Gly Thr Asp  Lys Gln Gln Ile Thr  Leu Thr Pro 
    1070                 1075                 1080             


Arg Gly  Gln Leu His Lys Glu  Thr Ile Tyr Gly Lys  Tyr Gln Tyr 
    1085                 1090                 1095             


Tyr Ile  Asn Lys Glu Glu Lys  Ile Gly Val Lys Phe  Asp Glu Arg 
    1100                 1105                 1110             


Thr Ile  Ala Lys Val Ser Asn  Pro Val Tyr Arg Glu  Ala Leu Leu 
    1115                 1120                 1125             


Lys Arg  Leu Gln Ala Asn Asp  Asn Asp Pro Lys Lys  Ala Phe Ala 
    1130                 1135                 1140             


Gly Lys  Asn Ala Leu Ser Lys  Asn Pro Ile Tyr Leu  Asp Glu Ser 
    1145                 1150                 1155             


Lys Thr  Lys Thr Leu Pro Glu  Lys Val Asn Leu Thr  Tyr Leu Glu 
    1160                 1165                 1170             


Glu Asp  Phe Ser Ile Arg Lys  Asp Ile Ser Pro Asp  Asn Phe Lys 
    1175                 1180                 1185             


Asp Leu  Lys Ser Ile Glu Lys  Val Ile Asp Gln Gly  Val Lys Arg 
    1190                 1195                 1200             


Ile Leu  Ile Lys Arg Leu Gln  Ala Tyr Asp Asn Asp  Pro Lys Lys 
    1205                 1210                 1215             


Ala Phe  Val Asp Leu Glu Lys  Asn Pro Ile Trp Leu  Asn Lys Glu 
    1220                 1225                 1230             


Lys Gly  Ile Ala Ile Lys Arg  Val Thr Ile Ser Gly  Val Asn Asn 
    1235                 1240                 1245             


Ala Gln  Pro Leu His Ile Gly  Lys Asp His Leu Gly  Lys Thr Thr 
    1250                 1255                 1260             


Leu Asn  Lys Glu Gly Lys Glu  Ile Pro Val Asp Tyr  Val Ser Thr 
    1265                 1270                 1275             


Gly Asn  Asn His His Val Ala  Ile Tyr Arg Asp Lys  Glu Gly Asn 
    1280                 1285                 1290             


Leu Gln  Glu Gln Ile Val Ser  Phe Phe Asp Ala Val  Val Arg Ala 
    1295                 1300                 1305             


Gln Gln  Gly Ile Pro Ile Ile  Asp Lys Thr Tyr Lys  Gln Ala Glu 
    1310                 1315                 1320             


Gly Trp  Gln Phe Leu Phe Thr  Met Lys Gln Asn Glu  Met Phe Val 
    1325                 1330                 1335             


Phe Pro  Asn Ala Thr Thr Gly  Phe Asn Pro Ala Glu  Ile Asp Leu 
    1340                 1345                 1350             


Leu Asp  Pro Lys Asn Lys Lys  Leu Ile Ser Pro Asn  Leu Phe Arg 
    1355                 1360                 1365             


Val Gln  Lys Ile Ala Thr Lys  Asp Tyr Phe Phe Arg  His His Leu 
    1370                 1375                 1380             


Glu Thr  Asn Val Glu Thr Asp  Asn Ile Leu Lys Asn  Val Thr Trp 
    1385                 1390                 1395             


Lys Arg  Glu Gly Leu Ser Gly  Leu Lys Asp Ile Val  Lys Val Arg 
    1400                 1405                 1410             


Ile Asn  His Leu Gly Asp Ile  Val Ser Ile Gly Glu  Tyr 
    1415                 1420                 1425     


<210>  743
<211>  1066
<212>  PRT
<213>  Rhodopseudomonas palustris BisB18

<400>  743

Met Ser Glu Arg Val Val Arg Arg Ile Leu Gly Ile Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Cys Gly Trp Gly Val Val Asp Ile Ser Gly Ala Gly Gly Gly 
            20                  25                  30          


Ile Ile Ala Thr Gly Val Arg Cys Phe Asp Ala Pro Leu Ile Asp Lys 
        35                  40                  45              


Thr Gly Glu Pro Lys Ser Ala Thr Arg Arg Thr Ala Arg Gly Gln Arg 
    50                  55                  60                  


Arg Ile Val Arg Arg Arg Arg Gln Arg Met Asn Gly Val Arg Arg Leu 
65                  70                  75                  80  


Leu Cys Glu Phe Gly Leu Leu Pro Asp Pro Arg Pro Asp Ala Leu Asn 
                85                  90                  95      


Gln Ala Met Arg Arg Ile Ser Thr Ala Ser Ala Ala Ala Gln Val Thr 
            100                 105                 110         


Pro Trp Thr Leu Arg Ala Ala Ala His Gln Arg Leu Leu Ser Asn Glu 
        115                 120                 125             


Glu Leu Ala Val Val Leu Gly His Ile Ala Arg His Arg Gly Phe Arg 
    130                 135                 140                 


Ser Asn Ala Lys Asn Glu Ala Gly Ala Asn Ala Ala Asp Glu Thr Ser 
145                 150                 155                 160 


Lys Met Lys Lys Ala Met Glu Ala Thr Arg Glu Gly Leu Ala Lys Tyr 
                165                 170                 175     


His Ala Phe Gly Asp Met Ile Ala Asn Asp Pro Lys Phe Ala Asn Arg 
            180                 185                 190         


Lys Arg Asn Arg Asp Lys Asp Tyr Ser His Thr Ala Lys Arg Ser Asp 
        195                 200                 205             


Leu Glu Asp Glu Val Arg Ala Ile Leu Arg Ala Gln Leu Arg Phe Gly 
    210                 215                 220                 


Ser Ala Ala Ala Thr Glu Thr Leu Ala Gln Thr Phe Ala Asp Val Ala 
225                 230                 235                 240 


Phe Phe Gln Arg Pro Leu Gln Asp Ser Glu Asp Arg Val Gly Asp Cys 
                245                 250                 255     


Pro Phe Glu Pro Gly Gln Lys Arg Ala Ala Arg Arg Ala Pro Ser Phe 
            260                 265                 270         


Glu Leu Phe Arg Phe Leu Ser Arg Leu Ala Asn Leu Lys Leu Ala Val 
        275                 280                 285             


Gly Arg Ser Pro Glu Arg Arg Leu Thr Ala Glu Glu Ile Ala Leu Ala 
    290                 295                 300                 


Ala Lys Gly Phe Gly Glu Thr Lys Lys Thr Ile Thr Phe Lys Ser Leu 
305                 310                 315                 320 


Arg Glu Ala Leu Asp Leu Asp Pro Asn Ala Arg Phe Ser Gly Ile Gly 
                325                 330                 335     


Lys Asp Lys Glu Ala Ser Leu Asp Val Val Ala Arg Thr Gly Gly Ala 
            340                 345                 350         


Ala Tyr Gly Thr Lys Thr Leu Lys Asp Ala Leu Gly Asp Ala Pro Trp 
        355                 360                 365             


Arg Ser Leu Ser Arg Thr Pro Glu Thr Leu Asp Arg Ile Ala Glu Ile 
    370                 375                 380                 


Leu Ser Phe Arg Glu Asp Ile Thr Ser Ile Arg Asn Gly Leu Glu Asp 
385                 390                 395                 400 


Leu Gly Leu Asp Ser Leu Val Val Glu Ala Leu Met Gln Ala Ala Ala 
                405                 410                 415     


Asn Gly Asp Phe Lys Glu Phe Thr Arg Ala Gly His Ile Ser Ala Arg 
            420                 425                 430         


Ala Ala Arg Asn Ile Ile Pro Gly Leu Arg Glu Gly Leu Val Tyr Ser 
        435                 440                 445             


Glu Ala Cys Ala Arg Val Gly Tyr Asp His Ala Ala Arg Leu Ser Val 
    450                 455                 460                 


Pro Leu Asp Gln Val Gly Ser Pro Val Thr Arg Lys Ala Leu Ser Glu 
465                 470                 475                 480 


Ala Leu Lys Gln Val Arg Ala Val Ala Arg Glu Tyr Gly Pro Ile Asp 
                485                 490                 495     


Tyr Phe His Ile Glu Leu Ala Arg Ser Val Gly Lys Ser Ala Glu Glu 
            500                 505                 510         


Arg Lys Gln Leu Thr Asp Gly Ile Glu Ala Arg Asn Val Glu Lys Ala 
        515                 520                 525             


Lys Arg Arg Lys Gln Ala Glu Glu His Leu Gly Arg Ala Pro Ser Asp 
    530                 535                 540                 


Asp Glu Leu Leu Arg Tyr Glu Leu Ala Lys Glu Gln Asn Phe Lys Cys 
545                 550                 555                 560 


Ile Tyr Ser Gly Asp Ala Ile Asp Pro Ala Gly Val Ala Ala Asn Asp 
                565                 570                 575     


Thr Arg Tyr Gln Val Asp His Ile Leu Pro Trp Ser Arg Phe Gly Asp 
            580                 585                 590         


Asp Ser Tyr Leu Asn Lys Thr Leu Cys Thr Ala Arg Ser Asn Gln Asn 
        595                 600                 605             


Lys Arg Gly Arg Thr Pro Phe Glu Trp Phe Glu Ala Asp Lys Thr Asp 
    610                 615                 620                 


Val Glu Trp Met Glu Tyr Val Ala Arg Val Glu Asn Leu Gln Glu Val 
625                 630                 635                 640 


Lys Gly Arg Lys Lys Arg Asn Tyr Ser Ile Lys Asp Ala Ala Ala Ile 
                645                 650                 655     


Glu Asp Lys Phe Lys Ala Arg Asn Leu Thr Asp Thr Gln Trp Ala Thr 
            660                 665                 670         


Arg Leu Leu Ala Asp Glu Leu Ser Arg Met Phe Pro Pro Arg Glu Cys 
        675                 680                 685             


Glu Arg Ala Ile Cys Gly Arg Ala Asp Gly Gly Asn Asp Gly Leu Thr 
    690                 695                 700                 


Ile Val Glu Glu Arg Arg Val Phe Thr Arg Pro Gly Ala Ile Thr Ser 
705                 710                 715                 720 


Lys Leu Arg Arg Ala Trp Gly Leu Glu Gly Leu Lys Lys Gln Asp Gly 
                725                 730                 735     


Lys Arg Val Glu Asp Asp Arg His His Ala Val Asp Ala Leu Val Leu 
            740                 745                 750         


Ala Ala Thr Thr Glu Ser Leu Leu Gln Arg Leu Thr Val Glu Val Gln 
        755                 760                 765             


Arg Arg Glu Arg Glu Gly Arg Pro Asp Asp Ile Phe His Cys Ala Glu 
    770                 775                 780                 


Pro Trp Arg Gly Phe Arg Ala Asp Val Arg Arg Thr Val Tyr Gly Ser 
785                 790                 795                 800 


Glu Thr Met Pro Gly Ile Phe Val Ser Arg Ala Glu Arg Arg Arg Ala 
                805                 810                 815     


Arg Gly Lys Ala His Asp Ala Thr Ile Lys Gln Ile Arg Glu Ile Glu 
            820                 825                 830         


Gly Glu Arg Leu Val Phe Glu Arg Lys Pro Val Glu Lys Leu Thr Asp 
        835                 840                 845             


Lys Asp Leu Glu Lys Ile Pro Ile Pro Lys Pro Tyr Gly Gln Val Ser 
    850                 855                 860                 


Asp Pro Lys Arg Leu Arg Asp Glu Leu Val Glu Ser Leu Arg Ala Trp 
865                 870                 875                 880 


Ile Ala Ala Gly Lys Pro Lys Asp Arg Pro Pro Leu Ser Pro Lys Gly 
                885                 890                 895     


Asp Val Ile Arg Lys Val Arg Ile Gln Thr Asn Asp Lys Val Ser Val 
            900                 905                 910         


Glu Ile Asn Gly Gly Thr Val Asp Arg Gly Asp Met Ala Arg Val Asp 
        915                 920                 925             


Val Phe Arg Lys Lys Asn Lys Lys Ala Val Trp Glu Tyr Tyr Val Val 
    930                 935                 940                 


Pro Ile Tyr Pro His Gln Ile Val Ala Leu Asn Asp Pro Pro Asp Arg 
945                 950                 955                 960 


Ala Val Ile Ala Tyr Ala Glu Asp Lys Asp Trp Lys Glu Ile Asp Ser 
                965                 970                 975     


Ser Tyr Glu Phe Leu Trp Ser Leu Phe Gly Leu Ser Tyr Val Glu Ile 
            980                 985                 990         


Ser Lys Ala Asn Gly Glu Cys Ile  Asp Gly Tyr Phe Arg  Gly Leu His 
        995                 1000                 1005             


Arg Gly  Thr Gly Ala Ala Ser  Val Cys Lys His Ile  Ser Leu Gly 
    1010                 1015                 1020             


Lys Asp  Ala Thr Val Ser Gly  Ile Gly Leu Lys Thr  Leu Ala Ser 
    1025                 1030                 1035             


Phe Lys  Lys Phe Thr Ile Asp  Arg Leu Gly Arg Lys  Phe Glu Ile 
    1040                 1045                 1050             


Pro Arg  Glu Val Arg Thr Trp  Arg Gly Glu Ala Cys  Thr 
    1055                 1060                 1065     


<210>  744
<211>  1425
<212>  PRT
<213>  Prevotella micans F0438

<400>  744

Met Ile Gln Lys Ile Phe Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly 
1               5                   10                  15      


Ser Ser Val Arg Asn Leu Glu Leu Gly Glu Asn Leu Thr Glu Gln Leu 
            20                  25                  30          


Glu Phe Phe Ser Ser Asp Ile Phe Gly Ser Ser Val Ser Lys Asn Ser 
        35                  40                  45              


Asn Gly Arg Glu Tyr Ser Leu Ala Gly Asn Arg Ser Ala His Arg Arg 
    50                  55                  60                  


Ser Arg Gly Leu Asn Glu Ala Arg Arg Arg Lys Leu Trp Ala Thr Leu 
65                  70                  75                  80  


Asp Leu Leu Ile Glu His Gly Leu Cys Pro Met Ser Pro Asp Ser Leu 
                85                  90                  95      


Met Gln Trp Arg Thr Tyr Asp Lys Gln Lys Gly Leu Tyr Arg Gln Tyr 
            100                 105                 110         


Pro Ile Glu Asp Lys Asp Phe Asn Ala Trp Ile Met Leu Asp Phe Asn 
        115                 120                 125             


Gly Asp Gly Lys Pro Asp Tyr Ser Ser Pro Tyr Gln Leu Arg Arg Glu 
    130                 135                 140                 


Leu Val Val Arg Gln Phe Asp Phe Asp Gln Pro Ile Glu Arg Tyr Lys 
145                 150                 155                 160 


Leu Gly Arg Ala Leu Tyr His Ile Ala Gln His Arg Gly Phe Lys Ser 
                165                 170                 175     


Ser Lys Gly Glu Thr Ile Ala Asp Gln Glu Lys Asn Glu Lys Lys Pro 
            180                 185                 190         


Ile Ala Glu Glu Gly Ala Asp Ile Ala Asn Glu Met Lys Ala Ser Glu 
        195                 200                 205             


Thr Lys Leu Ser Lys Gly Leu Val Ala Tyr Met Gln Glu Asn His Leu 
    210                 215                 220                 


Lys Thr Val Gly Glu Ala Phe Ala Lys Leu Glu Asp Glu Arg Val Arg 
225                 230                 235                 240 


Ile Arg Asn Asn Glu Ser Tyr Arg Ala Ile Arg Ser Gln Tyr Gln Asp 
                245                 250                 255     


Glu Ile Lys Glu Ile Phe Thr Tyr Gln Lys Lys Leu Ser Val Glu Ser 
            260                 265                 270         


Glu Leu Tyr Glu Arg Leu Thr Ser Glu Lys Lys Gly Val Gly Thr Ile 
        275                 280                 285             


Phe Tyr Lys Arg Pro Leu Arg Ser Gln Arg Gly Asn Val Gly Lys Cys 
    290                 295                 300                 


Thr Leu Glu Arg Asn Lys Pro Arg Cys Pro Ile Gly Arg Pro Glu Phe 
305                 310                 315                 320 


Glu Glu Phe Arg Ala Trp Thr Leu Ile Asn Asn Ile Lys Ile Arg Glu 
                325                 330                 335     


Thr Ala Gly Glu Pro Tyr Lys Gln Leu Pro Ile Lys Leu Arg Gln Glu 
            340                 345                 350         


Leu Leu Lys Asp Cys Phe Leu Ser Lys Val Lys Ala Asp Phe Lys Phe 
        355                 360                 365             


Glu Asp Ile Arg Lys Tyr Ile Glu Lys Arg Leu Gly Leu Ser Phe Ser 
    370                 375                 380                 


Asn Asp Asp Lys Thr Ile Asn Tyr Lys Asp Ser Val Ser Ile Ala Ala 
385                 390                 395                 400 


Cys Pro Val Thr Val Arg Met Lys Lys Leu Leu Gly Glu Asn Trp Ala 
                405                 410                 415     


Asn Cys Arg Ile Asp Gly Glu Lys Arg Arg Gln Ala His Gly Lys Asn 
            420                 425                 430         


Asn Asn Asn Glu His Ile Val Ser Tyr Thr Glu Glu Asp Ile Trp His 
        435                 440                 445             


Val Cys Tyr Asn Ala Glu Asp Pro Glu Glu Val Ser Asn Phe Ala Arg 
    450                 455                 460                 


Lys Ala Leu His Trp Asp Glu Asn Lys Ile Lys Glu Leu Val Arg Leu 
465                 470                 475                 480 


Trp Thr Ser Ile Pro Gln Gly Tyr Ala Met Leu Ser Leu Lys Ala Ile 
                485                 490                 495     


Arg Asn Ile Asn Arg Met Leu Leu Leu Gly Leu Lys Tyr Ser Asp Ala 
            500                 505                 510         


Val Leu Leu Ala Lys Leu Pro Asp Ile Val Pro Val Ser Asp Glu Asp 
        515                 520                 525             


Ile Leu Ala Ile Thr Lys Glu Phe Leu Gln Leu Glu Asp Lys Leu Asn 
    530                 535                 540                 


Gln Glu Lys Gln Ile Asn Asn Ile Val Asn Ser Leu Ile Ala Asn Tyr 
545                 550                 555                 560 


Lys Ser Lys Leu Glu Glu Asn Arg Phe Ala Asp His Asn Tyr Gln Tyr 
                565                 570                 575     


Gln Leu Gly Glu Gly Asp Asp Glu Asp Ile Asn Thr Gln Ile Lys Ser 
            580                 585                 590         


His Ile Gly Ala Lys Leu Trp Val Gln Ile Gly Ala Asp Glu Gln Thr 
        595                 600                 605             


Lys Ile Phe Gln Ala Val Arg Ser Lys Tyr Gln Asp Phe Phe Lys Ser 
    610                 615                 620                 


Tyr Lys Arg Lys Phe Val Glu Ser Pro Lys Leu Gly Glu Leu Leu Val 
625                 630                 635                 640 


Ala Phe Leu Thr Glu Lys Phe Pro Asn Val Lys Ser Lys Gln Trp Glu 
                645                 650                 655     


Arg Leu Tyr His Pro Ser Gln Ile Ala Ile Tyr Arg Pro Ile Pro Val 
            660                 665                 670         


Asp Asn Asp Arg Ser Lys Leu Arg Leu Gly Asn Pro Asn Ile Gly Ala 
        675                 680                 685             


Ile Lys Asn Pro Thr Val Met Arg Val Leu Asn Thr Leu Arg Arg Arg 
    690                 695                 700                 


Val Asn Gln Leu Leu Asp Asp Gly Val Ile Ser Pro Asp Glu Thr Arg 
705                 710                 715                 720 


Val Val Val Glu Thr Ala Arg Glu Leu Asn Asp Ala Asn Thr Lys Trp 
                725                 730                 735     


Ala Leu Asp Arg Tyr Asn Arg Ile Arg Arg Asp Glu Asn Glu Lys Ile 
            740                 745                 750         


Arg Lys Ile Leu Lys Glu Leu Asn Pro Thr Thr Asn Ser Ile Ser Glu 
        755                 760                 765             


Gln Asp Ile Asp Lys Ala Arg Tyr Ile Phe Glu Gln Cys Glu Thr Asp 
    770                 775                 780                 


Phe Tyr Thr Asp Gly Lys Val Pro Tyr Tyr Asn Lys Asp Ile Lys Lys 
785                 790                 795                 800 


Tyr Lys Leu Trp Leu Glu Gln Gly Gly Gln Cys Leu Tyr Thr Gly Gln 
                805                 810                 815     


Thr Ile Asn Leu Thr Asn Leu Phe Asn Pro Asn Ala Phe Asp Met Glu 
            820                 825                 830         


His Thr Ile Pro Lys Ser Ile Ser Phe Asp Asn Ser Asp Gln Asn Leu 
        835                 840                 845             


Thr Leu Cys Glu Ser Tyr Tyr Asn Arg Phe Ile Lys Lys Asn Asn Ile 
    850                 855                 860                 


Pro Thr Asp Met Pro Asn Tyr Asp Lys Asp Val Thr Ile Asn Gly Lys 
865                 870                 875                 880 


Glu Tyr Thr Ala Ile Lys Pro Arg Leu Gln Arg Trp Lys Glu Arg Val 
                885                 890                 895     


Asp Arg Leu Ser Arg Asn Val Asp Phe Trp Lys Gly Gln Ala Arg Arg 
            900                 905                 910         


Ala Gln Asp Lys Asp Arg Lys Asp Glu Cys Ile Arg Glu Lys His Leu 
        915                 920                 925             


Trp Asp Met Glu Leu Ala Tyr Trp Lys Gly Lys Leu Glu Arg Phe Thr 
    930                 935                 940                 


Met Thr Asp Val Thr Asp Gly Phe Lys Asn Ser Gln Leu Val Asp Thr 
945                 950                 955                 960 


Arg Val Ile Thr Arg His Ala Val Leu Tyr Leu Lys Ser Ile Phe Asn 
                965                 970                 975     


His Val Glu Val Gln Arg Gly Glu Thr Thr Ala Glu Phe Arg Lys Ile 
            980                 985                 990         


Leu Gly Leu Gln Ser Ile Asp Glu  Lys Lys Asp Arg Ser  Leu His Ser 
        995                 1000                 1005             


His His  Ala Ile Asp Ala Thr  Met Leu Thr Val Ile  Pro Ser Ala 
    1010                 1015                 1020             


Ala Lys  Arg Asp Arg Met Leu  Glu Leu Phe Tyr Lys  Ile Glu Glu 
    1025                 1030                 1035             


Thr Lys  Lys Ala Leu Lys Asn  Tyr Asn Asp Asn Asn  Lys Thr Gly 
    1040                 1045                 1050             


Leu Asn  Leu Glu Leu Lys Gly  Leu Glu Glu Lys Leu  Asp Lys Glu 
    1055                 1060                 1065             


Lys Lys  Asp Cys Arg Val Gly  Arg Arg Val Asn Asp  Leu Asp Arg 
    1070                 1075                 1080             


Phe Ile  Asn Glu Asn Ile Ile  Val Ser His His Thr  Lys Asp Gln 
    1085                 1090                 1095             


Ala Leu  Thr Pro Ala His Arg  Arg Leu Arg Lys Arg  Gly Lys Ile 
    1100                 1105                 1110             


Val Gly  Gly Lys Glu His Pro  Arg Trp Gln Thr Gly  Asp Ser Leu 
    1115                 1120                 1125             


Arg Gly  Glu Ile His Lys Ala  Ser Tyr Tyr Gly Ala  Ile Thr Gln 
    1130                 1135                 1140             


Phe Ala  Lys Asp Ala Asn Gly  Lys Val Leu Met Lys  Asp Gly Gln 
    1145                 1150                 1155             


Ala Gln  Ile Asp Pro Thr Ile  Tyr Tyr Val Ile Arg  Arg Glu Leu 
    1160                 1165                 1170             


Lys Tyr  Lys Arg Ser Thr Gln  Asp Ser Gly Phe Thr  Asn Trp Glu 
    1175                 1180                 1185             


Asp Leu  Glu Lys Val Ile Val  Asp Thr Asp Leu Phe  Gly Leu Met 
    1190                 1195                 1200             


Lys Gly  Gln Phe Pro Glu Gly  Thr Ser Phe Lys Asp  Ala Cys Glu 
    1205                 1210                 1215             


Gln Gly  Phe Tyr Met Ile Lys  Lys Gly Lys Asn Gly  Glu Gly Asp 
    1220                 1225                 1230             


Val Lys  Thr His Arg Ile Arg  His Val Arg Cys Lys  Ala Val Lys 
    1235                 1240                 1245             


Thr Ala  Leu Arg Ile Lys Glu  Gln Thr Tyr Lys Ser  Ser Lys Asp 
    1250                 1255                 1260             


Tyr Lys  Gln Phe Phe Tyr Ala  Ala Val Gly Asp Leu  Tyr Val Met 
    1265                 1270                 1275             


Cys Tyr  Tyr Thr Asp Gly Lys  Lys Arg Asp Phe Lys  Ile Tyr Ser 
    1280                 1285                 1290             


Leu Tyr  Asp Ile Ser Asn His  Arg Lys Ser Gly Thr  Glu Asp Ile 
    1295                 1300                 1305             


Pro Lys  Phe Ile Thr Asp Lys  Lys Gly Asn His Leu  Pro Leu Asp 
    1310                 1315                 1320             


Tyr Lys  Leu Arg Thr Gly Asp  Met Val Leu Leu Tyr  Lys Asp Asn 
    1325                 1330                 1335             


Pro Glu  Glu Leu Lys Asp Leu  Asp Gln Val Asn Leu  Lys Arg Arg 
    1340                 1345                 1350             


Leu Tyr  Lys Val Asn Arg Phe  Glu Ser Glu Gly Leu  Ile Ile Leu 
    1355                 1360                 1365             


Leu Thr  His His Leu Ser Thr  Thr Thr Glu Arg Gly  Cys Ser Ile 
    1370                 1375                 1380             


Gly Lys  Ile Glu Asn Tyr Gln  Asn Leu Pro Thr Ala  Ile Arg Cys 
    1385                 1390                 1395             


Gly Ile  Lys Thr Ile Lys Phe  Leu Ile Met Gly Lys  His Arg Asp 
    1400                 1405                 1410             


Phe Val  Ile Arg Asn Gly Asn  Ile Glu Phe Lys His  
    1415                 1420                 1425 


<210>  745
<211>  1204
<212>  PRT
<213>  Prevotella ruminicola 23

<400>  745

Met Glu Arg Ile Leu Gly Ile Asp Thr Gly Thr Asn Ser Leu Gly Trp 
1               5                   10                  15      


Ala Ile Val Asp Lys Asp Glu Asn Gln Tyr His Leu Val Ala Lys Gly 
            20                  25                  30          


Thr Asn Ile Phe Ser Glu Gly Val Lys Ile Glu Lys Gly Ile Glu Ser 
        35                  40                  45              


Ser Lys Ala Ala Glu Arg Thr Glu His Arg Ser Val Arg Lys His Tyr 
    50                  55                  60                  


Trp Arg Arg Lys Ile Arg Lys Ile Arg Leu Leu Thr Ile Leu Ser Asp 
65                  70                  75                  80  


Asn Asp Leu Cys Pro Arg Leu Lys His Glu Gln Leu Arg Gln Trp Arg 
                85                  90                  95      


Leu Lys Lys Val Tyr Pro Thr Asp Asp Thr Phe Met Glu Trp Gln Arg 
            100                 105                 110         


Thr Glu Asp Lys Ala Gln Val Asn Pro Tyr Lys Phe Arg Tyr Ile Cys 
        115                 120                 125             


Leu Thr Gln Lys Leu Asp Leu Ser Asp Ile Thr Gln Arg Phe Ile Leu 
    130                 135                 140                 


Gly Arg Ala Leu Tyr His Leu Asn Gln Arg Arg Gly Phe Leu Ser Asn 
145                 150                 155                 160 


Arg Lys Glu Ala Thr Lys Glu Ser Glu Gly Thr Val Lys Glu Gly Ile 
                165                 170                 175     


Ser Ser Leu Ser Lys Asp Met Lys Asp Ser Gly Cys Glu Tyr Leu Gly 
            180                 185                 190         


Glu Tyr Phe Tyr Gln Leu Tyr Gln Gln Gly Lys Lys Ile Arg Asn His 
        195                 200                 205             


Tyr Thr Ala Arg Lys Glu His Tyr Leu Lys Glu Phe Lys Ala Ile Cys 
    210                 215                 220                 


Ser Lys Gln Glu Leu Asp Asp Ala Leu Ile Glu Lys Leu Glu Lys Ala 
225                 230                 235                 240 


Ile Phe Asp Gln Arg Pro Leu Lys Ser Gln Lys Gly Gln Val Gly Thr 
                245                 250                 255     


Cys Thr Phe Glu Lys Gly Lys Ser Arg Cys Pro Ser Ser His Pro Leu 
            260                 265                 270         


Tyr Glu Asp Phe Arg Met Tyr Ser Phe Ile Asn Asn Ile Lys Val Gln 
        275                 280                 285             


Val Asp Thr Leu Tyr Asp Lys Gly Glu Arg Ser Leu Thr Asp Glu Glu 
    290                 295                 300                 


Lys Gln Leu Ile Ile Pro Leu Phe Lys Arg Lys Ser Lys Arg Thr Phe 
305                 310                 315                 320 


Pro Phe Glu Asp Ile Ala Lys Lys Ile Ala Gly Lys Asn Asn Tyr Cys 
                325                 330                 335     


Tyr Ile Lys Ser Asn Glu Glu Lys Ala Tyr Lys Phe Asn Tyr Gln Met 
            340                 345                 350         


Asp Thr Gln Val Ser Gly Ser Pro Val Asn Ala Gln Leu Glu Glu Ile 
        355                 360                 365             


Phe Gly Glu Asp Trp Leu Ser Ser Val Cys Glu Val Tyr Thr Leu Ala 
    370                 375                 380                 


Asn Asn Lys Ser Arg Phe Gln Ile Met Asn Asp Val Trp His Val Leu 
385                 390                 395                 400 


Phe Phe Tyr Asp Asp Glu Asp Lys Leu Lys Glu Phe Ala Lys Asp Arg 
                405                 410                 415     


Leu Gln Leu Asp Asp Glu Leu Ala Glu Lys Phe Ser Lys Ile Ser Ile 
            420                 425                 430         


Pro Asn Asp Tyr Ala Ala Leu Ser Leu Lys Ala Ile Arg Lys Ile Met 
        435                 440                 445             


Pro Tyr Leu Arg Asp Tyr Gly Leu Ile Tyr Ser Glu Ala Val Phe Leu 
    450                 455                 460                 


Ala Asn Leu Val Asp Val Leu Pro Gln His Val Trp Gly Ile Lys Glu 
465                 470                 475                 480 


Met Arg Glu Ala Ala Ile Glu Asn Val Ile Asp Val Met His Ser Tyr 
                485                 490                 495     


Asp Lys Asn Asn Ile Asp Gly Ile Thr Leu Glu Gly Cys Val Lys Thr 
            500                 505                 510         


Phe Leu Lys Glu Arg Tyr Gln Val Ser Asp Asp Asn Leu Lys Lys Leu 
        515                 520                 525             


Tyr His Pro Ser Met Leu Asp Pro Tyr Pro Arg Gln Arg Pro Asn Asp 
    530                 535                 540                 


Glu Gly Val Phe Gln Leu Gly Ser Pro Arg Ile Ser Ser Val Lys Asn 
545                 550                 555                 560 


Pro Met Ala Met His Ser Leu Phe Arg Leu Arg Lys Val Val Asn Leu 
                565                 570                 575     


Met Leu Lys Lys Gly Tyr Ile Thr Pro Asp Thr Lys Val His Ile Glu 
            580                 585                 590         


Phe Ser Arg Asp Leu Asn Asp Ala Asn Lys Arg Trp Ala Ile Gln Thr 
        595                 600                 605             


Trp Gln Arg Glu Asn Glu Lys Glu Arg Glu Arg Cys Arg Lys Glu Ile 
    610                 615                 620                 


Glu Lys Tyr Ile Ala Ser Pro Ser Asp Thr Asp Ile Leu Lys Tyr Gln 
625                 630                 635                 640 


Leu Trp Glu Glu Gln Asn His Lys Cys Leu Tyr Thr Gly Asp Glu Ile 
                645                 650                 655     


Arg Ile Thr Asp Phe Leu Gly Asp Asn Pro Lys Tyr Asp Ile Glu His 
            660                 665                 670         


Thr Ile Pro Arg Ser Ala Gly Gly Asp Ser Thr Lys Met Asn Leu Thr 
        675                 680                 685             


Leu Cys Ser Ser Arg Phe Asn Arg Asp Glu Lys Lys Thr Lys Leu Pro 
    690                 695                 700                 


Ala Glu Leu Val Asn His Asp Glu Ile Leu Glu Arg Ile Ser Asn Trp 
705                 710                 715                 720 


Lys Glu Lys Tyr Glu Asp Ile Asp Lys Gln Ile Arg Lys Ile Ser Thr 
                725                 730                 735     


Lys Gly Ala Thr Ser Lys Glu Asp Lys Asp Ser Lys Ile Arg Arg Arg 
            740                 745                 750         


His Tyr Leu Ile Leu Gln Arg Asp Tyr Trp Arg Gly Lys Tyr Gln Arg 
        755                 760                 765             


Phe Thr Met Thr Glu Val Pro Glu Gly Phe Ser Arg Arg Gln Gly Thr 
    770                 775                 780                 


Asp Ile Ser Val Ile Ser Arg Tyr Ala Arg Met Tyr Leu Lys Ser Val 
785                 790                 795                 800 


Phe Lys Gln Val Tyr Ile Val Lys Gly Ile Ala Thr Ser Asp Phe Arg 
                805                 810                 815     


Lys Met Trp Gly Ile Gln Asp Glu Tyr Ala Lys Lys Glu Arg Val Asn 
            820                 825                 830         


His Val His His Cys Ile Asp Ala Ile Thr Ile Ala Cys Ile Gly Lys 
        835                 840                 845             


Ala Glu Tyr Asp Lys Leu Ala Asp Tyr Arg His Gln Tyr Asp Asp Tyr 
    850                 855                 860                 


Leu Phe Gln Gly Lys Thr Lys Pro Thr Phe Asp Lys Pro Trp Pro Ser 
865                 870                 875                 880 


Phe Val Ile Asp Ile Lys His Ile Gln Asp Glu Leu Leu Ile Ala His 
                885                 890                 895     


Tyr Ala Lys Asp Asn Leu Glu Lys Phe Thr Lys Lys Asn Leu Arg Gly 
            900                 905                 910         


Lys Asp Gly Arg Ile Ile Arg Asp Lys Phe Gly Asn Lys Leu Gln Met 
        915                 920                 925             


Lys Gly Asp Thr Ser Arg Asn Ser Leu His Asn Asp Lys Phe Tyr Gly 
    930                 935                 940                 


Ala Ile Asn His Glu Gly Glu Ile Lys Tyr Val Tyr Arg Thr Asn Ile 
945                 950                 955                 960 


Glu Ala Leu Asp Ala Lys Ser Ile Gly Asn Ile Val Asp Pro Thr Val 
                965                 970                 975     


Arg Ser Ile Ile Glu Ser Ala Ile Ala Ile His Gly Ser Leu Lys Ala 
            980                 985                 990         


Ala Ile Asn Lys Gly Ile Trp Met  Asn Glu Glu Lys His  Ile Pro Ile 
        995                 1000                 1005             


Lys Lys  Val Arg Val Phe Arg  Asn Asp Val Lys Lys  Pro Ile Glu 
    1010                 1015                 1020             


Leu Lys  Asp Gln Arg Asp Leu  Ser Asp Lys Asp Tyr  Lys Gln His 
    1025                 1030                 1035             


Tyr Tyr  Val Thr Asn Asp Gly  Asn Tyr Met Met Leu  Ile Phe Ser 
    1040                 1045                 1050             


Lys Leu  Asn Asn Lys Gly Arg  Glu Ile Arg Gln His  Val Val Ile 
    1055                 1060                 1065             


Asn Ser  Leu Glu Ala Thr Glu  Val Ile Lys Ser His  Lys Arg Ser 
    1070                 1075                 1080             


Gln Val  Gly Lys Val Val Trp  Glu Ser Tyr Tyr Ser  Lys Glu Gly 
    1085                 1090                 1095             


Phe Asp  Leu Ile Tyr Lys Leu  Lys Ser Gly Thr Met  Ile Leu Leu 
    1100                 1105                 1110             


Tyr Glu  Asn Asn Arg Asp Glu  Val Trp Asp Leu Asp  Ile Arg Asn 
    1115                 1120                 1125             


Leu Gln  Lys Arg Leu Tyr Ile  Ile Thr Lys Met Lys  Tyr Asp Gly 
    1130                 1135                 1140             


Arg Ile  Tyr Met Met His His  Gln Glu Ala Arg Glu  Lys Lys Asp 
    1145                 1150                 1155             


Leu Glu  Glu Lys Ser Gly Ser  Phe Lys Ile Asn Glu  Asp Tyr Arg 
    1160                 1165                 1170             


Pro Leu  Ile Val Asn Ser Tyr  Asn Gln Phe Asn Ala  Leu Val Gln 
    1175                 1180                 1185             


Asp Leu  Asp Phe Glu Ile Asn  Asp Leu Gly Glu Ile  Arg Arg Leu 
    1190                 1195                 1200             


Ile 
    


<210>  746
<211>  1535
<212>  PRT
<213>  Flavobacterium columnare ATCC 49512

<400>  746

Met Thr Lys Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Ile Arg Asp Thr Glu Asn Glu Gly Ile Asn Gln Ile Leu Asp Lys 
            20                  25                  30          


Gly Ala Arg Ile Phe Ser Glu Gly Val Lys Ser Glu Asn Gly Lys Glu 
        35                  40                  45              


Ile Ser Arg Ala Ala Glu Arg Thr Ala Tyr Arg Ser Ala Arg Lys Ile 
    50                  55                  60                  


Lys Tyr Arg Arg Lys Leu Arg Lys Tyr Glu Thr Leu Lys Val Leu Ser 
65                  70                  75                  80  


Ile Asn Gly Met Cys Pro Leu Ser Val Glu Glu Val Glu Gln Trp Lys 
                85                  90                  95      


Lys Ser Gly Phe Lys Glu Tyr Pro Leu Asn Pro Glu Phe Leu Asp Trp 
            100                 105                 110         


Leu Arg Thr Asn Glu Asp Lys Asn Ile Asn Pro Tyr Leu Phe Arg Asp 
        115                 120                 125             


Lys Ala Ser Lys Gln Lys Val Thr Leu Phe Glu Leu Gly Arg Ala Leu 
    130                 135                 140                 


Tyr His Ile Ala Gln Arg Arg Gly Phe Leu Ser Asn Arg Leu Asp Gln 
145                 150                 155                 160 


Ser Ala Glu Gly Val Phe Glu Glu His Asn Pro Gln Ile Gln Asn Leu 
                165                 170                 175     


Ile Glu Asp Leu Asp Ser Ser Asn Thr Ile Leu Asn Glu Leu Lys Glu 
            180                 185                 190         


Tyr Tyr Ile Asn Leu Gly Ile Ile Asp Glu Thr Glu Lys Ser Gly Phe 
        195                 200                 205             


Lys Lys Asp Leu Asp Glu Gly Glu Lys Lys Leu Lys Ser Leu Tyr Asn 
    210                 215                 220                 


Ser Leu Val Ala Ile Thr Lys Lys Asn Ala Asn Asp Ile Glu Thr Cys 
225                 230                 235                 240 


Lys Gln Glu Leu Ile Ala Arg Leu Asn Lys Lys Glu Asp Leu Gly Lys 
                245                 250                 255     


Val Lys Gly Lys Ile Lys Asp Ile Ser Gln Ala Met Leu Asp Arg Asn 
            260                 265                 270         


Phe Lys Thr Leu Gly Gln Tyr Phe Phe Ser Leu Tyr Asn Lys Glu Arg 
        275                 280                 285             


Ile Arg Asn Gln Tyr Thr Ser Arg Glu Glu His Tyr Leu Glu Glu Phe 
    290                 295                 300                 


Ile Ile Ile Cys Gln Thr Gln Gly Ile Glu Gly Ile Asn Thr Asn Glu 
305                 310                 315                 320 


Lys Leu Pro Glu Lys Lys Phe Thr Gly Leu Ala Lys Asp Leu Tyr Arg 
                325                 330                 335     


Ala Ile Phe Phe Gln Arg Pro Leu Lys Ser Gln Lys Gly Leu Ile Gly 
            340                 345                 350         


Lys Cys Ser Phe Glu Lys Asn Lys Ser Arg Cys Ala Val Ser His Pro 
        355                 360                 365             


Asp Tyr Glu Glu Phe Arg Met Trp Ser Tyr Leu Asn Thr Ile Lys Ile 
    370                 375                 380                 


Gly Thr Gln Ser Glu Lys Thr Leu Arg Phe Leu Thr Leu Glu Glu Lys 
385                 390                 395                 400 


Leu Lys Leu Val Pro Lys Phe Tyr Arg Lys Ser Asp Phe Asn Phe Glu 
                405                 410                 415     


Val Leu Ala Lys Glu Leu Val Glu Lys Gly Ala Ser Phe Gly Tyr Tyr 
            420                 425                 430         


Lys Ser Ser Lys Lys Asn Glu Phe Phe Tyr Trp Phe Asn Tyr Lys Pro 
        435                 440                 445             


Thr Asp Ser Val Ser Ala Cys Val Val Ser Ala Ser Leu Glu Asn Ala 
    450                 455                 460                 


Ile Gly Lys Asp Trp Lys Ile Lys Thr Phe Glu Tyr Gln Thr Arg Asn 
465                 470                 475                 480 


Thr Glu Lys Asn Glu Val Thr Lys Ser Val Asp Tyr Lys Asp Leu Trp 
                485                 490                 495     


His Leu Leu Ser Val Ala Thr Ser Asp Thr Tyr Leu Tyr Asp Phe Ala 
            500                 505                 510         


Ile Glu Lys Leu Lys Leu Glu Pro Lys Asn Ala Lys Ala Phe Ser Lys 
        515                 520                 525             


Thr Lys Leu Lys Lys Asp Phe Ala Ser Leu Ser Leu Ala Ala Ile Ala 
    530                 535                 540                 


Lys Ile Leu Pro Tyr Leu Lys Gln Gly Leu Leu Tyr Ser His Ala Val 
545                 550                 555                 560 


Phe Met Ala Asn Ile Glu Asn Ile Val Asp Ala Asp Ile Trp Lys Asp 
                565                 570                 575     


Glu Glu Gln Gln Lys Phe Ile Gln Ser Lys Ile Val Glu Leu Val Asp 
            580                 585                 590         


Asn Tyr Ile Val Glu Lys Ser Lys Leu Glu Leu Ile Asn Gly Leu Leu 
        595                 600                 605             


Lys Ile Tyr Asn Thr Glu Asp Lys Glu Gly Arg Lys Val Tyr Tyr Ser 
    610                 615                 620                 


Lys Glu Ala Glu Ser Leu Phe Glu Ala Asp Leu Arg Lys Lys Leu Val 
625                 630                 635                 640 


Pro Phe Tyr Lys Ala Asn Ile Ile Ile Glu Glu His Glu Gln Glu Ile 
                645                 650                 655     


Ile Phe Gln Asp Leu Phe Pro Ile Leu Met Asp Gln Leu Lys Lys Gln 
            660                 665                 670         


Glu Phe Ile Lys Ile Gly Arg Leu Asp Lys Gln Ile Glu Ala Phe Leu 
        675                 680                 685             


Glu Gly Glu Asn Glu Glu Gly Gln Ile Phe Cys Asn His Thr Asp Lys 
    690                 695                 700                 


Leu Lys Lys Leu Tyr His Pro Ser Asp Ile Glu Val Phe Lys Lys Lys 
705                 710                 715                 720 


Thr Ile Lys Asp Glu Trp Gly Asn Glu Lys Val Val Leu Gly Ser Pro 
                725                 730                 735     


Leu Thr Thr Ser Ile Lys Asn Pro Met Ala Met Arg Ala Leu His Gln 
            740                 745                 750         


Leu Arg Lys Val Leu Asn Thr Leu Ile Ala Asn Asp Gln Ile Asp Glu 
        755                 760                 765             


Asp Thr Arg Ile His Ile Glu Met Ala Arg Glu Leu Asn Asp Ala Asn 
    770                 775                 780                 


Lys Arg Lys Gly Ile Gln Asp Phe Gln Asn Glu Asn Lys Lys Phe Arg 
785                 790                 795                 800 


Glu Glu Ala Ile Lys Glu Ile Lys Lys Leu Tyr Leu Glu Glu Cys His 
                805                 810                 815     


Lys Asp Val Asn Pro Thr Glu Asp Asp Ile Leu Arg Tyr Gln Leu Trp 
            820                 825                 830         


Leu Glu Gln Gly Lys Cys Glu Ile Tyr Glu Glu Gly Asn Asn Ile Ser 
        835                 840                 845             


Ile Cys Asp Ile Ile Gly Ser Asn Pro Ser Tyr Asp Ile Glu His Thr 
    850                 855                 860                 


Ile Pro Arg Ser Ile Ser Gln Asp Asn Ser Gln Met Asn Lys Thr Leu 
865                 870                 875                 880 


Cys Ser Leu Lys Phe Asn Arg Ser Ile Lys Lys Gln Lys Met Pro Val 
                885                 890                 895     


Glu Leu Ser Asn Tyr Asn Asp Ile Leu Pro Arg Ile Ala His Trp Lys 
            900                 905                 910         


Lys Glu Ala Glu Glu Leu Thr Arg Gln Ile Glu Thr Ile Ser Arg Ser 
        915                 920                 925             


Ile Lys Ser Ala Ala Thr Lys Val Ala Lys Asp Lys Asn Ile Arg Lys 
    930                 935                 940                 


Arg His Tyr Leu Thr Leu Lys Arg Asp Tyr Ile Leu Gly Lys Tyr Glu 
945                 950                 955                 960 


Arg Phe Thr Trp Glu Glu Pro Lys Val Gly Phe Lys Asn Ser Gln Ile 
                965                 970                 975     


Pro Asp Thr Gly Ile Ile Thr Lys Tyr Ala Gln Ala Tyr Leu Lys Ser 
            980                 985                 990         


Tyr Phe Lys Arg Val Glu Ser Val  Lys Gly Gly Ala Val  Ala Glu Phe 
        995                 1000                 1005             


Arg Lys  Leu Trp Gly Ile Gln  Glu Ser Phe Ile Asp  Glu Asn Trp 
    1010                 1015                 1020             


Trp Lys  His Tyr Lys Asp Lys  Asp Arg Asp Lys His  Thr His His 
    1025                 1030                 1035             


Thr Ile  Asp Ala Ile Thr Ile  Ala Cys Met Pro Lys  Asp Lys Tyr 
    1040                 1045                 1050             


Asp Leu  Leu Ala His Ala Trp  Arg Leu Glu Asp Glu  Gln Asp Lys 
    1055                 1060                 1065             


Lys Ala  Ala Lys Val Leu Ile  Glu Gln Ala Lys Pro  Trp Lys Thr 
    1070                 1075                 1080             


Phe Lys  Glu Asp Ile Glu Lys  Ile Glu Thr Glu Ile  Leu Val Ser 
    1085                 1090                 1095             


His Phe  Thr Pro Asp Asn Val  Lys Lys Gln Ser Lys  Ser Ile Ile 
    1100                 1105                 1110             


Lys Asn  Arg Gly Lys Lys Val  Tyr Val Leu Lys Asn  Glu Leu Pro 
    1115                 1120                 1125             


Val Asn  Phe Lys Asn Lys Ile  Glu Gly Lys Asp Tyr  Phe Lys Leu 
    1130                 1135                 1140             


Lys Phe  Asp Ser Lys Ile Leu  Tyr Lys Ile Pro Lys  Lys Lys Glu 
    1145                 1150                 1155             


Lys Gln  Thr Asp Thr Phe Tyr  Glu Glu Leu Pro Lys  Asn Tyr Leu 
    1160                 1165                 1170             


Asn Gly  Val Glu Gly Lys Asp  Tyr Phe Lys Ile Asn  Thr Thr Gly 
    1175                 1180                 1185             


Lys Thr  Phe Tyr Lys Ile Pro  Ile Phe Asn Gln Gly  Asp Thr Ile 
    1190                 1195                 1200             


Arg Gly  Ser Leu His Gln Glu  Thr Thr Tyr Gly Ala  Ile Lys Leu 
    1205                 1210                 1215             


Pro Asp  Ile Asp Ile Glu Thr  Lys Lys Pro Leu His  Thr Asp Lys 
    1220                 1225                 1230             


Gly Gly  Phe Ile Leu Lys Lys  Asp Ile Lys Gly Asn  Glu Ile Val 
    1235                 1240                 1245             


Phe Phe  Val Val Arg Lys Glu  Ile Ser Lys Ile Ser  Glu Asn Asp 
    1250                 1255                 1260             


Val Gln  Asn Ile Val Asp Asn  Val Val Arg Lys Lys  Ile Glu Asn 
    1265                 1270                 1275             


Ala Ile  Ala Asn Ser Leu Ile  Thr Phe Lys Ile Val  Lys Lys Lys 
    1280                 1285                 1290             


Lys Val  Ala Val Ile Lys Glu  Gly Val Thr Ile Trp  Met Arg Glu 
    1295                 1300                 1305             


Pro Asn  Ile Glu Lys Gly Ile  Glu Gly Ile Pro Ile  Lys Lys Val 
    1310                 1315                 1320             


Arg Ile  Ile Thr Asn Ser Val  Lys Asn Pro Ile Glu  Ile Lys Val 
    1325                 1330                 1335             


His Ser  Pro Leu Ser Lys Ser  Arg His Lys His Lys  Gln Lys Val 
    1340                 1345                 1350             


Tyr Gly  Gln Asn Asp Glu Asn  Tyr Ala Met Ala Leu  Tyr Glu Leu 
    1355                 1360                 1365             


Asp Gly  Lys Arg Glu Phe Glu  Leu Ile Asn Asn Phe  Asn Leu Ala 
    1370                 1375                 1380             


Lys Leu  Leu Lys Gln Ser Gln  Ser Tyr Tyr Pro Leu  His Lys Glu 
    1385                 1390                 1395             


Lys Glu  Ile Lys Gly Lys Lys  Ile Leu Val Pro Ile  Glu Lys Arg 
    1400                 1405                 1410             


Asn Asn  Lys Asp Val Ile Leu  Lys Arg Gly Gln Gln  Val Val Phe 
    1415                 1420                 1425             


Tyr Asp  Lys Thr Val Glu Asn  Pro Lys Asp Ile Ser  Glu Ile Ile 
    1430                 1435                 1440             


Asp Phe  Arg Glu Arg Ile Tyr  Ile Ile Glu Gly Leu  Thr Ile Gln 
    1445                 1450                 1455             


Arg Gln  Lys Asp Lys Lys Thr  Ser Lys Val Asn Glu  Tyr Gly Ile 
    1460                 1465                 1470             


Ile Gln  Leu Arg His Phe Lys  Glu Ala Arg Lys Ser  Glu Glu Ile 
    1475                 1480                 1485             


Ser Lys  Asp Asn Phe Lys Pro  Asp Gly Glu Phe Lys  Ile Asn Glu 
    1490                 1495                 1500             


Asn Lys  Pro Thr Arg Lys Met  Asn His Asn Gln Phe  Thr Ala Phe 
    1505                 1510                 1515             


Val Glu  Gly Ile Asp Phe Lys  Val Leu Pro Ser Gly  Lys Phe Gln 
    1520                 1525                 1530             


Lys Ile  
    1535 


<210>  747
<211>  1052
<212>  PRT
<213>  Aminomonas paucivorans DSM 12260

<400>  747

Met Ile Gly Glu His Val Arg Gly Gly Cys Leu Phe Asp Asp His Trp 
1               5                   10                  15      


Thr Pro Asn Trp Gly Ala Phe Arg Leu Pro Asn Thr Val Arg Thr Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Asp Gly Ser Ser Leu Ala Glu Pro Arg 
        35                  40                  45              


Arg Gln Ala Arg Gly Leu Arg Arg Arg Leu Arg Arg Lys Thr Gln Arg 
    50                  55                  60                  


Leu Glu Asp Leu Arg Arg Leu Leu Ala Lys Glu Gly Val Leu Ser Leu 
65                  70                  75                  80  


Ser Asp Leu Glu Thr Leu Phe Arg Glu Thr Pro Ala Lys Asp Pro Tyr 
                85                  90                  95      


Gln Leu Arg Ala Glu Gly Leu Asp Arg Pro Leu Ser Phe Pro Glu Trp 
            100                 105                 110         


Val Arg Val Leu Tyr His Ile Thr Lys His Arg Gly Phe Gln Ser Asn 
        115                 120                 125             


Arg Arg Asn Pro Val Glu Asp Gly Gln Glu Arg Ser Arg Gln Glu Glu 
    130                 135                 140                 


Glu Gly Lys Leu Leu Ser Gly Val Gly Glu Asn Glu Arg Leu Leu Arg 
145                 150                 155                 160 


Glu Gly Gly Tyr Arg Thr Ala Gly Glu Met Leu Ala Arg Asp Pro Lys 
                165                 170                 175     


Phe Gln Asp His Arg Arg Asn Arg Ala Gly Asp Tyr Ser His Thr Leu 
            180                 185                 190         


Ser Arg Ser Leu Leu Leu Glu Glu Ala Arg Arg Leu Phe Gln Ser Gln 
        195                 200                 205             


Arg Thr Leu Gly Asn Pro His Ala Ser Ser Asn Leu Glu Glu Ala Phe 
    210                 215                 220                 


Leu His Leu Val Ala Phe Gln Asn Pro Phe Ala Ser Gly Glu Asp Ile 
225                 230                 235                 240 


Arg Asn Lys Ala Gly His Cys Ser Leu Glu Pro Asp Gln Ile Arg Ala 
                245                 250                 255     


Pro Arg Arg Ser Ala Ser Ala Glu Thr Phe Met Leu Leu Gln Lys Thr 
            260                 265                 270         


Gly Asn Leu Arg Leu Ile His Arg Arg Thr Gly Glu Glu Arg Pro Leu 
        275                 280                 285             


Thr Asp Lys Glu Arg Glu Gln Ile His Leu Leu Ala Trp Lys Gln Glu 
    290                 295                 300                 


Lys Val Thr His Lys Thr Leu Arg Arg His Leu Glu Ile Pro Glu Glu 
305                 310                 315                 320 


Trp Leu Phe Thr Gly Leu Pro Tyr His Arg Ser Gly Asp Lys Ala Glu 
                325                 330                 335     


Glu Lys Leu Phe Val His Leu Ala Gly Ile His Glu Ile Arg Lys Ala 
            340                 345                 350         


Leu Asp Lys Gly Pro Asp Pro Ala Val Trp Asp Thr Leu Arg Ser Arg 
        355                 360                 365             


Arg Asp Leu Leu Asp Ser Ile Ala Asp Thr Leu Thr Phe Tyr Lys Asn 
    370                 375                 380                 


Glu Asp Glu Ile Leu Pro Arg Leu Glu Ser Leu Gly Leu Ser Pro Glu 
385                 390                 395                 400 


Asn Ala Arg Ala Leu Ala Pro Leu Ser Phe Ser Gly Thr Ala His Leu 
                405                 410                 415     


Ser Leu Ser Ala Leu Gly Lys Leu Leu Pro His Leu Glu Glu Gly Lys 
            420                 425                 430         


Ser Tyr Thr Gln Ala Arg Ala Asp Ala Gly Tyr Ala Ala Pro Pro Pro 
        435                 440                 445             


Asp Arg His Pro Lys Leu Pro Pro Leu Glu Glu Ala Asp Trp Arg Asn 
    450                 455                 460                 


Pro Val Val Phe Arg Ala Leu Thr Gln Thr Arg Lys Val Val Asn Ala 
465                 470                 475                 480 


Leu Val Arg Arg Tyr Gly Pro Pro Trp Cys Ile His Leu Glu Thr Ala 
                485                 490                 495     


Arg Glu Leu Ser Gln Pro Ala Lys Val Arg Arg Arg Ile Glu Thr Glu 
            500                 505                 510         


Gln Gln Ala Asn Glu Lys Lys Lys Gln Gln Ala Glu Arg Glu Phe Leu 
        515                 520                 525             


Asp Ile Val Gly Thr Ala Pro Gly Pro Gly Asp Leu Leu Lys Met Arg 
    530                 535                 540                 


Leu Trp Arg Glu Gln Gly Gly Phe Cys Pro Tyr Cys Glu Glu Tyr Leu 
545                 550                 555                 560 


Asn Pro Thr Arg Leu Ala Glu Pro Gly Tyr Ala Glu Met Asp His Ile 
                565                 570                 575     


Leu Pro Tyr Ser Arg Ser Leu Asp Asn Gly Trp His Asn Arg Val Leu 
            580                 585                 590         


Val His Gly Lys Asp Asn Arg Asp Lys Gly Asn Arg Thr Pro Phe Glu 
        595                 600                 605             


Ala Phe Gly Gly Asp Thr Ala Arg Trp Asp Arg Leu Val Ala Trp Val 
    610                 615                 620                 


Gln Ala Ser His Leu Ser Ala Pro Lys Lys Arg Asn Leu Leu Arg Glu 
625                 630                 635                 640 


Asp Phe Gly Glu Glu Ala Glu Arg Glu Leu Lys Asp Arg Asn Leu Thr 
                645                 650                 655     


Asp Thr Arg Phe Ile Thr Lys Thr Ala Ala Thr Leu Leu Arg Asp Arg 
            660                 665                 670         


Leu Thr Phe His Pro Glu Ala Pro Lys Asp Pro Val Met Thr Leu Asn 
        675                 680                 685             


Gly Arg Leu Thr Ala Phe Leu Arg Lys Gln Trp Gly Leu His Lys Asn 
    690                 695                 700                 


Arg Lys Asn Gly Asp Leu His His Ala Leu Asp Ala Ala Val Leu Ala 
705                 710                 715                 720 


Val Ala Ser Arg Ser Phe Val Tyr Arg Leu Ser Ser His Asn Ala Ala 
                725                 730                 735     


Trp Gly Glu Leu Pro Arg Gly Arg Glu Ala Glu Asn Gly Phe Ser Leu 
            740                 745                 750         


Pro Tyr Pro Ala Phe Arg Ser Glu Val Leu Ala Arg Leu Cys Pro Thr 
        755                 760                 765             


Arg Glu Glu Ile Leu Leu Arg Leu Asp Gln Gly Gly Val Gly Tyr Asp 
    770                 775                 780                 


Glu Ala Phe Arg Asn Gly Leu Arg Pro Val Phe Val Ser Arg Ala Pro 
785                 790                 795                 800 


Ser Arg Arg Leu Arg Gly Lys Ala His Met Glu Thr Leu Arg Ser Pro 
                805                 810                 815     


Lys Trp Lys Asp His Pro Glu Gly Pro Arg Thr Ala Ser Arg Ile Pro 
            820                 825                 830         


Leu Lys Asp Leu Asn Leu Glu Lys Leu Glu Arg Met Val Gly Lys Asp 
        835                 840                 845             


Arg Asp Arg Lys Leu Tyr Glu Ala Leu Arg Glu Arg Leu Ala Ala Phe 
    850                 855                 860                 


Gly Gly Asn Gly Lys Lys Ala Phe Val Ala Pro Phe Arg Lys Pro Cys 
865                 870                 875                 880 


Arg Ser Gly Glu Gly Pro Leu Val Arg Ser Leu Arg Ile Phe Asp Ser 
                885                 890                 895     


Gly Tyr Ser Gly Val Glu Leu Arg Asp Gly Gly Glu Val Tyr Ala Val 
            900                 905                 910         


Ala Asp His Glu Ser Met Val Arg Val Asp Val Tyr Ala Lys Lys Asn 
        915                 920                 925             


Arg Phe Tyr Leu Val Pro Val Tyr Val Ala Asp Val Ala Arg Gly Ile 
    930                 935                 940                 


Val Lys Asn Arg Ala Ile Val Ala His Lys Ser Glu Glu Glu Trp Asp 
945                 950                 955                 960 


Leu Val Asp Gly Ser Phe Asp Phe Arg Phe Ser Leu Phe Pro Gly Asp 
                965                 970                 975     


Leu Val Glu Ile Glu Lys Lys Asp Gly Ala Tyr Leu Gly Tyr Tyr Lys 
            980                 985                 990         


Ser Cys His Arg Gly Asp Gly Arg  Leu Leu Leu Asp Arg  His Asp Arg 
        995                 1000                 1005             


Met Pro  Arg Glu Ser Asp Cys  Gly Thr Phe Tyr Val  Ser Thr Arg 
    1010                 1015                 1020             


Lys Asp  Val Leu Ser Met Ser  Lys Tyr Gln Val Asp  Pro Leu Gly 
    1025                 1030                 1035             


Glu Ile  Arg Leu Val Gly Ser  Glu Lys Pro Pro Phe  Val Leu 
    1040                 1045                 1050         


<210>  748
<211>  1173
<212>  PRT
<213>  Rhodospirillum rubrum ATCC 11170

<400>  748

Met Arg Pro Ile Glu Pro Trp Ile Leu Gly Leu Asp Ile Gly Thr Asp 
1               5                   10                  15      


Ser Leu Gly Trp Ala Val Phe Ser Cys Glu Glu Lys Gly Pro Pro Thr 
            20                  25                  30          


Ala Lys Glu Leu Leu Gly Gly Gly Val Arg Leu Phe Asp Ser Gly Arg 
        35                  40                  45              


Asp Ala Lys Asp His Thr Ser Arg Gln Ala Glu Arg Gly Ala Phe Arg 
    50                  55                  60                  


Arg Ala Arg Arg Gln Thr Arg Thr Trp Pro Trp Arg Arg Asp Arg Leu 
65                  70                  75                  80  


Ile Ala Leu Phe Gln Ala Ala Gly Leu Thr Pro Pro Ala Ala Glu Thr 
                85                  90                  95      


Arg Gln Ile Ala Leu Ala Leu Arg Arg Glu Ala Val Ser Arg Pro Leu 
            100                 105                 110         


Ala Pro Asp Ala Leu Trp Ala Ala Leu Leu His Leu Ala His His Arg 
        115                 120                 125             


Gly Phe Arg Ser Asn Arg Ile Asp Lys Arg Glu Arg Ala Ala Ala Lys 
    130                 135                 140                 


Ala Leu Ala Lys Ala Lys Pro Ala Lys Ala Thr Ala Lys Ala Thr Ala 
145                 150                 155                 160 


Pro Ala Lys Glu Ala Asp Asp Glu Ala Gly Phe Trp Glu Gly Ala Glu 
                165                 170                 175     


Ala Ala Leu Arg Gln Arg Met Ala Ala Ser Gly Ala Pro Thr Val Gly 
            180                 185                 190         


Ala Leu Leu Ala Asp Asp Leu Asp Arg Gly Gln Pro Val Arg Met Arg 
        195                 200                 205             


Tyr Asn Gln Ser Asp Arg Asp Gly Val Val Ala Pro Thr Arg Ala Leu 
    210                 215                 220                 


Ile Ala Glu Glu Leu Ala Glu Ile Val Ala Arg Gln Ser Ser Ala Tyr 
225                 230                 235                 240 


Pro Gly Leu Asp Trp Pro Ala Val Thr Arg Leu Val Leu Asp Gln Arg 
                245                 250                 255     


Pro Leu Arg Ser Lys Gly Ala Gly Pro Cys Ala Phe Leu Pro Gly Glu 
            260                 265                 270         


Asp Arg Ala Leu Arg Ala Leu Pro Thr Val Gln Asp Phe Ile Ile Arg 
        275                 280                 285             


Gln Thr Leu Ala Asn Leu Arg Leu Pro Ser Thr Ser Ala Asp Glu Pro 
    290                 295                 300                 


Arg Pro Leu Thr Asp Glu Glu His Ala Lys Ala Leu Ala Leu Leu Ser 
305                 310                 315                 320 


Thr Ala Arg Phe Val Glu Trp Pro Ala Leu Arg Arg Ala Leu Gly Leu 
                325                 330                 335     


Lys Arg Gly Val Lys Phe Thr Ala Glu Thr Glu Arg Asn Gly Ala Lys 
            340                 345                 350         


Gln Ala Ala Arg Gly Thr Ala Gly Asn Leu Thr Glu Ala Ile Leu Ala 
        355                 360                 365             


Pro Leu Ile Pro Gly Trp Ser Gly Trp Asp Leu Asp Arg Lys Asp Arg 
    370                 375                 380                 


Val Phe Ser Asp Leu Trp Ala Ala Arg Gln Asp Arg Ser Ala Leu Leu 
385                 390                 395                 400 


Ala Leu Ile Gly Asp Pro Arg Gly Pro Thr Arg Val Thr Glu Asp Glu 
                405                 410                 415     


Thr Ala Glu Ala Val Ala Asp Ala Ile Gln Ile Val Leu Pro Thr Gly 
            420                 425                 430         


Arg Ala Ser Leu Ser Ala Lys Ala Ala Arg Ala Ile Ala Gln Ala Met 
        435                 440                 445             


Ala Pro Gly Ile Gly Tyr Asp Glu Ala Val Thr Leu Ala Leu Gly Leu 
    450                 455                 460                 


His His Ser His Arg Pro Arg Gln Glu Arg Leu Ala Arg Leu Pro Tyr 
465                 470                 475                 480 


Tyr Ala Ala Ala Leu Pro Asp Val Gly Leu Asp Gly Asp Pro Val Gly 
                485                 490                 495     


Pro Pro Pro Ala Glu Asp Asp Gly Ala Ala Ala Glu Ala Tyr Tyr Gly 
            500                 505                 510         


Arg Ile Gly Asn Ile Ser Val His Ile Ala Leu Asn Glu Thr Arg Lys 
        515                 520                 525             


Ile Val Asn Ala Leu Leu His Arg His Gly Pro Ile Leu Arg Leu Val 
    530                 535                 540                 


Met Val Glu Thr Thr Arg Glu Leu Lys Ala Gly Ala Asp Glu Arg Lys 
545                 550                 555                 560 


Arg Met Ile Ala Glu Gln Ala Glu Arg Glu Arg Glu Asn Ala Glu Ile 
                565                 570                 575     


Asp Val Glu Leu Arg Lys Ser Asp Arg Trp Met Ala Asn Ala Arg Glu 
            580                 585                 590         


Arg Arg Gln Arg Val Arg Leu Ala Arg Arg Gln Asn Asn Leu Cys Pro 
        595                 600                 605             


Tyr Thr Ser Thr Pro Ile Gly His Ala Asp Leu Leu Gly Asp Ala Tyr 
    610                 615                 620                 


Asp Ile Asp His Val Ile Pro Leu Ala Arg Gly Gly Arg Asp Ser Leu 
625                 630                 635                 640 


Asp Asn Met Val Leu Cys Gln Ser Asp Ala Asn Lys Thr Lys Gly Asp 
                645                 650                 655     


Lys Thr Pro Trp Glu Ala Phe His Asp Lys Pro Gly Trp Ile Ala Gln 
            660                 665                 670         


Arg Asp Asp Phe Leu Ala Arg Leu Asp Pro Gln Thr Ala Lys Ala Leu 
        675                 680                 685             


Ala Trp Arg Phe Ala Asp Asp Ala Gly Glu Arg Val Ala Arg Lys Ser 
    690                 695                 700                 


Ala Glu Asp Glu Asp Gln Gly Phe Leu Pro Arg Gln Leu Thr Asp Thr 
705                 710                 715                 720 


Gly Tyr Ile Ala Arg Val Ala Leu Arg Tyr Leu Ser Leu Val Thr Asn 
                725                 730                 735     


Glu Pro Asn Ala Val Val Ala Thr Asn Gly Arg Leu Thr Gly Leu Leu 
            740                 745                 750         


Arg Leu Ala Trp Asp Ile Thr Pro Gly Pro Ala Pro Arg Asp Leu Leu 
        755                 760                 765             


Pro Thr Pro Arg Asp Ala Leu Arg Asp Asp Thr Ala Ala Arg Arg Phe 
    770                 775                 780                 


Leu Asp Gly Leu Thr Pro Pro Pro Leu Ala Lys Ala Val Glu Gly Ala 
785                 790                 795                 800 


Val Gln Ala Arg Leu Ala Ala Leu Gly Arg Ser Arg Val Ala Asp Ala 
                805                 810                 815     


Gly Leu Ala Asp Ala Leu Gly Leu Thr Leu Ala Ser Leu Gly Gly Gly 
            820                 825                 830         


Gly Lys Asn Arg Ala Asp His Arg His His Phe Ile Asp Ala Ala Met 
        835                 840                 845             


Ile Ala Val Thr Thr Arg Gly Leu Ile Asn Gln Ile Asn Gln Ala Ser 
    850                 855                 860                 


Gly Ala Gly Arg Ile Leu Asp Leu Arg Lys Trp Pro Arg Thr Asn Phe 
865                 870                 875                 880 


Glu Pro Pro Tyr Pro Thr Phe Arg Ala Glu Val Met Lys Gln Trp Asp 
                885                 890                 895     


His Ile His Pro Ser Ile Arg Pro Ala His Arg Asp Gly Gly Ser Leu 
            900                 905                 910         


His Ala Ala Thr Val Phe Gly Val Arg Asn Arg Pro Asp Ala Arg Val 
        915                 920                 925             


Leu Val Gln Arg Lys Pro Val Glu Lys Leu Phe Leu Asp Ala Asn Ala 
    930                 935                 940                 


Lys Pro Leu Pro Ala Asp Lys Ile Ala Glu Ile Ile Asp Gly Phe Ala 
945                 950                 955                 960 


Ser Pro Arg Met Ala Lys Arg Phe Lys Ala Leu Leu Ala Arg Tyr Gln 
                965                 970                 975     


Ala Ala His Pro Glu Val Pro Pro Ala Leu Ala Ala Leu Ala Val Ala 
            980                 985                 990         


Arg Asp Pro Ala Phe Gly Pro Arg  Gly Met Thr Ala Asn  Thr Val Ile 
        995                 1000                 1005             


Ala Gly  Arg Ser Asp Gly Asp  Gly Glu Asp Ala Gly  Leu Ile Thr 
    1010                 1015                 1020             


Pro Phe  Arg Ala Asn Pro Lys  Ala Ala Val Arg Thr  Met Gly Asn 
    1025                 1030                 1035             


Ala Val  Tyr Glu Val Trp Glu  Ile Gln Val Lys Gly  Arg Pro Arg 
    1040                 1045                 1050             


Trp Thr  His Arg Val Leu Thr  Arg Phe Asp Arg Thr  Gln Pro Ala 
    1055                 1060                 1065             


Pro Pro  Pro Pro Pro Glu Asn  Ala Arg Leu Val Met  Arg Leu Arg 
    1070                 1075                 1080             


Arg Gly  Asp Leu Val Tyr Trp  Pro Leu Glu Ser Gly  Asp Arg Leu 
    1085                 1090                 1095             


Phe Leu  Val Lys Lys Met Ala  Val Asp Gly Arg Leu  Ala Leu Trp 
    1100                 1105                 1110             


Pro Ala  Arg Leu Ala Thr Gly  Lys Ala Thr Ala Leu  Tyr Ala Gln 
    1115                 1120                 1125             


Leu Ser  Cys Pro Asn Ile Asn  Leu Asn Gly Asp Gln  Gly Tyr Cys 
    1130                 1135                 1140             


Val Gln  Ser Ala Glu Gly Ile  Arg Lys Glu Lys Ile  Arg Thr Thr 
    1145                 1150                 1155             


Ser Cys  Thr Ala Leu Gly Arg  Leu Arg Leu Ser Lys  Lys Ala Thr 
    1160                 1165                 1170             


<210>  749
<211>  1035
<212>  PRT
<213>  Candidatus Puniceispirillum marinum IMCC1322

<400>  749

Met Arg Arg Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp Cys 
1               5                   10                  15      


Leu Leu Asp Leu Gly Asp Asp Gly Glu Pro Val Ser Ile Phe Arg Thr 
            20                  25                  30          


Gly Ala Arg Ile Phe Ser Asp Gly Arg Asp Pro Lys Ser Leu Gly Ser 
        35                  40                  45              


Leu Lys Ala Thr Arg Arg Glu Ala Arg Leu Thr Arg Arg Arg Arg Asp 
    50                  55                  60                  


Arg Phe Ile Gln Arg Gln Lys Asn Leu Ile Asn Ala Leu Val Lys Tyr 
65                  70                  75                  80  


Gly Leu Met Pro Ala Asp Glu Ile Gln Arg Gln Ala Leu Ala Tyr Lys 
                85                  90                  95      


Asp Pro Tyr Pro Ile Arg Lys Lys Ala Leu Asp Glu Ala Ile Asp Pro 
            100                 105                 110         


Tyr Glu Met Gly Arg Ala Ile Phe His Ile Asn Gln Arg Arg Gly Phe 
        115                 120                 125             


Lys Ser Asn Arg Lys Ser Ala Asp Asn Glu Ala Gly Val Val Lys Gln 
    130                 135                 140                 


Ser Ile Ala Asp Leu Glu Met Lys Leu Gly Glu Ala Gly Ala Arg Thr 
145                 150                 155                 160 


Ile Gly Glu Phe Leu Ala Asp Arg Gln Ala Thr Asn Asp Thr Val Arg 
                165                 170                 175     


Ala Arg Arg Leu Ser Gly Thr Asn Ala Leu Tyr Glu Phe Tyr Pro Asp 
            180                 185                 190         


Arg Tyr Met Leu Glu Gln Glu Phe Asp Thr Leu Trp Ala Lys Gln Ala 
        195                 200                 205             


Ala Phe Asn Pro Ser Leu Tyr Ile Glu Ala Ala Arg Glu Arg Leu Lys 
    210                 215                 220                 


Glu Ile Val Phe Phe Gln Arg Lys Leu Lys Pro Gln Glu Val Gly Arg 
225                 230                 235                 240 


Cys Ile Phe Leu Ser Asp Glu Asp Arg Ile Ser Lys Ala Leu Pro Ser 
                245                 250                 255     


Phe Gln Arg Phe Arg Ile Tyr Gln Glu Leu Ser Asn Leu Ala Trp Ile 
            260                 265                 270         


Asp His Asp Gly Val Ala His Arg Ile Thr Ala Ser Leu Ala Leu Arg 
        275                 280                 285             


Asp His Leu Phe Asp Glu Leu Glu His Lys Lys Lys Leu Thr Phe Lys 
    290                 295                 300                 


Ala Met Arg Ala Ile Leu Arg Lys Gln Gly Val Val Asp Tyr Pro Val 
305                 310                 315                 320 


Gly Phe Asn Leu Glu Ser Asp Asn Arg Asp His Leu Ile Gly Asn Leu 
                325                 330                 335     


Thr Ser Cys Ile Met Arg Asp Ala Lys Lys Met Ile Gly Ser Ala Trp 
            340                 345                 350         


Asp Arg Leu Asp Glu Glu Glu Gln Asp Ser Phe Ile Leu Met Leu Gln 
        355                 360                 365             


Asp Asp Gln Lys Gly Asp Asp Glu Val Arg Ser Ile Leu Thr Gln Gln 
    370                 375                 380                 


Tyr Gly Leu Ser Asp Asp Val Ala Glu Asp Cys Leu Asp Val Arg Leu 
385                 390                 395                 400 


Pro Asp Gly His Gly Ser Leu Ser Lys Lys Ala Ile Asp Arg Ile Leu 
                405                 410                 415     


Pro Val Leu Arg Asp Gln Gly Leu Ile Tyr Tyr Asp Ala Val Lys Glu 
            420                 425                 430         


Ala Gly Leu Gly Glu Ala Asn Leu Tyr Asp Pro Tyr Ala Ala Leu Ser 
        435                 440                 445             


Asp Lys Leu Asp Tyr Tyr Gly Lys Ala Leu Ala Gly His Val Met Gly 
    450                 455                 460                 


Ala Ser Gly Lys Phe Glu Asp Ser Asp Glu Lys Arg Tyr Gly Thr Ile 
465                 470                 475                 480 


Ser Asn Pro Thr Val His Ile Ala Leu Asn Gln Val Arg Ala Val Val 
                485                 490                 495     


Asn Glu Leu Ile Arg Leu His Gly Lys Pro Asp Glu Val Val Ile Glu 
            500                 505                 510         


Ile Gly Arg Asp Leu Pro Met Gly Ala Asp Gly Lys Arg Glu Leu Glu 
        515                 520                 525             


Arg Phe Gln Lys Glu Gly Arg Ala Lys Asn Glu Arg Ala Arg Asp Glu 
    530                 535                 540                 


Leu Lys Lys Leu Gly His Ile Asp Ser Arg Glu Ser Arg Gln Lys Phe 
545                 550                 555                 560 


Gln Leu Trp Glu Gln Leu Ala Lys Glu Pro Val Asp Arg Cys Cys Pro 
                565                 570                 575     


Phe Thr Gly Lys Met Met Ser Ile Ser Asp Leu Phe Ser Asp Lys Val 
            580                 585                 590         


Glu Ile Glu His Leu Leu Pro Phe Ser Leu Thr Leu Asp Asp Ser Met 
        595                 600                 605             


Ala Asn Lys Thr Val Cys Phe Arg Gln Ala Asn Arg Asp Lys Gly Asn 
    610                 615                 620                 


Arg Ala Pro Phe Asp Ala Phe Gly Asn Ser Pro Ala Gly Tyr Asp Trp 
625                 630                 635                 640 


Gln Glu Ile Leu Gly Arg Ser Gln Asn Leu Pro Tyr Ala Lys Arg Trp 
                645                 650                 655     


Arg Phe Leu Pro Asp Ala Met Lys Arg Phe Glu Ala Asp Gly Gly Phe 
            660                 665                 670         


Leu Glu Arg Gln Leu Asn Asp Thr Arg Tyr Ile Ser Arg Tyr Thr Thr 
        675                 680                 685             


Glu Tyr Ile Ser Thr Ile Ile Pro Lys Asn Lys Ile Trp Val Val Thr 
    690                 695                 700                 


Gly Arg Leu Thr Ser Leu Leu Arg Gly Phe Trp Gly Leu Asn Ser Ile 
705                 710                 715                 720 


Leu Arg Gly His Asn Thr Asp Asp Gly Thr Pro Ala Lys Lys Ser Arg 
                725                 730                 735     


Asp Asp His Arg His His Ala Ile Asp Ala Ile Val Val Gly Met Thr 
            740                 745                 750         


Ser Arg Gly Leu Leu Gln Lys Val Ser Lys Ala Ala Arg Arg Ser Glu 
        755                 760                 765             


Asp Leu Asp Leu Thr Arg Leu Phe Glu Gly Arg Ile Asp Pro Trp Asp 
    770                 775                 780                 


Gly Phe Arg Asp Glu Val Lys Lys His Ile Asp Ala Ile Ile Val Ser 
785                 790                 795                 800 


His Arg Pro Arg Lys Lys Ser Gln Gly Ala Leu His Asn Asp Thr Ala 
                805                 810                 815     


Tyr Gly Ile Val Glu His Ala Glu Asn Gly Ala Ser Thr Val Val His 
            820                 825                 830         


Arg Val Pro Ile Thr Ser Leu Gly Lys Gln Ser Asp Ile Glu Lys Val 
        835                 840                 845             


Arg Asp Pro Leu Ile Lys Ser Ala Leu Leu Asn Glu Thr Ala Gly Leu 
    850                 855                 860                 


Ser Gly Lys Ser Phe Glu Asn Ala Val Gln Lys Trp Cys Ala Asp Asn 
865                 870                 875                 880 


Ser Ile Lys Ser Leu Arg Ile Val Glu Thr Val Ser Ile Ile Pro Ile 
                885                 890                 895     


Thr Asp Lys Glu Gly Val Ala Tyr Lys Gly Tyr Lys Gly Asp Gly Asn 
            900                 905                 910         


Ala Tyr Met Asp Ile Tyr Gln Asp Pro Thr Ser Ser Lys Trp Lys Gly 
        915                 920                 925             


Glu Ile Val Ser Arg Phe Asp Ala Asn Gln Lys Gly Phe Ile Pro Ser 
    930                 935                 940                 


Trp Gln Ser Gln Phe Pro Thr Ala Arg Leu Ile Met Arg Leu Arg Ile 
945                 950                 955                 960 


Asn Asp Leu Leu Lys Leu Gln Asp Gly Glu Ile Glu Glu Ile Tyr Arg 
                965                 970                 975     


Val Gln Arg Leu Ser Gly Ser Lys Ile Leu Met Ala Pro His Thr Glu 
            980                 985                 990         


Ala Asn Val Asp Ala Arg Asp Arg  Asp Lys Asn Asp Thr  Phe Lys Leu 
        995                 1000                 1005             


Thr Ser  Lys Ser Pro Gly Lys  Leu Gln Ser Ala Ser  Ala Arg Lys 
    1010                 1015                 1020             


Val His  Ile Ser Pro Thr Gly  Leu Ile Arg Glu Gly  
    1025                 1030                 1035 


<210>  750
<211>  1068
<212>  PRT
<213>  Verminephrobacter eiseniae EF01-2

<400>  750

Met Asn Lys Ala Val Ala Tyr Arg Leu Ala Leu Asp Leu Gly Ser Thr 
1               5                   10                  15      


Ser Leu Gly Trp Ala Ile Phe Arg Leu Asn Glu Ala Arg Glu Pro Thr 
            20                  25                  30          


Ala Ile Ile Arg Ala Gly Val Arg Ile Phe Ser Asp Gly Arg Asn Ala 
        35                  40                  45              


Asn Ser Glu Pro Leu Ala Val His Arg Arg Val Ala Arg Ala Met Arg 
    50                  55                  60                  


Arg Arg Arg Asp Arg Leu Leu Lys Arg Lys Lys Arg Met His Asp Gln 
65                  70                  75                  80  


Leu Val Gln His Gly Phe Phe Pro Ala Glu Val Ala Glu Arg Lys Glu 
                85                  90                  95      


Leu Glu Arg Leu Asn Pro Tyr Gln Leu Arg Ala Lys Gly Leu His Glu 
            100                 105                 110         


Ala Leu Thr Pro Gly Glu Phe Ala Arg Ala Leu Phe His Ile Asn Gln 
        115                 120                 125             


Arg Arg Gly Phe Lys Ser Asn Arg Lys Thr Asp Arg Lys Asp Asn Asp 
    130                 135                 140                 


Ser Gly Ala Leu Lys Gln Ala Ile Ser Glu Leu Arg Lys Arg Ile Gln 
145                 150                 155                 160 


Asp Ser Asp Cys Ala Thr Ala Gly Glu Trp Phe Trp Lys Glu Arg Met 
                165                 170                 175     


Gln Gln Lys Pro Glu Gly Val Arg Gly Gln Trp Val Arg Ala Arg Tyr 
            180                 185                 190         


Arg Lys Thr Pro Ser Thr Thr Asp Glu Gly Lys Lys Arg Ile Gly Tyr 
        195                 200                 205             


Asp Leu Tyr Val Asp Arg Ala Met Val Glu Gln Glu Phe Asp Ala Leu 
    210                 215                 220                 


Trp Ala Ala Gln Ala Ala Leu Gln Pro Gly Leu Phe Thr Glu Ala Ala 
225                 230                 235                 240 


Arg Ala Glu Leu Lys Asp Thr Leu Leu Tyr Gln Arg Asp Leu Arg Pro 
                245                 250                 255     


Val Lys Pro Gly Arg Cys Thr Leu Leu Pro Ala Glu Glu Arg Ala Pro 
            260                 265                 270         


Leu Ala Leu Pro Ser Thr Gln Arg Phe Arg Ile Leu Gln Glu Val Asn 
        275                 280                 285             


Asn Leu Arg Leu Leu Asp Glu Ala Leu Arg Glu Val Pro Leu Asn Leu 
    290                 295                 300                 


Ala Gln Arg Asp Ala Val Val Ser Ala Leu Glu Gly Lys Lys Glu Leu 
305                 310                 315                 320 


Ser Phe Ala Ala Ile Arg Lys Leu Leu Thr Leu Ser Gly Lys Phe Asn 
                325                 330                 335     


Leu Glu Asp Glu Lys Arg Ala Glu Leu Lys Gly Asn Ala Thr Ser Val 
            340                 345                 350         


Ile Leu Ala Arg Lys Asp Leu Phe Gly Asp Ala Trp Ala Gly Phe Asp 
        355                 360                 365             


Ala Ala Val Gln Asp Glu Ile Val Trp Arg Leu Val Ser Gln Glu Ser 
    370                 375                 380                 


Glu Gly Ala Leu Ile Ala Trp Leu Gln Gln His Thr Gly Val Asp Gly 
385                 390                 395                 400 


Val Cys Ala Glu Ala Ile Val Asn Thr Arg Leu Pro Asp Gly Tyr Gly 
                405                 410                 415     


Arg Leu Ser Arg Lys Ala Leu Glu Arg Ile Val Pro Ala Leu Gln Arg 
            420                 425                 430         


Glu Val Cys Thr Tyr Asp Lys Ala Val Gln Ala Ala Gly Phe Ala His 
        435                 440                 445             


His Ser Asp Leu Gly Phe Asp Phe Asp Tyr Ala Glu Asp Glu Val Gln 
    450                 455                 460                 


Gln Val Gly Glu His Thr Ile Ala Ser Thr Gly Glu Val Gln Ala Gln 
465                 470                 475                 480 


Tyr Ala Phe Lys Gln Leu Pro Tyr Tyr Gly Lys Ala Leu Gln Arg His 
                485                 490                 495     


Val Ala Phe Gly Ser Gly Asp Ala Lys Asp His Glu Glu Lys Cys Tyr 
            500                 505                 510         


Gly Lys Ile Ala Asn Pro Thr Val His Ile Gly Leu Asn Gln Val Arg 
        515                 520                 525             


Thr Val Val Asn Ala Leu Ile Arg Arg Tyr Gly His Pro Thr Glu Val 
    530                 535                 540                 


Val Val Glu Leu Ala Arg Asp Leu Lys Gln Ser Arg Glu Gln Lys Gln 
545                 550                 555                 560 


Gln Thr Gln Arg Glu Gln Ala Asp Asn Gln Lys Arg Asn Glu Asp Ile 
                565                 570                 575     


Arg Lys Arg Ile Ala Pro Ile Leu Glu Thr Ser Pro Glu Arg Val Arg 
            580                 585                 590         


Asp Arg Asp Ile Lys Lys Trp Ile Leu Trp Glu Glu Leu Asn Lys Lys 
        595                 600                 605             


Asp Ile Ala Asp Arg His Cys Pro Tyr Ser Gly Glu Arg Ile Ser Ala 
    610                 615                 620                 


Thr Met Leu Leu Ser Glu Ala Val Glu Ile Glu His Ile Leu Pro Phe 
625                 630                 635                 640 


Ser Arg Thr Leu Asp Asp Ser Leu Asn Asn Arg Thr Val Ala Met Arg 
                645                 650                 655     


Arg Ala Asn Arg Ile Lys Gly Asp Arg Thr Pro Trp Glu Ala Arg Ala 
            660                 665                 670         


Asp Phe Glu Ala Gln Gly Trp Arg Tyr Glu Ala Ile Leu Gln Arg Ala 
        675                 680                 685             


Glu Gly Met Pro Pro Arg Lys Arg Tyr Arg Phe Ala Glu Asp Gly Tyr 
    690                 695                 700                 


Gln Arg Trp Leu Gly Lys Asp Arg Asn Phe Leu Ala Arg Ala Leu Asn 
705                 710                 715                 720 


Asp Thr Ser Tyr Leu Ser Arg Leu Ala Ala Asn Tyr Leu Arg Leu Val 
                725                 730                 735     


Cys Pro Gln Gly Val Arg Val Ile Pro Gly Gln Met Thr Asp Lys Leu 
            740                 745                 750         


Arg Gly Lys Phe Gly Leu Asn Ser Val Leu Gly Leu Asp Gly Lys Lys 
        755                 760                 765             


Asn Arg Asn Asp His Arg His His Ala Val Asp Ala Cys Val Ile Gly 
    770                 775                 780                 


Val Thr Asp Gln Gly Leu Met Gln Arg Phe Ala Asn Ala Ser Lys Gln 
785                 790                 795                 800 


Ala Arg Glu Asn Gly Leu Thr Arg Leu Val Gln Asp Met Leu Leu Pro 
                805                 810                 815     


Trp Trp Pro Ser Tyr Tyr Asp His Val Glu Arg Ala Val Arg His Ile 
            820                 825                 830         


Arg Val Ser His Arg Pro Asp His Gly Phe Glu Gly Ala Met Met Lys 
        835                 840                 845             


Gly Thr Ala His Gly Ile Arg Glu Asp Gly Ile Arg Glu Asp Gly Arg 
    850                 855                 860                 


Ile Lys Gln Arg Pro Lys Ala Lys Gly Ser Ala Asp His Lys Thr Ile 
865                 870                 875                 880 


Thr Leu Ile Pro Ile Asp Glu Pro Arg Gln Leu Ala Arg His Gly Val 
                885                 890                 895     


Asp Ala Glu Gly Lys Pro Leu Pro Tyr Lys Gly Tyr Ala Ser Gly Ser 
            900                 905                 910         


Asn Tyr Cys Ile Glu Ile Thr Lys Asn Gly Lys Gly Lys Trp Glu Gly 
        915                 920                 925             


Gln Val Ile Ser Thr Phe Asp Ala Tyr Arg Ile Lys Ala Ala Ala Asp 
    930                 935                 940                 


Ala Ala Ala Arg Ala Gly Gln Val Ile Ser Thr Val Glu Ala Asp Ser 
945                 950                 955                 960 


Ile Val Arg Lys Ser Gly Trp Glu Arg Leu Arg Gly Ala Gln Ser Gln 
                965                 970                 975     


Asn Gly Gln Pro Leu Val Met Arg Leu Val Ile Gly Asp Ser Val Arg 
            980                 985                 990         


Met Glu Val Asp Gly Arg Asp Glu  Val Met Arg Val Val  Lys Met Ser 
        995                 1000                 1005             


Gly Lys  Glu Met Val Phe Ala  Pro Val Arg Glu Ala  Asn Val Asp 
    1010                 1015                 1020             


Lys Arg  Asn Asn Met Pro Asp  Glu Gln Asp Pro Phe  Thr Tyr Thr 
    1025                 1030                 1035             


Tyr Lys  Arg Ala Asp Gln Leu  Arg Lys Ala Lys Ala  Arg Gln Val 
    1040                 1045                 1050             


Thr Ile  Ser Pro Ile Gly Glu  Leu Arg Asp Pro Gly  Phe Lys Gly 
    1055                 1060                 1065             


<210>  751
<211>  1062
<212>  PRT
<213>  Ralstonia syzygii R24

<400>  751

Met Ala Glu Lys Gln His Arg Trp Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Ile Gly Trp Ala Val Ile Ala Leu Ile Glu Gly Arg Pro Ala Gly Leu 
            20                  25                  30          


Val Ala Thr Gly Ser Arg Ile Phe Ser Asp Gly Arg Asn Pro Lys Asp 
        35                  40                  45              


Gly Ser Ser Leu Ala Val Glu Arg Arg Gly Pro Arg Gln Met Arg Arg 
    50                  55                  60                  


Arg Arg Asp Arg Tyr Leu Arg Arg Arg Asp Arg Phe Met Gln Ala Leu 
65                  70                  75                  80  


Ile Asn Val Gly Leu Met Pro Gly Asp Ala Ala Ala Arg Lys Ala Leu 
                85                  90                  95      


Val Thr Glu Asn Pro Tyr Val Leu Arg Gln Arg Gly Leu Asp Gln Ala 
            100                 105                 110         


Leu Thr Leu Pro Glu Phe Gly Arg Ala Leu Phe His Leu Asn Gln Arg 
        115                 120                 125             


Arg Gly Phe Gln Ser Asn Arg Lys Thr Asp Arg Ala Thr Ala Lys Glu 
    130                 135                 140                 


Ser Gly Lys Val Lys Asn Ala Ile Ala Ala Phe Arg Ala Gly Met Gly 
145                 150                 155                 160 


Asn Ala Arg Thr Val Gly Glu Ala Leu Ala Arg Arg Leu Glu Asp Gly 
                165                 170                 175     


Arg Pro Val Arg Ala Arg Met Val Gly Gln Gly Lys Asp Glu His Tyr 
            180                 185                 190         


Glu Leu Tyr Ile Ala Arg Glu Trp Ile Ala Gln Glu Phe Asp Ala Leu 
        195                 200                 205             


Trp Ala Ser Gln Gln Arg Phe His Ala Glu Val Leu Ala Asp Ala Ala 
    210                 215                 220                 


Arg Asp Arg Leu Arg Ala Ile Leu Leu Phe Gln Arg Lys Leu Leu Pro 
225                 230                 235                 240 


Val Pro Val Gly Lys Cys Phe Leu Glu Pro Asn Gln Pro Arg Val Ala 
                245                 250                 255     


Ala Ala Leu Pro Ser Ala Gln Arg Phe Arg Leu Met Gln Glu Leu Asn 
            260                 265                 270         


His Leu Arg Val Met Thr Leu Ala Asp Lys Arg Glu Arg Pro Leu Ser 
        275                 280                 285             


Phe Gln Glu Arg Asn Asp Leu Leu Ala Gln Leu Val Ala Arg Pro Lys 
    290                 295                 300                 


Cys Gly Phe Asp Met Leu Arg Lys Ile Val Phe Gly Ala Asn Lys Glu 
305                 310                 315                 320 


Ala Tyr Arg Phe Thr Ile Glu Ser Glu Arg Arg Lys Glu Leu Lys Gly 
                325                 330                 335     


Cys Asp Thr Ala Ala Lys Leu Ala Lys Val Asn Ala Leu Gly Thr Arg 
            340                 345                 350         


Trp Gln Ala Leu Ser Leu Asp Glu Gln Asp Arg Leu Val Cys Leu Leu 
        355                 360                 365             


Leu Asp Gly Glu Asn Asp Ala Val Leu Ala Asp Ala Leu Arg Glu His 
    370                 375                 380                 


Tyr Gly Leu Thr Asp Ala Gln Ile Asp Thr Leu Leu Gly Leu Ser Phe 
385                 390                 395                 400 


Glu Asp Gly His Met Arg Leu Gly Arg Ser Ala Leu Leu Arg Val Leu 
                405                 410                 415     


Asp Ala Leu Glu Ser Gly Arg Asp Glu Gln Gly Leu Pro Leu Ser Tyr 
            420                 425                 430         


Asp Lys Ala Val Val Ala Ala Gly Tyr Pro Ala His Thr Ala Asp Leu 
        435                 440                 445             


Glu Asn Gly Glu Arg Asp Ala Leu Pro Tyr Tyr Gly Glu Leu Leu Trp 
    450                 455                 460                 


Arg Tyr Thr Gln Asp Ala Pro Thr Ala Lys Asn Asp Ala Glu Arg Lys 
465                 470                 475                 480 


Phe Gly Lys Ile Ala Asn Pro Thr Val His Ile Gly Leu Asn Gln Leu 
                485                 490                 495     


Arg Lys Leu Val Asn Ala Leu Ile Gln Arg Tyr Gly Lys Pro Ala Gln 
            500                 505                 510         


Ile Val Val Glu Leu Ala Arg Asn Leu Lys Ala Gly Leu Glu Glu Lys 
        515                 520                 525             


Glu Arg Ile Lys Lys Gln Gln Thr Ala Asn Leu Glu Arg Asn Glu Arg 
    530                 535                 540                 


Ile Arg Gln Lys Leu Gln Asp Ala Gly Val Pro Asp Asn Arg Glu Asn 
545                 550                 555                 560 


Arg Leu Arg Met Arg Leu Phe Glu Glu Leu Gly Gln Gly Asn Gly Leu 
                565                 570                 575     


Gly Thr Pro Cys Ile Tyr Ser Gly Arg Gln Ile Ser Leu Gln Arg Leu 
            580                 585                 590         


Phe Ser Asn Asp Val Gln Val Asp His Ile Leu Pro Phe Ser Lys Thr 
        595                 600                 605             


Leu Asp Asp Ser Phe Ala Asn Lys Val Leu Ala Gln His Asp Ala Asn 
    610                 615                 620                 


Arg Tyr Lys Gly Asn Arg Gly Pro Phe Glu Ala Phe Gly Ala Asn Arg 
625                 630                 635                 640 


Asp Gly Tyr Ala Trp Asp Asp Ile Arg Ala Arg Ala Ala Val Leu Pro 
                645                 650                 655     


Arg Asn Lys Arg Asn Arg Phe Ala Glu Thr Ala Met Gln Asp Trp Leu 
            660                 665                 670         


His Asn Glu Thr Asp Phe Leu Ala Arg Gln Leu Thr Asp Thr Ala Tyr 
        675                 680                 685             


Leu Ser Arg Val Ala Arg Gln Tyr Leu Thr Ala Ile Cys Ser Lys Asp 
    690                 695                 700                 


Asp Val Tyr Val Ser Pro Gly Arg Leu Thr Ala Met Leu Arg Ala Lys 
705                 710                 715                 720 


Trp Gly Leu Asn Arg Val Leu Asp Gly Val Met Glu Glu Gln Gly Arg 
                725                 730                 735     


Pro Ala Val Lys Asn Arg Asp Asp His Arg His His Ala Ile Asp Ala 
            740                 745                 750         


Val Val Ile Gly Ala Thr Asp Arg Ala Met Leu Gln Gln Val Ala Thr 
        755                 760                 765             


Leu Ala Ala Arg Ala Arg Glu Gln Asp Ala Glu Arg Leu Ile Gly Asp 
    770                 775                 780                 


Met Pro Thr Pro Trp Pro Asn Phe Leu Glu Asp Val Arg Ala Ala Val 
785                 790                 795                 800 


Ala Arg Cys Val Val Ser His Lys Pro Asp His Gly Pro Glu Gly Gly 
                805                 810                 815     


Leu His Asn Asp Thr Ala Tyr Gly Ile Val Ala Gly Pro Phe Glu Asp 
            820                 825                 830         


Gly Arg Tyr Arg Val Arg His Arg Val Ser Leu Phe Asp Leu Lys Pro 
        835                 840                 845             


Gly Asp Leu Ser Asn Val Arg Cys Asp Ala Pro Leu Gln Ala Glu Leu 
    850                 855                 860                 


Glu Pro Ile Phe Glu Gln Asp Asp Ala Arg Ala Arg Glu Val Ala Leu 
865                 870                 875                 880 


Thr Ala Leu Ala Glu Arg Tyr Arg Gln Arg Lys Val Trp Leu Glu Glu 
                885                 890                 895     


Leu Met Ser Val Leu Pro Ile Arg Pro Arg Gly Glu Asp Gly Lys Thr 
            900                 905                 910         


Leu Pro Asp Ser Ala Pro Tyr Lys Ala Tyr Lys Gly Asp Ser Asn Tyr 
        915                 920                 925             


Cys Tyr Glu Leu Phe Ile Asn Glu Arg Gly Arg Trp Asp Gly Glu Leu 
    930                 935                 940                 


Ile Ser Thr Phe Arg Ala Asn Gln Ala Ala Tyr Arg Arg Phe Arg Asn 
945                 950                 955                 960 


Asp Pro Ala Arg Phe Arg Arg Tyr Thr Ala Gly Gly Arg Pro Leu Leu 
                965                 970                 975     


Met Arg Leu Cys Ile Asn Asp Tyr Ile Ala Val Gly Thr Ala Ala Glu 
            980                 985                 990         


Arg Thr Ile Phe Arg Val Val Lys  Met Ser Glu Asn Lys  Ile Thr Leu 
        995                 1000                 1005             


Ala Glu  His Phe Glu Gly Gly  Thr Leu Lys Gln Arg  Asp Ala Asp 
    1010                 1015                 1020             


Lys Asp  Asp Pro Phe Lys Tyr  Leu Thr Lys Ser Pro  Gly Ala Leu 
    1025                 1030                 1035             


Arg Asp  Leu Gly Ala Arg Arg  Ile Phe Val Asp Leu  Ile Gly Arg 
    1040                 1045                 1050             


Val Leu  Asp Pro Gly Ile Lys  Gly Asp 
    1055                 1060         


<210>  752
<211>  1079
<212>  PRT
<213>  Dinoroseobacter shibae DFL 12

<400>  752

Met Arg Leu Gly Leu Asp Ile Gly Thr Ser Ser Ile Gly Trp Trp Leu 
1               5                   10                  15      


Tyr Glu Thr Asp Gly Ala Gly Ser Asp Ala Arg Ile Thr Gly Val Val 
            20                  25                  30          


Asp Gly Gly Val Arg Ile Phe Ser Asp Gly Arg Asp Pro Lys Ser Gly 
        35                  40                  45              


Ala Ser Leu Ala Val Asp Arg Arg Ala Ala Arg Ala Met Arg Arg Arg 
    50                  55                  60                  


Arg Asp Arg Tyr Leu Arg Arg Arg Ala Thr Leu Met Lys Val Leu Ala 
65                  70                  75                  80  


Glu Thr Gly Leu Met Pro Ala Asp Pro Ala Glu Ala Lys Ala Leu Glu 
                85                  90                  95      


Ala Leu Asp Pro Phe Ala Leu Arg Ala Ala Gly Leu Asp Glu Pro Leu 
            100                 105                 110         


Pro Leu Pro His Leu Gly Arg Ala Leu Phe His Leu Asn Gln Arg Arg 
        115                 120                 125             


Gly Phe Lys Ser Asn Arg Lys Thr Asp Arg Gly Asp Asn Glu Ser Gly 
    130                 135                 140                 


Lys Ile Lys Asp Ala Thr Ala Arg Leu Asp Met Glu Met Met Ala Asn 
145                 150                 155                 160 


Gly Ala Arg Thr Tyr Gly Glu Phe Leu His Lys Arg Arg Gln Lys Ala 
                165                 170                 175     


Thr Asp Pro Arg His Val Pro Ser Val Arg Thr Arg Leu Ser Ile Ala 
            180                 185                 190         


Asn Arg Gly Gly Pro Asp Gly Lys Glu Glu Ala Gly Tyr Asp Phe Tyr 
        195                 200                 205             


Pro Asp Arg Arg His Leu Glu Glu Glu Phe His Lys Leu Trp Ala Ala 
    210                 215                 220                 


Gln Gly Ala His His Pro Glu Leu Thr Glu Thr Leu Arg Asp Leu Leu 
225                 230                 235                 240 


Phe Glu Lys Ile Phe Phe Gln Arg Pro Leu Lys Glu Pro Glu Val Gly 
                245                 250                 255     


Leu Cys Leu Phe Ser Gly His His Gly Val Pro Pro Lys Asp Pro Arg 
            260                 265                 270         


Leu Pro Lys Ala His Pro Leu Thr Gln Arg Arg Val Leu Tyr Glu Thr 
        275                 280                 285             


Val Asn Gln Leu Arg Val Thr Ala Asp Gly Arg Glu Ala Arg Pro Leu 
    290                 295                 300                 


Thr Arg Glu Glu Arg Asp Gln Val Ile His Ala Leu Asp Asn Lys Lys 
305                 310                 315                 320 


Pro Thr Lys Ser Leu Ser Ser Met Val Leu Lys Leu Pro Ala Leu Ala 
                325                 330                 335     


Lys Val Leu Lys Leu Arg Asp Gly Glu Arg Phe Thr Leu Glu Thr Gly 
            340                 345                 350         


Val Arg Asp Ala Ile Ala Cys Asp Pro Leu Arg Ala Ser Pro Ala His 
        355                 360                 365             


Pro Asp Arg Phe Gly Pro Arg Trp Ser Ile Leu Asp Ala Asp Ala Gln 
    370                 375                 380                 


Trp Glu Val Ile Ser Arg Ile Arg Arg Val Gln Ser Asp Ala Glu His 
385                 390                 395                 400 


Ala Ala Leu Val Asp Trp Leu Thr Glu Ala His Gly Leu Asp Arg Ala 
                405                 410                 415     


His Ala Glu Ala Thr Ala His Ala Pro Leu Pro Asp Gly Tyr Gly Arg 
            420                 425                 430         


Leu Gly Leu Thr Ala Thr Thr Arg Ile Leu Tyr Gln Leu Thr Ala Asp 
        435                 440                 445             


Val Val Thr Tyr Ala Asp Ala Val Lys Ala Cys Gly Trp His His Ser 
    450                 455                 460                 


Asp Gly Arg Thr Gly Glu Cys Phe Asp Arg Leu Pro Tyr Tyr Gly Glu 
465                 470                 475                 480 


Val Leu Glu Arg His Val Ile Pro Gly Ser Tyr His Pro Asp Asp Asp 
                485                 490                 495     


Asp Ile Thr Arg Phe Gly Arg Ile Thr Asn Pro Thr Val His Ile Gly 
            500                 505                 510         


Leu Asn Gln Leu Arg Arg Leu Val Asn Arg Ile Ile Glu Thr His Gly 
        515                 520                 525             


Lys Pro His Gln Ile Val Val Glu Leu Ala Arg Asp Leu Lys Lys Ser 
    530                 535                 540                 


Glu Glu Gln Lys Arg Ala Asp Ile Lys Arg Ile Arg Asp Thr Thr Glu 
545                 550                 555                 560 


Ala Ala Lys Lys Arg Ser Glu Lys Leu Glu Glu Leu Glu Ile Glu Asp 
                565                 570                 575     


Asn Gly Arg Asn Arg Met Leu Leu Arg Leu Trp Glu Asp Leu Asn Pro 
            580                 585                 590         


Asp Asp Ala Met Arg Arg Phe Cys Pro Tyr Thr Gly Thr Arg Ile Ser 
        595                 600                 605             


Ala Ala Met Ile Phe Asp Gly Ser Cys Asp Val Asp His Ile Leu Pro 
    610                 615                 620                 


Tyr Ser Arg Thr Leu Asp Asp Ser Phe Pro Asn Arg Thr Leu Cys Leu 
625                 630                 635                 640 


Arg Glu Ala Asn Arg Gln Lys Arg Asn Gln Thr Pro Trp Gln Ala Trp 
                645                 650                 655     


Gly Asp Thr Pro His Trp His Ala Ile Ala Ala Asn Leu Lys Asn Leu 
            660                 665                 670         


Pro Glu Asn Lys Arg Trp Arg Phe Ala Pro Asp Ala Met Thr Arg Phe 
        675                 680                 685             


Glu Gly Glu Asn Gly Phe Leu Asp Arg Ala Leu Lys Asp Thr Gln Tyr 
    690                 695                 700                 


Leu Ala Arg Ile Ser Arg Ser Tyr Leu Asp Thr Leu Phe Thr Lys Gly 
705                 710                 715                 720 


Gly His Val Trp Val Val Pro Gly Arg Phe Thr Glu Met Leu Arg Arg 
                725                 730                 735     


His Trp Gly Leu Asn Ser Leu Leu Ser Asp Ala Gly Arg Gly Ala Val 
            740                 745                 750         


Lys Ala Lys Asn Arg Thr Asp His Arg His His Ala Ile Asp Ala Ala 
        755                 760                 765             


Val Ile Ala Ala Thr Asp Pro Gly Leu Leu Asn Arg Ile Ser Arg Ala 
    770                 775                 780                 


Ala Gly Gln Gly Glu Ala Ala Gly Gln Ser Ala Glu Leu Ile Ala Arg 
785                 790                 795                 800 


Asp Thr Pro Pro Pro Trp Glu Gly Phe Arg Asp Asp Leu Arg Val Arg 
                805                 810                 815     


Leu Asp Arg Ile Ile Val Ser His Arg Ala Asp His Gly Arg Ile Asp 
            820                 825                 830         


His Ala Ala Arg Lys Gln Gly Arg Asp Ser Thr Ala Gly Gln Leu His 
        835                 840                 845             


Gln Glu Thr Ala Tyr Ser Ile Val Asp Asp Ile His Val Ala Ser Arg 
    850                 855                 860                 


Thr Asp Leu Leu Ser Leu Lys Pro Ala Gln Leu Leu Asp Glu Pro Gly 
865                 870                 875                 880 


Arg Ser Gly Gln Val Arg Asp Pro Gln Leu Arg Lys Ala Leu Arg Val 
                885                 890                 895     


Ala Thr Gly Gly Lys Thr Gly Lys Asp Phe Glu Asn Ala Leu Arg Tyr 
            900                 905                 910         


Phe Ala Ser Lys Pro Gly Pro Tyr Gln Ala Ile Arg Arg Val Arg Ile 
        915                 920                 925             


Ile Lys Pro Leu Gln Ala Gln Ala Arg Val Pro Val Pro Ala Gln Asp 
    930                 935                 940                 


Pro Ile Lys Ala Tyr Gln Gly Gly Ser Asn His Leu Phe Glu Ile Trp 
945                 950                 955                 960 


Arg Leu Pro Asp Gly Glu Ile Glu Ala Gln Val Ile Thr Ser Phe Glu 
                965                 970                 975     


Ala His Thr Leu Glu Gly Glu Lys Arg Pro His Pro Ala Ala Lys Arg 
            980                 985                 990         


Leu Leu Arg Val His Lys Gly Asp  Met Val Ala Leu Glu  Arg Asp Gly 
        995                 1000                 1005             


Arg Arg  Val Val Gly His Val  Gln Lys Met Asp Ile  Ala Asn Gly 
    1010                 1015                 1020             


Leu Phe  Ile Val Pro His Asn  Glu Ala Asn Ala Asp  Thr Arg Asn 
    1025                 1030                 1035             


Asn Asp  Lys Ser Asp Pro Phe  Lys Trp Ile Gln Ile  Gly Ala Arg 
    1040                 1045                 1050             


Pro Ala  Ile Ala Ser Gly Ile  Arg Arg Val Ser Val  Asp Glu Ile 
    1055                 1060                 1065             


Gly Arg  Leu Arg Asp Gly Gly  Thr Arg Pro Ile 
    1070                 1075                 


<210>  753
<211>  1168
<212>  PRT
<213>  Azospirillum sp- B510

<400>  753

Met Ala Arg Pro Ala Phe Arg Ala Pro Arg Arg Glu His Val Asn Gly 
1               5                   10                  15      


Trp Thr Pro Asp Pro His Arg Ile Ser Lys Pro Phe Phe Ile Leu Val 
            20                  25                  30          


Ser Trp His Leu Leu Ser Arg Val Val Ile Asp Ser Ser Ser Gly Cys 
        35                  40                  45              


Phe Pro Gly Thr Ser Arg Asp His Thr Asp Lys Phe Ala Glu Trp Glu 
    50                  55                  60                  


Cys Ala Val Gln Pro Tyr Arg Leu Ser Phe Asp Leu Gly Thr Asn Ser 
65                  70                  75                  80  


Ile Gly Trp Gly Leu Leu Asn Leu Asp Arg Gln Gly Lys Pro Arg Glu 
                85                  90                  95      


Ile Arg Ala Leu Gly Ser Arg Ile Phe Ser Asp Gly Arg Asp Pro Gln 
            100                 105                 110         


Asp Lys Ala Ser Leu Ala Val Ala Arg Arg Leu Ala Arg Gln Met Arg 
        115                 120                 125             


Arg Arg Arg Asp Arg Tyr Leu Thr Arg Arg Thr Arg Leu Met Gly Ala 
    130                 135                 140                 


Leu Val Arg Phe Gly Leu Met Pro Ala Asp Pro Ala Ala Arg Lys Arg 
145                 150                 155                 160 


Leu Glu Val Ala Val Asp Pro Tyr Leu Ala Arg Glu Arg Ala Thr Arg 
                165                 170                 175     


Glu Arg Leu Glu Pro Phe Glu Ile Gly Arg Ala Leu Phe His Leu Asn 
            180                 185                 190         


Gln Arg Arg Gly Tyr Lys Pro Val Arg Thr Ala Thr Lys Pro Asp Glu 
        195                 200                 205             


Glu Ala Gly Lys Val Lys Glu Ala Val Glu Arg Leu Glu Ala Ala Ile 
    210                 215                 220                 


Ala Ala Ala Gly Ala Pro Thr Leu Gly Ala Trp Phe Ala Trp Arg Lys 
225                 230                 235                 240 


Thr Arg Gly Glu Thr Leu Arg Ala Arg Leu Ala Gly Lys Gly Lys Glu 
                245                 250                 255     


Ala Ala Tyr Pro Phe Tyr Pro Ala Arg Arg Met Leu Glu Ala Glu Phe 
            260                 265                 270         


Asp Thr Leu Trp Ala Glu Gln Ala Arg His His Pro Asp Leu Leu Thr 
        275                 280                 285             


Ala Glu Ala Arg Glu Ile Leu Arg His Arg Ile Phe His Gln Arg Pro 
    290                 295                 300                 


Leu Lys Pro Pro Pro Val Gly Arg Cys Thr Leu Tyr Pro Asp Asp Gly 
305                 310                 315                 320 


Arg Ala Pro Arg Ala Leu Pro Ser Ala Gln Arg Leu Arg Leu Phe Gln 
                325                 330                 335     


Glu Leu Ala Ser Leu Arg Val Ile His Leu Asp Leu Ser Glu Arg Pro 
            340                 345                 350         


Leu Thr Pro Ala Glu Arg Asp Arg Ile Val Ala Phe Val Gln Gly Arg 
        355                 360                 365             


Pro Pro Lys Ala Gly Arg Lys Pro Gly Lys Val Gln Lys Ser Val Pro 
    370                 375                 380                 


Phe Glu Lys Leu Arg Gly Leu Leu Glu Leu Pro Pro Gly Thr Gly Phe 
385                 390                 395                 400 


Ser Leu Glu Ser Asp Lys Arg Pro Glu Leu Leu Gly Asp Glu Thr Gly 
                405                 410                 415     


Ala Arg Ile Ala Pro Ala Phe Gly Pro Gly Trp Thr Ala Leu Pro Leu 
            420                 425                 430         


Glu Glu Gln Asp Ala Leu Val Glu Leu Leu Leu Thr Glu Ala Glu Pro 
        435                 440                 445             


Glu Arg Ala Ile Ala Ala Leu Thr Ala Arg Trp Ala Leu Asp Glu Ala 
    450                 455                 460                 


Thr Ala Ala Lys Leu Ala Gly Ala Thr Leu Pro Asp Phe His Gly Arg 
465                 470                 475                 480 


Tyr Gly Arg Arg Ala Val Ala Glu Leu Leu Pro Val Leu Glu Arg Glu 
                485                 490                 495     


Thr Arg Gly Asp Pro Asp Gly Arg Val Arg Pro Ile Arg Leu Asp Glu 
            500                 505                 510         


Ala Val Lys Leu Leu Arg Gly Gly Lys Asp His Ser Asp Phe Ser Arg 
        515                 520                 525             


Glu Gly Ala Leu Leu Asp Ala Leu Pro Tyr Tyr Gly Ala Val Leu Glu 
    530                 535                 540                 


Arg His Val Ala Phe Gly Thr Gly Asn Pro Ala Asp Pro Glu Glu Lys 
545                 550                 555                 560 


Arg Val Gly Arg Val Ala Asn Pro Thr Val His Ile Ala Leu Asn Gln 
                565                 570                 575     


Leu Arg His Leu Val Asn Ala Ile Leu Ala Arg His Gly Arg Pro Glu 
            580                 585                 590         


Glu Ile Val Ile Glu Leu Ala Arg Asp Leu Lys Arg Ser Ala Glu Asp 
        595                 600                 605             


Arg Arg Arg Glu Asp Lys Arg Gln Ala Asp Asn Gln Lys Arg Asn Glu 
    610                 615                 620                 


Glu Arg Lys Arg Leu Ile Leu Ser Leu Gly Glu Arg Pro Thr Pro Arg 
625                 630                 635                 640 


Asn Leu Leu Lys Leu Arg Leu Trp Glu Glu Gln Gly Pro Val Glu Asn 
                645                 650                 655     


Arg Arg Cys Pro Tyr Ser Gly Glu Thr Ile Ser Met Arg Met Leu Leu 
            660                 665                 670         


Ser Glu Gln Val Asp Ile Asp His Ile Leu Pro Phe Ser Val Ser Leu 
        675                 680                 685             


Asp Asp Ser Ala Ala Asn Lys Val Val Cys Leu Arg Glu Ala Asn Arg 
    690                 695                 700                 


Ile Lys Arg Asn Arg Ser Pro Trp Glu Ala Phe Gly His Asp Ser Glu 
705                 710                 715                 720 


Arg Trp Ala Gly Ile Leu Ala Arg Ala Glu Ala Leu Pro Lys Asn Lys 
                725                 730                 735     


Arg Trp Arg Phe Ala Pro Asp Ala Leu Glu Lys Leu Glu Gly Glu Gly 
            740                 745                 750         


Gly Leu Arg Ala Arg His Leu Asn Asp Thr Arg His Leu Ser Arg Leu 
        755                 760                 765             


Ala Val Glu Tyr Leu Arg Cys Val Cys Pro Lys Val Arg Val Ser Pro 
    770                 775                 780                 


Gly Arg Leu Thr Ala Leu Leu Arg Arg Arg Trp Gly Ile Asp Ala Ile 
785                 790                 795                 800 


Leu Ala Glu Ala Asp Gly Pro Pro Pro Glu Val Pro Ala Glu Thr Leu 
                805                 810                 815     


Asp Pro Ser Pro Ala Glu Lys Asn Arg Ala Asp His Arg His His Ala 
            820                 825                 830         


Leu Asp Ala Val Val Ile Gly Cys Ile Asp Arg Ser Met Val Gln Arg 
        835                 840                 845             


Val Gln Leu Ala Ala Ala Ser Ala Glu Arg Glu Ala Ala Ala Arg Glu 
    850                 855                 860                 


Asp Asn Ile Arg Arg Val Leu Glu Gly Phe Lys Glu Glu Pro Trp Asp 
865                 870                 875                 880 


Gly Phe Arg Ala Glu Leu Glu Arg Arg Ala Arg Thr Ile Val Val Ser 
                885                 890                 895     


His Arg Pro Glu His Gly Ile Gly Gly Ala Leu His Lys Glu Thr Ala 
            900                 905                 910         


Tyr Gly Pro Val Asp Pro Pro Glu Glu Gly Phe Asn Leu Val Val Arg 
        915                 920                 925             


Lys Pro Ile Asp Gly Leu Ser Lys Asp Glu Ile Asn Ser Val Arg Asp 
    930                 935                 940                 


Pro Arg Leu Arg Arg Ala Leu Ile Asp Arg Leu Ala Ile Arg Arg Arg 
945                 950                 955                 960 


Asp Ala Asn Asp Pro Ala Thr Ala Leu Ala Lys Ala Ala Glu Asp Leu 
                965                 970                 975     


Ala Ala Gln Pro Ala Ser Arg Gly Ile Arg Arg Val Arg Val Leu Lys 
            980                 985                 990         


Lys Glu Ser Asn Pro Ile Arg Val  Glu His Gly Gly Asn  Pro Ser Gly 
        995                 1000                 1005             


Pro Arg  Ser Gly Gly Pro Phe  His Lys Leu Leu Leu  Ala Gly Glu 
    1010                 1015                 1020             


Val His  His Val Asp Val Ala  Leu Arg Ala Asp Gly  Arg Arg Trp 
    1025                 1030                 1035             


Val Gly  His Trp Val Thr Leu  Phe Glu Ala His Gly  Gly Arg Gly 
    1040                 1045                 1050             


Ala Asp  Gly Ala Ala Ala Pro  Pro Arg Leu Gly Asp  Gly Glu Arg 
    1055                 1060                 1065             


Phe Leu  Met Arg Leu His Lys  Gly Asp Cys Leu Lys  Leu Glu His 
    1070                 1075                 1080             


Lys Gly  Arg Val Arg Val Met  Gln Val Val Lys Leu  Glu Pro Ser 
    1085                 1090                 1095             


Ser Asn  Ser Val Val Val Val  Glu Pro His Gln Val  Lys Thr Asp 
    1100                 1105                 1110             


Arg Ser  Lys His Val Lys Ile  Ser Cys Asp Gln Leu  Arg Ala Arg 
    1115                 1120                 1125             


Gly Ala  Arg Arg Val Thr Val  Asp Pro Leu Gly Arg  Val Arg Val 
    1130                 1135                 1140             


His Ala  Pro Gly Ala Arg Val  Gly Ile Gly Gly Asp  Ala Gly Arg 
    1145                 1150                 1155             


Thr Ala  Met Glu Pro Ala Glu  Asp Ile Ser 
    1160                 1165             


<210>  754
<211>  1166
<212>  PRT
<213>  Nitrobacter hamburgensis X14

<400>  754

Met His Val Glu Ile Asp Phe Pro His Phe Ser Arg Gly Asp Ser His 
1               5                   10                  15      


Leu Ala Met Asn Lys Asn Glu Ile Leu Arg Gly Ser Ser Val Leu Tyr 
            20                  25                  30          


Arg Leu Gly Leu Asp Leu Gly Ser Asn Ser Leu Gly Trp Phe Val Thr 
        35                  40                  45              


His Leu Glu Lys Arg Gly Asp Arg His Glu Pro Val Ala Leu Gly Pro 
    50                  55                  60                  


Gly Gly Val Arg Ile Phe Pro Asp Gly Arg Asp Pro Gln Ser Gly Thr 
65                  70                  75                  80  


Ser Asn Ala Val Asp Arg Arg Met Ala Arg Gly Ala Arg Lys Arg Arg 
                85                  90                  95      


Asp Arg Phe Val Glu Arg Arg Lys Glu Leu Ile Ala Ala Leu Ile Lys 
            100                 105                 110         


Tyr Asn Leu Leu Pro Asp Asp Ala Arg Glu Arg Arg Ala Leu Glu Val 
        115                 120                 125             


Leu Asp Pro Tyr Ala Leu Arg Lys Thr Ala Leu Thr Asp Thr Leu Pro 
    130                 135                 140                 


Ala His His Val Gly Arg Ala Leu Phe His Leu Asn Gln Arg Arg Gly 
145                 150                 155                 160 


Phe Gln Ser Asn Arg Lys Thr Asp Ser Lys Gln Ser Glu Asp Gly Ala 
                165                 170                 175     


Ile Lys Gln Ala Ala Ser Arg Leu Ala Thr Asp Lys Gly Asn Glu Thr 
            180                 185                 190         


Leu Gly Val Phe Phe Ala Asp Met His Leu Arg Lys Ser Tyr Glu Asp 
        195                 200                 205             


Arg Gln Thr Ala Ile Arg Ala Glu Leu Val Arg Leu Gly Lys Asp His 
    210                 215                 220                 


Leu Thr Gly Asn Ala Arg Lys Lys Ile Trp Ala Lys Val Arg Lys Arg 
225                 230                 235                 240 


Leu Phe Gly Asp Glu Val Leu Pro Arg Ala Asp Ala Pro His Gly Val 
                245                 250                 255     


Arg Ala Arg Ala Thr Ile Thr Gly Thr Lys Ala Ser Tyr Asp Tyr Tyr 
            260                 265                 270         


Pro Thr Arg Asp Met Leu Arg Asp Glu Phe Asn Ala Ile Trp Ala Gly 
        275                 280                 285             


Gln Ser Ala His His Ala Thr Ile Thr Asp Glu Ala Arg Thr Glu Ile 
    290                 295                 300                 


Glu His Ile Ile Phe Tyr Gln Arg Pro Leu Lys Pro Ala Ile Val Gly 
305                 310                 315                 320 


Lys Cys Thr Leu Asp Pro Ala Thr Arg Pro Phe Lys Glu Asp Pro Glu 
                325                 330                 335     


Gly Tyr Arg Ala Pro Trp Ser His Pro Leu Ala Gln Arg Phe Arg Ile 
            340                 345                 350         


Leu Ser Glu Ala Arg Asn Leu Glu Ile Arg Asp Thr Gly Lys Gly Ser 
        355                 360                 365             


Arg Arg Leu Thr Lys Glu Gln Ser Asp Leu Val Val Ala Ala Leu Leu 
    370                 375                 380                 


Ala Asn Arg Glu Val Lys Phe Asp Lys Leu Arg Thr Leu Leu Lys Leu 
385                 390                 395                 400 


Pro Ala Glu Ala Arg Phe Asn Leu Glu Ser Asp Arg Arg Ala Ala Leu 
                405                 410                 415     


Asp Gly Asp Gln Thr Ala Ala Arg Leu Ser Asp Lys Lys Gly Phe Asn 
            420                 425                 430         


Lys Ala Trp Arg Gly Phe Pro Pro Glu Arg Gln Ile Ala Ile Val Ala 
        435                 440                 445             


Arg Leu Glu Glu Thr Glu Asp Glu Asn Glu Leu Ile Ala Trp Leu Glu 
    450                 455                 460                 


Lys Glu Cys Ala Leu Asp Gly Ala Ala Ala Ala Arg Val Ala Asn Thr 
465                 470                 475                 480 


Thr Leu Pro Asp Gly His Cys Arg Leu Gly Leu Arg Ala Ile Lys Lys 
                485                 490                 495     


Ile Val Pro Ile Met Gln Asp Gly Leu Asp Glu Asp Gly Val Ala Gly 
            500                 505                 510         


Ala Gly Tyr His Ile Ala Ala Lys Arg Ala Gly Tyr Asp His Ala Lys 
        515                 520                 525             


Leu Pro Thr Gly Glu Gln Leu Gly Arg Leu Pro Tyr Tyr Gly Gln Trp 
    530                 535                 540                 


Leu Gln Asp Ala Val Val Gly Ser Gly Asp Ala Arg Asp Gln Lys Glu 
545                 550                 555                 560 


Lys Gln Tyr Gly Gln Phe Pro Asn Pro Thr Val His Ile Gly Leu Gly 
                565                 570                 575     


Gln Leu Arg Arg Val Val Asn Asp Leu Ile Asp Lys Tyr Gly Pro Pro 
            580                 585                 590         


Thr Glu Ile Ser Ile Glu Phe Thr Arg Ala Leu Lys Leu Ser Glu Gln 
        595                 600                 605             


Gln Lys Ala Glu Arg Gln Arg Glu Gln Arg Arg Asn Gln Asp Lys Asn 
    610                 615                 620                 


Lys Ala Arg Ala Glu Glu Leu Ala Lys Phe Gly Arg Pro Ala Asn Pro 
625                 630                 635                 640 


Arg Asn Leu Leu Lys Met Arg Leu Trp Glu Glu Leu Ala His Asp Pro 
                645                 650                 655     


Leu Asp Arg Lys Cys Val Tyr Thr Gly Glu Gln Ile Ser Ile Glu Arg 
            660                 665                 670         


Leu Leu Ser Asp Glu Val Asp Ile Asp His Ile Leu Pro Val Ala Met 
        675                 680                 685             


Thr Leu Asp Asp Ser Pro Ala Asn Lys Ile Ile Cys Met Arg Tyr Ala 
    690                 695                 700                 


Asn Arg His Lys Arg Lys Gln Thr Pro Ser Glu Ala Phe Gly Ser Ser 
705                 710                 715                 720 


Pro Thr Leu Gln Gly His Arg Tyr Asn Trp Asp Asp Ile Ala Ala Arg 
                725                 730                 735     


Ala Thr Gly Leu Pro Arg Asn Lys Arg Trp Arg Phe Asp Ala Asn Ala 
            740                 745                 750         


Arg Glu Glu Phe Asp Lys Arg Gly Gly Phe Leu Ala Arg Gln Leu Asn 
        755                 760                 765             


Glu Thr Gly Trp Leu Ala Arg Leu Ala Lys Gln Tyr Leu Gly Ala Val 
    770                 775                 780                 


Thr Asp Pro Asn Gln Ile Trp Val Val Pro Gly Arg Leu Thr Ser Met 
785                 790                 795                 800 


Leu Arg Gly Lys Trp Gly Leu Asn Gly Leu Leu Pro Ser Asp Asn Tyr 
                805                 810                 815     


Ala Gly Val Gln Asp Lys Ala Glu Glu Phe Leu Ala Ser Thr Asp Asp 
            820                 825                 830         


Met Glu Phe Ser Gly Val Lys Asn Arg Ala Asp His Arg His His Ala 
        835                 840                 845             


Ile Asp Gly Leu Val Thr Ala Leu Thr Asp Arg Ser Leu Leu Trp Lys 
    850                 855                 860                 


Met Ala Asn Ala Tyr Asp Glu Glu His Glu Lys Phe Val Ile Glu Pro 
865                 870                 875                 880 


Pro Trp Pro Thr Met Arg Asp Asp Leu Lys Ala Ala Leu Glu Lys Met 
                885                 890                 895     


Val Val Ser His Lys Pro Asp His Gly Ile Glu Gly Lys Leu His Glu 
            900                 905                 910         


Asp Ser Ala Tyr Gly Phe Val Lys Pro Leu Asp Ala Thr Gly Leu Lys 
        915                 920                 925             


Glu Glu Glu Ala Gly Asn Leu Val Tyr Arg Lys Ala Ile Glu Ser Leu 
    930                 935                 940                 


Asn Glu Asn Glu Val Asp Arg Ile Arg Asp Ile Gln Leu Arg Thr Ile 
945                 950                 955                 960 


Val Arg Asp His Val Asn Val Glu Lys Thr Lys Gly Val Ala Leu Ala 
                965                 970                 975     


Asp Ala Leu Arg Gln Leu Gln Ala Pro Ser Asp Asp Tyr Pro Gln Phe 
            980                 985                 990         


Lys His Gly Leu Arg His Val Arg  Ile Leu Lys Lys Glu  Lys Gly Asp 
        995                 1000                 1005             


Tyr Leu  Val Pro Ile Ala Asn  Arg Ala Ser Gly Val  Ala Tyr Lys 
    1010                 1015                 1020             


Ala Tyr  Ser Ala Gly Glu Asn  Phe Cys Val Glu Val  Phe Glu Thr 
    1025                 1030                 1035             


Ala Gly  Gly Lys Trp Asp Gly  Glu Ala Val Arg Arg  Phe Asp Ala 
    1040                 1045                 1050             


Asn Lys  Lys Asn Ala Gly Pro  Lys Ile Ala His Ala  Pro Gln Trp 
    1055                 1060                 1065             


Arg Asp  Ala Asn Glu Gly Ala  Lys Leu Val Met Arg  Ile His Lys 
    1070                 1075                 1080             


Gly Asp  Leu Ile Arg Leu Asp  His Glu Gly Arg Ala  Arg Ile Met 
    1085                 1090                 1095             


Val Val  His Arg Leu Asp Ala  Ala Ala Gly Arg Phe  Lys Leu Ala 
    1100                 1105                 1110             


Asp His  Asn Glu Thr Gly Asn  Leu Asp Lys Arg His  Ala Thr Asn 
    1115                 1120                 1125             


Asn Asp  Ile Asp Pro Phe Arg  Trp Leu Met Ala Ser  Tyr Asn Thr 
    1130                 1135                 1140             


Leu Lys  Lys Leu Ala Ala Val  Pro Val Arg Val Asp  Glu Leu Gly 
    1145                 1150                 1155             


Arg Val  Trp Arg Val Met Pro  Asn 
    1160                 1165     


<210>  755
<211>  1064
<212>  PRT
<213>  Bradyrhizobium sp- BTAi1

<400>  755

Met Lys Arg Thr Ser Leu Arg Ala Tyr Arg Leu Gly Val Asp Leu Gly 
1               5                   10                  15      


Ala Asn Ser Leu Gly Trp Phe Val Val Trp Leu Asp Asp His Gly Gln 
            20                  25                  30          


Pro Glu Gly Leu Gly Pro Gly Gly Val Arg Ile Phe Pro Asp Gly Arg 
        35                  40                  45              


Asn Pro Gln Ser Lys Gln Ser Asn Ala Ala Gly Arg Arg Leu Ala Arg 
    50                  55                  60                  


Ser Ala Arg Arg Arg Arg Asp Arg Tyr Leu Gln Arg Arg Gly Lys Leu 
65                  70                  75                  80  


Met Gly Leu Leu Val Lys His Gly Leu Met Pro Ala Asp Glu Pro Ala 
                85                  90                  95      


Arg Lys Arg Leu Glu Cys Leu Asp Pro Tyr Gly Leu Arg Ala Lys Ala 
            100                 105                 110         


Leu Asp Glu Val Leu Pro Leu His His Val Gly Arg Ala Leu Phe His 
        115                 120                 125             


Leu Asn Gln Arg Arg Gly Leu Phe Ala Asn Arg Ala Ile Glu Gln Gly 
    130                 135                 140                 


Asp Lys Asp Ala Ser Ala Ile Lys Ala Ala Ala Gly Arg Leu Gln Thr 
145                 150                 155                 160 


Ser Met Gln Ala Cys Gly Ala Arg Thr Leu Gly Glu Phe Leu Asn Arg 
                165                 170                 175     


Arg His Gln Leu Arg Ala Thr Val Arg Ala Arg Ser Pro Val Gly Gly 
            180                 185                 190         


Asp Val Gln Ala Arg Tyr Glu Phe Tyr Pro Thr Arg Ala Met Val Asp 
        195                 200                 205             


Ala Glu Phe Glu Ala Ile Trp Ala Ala Gln Ala Pro His His Pro Thr 
    210                 215                 220                 


Met Thr Ala Glu Ala His Asp Thr Ile Arg Glu Ala Ile Phe Ser Gln 
225                 230                 235                 240 


Arg Ala Met Lys Arg Pro Ser Ile Gly Lys Cys Ser Leu Asp Pro Ala 
                245                 250                 255     


Thr Ser Gln Asp Asp Val Asp Gly Phe Arg Cys Ala Trp Ser His Pro 
            260                 265                 270         


Leu Ala Gln Arg Phe Arg Ile Trp Gln Asp Val Arg Asn Leu Ala Val 
        275                 280                 285             


Val Glu Thr Gly Pro Thr Ser Ser Arg Leu Gly Lys Glu Asp Gln Asp 
    290                 295                 300                 


Lys Val Ala Arg Ala Leu Leu Gln Thr Asp Gln Leu Ser Phe Asp Glu 
305                 310                 315                 320 


Ile Arg Gly Leu Leu Gly Leu Pro Ser Asp Ala Arg Phe Asn Leu Glu 
                325                 330                 335     


Ser Asp Arg Arg Asp His Leu Lys Gly Asp Ala Thr Gly Ala Ile Leu 
            340                 345                 350         


Ser Ala Arg Arg His Phe Gly Pro Ala Trp His Asp Arg Ser Leu Asp 
        355                 360                 365             


Arg Gln Ile Asp Ile Val Ala Leu Leu Glu Ser Ala Leu Asp Glu Ala 
    370                 375                 380                 


Ala Ile Ile Ala Ser Leu Gly Thr Thr His Ser Leu Asp Glu Ala Ala 
385                 390                 395                 400 


Ala Gln Arg Ala Leu Ser Ala Leu Leu Pro Asp Gly Tyr Cys Arg Leu 
                405                 410                 415     


Gly Leu Arg Ala Ile Lys Arg Val Leu Pro Leu Met Glu Ala Gly Arg 
            420                 425                 430         


Thr Tyr Ala Glu Ala Ala Ser Ala Ala Gly Tyr Asp His Ala Leu Leu 
        435                 440                 445             


Pro Gly Gly Lys Leu Ser Pro Thr Gly Tyr Leu Pro Tyr Tyr Gly Gln 
    450                 455                 460                 


Trp Leu Gln Asn Asp Val Val Gly Ser Asp Asp Glu Arg Asp Thr Asn 
465                 470                 475                 480 


Glu Arg Arg Trp Gly Arg Leu Pro Asn Pro Thr Val His Ile Gly Ile 
                485                 490                 495     


Gly Gln Leu Arg Arg Val Val Asn Glu Leu Ile Arg Trp His Gly Pro 
            500                 505                 510         


Pro Ala Glu Ile Thr Val Glu Leu Thr Arg Asp Leu Lys Leu Ser Pro 
        515                 520                 525             


Arg Arg Leu Ala Glu Leu Glu Arg Glu Gln Ala Glu Asn Gln Arg Lys 
    530                 535                 540                 


Asn Asp Lys Arg Thr Ser Leu Leu Arg Lys Leu Gly Leu Pro Ala Ser 
545                 550                 555                 560 


Thr His Asn Leu Leu Lys Leu Arg Leu Trp Asp Glu Gln Gly Asp Val 
                565                 570                 575     


Ala Ser Glu Cys Pro Tyr Thr Gly Glu Ala Ile Gly Leu Glu Arg Leu 
            580                 585                 590         


Val Ser Asp Asp Val Asp Ile Asp His Leu Ile Pro Phe Ser Ile Ser 
        595                 600                 605             


Trp Asp Asp Ser Ala Ala Asn Lys Val Val Cys Met Arg Tyr Ala Asn 
    610                 615                 620                 


Arg Glu Lys Gly Asn Arg Thr Pro Phe Glu Ala Phe Gly His Arg Gln 
625                 630                 635                 640 


Gly Arg Pro Tyr Asp Trp Ala Asp Ile Ala Glu Arg Ala Ala Arg Leu 
                645                 650                 655     


Pro Arg Gly Lys Arg Trp Arg Phe Gly Pro Gly Ala Arg Ala Gln Phe 
            660                 665                 670         


Glu Glu Leu Gly Asp Phe Gln Ala Arg Leu Leu Asn Glu Thr Ser Trp 
        675                 680                 685             


Leu Ala Arg Val Ala Lys Gln Tyr Leu Ala Ala Val Thr His Pro His 
    690                 695                 700                 


Arg Ile His Val Leu Pro Gly Arg Leu Thr Ala Leu Leu Arg Ala Thr 
705                 710                 715                 720 


Trp Glu Leu Asn Asp Leu Leu Pro Gly Ser Asp Asp Arg Ala Ala Lys 
                725                 730                 735     


Ser Arg Lys Asp His Arg His His Ala Ile Asp Ala Leu Val Ala Ala 
            740                 745                 750         


Leu Thr Asp Gln Ala Leu Leu Arg Arg Met Ala Asn Ala His Asp Asp 
        755                 760                 765             


Thr Arg Arg Lys Ile Glu Val Leu Leu Pro Trp Pro Thr Phe Arg Ile 
    770                 775                 780                 


Asp Leu Glu Thr Arg Leu Lys Ala Met Leu Val Ser His Lys Pro Asp 
785                 790                 795                 800 


His Gly Leu Gln Ala Arg Leu His Glu Asp Thr Ala Tyr Gly Thr Val 
                805                 810                 815     


Glu His Pro Glu Thr Glu Asp Gly Ala Asn Leu Val Tyr Arg Lys Thr 
            820                 825                 830         


Phe Val Asp Ile Ser Glu Lys Glu Ile Asp Arg Ile Arg Asp Arg Arg 
        835                 840                 845             


Leu Arg Asp Leu Val Arg Ala His Val Ala Gly Glu Arg Gln Gln Gly 
    850                 855                 860                 


Lys Thr Leu Lys Ala Ala Val Leu Ser Phe Ala Gln Arg Arg Asp Ile 
865                 870                 875                 880 


Ala Gly His Pro Asn Gly Ile Arg His Val Arg Leu Thr Lys Ser Ile 
                885                 890                 895     


Lys Pro Asp Tyr Leu Val Pro Ile Arg Asp Lys Ala Gly Arg Ile Tyr 
            900                 905                 910         


Lys Ser Tyr Asn Ala Gly Glu Asn Ala Phe Val Asp Ile Leu Gln Ala 
        915                 920                 925             


Glu Ser Gly Arg Trp Ile Ala Arg Ala Thr Thr Val Phe Gln Ala Asn 
    930                 935                 940                 


Gln Ala Asn Glu Ser His Asp Ala Pro Ala Ala Gln Pro Ile Met Arg 
945                 950                 955                 960 


Val Phe Lys Gly Asp Met Leu Arg Ile Asp His Ala Gly Ala Glu Lys 
                965                 970                 975     


Phe Val Lys Ile Val Arg Leu Ser Pro Ser Asn Asn Leu Leu Tyr Leu 
            980                 985                 990         


Val Glu His His Gln Ala Gly Val  Phe Gln Thr Arg His  Asp Asp Pro 
        995                 1000                 1005             


Glu Asp  Ser Phe Arg Trp Leu  Phe Ala Ser Phe Asp  Lys Leu Arg 
    1010                 1015                 1020             


Glu Trp  Asn Ala Glu Leu Val  Arg Ile Asp Thr Leu  Gly Gln Pro 
    1025                 1030                 1035             


Trp Arg  Arg Lys Arg Gly Leu  Glu Thr Gly Ser Glu  Asp Ala Thr 
    1040                 1045                 1050             


Arg Ile  Gly Trp Thr Arg Pro  Lys Lys Trp Pro 
    1055                 1060                 


<210>  756
<211>  1059
<212>  PRT
<213>  Wolinella succinogenes DSM 1740

<400>  756

Met Ile Glu Arg Ile Leu Gly Val Asp Leu Gly Ile Ser Ser Leu Gly 
1               5                   10                  15      


Trp Ala Ile Val Glu Tyr Asp Lys Asp Asp Glu Ala Ala Asn Arg Ile 
            20                  25                  30          


Ile Asp Cys Gly Val Arg Leu Phe Thr Ala Ala Glu Thr Pro Lys Lys 
        35                  40                  45              


Lys Glu Ser Pro Asn Lys Ala Arg Arg Glu Ala Arg Gly Ile Arg Arg 
    50                  55                  60                  


Val Leu Asn Arg Arg Arg Val Arg Met Asn Met Ile Lys Lys Leu Phe 
65                  70                  75                  80  


Leu Arg Ala Gly Leu Ile Gln Asp Val Asp Leu Asp Gly Glu Gly Gly 
                85                  90                  95      


Met Phe Tyr Ser Lys Ala Asn Arg Ala Asp Val Trp Glu Leu Arg His 
            100                 105                 110         


Asp Gly Leu Tyr Arg Leu Leu Lys Gly Asp Glu Leu Ala Arg Val Leu 
        115                 120                 125             


Ile His Ile Ala Lys His Arg Gly Tyr Lys Phe Ile Gly Asp Asp Glu 
    130                 135                 140                 


Ala Asp Glu Glu Ser Gly Lys Val Lys Lys Ala Gly Val Val Leu Arg 
145                 150                 155                 160 


Gln Asn Phe Glu Ala Ala Gly Cys Arg Thr Val Gly Glu Trp Leu Trp 
                165                 170                 175     


Arg Glu Arg Gly Ala Asn Gly Lys Lys Arg Asn Lys His Gly Asp Tyr 
            180                 185                 190         


Glu Ile Ser Ile His Arg Asp Leu Leu Val Glu Glu Val Glu Ala Ile 
        195                 200                 205             


Phe Val Ala Gln Gln Glu Met Arg Ser Thr Ile Ala Thr Asp Ala Leu 
    210                 215                 220                 


Lys Ala Ala Tyr Arg Glu Ile Ala Phe Phe Val Arg Pro Met Gln Arg 
225                 230                 235                 240 


Ile Glu Lys Met Val Gly His Cys Thr Tyr Phe Pro Glu Glu Arg Arg 
                245                 250                 255     


Ala Pro Lys Ser Ala Pro Thr Ala Glu Lys Phe Ile Ala Ile Ser Lys 
            260                 265                 270         


Phe Phe Ser Thr Val Ile Ile Asp Asn Glu Gly Trp Glu Gln Lys Ile 
        275                 280                 285             


Ile Glu Arg Lys Thr Leu Glu Glu Leu Leu Asp Phe Ala Val Ser Arg 
    290                 295                 300                 


Glu Lys Val Glu Phe Arg His Leu Arg Lys Phe Leu Asp Leu Ser Asp 
305                 310                 315                 320 


Asn Glu Ile Phe Lys Gly Leu His Tyr Lys Gly Lys Pro Lys Thr Ala 
                325                 330                 335     


Lys Lys Arg Glu Ala Thr Leu Phe Asp Pro Asn Glu Pro Thr Glu Leu 
            340                 345                 350         


Glu Phe Asp Lys Val Glu Ala Glu Lys Lys Ala Trp Ile Ser Leu Arg 
        355                 360                 365             


Gly Ala Ala Lys Leu Arg Glu Ala Leu Gly Asn Glu Phe Tyr Gly Arg 
    370                 375                 380                 


Phe Val Ala Leu Gly Lys His Ala Asp Glu Ala Thr Lys Ile Leu Thr 
385                 390                 395                 400 


Tyr Tyr Lys Asp Glu Gly Gln Lys Arg Arg Glu Leu Thr Lys Leu Pro 
                405                 410                 415     


Leu Glu Ala Glu Met Val Glu Arg Leu Val Lys Ile Gly Phe Ser Asp 
            420                 425                 430         


Phe Leu Lys Leu Ser Leu Lys Ala Ile Arg Asp Ile Leu Pro Ala Met 
        435                 440                 445             


Glu Ser Gly Ala Arg Tyr Asp Glu Ala Val Leu Met Leu Gly Val Pro 
    450                 455                 460                 


His Lys Glu Lys Ser Ala Ile Leu Pro Pro Leu Asn Lys Thr Asp Ile 
465                 470                 475                 480 


Asp Ile Leu Asn Pro Thr Val Ile Arg Ala Phe Ala Gln Phe Arg Lys 
                485                 490                 495     


Val Ala Asn Ala Leu Val Arg Lys Tyr Gly Ala Phe Asp Arg Val His 
            500                 505                 510         


Phe Glu Leu Ala Arg Glu Ile Asn Thr Lys Gly Glu Ile Glu Asp Ile 
        515                 520                 525             


Lys Glu Ser Gln Arg Lys Asn Glu Lys Glu Arg Lys Glu Ala Ala Asp 
    530                 535                 540                 


Trp Ile Ala Glu Thr Ser Phe Gln Val Pro Leu Thr Arg Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Arg Leu Tyr Ile Gln Gln Asp Gly Arg Cys Ala Tyr Thr 
                565                 570                 575     


Gly Asp Val Ile Glu Leu Glu Arg Leu Phe Asp Glu Gly Tyr Cys Glu 
            580                 585                 590         


Ile Asp His Ile Leu Pro Arg Ser Arg Ser Ala Asp Asp Ser Phe Ala 
        595                 600                 605             


Asn Lys Val Leu Cys Leu Ala Arg Ala Asn Gln Gln Lys Thr Asp Arg 
    610                 615                 620                 


Thr Pro Tyr Glu Trp Phe Gly His Asp Ala Ala Arg Trp Asn Ala Phe 
625                 630                 635                 640 


Glu Thr Arg Thr Ser Ala Pro Ser Asn Arg Val Arg Thr Gly Lys Gly 
                645                 650                 655     


Lys Ile Asp Arg Leu Leu Lys Lys Asn Phe Asp Glu Asn Ser Glu Met 
            660                 665                 670         


Ala Phe Lys Asp Arg Asn Leu Asn Asp Thr Arg Tyr Met Ala Arg Ala 
        675                 680                 685             


Ile Lys Thr Tyr Cys Glu Gln Tyr Trp Val Phe Lys Asn Ser His Thr 
    690                 695                 700                 


Lys Ala Pro Val Gln Val Arg Ser Gly Lys Leu Thr Ser Val Leu Arg 
705                 710                 715                 720 


Tyr Gln Trp Gly Leu Glu Ser Lys Asp Arg Glu Ser His Thr His His 
                725                 730                 735     


Ala Val Asp Ala Ile Ile Ile Ala Phe Ser Thr Gln Gly Met Val Gln 
            740                 745                 750         


Lys Leu Ser Glu Tyr Tyr Arg Phe Lys Glu Thr His Arg Glu Lys Glu 
        755                 760                 765             


Arg Pro Lys Leu Ala Val Pro Leu Ala Asn Phe Arg Asp Ala Val Glu 
    770                 775                 780                 


Glu Ala Thr Arg Ile Glu Asn Thr Glu Thr Val Lys Glu Gly Val Glu 
785                 790                 795                 800 


Val Lys Arg Leu Leu Ile Ser Arg Pro Pro Arg Ala Arg Val Thr Gly 
                805                 810                 815     


Gln Ala His Glu Gln Thr Ala Lys Pro Tyr Pro Arg Ile Lys Gln Val 
            820                 825                 830         


Lys Asn Lys Lys Lys Trp Arg Leu Ala Pro Ile Asp Glu Glu Lys Phe 
        835                 840                 845             


Glu Ser Phe Lys Ala Asp Arg Val Ala Ser Ala Asn Gln Lys Asn Phe 
    850                 855                 860                 


Tyr Glu Thr Ser Thr Ile Pro Arg Val Asp Val Tyr His Lys Lys Gly 
865                 870                 875                 880 


Lys Phe His Leu Val Pro Ile Tyr Leu His Glu Met Val Leu Asn Glu 
                885                 890                 895     


Leu Pro Asn Leu Ser Leu Gly Thr Asn Pro Glu Ala Met Asp Glu Asn 
            900                 905                 910         


Phe Phe Lys Phe Ser Ile Phe Lys Asp Asp Leu Ile Ser Ile Gln Thr 
        915                 920                 925             


Gln Gly Thr Pro Lys Lys Pro Ala Lys Ile Ile Met Gly Tyr Phe Lys 
    930                 935                 940                 


Asn Met His Gly Ala Asn Met Val Leu Ser Ser Ile Asn Asn Ser Pro 
945                 950                 955                 960 


Cys Glu Gly Phe Thr Cys Thr Pro Val Ser Met Asp Lys Lys His Lys 
                965                 970                 975     


Asp Lys Cys Lys Leu Cys Pro Glu Glu Asn Arg Ile Ala Gly Arg Cys 
            980                 985                 990         


Leu Gln Gly Phe Leu Asp Tyr Trp  Ser Gln Glu Gly Leu  Arg Pro Pro 
        995                 1000                 1005             


Arg Lys  Glu Phe Glu Cys Asp  Gln Gly Val Lys Phe  Ala Leu Asp 
    1010                 1015                 1020             


Val Lys  Lys Tyr Gln Ile Asp  Pro Leu Gly Tyr Tyr  Tyr Glu Val 
    1025                 1030                 1035             


Lys Gln  Glu Lys Arg Leu Gly  Thr Ile Pro Gln Met  Arg Ser Ala 
    1040                 1045                 1050             


Lys Lys  Leu Val Lys Lys 
    1055                 


<210>  757
<211>  984
<212>  PRT
<213>  Campylobacter jejuni subsp. jejuni NCTC 11168

<400>  757

Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Val Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Val Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asn Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210>  758
<211>  1024
<212>  PRT
<213>  Helicobacter mustelae 12198

<400>  758

Met Ile Arg Thr Leu Gly Ile Asp Ile Gly Ile Ala Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Ile Glu Gly Glu Tyr Thr Asp Lys Gly Leu Glu Asn Lys Glu 
            20                  25                  30          


Ile Val Ala Ser Gly Val Arg Val Phe Thr Lys Ala Glu Asn Pro Lys 
        35                  40                  45              


Asn Lys Glu Ser Leu Ala Leu Pro Arg Thr Leu Ala Arg Ser Ala Arg 
    50                  55                  60                  


Arg Arg Asn Ala Arg Lys Lys Gly Arg Ile Gln Gln Val Lys His Tyr 
65                  70                  75                  80  


Leu Ser Lys Ala Leu Gly Leu Asp Leu Glu Cys Phe Val Gln Gly Glu 
                85                  90                  95      


Lys Leu Ala Thr Leu Phe Gln Thr Ser Lys Asp Phe Leu Ser Pro Trp 
            100                 105                 110         


Glu Leu Arg Glu Arg Ala Leu Tyr Arg Val Leu Asp Lys Glu Glu Leu 
        115                 120                 125             


Ala Arg Val Ile Leu His Ile Ala Lys Arg Arg Gly Tyr Asp Asp Ile 
    130                 135                 140                 


Thr Tyr Gly Val Glu Asp Asn Asp Ser Gly Lys Ile Lys Lys Ala Ile 
145                 150                 155                 160 


Ala Glu Asn Ser Lys Arg Ile Lys Glu Glu Gln Cys Lys Thr Ile Gly 
                165                 170                 175     


Glu Met Met Tyr Lys Leu Tyr Phe Gln Lys Ser Leu Asn Val Arg Asn 
            180                 185                 190         


Lys Lys Glu Ser Tyr Asn Arg Cys Val Gly Arg Ser Glu Leu Arg Glu 
        195                 200                 205             


Glu Leu Lys Thr Ile Phe Gln Ile Gln Gln Glu Leu Lys Ser Pro Trp 
    210                 215                 220                 


Val Asn Glu Glu Leu Ile Tyr Lys Leu Leu Gly Asn Pro Asp Ala Gln 
225                 230                 235                 240 


Ser Lys Gln Glu Arg Glu Gly Leu Ile Phe Tyr Gln Arg Pro Leu Lys 
                245                 250                 255     


Gly Phe Gly Asp Lys Ile Gly Lys Cys Ser His Ile Lys Lys Gly Glu 
            260                 265                 270         


Asn Ser Pro Tyr Arg Ala Cys Lys His Ala Pro Ser Ala Glu Glu Phe 
        275                 280                 285             


Val Ala Leu Thr Lys Ser Ile Asn Phe Leu Lys Asn Leu Thr Asn Arg 
    290                 295                 300                 


His Gly Leu Cys Phe Ser Gln Glu Asp Met Cys Val Tyr Leu Gly Lys 
305                 310                 315                 320 


Ile Leu Gln Glu Ala Gln Lys Asn Glu Lys Gly Leu Thr Tyr Ser Lys 
                325                 330                 335     


Leu Lys Leu Leu Leu Asp Leu Pro Ser Asp Phe Glu Phe Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ser Gly Lys Asn Pro Glu Lys Ala Val Phe Leu Ser Leu Pro 
        355                 360                 365             


Ser Thr Phe Lys Leu Asn Lys Ile Thr Gln Asp Arg Lys Thr Gln Asp 
    370                 375                 380                 


Lys Ile Ala Asn Ile Leu Gly Ala Asn Lys Asp Trp Glu Ala Ile Leu 
385                 390                 395                 400 


Lys Glu Leu Glu Ser Leu Gln Leu Ser Lys Glu Gln Ile Gln Thr Ile 
                405                 410                 415     


Lys Asp Ala Lys Leu Asn Phe Ser Lys His Ile Asn Leu Ser Leu Glu 
            420                 425                 430         


Ala Leu Tyr His Leu Leu Pro Leu Met Arg Glu Gly Lys Arg Tyr Asp 
        435                 440                 445             


Glu Gly Val Glu Ile Leu Gln Glu Arg Gly Ile Phe Ser Lys Pro Gln 
    450                 455                 460                 


Pro Lys Asn Arg Gln Leu Leu Pro Pro Leu Ser Glu Leu Ala Lys Glu 
465                 470                 475                 480 


Glu Ser Tyr Phe Asp Ile Pro Asn Pro Val Leu Arg Arg Ala Leu Ser 
                485                 490                 495     


Glu Phe Arg Lys Val Val Asn Ala Leu Leu Glu Lys Tyr Gly Gly Phe 
            500                 505                 510         


His Tyr Phe His Ile Glu Leu Thr Arg Asp Val Cys Lys Ala Lys Ser 
        515                 520                 525             


Ala Arg Met Gln Leu Glu Lys Ile Asn Lys Lys Asn Lys Ser Glu Asn 
    530                 535                 540                 


Asp Ala Ala Ser Gln Leu Leu Glu Val Leu Gly Leu Pro Asn Thr Tyr 
545                 550                 555                 560 


Asn Asn Arg Leu Lys Cys Lys Leu Trp Lys Gln Gln Glu Glu Tyr Cys 
                565                 570                 575     


Leu Tyr Ser Gly Glu Lys Ile Thr Ile Asp His Leu Lys Asp Gln Arg 
            580                 585                 590         


Ala Leu Gln Ile Asp His Ala Phe Pro Leu Ser Arg Ser Leu Asp Asp 
        595                 600                 605             


Ser Gln Ser Asn Lys Val Leu Cys Leu Thr Ser Ser Asn Gln Glu Lys 
    610                 615                 620                 


Ser Asn Lys Thr Pro Tyr Glu Trp Leu Gly Ser Asp Glu Lys Lys Trp 
625                 630                 635                 640 


Asp Met Tyr Val Gly Arg Val Tyr Ser Ser Asn Phe Ser Pro Ser Lys 
                645                 650                 655     


Lys Arg Lys Leu Thr Gln Lys Asn Phe Lys Glu Arg Asn Glu Glu Asp 
            660                 665                 670         


Phe Leu Ala Arg Asn Leu Val Asp Thr Gly Tyr Ile Gly Arg Val Thr 
        675                 680                 685             


Lys Glu Tyr Ile Lys His Ser Leu Ser Phe Leu Pro Leu Pro Asp Gly 
    690                 695                 700                 


Lys Lys Glu His Ile Arg Ile Ile Ser Gly Ser Met Thr Ser Thr Met 
705                 710                 715                 720 


Arg Ser Phe Trp Gly Val Gln Glu Lys Asn Arg Asp His His Leu His 
                725                 730                 735     


His Ala Gln Asp Ala Ile Ile Ile Ala Cys Ile Glu Pro Ser Met Ile 
            740                 745                 750         


Gln Lys Tyr Thr Thr Tyr Leu Lys Asp Lys Glu Thr His Arg Leu Lys 
        755                 760                 765             


Ser His Gln Lys Ala Gln Ile Leu Arg Glu Gly Asp His Lys Leu Ser 
    770                 775                 780                 


Leu Arg Trp Pro Met Ser Asn Phe Lys Asp Lys Ile Gln Glu Ser Ile 
785                 790                 795                 800 


Gln Asn Ile Ile Pro Ser His His Val Ser His Lys Val Thr Gly Glu 
                805                 810                 815     


Leu His Gln Glu Thr Val Arg Thr Lys Glu Phe Tyr Tyr Gln Ala Phe 
            820                 825                 830         


Gly Gly Glu Glu Gly Val Lys Lys Ala Leu Lys Phe Gly Lys Ile Arg 
        835                 840                 845             


Glu Ile Asn Gln Gly Ile Val Asp Asn Gly Ala Met Val Arg Val Asp 
    850                 855                 860                 


Ile Phe Lys Ser Lys Asp Lys Gly Lys Phe Tyr Ala Val Pro Ile Tyr 
865                 870                 875                 880 


Thr Tyr Asp Phe Ala Ile Gly Lys Leu Pro Asn Lys Ala Ile Val Gln 
                885                 890                 895     


Gly Lys Lys Asn Gly Ile Ile Lys Asp Trp Leu Glu Met Asp Glu Asn 
            900                 905                 910         


Tyr Glu Phe Cys Phe Ser Leu Phe Lys Asn Asp Cys Ile Lys Ile Gln 
        915                 920                 925             


Thr Lys Glu Met Gln Glu Ala Val Leu Ala Ile Tyr Lys Ser Thr Asn 
    930                 935                 940                 


Ser Ala Lys Ala Thr Ile Glu Leu Glu His Leu Ser Lys Tyr Ala Leu 
945                 950                 955                 960 


Lys Asn Glu Asp Glu Glu Lys Met Phe Thr Asp Thr Asp Lys Glu Lys 
                965                 970                 975     


Asn Lys Thr Met Thr Arg Glu Ser Cys Gly Ile Gln Gly Leu Lys Val 
            980                 985                 990         


Phe Gln Lys Val Lys Leu Ser Val  Leu Gly Glu Val Leu  Glu His Lys 
        995                 1000                 1005             


Pro Arg  Asn Arg Gln Asn Ile  Ala Leu Lys Thr Thr  Pro Lys His 
    1010                 1015                 1020             


Val 
    


<210>  759
<211>  1069
<212>  PRT
<213>  Bacillus cereus Rock1-15

<400>  759

Met Asn Tyr Asp Ile Gly Leu Arg Ile Gly Ile Thr Ser Cys Gly Trp 
1               5                   10                  15      


Ser Ile Ile Asn Lys Asp Leu Glu Arg Ile Glu Asp Leu Gly Val Arg 
            20                  25                  30          


Val Phe Glu Lys Ala Glu Asn Pro Asp Gly Thr Ala Ser Ala Ala Pro 
        35                  40                  45              


Arg Arg Glu Ala Arg Lys Ser Arg Arg Lys His Arg Arg Lys Lys His 
    50                  55                  60                  


Arg Ile Glu Arg Ile Lys Arg Leu Ile Val Gln His Asp Leu Leu Ser 
65                  70                  75                  80  


Lys Lys Glu Leu Asp Ser Leu Tyr Leu Ser Pro Phe Asn Ile Asp Val 
                85                  90                  95      


Trp Asn Leu Gln Val Glu Ala Leu Glu Arg Lys Leu Asp Asn Arg Glu 
            100                 105                 110         


Phe Ala Arg Val Leu Ile His Leu Val Gln Arg Arg Gly Phe Gln Thr 
        115                 120                 125             


Ile Arg Lys Ser Val Glu Ile Gln Glu Glu Gly Lys Leu Leu Glu Asn 
    130                 135                 140                 


Val Ser Glu Asn Glu Arg Ile Met Lys Val Asn Gly Tyr Lys Thr Val 
145                 150                 155                 160 


Gly Glu Met Phe Ser Lys His Glu Lys Phe Thr His His Lys Arg Asn 
                165                 170                 175     


Lys Asp Gly Ser Tyr Thr Ser Val Val Thr Arg Ser Leu Leu Leu Lys 
            180                 185                 190         


Glu Ile Lys Thr Ile Phe Asn Ser Gln Arg Ile Leu Gly Asn Val Phe 
        195                 200                 205             


Ser Thr Gln Lys Leu Glu Ser Asp Tyr Leu Tyr Ile Trp Gly Ser Gln 
    210                 215                 220                 


Arg Pro Thr Leu Thr Tyr Glu Gln Leu Met Ser Met Val Gly Asn Cys 
225                 230                 235                 240 


Ile Tyr Glu Lys Lys Glu Lys Arg Ala Pro Lys Thr Ser Trp Ala Phe 
                245                 250                 255     


Gln Tyr Phe Ser Leu Leu Gln Lys Ile Asn Lys Leu Lys Val Ser Asp 
            260                 265                 270         


Asp Asn Thr Leu Arg Lys Leu Ser Lys Glu Glu Arg Asp Ile Val Ile 
        275                 280                 285             


Glu Leu Ala Phe Lys Lys Lys Asn Val Ser Phe Val Asp Ile Arg Lys 
    290                 295                 300                 


Ala Leu Lys Leu Asn Asp Asn Thr Lys Phe Asn His Leu Thr Tyr Ser 
305                 310                 315                 320 


His Val Val Glu Thr Lys Lys Val Glu Lys Ala Thr Phe Ile Glu Leu 
                325                 330                 335     


Lys Gly Tyr His Leu Ile Lys Lys Gln Leu Lys Asp Arg Asn Val Glu 
            340                 345                 350         


Leu Thr Gln Glu Leu Gln Pro Lys Asp Tyr Asp Ala Ile Ala Ala Ala 
        355                 360                 365             


Ser Thr Phe Phe Lys Asn Asp Ile Glu Phe Arg Asp Tyr Leu Arg Asn 
    370                 375                 380                 


Gln Tyr Leu Asp Ser Asn Gly Lys Arg Lys Ser Asn Ile Ala Asn Lys 
385                 390                 395                 400 


Val Phe Glu Asp Lys Val Ile Ala Ala Val Phe Glu Leu Asn Phe Ser 
                405                 410                 415     


Lys Val Cys His Leu Ser Phe Lys Ser Leu Tyr Lys Leu Ile Pro His 
            420                 425                 430         


Leu Glu Lys Gly Leu Asp Tyr Lys Glu Ala Ile Leu Cys Ala Gly Tyr 
        435                 440                 445             


Asn Phe Arg Asp Glu Asn Lys Arg Asp Lys Lys Leu Phe Leu Pro Val 
    450                 455                 460                 


Ile Gln Gln Glu Thr Asn Pro Val Val His Arg Ala Leu Thr Gln Ala 
465                 470                 475                 480 


Arg Lys Val Ile Asn Ala Ile Ile Arg Glu Tyr Gly Ser Pro Asn Thr 
                485                 490                 495     


Ile Arg Phe Val Val Ala Asn Asp Leu Ala Lys Thr Tyr Lys Gln Arg 
            500                 505                 510         


Lys Glu Leu Glu Ser Thr Leu Lys Lys Asn Arg Ala Glu Asn Glu Lys 
        515                 520                 525             


Ile Lys Thr Lys Leu Leu Ser Met Gly Ile Ile Asn Pro Thr Gly Met 
    530                 535                 540                 


Asp Ile Val Lys Tyr Lys Leu Trp Tyr Glu Gln Ser Gly Ile Cys Leu 
545                 550                 555                 560 


Tyr Thr Gly Arg Gln Met Glu Leu Ser Ser Leu Phe Lys Pro Gly Tyr 
                565                 570                 575     


Ser Ile Val Asn His Ile Ile Pro Tyr Asn Arg Ser Phe Asp Asp Thr 
            580                 585                 590         


Tyr His Asn Arg Val Leu Thr Leu Thr Glu Thr Lys Tyr Glu Lys Gly 
        595                 600                 605             


Asn Lys Ile Pro Phe Glu Tyr Phe Gly Ala Glu Glu Thr Cys Trp Asn 
    610                 615                 620                 


Glu Tyr Glu Lys Arg Val Ser Thr Ser Lys Lys Ile His Asp Lys Lys 
625                 630                 635                 640 


Arg Glu Lys Leu Leu Ile Arg Asn Phe Asp Ile Glu Tyr Glu Asn Glu 
                645                 650                 655     


Met Ile Ser Asn Asn Val Phe Asp Thr His Tyr Ile Gly Ser Tyr Phe 
            660                 665                 670         


Glu Lys Tyr Ile Asp Glu His Leu Gln Phe Lys Lys Ser Thr Lys Lys 
        675                 680                 685             


Gln Lys Val Phe Ser Ile His Gly Asn Met Val Ala His Leu His Ser 
    690                 695                 700                 


Arg Trp Gly Phe Asn Lys Asn Ser Arg Glu Ile Tyr Leu Asn His Ala 
705                 710                 715                 720 


Val Asp Ala Ala Ile Val Ala Val Leu Thr Asp Gln Leu Ile Arg Asn 
                725                 730                 735     


Ile Ala Asp Tyr Tyr Arg Arg Asp Asn Ile Leu Glu Gln Lys Gly Ser 
            740                 745                 750         


Leu Lys Phe Pro Glu Pro Trp Lys Ser Phe Ser Ile Glu Leu Glu Ala 
        755                 760                 765             


Arg Ile Ser Pro Gln Val Arg Asp Leu Ile Lys Lys Leu Asn Leu Asp 
    770                 775                 780                 


Ser Tyr Leu Asp Val Asp Ile Leu His Ile Lys Pro Val Phe Ile Ser 
785                 790                 795                 800 


Lys Lys Pro Arg Arg Lys Val Asn Gly Glu Ala His Lys Ser Thr Ile 
                805                 810                 815     


Arg Ser Leu Ile Gly Ile Asn Glu Ile Gly Lys Thr Val Thr Cys Ile 
            820                 825                 830         


Lys Thr Arg Leu Glu Asp Ile Pro Phe Asp Glu Asn Gly Asp Phe Pro 
        835                 840                 845             


Met Tyr Gly Lys Asp Thr Asp Lys Tyr Thr Tyr Thr Ala Ile Lys Glu 
    850                 855                 860                 


Arg Tyr Leu Glu Phe Asn Lys Asp Lys Glu Lys Ala Phe Ser Thr Pro 
865                 870                 875                 880 


Leu Tyr Lys Leu Lys Arg Asn Gly Glu Pro Gly Asn Gln Ile Lys Ser 
                885                 890                 895     


Val Lys Ile Ile Asp Thr Arg Asn Ile Val Asn Lys Val Asn Gln Gly 
            900                 905                 910         


Lys Gly Ile Ala Tyr Asn Ser Asn Ile Ile Arg Val Asp Val Phe Ser 
        915                 920                 925             


Arg Asp Gln Lys Tyr Tyr Val Val Pro Ile Tyr Leu Arg Asp Phe Ile 
    930                 935                 940                 


Lys Gly Ser Leu Pro Asn Lys Ile Ile Thr Ala Ala Lys Gly Phe Met 
945                 950                 955                 960 


Gln Trp Pro Glu Thr Asp Asn Ser Tyr Thr Phe Leu Phe Ser Ile Phe 
                965                 970                 975     


Pro Asn Asp Leu Ile Lys Val Val Pro Lys Glu Gly Lys Phe Ile Lys 
            980                 985                 990         


Ala Lys Asn Glu Asn Lys Glu Asn  Ile Asn Leu Thr Glu  Ile Leu Gly 
        995                 1000                 1005             


Tyr Phe  Lys Gly Leu Asp Ser  Ser Thr Gly Ala Phe  Thr Leu Glu 
    1010                 1015                 1020             


Ser His  Asp Gly Ser Leu Leu  Ala Arg Gly Ile Gly  Thr Lys Asn 
    1025                 1030                 1035             


Leu Leu  Leu Ile Glu Lys Tyr  Gln Val Asp Val Leu  Gly Arg Tyr 
    1040                 1045                 1050             


Asn Lys  Val Gly Asn Glu Glu  Arg Gln Asp Ile Lys  Ile Gln Gln 
    1055                 1060                 1065             


Asn 
    


<210>  760
<211>  1131
<212>  PRT
<213>  Acidovorax ebreus TPSY

<400>  760

Met Ala Gln His Val Phe Gly Leu Asp Ile Gly Ile Ala Ser Val Gly 
1               5                   10                  15      


Trp Ala Ile Leu Gly Glu Gln Arg Ile Ile Asp Leu Gly Val Arg Cys 
            20                  25                  30          


Phe Asp Lys Ala Glu Thr Ala Lys Glu Gly Asp Pro Leu Asn Leu Thr 
        35                  40                  45              


Arg Arg Gln Ala Arg Leu Leu Arg Arg Arg Leu Tyr Arg Arg Ala Trp 
    50                  55                  60                  


Arg Leu Thr Gln Leu Ser Arg Leu Leu Lys Arg Lys Gly Leu Ile Ala 
65                  70                  75                  80  


Asp Ala Lys Leu Phe Ala Lys Ala Pro Ser Tyr Gly Asp Ser Ala Trp 
                85                  90                  95      


Glu Leu Arg Arg Gln Gly Leu Asp Arg Leu Leu Thr Pro Leu Glu Trp 
            100                 105                 110         


Ala Arg Val Ile Tyr His Gln Cys Lys His Arg Gly Phe His Trp Thr 
        115                 120                 125             


Ser Lys Ala Glu Glu Ala Lys Ala Asp Ser Asp Ala Glu Gly Gly Arg 
    130                 135                 140                 


Val Lys Gln Gly Leu Ala His Thr Lys Ala Leu Met Gln Ala Lys Asn 
145                 150                 155                 160 


Tyr Arg Ser Ala Ala Glu Met Val Leu Ala Glu Phe Pro Asp Ala Gln 
                165                 170                 175     


Arg Asn Lys Arg Gly Gln Tyr Asp Lys Ala Leu Ser Arg Val Leu Leu 
            180                 185                 190         


Gly Glu Glu Leu Ala Leu Leu Phe Ala Thr Gln Arg Arg Leu Gly Asn 
        195                 200                 205             


Pro His Ala Ser Asp Phe Phe Glu Lys Leu Ile Leu Gly Asp Gly Asp 
    210                 215                 220                 


Arg Lys Ser Gly Leu Phe Trp Gln Gln Lys Pro Ala Leu Ser Gly Ala 
225                 230                 235                 240 


Asp Leu Leu Lys Met Leu Gly Lys Cys Thr Phe Glu Lys Gly Glu Tyr 
                245                 250                 255     


Arg Ala Pro Lys Ala Ser Phe Ser Val Glu Arg His Val Trp Leu Thr 
            260                 265                 270         


Arg Leu Asn Asn Leu Arg Ile Val Val Asp Gly Arg Ser Arg Pro Leu 
        275                 280                 285             


Asn Glu Ala Glu Arg Gln Ala Ala Leu Leu Leu Pro Tyr Gln Thr Glu 
    290                 295                 300                 


Thr Ser Lys Tyr Lys Thr Leu Lys Asn Ala Phe Ile Lys Ala Gly Leu 
305                 310                 315                 320 


Trp Gly Asp Gly Val Arg Phe Gly Gly Leu Ala Tyr Pro Ser Gln Ala 
                325                 330                 335     


Gln Ile Asp Ala Glu Lys Thr Lys Asp Pro Glu Asp Gln Phe Leu Val 
            340                 345                 350         


Lys Leu Pro Ala Trp His Glu Leu Arg Lys Ala Phe Lys Ala Ala Gly 
        355                 360                 365             


His Glu Ala Leu Trp Gln Gln Ile Ser Thr Pro Ala Leu Asp Gly Asp 
    370                 375                 380                 


Pro Thr Leu Leu Asp Gln Ile Ala Thr Val Leu Ser Val Tyr Lys Asp 
385                 390                 395                 400 


Gly Ala Glu Val Val Gln Gln Leu Arg Gln Leu Ala Leu Pro Glu Pro 
                405                 410                 415     


Ala Ala Ser Ile Ala Val Leu Glu Lys Ile Ser Phe Asp Lys Phe Ser 
            420                 425                 430         


Ser Leu Ser Leu Lys Ala Leu Arg Arg Ile Val Pro Leu Met Gln Ser 
        435                 440                 445             


Gly Leu Arg Tyr Asp Glu Ala Val Ala Gln Ile Pro Glu Tyr Gly His 
    450                 455                 460                 


His Ser Gln Arg Ile Glu Pro Gly Ala Ala Lys His Leu Tyr Leu Pro 
465                 470                 475                 480 


Pro Phe Tyr Glu Ala Gln Arg Lys Tyr Ala Gly Lys Gly Asp His Ile 
                485                 490                 495     


Gly Ser Met Gln Phe Arg Asp Asp Ala Asp Ile Pro Arg Asn Pro Val 
            500                 505                 510         


Val Leu Arg Ala Leu Asn Gln Ala Arg Lys Val Val Asn Ala Leu Ile 
        515                 520                 525             


Arg Glu Tyr Gly Ser Pro Ile Ala Val Asn Ile Glu Met Ala Arg Asp 
    530                 535                 540                 


Leu Ser Arg Pro Leu Asp Glu Arg Asn Lys Val Lys Arg Ala Gln Glu 
545                 550                 555                 560 


Glu Phe Arg Asp Arg Asn Asp Arg Ala Arg Ser Glu Phe Glu Arg Asp 
                565                 570                 575     


Phe Gly Tyr Lys Pro Lys Ala Ala Ala Phe Glu Lys Trp Met Leu Tyr 
            580                 585                 590         


Arg Glu Gln Leu Gly Gln Cys Ala Tyr Ser Gln Gln Pro Leu Asp Ile 
        595                 600                 605             


Gln Arg Val Leu Asp Asp His Asn Tyr Ala Gln Val Asp His Ala Leu 
    610                 615                 620                 


Pro Tyr Ser Arg Ser Tyr Asp Asp Ser Lys Asn Asn Lys Val Leu Val 
625                 630                 635                 640 


Leu Thr His Glu Asn Gln Asn Lys Gly Asn Arg Thr Ala Phe Glu Tyr 
                645                 650                 655     


Leu Thr Ser Phe Pro Asp Gly Glu Asp Gly Glu Arg Trp Arg Thr Phe 
            660                 665                 670         


Val Ala Trp Val Gln Gly Asn Lys Ala Tyr Arg Met Ala Lys Arg Asn 
        675                 680                 685             


Arg Leu Leu Arg Lys Asn Tyr Gly Val Asp Glu Ser Lys Gly Phe Ile 
    690                 695                 700                 


Asp Arg Asn Leu Asn Asp Thr Arg Tyr Ile Cys Lys Phe Phe Lys Asn 
705                 710                 715                 720 


Tyr Val Glu Glu His Leu Gln Leu Ala Ala Arg Ala Asp Gly Asp Thr 
                725                 730                 735     


Ala Arg Arg Cys Val Val Val Asn Gly Gln Leu Thr Ala Phe Leu Arg 
            740                 745                 750         


Ala Arg Trp Gly Leu Thr Lys Val Arg Gly Asp Ser Asp Arg His His 
        755                 760                 765             


Ala Leu Asp Ala Ala Val Val Ala Ala Cys Thr His Gly Met Val Lys 
    770                 775                 780                 


Ala Leu Ala Asp Tyr Ser Arg Arg Lys Glu Ile Ser Phe Leu Gln Glu 
785                 790                 795                 800 


Gly Phe Pro Asp Pro Glu Thr Gly Glu Ile Leu Asn Pro Ala Ala Phe 
                805                 810                 815     


Asp Arg Ala Arg Gln His Phe Pro Glu Pro Trp Thr His Phe Ala His 
            820                 825                 830         


Glu Leu Lys Ala Arg Leu Phe Thr Asp Asp Leu Ala Ala Leu Arg Glu 
        835                 840                 845             


Asp Met Gln Arg Leu Gly Ser Tyr Thr Thr Glu Asp Leu Gly Arg Leu 
    850                 855                 860                 


Arg Thr Leu Phe Val Ser Arg Ala Pro Gln Arg Arg Ser Gly Gly Ala 
865                 870                 875                 880 


Val His Lys Glu Thr Ile Tyr Ala Gln Pro Glu Ser Leu Lys Gln Gln 
                885                 890                 895     


Gly Gly Val Ile Glu Lys Ile Leu Leu Thr Ser Leu Lys Leu Gln Asp 
            900                 905                 910         


Phe Asp Lys Leu Leu Asn Pro Glu Ser Asn Asp His Phe Val Glu Pro 
        915                 920                 925             


His Arg Asn Glu Arg Leu Tyr Ala Ala Ile Arg Gln Arg Leu Glu Gln 
    930                 935                 940                 


Phe Gly Gly Arg Ala Asp Lys Ala Phe Gly Pro Asp Asn Leu Phe His 
945                 950                 955                 960 


Lys Pro Asp Lys Asn Asn Gln Pro Thr Gly Pro Val Val Arg Ser Ile 
                965                 970                 975     


Lys Leu Val Arg Gly Lys Gln Thr Gly Ile Pro Ile Arg Gly Gly Leu 
            980                 985                 990         


Ala Lys Asn Asp Ser Met Leu Arg  Val Asp Ile Phe Thr  Lys Ala Gly 
        995                 1000                 1005             


Lys Phe  His Leu Val Pro Val  Tyr Val His His Arg  Val Thr Gly 
    1010                 1015                 1020             


Leu Pro  Asn Arg Ala Ile Val  Ala Phe Lys Asp Glu  Asp Glu Trp 
    1025                 1030                 1035             


Thr Leu  Ile Asp Glu Ser Phe  Ala Phe Leu Phe Ser  Val Tyr Pro 
    1040                 1045                 1050             


Asn Asp  Tyr Val Lys Val Thr  Leu Lys Lys Glu Gln  Gln Ser Gly 
    1055                 1060                 1065             


Tyr Tyr  Ser Gly Ala Asp Arg  Ser Thr Gly Ala Met  Asn Leu Trp 
    1070                 1075                 1080             


Ala His  Asp Arg Ala Ala Ser  Val Gly Lys Asp Gly  Leu Ile Arg 
    1085                 1090                 1095             


Gly Ile  Gly Val Lys Thr Ala  Leu Ser Val Glu Lys  Phe Asn Val 
    1100                 1105                 1110             


Asp Val  Leu Gly Arg Ile Tyr  Leu Ala Pro Pro Glu  Thr Arg Ser 
    1115                 1120                 1125             


Gly Leu  Ala 
    1130     


<210>  761
<211>  1032
<212>  PRT
<213>  Unknown

<220>
<223>  Description of unknown: uncultured Termite group 1 bacterium 
       phylotype RsD17

<400>  761

Met Lys Lys Arg Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val Gly 
1               5                   10                  15      


Trp Ala Leu Val Glu Phe Asp Asp Glu Phe Gln Asp Asn Lys Lys Lys 
            20                  25                  30          


Gly Thr Ile Ile Lys Ser Gly Val Arg Ile Phe Thr Arg Ala Glu Thr 
        35                  40                  45              


Pro Lys Glu Arg Glu Ser Leu Ala Lys Pro Arg Arg Glu Ala Arg Ser 
    50                  55                  60                  


Gln Arg Arg Arg Ile Arg Arg Arg Val Glu Arg Leu Asn Ser Ile Arg 
65                  70                  75                  80  


Glu Leu Phe Val Lys Asn Gly Val Val Glu Glu Trp Ser Val Ser Lys 
                85                  90                  95      


Lys Asn Pro Asn Asn Ile Tyr Ile Thr Leu Asn Gln Ile Lys Thr Pro 
            100                 105                 110         


Trp Gln Leu Arg Met Glu Ser Leu Asp Arg Lys Leu Thr Asn Glu Gln 
        115                 120                 125             


Phe Ala Val Val Leu Thr His Leu Ala Lys His Arg Gly Tyr Lys Ser 
    130                 135                 140                 


Leu Arg Lys Asp Asp Lys Ala Gly Lys Val Leu Glu Ala Ile Ser Gln 
145                 150                 155                 160 


Asn Lys Lys Arg Leu Asn Asp Ser Asp Tyr Arg Thr Leu Gly Glu Met 
                165                 170                 175     


Phe Cys Lys Asn Glu Ser Tyr Lys Glu His Lys Arg Asn Lys Gly Gly 
            180                 185                 190         


Glu Tyr Ile Asn Ser Val Ala Arg Glu Leu Ile Glu Glu Glu Val Glu 
        195                 200                 205             


Lys Ile Phe Val Lys Gln Arg Glu Lys Gly Asn Asn Phe Ala Asp Val 
    210                 215                 220                 


Asn Thr Glu Arg Glu Tyr Leu Lys Ile Ala Phe Ser Gln Lys Pro Ala 
225                 230                 235                 240 


Gly Ser Ile Ser Lys Met Val Gly Phe Cys Thr Phe Glu Asn Gly Glu 
                245                 250                 255     


Lys Arg Ala Pro Arg Asp Ser Tyr Ser Ala Glu Leu Phe Lys Val Leu 
            260                 265                 270         


Cys Thr Ile Asn Asn Thr Thr Phe Thr Asp Met Lys Thr Gly Glu Ile 
        275                 280                 285             


Arg Ser Phe Ser Lys Glu Glu Ile Gly Lys Thr Leu Glu Thr Val Lys 
    290                 295                 300                 


Asn Val Lys Asp Val Lys Tyr Ala Lys Ile Arg Lys Asp Leu Gly Leu 
305                 310                 315                 320 


Glu Asp Ser Val Lys Phe Ser Gly Val Asp Tyr Arg Glu Asn Ala Lys 
                325                 330                 335     


Ser Lys Gly Glu Gly Glu Ile Phe Val Ser Met Lys Thr Tyr His Glu 
            340                 345                 350         


Ile Lys Ser Lys Ile Glu Lys Leu Ser Lys Glu Lys Trp Asp Asn Leu 
        355                 360                 365             


Lys Gly Asn Thr Glu Leu Leu Asp Ser Ile Val Asn Ile Ile Ala Asn 
    370                 375                 380                 


Leu Lys Asp Asp Glu Ser Ile Lys Lys Glu Phe Gln Lys Leu Lys Ile 
385                 390                 395                 400 


Asp Glu Asp Ile Ile Asp Val Leu Leu Asn Phe Glu Phe Lys Lys Phe 
                405                 410                 415     


Ile Asn Leu Ser Phe Lys Ala Leu Arg Lys Ile Ile Pro Phe Gln Phe 
            420                 425                 430         


Gln Gly Gln Lys Tyr Ile Thr Ala Ser Thr Ser Ala Gly Tyr Ser Leu 
        435                 440                 445             


Lys Gln Glu Gly Ile Lys Asn Lys Leu Val Pro Pro Ala Lys Glu Asn 
    450                 455                 460                 


Ile Asn Val Ala Val Val Ala Arg Ala Phe Ala Gln Thr Arg Lys Val 
465                 470                 475                 480 


Ile Asn Ala Val Ile Arg Lys Tyr Gly Gln Phe Asp Gln Ile Asn Ile 
                485                 490                 495     


Glu Leu Ala Thr Glu Leu Lys Asn Ser Lys Phe Asp Arg Ser Lys Ile 
            500                 505                 510         


Glu Glu Gly Gln Lys Lys Phe Gln Ser Gln Lys Asp Lys Ile Phe Lys 
        515                 520                 525             


Glu Val Gln Glu Leu Arg Gly Gly Met Thr Pro Ser Ser Ser Leu Leu 
    530                 535                 540                 


Leu Lys Tyr Arg Leu Trp Arg Glu Gln Asp Glu Arg Cys Val Tyr Ser 
545                 550                 555                 560 


Gly Arg Lys Ile Ser Phe Glu Asp Leu Leu Asp Thr Gly Phe Leu Asp 
                565                 570                 575     


Ile Asp His Ile Ile Pro Tyr Ser Lys Ser Met Asp Asp Ser Phe Asn 
            580                 585                 590         


Asn Lys Val Leu Cys Leu Ala Glu Glu Asn Arg Asn Lys Lys Asn Asp 
        595                 600                 605             


Ile Pro Phe Asn Tyr Tyr Gln Arg Ile Asp Arg Asp Trp Asn Leu Leu 
    610                 615                 620                 


Ile Ser Ile Ile Thr Ser Met Lys Asn Met Lys Ile Ala Lys Lys Ser 
625                 630                 635                 640 


Arg Leu Leu Lys Gln Glu Leu Ser Asp Ile Glu Gly Phe Ile Glu Arg 
                645                 650                 655     


Asn Ile Asn Asp Thr Arg Tyr Ala Thr Arg Tyr Ile Lys Asp Phe Leu 
            660                 665                 670         


Glu Asn Asn Leu Glu Phe Lys Glu Asn Glu Phe Ile Lys Val Lys Val 
        675                 680                 685             


Gln Ala Arg Ser Gly Gly Leu Thr Ser Val Leu Ser Tyr Asn Trp Gly 
    690                 695                 700                 


Met Ser Lys Asp Arg Glu Glu Ser Tyr Phe His His Ala Lys Asp Ala 
705                 710                 715                 720 


Ile Ile Val Ala Cys Ser Thr Gln Gly Met Val Gln Tyr Ile Ser Lys 
                725                 730                 735     


Ile Ser Gln Gln Tyr Glu Asn Asp Lys Asp Lys Met Lys Lys Ile Lys 
            740                 745                 750         


Asp Lys Thr Glu Asn Cys Ile Pro Lys Pro Trp Asp Ser Phe Arg Ala 
        755                 760                 765             


Asp Val Glu Glu Ser Ile Glu Gly Ile Phe Val Ser Phe Ala Pro Arg 
    770                 775                 780                 


His Lys Val Thr Gly Ser Ala His Lys Glu Thr Ile Tyr Ser Lys Lys 
785                 790                 795                 800 


His Leu Glu Lys Glu Arg Tyr Val Thr Val Lys Lys Ser Leu Asp Lys 
                805                 810                 815     


Ile Lys Leu Ser Asp Leu Glu Asn Ile Pro Cys Asn Glu Asn Cys Gly 
            820                 825                 830         


Ile Ile Arg Val Leu Lys Glu Arg Leu Glu Lys Phe Lys Asn Asp Ser 
        835                 840                 845             


Leu Lys Ala Phe Ala Asp Pro Val His Met Pro Thr Lys Cys Pro Asn 
    850                 855                 860                 


Lys Lys Gly Pro Val Ile Arg Ser Val Lys Ile Lys Glu Ser Asn Lys 
865                 870                 875                 880 


Thr Gly Ile Glu Val Arg Lys Gly Leu Ala Glu Arg Gly Glu Met Val 
                885                 890                 895     


Arg Val Asp Val Phe Ile Lys Asp Lys Lys Tyr Tyr Leu Val Pro Ile 
            900                 905                 910         


Tyr Val Ser Asp Phe Lys Asn Lys Asp Leu Pro Asn Lys Ala Ile Ala 
        915                 920                 925             


Ala Leu Lys Leu Glu Asn Glu Trp Ile Met Ile Asp Lys Thr Tyr Ser 
    930                 935                 940                 


Phe Lys Phe Ser Leu Phe Lys Asp Asp Leu Ile Lys Ile Lys Lys Lys 
945                 950                 955                 960 


Lys Glu Glu Ile Phe Gly Tyr Phe Gly Gly Val His Arg Ser Thr Gly 
                965                 970                 975     


Thr Ile Lys Ile Lys Ser Arg His Lys Pro Lys Glu Ile Asp Glu Gly 
            980                 985                 990         


Ile Gly Ser Arg Cys Leu Leu Asp  Phe Arg Lys Phe Gln  Val Asp Val 
        995                 1000                 1005             


Leu Gly  Asn Tyr Thr Glu Val  Lys His Glu Lys Arg  Met Pro Ala 
    1010                 1015                 1020             


Tyr Ile  Thr Arg Lys Asp Lys  Lys His 
    1025                 1030         


<210>  762
<211>  1065
<212>  PRT
<213>  Clostridium perfringens D str. JGS1721

<400>  762

Met Asn Lys Asp Ile Asn Tyr Ala Leu Gly Leu Asp Ile Gly Ile Thr 
1               5                   10                  15      


Ser Val Gly Trp Ala Val Ile Asn Leu Asp Leu Asn Arg Ile Glu Asp 
            20                  25                  30          


Leu Gly Val Arg Ile Phe Asn Ala Ala Glu Asn Leu Lys Asp Gly Ser 
        35                  40                  45              


Ser Leu Ala Leu Pro Arg Arg Leu Ala Arg Gly Arg Arg Arg Leu Leu 
    50                  55                  60                  


Arg Arg Lys Ala Tyr Arg Val Glu Arg Val Arg Lys Leu Ile Leu Lys 
65                  70                  75                  80  


Asn Asn Ile Leu Thr Lys Glu Glu Leu Glu Gly Leu Phe Lys Asn Lys 
                85                  90                  95      


Glu Val Ile Asp Val Trp Glu Ala Arg Val Lys Gly Leu Asp Tyr Lys 
            100                 105                 110         


Leu Ser Arg Glu Glu Trp Ala Lys Ile Leu Ile Asn Phe Cys Lys Arg 
        115                 120                 125             


Arg Gly Phe Lys Ser Asn Arg Lys Asn Glu Ala Lys Asp Lys Glu Ala 
    130                 135                 140                 


Gly Gln Ile Leu Ser Ser Ile Ser Tyr Asn Ile Glu Lys Met Lys Glu 
145                 150                 155                 160 


Thr Asn Ser Arg Thr Ile Gly Glu Tyr Ile Tyr Asn Glu Val Lys Asn 
                165                 170                 175     


Ser Glu Asp Ser Tyr Ala Pro Leu Arg Asn Lys Phe Gly Glu Tyr Lys 
            180                 185                 190         


Met Cys Val Ser Arg Asp Val Ile Arg Glu Glu Ile His Thr Leu Phe 
        195                 200                 205             


Glu Lys Gln Arg Glu Leu Gly Asn Asn Phe Ala Ser Asp Glu Ile Glu 
    210                 215                 220                 


Asp Lys Tyr Phe Glu Ile Phe Asn Ser Gln Arg Pro Phe Ser Asn Phe 
225                 230                 235                 240 


Glu Asp Leu Glu Lys Leu Val Gly Phe Cys Thr Phe Glu Arg Lys Lys 
                245                 250                 255     


His Lys Arg Ala Pro Lys His Cys Ile Ser Ser Glu Glu Phe Thr Leu 
            260                 265                 270         


Tyr Glu Gly Ile Asn Lys Leu Ser Ile Ile Lys Asp Gly Glu Lys Arg 
        275                 280                 285             


Lys Leu Ser Glu Glu Glu Arg Thr Leu Val Val Asn Glu Ala Phe Asn 
    290                 295                 300                 


Lys Lys Glu Ile Lys Tyr Thr Thr Leu Arg Lys Leu Leu Gly Leu Ser 
305                 310                 315                 320 


Glu Glu Glu Leu Phe Ser Thr Leu Thr Tyr Ser Ile Asp Lys Asp Ile 
                325                 330                 335     


Ser Lys Thr Glu Asn Thr Lys Phe Val Ser Leu Lys Gly Tyr His Glu 
            340                 345                 350         


Ile Lys Arg Ala Ile Glu Lys Gly Val Ser Lys Lys Ala Trp Gln Asp 
        355                 360                 365             


Ile Glu Asn Asn Arg Asn Leu Leu Asn Asp Ile Ala Tyr Val Leu Thr 
    370                 375                 380                 


Leu Gly Lys Thr Asp Asp Glu Ile Glu Lys Gln Leu Arg Leu Arg Asn 
385                 390                 395                 400 


Val Pro Glu Glu Leu Phe Glu Ser Leu Leu Asp Met Ser Phe Asn Lys 
                405                 410                 415     


Phe Asn Asn Leu Ser Ile Tyr Ala Leu Glu Lys Ile Leu Pro Phe Met 
            420                 425                 430         


Lys Glu Gly Tyr Gln Tyr Asn Glu Ala Cys Glu Lys Ala Gly Tyr Asn 
        435                 440                 445             


Phe Lys Ala Ile Tyr Glu Gly Val Arg Thr Lys Lys Leu Pro Val Ile 
    450                 455                 460                 


Glu Ile Asp Glu Ile Val Asn Pro Val Val Asn Arg Ala Leu Ala Gln 
465                 470                 475                 480 


Thr Arg Lys Val Ile Asn Ser Val Ile Asp Lys Tyr Gly Ser Pro Val 
                485                 490                 495     


Arg Ile Asn Ile Glu Leu Ala Arg Asp Leu Ala Lys Asn Phe Lys Asp 
            500                 505                 510         


Arg Lys Leu Ile Glu Lys Glu Gln Lys Glu Asn Arg Ala Asn Leu Asp 
        515                 520                 525             


Lys Ile Arg Glu Asn Leu Arg Glu Leu Met Asp Lys Glu Pro Thr Val 
    530                 535                 540                 


Val Glu Val Leu Lys Tyr Arg Leu Trp Glu Gln Gln Arg Gly Glu Cys 
545                 550                 555                 560 


Ala Tyr Thr Gln Ser Gln Ile Pro Leu Glu Arg Leu Phe Ser Pro Gly 
                565                 570                 575     


Tyr Cys Glu Ile Asp His Ile Ile Pro Phe Ser Arg Ser Phe Asp Asp 
            580                 585                 590         


Ser Leu Ser Asn Lys Ile Leu Val Leu Gly Ser Glu Asn Gln Arg Lys 
        595                 600                 605             


Gly Asn Arg Thr Pro Tyr Glu Tyr Phe Gly Glu Asp Ser Glu Arg Trp 
    610                 615                 620                 


Asn Ser Phe Glu Ile Trp Val Lys Gly Ser Tyr Leu Asn Tyr Lys Lys 
625                 630                 635                 640 


Lys Ala Asn Leu Leu Lys Lys Lys Phe Ser Glu Glu Glu Gln Arg Asp 
                645                 650                 655     


Trp Lys Ala Arg Asn Leu Gln Asp Thr Lys Tyr Ile Cys Arg Tyr Ile 
            660                 665                 670         


Ser Asn Phe Val Asn Asn Arg Leu Glu Phe Lys Glu Ser Glu Asn Lys 
        675                 680                 685             


Gln Lys Val Ile Thr Val Asn Gly Arg Ala Thr Ala Tyr Leu Arg Ser 
    690                 695                 700                 


Arg Trp Gly Leu Asn Lys Val Arg Glu Asp Gly Asp Lys His His Ala 
705                 710                 715                 720 


Leu Asp Ala Ala Val Val Gly Val Thr Thr Gln Gly Met Val Gln Lys 
                725                 730                 735     


Ile Ser Lys Tyr Ser Lys Ala His Glu Leu Tyr Thr Val Arg Lys Asn 
            740                 745                 750         


Asp Glu Phe Val Asp Val Glu Thr Gly Glu Cys Val Asp Val Asp Glu 
        755                 760                 765             


Tyr Lys Glu Ile Arg Lys Asp Ile Leu Pro Arg Pro Trp Arg Gly Phe 
    770                 775                 780                 


Ser Glu Glu Leu Lys Leu Arg Leu Ser Asp Asn Pro Leu Glu Glu Leu 
785                 790                 795                 800 


Lys Lys Ser Pro Ile Glu Thr Tyr Asn Glu Glu Phe Ile Lys Glu Asn 
                805                 810                 815     


Val Lys Pro Ile Phe Val Ser Arg Val Pro Phe Arg Lys Ile Ser Gly 
            820                 825                 830         


Lys Leu Phe Lys Glu Thr Ile Tyr Ser Glu Arg Ala Phe Lys Asp Gly 
        835                 840                 845             


Tyr Phe Val Ser Lys Lys Ser Leu Val Asp Leu Lys Arg Gly Asp Leu 
    850                 855                 860                 


Asp Asn Phe Tyr Asn Tyr Glu Cys Asp Lys Lys Leu Tyr Asp Ala Ile 
865                 870                 875                 880 


Ser Glu Arg Met Lys Glu Phe Asn Tyr Asn Gly Lys Lys Ala Phe Glu 
                885                 890                 895     


Ser Pro Phe Arg Lys Pro Thr Lys Ser Gly Lys Glu Gly Pro Val Val 
            900                 905                 910         


Arg Ser Val Lys Ile Lys Ser Ala Val Pro Phe Lys Asp Gly Ile Pro 
        915                 920                 925             


Met Asn Glu Gly Leu Val Ala Lys Glu Gly Met Val Arg Ile Asp Ile 
    930                 935                 940                 


Tyr Glu Lys Glu Gly Lys Tyr Phe Val Val Pro Val Tyr Arg Tyr Gln 
945                 950                 955                 960 


Leu Ala Lys Gly Ile Val Pro Lys Arg Ala Ala Ile Ala Lys Lys Asp 
                965                 970                 975     


Glu Leu Lys Trp Pro Ile Met Asp Gln Thr Tyr Asn Phe Lys Phe Ser 
            980                 985                 990         


Ile Tyr Lys Asn Asp Leu Ile Glu  Val Lys Tyr Asp Lys  Lys Gly Val 
        995                 1000                 1005             


Tyr Phe  Gly Tyr Tyr Asp Gly  Phe Asp Arg Asn Ser  Ala Ser Leu 
    1010                 1015                 1020             


Thr Ile  Glu Lys His Asp Asn  Ser Glu Arg Tyr Arg  Ser Ile Gly 
    1025                 1030                 1035             


Leu Lys  Val Gly Val Leu Glu  Ile Asn Lys Tyr Glu  Val Asp Val 
    1040                 1045                 1050             


Leu Gly  Asn Tyr His Lys Val  Lys Leu Gly Gly Asn  
    1055                 1060                 1065 


<210>  763
<211>  1021
<212>  PRT
<213>  Clostridium cellulolyticum H10

<400>  763

Met Lys Tyr Thr Leu Gly Leu Asp Val Gly Ile Ala Ser Val Gly Trp 
1               5                   10                  15      


Ala Val Ile Asp Lys Asp Asn Asn Lys Ile Ile Asp Leu Gly Val Arg 
            20                  25                  30          


Cys Phe Asp Lys Ala Glu Glu Ser Lys Thr Gly Glu Ser Leu Ala Thr 
        35                  40                  45              


Ala Arg Arg Ile Ala Arg Gly Met Arg Arg Arg Ile Ser Arg Arg Ser 
    50                  55                  60                  


Gln Arg Leu Arg Leu Val Lys Lys Leu Phe Val Gln Tyr Glu Ile Ile 
65                  70                  75                  80  


Lys Asp Ser Ser Glu Phe Asn Arg Ile Phe Asp Thr Ser Arg Asp Gly 
                85                  90                  95      


Trp Lys Asp Pro Trp Glu Leu Arg Tyr Asn Ala Leu Ser Arg Ile Leu 
            100                 105                 110         


Lys Pro Tyr Glu Leu Val Gln Val Leu Thr His Ile Thr Lys Arg Arg 
        115                 120                 125             


Gly Phe Lys Ser Asn Arg Lys Glu Asp Leu Ser Thr Thr Lys Glu Gly 
    130                 135                 140                 


Val Val Ile Thr Ser Ile Lys Asn Asn Ser Glu Met Leu Arg Thr Lys 
145                 150                 155                 160 


Asn Tyr Arg Thr Ile Gly Glu Met Ile Phe Met Glu Thr Pro Glu Asn 
                165                 170                 175     


Ser Asn Lys Arg Asn Lys Val Asp Glu Tyr Ile His Thr Ile Ala Arg 
            180                 185                 190         


Glu Asp Leu Leu Asn Glu Ile Lys Tyr Ile Phe Ser Ile Gln Arg Lys 
        195                 200                 205             


Leu Gly Ser Pro Phe Val Thr Glu Lys Leu Glu His Asp Phe Leu Asn 
    210                 215                 220                 


Ile Trp Glu Phe Gln Arg Pro Phe Ala Ser Gly Asp Ser Ile Leu Ser 
225                 230                 235                 240 


Lys Val Gly Lys Cys Thr Leu Leu Lys Glu Glu Leu Arg Ala Pro Thr 
                245                 250                 255     


Ser Cys Tyr Thr Ser Glu Tyr Phe Gly Leu Leu Gln Ser Ile Asn Asn 
            260                 265                 270         


Leu Val Leu Val Glu Asp Asn Asn Thr Leu Thr Leu Asn Asn Asp Gln 
        275                 280                 285             


Arg Ala Lys Ile Ile Glu Tyr Ala His Phe Lys Asn Glu Ile Lys Tyr 
    290                 295                 300                 


Ser Glu Ile Arg Lys Leu Leu Asp Ile Glu Pro Glu Ile Leu Phe Lys 
305                 310                 315                 320 


Ala His Asn Leu Thr His Lys Asn Pro Ser Gly Asn Asn Glu Ser Lys 
                325                 330                 335     


Lys Phe Tyr Glu Met Lys Ser Tyr His Lys Leu Lys Ser Thr Leu Pro 
            340                 345                 350         


Thr Asp Ile Trp Gly Lys Leu His Ser Asn Lys Glu Ser Leu Asp Asn 
        355                 360                 365             


Leu Phe Tyr Cys Leu Thr Val Tyr Lys Asn Asp Asn Glu Ile Lys Asp 
    370                 375                 380                 


Tyr Leu Gln Ala Asn Asn Leu Asp Tyr Leu Ile Glu Tyr Ile Ala Lys 
385                 390                 395                 400 


Leu Pro Thr Phe Asn Lys Phe Lys His Leu Ser Leu Val Ala Met Lys 
                405                 410                 415     


Arg Ile Ile Pro Phe Met Glu Lys Gly Tyr Lys Tyr Ser Asp Ala Cys 
            420                 425                 430         


Asn Met Ala Glu Leu Asp Phe Thr Gly Ser Ser Lys Leu Glu Lys Cys 
        435                 440                 445             


Asn Lys Leu Thr Val Glu Pro Ile Ile Glu Asn Val Thr Asn Pro Val 
    450                 455                 460                 


Val Ile Arg Ala Leu Thr Gln Ala Arg Lys Val Ile Asn Ala Ile Ile 
465                 470                 475                 480 


Gln Lys Tyr Gly Leu Pro Tyr Met Val Asn Ile Glu Leu Ala Arg Glu 
                485                 490                 495     


Ala Gly Met Thr Arg Gln Asp Arg Asp Asn Leu Lys Lys Glu His Glu 
            500                 505                 510         


Asn Asn Arg Lys Ala Arg Glu Lys Ile Ser Asp Leu Ile Arg Gln Asn 
        515                 520                 525             


Gly Arg Val Ala Ser Gly Leu Asp Ile Leu Lys Trp Arg Leu Trp Glu 
    530                 535                 540                 


Asp Gln Gly Gly Arg Cys Ala Tyr Ser Gly Lys Pro Ile Pro Val Cys 
545                 550                 555                 560 


Asp Leu Leu Asn Asp Ser Leu Thr Gln Ile Asp His Ile Tyr Pro Tyr 
                565                 570                 575     


Ser Arg Ser Met Asp Asp Ser Tyr Met Asn Lys Val Leu Val Leu Thr 
            580                 585                 590         


Asp Glu Asn Gln Asn Lys Arg Ser Tyr Thr Pro Tyr Glu Val Trp Gly 
        595                 600                 605             


Ser Thr Glu Lys Trp Glu Asp Phe Glu Ala Arg Ile Tyr Ser Met His 
    610                 615                 620                 


Leu Pro Gln Ser Lys Glu Lys Arg Leu Leu Asn Arg Asn Phe Ile Thr 
625                 630                 635                 640 


Lys Asp Leu Asp Ser Phe Ile Ser Arg Asn Leu Asn Asp Thr Arg Tyr 
                645                 650                 655     


Ile Ser Arg Phe Leu Lys Asn Tyr Ile Glu Ser Tyr Leu Gln Phe Ser 
            660                 665                 670         


Asn Asp Ser Pro Lys Ser Cys Val Val Cys Val Asn Gly Gln Cys Thr 
        675                 680                 685             


Ala Gln Leu Arg Ser Arg Trp Gly Leu Asn Lys Asn Arg Glu Glu Ser 
    690                 695                 700                 


Asp Leu His His Ala Leu Asp Ala Ala Val Ile Ala Cys Ala Asp Arg 
705                 710                 715                 720 


Lys Ile Ile Lys Glu Ile Thr Asn Tyr Tyr Asn Glu Arg Glu Asn His 
                725                 730                 735     


Asn Tyr Lys Val Lys Tyr Pro Leu Pro Trp His Ser Phe Arg Gln Asp 
            740                 745                 750         


Leu Met Glu Thr Leu Ala Gly Val Phe Ile Ser Arg Ala Pro Arg Arg 
        755                 760                 765             


Lys Ile Thr Gly Pro Ala His Asp Glu Thr Ile Arg Ser Pro Lys His 
    770                 775                 780                 


Phe Asn Lys Gly Leu Thr Ser Val Lys Ile Pro Leu Thr Thr Val Thr 
785                 790                 795                 800 


Leu Glu Lys Leu Glu Thr Met Val Lys Asn Thr Lys Gly Gly Ile Ser 
                805                 810                 815     


Asp Lys Ala Val Tyr Asn Val Leu Lys Asn Arg Leu Ile Glu His Asn 
            820                 825                 830         


Asn Lys Pro Leu Lys Ala Phe Ala Glu Lys Ile Tyr Lys Pro Leu Lys 
        835                 840                 845             


Asn Gly Thr Asn Gly Ala Ile Ile Arg Ser Ile Arg Val Glu Thr Pro 
    850                 855                 860                 


Ser Tyr Thr Gly Val Phe Arg Asn Glu Gly Lys Gly Ile Ser Asp Asn 
865                 870                 875                 880 


Ser Leu Met Val Arg Val Asp Val Phe Lys Lys Lys Asp Lys Tyr Tyr 
                885                 890                 895     


Leu Val Pro Ile Tyr Val Ala His Met Ile Lys Lys Glu Leu Pro Ser 
            900                 905                 910         


Lys Ala Ile Val Pro Leu Lys Pro Glu Ser Gln Trp Glu Leu Ile Asp 
        915                 920                 925             


Ser Thr His Glu Phe Leu Phe Ser Leu Tyr Gln Asn Asp Tyr Leu Val 
    930                 935                 940                 


Ile Lys Thr Lys Lys Gly Ile Thr Glu Gly Tyr Tyr Arg Ser Cys His 
945                 950                 955                 960 


Arg Gly Thr Gly Ser Leu Ser Leu Met Pro His Phe Ala Asn Asn Lys 
                965                 970                 975     


Asn Val Lys Ile Asp Ile Gly Val Arg Thr Ala Ile Ser Ile Glu Lys 
            980                 985                 990         


Tyr Asn Val Asp Ile Leu Gly Asn  Lys Ser Ile Val Lys  Gly Glu Pro 
        995                 1000                 1005             


Arg Arg  Gly Met Glu Lys Tyr  Asn Ser Phe Lys Ser  Asn 
    1010                 1015                 1020     


<210>  764
<211>  1037
<212>  PRT
<213>  Parvibaculum lavamentivorans DS-1

<400>  764

Met Glu Arg Ile Phe Gly Phe Asp Ile Gly Thr Thr Ser Ile Gly Phe 
1               5                   10                  15      


Ser Val Ile Asp Tyr Ser Ser Thr Gln Ser Ala Gly Asn Ile Gln Arg 
            20                  25                  30          


Leu Gly Val Arg Ile Phe Pro Glu Ala Arg Asp Pro Asp Gly Thr Pro 
        35                  40                  45              


Leu Asn Gln Gln Arg Arg Gln Lys Arg Met Met Arg Arg Gln Leu Arg 
    50                  55                  60                  


Arg Arg Arg Ile Arg Arg Lys Ala Leu Asn Glu Thr Leu His Glu Ala 
65                  70                  75                  80  


Gly Phe Leu Pro Ala Tyr Gly Ser Ala Asp Trp Pro Val Val Met Ala 
                85                  90                  95      


Asp Glu Pro Tyr Glu Leu Arg Arg Arg Gly Leu Glu Glu Gly Leu Ser 
            100                 105                 110         


Ala Tyr Glu Phe Gly Arg Ala Ile Tyr His Leu Ala Gln His Arg His 
        115                 120                 125             


Phe Lys Gly Arg Glu Leu Glu Glu Ser Asp Thr Pro Asp Pro Asp Val 
    130                 135                 140                 


Asp Asp Glu Lys Glu Ala Ala Asn Glu Arg Ala Ala Thr Leu Lys Ala 
145                 150                 155                 160 


Leu Lys Asn Glu Gln Thr Thr Leu Gly Ala Trp Leu Ala Arg Arg Pro 
                165                 170                 175     


Pro Ser Asp Arg Lys Arg Gly Ile His Ala His Arg Asn Val Val Ala 
            180                 185                 190         


Glu Glu Phe Glu Arg Leu Trp Glu Val Gln Ser Lys Phe His Pro Ala 
        195                 200                 205             


Leu Lys Ser Glu Glu Met Arg Ala Arg Ile Ser Asp Thr Ile Phe Ala 
    210                 215                 220                 


Gln Arg Pro Val Phe Trp Arg Lys Asn Thr Leu Gly Glu Cys Arg Phe 
225                 230                 235                 240 


Met Pro Gly Glu Pro Leu Cys Pro Lys Gly Ser Trp Leu Ser Gln Gln 
                245                 250                 255     


Arg Arg Met Leu Glu Lys Leu Asn Asn Leu Ala Ile Ala Gly Gly Asn 
            260                 265                 270         


Ala Arg Pro Leu Asp Ala Glu Glu Arg Asp Ala Ile Leu Ser Lys Leu 
        275                 280                 285             


Gln Gln Gln Ala Ser Met Ser Trp Pro Gly Val Arg Ser Ala Leu Lys 
    290                 295                 300                 


Ala Leu Tyr Lys Gln Arg Gly Glu Pro Gly Ala Glu Lys Ser Leu Lys 
305                 310                 315                 320 


Phe Asn Leu Glu Leu Gly Gly Glu Ser Lys Leu Leu Gly Asn Ala Leu 
                325                 330                 335     


Glu Ala Lys Leu Ala Asp Met Phe Gly Pro Asp Trp Pro Ala His Pro 
            340                 345                 350         


Arg Lys Gln Glu Ile Arg His Ala Val His Glu Arg Leu Trp Ala Ala 
        355                 360                 365             


Asp Tyr Gly Glu Thr Pro Asp Lys Lys Arg Val Ile Ile Leu Ser Glu 
    370                 375                 380                 


Lys Asp Arg Lys Ala His Arg Glu Ala Ala Ala Asn Ser Phe Val Ala 
385                 390                 395                 400 


Asp Phe Gly Ile Thr Gly Glu Gln Ala Ala Gln Leu Gln Ala Leu Lys 
                405                 410                 415     


Leu Pro Thr Gly Trp Glu Pro Tyr Ser Ile Pro Ala Leu Asn Leu Phe 
            420                 425                 430         


Leu Ala Glu Leu Glu Lys Gly Glu Arg Phe Gly Ala Leu Val Asn Gly 
        435                 440                 445             


Pro Asp Trp Glu Gly Trp Arg Arg Thr Asn Phe Pro His Arg Asn Gln 
    450                 455                 460                 


Pro Thr Gly Glu Ile Leu Asp Lys Leu Pro Ser Pro Ala Ser Lys Glu 
465                 470                 475                 480 


Glu Arg Glu Arg Ile Ser Gln Leu Arg Asn Pro Thr Val Val Arg Thr 
                485                 490                 495     


Gln Asn Glu Leu Arg Lys Val Val Asn Asn Leu Ile Gly Leu Tyr Gly 
            500                 505                 510         


Lys Pro Asp Arg Ile Arg Ile Glu Val Gly Arg Asp Val Gly Lys Ser 
        515                 520                 525             


Lys Arg Glu Arg Glu Glu Ile Gln Ser Gly Ile Arg Arg Asn Glu Lys 
    530                 535                 540                 


Gln Arg Lys Lys Ala Thr Glu Asp Leu Ile Lys Asn Gly Ile Ala Asn 
545                 550                 555                 560 


Pro Ser Arg Asp Asp Val Glu Lys Trp Ile Leu Trp Lys Glu Gly Gln 
                565                 570                 575     


Glu Arg Cys Pro Tyr Thr Gly Asp Gln Ile Gly Phe Asn Ala Leu Phe 
            580                 585                 590         


Arg Glu Gly Arg Tyr Glu Val Glu His Ile Trp Pro Arg Ser Arg Ser 
        595                 600                 605             


Phe Asp Asn Ser Pro Arg Asn Lys Thr Leu Cys Arg Lys Asp Val Asn 
    610                 615                 620                 


Ile Glu Lys Gly Asn Arg Met Pro Phe Glu Ala Phe Gly His Asp Glu 
625                 630                 635                 640 


Asp Arg Trp Ser Ala Ile Gln Ile Arg Leu Gln Gly Met Val Ser Ala 
                645                 650                 655     


Lys Gly Gly Thr Gly Met Ser Pro Gly Lys Val Lys Arg Phe Leu Ala 
            660                 665                 670         


Lys Thr Met Pro Glu Asp Phe Ala Ala Arg Gln Leu Asn Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ala Lys Gln Ile Leu Ala Gln Leu Lys Arg Leu Trp Pro Asp 
    690                 695                 700                 


Met Gly Pro Glu Ala Pro Val Lys Val Glu Ala Val Thr Gly Gln Val 
705                 710                 715                 720 


Thr Ala Gln Leu Arg Lys Leu Trp Thr Leu Asn Asn Ile Leu Ala Asp 
                725                 730                 735     


Asp Gly Glu Lys Thr Arg Ala Asp His Arg His His Ala Ile Asp Ala 
            740                 745                 750         


Leu Thr Val Ala Cys Thr His Pro Gly Met Thr Asn Lys Leu Ser Arg 
        755                 760                 765             


Tyr Trp Gln Leu Arg Asp Asp Pro Arg Ala Glu Lys Pro Ala Leu Thr 
    770                 775                 780                 


Pro Pro Trp Asp Thr Ile Arg Ala Asp Ala Glu Lys Ala Val Ser Glu 
785                 790                 795                 800 


Ile Val Val Ser His Arg Val Arg Lys Lys Val Ser Gly Pro Leu His 
                805                 810                 815     


Lys Glu Thr Thr Tyr Gly Asp Thr Gly Thr Asp Ile Lys Thr Lys Ser 
            820                 825                 830         


Gly Thr Tyr Arg Gln Phe Val Thr Arg Lys Lys Ile Glu Ser Leu Ser 
        835                 840                 845             


Lys Gly Glu Leu Asp Glu Ile Arg Asp Pro Arg Ile Lys Glu Ile Val 
    850                 855                 860                 


Ala Ala His Val Ala Gly Arg Gly Gly Asp Pro Lys Lys Ala Phe Pro 
865                 870                 875                 880 


Pro Tyr Pro Cys Val Ser Pro Gly Gly Pro Glu Ile Arg Lys Val Arg 
                885                 890                 895     


Leu Thr Ser Lys Gln Gln Leu Asn Leu Met Ala Gln Thr Gly Asn Gly 
            900                 905                 910         


Tyr Ala Asp Leu Gly Ser Asn His His Ile Ala Ile Tyr Arg Leu Pro 
        915                 920                 925             


Asp Gly Lys Ala Asp Phe Glu Ile Val Ser Leu Phe Asp Ala Ser Arg 
    930                 935                 940                 


Arg Leu Ala Gln Arg Asn Pro Ile Val Gln Arg Thr Arg Ala Asp Gly 
945                 950                 955                 960 


Ala Ser Phe Val Met Ser Leu Ala Ala Gly Glu Ala Ile Met Ile Pro 
                965                 970                 975     


Glu Gly Ser Lys Lys Gly Ile Trp Ile Val Gln Gly Val Trp Ala Ser 
            980                 985                 990         


Gly Gln Val Val Leu Glu Arg Asp  Thr Asp Ala Asp His  Ser Thr Thr 
        995                 1000                 1005             


Thr Arg  Pro Met Pro Asn Pro  Ile Leu Lys Asp Asp  Ala Lys Lys 
    1010                 1015                 1020             


Val Ser  Ile Asp Pro Ile Gly  Arg Val Arg Pro Ser  Asn Asp 
    1025                 1030                 1035         


<210>  765
<211>  1140
<212>  PRT
<213>  Roseburia intestinalis L1-82

<400>  765

Met Arg Glu Asn Gly Ser Asp Glu Arg Arg Arg Asn Met Asp Glu Lys 
1               5                   10                  15      


Met Asp Tyr Arg Ile Gly Leu Asp Ile Gly Ile Ala Ser Val Gly Trp 
            20                  25                  30          


Ala Val Leu Gln Asn Asn Ser Asp Asp Glu Pro Val Arg Ile Val Asp 
        35                  40                  45              


Leu Gly Val Arg Ile Phe Asp Thr Ala Glu Ile Pro Lys Thr Gly Glu 
    50                  55                  60                  


Ser Leu Ala Gly Pro Arg Arg Ala Ala Arg Thr Thr Arg Arg Arg Leu 
65                  70                  75                  80  


Arg Arg Arg Lys His Arg Leu Asp Arg Ile Lys Trp Leu Phe Glu Asn 
                85                  90                  95      


Gln Gly Leu Ile Asn Ile Asp Asp Phe Leu Lys Arg Tyr Asn Met Ala 
            100                 105                 110         


Gly Leu Pro Asp Val Tyr Gln Leu Arg Tyr Glu Ala Leu Asp Arg Lys 
        115                 120                 125             


Leu Thr Asp Glu Glu Leu Ala Gln Val Leu Leu His Ile Ala Lys His 
    130                 135                 140                 


Arg Gly Phe Arg Ser Thr Arg Lys Ala Glu Thr Ala Ala Lys Glu Asn 
145                 150                 155                 160 


Gly Ala Val Leu Lys Ala Thr Asp Glu Asn Gln Lys Arg Met Gln Glu 
                165                 170                 175     


Lys Gly Tyr Arg Thr Val Gly Glu Met Ile Tyr Leu Asp Glu Ala Phe 
            180                 185                 190         


Arg Thr Gly Cys Ser Trp Ser Glu Lys Gly Tyr Ile Leu Thr Pro Arg 
        195                 200                 205             


Asn Lys Ala Glu Asn Tyr Gln His Thr Met Leu Arg Ala Met Leu Val 
    210                 215                 220                 


Glu Glu Val Lys Glu Ile Phe Ser Ser Gln Arg Arg Leu Gly Asn Glu 
225                 230                 235                 240 


Lys Ala Thr Glu Glu Leu Glu Glu Lys Tyr Leu Glu Ile Met Thr Ser 
                245                 250                 255     


Gln Arg Ser Phe Asp Leu Gly Pro Gly Met Gln Pro Asp Gly Lys Pro 
            260                 265                 270         


Ser Pro Tyr Ala Met Glu Gly Phe Ser Asp Arg Val Gly Lys Cys Thr 
        275                 280                 285             


Phe Leu Gly Asp Gln Gly Glu Leu Arg Gly Ala Lys Gly Thr Tyr Thr 
    290                 295                 300                 


Ala Glu Tyr Phe Val Ala Leu Gln Lys Ile Asn His Thr Lys Leu Val 
305                 310                 315                 320 


Asn Gln Asp Gly Glu Thr Arg Asn Phe Thr Glu Glu Glu Arg Arg Ala 
                325                 330                 335     


Leu Thr Leu Leu Leu Phe Thr Gln Lys Glu Val Lys Tyr Ala Ala Val 
            340                 345                 350         


Arg Lys Lys Leu Gly Leu Pro Glu Asp Ile Leu Phe Tyr Asn Leu Asn 
        355                 360                 365             


Tyr Lys Lys Ala Ala Thr Lys Glu Glu Gln Gln Lys Glu Asn Gln Asn 
    370                 375                 380                 


Thr Glu Lys Ala Lys Phe Ile Gly Met Pro Tyr Tyr His Asp Tyr Lys 
385                 390                 395                 400 


Lys Cys Leu Glu Glu Arg Val Lys Tyr Leu Thr Glu Asn Glu Val Arg 
                405                 410                 415     


Asp Leu Phe Asp Glu Ile Gly Met Ile Leu Thr Cys Tyr Lys Asn Asp 
            420                 425                 430         


Asp Ser Arg Thr Glu Arg Leu Ala Lys Leu Gly Leu Val Pro Ile Glu 
        435                 440                 445             


Met Glu Gly Leu Leu Ala Tyr Thr Pro Thr Lys Phe Gln His Leu Ser 
    450                 455                 460                 


Met Lys Ala Met Arg Asn Ile Ile Pro Phe Leu Glu Lys Gly Met Thr 
465                 470                 475                 480 


Tyr Asp Lys Ala Cys Glu Glu Ala Gly Tyr Asp Phe Lys Ala Asp Ser 
                485                 490                 495     


Lys Gly Thr Lys Gln Lys Leu Leu Thr Gly Glu Asn Val Asn Gln Thr 
            500                 505                 510         


Ile Asn Glu Ile Thr Asn Pro Val Val Lys Arg Ser Val Ser Gln Thr 
        515                 520                 525             


Val Lys Val Ile Asn Ala Ile Ile Arg Thr Tyr Gly Ser Pro Gln Ala 
    530                 535                 540                 


Ile Asn Ile Glu Leu Ala Arg Glu Met Ser Lys Thr Phe Glu Glu Arg 
545                 550                 555                 560 


Arg Lys Ile Lys Gly Asp Met Glu Lys Arg Gln Lys Asn Asn Glu Asp 
                565                 570                 575     


Val Lys Lys Gln Ile Gln Glu Leu Gly Lys Leu Ser Pro Thr Gly Gln 
            580                 585                 590         


Asp Ile Leu Lys Tyr Arg Leu Trp Gln Glu Gln Gln Gly Ile Cys Met 
        595                 600                 605             


Tyr Ser Gly Lys Thr Ile Pro Leu Glu Glu Leu Phe Lys Pro Gly Tyr 
    610                 615                 620                 


Asp Ile Asp His Ile Leu Pro Tyr Ser Ile Thr Phe Asp Asp Ser Phe 
625                 630                 635                 640 


Arg Asn Lys Val Leu Val Thr Ser Gln Glu Asn Arg Gln Lys Gly Asn 
                645                 650                 655     


Arg Thr Pro Tyr Glu Tyr Met Gly Asn Asp Glu Gln Arg Trp Asn Glu 
            660                 665                 670         


Phe Glu Thr Arg Val Lys Thr Thr Ile Arg Asp Tyr Lys Lys Gln Gln 
        675                 680                 685             


Lys Leu Leu Lys Lys His Phe Ser Glu Glu Glu Arg Ser Glu Phe Lys 
    690                 695                 700                 


Glu Arg Asn Leu Thr Asp Thr Lys Tyr Ile Thr Thr Val Ile Tyr Asn 
705                 710                 715                 720 


Met Ile Arg Gln Asn Leu Glu Met Ala Pro Leu Asn Arg Pro Glu Lys 
                725                 730                 735     


Lys Lys Gln Val Arg Ala Val Asn Gly Ala Ile Thr Ala Tyr Leu Arg 
            740                 745                 750         


Lys Arg Trp Gly Leu Pro Gln Lys Asn Arg Glu Thr Asp Thr His His 
        755                 760                 765             


Ala Met Asp Ala Val Val Ile Ala Cys Cys Thr Asp Gly Met Ile Gln 
    770                 775                 780                 


Lys Ile Ser Arg Tyr Thr Lys Val Arg Glu Arg Cys Tyr Ser Lys Gly 
785                 790                 795                 800 


Thr Glu Phe Val Asp Ala Glu Thr Gly Glu Ile Phe Arg Pro Glu Asp 
                805                 810                 815     


Tyr Ser Arg Ala Glu Trp Asp Glu Ile Phe Gly Val His Ile Pro Lys 
            820                 825                 830         


Pro Trp Glu Thr Phe Arg Ala Glu Leu Asp Val Arg Met Gly Asp Asp 
        835                 840                 845             


Pro Lys Gly Phe Leu Asp Thr His Ser Asp Val Ala Leu Glu Leu Asp 
    850                 855                 860                 


Tyr Pro Glu Tyr Ile Tyr Glu Asn Leu Arg Pro Ile Phe Val Ser Arg 
865                 870                 875                 880 


Met Pro Asn His Lys Val Thr Gly Ala Ala His Ala Asp Thr Ile Arg 
                885                 890                 895     


Ser Pro Arg His Phe Lys Asp Glu Gly Ile Val Leu Thr Lys Thr Ala 
            900                 905                 910         


Leu Thr Asp Leu Lys Leu Asp Lys Asp Gly Glu Ile Asp Gly Tyr Tyr 
        915                 920                 925             


Asn Pro Gln Ser Asp Leu Leu Leu Tyr Glu Ala Leu Lys Lys Gln Leu 
    930                 935                 940                 


Leu Leu Tyr Gly Asn Asp Ala Lys Lys Ala Phe Ala Gln Asp Phe His 
945                 950                 955                 960 


Lys Pro Lys Ala Asp Gly Thr Glu Gly Pro Val Val Arg Lys Val Lys 
                965                 970                 975     


Ile Gln Lys Lys Gln Thr Met Gly Val Phe Val Asp Ser Gly Asn Gly 
            980                 985                 990         


Ile Ala Glu Asn Gly Gly Met Val  Arg Ile Asp Val Phe  Arg Val Asn 
        995                 1000                 1005             


Gly Lys  Tyr Tyr Phe Val Pro  Val Tyr Thr Ala Asp  Val Val Lys 
    1010                 1015                 1020             


Lys Val  Leu Pro Asn Arg Ala  Ser Thr Ala His Lys  Pro Tyr Gly 
    1025                 1030                 1035             


Glu Trp  Lys Val Met Glu Asp  Lys Asp Phe Leu Phe  Ser Leu Tyr 
    1040                 1045                 1050             


Ser Arg  Asp Leu Ile His Ile  Lys Ser Lys Lys Asp  Ile Pro Ile 
    1055                 1060                 1065             


Lys Met  Val Asn Gly Gly Met  Glu Gly Ile Lys Glu  Thr Tyr Ala 
    1070                 1075                 1080             


Tyr Tyr  Ile Gly Ala Asp Ile  Ser Ala Ala Asn Ile  Gln Gly Ile 
    1085                 1090                 1095             


Ala His  Asp Ser Arg Tyr Lys  Phe Arg Gly Leu Gly  Ile Gln Ser 
    1100                 1105                 1110             


Leu Asp  Val Leu Glu Lys Cys  Gln Ile Asp Val Leu  Gly His Val 
    1115                 1120                 1125             


Ser Val  Val Arg Ser Glu Lys  Arg Met Gly Phe Ser  
    1130                 1135                 1140 


<210>  766
<211>  1082
<212>  PRT
<213>  Neisseria meningitidis Z2491

<400>  766

Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Asp 
            20                  25                  30          


Glu Asn Pro Ile Cys Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210>  767
<211>  1056
<212>  PRT
<213>  Pasteurella multocida subsp. multocida str. Pm70

<400>  767

Met Gln Thr Thr Asn Leu Ser Tyr Ile Leu Gly Leu Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Val Gly Trp Ala Val Val Glu Ile Asn Glu Asn Glu Asp Pro 
            20                  25                  30          


Ile Gly Leu Ile Asp Val Gly Val Arg Ile Phe Glu Arg Ala Glu Val 
        35                  40                  45              


Pro Lys Thr Gly Glu Ser Leu Ala Leu Ser Arg Arg Leu Ala Arg Ser 
    50                  55                  60                  


Thr Arg Arg Leu Ile Arg Arg Arg Ala His Arg Leu Leu Leu Ala Lys 
65                  70                  75                  80  


Arg Phe Leu Lys Arg Glu Gly Ile Leu Ser Thr Ile Asp Leu Glu Lys 
                85                  90                  95      


Gly Leu Pro Asn Gln Ala Trp Glu Leu Arg Val Ala Gly Leu Glu Arg 
            100                 105                 110         


Arg Leu Ser Ala Ile Glu Trp Gly Ala Val Leu Leu His Leu Ile Lys 
        115                 120                 125             


His Arg Gly Tyr Leu Ser Lys Arg Lys Asn Glu Ser Gln Thr Asn Asn 
    130                 135                 140                 


Lys Glu Leu Gly Ala Leu Leu Ser Gly Val Ala Gln Asn His Gln Leu 
145                 150                 155                 160 


Leu Gln Ser Asp Asp Tyr Arg Thr Pro Ala Glu Leu Ala Leu Lys Lys 
                165                 170                 175     


Phe Ala Lys Glu Glu Gly His Ile Arg Asn Gln Arg Gly Ala Tyr Thr 
            180                 185                 190         


His Thr Phe Asn Arg Leu Asp Leu Leu Ala Glu Leu Asn Leu Leu Phe 
        195                 200                 205             


Ala Gln Gln His Gln Phe Gly Asn Pro His Cys Lys Glu His Ile Gln 
    210                 215                 220                 


Gln Tyr Met Thr Glu Leu Leu Met Trp Gln Lys Pro Ala Leu Ser Gly 
225                 230                 235                 240 


Glu Ala Ile Leu Lys Met Leu Gly Lys Cys Thr His Glu Lys Asn Glu 
                245                 250                 255     


Phe Lys Ala Ala Lys His Thr Tyr Ser Ala Glu Arg Phe Val Trp Leu 
            260                 265                 270         


Thr Lys Leu Asn Asn Leu Arg Ile Leu Glu Asp Gly Ala Glu Arg Ala 
        275                 280                 285             


Leu Asn Glu Glu Glu Arg Gln Leu Leu Ile Asn His Pro Tyr Glu Lys 
    290                 295                 300                 


Ser Lys Leu Thr Tyr Ala Gln Val Arg Lys Leu Leu Gly Leu Ser Glu 
305                 310                 315                 320 


Gln Ala Ile Phe Lys His Leu Arg Tyr Ser Lys Glu Asn Ala Glu Ser 
                325                 330                 335     


Ala Thr Phe Met Glu Leu Lys Ala Trp His Ala Ile Arg Lys Ala Leu 
            340                 345                 350         


Glu Asn Gln Gly Leu Lys Asp Thr Trp Gln Asp Leu Ala Lys Lys Pro 
        355                 360                 365             


Asp Leu Leu Asp Glu Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr Asp 
    370                 375                 380                 


Glu Asp Ile Gln Gln Tyr Leu Thr Asn Lys Val Pro Asn Ser Val Ile 
385                 390                 395                 400 


Asn Ala Leu Leu Val Ser Leu Asn Phe Asp Lys Phe Ile Glu Leu Ser 
                405                 410                 415     


Leu Lys Ser Leu Arg Lys Ile Leu Pro Leu Met Glu Gln Gly Lys Arg 
            420                 425                 430         


Tyr Asp Gln Ala Cys Arg Glu Ile Tyr Gly His His Tyr Gly Glu Ala 
        435                 440                 445             


Asn Gln Lys Thr Ser Gln Leu Leu Pro Ala Ile Pro Ala Gln Glu Ile 
    450                 455                 460                 


Arg Asn Pro Val Val Leu Arg Thr Leu Ser Gln Ala Arg Lys Val Ile 
465                 470                 475                 480 


Asn Ala Ile Ile Arg Gln Tyr Gly Ser Pro Ala Arg Val His Ile Glu 
                485                 490                 495     


Thr Gly Arg Glu Leu Gly Lys Ser Phe Lys Glu Arg Arg Glu Ile Gln 
            500                 505                 510         


Lys Gln Gln Glu Asp Asn Arg Thr Lys Arg Glu Ser Ala Val Gln Lys 
        515                 520                 525             


Phe Lys Glu Leu Phe Ser Asp Phe Ser Ser Glu Pro Lys Ser Lys Asp 
    530                 535                 540                 


Ile Leu Lys Phe Arg Leu Tyr Glu Gln Gln His Gly Lys Cys Leu Tyr 
545                 550                 555                 560 


Ser Gly Lys Glu Ile Asn Ile His Arg Leu Asn Glu Lys Gly Tyr Val 
                565                 570                 575     


Glu Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe 
            580                 585                 590         


Asn Asn Lys Val Leu Val Leu Ala Ser Glu Asn Gln Asn Lys Gly Asn 
        595                 600                 605             


Gln Thr Pro Tyr Glu Trp Leu Gln Gly Lys Ile Asn Ser Glu Arg Trp 
    610                 615                 620                 


Lys Asn Phe Val Ala Leu Val Leu Gly Ser Gln Cys Ser Ala Ala Lys 
625                 630                 635                 640 


Lys Gln Arg Leu Leu Thr Gln Val Ile Asp Asp Asn Lys Phe Ile Asp 
                645                 650                 655     


Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ala Arg Phe Leu Ser Asn Tyr 
            660                 665                 670         


Ile Gln Glu Asn Leu Leu Leu Val Gly Lys Asn Lys Lys Asn Val Phe 
        675                 680                 685             


Thr Pro Asn Gly Gln Ile Thr Ala Leu Leu Arg Ser Arg Trp Gly Leu 
    690                 695                 700                 


Ile Lys Ala Arg Glu Asn Asn Asn Arg His His Ala Leu Asp Ala Ile 
705                 710                 715                 720 


Val Val Ala Cys Ala Thr Pro Ser Met Gln Gln Lys Ile Thr Arg Phe 
                725                 730                 735     


Ile Arg Phe Lys Glu Val His Pro Tyr Lys Ile Glu Asn Arg Tyr Glu 
            740                 745                 750         


Met Val Asp Gln Glu Ser Gly Glu Ile Ile Ser Pro His Phe Pro Glu 
        755                 760                 765             


Pro Trp Ala Tyr Phe Arg Gln Glu Val Asn Ile Arg Val Phe Asp Asn 
    770                 775                 780                 


His Pro Asp Thr Val Leu Lys Glu Met Leu Pro Asp Arg Pro Gln Ala 
785                 790                 795                 800 


Asn His Gln Phe Val Gln Pro Leu Phe Val Ser Arg Ala Pro Thr Arg 
                805                 810                 815     


Lys Met Ser Gly Gln Gly His Met Glu Thr Ile Lys Ser Ala Lys Arg 
            820                 825                 830         


Leu Ala Glu Gly Ile Ser Val Leu Arg Ile Pro Leu Thr Gln Leu Lys 
        835                 840                 845             


Pro Asn Leu Leu Glu Asn Met Val Asn Lys Glu Arg Glu Pro Ala Leu 
    850                 855                 860                 


Tyr Ala Gly Leu Lys Ala Arg Leu Ala Glu Phe Asn Gln Asp Pro Ala 
865                 870                 875                 880 


Lys Ala Phe Ala Thr Pro Phe Tyr Lys Gln Gly Gly Gln Gln Val Lys 
                885                 890                 895     


Ala Ile Arg Val Glu Gln Val Gln Lys Ser Gly Val Leu Val Arg Glu 
            900                 905                 910         


Asn Asn Gly Val Ala Asp Asn Ala Ser Ile Val Arg Thr Asp Val Phe 
        915                 920                 925             


Ile Lys Asn Asn Lys Phe Phe Leu Val Pro Ile Tyr Thr Trp Gln Val 
    930                 935                 940                 


Ala Lys Gly Ile Leu Pro Asn Lys Ala Ile Val Ala His Lys Asn Glu 
945                 950                 955                 960 


Asp Glu Trp Glu Glu Met Asp Glu Gly Ala Lys Phe Lys Phe Ser Leu 
                965                 970                 975     


Phe Pro Asn Asp Leu Val Glu Leu Lys Thr Lys Lys Glu Tyr Phe Phe 
            980                 985                 990         


Gly Tyr Tyr Ile Gly Leu Asp Arg  Ala Thr Gly Asn Ile  Ser Leu Lys 
        995                 1000                 1005             


Glu His  Asp Gly Glu Ile Ser  Lys Gly Lys Asp Gly  Val Tyr Arg 
    1010                 1015                 1020             


Val Gly  Val Lys Leu Ala Leu  Ser Phe Glu Lys Tyr  Gln Val Asp 
    1025                 1030                 1035             


Glu Leu  Gly Lys Asn Arg Gln  Ile Cys Arg Pro Gln  Gln Arg Gln 
    1040                 1045                 1050             


Pro Val  Arg 
    1055     


<210>  768
<211>  1422
<212>  PRT
<213>  Sutterella wadsworthensis 3 1 45B

<400>  768

Met Thr Gln Ser Glu Arg Arg Phe Ser Cys Ser Ile Gly Ile Asp Met 
1               5                   10                  15      


Gly Ala Lys Tyr Thr Gly Val Phe Tyr Ala Leu Phe Asp Arg Glu Glu 
            20                  25                  30          


Leu Pro Thr Asn Leu Asn Ser Lys Ala Met Thr Leu Val Met Pro Glu 
        35                  40                  45              


Thr Gly Pro Arg Tyr Val Gln Ala Gln Arg Thr Ala Val Arg His Arg 
    50                  55                  60                  


Leu Arg Gly Gln Lys Arg Tyr Thr Leu Ala Arg Lys Leu Ala Phe Leu 
65                  70                  75                  80  


Val Val Asp Asp Met Ile Lys Lys Gln Glu Lys Arg Leu Thr Asp Glu 
                85                  90                  95      


Glu Trp Lys Arg Gly Arg Glu Ala Leu Ser Gly Leu Leu Lys Arg Arg 
            100                 105                 110         


Gly Tyr Ser Arg Pro Asn Ala Asp Gly Glu Asp Leu Thr Pro Leu Glu 
        115                 120                 125             


Asn Val Arg Ala Asp Val Phe Ala Ala His Pro Ala Phe Ser Thr Tyr 
    130                 135                 140                 


Phe Ser Glu Val Arg Ser Leu Ala Glu Gln Trp Glu Glu Phe Thr Ala 
145                 150                 155                 160 


Asn Ile Ser Asn Val Glu Lys Phe Leu Gly Asp Pro Asn Ile Pro Ala 
                165                 170                 175     


Asp Lys Glu Phe Ile Glu Phe Ala Val Ala Glu Gly Leu Ile Asp Lys 
            180                 185                 190         


Thr Glu Lys Lys Ala Tyr Gln Ser Ala Leu Ser Thr Leu Arg Ala Asn 
        195                 200                 205             


Ala Asn Val Leu Thr Gly Leu Arg Gln Met Gly His Lys Pro Arg Ser 
    210                 215                 220                 


Glu Tyr Phe Lys Ala Ile Glu Ala Asp Leu Lys Lys Asp Ser Arg Leu 
225                 230                 235                 240 


Ala Lys Ile Asn Glu Ala Phe Gly Gly Ala Glu Arg Leu Ala Arg Leu 
                245                 250                 255     


Leu Gly Asn Leu Ser Asn Leu Gln Leu Arg Ala Glu Arg Trp Tyr Phe 
            260                 265                 270         


Asn Ala Pro Asp Ile Met Lys Asp Arg Gly Trp Glu Pro Asp Arg Phe 
        275                 280                 285             


Lys Lys Thr Leu Val Arg Ala Phe Lys Phe Phe His Pro Ala Lys Asp 
    290                 295                 300                 


Gln Asn Lys Gln His Leu Glu Leu Ile Lys Gln Ile Glu Asn Ser Glu 
305                 310                 315                 320 


Asp Ile Ile Glu Thr Leu Cys Thr Leu Asp Pro Asn Arg Thr Ile Pro 
                325                 330                 335     


Pro Tyr Glu Asp Gln Asn Asn Arg Arg Pro Pro Leu Asp Gln Thr Leu 
            340                 345                 350         


Leu Leu Ser Pro Glu Lys Leu Thr Arg Gln Tyr Gly Glu Ile Trp Lys 
        355                 360                 365             


Thr Trp Ser Ala Arg Leu Thr Ser Ala Glu Pro Thr Leu Ala Pro Ala 
    370                 375                 380                 


Ala Glu Ile Leu Glu Arg Ser Thr Asp Arg Lys Ser Arg Val Ala Val 
385                 390                 395                 400 


Asn Gly His Glu Pro Leu Pro Thr Leu Ala Tyr Gln Leu Ser Tyr Ala 
                405                 410                 415     


Leu Gln Arg Ala Phe Asp Arg Ser Lys Ala Leu Asp Pro Tyr Ala Leu 
            420                 425                 430         


Arg Ala Leu Ala Ala Gly Ser Lys Ser Asn Lys Leu Thr Ser Ala Arg 
        435                 440                 445             


Thr Ala Leu Glu Asn Cys Ile Gly Gly Gln Asn Val Lys Thr Phe Leu 
    450                 455                 460                 


Asp Cys Ala Arg Arg Tyr Tyr Arg Glu Ala Asp Asp Ala Lys Val Gly 
465                 470                 475                 480 


Leu Trp Phe Asp Asn Ala Asp Gly Leu Leu Glu Arg Ser Asp Leu His 
                485                 490                 495     


Pro Pro Met Lys Lys Lys Ile Leu Pro Leu Leu Val Ala Asn Ile Leu 
            500                 505                 510         


Gln Thr Asp Glu Thr Thr Gly Gln Lys Phe Leu Asp Glu Ile Trp Arg 
        515                 520                 525             


Lys Gln Ile Lys Gly Arg Glu Thr Val Ala Ser Arg Cys Ala Arg Ile 
    530                 535                 540                 


Glu Thr Val Arg Lys Ser Phe Gly Gly Gly Phe Asn Ile Ala Tyr Asn 
545                 550                 555                 560 


Thr Ala Gln Tyr Arg Glu Val Asn Lys Leu Pro Arg Asn Ala Gln Asp 
                565                 570                 575     


Lys Glu Leu Leu Thr Ile Arg Asp Arg Val Ala Glu Thr Ala Asp Phe 
            580                 585                 590         


Ile Ala Ala Asn Leu Gly Leu Ser Asp Glu Gln Lys Arg Lys Phe Ala 
        595                 600                 605             


Asn Pro Phe Ser Leu Ala Gln Phe Tyr Thr Leu Ile Glu Thr Glu Val 
    610                 615                 620                 


Ser Gly Phe Ser Ala Thr Thr Leu Ala Val His Leu Glu Asn Ala Trp 
625                 630                 635                 640 


Arg Met Thr Ile Lys Asp Ala Val Ile Asn Gly Glu Thr Val Arg Ala 
                645                 650                 655     


Ala Gln Cys Ser Arg Leu Pro Ala Glu Thr Ala Arg Pro Phe Asp Gly 
            660                 665                 670         


Leu Val Arg Arg Leu Val Asp Arg Gln Ala Trp Glu Ile Ala Lys Arg 
        675                 680                 685             


Val Ser Thr Asp Ile Gln Ser Lys Val Asp Phe Ser Asn Gly Ile Val 
    690                 695                 700                 


Asp Val Ser Ile Phe Val Glu Glu Asn Lys Phe Glu Phe Ser Ala Ser 
705                 710                 715                 720 


Val Ala Asp Leu Lys Lys Asn Lys Arg Val Lys Asp Lys Met Leu Ser 
                725                 730                 735     


Glu Ala Glu Lys Leu Glu Thr Arg Trp Leu Ile Lys Asn Glu Arg Ile 
            740                 745                 750         


Lys Lys Ala Ser Arg Gly Thr Cys Pro Tyr Thr Gly Asp Arg Leu Ala 
        755                 760                 765             


Glu Gly Gly Glu Ile Asp His Ile Leu Pro Arg Ser Leu Ile Lys Asp 
    770                 775                 780                 


Ala Arg Gly Ile Val Phe Asn Ala Glu Pro Asn Leu Ile Tyr Ala Ser 
785                 790                 795                 800 


Ser Arg Gly Asn Gln Leu Lys Lys Asn Gln Arg Tyr Ser Leu Ser Asp 
                805                 810                 815     


Leu Lys Ala Asn Tyr Arg Asn Glu Ile Phe Lys Thr Ser Asn Ile Ala 
            820                 825                 830         


Ala Ile Thr Ala Glu Ile Glu Asp Val Val Thr Lys Leu Gln Gln Thr 
        835                 840                 845             


His Arg Leu Lys Phe Phe Asp Leu Leu Asn Glu His Glu Gln Asp Cys 
    850                 855                 860                 


Val Arg His Ala Leu Phe Leu Asp Asp Gly Ser Glu Ala Arg Asp Ala 
865                 870                 875                 880 


Val Leu Glu Leu Leu Ala Thr Gln Arg Arg Thr Arg Val Asn Gly Thr 
                885                 890                 895     


Gln Ile Trp Met Ile Lys Asn Leu Ala Asn Lys Ile Arg Glu Glu Leu 
            900                 905                 910         


Gln Asn Trp Cys Lys Thr Thr Asn Asn Arg Leu His Phe Gln Ala Ala 
        915                 920                 925             


Ala Thr Asn Val Ser Asp Ala Lys Asn Leu Arg Leu Lys Leu Ala Gln 
    930                 935                 940                 


Asn Gln Pro Asp Phe Glu Lys Pro Asp Ile Gln Pro Ile Ala Ser His 
945                 950                 955                 960 


Ser Ile Asp Ala Leu Cys Ser Phe Ala Val Gly Ser Ala Asp Ala Glu 
                965                 970                 975     


Arg Asp Gln Asn Gly Phe Asp Tyr Leu Asp Gly Lys Thr Val Leu Gly 
            980                 985                 990         


Leu Tyr Pro Gln Ser Cys Glu Val  Ile His Leu Gln Ala  Lys Pro Gln 
        995                 1000                 1005             


Glu Glu  Lys Ser His Phe Asp  Ser Val Ala Ile Phe  Lys Glu Gly 
    1010                 1015                 1020             


Ile Tyr  Ala Glu Gln Phe Leu  Pro Ile Phe Thr Leu  Asn Glu Lys 
    1025                 1030                 1035             


Ile Trp  Ile Gly Tyr Glu Thr  Leu Asn Ala Lys Gly  Glu Arg Cys 
    1040                 1045                 1050             


Gly Ala  Ile Glu Val Ser Gly  Lys Gln Pro Lys Glu  Leu Leu Glu 
    1055                 1060                 1065             


Met Leu  Ala Pro Phe Phe Asn  Lys Pro Val Gly Asp  Leu Ser Ala 
    1070                 1075                 1080             


His Ala  Thr Tyr Arg Ile Leu  Lys Lys Pro Ala Tyr  Glu Phe Leu 
    1085                 1090                 1095             


Ala Lys  Ala Ala Leu Gln Pro  Leu Ser Ala Glu Glu  Lys Arg Leu 
    1100                 1105                 1110             


Ala Ala  Leu Leu Asp Ala Leu  Arg Tyr Cys Thr Ser  Arg Lys Ser 
    1115                 1120                 1125             


Leu Met  Ser Leu Phe Met Ala  Ala Asn Gly Lys Ser  Leu Lys Lys 
    1130                 1135                 1140             


Arg Glu  Asp Val Leu Lys Pro  Lys Leu Phe Gln Leu  Lys Val Glu 
    1145                 1150                 1155             


Leu Lys  Gly Glu Lys Ser Phe  Lys Leu Asn Gly Ser  Leu Thr Leu 
    1160                 1165                 1170             


Pro Val  Lys Gln Asp Trp Leu  Arg Ile Cys Asp Ser  Pro Glu Leu 
    1175                 1180                 1185             


Ala Asp  Ala Phe Gly Lys Pro  Cys Ser Ala Asp Glu  Leu Thr Ser 
    1190                 1195                 1200             


Lys Leu  Ala Arg Ile Trp Lys  Arg Pro Val Met Arg  Asp Leu Ala 
    1205                 1210                 1215             


His Ala  Pro Val Arg Arg Glu  Phe Ser Leu Pro Ala  Ile Asp Asn 
    1220                 1225                 1230             


Pro Ser  Gly Gly Phe Arg Ile  Arg Arg Thr Asn Leu  Phe Gly Asn 
    1235                 1240                 1245             


Glu Leu  Tyr Gln Val His Ala  Ile Asn Ala Lys Lys  Tyr Arg Gly 
    1250                 1255                 1260             


Phe Ala  Ser Ala Gly Ser Asn  Val Asp Trp Ser Lys  Gly Ile Leu 
    1265                 1270                 1275             


Phe Asn  Glu Leu Gln His Glu  Asn Leu Thr Glu Cys  Gly Gly Arg 
    1280                 1285                 1290             


Phe Ile  Thr Ser Ala Asp Val  Thr Pro Met Ser Glu  Trp Arg Lys 
    1295                 1300                 1305             


Val Val  Ala Glu Asp Asn Leu  Ser Ile Trp Ile Ala  Pro Gly Thr 
    1310                 1315                 1320             


Glu Gly  Arg Arg Tyr Val Arg  Val Glu Thr Thr Phe  Ile Gln Ala 
    1325                 1330                 1335             


Ser His  Trp Phe Glu Gln Ser  Val Glu Asn Trp Ala  Ile Thr Ser 
    1340                 1345                 1350             


Pro Leu  Ser Leu Pro Ala Ser  Phe Lys Val Asp Lys  Pro Ala Glu 
    1355                 1360                 1365             


Phe Gln  Lys Ala Val Gly Thr  Glu Leu Ser Glu Leu  Leu Gly Gln 
    1370                 1375                 1380             


Pro Arg  Ser Glu Ile Phe Ile  Glu Asn Val Gly Asn  Ala Lys His 
    1385                 1390                 1395             


Ile Arg  Phe Trp Tyr Ile Val  Val Ser Ser Asn Lys  Lys Met Asn 
    1400                 1405                 1410             


Glu Ser  Tyr Asn Asn Val Ser  Lys Ser 
    1415                 1420         


<210>  769
<211>  1397
<212>  PRT
<213>  gamma proteobacterium HTCC5015

<400>  769

Met Thr Lys Asn Tyr Ile Ser Pro Ile Ala Ile Asp Leu Gly Ala Lys 
1               5                   10                  15      


Phe Thr Gly Val Ala Leu Tyr Gln Tyr Leu Glu Gly Ala Asp Cys Thr 
            20                  25                  30          


Gln Glu Val Ala Lys Gly Leu Leu Val Asp Asp Arg Gly Asn Val Thr 
        35                  40                  45              


Trp Ser Gln Glu Gly Arg Arg Gly Lys Arg His Gln Val Arg Gly Tyr 
    50                  55                  60                  


Lys Arg Arg Lys Met Ala Lys Arg Leu Leu Trp Leu Ile Leu Asp Ser 
65                  70                  75                  80  


Glu Tyr Gly Ile Lys Arg Glu Glu Val Thr Glu Pro Leu Leu Lys Phe 
                85                  90                  95      


Ile Asn Gly Leu Leu Asn Arg Arg Gly Tyr Thr Tyr Ile Ser Glu Glu 
            100                 105                 110         


Val Asp Glu Glu Ser Met Asn Val Ser Pro Leu Pro Phe Ser Glu Met 
        115                 120                 125             


Met Pro Asp Tyr Phe Asn Ser Ser Ala Pro Leu Leu Glu Gln Leu Ala 
    130                 135                 140                 


Lys Leu Leu Ser Asp Lys Asn Lys Leu Val Arg Phe Arg Ala Glu Gly 
145                 150                 155                 160 


Lys Ile Pro Ser Asn Lys Asn Glu Phe Lys Lys Leu Leu Asp Thr Ala 
                165                 170                 175     


Leu Asp Gly Lys Tyr Lys Asp Glu Lys Lys Glu Leu Ser Glu Ala Trp 
            180                 185                 190         


Gly Asn Ile Leu Ile Ala Ser Glu Asn Val Leu Lys Ser Thr Val Asp 
        195                 200                 205             


Gly His Lys Ser Arg Ser Glu Tyr Leu Ala Asn Ile Lys Glu Asp Ile 
    210                 215                 220                 


Lys Ser Asn Glu Glu Leu Glu Lys Gln Ile Ser Ser Lys Glu Ile Asp 
225                 230                 235                 240 


Gly Phe Tyr Asn Leu Val Gly His Leu Ser Asn Phe Gln Leu Arg Leu 
                245                 250                 255     


Leu Arg Lys Tyr Phe Asn Asp Pro Asn Met Ser Gly Val Ser Tyr Trp 
            260                 265                 270         


Asp Glu Lys Arg Leu Glu Lys Tyr Phe Tyr Gln Trp Val Gln Gly Trp 
        275                 280                 285             


His Thr Lys Gly Gly Thr Asp Glu Ala Glu Lys Lys Asn Ile Ile Leu 
    290                 295                 300                 


Lys Thr Lys Gly Ala Pro Leu Leu Lys Thr Leu Lys Ser Leu Ser Ala 
305                 310                 315                 320 


Asp Leu Thr Ile Pro Pro Tyr Glu Asp Gln Asn Asn Arg Arg Pro Pro 
                325                 330                 335     


Lys Cys Gln Ser Val Leu Leu Ser Asp Glu Lys Leu Thr Met His Tyr 
            340                 345                 350         


Pro Lys Trp Lys Glu Trp Val Gly Gln Leu Val Lys Gln Asn Asp Asn 
        355                 360                 365             


Ala Tyr Leu Asn Glu Asn Val Thr Leu Ala Asn Ala Leu His Arg Ile 
    370                 375                 380                 


Val Glu Arg Ser Arg Ser Ile Asp Pro Tyr Gln Leu Arg Leu Leu Ile 
385                 390                 395                 400 


Ser Ile Thr Asp Ala Glu Lys Arg Asn Asp Leu Ala Gly Tyr Lys Arg 
                405                 410                 415     


Leu Lys Leu Ser Leu Gly Ser Glu Val Asp Glu Phe Leu Leu Leu Val 
            420                 425                 430         


Lys Asn Ile Val Asp Glu Thr Lys Glu Ala Arg Glu Gly Leu Trp Phe 
        435                 440                 445             


Glu Thr Glu Asn Lys Leu Phe Phe Lys Cys Gly Lys Thr Pro Pro Arg 
    450                 455                 460                 


Lys Glu Lys Leu Lys Ser Thr Leu Leu Ser Ala Val Leu Gly Lys Asn 
465                 470                 475                 480 


Leu Ser Asp Asp Glu Gln Ser Ser Phe Ile Glu Glu Phe Trp Lys Ser 
                485                 490                 495     


Gly Thr Pro Lys Ile Glu Arg Arg Asn Val Arg Gly Trp Cys Arg Leu 
            500                 505                 510         


Ala Ser Gln Val Gln Lys Thr Tyr Gly Val Tyr Leu Lys Glu Tyr Gly 
        515                 520                 525             


Leu Gln Gln Leu His Lys Leu Glu Ala Gly Lys Lys Leu Asp Asp Lys 
    530                 535                 540                 


Pro Leu Ala Leu Leu Tyr Lys Asn Ser Gly Leu Ile Ala Ser Lys Ile 
545                 550                 555                 560 


Gly Glu Ala Leu Asn Ile Glu Pro Asp Glu Val Ser Arg Phe Ala Ser 
                565                 570                 575     


Pro His Ser Leu Ala Gln Ile Phe Asn Ile Ile Glu Gly Asp Val Ala 
            580                 585                 590         


Gly Phe Asn Lys Thr Cys Arg Ala Cys Thr Tyr Glu Asn Ile Trp Arg 
        595                 600                 605             


Met Gln Glu Glu Lys Val Glu Ser Leu Leu Thr Asn Gln Leu Leu Ser 
    610                 615                 620                 


Glu Ile His Gly Glu Arg Lys Val Pro Leu Lys Ser Ala Met Cys Thr 
625                 630                 635                 640 


Arg Leu Ser Ala Asp Ser Thr Arg Pro Phe Asp Gly Gln Met Ala Ser 
                645                 650                 655     


Ile Ile Glu His Ile Ala Arg Lys Ile Ala Gln His Lys Ile Ala Gln 
            660                 665                 670         


Ile Asn Asp Val Pro Lys Glu Phe Ser Ile Asp Ile Pro Ile Ile Ile 
        675                 680                 685             


Glu Ser Asn Gln Phe Ser Phe Thr Ala Glu Leu Glu Glu Ile Lys Arg 
    690                 695                 700                 


Gly Arg Gly Ser Ala Lys Ala Lys Lys Ala Lys Glu Leu Gly Glu Lys 
705                 710                 715                 720 


Ser Lys Ala Gly Trp Val Ser Lys Thr Glu Arg Ile Lys Thr Ser Ser 
                725                 730                 735     


Glu Gly Ile Cys Pro Tyr Thr Gly Ala Pro Leu Gly Gly Ser Gly Glu 
            740                 745                 750         


Ile Asp His Ile Ile Pro Arg Ser Leu Thr Gly Arg Thr Lys Lys Thr 
        755                 760                 765             


Val Phe Asn Ser Glu Ala Asn Leu Ile Tyr Cys Ser Ser Lys Gly Asn 
    770                 775                 780                 


His Asp Lys Gly Asn Arg Val Tyr Val Ile Glu Gln Leu Asn Asp Lys 
785                 790                 795                 800 


Tyr Leu Lys Lys Gln Phe Ser Thr Ser Asp Val Asn Leu Ile Lys Lys 
                805                 810                 815     


Lys Ile Lys Thr Thr Ile Gln Arg Phe Thr Glu Gly Gly Glu Lys Leu 
            820                 825                 830         


Arg Ser Phe Ser Glu Leu Ser Arg Glu Asp Gln Lys Ala Phe Arg His 
        835                 840                 845             


Ala Leu Phe Val Pro Glu Leu Lys Ser Glu Val Thr Ser Leu Leu Ala 
    850                 855                 860                 


Val Lys Asn Ile Thr Arg Val Asn Gly Thr Gln Ala Trp Leu Ala Lys 
865                 870                 875                 880 


Lys Ile Ala Ser Leu Leu Ala Glu His Leu Asp Lys Gln Gly Arg Asp 
                885                 890                 895     


Tyr Thr Leu Ser Ala His Gln Ile Asp Pro Trp Ser Val Ser Lys Gln 
            900                 905                 910         


Arg Lys Met Leu Ala Ser Ala Glu Pro Ile Trp Ala Lys Lys Asp Pro 
        915                 920                 925             


Gln Pro Ala Ala Ser His Val Val Asp Ala Val Cys Thr Phe Leu Glu 
    930                 935                 940                 


Ala Leu Glu Gln Pro His Thr Ala Ser Arg Leu Lys Thr Ile Ser Ser 
945                 950                 955                 960 


Thr Ser Phe Glu Lys Thr Gly Trp Arg Ser Ala Leu Ile Pro Asp Leu 
                965                 970                 975     


Ile Lys Val Asp Ala Leu Asp Arg Arg Pro Lys Tyr Arg Arg Tyr Asn 
            980                 985                 990         


Ile Gly Ser Thr Ser Leu Phe Lys  Asp Gly Ile Tyr Ala  Glu Arg Phe 
        995                 1000                 1005             


Leu Pro  Ile Leu Ile Asp Glu  Asn Gly Leu Met Ala  Gly Tyr Asp 
    1010                 1015                 1020             


Ile Asp  Asn Ser Leu Lys Ala  Lys Gly Ala Asp Val  Val Phe Glu 
    1025                 1030                 1035             


Ser Leu  Ser Pro Phe Leu Leu  Phe Lys Gly Glu Glu  Val Gly Ala 
    1040                 1045                 1050             


Gln Ser  Leu Ser Asp Trp Gln  Glu Arg Ile Asp Gly  Arg Tyr Leu 
    1055                 1060                 1065             


Tyr Met  Ser Ile Asp Lys Val  Lys Ala Phe Asp Tyr  Leu Gln Glu 
    1070                 1075                 1080             


Lys Val  Gly Glu Lys Asp Ile  Ala Ala Glu Leu Leu  Asn Ser Ile 
    1085                 1090                 1095             


His Phe  Thr Gln Arg Lys Thr  Glu Leu Arg Ala Lys  Phe Ser Asp 
    1100                 1105                 1110             


Asp Ser  Gly Lys Lys Met Lys  Thr Leu Asp Ala Ile  Arg Lys Ser 
    1115                 1120                 1125             


Leu Lys  Leu Thr Val Thr Val  Asn Glu Ile Gly Lys  Arg Lys Glu 
    1130                 1135                 1140             


Lys Cys  Gly Phe Ser Gly Thr  Ile Gly Ile Pro Ala  Lys Ser Ala 
    1145                 1150                 1155             


Trp Glu  Asn Leu Leu Asp Glu  Pro Leu Leu Glu Thr  Tyr Trp Gly 
    1160                 1165                 1170             


Thr Lys  Met Pro Pro Gln Glu  Ile Trp Glu Lys Val  Tyr Arg Lys 
    1175                 1180                 1185             


His Phe  Pro Arg Asn Ile Pro  Asn Gln Ala His Arg  Lys Val Arg 
    1190                 1195                 1200             


Lys Asp  Phe Ser Leu Pro Val  Val Asp Ser Val Ser  Gly Gly Phe 
    1205                 1210                 1215             


Arg Val  Lys Arg Lys Thr Pro  Asn Gly Tyr Asn Tyr  Gln Leu Leu 
    1220                 1225                 1230             


Ala Ile  Asp Gly Tyr Ser Ala  Val Gly Phe Lys Lys  Glu Gly Asp 
    1235                 1240                 1245             


Asn Val  Asp Phe Lys Ser Pro  Ala Leu Val Pro Gln  Ile Ala Glu 
    1250                 1255                 1260             


Ser Lys  Ser Val Thr Pro Ile  Ser Ser Glu Leu Val  His Leu Asp 
    1265                 1270                 1275             


Lys Asn  Glu Ile Val Tyr Phe  Asp Glu Trp Arg Lys  Ile Asp Ile 
    1280                 1285                 1290             


Ser Asp  Ser Asp Leu Lys Gln  Phe Val Ser Ser Leu  Glu Leu Ala 
    1295                 1300                 1305             


Pro Gly  Ser Gln Asn Arg Phe  Tyr Ile Arg Phe Thr  Val Asp Glu 
    1310                 1315                 1320             


Asp Gln  Phe Glu Arg His Phe  Lys Ser Ala Leu Arg  Val Asn Gly 
    1325                 1330                 1335             


Ile Gln  Asp Leu Asp Thr Val  Asn Lys Thr Phe Asp  Trp Asn Arg 
    1340                 1345                 1350             


Glu Ile  Pro Ser Leu Leu Ile  Pro Pro Arg Ser Asn  Leu Phe Leu 
    1355                 1360                 1365             


Leu Glu  Thr Gly Gln Lys Ile  Thr Phe Glu Tyr Ile  Ala Asn Gly 
    1370                 1375                 1380             


Ala Asn  Ala Glu Val Lys Lys  Ala Tyr Ser Leu Arg  Arg Ala 
    1385                 1390                 1395         


<210>  770
<211>  1372
<212>  PRT
<213>  Legionella pneumophila str. Paris

<400>  770

Met Glu Ser Ser Gln Ile Leu Ser Pro Ile Gly Ile Asp Leu Gly Gly 
1               5                   10                  15      


Lys Phe Thr Gly Val Cys Leu Ser His Leu Glu Ala Phe Ala Glu Leu 
            20                  25                  30          


Pro Asn His Ala Asn Thr Lys Tyr Ser Val Ile Leu Ile Asp His Asn 
        35                  40                  45              


Asn Phe Gln Leu Ser Gln Ala Gln Arg Arg Ala Thr Arg His Arg Val 
    50                  55                  60                  


Arg Asn Lys Lys Arg Asn Gln Phe Val Lys Arg Val Ala Leu Gln Leu 
65                  70                  75                  80  


Phe Gln His Ile Leu Ser Arg Asp Leu Asn Ala Lys Glu Glu Thr Ala 
                85                  90                  95      


Leu Cys His Tyr Leu Asn Asn Arg Gly Tyr Thr Tyr Val Asp Thr Asp 
            100                 105                 110         


Leu Asp Glu Tyr Ile Lys Asp Glu Thr Thr Ile Asn Leu Leu Lys Glu 
        115                 120                 125             


Leu Leu Pro Ser Glu Ser Glu His Asn Phe Ile Asp Trp Phe Leu Gln 
    130                 135                 140                 


Lys Met Gln Ser Ser Glu Phe Arg Lys Ile Leu Val Ser Lys Val Glu 
145                 150                 155                 160 


Glu Lys Lys Asp Asp Lys Glu Leu Lys Asn Ala Val Lys Asn Ile Lys 
                165                 170                 175     


Asn Phe Ile Thr Gly Phe Glu Lys Asn Ser Val Glu Gly His Arg His 
            180                 185                 190         


Arg Lys Val Tyr Phe Glu Asn Ile Lys Ser Asp Ile Thr Lys Asp Asn 
        195                 200                 205             


Gln Leu Asp Ser Ile Lys Lys Lys Ile Pro Ser Val Cys Leu Ser Asn 
    210                 215                 220                 


Leu Leu Gly His Leu Ser Asn Leu Gln Trp Lys Asn Leu His Arg Tyr 
225                 230                 235                 240 


Leu Ala Lys Asn Pro Lys Gln Phe Asp Glu Gln Thr Phe Gly Asn Glu 
                245                 250                 255     


Phe Leu Arg Met Leu Lys Asn Phe Arg His Leu Lys Gly Ser Gln Glu 
            260                 265                 270         


Ser Leu Ala Val Arg Asn Leu Ile Gln Gln Leu Glu Gln Ser Gln Asp 
        275                 280                 285             


Tyr Ile Ser Ile Leu Glu Lys Thr Pro Pro Glu Ile Thr Ile Pro Pro 
    290                 295                 300                 


Tyr Glu Ala Arg Thr Asn Thr Gly Met Glu Lys Asp Gln Ser Leu Leu 
305                 310                 315                 320 


Leu Asn Pro Glu Lys Leu Asn Asn Leu Tyr Pro Asn Trp Arg Asn Leu 
                325                 330                 335     


Ile Pro Gly Ile Ile Asp Ala His Pro Phe Leu Glu Lys Asp Leu Glu 
            340                 345                 350         


His Thr Lys Leu Arg Asp Arg Lys Arg Ile Ile Ser Pro Ser Lys Gln 
        355                 360                 365             


Asp Glu Lys Arg Asp Ser Tyr Ile Leu Gln Arg Tyr Leu Asp Leu Asn 
    370                 375                 380                 


Lys Lys Ile Asp Lys Phe Lys Ile Lys Lys Gln Leu Ser Phe Leu Gly 
385                 390                 395                 400 


Gln Gly Lys Gln Leu Pro Ala Asn Leu Ile Glu Thr Gln Lys Glu Met 
                405                 410                 415     


Glu Thr His Phe Asn Ser Ser Leu Val Ser Val Leu Ile Gln Ile Ala 
            420                 425                 430         


Ser Ala Tyr Asn Lys Glu Arg Glu Asp Ala Ala Gln Gly Ile Trp Phe 
        435                 440                 445             


Asp Asn Ala Phe Ser Leu Cys Glu Leu Ser Asn Ile Asn Pro Pro Arg 
    450                 455                 460                 


Lys Gln Lys Ile Leu Pro Leu Leu Val Gly Ala Ile Leu Ser Glu Asp 
465                 470                 475                 480 


Phe Ile Asn Asn Lys Asp Lys Trp Ala Lys Phe Lys Ile Phe Trp Asn 
                485                 490                 495     


Thr His Lys Ile Gly Arg Thr Ser Leu Lys Ser Lys Cys Lys Glu Ile 
            500                 505                 510         


Glu Glu Ala Arg Lys Asn Ser Gly Asn Ala Phe Lys Ile Asp Tyr Glu 
        515                 520                 525             


Glu Ala Leu Asn His Pro Glu His Ser Asn Asn Lys Ala Leu Ile Lys 
    530                 535                 540                 


Ile Ile Gln Thr Ile Pro Asp Ile Ile Gln Ala Ile Gln Ser His Leu 
545                 550                 555                 560 


Gly His Asn Asp Ser Gln Ala Leu Ile Tyr His Asn Pro Phe Ser Leu 
                565                 570                 575     


Ser Gln Leu Tyr Thr Ile Leu Glu Thr Lys Arg Asp Gly Phe His Lys 
            580                 585                 590         


Asn Cys Val Ala Val Thr Cys Glu Asn Tyr Trp Arg Ser Gln Lys Thr 
        595                 600                 605             


Glu Ile Asp Pro Glu Ile Ser Tyr Ala Ser Arg Leu Pro Ala Asp Ser 
    610                 615                 620                 


Val Arg Pro Phe Asp Gly Val Leu Ala Arg Met Met Gln Arg Leu Ala 
625                 630                 635                 640 


Tyr Glu Ile Ala Met Ala Lys Trp Glu Gln Ile Lys His Ile Pro Asp 
                645                 650                 655     


Asn Ser Ser Leu Leu Ile Pro Ile Tyr Leu Glu Gln Asn Arg Phe Glu 
            660                 665                 670         


Phe Glu Glu Ser Phe Lys Lys Ile Lys Gly Ser Ser Ser Asp Lys Thr 
        675                 680                 685             


Leu Glu Gln Ala Ile Glu Lys Gln Asn Ile Gln Trp Glu Glu Lys Phe 
    690                 695                 700                 


Gln Arg Ile Ile Asn Ala Ser Met Asn Ile Cys Pro Tyr Lys Gly Ala 
705                 710                 715                 720 


Ser Ile Gly Gly Gln Gly Glu Ile Asp His Ile Tyr Pro Arg Ser Leu 
                725                 730                 735     


Ser Lys Lys His Phe Gly Val Ile Phe Asn Ser Glu Val Asn Leu Ile 
            740                 745                 750         


Tyr Cys Ser Ser Gln Gly Asn Arg Glu Lys Lys Glu Glu His Tyr Leu 
        755                 760                 765             


Leu Glu His Leu Ser Pro Leu Tyr Leu Lys His Gln Phe Gly Thr Asp 
    770                 775                 780                 


Asn Val Ser Asp Ile Lys Asn Phe Ile Ser Gln Asn Val Ala Asn Ile 
785                 790                 795                 800 


Lys Lys Tyr Ile Ser Phe His Leu Leu Thr Pro Glu Gln Gln Lys Ala 
                805                 810                 815     


Ala Arg His Ala Leu Phe Leu Asp Tyr Asp Asp Glu Ala Phe Lys Thr 
            820                 825                 830         


Ile Thr Lys Phe Leu Met Ser Gln Gln Lys Ala Arg Val Asn Gly Thr 
        835                 840                 845             


Gln Lys Phe Leu Gly Lys Gln Ile Met Glu Phe Leu Ser Thr Leu Ala 
    850                 855                 860                 


Asp Ser Lys Gln Leu Gln Leu Glu Phe Ser Ile Lys Gln Ile Thr Ala 
865                 870                 875                 880 


Glu Glu Val His Asp His Arg Glu Leu Leu Ser Lys Gln Glu Pro Lys 
                885                 890                 895     


Leu Val Lys Ser Arg Gln Gln Ser Phe Pro Ser His Ala Ile Asp Ala 
            900                 905                 910         


Thr Leu Thr Met Ser Ile Gly Leu Lys Glu Phe Pro Gln Phe Ser Gln 
        915                 920                 925             


Glu Leu Asp Asn Ser Trp Phe Ile Asn His Leu Met Pro Asp Glu Val 
    930                 935                 940                 


His Leu Asn Pro Val Arg Ser Lys Glu Lys Tyr Asn Lys Pro Asn Ile 
945                 950                 955                 960 


Ser Ser Thr Pro Leu Phe Lys Asp Ser Leu Tyr Ala Glu Arg Phe Ile 
                965                 970                 975     


Pro Val Trp Val Lys Gly Glu Thr Phe Ala Ile Gly Phe Ser Glu Lys 
            980                 985                 990         


Asp Leu Phe Glu Ile Lys Pro Ser  Asn Lys Glu Lys Leu  Phe Thr Leu 
        995                 1000                 1005             


Leu Lys  Thr Tyr Ser Thr Lys  Asn Pro Gly Glu Ser  Leu Gln Glu 
    1010                 1015                 1020             


Leu Gln  Ala Lys Ser Lys Ala  Lys Trp Leu Tyr Phe  Pro Ile Asn 
    1025                 1030                 1035             


Lys Thr  Leu Ala Leu Glu Phe  Leu His His Tyr Phe  His Lys Glu 
    1040                 1045                 1050             


Ile Val  Thr Pro Asp Asp Thr  Thr Val Cys His Phe  Ile Asn Ser 
    1055                 1060                 1065             


Leu Arg  Tyr Tyr Thr Lys Lys  Glu Ser Ile Thr Val  Lys Ile Leu 
    1070                 1075                 1080             


Lys Glu  Pro Met Pro Val Leu  Ser Val Lys Phe Glu  Ser Ser Lys 
    1085                 1090                 1095             


Lys Asn  Val Leu Gly Ser Phe  Lys His Thr Ile Ala  Leu Pro Ala 
    1100                 1105                 1110             


Thr Lys  Asp Trp Glu Arg Leu  Phe Asn His Pro Asn  Phe Leu Ala 
    1115                 1120                 1125             


Leu Lys  Ala Asn Pro Ala Pro  Asn Pro Lys Glu Phe  Asn Glu Phe 
    1130                 1135                 1140             


Ile Arg  Lys Tyr Phe Leu Ser  Asp Asn Asn Pro Asn  Ser Asp Ile 
    1145                 1150                 1155             


Pro Asn  Asn Gly His Asn Ile  Lys Pro Gln Lys His  Lys Ala Val 
    1160                 1165                 1170             


Arg Lys  Val Phe Ser Leu Pro  Val Ile Pro Gly Asn  Ala Gly Thr 
    1175                 1180                 1185             


Met Met  Arg Ile Arg Arg Lys  Asp Asn Lys Gly Gln  Pro Leu Tyr 
    1190                 1195                 1200             


Gln Leu  Gln Thr Ile Asp Asp  Thr Pro Ser Met Gly  Ile Gln Ile 
    1205                 1210                 1215             


Asn Glu  Asp Arg Leu Val Lys  Gln Glu Val Leu Met  Asp Ala Tyr 
    1220                 1225                 1230             


Lys Thr  Arg Asn Leu Ser Thr  Ile Asp Gly Ile Asn  Asn Ser Glu 
    1235                 1240                 1245             


Gly Gln  Ala Tyr Ala Thr Phe  Asp Asn Trp Leu Thr  Leu Pro Val 
    1250                 1255                 1260             


Ser Thr  Phe Lys Pro Glu Ile  Ile Lys Leu Glu Met  Lys Pro His 
    1265                 1270                 1275             


Ser Lys  Thr Arg Arg Tyr Ile  Arg Ile Thr Gln Ser  Leu Ala Asp 
    1280                 1285                 1290             


Phe Ile  Lys Thr Ile Asp Glu  Ala Leu Met Ile Lys  Pro Ser Asp 
    1295                 1300                 1305             


Ser Ile  Asp Asp Pro Leu Asn  Met Pro Asn Glu Ile  Val Cys Lys 
    1310                 1315                 1320             


Asn Lys  Leu Phe Gly Asn Glu  Leu Lys Pro Arg Asp  Gly Lys Met 
    1325                 1330                 1335             


Lys Ile  Val Ser Thr Gly Lys  Ile Val Thr Tyr Glu  Phe Glu Ser 
    1340                 1345                 1350             


Asp Ser  Thr Pro Gln Trp Ile  Gln Thr Leu Tyr Val  Thr Gln Leu 
    1355                 1360                 1365             


Lys Lys  Gln Pro 
    1370         


<210>  771
<211>  1428
<212>  PRT
<213>  Parasutterella excrementihominis YIT 11859

<400>  771

Met Gly Lys Thr His Ile Ile Gly Val Gly Leu Asp Leu Gly Gly Thr 
1               5                   10                  15      


Tyr Thr Gly Thr Phe Ile Thr Ser His Pro Ser Asp Glu Ala Glu His 
            20                  25                  30          


Arg Asp His Ser Ser Ala Phe Thr Val Val Asn Ser Glu Lys Leu Ser 
        35                  40                  45              


Phe Ser Ser Lys Ser Arg Thr Ala Val Arg His Arg Val Arg Ser Tyr 
    50                  55                  60                  


Lys Gly Phe Asp Leu Arg Arg Arg Leu Leu Leu Leu Val Ala Glu Tyr 
65                  70                  75                  80  


Gln Leu Leu Gln Lys Lys Gln Thr Leu Ala Pro Glu Glu Arg Glu Asn 
                85                  90                  95      


Leu Arg Ile Ala Leu Ser Gly Tyr Leu Lys Arg Arg Gly Tyr Ala Arg 
            100                 105                 110         


Thr Glu Ala Glu Thr Asp Thr Ser Val Leu Glu Ser Leu Asp Pro Ser 
        115                 120                 125             


Val Phe Ser Ser Ala Pro Ser Phe Thr Asn Phe Phe Asn Asp Ser Glu 
    130                 135                 140                 


Pro Leu Asn Ile Gln Trp Glu Ala Ile Ala Asn Ser Pro Glu Thr Thr 
145                 150                 155                 160 


Lys Ala Leu Asn Lys Glu Leu Ser Gly Gln Lys Glu Ala Asp Phe Lys 
                165                 170                 175     


Lys Tyr Ile Lys Thr Ser Phe Pro Glu Tyr Ser Ala Lys Glu Ile Leu 
            180                 185                 190         


Ala Asn Tyr Val Glu Gly Arg Arg Ala Ile Leu Asp Ala Ser Lys Tyr 
        195                 200                 205             


Ile Ala Asn Leu Gln Ser Leu Gly His Lys His Arg Ser Lys Tyr Leu 
    210                 215                 220                 


Ser Asp Ile Leu Gln Asp Met Lys Arg Asp Ser Arg Ile Thr Arg Leu 
225                 230                 235                 240 


Ser Glu Ala Phe Gly Ser Thr Asp Asn Leu Trp Arg Ile Ile Gly Asn 
                245                 250                 255     


Ile Ser Asn Leu Gln Glu Arg Ala Val Arg Trp Tyr Phe Asn Asp Ala 
            260                 265                 270         


Lys Phe Glu Gln Gly Gln Glu Gln Leu Asp Ala Val Lys Leu Lys Asn 
        275                 280                 285             


Val Leu Val Arg Ala Leu Lys Tyr Leu Arg Ser Asp Asp Lys Glu Trp 
    290                 295                 300                 


Ser Ala Ser Gln Lys Gln Ile Ile Gln Ser Leu Glu Gln Ser Gly Asp 
305                 310                 315                 320 


Val Leu Asp Val Leu Ala Gly Leu Asp Pro Asp Arg Thr Ile Pro Pro 
                325                 330                 335     


Tyr Glu Asp Gln Asn Asn Arg Arg Pro Pro Glu Asp Gln Thr Leu Tyr 
            340                 345                 350         


Leu Asn Pro Lys Ala Leu Ser Ser Glu Tyr Gly Glu Lys Trp Lys Ser 
        355                 360                 365             


Trp Ala Asn Lys Phe Ala Gly Ala Tyr Pro Leu Leu Thr Glu Asp Leu 
    370                 375                 380                 


Thr Glu Ile Leu Lys Asn Thr Asp Arg Lys Ser Arg Ile Lys Ile Arg 
385                 390                 395                 400 


Ser Asp Val Leu Pro Asp Ser Asp Tyr Arg Leu Ala Tyr Ile Leu Gln 
                405                 410                 415     


Arg Ala Phe Asp Arg Ser Ile Ala Leu Asp Glu Cys Ser Ile Arg Arg 
            420                 425                 430         


Thr Ala Glu Asp Phe Glu Asn Gly Val Val Ile Lys Asn Glu Lys Leu 
        435                 440                 445             


Glu Asp Val Leu Ser Gly His Gln Leu Glu Glu Phe Leu Glu Phe Ala 
    450                 455                 460                 


Asn Arg Tyr Tyr Gln Glu Thr Ala Lys Ala Lys Asn Gly Leu Trp Phe 
465                 470                 475                 480 


Pro Glu Asn Ala Leu Leu Glu Arg Ala Asp Leu His Pro Pro Met Lys 
                485                 490                 495     


Asn Lys Ile Leu Asn Val Ile Val Gly Gln Ala Leu Gly Val Ser Pro 
            500                 505                 510         


Ala Glu Gly Thr Asp Phe Ile Glu Glu Ile Trp Asn Ser Lys Val Lys 
        515                 520                 525             


Gly Arg Ser Thr Val Arg Ser Ile Cys Asn Ala Ile Glu Asn Glu Arg 
    530                 535                 540                 


Lys Thr Tyr Gly Pro Tyr Phe Ser Glu Asp Tyr Lys Phe Val Lys Thr 
545                 550                 555                 560 


Ala Leu Lys Glu Gly Lys Thr Glu Lys Glu Leu Ser Lys Lys Phe Ala 
                565                 570                 575     


Ala Val Ile Lys Val Leu Lys Met Val Ser Glu Val Val Pro Phe Ile 
            580                 585                 590         


Gly Lys Glu Leu Arg Leu Ser Asp Glu Ala Gln Ser Lys Phe Asp Asn 
        595                 600                 605             


Leu Tyr Ser Leu Ala Gln Leu Tyr Asn Leu Ile Glu Thr Glu Arg Asn 
    610                 615                 620                 


Gly Phe Ser Lys Val Ser Leu Ala Ala His Leu Glu Asn Ala Trp Arg 
625                 630                 635                 640 


Met Thr Met Thr Asp Gly Ser Ala Gln Cys Cys Arg Leu Pro Ala Asp 
                645                 650                 655     


Cys Val Arg Pro Phe Asp Gly Phe Ile Arg Lys Ala Ile Asp Arg Asn 
            660                 665                 670         


Ser Trp Glu Val Ala Lys Arg Ile Ala Glu Glu Val Lys Lys Ser Val 
        675                 680                 685             


Asp Phe Thr Asn Gly Thr Val Lys Ile Pro Val Ala Ile Glu Ala Asn 
    690                 695                 700                 


Ser Phe Asn Phe Thr Ala Ser Leu Thr Asp Leu Lys Tyr Ile Gln Leu 
705                 710                 715                 720 


Lys Glu Gln Lys Leu Lys Lys Lys Leu Glu Asp Ile Gln Arg Asn Glu 
                725                 730                 735     


Glu Asn Gln Glu Lys Arg Trp Leu Ser Lys Glu Glu Arg Ile Arg Ala 
            740                 745                 750         


Asp Ser His Gly Ile Cys Ala Tyr Thr Gly Arg Pro Leu Asp Asp Val 
        755                 760                 765             


Gly Glu Ile Asp His Ile Ile Pro Arg Ser Leu Thr Leu Lys Lys Ser 
    770                 775                 780                 


Glu Ser Ile Tyr Asn Ser Glu Val Asn Leu Ile Phe Val Ser Ala Gln 
785                 790                 795                 800 


Gly Asn Gln Glu Lys Lys Asn Asn Ile Tyr Leu Leu Ser Asn Leu Ala 
                805                 810                 815     


Lys Asn Tyr Leu Ala Ala Val Phe Gly Thr Ser Asp Leu Ser Gln Ile 
            820                 825                 830         


Thr Asn Glu Ile Glu Ser Thr Val Leu Gln Leu Lys Ala Ala Gly Arg 
        835                 840                 845             


Leu Gly Tyr Phe Asp Leu Leu Ser Glu Lys Glu Arg Ala Cys Ala Arg 
    850                 855                 860                 


His Ala Leu Phe Leu Asn Ser Asp Ser Glu Ala Arg Arg Ala Val Ile 
865                 870                 875                 880 


Asp Val Leu Gly Ser Arg Arg Lys Ala Ser Val Asn Gly Thr Gln Ala 
                885                 890                 895     


Trp Phe Val Arg Ser Ile Phe Ser Lys Val Arg Gln Ala Leu Ala Ala 
            900                 905                 910         


Trp Thr Gln Glu Thr Gly Asn Glu Leu Ile Phe Asp Ala Ile Ser Val 
        915                 920                 925             


Pro Ala Ala Asp Ser Ser Glu Met Arg Lys Arg Phe Ala Glu Tyr Arg 
    930                 935                 940                 


Pro Glu Phe Arg Lys Pro Lys Val Gln Pro Val Ala Ser His Ser Ile 
945                 950                 955                 960 


Asp Ala Met Cys Ile Tyr Leu Ala Ala Cys Ser Asp Pro Phe Lys Thr 
                965                 970                 975     


Lys Arg Met Gly Ser Gln Leu Ala Ile Tyr Glu Pro Ile Asn Phe Asp 
            980                 985                 990         


Asn Leu Phe Thr Gly Ser Cys Gln  Val Ile Gln Asn Thr  Pro Arg Asn 
        995                 1000                 1005             


Phe Ser  Asp Lys Thr Asn Ile  Ala Asn Ser Pro Ile  Phe Lys Glu 
    1010                 1015                 1020             


Thr Ile  Tyr Ala Glu Arg Phe  Leu Asp Ile Ile Val  Ser Arg Gly 
    1025                 1030                 1035             


Glu Ile  Phe Ile Gly Tyr Pro  Ser Asn Met Pro Phe  Glu Glu Lys 
    1040                 1045                 1050             


Pro Asn  Arg Ile Ser Ile Gly  Gly Lys Asp Pro Phe  Ser Ile Leu 
    1055                 1060                 1065             


Ser Val  Leu Gly Ala Tyr Leu  Asp Lys Ala Pro Ser  Ser Glu Lys 
    1070                 1075                 1080             


Glu Lys  Leu Thr Ile Tyr Arg  Val Val Lys Asn Lys  Ala Phe Glu 
    1085                 1090                 1095             


Leu Phe  Ser Lys Val Ala Gly  Ser Lys Phe Thr Ala  Glu Glu Asp 
    1100                 1105                 1110             


Lys Ala  Ala Lys Ile Leu Glu  Ala Leu His Phe Val  Thr Val Lys 
    1115                 1120                 1125             


Gln Asp  Val Ala Ala Thr Val  Ser Asp Leu Ile Lys  Ser Lys Lys 
    1130                 1135                 1140             


Glu Leu  Ser Lys Asp Ser Ile  Glu Asn Leu Ala Lys  Gln Lys Gly 
    1145                 1150                 1155             


Cys Leu  Lys Lys Val Glu Tyr  Ser Ser Lys Glu Phe  Lys Phe Lys 
    1160                 1165                 1170             


Gly Ser  Leu Ile Ile Pro Ala  Ala Val Glu Trp Gly  Lys Val Leu 
    1175                 1180                 1185             


Trp Asn  Val Phe Lys Glu Asn  Thr Ala Glu Glu Leu  Lys Asp Glu 
    1190                 1195                 1200             


Asn Ala  Leu Arg Lys Ala Leu  Glu Ala Ala Trp Pro  Ser Ser Phe 
    1205                 1210                 1215             


Gly Thr  Arg Asn Leu His Ser  Lys Ala Lys Arg Val  Phe Ser Leu 
    1220                 1225                 1230             


Pro Val  Val Ala Thr Gln Ser  Gly Ala Val Arg Ile  Arg Arg Lys 
    1235                 1240                 1245             


Thr Ala  Phe Gly Asp Phe Val  Tyr Gln Ser Gln Asp  Thr Asn Asn 
    1250                 1255                 1260             


Leu Tyr  Ser Ser Phe Pro Val  Lys Asn Gly Lys Leu  Asp Trp Ser 
    1265                 1270                 1275             


Ser Pro  Ile Ile His Pro Ala  Leu Gln Asn Arg Asn  Leu Thr Ala 
    1280                 1285                 1290             


Tyr Gly  Tyr Arg Phe Val Asp  His Asp Arg Ser Ile  Ser Met Ser 
    1295                 1300                 1305             


Glu Phe  Arg Glu Val Tyr Asn  Lys Asp Asp Leu Met  Arg Ile Glu 
    1310                 1315                 1320             


Leu Ala  Gln Gly Thr Ser Ser  Arg Arg Tyr Leu Arg  Val Glu Met 
    1325                 1330                 1335             


Pro Gly  Glu Lys Phe Leu Ala  Trp Phe Gly Glu Asn  Ser Ile Ser 
    1340                 1345                 1350             


Leu Gly  Ser Ser Phe Lys Phe  Ser Val Ser Glu Val  Phe Asp Asn 
    1355                 1360                 1365             


Lys Ile  Tyr Thr Glu Asn Ala  Glu Phe Thr Lys Phe  Leu Pro Lys 
    1370                 1375                 1380             


Pro Arg  Glu Asp Asn Lys His  Asn Gly Thr Ile Phe  Phe Glu Leu 
    1385                 1390                 1395             


Val Gly  Pro Arg Val Ile Phe  Asn Tyr Ile Val Gly  Gly Ala Ala 
    1400                 1405                 1410             


Ser Ser  Leu Lys Glu Ile Phe  Ser Glu Ala Gly Lys  Glu Arg Ser 
    1415                 1420                 1425             


<210>  772
<211>  1409
<212>  PRT
<213>  Wolinella succinogenes DSM 1740

<400>  772

Met Leu Val Ser Pro Ile Ser Val Asp Leu Gly Gly Lys Asn Thr Gly 
1               5                   10                  15      


Phe Phe Ser Phe Thr Asp Ser Leu Asp Asn Ser Gln Ser Gly Thr Val 
            20                  25                  30          


Ile Tyr Asp Glu Ser Phe Val Leu Ser Gln Val Gly Arg Arg Ser Lys 
        35                  40                  45              


Arg His Ser Lys Arg Asn Asn Leu Arg Asn Lys Leu Val Lys Arg Leu 
    50                  55                  60                  


Phe Leu Leu Ile Leu Gln Glu His His Gly Leu Ser Ile Asp Val Leu 
65                  70                  75                  80  


Pro Asp Glu Ile Arg Gly Leu Phe Asn Lys Arg Gly Tyr Thr Tyr Ala 
                85                  90                  95      


Gly Phe Glu Leu Asp Glu Lys Lys Lys Asp Ala Leu Glu Ser Asp Thr 
            100                 105                 110         


Leu Lys Glu Phe Leu Ser Glu Lys Leu Gln Ser Ile Asp Arg Asp Ser 
        115                 120                 125             


Asp Val Glu Asp Phe Leu Asn Gln Ile Ala Ser Asn Ala Glu Ser Phe 
    130                 135                 140                 


Lys Asp Tyr Lys Lys Gly Phe Glu Ala Val Phe Ala Ser Ala Thr His 
145                 150                 155                 160 


Ser Pro Asn Lys Lys Leu Glu Leu Lys Asp Glu Leu Lys Ser Glu Tyr 
                165                 170                 175     


Gly Glu Asn Ala Lys Glu Leu Leu Ala Gly Leu Arg Val Thr Lys Glu 
            180                 185                 190         


Ile Leu Asp Glu Phe Asp Lys Gln Glu Asn Gln Gly Asn Leu Pro Arg 
        195                 200                 205             


Ala Lys Tyr Phe Glu Glu Leu Gly Glu Tyr Ile Ala Thr Asn Glu Lys 
    210                 215                 220                 


Val Lys Ser Phe Phe Asp Ser Asn Ser Leu Lys Leu Thr Asp Met Thr 
225                 230                 235                 240 


Lys Leu Ile Gly Asn Ile Ser Asn Tyr Gln Leu Lys Glu Leu Arg Arg 
                245                 250                 255     


Tyr Phe Asn Asp Lys Glu Met Glu Lys Gly Asp Ile Trp Ile Pro Asn 
            260                 265                 270         


Lys Leu His Lys Ile Thr Glu Arg Phe Val Arg Ser Trp His Pro Lys 
        275                 280                 285             


Asn Asp Ala Asp Arg Gln Arg Arg Ala Glu Leu Met Lys Asp Leu Lys 
    290                 295                 300                 


Ser Lys Glu Ile Met Glu Leu Leu Thr Thr Thr Glu Pro Val Met Thr 
305                 310                 315                 320 


Ile Pro Pro Tyr Asp Asp Met Asn Asn Arg Gly Ala Val Lys Cys Gln 
                325                 330                 335     


Thr Leu Arg Leu Asn Glu Glu Tyr Leu Asp Lys His Leu Pro Asn Trp 
            340                 345                 350         


Arg Asp Ile Ala Lys Arg Leu Asn His Gly Lys Phe Asn Asp Asp Leu 
        355                 360                 365             


Ala Asp Ser Thr Val Lys Gly Tyr Ser Glu Asp Ser Thr Leu Leu His 
    370                 375                 380                 


Arg Leu Leu Asp Thr Ser Lys Glu Ile Asp Ile Tyr Glu Leu Arg Gly 
385                 390                 395                 400 


Lys Lys Pro Asn Glu Leu Leu Val Lys Thr Leu Gly Gln Ser Asp Ala 
                405                 410                 415     


Asn Arg Leu Tyr Gly Phe Ala Gln Asn Tyr Tyr Glu Leu Ile Arg Gln 
            420                 425                 430         


Lys Val Arg Ala Gly Ile Trp Val Pro Val Lys Asn Lys Asp Asp Ser 
        435                 440                 445             


Leu Asn Leu Glu Asp Asn Ser Asn Met Leu Lys Arg Cys Asn His Asn 
    450                 455                 460                 


Pro Pro His Lys Lys Asn Gln Ile His Asn Leu Val Ala Gly Ile Leu 
465                 470                 475                 480 


Gly Val Lys Leu Asp Glu Ala Lys Phe Ala Glu Phe Glu Lys Glu Leu 
                485                 490                 495     


Trp Ser Ala Lys Val Gly Asn Lys Lys Leu Ser Ala Tyr Cys Lys Asn 
            500                 505                 510         


Ile Glu Glu Leu Arg Lys Thr His Gly Asn Thr Phe Lys Ile Asp Ile 
        515                 520                 525             


Glu Glu Leu Arg Lys Lys Asp Pro Ala Glu Leu Ser Lys Glu Glu Lys 
    530                 535                 540                 


Ala Lys Leu Arg Leu Thr Asp Asp Val Ile Leu Asn Glu Trp Ser Gln 
545                 550                 555                 560 


Lys Ile Ala Asn Phe Phe Asp Ile Asp Asp Lys His Arg Gln Arg Phe 
                565                 570                 575     


Asn Asn Leu Phe Ser Met Ala Gln Leu His Thr Val Ile Asp Thr Pro 
            580                 585                 590         


Arg Ser Gly Phe Ser Ser Thr Cys Lys Arg Cys Thr Ala Glu Asn Arg 
        595                 600                 605             


Phe Arg Ser Glu Thr Ala Phe Tyr Asn Asp Glu Thr Gly Glu Phe His 
    610                 615                 620                 


Lys Lys Ala Thr Ala Thr Cys Gln Arg Leu Pro Ala Asp Thr Gln Arg 
625                 630                 635                 640 


Pro Phe Ser Gly Lys Ile Glu Arg Tyr Ile Asp Lys Leu Gly Tyr Glu 
                645                 650                 655     


Leu Ala Lys Ile Lys Ala Lys Glu Leu Glu Gly Met Glu Ala Lys Glu 
            660                 665                 670         


Ile Lys Val Pro Ile Ile Leu Glu Gln Asn Ala Phe Glu Tyr Glu Glu 
        675                 680                 685             


Ser Leu Arg Lys Ser Lys Thr Gly Ser Asn Asp Arg Val Ile Asn Ser 
    690                 695                 700                 


Lys Lys Asp Arg Asp Gly Lys Lys Leu Ala Lys Ala Lys Glu Asn Ala 
705                 710                 715                 720 


Glu Asp Arg Leu Lys Asp Lys Asp Lys Arg Ile Lys Ala Phe Ser Ser 
                725                 730                 735     


Gly Ile Cys Pro Tyr Cys Gly Asp Thr Ile Gly Asp Asp Gly Glu Ile 
            740                 745                 750         


Asp His Ile Leu Pro Arg Ser His Thr Leu Lys Ile Tyr Gly Thr Val 
        755                 760                 765             


Phe Asn Pro Glu Gly Asn Leu Ile Tyr Val His Gln Lys Cys Asn Gln 
    770                 775                 780                 


Ala Lys Ala Asp Ser Ile Tyr Lys Leu Ser Asp Ile Lys Ala Gly Val 
785                 790                 795                 800 


Ser Ala Gln Trp Ile Glu Glu Gln Val Ala Asn Ile Lys Gly Tyr Lys 
                805                 810                 815     


Thr Phe Ser Val Leu Ser Ala Glu Gln Gln Lys Ala Phe Arg Tyr Ala 
            820                 825                 830         


Leu Phe Leu Gln Asn Asp Asn Glu Ala Tyr Lys Lys Val Val Asp Trp 
        835                 840                 845             


Leu Arg Thr Asp Gln Ser Ala Arg Val Asn Gly Thr Gln Lys Tyr Leu 
    850                 855                 860                 


Ala Lys Lys Ile Gln Glu Lys Leu Thr Lys Met Leu Pro Asn Lys His 
865                 870                 875                 880 


Leu Ser Phe Glu Phe Ile Leu Ala Asp Ala Thr Glu Val Ser Glu Leu 
                885                 890                 895     


Arg Arg Gln Tyr Ala Arg Gln Asn Pro Leu Leu Ala Lys Ala Glu Lys 
            900                 905                 910         


Gln Ala Pro Ser Ser His Ala Ile Asp Ala Val Met Ala Phe Val Ala 
        915                 920                 925             


Arg Tyr Gln Lys Val Phe Lys Asp Gly Thr Pro Pro Asn Ala Asp Glu 
    930                 935                 940                 


Val Ala Lys Leu Ala Met Leu Asp Ser Trp Asn Pro Ala Ser Asn Glu 
945                 950                 955                 960 


Pro Leu Thr Lys Gly Leu Ser Thr Asn Gln Lys Ile Glu Lys Met Ile 
                965                 970                 975     


Lys Ser Gly Asp Tyr Gly Gln Lys Asn Met Arg Glu Val Phe Gly Lys 
            980                 985                 990         


Ser Ile Phe Gly Glu Asn Ala Ile  Gly Glu Arg Tyr Lys  Pro Ile Val 
        995                 1000                 1005             


Val Gln  Glu Gly Gly Tyr Tyr  Ile Gly Tyr Pro Ala  Thr Val Lys 
    1010                 1015                 1020             


Lys Gly  Tyr Glu Leu Lys Asn  Cys Lys Val Val Thr  Ser Lys Asn 
    1025                 1030                 1035             


Asp Ile  Ala Lys Leu Glu Lys  Ile Ile Lys Asn Gln  Asp Leu Ile 
    1040                 1045                 1050             


Ser Leu  Lys Glu Asn Gln Tyr  Ile Lys Ile Phe Ser  Ile Asn Lys 
    1055                 1060                 1065             


Gln Thr  Ile Ser Glu Leu Ser  Asn Arg Tyr Phe Asn  Met Asn Tyr 
    1070                 1075                 1080             


Lys Asn  Leu Val Glu Arg Asp  Lys Glu Ile Val Gly  Leu Leu Glu 
    1085                 1090                 1095             


Phe Ile  Val Glu Asn Cys Arg  Tyr Tyr Thr Lys Lys  Val Asp Val 
    1100                 1105                 1110             


Lys Phe  Ala Pro Lys Tyr Ile  His Glu Thr Lys Tyr  Pro Phe Tyr 
    1115                 1120                 1125             


Asp Asp  Trp Arg Arg Phe Asp  Glu Ala Trp Arg Tyr  Leu Gln Glu 
    1130                 1135                 1140             


Asn Gln  Asn Lys Thr Ser Ser  Lys Asp Arg Phe Val  Ile Asp Lys 
    1145                 1150                 1155             


Ser Ser  Leu Asn Glu Tyr Tyr  Gln Pro Asp Lys Asn  Glu Tyr Lys 
    1160                 1165                 1170             


Leu Asp  Val Asp Thr Gln Pro  Ile Trp Asp Asp Phe  Cys Arg Trp 
    1175                 1180                 1185             


Tyr Phe  Leu Asp Arg Tyr Lys  Thr Ala Asn Asp Lys  Lys Ser Ile 
    1190                 1195                 1200             


Arg Ile  Lys Ala Arg Lys Thr  Phe Ser Leu Leu Ala  Glu Ser Gly 
    1205                 1210                 1215             


Val Gln  Gly Lys Val Phe Arg  Ala Lys Arg Lys Ile  Pro Thr Gly 
    1220                 1225                 1230             


Tyr Ala  Tyr Gln Ala Leu Pro  Met Asp Asn Asn Val  Ile Ala Gly 
    1235                 1240                 1245             


Asp Tyr  Ala Asn Ile Leu Leu  Glu Ala Asn Ser Lys  Thr Leu Ser 
    1250                 1255                 1260             


Leu Val  Pro Lys Ser Gly Ile  Ser Ile Glu Lys Gln  Leu Asp Lys 
    1265                 1270                 1275             


Lys Leu  Asp Val Ile Lys Lys  Thr Asp Val Arg Gly  Leu Ala Ile 
    1280                 1285                 1290             


Asp Asn  Asn Ser Phe Phe Asn  Ala Asp Phe Asp Thr  His Gly Ile 
    1295                 1300                 1305             


Arg Leu  Ile Val Glu Asn Thr  Ser Val Lys Val Gly  Asn Phe Pro 
    1310                 1315                 1320             


Ile Ser  Ala Ile Asp Lys Ser  Ala Lys Arg Met Ile  Phe Arg Ala 
    1325                 1330                 1335             


Leu Phe  Glu Lys Glu Lys Gly  Lys Arg Lys Lys Lys  Thr Thr Ile 
    1340                 1345                 1350             


Ser Phe  Lys Glu Ser Gly Pro  Val Gln Asp Tyr Leu  Lys Val Phe 
    1355                 1360                 1365             


Leu Lys  Lys Ile Val Lys Ile  Gln Leu Arg Thr Asp  Gly Ser Ile 
    1370                 1375                 1380             


Ser Asn  Ile Val Val Arg Lys  Asn Ala Ala Asp Phe  Thr Leu Ser 
    1385                 1390                 1395             


Phe Arg  Ser Glu His Ile Gln  Lys Leu Leu Lys 
    1400                 1405                 


<210>  773
<211>  1629
<212>  PRT
<213>  Francisella novicida U112

<400>  773

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  774
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of artificial sequence: Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (25)..(25)
<223>  n is a, c, t, g, uknown or other

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n is a, c, g, or t

<400>  774
gataatctct tatagaattg aaagngg                                           27


<210>  775
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of artificial sequence: Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (25)..(25)
<223>  n is a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n is a, c, g, or t

<400>  775
gttaatcttc tatagagttg aaagngg                                           27


<210>  776
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of artificial sequence: Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (31)..(31)
<223>  n is a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  n is a, c, g, or t

<400>  776
gttaaaatca gaccaaaatg ggattgaaat ngg                                    33


<210>  777
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of artificial sequence: Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (30)..(30)
<223>  n is a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  n is a, c, g, or t

<400>  777
gttttaacta cttattatga aatctaaatn gg                                     32


<210>  778
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of artificial sequence: Synthetic oligonucleotide

<400>  778
gtctcaccct tcatgggtga gtggattgaa atgaa                                  35


<210>  779
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of artificial sequence: Synthetic oligonucleotide

<400>  779
gtcgcgtcct cacgggcgcg tggattgaaa cgaa                                   34


<210>  780
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of artificial sequence: Synthetic oligonucleotide

<400>  780
gwgttccccg cgccagcggg gataaaccgc tt                                     32


<210>  781
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of artificial sequence: Synthetic oligonucleotide

<400>  781
gtgttcccca catgcgtggg gatgaaccgc tt                                     32


<210>  782
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of artificial sequence: Synthetic oligonucleotide

<400>  782
gwgttccccg cgccagcggg gataaaccgc at                                     32


<210>  783
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of artificial sequence: Synthetic oligonucleotide

<400>  783
gwgttccccg cgccagcggg gataaaccgc ct                                     32


<210>  784
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of artificial sequence: Synthetic oligonucleotide

<400>  784
gwgttccccg cgccagcggg gataaaccgc tc                                     32


<210>  785
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of artificial sequence: Synthetic oligonucleotide

<400>  785
gttcactgcc gtgtaggcag ctaagaaagg                                        30


<210>  786
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of artificial sequence: Synthetic oligonucleotide

<400>  786
gttcaccgcc gcacaggcgg cttagaaagg                                        30


<210>  787
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of artificial sequence: Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (6)..(7)
<223>  n is a, c, t, g, unknown, or other

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  n is a, c, g, or t

<400>  787
wttctnngtt tttgtactct caagatttaa gtaactgtac aac                         43


<210>  788
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of artificial sequence: Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (6)..(8)
<223>  n is a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  n is a, c, g, or t

<400>  788
tttyrnnngt ttttgtactc tcaagattta agtaactgta caac                        44


<210>  789
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of artificial sequence: Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n is a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is a, c, g, or t

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n is a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is a, c, g, or t

<400>  789
cnccngtttt agagctgtgt tgtttcgaat ggttccaaaa c                           41


<210>  790
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of artificial sequence: Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (3)..(3)
<223>  n is a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is a, c, g, or t

<400>  790
ccngttttag agctatgctg ttttgaatgg tcccaaaac                              39


<210>  791
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of artificial sequence: Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (3)..(3)
<223>  n is a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is a, c, g, or t

<400>  791
ccngttttag agctatgtta ttttgaatgc taccaaaac                              39


