                         SEQUENCE LISTING

<110>  MEDIMMUNE LLC
 
<120>  Dipeptidyl Peptidase-4 and Periostin as Predictors of Clinical Response to Eosinophil-Targeted 
       Eosinophil-Targeted Therapeutic Agents in Eosinophilic Diseases

<130>  IL5R-400P1

<160>  20    

<170>  PatentIn version 3.5


<210>  1
<211>  766
<212>  PRT
<213>  Homo sapiens

<220>
<221>  misc_feature
<222>  (1)..(766)
<223>  DPP4 membrane bound form

<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  cytoplasmic domain

<220>
<221>  misc_feature
<222>  (7)..(28)
<223>  transmembrane helix

<220>
<221>  misc_feature
<222>  (29)..(766)
<223>  extracellular domain

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  cleavage site to yield soluble form

<400>  1

Met Lys Thr Pro Trp Lys Val Leu Leu Gly Leu Leu Gly Ala Ala Ala 
1               5                   10                  15      


Leu Val Thr Ile Ile Thr Val Pro Val Val Leu Leu Asn Lys Gly Thr 
            20                  25                  30          


Asp Asp Ala Thr Ala Asp Ser Arg Lys Thr Tyr Thr Leu Thr Asp Tyr 
        35                  40                  45              


Leu Lys Asn Thr Tyr Arg Leu Lys Leu Tyr Ser Leu Arg Trp Ile Ser 
    50                  55                  60                  


Asp His Glu Tyr Leu Tyr Lys Gln Glu Asn Asn Ile Leu Val Phe Asn 
65                  70                  75                  80  


Ala Glu Tyr Gly Asn Ser Ser Val Phe Leu Glu Asn Ser Thr Phe Asp 
                85                  90                  95      


Glu Phe Gly His Ser Ile Asn Asp Tyr Ser Ile Ser Pro Asp Gly Gln 
            100                 105                 110         


Phe Ile Leu Leu Glu Tyr Asn Tyr Val Lys Gln Trp Arg His Ser Tyr 
        115                 120                 125             


Thr Ala Ser Tyr Asp Ile Tyr Asp Leu Asn Lys Arg Gln Leu Ile Thr 
    130                 135                 140                 


Glu Glu Arg Ile Pro Asn Asn Thr Gln Trp Val Thr Trp Ser Pro Val 
145                 150                 155                 160 


Gly His Lys Leu Ala Tyr Val Trp Asn Asn Asp Ile Tyr Val Lys Ile 
                165                 170                 175     


Glu Pro Asn Leu Pro Ser Tyr Arg Ile Thr Trp Thr Gly Lys Glu Asp 
            180                 185                 190         


Ile Ile Tyr Asn Gly Ile Thr Asp Trp Val Tyr Glu Glu Glu Val Phe 
        195                 200                 205             


Ser Ala Tyr Ser Ala Leu Trp Trp Ser Pro Asn Gly Thr Phe Leu Ala 
    210                 215                 220                 


Tyr Ala Gln Phe Asn Asp Thr Glu Val Pro Leu Ile Glu Tyr Ser Phe 
225                 230                 235                 240 


Tyr Ser Asp Glu Ser Leu Gln Tyr Pro Lys Thr Val Arg Val Pro Tyr 
                245                 250                 255     


Pro Lys Ala Gly Ala Val Asn Pro Thr Val Lys Phe Phe Val Val Asn 
            260                 265                 270         


Thr Asp Ser Leu Ser Ser Val Thr Asn Ala Thr Ser Ile Gln Ile Thr 
        275                 280                 285             


Ala Pro Ala Ser Met Leu Ile Gly Asp His Tyr Leu Cys Asp Val Thr 
    290                 295                 300                 


Trp Ala Thr Gln Glu Arg Ile Ser Leu Gln Trp Leu Arg Arg Ile Gln 
305                 310                 315                 320 


Asn Tyr Ser Val Met Asp Ile Cys Asp Tyr Asp Glu Ser Ser Gly Arg 
                325                 330                 335     


Trp Asn Cys Leu Val Ala Arg Gln His Ile Glu Met Ser Thr Thr Gly 
            340                 345                 350         


Trp Val Gly Arg Phe Arg Pro Ser Glu Pro His Phe Thr Leu Asp Gly 
        355                 360                 365             


Asn Ser Phe Tyr Lys Ile Ile Ser Asn Glu Glu Gly Tyr Arg His Ile 
    370                 375                 380                 


Cys Tyr Phe Gln Ile Asp Lys Lys Asp Cys Thr Phe Ile Thr Lys Gly 
385                 390                 395                 400 


Thr Trp Glu Val Ile Gly Ile Glu Ala Leu Thr Ser Asp Tyr Leu Tyr 
                405                 410                 415     


Tyr Ile Ser Asn Glu Tyr Lys Gly Met Pro Gly Gly Arg Asn Leu Tyr 
            420                 425                 430         


Lys Ile Gln Leu Ser Asp Tyr Thr Lys Val Thr Cys Leu Ser Cys Glu 
        435                 440                 445             


Leu Asn Pro Glu Arg Cys Gln Tyr Tyr Ser Val Ser Phe Ser Lys Glu 
    450                 455                 460                 


Ala Lys Tyr Tyr Gln Leu Arg Cys Ser Gly Pro Gly Leu Pro Leu Tyr 
465                 470                 475                 480 


Thr Leu His Ser Ser Val Asn Asp Lys Gly Leu Arg Val Leu Glu Asp 
                485                 490                 495     


Asn Ser Ala Leu Asp Lys Met Leu Gln Asn Val Gln Met Pro Ser Lys 
            500                 505                 510         


Lys Leu Asp Phe Ile Ile Leu Asn Glu Thr Lys Phe Trp Tyr Gln Met 
        515                 520                 525             


Ile Leu Pro Pro His Phe Asp Lys Ser Lys Lys Tyr Pro Leu Leu Leu 
    530                 535                 540                 


Asp Val Tyr Ala Gly Pro Cys Ser Gln Lys Ala Asp Thr Val Phe Arg 
545                 550                 555                 560 


Leu Asn Trp Ala Thr Tyr Leu Ala Ser Thr Glu Asn Ile Ile Val Ala 
                565                 570                 575     


Ser Phe Asp Gly Arg Gly Ser Gly Tyr Gln Gly Asp Lys Ile Met His 
            580                 585                 590         


Ala Ile Asn Arg Arg Leu Gly Thr Phe Glu Val Glu Asp Gln Ile Glu 
        595                 600                 605             


Ala Ala Arg Gln Phe Ser Lys Met Gly Phe Val Asp Asn Lys Arg Ile 
    610                 615                 620                 


Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Thr Ser Met Val Leu 
625                 630                 635                 640 


Gly Ser Gly Ser Gly Val Phe Lys Cys Gly Ile Ala Val Ala Pro Val 
                645                 650                 655     


Ser Arg Trp Glu Tyr Tyr Asp Ser Val Tyr Thr Glu Arg Tyr Met Gly 
            660                 665                 670         


Leu Pro Thr Pro Glu Asp Asn Leu Asp His Tyr Arg Asn Ser Thr Val 
        675                 680                 685             


Met Ser Arg Ala Glu Asn Phe Lys Gln Val Glu Tyr Leu Leu Ile His 
    690                 695                 700                 


Gly Thr Ala Asp Asp Asn Val His Phe Gln Gln Ser Ala Gln Ile Ser 
705                 710                 715                 720 


Lys Ala Leu Val Asp Val Gly Val Asp Phe Gln Ala Met Trp Tyr Thr 
                725                 730                 735     


Asp Glu Asp His Gly Ile Ala Ser Ser Thr Ala His Gln His Ile Tyr 
            740                 745                 750         


Thr His Met Ser His Phe Ile Lys Gln Cys Phe Ser Leu Pro 
        755                 760                 765     


<210>  2
<211>  728
<212>  PRT
<213>  Homo sapiens

<220>
<221>  misc_feature
<222>  (1)..(728)
<223>  DPP4 soluble form

<400>  2

Ser Arg Lys Thr Tyr Thr Leu Thr Asp Tyr Leu Lys Asn Thr Tyr Arg 
1               5                   10                  15      


Leu Lys Leu Tyr Ser Leu Arg Trp Ile Ser Asp His Glu Tyr Leu Tyr 
            20                  25                  30          


Lys Gln Glu Asn Asn Ile Leu Val Phe Asn Ala Glu Tyr Gly Asn Ser 
        35                  40                  45              


Ser Val Phe Leu Glu Asn Ser Thr Phe Asp Glu Phe Gly His Ser Ile 
    50                  55                  60                  


Asn Asp Tyr Ser Ile Ser Pro Asp Gly Gln Phe Ile Leu Leu Glu Tyr 
65                  70                  75                  80  


Asn Tyr Val Lys Gln Trp Arg His Ser Tyr Thr Ala Ser Tyr Asp Ile 
                85                  90                  95      


Tyr Asp Leu Asn Lys Arg Gln Leu Ile Thr Glu Glu Arg Ile Pro Asn 
            100                 105                 110         


Asn Thr Gln Trp Val Thr Trp Ser Pro Val Gly His Lys Leu Ala Tyr 
        115                 120                 125             


Val Trp Asn Asn Asp Ile Tyr Val Lys Ile Glu Pro Asn Leu Pro Ser 
    130                 135                 140                 


Tyr Arg Ile Thr Trp Thr Gly Lys Glu Asp Ile Ile Tyr Asn Gly Ile 
145                 150                 155                 160 


Thr Asp Trp Val Tyr Glu Glu Glu Val Phe Ser Ala Tyr Ser Ala Leu 
                165                 170                 175     


Trp Trp Ser Pro Asn Gly Thr Phe Leu Ala Tyr Ala Gln Phe Asn Asp 
            180                 185                 190         


Thr Glu Val Pro Leu Ile Glu Tyr Ser Phe Tyr Ser Asp Glu Ser Leu 
        195                 200                 205             


Gln Tyr Pro Lys Thr Val Arg Val Pro Tyr Pro Lys Ala Gly Ala Val 
    210                 215                 220                 


Asn Pro Thr Val Lys Phe Phe Val Val Asn Thr Asp Ser Leu Ser Ser 
225                 230                 235                 240 


Val Thr Asn Ala Thr Ser Ile Gln Ile Thr Ala Pro Ala Ser Met Leu 
                245                 250                 255     


Ile Gly Asp His Tyr Leu Cys Asp Val Thr Trp Ala Thr Gln Glu Arg 
            260                 265                 270         


Ile Ser Leu Gln Trp Leu Arg Arg Ile Gln Asn Tyr Ser Val Met Asp 
        275                 280                 285             


Ile Cys Asp Tyr Asp Glu Ser Ser Gly Arg Trp Asn Cys Leu Val Ala 
    290                 295                 300                 


Arg Gln His Ile Glu Met Ser Thr Thr Gly Trp Val Gly Arg Phe Arg 
305                 310                 315                 320 


Pro Ser Glu Pro His Phe Thr Leu Asp Gly Asn Ser Phe Tyr Lys Ile 
                325                 330                 335     


Ile Ser Asn Glu Glu Gly Tyr Arg His Ile Cys Tyr Phe Gln Ile Asp 
            340                 345                 350         


Lys Lys Asp Cys Thr Phe Ile Thr Lys Gly Thr Trp Glu Val Ile Gly 
        355                 360                 365             


Ile Glu Ala Leu Thr Ser Asp Tyr Leu Tyr Tyr Ile Ser Asn Glu Tyr 
    370                 375                 380                 


Lys Gly Met Pro Gly Gly Arg Asn Leu Tyr Lys Ile Gln Leu Ser Asp 
385                 390                 395                 400 


Tyr Thr Lys Val Thr Cys Leu Ser Cys Glu Leu Asn Pro Glu Arg Cys 
                405                 410                 415     


Gln Tyr Tyr Ser Val Ser Phe Ser Lys Glu Ala Lys Tyr Tyr Gln Leu 
            420                 425                 430         


Arg Cys Ser Gly Pro Gly Leu Pro Leu Tyr Thr Leu His Ser Ser Val 
        435                 440                 445             


Asn Asp Lys Gly Leu Arg Val Leu Glu Asp Asn Ser Ala Leu Asp Lys 
    450                 455                 460                 


Met Leu Gln Asn Val Gln Met Pro Ser Lys Lys Leu Asp Phe Ile Ile 
465                 470                 475                 480 


Leu Asn Glu Thr Lys Phe Trp Tyr Gln Met Ile Leu Pro Pro His Phe 
                485                 490                 495     


Asp Lys Ser Lys Lys Tyr Pro Leu Leu Leu Asp Val Tyr Ala Gly Pro 
            500                 505                 510         


Cys Ser Gln Lys Ala Asp Thr Val Phe Arg Leu Asn Trp Ala Thr Tyr 
        515                 520                 525             


Leu Ala Ser Thr Glu Asn Ile Ile Val Ala Ser Phe Asp Gly Arg Gly 
    530                 535                 540                 


Ser Gly Tyr Gln Gly Asp Lys Ile Met His Ala Ile Asn Arg Arg Leu 
545                 550                 555                 560 


Gly Thr Phe Glu Val Glu Asp Gln Ile Glu Ala Ala Arg Gln Phe Ser 
                565                 570                 575     


Lys Met Gly Phe Val Asp Asn Lys Arg Ile Ala Ile Trp Gly Trp Ser 
            580                 585                 590         


Tyr Gly Gly Tyr Val Thr Ser Met Val Leu Gly Ser Gly Ser Gly Val 
        595                 600                 605             


Phe Lys Cys Gly Ile Ala Val Ala Pro Val Ser Arg Trp Glu Tyr Tyr 
    610                 615                 620                 


Asp Ser Val Tyr Thr Glu Arg Tyr Met Gly Leu Pro Thr Pro Glu Asp 
625                 630                 635                 640 


Asn Leu Asp His Tyr Arg Asn Ser Thr Val Met Ser Arg Ala Glu Asn 
                645                 650                 655     


Phe Lys Gln Val Glu Tyr Leu Leu Ile His Gly Thr Ala Asp Asp Asn 
            660                 665                 670         


Val His Phe Gln Gln Ser Ala Gln Ile Ser Lys Ala Leu Val Asp Val 
        675                 680                 685             


Gly Val Asp Phe Gln Ala Met Trp Tyr Thr Asp Glu Asp His Gly Ile 
    690                 695                 700                 


Ala Ser Ser Thr Ala His Gln His Ile Tyr Thr His Met Ser His Phe 
705                 710                 715                 720 


Ile Lys Gln Cys Phe Ser Leu Pro 
                725             


<210>  3
<211>  3913
<212>  DNA
<213>  Homo sapiens

<220>
<221>  misc_feature
<222>  (1)..(766)
<223>  DPP4 membrane bound form (full sequence), cDNA

<400>  3
ctttcactgg caagagacgg agtcctgggt ttcagttcca gttgcctgcg gtgggctgtg       60

tgagtttgcc aaagtcccct gccctctctg ggtctcggtt ccctcgcctg tccacgtgag      120

gttggaggag ctgaacgccg acgtcatttt tagctaagag ggagcagggt ccccgagtcg      180

ccggcccagg gtctgcgcat ccgaggccgc gcgccctttc ccctccccca cggctcctcc      240

gggccccgca ctctgcgccc cggctgccgc ccagcgccct acaccgccct cagggggccc      300

tcgcgggctc cccccggccg ggatgccagt gccccgcgcc acgcgcgcct gctcccgcgc      360

cgcctgccct gcagcctgcc cgcggcgcct ttatacccag cgggctcggc gctcactaat      420

gtttaactcg gggccgaaac ttgccagcgg cgagtgactc caccgcccgg agcagcggtg      480

caggacgcgc gtctccgccg cccgcggtga cttctgcctg cgctccttct ctgaacgctc      540

acttccgagg agacgccgac gatgaagaca ccgtggaagg ttcttctggg actgctgggt      600

gctgctgcgc ttgtcaccat catcaccgtg cccgtggttc tgctgaacaa aggcacagat      660

gatgctacag ctgacagtcg caaaacttac actctaactg attacttaaa aaatacttat      720

agactgaagt tatactcctt aagatggatt tcagatcatg aatatctcta caaacaagaa      780

aataatatct tggtattcaa tgctgaatat ggaaacagct cagttttctt ggagaacagt      840

acatttgatg agtttggaca ttctatcaat gattattcaa tatctcctga tgggcagttt      900

attctcttag aatacaacta cgtgaagcaa tggaggcatt cctacacagc ttcatatgac      960

atttatgatt taaataaaag gcagctgatt acagaagaga ggattccaaa caacacacag     1020

tgggtcacat ggtcaccagt gggtcataaa ttggcatatg tttggaacaa tgacatttat     1080

gttaaaattg aaccaaattt accaagttac agaatcacat ggacggggaa agaagatata     1140

atatataatg gaataactga ctgggtttat gaagaggaag tcttcagtgc ctactctgct     1200

ctgtggtggt ctccaaacgg cactttttta gcatatgccc aatttaacga cacagaagtc     1260

ccacttattg aatactcctt ctactctgat gagtcactgc agtacccaaa gactgtacgg     1320

gttccatatc caaaggcagg agctgtgaat ccaactgtaa agttctttgt tgtaaataca     1380

gactctctca gctcagtcac caatgcaact tccatacaaa tcactgctcc tgcttctatg     1440

ttgatagggg atcactactt gtgtgatgtg acatgggcaa cacaagaaag aatttctttg     1500

cagtggctca ggaggattca gaactattcg gtcatggata tttgtgacta tgatgaatcc     1560

agtggaagat ggaactgctt agtggcacgg caacacattg aaatgagtac tactggctgg     1620

gttggaagat ttaggccttc agaacctcat tttacccttg atggtaatag cttctacaag     1680

atcatcagca atgaagaagg ttacagacac atttgctatt tccaaataga taaaaaagac     1740

tgcacattta ttacaaaagg cacctgggaa gtcatcggga tagaagctct aaccagtgat     1800

tatctatact acattagtaa tgaatataaa ggaatgccag gaggaaggaa tctttataaa     1860

atccaactta gtgactatac aaaagtgaca tgcctcagtt gtgagctgaa tccggaaagg     1920

tgtcagtact attctgtgtc attcagtaaa gaggcgaagt attatcagct gagatgttcc     1980

ggtcctggtc tgcccctcta tactctacac agcagcgtga atgataaagg gctgagagtc     2040

ctggaagaca attcagcttt ggataaaatg ctgcagaatg tccagatgcc ctccaaaaaa     2100

ctggacttca ttattttgaa tgaaacaaaa ttttggtatc agatgatctt gcctcctcat     2160

tttgataaat ccaagaaata tcctctacta ttagatgtgt atgcaggccc atgtagtcaa     2220

aaagcagaca ctgtcttcag actgaactgg gccacttacc ttgcaagcac agaaaacatt     2280

atagtagcta gctttgatgg cagaggaagt ggttaccaag gagataagat catgcatgca     2340

atcaacagaa gactgggaac atttgaagtt gaagatcaaa ttgaagcagc cagacaattt     2400

tcaaaaatgg gatttgtgga caacaaacga attgcaattt ggggctggtc atatggaggg     2460

tacgtaacct caatggtcct gggatcggga agtggcgtgt tcaagtgtgg aatagccgtg     2520

gcgcctgtat cccggtggga gtactatgac tcagtgtaca cagaacgtta catgggtctc     2580

ccaactccag aagacaacct tgaccattac agaaattcaa cagtcatgag cagagctgaa     2640

aattttaaac aagttgagta cctccttatt catggaacag cagatgataa cgttcacttt     2700

cagcagtcag ctcagatctc caaagccctg gtcgatgttg gagtggattt ccaggcaatg     2760

tggtatactg atgaagacca tggaatagct agcagcacag cacaccaaca tatatatacc     2820

cacatgagcc acttcataaa acaatgtttc tctttacctt agcacctcaa aataccatgc     2880

catttaaagc ttattaaaac tcatttttgt tttcattatc tcaaaactgc actgtcaaga     2940

tgatgatgat ctttaaaata cacactcaaa tcaagaaact taaggttacc tttgttccca     3000

aatttcatac ctatcatctt aagtagggac ttctgtcttc acaacagatt attaccttac     3060

agaagtttga attatccggt cgggttttat tgtttaaaat catttctgca tcagctgctg     3120

aaacaacaaa taggaattgt ttttatggag gctttgcata gattccctga gcaggatttt     3180

aatctttttc taactggact ggttcaaatg ttgttctctt ctttaaaggg atggcaagat     3240

gtgggcagtg atgtcactag ggcagggaca ggataagagg gattagggag agaagatagc     3300

agggcatggc tgggaaccca agtccaagca taccaacacg agcaggctac tgtcagctcc     3360

cctcggagaa gagctgttca cagccagact ggcacagttt tctgagaaag actattcaaa     3420

cagtctcagg aaatcaaata tgcaaagcac tgacttctaa gtaaaaccac agcagttgaa     3480

aagactccaa agaaatgtaa gggaaactgc cagcaacgca ggcccccagg tgccagttat     3540

ggctataggt gctacaaaaa cacagcaagg gtgatgggaa agcattgtaa atgtgctttt     3600

aaaaaaaaat actgatgttc ctagtgaaag aggcagcttg aaactgagat gtgaacacat     3660

cagcttgccc tgttaaaaga tgaaaatatt tgtatcacaa atcttaactt gaaggagtcc     3720

ttgcatcaat ttttcttatt tcatttcttt gagtgtctta attaaaagaa tattttaact     3780

tccttggact cattttaaaa aatggaacat aaaatacaat gttatgtatt attattccca     3840

ttctacatac tatggaattt ctcccagtca tttaataaat gtgccttcat tttttcagaa     3900

aaaaaaaaaa aaa                                                        3913


<210>  4
<211>  420
<212>  PRT
<213>  Homo sapiens

<220>
<221>  misc_feature
<222>  (1)..(420)
<223>  IL5R alpha subunit, Isoform 1

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  signal peptide 

<220>
<221>  misc_feature
<222>  (21)..(420)
<223>  mature IL5R alpha subunit, Isoform 1

<220>
<221>  misc_feature
<222>  (21)..(342)
<223>  extracellular domain 

<220>
<221>  misc_feature
<222>  (343)..(362)
<223>  transmembrane helix 

<220>
<221>  misc_feature
<222>  (363)..(420)
<223>  cytoplasmic domain 

<400>  4

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Asn Asp Glu His 
                325                 330                 335     


Lys Pro Leu Arg Glu Trp Phe Val Ile Val Ile Met Ala Thr Ile Cys 
            340                 345                 350         


Phe Ile Leu Leu Ile Leu Ser Leu Ile Cys Lys Ile Cys His Leu Trp 
        355                 360                 365             


Ile Lys Leu Phe Pro Pro Ile Pro Ala Pro Lys Ser Asn Ile Lys Asp 
    370                 375                 380                 


Leu Phe Val Thr Thr Asn Tyr Glu Lys Ala Gly Ser Ser Glu Thr Glu 
385                 390                 395                 400 


Ile Glu Val Ile Cys Tyr Ile Glu Lys Pro Gly Val Glu Thr Leu Glu 
                405                 410                 415     


Asp Ser Val Phe 
            420 


<210>  5
<211>  335
<212>  PRT
<213>  Homo sapiens

<220>
<221>  misc_feature
<222>  (1)..(335)
<223>  IL5R alpha subunit, Isoform 2

<400>  5

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Phe Ser Arg 
                325                 330                 335 


<210>  6
<211>  333
<212>  PRT
<213>  Homo sapiens

<220>
<221>  misc_feature
<222>  (1)..(333)
<223>  IL5R alpha subunit, Isoform 3

<400>  6

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Lys 
                325                 330             


<210>  7
<211>  378
<212>  PRT
<213>  Homo sapiens

<220>
<221>  misc_feature
<222>  (1)..(378)
<223>  IL5R alpha subunit, Isoform 4

<400>  7

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Asn Asp Glu His 
                325                 330                 335     


Lys Pro Leu Arg Glu Trp Phe Val Ile Val Ile Met Ala Thr Ile Cys 
            340                 345                 350         


Phe Ile Leu Leu Ile Leu Ser Leu Ile Cys Lys Ile Lys Leu Gly Pro 
        355                 360                 365             


Val Arg Arg Lys Leu Lys Ser Ser Val Ile 
    370                 375             


<210>  8
<211>  211
<212>  PRT
<213>  Homo sapiens

<220>
<221>  misc_feature
<222>  (1)..(420)
<223>  IL5R alpha subunit, Isoform 5

<400>  8

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Asn Asp Glu His Lys 
        115                 120                 125             


Pro Leu Arg Glu Trp Phe Val Ile Val Ile Met Ala Thr Ile Cys Phe 
    130                 135                 140                 


Ile Leu Leu Ile Leu Ser Leu Ile Cys Lys Ile Cys His Leu Trp Ile 
145                 150                 155                 160 


Lys Leu Phe Pro Pro Ile Pro Ala Pro Lys Ser Asn Ile Lys Asp Leu 
                165                 170                 175     


Phe Val Thr Thr Asn Tyr Glu Lys Ala Gly Ser Ser Glu Thr Glu Ile 
            180                 185                 190         


Glu Val Ile Cys Tyr Ile Glu Lys Pro Gly Val Glu Thr Leu Glu Asp 
        195                 200                 205             


Ser Val Phe 
    210     


<210>  9
<211>  134
<212>  PRT
<213>  Homo sapiens

<220>
<221>  misc_feature
<222>  (1)..(134)
<223>  Interleukin 5 (IL5)

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  signal peptide 

<220>
<221>  misc_feature
<222>  (20)..(115)
<223>  mature IL5

<400>  9

Met Arg Met Leu Leu His Leu Ser Leu Leu Ala Leu Gly Ala Ala Tyr 
1               5                   10                  15      


Val Tyr Ala Ile Pro Thr Glu Ile Pro Thr Ser Ala Leu Val Lys Glu 
            20                  25                  30          


Thr Leu Ala Leu Leu Ser Thr His Arg Thr Leu Leu Ile Ala Asn Glu 
        35                  40                  45              


Thr Leu Arg Ile Pro Val Pro Val His Lys Asn His Gln Leu Cys Thr 
    50                  55                  60                  


Glu Glu Ile Phe Gln Gly Ile Gly Thr Leu Glu Ser Gln Thr Val Gln 
65                  70                  75                  80  


Gly Gly Thr Val Glu Arg Leu Phe Lys Asn Leu Ser Leu Ile Lys Lys 
                85                  90                  95      


Tyr Ile Asp Gly Gln Lys Lys Lys Cys Gly Glu Glu Arg Arg Arg Val 
            100                 105                 110         


Asn Gln Phe Leu Asp Tyr Leu Gln Glu Phe Leu Gly Val Met Asn Thr 
        115                 120                 125             


Glu Trp Ile Ile Glu Ser 
    130                 


<210>  10
<211>  451
<212>  PRT
<213>  Homo sapiens

<220>
<221>  misc_feature
<222>  (1)..(451)
<223>  Benralizumab Heavy chain (HC)

<400>  10

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Ala Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Arg Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Ile Thr Ser Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Leu Cys 
                85                  90                  95      


Gly Arg Glu Gly Ile Arg Tyr Tyr Gly Leu Leu Gly Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  11
<211>  214
<212>  PRT
<213>  Homo sapiens

<220>
<221>  misc_feature
<222>  (1)..(214)
<223>  Benralizumab Light chain (LC)

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gly Thr Ser Glu Asp Ile Ile Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  12
<211>  121
<212>  PRT
<213>  Homo sapiens

<220>
<221>  misc_feature
<222>  (1)..(121)
<223>  Benralizumab VH

<400>  12

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Ala Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Arg Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Ile Thr Ser Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Leu Cys 
                85                  90                  95      


Gly Arg Glu Gly Ile Arg Tyr Tyr Gly Leu Leu Gly Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  13
<211>  107
<212>  PRT
<213>  Homo sapiens

<220>
<221>  misc_feature
<222>  (1)..(107)
<223>  Benralizumab VL

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gly Thr Ser Glu Asp Ile Ile Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  14
<211>  5
<212>  PRT
<213>  Homo sapiens

<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  Benralizumab VH-CDR1

<400>  14

Ser Tyr Val Ile His 
1               5                   


<210>  15
<211>  17
<212>  PRT
<213>  Homo sapiens

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  Benralizumab VH-CDR2

<400>  15

Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Arg Phe Lys 
1               5                   10                  15  

Gly  


<210>  16
<211>  12
<212>  PRT
<213>  Homo sapiens

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Benralizumab VH-CDR3

<400>  16

Glu Gly Ile Arg Tyr Tyr Gly Leu Leu Gly Asp Tyr 
1               5                   10                  


<210>  17
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  Benralizumab VL-CDR1

<400>  17

Gly Thr Ser Glu Asp Ile Ile Asn Tyr Leu Asn 
1               5                   10               


<210>  18
<211>  7
<212>  PRT
<213>  Homo sapiens

<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  Benralizumab VL-CDR2

<400>  18

His Thr Ser Arg Leu Gln Ser 
1               5      


<210>  19
<211>  9
<212>  PRT
<213>  Homo sapiens

<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  Benralizumab VL-CDR3

<400>  19

Gln Gln Gly Tyr Thr Leu Pro Tyr Thr 
1               5               


<210> 20
<211> 836
<212> PRT
<213> Homo sapiens

<220>
<221>  misc_feature
<222>  (1)..(836)
<223>  Periostin

<400> 20

Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Thr Thr Lys 
            660                 665                 670         


Ile Ile Thr Lys Val Val Glu Pro Lys Ile Lys Val Ile Glu Gly Ser 
        675                 680                 685             


Leu Gln Pro Ile Ile Lys Thr Glu Gly Pro Thr Leu Thr Lys Val Lys 
    690                 695                 700                 


Ile Glu Gly Glu Pro Glu Phe Arg Leu Ile Lys Glu Gly Glu Thr Ile 
705                 710                 715                 720 


Thr Glu Val Ile His Gly Glu Pro Ile Ile Lys Lys Tyr Thr Lys Ile 
                725                 730                 735     


Ile Asp Gly Val Pro Val Glu Ile Thr Glu Lys Glu Thr Arg Glu Glu 
            740                 745                 750         


Arg Ile Ile Thr Gly Pro Glu Ile Lys Tyr Thr Arg Ile Ser Thr Gly 
        755                 760                 765             


Gly Gly Glu Thr Glu Glu Thr Leu Lys Lys Leu Leu Gln Glu Glu Val 
    770                 775                 780                 


Thr Lys Val Thr Lys Phe Ile Glu Gly Gly Asp Gly His Leu Phe Glu 
785                 790                 795                 800 


Asp Glu Glu Ile Lys Arg Leu Leu Gln Gly Asp Thr Pro Val Arg Lys 
                805                 810                 815     


Leu Gln Ala Asn Lys Lys Val Gln Gly Ser Arg Arg Arg Leu Arg Glu 
            820                 825                 830         


Gly Arg Ser Gln 
        835     

