                               SEQUENCE LISTING

<110> GENENTECH, INC.
      F. HOFFMANN-LA ROCHE AG
 
<120> METHODS OF SCREENING FOR MULTISPECIFIC ANTIBODIES

<130> 00B206.0273

<140>
<141>

<150> 62/252,549
<151> 2015-11-08

<160> 88    

<170> PatentIn version 3.5

<210> 1
<211> 992
<212> PRT
<213> Homo sapiens

<400> 1
Phe Ser Gly Asp Gly Arg Ala Ile Trp Ser Lys Asn Pro Asn Phe Thr 
1               5                   10                  15      


Pro Val Asn Glu Ser Gln Leu Phe Leu Tyr Asp Thr Phe Pro Lys Asn 
            20                  25                  30          


Phe Phe Trp Gly Ile Gly Thr Gly Ala Leu Gln Val Glu Gly Ser Trp 
        35                  40                  45              


Lys Lys Asp Gly Lys Gly Pro Ser Ile Trp Asp His Phe Ile His Thr 
    50                  55                  60                  


His Leu Lys Asn Val Ser Ser Thr Asn Gly Ser Ser Asp Ser Tyr Ile 
65                  70                  75                  80  


Phe Leu Glu Lys Asp Leu Ser Ala Leu Asp Phe Ile Gly Val Ser Phe 
                85                  90                  95      


Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro Asp Gly Ile Val 
            100                 105                 110         


Thr Val Ala Asn Ala Lys Gly Leu Gln Tyr Tyr Ser Thr Leu Leu Asp 
        115                 120                 125             


Ala Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr Leu Tyr His Trp 
    130                 135                 140                 


Asp Leu Pro Leu Ala Leu Gln Glu Lys Tyr Gly Gly Trp Lys Asn Asp 
145                 150                 155                 160 


Thr Ile Ile Asp Ile Phe Asn Asp Tyr Ala Thr Tyr Cys Phe Gln Met 
                165                 170                 175     


Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His Asn Pro Tyr Leu 
            180                 185                 190         


Val Ala Trp His Gly Tyr Gly Thr Gly Met His Ala Pro Gly Glu Lys 
        195                 200                 205             


Gly Asn Leu Ala Ala Val Tyr Thr Val Gly His Asn Leu Ile Lys Ala 
    210                 215                 220                 


His Ser Lys Val Trp His Asn Tyr Asn Thr His Phe Arg Pro His Gln 
225                 230                 235                 240 


Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp Ile Glu Pro Asn 
                245                 250                 255     


Arg Ser Glu Asn Thr Met Asp Ile Phe Lys Cys Gln Gln Ser Met Val 
            260                 265                 270         


Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly Asp Gly Asp Tyr 
        275                 280                 285             


Pro Glu Gly Met Arg Lys Lys Leu Phe Ser Val Leu Pro Ile Phe Ser 
    290                 295                 300                 


Glu Ala Glu Lys His Glu Met Arg Gly Thr Ala Asp Phe Phe Ala Phe 
305                 310                 315                 320 


Ser Phe Gly Pro Asn Asn Phe Lys Pro Leu Asn Thr Met Ala Lys Met 
                325                 330                 335     


Gly Gln Asn Val Ser Leu Asn Leu Arg Glu Ala Leu Asn Trp Ile Lys 
            340                 345                 350         


Leu Glu Tyr Asn Asn Pro Arg Ile Leu Ile Ala Glu Asn Gly Trp Phe 
        355                 360                 365             


Thr Asp Ser Arg Val Lys Thr Glu Asp Thr Thr Ala Ile Tyr Met Met 
    370                 375                 380                 


Lys Asn Phe Leu Ser Gln Val Leu Gln Ala Ile Arg Leu Asp Glu Ile 
385                 390                 395                 400 


Arg Val Phe Gly Tyr Thr Ala Trp Ser Leu Leu Asp Gly Phe Glu Trp 
                405                 410                 415     


Gln Asp Ala Tyr Thr Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Asn 
            420                 425                 430         


Ser Lys Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala His Tyr Tyr Lys 
        435                 440                 445             


Gln Ile Ile Arg Glu Asn Gly Phe Ser Leu Lys Glu Ser Thr Pro Asp 
    450                 455                 460                 


Val Gln Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly Val Thr Glu Ser 
465                 470                 475                 480 


Val Leu Lys Pro Glu Ser Val Ala Ser Ser Pro Gln Phe Ser Asp Pro 
                485                 490                 495     


His Leu Tyr Val Trp Asn Ala Thr Gly Asn Arg Leu Leu His Arg Val 
            500                 505                 510         


Glu Gly Val Arg Leu Lys Thr Arg Pro Ala Gln Cys Thr Asp Phe Val 
        515                 520                 525             


Asn Ile Lys Lys Gln Leu Glu Met Leu Ala Arg Met Lys Val Thr His 
    530                 535                 540                 


Tyr Arg Phe Ala Leu Asp Trp Ala Ser Val Leu Pro Thr Gly Asn Leu 
545                 550                 555                 560 


Ser Ala Val Asn Arg Gln Ala Leu Arg Tyr Tyr Arg Cys Val Val Ser 
                565                 570                 575     


Glu Gly Leu Lys Leu Gly Ile Ser Ala Met Val Thr Leu Tyr Tyr Pro 
            580                 585                 590         


Thr His Ala His Leu Gly Leu Pro Glu Pro Leu Leu His Ala Asp Gly 
        595                 600                 605             


Trp Leu Asn Pro Ser Thr Ala Glu Ala Phe Gln Ala Tyr Ala Gly Leu 
    610                 615                 620                 


Cys Phe Gln Glu Leu Gly Asp Leu Val Lys Leu Trp Ile Thr Ile Asn 
625                 630                 635                 640 


Glu Pro Asn Arg Leu Ser Asp Ile Tyr Asn Arg Ser Gly Asn Asp Thr 
                645                 650                 655     


Tyr Gly Ala Ala His Asn Leu Leu Val Ala His Ala Leu Ala Trp Arg 
            660                 665                 670         


Leu Tyr Asp Arg Gln Phe Arg Pro Ser Gln Arg Gly Ala Val Ser Leu 
        675                 680                 685             


Ser Leu His Ala Asp Trp Ala Glu Pro Ala Asn Pro Tyr Ala Asp Ser 
    690                 695                 700                 


His Trp Arg Ala Ala Glu Arg Phe Leu Gln Phe Glu Ile Ala Trp Phe 
705                 710                 715                 720 


Ala Glu Pro Leu Phe Lys Thr Gly Asp Tyr Pro Ala Ala Met Arg Glu 
                725                 730                 735     


Tyr Ile Ala Ser Lys His Arg Arg Gly Leu Ser Ser Ser Ala Leu Pro 
            740                 745                 750         


Arg Leu Thr Glu Ala Glu Arg Arg Leu Leu Lys Gly Thr Val Asp Phe 
        755                 760                 765             


Cys Ala Leu Asn His Phe Thr Thr Arg Phe Val Met His Glu Gln Leu 
    770                 775                 780                 


Ala Gly Ser Arg Tyr Asp Ser Asp Arg Asp Ile Gln Phe Leu Gln Asp 
785                 790                 795                 800 


Ile Thr Arg Leu Ser Ser Pro Thr Arg Leu Ala Val Ile Pro Trp Gly 
                805                 810                 815     


Val Arg Lys Leu Leu Arg Trp Val Arg Arg Asn Tyr Gly Asp Met Asp 
            820                 825                 830         


Ile Tyr Ile Thr Ala Ser Gly Ile Asp Asp Gln Ala Leu Glu Asp Asp 
        835                 840                 845             


Arg Leu Arg Lys Tyr Tyr Leu Gly Lys Tyr Leu Gln Glu Val Leu Lys 
    850                 855                 860                 


Ala Tyr Leu Ile Asp Lys Val Arg Ile Lys Gly Tyr Tyr Ala Phe Lys 
865                 870                 875                 880 


Leu Ala Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe Phe Thr Ser Asp 
                885                 890                 895     


Phe Lys Ala Lys Ser Ser Ile Gln Phe Tyr Asn Lys Val Ile Ser Ser 
            900                 905                 910         


Arg Gly Phe Pro Phe Glu Asn Ser Ser Ser Arg Cys Ser Gln Thr Gln 
        915                 920                 925             


Glu Asn Thr Glu Cys Thr Val Cys Leu Phe Leu Val Gln Lys Lys Pro 
    930                 935                 940                 


Leu Ile Phe Leu Gly Cys Cys Phe Phe Ser Thr Leu Val Leu Leu Leu 
945                 950                 955                 960 


Ser Ile Ala Ile Phe Gln Arg Gln Lys Arg Arg Lys Phe Trp Lys Ala 
                965                 970                 975     


Lys Asn Leu Gln His Ile Pro Leu Lys Lys Gly Lys Arg Val Val Ser 
            980                 985                 990         


<210> 2
<211> 455
<212> PRT
<213> Homo sapiens

<400> 2
Phe Pro Cys Asp Phe Ser Trp Gly Val Thr Glu Ser Val Leu Lys Pro 
1               5                   10                  15      


Glu Ser Val Ala Ser Ser Pro Gln Phe Ser Asp Pro His Leu Tyr Val 
            20                  25                  30          


Trp Asn Ala Thr Gly Asn Arg Leu Leu His Arg Val Glu Gly Val Arg 
        35                  40                  45              


Leu Lys Thr Arg Pro Ala Gln Cys Thr Asp Phe Val Asn Ile Lys Lys 
    50                  55                  60                  


Gln Leu Glu Met Leu Ala Arg Met Lys Val Thr His Tyr Arg Phe Ala 
65                  70                  75                  80  


Leu Asp Trp Ala Ser Val Leu Pro Thr Gly Asn Leu Ser Ala Val Asn 
                85                  90                  95      


Arg Gln Ala Leu Arg Tyr Tyr Arg Cys Val Val Ser Glu Gly Leu Lys 
            100                 105                 110         


Leu Gly Ile Ser Ala Met Val Thr Leu Tyr Tyr Pro Thr His Ala His 
        115                 120                 125             


Leu Gly Leu Pro Glu Pro Leu Leu His Ala Asp Gly Trp Leu Asn Pro 
    130                 135                 140                 


Ser Thr Ala Glu Ala Phe Gln Ala Tyr Ala Gly Leu Cys Phe Gln Glu 
145                 150                 155                 160 


Leu Gly Asp Leu Val Lys Leu Trp Ile Thr Ile Asn Glu Pro Asn Arg 
                165                 170                 175     


Leu Ser Asp Ile Tyr Asn Arg Ser Gly Asn Asp Thr Tyr Gly Ala Ala 
            180                 185                 190         


His Asn Leu Leu Val Ala His Ala Leu Ala Trp Arg Leu Tyr Asp Arg 
        195                 200                 205             


Gln Phe Arg Pro Ser Gln Arg Gly Ala Val Ser Leu Ser Leu His Ala 
    210                 215                 220                 


Asp Trp Ala Glu Pro Ala Asn Pro Tyr Ala Asp Ser His Trp Arg Ala 
225                 230                 235                 240 


Ala Glu Arg Phe Leu Gln Phe Glu Ile Ala Trp Phe Ala Glu Pro Leu 
                245                 250                 255     


Phe Lys Thr Gly Asp Tyr Pro Ala Ala Met Arg Glu Tyr Ile Ala Ser 
            260                 265                 270         


Lys His Arg Arg Gly Leu Ser Ser Ser Ala Leu Pro Arg Leu Thr Glu 
        275                 280                 285             


Ala Glu Arg Arg Leu Leu Lys Gly Thr Val Asp Phe Cys Ala Leu Asn 
    290                 295                 300                 


His Phe Thr Thr Arg Phe Val Met His Glu Gln Leu Ala Gly Ser Arg 
305                 310                 315                 320 


Tyr Asp Ser Asp Arg Asp Ile Gln Phe Leu Gln Asp Ile Thr Arg Leu 
                325                 330                 335     


Ser Ser Pro Thr Arg Leu Ala Val Ile Pro Trp Gly Val Arg Lys Leu 
            340                 345                 350         


Leu Arg Trp Val Arg Arg Asn Tyr Gly Asp Met Asp Ile Tyr Ile Thr 
        355                 360                 365             


Ala Ser Gly Ile Asp Asp Gln Ala Leu Glu Asp Asp Arg Leu Arg Lys 
    370                 375                 380                 


Tyr Tyr Leu Gly Lys Tyr Leu Gln Glu Val Leu Lys Ala Tyr Leu Ile 
385                 390                 395                 400 


Asp Lys Val Arg Ile Lys Gly Tyr Tyr Ala Phe Lys Leu Ala Glu Glu 
                405                 410                 415     


Lys Ser Lys Pro Arg Phe Gly Phe Phe Thr Ser Asp Phe Lys Ala Lys 
            420                 425                 430         


Ser Ser Ile Gln Phe Tyr Asn Lys Val Ile Ser Ser Arg Gly Phe Pro 
        435                 440                 445             


Phe Glu Asn Ser Ser Ser Arg 
    450                 455 


<210> 3
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 3
Asn Tyr Gly Met Asn 
1               5   


<210> 4
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 4
Ser Gly Tyr Tyr Trp Thr 
1               5       


<210> 5
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 5
Asn Tyr Asp Ile Asn 
1               5   


<210> 6
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 6
Ser Gly Tyr Tyr Trp Asn 
1               5       


<210> 7
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 7
Asp Tyr Tyr Ile Asn 
1               5   


<210> 8
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 8
Trp Ile Asp Thr Asp Thr Gly Glu Ala Thr Tyr Thr Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 9
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 9
Tyr Ile Lys Tyr Asp Gly Gly Asn Tyr Tyr Asn Pro Ser Leu Arg Asn 
1               5                   10                  15      


<210> 10
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 10
Trp Ile Tyr Pro Arg Asp Gly Ser Ala Lys Tyr Asn Ala Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 11
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 11
Tyr Ile Arg Tyr Asp Gly Asn Ser Asn Tyr Asn Pro Phe Leu Lys Asn 
1               5                   10                  15      


<210> 12
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 12
Asp Ile Asn Pro Asn Asn Gly Asp Thr Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Ala 
    


<210> 13
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 13
Glu Glu Tyr Gly Leu Phe Gly Phe Pro Tyr 
1               5                   10  


<210> 14
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 14
Gly Asp Tyr Tyr Ala Ser Pro Tyr Gly Ala Met Asp Ser 
1               5                   10              


<210> 15
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 15
Arg Pro Leu Tyr Tyr Gly Ser Thr His Trp Tyr Phe Asp Val 
1               5                   10                  


<210> 16
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 16
Lys Gly Ala Tyr Tyr Ser Ser Phe Asp Ala Leu Asp Tyr 
1               5                   10              


<210> 17
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 17
Arg Phe Tyr Ser Ser Pro Phe Asp Ser 
1               5                   


<210> 18
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 18
Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Ala 
1               5                   10      


<210> 19
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 19
His Ala Ser Gln Asp Ile Asp Val Trp Leu Ser 
1               5                   10      


<210> 20
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 20
Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Met Asn 
1               5                   10                  15  


<210> 21
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 21
Lys Ala Ser Gln Asp Ile Arg Ser Tyr Leu Ser 
1               5                   10      


<210> 22
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 22
Lys Ser Gly Gln Ser Leu Leu Tyr Ser Arg Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 23
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 23
Ala Ala Thr Ser Leu Glu Thr 
1               5           


<210> 24
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 24
Lys Ser Ser Ile Leu His Thr 
1               5           


<210> 25
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 25
Ala Ala Ser Asn Leu Lys Ser 
1               5           


<210> 26
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 26
Arg Ala Asn Arg Leu Val Asp 
1               5           


<210> 27
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 27
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 28
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 28
Gln Gln Tyr Trp Ser Asn Pro Leu Thr 
1               5                   


<210> 29
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 29
Gln Gln Gly Leu Ser Tyr Pro Phe Thr 
1               5                   


<210> 30
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 30
Gln Gln Ser Asn Glu Asp Pro Arg Thr 
1               5                   


<210> 31
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 31
Leu Gln Tyr Asp Glu Phe Pro Leu Thr 
1               5                   


<210> 32
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 32
Gln Gln Tyr Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210> 33
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 33
Asp Ile Gln Met Thr Gln Ser Ser Ser Ser Phe Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Ser Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Ala Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210> 34
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 34
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Ala Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Asp Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Thr Asp Thr Gly Glu Ala Thr Tyr Thr Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Glu Tyr Gly Leu Phe Gly Phe Pro Tyr Trp Gly His Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210> 35
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 35
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asp Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Val Pro Gln Leu Leu Ile 
        35                  40                  45              


Ser Lys Ser Ser Ile Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Leu Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Lys Ile Lys 
            100                 105         


<210> 36
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 36
Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Thr Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Lys Tyr Asp Gly Gly Asn Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Arg Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn His Phe Phe 
65                  70                  75                  80  


Leu Lys Phe Tyr Ser Val Thr Ala Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Ala Ser Pro Tyr Gly Ala Met Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210> 37
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 37
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Lys Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110     


<210> 38
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 38
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Arg Asp Gly Ser Ala Lys Tyr Asn Ala Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Pro Leu Tyr Tyr Gly Ser Thr His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210> 39
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 39
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Ser Cys Lys Ala Ser Gln Asp Ile Arg Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Thr Ser Leu Glu Phe 
65                  70                  75                  80  


Gly Asp Val Gly Leu Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Lys Ile Glu 
            100                 105         


<210> 40
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 40
Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Arg Tyr Asp Gly Asn Ser Asn Tyr Asn Pro Phe Leu 
    50                  55                  60                  


Lys Asn Arg Val Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Lys Gly Ala Tyr Tyr Ser Ser Phe Asp Ala Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210> 41
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 41
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Leu Ser Cys Lys Ser Gly Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Arg Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Ser Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Thr Glu Asp Leu Ala Val Tyr His Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210> 42
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 42
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Gln Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Glu Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Ser Arg Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Ala Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Val Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Phe Tyr Ser Ser Pro Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210> 43
<211> 90
<212> PRT
<213> Homo sapiens

<400> 43
Ile Gln Phe Tyr Asn Lys Val Ile Ser Ser Arg Gly Phe Pro Phe Glu 
1               5                   10                  15      


Asn Ser Ser Ser Arg Cys Ser Gln Thr Gln Glu Asn Thr Glu Cys Thr 
            20                  25                  30          


Val Cys Leu Phe Leu Val Gln Lys Lys Pro Leu Ile Phe Leu Gly Cys 
        35                  40                  45              


Cys Phe Phe Ser Thr Leu Val Leu Leu Leu Ser Ile Ala Ile Phe Gln 
    50                  55                  60                  


Arg Gln Lys Arg Arg Lys Phe Trp Lys Ala Lys Asn Leu Gln His Ile 
65                  70                  75                  80  


Pro Leu Lys Lys Gly Lys Arg Val Val Ser 
                85                  90  


<210> 44
<211> 94
<212> PRT
<213> Homo sapiens

<400> 44
Ala Asp Ser His Trp Arg Ala Ala Glu Arg Phe Leu Gln Phe Glu Ile 
1               5                   10                  15      


Ala Trp Phe Ala Glu Pro Leu Phe Lys Thr Gly Asp Tyr Pro Ala Ala 
            20                  25                  30          


Met Arg Glu Tyr Ile Ala Ser Lys His Arg Arg Gly Leu Ser Ser Ser 
        35                  40                  45              


Ala Leu Pro Arg Leu Thr Glu Ala Glu Arg Arg Leu Leu Lys Gly Thr 
    50                  55                  60                  


Val Asp Phe Cys Ala Leu Asn His Phe Thr Thr Arg Phe Val Met His 
65                  70                  75                  80  


Glu Gln Leu Ala Gly Ser Arg Tyr Asp Ser Asp Arg Asp Ile 
                85                  90                  


<210> 45
<211> 567
<212> PRT
<213> Homo sapiens

<400> 45
Phe Ser Gly Asp Gly Arg Ala Ile Trp Ser Lys Asn Pro Asn Phe Thr 
1               5                   10                  15      


Pro Val Asn Glu Ser Gln Leu Phe Leu Tyr Asp Thr Phe Pro Lys Asn 
            20                  25                  30          


Phe Phe Trp Gly Ile Gly Thr Gly Ala Leu Gln Val Glu Gly Ser Trp 
        35                  40                  45              


Lys Lys Asp Gly Lys Gly Pro Ser Ile Trp Asp His Phe Ile His Thr 
    50                  55                  60                  


His Leu Lys Asn Val Ser Ser Thr Asn Gly Ser Ser Asp Ser Tyr Ile 
65                  70                  75                  80  


Phe Leu Glu Lys Asp Leu Ser Ala Leu Asp Phe Ile Gly Val Ser Phe 
                85                  90                  95      


Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro Asp Gly Ile Val 
            100                 105                 110         


Thr Val Ala Asn Ala Lys Gly Leu Gln Tyr Tyr Ser Thr Leu Leu Asp 
        115                 120                 125             


Ala Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr Leu Tyr His Trp 
    130                 135                 140                 


Asp Leu Pro Leu Ala Leu Gln Glu Lys Tyr Gly Gly Trp Lys Asn Asp 
145                 150                 155                 160 


Thr Ile Ile Asp Ile Phe Asn Asp Tyr Ala Thr Tyr Cys Phe Gln Met 
                165                 170                 175     


Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His Asn Pro Tyr Leu 
            180                 185                 190         


Val Ala Trp His Gly Tyr Gly Thr Gly Met His Ala Pro Gly Glu Lys 
        195                 200                 205             


Gly Asn Leu Ala Ala Val Tyr Thr Val Gly His Asn Leu Ile Lys Ala 
    210                 215                 220                 


His Ser Lys Val Trp His Asn Tyr Asn Thr His Phe Arg Pro His Gln 
225                 230                 235                 240 


Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp Ile Glu Pro Asn 
                245                 250                 255     


Arg Ser Glu Asn Thr Met Asp Ile Phe Lys Cys Gln Gln Ser Met Val 
            260                 265                 270         


Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly Asp Gly Asp Tyr 
        275                 280                 285             


Pro Glu Gly Met Arg Lys Lys Leu Phe Ser Val Leu Pro Ile Phe Ser 
    290                 295                 300                 


Glu Ala Glu Lys His Glu Met Arg Gly Thr Ala Asp Phe Phe Ala Phe 
305                 310                 315                 320 


Ser Phe Gly Pro Asn Asn Phe Lys Pro Leu Asn Thr Met Ala Lys Met 
                325                 330                 335     


Gly Gln Asn Val Ser Leu Asn Leu Arg Glu Ala Leu Asn Trp Ile Lys 
            340                 345                 350         


Leu Glu Tyr Asn Asn Pro Arg Ile Leu Ile Ala Glu Asn Gly Trp Phe 
        355                 360                 365             


Thr Asp Ser Arg Val Lys Thr Glu Asp Thr Thr Ala Ile Tyr Met Met 
    370                 375                 380                 


Lys Asn Phe Leu Ser Gln Val Leu Gln Ala Ile Arg Leu Asp Glu Ile 
385                 390                 395                 400 


Arg Val Phe Gly Tyr Thr Ala Trp Ser Leu Leu Asp Gly Phe Glu Trp 
                405                 410                 415     


Gln Asp Ala Tyr Thr Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Asn 
            420                 425                 430         


Ser Lys Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala His Tyr Tyr Lys 
        435                 440                 445             


Gln Ile Ile Arg Glu Asn Gly Phe Ser Leu Lys Glu Ser Thr Pro Asp 
    450                 455                 460                 


Val Gln Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly Val Thr Glu Ser 
465                 470                 475                 480 


Val Leu Lys Pro Glu Ser Val Ala Ser Ser Pro Gln Phe Ser Asp Pro 
                485                 490                 495     


His Leu Tyr Val Trp Asn Ala Thr Gly Asn Arg Leu Leu His Arg Val 
            500                 505                 510         


Glu Gly Val Arg Leu Lys Thr Arg Pro Ala Gln Cys Thr Asp Phe Val 
        515                 520                 525             


Asn Ile Lys Lys Gln Leu Glu Met Leu Ala Arg Met Lys Val Thr His 
    530                 535                 540                 


Tyr Arg Phe Ala Leu Asp Trp Ala Ser Val Leu Pro Thr Gly Asn Leu 
545                 550                 555                 560 


Ser Ala Val Asn Arg Gln Ala 
                565         


<210> 46
<211> 106
<212> PRT
<213> Homo sapiens

<400> 46
Lys Thr Val Ala Leu Gly Ser Asn Val Glu Phe Met Cys Lys Val Tyr 
1               5                   10                  15      


Ser Asp Pro Gln Pro His Ile Gln Trp Leu Lys His Ile Glu Val Asn 
            20                  25                  30          


Gly Ser Lys Ile Gly Pro Asp Asn Leu Pro Tyr Val Gln Ile Leu Lys 
        35                  40                  45              


Thr Ala Gly Val Asn Thr Thr Asp Lys Glu Met Glu Val Leu His Leu 
    50                  55                  60                  


Arg Asn Val Ser Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
65                  70                  75                  80  


Asn Ser Ile Gly Leu Ser His His Ser Ala Trp Leu Thr Val Leu Glu 
                85                  90                  95      


Ala Leu Glu Glu Arg Pro Ala Val Met Thr 
            100                 105     


<210> 47
<211> 992
<212> PRT
<213> Homo sapiens

<400> 47
Phe Ser Gly Asp Gly Arg Ala Ile Trp Ser Lys Asn Pro Asn Phe Thr 
1               5                   10                  15      


Pro Val Asn Glu Ser Gln Leu Phe Leu Tyr Asp Thr Phe Pro Lys Asn 
            20                  25                  30          


Phe Phe Trp Gly Ile Gly Thr Gly Ala Leu Gln Val Glu Gly Ser Trp 
        35                  40                  45              


Lys Lys Asp Gly Lys Gly Pro Ser Ile Trp Asp His Phe Ile His Thr 
    50                  55                  60                  


His Leu Lys Asn Val Ser Ser Thr Asn Gly Ser Ser Asp Ser Tyr Ile 
65                  70                  75                  80  


Phe Leu Glu Lys Asp Leu Ser Ala Leu Asp Phe Ile Gly Val Ser Phe 
                85                  90                  95      


Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro Asp Gly Ile Val 
            100                 105                 110         


Thr Val Ala Asn Ala Lys Gly Leu Gln Tyr Tyr Ser Thr Leu Leu Asp 
        115                 120                 125             


Ala Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr Leu Tyr His Trp 
    130                 135                 140                 


Asp Leu Pro Leu Ala Leu Gln Glu Lys Tyr Gly Gly Trp Lys Asn Asp 
145                 150                 155                 160 


Thr Ile Ile Asp Ile Phe Asn Asp Tyr Ala Thr Tyr Cys Phe Gln Met 
                165                 170                 175     


Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His Asn Pro Tyr Leu 
            180                 185                 190         


Val Ala Trp His Gly Tyr Gly Thr Gly Met His Ala Pro Gly Glu Lys 
        195                 200                 205             


Gly Asn Leu Ala Ala Val Tyr Thr Val Gly His Asn Leu Ile Lys Ala 
    210                 215                 220                 


His Ser Lys Val Trp His Asn Tyr Asn Thr His Phe Arg Pro His Gln 
225                 230                 235                 240 


Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp Ile Glu Pro Asn 
                245                 250                 255     


Arg Ser Glu Asn Thr Met Asp Ile Phe Lys Cys Gln Gln Ser Met Val 
            260                 265                 270         


Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly Asp Gly Asp Tyr 
        275                 280                 285             


Pro Glu Gly Met Arg Lys Lys Leu Phe Ser Val Leu Pro Ile Phe Ser 
    290                 295                 300                 


Glu Ala Glu Lys His Glu Met Arg Gly Thr Ala Asp Phe Phe Ala Phe 
305                 310                 315                 320 


Ser Phe Gly Pro Asn Asn Phe Lys Pro Leu Asn Thr Met Ala Lys Met 
                325                 330                 335     


Gly Gln Asn Val Ser Leu Asn Leu Arg Glu Ala Leu Asn Trp Ile Lys 
            340                 345                 350         


Leu Glu Tyr Asn Asn Pro Arg Ile Leu Ile Ala Glu Asn Gly Trp Phe 
        355                 360                 365             


Thr Asp Ser Arg Val Lys Thr Glu Asp Thr Thr Ala Ile Tyr Met Met 
    370                 375                 380                 


Lys Asn Phe Leu Ser Gln Val Leu Gln Ala Ile Arg Leu Asp Glu Ile 
385                 390                 395                 400 


Arg Val Phe Gly Tyr Thr Ala Trp Ser Leu Leu Asp Gly Phe Glu Trp 
                405                 410                 415     


Gln Asp Ala Tyr Thr Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Asn 
            420                 425                 430         


Ser Lys Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala His Tyr Tyr Lys 
        435                 440                 445             


Gln Ile Ile Arg Glu Asn Gly Phe Ser Leu Lys Glu Ser Thr Pro Asp 
    450                 455                 460                 


Val Gln Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly Val Thr Glu Ser 
465                 470                 475                 480 


Val Leu Lys Pro Glu Ser Val Ala Ser Ser Pro Gln Phe Ser Asp Pro 
                485                 490                 495     


His Leu Tyr Val Trp Asn Ala Thr Gly Asn Arg Leu Leu His Arg Val 
            500                 505                 510         


Glu Gly Val Arg Leu Lys Thr Arg Pro Ala Gln Cys Thr Asp Phe Val 
        515                 520                 525             


Asn Ile Lys Lys Gln Leu Glu Met Leu Ala Arg Met Lys Val Thr His 
    530                 535                 540                 


Tyr Arg Phe Ala Leu Asp Trp Ala Ser Val Leu Pro Thr Gly Asn Leu 
545                 550                 555                 560 


Ser Ala Val Asn Arg Gln Ala Leu Arg Tyr Tyr Arg Cys Val Val Ser 
                565                 570                 575     


Glu Gly Leu Lys Leu Gly Ile Ser Ala Met Val Thr Leu Tyr Tyr Pro 
            580                 585                 590         


Thr His Ala His Leu Gly Leu Pro Glu Pro Leu Leu His Ala Asp Gly 
        595                 600                 605             


Trp Leu Asn Pro Ser Thr Ala Glu Ala Phe Gln Ala Tyr Ala Gly Leu 
    610                 615                 620                 


Cys Phe Gln Glu Leu Gly Asp Leu Val Lys Leu Trp Ile Thr Ile Asn 
625                 630                 635                 640 


Glu Pro Asn Arg Leu Ser Asp Ile Tyr Asn Arg Ser Gly Asn Asp Thr 
                645                 650                 655     


Tyr Gly Ala Ala His Asn Leu Leu Val Ala His Ala Leu Ala Trp Arg 
            660                 665                 670         


Leu Tyr Asp Arg Gln Phe Arg Pro Ser Gln Arg Gly Ala Val Ser Leu 
        675                 680                 685             


Ser Leu His Ala Asp Trp Ala Glu Pro Ala Asn Pro Tyr Ala Asp Ser 
    690                 695                 700                 


His Trp Arg Ala Ala Glu Arg Phe Leu Gln Phe Glu Ile Ala Trp Phe 
705                 710                 715                 720 


Ala Glu Pro Leu Phe Lys Thr Gly Asp Tyr Pro Ala Ala Met Arg Glu 
                725                 730                 735     


Tyr Ile Ala Ser Lys His Arg Arg Gly Leu Ser Ser Ser Ala Leu Pro 
            740                 745                 750         


Arg Leu Thr Glu Ala Glu Arg Arg Leu Leu Lys Gly Thr Val Asp Phe 
        755                 760                 765             


Cys Ala Leu Asn His Phe Thr Thr Arg Phe Val Met His Glu Gln Leu 
    770                 775                 780                 


Ala Gly Ser Arg Tyr Asp Ser Asp Arg Asp Ile Gln Phe Leu Gln Asp 
785                 790                 795                 800 


Ile Thr Arg Leu Ser Ser Pro Thr Arg Leu Ala Val Ile Pro Trp Gly 
                805                 810                 815     


Val Arg Lys Leu Leu Arg Trp Val Arg Arg Asn Tyr Gly Asp Met Asp 
            820                 825                 830         


Ile Tyr Ile Thr Ala Ser Gly Ile Asp Asp Gln Ala Leu Glu Asp Asp 
        835                 840                 845             


Arg Leu Arg Lys Tyr Tyr Leu Gly Lys Tyr Leu Gln Glu Val Leu Lys 
    850                 855                 860                 


Ala Tyr Leu Ile Asp Lys Val Arg Ile Lys Gly Tyr Tyr Ala Phe Lys 
865                 870                 875                 880 


Leu Ala Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe Phe Thr Ser Asp 
                885                 890                 895     


Phe Lys Ala Lys Ser Ser Ile Gln Phe Tyr Asn Lys Val Ile Ser Ser 
            900                 905                 910         


Arg Gly Phe Pro Phe Glu Asn Ser Ser Ser Arg Cys Ser Gln Thr Gln 
        915                 920                 925             


Glu Asn Thr Glu Cys Thr Val Cys Leu Phe Leu Val Gln Lys Lys Pro 
    930                 935                 940                 


Leu Ile Phe Leu Gly Cys Cys Phe Phe Ser Thr Leu Val Leu Leu Leu 
945                 950                 955                 960 


Ser Ile Ala Ile Phe Gln Arg Gln Lys Arg Arg Lys Phe Trp Lys Ala 
                965                 970                 975     


Lys Asn Leu Gln His Ile Pro Leu Lys Lys Gly Lys Arg Val Val Ser 
            980                 985                 990         


<210> 48
<211> 991
<212> PRT
<213> Rattus sp.

<400> 48
Phe Ser Gly Asp Gly Lys Ala Ile Trp Asp Lys Lys Gln Tyr Val Ser 
1               5                   10                  15      


Pro Val Asn Pro Gly Gln Leu Phe Leu Tyr Asp Thr Phe Pro Lys Asn 
            20                  25                  30          


Phe Ser Trp Gly Val Gly Thr Gly Ala Phe Gln Val Glu Gly Ser Trp 
        35                  40                  45              


Lys Ala Asp Gly Arg Gly Pro Ser Ile Trp Asp Arg Tyr Val Asp Ser 
    50                  55                  60                  


His Leu Arg Gly Val Asn Ser Thr Asp Arg Ser Thr Asp Ser Tyr Val 
65                  70                  75                  80  


Phe Leu Glu Lys Asp Leu Leu Ala Leu Asp Phe Leu Gly Val Ser Phe 
                85                  90                  95      


Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro Asn Gly Thr Val 
            100                 105                 110         


Ala Ala Val Asn Ala Lys Gly Leu Gln Tyr Tyr Arg Ala Leu Leu Asp 
        115                 120                 125             


Ser Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr Leu Tyr His Trp 
    130                 135                 140                 


Asp Leu Pro Leu Thr Leu Gln Glu Glu Tyr Gly Gly Trp Lys Asn Ala 
145                 150                 155                 160 


Thr Met Ile Asp Leu Phe Asn Asp Tyr Ala Thr Tyr Cys Phe Gln Thr 
                165                 170                 175     


Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His Asn Pro Tyr Leu 
            180                 185                 190         


Val Ala Trp His Gly Phe Gly Thr Gly Met His Ala Pro Gly Glu Lys 
        195                 200                 205             


Gly Asn Leu Thr Ala Val Tyr Thr Val Gly His Asn Leu Ile Lys Ala 
    210                 215                 220                 


His Ser Lys Val Trp His Asn Tyr Asp Lys Asn Phe Arg Pro His Gln 
225                 230                 235                 240 


Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp Ile Glu Pro Asn 
                245                 250                 255     


Arg Thr Glu Asn Met Glu Asp Val Ile Asn Cys Gln His Ser Met Ser 
            260                 265                 270         


Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly Asp Gly Asp Tyr 
        275                 280                 285             


Pro Glu Phe Met Lys Thr Ser Ser Val Ile Pro Glu Phe Ser Glu Ala 
    290                 295                 300                 


Glu Lys Glu Glu Val Arg Gly Thr Ala Asp Phe Phe Ala Phe Ser Phe 
305                 310                 315                 320 


Gly Pro Asn Asn Phe Arg Pro Ser Asn Thr Val Val Lys Met Gly Gln 
                325                 330                 335     


Asn Val Ser Leu Asn Leu Arg Gln Val Leu Asn Trp Ile Lys Leu Glu 
            340                 345                 350         


Tyr Asp Asn Pro Arg Ile Leu Ile Ser Glu Asn Gly Trp Phe Thr Asp 
        355                 360                 365             


Ser Tyr Ile Lys Thr Glu Asp Thr Thr Ala Ile Tyr Met Met Lys Asn 
    370                 375                 380                 


Phe Leu Asn Gln Val Leu Gln Ala Ile Lys Phe Asp Glu Ile Gln Val 
385                 390                 395                 400 


Phe Gly Tyr Thr Ala Trp Thr Leu Leu Asp Gly Phe Glu Trp Gln Asp 
                405                 410                 415     


Ala Tyr Thr Thr Arg Arg Gly Leu Phe Tyr Val Asp Phe Asn Ser Glu 
            420                 425                 430         


Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala His Tyr Tyr Lys Gln Ile 
        435                 440                 445             


Ile Gln Asp Asn Gly Phe Pro Leu Gln Glu Ser Thr Pro Asp Met Lys 
    450                 455                 460                 


Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly Val Thr Glu Ser Val Leu 
465                 470                 475                 480 


Lys Pro Glu Phe Thr Val Ser Ser Pro Gln Phe Thr Asp Pro His Leu 
                485                 490                 495     


Tyr Val Trp Asn Val Thr Gly Asn Arg Leu Leu Tyr Arg Val Glu Gly 
            500                 505                 510         


Val Arg Leu Lys Thr Arg Pro Ser Gln Cys Thr Asp Tyr Val Ser Ile 
        515                 520                 525             


Lys Lys Arg Val Glu Met Leu Ala Lys Met Lys Val Thr His Tyr Gln 
    530                 535                 540                 


Phe Ala Leu Asp Trp Thr Ser Ile Leu Pro Thr Gly Asn Leu Ser Lys 
545                 550                 555                 560 


Ile Asn Arg Gln Val Leu Arg Tyr Tyr Arg Cys Val Val Ser Glu Gly 
                565                 570                 575     


Leu Lys Leu Gly Ile Ser Pro Met Val Thr Leu Tyr His Pro Thr His 
            580                 585                 590         


Ser His Leu Gly Leu Pro Met Pro Leu Leu Ser Ser Gly Gly Trp Leu 
        595                 600                 605             


Asn Thr Asn Thr Ala Lys Ala Phe Gln Asp Tyr Ala Gly Leu Cys Phe 
    610                 615                 620                 


Lys Glu Leu Gly Asp Leu Val Lys Leu Trp Ile Thr Ile Asn Glu Pro 
625                 630                 635                 640 


Asn Arg Leu Ser Asp Met Tyr Asn Arg Thr Ser Asn Asp Thr Tyr Arg 
                645                 650                 655     


Ala Ala His Asn Leu Met Ile Ala His Ala Gln Val Trp His Leu Tyr 
            660                 665                 670         


Asp Arg Gln Tyr Arg Pro Val Gln His Gly Ala Val Ser Leu Ser Leu 
        675                 680                 685             


His Ser Asp Trp Ala Glu Pro Ala Asn Pro Tyr Val Glu Ser His Trp 
    690                 695                 700                 


Lys Ala Ala Glu Arg Phe Leu Gln Phe Glu Ile Ala Trp Phe Ala Asp 
705                 710                 715                 720 


Pro Leu Phe Lys Thr Gly Asp Tyr Pro Leu Ala Met Lys Glu Tyr Ile 
                725                 730                 735     


Ala Ser Lys Lys Gln Arg Gly Leu Ser Ser Ser Val Leu Pro Arg Phe 
            740                 745                 750         


Thr Leu Lys Glu Ser Arg Leu Val Lys Gly Thr Ile Asp Phe Tyr Ala 
        755                 760                 765             


Leu Asn His Phe Thr Thr Arg Phe Val Ile His Lys Gln Leu Asn Thr 
    770                 775                 780                 


Asn Cys Ser Val Ala Asp Arg Asp Val Gln Phe Leu Gln Asp Ile Thr 
785                 790                 795                 800 


Arg Leu Ser Ser Pro Ser Arg Leu Ala Val Thr Pro Trp Gly Met Arg 
                805                 810                 815     


Lys Leu Leu Gly Trp Ile Arg Arg Asn Tyr Arg Asp Met Asp Ile Tyr 
            820                 825                 830         


Val Thr Ala Asn Gly Ile Asp Asp Leu Ala Leu Glu Asp Asp Gln Ile 
        835                 840                 845             


Arg Lys Tyr Tyr Leu Glu Lys Tyr Val Gln Glu Ala Leu Lys Ala Tyr 
    850                 855                 860                 


Leu Ile Asp Lys Val Lys Ile Lys Gly Tyr Tyr Ala Phe Lys Leu Thr 
865                 870                 875                 880 


Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe Phe Thr Ser Asp Phe Lys 
                885                 890                 895     


Ala Lys Ser Ser Val Gln Phe Tyr Ser Lys Leu Ile Ser Ser Ser Gly 
            900                 905                 910         


Phe Ser Ser Glu Asn Arg Ser Pro Ala Cys Gly Gln Pro Pro Glu Asp 
        915                 920                 925             


Thr Glu Cys Ala Ile Cys Ser Phe Leu Thr Gln Lys Lys Pro Leu Ile 
    930                 935                 940                 


Phe Phe Gly Cys Cys Phe Ile Ser Thr Leu Ala Ala Leu Leu Ser Ile 
945                 950                 955                 960 


Thr Ile Phe His His Arg Lys Arg Arg Lys Phe Gln Lys Ala Arg Asn 
                965                 970                 975     


Leu Gln Asn Ile Pro Leu Lys Lys Gly His Ser Arg Val Phe Ser 
            980                 985                 990     


<210> 49
<211> 993
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 49
Phe Ser Gly Asp Gly Arg Ala Ile Trp Ser Lys Asn Pro Asn Phe Thr 
1               5                   10                  15      


Pro Val Asn Glu Ser Gln Leu Phe Leu Tyr Asp Thr Phe Pro Lys Asn 
            20                  25                  30          


Phe Phe Trp Gly Ile Gly Thr Gly Ala Leu Gln Val Glu Gly Ser Trp 
        35                  40                  45              


Lys Lys Asp Gly Lys Gly Pro Ser Ile Trp Asp His Phe Ile His Thr 
    50                  55                  60                  


His Leu Lys Asn Val Ser Ser Thr Asn Gly Ser Ser Asp Ser Tyr Ile 
65                  70                  75                  80  


Phe Leu Glu Lys Asp Leu Ser Ala Leu Asp Phe Ile Gly Val Ser Phe 
                85                  90                  95      


Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro Asp Gly Ile Val 
            100                 105                 110         


Thr Val Ala Asn Ala Lys Gly Leu Gln Tyr Tyr Ser Thr Leu Leu Asp 
        115                 120                 125             


Ala Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr Leu Tyr His Trp 
    130                 135                 140                 


Asp Leu Pro Leu Ala Leu Gln Glu Lys Tyr Gly Gly Trp Lys Asn Asp 
145                 150                 155                 160 


Thr Ile Ile Asp Ile Phe Asn Asp Tyr Ala Thr Tyr Cys Phe Gln Met 
                165                 170                 175     


Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His Asn Pro Tyr Leu 
            180                 185                 190         


Val Ala Trp His Gly Tyr Gly Thr Gly Met His Ala Pro Gly Glu Lys 
        195                 200                 205             


Gly Asn Leu Ala Ala Val Tyr Thr Val Gly His Asn Leu Ile Lys Ala 
    210                 215                 220                 


His Ser Lys Val Trp His Asn Tyr Asn Thr His Phe Arg Pro His Gln 
225                 230                 235                 240 


Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp Ile Glu Pro Asn 
                245                 250                 255     


Arg Ser Glu Asn Thr Met Asp Ile Phe Lys Cys Gln Gln Ser Met Val 
            260                 265                 270         


Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly Asp Gly Asp Tyr 
        275                 280                 285             


Pro Glu Gly Met Arg Lys Lys Leu Phe Ser Val Leu Pro Ile Phe Ser 
    290                 295                 300                 


Glu Ala Glu Lys His Glu Met Arg Gly Thr Ala Asp Phe Phe Ala Phe 
305                 310                 315                 320 


Ser Phe Gly Pro Asn Asn Phe Lys Pro Leu Asn Thr Met Ala Lys Met 
                325                 330                 335     


Gly Gln Asn Val Ser Leu Asn Leu Arg Glu Ala Leu Asn Trp Ile Lys 
            340                 345                 350         


Leu Glu Tyr Asn Asn Pro Arg Ile Leu Ile Ala Glu Asn Gly Trp Phe 
        355                 360                 365             


Thr Asp Ser Arg Val Lys Thr Glu Asp Thr Thr Ala Ile Tyr Met Met 
    370                 375                 380                 


Lys Asn Phe Leu Ser Gln Val Leu Gln Ala Ile Arg Leu Asp Glu Ile 
385                 390                 395                 400 


Arg Val Phe Gly Tyr Thr Ala Trp Ser Leu Leu Asp Gly Phe Glu Trp 
                405                 410                 415     


Gln Asp Ala Tyr Thr Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Asn 
            420                 425                 430         


Ser Lys Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala His Tyr Tyr Lys 
        435                 440                 445             


Gln Ile Ile Arg Glu Asn Gly Phe Ser Leu Lys Glu Ser Thr Pro Asp 
    450                 455                 460                 


Val Gln Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly Val Thr Glu Ser 
465                 470                 475                 480 


Val Leu Lys Pro Glu Ser Val Ala Ser Ser Pro Gln Phe Ser Asp Pro 
                485                 490                 495     


His Leu Tyr Val Trp Asn Ala Thr Gly Asn Arg Leu Leu His Arg Val 
            500                 505                 510         


Glu Gly Val Arg Leu Lys Thr Arg Pro Ala Gln Cys Thr Asp Phe Val 
        515                 520                 525             


Asn Ile Lys Lys Gln Leu Glu Met Leu Ala Arg Met Lys Val Thr His 
    530                 535                 540                 


Tyr Arg Phe Ala Leu Asp Trp Ala Ser Val Leu Pro Thr Gly Asn Leu 
545                 550                 555                 560 


Ser Ala Val Asn Arg Gln Ala Leu Arg Tyr Tyr Arg Cys Val Val Ser 
                565                 570                 575     


Glu Gly Leu Lys Leu Gly Ile Ser Ala Met Val Thr Leu Tyr His Pro 
            580                 585                 590         


Thr His Ser His Leu Gly Leu Pro Met Pro Leu Leu Ser Ser Gly Gly 
        595                 600                 605             


Trp Leu Asn Thr Asn Thr Ala Lys Ala Phe Gln Asp Tyr Ala Gly Leu 
    610                 615                 620                 


Cys Phe Lys Glu Leu Gly Asp Leu Val Lys Leu Trp Ile Thr Ile Asn 
625                 630                 635                 640 


Glu Pro Asn Arg Leu Ser Asp Met Tyr Asn Arg Thr Ser Asn Asp Thr 
                645                 650                 655     


Tyr Arg Ala Ala His Asn Leu Met Ile Ala His Ala Gln Val Trp His 
            660                 665                 670         


Leu Tyr Asp Arg Gln Tyr Arg Pro Val Gln His Gly Ala Val Ser Leu 
        675                 680                 685             


Ser Leu His Ser Asp Trp Ala Glu Pro Ala Asn Pro Tyr Val Glu Ser 
    690                 695                 700                 


His Trp Lys Ala Ala Glu Arg Phe Leu Gln Phe Glu Ile Ala Trp Phe 
705                 710                 715                 720 


Ala Asp Pro Leu Phe Lys Thr Gly Asp Tyr Pro Leu Ala Met Lys Glu 
                725                 730                 735     


Tyr Ile Ala Ser Lys Lys Gln Arg Gly Leu Ser Ser Ser Val Leu Pro 
            740                 745                 750         


Arg Phe Thr Leu Lys Glu Ser Arg Leu Val Lys Gly Thr Ile Asp Phe 
        755                 760                 765             


Tyr Ala Leu Asn His Phe Thr Thr Arg Phe Val Ile His Lys Gln Leu 
    770                 775                 780                 


Asn Thr Asn Cys Ser Val Ala Asp Arg Asp Val Gln Phe Leu Gln Asp 
785                 790                 795                 800 


Ile Thr Arg Leu Ser Ser Pro Ser Arg Leu Ala Val Thr Pro Trp Gly 
                805                 810                 815     


Met Arg Lys Leu Leu Gly Trp Ile Arg Arg Asn Tyr Arg Asp Met Asp 
            820                 825                 830         


Ile Tyr Val Thr Ala Asn Gly Ile Asp Asp Leu Ala Leu Glu Asp Asp 
        835                 840                 845             


Gln Ile Arg Lys Tyr Tyr Leu Glu Lys Tyr Val Gln Glu Ala Leu Lys 
    850                 855                 860                 


Ala Tyr Leu Ile Asp Lys Val Lys Ile Lys Gly Tyr Tyr Ala Phe Lys 
865                 870                 875                 880 


Leu Thr Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe Phe Thr Ser Asp 
                885                 890                 895     


Phe Lys Ala Lys Ser Ser Val Gln Phe Tyr Ser Lys Leu Ile Ser Ser 
            900                 905                 910         


Ser Gly Phe Ser Ser Glu Asn Arg Ser Pro Ala Cys Gly Gln Pro Pro 
        915                 920                 925             


Glu Asp Thr Glu Cys Ala Ile Cys Ser Phe Leu Thr Gln Lys Lys Pro 
    930                 935                 940                 


Leu Ile Phe Phe Gly Cys Cys Phe Ile Ser Thr Leu Ala Ala Leu Leu 
945                 950                 955                 960 


Ser Ile Thr Ile Phe His His Arg Lys Arg Arg Lys Phe Gln Lys Ala 
                965                 970                 975     


Arg Asn Leu Gln Asn Ile Pro Leu Lys Lys Gly His Ser Arg Val Phe 
            980                 985                 990         


Ser 
    


<210> 50
<211> 993
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 50
Phe Ser Gly Asp Gly Arg Ala Ile Trp Ser Lys Asn Pro Asn Phe Thr 
1               5                   10                  15      


Pro Val Asn Glu Ser Gln Leu Phe Leu Tyr Asp Thr Phe Pro Lys Asn 
            20                  25                  30          


Phe Phe Trp Gly Ile Gly Thr Gly Ala Leu Gln Val Glu Gly Ser Trp 
        35                  40                  45              


Lys Lys Asp Gly Lys Gly Pro Ser Ile Trp Asp His Phe Ile His Thr 
    50                  55                  60                  


His Leu Lys Asn Val Ser Ser Thr Asn Gly Ser Ser Asp Ser Tyr Ile 
65                  70                  75                  80  


Phe Leu Glu Lys Asp Leu Ser Ala Leu Asp Phe Ile Gly Val Ser Phe 
                85                  90                  95      


Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro Asp Gly Ile Val 
            100                 105                 110         


Thr Val Ala Asn Ala Lys Gly Leu Gln Tyr Tyr Ser Thr Leu Leu Asp 
        115                 120                 125             


Ala Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr Leu Tyr His Trp 
    130                 135                 140                 


Asp Leu Pro Leu Ala Leu Gln Glu Lys Tyr Gly Gly Trp Lys Asn Asp 
145                 150                 155                 160 


Thr Ile Ile Asp Ile Phe Asn Asp Tyr Ala Thr Tyr Cys Phe Gln Met 
                165                 170                 175     


Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His Asn Pro Tyr Leu 
            180                 185                 190         


Val Ala Trp His Gly Tyr Gly Thr Gly Met His Ala Pro Gly Glu Lys 
        195                 200                 205             


Gly Asn Leu Ala Ala Val Tyr Thr Val Gly His Asn Leu Ile Lys Ala 
    210                 215                 220                 


His Ser Lys Val Trp His Asn Tyr Asn Thr His Phe Arg Pro His Gln 
225                 230                 235                 240 


Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp Ile Glu Pro Asn 
                245                 250                 255     


Arg Ser Glu Asn Thr Met Asp Ile Phe Lys Cys Gln Gln Ser Met Val 
            260                 265                 270         


Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly Asp Gly Asp Tyr 
        275                 280                 285             


Pro Glu Gly Met Arg Lys Lys Leu Phe Ser Val Leu Pro Ile Phe Ser 
    290                 295                 300                 


Glu Ala Glu Lys His Glu Met Arg Gly Thr Ala Asp Phe Phe Ala Phe 
305                 310                 315                 320 


Ser Phe Gly Pro Asn Asn Phe Lys Pro Leu Asn Thr Met Ala Lys Met 
                325                 330                 335     


Gly Gln Asn Val Ser Leu Asn Leu Arg Glu Ala Leu Asn Trp Ile Lys 
            340                 345                 350         


Leu Glu Tyr Asn Asn Pro Arg Ile Leu Ile Ala Glu Asn Gly Trp Phe 
        355                 360                 365             


Thr Asp Ser Arg Val Lys Thr Glu Asp Thr Thr Ala Ile Tyr Met Met 
    370                 375                 380                 


Lys Asn Phe Leu Ser Gln Val Leu Gln Ala Ile Arg Leu Asp Glu Ile 
385                 390                 395                 400 


Arg Val Phe Gly Tyr Thr Ala Trp Ser Leu Leu Asp Gly Phe Glu Trp 
                405                 410                 415     


Gln Asp Ala Tyr Thr Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Asn 
            420                 425                 430         


Ser Lys Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala His Tyr Tyr Lys 
        435                 440                 445             


Gln Ile Ile Arg Glu Asn Gly Phe Ser Leu Lys Glu Ser Thr Pro Asp 
    450                 455                 460                 


Val Gln Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly Val Thr Glu Ser 
465                 470                 475                 480 


Val Leu Lys Pro Glu Ser Val Ala Ser Ser Pro Gln Phe Ser Asp Pro 
                485                 490                 495     


His Leu Tyr Val Trp Asn Ala Thr Gly Asn Arg Leu Leu His Arg Val 
            500                 505                 510         


Glu Gly Val Arg Leu Lys Thr Arg Pro Ala Gln Cys Thr Asp Phe Val 
        515                 520                 525             


Asn Ile Lys Lys Gln Leu Glu Met Leu Ala Arg Met Lys Val Thr His 
    530                 535                 540                 


Tyr Arg Phe Ala Leu Asp Trp Ala Ser Val Leu Pro Thr Gly Asn Leu 
545                 550                 555                 560 


Ser Ala Val Asn Arg Gln Ala Leu Arg Tyr Tyr Arg Cys Val Val Ser 
                565                 570                 575     


Glu Gly Leu Lys Leu Gly Ile Ser Ala Met Val Thr Leu Tyr Tyr Pro 
            580                 585                 590         


Thr His Ala His Leu Gly Leu Pro Glu Pro Leu Leu His Ala Asp Gly 
        595                 600                 605             


Trp Leu Asn Pro Ser Thr Ala Glu Ala Phe Gln Ala Tyr Ala Gly Leu 
    610                 615                 620                 


Cys Phe Gln Glu Leu Gly Asp Leu Val Lys Leu Trp Ile Thr Ile Asn 
625                 630                 635                 640 


Glu Pro Asn Arg Leu Ser Asp Ile Tyr Asn Arg Ser Gly Asn Asp Thr 
                645                 650                 655     


Tyr Gly Ala Ala His Asn Leu Leu Val Ala His Ala Leu Ala Trp Arg 
            660                 665                 670         


Leu Tyr Asp Arg Gln Phe Arg Pro Ser Gln Arg Gly Ala Val Ser Leu 
        675                 680                 685             


Ser Leu His Ala Asp Trp Ala Glu Pro Ala Asn Pro Tyr Val Glu Ser 
    690                 695                 700                 


His Trp Lys Ala Ala Glu Arg Phe Leu Gln Phe Glu Ile Ala Trp Phe 
705                 710                 715                 720 


Ala Asp Pro Leu Phe Lys Thr Gly Asp Tyr Pro Leu Ala Met Lys Glu 
                725                 730                 735     


Tyr Ile Ala Ser Lys Lys Gln Arg Gly Leu Ser Ser Ser Val Leu Pro 
            740                 745                 750         


Arg Phe Thr Leu Lys Glu Ser Arg Leu Val Lys Gly Thr Ile Asp Phe 
        755                 760                 765             


Tyr Ala Leu Asn His Phe Thr Thr Arg Phe Val Ile His Lys Gln Leu 
    770                 775                 780                 


Asn Thr Asn Cys Ser Val Ala Asp Arg Asp Val Gln Phe Leu Gln Asp 
785                 790                 795                 800 


Ile Thr Arg Leu Ser Ser Pro Ser Arg Leu Ala Val Thr Pro Trp Gly 
                805                 810                 815     


Met Arg Lys Leu Leu Gly Trp Ile Arg Arg Asn Tyr Arg Asp Met Asp 
            820                 825                 830         


Ile Tyr Val Thr Ala Asn Gly Ile Asp Asp Leu Ala Leu Glu Asp Asp 
        835                 840                 845             


Gln Ile Arg Lys Tyr Tyr Leu Glu Lys Tyr Val Gln Glu Ala Leu Lys 
    850                 855                 860                 


Ala Tyr Leu Ile Asp Lys Val Lys Ile Lys Gly Tyr Tyr Ala Phe Lys 
865                 870                 875                 880 


Leu Thr Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe Phe Thr Ser Asp 
                885                 890                 895     


Phe Lys Ala Lys Ser Ser Val Gln Phe Tyr Ser Lys Leu Ile Ser Ser 
            900                 905                 910         


Ser Gly Phe Ser Ser Glu Asn Arg Ser Pro Ala Cys Gly Gln Pro Pro 
        915                 920                 925             


Glu Asp Thr Glu Cys Ala Ile Cys Ser Phe Leu Thr Gln Lys Lys Pro 
    930                 935                 940                 


Leu Ile Phe Phe Gly Cys Cys Phe Ile Ser Thr Leu Ala Ala Leu Leu 
945                 950                 955                 960 


Ser Ile Thr Ile Phe His His Arg Lys Arg Arg Lys Phe Gln Lys Ala 
                965                 970                 975     


Arg Asn Leu Gln Asn Ile Pro Leu Lys Lys Gly His Ser Arg Val Phe 
            980                 985                 990         


Ser 
    


<210> 51
<211> 993
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 51
Phe Ser Gly Asp Gly Arg Ala Ile Trp Ser Lys Asn Pro Asn Phe Thr 
1               5                   10                  15      


Pro Val Asn Glu Ser Gln Leu Phe Leu Tyr Asp Thr Phe Pro Lys Asn 
            20                  25                  30          


Phe Phe Trp Gly Ile Gly Thr Gly Ala Leu Gln Val Glu Gly Ser Trp 
        35                  40                  45              


Lys Lys Asp Gly Lys Gly Pro Ser Ile Trp Asp His Phe Ile His Thr 
    50                  55                  60                  


His Leu Lys Asn Val Ser Ser Thr Asn Gly Ser Ser Asp Ser Tyr Ile 
65                  70                  75                  80  


Phe Leu Glu Lys Asp Leu Ser Ala Leu Asp Phe Ile Gly Val Ser Phe 
                85                  90                  95      


Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro Asp Gly Ile Val 
            100                 105                 110         


Thr Val Ala Asn Ala Lys Gly Leu Gln Tyr Tyr Ser Thr Leu Leu Asp 
        115                 120                 125             


Ala Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr Leu Tyr His Trp 
    130                 135                 140                 


Asp Leu Pro Leu Ala Leu Gln Glu Lys Tyr Gly Gly Trp Lys Asn Asp 
145                 150                 155                 160 


Thr Ile Ile Asp Ile Phe Asn Asp Tyr Ala Thr Tyr Cys Phe Gln Met 
                165                 170                 175     


Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His Asn Pro Tyr Leu 
            180                 185                 190         


Val Ala Trp His Gly Tyr Gly Thr Gly Met His Ala Pro Gly Glu Lys 
        195                 200                 205             


Gly Asn Leu Ala Ala Val Tyr Thr Val Gly His Asn Leu Ile Lys Ala 
    210                 215                 220                 


His Ser Lys Val Trp His Asn Tyr Asn Thr His Phe Arg Pro His Gln 
225                 230                 235                 240 


Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp Ile Glu Pro Asn 
                245                 250                 255     


Arg Ser Glu Asn Thr Met Asp Ile Phe Lys Cys Gln Gln Ser Met Val 
            260                 265                 270         


Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly Asp Gly Asp Tyr 
        275                 280                 285             


Pro Glu Gly Met Arg Lys Lys Leu Phe Ser Val Leu Pro Ile Phe Ser 
    290                 295                 300                 


Glu Ala Glu Lys His Glu Met Arg Gly Thr Ala Asp Phe Phe Ala Phe 
305                 310                 315                 320 


Ser Phe Gly Pro Asn Asn Phe Lys Pro Leu Asn Thr Met Ala Lys Met 
                325                 330                 335     


Gly Gln Asn Val Ser Leu Asn Leu Arg Glu Ala Leu Asn Trp Ile Lys 
            340                 345                 350         


Leu Glu Tyr Asn Asn Pro Arg Ile Leu Ile Ala Glu Asn Gly Trp Phe 
        355                 360                 365             


Thr Asp Ser Arg Val Lys Thr Glu Asp Thr Thr Ala Ile Tyr Met Met 
    370                 375                 380                 


Lys Asn Phe Leu Ser Gln Val Leu Gln Ala Ile Arg Leu Asp Glu Ile 
385                 390                 395                 400 


Arg Val Phe Gly Tyr Thr Ala Trp Ser Leu Leu Asp Gly Phe Glu Trp 
                405                 410                 415     


Gln Asp Ala Tyr Thr Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Asn 
            420                 425                 430         


Ser Lys Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala His Tyr Tyr Lys 
        435                 440                 445             


Gln Ile Ile Arg Glu Asn Gly Phe Ser Leu Lys Glu Ser Thr Pro Asp 
    450                 455                 460                 


Val Gln Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly Val Thr Glu Ser 
465                 470                 475                 480 


Val Leu Lys Pro Glu Ser Val Ala Ser Ser Pro Gln Phe Ser Asp Pro 
                485                 490                 495     


His Leu Tyr Val Trp Asn Ala Thr Gly Asn Arg Leu Leu His Arg Val 
            500                 505                 510         


Glu Gly Val Arg Leu Lys Thr Arg Pro Ala Gln Cys Thr Asp Phe Val 
        515                 520                 525             


Asn Ile Lys Lys Gln Leu Glu Met Leu Ala Arg Met Lys Val Thr His 
    530                 535                 540                 


Tyr Arg Phe Ala Leu Asp Trp Ala Ser Val Leu Pro Thr Gly Asn Leu 
545                 550                 555                 560 


Ser Ala Val Asn Arg Gln Ala Leu Arg Tyr Tyr Arg Cys Val Val Ser 
                565                 570                 575     


Glu Gly Leu Lys Leu Gly Ile Ser Ala Met Val Thr Leu Tyr Tyr Pro 
            580                 585                 590         


Thr His Ala His Leu Gly Leu Pro Glu Pro Leu Leu His Ala Asp Gly 
        595                 600                 605             


Trp Leu Asn Pro Ser Thr Ala Glu Ala Phe Gln Ala Tyr Ala Gly Leu 
    610                 615                 620                 


Cys Phe Gln Glu Leu Gly Asp Leu Val Lys Leu Trp Ile Thr Ile Asn 
625                 630                 635                 640 


Glu Pro Asn Arg Leu Ser Asp Ile Tyr Asn Arg Ser Gly Asn Asp Thr 
                645                 650                 655     


Tyr Gly Ala Ala His Asn Leu Leu Val Ala His Ala Leu Ala Trp Arg 
            660                 665                 670         


Leu Tyr Asp Arg Gln Phe Arg Pro Ser Gln Arg Gly Ala Val Ser Leu 
        675                 680                 685             


Ser Leu His Ala Asp Trp Ala Glu Pro Ala Asn Pro Tyr Ala Asp Ser 
    690                 695                 700                 


His Trp Arg Ala Ala Glu Arg Phe Leu Gln Phe Glu Ile Ala Trp Phe 
705                 710                 715                 720 


Ala Glu Pro Leu Phe Lys Thr Gly Asp Tyr Pro Ala Ala Met Arg Glu 
                725                 730                 735     


Tyr Ile Ala Ser Lys His Arg Arg Gly Leu Ser Ser Ser Ala Leu Pro 
            740                 745                 750         


Arg Leu Thr Glu Ala Glu Arg Arg Leu Leu Lys Gly Thr Val Asp Phe 
        755                 760                 765             


Cys Ala Leu Asn His Phe Thr Thr Arg Phe Val Met His Glu Gln Leu 
    770                 775                 780                 


Ala Gly Ser Arg Tyr Asp Ser Asp Arg Asp Ile Gln Phe Leu Gln Asp 
785                 790                 795                 800 


Ile Thr Arg Leu Ser Ser Pro Ser Arg Leu Ala Val Thr Pro Trp Gly 
                805                 810                 815     


Met Arg Lys Leu Leu Gly Trp Ile Arg Arg Asn Tyr Arg Asp Met Asp 
            820                 825                 830         


Ile Tyr Val Thr Ala Asn Gly Ile Asp Asp Leu Ala Leu Glu Asp Asp 
        835                 840                 845             


Gln Ile Arg Lys Tyr Tyr Leu Glu Lys Tyr Val Gln Glu Ala Leu Lys 
    850                 855                 860                 


Ala Tyr Leu Ile Asp Lys Val Lys Ile Lys Gly Tyr Tyr Ala Phe Lys 
865                 870                 875                 880 


Leu Thr Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe Phe Thr Ser Asp 
                885                 890                 895     


Phe Lys Ala Lys Ser Ser Val Gln Phe Tyr Ser Lys Leu Ile Ser Ser 
            900                 905                 910         


Ser Gly Phe Ser Ser Glu Asn Arg Ser Pro Ala Cys Gly Gln Pro Pro 
        915                 920                 925             


Glu Asp Thr Glu Cys Ala Ile Cys Ser Phe Leu Thr Gln Lys Lys Pro 
    930                 935                 940                 


Leu Ile Phe Phe Gly Cys Cys Phe Ile Ser Thr Leu Ala Ala Leu Leu 
945                 950                 955                 960 


Ser Ile Thr Ile Phe His His Arg Lys Arg Arg Lys Phe Gln Lys Ala 
                965                 970                 975     


Arg Asn Leu Gln Asn Ile Pro Leu Lys Lys Gly His Ser Arg Val Phe 
            980                 985                 990         


Ser 
    


<210> 52
<211> 990
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 52
Phe Ser Gly Asp Gly Lys Ala Ile Trp Asp Lys Lys Gln Tyr Val Ser 
1               5                   10                  15      


Pro Val Asn Pro Gly Gln Leu Phe Leu Tyr Asp Thr Phe Pro Lys Asn 
            20                  25                  30          


Phe Ser Trp Gly Val Gly Thr Gly Ala Phe Gln Val Glu Gly Ser Trp 
        35                  40                  45              


Lys Ala Asp Gly Arg Gly Pro Ser Ile Trp Asp Arg Tyr Val Asp Ser 
    50                  55                  60                  


His Leu Arg Gly Val Asn Ser Thr Asp Arg Ser Thr Asp Ser Tyr Val 
65                  70                  75                  80  


Phe Leu Glu Lys Asp Leu Leu Ala Leu Asp Phe Leu Gly Val Ser Phe 
                85                  90                  95      


Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro Asn Gly Thr Val 
            100                 105                 110         


Ala Ala Val Asn Ala Lys Gly Leu Gln Tyr Tyr Arg Ala Leu Leu Asp 
        115                 120                 125             


Ser Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr Leu Tyr His Trp 
    130                 135                 140                 


Asp Leu Pro Leu Thr Leu Gln Glu Glu Tyr Gly Gly Trp Lys Asn Ala 
145                 150                 155                 160 


Thr Met Ile Asp Leu Phe Asn Asp Tyr Ala Thr Tyr Cys Phe Gln Thr 
                165                 170                 175     


Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His Asn Pro Tyr Leu 
            180                 185                 190         


Val Ala Trp His Gly Phe Gly Thr Gly Met His Ala Pro Gly Glu Lys 
        195                 200                 205             


Gly Asn Leu Thr Ala Val Tyr Thr Val Gly His Asn Leu Ile Lys Ala 
    210                 215                 220                 


His Ser Lys Val Trp His Asn Tyr Asp Lys Asn Phe Arg Pro His Gln 
225                 230                 235                 240 


Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp Ile Glu Pro Asn 
                245                 250                 255     


Arg Thr Glu Asn Met Glu Asp Val Ile Asn Cys Gln His Ser Met Ser 
            260                 265                 270         


Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly Asp Gly Asp Tyr 
        275                 280                 285             


Pro Glu Phe Met Lys Thr Ser Ser Val Ile Pro Glu Phe Ser Glu Ala 
    290                 295                 300                 


Glu Lys Glu Glu Val Arg Gly Thr Ala Asp Phe Phe Ala Phe Ser Phe 
305                 310                 315                 320 


Gly Pro Asn Asn Phe Arg Pro Ser Asn Thr Val Val Lys Met Gly Gln 
                325                 330                 335     


Asn Val Ser Leu Asn Leu Arg Gln Val Leu Asn Trp Ile Lys Leu Glu 
            340                 345                 350         


Tyr Asp Asn Pro Arg Ile Leu Ile Ser Glu Asn Gly Trp Phe Thr Asp 
        355                 360                 365             


Ser Tyr Ile Lys Thr Glu Asp Thr Thr Ala Ile Tyr Met Met Lys Asn 
    370                 375                 380                 


Phe Leu Asn Gln Val Leu Gln Ala Ile Lys Phe Asp Glu Ile Gln Val 
385                 390                 395                 400 


Phe Gly Tyr Thr Ala Trp Thr Leu Leu Asp Gly Phe Glu Trp Gln Asp 
                405                 410                 415     


Ala Tyr Thr Thr Arg Arg Gly Leu Phe Tyr Val Asp Phe Asn Ser Glu 
            420                 425                 430         


Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala His Tyr Tyr Lys Gln Ile 
        435                 440                 445             


Ile Gln Asp Asn Gly Phe Pro Leu Gln Glu Ser Thr Pro Asp Met Lys 
    450                 455                 460                 


Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly Val Thr Glu Ser Val Leu 
465                 470                 475                 480 


Lys Pro Glu Phe Thr Val Ser Ser Pro Gln Phe Thr Asp Pro His Leu 
                485                 490                 495     


Tyr Val Trp Asn Val Thr Gly Asn Arg Leu Leu Tyr Arg Val Glu Gly 
            500                 505                 510         


Val Arg Leu Lys Thr Arg Pro Ser Gln Cys Thr Asp Tyr Val Ser Ile 
        515                 520                 525             


Lys Lys Arg Val Glu Met Leu Ala Lys Met Lys Val Thr His Tyr Gln 
    530                 535                 540                 


Phe Ala Leu Asp Trp Thr Ser Ile Leu Pro Thr Gly Asn Leu Ser Lys 
545                 550                 555                 560 


Ile Asn Arg Gln Val Leu Arg Tyr Tyr Arg Cys Val Val Ser Glu Gly 
                565                 570                 575     


Leu Lys Leu Gly Ile Ser Pro Met Val Thr Leu Tyr His Pro Thr His 
            580                 585                 590         


Ser His Leu Gly Leu Pro Met Pro Leu Leu Ser Ser Gly Gly Trp Leu 
        595                 600                 605             


Asn Thr Asn Thr Ala Lys Ala Phe Gln Asp Tyr Ala Gly Leu Cys Phe 
    610                 615                 620                 


Lys Glu Leu Gly Asp Leu Val Lys Leu Trp Ile Thr Ile Asn Glu Pro 
625                 630                 635                 640 


Asn Arg Leu Ser Asp Met Tyr Asn Arg Thr Ser Asn Asp Thr Tyr Arg 
                645                 650                 655     


Ala Ala His Asn Leu Met Ile Ala His Ala Gln Val Trp His Leu Tyr 
            660                 665                 670         


Asp Arg Gln Tyr Arg Pro Val Gln His Gly Ala Val Ser Leu Ser Leu 
        675                 680                 685             


His Ser Asp Trp Ala Glu Pro Ala Asn Pro Tyr Val Glu Ser His Trp 
    690                 695                 700                 


Lys Ala Ala Glu Arg Phe Leu Gln Phe Glu Ile Ala Trp Phe Ala Asp 
705                 710                 715                 720 


Pro Leu Phe Lys Thr Gly Asp Tyr Pro Leu Ala Met Lys Glu Tyr Ile 
                725                 730                 735     


Ala Ser Lys Lys Gln Arg Gly Leu Ser Ser Ser Val Leu Pro Arg Phe 
            740                 745                 750         


Thr Leu Lys Glu Ser Arg Leu Val Lys Gly Thr Ile Asp Phe Tyr Ala 
        755                 760                 765             


Leu Asn His Phe Thr Thr Arg Phe Val Ile His Lys Gln Leu Asn Thr 
    770                 775                 780                 


Asn Cys Ser Val Ala Asp Arg Asp Val Gln Phe Leu Gln Asp Ile Thr 
785                 790                 795                 800 


Arg Leu Ser Ser Pro Thr Arg Leu Ala Val Ile Pro Trp Gly Val Arg 
                805                 810                 815     


Lys Leu Leu Arg Trp Val Arg Arg Asn Tyr Gly Asp Met Asp Ile Tyr 
            820                 825                 830         


Ile Thr Ala Ser Gly Ile Asp Asp Gln Ala Leu Glu Asp Asp Arg Leu 
        835                 840                 845             


Arg Lys Tyr Tyr Leu Gly Lys Tyr Leu Gln Glu Val Leu Lys Ala Tyr 
    850                 855                 860                 


Leu Ile Asp Lys Val Arg Ile Lys Gly Tyr Tyr Ala Phe Lys Leu Ala 
865                 870                 875                 880 


Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe Phe Thr Ser Asp Phe Lys 
                885                 890                 895     


Ala Lys Ser Ser Ile Gln Phe Tyr Asn Lys Val Ile Ser Ser Arg Gly 
            900                 905                 910         


Phe Pro Phe Glu Asn Ser Ser Ser Arg Cys Ser Gln Thr Gln Glu Asn 
        915                 920                 925             


Thr Glu Cys Thr Val Cys Leu Phe Leu Val Gln Lys Lys Pro Leu Ile 
    930                 935                 940                 


Phe Leu Gly Cys Cys Phe Phe Ser Thr Leu Val Leu Leu Leu Ser Ile 
945                 950                 955                 960 


Ala Ile Phe Gln Arg Gln Lys Arg Arg Lys Phe Trp Lys Ala Lys Asn 
                965                 970                 975     


Leu Gln His Ile Pro Leu Lys Lys Gly Lys Arg Val Val Ser 
            980                 985                 990 


<210> 53
<211> 990
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 53
Phe Ser Gly Asp Gly Lys Ala Ile Trp Asp Lys Lys Gln Tyr Val Ser 
1               5                   10                  15      


Pro Val Asn Pro Gly Gln Leu Phe Leu Tyr Asp Thr Phe Pro Lys Asn 
            20                  25                  30          


Phe Ser Trp Gly Val Gly Thr Gly Ala Phe Gln Val Glu Gly Ser Trp 
        35                  40                  45              


Lys Ala Asp Gly Arg Gly Pro Ser Ile Trp Asp Arg Tyr Val Asp Ser 
    50                  55                  60                  


His Leu Arg Gly Val Asn Ser Thr Asp Arg Ser Thr Asp Ser Tyr Val 
65                  70                  75                  80  


Phe Leu Glu Lys Asp Leu Leu Ala Leu Asp Phe Leu Gly Val Ser Phe 
                85                  90                  95      


Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro Asn Gly Thr Val 
            100                 105                 110         


Ala Ala Val Asn Ala Lys Gly Leu Gln Tyr Tyr Arg Ala Leu Leu Asp 
        115                 120                 125             


Ser Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr Leu Tyr His Trp 
    130                 135                 140                 


Asp Leu Pro Leu Thr Leu Gln Glu Glu Tyr Gly Gly Trp Lys Asn Ala 
145                 150                 155                 160 


Thr Met Ile Asp Leu Phe Asn Asp Tyr Ala Thr Tyr Cys Phe Gln Thr 
                165                 170                 175     


Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His Asn Pro Tyr Leu 
            180                 185                 190         


Val Ala Trp His Gly Phe Gly Thr Gly Met His Ala Pro Gly Glu Lys 
        195                 200                 205             


Gly Asn Leu Thr Ala Val Tyr Thr Val Gly His Asn Leu Ile Lys Ala 
    210                 215                 220                 


His Ser Lys Val Trp His Asn Tyr Asp Lys Asn Phe Arg Pro His Gln 
225                 230                 235                 240 


Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp Ile Glu Pro Asn 
                245                 250                 255     


Arg Thr Glu Asn Met Glu Asp Val Ile Asn Cys Gln His Ser Met Ser 
            260                 265                 270         


Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly Asp Gly Asp Tyr 
        275                 280                 285             


Pro Glu Phe Met Lys Thr Ser Ser Val Ile Pro Glu Phe Ser Glu Ala 
    290                 295                 300                 


Glu Lys Glu Glu Val Arg Gly Thr Ala Asp Phe Phe Ala Phe Ser Phe 
305                 310                 315                 320 


Gly Pro Asn Asn Phe Arg Pro Ser Asn Thr Val Val Lys Met Gly Gln 
                325                 330                 335     


Asn Val Ser Leu Asn Leu Arg Gln Val Leu Asn Trp Ile Lys Leu Glu 
            340                 345                 350         


Tyr Asp Asn Pro Arg Ile Leu Ile Ser Glu Asn Gly Trp Phe Thr Asp 
        355                 360                 365             


Ser Tyr Ile Lys Thr Glu Asp Thr Thr Ala Ile Tyr Met Met Lys Asn 
    370                 375                 380                 


Phe Leu Asn Gln Val Leu Gln Ala Ile Lys Phe Asp Glu Ile Gln Val 
385                 390                 395                 400 


Phe Gly Tyr Thr Ala Trp Thr Leu Leu Asp Gly Phe Glu Trp Gln Asp 
                405                 410                 415     


Ala Tyr Thr Thr Arg Arg Gly Leu Phe Tyr Val Asp Phe Asn Ser Glu 
            420                 425                 430         


Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala His Tyr Tyr Lys Gln Ile 
        435                 440                 445             


Ile Gln Asp Asn Gly Phe Pro Leu Gln Glu Ser Thr Pro Asp Met Lys 
    450                 455                 460                 


Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly Val Thr Glu Ser Val Leu 
465                 470                 475                 480 


Lys Pro Glu Phe Thr Val Ser Ser Pro Gln Phe Thr Asp Pro His Leu 
                485                 490                 495     


Tyr Val Trp Asn Val Thr Gly Asn Arg Leu Leu Tyr Arg Val Glu Gly 
            500                 505                 510         


Val Arg Leu Lys Thr Arg Pro Ser Gln Cys Thr Asp Tyr Val Ser Ile 
        515                 520                 525             


Lys Lys Arg Val Glu Met Leu Ala Lys Met Lys Val Thr His Tyr Gln 
    530                 535                 540                 


Phe Ala Leu Asp Trp Thr Ser Ile Leu Pro Thr Gly Asn Leu Ser Lys 
545                 550                 555                 560 


Ile Asn Arg Gln Val Leu Arg Tyr Tyr Arg Cys Val Val Ser Glu Gly 
                565                 570                 575     


Leu Lys Leu Gly Ile Ser Pro Met Val Thr Leu Tyr His Pro Thr His 
            580                 585                 590         


Ser His Leu Gly Leu Pro Met Pro Leu Leu Ser Ser Gly Gly Trp Leu 
        595                 600                 605             


Asn Thr Asn Thr Ala Lys Ala Phe Gln Asp Tyr Ala Gly Leu Cys Phe 
    610                 615                 620                 


Lys Glu Leu Gly Asp Leu Val Lys Leu Trp Ile Thr Ile Asn Glu Pro 
625                 630                 635                 640 


Asn Arg Leu Ser Asp Met Tyr Asn Arg Thr Ser Asn Asp Thr Tyr Arg 
                645                 650                 655     


Ala Ala His Asn Leu Met Ile Ala His Ala Gln Val Trp His Leu Tyr 
            660                 665                 670         


Asp Arg Gln Tyr Arg Pro Val Gln His Gly Ala Val Ser Leu Ser Leu 
        675                 680                 685             


His Ser Asp Trp Ala Glu Pro Ala Asn Pro Tyr Val Glu Ser His Trp 
    690                 695                 700                 


Lys Ala Ala Glu Arg Phe Leu Gln Phe Glu Ile Ala Trp Phe Ala Asp 
705                 710                 715                 720 


Pro Leu Phe Lys Thr Gly Asp Tyr Pro Leu Ala Met Lys Glu Tyr Ile 
                725                 730                 735     


Ala Ser Lys Lys Gln Arg Gly Leu Ser Ser Ser Val Leu Pro Arg Phe 
            740                 745                 750         


Thr Leu Lys Glu Ser Arg Leu Val Lys Gly Thr Ile Asp Phe Tyr Ala 
        755                 760                 765             


Leu Asn His Phe Thr Thr Arg Phe Val Ile His Lys Gln Leu Asn Thr 
    770                 775                 780                 


Asn Cys Ser Val Ala Asp Arg Asp Val Gln Phe Leu Gln Asp Ile Thr 
785                 790                 795                 800 


Arg Leu Ser Ser Pro Ser Arg Leu Ala Val Thr Pro Trp Gly Met Arg 
                805                 810                 815     


Lys Leu Leu Gly Trp Ile Arg Arg Asn Tyr Arg Asp Met Asp Ile Tyr 
            820                 825                 830         


Val Thr Ala Asn Gly Ile Asp Asp Gln Ala Leu Glu Asp Asp Arg Leu 
        835                 840                 845             


Arg Lys Tyr Tyr Leu Gly Lys Tyr Leu Gln Glu Val Leu Lys Ala Tyr 
    850                 855                 860                 


Leu Ile Asp Lys Val Arg Ile Lys Gly Tyr Tyr Ala Phe Lys Leu Ala 
865                 870                 875                 880 


Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe Phe Thr Ser Asp Phe Lys 
                885                 890                 895     


Ala Lys Ser Ser Ile Gln Phe Tyr Asn Lys Val Ile Ser Ser Arg Gly 
            900                 905                 910         


Phe Pro Phe Glu Asn Ser Ser Ser Arg Cys Ser Gln Thr Gln Glu Asn 
        915                 920                 925             


Thr Glu Cys Thr Val Cys Leu Phe Leu Val Gln Lys Lys Pro Leu Ile 
    930                 935                 940                 


Phe Leu Gly Cys Cys Phe Phe Ser Thr Leu Val Leu Leu Leu Ser Ile 
945                 950                 955                 960 


Ala Ile Phe Gln Arg Gln Lys Arg Arg Lys Phe Trp Lys Ala Lys Asn 
                965                 970                 975     


Leu Gln His Ile Pro Leu Lys Lys Gly Lys Arg Val Val Ser 
            980                 985                 990 


<210> 54
<211> 990
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 54
Phe Ser Gly Asp Gly Lys Ala Ile Trp Asp Lys Lys Gln Tyr Val Ser 
1               5                   10                  15      


Pro Val Asn Pro Gly Gln Leu Phe Leu Tyr Asp Thr Phe Pro Lys Asn 
            20                  25                  30          


Phe Ser Trp Gly Val Gly Thr Gly Ala Phe Gln Val Glu Gly Ser Trp 
        35                  40                  45              


Lys Ala Asp Gly Arg Gly Pro Ser Ile Trp Asp Arg Tyr Val Asp Ser 
    50                  55                  60                  


His Leu Arg Gly Val Asn Ser Thr Asp Arg Ser Thr Asp Ser Tyr Val 
65                  70                  75                  80  


Phe Leu Glu Lys Asp Leu Leu Ala Leu Asp Phe Leu Gly Val Ser Phe 
                85                  90                  95      


Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro Asn Gly Thr Val 
            100                 105                 110         


Ala Ala Val Asn Ala Lys Gly Leu Gln Tyr Tyr Arg Ala Leu Leu Asp 
        115                 120                 125             


Ser Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr Leu Tyr His Trp 
    130                 135                 140                 


Asp Leu Pro Leu Thr Leu Gln Glu Glu Tyr Gly Gly Trp Lys Asn Ala 
145                 150                 155                 160 


Thr Met Ile Asp Leu Phe Asn Asp Tyr Ala Thr Tyr Cys Phe Gln Thr 
                165                 170                 175     


Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His Asn Pro Tyr Leu 
            180                 185                 190         


Val Ala Trp His Gly Phe Gly Thr Gly Met His Ala Pro Gly Glu Lys 
        195                 200                 205             


Gly Asn Leu Thr Ala Val Tyr Thr Val Gly His Asn Leu Ile Lys Ala 
    210                 215                 220                 


His Ser Lys Val Trp His Asn Tyr Asp Lys Asn Phe Arg Pro His Gln 
225                 230                 235                 240 


Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp Ile Glu Pro Asn 
                245                 250                 255     


Arg Thr Glu Asn Met Glu Asp Val Ile Asn Cys Gln His Ser Met Ser 
            260                 265                 270         


Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly Asp Gly Asp Tyr 
        275                 280                 285             


Pro Glu Phe Met Lys Thr Ser Ser Val Ile Pro Glu Phe Ser Glu Ala 
    290                 295                 300                 


Glu Lys Glu Glu Val Arg Gly Thr Ala Asp Phe Phe Ala Phe Ser Phe 
305                 310                 315                 320 


Gly Pro Asn Asn Phe Arg Pro Ser Asn Thr Val Val Lys Met Gly Gln 
                325                 330                 335     


Asn Val Ser Leu Asn Leu Arg Gln Val Leu Asn Trp Ile Lys Leu Glu 
            340                 345                 350         


Tyr Asp Asn Pro Arg Ile Leu Ile Ser Glu Asn Gly Trp Phe Thr Asp 
        355                 360                 365             


Ser Tyr Ile Lys Thr Glu Asp Thr Thr Ala Ile Tyr Met Met Lys Asn 
    370                 375                 380                 


Phe Leu Asn Gln Val Leu Gln Ala Ile Lys Phe Asp Glu Ile Gln Val 
385                 390                 395                 400 


Phe Gly Tyr Thr Ala Trp Thr Leu Leu Asp Gly Phe Glu Trp Gln Asp 
                405                 410                 415     


Ala Tyr Thr Thr Arg Arg Gly Leu Phe Tyr Val Asp Phe Asn Ser Glu 
            420                 425                 430         


Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala His Tyr Tyr Lys Gln Ile 
        435                 440                 445             


Ile Gln Asp Asn Gly Phe Pro Leu Gln Glu Ser Thr Pro Asp Met Lys 
    450                 455                 460                 


Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly Val Thr Glu Ser Val Leu 
465                 470                 475                 480 


Lys Pro Glu Phe Thr Val Ser Ser Pro Gln Phe Thr Asp Pro His Leu 
                485                 490                 495     


Tyr Val Trp Asn Val Thr Gly Asn Arg Leu Leu Tyr Arg Val Glu Gly 
            500                 505                 510         


Val Arg Leu Lys Thr Arg Pro Ser Gln Cys Thr Asp Tyr Val Ser Ile 
        515                 520                 525             


Lys Lys Arg Val Glu Met Leu Ala Lys Met Lys Val Thr His Tyr Gln 
    530                 535                 540                 


Phe Ala Leu Asp Trp Thr Ser Ile Leu Pro Thr Gly Asn Leu Ser Lys 
545                 550                 555                 560 


Ile Asn Arg Gln Val Leu Arg Tyr Tyr Arg Cys Val Val Ser Glu Gly 
                565                 570                 575     


Leu Lys Leu Gly Ile Ser Pro Met Val Thr Leu Tyr His Pro Thr His 
            580                 585                 590         


Ser His Leu Gly Leu Pro Met Pro Leu Leu Ser Ser Gly Gly Trp Leu 
        595                 600                 605             


Asn Thr Asn Thr Ala Lys Ala Phe Gln Asp Tyr Ala Gly Leu Cys Phe 
    610                 615                 620                 


Lys Glu Leu Gly Asp Leu Val Lys Leu Trp Ile Thr Ile Asn Glu Pro 
625                 630                 635                 640 


Asn Arg Leu Ser Asp Met Tyr Asn Arg Thr Ser Asn Asp Thr Tyr Arg 
                645                 650                 655     


Ala Ala His Asn Leu Met Ile Ala His Ala Gln Val Trp His Leu Tyr 
            660                 665                 670         


Asp Arg Gln Tyr Arg Pro Val Gln His Gly Ala Val Ser Leu Ser Leu 
        675                 680                 685             


His Ser Asp Trp Ala Glu Pro Ala Asn Pro Tyr Val Glu Ser His Trp 
    690                 695                 700                 


Lys Ala Ala Glu Arg Phe Leu Gln Phe Glu Ile Ala Trp Phe Ala Asp 
705                 710                 715                 720 


Pro Leu Phe Lys Thr Gly Asp Tyr Pro Leu Ala Met Lys Glu Tyr Ile 
                725                 730                 735     


Ala Ser Lys Lys Gln Arg Gly Leu Ser Ser Ser Val Leu Pro Arg Phe 
            740                 745                 750         


Thr Leu Lys Glu Ser Arg Leu Val Lys Gly Thr Ile Asp Phe Tyr Ala 
        755                 760                 765             


Leu Asn His Phe Thr Thr Arg Phe Val Ile His Lys Gln Leu Asn Thr 
    770                 775                 780                 


Asn Cys Ser Val Ala Asp Arg Asp Val Gln Phe Leu Gln Asp Ile Thr 
785                 790                 795                 800 


Arg Leu Ser Ser Pro Ser Arg Leu Ala Val Thr Pro Trp Gly Met Arg 
                805                 810                 815     


Lys Leu Leu Gly Trp Ile Arg Arg Asn Tyr Arg Asp Met Asp Ile Tyr 
            820                 825                 830         


Val Thr Ala Asn Gly Ile Asp Asp Leu Ala Leu Glu Asp Asp Gln Ile 
        835                 840                 845             


Arg Lys Tyr Tyr Leu Glu Lys Tyr Val Gln Glu Ala Leu Lys Ala Tyr 
    850                 855                 860                 


Leu Ile Asp Lys Val Lys Ile Lys Gly Tyr Tyr Ala Phe Lys Leu Thr 
865                 870                 875                 880 


Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe Phe Thr Ser Asp Phe Lys 
                885                 890                 895     


Ala Lys Ser Ser Ile Gln Phe Tyr Asn Lys Val Ile Ser Ser Arg Gly 
            900                 905                 910         


Phe Pro Phe Glu Asn Ser Ser Ser Arg Cys Ser Gln Thr Gln Glu Asn 
        915                 920                 925             


Thr Glu Cys Thr Val Cys Leu Phe Leu Val Gln Lys Lys Pro Leu Ile 
    930                 935                 940                 


Phe Leu Gly Cys Cys Phe Phe Ser Thr Leu Val Leu Leu Leu Ser Ile 
945                 950                 955                 960 


Ala Ile Phe Gln Arg Gln Lys Arg Arg Lys Phe Trp Lys Ala Lys Asn 
                965                 970                 975     


Leu Gln His Ile Pro Leu Lys Lys Gly Lys Arg Val Val Ser 
            980                 985                 990 


<210> 55
<211> 991
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 55
Phe Ser Gly Asp Gly Lys Ala Ile Trp Asp Lys Lys Gln Tyr Val Ser 
1               5                   10                  15      


Pro Val Asn Pro Gly Gln Leu Phe Leu Tyr Asp Thr Phe Pro Lys Asn 
            20                  25                  30          


Phe Ser Trp Gly Val Gly Thr Gly Ala Phe Gln Val Glu Gly Ser Trp 
        35                  40                  45              


Lys Ala Asp Gly Arg Gly Pro Ser Ile Trp Asp Arg Tyr Val Asp Ser 
    50                  55                  60                  


His Leu Arg Gly Val Asn Ser Thr Asp Arg Ser Thr Asp Ser Tyr Val 
65                  70                  75                  80  


Phe Leu Glu Lys Asp Leu Leu Ala Leu Asp Phe Leu Gly Val Ser Phe 
                85                  90                  95      


Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro Asn Gly Thr Val 
            100                 105                 110         


Ala Ala Val Asn Ala Lys Gly Leu Gln Tyr Tyr Arg Ala Leu Leu Asp 
        115                 120                 125             


Ser Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr Leu Tyr His Trp 
    130                 135                 140                 


Asp Leu Pro Leu Thr Leu Gln Glu Glu Tyr Gly Gly Trp Lys Asn Ala 
145                 150                 155                 160 


Thr Met Ile Asp Leu Phe Asn Asp Tyr Ala Thr Tyr Cys Phe Gln Thr 
                165                 170                 175     


Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His Asn Pro Tyr Leu 
            180                 185                 190         


Val Ala Trp His Gly Phe Gly Thr Gly Met His Ala Pro Gly Glu Lys 
        195                 200                 205             


Gly Asn Leu Thr Ala Val Tyr Thr Val Gly His Asn Leu Ile Lys Ala 
    210                 215                 220                 


His Ser Lys Val Trp His Asn Tyr Asp Lys Asn Phe Arg Pro His Gln 
225                 230                 235                 240 


Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp Ile Glu Pro Asn 
                245                 250                 255     


Arg Thr Glu Asn Met Glu Asp Val Ile Asn Cys Gln His Ser Met Ser 
            260                 265                 270         


Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly Asp Gly Asp Tyr 
        275                 280                 285             


Pro Glu Phe Met Lys Thr Ser Ser Val Ile Pro Glu Phe Ser Glu Ala 
    290                 295                 300                 


Glu Lys Glu Glu Val Arg Gly Thr Ala Asp Phe Phe Ala Phe Ser Phe 
305                 310                 315                 320 


Gly Pro Asn Asn Phe Arg Pro Ser Asn Thr Val Val Lys Met Gly Gln 
                325                 330                 335     


Asn Val Ser Leu Asn Leu Arg Gln Val Leu Asn Trp Ile Lys Leu Glu 
            340                 345                 350         


Tyr Asp Asn Pro Arg Ile Leu Ile Ser Glu Asn Gly Trp Phe Thr Asp 
        355                 360                 365             


Ser Tyr Ile Lys Thr Glu Asp Thr Thr Ala Ile Tyr Met Met Lys Asn 
    370                 375                 380                 


Phe Leu Asn Gln Val Leu Gln Ala Ile Lys Phe Asp Glu Ile Gln Val 
385                 390                 395                 400 


Phe Gly Tyr Thr Ala Trp Thr Leu Leu Asp Gly Phe Glu Trp Gln Asp 
                405                 410                 415     


Ala Tyr Thr Thr Arg Arg Gly Leu Phe Tyr Val Asp Phe Asn Ser Glu 
            420                 425                 430         


Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala His Tyr Tyr Lys Gln Ile 
        435                 440                 445             


Ile Gln Asp Asn Gly Phe Pro Leu Gln Glu Ser Thr Pro Asp Met Lys 
    450                 455                 460                 


Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly Val Thr Glu Ser Val Leu 
465                 470                 475                 480 


Lys Pro Glu Phe Thr Val Ser Ser Pro Gln Phe Thr Asp Pro His Leu 
                485                 490                 495     


Tyr Val Trp Asn Val Thr Gly Asn Arg Leu Leu Tyr Arg Val Glu Gly 
            500                 505                 510         


Val Arg Leu Lys Thr Arg Pro Ser Gln Cys Thr Asp Tyr Val Ser Ile 
        515                 520                 525             


Lys Lys Arg Val Glu Met Leu Ala Lys Met Lys Val Thr His Tyr Gln 
    530                 535                 540                 


Phe Ala Leu Asp Trp Thr Ser Ile Leu Pro Thr Gly Asn Leu Ser Lys 
545                 550                 555                 560 


Ile Asn Arg Gln Val Leu Arg Tyr Tyr Arg Cys Val Val Ser Glu Gly 
                565                 570                 575     


Leu Lys Leu Gly Ile Ser Pro Met Val Thr Leu Tyr His Pro Thr His 
            580                 585                 590         


Ser His Leu Gly Leu Pro Met Pro Leu Leu Ser Ser Gly Gly Trp Leu 
        595                 600                 605             


Asn Thr Asn Thr Ala Lys Ala Phe Gln Asp Tyr Ala Gly Leu Cys Phe 
    610                 615                 620                 


Lys Glu Leu Gly Asp Leu Val Lys Leu Trp Ile Thr Ile Asn Glu Pro 
625                 630                 635                 640 


Asn Arg Leu Ser Asp Met Tyr Asn Arg Thr Ser Asn Asp Thr Tyr Arg 
                645                 650                 655     


Ala Ala His Asn Leu Met Ile Ala His Ala Gln Val Trp His Leu Tyr 
            660                 665                 670         


Asp Arg Gln Tyr Arg Pro Val Gln His Gly Ala Val Ser Leu Ser Leu 
        675                 680                 685             


His Ser Asp Trp Ala Glu Pro Ala Asn Pro Tyr Val Glu Ser His Trp 
    690                 695                 700                 


Lys Ala Ala Glu Arg Phe Leu Gln Phe Glu Ile Ala Trp Phe Ala Asp 
705                 710                 715                 720 


Pro Leu Phe Lys Thr Gly Asp Tyr Pro Leu Ala Met Lys Glu Tyr Ile 
                725                 730                 735     


Ala Ser Lys Lys Gln Arg Gly Leu Ser Ser Ser Val Leu Pro Arg Phe 
            740                 745                 750         


Thr Leu Lys Glu Ser Arg Leu Val Lys Gly Thr Ile Asp Phe Tyr Ala 
        755                 760                 765             


Leu Asn His Phe Thr Thr Arg Phe Val Ile His Lys Gln Leu Asn Thr 
    770                 775                 780                 


Asn Cys Ser Val Ala Asp Arg Asp Val Gln Phe Leu Gln Asp Ile Thr 
785                 790                 795                 800 


Arg Leu Ser Ser Pro Thr Arg Leu Ala Val Ile Pro Trp Gly Val Arg 
                805                 810                 815     


Lys Leu Leu Arg Trp Val Arg Arg Asn Tyr Gly Asp Met Asp Ile Tyr 
            820                 825                 830         


Ile Thr Ala Ser Gly Ile Asp Asp Gln Ala Leu Glu Asp Asp Arg Leu 
        835                 840                 845             


Arg Lys Tyr Tyr Leu Gly Lys Tyr Leu Gln Glu Val Leu Lys Ala Tyr 
    850                 855                 860                 


Leu Ile Asp Lys Val Arg Ile Lys Gly Tyr Tyr Ala Phe Lys Leu Ala 
865                 870                 875                 880 


Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe Phe Thr Ser Asp Phe Lys 
                885                 890                 895     


Ala Lys Ser Ser Val Gln Phe Tyr Ser Lys Leu Ile Ser Ser Ser Gly 
            900                 905                 910         


Phe Ser Ser Glu Asn Arg Ser Pro Ala Cys Gly Gln Pro Pro Glu Asp 
        915                 920                 925             


Thr Glu Cys Ala Ile Cys Ser Phe Leu Thr Gln Lys Lys Pro Leu Ile 
    930                 935                 940                 


Phe Phe Gly Cys Cys Phe Ile Ser Thr Leu Ala Ala Leu Leu Ser Ile 
945                 950                 955                 960 


Thr Ile Phe His His Arg Lys Arg Arg Lys Phe Gln Lys Ala Arg Asn 
                965                 970                 975     


Leu Gln Asn Ile Pro Leu Lys Lys Gly His Ser Arg Val Phe Ser 
            980                 985                 990     


<210> 56
<211> 991
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 56
Phe Ser Gly Asp Gly Lys Ala Ile Trp Asp Lys Lys Gln Tyr Val Ser 
1               5                   10                  15      


Pro Val Asn Pro Gly Gln Leu Phe Leu Tyr Asp Thr Phe Pro Lys Asn 
            20                  25                  30          


Phe Ser Trp Gly Val Gly Thr Gly Ala Phe Gln Val Glu Gly Ser Trp 
        35                  40                  45              


Lys Ala Asp Gly Arg Gly Pro Ser Ile Trp Asp Arg Tyr Val Asp Ser 
    50                  55                  60                  


His Leu Arg Gly Val Asn Ser Thr Asp Arg Ser Thr Asp Ser Tyr Val 
65                  70                  75                  80  


Phe Leu Glu Lys Asp Leu Leu Ala Leu Asp Phe Leu Gly Val Ser Phe 
                85                  90                  95      


Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro Asn Gly Thr Val 
            100                 105                 110         


Ala Ala Val Asn Ala Lys Gly Leu Gln Tyr Tyr Arg Ala Leu Leu Asp 
        115                 120                 125             


Ser Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr Leu Tyr His Trp 
    130                 135                 140                 


Asp Leu Pro Leu Thr Leu Gln Glu Glu Tyr Gly Gly Trp Lys Asn Ala 
145                 150                 155                 160 


Thr Met Ile Asp Leu Phe Asn Asp Tyr Ala Thr Tyr Cys Phe Gln Thr 
                165                 170                 175     


Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His Asn Pro Tyr Leu 
            180                 185                 190         


Val Ala Trp His Gly Phe Gly Thr Gly Met His Ala Pro Gly Glu Lys 
        195                 200                 205             


Gly Asn Leu Thr Ala Val Tyr Thr Val Gly His Asn Leu Ile Lys Ala 
    210                 215                 220                 


His Ser Lys Val Trp His Asn Tyr Asp Lys Asn Phe Arg Pro His Gln 
225                 230                 235                 240 


Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp Ile Glu Pro Asn 
                245                 250                 255     


Arg Thr Glu Asn Met Glu Asp Val Ile Asn Cys Gln His Ser Met Ser 
            260                 265                 270         


Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly Asp Gly Asp Tyr 
        275                 280                 285             


Pro Glu Phe Met Lys Thr Ser Ser Val Ile Pro Glu Phe Ser Glu Ala 
    290                 295                 300                 


Glu Lys Glu Glu Val Arg Gly Thr Ala Asp Phe Phe Ala Phe Ser Phe 
305                 310                 315                 320 


Gly Pro Asn Asn Phe Arg Pro Ser Asn Thr Val Val Lys Met Gly Gln 
                325                 330                 335     


Asn Val Ser Leu Asn Leu Arg Gln Val Leu Asn Trp Ile Lys Leu Glu 
            340                 345                 350         


Tyr Asp Asn Pro Arg Ile Leu Ile Ser Glu Asn Gly Trp Phe Thr Asp 
        355                 360                 365             


Ser Tyr Ile Lys Thr Glu Asp Thr Thr Ala Ile Tyr Met Met Lys Asn 
    370                 375                 380                 


Phe Leu Asn Gln Val Leu Gln Ala Ile Lys Phe Asp Glu Ile Gln Val 
385                 390                 395                 400 


Phe Gly Tyr Thr Ala Trp Thr Leu Leu Asp Gly Phe Glu Trp Gln Asp 
                405                 410                 415     


Ala Tyr Thr Thr Arg Arg Gly Leu Phe Tyr Val Asp Phe Asn Ser Glu 
            420                 425                 430         


Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala His Tyr Tyr Lys Gln Ile 
        435                 440                 445             


Ile Gln Asp Asn Gly Phe Pro Leu Gln Glu Ser Thr Pro Asp Met Lys 
    450                 455                 460                 


Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly Val Thr Glu Ser Val Leu 
465                 470                 475                 480 


Lys Pro Glu Phe Thr Val Ser Ser Pro Gln Phe Thr Asp Pro His Leu 
                485                 490                 495     


Tyr Val Trp Asn Val Thr Gly Asn Arg Leu Leu Tyr Arg Val Glu Gly 
            500                 505                 510         


Val Arg Leu Lys Thr Arg Pro Ser Gln Cys Thr Asp Tyr Val Ser Ile 
        515                 520                 525             


Lys Lys Arg Val Glu Met Leu Ala Lys Met Lys Val Thr His Tyr Gln 
    530                 535                 540                 


Phe Ala Leu Asp Trp Thr Ser Ile Leu Pro Thr Gly Asn Leu Ser Lys 
545                 550                 555                 560 


Ile Asn Arg Gln Val Leu Arg Tyr Tyr Arg Cys Val Val Ser Glu Gly 
                565                 570                 575     


Leu Lys Leu Gly Ile Ser Pro Met Val Thr Leu Tyr His Pro Thr His 
            580                 585                 590         


Ser His Leu Gly Leu Pro Met Pro Leu Leu Ser Ser Gly Gly Trp Leu 
        595                 600                 605             


Asn Thr Asn Thr Ala Lys Ala Phe Gln Asp Tyr Ala Gly Leu Cys Phe 
    610                 615                 620                 


Lys Glu Leu Gly Asp Leu Val Lys Leu Trp Ile Thr Ile Asn Glu Pro 
625                 630                 635                 640 


Asn Arg Leu Ser Asp Met Tyr Asn Arg Thr Ser Asn Asp Thr Tyr Arg 
                645                 650                 655     


Ala Ala His Asn Leu Met Ile Ala His Ala Gln Val Trp His Leu Tyr 
            660                 665                 670         


Asp Arg Gln Tyr Arg Pro Val Gln His Gly Ala Val Ser Leu Ser Leu 
        675                 680                 685             


His Ser Asp Trp Ala Glu Pro Ala Asn Pro Tyr Val Glu Ser His Trp 
    690                 695                 700                 


Lys Ala Ala Glu Arg Phe Leu Gln Phe Glu Ile Ala Trp Phe Ala Asp 
705                 710                 715                 720 


Pro Leu Phe Lys Thr Gly Asp Tyr Pro Leu Ala Met Lys Glu Tyr Ile 
                725                 730                 735     


Ala Ser Lys Lys Gln Arg Gly Leu Ser Ser Ser Val Leu Pro Arg Phe 
            740                 745                 750         


Thr Leu Lys Glu Ser Arg Leu Val Lys Gly Thr Ile Asp Phe Tyr Ala 
        755                 760                 765             


Leu Asn His Phe Thr Thr Arg Phe Val Ile His Lys Gln Leu Asn Thr 
    770                 775                 780                 


Asn Cys Ser Val Ala Asp Arg Asp Val Gln Phe Leu Gln Asp Ile Thr 
785                 790                 795                 800 


Arg Leu Ser Ser Pro Thr Arg Leu Ala Val Ile Pro Trp Gly Val Arg 
                805                 810                 815     


Lys Leu Leu Arg Trp Val Arg Arg Asn Tyr Gly Asp Met Asp Ile Tyr 
            820                 825                 830         


Ile Thr Ala Ser Gly Ile Asp Asp Leu Ala Leu Glu Asp Asp Gln Ile 
        835                 840                 845             


Arg Lys Tyr Tyr Leu Glu Lys Tyr Val Gln Glu Ala Leu Lys Ala Tyr 
    850                 855                 860                 


Leu Ile Asp Lys Val Lys Ile Lys Gly Tyr Tyr Ala Phe Lys Leu Thr 
865                 870                 875                 880 


Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe Phe Thr Ser Asp Phe Lys 
                885                 890                 895     


Ala Lys Ser Ser Val Gln Phe Tyr Ser Lys Leu Ile Ser Ser Ser Gly 
            900                 905                 910         


Phe Ser Ser Glu Asn Arg Ser Pro Ala Cys Gly Gln Pro Pro Glu Asp 
        915                 920                 925             


Thr Glu Cys Ala Ile Cys Ser Phe Leu Thr Gln Lys Lys Pro Leu Ile 
    930                 935                 940                 


Phe Phe Gly Cys Cys Phe Ile Ser Thr Leu Ala Ala Leu Leu Ser Ile 
945                 950                 955                 960 


Thr Ile Phe His His Arg Lys Arg Arg Lys Phe Gln Lys Ala Arg Asn 
                965                 970                 975     


Leu Gln Asn Ile Pro Leu Lys Lys Gly His Ser Arg Val Phe Ser 
            980                 985                 990     


<210> 57
<211> 799
<212> PRT
<213> Homo sapiens

<400> 57
Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln Pro Trp Gly Ala Pro 
1               5                   10                  15      


Val Glu Val Glu Ser Phe Leu Val His Pro Gly Asp Leu Leu Gln Leu 
            20                  25                  30          


Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile Asn Trp Leu Arg Asp 
        35                  40                  45              


Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg Ile Thr Gly Glu Glu 
    50                  55                  60                  


Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser Gly Leu Tyr Ala Cys 
65                  70                  75                  80  


Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr Tyr Phe Ser Val Asn 
                85                  90                  95      


Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp Asp Asp Asp Asp Asp 
            100                 105                 110         


Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr Lys Pro Asn Pro Val 
        115                 120                 125             


Ala Pro Tyr Trp Thr Ser Pro Glu Lys Met Glu Lys Lys Leu His Ala 
    130                 135                 140                 


Val Pro Ala Ala Lys Thr Val Lys Phe Lys Cys Pro Ser Ser Gly Thr 
145                 150                 155                 160 


Pro Asn Pro Thr Leu Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Pro 
                165                 170                 175     


Asp His Arg Ile Gly Gly Tyr Lys Val Arg Tyr Ala Thr Trp Ser Ile 
            180                 185                 190         


Ile Met Asp Ser Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Ile 
        195                 200                 205             


Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr Gln Leu Asp Val 
    210                 215                 220                 


Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala 
225                 230                 235                 240 


Asn Lys Thr Val Ala Leu Gly Ser Asn Val Glu Phe Met Cys Lys Val 
                245                 250                 255     


Tyr Ser Asp Pro Gln Pro His Ile Gln Trp Leu Lys His Ile Glu Val 
            260                 265                 270         


Asn Gly Ser Lys Ile Gly Pro Asp Asn Leu Pro Tyr Val Gln Ile Leu 
        275                 280                 285             


Lys Thr Ala Gly Val Asn Thr Thr Asp Lys Glu Met Glu Val Leu His 
    290                 295                 300                 


Leu Arg Asn Val Ser Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala 
305                 310                 315                 320 


Gly Asn Ser Ile Gly Leu Ser His His Ser Ala Trp Leu Thr Val Leu 
                325                 330                 335     


Glu Ala Leu Glu Glu Arg Pro Ala Val Met Thr Ser Pro Leu Tyr Leu 
            340                 345                 350         


Glu Ile Ile Ile Tyr Cys Thr Gly Ala Phe Leu Ile Ser Cys Met Val 
        355                 360                 365             


Gly Ser Val Ile Val Tyr Lys Met Lys Ser Gly Thr Lys Lys Ser Asp 
    370                 375                 380                 


Phe His Ser Gln Met Ala Val His Lys Leu Ala Lys Ser Ile Pro Leu 
385                 390                 395                 400 


Arg Arg Gln Val Thr Val Ser Ala Asp Ser Ser Ala Ser Met Asn Ser 
                405                 410                 415     


Gly Val Leu Leu Val Arg Pro Ser Arg Leu Ser Ser Ser Gly Thr Pro 
            420                 425                 430         


Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro Arg Trp 
        435                 440                 445             


Glu Leu Pro Arg Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly 
    450                 455                 460                 


Cys Phe Gly Gln Val Val Leu Ala Glu Ala Ile Gly Leu Asp Lys Asp 
465                 470                 475                 480 


Lys Pro Asn Arg Val Thr Lys Val Ala Val Lys Met Leu Lys Ser Asp 
                485                 490                 495     


Ala Thr Glu Lys Asp Leu Ser Asp Leu Ile Ser Glu Met Glu Met Met 
            500                 505                 510         


Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys 
        515                 520                 525             


Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly 
    530                 535                 540                 


Asn Leu Arg Glu Tyr Leu Gln Ala Arg Arg Pro Pro Gly Leu Glu Tyr 
545                 550                 555                 560 


Cys Tyr Asn Pro Ser His Asn Pro Glu Glu Gln Leu Ser Ser Lys Asp 
                565                 570                 575     


Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala 
            580                 585                 590         


Ser Lys Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val 
        595                 600                 605             


Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp 
    610                 615                 620                 


Ile His His Ile Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro 
625                 630                 635                 640 


Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Ile Tyr Thr His 
                645                 650                 655     


Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr 
            660                 665                 670         


Leu Gly Gly Ser Pro Tyr Pro Gly Val Pro Val Glu Glu Leu Phe Lys 
        675                 680                 685             


Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ser Asn Cys Thr Asn 
    690                 695                 700                 


Glu Leu Tyr Met Met Met Arg Asp Cys Trp His Ala Val Pro Ser Gln 
705                 710                 715                 720 


Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Ile Val Ala 
                725                 730                 735     


Leu Thr Ser Asn Gln Glu Tyr Leu Asp Leu Ser Met Pro Leu Asp Gln 
            740                 745                 750         


Tyr Ser Pro Ser Phe Pro Asp Thr Arg Ser Ser Thr Cys Ser Ser Gly 
        755                 760                 765             


Glu Asp Ser Val Phe Ser His Glu Pro Leu Pro Glu Glu Pro Cys Leu 
    770                 775                 780                 


Pro Arg His Pro Ala Gln Leu Ala Asn Gly Gly Leu Lys Arg Arg 
785                 790                 795                 


<210> 58
<211> 800
<212> PRT
<213> Homo sapiens

<400> 58
Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr Leu Glu Pro Glu Glu 
1               5                   10                  15      


Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu Val Tyr Val Ala Ala 
            20                  25                  30          


Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu Lys Asp Ala Ala Val 
        35                  40                  45              


Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly Pro Asn Asn Arg Thr 
    50                  55                  60                  


Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly Ala Thr Pro Arg Asp 
65                  70                  75                  80  


Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr Val Asp Ser Glu Thr 
                85                  90                  95      


Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val Ser Glu Asn Ser Asn 
        115                 120                 125             


Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu Lys Met Glu Lys Arg 
    130                 135                 140                 


Leu His Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg Cys Pro Ala 
145                 150                 155                 160 


Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu Lys Asn Gly Lys Glu 
                165                 170                 175     


Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg Asn Gln His 
            180                 185                 190         


Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser Asp Lys Gly Asn Tyr 
        195                 200                 205             


Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr His 
    210                 215                 220                 


Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly 
225                 230                 235                 240 


Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly Asp Val Glu Phe Val 
                245                 250                 255     


Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Ile Lys His 
            260                 265                 270         


Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro Tyr Leu 
        275                 280                 285             


Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr Asp Lys Glu Ile Glu 
    290                 295                 300                 


Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr 
305                 310                 315                 320 


Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe His Ser Ala Trp Leu 
                325                 330                 335     


Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu Ile Thr Ala Ser Pro 
            340                 345                 350         


Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly Val Phe Leu Ile Ala 
        355                 360                 365             


Cys Met Val Val Thr Val Ile Leu Cys Arg Met Lys Asn Thr Thr Lys 
    370                 375                 380                 


Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His Lys Leu Thr Lys Arg 
385                 390                 395                 400 


Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Glu Ser Ser Ser Ser 
                405                 410                 415     


Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr Thr Arg Leu Ser Ser 
            420                 425                 430         


Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro 
        435                 440                 445             


Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys Leu Thr Leu Gly Lys 
    450                 455                 460                 


Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Val 
465                 470                 475                 480 


Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val Thr Val Ala Val Lys 
                485                 490                 495     


Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Val Ser 
            500                 505                 510         


Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn 
        515                 520                 525             


Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu 
    530                 535                 540                 


Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Arg Ala Arg Arg Pro 
545                 550                 555                 560 


Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg Val Pro Glu Glu Gln 
                565                 570                 575     


Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr Gln Leu Ala Arg Gly 
            580                 585                 590         


Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala 
        595                 600                 605             


Arg Asn Val Leu Val Thr Glu Asn Asn Val Met Lys Ile Ala Asp Phe 
    610                 615                 620                 


Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr Tyr Lys Lys Thr Thr 
625                 630                 635                 640 


Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp 
                645                 650                 655     


Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Met 
            660                 665                 670         


Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val 
        675                 680                 685             


Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro 
    690                 695                 700                 


Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His 
705                 710                 715                 720 


Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu 
                725                 730                 735     


Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu Tyr Leu Asp Leu Ser 
            740                 745                 750         


Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro Asp Thr Arg Ser Ser 
        755                 760                 765             


Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro Asp Pro Met Pro Tyr 
    770                 775                 780                 


Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn Gly Ser Val Lys Thr 
785                 790                 795                 800 


<210> 59
<211> 797
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 59
Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln Pro Trp Gly Ala Pro 
1               5                   10                  15      


Val Glu Val Glu Ser Phe Leu Val His Pro Gly Asp Leu Leu Gln Leu 
            20                  25                  30          


Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile Asn Trp Leu Arg Asp 
        35                  40                  45              


Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg Ile Thr Gly Glu Glu 
    50                  55                  60                  


Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser Gly Leu Tyr Ala Cys 
65                  70                  75                  80  


Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr Tyr Phe Ser Val Asn 
                85                  90                  95      


Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp Asp Asp Asp Asp Asp 
            100                 105                 110         


Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr Lys Pro Asn Pro Val 
        115                 120                 125             


Ala Pro Tyr Trp Thr Ser Pro Glu Lys Met Glu Lys Lys Leu His Ala 
    130                 135                 140                 


Val Pro Ala Ala Lys Thr Val Lys Phe Lys Cys Pro Ser Ser Gly Thr 
145                 150                 155                 160 


Pro Asn Pro Thr Leu Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Pro 
                165                 170                 175     


Asp His Arg Ile Gly Gly Tyr Lys Val Arg Tyr Ala Thr Trp Ser Ile 
            180                 185                 190         


Ile Met Asp Ser Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Ile 
        195                 200                 205             


Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr Gln Leu Asp Val 
    210                 215                 220                 


Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala 
225                 230                 235                 240 


Asn Lys Thr Val Ala Leu Gly Ser Asn Val Glu Phe Met Cys Lys Val 
                245                 250                 255     


Tyr Ser Asp Pro Gln Pro His Ile Gln Trp Leu Lys His Ile Glu Val 
            260                 265                 270         


Asn Gly Ser Lys Ile Gly Pro Asp Asn Leu Pro Tyr Val Gln Ile Leu 
        275                 280                 285             


Lys Thr Ala Gly Val Asn Thr Thr Asp Lys Glu Met Glu Val Leu His 
    290                 295                 300                 


Leu Arg Asn Val Ser Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala 
305                 310                 315                 320 


Gly Asn Ser Ile Gly Leu Ser His His Ser Ala Trp Leu Thr Val Leu 
                325                 330                 335     


Glu Ala Leu Glu Glu Arg Pro Ala Val Met Thr Ser Pro Asp Tyr Leu 
            340                 345                 350         


Glu Ile Ala Ile Tyr Cys Ile Gly Val Phe Leu Ile Ala Cys Met Val 
        355                 360                 365             


Val Thr Val Ile Leu Cys Arg Met Lys Asn Thr Thr Lys Lys Pro Asp 
    370                 375                 380                 


Phe Ser Ser Gln Pro Ala Val His Lys Leu Thr Lys Arg Ile Pro Leu 
385                 390                 395                 400 


Arg Arg Gln Val Thr Val Ser Ala Glu Ser Ser Ser Ser Met Asn Ser 
                405                 410                 415     


Asn Thr Pro Leu Val Arg Ile Thr Thr Arg Leu Ser Ser Thr Ala Asp 
            420                 425                 430         


Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro 
        435                 440                 445             


Lys Trp Glu Phe Pro Arg Asp Lys Leu Thr Leu Gly Lys Pro Leu Gly 
    450                 455                 460                 


Glu Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Val Gly Ile Asp 
465                 470                 475                 480 


Lys Asp Lys Pro Lys Glu Ala Val Thr Val Ala Val Lys Met Leu Lys 
                485                 490                 495     


Asp Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu 
            500                 505                 510         


Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly 
        515                 520                 525             


Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser 
    530                 535                 540                 


Lys Gly Asn Leu Arg Glu Tyr Leu Arg Ala Arg Arg Pro Pro Gly Met 
545                 550                 555                 560 


Glu Tyr Ser Tyr Asp Ile Asn Arg Val Pro Glu Glu Gln Met Thr Phe 
                565                 570                 575     


Lys Asp Leu Val Ser Cys Thr Tyr Gln Leu Ala Arg Gly Met Glu Tyr 
            580                 585                 590         


Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val 
        595                 600                 605             


Leu Val Thr Glu Asn Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala 
    610                 615                 620                 


Arg Asp Ile Asn Asn Ile Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg 
625                 630                 635                 640 


Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr 
                645                 650                 655     


Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Met Trp Glu Ile 
            660                 665                 670         


Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu 
        675                 680                 685             


Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys 
    690                 695                 700                 


Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His Ala Val Pro 
705                 710                 715                 720 


Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Ile 
                725                 730                 735     


Leu Thr Leu Thr Thr Asn Glu Glu Tyr Leu Asp Leu Ser Gln Pro Leu 
            740                 745                 750         


Glu Gln Tyr Ser Pro Ser Tyr Pro Asp Thr Arg Ser Ser Cys Ser Ser 
        755                 760                 765             


Gly Asp Asp Ser Val Phe Ser Pro Asp Pro Met Pro Tyr Glu Pro Cys 
    770                 775                 780                 


Leu Pro Gln Tyr Pro His Ile Asn Gly Ser Val Lys Thr 
785                 790                 795         


<210> 60
<211> 802
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 60
Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr Leu Glu Pro Glu Glu 
1               5                   10                  15      


Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu Val Tyr Val Ala Ala 
            20                  25                  30          


Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu Lys Asp Ala Ala Val 
        35                  40                  45              


Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly Pro Asn Asn Arg Thr 
    50                  55                  60                  


Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly Ala Thr Pro Arg Asp 
65                  70                  75                  80  


Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr Val Asp Ser Glu Thr 
                85                  90                  95      


Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val Ser Glu Asn Ser Asn 
        115                 120                 125             


Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu Lys Met Glu Lys Arg 
    130                 135                 140                 


Leu His Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg Cys Pro Ala 
145                 150                 155                 160 


Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu Lys Asn Gly Lys Glu 
                165                 170                 175     


Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg Asn Gln His 
            180                 185                 190         


Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser Asp Lys Gly Asn Tyr 
        195                 200                 205             


Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr His 
    210                 215                 220                 


Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly 
225                 230                 235                 240 


Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly Asp Val Glu Phe Val 
                245                 250                 255     


Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Ile Lys His 
            260                 265                 270         


Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro Tyr Leu 
        275                 280                 285             


Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr Asp Lys Glu Ile Glu 
    290                 295                 300                 


Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr 
305                 310                 315                 320 


Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe His Ser Ala Trp Leu 
                325                 330                 335     


Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu Ile Thr Ala Ser Pro 
            340                 345                 350         


Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala Phe Leu Ile Ser 
        355                 360                 365             


Cys Met Val Gly Ser Val Ile Val Tyr Lys Met Lys Ser Gly Thr Lys 
    370                 375                 380                 


Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys Leu Ala Lys Ser 
385                 390                 395                 400 


Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp Ser Ser Ala Ser 
                405                 410                 415     


Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg Leu Ser Ser Ser 
            420                 425                 430         


Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro Glu Asp 
        435                 440                 445             


Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu Gly Lys Pro Leu 
    450                 455                 460                 


Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu Ala Ile Gly Leu 
465                 470                 475                 480 


Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala Val Lys Met Leu 
                485                 490                 495     


Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Ile Ser Glu Met 
            500                 505                 510         


Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu 
        515                 520                 525             


Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu Tyr Ala 
    530                 535                 540                 


Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg Arg Pro Pro Gly 
545                 550                 555                 560 


Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu Glu Gln Leu Ser 
                565                 570                 575     


Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu 
            580                 585                 590         


Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn 
        595                 600                 605             


Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu 
    610                 615                 620                 


Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys Thr Thr Asn Gly 
625                 630                 635                 640 


Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Ile 
                645                 650                 655     


Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu 
            660                 665                 670         


Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val Pro Val Glu Glu 
        675                 680                 685             


Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ser Asn 
    690                 695                 700                 


Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His Ala Val 
705                 710                 715                 720 


Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg 
                725                 730                 735     


Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp Leu Ser Met Pro 
            740                 745                 750         


Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg Ser Ser Thr Cys 
        755                 760                 765             


Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro Leu Pro Glu Glu 
    770                 775                 780                 


Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn Gly Gly Leu Lys 
785                 790                 795                 800 


Arg Arg 
        


<210> 61
<211> 797
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 61
Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln Pro Trp Gly Ala Pro 
1               5                   10                  15      


Val Glu Val Glu Ser Phe Leu Val His Pro Gly Asp Leu Leu Gln Leu 
            20                  25                  30          


Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile Asn Trp Leu Arg Asp 
        35                  40                  45              


Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg Ile Thr Gly Glu Glu 
    50                  55                  60                  


Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser Gly Leu Tyr Ala Cys 
65                  70                  75                  80  


Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr Tyr Phe Ser Val Asn 
                85                  90                  95      


Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp Asp Asp Asp Asp Asp 
            100                 105                 110         


Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr Lys Pro Asn Pro Val 
        115                 120                 125             


Ala Pro Tyr Trp Thr Ser Pro Glu Lys Met Glu Lys Lys Leu His Ala 
    130                 135                 140                 


Val Pro Ala Ala Lys Thr Val Lys Phe Lys Cys Pro Ser Ser Gly Thr 
145                 150                 155                 160 


Pro Asn Pro Thr Leu Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Pro 
                165                 170                 175     


Asp His Arg Ile Gly Gly Tyr Lys Val Arg Tyr Ala Thr Trp Ser Ile 
            180                 185                 190         


Ile Met Asp Ser Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Ile 
        195                 200                 205             


Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr Gln Leu Asp Val 
    210                 215                 220                 


Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala 
225                 230                 235                 240 


Asn Ala Ser Thr Val Val Gly Gly Asp Val Glu Phe Val Cys Lys Val 
                245                 250                 255     


Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Ile Lys His Val Glu Lys 
            260                 265                 270         


Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro Tyr Leu Lys Val Leu 
        275                 280                 285             


Lys Ala Ala Gly Val Asn Thr Thr Asp Lys Glu Ile Glu Val Leu Tyr 
    290                 295                 300                 


Ile Arg Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala 
305                 310                 315                 320 


Gly Asn Ser Ile Gly Ile Ser Phe His Ser Ala Trp Leu Thr Val Leu 
                325                 330                 335     


Pro Ala Pro Gly Arg Glu Lys Glu Ile Thr Ala Ser Pro Asp Tyr Leu 
            340                 345                 350         


Glu Ile Ala Ile Tyr Cys Ile Gly Val Phe Leu Ile Ala Cys Met Val 
        355                 360                 365             


Val Thr Val Ile Leu Cys Arg Met Lys Asn Thr Thr Lys Lys Pro Asp 
    370                 375                 380                 


Phe Ser Ser Gln Pro Ala Val His Lys Leu Thr Lys Arg Ile Pro Leu 
385                 390                 395                 400 


Arg Arg Gln Val Thr Val Ser Ala Glu Ser Ser Ser Ser Met Asn Ser 
                405                 410                 415     


Asn Thr Pro Leu Val Arg Ile Thr Thr Arg Leu Ser Ser Thr Ala Asp 
            420                 425                 430         


Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro 
        435                 440                 445             


Lys Trp Glu Phe Pro Arg Asp Lys Leu Thr Leu Gly Lys Pro Leu Gly 
    450                 455                 460                 


Glu Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Val Gly Ile Asp 
465                 470                 475                 480 


Lys Asp Lys Pro Lys Glu Ala Val Thr Val Ala Val Lys Met Leu Lys 
                485                 490                 495     


Asp Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu 
            500                 505                 510         


Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly 
        515                 520                 525             


Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser 
    530                 535                 540                 


Lys Gly Asn Leu Arg Glu Tyr Leu Arg Ala Arg Arg Pro Pro Gly Met 
545                 550                 555                 560 


Glu Tyr Ser Tyr Asp Ile Asn Arg Val Pro Glu Glu Gln Met Thr Phe 
                565                 570                 575     


Lys Asp Leu Val Ser Cys Thr Tyr Gln Leu Ala Arg Gly Met Glu Tyr 
            580                 585                 590         


Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val 
        595                 600                 605             


Leu Val Thr Glu Asn Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala 
    610                 615                 620                 


Arg Asp Ile Asn Asn Ile Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg 
625                 630                 635                 640 


Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr 
                645                 650                 655     


Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Met Trp Glu Ile 
            660                 665                 670         


Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu 
        675                 680                 685             


Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys 
    690                 695                 700                 


Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His Ala Val Pro 
705                 710                 715                 720 


Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Ile 
                725                 730                 735     


Leu Thr Leu Thr Thr Asn Glu Glu Tyr Leu Asp Leu Ser Gln Pro Leu 
            740                 745                 750         


Glu Gln Tyr Ser Pro Ser Tyr Pro Asp Thr Arg Ser Ser Cys Ser Ser 
        755                 760                 765             


Gly Asp Asp Ser Val Phe Ser Pro Asp Pro Met Pro Tyr Glu Pro Cys 
    770                 775                 780                 


Leu Pro Gln Tyr Pro His Ile Asn Gly Ser Val Lys Thr 
785                 790                 795         


<210> 62
<211> 802
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 62
Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr Leu Glu Pro Glu Glu 
1               5                   10                  15      


Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu Val Tyr Val Ala Ala 
            20                  25                  30          


Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu Lys Asp Ala Ala Val 
        35                  40                  45              


Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly Pro Asn Asn Arg Thr 
    50                  55                  60                  


Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly Ala Thr Pro Arg Asp 
65                  70                  75                  80  


Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr Val Asp Ser Glu Thr 
                85                  90                  95      


Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val Ser Glu Asn Ser Asn 
        115                 120                 125             


Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu Lys Met Glu Lys Arg 
    130                 135                 140                 


Leu His Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg Cys Pro Ala 
145                 150                 155                 160 


Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu Lys Asn Gly Lys Glu 
                165                 170                 175     


Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg Asn Gln His 
            180                 185                 190         


Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser Asp Lys Gly Asn Tyr 
        195                 200                 205             


Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr His 
    210                 215                 220                 


Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly 
225                 230                 235                 240 


Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn Val Glu Phe Met 
                245                 250                 255     


Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln Trp Leu Lys His 
            260                 265                 270         


Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn Leu Pro Tyr Val 
        275                 280                 285             


Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp Lys Glu Met Glu 
    290                 295                 300                 


Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala Gly Glu Tyr Thr 
305                 310                 315                 320 


Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His Ser Ala Trp Leu 
                325                 330                 335     


Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val Met Thr Ser Pro 
            340                 345                 350         


Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala Phe Leu Ile Ser 
        355                 360                 365             


Cys Met Val Gly Ser Val Ile Val Tyr Lys Met Lys Ser Gly Thr Lys 
    370                 375                 380                 


Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys Leu Ala Lys Ser 
385                 390                 395                 400 


Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp Ser Ser Ala Ser 
                405                 410                 415     


Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg Leu Ser Ser Ser 
            420                 425                 430         


Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro Glu Asp 
        435                 440                 445             


Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu Gly Lys Pro Leu 
    450                 455                 460                 


Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu Ala Ile Gly Leu 
465                 470                 475                 480 


Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala Val Lys Met Leu 
                485                 490                 495     


Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Ile Ser Glu Met 
            500                 505                 510         


Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu 
        515                 520                 525             


Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu Tyr Ala 
    530                 535                 540                 


Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg Arg Pro Pro Gly 
545                 550                 555                 560 


Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu Glu Gln Leu Ser 
                565                 570                 575     


Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu 
            580                 585                 590         


Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn 
        595                 600                 605             


Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu 
    610                 615                 620                 


Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys Thr Thr Asn Gly 
625                 630                 635                 640 


Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Ile 
                645                 650                 655     


Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu 
            660                 665                 670         


Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val Pro Val Glu Glu 
        675                 680                 685             


Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ser Asn 
    690                 695                 700                 


Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His Ala Val 
705                 710                 715                 720 


Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg 
                725                 730                 735     


Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp Leu Ser Met Pro 
            740                 745                 750         


Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg Ser Ser Thr Cys 
        755                 760                 765             


Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro Leu Pro Glu Glu 
    770                 775                 780                 


Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn Gly Gly Leu Lys 
785                 790                 795                 800 


Arg Arg 
        


<210> 63
<211> 107
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 63
tttcccttta tcgattgaat tccaccatgg gatggtcatg tatcatcctt tttctagtag       60

caactgcaac tggagtacat tcaactgtgg ctgcaccatc tgtcttc                    107


<210> 64
<211> 43
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 64
tttcccttta agcttaacac tctcccctgt tgaagctctt tgt                         43


<210> 65
<211> 107
<212> PRT
<213> Homo sapiens

<400> 65
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210> 66
<211> 321
<212> DNA
<213> Homo sapiens

<400> 66
cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgctt ctgttgtgtg cctgctgaat aacttctatc cccgtgaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg t                                                321


<210> 67
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 67
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
            20                  25                  30          


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
        35                  40                  45              


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
    50                  55                  60                  


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
65                  70                  75                  80  


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
                85                  90                  95      


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
            100                 105                 110         


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
        115                 120                 125 


<210> 68
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 68
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 69
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 69
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala Tyr Ala 
            


<210> 70
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 70
Gly Gly Gly Gly Ser 
1               5   


<210> 71
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 71
Ser Gly Gly Ser Gly Gly Ser 
1               5           


<210> 72
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 72
Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   


<210> 73
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 73
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210> 74
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 74
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210> 75
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 75
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 76
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 76
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210> 77
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 77
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser 
        35  


<210> 78
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 78
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210> 79
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 79
Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Pro Lys Ser Cys Asp Lys 
1               5                   10                  15      


Thr His Thr Cys Pro Pro Cys Pro 
            20                  


<210> 80
<211> 62
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 80
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25                  30          


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
        35                  40                  45              


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
    50                  55                  60          


<210> 81
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 81
Gly Ser Gly Ser Gly Ser 
1               5       


<210> 82
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 82
Ala Ala Ala 
1           


<210> 83
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 83
Ala Thr Gly Ala Tyr Ala 
1               5       


<210> 84
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 84
atgctctccc ctcctcgg                                                     18


<210> 85
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 85
aggcccctgt gcaatagatg                                                   20


<210> 86
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 86
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 87
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 87
aacttcactg tcttggcagc cgg                                               23


<210> 88
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 88
gatctccagg tacaggggcg agg                                               23


