
                                SEQUENCE LISTING

<110> Juno Therapeutics, Inc.
      Thompson, Lucas James

<120> VECTORS AND GENETICALLY ENGINEERED
  IMMUNE CELLS EXPRESSING METABOLIC PATHWAY MODULATORS AND
  USES IN ADOPTIVE CELL THERAPY
  

<130> 735042003740

<140> Not Yet Assigned    
<141> Concurrently Herewith            

<150> 62/251,615          
<151> 2015-11-05  

<160> 97

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 414
<212> PRT
<213> Homo sapiens

<220> 
<223> C1ORF177 isoform 1(huLEM)

<300> 
<308> NCBI NP_689820.2
<309> 2007-11-16  

<400> 1
Met Arg Glu Ser Gln Asp Ala Ala Gly Ala His Gly Trp Asn Arg Val
 1               5                  10                  15      
Gly Ser Thr Ala Thr Lys Trp Phe Thr Gly Ala Pro Phe Gly Val Gln
            20                  25                  30          
Ser His Arg Phe Asp Ile Ser Ala Val Tyr Pro Asn Trp Lys Lys Phe
        35                  40                  45              
Ser Thr Phe Thr Glu Ala Pro Tyr Ser Thr Arg Tyr Ser Thr Gln Val
    50                  55                  60                  
Ser His Ile Gly Pro Gly Thr Tyr Ser Ser Lys Glu Thr Cys Phe Ser
65                  70                  75                  80  
Lys Lys Lys Leu Met Lys Glu Val Asp Thr Gly Trp Ala Lys Ala Gln
                85                  90                  95      
Glu Ala Thr Arg Leu Thr Gln Leu Pro His Phe Gln Tyr Gln Ala Ile
            100                 105                 110         
Met Lys Glu Lys Arg Leu Lys Glu Gln Lys Leu Gly Pro Gly Ser Tyr
        115                 120                 125             
Asn Leu Lys Asp Phe Leu Glu Gln Leu Arg Glu Lys Pro Cys Ser Thr
    130                 135                 140                 
Arg Gly Leu Leu Ser Ser Gly Glu Val Arg Phe Arg Gly Leu Thr Gly
145                 150                 155                 160 
Asn Tyr Tyr Pro Gly Pro Gly Asn Tyr Gly Glu Lys Gly Asn Pro Tyr
                165                 170                 175     
Thr Lys Leu Glu Glu Asn Ala Trp Asn Arg Ser His Ser Glu Gly Leu
            180                 185                 190         
Met Cys Arg Met Ser Asn Lys Pro His Pro Arg Pro His Gln Gly Ser
        195                 200                 205             
Gly Leu Gly Pro Gly Thr Tyr Phe Phe Lys Ser Asp Leu Glu Thr Tyr
    210                 215                 220                 
Val Ala Arg Ser Val Gly Thr Arg Gly Pro Tyr Asp Thr Phe Ser Gly
225                 230                 235                 240 
Asp Arg Ser Lys Pro Leu Pro Tyr Gly His Tyr Ser Met Gln Lys Lys
                245                 250                 255     
Lys Pro Arg Glu Leu Met Asn Phe Lys Ser Phe Val Glu Glu Leu Asn
            260                 265                 270         
Ser His His Asn Lys Lys His Gly Val Phe Ser Lys Leu Pro Arg Asn
        275                 280                 285             
Pro Lys Thr Pro Thr Glu Arg Ile Tyr Trp Ala Asn Leu Ser Gln Cys
    290                 295                 300                 
Pro Arg Thr Leu Ala Thr Ser Gly Pro Ser Phe Trp Leu Pro Gln Glu
305                 310                 315                 320 
Lys Lys Cys Lys Pro Val Asn Gln Pro Pro Phe Leu Leu Thr Ser Lys
                325                 330                 335     
Gly Ser Gly Ala Lys Ala Cys Gln Met Ile Met Gly Ser Trp Asn Pro
            340                 345                 350         
Val Gly Val Gly Arg Tyr Leu Asn Thr Trp Leu Met Glu Thr Lys Asp
        355                 360                 365             
Arg Arg Gln Arg Tyr Arg Ser Leu Phe Leu Ser Gly Ser Lys Arg Tyr
    370                 375                 380                 
Leu Ser Asp Leu Ala Arg Asp Met Leu Met Gln Ile Arg Leu Phe Cys
385                 390                 395                 400 
Trp Lys Gly Leu Glu Val Ile Asn Phe Gly Leu Ser Pro Met
                405                 410                 


<210> 2
<211> 418
<212> PRT
<213> Homo sapiens

<220> 
<223> C1ORF177 isoform2 (huLEM)

<300> 
<308> UniProt Q3ZCV2
<309> 2007-08-21  

<400> 2
Met Arg Glu Ser Gln Asp Ala Ala Gly Ala His Gly Trp Asn Arg Val
 1               5                  10                  15      
Gly Ser Thr Ala Thr Lys Trp Phe Thr Gly Ala Pro Phe Gly Val Gln
            20                  25                  30          
Ser His Arg Phe Asp Ile Ser Ala Val Tyr Pro Asn Trp Lys Lys Phe
        35                  40                  45              
Ser Thr Phe Thr Glu Ala Pro Tyr Ser Thr Arg Tyr Ser Thr Gln Val
    50                  55                  60                  
Ser His Ile Gly Pro Gly Thr Tyr Ser Ser Lys Glu Thr Cys Phe Ser
65                  70                  75                  80  
Lys Lys Lys Leu Met Lys Glu Val Asp Thr Gly Trp Ala Lys Ala Gln
                85                  90                  95      
Glu Ala Thr Arg Leu Thr Gln Leu Pro His Phe Gln Tyr Gln Ala Ile
            100                 105                 110         
Met Lys Glu Lys Arg Leu Lys Glu Gln Lys Leu Gly Pro Gly Ser Tyr
        115                 120                 125             
Asn Leu Lys Asp Phe Leu Glu Gln Leu Arg Glu Lys Pro Cys Ser Thr
    130                 135                 140                 
Arg Gly Leu Leu Ser Ser Gly Glu Val Arg Phe Arg Gly Leu Thr Gly
145                 150                 155                 160 
Asn Tyr Tyr Pro Gly Pro Gly Asn Tyr Gly Glu Lys Gly Asn Pro Tyr
                165                 170                 175     
Thr Lys Leu Glu Glu Asn Ala Trp Asn Arg Ser His Ser Glu Gly Leu
            180                 185                 190         
Met Cys Arg Met Ser Asn Lys Pro His Pro Arg Pro Tyr Gln Gly Ser
        195                 200                 205             
Gly Leu Gly Pro Gly Thr Tyr Phe Phe Lys Ser Asp Leu Glu Thr Tyr
    210                 215                 220                 
Val Ala Arg Ser Val Gly Thr Arg Gly Pro Tyr Asp Thr Phe Ser Gly
225                 230                 235                 240 
Asp Arg Ser Lys Pro Leu Pro Tyr Gly His Tyr Ser Met Gln Lys Lys
                245                 250                 255     
Lys Pro Arg Glu Leu Met Asn Phe Lys Ser Phe Val Glu Glu Leu Asn
            260                 265                 270         
Ser His His Asn Lys Lys His Gly Val Phe Ser Lys Leu Pro Arg Asn
        275                 280                 285             
Pro Lys Thr Pro Thr Glu Arg Ile Tyr Trp Ala Asn Leu Ser Gln Cys
    290                 295                 300                 
Pro Arg Thr Leu Ala Thr Ser Gly Pro Ser Phe Trp Leu Pro Gln Glu
305                 310                 315                 320 
Lys Lys Cys Lys Pro Val Asn Gln Pro Pro Phe Leu Leu Thr Ser Lys
                325                 330                 335     
Gly Ser Gly Ala Lys Ala Cys Gln Met Ile Met Gly Ser Trp Asn Pro
            340                 345                 350         
Val Gly Val Gly Arg Tyr Leu Asn Thr Trp Leu Met Glu Thr Lys Asp
        355                 360                 365             
Arg Arg Gln Arg Tyr Arg Ser Leu Phe Leu Ser Gly Ser Lys Arg Tyr
    370                 375                 380                 
Leu Ser Asp Leu Ala Arg Asp Met Leu Met Gln Glu Arg Ile Thr Pro
385                 390                 395                 400 
Phe Thr Lys Gly Lys Cys Pro Pro Thr Val Asp Tyr Asn Ser Asp Pro
                405                 410                 415     
Thr Pro
        


<210> 3
<211> 395
<212> PRT
<213> Homo sapiens

<220> 
<223> C1ORF177 isoform 1(huLEM)

<400> 3
Met Arg Glu Ser Gln Asp Ala Ala Gly Ala His Gly Trp Asn Arg Val
 1               5                  10                  15      
Gly Ser Thr Ala Thr Lys Trp Phe Thr Gly Ala Pro Phe Gly Val Gln
            20                  25                  30          
Ser His Arg Phe Asp Ile Ser Ala Val Tyr Pro Asn Trp Lys Lys Phe
        35                  40                  45              
Ser Thr Phe Thr Glu Ala Pro Tyr Ser Thr Arg Tyr Ser Thr Gln Val
    50                  55                  60                  
Ser His Ile Gly Pro Gly Thr Tyr Ser Ser Lys Glu Thr Cys Phe Ser
65                  70                  75                  80  
Lys Lys Lys Leu Met Lys Glu Val Asp Thr Gly Trp Ala Lys Ala Gln
                85                  90                  95      
Glu Ala Thr Arg Leu Thr Gln Leu Pro His Phe Gln Tyr Gln Ala Ile
            100                 105                 110         
Met Lys Glu Lys Arg Leu Lys Glu Gln Lys Leu Gly Pro Gly Ser Tyr
        115                 120                 125             
Asn Leu Lys Asp Phe Leu Glu Gln Leu Arg Glu Lys Pro Cys Ser Thr
    130                 135                 140                 
Arg Gly Leu Leu Ser Ser Gly Glu Val Arg Phe Arg Gly Leu Thr Gly
145                 150                 155                 160 
Asn Tyr Tyr Pro Gly Pro Gly Asn Tyr Gly Glu Lys Gly Asn Pro Tyr
                165                 170                 175     
Thr Lys Leu Glu Glu Asn Ala Trp Asn Arg Ser His Ser Glu Gly Leu
            180                 185                 190         
Met Cys Arg Met Ser Asn Lys Pro His Pro Arg Pro His Gln Gly Ser
        195                 200                 205             
Gly Leu Gly Pro Gly Thr Tyr Phe Phe Lys Ser Asp Leu Glu Thr Tyr
    210                 215                 220                 
Val Ala Arg Ser Val Gly Thr Arg Gly Pro Tyr Asp Thr Phe Ser Gly
225                 230                 235                 240 
Asp Arg Ser Lys Pro Leu Pro Tyr Gly His Tyr Ser Met Gln Lys Lys
                245                 250                 255     
Lys Pro Arg Glu Leu Met Asn Phe Lys Ser Phe Val Glu Glu Leu Asn
            260                 265                 270         
Ser His His Asn Lys Lys His Gly Val Phe Ser Lys Leu Pro Arg Asn
        275                 280                 285             
Pro Lys Thr Pro Thr Glu Arg Ile Tyr Trp Ala Asn Leu Ser Gln Cys
    290                 295                 300                 
Pro Arg Thr Leu Ala Thr Ser Gly Pro Ser Phe Trp Leu Pro Gln Glu
305                 310                 315                 320 
Lys Lys Cys Lys Pro Val Asn Gln Pro Pro Phe Leu Leu Thr Ser Lys
                325                 330                 335     
Gly Ser Gly Ala Lys Ala Cys Gln Met Ile Met Gly Ser Trp Asn Pro
            340                 345                 350         
Val Gly Val Gly Arg Tyr Leu Asn Thr Trp Leu Met Glu Thr Lys Asp
        355                 360                 365             
Arg Arg Gln Arg Tyr Arg Ser Leu Phe Leu Ser Gly Ser Lys Arg Tyr
    370                 375                 380                 
Leu Ser Asp Leu Ala Arg Asp Met Leu Met Gln
385                 390                 395 


<210> 4
<211> 559
<212> PRT
<213> Homo sapiens

<220> 
<223> Glycerol kinase (Gyk)

<300> 
<308> UniProt Q14410
<309> 2001-01-11   

<400> 4
Met Ala Ala Ser Lys Lys Ala Val Leu Gly Pro Leu Val Gly Ala Val
 1               5                  10                  15      
Asp Gln Gly Thr Ser Ser Thr Arg Phe Leu Val Phe Asn Ser Lys Thr
            20                  25                  30          
Ala Glu Leu Leu Ser His His Gln Val Glu Ile Lys Gln Glu Phe Pro
        35                  40                  45              
Arg Glu Gly Trp Val Glu Gln Asp Pro Lys Glu Ile Leu His Ser Val
    50                  55                  60                  
Tyr Glu Cys Ile Glu Lys Thr Cys Glu Lys Leu Gly Gln Leu Asn Ile
65                  70                  75                  80  
Asp Ile Ser Asn Ile Lys Ala Ile Gly Val Ser Asn Gln Arg Glu Thr
                85                  90                  95      
Thr Val Val Trp Asp Lys Ile Thr Gly Glu Pro Leu Tyr Asn Ala Val
            100                 105                 110         
Val Trp Leu Asp Leu Arg Thr Gln Ser Thr Val Glu Ser Leu Ser Lys
        115                 120                 125             
Arg Ile Pro Gly Asn Asn Asn Phe Val Lys Ser Lys Thr Gly Leu Pro
    130                 135                 140                 
Leu Ser Thr Tyr Phe Ser Ala Val Lys Leu Arg Trp Leu Leu Asp Asn
145                 150                 155                 160 
Val Arg Lys Val Gln Lys Ala Val Glu Glu Lys Arg Ala Leu Phe Gly
                165                 170                 175     
Thr Ile Asp Ser Trp Leu Ile Trp Ser Leu Thr Gly Gly Val Asn Gly
            180                 185                 190         
Gly Val His Cys Thr Asp Val Thr Asn Ala Ser Arg Thr Met Leu Phe
        195                 200                 205             
Asn Ile His Ser Leu Glu Trp Asp Lys Gln Leu Cys Glu Phe Phe Gly
    210                 215                 220                 
Ile Pro Met Glu Ile Leu Pro Asn Val Arg Ser Ser Ser Glu Ile Tyr
225                 230                 235                 240 
Gly Leu Met Lys Ile Ser His Ser Val Lys Ala Gly Ala Leu Glu Gly
                245                 250                 255     
Val Pro Ile Ser Gly Cys Leu Gly Asp Gln Ser Ala Ala Leu Val Gly
            260                 265                 270         
Gln Met Cys Phe Gln Ile Gly Gln Ala Lys Asn Thr Tyr Gly Thr Gly
        275                 280                 285             
Cys Phe Leu Leu Cys Asn Thr Gly His Lys Cys Val Phe Ser Asp His
    290                 295                 300                 
Gly Leu Leu Thr Thr Val Ala Tyr Lys Leu Gly Arg Asp Lys Pro Val
305                 310                 315                 320 
Tyr Tyr Ala Leu Glu Gly Ser Val Ala Ile Ala Gly Ala Val Ile Arg
                325                 330                 335     
Trp Leu Arg Asp Asn Leu Gly Ile Ile Lys Thr Ser Glu Glu Ile Glu
            340                 345                 350         
Lys Leu Ala Lys Glu Val Gly Thr Ser Tyr Gly Cys Tyr Phe Val Pro
        355                 360                 365             
Ala Phe Ser Gly Leu Tyr Ala Pro Tyr Trp Glu Pro Ser Ala Arg Gly
    370                 375                 380                 
Ile Ile Cys Gly Leu Thr Gln Phe Thr Asn Lys Cys His Ile Ala Phe
385                 390                 395                 400 
Ala Ala Leu Glu Ala Val Cys Phe Gln Thr Arg Glu Ile Leu Asp Ala
                405                 410                 415     
Met Asn Arg Asp Cys Gly Ile Pro Leu Ser His Leu Gln Val Asp Gly
            420                 425                 430         
Gly Met Thr Ser Asn Lys Ile Leu Met Gln Leu Gln Ala Asp Ile Leu
        435                 440                 445             
Tyr Ile Pro Val Val Lys Pro Ser Met Pro Glu Thr Thr Ala Leu Gly
    450                 455                 460                 
Ala Ala Met Ala Ala Gly Ala Ala Glu Gly Val Gly Val Trp Ser Leu
465                 470                 475                 480 
Glu Pro Glu Asp Leu Ser Ala Val Thr Met Glu Arg Phe Glu Pro Gln
                485                 490                 495     
Ile Asn Ala Glu Glu Ser Glu Ile Arg Tyr Ser Thr Trp Lys Lys Ala
            500                 505                 510         
Val Met Lys Ser Met Gly Trp Val Thr Thr Gln Ser Pro Glu Ser Gly
        515                 520                 525             
Asp Pro Ser Ile Phe Cys Ser Leu Pro Leu Gly Phe Phe Ile Val Ser
    530                 535                 540                 
Ser Met Val Met Leu Ile Gly Ala Arg Tyr Ile Ser Gly Ile Pro
545                 550                 555                 


<210> 5
<211> 553
<212> PRT
<213> Homo sapiens

<220> 
<223> Glycerol kinase (Gyk)

<300> 
<308> GenBank CAA55365.1
<309> 2008-10-07  

<400> 5
Met Ala Ala Pro Lys Thr Ala Ala Val Gly Pro Leu Val Gly Ala Val
 1               5                  10                  15      
Val Gln Gly Thr Asn Ser Thr Arg Phe Leu Val Phe Asn Ser Lys Thr
            20                  25                  30          
Ala Glu Leu Leu Ser His His Lys Val Glu Leu Thr Gln Glu Phe Pro
        35                  40                  45              
Lys Glu Gly Trp Val Glu Gln Asp Pro Lys Glu Ile Leu Gln Ser Val
    50                  55                  60                  
Tyr Glu Cys Ile Ala Arg Thr Cys Glu Lys Leu Asp Glu Leu Asn Ile
65                  70                  75                  80  
Asp Ile Ser Asn Ile Lys Ala Val Gly Val Ser Asn Gln Arg Glu Thr
                85                  90                  95      
Thr Val Ile Trp Asp Lys Leu Thr Gly Glu Pro Leu Tyr Asn Ala Val
            100                 105                 110         
Val Trp Leu Asp Leu Arg Thr Gln Thr Thr Val Glu Asp Leu Ser Lys
        115                 120                 125             
Lys Ile Pro Gly Asn Ser Asn Phe Val Lys Ser Lys Thr Gly Leu Pro
    130                 135                 140                 
Leu Ser Thr Tyr Phe Ser Ala Val Lys Leu Arg Trp Met Leu Asp Asn
145                 150                 155                 160 
Val Arg Asn Val Gln Lys Ala Val Glu Glu Gly Arg Ala Leu Phe Gly
                165                 170                 175     
Thr Ile Asp Ser Trp Leu Ile Trp Ser Leu Thr Gly Gly Val Asn Gly
            180                 185                 190         
Gly Val His Cys Thr Asp Val Thr Asn Ala Ser Arg Thr Met Leu Phe
        195                 200                 205             
Asn Ile His Ser Leu Glu Trp Asp Lys Glu Leu Cys Asp Phe Phe Glu
    210                 215                 220                 
Ile Pro Met Asp Leu Leu Pro Asn Val Phe Ser Ser Ser Glu Ile Tyr
225                 230                 235                 240 
Gly Leu Ile Lys Thr Gly Ala Leu Glu Gly Val Pro Ile Ser Gly Cys
                245                 250                 255     
Leu Gly Asp Gln Cys Ala Ala Leu Val Gly Gln Met Cys Phe Gln Glu
            260                 265                 270         
Gly Gln Ala Lys Asn Thr Tyr Gly Thr Gly Cys Phe Leu Leu Cys Asn
        275                 280                 285             
Thr Gly Arg Lys Cys Val Phe Ser Glu His Gly Leu Leu Thr Thr Val
    290                 295                 300                 
Ala Tyr Lys Leu Gly Arg Glu Lys Pro Ala Tyr Tyr Ala Leu Glu Gly
305                 310                 315                 320 
Ser Val Ala Ile Ala Gly Ala Val Ile Arg Trp Leu Arg Asp Asn Leu
                325                 330                 335     
Gly Ile Ile Glu Thr Ser Gly Asp Ile Glu Arg Leu Ala Lys Glu Val
            340                 345                 350         
Gly Thr Ser Tyr Gly Cys Tyr Phe Val Pro Ala Phe Ser Gly Leu Tyr
        355                 360                 365             
Ala Pro Tyr Trp Glu Pro Ser Ala Arg Gly Ile Leu Cys Gly Leu Thr
    370                 375                 380                 
Gln Phe Thr Asn Lys Cys His Ile Ala Phe Ala Ala Leu Glu Ala Val
385                 390                 395                 400 
Cys Phe Gln Thr Arg Glu Ile Leu Glu Ala Met Asn Arg Asp Cys Gly
                405                 410                 415     
Ile Pro Leu Arg His Leu Gln Val Asp Gly Gly Met Thr Asn Asn Lys
            420                 425                 430         
Val Leu Met Gln Leu Gln Ala Asp Ile Leu His Ile Pro Val Ile Lys
        435                 440                 445             
Pro Phe Met Pro Glu Thr Thr Ala Leu Gly Ala Ala Met Ala Ala Gly
    450                 455                 460                 
Ala Ala Glu Gly Val Ser Val Trp Ser Leu Glu Pro Gln Ala Leu Ser
465                 470                 475                 480 
Val Leu Arg Met Glu Arg Phe Glu Pro Gln Ile Gln Ala Thr Glu Ser
                485                 490                 495     
Glu Ile Arg Tyr Ala Thr Trp Lys Lys Ala Val Met Lys Ser Met Gly
            500                 505                 510         
Trp Val Thr Ser Gln Ser Pro Glu Gly Gly Asp Pro Ser Ile Phe Cys
        515                 520                 525             
Ser Leu Pro Leu Gly Phe Phe Ile Val Ser Ser Met Val Met Leu Ile
    530                 535                 540                 
Gly Ala Arg Tyr Ile Ser Gly Val Pro
545                 550             


<210> 6
<211> 553
<212> PRT
<213> Homo sapiens

<220> 
<223> Glycerol kinase (Gyk)

<300> 
<308> GenBank CAA55364.1
<309> 2005-04-18  

<400> 6
Met Ala Ala Ser Lys Lys Ala Val Leu Gly Pro Leu Val Gly Ala Val
 1               5                  10                  15      
Asp Gln Gly Thr Ser Ser Thr Arg Phe Leu Val Phe Asn Ser Arg Thr
            20                  25                  30          
Ala Glu Leu Leu Ser His His Gln Val Glu Ile Lys Gln Glu Phe Pro
        35                  40                  45              
Arg Glu Gly Trp Val Glu Gln Asp Pro Lys Glu Ile Leu His Ser Val
    50                  55                  60                  
Tyr Glu Cys Ile Glu Lys Thr Cys Glu Lys Leu Gly Gln Leu Asn Ile
65                  70                  75                  80  
Gly Ile Ser Asn Ile Lys Ala Ile Gly Val Ser Asn Gln Arg Glu Thr
                85                  90                  95      
Thr Val Ala Trp Asp Lys Ile Thr Gly Glu Pro Leu Tyr Asn Ala Val
            100                 105                 110         
Val Trp Leu Asp Leu Arg Thr Gln Ser Thr Val Glu Ser Leu Ser Lys
        115                 120                 125             
Arg Ile Pro Gly Asn Asn Asn Phe Val Lys Ser Lys Thr Gly Leu Pro
    130                 135                 140                 
Leu Ser Thr Tyr Phe Ser Ala Val Lys Leu Arg Trp Leu Leu Asp Asn
145                 150                 155                 160 
Val Arg Lys Val Gln Lys Ala Val Glu Glu Lys Arg Ala Leu Phe Gly
                165                 170                 175     
Thr Ile Asp Ser Trp Leu Ile Trp Ser Leu Thr Gly Gly Val Asn Gly
            180                 185                 190         
Gly Val His Cys Thr Asp Val Thr Asn Ala Ser Arg Thr Met Leu Phe
        195                 200                 205             
Asn Ile His Ser Leu Glu Trp Asp Lys Gln Leu Cys Glu Phe Phe Gly
    210                 215                 220                 
Ile Pro Met Glu Ile Leu Pro His Val Arg Ser Ser Ser Glu Ile Tyr
225                 230                 235                 240 
Gly Leu Met Lys Ala Gly Ala Leu Glu Gly Val Pro Ile Ser Gly Cys
                245                 250                 255     
Leu Gly Asp Gln Ser Ala Ala Leu Val Gly Gln Met Cys Phe Gln Ile
            260                 265                 270         
Gly Gln Ala Lys Asn Thr Tyr Gly Thr Gly Cys Phe Leu Leu Cys Asn
        275                 280                 285             
Thr Gly His Lys Cys Val Phe Ser Asp His Gly Leu Leu Thr Thr Val
    290                 295                 300                 
Ala Tyr Lys Leu Gly Arg Asp Lys Pro Val Tyr Tyr Ala Leu Glu Gly
305                 310                 315                 320 
Ser Val Ala Ile Ala Gly Ala Val Ile Arg Trp Leu Arg Asp Asn Leu
                325                 330                 335     
Gly Ile Ile Lys Thr Ser Glu Glu Ile Glu Lys Leu Ala Lys Glu Val
            340                 345                 350         
Gly Thr Ser Tyr Gly Cys Tyr Phe Val Pro Ala Phe Ser Gly Leu Tyr
        355                 360                 365             
Ala Pro Tyr Trp Glu Pro Ser Ala Arg Gly Ile Ile Cys Gly Leu Thr
    370                 375                 380                 
Gln Phe Thr Asn Lys Cys His Ile Ala Phe Ala Ala Leu Glu Ala Val
385                 390                 395                 400 
Cys Phe Gln Thr Arg Glu Ile Leu Asp Ala Met Asn Arg Asp Cys Gly
                405                 410                 415     
Ile Pro Leu Ser His Leu Gln Val Asp Gly Gly Met Thr Ser Asn Lys
            420                 425                 430         
Ile Leu Met Gln Leu Gln Ala Asp Ile Leu Tyr Ile Pro Val Val Lys
        435                 440                 445             
Pro Leu Met Pro Glu Thr Thr Ala Leu Gly Ala Ala Met Ala Ala Gly
    450                 455                 460                 
Ala Ala Glu Gly Val Asp Val Trp Ser Leu Glu Pro Glu Asp Leu Ser
465                 470                 475                 480 
Ala Val Thr Met Glu Arg Phe Glu Pro Gln Ile Asn Ala Glu Glu Ser
                485                 490                 495     
Glu Ile Arg Tyr Ser Thr Trp Lys Lys Ala Val Met Lys Ser Met Gly
            500                 505                 510         
Trp Val Thr Thr Gln Ser Pro Glu Gly Gly Asp Pro Ser Val Phe Cys
        515                 520                 525             
Ser Leu Pro Leu Gly Phe Phe Ile Val Ser Ser Met Ala Met Leu Ile
    530                 535                 540                 
Gly Ala Arg Tyr Ile Ser Gly Ile Pro
545                 550             


<210> 7
<211> 488
<212> PRT
<213> Homo sapiens

<220> 
<223> DAG O-acetyltransferase 1 (DGAT1)

<300> 
<308> UniProt O75907
<309> 2001-10-18  

<400> 7
Met Gly Asp Arg Gly Ser Ser Arg Arg Arg Arg Thr Gly Ser Arg Pro
 1               5                  10                  15      
Ser Ser His Gly Gly Gly Gly Pro Ala Ala Ala Glu Glu Glu Val Arg
            20                  25                  30          
Asp Ala Ala Ala Gly Pro Asp Val Gly Ala Ala Gly Asp Ala Pro Ala
        35                  40                  45              
Pro Ala Pro Asn Lys Asp Gly Asp Ala Gly Val Gly Ser Gly His Trp
    50                  55                  60                  
Glu Leu Arg Cys His Arg Leu Gln Asp Ser Leu Phe Ser Ser Asp Ser
65                  70                  75                  80  
Gly Phe Ser Asn Tyr Arg Gly Ile Leu Asn Trp Cys Val Val Met Leu
                85                  90                  95      
Ile Leu Ser Asn Ala Arg Leu Phe Leu Glu Asn Leu Ile Lys Tyr Gly
            100                 105                 110         
Ile Leu Val Asp Pro Ile Gln Val Val Ser Leu Phe Leu Lys Asp Pro
        115                 120                 125             
Tyr Ser Trp Pro Ala Pro Cys Leu Val Ile Ala Ala Asn Val Phe Ala
    130                 135                 140                 
Val Ala Ala Phe Gln Val Glu Lys Arg Leu Ala Val Gly Ala Leu Thr
145                 150                 155                 160 
Glu Gln Ala Gly Leu Leu Leu His Val Ala Asn Leu Ala Thr Ile Leu
                165                 170                 175     
Cys Phe Pro Ala Ala Val Val Leu Leu Val Glu Ser Ile Thr Pro Val
            180                 185                 190         
Gly Ser Leu Leu Ala Leu Met Ala His Thr Ile Leu Phe Leu Lys Leu
        195                 200                 205             
Phe Ser Tyr Arg Asp Val Asn Ser Trp Cys Arg Arg Ala Arg Ala Lys
    210                 215                 220                 
Ala Ala Ser Ala Gly Lys Lys Ala Ser Ser Ala Ala Ala Pro His Thr
225                 230                 235                 240 
Val Ser Tyr Pro Asp Asn Leu Thr Tyr Arg Asp Leu Tyr Tyr Phe Leu
                245                 250                 255     
Phe Ala Pro Thr Leu Cys Tyr Glu Leu Asn Phe Pro Arg Ser Pro Arg
            260                 265                 270         
Ile Arg Lys Arg Phe Leu Leu Arg Arg Ile Leu Glu Met Leu Phe Phe
        275                 280                 285             
Thr Gln Leu Gln Val Gly Leu Ile Gln Gln Trp Met Val Pro Thr Ile
    290                 295                 300                 
Gln Asn Ser Met Lys Pro Phe Lys Asp Met Asp Tyr Ser Arg Ile Ile
305                 310                 315                 320 
Glu Arg Leu Leu Lys Leu Ala Val Pro Asn His Leu Ile Trp Leu Ile
                325                 330                 335     
Phe Phe Tyr Trp Leu Phe His Ser Cys Leu Asn Ala Val Ala Glu Leu
            340                 345                 350         
Met Gln Phe Gly Asp Arg Glu Phe Tyr Arg Asp Trp Trp Asn Ser Glu
        355                 360                 365             
Ser Val Thr Tyr Phe Trp Gln Asn Trp Asn Ile Pro Val His Lys Trp
    370                 375                 380                 
Cys Ile Arg His Phe Tyr Lys Pro Met Leu Arg Arg Gly Ser Ser Lys
385                 390                 395                 400 
Trp Met Ala Arg Thr Gly Val Phe Leu Ala Ser Ala Phe Phe His Glu
                405                 410                 415     
Tyr Leu Val Ser Val Pro Leu Arg Met Phe Arg Leu Trp Ala Phe Thr
            420                 425                 430         
Gly Met Met Ala Gln Ile Pro Leu Ala Trp Phe Val Gly Arg Phe Phe
        435                 440                 445             
Gln Gly Asn Tyr Gly Asn Ala Ala Val Trp Leu Ser Leu Ile Ile Gly
    450                 455                 460                 
Gln Pro Ile Ala Val Leu Met Tyr Val His Asp Tyr Tyr Val Leu Asn
465                 470                 475                 480 
Tyr Glu Ala Pro Ala Ala Glu Ala
                485             


<210> 8
<211> 828
<212> PRT
<213> Homo sapiens

<220> 
<223> Glycerol-3-phosphate acetyltransferase
      mitochondrial (GPAM)

<300> 
<308> UniProt Q9HCL2
<309> 2001-06-01  

<400> 8
Met Asp Glu Ser Ala Leu Thr Leu Gly Thr Ile Asp Val Ser Tyr Leu
 1               5                  10                  15      
Pro His Ser Ser Glu Tyr Ser Val Gly Arg Cys Lys His Thr Ser Glu
            20                  25                  30          
Glu Trp Gly Glu Cys Gly Phe Arg Pro Thr Ile Phe Arg Ser Ala Thr
        35                  40                  45              
Leu Lys Trp Lys Glu Ser Leu Met Ser Arg Lys Arg Pro Phe Val Gly
    50                  55                  60                  
Arg Cys Cys Tyr Ser Cys Thr Pro Gln Ser Trp Asp Lys Phe Phe Asn
65                  70                  75                  80  
Pro Ser Ile Pro Ser Leu Gly Leu Arg Asn Val Ile Tyr Ile Asn Glu
                85                  90                  95      
Thr His Thr Arg His Arg Gly Trp Leu Ala Arg Arg Leu Ser Tyr Val
            100                 105                 110         
Leu Phe Ile Gln Glu Arg Asp Val His Lys Gly Met Phe Ala Thr Asn
        115                 120                 125             
Val Thr Glu Asn Val Leu Asn Ser Ser Arg Val Gln Glu Ala Ile Ala
    130                 135                 140                 
Glu Val Ala Ala Glu Leu Asn Pro Asp Gly Ser Ala Gln Gln Gln Ser
145                 150                 155                 160 
Lys Ala Val Asn Lys Val Lys Lys Lys Ala Lys Arg Ile Leu Gln Glu
                165                 170                 175     
Met Val Ala Thr Val Ser Pro Ala Met Ile Arg Leu Thr Gly Trp Val
            180                 185                 190         
Leu Leu Lys Leu Phe Asn Ser Phe Phe Trp Asn Ile Gln Ile His Lys
        195                 200                 205             
Gly Gln Leu Glu Met Val Lys Ala Ala Thr Glu Thr Asn Leu Pro Leu
    210                 215                 220                 
Leu Phe Leu Pro Val His Arg Ser His Ile Asp Tyr Leu Leu Leu Thr
225                 230                 235                 240 
Phe Ile Leu Phe Cys His Asn Ile Lys Ala Pro Tyr Ile Ala Ser Gly
                245                 250                 255     
Asn Asn Leu Asn Ile Pro Ile Phe Ser Thr Leu Ile His Lys Leu Gly
            260                 265                 270         
Gly Phe Phe Ile Arg Arg Arg Leu Asp Glu Thr Pro Asp Gly Arg Lys
        275                 280                 285             
Asp Val Leu Tyr Arg Ala Leu Leu His Gly His Ile Val Glu Leu Leu
    290                 295                 300                 
Arg Gln Gln Gln Phe Leu Glu Ile Phe Leu Glu Gly Thr Arg Ser Arg
305                 310                 315                 320 
Ser Gly Lys Thr Ser Cys Ala Arg Ala Gly Leu Leu Ser Val Val Val
                325                 330                 335     
Asp Thr Leu Ser Thr Asn Val Ile Pro Asp Ile Leu Ile Ile Pro Val
            340                 345                 350         
Gly Ile Ser Tyr Asp Arg Ile Ile Glu Gly His Tyr Asn Gly Glu Gln
        355                 360                 365             
Leu Gly Lys Pro Lys Lys Asn Glu Ser Leu Trp Ser Val Ala Arg Gly
    370                 375                 380                 
Val Ile Arg Met Leu Arg Lys Asn Tyr Gly Cys Val Arg Val Asp Phe
385                 390                 395                 400 
Ala Gln Pro Phe Ser Leu Lys Glu Tyr Leu Glu Ser Gln Ser Gln Lys
                405                 410                 415     
Pro Val Ser Ala Leu Leu Ser Leu Glu Gln Ala Leu Leu Pro Ala Ile
            420                 425                 430         
Leu Pro Ser Arg Pro Ser Asp Ala Ala Asp Glu Gly Arg Asp Thr Ser
        435                 440                 445             
Ile Asn Glu Ser Arg Asn Ala Thr Asp Glu Ser Leu Arg Arg Arg Leu
    450                 455                 460                 
Ile Ala Asn Leu Ala Glu His Ile Leu Phe Thr Ala Ser Lys Ser Cys
465                 470                 475                 480 
Ala Ile Met Ser Thr His Ile Val Ala Cys Leu Leu Leu Tyr Arg His
                485                 490                 495     
Arg Gln Gly Ile Asp Leu Ser Thr Leu Val Glu Asp Phe Phe Val Met
            500                 505                 510         
Lys Glu Glu Val Leu Ala Arg Asp Phe Asp Leu Gly Phe Ser Gly Asn
        515                 520                 525             
Ser Glu Asp Val Val Met His Ala Ile Gln Leu Leu Gly Asn Cys Val
    530                 535                 540                 
Thr Ile Thr His Thr Ser Arg Asn Asp Glu Phe Phe Ile Thr Pro Ser
545                 550                 555                 560 
Thr Thr Val Pro Ser Val Phe Glu Leu Asn Phe Tyr Ser Asn Gly Val
                565                 570                 575     
Leu His Val Phe Ile Met Glu Ala Ile Ile Ala Cys Ser Leu Tyr Ala
            580                 585                 590         
Val Leu Asn Lys Arg Gly Leu Gly Gly Pro Thr Ser Thr Pro Pro Asn
        595                 600                 605             
Leu Ile Ser Gln Glu Gln Leu Val Arg Lys Ala Ala Ser Leu Cys Tyr
    610                 615                 620                 
Leu Leu Ser Asn Glu Gly Thr Ile Ser Leu Pro Cys Gln Thr Phe Tyr
625                 630                 635                 640 
Gln Val Cys His Glu Thr Val Gly Lys Phe Ile Gln Tyr Gly Ile Leu
                645                 650                 655     
Thr Val Ala Glu His Asp Asp Gln Glu Asp Ile Ser Pro Ser Leu Ala
            660                 665                 670         
Glu Gln Gln Trp Asp Lys Lys Leu Pro Glu Pro Leu Ser Trp Arg Ser
        675                 680                 685             
Asp Glu Glu Asp Glu Asp Ser Asp Phe Gly Glu Glu Gln Arg Asp Cys
    690                 695                 700                 
Tyr Leu Lys Val Ser Gln Ser Lys Glu His Gln Gln Phe Ile Thr Phe
705                 710                 715                 720 
Leu Gln Arg Leu Leu Gly Pro Leu Leu Glu Ala Tyr Ser Ser Ala Ala
                725                 730                 735     
Ile Phe Val His Asn Phe Ser Gly Pro Val Pro Glu Pro Glu Tyr Leu
            740                 745                 750         
Gln Lys Leu His Lys Tyr Leu Ile Thr Arg Thr Glu Arg Asn Val Ala
        755                 760                 765             
Val Tyr Ala Glu Ser Ala Thr Tyr Cys Leu Val Lys Asn Ala Val Lys
    770                 775                 780                 
Met Phe Lys Asp Ile Gly Val Phe Lys Glu Thr Lys Gln Lys Arg Val
785                 790                 795                 800 
Ser Val Leu Glu Leu Ser Ser Thr Phe Leu Pro Gln Cys Asn Arg Gln
                805                 810                 815     
Lys Leu Leu Glu Tyr Ile Leu Ser Phe Val Val Leu
            820                 825             


<210> 9
<211> 335
<212> PRT
<213> Homo sapiens

<220> 
<223> Monoacylglycerol O-acetyltransferase (MOGAT1)

<300> 
<308> UniProt Q96PD6
<309> 2006-09-05  

<400> 9
Met Lys Val Glu Phe Ala Pro Leu Asn Ile Gln Leu Ala Arg Arg Leu
 1               5                  10                  15      
Gln Thr Val Ala Val Leu Gln Trp Val Leu Lys Tyr Leu Leu Leu Gly
            20                  25                  30          
Pro Met Ser Ile Gly Ile Thr Val Met Leu Ile Ile His Asn Tyr Leu
        35                  40                  45              
Phe Leu Tyr Ile Pro Tyr Leu Met Trp Leu Tyr Phe Asp Trp His Thr
    50                  55                  60                  
Pro Glu Arg Gly Gly Arg Arg Ser Ser Trp Ile Lys Asn Trp Thr Leu
65                  70                  75                  80  
Trp Lys His Phe Lys Asp Tyr Phe Pro Ile His Leu Ile Lys Thr Gln
                85                  90                  95      
Asp Leu Asp Pro Ser His Asn Tyr Ile Phe Gly Phe His Pro His Gly
            100                 105                 110         
Ile Met Ala Val Gly Ala Phe Gly Asn Phe Ser Val Asn Tyr Ser Asp
        115                 120                 125             
Phe Lys Asp Leu Phe Pro Gly Phe Thr Ser Tyr Leu His Val Leu Pro
    130                 135                 140                 
Leu Trp Phe Trp Cys Pro Val Phe Arg Glu Tyr Val Met Ser Val Gly
145                 150                 155                 160 
Leu Val Ser Val Ser Lys Lys Ser Val Ser Tyr Met Val Ser Lys Glu
                165                 170                 175     
Gly Gly Gly Asn Ile Ser Val Ile Val Leu Gly Gly Ala Lys Glu Ser
            180                 185                 190         
Leu Asp Ala His Pro Gly Lys Phe Thr Leu Phe Ile Arg Gln Arg Lys
        195                 200                 205             
Gly Phe Val Lys Ile Ala Leu Thr His Gly Ala Ser Leu Val Pro Val
    210                 215                 220                 
Val Ser Phe Gly Glu Asn Glu Leu Phe Lys Gln Thr Asp Asn Pro Glu
225                 230                 235                 240 
Gly Ser Trp Ile Arg Thr Val Gln Asn Lys Leu Gln Lys Ile Met Gly
                245                 250                 255     
Phe Ala Leu Pro Leu Phe His Ala Arg Gly Val Phe Gln Tyr Asn Phe
            260                 265                 270         
Gly Leu Met Thr Tyr Arg Lys Ala Ile His Thr Val Val Gly Arg Pro
        275                 280                 285             
Ile Pro Val Arg Gln Thr Leu Asn Pro Thr Gln Glu Gln Ile Glu Glu
    290                 295                 300                 
Leu His Gln Thr Tyr Met Glu Glu Leu Arg Lys Leu Phe Glu Glu His
305                 310                 315                 320 
Lys Gly Lys Tyr Gly Ile Pro Glu His Glu Thr Leu Val Leu Lys
                325                 330                 335 


<210> 10
<211> 826
<212> PRT
<213> Homo sapiens

<220> 
<223> HIF1alpha

<300> 
<308> UniProt Q16665
<309> 1997-11-01  

<400> 10
Met Glu Gly Ala Gly Gly Ala Asn Asp Lys Lys Lys Ile Ser Ser Glu
 1               5                  10                  15      
Arg Arg Lys Glu Lys Ser Arg Asp Ala Ala Arg Ser Arg Arg Ser Lys
            20                  25                  30          
Glu Ser Glu Val Phe Tyr Glu Leu Ala His Gln Leu Pro Leu Pro His
        35                  40                  45              
Asn Val Ser Ser His Leu Asp Lys Ala Ser Val Met Arg Leu Thr Ile
    50                  55                  60                  
Ser Tyr Leu Arg Val Arg Lys Leu Leu Asp Ala Gly Asp Leu Asp Ile
65                  70                  75                  80  
Glu Asp Asp Met Lys Ala Gln Met Asn Cys Phe Tyr Leu Lys Ala Leu
                85                  90                  95      
Asp Gly Phe Val Met Val Leu Thr Asp Asp Gly Asp Met Ile Tyr Ile
            100                 105                 110         
Ser Asp Asn Val Asn Lys Tyr Met Gly Leu Thr Gln Phe Glu Leu Thr
        115                 120                 125             
Gly His Ser Val Phe Asp Phe Thr His Pro Cys Asp His Glu Glu Met
    130                 135                 140                 
Arg Glu Met Leu Thr His Arg Asn Gly Leu Val Lys Lys Gly Lys Glu
145                 150                 155                 160 
Gln Asn Thr Gln Arg Ser Phe Phe Leu Arg Met Lys Cys Thr Leu Thr
                165                 170                 175     
Ser Arg Gly Arg Thr Met Asn Ile Lys Ser Ala Thr Trp Lys Val Leu
            180                 185                 190         
His Cys Thr Gly His Ile His Val Tyr Asp Thr Asn Ser Asn Gln Pro
        195                 200                 205             
Gln Cys Gly Tyr Lys Lys Pro Pro Met Thr Cys Leu Val Leu Ile Cys
    210                 215                 220                 
Glu Pro Ile Pro His Pro Ser Asn Ile Glu Ile Pro Leu Asp Ser Lys
225                 230                 235                 240 
Thr Phe Leu Ser Arg His Ser Leu Asp Met Lys Phe Ser Tyr Cys Asp
                245                 250                 255     
Glu Arg Ile Thr Glu Leu Met Gly Tyr Glu Pro Glu Glu Leu Leu Gly
            260                 265                 270         
Arg Ser Ile Tyr Glu Tyr Tyr His Ala Leu Asp Ser Asp His Leu Thr
        275                 280                 285             
Lys Thr His His Asp Met Phe Thr Lys Gly Gln Val Thr Thr Gly Gln
    290                 295                 300                 
Tyr Arg Met Leu Ala Lys Arg Gly Gly Tyr Val Trp Val Glu Thr Gln
305                 310                 315                 320 
Ala Thr Val Ile Tyr Asn Thr Lys Asn Ser Gln Pro Gln Cys Ile Val
                325                 330                 335     
Cys Val Asn Tyr Val Val Ser Gly Ile Ile Gln His Asp Leu Ile Phe
            340                 345                 350         
Ser Leu Gln Gln Thr Glu Cys Val Leu Lys Pro Val Glu Ser Ser Asp
        355                 360                 365             
Met Lys Met Thr Gln Leu Phe Thr Lys Val Glu Ser Glu Asp Thr Ser
    370                 375                 380                 
Ser Leu Phe Asp Lys Leu Lys Lys Glu Pro Asp Ala Leu Thr Leu Leu
385                 390                 395                 400 
Ala Pro Ala Ala Gly Asp Thr Ile Ile Ser Leu Asp Phe Gly Ser Asn
                405                 410                 415     
Asp Thr Glu Thr Asp Asp Gln Gln Leu Glu Glu Val Pro Leu Tyr Asn
            420                 425                 430         
Asp Val Met Leu Pro Ser Pro Asn Glu Lys Leu Gln Asn Ile Asn Leu
        435                 440                 445             
Ala Met Ser Pro Leu Pro Thr Ala Glu Thr Pro Lys Pro Leu Arg Ser
    450                 455                 460                 
Ser Ala Asp Pro Ala Leu Asn Gln Glu Val Ala Leu Lys Leu Glu Pro
465                 470                 475                 480 
Asn Pro Glu Ser Leu Glu Leu Ser Phe Thr Met Pro Gln Ile Gln Asp
                485                 490                 495     
Gln Thr Pro Ser Pro Ser Asp Gly Ser Thr Arg Gln Ser Ser Pro Glu
            500                 505                 510         
Pro Asn Ser Pro Ser Glu Tyr Cys Phe Tyr Val Asp Ser Asp Met Val
        515                 520                 525             
Asn Glu Phe Lys Leu Glu Leu Val Glu Lys Leu Phe Ala Glu Asp Thr
    530                 535                 540                 
Glu Ala Lys Asn Pro Phe Ser Thr Gln Asp Thr Asp Leu Asp Leu Glu
545                 550                 555                 560 
Met Leu Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe Gln Leu Arg Ser
                565                 570                 575     
Phe Asp Gln Leu Ser Pro Leu Glu Ser Ser Ser Ala Ser Pro Glu Ser
            580                 585                 590         
Ala Ser Pro Gln Ser Thr Val Thr Val Phe Gln Gln Thr Gln Ile Gln
        595                 600                 605             
Glu Pro Thr Ala Asn Ala Thr Thr Thr Thr Ala Thr Thr Asp Glu Leu
    610                 615                 620                 
Lys Thr Val Thr Lys Asp Arg Met Glu Asp Ile Lys Ile Leu Ile Ala
625                 630                 635                 640 
Ser Pro Ser Pro Thr His Ile His Lys Glu Thr Thr Ser Ala Thr Ser
                645                 650                 655     
Ser Pro Tyr Arg Asp Thr Gln Ser Arg Thr Ala Ser Pro Asn Arg Ala
            660                 665                 670         
Gly Lys Gly Val Ile Glu Gln Thr Glu Lys Ser His Pro Arg Ser Pro
        675                 680                 685             
Asn Val Leu Ser Val Ala Leu Ser Gln Arg Thr Thr Val Pro Glu Glu
    690                 695                 700                 
Glu Leu Asn Pro Lys Ile Leu Ala Leu Gln Asn Ala Gln Arg Lys Arg
705                 710                 715                 720 
Lys Met Glu His Asp Gly Ser Leu Phe Gln Ala Val Gly Ile Gly Thr
                725                 730                 735     
Leu Leu Gln Gln Pro Asp Asp His Ala Ala Thr Thr Ser Leu Ser Trp
            740                 745                 750         
Lys Arg Val Lys Gly Cys Lys Ser Ser Glu Gln Asn Gly Met Glu Gln
        755                 760                 765             
Lys Thr Ile Ile Leu Ile Pro Ser Asp Leu Ala Cys Arg Leu Leu Gly
    770                 775                 780                 
Gln Ser Met Asp Glu Ser Gly Leu Pro Gln Leu Thr Ser Tyr Asp Cys
785                 790                 795                 800 
Glu Val Asn Ala Pro Ile Gln Gly Ser Arg Asn Leu Leu Gln Gly Glu
                805                 810                 815     
Glu Leu Leu Arg Ala Leu Asp Gln Val Asn
            820                 825     


<210> 11
<211> 488
<212> PRT
<213> Homo sapiens

<220> 
<223> DAG O-acetyltransferase 1 (DGAT1)

<300> 
<308> NCBI NP_036211.2
<309> 2007-04-27  

<400> 11
Met Gly Asp Arg Gly Ser Ser Arg Arg Arg Arg Thr Gly Ser Arg Pro
 1               5                  10                  15      
Ser Ser His Gly Gly Gly Gly Pro Ala Ala Ala Glu Glu Glu Val Arg
            20                  25                  30          
Asp Ala Ala Ala Gly Pro Asp Val Gly Ala Ala Gly Asp Ala Pro Ala
        35                  40                  45              
Pro Ala Pro Asn Lys Asp Gly Asp Ala Gly Val Gly Ser Gly His Trp
    50                  55                  60                  
Glu Leu Arg Cys His Arg Leu Gln Asp Ser Leu Phe Ser Ser Asp Ser
65                  70                  75                  80  
Gly Phe Ser Asn Tyr Arg Gly Ile Leu Asn Trp Cys Val Val Met Leu
                85                  90                  95      
Ile Leu Ser Asn Ala Arg Leu Phe Leu Glu Asn Leu Ile Lys Tyr Gly
            100                 105                 110         
Ile Leu Val Asp Pro Ile Gln Val Val Ser Leu Phe Leu Lys Asp Pro
        115                 120                 125             
Tyr Ser Trp Pro Ala Pro Cys Leu Val Ile Ala Ala Asn Val Phe Ala
    130                 135                 140                 
Val Ala Ala Phe Gln Val Glu Lys Arg Leu Ala Val Gly Ala Leu Thr
145                 150                 155                 160 
Glu Gln Ala Gly Leu Leu Leu His Val Ala Asn Leu Ala Thr Ile Leu
                165                 170                 175     
Cys Phe Pro Ala Ala Val Val Leu Leu Val Glu Ser Ile Thr Pro Val
            180                 185                 190         
Gly Ser Leu Leu Ala Leu Met Ala His Thr Ile Leu Phe Leu Lys Leu
        195                 200                 205             
Phe Ser Tyr Arg Asp Val Asn Ser Trp Cys Arg Arg Ala Arg Ala Lys
    210                 215                 220                 
Ala Ala Ser Ala Gly Lys Lys Ala Ser Ser Ala Ala Ala Pro His Thr
225                 230                 235                 240 
Val Ser Tyr Pro Asp Asn Leu Thr Tyr Arg Asp Leu Tyr Tyr Phe Leu
                245                 250                 255     
Phe Ala Pro Thr Leu Cys Tyr Glu Leu Asn Phe Pro Arg Ser Pro Arg
            260                 265                 270         
Ile Arg Lys Arg Phe Leu Leu Arg Arg Ile Leu Glu Met Leu Phe Phe
        275                 280                 285             
Thr Gln Leu Gln Val Gly Leu Ile Gln Gln Trp Met Val Pro Thr Ile
    290                 295                 300                 
Gln Asn Ser Met Lys Pro Phe Lys Asp Met Asp Tyr Ser Arg Ile Ile
305                 310                 315                 320 
Glu Arg Leu Leu Lys Leu Ala Val Pro Asn His Leu Ile Trp Leu Ile
                325                 330                 335     
Phe Phe Tyr Trp Leu Phe His Ser Cys Leu Asn Ala Val Ala Glu Leu
            340                 345                 350         
Met Gln Phe Gly Asp Arg Glu Phe Tyr Arg Asp Trp Trp Asn Ser Glu
        355                 360                 365             
Ser Val Thr Tyr Phe Trp Gln Asn Trp Asn Ile Pro Val His Lys Trp
    370                 375                 380                 
Cys Ile Arg His Phe Tyr Lys Pro Met Leu Arg Arg Gly Ser Ser Lys
385                 390                 395                 400 
Trp Met Ala Arg Thr Gly Val Phe Leu Ala Ser Ala Phe Phe His Glu
                405                 410                 415     
Tyr Leu Val Ser Val Pro Leu Arg Met Phe Arg Leu Trp Ala Phe Thr
            420                 425                 430         
Gly Met Met Ala Gln Ile Pro Leu Ala Trp Phe Val Gly Arg Phe Phe
        435                 440                 445             
Gln Gly Asn Tyr Gly Asn Ala Ala Val Trp Leu Ser Leu Ile Ile Gly
    450                 455                 460                 
Gln Pro Ile Ala Val Leu Met Tyr Val His Asp Tyr Tyr Val Leu Asn
465                 470                 475                 480 
Tyr Glu Ala Pro Ala Ala Glu Ala
                485             


<210> 12
<211> 622
<212> PRT
<213> Homo sapiens

<220> 
<223> PCK1

<300> 
<308> UniProt P35558
<309> 1994-06-01  

<400> 12
Met Pro Pro Gln Leu Gln Asn Gly Leu Asn Leu Ser Ala Lys Val Val
 1               5                  10                  15      
Gln Gly Ser Leu Asp Ser Leu Pro Gln Ala Val Arg Glu Phe Leu Glu
            20                  25                  30          
Asn Asn Ala Glu Leu Cys Gln Pro Asp His Ile His Ile Cys Asp Gly
        35                  40                  45              
Ser Glu Glu Glu Asn Gly Arg Leu Leu Gly Gln Met Glu Glu Glu Gly
    50                  55                  60                  
Ile Leu Arg Arg Leu Lys Lys Tyr Asp Asn Cys Trp Leu Ala Leu Thr
65                  70                  75                  80  
Asp Pro Arg Asp Val Ala Arg Ile Glu Ser Lys Thr Val Ile Val Thr
                85                  90                  95      
Gln Glu Gln Arg Asp Thr Val Pro Ile Pro Lys Thr Gly Leu Ser Gln
            100                 105                 110         
Leu Gly Arg Trp Met Ser Glu Glu Asp Phe Glu Lys Ala Phe Asn Ala
        115                 120                 125             
Arg Phe Pro Gly Cys Met Lys Gly Arg Thr Met Tyr Val Ile Pro Phe
    130                 135                 140                 
Ser Met Gly Pro Leu Gly Ser Pro Leu Ser Lys Ile Gly Ile Glu Leu
145                 150                 155                 160 
Thr Asp Ser Pro Tyr Val Val Ala Ser Met Arg Ile Met Thr Arg Met
                165                 170                 175     
Gly Thr Pro Val Leu Glu Ala Val Gly Asp Gly Glu Phe Val Lys Cys
            180                 185                 190         
Leu His Ser Val Gly Cys Pro Leu Pro Leu Gln Lys Pro Leu Val Asn
        195                 200                 205             
Asn Trp Pro Cys Asn Pro Glu Leu Thr Leu Ile Ala His Leu Pro Asp
    210                 215                 220                 
Arg Arg Glu Ile Ile Ser Phe Gly Ser Gly Tyr Gly Gly Asn Ser Leu
225                 230                 235                 240 
Leu Gly Lys Lys Cys Phe Ala Leu Arg Met Ala Ser Arg Leu Ala Lys
                245                 250                 255     
Glu Glu Gly Trp Leu Ala Glu His Met Leu Ile Leu Gly Ile Thr Asn
            260                 265                 270         
Pro Glu Gly Glu Lys Lys Tyr Leu Ala Ala Ala Phe Pro Ser Ala Cys
        275                 280                 285             
Gly Lys Thr Asn Leu Ala Met Met Asn Pro Ser Leu Pro Gly Trp Lys
    290                 295                 300                 
Val Glu Cys Val Gly Asp Asp Ile Ala Trp Met Lys Phe Asp Ala Gln
305                 310                 315                 320 
Gly His Leu Arg Ala Ile Asn Pro Glu Asn Gly Phe Phe Gly Val Ala
                325                 330                 335     
Pro Gly Thr Ser Val Lys Thr Asn Pro Asn Ala Ile Lys Thr Ile Gln
            340                 345                 350         
Lys Asn Thr Ile Phe Thr Asn Val Ala Glu Thr Ser Asp Gly Gly Val
        355                 360                 365             
Tyr Trp Glu Gly Ile Asp Glu Pro Leu Ala Ser Gly Val Thr Ile Thr
    370                 375                 380                 
Ser Trp Lys Asn Lys Glu Trp Ser Ser Glu Asp Gly Glu Pro Cys Ala
385                 390                 395                 400 
His Pro Asn Ser Arg Phe Cys Thr Pro Ala Ser Gln Cys Pro Ile Ile
                405                 410                 415     
Asp Ala Ala Trp Glu Ser Pro Glu Gly Val Pro Ile Glu Gly Ile Ile
            420                 425                 430         
Phe Gly Gly Arg Arg Pro Ala Gly Val Pro Leu Val Tyr Glu Ala Leu
        435                 440                 445             
Ser Trp Gln His Gly Val Phe Val Gly Ala Ala Met Arg Ser Glu Ala
    450                 455                 460                 
Thr Ala Ala Ala Glu His Lys Gly Lys Ile Ile Met His Asp Pro Phe
465                 470                 475                 480 
Ala Met Arg Pro Phe Phe Gly Tyr Asn Phe Gly Lys Tyr Leu Ala His
                485                 490                 495     
Trp Leu Ser Met Ala Gln His Pro Ala Ala Lys Leu Pro Lys Ile Phe
            500                 505                 510         
His Val Asn Trp Phe Arg Lys Asp Lys Glu Gly Lys Phe Leu Trp Pro
        515                 520                 525             
Gly Phe Gly Glu Asn Ser Arg Val Leu Glu Trp Met Phe Asn Arg Ile
    530                 535                 540                 
Asp Gly Lys Ala Ser Thr Lys Leu Thr Pro Ile Gly Tyr Ile Pro Lys
545                 550                 555                 560 
Glu Asp Ala Leu Asn Leu Lys Gly Leu Gly His Ile Asn Met Met Glu
                565                 570                 575     
Leu Phe Ser Ile Ser Lys Glu Phe Trp Glu Lys Glu Val Glu Asp Ile
            580                 585                 590         
Glu Lys Tyr Leu Glu Asp Gln Val Asn Ala Asp Leu Pro Cys Glu Ile
        595                 600                 605             
Glu Arg Glu Ile Leu Ala Leu Lys Gln Arg Ile Ser Gln Met
    610                 615                 620         


<210> 13
<211> 257
<212> PRT
<213> Homo sapiens

<220> 
<223> AGPAT1

<300> 
<308> UniProt Q99943
<309> 1998-12-15  

<400> 13
Phe Cys Ser Pro Ser Ala Lys Tyr Phe Phe Lys Met Ala Phe Tyr Asn
 1               5                  10                  15      
Gly Trp Ile Leu Phe Leu Ala Val Leu Ala Ile Pro Val Cys Ala Val
            20                  25                  30          
Arg Gly Arg Asn Val Glu Asn Met Lys Ile Leu Arg Leu Met Leu Leu
        35                  40                  45              
His Ile Lys Tyr Leu Tyr Gly Ile Arg Val Glu Val Arg Gly Ala His
    50                  55                  60                  
His Phe Pro Pro Ser Gln Pro Tyr Val Val Val Ser Asn His Gln Ser
65                  70                  75                  80  
Ser Leu Asp Leu Leu Gly Met Met Glu Val Leu Pro Gly Arg Cys Val
                85                  90                  95      
Pro Ile Ala Lys Arg Glu Leu Leu Trp Ala Gly Ser Ala Gly Leu Ala
            100                 105                 110         
Cys Trp Leu Ala Gly Val Ile Phe Ile Asp Arg Lys Arg Thr Gly Asp
        115                 120                 125             
Ala Ile Ser Val Met Ser Glu Val Ala Gln Thr Leu Leu Thr Gln Asp
    130                 135                 140                 
Val Arg Val Trp Val Phe Pro Glu Gly Thr Arg Asn His Asn Gly Ser
145                 150                 155                 160 
Met Leu Pro Phe Lys Arg Gly Ala Phe His Leu Ala Val Gln Ala Gln
                165                 170                 175     
Val Pro Ile Val Pro Ile Val Met Ser Ser Tyr Gln Asp Phe Tyr Cys
            180                 185                 190         
Lys Lys Glu Arg Arg Phe Thr Ser Gly Gln Cys Gln Val Arg Val Leu
        195                 200                 205             
Pro Pro Val Pro Thr Glu Gly Leu Thr Pro Asp Asp Val Pro Ala Leu
    210                 215                 220                 
Ala Asp Arg Val Arg His Ser Met Leu Thr Val Phe Arg Glu Ile Ser
225                 230                 235                 240 
Thr Asp Gly Arg Gly Gly Gly Asp Tyr Leu Lys Lys Pro Gly Gly Gly
                245                 250                 255     
Gly
    


<210> 14
<211> 255
<212> PRT
<213> Homo sapiens

<220> 
<223> AGPAT2 isoform alpha precursor

<300> 
<308> UniProt O15120
<309> 1998-12-15  

<400> 14
Ala Glu Phe Tyr Ala Lys Val Ala Leu Tyr Cys Ala Leu Cys Phe Thr
 1               5                  10                  15      
Val Ser Ala Val Ala Ser Leu Val Cys Leu Leu Arg His Gly Gly Arg
            20                  25                  30          
Thr Val Glu Asn Met Ser Ile Ile Gly Trp Phe Val Arg Ser Phe Lys
        35                  40                  45              
Tyr Phe Tyr Gly Leu Arg Phe Glu Val Arg Asp Pro Arg Arg Leu Gln
    50                  55                  60                  
Glu Ala Arg Pro Cys Val Ile Val Ser Asn His Gln Ser Ile Leu Asp
65                  70                  75                  80  
Met Met Gly Leu Met Glu Val Leu Pro Glu Arg Cys Val Gln Ile Ala
                85                  90                  95      
Lys Arg Glu Leu Leu Phe Leu Gly Pro Val Gly Leu Ile Met Tyr Leu
            100                 105                 110         
Gly Gly Val Phe Phe Ile Asn Arg Gln Arg Ser Ser Thr Ala Met Thr
        115                 120                 125             
Val Met Ala Asp Leu Gly Glu Arg Met Val Arg Glu Asn Leu Lys Val
    130                 135                 140                 
Trp Ile Tyr Pro Glu Gly Thr Arg Asn Asp Asn Gly Asp Leu Leu Pro
145                 150                 155                 160 
Phe Lys Lys Gly Ala Phe Tyr Leu Ala Val Gln Ala Gln Val Pro Ile
                165                 170                 175     
Val Pro Val Val Tyr Ser Ser Phe Ser Ser Phe Tyr Asn Thr Lys Lys
            180                 185                 190         
Lys Phe Phe Thr Ser Gly Thr Val Thr Val Gln Val Leu Glu Ala Ile
        195                 200                 205             
Pro Thr Ser Gly Leu Thr Ala Ala Asp Val Pro Ala Leu Val Asp Thr
    210                 215                 220                 
Cys His Arg Ala Met Arg Thr Thr Phe Leu His Ile Ser Lys Thr Pro
225                 230                 235                 240 
Gln Glu Asn Gly Ala Thr Ala Gly Ser Gly Val Gln Pro Ala Gln
                245                 250                 255 


<210> 15
<211> 223
<212> PRT
<213> Homo sapiens

<220> 
<223> AGPAT2 isoform beta precursor

<300> 
<308> NCBI NP_001012745.1
<309> 2008-07-01  

<400> 15
Ala Glu Phe Tyr Ala Lys Val Ala Leu Tyr Cys Ala Leu Cys Phe Thr
 1               5                  10                  15      
Val Ser Ala Val Ala Ser Leu Val Cys Leu Leu Arg His Gly Gly Arg
            20                  25                  30          
Thr Val Glu Asn Met Ser Ile Ile Gly Trp Phe Val Arg Ser Phe Lys
        35                  40                  45              
Tyr Phe Tyr Gly Leu Arg Phe Glu Val Arg Asp Pro Arg Arg Leu Gln
    50                  55                  60                  
Glu Ala Arg Pro Cys Val Ile Val Ser Asn His Gln Ser Ile Leu Asp
65                  70                  75                  80  
Met Met Gly Leu Met Glu Val Leu Pro Glu Arg Cys Val Gln Ile Ala
                85                  90                  95      
Lys Arg Glu Leu Leu Phe Leu Gly Pro Val Gly Leu Ile Met Tyr Leu
            100                 105                 110         
Gly Gly Val Phe Phe Ile Asn Arg Gln Arg Ser Ser Thr Ala Met Thr
        115                 120                 125             
Val Met Ala Asp Leu Gly Glu Arg Met Val Arg Glu Asn Val Pro Ile
    130                 135                 140                 
Val Pro Val Val Tyr Ser Ser Phe Ser Ser Phe Tyr Asn Thr Lys Lys
145                 150                 155                 160 
Lys Phe Phe Thr Ser Gly Thr Val Thr Val Gln Val Leu Glu Ala Ile
                165                 170                 175     
Pro Thr Ser Gly Leu Thr Ala Ala Asp Val Pro Ala Leu Val Asp Thr
            180                 185                 190         
Cys His Arg Ala Met Arg Thr Thr Phe Leu His Ile Ser Lys Thr Pro
        195                 200                 205             
Gln Glu Asn Gly Ala Thr Ala Gly Ser Gly Val Gln Pro Ala Gln
    210                 215                 220             


<210> 16
<211> 376
<212> PRT
<213> Homo sapiens

<220> 
<223> AGPAT3

<300> 
<308> UniProt Q9NRZ7
<309> 2001-01-11  

<400> 16
Met Gly Leu Leu Ala Phe Leu Lys Thr Gln Phe Val Leu His Leu Leu
 1               5                  10                  15      
Val Gly Phe Val Phe Val Val Ser Gly Leu Val Ile Asn Phe Val Gln
            20                  25                  30          
Leu Cys Thr Leu Ala Leu Trp Pro Val Ser Lys Gln Leu Tyr Arg Arg
        35                  40                  45              
Leu Asn Cys Arg Leu Ala Tyr Ser Leu Trp Ser Gln Leu Val Met Leu
    50                  55                  60                  
Leu Glu Trp Trp Ser Cys Thr Glu Cys Thr Leu Phe Thr Asp Gln Ala
65                  70                  75                  80  
Thr Val Glu Arg Phe Gly Lys Glu His Ala Val Ile Ile Leu Asn His
                85                  90                  95      
Asn Phe Glu Ile Asp Phe Leu Cys Gly Trp Thr Met Cys Glu Arg Phe
            100                 105                 110         
Gly Val Leu Gly Ser Ser Lys Val Leu Ala Lys Lys Glu Leu Leu Tyr
        115                 120                 125             
Val Pro Leu Ile Gly Trp Thr Trp Tyr Phe Leu Glu Ile Val Phe Cys
    130                 135                 140                 
Lys Arg Lys Trp Glu Glu Asp Arg Asp Thr Val Val Glu Gly Leu Arg
145                 150                 155                 160 
Arg Leu Ser Asp Tyr Pro Glu Tyr Met Trp Phe Leu Leu Tyr Cys Glu
                165                 170                 175     
Gly Thr Arg Phe Thr Glu Thr Lys His Arg Val Ser Met Glu Val Ala
            180                 185                 190         
Ala Ala Lys Gly Leu Pro Val Leu Lys Tyr His Leu Leu Pro Arg Thr
        195                 200                 205             
Lys Gly Phe Thr Thr Ala Val Lys Cys Leu Arg Gly Thr Val Ala Ala
    210                 215                 220                 
Val Tyr Asp Val Thr Leu Asn Phe Arg Gly Asn Lys Asn Pro Ser Leu
225                 230                 235                 240 
Leu Gly Ile Leu Tyr Gly Lys Lys Tyr Glu Ala Asp Met Cys Val Arg
                245                 250                 255     
Arg Phe Pro Leu Glu Asp Ile Pro Leu Asp Glu Lys Glu Ala Ala Gln
            260                 265                 270         
Trp Leu His Lys Leu Tyr Gln Glu Lys Asp Ala Leu Gln Glu Ile Tyr
        275                 280                 285             
Asn Gln Lys Gly Met Phe Pro Gly Glu Gln Phe Lys Pro Ala Arg Arg
    290                 295                 300                 
Pro Trp Thr Leu Leu Asn Phe Leu Ser Trp Ala Thr Ile Leu Leu Ser
305                 310                 315                 320 
Pro Leu Phe Ser Phe Val Leu Gly Val Phe Ala Ser Gly Ser Pro Leu
                325                 330                 335     
Leu Ile Leu Thr Phe Leu Gly Phe Val Gly Ala Ala Ser Phe Gly Val
            340                 345                 350         
Arg Arg Leu Ile Gly Val Thr Glu Ile Glu Lys Gly Ser Ser Tyr Gly
        355                 360                 365             
Asn Gln Glu Phe Lys Lys Lys Glu
    370                 375     


<210> 17
<211> 368
<212> PRT
<213> Homo sapiens

<220> 
<223> AGPAT3

<300> 
<308> GenBank AAQ89067.1
<309> 2003-10-03  

<400> 17
Met Gly Leu Leu Ala Phe Leu Lys Thr Gln Phe Val Leu His Leu Leu
 1               5                  10                  15      
Val Gly Phe Val Phe Val Val Ser Gly Leu Val Ile Asn Phe Val Gln
            20                  25                  30          
Leu Cys Thr Leu Ala Leu Trp Pro Val Ser Lys Gln Leu Tyr Arg Arg
        35                  40                  45              
Leu Asn Cys Arg Leu Ala Tyr Ser Leu Trp Ser Gln Leu Val Met Leu
    50                  55                  60                  
Leu Glu Trp Trp Ser Cys Thr Glu Cys Thr Leu Phe Thr Asp Gln Ala
65                  70                  75                  80  
Thr Val Glu Arg Phe Gly Lys Glu His Ala Val Ile Ile Leu Asn His
                85                  90                  95      
Asn Phe Glu Ile Asp Phe Leu Cys Gly Trp Thr Met Cys Glu Arg Phe
            100                 105                 110         
Gly Val Leu Gly Ser Ser Lys Val Leu Ala Lys Lys Glu Leu Leu Tyr
        115                 120                 125             
Val Pro Leu Ile Gly Trp Thr Trp Tyr Phe Leu Glu Ile Val Phe Cys
    130                 135                 140                 
Lys Arg Lys Trp Glu Glu Asp Arg Asp Thr Val Val Glu Gly Leu Arg
145                 150                 155                 160 
Arg Leu Ser Asp Tyr Pro Glu Tyr Met Trp Phe Leu Leu Tyr Cys Glu
                165                 170                 175     
Gly Thr Arg Phe Thr Glu Thr Lys His Arg Val Ser Met Glu Val Ala
            180                 185                 190         
Ala Ala Lys Gly Leu Pro Val Leu Lys Tyr His Leu Leu Pro Arg Thr
        195                 200                 205             
Lys Gly Phe Thr Thr Ala Val Lys Cys Leu Arg Gly Thr Val Ala Ala
    210                 215                 220                 
Val Tyr Asp Val Thr Leu Asn Phe Arg Gly Asn Lys Asn Pro Ser Leu
225                 230                 235                 240 
Leu Gly Ile Leu Tyr Gly Lys Lys Tyr Glu Ala Asp Met Cys Val Arg
                245                 250                 255     
Arg Phe Pro Leu Glu Asp Ile Pro Leu Asp Glu Lys Glu Ala Ala Gln
            260                 265                 270         
Trp Leu His Lys Leu Tyr Gln Glu Lys Asp Ala Leu Gln Glu Ile Tyr
        275                 280                 285             
Asn Gln Lys Gly Met Phe Pro Gly Glu Gln Phe Lys Pro Ala Arg Arg
    290                 295                 300                 
Pro Trp Thr Leu Leu Asn Phe Leu Ser Trp Ala Thr Ile Leu Leu Ser
305                 310                 315                 320 
Pro Leu Phe Ser Phe Val Leu Gly Val Phe Ala Ser Gly Ser Pro Leu
                325                 330                 335     
Leu Ile Leu Thr Phe Leu Gly Phe Val Gly Ala Ala Ser Phe Gly Val
            340                 345                 350         
Arg Arg Leu Ile Gly Glu Ser Leu Glu Pro Gly Arg Trp Arg Leu Gln
        355                 360                 365             


<210> 18
<211> 419
<212> PRT
<213> Homo sapiens

<220> 
<223> AGPAT6 (LPA-MAG PA)

<300> 
<308> UniProt Q86UL3
<309> 2005-06-21  

<400> 18
Val Ser Phe Gly Ile Arg Lys Leu Tyr Met Lys Ser Leu Leu Lys Ile
 1               5                  10                  15      
Phe Ala Trp Ala Thr Leu Arg Met Glu Arg Gly Ala Lys Glu Lys Asn
            20                  25                  30          
His Gln Leu Tyr Lys Pro Tyr Thr Asn Gly Ile Ile Ala Lys Asp Pro
        35                  40                  45              
Thr Ser Leu Glu Glu Glu Ile Lys Glu Ile Arg Arg Ser Gly Ser Ser
    50                  55                  60                  
Lys Ala Leu Asp Asn Thr Pro Glu Phe Glu Leu Ser Asp Ile Phe Tyr
65                  70                  75                  80  
Phe Cys Arg Lys Gly Met Glu Thr Ile Met Asp Asp Glu Val Thr Lys
                85                  90                  95      
Arg Phe Ser Ala Glu Glu Leu Glu Ser Trp Asn Leu Leu Ser Arg Thr
            100                 105                 110         
Asn Tyr Asn Phe Gln Tyr Ile Ser Leu Arg Leu Thr Val Leu Trp Gly
        115                 120                 125             
Leu Gly Val Leu Ile Arg Tyr Cys Phe Leu Leu Pro Leu Arg Ile Ala
    130                 135                 140                 
Leu Ala Phe Thr Gly Ile Ser Leu Leu Val Val Gly Thr Thr Val Val
145                 150                 155                 160 
Gly Tyr Leu Pro Asn Gly Arg Phe Lys Glu Phe Met Ser Lys His Val
                165                 170                 175     
His Leu Met Cys Tyr Arg Ile Cys Val Arg Ala Leu Thr Ala Ile Ile
            180                 185                 190         
Thr Tyr His Asp Arg Glu Asn Arg Pro Arg Asn Gly Gly Ile Cys Val
        195                 200                 205             
Ala Asn His Thr Ser Pro Ile Asp Val Ile Ile Leu Ala Ser Asp Gly
    210                 215                 220                 
Tyr Tyr Ala Met Val Gly Gln Val His Gly Gly Leu Met Gly Val Ile
225                 230                 235                 240 
Gln Arg Ala Met Val Lys Ala Cys Pro His Val Trp Phe Glu Arg Ser
                245                 250                 255     
Glu Val Lys Asp Arg His Leu Val Ala Lys Arg Leu Thr Glu His Val
            260                 265                 270         
Gln Asp Lys Ser Lys Leu Pro Ile Leu Ile Phe Pro Glu Gly Thr Cys
        275                 280                 285             
Ile Asn Asn Thr Ser Val Met Met Phe Lys Lys Gly Ser Phe Glu Ile
    290                 295                 300                 
Gly Ala Thr Val Tyr Pro Val Ala Ile Lys Tyr Asp Pro Gln Phe Gly
305                 310                 315                 320 
Asp Ala Phe Trp Asn Ser Ser Lys Tyr Gly Met Val Thr Tyr Leu Leu
                325                 330                 335     
Arg Met Met Thr Ser Trp Ala Ile Val Cys Ser Val Trp Tyr Leu Pro
            340                 345                 350         
Pro Met Thr Arg Glu Ala Asp Glu Asp Ala Val Gln Phe Ala Asn Arg
        355                 360                 365             
Val Lys Ser Ala Ile Ala Arg Gln Gly Gly Leu Val Asp Leu Leu Trp
    370                 375                 380                 
Asp Gly Gly Leu Lys Arg Glu Lys Val Lys Asp Thr Phe Lys Glu Glu
385                 390                 395                 400 
Gln Gln Lys Leu Tyr Ser Lys Met Ile Val Gly Asn His Lys Asp Arg
                405                 410                 415     
Ser Arg Ser
            


<210> 19
<211> 795
<212> PRT
<213> Homo sapiens

<220> 
<223> GPAT2

<300> 
<308> UniProt Q6NUI2
<309> 2008-03-18  

<400> 19
Met Ala Thr Met Leu Glu Gly Arg Cys Gln Thr Gln Pro Arg Ser Ser
 1               5                  10                  15      
Pro Ser Gly Arg Glu Ala Ser Leu Trp Ser Ser Gly Phe Gly Met Lys
            20                  25                  30          
Leu Glu Ala Val Thr Pro Phe Leu Gly Lys Tyr Arg Pro Phe Val Gly
        35                  40                  45              
Arg Cys Cys Gln Thr Cys Thr Pro Lys Ser Trp Glu Ser Leu Phe His
    50                  55                  60                  
Arg Ser Ile Thr Asp Leu Gly Phe Cys Asn Val Ile Leu Val Lys Glu
65                  70                  75                  80  
Glu Asn Thr Arg Phe Arg Gly Trp Leu Val Arg Arg Leu Cys Tyr Phe
                85                  90                  95      
Leu Trp Ser Leu Glu Gln His Ile Pro Pro Cys Gln Asp Val Pro Gln
            100                 105                 110         
Lys Ile Met Glu Ser Thr Gly Val Gln Asn Leu Leu Ser Gly Arg Val
        115                 120                 125             
Pro Gly Gly Thr Gly Glu Gly Gln Val Pro Asp Leu Val Lys Lys Glu
    130                 135                 140                 
Val Gln Arg Ile Leu Gly His Ile Gln Ala Pro Pro Arg Pro Phe Leu
145                 150                 155                 160 
Val Arg Leu Phe Ser Trp Ala Leu Leu Arg Phe Leu Asn Cys Leu Phe
                165                 170                 175     
Leu Asn Val Gln Leu His Lys Gly Gln Met Lys Met Val Gln Lys Ala
            180                 185                 190         
Ala Gln Ala Gly Leu Pro Leu Val Leu Leu Ser Thr His Lys Thr Leu
        195                 200                 205             
Leu Asp Gly Ile Leu Leu Pro Phe Met Leu Leu Ser Gln Gly Leu Gly
    210                 215                 220                 
Val Leu Arg Val Ala Trp Asp Ser Arg Ala Cys Ser Pro Ala Leu Arg
225                 230                 235                 240 
Ala Leu Leu Arg Lys Leu Gly Gly Leu Phe Leu Pro Pro Glu Ala Ser
                245                 250                 255     
Leu Ser Leu Asp Ser Ser Glu Gly Leu Leu Ala Arg Ala Val Val Gln
            260                 265                 270         
Ala Val Ile Glu Gln Leu Leu Val Ser Gly Gln Pro Leu Leu Ile Phe
        275                 280                 285             
Leu Glu Glu Pro Pro Gly Ala Leu Gly Pro Arg Leu Ser Ala Leu Gly
    290                 295                 300                 
Gln Ala Trp Val Gly Phe Val Val Gln Ala Val Gln Val Gly Ile Val
305                 310                 315                 320 
Pro Asp Ala Leu Leu Val Pro Val Ala Val Thr Tyr Asp Leu Val Pro
                325                 330                 335     
Asp Ala Pro Cys Asp Ile Asp His Ala Ser Ala Pro Leu Gly Leu Trp
            340                 345                 350         
Thr Gly Ala Leu Ala Val Leu Arg Ser Leu Trp Ser Arg Trp Gly Cys
        355                 360                 365             
Ser His Arg Ile Cys Ser Arg Val His Leu Ala Gln Pro Phe Ser Leu
    370                 375                 380                 
Gln Glu Tyr Ile Val Ser Ala Arg Ser Cys Trp Gly Gly Arg Gln Thr
385                 390                 395                 400 
Leu Glu Gln Leu Leu Gln Pro Ile Val Leu Gly Gln Cys Thr Ala Val
                405                 410                 415     
Pro Asp Thr Glu Lys Glu Gln Glu Trp Thr Pro Ile Thr Gly Pro Leu
            420                 425                 430         
Leu Ala Leu Lys Glu Glu Asp Gln Leu Leu Val Arg Arg Leu Ser Cys
        435                 440                 445             
His Val Leu Ser Ala Ser Val Gly Ser Ser Ala Val Met Ser Thr Ala
    450                 455                 460                 
Ile Met Ala Thr Leu Leu Leu Phe Lys His Gln Lys Leu Leu Gly Glu
465                 470                 475                 480 
Phe Ser Trp Leu Thr Glu Glu Ile Leu Leu Arg Gly Phe Asp Val Gly
                485                 490                 495     
Phe Ser Gly Gln Leu Arg Ser Leu Leu Gln His Ser Leu Ser Leu Leu
            500                 505                 510         
Arg Ala His Val Ala Leu Leu Arg Ile Arg Gln Gly Asp Leu Leu Val
        515                 520                 525             
Val Pro Gln Pro Gly Pro Gly Leu Thr His Leu Ala Gln Leu Ser Ala
    530                 535                 540                 
Glu Leu Leu Pro Val Phe Leu Ser Glu Ala Val Gly Ala Cys Ala Val
545                 550                 555                 560 
Arg Gly Leu Leu Ala Gly Arg Val Pro Pro Gln Gly Pro Trp Glu Leu
                565                 570                 575     
Gln Gly Ile Leu Leu Leu Ser Gln Asn Glu Leu Tyr Arg Gln Ile Leu
            580                 585                 590         
Leu Leu Met His Leu Leu Pro Gln Asp Leu Leu Leu Leu Lys Pro Cys
        595                 600                 605             
Gln Ser Ser Tyr Cys Tyr Cys Gln Glu Val Leu Asp Arg Leu Ile Gln
    610                 615                 620                 
Cys Gly Leu Leu Val Ala Glu Glu Thr Pro Gly Ser Arg Pro Ala Cys
625                 630                 635                 640 
Asp Thr Gly Arg Gln Arg Leu Ser Arg Lys Leu Leu Trp Lys Pro Ser
                645                 650                 655     
Gly Asp Phe Thr Asp Ser Asp Ser Asp Asp Phe Gly Glu Ala Asp Gly
            660                 665                 670         
Arg Tyr Phe Arg Leu Ser Gln Gln Ser His Cys Pro Asp Phe Phe Leu
        675                 680                 685             
Phe Leu Cys Arg Leu Leu Ser Pro Leu Leu Lys Ala Phe Ala Gln Ala
    690                 695                 700                 
Ala Ala Phe Leu Arg Gln Gly Gln Leu Pro Asp Thr Glu Leu Gly Tyr
705                 710                 715                 720 
Thr Glu Gln Leu Phe Gln Phe Leu Gln Ala Thr Ala Gln Glu Glu Gly
                725                 730                 735     
Ile Phe Glu Cys Ala Asp Pro Lys Leu Ala Ile Ser Ala Val Trp Thr
            740                 745                 750         
Phe Arg Asp Leu Gly Val Leu Gln Gln Thr Pro Ser Pro Ala Gly Pro
        755                 760                 765             
Arg Leu His Leu Ser Pro Thr Phe Ala Ser Leu Asp Asn Gln Glu Lys
    770                 775                 780                 
Leu Glu Gln Phe Ile Arg Gln Phe Ile Cys Ser
785                 790                 795 


<210> 20
<211> 334
<212> PRT
<213> Homo sapiens

<220> 
<223> MOGAT2

<300> 
<308> UniProt Q3SYC2
<309> 2006-09-05  

<400> 20
Met Val Glu Phe Ala Pro Leu Phe Met Pro Trp Glu Arg Arg Leu Gln
 1               5                  10                  15      
Thr Leu Ala Val Leu Gln Phe Val Phe Ser Phe Leu Ala Leu Ala Glu
            20                  25                  30          
Ile Cys Thr Val Gly Phe Ile Ala Leu Leu Phe Thr Arg Phe Trp Leu
        35                  40                  45              
Leu Thr Val Leu Tyr Ala Ala Trp Trp Tyr Leu Asp Arg Asp Lys Pro
    50                  55                  60                  
Arg Gln Gly Gly Arg His Ile Gln Ala Ile Arg Cys Trp Thr Ile Trp
65                  70                  75                  80  
Lys Tyr Met Lys Asp Tyr Phe Pro Ile Ser Leu Val Lys Thr Ala Glu
                85                  90                  95      
Leu Asp Pro Ser Arg Asn Tyr Ile Ala Gly Phe His Pro His Gly Val
            100                 105                 110         
Leu Ala Val Gly Ala Phe Ala Asn Leu Cys Thr Glu Ser Thr Gly Phe
        115                 120                 125             
Ser Ser Ile Phe Pro Gly Ile Arg Pro His Leu Met Met Leu Thr Leu
    130                 135                 140                 
Trp Phe Arg Ala Pro Phe Phe Arg Asp Tyr Ile Met Ser Ala Gly Leu
145                 150                 155                 160 
Val Thr Ser Glu Lys Glu Ser Ala Ala His Ile Leu Asn Arg Lys Gly
                165                 170                 175     
Gly Gly Asn Leu Leu Gly Ile Ile Val Gly Gly Ala Gln Glu Ala Leu
            180                 185                 190         
Asp Ala Arg Pro Gly Ser Phe Thr Leu Leu Leu Arg Asn Arg Lys Gly
        195                 200                 205             
Phe Val Arg Leu Ala Leu Thr His Gly Ala Pro Leu Val Pro Ile Phe
    210                 215                 220                 
Ser Phe Gly Glu Asn Asp Leu Phe Asp Gln Ile Pro Asn Ser Ser Gly
225                 230                 235                 240 
Ser Trp Leu Arg Tyr Ile Gln Asn Arg Leu Gln Lys Ile Met Gly Ile
                245                 250                 255     
Ser Leu Pro Leu Phe His Gly Arg Gly Val Phe Gln Tyr Ser Phe Gly
            260                 265                 270         
Leu Ile Pro Tyr Arg Arg Pro Ile Thr Thr Val Val Gly Lys Pro Ile
        275                 280                 285             
Glu Val Gln Lys Thr Leu His Pro Ser Glu Glu Glu Val Asn Gln Leu
    290                 295                 300                 
His Gln Arg Tyr Ile Lys Glu Leu Cys Asn Leu Phe Glu Ala His Lys
305                 310                 315                 320 
Leu Lys Phe Asn Ile Pro Ala Asp Gln His Leu Glu Phe Cys
                325                 330                 


<210> 21
<211> 284
<212> PRT
<213> Homo sapiens

<220> 
<223> MOGAT2

<300> 
<308> GenBank AAI03879.1
<309> 2006-10-04  

<400> 21
Met Val Glu Phe Ala Pro Leu Phe Met Pro Trp Glu Arg Arg Leu Gln
 1               5                  10                  15      
Thr Leu Ala Val Leu Gln Phe Val Phe Ser Phe Leu Ala Leu Ala Glu
            20                  25                  30          
Ile Cys Thr Val Gly Phe Ile Ala Leu Leu Phe Thr Arg Phe Trp Leu
        35                  40                  45              
Leu Thr Val Leu Tyr Ala Ala Trp Trp Tyr Leu Asp Arg Asp Lys Pro
    50                  55                  60                  
Arg Gln Gly Gly Arg His Ile Gln Ala Ile Arg Cys Trp Thr Ile Trp
65                  70                  75                  80  
Lys Tyr Met Lys Asp Tyr Phe Pro Ile Ser Leu Val Lys Thr Ala Glu
                85                  90                  95      
Leu Asp Pro Ser Arg Asn Tyr Ile Ala Gly Phe His Pro His Gly Val
            100                 105                 110         
Leu Ala Val Gly Ala Phe Ala Asn Leu Cys Thr Glu Ser Thr Gly Phe
        115                 120                 125             
Ser Ser Ile Phe Pro Gly Ile Arg Pro His Leu Met Met Leu Thr Leu
    130                 135                 140                 
Trp Phe Arg Ala Pro Phe Phe Arg Asp Tyr Ile Met Ser Ala Gly Leu
145                 150                 155                 160 
Val Thr Ser Glu Lys Glu Ser Ala Ala His Ile Leu Asn Arg Lys Gly
                165                 170                 175     
Gly Gly Asn Leu Leu Gly Ile Ile Val Gly Gly Ala Gln Glu Ala Leu
            180                 185                 190         
Asp Ala Arg Pro Gly Ser Phe Thr Leu Leu Leu Arg Asn Arg Lys Gly
        195                 200                 205             
Phe Val Arg Leu Ala Leu Thr His Gly Tyr Gln Ala Ser Gly Lys Ser
    210                 215                 220                 
Thr Leu Gly Ser Val Gly Asn Trp Gln Gly Phe Tyr Phe Gly Gly Lys
225                 230                 235                 240 
Met Ala Glu Thr Asn Ala Asp Ser Ile Leu Val Glu Ile Phe Ser Pro
                245                 250                 255     
Phe Thr Ile Lys Ile Ile Phe Trp Cys Leu Met Pro Lys Tyr Leu Glu
            260                 265                 270         
Lys Phe Pro Gln Arg Arg Leu Ser Asp Leu Arg Asn
        275                 280                 


<210> 22
<211> 388
<212> PRT
<213> Homo sapiens

<220> 
<223> DGAT2

<300> 
<308> UniProt Q96PD7
<309> 2006-09-05  

<400> 22
Met Lys Thr Leu Ile Ala Ala Tyr Ser Gly Val Leu Arg Gly Glu Arg
 1               5                  10                  15      
Gln Ala Glu Ala Asp Arg Ser Gln Arg Ser His Gly Gly Pro Ala Leu
            20                  25                  30          
Ser Arg Glu Gly Ser Gly Arg Trp Gly Thr Gly Ser Ser Ile Leu Ser
        35                  40                  45              
Ala Leu Gln Asp Leu Phe Ser Val Thr Trp Leu Asn Arg Ser Lys Val
    50                  55                  60                  
Glu Lys Gln Leu Gln Val Ile Ser Val Leu Gln Trp Val Leu Ser Phe
65                  70                  75                  80  
Leu Val Leu Gly Val Ala Cys Ser Ala Ile Leu Met Tyr Ile Phe Cys
                85                  90                  95      
Thr Asp Cys Trp Leu Ile Ala Val Leu Tyr Phe Thr Trp Leu Val Phe
            100                 105                 110         
Asp Trp Asn Thr Pro Lys Lys Gly Gly Arg Arg Ser Gln Trp Val Arg
        115                 120                 125             
Asn Trp Ala Val Trp Arg Tyr Phe Arg Asp Tyr Phe Pro Ile Gln Leu
    130                 135                 140                 
Val Lys Thr His Asn Leu Leu Thr Thr Arg Asn Tyr Ile Phe Gly Tyr
145                 150                 155                 160 
His Pro His Gly Ile Met Gly Leu Gly Ala Phe Cys Asn Phe Ser Thr
                165                 170                 175     
Glu Ala Thr Glu Val Ser Lys Lys Phe Pro Gly Ile Arg Pro Tyr Leu
            180                 185                 190         
Ala Thr Leu Ala Gly Asn Phe Arg Met Pro Val Leu Arg Glu Tyr Leu
        195                 200                 205             
Met Ser Gly Gly Ile Cys Pro Val Ser Arg Asp Thr Ile Asp Tyr Leu
    210                 215                 220                 
Leu Ser Lys Asn Gly Ser Gly Asn Ala Ile Ile Ile Val Val Gly Gly
225                 230                 235                 240 
Ala Ala Glu Ser Leu Ser Ser Met Pro Gly Lys Asn Ala Val Thr Leu
                245                 250                 255     
Arg Asn Arg Lys Gly Phe Val Lys Leu Ala Leu Arg His Gly Ala Asp
            260                 265                 270         
Leu Val Pro Ile Tyr Ser Phe Gly Glu Asn Glu Val Tyr Lys Gln Val
        275                 280                 285             
Ile Phe Glu Glu Gly Ser Trp Gly Arg Trp Val Gln Lys Lys Phe Gln
    290                 295                 300                 
Lys Tyr Ile Gly Phe Ala Pro Cys Ile Phe His Gly Arg Gly Leu Phe
305                 310                 315                 320 
Ser Ser Asp Thr Trp Gly Leu Val Pro Tyr Ser Lys Pro Ile Thr Thr
                325                 330                 335     
Val Val Gly Glu Pro Ile Thr Ile Pro Lys Leu Glu His Pro Thr Gln
            340                 345                 350         
Gln Asp Ile Asp Leu Tyr His Thr Met Tyr Met Glu Ala Leu Val Lys
        355                 360                 365             
Leu Phe Asp Lys His Lys Thr Lys Phe Gly Leu Pro Glu Thr Glu Val
    370                 375                 380                 
Leu Glu Val Asn
385             


<210> 23
<211> 295
<212> PRT
<213> Homo sapiens

<220> 
<223> AQP9

<300> 
<308> UniProt O43315
<309> 1998-12-15  

<400> 23
Met Gln Pro Glu Gly Ala Glu Lys Gly Lys Ser Phe Lys Gln Arg Leu
 1               5                  10                  15      
Val Leu Lys Ser Ser Leu Ala Lys Glu Thr Leu Ser Glu Phe Leu Gly
            20                  25                  30          
Thr Phe Ile Leu Ile Val Leu Gly Cys Gly Cys Val Ala Gln Ala Ile
        35                  40                  45              
Leu Ser Arg Gly Arg Phe Gly Gly Val Ile Thr Ile Asn Val Gly Phe
    50                  55                  60                  
Ser Met Ala Val Ala Met Ala Ile Tyr Val Ala Gly Gly Val Ser Gly
65                  70                  75                  80  
Gly His Ile Asn Pro Ala Val Ser Leu Ala Met Cys Leu Phe Gly Arg
                85                  90                  95      
Met Lys Trp Phe Lys Leu Pro Phe Tyr Val Gly Ala Gln Phe Leu Gly
            100                 105                 110         
Ala Phe Val Gly Ala Ala Thr Val Phe Gly Ile Tyr Tyr Asp Gly Leu
        115                 120                 125             
Met Ser Phe Ala Gly Gly Lys Leu Leu Ile Val Gly Glu Asn Ala Thr
    130                 135                 140                 
Ala His Ile Phe Ala Thr Tyr Pro Ala Pro Tyr Leu Ser Leu Ala Asn
145                 150                 155                 160 
Ala Phe Ala Asp Gln Val Val Ala Thr Met Ile Leu Leu Ile Ile Val
                165                 170                 175     
Phe Ala Ile Phe Asp Ser Arg Asn Leu Gly Ala Pro Arg Gly Leu Glu
            180                 185                 190         
Pro Ile Ala Ile Gly Leu Leu Ile Ile Val Ile Ala Ser Ser Leu Gly
        195                 200                 205             
Leu Asn Ser Gly Cys Ala Met Asn Pro Ala Arg Asp Leu Ser Pro Arg
    210                 215                 220                 
Leu Phe Thr Ala Leu Ala Gly Trp Gly Phe Glu Val Phe Arg Ala Gly
225                 230                 235                 240 
Asn Asn Phe Trp Trp Ile Pro Val Val Gly Pro Leu Val Gly Ala Val
                245                 250                 255     
Ile Gly Gly Leu Ile Tyr Val Leu Val Ile Glu Ile His His Pro Glu
            260                 265                 270         
Pro Asp Ser Val Phe Lys Thr Glu Gln Ser Glu Asp Lys Pro Glu Lys
        275                 280                 285             
Tyr Glu Leu Ser Val Ile Met
    290                 295 


<210> 24
<211> 890
<212> PRT
<213> Homo sapiens

<220> 
<223> LPIN1 (Lipin 1)

<300> 
<308> UniProt Q14693
<309> 1997-11-01  

<400> 24
Met Asn Tyr Val Gly Gln Leu Ala Gly Gln Val Phe Val Thr Val Lys
 1               5                  10                  15      
Glu Leu Tyr Lys Gly Leu Asn Pro Ala Thr Leu Ser Gly Cys Ile Asp
            20                  25                  30          
Ile Ile Val Ile Arg Gln Pro Asn Gly Asn Leu Gln Cys Ser Pro Phe
        35                  40                  45              
His Val Arg Phe Gly Lys Met Gly Val Leu Arg Ser Arg Glu Lys Val
    50                  55                  60                  
Val Asp Ile Glu Ile Asn Gly Glu Ser Val Asp Leu His Met Lys Leu
65                  70                  75                  80  
Gly Asp Asn Gly Glu Ala Phe Phe Val Gln Glu Thr Asp Asn Asp Gln
                85                  90                  95      
Glu Val Ile Pro Met His Leu Ala Thr Ser Pro Ile Leu Ser Glu Gly
            100                 105                 110         
Ala Ser Arg Met Glu Cys Gln Leu Lys Arg Gly Ser Val Asp Arg Met
        115                 120                 125             
Arg Gly Leu Asp Pro Ser Thr Pro Ala Gln Val Ile Ala Pro Ser Glu
    130                 135                 140                 
Thr Pro Ser Ser Ser Ser Val Val Lys Lys Arg Arg Lys Arg Arg Arg
145                 150                 155                 160 
Lys Ser Gln Leu Asp Ser Leu Lys Arg Asp Asp Asn Met Asn Thr Ser
                165                 170                 175     
Glu Asp Glu Asp Met Phe Pro Ile Glu Met Ser Ser Asp Glu Ala Met
            180                 185                 190         
Glu Leu Leu Glu Ser Ser Arg Thr Leu Pro Asn Asp Ile Pro Pro Phe
        195                 200                 205             
Gln Asp Asp Ile Pro Glu Glu Asn Leu Ser Leu Ala Val Ile Tyr Pro
    210                 215                 220                 
Gln Ser Ala Ser Tyr Pro Asn Ser Asp Arg Glu Trp Ser Pro Thr Pro
225                 230                 235                 240 
Ser Pro Ser Gly Ser Arg Pro Ser Thr Pro Lys Ser Asp Ser Glu Leu
                245                 250                 255     
Val Ser Lys Ser Thr Glu Arg Thr Gly Gln Lys Asn Pro Glu Met Leu
            260                 265                 270         
Trp Leu Trp Gly Glu Leu Pro Gln Ala Ala Lys Ser Ser Ser Pro His
        275                 280                 285             
Lys Met Lys Glu Ser Ser Pro Leu Ser Ser Arg Lys Ile Cys Asp Lys
    290                 295                 300                 
Ser His Phe Gln Ala Ile His Ser Glu Ser Ser Asp Thr Phe Ser Asp
305                 310                 315                 320 
Gln Ser Pro Thr Leu Val Gly Gly Ala Leu Leu Asp Gln Asn Lys Pro
                325                 330                 335     
Gln Thr Glu Met Gln Phe Val Asn Glu Glu Asp Leu Glu Thr Leu Gly
            340                 345                 350         
Ala Ala Ala Pro Leu Leu Pro Met Ile Glu Glu Leu Lys Pro Pro Ser
        355                 360                 365             
Ala Ser Val Val Gln Thr Ala Asn Lys Thr Asp Ser Pro Ser Arg Lys
    370                 375                 380                 
Arg Asp Lys Arg Ser Arg His Leu Gly Ala Asp Gly Val Tyr Leu Asp
385                 390                 395                 400 
Asp Leu Thr Asp Met Asp Pro Glu Val Ala Ala Leu Tyr Phe Pro Lys
                405                 410                 415     
Asn Gly Asp Pro Ser Gly Leu Ala Lys His Ala Ser Asp Asn Gly Ala
            420                 425                 430         
Arg Ser Ala Asn Gln Ser Pro Gln Ser Val Gly Ser Ser Gly Val Asp
        435                 440                 445             
Ser Gly Val Glu Ser Thr Ser Asp Gly Leu Arg Asp Leu Pro Ser Ile
    450                 455                 460                 
Ala Ile Ser Leu Cys Gly Gly Leu Ser Asp His Arg Glu Ile Thr Lys
465                 470                 475                 480 
Asp Ala Phe Leu Glu Gln Ala Val Ser Tyr Gln Gln Phe Val Asp Asn
                485                 490                 495     
Pro Ala Ile Ile Asp Asp Pro Asn Leu Val Val Lys Ile Gly Ser Lys
            500                 505                 510         
Tyr Tyr Asn Trp Thr Thr Ala Ala Pro Leu Leu Leu Ala Met Gln Ala
        515                 520                 525             
Phe Gln Lys Pro Leu Pro Lys Ala Thr Val Glu Ser Ile Met Arg Asp
    530                 535                 540                 
Lys Met Pro Lys Lys Gly Gly Arg Trp Trp Phe Ser Trp Arg Gly Arg
545                 550                 555                 560 
Asn Thr Thr Ile Lys Glu Glu Ser Lys Pro Glu Gln Cys Leu Ala Gly
                565                 570                 575     
Lys Ala His Ser Thr Gly Glu Gln Pro Pro Gln Leu Ser Leu Ala Thr
            580                 585                 590         
Arg Val Lys His Glu Ser Ser Ser Ser Asp Glu Glu Arg Ala Ala Ala
        595                 600                 605             
Lys Pro Ser Asn Ala Gly His Leu Pro Leu Leu Pro Asn Val Ser Tyr
    610                 615                 620                 
Lys Lys Thr Leu Arg Leu Thr Ser Glu Gln Leu Lys Ser Leu Lys Leu
625                 630                 635                 640 
Lys Asn Gly Pro Asn Asp Val Val Phe Ser Val Thr Thr Gln Tyr Gln
                645                 650                 655     
Gly Thr Cys Arg Cys Glu Gly Thr Ile Tyr Leu Trp Asn Trp Asp Asp
            660                 665                 670         
Lys Val Ile Ile Ser Asp Ile Asp Gly Thr Ile Thr Arg Ser Asp Thr
        675                 680                 685             
Leu Gly His Ile Leu Pro Thr Leu Gly Lys Asp Trp Thr His Gln Gly
    690                 695                 700                 
Ile Ala Lys Leu Tyr His Lys Val Ser Gln Asn Gly Tyr Lys Phe Leu
705                 710                 715                 720 
Tyr Cys Ser Ala Arg Ala Ile Gly Met Ala Asp Met Thr Arg Gly Tyr
                725                 730                 735     
Leu His Trp Val Asn Glu Arg Gly Thr Val Leu Pro Gln Gly Pro Leu
            740                 745                 750         
Leu Leu Ser Pro Ser Ser Leu Phe Ser Ala Leu His Arg Glu Val Ile
        755                 760                 765             
Glu Lys Lys Pro Glu Lys Phe Lys Val Gln Cys Leu Thr Asp Ile Lys
    770                 775                 780                 
Asn Leu Phe Phe Pro Asn Thr Glu Pro Phe Tyr Ala Ala Phe Gly Asn
785                 790                 795                 800 
Arg Pro Ala Asp Val Tyr Ser Tyr Lys Gln Val Gly Val Ser Leu Asn
                805                 810                 815     
Arg Ile Phe Thr Val Asn Pro Lys Gly Glu Leu Val Gln Glu His Ala
            820                 825                 830         
Lys Thr Asn Ile Ser Ser Tyr Val Arg Leu Cys Glu Val Val Asp His
        835                 840                 845             
Val Phe Pro Leu Leu Lys Arg Ser His Ser Ser Asp Phe Pro Cys Ser
    850                 855                 860                 
Asp Thr Phe Ser Asn Phe Thr Phe Trp Arg Glu Pro Leu Pro Pro Phe
865                 870                 875                 880 
Glu Asn Gln Asp Ile His Ser Ala Ser Ala
                885                 890 


<210> 25
<211> 222
<212> PRT
<213> Homo sapiens

<220> 
<223> CRIF1

<300> 
<308> UniProt Q8TAE8
<309> 2006-03-21  

<400> 25
Met Ala Ala Ser Val Arg Gln Ala Arg Ser Leu Leu Gly Val Ala Ala
 1               5                  10                  15      
Thr Leu Ala Pro Gly Ser Arg Gly Tyr Arg Ala Arg Pro Pro Pro Arg
            20                  25                  30          
Arg Arg Pro Gly Pro Arg Trp Pro Asp Pro Glu Asp Leu Leu Thr Pro
        35                  40                  45              
Arg Trp Gln Leu Gly Pro Arg Tyr Ala Ala Lys Gln Phe Ala Arg Tyr
    50                  55                  60                  
Gly Ala Ala Ser Gly Val Val Pro Gly Ser Leu Trp Pro Ser Pro Glu
65                  70                  75                  80  
Gln Leu Arg Glu Leu Glu Ala Glu Glu Arg Glu Trp Tyr Pro Ser Leu
                85                  90                  95      
Ala Thr Met Gln Glu Ser Leu Arg Val Lys Gln Leu Ala Glu Glu Gln
            100                 105                 110         
Lys Arg Arg Glu Arg Glu Gln His Ile Ala Glu Cys Met Ala Lys Met
        115                 120                 125             
Pro Gln Met Ile Val Asn Trp Gln Gln Gln Gln Arg Glu Asn Trp Glu
    130                 135                 140                 
Lys Ala Gln Ala Asp Lys Glu Arg Arg Ala Arg Leu Gln Ala Glu Ala
145                 150                 155                 160 
Gln Glu Leu Leu Gly Tyr Gln Val Asp Pro Arg Ser Ala Arg Phe Gln
                165                 170                 175     
Glu Leu Leu Gln Asp Leu Glu Lys Lys Glu Arg Lys Arg Leu Lys Glu
            180                 185                 190         
Glu Lys Gln Lys Arg Lys Lys Glu Ala Arg Ala Ala Ala Leu Ala Ala
        195                 200                 205             
Ala Val Ala Gln Asp Pro Ala Ala Ser Gly Ala Pro Ser Ser
    210                 215                 220         


<210> 26
<211> 268
<212> PRT
<213> Homo sapiens

<220> 
<223> PD1

<300> 
<308> UniProt Q15116
<309> 1997-11-01  

<400> 26
Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr
 1               5                  10                  15      
Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe
            20                  25                  30          
Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr
        35                  40                  45              
Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu
    50                  55                  60                  
Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu
65                  70                  75                  80  
Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn
                85                  90                  95      
Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala
            100                 105                 110         
Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg
        115                 120                 125             
Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly
    130                 135                 140                 
Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly Leu Leu Gly Ser
145                 150                 155                 160 
Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys Ser Arg Ala Ala
                165                 170                 175     
Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp
            180                 185                 190         
Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe
        195                 200                 205             
Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu
    210                 215                 220                 
Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser
225                 230                 235                 240 
Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro
                245                 250                 255     
Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu
            260                 265             


<210> 27
<211> 414
<212> PRT
<213> Mus musculus

<220> 
<223> Lymphocyte expansion molecule (LEM)

<300> 
<308> GenBank AKD95359.1
<309> 2015-04-26  

<400> 27
Met Arg Pro Arg Thr His Gly Ala Pro Pro Arg Asn Ile Met Ser Thr
 1               5                  10                  15      
Ile Pro Lys Trp Phe Lys Gly Ala Pro Phe Gly Val Gln Ser His Arg
            20                  25                  30          
Phe Asp Val Ser Ala Val Tyr Pro Asn Gln Lys Lys Phe Ser Thr Phe
        35                  40                  45              
Thr Glu Ala Pro Tyr Ser Arg His His Ser Val Glu Leu Ser His Ile
    50                  55                  60                  
Gly Pro Gly Thr Tyr Asn Ser Lys Asp Thr Cys Phe Ser Lys Lys Phe
65                  70                  75                  80  
Leu Glu Gln Lys Leu Gly Ser Gly Trp Ser Gln Ala His Glu Ala Thr
                85                  90                  95      
Arg Leu Thr Gln Leu Pro His Phe His Tyr Gln Ala Ile Lys Lys Glu
            100                 105                 110         
Lys Glu Gln Gln Val His Lys Arg Gly Pro Gly Ser Tyr Asn Ile Lys
        115                 120                 125             
Asp Phe Ile Thr Glu Leu Gln Lys Lys Pro Gln Ser Lys Arg Gly Leu
    130                 135                 140                 
Leu Ser Ser Gly Glu Thr Arg Phe Arg Gly Phe Ile Gly Asn Tyr Tyr
145                 150                 155                 160 
Pro Gly Pro Gly Asn Tyr Gly Glu Lys Gly Asn Pro Tyr Thr Gln Leu
                165                 170                 175     
Glu Glu Lys Ala Trp Asn Arg Ser His Ser Asp Gly Leu Met Cys Arg
            180                 185                 190         
Val Ser Asn Lys Pro Pro Leu Phe His Gln Gly Ser Gly Leu Gly Pro
        195                 200                 205             
Gly Thr Tyr Thr Ile Lys Ser Asp Leu Glu Thr Phe Val Lys Lys Ser
    210                 215                 220                 
Thr Gly Asn Arg Gly Pro Tyr Asp Ile Phe Ser Gly Glu Arg Ser Ser
225                 230                 235                 240 
Pro Leu Pro Tyr Gly His Tyr Ser Val Gln Lys Met Lys Pro Lys Glu
                245                 250                 255     
Leu Thr Asp Tyr Lys Ser Phe Leu Asp Glu Met Asn Ser Gln His Lys
            260                 265                 270         
Lys Lys Gln Gly Val Phe Ser Lys Tyr Pro Arg Asp Pro Lys His Pro
        275                 280                 285             
Thr Glu Arg Ile Phe Trp Thr Thr Leu Ser Gln Cys Pro Lys Asn Met
    290                 295                 300                 
Asp Ile Ala Gly Pro Gly Ser Trp Leu Pro His Glu Thr Glu Gln Lys
305                 310                 315                 320 
His Val Asn Arg Pro Pro Phe Leu Leu Ala Ser Lys Arg Cys Gly Leu
                325                 330                 335     
Lys Ala Tyr Gln Met Ile Leu Gly Thr Trp Asn Pro Val Gly Val Gly
            340                 345                 350         
Arg Tyr Leu Asn Thr Thr Leu Met Glu Ser Ile Asp Arg Arg Gln Arg
        355                 360                 365             
Tyr Arg Ser Leu Tyr Met Ser Glu Pro Lys Arg Tyr Leu Gln Asp Leu
    370                 375                 380                 
Thr Arg Asp Arg Leu Met Gln Lys Arg Ile Thr Pro Ile Thr Lys Gly
385                 390                 395                 400 
Lys Cys Arg Pro Thr Val Asp Tyr Asn Ser Asp Pro Thr Pro
                405                 410                 


<210> 28
<211> 1245
<212> DNA
<213> Homo sapiens

<220> 
<223> C1ORF177 1 (huLEM)

<300> 
<308> NCBI NM_152607.2
<309> 2007-11-16  

<400> 28
atgagggaaa gccaggatgc cgccggagct catggctgga accgcgtcgg ctccacggcc 60
accaagtggt tcaccggggc gcccttcggg gtgcagagcc acaggtttga catctctgct 120
gtttatccca actggaagaa gttcagcacc ttcactgagg ccccatactc cacgcgttat 180
tctacccaag tgtcccacat aggccctggg acttacagct ccaaagagac ctgcttcagc 240
aagaagaagc tgatgaagga ggtggacaca ggctgggcca aggcccagga agccacgcgg 300
ctgacccagc taccccactt ccagtaccag gccatcatga aagagaagcg gctgaaggag 360
caaaagctgg gccccggctc ctacaacctc aaagacttct tagaacagct gcgggagaaa 420
ccatgtagca cccgggggct gctcagctct ggggaggttc gcttccgagg actcactggg 480
aactactatc caggccctgg aaattatggg gagaagggta acccatacac caagctggag 540
gagaatgcct ggaaccggtc tcattccgag ggcctcatgt gcaggatgag caacaagcca 600
cacccccggc ctcatcaggg gagtggtctg ggacccggca cctacttctt caaaagcgac 660
cttgagacat atgtggcacg atccgtcggc acccgcggcc cctatgacac tttctctggt 720
gatcggagca agccactgcc ttatgggcac tactccatgc agaaaaaaaa gcccagggaa 780
ctgatgaatt tcaagagctt tgtagaagaa cttaactcac atcacaataa gaagcatggg 840
gttttttcta aacttccccg aaacccgaaa acccctacag agaggattta ctgggccaac 900
ctcagccagt gcccccgcac actggccaca tctggcccca gtttctggct tccacaagag 960
aagaaatgca aacccgtcaa ccagccccca ttcctgttga cctccaaggg gtcaggtgca 1020
aaggcctgcc agatgattat gggaagctgg aacccagtag gtgtgggccg ctacctcaac 1080
acctggctga tggagacaaa ggacaggcgg cagcgatatc gatccctatt cctgagtgga 1140
tccaaacgct acctctcaga cctggcccgg gacatgctca tgcaaatcag gctgttttgt 1200
tggaaaggcc tagaagtcat caattttggc ctctcaccaa tgtag                 1245

<210> 29
<211> 1257
<212> DNA
<213> Homo sapiens

<220> 
<223> C1ORF177 2 (huLEM)

<300> 
<308> NCBI NM_001110533.1
<309> 2016-03-27  

<400> 29
atgagggaaa gccaggatgc cgccggagct catggctgga accgcgtcgg ctccacggcc 60
accaagtggt tcaccggggc gcccttcggg gtgcagagcc acaggtttga catctctgct 120
gtttatccca actggaagaa gttcagcacc ttcactgagg ccccatactc cacgcgttat 180
tctacccaag tgtcccacat aggccctggg acttacagct ccaaagagac ctgcttcagc 240
aagaagaagc tgatgaagga ggtggacaca ggctgggcca aggcccagga agccacgcgg 300
ctgacccagc taccccactt ccagtaccag gccatcatga aagagaagcg gctgaaggag 360
caaaagctgg gccccggctc ctacaacctc aaagacttct tagaacagct gcgggagaaa 420
ccatgtagca cccgggggct gctcagctct ggggaggttc gcttccgagg actcactggg 480
aactactatc caggccctgg aaattatggg gagaagggta acccatacac caagctggag 540
gagaatgcct ggaaccggtc tcattccgag ggcctcatgt gcaggatgag caacaagcca 600
cacccccggc ctcatcaggg gagtggtctg ggacccggca cctacttctt caaaagcgac 660
cttgagacat atgtggcacg atccgtcggc acccgcggcc cctatgacac tttctctggt 720
gatcggagca agccactgcc ttatgggcac tactccatgc agaaaaaaaa gcccagggaa 780
ctgatgaatt tcaagagctt tgtagaagaa cttaactcac atcacaataa gaagcatggg 840
gttttttcta aacttccccg aaacccgaaa acccctacag agaggattta ctgggccaac 900
ctcagccagt gcccccgcac actggccaca tctggcccca gtttctggct tccacaagag 960
aagaaatgca aacccgtcaa ccagccccca ttcctgttga cctccaaggg gtcaggtgca 1020
aaggcctgcc agatgattat gggaagctgg aacccagtag gtgtgggccg ctacctcaac 1080
acctggctga tggagacaaa ggacaggcgg cagcgatatc gatccctatt cctgagtgga 1140
tccaaacgct acctctcaga cctggcccgg gacatgctca tgcaggaaag gatcacacca 1200
tttactaagg gaaagtgccc tccaactgtg gattacaatt cagatcctac tccttaa    1257

<210> 30
<211> 1593
<212> DNA
<213> Homo sapiens

<220> 
<223> Glycerol kinase (Gyk)

<300> 
<308> RefSeq NG_008178.1
<309> 2011-03-01  

<400> 30
atggcagcct caaagaaggc agttttgggg ccattggtgg gggcggtgga ccagggcacc 60
agttcgacgc gctttttggt tttcaattca aaaacagctg aactacttag tcatcatcaa 120
gtagaaataa aacaagagtt cccaagagaa ggatgggtgg aacaggaccc taaggaaatt 180
ctacattctg tctatgagtg tatagagaaa acatgtgaga aacttggaca gctcaatatt 240
gatatttcca acataaaagc tattggtgtc agcaaccaga gggaaaccac tgtagtctgg 300
gacaagataa ctggagagcc tctctacaat gctgtggtgt ggcttgatct aagaacccag 360
tctaccgttg agagtcttag taaaagaatt ccaggaaata ataactttgt caagtccaag 420
acaggccttc cacttagcac ttacttcagt gcagtgaaac ttcgttggct ccttgacaat 480
gtgagaaaag ttcaaaaggc cgttgaagaa aaacgagctc tttttgggac tattgattca 540
tggcttattt ggagtttgac aggaggagtc aatggaggtg tccactgtac agatgtaaca 600
aatgcaagta ggactatgct tttcaacatt cattctttgg aatgggataa acaactctgc 660
gaattttttg gaattccaat ggaaattctt ccaaatgtcc ggagttcttc tgagatctat 720
ggcctaatga aaatctctca tagcgtgaaa gctggggcct tggaaggtgt gccaatatct 780
gggtgtttag gggaccagtc tgctgcattg gtgggacaaa tgtgcttcca gattggacaa 840
gccaaaaata cgtatggaac aggatgtttc ttactatgta atacaggcca taagtgtgta 900
ttttctgatc atggccttct caccacagtg gcttacaaac ttggcagaga caaaccagta 960
tattatgctt tggaaggttc tgtagctata gctggtgctg ttattcgctg gctaagagac 1020
aatcttggaa ttataaagac ctcagaagaa attgaaaaac ttgctaaaga agtaggtact 1080
tcttatggct gctacttcgt cccagcattt tcggggttat atgcacctta ttgggagccc 1140
agcgcaagag ggataatctg tggactcact cagttcacca ataaatgcca tattgctttt 1200
gctgcattag aagctgtttg tttccaaact cgagagattt tggatgccat gaatcgagac 1260
tgtggaattc cactcagtca tttgcaggta gatggaggaa tgaccagcaa caaaattctt 1320
atgcagctac aagcagacat tctgtatata ccagtagtga agccctcaat gcccgaaacc 1380
actgcactgg gtgcggctat ggcggcaggg gctgcagaag gagtcggcgt atggagtctc 1440
gaacccgagg atttgtctgc cgtcacgatg gagcggtttg aacctcagat taatgcggag 1500
gaaagtgaaa ttcgttattc tacatggaag aaagctgtga tgaagtcaat gggttgggtt 1560
acaactcaat ctccagaaag tggtattcca taa                              1593

<210> 31
<211> 1467
<212> DNA
<213> Homo sapiens

<220> 
<223> DAG O-acetyltransferase 1 (DGAT1)

<300> 
<308> NCBI NM_012079.5
<309> 2013-07-19  

<400> 31
atgggcgacc gcggcagctc ccggcgccgg aggacagggt cgcggccctc gagccacggc 60
ggcggcgggc ctgcggcggc ggaagaggag gtgcgggacg ccgctgcggg ccccgacgtg 120
ggagccgcgg gggacgcgcc agccccggcc cccaacaagg acggagacgc cggcgtgggc 180
agcggccact gggagctgag gtgccatcgc ctgcaggatt ctttattcag ctctgacagt 240
ggcttcagca actaccgtgg catcctgaac tggtgtgtgg tgatgctgat cttgagcaat 300
gcccggttat ttctggagaa cctcatcaag tatggcatcc tggtggaccc catccaggtg 360
gtttctctgt tcctgaagga tccctatagc tggcccgccc catgcctggt tattgcggcc 420
aatgtctttg ctgtggctgc attccaggtt gagaagcgcc tggcggtggg tgccctgacg 480
gagcaggcgg gactgctgct gcacgtggcc aacctggcca ccattctgtg tttcccagcg 540
gctgtggtct tactggttga gtctatcact ccagtgggct ccctgctggc gctgatggcg 600
cacaccatcc tcttcctcaa gctcttctcc taccgcgacg tcaactcatg gtgccgcagg 660
gccagggcca aggctgcctc tgcagggaag aaggccagca gtgctgctgc cccgcacacc 720
gtgagctacc cggacaatct gacctaccgc gatctctact acttcctctt cgcccccacc 780
ttgtgctacg agctcaactt tccccgctct ccccgcatcc ggaagcgctt tctgctgcga 840
cggatccttg agatgctgtt cttcacccag ctccaggtgg ggctgatcca gcagtggatg 900
gtccccacca tccagaactc catgaagccc ttcaaggaca tggactactc acgcatcatc 960
gagcgcctcc tgaagctggc ggtccccaat cacctcatct ggctcatctt cttctactgg 1020
ctcttccact cctgcctgaa tgccgtggct gagctcatgc agtttggaga ccgggagttc 1080
taccgggact ggtggaactc cgagtctgtc acctacttct ggcagaactg gaacatccct 1140
gtgcacaagt ggtgcatcag acacttctac aagcccatgc ttcgacgggg cagcagcaag 1200
tggatggcca ggacaggggt gttcctggcc tcggccttct tccacgagta cctggtgagc 1260
gtccctctgc gaatgttccg cctctgggcg ttcacgggca tgatggctca gatcccactg 1320
gcctggttcg tgggccgctt tttccagggc aactatggca acgcagctgt gtggctgtcg 1380
ctcatcatcg gacagccaat agccgtcctc atgtacgtcc acgactacta cgtgctcaac 1440
tatgaggccc cagcggcaga ggcctga                                     1467

<210> 32
<211> 2487
<212> DNA
<213> Homo sapiens

<220> 
<223> Glycerol-3-phosphate acetyltransferase
      mitochondrial (GPAM)

<300> 
<308> NCBI NM_001244949.1
<309> 2011-10-01  

<400> 32
atggatgaat ctgcactgac ccttggtaca atagatgttt cttatctgcc acattcatca 60
gaatacagtg ttggtcgatg taagcacaca agtgaggaat ggggtgagtg tggctttaga 120
cccaccatct tcagatctgc aactttaaaa tggaaagaaa gcctaatgag tcggaaaagg 180
ccatttgttg gaagatgttg ttactcctgc actccccaga gctgggacaa atttttcaac 240
cccagtatcc cgtctttggg tttgcggaat gttatttata tcaatgaaac tcacacaaga 300
caccgcggat ggcttgcaag acgcctttct tacgttcttt ttattcaaga gcgagatgtg 360
cataagggca tgtttgccac caatgtgact gaaaatgtgc tgaacagcag tagagtacaa 420
gaggcaattg cagaagtggc tgctgaatta aaccctgatg gttctgccca gcagcaatca 480
aaagccgtta acaaagtgaa aaagaaagct aaaaggattc ttcaagaaat ggttgccact 540
gtctcaccgg caatgatcag actgactggg tgggtgctgc taaaactgtt caacagcttc 600
ttttggaaca ttcaaattca caaaggtcaa cttgagatgg ttaaagctgc aactgagacg 660
aatttgccgc ttctgtttct accagttcat agatcccata ttgactatct gctgctcact 720
ttcattctct tctgccataa catcaaagca ccatacattg cttcaggcaa taatctcaac 780
atcccaatct tcagtacctt gatccataag cttgggggct tcttcatacg acgaaggctc 840
gatgaaacac cagatggacg gaaagatgtt ctctatagag ctttgctcca tgggcatata 900
gttgaattac ttcgacagca gcaattcttg gagatcttcc tggaaggcac acgttctagg 960
agtggaaaaa cctcttgtgc tcgggcagga cttttgtcag ttgtggtaga tactctgtct 1020
accaatgtca tcccagacat cttgataata cctgttggaa tctcctatga tcgcattatc 1080
gaaggtcact acaatggtga acaactgggc aaacctaaga agaatgagag cctgtggagt 1140
gtagcaagag gtgttattag aatgttacga aaaaactatg gttgtgtccg agtggatttt 1200
gcacagccat tttccttaaa ggaatattta gaaagccaaa gtcagaaacc ggtgtctgct 1260
ctactttccc tggagcaagc gttgttacca gctatacttc cttcaagacc cagtgatgct 1320
gctgatgaag gtagagacac gtccattaat gagtccagaa atgcaacaga tgaatcccta 1380
cgaaggaggt tgattgcaaa tctggctgag catattctat tcactgctag caagtcctgt 1440
gccattatgt ccacacacat tgtggcttgc ctgctcctct acagacacag gcagggaatt 1500
gatctctcca cattggtcga agacttcttt gtgatgaaag aggaagtcct ggctcgtgat 1560
tttgacctgg ggttctcagg aaattcagaa gatgtagtaa tgcatgccat acagctgctg 1620
ggaaattgtg tcacaatcac ccacactagc aggaacgatg agttttttat cacccccagc 1680
acaactgtcc catcagtctt cgaactcaac ttctacagca atggggtact tcatgtcttt 1740
atcatggagg ccatcatagc ttgcagcctt tatgcagttc tgaacaagag gggactgggg 1800
ggtcccacta gcaccccacc taacctgatc agccaggagc agctggtgcg gaaggcggcc 1860
agcctgtgct accttctctc caatgaaggc accatctcac tgccttgcca gacattttac 1920
caagtctgcc atgaaacagt aggaaagttt atccagtatg gcattcttac agtggcagag 1980
cacgatgacc aggaagatat cagtcctagt cttgctgagc agcagtggga caagaagctt 2040
ccagaacctt tgtcttggag aagtgatgaa gaagatgaag acagtgactt tggggaggaa 2100
cagcgagatt gctacctgaa ggtgagccaa tccaaggagc accagcagtt tatcaccttc 2160
ttacagagac tccttgggcc tttgctggag gcctacagct ctgctgccat ctttgttcac 2220
aacttcagtg gtcctgttcc agaacctgag tatctgcaaa agttgcacaa atacctaata 2280
accagaacag aaagaaatgt tgcagtatat gctgagagtg ccacatattg tcttgtgaag 2340
aatgctgtga aaatgtttaa ggatattggg gttttcaagg agaccaaaca aaagagagtg 2400
tctgttttag aactgagcag cacttttcta cctcaatgca accgacaaaa acttctagaa 2460
tatattctga gttttgtggt gctgtag                                     2487

<210> 33
<211> 1008
<212> DNA
<213> Homo sapiens

<220> 
<223> Monoacylglycerol O-acetyltransferase (MOGAT1)

<300> 
<308> NCBI NM_058165.2
<309> 2007-06-09  

<400> 33
atgaaggtag agtttgcacc gctcaacatc cagctggcgc ggcggctgca gacggtggcc 60
gtgctgcagt gggtcctgaa atacctgctg ctcgggccga tgtccattgg aatcactgtg 120
atgctgatca tacacaacta tttgttcctt tacatccctt atttgatgtg gctttacttt 180
gactggcata ccccagagcg aggaggcagg agatccagct ggatcaaaaa ttggactctt 240
tggaaacact ttaaggacta ttttccaatt catcttatca aaactcaaga tttggatcca 300
agtcacaact atatatttgg gtttcacccc catggaataa tggcagttgg agcctttggg 360
aatttttctg taaattattc tgacttcaag gacctgtttc ctggctttac ttcatatctt 420
cacgtgctgc cactttggtt ctggtgtcct gtctttcgag aatatgtgat gagtgttggg 480
ctggtttcag tttccaagaa aagtgtgtcc tacatggtaa gcaaggaggg aggtggaaac 540
atctctgtca ttgtccttgg gggtgcaaaa gaatcactgg atgctcatcc tggaaagttc 600
actctgttca tccgccagcg gaaaggattt gttaaaattg ctttgaccca tggcgcctct 660
ctggtcccag tggtttcttt tggtgaaaat gaactgttta aacaaactga caaccctgaa 720
ggatcatgga ttagaactgt tcagaataaa ctgcagaaga tcatggggtt tgctttgccc 780
ctgtttcatg ccaggggagt ttttcagtac aattttggcc taatgaccta taggaaagcc 840
atccacactg ttgttggccg cccgatccct gttcgtcaga ctctgaaccc gacccaggag 900
cagattgagg agttacatca gacctatatg gaggaactta ggaaattgtt tgaggaacac 960
aaaggaaagt atggcattcc agagcacgag actcttgttt taaaatga              1008

<210> 34
<211> 2481
<212> DNA
<213> Homo sapiens

<220> 
<223> HIF1alpha

<300> 
<308> NCBI NM_001530.3
<309> 2008-07-26  

<400> 34
atggagggcg ccggcggcgc gaacgacaag aaaaagataa gttctgaacg tcgaaaagaa 60
aagtctcgag atgcagccag atctcggcga agtaaagaat ctgaagtttt ttatgagctt 120
gctcatcagt tgccacttcc acataatgtg agttcgcatc ttgataaggc ctctgtgatg 180
aggcttacca tcagctattt gcgtgtgagg aaacttctgg atgctggtga tttggatatt 240
gaagatgaca tgaaagcaca gatgaattgc ttttatttga aagccttgga tggttttgtt 300
atggttctca cagatgatgg tgacatgatt tacatttctg ataatgtgaa caaatacatg 360
ggattaactc agtttgaact aactggacac agtgtgtttg attttactca tccatgtgac 420
catgaggaaa tgagagaaat gcttacacac agaaatggcc ttgtgaaaaa gggtaaagaa 480
caaaacacac agcgaagctt ttttctcaga atgaagtgta ccctaactag ccgaggaaga 540
actatgaaca taaagtctgc aacatggaag gtattgcact gcacaggcca cattcacgta 600
tatgatacca acagtaacca acctcagtgt gggtataaga aaccacctat gacctgcttg 660
gtgctgattt gtgaacccat tcctcaccca tcaaatattg aaattccttt agatagcaag 720
actttcctca gtcgacacag cctggatatg aaattttctt attgtgatga aagaattacc 780
gaattgatgg gatatgagcc agaagaactt ttaggccgct caatttatga atattatcat 840
gctttggact ctgatcatct gaccaaaact catcatgata tgtttactaa aggacaagtc 900
accacaggac agtacaggat gcttgccaaa agaggtggat atgtctgggt tgaaactcaa 960
gcaactgtca tatataacac caagaattct caaccacagt gcattgtatg tgtgaattac 1020
gttgtgagtg gtattattca gcacgacttg attttctccc ttcaacaaac agaatgtgtc 1080
cttaaaccgg ttgaatcttc agatatgaaa atgactcagc tattcaccaa agttgaatca 1140
gaagatacaa gtagcctctt tgacaaactt aagaaggaac ctgatgcttt aactttgctg 1200
gccccagccg ctggagacac aatcatatct ttagattttg gcagcaacga cacagaaact 1260
gatgaccagc aacttgagga agtaccatta tataatgatg taatgctccc ctcacccaac 1320
gaaaaattac agaatataaa tttggcaatg tctccattac ccaccgctga aacgccaaag 1380
ccacttcgaa gtagtgctga ccctgcactc aatcaagaag ttgcattaaa attagaacca 1440
aatccagagt cactggaact ttcttttacc atgccccaga ttcaggatca gacacctagt 1500
ccttccgatg gaagcactag acaaagttca cctgagccta atagtcccag tgaatattgt 1560
ttttatgtgg atagtgatat ggtcaatgaa ttcaagttgg aattggtaga aaaacttttt 1620
gctgaagaca cagaagcaaa gaacccattt tctactcagg acacagattt agacttggag 1680
atgttagctc cctatatccc aatggatgat gacttccagt tacgttcctt cgatcagttg 1740
tcaccattag aaagcagttc cgcaagccct gaaagcgcaa gtcctcaaag cacagttaca 1800
gtattccagc agactcaaat acaagaacct actgctaatg ccaccactac cactgccacc 1860
actgatgaat taaaaacagt gacaaaagac cgtatggaag acattaaaat attgattgca 1920
tctccatctc ctacccacat acataaagaa actactagtg ccacatcatc accatataga 1980
gatactcaaa gtcggacagc ctcaccaaac agagcaggaa aaggagtcat agaacagaca 2040
gaaaaatctc atccaagaag ccctaacgtg ttatctgtcg ctttgagtca aagaactaca 2100
gttcctgagg aagaactaaa tccaaagata ctagctttgc agaatgctca gagaaagcga 2160
aaaatggaac atgatggttc actttttcaa gcagtaggaa ttggaacatt attacagcag 2220
ccagacgatc atgcagctac tacatcactt tcttggaaac gtgtaaaagg atgcaaatct 2280
agtgaacaga atggaatgga gcaaaagaca attattttaa taccctctga tttagcatgt 2340
agactgctgg ggcaatcaat ggatgaaagt ggattaccac agctgaccag ttatgattgt 2400
gaagttaatg ctcctataca aggcagcaga aacctactgc agggtgaaga attactcaga 2460
gctttggatc aagttaactg a                                           2481

<210> 35
<211> 1869
<212> DNA
<213> Homo sapiens

<220> 
<223> PCK1

<300> 
<308> NCBI NM_002591.3
<309> 2008-05-02  

<400> 35
atgcctcctc agctgcaaaa cggcctgaac ctctcggcca aagttgtcca gggaagcctg 60
gacagcctac cccaggcagt gagggagttt ctcgagaata acgctgagct gtgtcagcct 120
gatcacatcc acatctgtga cggctctgag gaggagaatg ggcggcttct gggccagatg 180
gaggaagagg gcatcctcag gcggctgaag aagtatgaca actgctggtt ggctctcact 240
gaccccaggg atgtggccag gatcgaaagc aagacggtta tcgtcaccca agagcaaaga 300
gacacagtgc ccatccccaa aacaggcctc agccagctcg gtcgctggat gtcagaggag 360
gattttgaga aagcgttcaa tgccaggttc ccagggtgca tgaaaggtcg caccatgtac 420
gtcatcccat tcagcatggg gccgctgggc tcgcctctgt caaagatcgg catcgagctg 480
acggattcac cctacgtggt ggccagcatg cggatcatga cgcggatggg cacgcccgtc 540
ctggaagcag tgggcgatgg ggagtttgtc aaatgcctcc attctgtggg gtgccctctg 600
cctttacaaa agcctttggt caacaactgg ccctgcaacc cggagctgac gctcatcgcc 660
cacctgcctg accgcagaga gatcatctcc tttggcagtg ggtacggcgg gaactcgctg 720
ctcgggaaga agtgctttgc tctcaggatg gccagccggc tggccaagga ggaagggtgg 780
ctggcagagc acatgctgat tctgggtata accaaccctg agggtgagaa gaagtacctg 840
gcggccgcat ttcccagcgc ctgcgggaag accaacctgg ccatgatgaa ccccagcctc 900
cccgggtgga aggttgagtg cgtcggggat gacattgcct ggatgaagtt tgacgcacaa 960
ggtcatttaa gggccatcaa cccagaaaat ggctttttcg gtgtcgctcc tgggacttca 1020
gtgaagacca accccaatgc catcaagacc atccagaaga acacaatctt taccaatgtg 1080
gccgagacca gcgacggggg cgtttactgg gaaggcattg atgagccgct agcttcaggt 1140
gtcaccatca cgtcctggaa gaataaggag tggagctcag aggatgggga accttgtgcc 1200
caccccaact cgaggttctg cacccctgcc agccagtgcc ccatcattga tgctgcctgg 1260
gagtctccgg aaggtgttcc cattgaaggc attatctttg gaggccgtag acctgctggt 1320
gtccctctag tctatgaagc tctcagctgg caacatggag tctttgtggg ggcggccatg 1380
agatcagagg ccacagcggc tgcagaacat aaaggcaaaa tcatcatgca tgaccccttt 1440
gccatgcggc ccttctttgg ctacaacttc ggcaaatacc tggcccactg gcttagcatg 1500
gcccagcacc cagcagccaa actgcccaag atcttccatg tcaactggtt ccggaaggac 1560
aaggaaggca aattcctctg gccaggcttt ggagagaact ccagggtgct ggagtggatg 1620
ttcaaccgga tcgatggaaa agccagcacc aagctcacgc ccataggcta catccccaag 1680
gaggatgccc tgaacctgaa aggcctgggg cacatcaaca tgatggagct tttcagcatc 1740
tccaaggaat tctgggagaa ggaggtggaa gacatcgaga agtatctgga ggatcaagtc 1800
aatgccgacc tcccctgtga aatcgagaga gagatccttg ccttgaagca aagaataagc 1860
cagatgtaa                                                         1869

<210> 36
<211> 852
<212> DNA
<213> Homo sapiens

<220> 
<223> AGPAT1

<300> 
<308> NCBI NM_006411.3
<309> 2010-07-27  

<400> 36
atggatttgt ggccaggggc atggatgctg ctgctgctgc tcttcctgct gctgctcttc 60
ctgctgccca ccctgtggtt ctgcagcccc agtgccaagt acttcttcaa gatggccttc 120
tacaatggct ggatcctctt cctggctgtg ctcgccatcc ctgtgtgtgc cgtgcgagga 180
cgcaacgtcg agaacatgaa gatcttgcgt ctaatgctgc tccacatcaa atacctgtac 240
gggatccgag tggaggtgcg aggggctcac cacttccctc cctcgcagcc ctatgttgtt 300
gtctccaacc accagagctc tctcgatctg cttgggatga tggaggtact gccaggccgc 360
tgtgtgccca ttgccaagcg cgagctactg tgggctggct ctgccgggct ggcctgctgg 420
ctggcaggag tcatcttcat cgaccggaag cgcacggggg atgccatcag tgtcatgtct 480
gaggtcgccc agaccctgct cacccaggac gtgagggtct gggtgtttcc tgagggaacg 540
agaaaccaca atggctccat gctgcccttc aaacgtggcg ccttccatct tgcagtgcag 600
gcccaggttc ccattgtccc catagtcatg tcctcctacc aagacttcta ctgcaagaag 660
gagcgtcgct tcacctcggg acaatgtcag gtgcgggtgc tgcccccagt gcccacggaa 720
gggctgacac cagatgacgt cccagctctg gctgacagag tccggcactc catgctcact 780
gttttccggg aaatctccac tgatggccgg ggtggtggtg actatctgaa gaagcctggg 840
ggcggtgggt ga                                                     852

<210> 37
<211> 837
<212> DNA
<213> Homo sapiens

<220> 
<223> AGPAT2 isoform alpha precursor

<300> 
<308> NCBI NM_006412.3
<309> 2005-07-05  

<400> 37
atggagctgt ggccgtgtct ggccgcggcg ctgctgttgc tgctgctgct ggtgcagctg 60
agccgcgcgg ccgagttcta cgccaaggtc gccctgtact gcgcgctgtg cttcacggtg 120
tccgccgtgg cctcgctcgt ctgcctgctg cgccacggcg gccggacggt ggagaacatg 180
agcatcatcg gctggttcgt gcgaagcttc aagtactttt acgggctccg cttcgaggtg 240
cgggacccgc gcaggctgca ggaggcccgt ccctgtgtca tcgtctccaa ccaccagagc 300
atcctggaca tgatgggcct catggaggtc cttccggagc gctgcgtgca gatcgccaag 360
cgggagctgc tcttcctggg gcccgtgggc ctcatcatgt acctcggggg cgtcttcttc 420
atcaaccggc agcgctctag cactgccatg acagtgatgg ccgacctggg cgagcgcatg 480
gtcagggaga acctcaaagt gtggatctat cccgagggta ctcgcaacga caatggggac 540
ctgctgcctt ttaagaaggg cgccttctac ctggcagtcc aggcacaggt gcccatcgtc 600
cccgtggtgt actcttcctt ctcctccttc tacaacacca agaagaagtt cttcacttca 660
ggaacagtca cagtgcaggt gctggaagcc atccccacca gcggcctcac tgcggcggac 720
gtccctgcgc tcgtggacac ctgccaccgg gccatgagga ccaccttcct ccacatctcc 780
aagacccccc aggagaacgg ggccactgcg gggtctggcg tgcagccggc ccagtag    837

<210> 38
<211> 741
<212> DNA
<213> Homo sapiens

<220> 
<223> AGPAT2 isoform beta precursor

<400> 38
atggagctgt ggccgtgtct ggccgcggcg ctgctgttgc tgctgctgct ggtgcagctg 60
agccgcgcgg ccgagttcta cgccaaggtc gccctgtact gcgcgctgtg cttcacggtg 120
tccgccgtgg cctcgctcgt ctgcctgctg cgccacggcg gccggacggt ggagaacatg 180
agcatcatcg gctggttcgt gcgaagcttc aagtactttt acgggctccg cttcgaggtg 240
cgggacccgc gcaggctgca ggaggcccgt ccctgtgtca tcgtctccaa ccaccagagc 300
atcctggaca tgatgggcct catggaggtc cttccggagc gctgcgtgca gatcgccaag 360
cgggagctgc tcttcctggg gcccgtgggc ctcatcatgt acctcggggg cgtcttcttc 420
atcaaccggc agcgctctag cactgccatg acagtgatgg ccgacctggg cgagcgcatg 480
gtcagggaga acgtgcccat cgtccccgtg gtgtactctt ccttctcctc cttctacaac 540
accaagaaga agttcttcac ttcaggaaca gtcacagtgc aggtgctgga agccatcccc 600
accagcggcc tcactgcggc ggacgtccct gcgctcgtgg acacctgcca ccgggccatg 660
aggaccacct tcctccacat ctccaagacc ccccaggaga acggggccac tgcggggtct 720
ggcgtgcagc cggcccagta g                                           741

<210> 39
<211> 1131
<212> DNA
<213> Homo sapiens

<220> 
<223> AGPAT3

<300> 
<308> NCBI NM_020132.4
<309> 2005-12-05  

<400> 39
atgggcctgc tggccttcct gaagacccag ttcgtgctgc acctgctggt cggctttgtc 60
ttcgtggtga gtggtctggt catcaacttc gtccagctgt gcacgctggc gctctggccg 120
gtcagcaagc agctctaccg ccgcctcaac tgccgcctcg cctactcact ctggagccaa 180
ctggtcatgc tgctggagtg gtggtcctgc acggagtgta cactgttcac ggaccaggcc 240
acggtagagc gctttgggaa ggagcacgca gtcatcatcc tcaaccacaa cttcgagatc 300
gacttcctct gtgggtggac catgtgtgag cgcttcggag tgctggggag ctccaaggtc 360
ctcgctaaga aggagctgct ctacgtgccc ctcatcggct ggacgtggta ctttctggag 420
attgtgttct gcaagcggaa gtgggaggag gaccgggaca ccgtggtcga agggctgagg 480
cgcctgtcgg actaccccga gtacatgtgg tttctcctgt actgcgaggg gacgcgcttc 540
acggagacca agcaccgcgt tagcatggag gtggcggctg ctaaggggct tcctgtcctc 600
aagtaccacc tgctgccgcg gaccaagggc ttcaccaccg cagtcaagtg cctccggggg 660
acagtcgcag ctgtctatga tgtaaccctg aacttcagag gaaacaagaa cccgtccctg 720
ctggggatcc tctacgggaa gaagtacgag gcggacatgt gcgtgaggag atttcctctg 780
gaagacatcc cgctggatga aaaggaagca gctcagtggc ttcataaact gtaccaggag 840
aaggacgcgc tccaggagat atataatcag aagggcatgt ttccagggga gcagtttaag 900
cctgcccgga ggccgtggac cctcctgaac ttcctgtcct gggccaccat tctcctgtct 960
cccctcttca gttttgtctt gggcgtcttt gccagcggat cacctctcct gatcctgact 1020
ttcttggggt ttgtgggagc agcttccttt ggagttcgca gactgatagg agtaactgag 1080
atagaaaaag gctccagcta cggaaaccaa gagtttaaga aaaaggaata a          1131

<210> 40
<211> 1371
<212> DNA
<213> Homo sapiens

<220> 
<223> AGPAT6 (LPA-MAG PA)

<300> 
<308> NCBI NM_178819.3
<309> 2009-02-28  

<400> 40
atgttcctgt tgctgccttt tgatagcctg attgtcaacc ttctgggcat ctccctgact 60
gtcctcttca ccctccttct cgttttcatc atagtgccag ccatttttgg agtctccttt 120
ggtatccgca aactctacat gaaaagtctg ttaaaaatct ttgcgtgggc taccttgaga 180
atggagcgag gagccaagga gaagaaccac cagctttaca agccctacac caacggaatc 240
attgcaaagg atcccacttc actagaagaa gagatcaaag agattcgtcg aagtggtagt 300
agtaaggctc tggacaacac tccagagttc gagctctctg acattttcta cttttgccgg 360
aaaggaatgg agaccattat ggatgatgag gtgacaaaga gattctcagc agaagaactg 420
gagtcctgga acctgctgag cagaaccaat tataacttcc agtacatcag ccttcggctc 480
acggtcctgt gggggttagg agtgctgatt cggtactgct ttctgctgcc gctcaggata 540
gcactggctt tcacagggat tagccttctg gtggtgggca caactgtggt gggatacttg 600
ccaaatggga ggtttaagga gttcatgagt aaacatgttc acttaatgtg ttaccggatc 660
tgcgtgcgag cgctgacagc catcatcacc taccatgaca gggaaaacag accaagaaat 720
ggtggcatct gtgtggccaa tcatacctca ccgatcgatg tgatcatctt ggccagcgat 780
ggctattatg ccatggtggg tcaagtgcac gggggactca tgggtgtgat tcagagagcc 840
atggtgaagg cctgcccaca cgtctggttt gagcgctcgg aagtgaagga tcgccacctg 900
gtggctaaga gactgactga acatgtgcaa gataaaagca agctgcctat cctcatcttc 960
ccagaaggaa cctgcatcaa taatacatcg gtgatgatgt tcaaaaaggg aagttttgaa 1020
attggagcca cagtttaccc tgttgctatc aagtatgacc ctcaatttgg cgatgccttc 1080
tggaacagca gcaaatacgg gatggtgacg tacctgctgc gaatgatgac cagctgggcc 1140
attgtctgca gcgtgtggta cctgcctccc atgactagag aggcagatga agatgctgtc 1200
cagtttgcga atagggtgaa atctgccatt gccaggcagg gaggacttgt ggacctgctg 1260
tgggatgggg gcctgaagag ggagaaggtg aaggacacgt tcaaggagga gcagcagaag 1320
ctgtacagca agatgatcgt ggggaaccac aaggacagga gccgctcctg a          1371

<210> 41
<211> 2388
<212> DNA
<213> Homo sapiens

<220> 
<223> GPAT2

<300> 
<308> NCBI NM_207328.2
<309> 2006-10-28  

<400> 41
atggccacca tgttggaagg cagatgccaa actcagccaa ggagcagccc cagtggccga 60
gaggctagcc tgtggtcgtc aggctttggg atgaagctgg aggctgtcac tccattcctg 120
gggaagtatc gcccctttgt gggtcgctgt tgccagacct gcacccccaa gagctgggag 180
tccctcttcc acagaagcat aacggaccta ggcttctgca atgtgatcct ggtgaaggag 240
gagaacacaa ggtttcgggg ctggctggtt cggaggctct gctatttcct gtggtccctg 300
gagcagcaca tccccccctg ccaggatgtc ccacagaaga tcatggaaag caccggggtg 360
cagaacctcc tctcagggag ggtcccagga ggcactgggg aaggccaggt gcctgacctt 420
gtgaagaagg aggtacagcg catcctgggt cacatccagg ccccaccccg tcccttcctg 480
gtcaggctgt tcagctgggc gctgctgagg ttcctgaact gcctgttcct gaatgtgcag 540
ctccacaagg gtcagatgaa gatggtccag aaggccgccc aggcaggctt gccgcttgtc 600
ctcctctcta ctcacaaaac cctcctggat gggatcctgc tgccctttat gctgctctcc 660
cagggcctgg gtgtgcttcg tgtggcctgg gactcccgcg cctgctcccc tgccctcaga 720
gctctgctga ggaagcttgg ggggcttttc ctgcccccag aggccagcct ctccctggac 780
agctctgagg ggctccttgc cagggctgtg gtccaggcgg tcatagagca gctgctggtt 840
agtgggcagc ccctgctcat cttcctggag gaacctcctg gggctctggg gccacggctg 900
tcagccctgg gccaggcttg ggtggggttt gtggtgcagg cagtccaggt gggcatcgtc 960
ccagatgctc tgctggtacc agtggccgtc acctatgacc tggttccgga tgcaccgtgt 1020
gacatagacc atgcctcggc ccccctgggg ctgtggacag gagctctggc tgtcctacgt 1080
agcttgtgga gccgctgggg ctgcagccac cggatctgct cccgggtgca cctagctcag 1140
cccttttccc tgcaggaata catcgtcagt gccagaagct gctggggcgg cagacagacc 1200
ctggagcagc tactgcagcc catcgtgctg ggccaatgta ctgctgtccc agacactgag 1260
aaggagcagg agtggacccc cataactggg cctctcctgg ccctcaagga agaggaccag 1320
ctcctggtca ggagactgag ctgtcatgtc ctgagtgcca gtgtagggag ctctgcggtg 1380
atgagcacgg ccattatggc aacgctgctg ctcttcaagc atcagaagct cctgggggag 1440
ttctcctggc tgacggagga gatactgttg cgtggctttg atgtaggctt ctctgggcag 1500
ctgcggagcc tgctgcagca ctcactgagc ctgctgcggg cgcacgtggc cctgctgcgc 1560
atccgtcagg gtgacttgct ggtggtgccg cagcctggcc caggcctcac acacctggca 1620
caactgagtg ctgagctgct gcccgtcttc ctgagcgagg ctgtgggcgc ctgtgcagtg 1680
cgggggctgc tggcaggcag agtgccgccc caggggccct gggagctgca gggcatattg 1740
ctgctgagcc agaatgagct gtaccgccag atcctgctgc tgatgcacct gctgccgcaa 1800
gacctgctgc tgctaaagcc ctgccagtct tcctactgct actgtcagga ggtgctggac 1860
cggctcatcc aatgcgggct cctggttgct gaggagaccc caggctcccg gccagcctgt 1920
gacacagggc gacagcgatt gagcagaaag ctgctgtgga aaccgagtgg ggactttact 1980
gatagtgaca gtgatgactt cggagaggct gacggccggt acttcaggct cagccagcag 2040
tcacactgcc cagatttctt tcttttcctc tgccgcctgc tcagcccgct gctcaaggcc 2100
tttgcacagg ctgccgcctt cctccgccag ggccagctgc ccgatactga gttgggctac 2160
acagagcagc tgttccagtt cctgcaggcc accgcccagg aagaagggat cttcgagtgt 2220
gcggacccaa agctcgccat cagtgctgtc tggaccttca gagacctagg ggttctgcag 2280
cagacgccga gccctgcagg ccccaggctc cacctgtccc ctacttttgc cagcctggac 2340
aatcaggaaa aactagaaca gttcatccgg cagttcattt gtagctag              2388

<210> 42
<211> 1005
<212> DNA
<213> Homo sapiens

<220> 
<223> MOGAT2

<300> 
<308> NCBI NM_025098.2
<309> 2003-10-07  

<400> 42
atggtagagt tcgcgccctt gtttatgccg tgggagcgca ggctgcagac acttgctgtc 60
ctacagtttg tcttctcctt cttggcactg gccgagatct gcactgtggg cttcatagcc 120
ctcctgttta caagattctg gctcctcact gtcctgtatg cggcctggtg gtatctggac 180
cgagacaagc cacggcaggg gggccggcac atccaggcca tcaggtgctg gactatatgg 240
aagtacatga aggactattt ccccatctcg ctggtcaaga ctgctgagct ggacccctct 300
cggaactaca ttgcgggctt ccacccccat ggagtcctgg cagtcggagc ctttgccaac 360
ctgtgcactg agagcacagg cttctcttcg atcttccccg gtatccgccc ccatctgatg 420
atgctgacct tgtggttccg ggcccccttc ttcagagatt acatcatgtc tgcagggttg 480
gtcacatcag aaaaggagag tgctgctcac attctgaaca ggaagggtgg cggaaacttg 540
ctgggcatca ttgtaggggg tgcccaggag gccctggatg ccaggcctgg atccttcacg 600
ctgttactgc ggaaccgaaa gggcttcgtc aggctcgccc tgacacacgg ggcacccctg 660
gtgccaatct tctccttcgg ggagaatgac ctatttgacc agattcccaa ctcttctggc 720
tcctggttac gctatatcca gaatcggttg cagaagatca tgggcatctc cctcccactc 780
tttcatggcc gtggtgtctt ccagtacagc tttggtttaa taccctaccg ccggcccatc 840
accactgtgg tggggaagcc catcgaggta cagaagacgc tgcatccctc ggaggaggag 900
gtgaaccagc tgcaccagcg ttatatcaaa gagctgtgca acctcttcga ggcccacaaa 960
cttaagttca acatccctgc tgaccagcac ttggagttct gctga                 1005

<210> 43
<211> 1167
<212> DNA
<213> Homo sapiens

<220> 
<223> DGAT2

<300> 
<308> NCBI NM_032564.4
<309> 2011-12-09  

<400> 43
atgaagaccc tcatagccgc ctactccggg gtcctgcgcg gcgagcgtca ggccgaggct 60
gaccggagcc agcgctctca cggaggacct gcgctgtcgc gcgaggggtc tgggagatgg 120
ggcactggat ccagcatcct ctccgccctc caggacctct tctctgtcac ctggctcaat 180
aggtccaagg tggaaaagca gctacaggtc atctcagtgc tccagtgggt cctgtccttc 240
cttgtactgg gagtggcctg cagtgccatc ctcatgtaca tattctgcac tgattgctgg 300
ctcatcgctg tgctctactt cacttggctg gtgtttgact ggaacacacc caagaaaggt 360
ggcaggaggt cacagtgggt ccgaaactgg gctgtgtggc gctactttcg agactacttt 420
cccatccagc tggtgaagac acacaacctg ctgaccacca ggaactatat ctttggatac 480
cacccccatg gtatcatggg cctgggtgcc ttctgcaact tcagcacaga ggccacagaa 540
gtgagcaaga agttcccagg catacggcct tacctggcta cactggcagg caacttccga 600
atgcctgtgt tgagggagta cctgatgtct ggaggtatct gccctgtcag ccgggacacc 660
atagactatt tgctttcaaa gaatgggagt ggcaatgcta tcatcatcgt ggtcgggggt 720
gcggctgagt ctctgagctc catgcctggc aagaatgcag tcaccctgcg gaaccgcaag 780
ggctttgtga aactggccct gcgtcatgga gctgacctgg ttcccatcta ctcctttgga 840
gagaatgaag tgtacaagca ggtgatcttc gaggagggct cctggggccg atgggtccag 900
aagaagttcc agaaatacat tggtttcgcc ccatgcatct tccatggtcg aggcctcttc 960
tcctccgaca cctgggggct ggtgccctac tccaagccca tcaccactgt tgtgggagag 1020
cccatcacca tccccaagct ggagcaccca acccagcaag acatcgacct gtaccacacc 1080
atgtacatgg aggccctggt gaagctcttc gacaagcaca agaccaagtt cggcctcccg 1140
gagactgagg tcctggaggt gaactga                                     1167

<210> 44
<211> 888
<212> DNA
<213> Homo sapiens

<220> 
<223> AQP9

<300> 
<308> NCBI NM_020980.3
<309> 2007-09-14  

<400> 44
atgcagcctg agggagcaga aaagggaaaa agcttcaagc agagactggt cttgaagagc 60
agcttagcga aagaaaccct ctctgagttc ttgggcacgt tcatcttgat tgtccttgga 120
tgtggctgtg ttgcccaagc tattctcagt cgaggacgtt ttggaggggt catcactatc 180
aatgttggat tttcaatggc agttgcaatg gccatttatg tggctggcgg tgtctctggt 240
ggtcacatca acccagctgt gtctttagca atgtgtctct ttggacggat gaaatggttc 300
aaattgccat tttatgtggg agcccagttc ttgggagcct ttgtgggggc tgcaaccgtc 360
tttggcattt actatgatgg acttatgtcc tttgctggtg gaaaactgct gatcgtggga 420
gaaaatgcaa cagcacacat ttttgcaaca tacccagctc cgtatctatc tctggcgaac 480
gcatttgcag atcaagtggt ggccaccatg atactcctca taatcgtctt tgccatcttt 540
gactccagaa acttgggagc ccccagaggc ctagagccca ttgccatcgg cctcctgatt 600
attgtcattg cttcctccct gggactgaac agtggctgtg ccatgaaccc agctcgagac 660
ctgagtccca gacttttcac tgccttggca ggctgggggt ttgaagtctt cagagctgga 720
aacaacttct ggtggattcc tgtagtgggc cctttggttg gtgctgtcat tggaggcctc 780
atctatgttc ttgtcattga aatccaccat ccagagcctg actcagtctt taagacagaa 840
caatctgagg acaaaccaga gaaatatgaa ctcagtgtca tcatgtag              888

<210> 45
<211> 2673
<212> DNA
<213> Homo sapiens

<220> 
<223> LPIN1 (Lipin 1)

<300> 
<308> NCBI NM_145693.2
<309> 2012-05-12  

<400> 45
atgaattacg tggggcagtt agccggccag gtgtttgtca ccgtgaagga gctctacaag 60
gggctgaatc ccgccacact ctcagggtgc attgacatca ttgtcatccg ccagcccaat 120
ggaaacctcc aatgctcccc tttccacgtc cgctttggga agatgggggt cctgcgctcc 180
cgagagaaag tggttgacat agaaatcaat ggggaatctg tggatttgca tatgaaattg 240
ggagataatg gagaagcatt ttttgttcaa gaaacagata atgatcagga agttatccct 300
atgcacctgg ccacctcccc catcctgtca gaaggagctt cgagaatgga atgccagctg 360
aaaaggggct ctgtggacag gatgagaggc ctggacccca gcacgccagc ccaagtgatc 420
gctcccagcg agacgccgtc aagcagctct gtagtaaaga agagaagaaa aaggaggaga 480
aagtcacagc tggacagcct gaagagagat gacaacatga acacatctga ggatgaggac 540
atgttcccca tcgagatgag ctcggatgag gccatggagc tgctggagag cagcagaact 600
cttcctaatg atatacctcc attccaagat gatattcctg aggaaaacct ctccctggct 660
gtgatttacc ctcagtcagc ctcataccct aattcggata gagagtggtc acccactccc 720
agtccttccg gttcccgacc ttcaacacct aaaagtgatt cagaattggt cagcaagtcc 780
acggaaagga cagggcagaa gaacccagaa atgctttggc tgtggggaga gctgccgcag 840
gctgctaagt cttcttctcc acacaagatg aaagagtcca gcccattgag cagtagaaaa 900
atttgtgata aaagtcactt tcaggccatt cacagcgaat cttcagacac ttttagtgac 960
caatcgccaa ctctggtcgg tggggcactt ttggaccaga acaagcctca gacagaaatg 1020
cagtttgtga atgaagaaga cctggagacc ttaggagcag cagcgccact cttgcccatg 1080
atcgaggagc tcaaaccccc ctctgccagt gtagtccaga cagcaaacaa gacggattct 1140
ccttccagga aaagagataa acgaagccga catcttggtg ctgacggcgt ctacttggat 1200
gacctcacag acatggatcc tgaagtggcg gccctgtatt ttcccaaaaa cggagatcct 1260
tccggactcg caaaacatgc aagcgacaac ggagcccggt cagccaacca gtccccgcag 1320
tcggtgggca gctcgggcgt ggacagtggc gtggagagca cctcggacgg gctgagggac 1380
ctcccttcca tcgccatctc cctctgcggg ggcctcagcg accaccggga gatcacgaaa 1440
gatgcattcc tggagcaagc tgtgtcatat caacagtttg tggacaaccc cgctattatc 1500
gatgacccca atctcgtggt aaagattggg agtaaatatt ataactggac aacagcagca 1560
cccctcctcc tggcaatgca ggccttccag aaacctttgc caaaggccac tgtggaatct 1620
atcatgaggg ataaaatgcc caaaaaggga ggaagatggt ggttttcatg gaggggaaga 1680
aacaccacaa tcaaggagga aagtaagcca gagcagtgct tggctggcaa ggcccatagc 1740
accggagagc aaccgccgca gctcagcttg gccaccaggg taaagcatga atcatcctcc 1800
agtgatgagg agcgcgcagc tgccaagcca tcaaacgcag gccacctccc tcttctgcct 1860
aatgtcagct acaagaagac tctccggctg acttccgagc agcttaaaag cttgaagttg 1920
aagaatggcc ccaacgacgt ggttttcagt gtcaccacgc agtaccaagg cacgtgccgc 1980
tgtgagggca ccatctatct gtggaactgg gatgataaag tcatcatttc tgatattgat 2040
gggacaatta ccagatcaga tactcttggc cacattttgc ccacccttgg gaaggattgg 2100
acccatcagg gcatcgctaa gctgtaccat aaagtgagcc agaatggata taaatttctc 2160
tactgttctg cccgtgccat cgggatggcg gacatgacgc ggggctacct gcactgggtc 2220
aacgagaggg gcacggtgct gccccagggg cccctgctgc tgagtcccag cagcctcttc 2280
tctgccctgc acagagaagt gattgaaaag aagccagaaa agtttaaagt ccagtgtttg 2340
acagacatca aaaacctgtt tttccccaac acagaaccct tttatgctgc ttttggaaac 2400
cgaccagctg atgtgtattc atacaagcaa gtaggagtgt ctttgaatag aatatttacc 2460
gtcaacccta aaggagagct ggtacaggaa catgcaaaga ccaacatctc ttcgtatgtg 2520
agactctgtg aagtagtcga ccacgttttc ccgttgctga aaagaagcca ttcttcagac 2580
tttccctgtt cggatacctt cagtaacttc accttttgga gagagccact gccacctttt 2640
gaaaaccagg acattcattc tgcctcagcg taa                              2673

<210> 46
<211> 669
<212> DNA
<213> Homo sapiens

<220> 
<223> CRIF1

<300> 
<308> NCBI NM_052850.3
<309> 2012-08-04  

<400> 46
atggcggcgt ccgtgcgaca ggcacgcagc ctactaggtg tggcggcgac cctggccccg 60
ggttcccgtg gctaccgggc gcggccgccc ccgcgccgca ggccgggacc ccggtggcca 120
gaccccgagg acctcctgac cccgcggtgg cagctgggac cgcgctacgc ggctaagcag 180
ttcgcgcgtt acggcgccgc ctccggggtg gtccccggtt cgttatggcc gtcgccggag 240
cagctgcggg agctggaggc cgaagaacgc gaatggtacc cgagcctggc gaccatgcag 300
gagtcgctgc gggtgaagca gctggccgaa gagcagaagc gtcgggagag ggagcagcac 360
atcgcagagt gcatggccaa gatgccacag atgattgtga actggcagca gcagcagcgg 420
gagaactggg agaaggccca ggctgacaag gagaggaggg cccgactgca ggctgaggcc 480
caggagctcc tgggctacca ggtggaccca aggagtgccc gcttccagga gctgctccag 540
gacctagaga agaaggagcg caagcgcctc aaggaggaaa aacagaaacg gaagaaggag 600
gcgcgagctg ctgcattggc tgcagctgtg gctcaagacc cagcagcctc tggggcaccc 660
agctcctga                                                         669

<210> 47
<211> 867
<212> DNA
<213> Homo sapiens

<220> 
<223> PD1

<300> 
<308> GenBank KJ865859.1
<309> 2015-09-22  

<400> 47
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg 60
ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc 120
ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg 180
gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc 240
gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg 300
cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc 360
tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca 420
gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc 480
aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc 540
ctggtgctgc tagtctgggt cctggccgtc atctgctccc gggccgcacg agggacaata 600
ggagccaggc gcaccggcca gcccctgaag gaggacccct cagccgtgcc tgtgttctct 660
gtggactatg gggagctgga tttccagtgg cgagagaaga ccccggagcc ccccgtgccc 720
tgtgtccctg agcagacgga gtatgccacc attgtctttc ctagcggaat gggcacctca 780
tcccccgccc gcaggggctc agctgacggc cctcggagtg cccagccact gaggcctgag 840
gatggacact gctcttggcc cctctga                                     867

<210> 48
<211> 1245
<212> DNA
<213> Mus musculus

<220> 
<223> Lymphocyte expansion molecule (LEM)

<300> 
<308> GenBank KP939367.1
<309> 2015-04-26  

<400> 48
atgagacctc gcacccacgg cgcccccccg cgcaacatca tgtccaccat ccccaagtgg 60
ttcaaagggg cgccctttgg ggtgcagagc cacaggtttg atgtctccgc tgtctatccc 120
aaccagaaga aattcagcac cttcacagag gccccatact ccagacatca ttcggtggaa 180
ctgtcccaca taggacctgg gacctataac tccaaggata cctgcttcag caagaagttc 240
ctggaacaga agttgggctc aggatggtcc caggcccacg aagccactcg gctgacccag 300
ctaccccact tccactacca ggccatcaag aaggaaaaag agcagcaggt gcacaagcgt 360
ggccctggct cctacaacat caaagacttc ataactgagc tgcagaagaa accacagagc 420
aaacgggggc tgctcagctc tggggagaca cgtttccgag gttttattgg gaattattat 480
cctggccctg gaaattatgg ggagaagggg aacccgtaca cacagctgga ggagaaggcc 540
tggaaccgct cacattctga cggcctgatg tgtagagtgt ctaacaagcc acccttgttt 600
catcagggca gtggcctggg acctggtacc tacaccatca aaagcgatct tgagaccttt 660
gtgaaaaagt ccactggtaa tcgtggcccc tatgacattt tctctggtga acggagcagt 720
cctttgccct atggacatta ctctgtgcag aaaatgaagc ccaaggaact gacagattac 780
aagagctttc tggacgaaat gaactcacaa cacaagaaga aacaaggggt tttctcgaaa 840
tatccccgag atccgaaaca ccccacagag agaattttct ggacaaccct tagtcagtgc 900
cccaaaaata tggatatagc tggccctggt tcttggcttc ctcatgagac ggaacagaaa 960
catgtcaacc ggccaccgtt cctcctggcc tccaaacggt gcggcctaaa ggcctaccag 1020
atgattttgg gaacctggaa cccagttggc gtaggccgct atctcaacac cacgctgatg 1080
gagtccatag accgaaggca gcgataccgt tctctgtaca tgagtgagcc caagcgatac 1140
ctgcaagacc taacccgaga cagactcatg cagaaacgga ttacacctat tacgaagggc 1200
aagtgccgtc caactgtgga ctacaattca gatcctactc cttaa                 1245

<210> 49
<211> 12
<212> PRT
<213> Homo sapiens

<220> 
<223> Spacer (IgG4hinge)

<400> 49
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro
 1               5                  10          


<210> 50
<211> 36
<212> DNA
<213> Homo sapiens

<220> 
<223> Spacer (IgG4hinge)

<400> 50
gaatctaagt acggaccgcc ctgcccccct tgccct                           36

<210> 51
<211> 119
<212> PRT
<213> Homo sapiens

<220> 
<223> Hinge-CH3 spacer

<400> 51
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gln Pro Arg
 1               5                  10                  15      
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys
            20                  25                  30          
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
        35                  40                  45              
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
    50                  55                  60                  
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
65                  70                  75                  80  
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser
                85                  90                  95      
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
            100                 105                 110         
Leu Ser Leu Ser Leu Gly Lys
        115                 


<210> 52
<211> 229
<212> PRT
<213> Homo sapiens

<220> 
<223> Hinge-CH2-CH3 spacer

<400> 52
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe
 1               5                  10                  15      
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
            20                  25                  30          
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
        35                  40                  45              
Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val
    50                  55                  60                  
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser
65                  70                  75                  80  
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
                85                  90                  95      
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser
            100                 105                 110         
Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
        115                 120                 125             
Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln
    130                 135                 140                 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
145                 150                 155                 160 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
                165                 170                 175     
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu
            180                 185                 190         
Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser
        195                 200                 205             
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
    210                 215                 220                 
Leu Ser Leu Gly Lys
225                 


<210> 53
<211> 282
<212> PRT
<213> Homo sapiens

<220> 
<223> IgD-hinge-Fc

<400> 53
Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala
 1               5                  10                  15      
Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala
            20                  25                  30          
Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys
        35                  40                  45              
Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro
    50                  55                  60                  
Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val Gln
65                  70                  75                  80  
Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val Gly
                85                  90                  95      
Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys Val
            100                 105                 110         
Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn Gly
        115                 120                 125             
Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp Asn
    130                 135                 140                 
Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro Pro
145                 150                 155                 160 
Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val Lys
                165                 170                 175     
Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala Ser
            180                 185                 190         
Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu Leu
        195                 200                 205             
Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala Pro
    210                 215                 220                 
Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala Trp Ser
225                 230                 235                 240 
Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr Thr
                245                 250                 255     
Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser Arg
            260                 265                 270         
Ser Leu Glu Val Ser Tyr Val Thr Asp His
        275                 280         


<210> 54
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> T2A

<400> 54
Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp
 1               5                  10                  15      
Val Glu Glu Asn Pro Gly Pro Arg
            20                  


<210> 55
<211> 357
<212> PRT
<213> Artificial Sequence

<220> 
<223> tEGFR

<400> 55
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly
            20                  25                  30          
Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe
        35                  40                  45              
Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala
    50                  55                  60                  
Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu
65                  70                  75                  80  
Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile
                85                  90                  95      
Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu
            100                 105                 110         
Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala
        115                 120                 125             
Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu
    130                 135                 140                 
Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr
145                 150                 155                 160 
Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys
                165                 170                 175     
Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly
            180                 185                 190         
Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu
        195                 200                 205             
Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys
    210                 215                 220                 
Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu
225                 230                 235                 240 
Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met
                245                 250                 255     
Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala
            260                 265                 270         
His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val
        275                 280                 285             
Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His
    290                 295                 300                 
Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro
305                 310                 315                 320 
Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala
                325                 330                 335     
Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly
            340                 345                 350         
Ile Gly Leu Phe Met
        355         


<210> 56
<211> 27
<212> PRT
<213> Homo sapiens

<220> 
<223> CD28

<300> 
<308> UniProt P10747
<309> 1989-07-01  

<400> 56
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu
 1               5                  10                  15      
Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
            20                  25          


<210> 57
<211> 66
<212> PRT
<213> Homo sapiens

<220> 
<223> CD28

<300> 
<308> UniProt P10747
<309> 1989-07-01  

<400> 57
Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
 1               5                  10                  15      
Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
            20                  25                  30          
Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
        35                  40                  45              
Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
    50                  55                  60                  
Trp Val
65      


<210> 58
<211> 41
<212> PRT
<213> Homo sapiens

<220> 
<223> CD28

<300> 
<308> UniProt P10747
<309> 1989-07-01  

<400> 58
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr
 1               5                  10                  15      
Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
            20                  25                  30          
Pro Arg Asp Phe Ala Ala Tyr Arg Ser
        35                  40      


<210> 59
<211> 41
<212> PRT
<213> Homo sapiens

<220> 
<223> CD28

<400> 59
Arg Ser Lys Arg Ser Arg Gly Gly His Ser Asp Tyr Met Asn Met Thr
 1               5                  10                  15      
Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
            20                  25                  30          
Pro Arg Asp Phe Ala Ala Tyr Arg Ser
        35                  40      


<210> 60
<211> 42
<212> PRT
<213> Homo sapiens

<220> 
<223> 4-1BB

<300> 
<308> UniProt Q07011.1
<309> 1995-02-01  

<400> 60
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met
 1               5                  10                  15      
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe
            20                  25                  30          
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu
        35                  40          


<210> 61
<211> 112
<212> PRT
<213> Homo sapiens

<220> 
<223> CD3 zeta

<400> 61
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly
 1               5                  10                  15      
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr
            20                  25                  30          
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys
        35                  40                  45              
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys
    50                  55                  60                  
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg
65                  70                  75                  80  
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala
                85                  90                  95      
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
            100                 105                 110         


<210> 62
<211> 112
<212> PRT
<213> Homo sapiens

<220> 
<223> CD3 zeta

<400> 62
Arg Val Lys Phe Ser Arg Ser Ala Glu Pro Pro Ala Tyr Gln Gln Gly
 1               5                  10                  15      
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr
            20                  25                  30          
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys
        35                  40                  45              
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys
    50                  55                  60                  
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg
65                  70                  75                  80  
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala
                85                  90                  95      
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
            100                 105                 110         


<210> 63
<211> 112
<212> PRT
<213> Homo sapiens

<220> 
<223> CD3 zeta

<400> 63
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly
 1               5                  10                  15      
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr
            20                  25                  30          
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys
        35                  40                  45              
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys
    50                  55                  60                  
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg
65                  70                  75                  80  
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala
                85                  90                  95      
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
            100                 105                 110         


<210> 64
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> T2A

<400> 64
Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro
 1               5                  10                  15      
Gly Pro
        


<210> 65
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> P2A

<400> 65
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val
 1               5                  10                  15      
Glu Glu Asn Pro Gly Pro
            20          


<210> 66
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> P2A

<400> 66
Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn
 1               5                  10                  15      
Pro Gly Pro
            


<210> 67
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> E2A

<400> 67
Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser
 1               5                  10                  15      
Asn Pro Gly Pro
            20  


<210> 68
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> F2A

<400> 68
Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val
 1               5                  10                  15      
Glu Ser Asn Pro Gly Pro
            20          


<210> 69
<211> 418
<212> PRT
<213> Homo sapiens

<220> 
<223> Lymphocyte expansion molecule (LEM) isoform 2

<300> 
<308> NCBI NP_001104003.1
<309> 2016-03-27  

<400> 69
Met Arg Glu Ser Gln Asp Ala Ala Gly Ala His Gly Trp Asn Arg Val
 1               5                  10                  15      
Gly Ser Thr Ala Thr Lys Trp Phe Thr Gly Ala Pro Phe Gly Val Gln
            20                  25                  30          
Ser His Arg Phe Asp Ile Ser Ala Val Tyr Pro Asn Trp Lys Lys Phe
        35                  40                  45              
Ser Thr Phe Thr Glu Ala Pro Tyr Ser Thr Arg Tyr Ser Thr Gln Val
    50                  55                  60                  
Ser His Ile Gly Pro Gly Thr Tyr Ser Ser Lys Glu Thr Cys Phe Ser
65                  70                  75                  80  
Lys Lys Lys Leu Met Lys Glu Val Asp Thr Gly Trp Ala Lys Ala Gln
                85                  90                  95      
Glu Ala Thr Arg Leu Thr Gln Leu Pro His Phe Gln Tyr Gln Ala Ile
            100                 105                 110         
Met Lys Glu Lys Arg Leu Lys Glu Gln Lys Leu Gly Pro Gly Ser Tyr
        115                 120                 125             
Asn Leu Lys Asp Phe Leu Glu Gln Leu Arg Glu Lys Pro Cys Ser Thr
    130                 135                 140                 
Arg Gly Leu Leu Ser Ser Gly Glu Val Arg Phe Arg Gly Leu Thr Gly
145                 150                 155                 160 
Asn Tyr Tyr Pro Gly Pro Gly Asn Tyr Gly Glu Lys Gly Asn Pro Tyr
                165                 170                 175     
Thr Lys Leu Glu Glu Asn Ala Trp Asn Arg Ser His Ser Glu Gly Leu
            180                 185                 190         
Met Cys Arg Met Ser Asn Lys Pro His Pro Arg Pro His Gln Gly Ser
        195                 200                 205             
Gly Leu Gly Pro Gly Thr Tyr Phe Phe Lys Ser Asp Leu Glu Thr Tyr
    210                 215                 220                 
Val Ala Arg Ser Val Gly Thr Arg Gly Pro Tyr Asp Thr Phe Ser Gly
225                 230                 235                 240 
Asp Arg Ser Lys Pro Leu Pro Tyr Gly His Tyr Ser Met Gln Lys Lys
                245                 250                 255     
Lys Pro Arg Glu Leu Met Asn Phe Lys Ser Phe Val Glu Glu Leu Asn
            260                 265                 270         
Ser His His Asn Lys Lys His Gly Val Phe Ser Lys Leu Pro Arg Asn
        275                 280                 285             
Pro Lys Thr Pro Thr Glu Arg Ile Tyr Trp Ala Asn Leu Ser Gln Cys
    290                 295                 300                 
Pro Arg Thr Leu Ala Thr Ser Gly Pro Ser Phe Trp Leu Pro Gln Glu
305                 310                 315                 320 
Lys Lys Cys Lys Pro Val Asn Gln Pro Pro Phe Leu Leu Thr Ser Lys
                325                 330                 335     
Gly Ser Gly Ala Lys Ala Cys Gln Met Ile Met Gly Ser Trp Asn Pro
            340                 345                 350         
Val Gly Val Gly Arg Tyr Leu Asn Thr Trp Leu Met Glu Thr Lys Asp
        355                 360                 365             
Arg Arg Gln Arg Tyr Arg Ser Leu Phe Leu Ser Gly Ser Lys Arg Tyr
    370                 375                 380                 
Leu Ser Asp Leu Ala Arg Asp Met Leu Met Gln Glu Arg Ile Thr Pro
385                 390                 395                 400 
Phe Thr Lys Gly Lys Cys Pro Pro Thr Val Asp Tyr Asn Ser Asp Pro
                405                 410                 415     
Thr Pro
        


<210> 70
<211> 1254
<212> DNA
<213> Homo sapiens

<220> 
<223> Lymphocyte expansion molecule (LEM) isoform 2

<300> 
<308> NCBI NM_001110533.1
<309> 2016-03-27  

<400> 70
atgagggaaa gccaggatgc cgccggagct catggctgga accgcgtcgg ctccacggcc 60
accaagtggt tcaccggggc gcccttcggg gtgcagagcc acaggtttga catctctgct 120
gtttatccca actggaagaa gttcagcacc ttcactgagg ccccatactc cacgcgttat 180
tctacccaag tgtcccacat aggccctggg acttacagct ccaaagagac ctgcttcagc 240
aagaagaagc tgatgaagga ggtggacaca ggctgggcca aggcccagga agccacgcgg 300
ctgacccagc taccccactt ccagtaccag gccatcatga aagagaagcg gctgaaggag 360
caaaagctgg gccccggctc ctacaacctc aaagacttct tagaacagct gcgggagaaa 420
ccatgtagca cccgggggct gctcagctct ggggaggttc gcttccgagg actcactggg 480
aactactatc caggccctgg aaattatggg gagaagggta acccatacac caagctggag 540
gagaatgcct ggaaccggtc tcattccgag ggcctcatgt gcaggatgag caacaagcca 600
cacccccggc ctcatcaggg gagtggtctg ggacccggca cctacttctt caaaagcgac 660
cttgagacat atgtggcacg atccgtcggc acccgcggcc cctatgacac tttctctggt 720
gatcggagca agccactgcc ttatgggcac tactccatgc agaaaaaaaa gcccagggaa 780
ctgatgaatt tcaagagctt tgtagaagaa cttaactcac atcacaataa gaagcatggg 840
gttttttcta aacttccccg aaacccgaaa acccctacag agaggattta ctgggccaac 900
ctcagccagt gcccccgcac actggccaca tctggcccca gtttctggct tccacaagag 960
aagaaatgca aacccgtcaa ccagccccca ttcctgttga cctccaaggg gtcaggtgca 1020
aaggcctgcc agatgattat gggaagctgg aacccagtag gtgtgggccg ctacctcaac 1080
acctggctga tggagacaaa ggacaggcgg cagcgatatc gatccctatt cctgagtgga 1140
tccaaacgct acctctcaga cctggcccgg gacatgctca tgcaggaaag gatcacacca 1200
tttactaagg gaaagtgccc tccaactgtg gattacaatt cagatcctac tcct       1254

<210> 71
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> T2A

<400> 71
ctcgagggcg gcggagaggg cagaggaagt cttctaacat gcggtgacgt ggaggagaat 60
cccggcccta gg                                                     72

<210> 72
<211> 22
<212> PRT
<213> Homo sapiens

<220> 
<223> GMCSFR alpha chain signal sequence

<300> 
<308> UniProt P15509
<309> 1990-04-01  

<400> 72
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro
            20          


<210> 73
<211> 66
<212> DNA
<213> Homo sapiens

<220> 
<223> GMCSFR alpha chain signal  sequence

<400> 73
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg 60
atccca                                                            66

<210> 74
<211> 363
<212> DNA
<213> Artificial Sequence

<220> 
<223> Modified Her2t

<400> 74
tgccaccctg agtgtcagcc ccagaatggc tcagtgacct gttttggacc ggaggctgac 60
cagtgtgtgg cctgtgccca ctataaggac cctcccttct gcgtggcccg ctgccccagc 120
ggtgtgaaac ctgacctctc ctacatgccc atctggaagt ttccagatga ggagggcgca 180
tgccagcctt gccccatcaa ctgcacccac tcctgtgtgg acctggatga caagggctgc 240
cccgccgagc agagagccag ccctctgacg ggtggaggaa gcggaggtgg cagctccatc 300
atctctgcgg tggttggcat tctgctggtc gtggtcttgg gggtggtctt tgggatcctc 360
atc                                                               363

<210> 75
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> Modified Her2t

<400> 75
Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Phe Gly
 1               5                  10                  15      
Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro
            20                  25                  30          
Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr
        35                  40                  45              
Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys
    50                  55                  60                  
Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys Gly Cys
65                  70                  75                  80  
Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Gly Gly Gly Ser Gly Gly
                85                  90                  95      
Gly Ser Ser Ile Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val
            100                 105                 110         
Leu Gly Val Val Phe Gly Ile Leu Ile
        115                 120     


<210> 76
<211> 1464
<212> DNA
<213> Artificial Sequence

<220> 
<223> DAG O-acetyltransferase 1 (DGAT1)

<400> 76
atgggcgatc gcggcagctc ccggagaagg cgcaccggca gccggccctc tagccacggc 60
ggcggcggcc ctgctgccgc cgaggaggag gtgcgcgacg ccgccgccgg ccctgatgtg 120
ggagcagcag gcgacgcacc agcacctgcc ccaaacaagg acggcgatgc aggagtggga 180
agcggacact gggagctgag atgccacagg ctgcaggatt ccctgttctc ctctgacagc 240
ggcttttcca actacagagg catcctgaat tggtgcgtgg tcatgctgat cctgtccaac 300
gccaggctgt tcctggagaa tctgatcaag tacggcatcc tggtggatcc tatccaggtg 360
gtgagcctgt ttctgaagga cccatattcc tggccagcac cttgcctggt catcgcagca 420
aacgtgttcg cagtggcagc ctttcaggtg gagaagcggc tggccgtggg cgccctgacc 480
gagcaggcag gcctgctgct gcacgtggcc aatctggcca caatcctgtg cttcccagca 540
gcagtggtgc tgctggtgga gtctatcacc cctgtgggaa gcctgctggc cctgatggca 600
cacacaatcc tgttcctgaa gctgttttcc tacagagacg tgaattcttg gtgtaggaga 660
gcaagggcaa aggcagcctc tgccggcaag aaggccagca gcgccgccgc ccctcacacc 720
gtgagctacc cagataacct gacatataga gacctgtact atttcctgtt tgcccccacc 780
ctgtgctatg agctgaattt cccaaggtcc cccaggatcc gcaagcggtt tctgctgagg 840
cgcatcctgg agatgctgtt ctttacccag ctgcaagtgg gcctgatcca gcagtggatg 900
gtgccaacaa tccagaactc catgaagccc ttcaaggaca tggattactc tagaatcatc 960
gagaggctgc tgaagctggc cgtgcccaac cacctgatct ggctgatctt cttttattgg 1020
ctgtttcact cttgcctgaa tgccgtggcc gagctgatgc agttcggcga tcgcgagttt 1080
taccgggact ggtggaattc cgagtctgtg acatatttct ggcagaactg gaatatccca 1140
gtgcacaagt ggtgtatccg ccacttttac aagcccatgc tgcggagagg ctctagcaag 1200
tggatggcca gaaccggcgt gttcctggcc tctgccttct ttcacgagta tctggtgagc 1260
gtgcctctgc gcatgttccg gctgtgggcc tttacaggca tgatggccca gatcccactg 1320
gcctggtttg tgggccggtt ctttcagggc aactacggca atgccgccgt gtggctgagc 1380
ctgatcatcg gccagcccat cgccgtgctg atgtacgtgc acgattacta tgtgctgaac 1440
tatgaggccc ctgccgccga ggcc                                        1464

<210> 77
<211> 1677
<212> DNA
<213> Artificial Sequence

<220> 
<223> Glycerol kinase (Gyk)

<400> 77
atggcagcca gcaagaaggc cgtgctgggc ccactggtgg gagcagtgga ccagggcacc 60
agctccacaa ggttcctggt gtttaatagc aagaccgcag agctgctgtc ccaccaccag 120
gtggagatca agcaggagtt tccaagggag ggatgggtgg agcaggaccc aaaggagatc 180
ctgcactccg tgtacgagtg catcgagaag acctgtgaga agctgggcca gctgaatatc 240
gacatcagca acatcaaggc catcggcgtg tccaatcagc gggagaccac agtggtgtgg 300
gacaagatca caggcgagcc cctgtataac gccgtggtgt ggctggatct gaggacccag 360
agcacagtgg agtccctgtc taagcgcatc cctggcaaca ataactttgt gaagtccaag 420
accggcctgc cactgtccac atatttctct gccgtgaagc tgaggtggct gctggacaat 480
gtgcgcaagg tgcagaaggc cgtggaggag aagagggccc tgtttggcac catcgattct 540
tggctgatct ggagcctgac aggaggagtg aacggaggcg tgcactgcac cgacgtgaca 600
aatgcctctc ggaccatgct gttcaacatc cacagcctgg agtgggataa gcagctgtgc 660
gagttctttg gcatccctat ggagatcctg ccaaacgtga gatctagctc cgagatctat 720
ggcctgatga agatcagcca ctccgtgaag gcaggcgccc tggagggagt gcctatctct 780
ggatgcctgg gcgaccagag cgccgccctg gtgggacaga tgtgcttcca gatcggccag 840
gccaagaata cctacggcac aggctgcttt ctgctgtgca acaccggcca caagtgcgtg 900
ttcagcgacc acggcctgct gaccacagtg gcctataagc tgggcaggga taagcccgtg 960
tactatgcac tggagggatc tgtggcaatc gcaggagccg tgatcaggtg gctgagagat 1020
aatctgggca tcatcaagac cagcgaggag atcgagaagc tggccaagga agtgggcaca 1080
tcctacggct gttatttcgt gcctgccttt tctggcctgt acgcaccata ttgggagcca 1140
agcgccaggg gaatcatctg cggcctgacc cagttcacaa acaagtgtca catcgccttt 1200
gccgccctgg aggccgtgtg cttccagacc cgggagatcc tggacgccat gaatagagat 1260
tgtggcatcc ctctgtccca cctgcaggtg gacggaggca tgacatctaa caagatcctg 1320
atgcagctgc aggccgacat cctgtatatc ccagtggtga agccctccat gcctgagacc 1380
acagccctgg gagcagcaat ggcagcagga gcagccgagg gcgtgggcgt gtggtccctg 1440
gagccagagg acctgtctgc cgtgaccatg gagcggtttg agcctcagat caatgccgag 1500
gagtccgaga tcagatactc tacatggaag aaggccgtga tgaagtccat gggctgggtg 1560
accacacagt ctcccgagag cggcgatcct agcatcttct gctccctgcc actgggcttc 1620
tttatcgtgt ctagcatggt catgctgatc ggcgcccggt atatctctgg catcccc    1677

<210> 78
<211> 2484
<212> DNA
<213> Artificial Sequence

<220> 
<223> Glycerol-3-phosphate acetyltransferase
      mitochondrial (GPAM)

<400> 78
atggacgagt ccgccctgac actgggcacc atcgacgtga gctacctgcc acacagctcc 60
gagtattctg tgggcaggtg caagcacaca agcgaggagt ggggagagtg tggcttccgg 120
ccaacaatct ttagatccgc caccctgaag tggaaggaga gcctgatgtc ccggaagaga 180
ccattcgtgg gccggtgctg ttactcctgc accccccagt cttgggacaa gttctttaac 240
ccttctatcc caagcctggg cctgagaaac gtgatctaca tcaatgagac ccacacaagg 300
cacaggggat ggctggcccg gagactgagc tatgtgctgt tcatccagga gagggacgtg 360
cacaagggca tgtttgccac aaatgtgacc gagaacgtgc tgaattctag ccgcgtgcag 420
gaggcaatcg cagaggtggc agcagagctg aaccctgatg gaagcgccca gcagcagtcc 480
aaggcagtga ataaggtgaa gaagaaggcc aagcggatcc tgcaggagat ggtggccaca 540
gtgtccccag ccatgatcag actgaccggc tgggtgctgc tgaagctgtt caactctttc 600
ttttggaata tccagatcca caagggccag ctggagatgg tgaaggccgc caccgagaca 660
aacctgccac tgctgtttct gcccgtgcac cgcagccaca tcgattacct gctgctgacc 720
ttcatcctgt tttgtcacaa catcaaggcc ccttatatcg ccagcggcaa caatctgaat 780
atcccaatct tctccacact gatccacaag ctgggcggct tctttatcag gcgccggctg 840
gatgagaccc ctgacggcag gaaggatgtg ctgtaccgcg ccctgctgca cggacacatc 900
gtggagctgc tgaggcagca gcagttcctg gagatctttc tggagggcac acggtctaga 960
agcggcaaga cctcctgcgc aagggcagga ctgctgtccg tggtggtgga cacactgtct 1020
accaacgtga tccccgacat cctgatcatc cctgtgggca tctcttacga ccggatcatc 1080
gagggccact ataacggcga gcagctgggc aagcccaaga agaatgagtc cctgtggtct 1140
gtggccaggg gcgtgatccg gatgctgaga aagaattacg gatgcgtgcg ggtggatttc 1200
gcacagcctt tttccctgaa ggagtatctg gagtcccagt ctcagaagcc cgtgagcgcc 1260
ctgctgtccc tggagcaggc cctgctgcct gcaatcctgc caagcagacc ttccgatgca 1320
gcagacgagg gaagggacac atctatcaac gagagcagaa atgccaccga tgagagcctg 1380
agaaggcgcc tgatcgccaa cctggccgag cacatcctgt tcacagccag caagtcctgc 1440
gccatcatga gcacccacat cgtggcctgt ctgctgctgt accggcacag gcagggaatc 1500
gacctgtcca cactggtgga ggatttcttt gtgatgaagg aggaggtgct ggccagggac 1560
ttcgatctgg gcttttctgg caatagcgag gacgtggtca tgcacgccat ccagctgctg 1620
ggcaactgcg tgaccatcac acacacctcc cgcaatgatg agttctttat caccccttct 1680
accacagtgc caagcgtgtt cgagctgaac ttttactcta atggcgtgct gcacgtgttt 1740
atcatggagg ccatcatcgc ctgcagcctg tatgccgtgc tgaacaagag gggactgggc 1800
ggcccaacaa gcaccccccc taatctgatc tcccaggagc agctggtgag aaaggccgcc 1860
tccctgtgct atctgctgtc taacgagggc acaatcagcc tgccctgcca gaccttctac 1920
caggtgtgcc acgagacagt gggcaagttt atccagtatg gcatcctgac cgtggccgag 1980
cacgacgatc aggaggacat ctctcctagc ctggccgagc agcagtggga taagaagctg 2040
ccagagcccc tgtcctggag gtctgacgag gaggacgagg atagcgactt cggcgaggag 2100
cagcgcgatt gttacctgaa ggtgtcccag tctaaggagc accagcagtt catcaccttt 2160
ctgcagcggc tgctgggccc actgctggag gcctattcct ctgccgccat cttcgtgcac 2220
aacttttccg gccctgtgcc agagccagag tacctgcaga agctgcacaa gtatctgatc 2280
acaaggaccg agaggaacgt ggccgtgtac gcagagagcg ccacctattg cctggtgaag 2340
aatgccgtga agatgttcaa ggacatcggc gtgtttaagg agacaaagca gaagcgggtg 2400
tctgtgctgg agctgagctc caccttcctg ccccagtgta atagacagaa gctgctggag 2460
tacatcctga gctttgtggt gctg                                        2484

<210> 79
<211> 2478
<212> DNA
<213> Artificial Sequence

<220> 
<223> HIF1alpha

<400> 79
atggagggcg ccggcggcgc caacgataag aagaagatca gctccgagcg gagaaaggag 60
aagagcaggg acgcagcacg ctctaggcgc agcaaggagt ccgaggtgtt ctacgagctg 120
gcccaccagc tgccactgcc acacaacgtg tctagccacc tggataaggc cagcgtgatg 180
cggctgacca tctcctatct gcgggtgaga aagctgctgg acgccggcga tctggacatc 240
gaggacgata tgaaggccca gatgaattgc ttctacctga aggccctgga cggctttgtg 300
atggtgctga ccgacgatgg cgacatgatc tacatctccg ataacgtgaa taagtatatg 360
ggcctgaccc agtttgagct gacaggccac agcgtgttcg actttaccca cccctgcgat 420
cacgaggaga tgagggagat gctgacacac cgcaacggcc tggtgaagaa gggcaaggag 480
cagaataccc agcggtcttt ctttctgaga atgaagtgta ccctgacaag caggggccgc 540
accatgaaca tcaagtccgc cacatggaag gtgctgcact gcaccggcca catccacgtg 600
tacgatacca actccaatca gccacagtgt ggctataaga agccccctat gacatgcctg 660
gtgctgatct gtgagcctat cccacacccc tctaatatcg agatccccct ggacagcaag 720
accttcctgt ctcggcacag cctggacatg aagtttagct actgcgatga gagaatcaca 780
gagctgatgg gctatgagcc tgaggagctg ctgggcagat ctatctacga gtactatcac 840
gccctggata gcgaccacct gaccaagaca caccacgaca tgttcaccaa gggccaggtg 900
accacaggcc agtacaggat gctggccaag aggggaggat acgtgtgggt ggagacccag 960
gccacagtga tctataacac caagaatagc cagccccagt gcatcgtgtg cgtgaactac 1020
gtggtgtccg gcatcatcca gcacgatctg atcttttctc tgcagcagac cgagtgcgtg 1080
ctgaagcctg tggagtcctc tgacatgaag atgacccagc tgttcacaaa ggtggagtcc 1140
gaggacacaa gctccctgtt tgataagctg aagaaggagc cagacgcact gaccctgctg 1200
gccccagcag caggcgatac aatcatctct ctggacttcg gcagcaatga taccgagaca 1260
gacgatcagc agctggagga ggtgcctctg tataacgatg tgatgctgcc ttctccaaat 1320
gagaagctgc agaacatcaa tctggcaatg agcccactgc ctaccgcaga gacaccaaag 1380
ccactgaggt ctagcgccga cccagccctg aaccaggagg tggccctgaa gctggagcct 1440
aatccagagt ccctggagct gtcttttaca atgccacaga tccaggacca gaccccatcc 1500
ccttctgatg gcagcacacg ccagtcctct ccagagccca acagcccttc cgagtactgc 1560
ttctatgtgg attccgacat ggtgaatgag ttcaagctgg agctggtgga gaagctgttt 1620
gccgaggata ccgaggccaa gaaccccttc agcacccagg atacagacct ggatctggag 1680
atgctggccc cctatatccc tatggacgat gacttccagc tgcggtcctt tgaccagctg 1740
tctcctctgg agagctcctc tgcctcccct gagtctgcca gcccacagtc taccgtgaca 1800
gtgttccagc agacccagat ccaggagcca acagccaatg ccaccacaac cacagccacc 1860
acagatgagc tgaagaccgt gacaaaggac cggatggagg acatcaagat cctgatcgcc 1920
tccccttctc caacccacat ccacaaggag accacatccg ccacaagctc cccttaccgg 1980
gacacccaga gcagaacagc ctccccaaac agagccggca agggcgtgat cgagcagacc 2040
gagaagtctc acccaaggag ccccaatgtg ctgtccgtgg ccctgtctca gcgcaccaca 2100
gtgcccgagg aggagctgaa ccctaagatc ctggccctgc agaatgccca gcggaagaga 2160
aagatggagc acgatggaag cctgttccag gcagtgggaa tcggcaccct gctgcagcag 2220
ccagatgacc acgccgccac cacaagcctg tcctggaaga gggtgaaggg ctgtaagtct 2280
agcgagcaga acggcatgga gcagaagacc atcatcctga tcccatccga cctggcatgc 2340
aggctgctgg gccagagcat ggatgagtcc ggcctgcccc agctgacaag ctacgactgt 2400
gaggtgaacg cccctatcca gggctcccgg aatctgctgc agggcgagga gctgctgaga 2460
gccctggacc aggtgaat                                               2478

<210> 80
<211> 1005
<212> DNA
<213> Artificial Sequence

<220> 
<223> MOGAT1

<400> 80
atgaaggtgg agttcgcccc tctgaacatc cagctggccc ggagactgca gaccgtggcc 60
gtgctgcagt gggtgctgaa gtacctgctg ctgggcccaa tgtccatcgg catcacagtg 120
atgctgatca tccacaatta cctgttcctg tatatcccct atctgatgtg gctgtatttt 180
gactggcaca cccctgagag gggcggcagg cgcagctcct ggatcaagaa ctggacactg 240
tggaagcact tcaaggatta ctttccaatc cacctgatca agacccagga cctggatcct 300
tctcacaatt atatcttcgg ctttcaccca cacggaatca tggcagtggg agccttcggc 360
aactttagcg tgaattactc cgacttcaag gatctgttcc ccggctttac cagctatctg 420
cacgtgctgc cactgtggtt ctggtgcccc gtgtttagag agtacgtgat gtccgtgggc 480
ctggtgtctg tgagcaagaa gtccgtgtct tatatggtgt ccaaggaggg cggcggcaac 540
atctctgtga tcgtgctggg aggagcaaag gagtctctgg acgcccaccc tggcaagttc 600
accctgttta tccggcagag aaagggcttt gtgaagatcg ccctgacaca cggagcctct 660
ctggtgccag tggtgagctt cggcgagaac gagctgttta agcagaccga taatcccgag 720
ggcagctgga tcaggacagt gcagaacaag ctgcagaaga tcatgggctt cgcactgcca 780
ctgtttcacg caaggggcgt gttccagtac aattttggcc tgatgaccta tagaaaggcc 840
atccacacag tggtgggcag gcccatccct gtgcgccaga ccctgaatcc cacacaggag 900
cagatcgagg agctgcacca gacctacatg gaggagctgc gcaagctgtt cgaggagcac 960
aagggcaagt atggcatccc tgagcacgag acactggtgc tgaag                 1005

<210> 81
<211> 1866
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCK1

<400> 81
atgccccctc agctgcagaa cggcctgaat ctgtccgcca aggtggtgca gggctccctg 60
gactctctgc ctcaggccgt gagggagttt ctggagaaca atgccgagct gtgccagcca 120
gaccacatcc acatctgtga tggctctgag gaggagaacg gccgcctgct gggacagatg 180
gaggaggagg gcatcctgcg gagactgaag aagtacgata attgctggct ggccctgacc 240
gacccaaggg atgtggcacg catcgagagc aagaccgtga tcgtgacaca ggagcagagg 300
gacaccgtgc caatccccaa gacaggcctg tctcagctgg gccgctggat gagcgaggag 360
gatttcgaga aggcctttaa cgcccggttc cctggctgta tgaagggcag aaccatgtac 420
gtgatcccct tcagcatggg acctctggga agcccactgt ccaagatcgg catcgagctg 480
acagactccc catatgtggt ggcctctatg cggatcatga ccagaatggg aacacccgtg 540
ctggaggcag tgggcgatgg cgagttcgtg aagtgcctgc actccgtggg ctgtcctctg 600
ccactgcaga agcccctggt gaacaattgg ccctgcaacc ctgagctgac cctgatcgca 660
cacctgcctg acaggaggga gatcatctct tttggcagcg gctacggcgg caatagcctg 720
ctgggcaaga agtgtttcgc actgaggatg gcctcccgcc tggccaagga ggagggatgg 780
ctggccgagc acatgctgat cctgggcatc accaatcccg agggcgagaa gaagtatctg 840
gctgccgcct ttccttctgc ctgcggcaag acaaacctgg ccatgatgaa tccaagcctg 900
ccaggatgga aggtggagtg cgtgggcgac gacatcgcct ggatgaagtt cgatgcacag 960
ggacacctga gggccatcaa cccagagaat ggcttctttg gcgtggcccc aggcacctct 1020
gtgaagacaa accccaatgc catcaagacc atccagaaga acaccatctt tacaaatgtg 1080
gccgagacaa gcgacggagg cgtgtactgg gagggaatcg atgagcccct ggccagcggc 1140
gtgaccatca catcctggaa gaacaaggag tggagctccg aggacggaga gccatgcgca 1200
caccctaatt ccagattctg cacccccgcc tctcagtgtc ctatcatcga tgcagcatgg 1260
gagtctccag agggagtgcc aatcgagggc atcatctttg gcggccggag acctgcagga 1320
gtgccactgg tgtatgaggc cctgtcctgg cagcacggcg tgttcgtggg agcagcaatg 1380
cggtctgagg caacagctgc cgccgagcac aagggcaaga tcatcatgca cgacccattt 1440
gccatgagac ccttctttgg ctacaacttc ggcaagtatc tggcacactg gctgtccatg 1500
gcacagcacc ctgcagcaaa gctgccaaag atctttcacg tgaattggtt caggaaggat 1560
aaggagggca agtttctgtg gcctggcttc ggcgagaaca gcagggtgct ggagtggatg 1620
ttcaatcgca tcgacggcaa ggcctccacc aagctgacac ccatcggcta catccctaag 1680
gaggatgccc tgaacctgaa gggcctgggc cacatcaata tgatggagct gttttctatc 1740
agcaaggagt tctgggagaa ggaggtggag gacatcgaga agtatctgga ggaccaggtg 1800
aacgccgatc tgccctgtga gatcgagcgg gagatcctgg ccctgaagca gagaatctcc 1860
cagatg                                                            1866

<210> 82
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 82
Gly Gly Gly Ser Gly Gly Gly Ser
 1               5              


<210> 83
<211> 335
<212> PRT
<213> Artificial Sequence

<220> 
<223> tEGFR

<400> 83
Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu
 1               5                  10                  15      
Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile
            20                  25                  30          
Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe
        35                  40                  45              
Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr
    50                  55                  60                  
Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn
65                  70                  75                  80  
Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg
                85                  90                  95      
Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile
            100                 105                 110         
Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val
        115                 120                 125             
Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp
    130                 135                 140                 
Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn
145                 150                 155                 160 
Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu
                165                 170                 175     
Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser
            180                 185                 190         
Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu
        195                 200                 205             
Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln
    210                 215                 220                 
Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly
225                 230                 235                 240 
Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro
                245                 250                 255     
His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr
            260                 265                 270         
Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His
        275                 280                 285             
Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro
    290                 295                 300                 
Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala
305                 310                 315                 320 
Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met
                325                 330                 335 


<210> 84
<211> 1755
<212> DNA
<213> Artificial Sequence

<220> 
<223> huLEM-T2A-Her2t

<400> 84
atgagggaaa gccaggatgc cgccggagct catggctgga accgcgtcgg ctccacggcc 60
accaagtggt tcaccggggc gcccttcggg gtgcagagcc acaggtttga catctctgct 120
gtttatccca actggaagaa gttcagcacc ttcactgagg ccccatactc cacgcgttat 180
tctacccaag tgtcccacat aggccctggg acttacagct ccaaagagac ctgcttcagc 240
aagaagaagc tgatgaagga ggtggacaca ggctgggcca aggcccagga agccacgcgg 300
ctgacccagc taccccactt ccagtaccag gccatcatga aagagaagcg gctgaaggag 360
caaaagctgg gccccggctc ctacaacctc aaagacttct tagaacagct gcgggagaaa 420
ccatgtagca cccgggggct gctcagctct ggggaggttc gcttccgagg actcactggg 480
aactactatc caggccctgg aaattatggg gagaagggta acccatacac caagctggag 540
gagaatgcct ggaaccggtc tcattccgag ggcctcatgt gcaggatgag caacaagcca 600
cacccccggc ctcatcaggg gagtggtctg ggacccggca cctacttctt caaaagcgac 660
cttgagacat atgtggcacg atccgtcggc acccgcggcc cctatgacac tttctctggt 720
gatcggagca agccactgcc ttatgggcac tactccatgc agaaaaaaaa gcccagggaa 780
ctgatgaatt tcaagagctt tgtagaagaa cttaactcac atcacaataa gaagcatggg 840
gttttttcta aacttccccg aaacccgaaa acccctacag agaggattta ctgggccaac 900
ctcagccagt gcccccgcac actggccaca tctggcccca gtttctggct tccacaagag 960
aagaaatgca aacccgtcaa ccagccccca ttcctgttga cctccaaggg gtcaggtgca 1020
aaggcctgcc agatgattat gggaagctgg aacccagtag gtgtgggccg ctacctcaac 1080
acctggctga tggagacaaa ggacaggcgg cagcgatatc gatccctatt cctgagtgga 1140
tccaaacgct acctctcaga cctggcccgg gacatgctca tgcaggaaag gatcacacca 1200
tttactaagg gaaagtgccc tccaactgtg gattacaatt cagatcctac tcctctcgag 1260
ggcggcggag agggcagagg aagtcttcta acatgcggtg acgtggagga gaatcccggc 1320
cctaggatgc ttctcctggt gacaagcctt ctgctctgtg agttaccaca cccagcattc 1380
ctcctgatcc catgccaccc tgagtgtcag ccccagaatg gctcagtgac ctgttttgga 1440
ccggaggctg accagtgtgt ggcctgtgcc cactataagg accctccctt ctgcgtggcc 1500
cgctgcccca gcggtgtgaa acctgacctc tcctacatgc ccatctggaa gtttccagat 1560
gaggagggcg catgccagcc ttgccccatc aactgcaccc actcctgtgt ggacctggat 1620
gacaagggct gccccgccga gcagagagcc agccctctga cgggtggagg aagcggaggt 1680
ggcagctcca tcatctctgc ggtggttggc attctgctgg tcgtggtctt gggggtggtc 1740
tttgggatcc tcatc                                                  1755

<210> 85
<211> 585
<212> PRT
<213> Artificial Sequence

<220> 
<223> huLEM-T2A-Her2t

<400> 85
Met Arg Glu Ser Gln Asp Ala Ala Gly Ala His Gly Trp Asn Arg Val
 1               5                  10                  15      
Gly Ser Thr Ala Thr Lys Trp Phe Thr Gly Ala Pro Phe Gly Val Gln
            20                  25                  30          
Ser His Arg Phe Asp Ile Ser Ala Val Tyr Pro Asn Trp Lys Lys Phe
        35                  40                  45              
Ser Thr Phe Thr Glu Ala Pro Tyr Ser Thr Arg Tyr Ser Thr Gln Val
    50                  55                  60                  
Ser His Ile Gly Pro Gly Thr Tyr Ser Ser Lys Glu Thr Cys Phe Ser
65                  70                  75                  80  
Lys Lys Lys Leu Met Lys Glu Val Asp Thr Gly Trp Ala Lys Ala Gln
                85                  90                  95      
Glu Ala Thr Arg Leu Thr Gln Leu Pro His Phe Gln Tyr Gln Ala Ile
            100                 105                 110         
Met Lys Glu Lys Arg Leu Lys Glu Gln Lys Leu Gly Pro Gly Ser Tyr
        115                 120                 125             
Asn Leu Lys Asp Phe Leu Glu Gln Leu Arg Glu Lys Pro Cys Ser Thr
    130                 135                 140                 
Arg Gly Leu Leu Ser Ser Gly Glu Val Arg Phe Arg Gly Leu Thr Gly
145                 150                 155                 160 
Asn Tyr Tyr Pro Gly Pro Gly Asn Tyr Gly Glu Lys Gly Asn Pro Tyr
                165                 170                 175     
Thr Lys Leu Glu Glu Asn Ala Trp Asn Arg Ser His Ser Glu Gly Leu
            180                 185                 190         
Met Cys Arg Met Ser Asn Lys Pro His Pro Arg Pro His Gln Gly Ser
        195                 200                 205             
Gly Leu Gly Pro Gly Thr Tyr Phe Phe Lys Ser Asp Leu Glu Thr Tyr
    210                 215                 220                 
Val Ala Arg Ser Val Gly Thr Arg Gly Pro Tyr Asp Thr Phe Ser Gly
225                 230                 235                 240 
Asp Arg Ser Lys Pro Leu Pro Tyr Gly His Tyr Ser Met Gln Lys Lys
                245                 250                 255     
Lys Pro Arg Glu Leu Met Asn Phe Lys Ser Phe Val Glu Glu Leu Asn
            260                 265                 270         
Ser His His Asn Lys Lys His Gly Val Phe Ser Lys Leu Pro Arg Asn
        275                 280                 285             
Pro Lys Thr Pro Thr Glu Arg Ile Tyr Trp Ala Asn Leu Ser Gln Cys
    290                 295                 300                 
Pro Arg Thr Leu Ala Thr Ser Gly Pro Ser Phe Trp Leu Pro Gln Glu
305                 310                 315                 320 
Lys Lys Cys Lys Pro Val Asn Gln Pro Pro Phe Leu Leu Thr Ser Lys
                325                 330                 335     
Gly Ser Gly Ala Lys Ala Cys Gln Met Ile Met Gly Ser Trp Asn Pro
            340                 345                 350         
Val Gly Val Gly Arg Tyr Leu Asn Thr Trp Leu Met Glu Thr Lys Asp
        355                 360                 365             
Arg Arg Gln Arg Tyr Arg Ser Leu Phe Leu Ser Gly Ser Lys Arg Tyr
    370                 375                 380                 
Leu Ser Asp Leu Ala Arg Asp Met Leu Met Gln Glu Arg Ile Thr Pro
385                 390                 395                 400 
Phe Thr Lys Gly Lys Cys Pro Pro Thr Val Asp Tyr Asn Ser Asp Pro
                405                 410                 415     
Thr Pro Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys
            420                 425                 430         
Gly Asp Val Glu Glu Asn Pro Gly Pro Arg Met Leu Leu Leu Val Thr
        435                 440                 445             
Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu Ile Pro
    450                 455                 460                 
Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Phe Gly
465                 470                 475                 480 
Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro
                485                 490                 495     
Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr
            500                 505                 510         
Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys
        515                 520                 525             
Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys Gly Cys
    530                 535                 540                 
Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Gly Gly Gly Ser Gly Gly
545                 550                 555                 560 
Gly Ser Ser Ile Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val
                565                 570                 575     
Leu Gly Val Val Phe Gly Ile Leu Ile
            580                 585 


<210> 86
<211> 1965
<212> DNA
<213> Artificial Sequence

<220> 
<223> DGAT1-T2A-Her2t

<400> 86
atgggcgatc gcggcagctc ccggagaagg cgcaccggca gccggccctc tagccacggc 60
ggcggcggcc ctgctgccgc cgaggaggag gtgcgcgacg ccgccgccgg ccctgatgtg 120
ggagcagcag gcgacgcacc agcacctgcc ccaaacaagg acggcgatgc aggagtggga 180
agcggacact gggagctgag atgccacagg ctgcaggatt ccctgttctc ctctgacagc 240
ggcttttcca actacagagg catcctgaat tggtgcgtgg tcatgctgat cctgtccaac 300
gccaggctgt tcctggagaa tctgatcaag tacggcatcc tggtggatcc tatccaggtg 360
gtgagcctgt ttctgaagga cccatattcc tggccagcac cttgcctggt catcgcagca 420
aacgtgttcg cagtggcagc ctttcaggtg gagaagcggc tggccgtggg cgccctgacc 480
gagcaggcag gcctgctgct gcacgtggcc aatctggcca caatcctgtg cttcccagca 540
gcagtggtgc tgctggtgga gtctatcacc cctgtgggaa gcctgctggc cctgatggca 600
cacacaatcc tgttcctgaa gctgttttcc tacagagacg tgaattcttg gtgtaggaga 660
gcaagggcaa aggcagcctc tgccggcaag aaggccagca gcgccgccgc ccctcacacc 720
gtgagctacc cagataacct gacatataga gacctgtact atttcctgtt tgcccccacc 780
ctgtgctatg agctgaattt cccaaggtcc cccaggatcc gcaagcggtt tctgctgagg 840
cgcatcctgg agatgctgtt ctttacccag ctgcaagtgg gcctgatcca gcagtggatg 900
gtgccaacaa tccagaactc catgaagccc ttcaaggaca tggattactc tagaatcatc 960
gagaggctgc tgaagctggc cgtgcccaac cacctgatct ggctgatctt cttttattgg 1020
ctgtttcact cttgcctgaa tgccgtggcc gagctgatgc agttcggcga tcgcgagttt 1080
taccgggact ggtggaattc cgagtctgtg acatatttct ggcagaactg gaatatccca 1140
gtgcacaagt ggtgtatccg ccacttttac aagcccatgc tgcggagagg ctctagcaag 1200
tggatggcca gaaccggcgt gttcctggcc tctgccttct ttcacgagta tctggtgagc 1260
gtgcctctgc gcatgttccg gctgtgggcc tttacaggca tgatggccca gatcccactg 1320
gcctggtttg tgggccggtt ctttcagggc aactacggca atgccgccgt gtggctgagc 1380
ctgatcatcg gccagcccat cgccgtgctg atgtacgtgc acgattacta tgtgctgaac 1440
tatgaggccc ctgccgccga ggccctcgag ggcggcggag agggcagagg aagtcttcta 1500
acatgcggtg acgtggagga gaatcccggc cctaggatgc ttctcctggt gacaagcctt 1560
ctgctctgtg agttaccaca cccagcattc ctcctgatcc catgccaccc tgagtgtcag 1620
ccccagaatg gctcagtgac ctgttttgga ccggaggctg accagtgtgt ggcctgtgcc 1680
cactataagg accctccctt ctgcgtggcc cgctgcccca gcggtgtgaa acctgacctc 1740
tcctacatgc ccatctggaa gtttccagat gaggagggcg catgccagcc ttgccccatc 1800
aactgcaccc actcctgtgt ggacctggat gacaagggct gccccgccga gcagagagcc 1860
agccctctga cgggtggagg aagcggaggt ggcagctcca tcatctctgc ggtggttggc 1920
attctgctgg tcgtggtctt gggggtggtc tttgggatcc tcatc                 1965

<210> 87
<211> 655
<212> PRT
<213> Artificial Sequence

<220> 
<223> DGAT1-T2A-Her2t

<400> 87
Met Gly Asp Arg Gly Ser Ser Arg Arg Arg Arg Thr Gly Ser Arg Pro
 1               5                  10                  15      
Ser Ser His Gly Gly Gly Gly Pro Ala Ala Ala Glu Glu Glu Val Arg
            20                  25                  30          
Asp Ala Ala Ala Gly Pro Asp Val Gly Ala Ala Gly Asp Ala Pro Ala
        35                  40                  45              
Pro Ala Pro Asn Lys Asp Gly Asp Ala Gly Val Gly Ser Gly His Trp
    50                  55                  60                  
Glu Leu Arg Cys His Arg Leu Gln Asp Ser Leu Phe Ser Ser Asp Ser
65                  70                  75                  80  
Gly Phe Ser Asn Tyr Arg Gly Ile Leu Asn Trp Cys Val Val Met Leu
                85                  90                  95      
Ile Leu Ser Asn Ala Arg Leu Phe Leu Glu Asn Leu Ile Lys Tyr Gly
            100                 105                 110         
Ile Leu Val Asp Pro Ile Gln Val Val Ser Leu Phe Leu Lys Asp Pro
        115                 120                 125             
Tyr Ser Trp Pro Ala Pro Cys Leu Val Ile Ala Ala Asn Val Phe Ala
    130                 135                 140                 
Val Ala Ala Phe Gln Val Glu Lys Arg Leu Ala Val Gly Ala Leu Thr
145                 150                 155                 160 
Glu Gln Ala Gly Leu Leu Leu His Val Ala Asn Leu Ala Thr Ile Leu
                165                 170                 175     
Cys Phe Pro Ala Ala Val Val Leu Leu Val Glu Ser Ile Thr Pro Val
            180                 185                 190         
Gly Ser Leu Leu Ala Leu Met Ala His Thr Ile Leu Phe Leu Lys Leu
        195                 200                 205             
Phe Ser Tyr Arg Asp Val Asn Ser Trp Cys Arg Arg Ala Arg Ala Lys
    210                 215                 220                 
Ala Ala Ser Ala Gly Lys Lys Ala Ser Ser Ala Ala Ala Pro His Thr
225                 230                 235                 240 
Val Ser Tyr Pro Asp Asn Leu Thr Tyr Arg Asp Leu Tyr Tyr Phe Leu
                245                 250                 255     
Phe Ala Pro Thr Leu Cys Tyr Glu Leu Asn Phe Pro Arg Ser Pro Arg
            260                 265                 270         
Ile Arg Lys Arg Phe Leu Leu Arg Arg Ile Leu Glu Met Leu Phe Phe
        275                 280                 285             
Thr Gln Leu Gln Val Gly Leu Ile Gln Gln Trp Met Val Pro Thr Ile
    290                 295                 300                 
Gln Asn Ser Met Lys Pro Phe Lys Asp Met Asp Tyr Ser Arg Ile Ile
305                 310                 315                 320 
Glu Arg Leu Leu Lys Leu Ala Val Pro Asn His Leu Ile Trp Leu Ile
                325                 330                 335     
Phe Phe Tyr Trp Leu Phe His Ser Cys Leu Asn Ala Val Ala Glu Leu
            340                 345                 350         
Met Gln Phe Gly Asp Arg Glu Phe Tyr Arg Asp Trp Trp Asn Ser Glu
        355                 360                 365             
Ser Val Thr Tyr Phe Trp Gln Asn Trp Asn Ile Pro Val His Lys Trp
    370                 375                 380                 
Cys Ile Arg His Phe Tyr Lys Pro Met Leu Arg Arg Gly Ser Ser Lys
385                 390                 395                 400 
Trp Met Ala Arg Thr Gly Val Phe Leu Ala Ser Ala Phe Phe His Glu
                405                 410                 415     
Tyr Leu Val Ser Val Pro Leu Arg Met Phe Arg Leu Trp Ala Phe Thr
            420                 425                 430         
Gly Met Met Ala Gln Ile Pro Leu Ala Trp Phe Val Gly Arg Phe Phe
        435                 440                 445             
Gln Gly Asn Tyr Gly Asn Ala Ala Val Trp Leu Ser Leu Ile Ile Gly
    450                 455                 460                 
Gln Pro Ile Ala Val Leu Met Tyr Val His Asp Tyr Tyr Val Leu Asn
465                 470                 475                 480 
Tyr Glu Ala Pro Ala Ala Glu Ala Leu Glu Gly Gly Gly Glu Gly Arg
                485                 490                 495     
Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Arg
            500                 505                 510         
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
        515                 520                 525             
Ala Phe Leu Leu Ile Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly
    530                 535                 540                 
Ser Val Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala
545                 550                 555                 560 
His Tyr Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val
                565                 570                 575     
Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu
            580                 585                 590         
Gly Ala Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp
        595                 600                 605             
Leu Asp Asp Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr
    610                 615                 620                 
Gly Gly Gly Ser Gly Gly Gly Ser Ser Ile Ile Ser Ala Val Val Gly
625                 630                 635                 640 
Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly Ile Leu Ile
                645                 650                 655 


<210> 88
<211> 2178
<212> DNA
<213> Artificial Sequence

<220> 
<223> GYK-T2A-Her2t

<400> 88
atggcagcca gcaagaaggc cgtgctgggc ccactggtgg gagcagtgga ccagggcacc 60
agctccacaa ggttcctggt gtttaatagc aagaccgcag agctgctgtc ccaccaccag 120
gtggagatca agcaggagtt tccaagggag ggatgggtgg agcaggaccc aaaggagatc 180
ctgcactccg tgtacgagtg catcgagaag acctgtgaga agctgggcca gctgaatatc 240
gacatcagca acatcaaggc catcggcgtg tccaatcagc gggagaccac agtggtgtgg 300
gacaagatca caggcgagcc cctgtataac gccgtggtgt ggctggatct gaggacccag 360
agcacagtgg agtccctgtc taagcgcatc cctggcaaca ataactttgt gaagtccaag 420
accggcctgc cactgtccac atatttctct gccgtgaagc tgaggtggct gctggacaat 480
gtgcgcaagg tgcagaaggc cgtggaggag aagagggccc tgtttggcac catcgattct 540
tggctgatct ggagcctgac aggaggagtg aacggaggcg tgcactgcac cgacgtgaca 600
aatgcctctc ggaccatgct gttcaacatc cacagcctgg agtgggataa gcagctgtgc 660
gagttctttg gcatccctat ggagatcctg ccaaacgtga gatctagctc cgagatctat 720
ggcctgatga agatcagcca ctccgtgaag gcaggcgccc tggagggagt gcctatctct 780
ggatgcctgg gcgaccagag cgccgccctg gtgggacaga tgtgcttcca gatcggccag 840
gccaagaata cctacggcac aggctgcttt ctgctgtgca acaccggcca caagtgcgtg 900
ttcagcgacc acggcctgct gaccacagtg gcctataagc tgggcaggga taagcccgtg 960
tactatgcac tggagggatc tgtggcaatc gcaggagccg tgatcaggtg gctgagagat 1020
aatctgggca tcatcaagac cagcgaggag atcgagaagc tggccaagga agtgggcaca 1080
tcctacggct gttatttcgt gcctgccttt tctggcctgt acgcaccata ttgggagcca 1140
agcgccaggg gaatcatctg cggcctgacc cagttcacaa acaagtgtca catcgccttt 1200
gccgccctgg aggccgtgtg cttccagacc cgggagatcc tggacgccat gaatagagat 1260
tgtggcatcc ctctgtccca cctgcaggtg gacggaggca tgacatctaa caagatcctg 1320
atgcagctgc aggccgacat cctgtatatc ccagtggtga agccctccat gcctgagacc 1380
acagccctgg gagcagcaat ggcagcagga gcagccgagg gcgtgggcgt gtggtccctg 1440
gagccagagg acctgtctgc cgtgaccatg gagcggtttg agcctcagat caatgccgag 1500
gagtccgaga tcagatactc tacatggaag aaggccgtga tgaagtccat gggctgggtg 1560
accacacagt ctcccgagag cggcgatcct agcatcttct gctccctgcc actgggcttc 1620
tttatcgtgt ctagcatggt catgctgatc ggcgcccggt atatctctgg catccccctc 1680
gagggcggcg gagagggcag aggaagtctt ctaacatgcg gtgacgtgga ggagaatccc 1740
ggccctagga tgcttctcct ggtgacaagc cttctgctct gtgagttacc acacccagca 1800
ttcctcctga tcccatgcca ccctgagtgt cagccccaga atggctcagt gacctgtttt 1860
ggaccggagg ctgaccagtg tgtggcctgt gcccactata aggaccctcc cttctgcgtg 1920
gcccgctgcc ccagcggtgt gaaacctgac ctctcctaca tgcccatctg gaagtttcca 1980
gatgaggagg gcgcatgcca gccttgcccc atcaactgca cccactcctg tgtggacctg 2040
gatgacaagg gctgccccgc cgagcagaga gccagccctc tgacgggtgg aggaagcgga 2100
ggtggcagct ccatcatctc tgcggtggtt ggcattctgc tggtcgtggt cttgggggtg 2160
gtctttggga tcctcatc                                               2178

<210> 89
<211> 726
<212> PRT
<213> Artificial Sequence

<220> 
<223> GYK-T2A-Her2t

<400> 89
Met Ala Ala Ser Lys Lys Ala Val Leu Gly Pro Leu Val Gly Ala Val
 1               5                  10                  15      
Asp Gln Gly Thr Ser Ser Thr Arg Phe Leu Val Phe Asn Ser Lys Thr
            20                  25                  30          
Ala Glu Leu Leu Ser His His Gln Val Glu Ile Lys Gln Glu Phe Pro
        35                  40                  45              
Arg Glu Gly Trp Val Glu Gln Asp Pro Lys Glu Ile Leu His Ser Val
    50                  55                  60                  
Tyr Glu Cys Ile Glu Lys Thr Cys Glu Lys Leu Gly Gln Leu Asn Ile
65                  70                  75                  80  
Asp Ile Ser Asn Ile Lys Ala Ile Gly Val Ser Asn Gln Arg Glu Thr
                85                  90                  95      
Thr Val Val Trp Asp Lys Ile Thr Gly Glu Pro Leu Tyr Asn Ala Val
            100                 105                 110         
Val Trp Leu Asp Leu Arg Thr Gln Ser Thr Val Glu Ser Leu Ser Lys
        115                 120                 125             
Arg Ile Pro Gly Asn Asn Asn Phe Val Lys Ser Lys Thr Gly Leu Pro
    130                 135                 140                 
Leu Ser Thr Tyr Phe Ser Ala Val Lys Leu Arg Trp Leu Leu Asp Asn
145                 150                 155                 160 
Val Arg Lys Val Gln Lys Ala Val Glu Glu Lys Arg Ala Leu Phe Gly
                165                 170                 175     
Thr Ile Asp Ser Trp Leu Ile Trp Ser Leu Thr Gly Gly Val Asn Gly
            180                 185                 190         
Gly Val His Cys Thr Asp Val Thr Asn Ala Ser Arg Thr Met Leu Phe
        195                 200                 205             
Asn Ile His Ser Leu Glu Trp Asp Lys Gln Leu Cys Glu Phe Phe Gly
    210                 215                 220                 
Ile Pro Met Glu Ile Leu Pro Asn Val Arg Ser Ser Ser Glu Ile Tyr
225                 230                 235                 240 
Gly Leu Met Lys Ile Ser His Ser Val Lys Ala Gly Ala Leu Glu Gly
                245                 250                 255     
Val Pro Ile Ser Gly Cys Leu Gly Asp Gln Ser Ala Ala Leu Val Gly
            260                 265                 270         
Gln Met Cys Phe Gln Ile Gly Gln Ala Lys Asn Thr Tyr Gly Thr Gly
        275                 280                 285             
Cys Phe Leu Leu Cys Asn Thr Gly His Lys Cys Val Phe Ser Asp His
    290                 295                 300                 
Gly Leu Leu Thr Thr Val Ala Tyr Lys Leu Gly Arg Asp Lys Pro Val
305                 310                 315                 320 
Tyr Tyr Ala Leu Glu Gly Ser Val Ala Ile Ala Gly Ala Val Ile Arg
                325                 330                 335     
Trp Leu Arg Asp Asn Leu Gly Ile Ile Lys Thr Ser Glu Glu Ile Glu
            340                 345                 350         
Lys Leu Ala Lys Glu Val Gly Thr Ser Tyr Gly Cys Tyr Phe Val Pro
        355                 360                 365             
Ala Phe Ser Gly Leu Tyr Ala Pro Tyr Trp Glu Pro Ser Ala Arg Gly
    370                 375                 380                 
Ile Ile Cys Gly Leu Thr Gln Phe Thr Asn Lys Cys His Ile Ala Phe
385                 390                 395                 400 
Ala Ala Leu Glu Ala Val Cys Phe Gln Thr Arg Glu Ile Leu Asp Ala
                405                 410                 415     
Met Asn Arg Asp Cys Gly Ile Pro Leu Ser His Leu Gln Val Asp Gly
            420                 425                 430         
Gly Met Thr Ser Asn Lys Ile Leu Met Gln Leu Gln Ala Asp Ile Leu
        435                 440                 445             
Tyr Ile Pro Val Val Lys Pro Ser Met Pro Glu Thr Thr Ala Leu Gly
    450                 455                 460                 
Ala Ala Met Ala Ala Gly Ala Ala Glu Gly Val Gly Val Trp Ser Leu
465                 470                 475                 480 
Glu Pro Glu Asp Leu Ser Ala Val Thr Met Glu Arg Phe Glu Pro Gln
                485                 490                 495     
Ile Asn Ala Glu Glu Ser Glu Ile Arg Tyr Ser Thr Trp Lys Lys Ala
            500                 505                 510         
Val Met Lys Ser Met Gly Trp Val Thr Thr Gln Ser Pro Glu Ser Gly
        515                 520                 525             
Asp Pro Ser Ile Phe Cys Ser Leu Pro Leu Gly Phe Phe Ile Val Ser
    530                 535                 540                 
Ser Met Val Met Leu Ile Gly Ala Arg Tyr Ile Ser Gly Ile Pro Leu
545                 550                 555                 560 
Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val
                565                 570                 575     
Glu Glu Asn Pro Gly Pro Arg Met Leu Leu Leu Val Thr Ser Leu Leu
            580                 585                 590         
Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu Ile Pro Cys His Pro
        595                 600                 605             
Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Phe Gly Pro Glu Ala
    610                 615                 620                 
Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro Phe Cys Val
625                 630                 635                 640 
Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met Pro Ile
                645                 650                 655     
Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys Pro Ile Asn
            660                 665                 670         
Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys Gly Cys Pro Ala Glu
        675                 680                 685             
Gln Arg Ala Ser Pro Leu Thr Gly Gly Gly Ser Gly Gly Gly Ser Ser
    690                 695                 700                 
Ile Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val
705                 710                 715                 720 
Val Phe Gly Ile Leu Ile
                725     


<210> 90
<211> 2985
<212> DNA
<213> Artificial Sequence

<220> 
<223> GPAM-T2A-Her2t

<400> 90
atggacgagt ccgccctgac actgggcacc atcgacgtga gctacctgcc acacagctcc 60
gagtattctg tgggcaggtg caagcacaca agcgaggagt ggggagagtg tggcttccgg 120
ccaacaatct ttagatccgc caccctgaag tggaaggaga gcctgatgtc ccggaagaga 180
ccattcgtgg gccggtgctg ttactcctgc accccccagt cttgggacaa gttctttaac 240
ccttctatcc caagcctggg cctgagaaac gtgatctaca tcaatgagac ccacacaagg 300
cacaggggat ggctggcccg gagactgagc tatgtgctgt tcatccagga gagggacgtg 360
cacaagggca tgtttgccac aaatgtgacc gagaacgtgc tgaattctag ccgcgtgcag 420
gaggcaatcg cagaggtggc agcagagctg aaccctgatg gaagcgccca gcagcagtcc 480
aaggcagtga ataaggtgaa gaagaaggcc aagcggatcc tgcaggagat ggtggccaca 540
gtgtccccag ccatgatcag actgaccggc tgggtgctgc tgaagctgtt caactctttc 600
ttttggaata tccagatcca caagggccag ctggagatgg tgaaggccgc caccgagaca 660
aacctgccac tgctgtttct gcccgtgcac cgcagccaca tcgattacct gctgctgacc 720
ttcatcctgt tttgtcacaa catcaaggcc ccttatatcg ccagcggcaa caatctgaat 780
atcccaatct tctccacact gatccacaag ctgggcggct tctttatcag gcgccggctg 840
gatgagaccc ctgacggcag gaaggatgtg ctgtaccgcg ccctgctgca cggacacatc 900
gtggagctgc tgaggcagca gcagttcctg gagatctttc tggagggcac acggtctaga 960
agcggcaaga cctcctgcgc aagggcagga ctgctgtccg tggtggtgga cacactgtct 1020
accaacgtga tccccgacat cctgatcatc cctgtgggca tctcttacga ccggatcatc 1080
gagggccact ataacggcga gcagctgggc aagcccaaga agaatgagtc cctgtggtct 1140
gtggccaggg gcgtgatccg gatgctgaga aagaattacg gatgcgtgcg ggtggatttc 1200
gcacagcctt tttccctgaa ggagtatctg gagtcccagt ctcagaagcc cgtgagcgcc 1260
ctgctgtccc tggagcaggc cctgctgcct gcaatcctgc caagcagacc ttccgatgca 1320
gcagacgagg gaagggacac atctatcaac gagagcagaa atgccaccga tgagagcctg 1380
agaaggcgcc tgatcgccaa cctggccgag cacatcctgt tcacagccag caagtcctgc 1440
gccatcatga gcacccacat cgtggcctgt ctgctgctgt accggcacag gcagggaatc 1500
gacctgtcca cactggtgga ggatttcttt gtgatgaagg aggaggtgct ggccagggac 1560
ttcgatctgg gcttttctgg caatagcgag gacgtggtca tgcacgccat ccagctgctg 1620
ggcaactgcg tgaccatcac acacacctcc cgcaatgatg agttctttat caccccttct 1680
accacagtgc caagcgtgtt cgagctgaac ttttactcta atggcgtgct gcacgtgttt 1740
atcatggagg ccatcatcgc ctgcagcctg tatgccgtgc tgaacaagag gggactgggc 1800
ggcccaacaa gcaccccccc taatctgatc tcccaggagc agctggtgag aaaggccgcc 1860
tccctgtgct atctgctgtc taacgagggc acaatcagcc tgccctgcca gaccttctac 1920
caggtgtgcc acgagacagt gggcaagttt atccagtatg gcatcctgac cgtggccgag 1980
cacgacgatc aggaggacat ctctcctagc ctggccgagc agcagtggga taagaagctg 2040
ccagagcccc tgtcctggag gtctgacgag gaggacgagg atagcgactt cggcgaggag 2100
cagcgcgatt gttacctgaa ggtgtcccag tctaaggagc accagcagtt catcaccttt 2160
ctgcagcggc tgctgggccc actgctggag gcctattcct ctgccgccat cttcgtgcac 2220
aacttttccg gccctgtgcc agagccagag tacctgcaga agctgcacaa gtatctgatc 2280
acaaggaccg agaggaacgt ggccgtgtac gcagagagcg ccacctattg cctggtgaag 2340
aatgccgtga agatgttcaa ggacatcggc gtgtttaagg agacaaagca gaagcgggtg 2400
tctgtgctgg agctgagctc caccttcctg ccccagtgta atagacagaa gctgctggag 2460
tacatcctga gctttgtggt gctgctcgag ggcggcggag agggcagagg aagtcttcta 2520
acatgcggtg acgtggagga gaatcccggc cctaggatgc ttctcctggt gacaagcctt 2580
ctgctctgtg agttaccaca cccagcattc ctcctgatcc catgccaccc tgagtgtcag 2640
ccccagaatg gctcagtgac ctgttttgga ccggaggctg accagtgtgt ggcctgtgcc 2700
cactataagg accctccctt ctgcgtggcc cgctgcccca gcggtgtgaa acctgacctc 2760
tcctacatgc ccatctggaa gtttccagat gaggagggcg catgccagcc ttgccccatc 2820
aactgcaccc actcctgtgt ggacctggat gacaagggct gccccgccga gcagagagcc 2880
agccctctga cgggtggagg aagcggaggt ggcagctcca tcatctctgc ggtggttggc 2940
attctgctgg tcgtggtctt gggggtggtc tttgggatcc tcatc                 2985

<210> 91
<211> 995
<212> PRT
<213> Artificial Sequence

<220> 
<223> GPAM-T2A-Her2t

<400> 91
Met Asp Glu Ser Ala Leu Thr Leu Gly Thr Ile Asp Val Ser Tyr Leu
 1               5                  10                  15      
Pro His Ser Ser Glu Tyr Ser Val Gly Arg Cys Lys His Thr Ser Glu
            20                  25                  30          
Glu Trp Gly Glu Cys Gly Phe Arg Pro Thr Ile Phe Arg Ser Ala Thr
        35                  40                  45              
Leu Lys Trp Lys Glu Ser Leu Met Ser Arg Lys Arg Pro Phe Val Gly
    50                  55                  60                  
Arg Cys Cys Tyr Ser Cys Thr Pro Gln Ser Trp Asp Lys Phe Phe Asn
65                  70                  75                  80  
Pro Ser Ile Pro Ser Leu Gly Leu Arg Asn Val Ile Tyr Ile Asn Glu
                85                  90                  95      
Thr His Thr Arg His Arg Gly Trp Leu Ala Arg Arg Leu Ser Tyr Val
            100                 105                 110         
Leu Phe Ile Gln Glu Arg Asp Val His Lys Gly Met Phe Ala Thr Asn
        115                 120                 125             
Val Thr Glu Asn Val Leu Asn Ser Ser Arg Val Gln Glu Ala Ile Ala
    130                 135                 140                 
Glu Val Ala Ala Glu Leu Asn Pro Asp Gly Ser Ala Gln Gln Gln Ser
145                 150                 155                 160 
Lys Ala Val Asn Lys Val Lys Lys Lys Ala Lys Arg Ile Leu Gln Glu
                165                 170                 175     
Met Val Ala Thr Val Ser Pro Ala Met Ile Arg Leu Thr Gly Trp Val
            180                 185                 190         
Leu Leu Lys Leu Phe Asn Ser Phe Phe Trp Asn Ile Gln Ile His Lys
        195                 200                 205             
Gly Gln Leu Glu Met Val Lys Ala Ala Thr Glu Thr Asn Leu Pro Leu
    210                 215                 220                 
Leu Phe Leu Pro Val His Arg Ser His Ile Asp Tyr Leu Leu Leu Thr
225                 230                 235                 240 
Phe Ile Leu Phe Cys His Asn Ile Lys Ala Pro Tyr Ile Ala Ser Gly
                245                 250                 255     
Asn Asn Leu Asn Ile Pro Ile Phe Ser Thr Leu Ile His Lys Leu Gly
            260                 265                 270         
Gly Phe Phe Ile Arg Arg Arg Leu Asp Glu Thr Pro Asp Gly Arg Lys
        275                 280                 285             
Asp Val Leu Tyr Arg Ala Leu Leu His Gly His Ile Val Glu Leu Leu
    290                 295                 300                 
Arg Gln Gln Gln Phe Leu Glu Ile Phe Leu Glu Gly Thr Arg Ser Arg
305                 310                 315                 320 
Ser Gly Lys Thr Ser Cys Ala Arg Ala Gly Leu Leu Ser Val Val Val
                325                 330                 335     
Asp Thr Leu Ser Thr Asn Val Ile Pro Asp Ile Leu Ile Ile Pro Val
            340                 345                 350         
Gly Ile Ser Tyr Asp Arg Ile Ile Glu Gly His Tyr Asn Gly Glu Gln
        355                 360                 365             
Leu Gly Lys Pro Lys Lys Asn Glu Ser Leu Trp Ser Val Ala Arg Gly
    370                 375                 380                 
Val Ile Arg Met Leu Arg Lys Asn Tyr Gly Cys Val Arg Val Asp Phe
385                 390                 395                 400 
Ala Gln Pro Phe Ser Leu Lys Glu Tyr Leu Glu Ser Gln Ser Gln Lys
                405                 410                 415     
Pro Val Ser Ala Leu Leu Ser Leu Glu Gln Ala Leu Leu Pro Ala Ile
            420                 425                 430         
Leu Pro Ser Arg Pro Ser Asp Ala Ala Asp Glu Gly Arg Asp Thr Ser
        435                 440                 445             
Ile Asn Glu Ser Arg Asn Ala Thr Asp Glu Ser Leu Arg Arg Arg Leu
    450                 455                 460                 
Ile Ala Asn Leu Ala Glu His Ile Leu Phe Thr Ala Ser Lys Ser Cys
465                 470                 475                 480 
Ala Ile Met Ser Thr His Ile Val Ala Cys Leu Leu Leu Tyr Arg His
                485                 490                 495     
Arg Gln Gly Ile Asp Leu Ser Thr Leu Val Glu Asp Phe Phe Val Met
            500                 505                 510         
Lys Glu Glu Val Leu Ala Arg Asp Phe Asp Leu Gly Phe Ser Gly Asn
        515                 520                 525             
Ser Glu Asp Val Val Met His Ala Ile Gln Leu Leu Gly Asn Cys Val
    530                 535                 540                 
Thr Ile Thr His Thr Ser Arg Asn Asp Glu Phe Phe Ile Thr Pro Ser
545                 550                 555                 560 
Thr Thr Val Pro Ser Val Phe Glu Leu Asn Phe Tyr Ser Asn Gly Val
                565                 570                 575     
Leu His Val Phe Ile Met Glu Ala Ile Ile Ala Cys Ser Leu Tyr Ala
            580                 585                 590         
Val Leu Asn Lys Arg Gly Leu Gly Gly Pro Thr Ser Thr Pro Pro Asn
        595                 600                 605             
Leu Ile Ser Gln Glu Gln Leu Val Arg Lys Ala Ala Ser Leu Cys Tyr
    610                 615                 620                 
Leu Leu Ser Asn Glu Gly Thr Ile Ser Leu Pro Cys Gln Thr Phe Tyr
625                 630                 635                 640 
Gln Val Cys His Glu Thr Val Gly Lys Phe Ile Gln Tyr Gly Ile Leu
                645                 650                 655     
Thr Val Ala Glu His Asp Asp Gln Glu Asp Ile Ser Pro Ser Leu Ala
            660                 665                 670         
Glu Gln Gln Trp Asp Lys Lys Leu Pro Glu Pro Leu Ser Trp Arg Ser
        675                 680                 685             
Asp Glu Glu Asp Glu Asp Ser Asp Phe Gly Glu Glu Gln Arg Asp Cys
    690                 695                 700                 
Tyr Leu Lys Val Ser Gln Ser Lys Glu His Gln Gln Phe Ile Thr Phe
705                 710                 715                 720 
Leu Gln Arg Leu Leu Gly Pro Leu Leu Glu Ala Tyr Ser Ser Ala Ala
                725                 730                 735     
Ile Phe Val His Asn Phe Ser Gly Pro Val Pro Glu Pro Glu Tyr Leu
            740                 745                 750         
Gln Lys Leu His Lys Tyr Leu Ile Thr Arg Thr Glu Arg Asn Val Ala
        755                 760                 765             
Val Tyr Ala Glu Ser Ala Thr Tyr Cys Leu Val Lys Asn Ala Val Lys
    770                 775                 780                 
Met Phe Lys Asp Ile Gly Val Phe Lys Glu Thr Lys Gln Lys Arg Val
785                 790                 795                 800 
Ser Val Leu Glu Leu Ser Ser Thr Phe Leu Pro Gln Cys Asn Arg Gln
                805                 810                 815     
Lys Leu Leu Glu Tyr Ile Leu Ser Phe Val Val Leu Leu Glu Gly Gly
            820                 825                 830         
Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn
        835                 840                 845             
Pro Gly Pro Arg Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu
    850                 855                 860                 
Leu Pro His Pro Ala Phe Leu Leu Ile Pro Cys His Pro Glu Cys Gln
865                 870                 875                 880 
Pro Gln Asn Gly Ser Val Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys
                885                 890                 895     
Val Ala Cys Ala His Tyr Lys Asp Pro Pro Phe Cys Val Ala Arg Cys
            900                 905                 910         
Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe
        915                 920                 925             
Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys Pro Ile Asn Cys Thr His
    930                 935                 940                 
Ser Cys Val Asp Leu Asp Asp Lys Gly Cys Pro Ala Glu Gln Arg Ala
945                 950                 955                 960 
Ser Pro Leu Thr Gly Gly Gly Ser Gly Gly Gly Ser Ser Ile Ile Ser
                965                 970                 975     
Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly
            980                 985                 990         
Ile Leu Ile
        995 


<210> 92
<211> 2979
<212> DNA
<213> Artificial Sequence

<220> 
<223> HIF1a-T2A-Her2t

<400> 92
atggagggcg ccggcggcgc caacgataag aagaagatca gctccgagcg gagaaaggag 60
aagagcaggg acgcagcacg ctctaggcgc agcaaggagt ccgaggtgtt ctacgagctg 120
gcccaccagc tgccactgcc acacaacgtg tctagccacc tggataaggc cagcgtgatg 180
cggctgacca tctcctatct gcgggtgaga aagctgctgg acgccggcga tctggacatc 240
gaggacgata tgaaggccca gatgaattgc ttctacctga aggccctgga cggctttgtg 300
atggtgctga ccgacgatgg cgacatgatc tacatctccg ataacgtgaa taagtatatg 360
ggcctgaccc agtttgagct gacaggccac agcgtgttcg actttaccca cccctgcgat 420
cacgaggaga tgagggagat gctgacacac cgcaacggcc tggtgaagaa gggcaaggag 480
cagaataccc agcggtcttt ctttctgaga atgaagtgta ccctgacaag caggggccgc 540
accatgaaca tcaagtccgc cacatggaag gtgctgcact gcaccggcca catccacgtg 600
tacgatacca actccaatca gccacagtgt ggctataaga agccccctat gacatgcctg 660
gtgctgatct gtgagcctat cccacacccc tctaatatcg agatccccct ggacagcaag 720
accttcctgt ctcggcacag cctggacatg aagtttagct actgcgatga gagaatcaca 780
gagctgatgg gctatgagcc tgaggagctg ctgggcagat ctatctacga gtactatcac 840
gccctggata gcgaccacct gaccaagaca caccacgaca tgttcaccaa gggccaggtg 900
accacaggcc agtacaggat gctggccaag aggggaggat acgtgtgggt ggagacccag 960
gccacagtga tctataacac caagaatagc cagccccagt gcatcgtgtg cgtgaactac 1020
gtggtgtccg gcatcatcca gcacgatctg atcttttctc tgcagcagac cgagtgcgtg 1080
ctgaagcctg tggagtcctc tgacatgaag atgacccagc tgttcacaaa ggtggagtcc 1140
gaggacacaa gctccctgtt tgataagctg aagaaggagc cagacgcact gaccctgctg 1200
gccccagcag caggcgatac aatcatctct ctggacttcg gcagcaatga taccgagaca 1260
gacgatcagc agctggagga ggtgcctctg tataacgatg tgatgctgcc ttctccaaat 1320
gagaagctgc agaacatcaa tctggcaatg agcccactgc ctaccgcaga gacaccaaag 1380
ccactgaggt ctagcgccga cccagccctg aaccaggagg tggccctgaa gctggagcct 1440
aatccagagt ccctggagct gtcttttaca atgccacaga tccaggacca gaccccatcc 1500
ccttctgatg gcagcacacg ccagtcctct ccagagccca acagcccttc cgagtactgc 1560
ttctatgtgg attccgacat ggtgaatgag ttcaagctgg agctggtgga gaagctgttt 1620
gccgaggata ccgaggccaa gaaccccttc agcacccagg atacagacct ggatctggag 1680
atgctggccc cctatatccc tatggacgat gacttccagc tgcggtcctt tgaccagctg 1740
tctcctctgg agagctcctc tgcctcccct gagtctgcca gcccacagtc taccgtgaca 1800
gtgttccagc agacccagat ccaggagcca acagccaatg ccaccacaac cacagccacc 1860
acagatgagc tgaagaccgt gacaaaggac cggatggagg acatcaagat cctgatcgcc 1920
tccccttctc caacccacat ccacaaggag accacatccg ccacaagctc cccttaccgg 1980
gacacccaga gcagaacagc ctccccaaac agagccggca agggcgtgat cgagcagacc 2040
gagaagtctc acccaaggag ccccaatgtg ctgtccgtgg ccctgtctca gcgcaccaca 2100
gtgcccgagg aggagctgaa ccctaagatc ctggccctgc agaatgccca gcggaagaga 2160
aagatggagc acgatggaag cctgttccag gcagtgggaa tcggcaccct gctgcagcag 2220
ccagatgacc acgccgccac cacaagcctg tcctggaaga gggtgaaggg ctgtaagtct 2280
agcgagcaga acggcatgga gcagaagacc atcatcctga tcccatccga cctggcatgc 2340
aggctgctgg gccagagcat ggatgagtcc ggcctgcccc agctgacaag ctacgactgt 2400
gaggtgaacg cccctatcca gggctcccgg aatctgctgc agggcgagga gctgctgaga 2460
gccctggacc aggtgaatct cgagggcggc ggagagggca gaggaagtct tctaacatgc 2520
ggtgacgtgg aggagaatcc cggccctagg atgcttctcc tggtgacaag ccttctgctc 2580
tgtgagttac cacacccagc attcctcctg atcccatgcc accctgagtg tcagccccag 2640
aatggctcag tgacctgttt tggaccggag gctgaccagt gtgtggcctg tgcccactat 2700
aaggaccctc ccttctgcgt ggcccgctgc cccagcggtg tgaaacctga cctctcctac 2760
atgcccatct ggaagtttcc agatgaggag ggcgcatgcc agccttgccc catcaactgc 2820
acccactcct gtgtggacct ggatgacaag ggctgccccg ccgagcagag agccagccct 2880
ctgacgggtg gaggaagcgg aggtggcagc tccatcatct ctgcggtggt tggcattctg 2940
ctggtcgtgg tcttgggggt ggtctttggg atcctcatc                        2979

<210> 93
<211> 993
<212> PRT
<213> Artificial Sequence

<220> 
<223> HIF1a-T2A-Her2t

<400> 93
Met Glu Gly Ala Gly Gly Ala Asn Asp Lys Lys Lys Ile Ser Ser Glu
 1               5                  10                  15      
Arg Arg Lys Glu Lys Ser Arg Asp Ala Ala Arg Ser Arg Arg Ser Lys
            20                  25                  30          
Glu Ser Glu Val Phe Tyr Glu Leu Ala His Gln Leu Pro Leu Pro His
        35                  40                  45              
Asn Val Ser Ser His Leu Asp Lys Ala Ser Val Met Arg Leu Thr Ile
    50                  55                  60                  
Ser Tyr Leu Arg Val Arg Lys Leu Leu Asp Ala Gly Asp Leu Asp Ile
65                  70                  75                  80  
Glu Asp Asp Met Lys Ala Gln Met Asn Cys Phe Tyr Leu Lys Ala Leu
                85                  90                  95      
Asp Gly Phe Val Met Val Leu Thr Asp Asp Gly Asp Met Ile Tyr Ile
            100                 105                 110         
Ser Asp Asn Val Asn Lys Tyr Met Gly Leu Thr Gln Phe Glu Leu Thr
        115                 120                 125             
Gly His Ser Val Phe Asp Phe Thr His Pro Cys Asp His Glu Glu Met
    130                 135                 140                 
Arg Glu Met Leu Thr His Arg Asn Gly Leu Val Lys Lys Gly Lys Glu
145                 150                 155                 160 
Gln Asn Thr Gln Arg Ser Phe Phe Leu Arg Met Lys Cys Thr Leu Thr
                165                 170                 175     
Ser Arg Gly Arg Thr Met Asn Ile Lys Ser Ala Thr Trp Lys Val Leu
            180                 185                 190         
His Cys Thr Gly His Ile His Val Tyr Asp Thr Asn Ser Asn Gln Pro
        195                 200                 205             
Gln Cys Gly Tyr Lys Lys Pro Pro Met Thr Cys Leu Val Leu Ile Cys
    210                 215                 220                 
Glu Pro Ile Pro His Pro Ser Asn Ile Glu Ile Pro Leu Asp Ser Lys
225                 230                 235                 240 
Thr Phe Leu Ser Arg His Ser Leu Asp Met Lys Phe Ser Tyr Cys Asp
                245                 250                 255     
Glu Arg Ile Thr Glu Leu Met Gly Tyr Glu Pro Glu Glu Leu Leu Gly
            260                 265                 270         
Arg Ser Ile Tyr Glu Tyr Tyr His Ala Leu Asp Ser Asp His Leu Thr
        275                 280                 285             
Lys Thr His His Asp Met Phe Thr Lys Gly Gln Val Thr Thr Gly Gln
    290                 295                 300                 
Tyr Arg Met Leu Ala Lys Arg Gly Gly Tyr Val Trp Val Glu Thr Gln
305                 310                 315                 320 
Ala Thr Val Ile Tyr Asn Thr Lys Asn Ser Gln Pro Gln Cys Ile Val
                325                 330                 335     
Cys Val Asn Tyr Val Val Ser Gly Ile Ile Gln His Asp Leu Ile Phe
            340                 345                 350         
Ser Leu Gln Gln Thr Glu Cys Val Leu Lys Pro Val Glu Ser Ser Asp
        355                 360                 365             
Met Lys Met Thr Gln Leu Phe Thr Lys Val Glu Ser Glu Asp Thr Ser
    370                 375                 380                 
Ser Leu Phe Asp Lys Leu Lys Lys Glu Pro Asp Ala Leu Thr Leu Leu
385                 390                 395                 400 
Ala Pro Ala Ala Gly Asp Thr Ile Ile Ser Leu Asp Phe Gly Ser Asn
                405                 410                 415     
Asp Thr Glu Thr Asp Asp Gln Gln Leu Glu Glu Val Pro Leu Tyr Asn
            420                 425                 430         
Asp Val Met Leu Pro Ser Pro Asn Glu Lys Leu Gln Asn Ile Asn Leu
        435                 440                 445             
Ala Met Ser Pro Leu Pro Thr Ala Glu Thr Pro Lys Pro Leu Arg Ser
    450                 455                 460                 
Ser Ala Asp Pro Ala Leu Asn Gln Glu Val Ala Leu Lys Leu Glu Pro
465                 470                 475                 480 
Asn Pro Glu Ser Leu Glu Leu Ser Phe Thr Met Pro Gln Ile Gln Asp
                485                 490                 495     
Gln Thr Pro Ser Pro Ser Asp Gly Ser Thr Arg Gln Ser Ser Pro Glu
            500                 505                 510         
Pro Asn Ser Pro Ser Glu Tyr Cys Phe Tyr Val Asp Ser Asp Met Val
        515                 520                 525             
Asn Glu Phe Lys Leu Glu Leu Val Glu Lys Leu Phe Ala Glu Asp Thr
    530                 535                 540                 
Glu Ala Lys Asn Pro Phe Ser Thr Gln Asp Thr Asp Leu Asp Leu Glu
545                 550                 555                 560 
Met Leu Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe Gln Leu Arg Ser
                565                 570                 575     
Phe Asp Gln Leu Ser Pro Leu Glu Ser Ser Ser Ala Ser Pro Glu Ser
            580                 585                 590         
Ala Ser Pro Gln Ser Thr Val Thr Val Phe Gln Gln Thr Gln Ile Gln
        595                 600                 605             
Glu Pro Thr Ala Asn Ala Thr Thr Thr Thr Ala Thr Thr Asp Glu Leu
    610                 615                 620                 
Lys Thr Val Thr Lys Asp Arg Met Glu Asp Ile Lys Ile Leu Ile Ala
625                 630                 635                 640 
Ser Pro Ser Pro Thr His Ile His Lys Glu Thr Thr Ser Ala Thr Ser
                645                 650                 655     
Ser Pro Tyr Arg Asp Thr Gln Ser Arg Thr Ala Ser Pro Asn Arg Ala
            660                 665                 670         
Gly Lys Gly Val Ile Glu Gln Thr Glu Lys Ser His Pro Arg Ser Pro
        675                 680                 685             
Asn Val Leu Ser Val Ala Leu Ser Gln Arg Thr Thr Val Pro Glu Glu
    690                 695                 700                 
Glu Leu Asn Pro Lys Ile Leu Ala Leu Gln Asn Ala Gln Arg Lys Arg
705                 710                 715                 720 
Lys Met Glu His Asp Gly Ser Leu Phe Gln Ala Val Gly Ile Gly Thr
                725                 730                 735     
Leu Leu Gln Gln Pro Asp Asp His Ala Ala Thr Thr Ser Leu Ser Trp
            740                 745                 750         
Lys Arg Val Lys Gly Cys Lys Ser Ser Glu Gln Asn Gly Met Glu Gln
        755                 760                 765             
Lys Thr Ile Ile Leu Ile Pro Ser Asp Leu Ala Cys Arg Leu Leu Gly
    770                 775                 780                 
Gln Ser Met Asp Glu Ser Gly Leu Pro Gln Leu Thr Ser Tyr Asp Cys
785                 790                 795                 800 
Glu Val Asn Ala Pro Ile Gln Gly Ser Arg Asn Leu Leu Gln Gly Glu
                805                 810                 815     
Glu Leu Leu Arg Ala Leu Asp Gln Val Asn Leu Glu Gly Gly Gly Glu
            820                 825                 830         
Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly
        835                 840                 845             
Pro Arg Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro
    850                 855                 860                 
His Pro Ala Phe Leu Leu Ile Pro Cys His Pro Glu Cys Gln Pro Gln
865                 870                 875                 880 
Asn Gly Ser Val Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala
                885                 890                 895     
Cys Ala His Tyr Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser
            900                 905                 910         
Gly Val Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp
        915                 920                 925             
Glu Glu Gly Ala Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys
    930                 935                 940                 
Val Asp Leu Asp Asp Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro
945                 950                 955                 960 
Leu Thr Gly Gly Gly Ser Gly Gly Gly Ser Ser Ile Ile Ser Ala Val
                965                 970                 975     
Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly Ile Leu
            980                 985                 990         
Ile
    


<210> 94
<211> 1506
<212> DNA
<213> Artificial Sequence

<220> 
<223> MOGAT1-T2A-Her2t

<400> 94
atgaaggtgg agttcgcccc tctgaacatc cagctggccc ggagactgca gaccgtggcc 60
gtgctgcagt gggtgctgaa gtacctgctg ctgggcccaa tgtccatcgg catcacagtg 120
atgctgatca tccacaatta cctgttcctg tatatcccct atctgatgtg gctgtatttt 180
gactggcaca cccctgagag gggcggcagg cgcagctcct ggatcaagaa ctggacactg 240
tggaagcact tcaaggatta ctttccaatc cacctgatca agacccagga cctggatcct 300
tctcacaatt atatcttcgg ctttcaccca cacggaatca tggcagtggg agccttcggc 360
aactttagcg tgaattactc cgacttcaag gatctgttcc ccggctttac cagctatctg 420
cacgtgctgc cactgtggtt ctggtgcccc gtgtttagag agtacgtgat gtccgtgggc 480
ctggtgtctg tgagcaagaa gtccgtgtct tatatggtgt ccaaggaggg cggcggcaac 540
atctctgtga tcgtgctggg aggagcaaag gagtctctgg acgcccaccc tggcaagttc 600
accctgttta tccggcagag aaagggcttt gtgaagatcg ccctgacaca cggagcctct 660
ctggtgccag tggtgagctt cggcgagaac gagctgttta agcagaccga taatcccgag 720
ggcagctgga tcaggacagt gcagaacaag ctgcagaaga tcatgggctt cgcactgcca 780
ctgtttcacg caaggggcgt gttccagtac aattttggcc tgatgaccta tagaaaggcc 840
atccacacag tggtgggcag gcccatccct gtgcgccaga ccctgaatcc cacacaggag 900
cagatcgagg agctgcacca gacctacatg gaggagctgc gcaagctgtt cgaggagcac 960
aagggcaagt atggcatccc tgagcacgag acactggtgc tgaagctcga gggcggcgga 1020
gagggcagag gaagtcttct aacatgcggt gacgtggagg agaatcccgg ccctaggatg 1080
cttctcctgg tgacaagcct tctgctctgt gagttaccac acccagcatt cctcctgatc 1140
ccatgccacc ctgagtgtca gccccagaat ggctcagtga cctgttttgg accggaggct 1200
gaccagtgtg tggcctgtgc ccactataag gaccctccct tctgcgtggc ccgctgcccc 1260
agcggtgtga aacctgacct ctcctacatg cccatctgga agtttccaga tgaggagggc 1320
gcatgccagc cttgccccat caactgcacc cactcctgtg tggacctgga tgacaagggc 1380
tgccccgccg agcagagagc cagccctctg acgggtggag gaagcggagg tggcagctcc 1440
atcatctctg cggtggttgg cattctgctg gtcgtggtct tgggggtggt ctttgggatc 1500
ctcatc                                                            1506

<210> 95
<211> 502
<212> PRT
<213> Artificial Sequence

<220> 
<223> MOGAT1-T2A-Her2t

<400> 95
Met Lys Val Glu Phe Ala Pro Leu Asn Ile Gln Leu Ala Arg Arg Leu
 1               5                  10                  15      
Gln Thr Val Ala Val Leu Gln Trp Val Leu Lys Tyr Leu Leu Leu Gly
            20                  25                  30          
Pro Met Ser Ile Gly Ile Thr Val Met Leu Ile Ile His Asn Tyr Leu
        35                  40                  45              
Phe Leu Tyr Ile Pro Tyr Leu Met Trp Leu Tyr Phe Asp Trp His Thr
    50                  55                  60                  
Pro Glu Arg Gly Gly Arg Arg Ser Ser Trp Ile Lys Asn Trp Thr Leu
65                  70                  75                  80  
Trp Lys His Phe Lys Asp Tyr Phe Pro Ile His Leu Ile Lys Thr Gln
                85                  90                  95      
Asp Leu Asp Pro Ser His Asn Tyr Ile Phe Gly Phe His Pro His Gly
            100                 105                 110         
Ile Met Ala Val Gly Ala Phe Gly Asn Phe Ser Val Asn Tyr Ser Asp
        115                 120                 125             
Phe Lys Asp Leu Phe Pro Gly Phe Thr Ser Tyr Leu His Val Leu Pro
    130                 135                 140                 
Leu Trp Phe Trp Cys Pro Val Phe Arg Glu Tyr Val Met Ser Val Gly
145                 150                 155                 160 
Leu Val Ser Val Ser Lys Lys Ser Val Ser Tyr Met Val Ser Lys Glu
                165                 170                 175     
Gly Gly Gly Asn Ile Ser Val Ile Val Leu Gly Gly Ala Lys Glu Ser
            180                 185                 190         
Leu Asp Ala His Pro Gly Lys Phe Thr Leu Phe Ile Arg Gln Arg Lys
        195                 200                 205             
Gly Phe Val Lys Ile Ala Leu Thr His Gly Ala Ser Leu Val Pro Val
    210                 215                 220                 
Val Ser Phe Gly Glu Asn Glu Leu Phe Lys Gln Thr Asp Asn Pro Glu
225                 230                 235                 240 
Gly Ser Trp Ile Arg Thr Val Gln Asn Lys Leu Gln Lys Ile Met Gly
                245                 250                 255     
Phe Ala Leu Pro Leu Phe His Ala Arg Gly Val Phe Gln Tyr Asn Phe
            260                 265                 270         
Gly Leu Met Thr Tyr Arg Lys Ala Ile His Thr Val Val Gly Arg Pro
        275                 280                 285             
Ile Pro Val Arg Gln Thr Leu Asn Pro Thr Gln Glu Gln Ile Glu Glu
    290                 295                 300                 
Leu His Gln Thr Tyr Met Glu Glu Leu Arg Lys Leu Phe Glu Glu His
305                 310                 315                 320 
Lys Gly Lys Tyr Gly Ile Pro Glu His Glu Thr Leu Val Leu Lys Leu
                325                 330                 335     
Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val
            340                 345                 350         
Glu Glu Asn Pro Gly Pro Arg Met Leu Leu Leu Val Thr Ser Leu Leu
        355                 360                 365             
Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu Ile Pro Cys His Pro
    370                 375                 380                 
Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Phe Gly Pro Glu Ala
385                 390                 395                 400 
Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro Phe Cys Val
                405                 410                 415     
Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met Pro Ile
            420                 425                 430         
Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys Pro Ile Asn
        435                 440                 445             
Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys Gly Cys Pro Ala Glu
    450                 455                 460                 
Gln Arg Ala Ser Pro Leu Thr Gly Gly Gly Ser Gly Gly Gly Ser Ser
465                 470                 475                 480 
Ile Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val
                485                 490                 495     
Val Phe Gly Ile Leu Ile
            500         


<210> 96
<211> 2367
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCK1-T2A-Her2t

<400> 96
atgccccctc agctgcagaa cggcctgaat ctgtccgcca aggtggtgca gggctccctg 60
gactctctgc ctcaggccgt gagggagttt ctggagaaca atgccgagct gtgccagcca 120
gaccacatcc acatctgtga tggctctgag gaggagaacg gccgcctgct gggacagatg 180
gaggaggagg gcatcctgcg gagactgaag aagtacgata attgctggct ggccctgacc 240
gacccaaggg atgtggcacg catcgagagc aagaccgtga tcgtgacaca ggagcagagg 300
gacaccgtgc caatccccaa gacaggcctg tctcagctgg gccgctggat gagcgaggag 360
gatttcgaga aggcctttaa cgcccggttc cctggctgta tgaagggcag aaccatgtac 420
gtgatcccct tcagcatggg acctctggga agcccactgt ccaagatcgg catcgagctg 480
acagactccc catatgtggt ggcctctatg cggatcatga ccagaatggg aacacccgtg 540
ctggaggcag tgggcgatgg cgagttcgtg aagtgcctgc actccgtggg ctgtcctctg 600
ccactgcaga agcccctggt gaacaattgg ccctgcaacc ctgagctgac cctgatcgca 660
cacctgcctg acaggaggga gatcatctct tttggcagcg gctacggcgg caatagcctg 720
ctgggcaaga agtgtttcgc actgaggatg gcctcccgcc tggccaagga ggagggatgg 780
ctggccgagc acatgctgat cctgggcatc accaatcccg agggcgagaa gaagtatctg 840
gctgccgcct ttccttctgc ctgcggcaag acaaacctgg ccatgatgaa tccaagcctg 900
ccaggatgga aggtggagtg cgtgggcgac gacatcgcct ggatgaagtt cgatgcacag 960
ggacacctga gggccatcaa cccagagaat ggcttctttg gcgtggcccc aggcacctct 1020
gtgaagacaa accccaatgc catcaagacc atccagaaga acaccatctt tacaaatgtg 1080
gccgagacaa gcgacggagg cgtgtactgg gagggaatcg atgagcccct ggccagcggc 1140
gtgaccatca catcctggaa gaacaaggag tggagctccg aggacggaga gccatgcgca 1200
caccctaatt ccagattctg cacccccgcc tctcagtgtc ctatcatcga tgcagcatgg 1260
gagtctccag agggagtgcc aatcgagggc atcatctttg gcggccggag acctgcagga 1320
gtgccactgg tgtatgaggc cctgtcctgg cagcacggcg tgttcgtggg agcagcaatg 1380
cggtctgagg caacagctgc cgccgagcac aagggcaaga tcatcatgca cgacccattt 1440
gccatgagac ccttctttgg ctacaacttc ggcaagtatc tggcacactg gctgtccatg 1500
gcacagcacc ctgcagcaaa gctgccaaag atctttcacg tgaattggtt caggaaggat 1560
aaggagggca agtttctgtg gcctggcttc ggcgagaaca gcagggtgct ggagtggatg 1620
ttcaatcgca tcgacggcaa ggcctccacc aagctgacac ccatcggcta catccctaag 1680
gaggatgccc tgaacctgaa gggcctgggc cacatcaata tgatggagct gttttctatc 1740
agcaaggagt tctgggagaa ggaggtggag gacatcgaga agtatctgga ggaccaggtg 1800
aacgccgatc tgccctgtga gatcgagcgg gagatcctgg ccctgaagca gagaatctcc 1860
cagatgctcg agggcggcgg agagggcaga ggaagtcttc taacatgcgg tgacgtggag 1920
gagaatcccg gccctaggat gcttctcctg gtgacaagcc ttctgctctg tgagttacca 1980
cacccagcat tcctcctgat cccatgccac cctgagtgtc agccccagaa tggctcagtg 2040
acctgttttg gaccggaggc tgaccagtgt gtggcctgtg cccactataa ggaccctccc 2100
ttctgcgtgg cccgctgccc cagcggtgtg aaacctgacc tctcctacat gcccatctgg 2160
aagtttccag atgaggaggg cgcatgccag ccttgcccca tcaactgcac ccactcctgt 2220
gtggacctgg atgacaaggg ctgccccgcc gagcagagag ccagccctct gacgggtgga 2280
ggaagcggag gtggcagctc catcatctct gcggtggttg gcattctgct ggtcgtggtc 2340
ttgggggtgg tctttgggat cctcatc                                     2367

<210> 97
<211> 789
<212> PRT
<213> Artificial Sequence

<220> 
<223> PCK1-T2A-Her2t

<400> 97
Met Pro Pro Gln Leu Gln Asn Gly Leu Asn Leu Ser Ala Lys Val Val
 1               5                  10                  15      
Gln Gly Ser Leu Asp Ser Leu Pro Gln Ala Val Arg Glu Phe Leu Glu
            20                  25                  30          
Asn Asn Ala Glu Leu Cys Gln Pro Asp His Ile His Ile Cys Asp Gly
        35                  40                  45              
Ser Glu Glu Glu Asn Gly Arg Leu Leu Gly Gln Met Glu Glu Glu Gly
    50                  55                  60                  
Ile Leu Arg Arg Leu Lys Lys Tyr Asp Asn Cys Trp Leu Ala Leu Thr
65                  70                  75                  80  
Asp Pro Arg Asp Val Ala Arg Ile Glu Ser Lys Thr Val Ile Val Thr
                85                  90                  95      
Gln Glu Gln Arg Asp Thr Val Pro Ile Pro Lys Thr Gly Leu Ser Gln
            100                 105                 110         
Leu Gly Arg Trp Met Ser Glu Glu Asp Phe Glu Lys Ala Phe Asn Ala
        115                 120                 125             
Arg Phe Pro Gly Cys Met Lys Gly Arg Thr Met Tyr Val Ile Pro Phe
    130                 135                 140                 
Ser Met Gly Pro Leu Gly Ser Pro Leu Ser Lys Ile Gly Ile Glu Leu
145                 150                 155                 160 
Thr Asp Ser Pro Tyr Val Val Ala Ser Met Arg Ile Met Thr Arg Met
                165                 170                 175     
Gly Thr Pro Val Leu Glu Ala Val Gly Asp Gly Glu Phe Val Lys Cys
            180                 185                 190         
Leu His Ser Val Gly Cys Pro Leu Pro Leu Gln Lys Pro Leu Val Asn
        195                 200                 205             
Asn Trp Pro Cys Asn Pro Glu Leu Thr Leu Ile Ala His Leu Pro Asp
    210                 215                 220                 
Arg Arg Glu Ile Ile Ser Phe Gly Ser Gly Tyr Gly Gly Asn Ser Leu
225                 230                 235                 240 
Leu Gly Lys Lys Cys Phe Ala Leu Arg Met Ala Ser Arg Leu Ala Lys
                245                 250                 255     
Glu Glu Gly Trp Leu Ala Glu His Met Leu Ile Leu Gly Ile Thr Asn
            260                 265                 270         
Pro Glu Gly Glu Lys Lys Tyr Leu Ala Ala Ala Phe Pro Ser Ala Cys
        275                 280                 285             
Gly Lys Thr Asn Leu Ala Met Met Asn Pro Ser Leu Pro Gly Trp Lys
    290                 295                 300                 
Val Glu Cys Val Gly Asp Asp Ile Ala Trp Met Lys Phe Asp Ala Gln
305                 310                 315                 320 
Gly His Leu Arg Ala Ile Asn Pro Glu Asn Gly Phe Phe Gly Val Ala
                325                 330                 335     
Pro Gly Thr Ser Val Lys Thr Asn Pro Asn Ala Ile Lys Thr Ile Gln
            340                 345                 350         
Lys Asn Thr Ile Phe Thr Asn Val Ala Glu Thr Ser Asp Gly Gly Val
        355                 360                 365             
Tyr Trp Glu Gly Ile Asp Glu Pro Leu Ala Ser Gly Val Thr Ile Thr
    370                 375                 380                 
Ser Trp Lys Asn Lys Glu Trp Ser Ser Glu Asp Gly Glu Pro Cys Ala
385                 390                 395                 400 
His Pro Asn Ser Arg Phe Cys Thr Pro Ala Ser Gln Cys Pro Ile Ile
                405                 410                 415     
Asp Ala Ala Trp Glu Ser Pro Glu Gly Val Pro Ile Glu Gly Ile Ile
            420                 425                 430         
Phe Gly Gly Arg Arg Pro Ala Gly Val Pro Leu Val Tyr Glu Ala Leu
        435                 440                 445             
Ser Trp Gln His Gly Val Phe Val Gly Ala Ala Met Arg Ser Glu Ala
    450                 455                 460                 
Thr Ala Ala Ala Glu His Lys Gly Lys Ile Ile Met His Asp Pro Phe
465                 470                 475                 480 
Ala Met Arg Pro Phe Phe Gly Tyr Asn Phe Gly Lys Tyr Leu Ala His
                485                 490                 495     
Trp Leu Ser Met Ala Gln His Pro Ala Ala Lys Leu Pro Lys Ile Phe
            500                 505                 510         
His Val Asn Trp Phe Arg Lys Asp Lys Glu Gly Lys Phe Leu Trp Pro
        515                 520                 525             
Gly Phe Gly Glu Asn Ser Arg Val Leu Glu Trp Met Phe Asn Arg Ile
    530                 535                 540                 
Asp Gly Lys Ala Ser Thr Lys Leu Thr Pro Ile Gly Tyr Ile Pro Lys
545                 550                 555                 560 
Glu Asp Ala Leu Asn Leu Lys Gly Leu Gly His Ile Asn Met Met Glu
                565                 570                 575     
Leu Phe Ser Ile Ser Lys Glu Phe Trp Glu Lys Glu Val Glu Asp Ile
            580                 585                 590         
Glu Lys Tyr Leu Glu Asp Gln Val Asn Ala Asp Leu Pro Cys Glu Ile
        595                 600                 605             
Glu Arg Glu Ile Leu Ala Leu Lys Gln Arg Ile Ser Gln Met Leu Glu
    610                 615                 620                 
Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu
625                 630                 635                 640 
Glu Asn Pro Gly Pro Arg Met Leu Leu Leu Val Thr Ser Leu Leu Leu
                645                 650                 655     
Cys Glu Leu Pro His Pro Ala Phe Leu Leu Ile Pro Cys His Pro Glu
            660                 665                 670         
Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Phe Gly Pro Glu Ala Asp
        675                 680                 685             
Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro Phe Cys Val Ala
    690                 695                 700                 
Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp
705                 710                 715                 720 
Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys Pro Ile Asn Cys
                725                 730                 735     
Thr His Ser Cys Val Asp Leu Asp Asp Lys Gly Cys Pro Ala Glu Gln
            740                 745                 750         
Arg Ala Ser Pro Leu Thr Gly Gly Gly Ser Gly Gly Gly Ser Ser Ile
        755                 760                 765             
Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val
    770                 775                 780                 
Phe Gly Ile Leu Ile
785                 

