                         SEQUENCE LISTING

<110>  RESEARCH FOUNDATION AT NATIONWIDE CHILDREN'S HOSPITAL
 
<120>  MATERIALS AND METHODS FOR TREATMENT OF TITAN-BASED MYOPATHIES AND
        OTHER TITINOPATHIES

<130>  28335/50216PCT

<150>  US-62/255,887
<151>  2016-11-16

<160>  78    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  1
ggaggaggtg ggggtcttgg t                                                 21


<210>  2
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  2
ttgagt                                                                   6


<210>  3
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  3
caccggagga ggtgggggtc ttggt                                             25


<210>  4
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  4
aaacaccaag acccccacct cctcc                                             25


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  5
ggtggagcag gtggaggagg t                                                 21


<210>  6
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  6
gggggt                                                                   6


<210>  7
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  7
caccggtgga gcaggtggag gaggt                                             25


<210>  8
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  8
aaacacctcc tccacctgct ccacc                                             25


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  9
tggcattttt tacctttaag t                                                 21


<210>  10
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  10
tggaat                                                                   6


<210>  11
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  11
cacctggcat tttttacctt taagt                                             25


<210>  12
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  12
accgtaaaaa atggaaattc acaaa                                             25


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  13
ttttcaggtt caggttcttg a                                                 21


<210>  14
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  14
aagagt                                                                   6


<210>  15
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  15
caccttttca ggttcaggtt cttga                                             25


<210>  16
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  16
aaaagtccaa gtccaagaac tcaaa                                             25


<210>  17
<211>  148
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  n is a, c, g, or u

<400>  17
nnnnnnnnnn nnnnnnnnnn nguuuuagua cucuguaauu uuagguauga gguagacgaa       60

aauuguacuu auaccuaaaa uuacagaauc uacuaaaaca aggcaaaaug ccguguuuau      120

cucgucaacu uguuggcgag auuuuuuu                                         148


<210>  18
<211>  900
<212>  DNA
<213>  Homo sapiens

<400>  18
ctttacatat accaaataca acaacatgta tacatcatac agacaagggt aaacatacat       60

ttcataagaa acaacattta cactcggagt aagaatccaa aggtacattg aacatgacaa      120

agagagtaca gttgacaccg aacagaccta cgaaacaaac aacaacaata accacggaaa      180

cgacataaag agtagtagaa acatttccca actataaaaa tacaaaatac aagacacaaa      240

atacaaccta tgaccataat gcatggaatt tttcatttga aacatgaagt atatatatat      300

atatatatat atatatatat atatatatat attaaagata atttatatga tgtataggtg      360

tacgattgta tatgtatatg attgtggaga ctttatgaga aagttcttgg acttggactt      420

ttccaataac tcttcggttt tgagtttggt tctgggggtg gaggaggtgg acgaggtgga      480

ttccttctac acttcctctt ttataaggtt gaatttccat tttttacggt gaaggtttca      540

aaataatcgg acgaagtttg aagataggtc ggtagacttt actacgaacg ttctttacat      600

actgaaaatc ttcacacatg aaagtctgta ctaacatgac actctaacgt atctcgacag      660

agaagacgac ggggtaccaa ggacccaacg aacagtacgg tacggacgac gacgttttca      720

gtctttcatg taactatcgc agtaggccct atagacttac gtccgtgaca ggttaattga      780

aagaaaacac ctcacccctc tttctcaaaa gactaaagtt tcggactaac gatatgtata      840

gtaacgctag aatacgaatt ccttacatat tctttaggaa cgttctataa aaattataac      900


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  19
agtatatgta tatgttagca t                                                 21


<210>  20
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  20
gtggat                                                                   6


<210>  21
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  21
caccagtata tgtatatgtt agcat                                             25


<210>  22
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  22
tcatatacat atacaatcgt acaaa                                             25


<210>  23
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  23
tgcaagcatc atttcagatg g                                                 21


<210>  24
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  24
ctggat                                                                   6


<210>  25
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  25
cacctgcaag catcatttca gatgg                                             25


<210>  26
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  26
acgttcgtag taaagtctac ccaaa                                             25


<210>  27
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  27
agaagattta agtccactgg a                                                 21


<210>  28
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  28
gataaagaag atttaagtcc a                                                 21


<210>  29
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  29
atgaggctca catttacaac a                                                 21


<210>  30
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  30
tgatagcgtc atccgggata t                                                 21


<210>  31
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  31
gtacaagtta catggaaacc t                                                 21


<210>  32
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  32
ttttatgttc tgtgttttat g                                                 21


<210>  33
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  33
tgtccaatta actttctttt g                                                 21


<210>  34
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  34
ttcttttgtg gagtggggag a                                                 21


<210>  35
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  35
aagtacattg atagcgtcat c                                                 21


<210>  36
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  36
tcttctgctg ccccatggtt c                                                 21


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  37
atcattgcga tcttatgctt a                                                 21


<210>  38
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  38
gtatttctca tcatctttgt a                                                 21


<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  39
cagtgcctgc attcagatat c                                                 21


<210>  40
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  40
ctcatgtcaa ctgtggcttg t                                                 21


<210>  41
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  41
aaccatatac atttcaagag a                                                 21


<210>  42
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  42
ttgaat                                                                   6


<210>  43
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  43
ctggat                                                                   6


<210>  44
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  44
aagaat                                                                   6


<210>  45
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  45
ctgaat                                                                   6


<210>  46
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  46
aagaat                                                                   6


<210>  47
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  47
ttggat                                                                   6


<210>  48
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  48
tggagt                                                                   6


<210>  49
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  49
aagagt                                                                   6


<210>  50
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  50
cgggat                                                                   6


<210>  51
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  51
ctgggt                                                                   6


<210>  52
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  52
aggaat                                                                   6


<210>  53
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  53
aagggt                                                                   6


<210>  54
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  54
ccggat                                                                   6


<210>  55
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  55
ctggat                                                                   6


<210>  56
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  56
aagaat                                                                   6


<210>  57
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  57
ggagctgtaa gagaatgtca t                                                 21


<210>  58
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  58
cagaat                                                                   6


<210>  59
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  59
attccacatg aggagctgta a                                                 21


<210>  60
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  60
gagaat                                                                   6


<210>  61
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  61
attctcttac agctcctcat g                                                 21


<210>  62
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  62
tggaat                                                                   6


<210>  63
<211>  900
<212>  DNA
<213>  Homo sapiens

<400>  63
ccatagtgct tcacgtgttc tatctttgaa ttctgctaat ttctcaaaga ttgtgctaag       60

tgccttaaat aagacaatgt ttctttgcca ctggtgtctg aagtttcctt tgacattatc      120

tttcaagtct ggtgcagtgc aaatgaagat ttttcctcca gctattattc aaaagaactg      180

agatggctcc ctagtatata tactgtacac acacacatgc acactagttg aacatataga      240

atgccacata attttatgta aactaaagag atatctaaaa agcaaagcat catacctgat      300

gggcagcttc aagtgatttc aaagtcagtt gtagtctatt aagatggaaa atccctaaaa      360

aagagtcact ttttcttaat gtatactatg gtaatgtcag agtaaatttc cagaaacctc      420

attttgaatt ctgatgacat tctcttacag ctcctcatgt ggaattctta agaccactca      480

ccgaccttca agttagagaa aaagaaatgg ctcgatttga gtgtgaactt tcccgagaaa      540

atgctaaggt ctgtgactgt atacctgtca tcttgtactg tcaaataact ttatatttac      600

ttttggtcta gccaaaatgg aaaaaaaaaa gttagtcaca acttctctgg tcaccacttt      660

acttttaaag ataattgtag tataaaatgt attcttgact ttaattgctc tctttttagt      720

attattaatt tactattact tgaaaaacac tggactcaca atcaggagat ttagatatta      780

gtttgaacca tatgaaagtg ctgttttctt agatcagaaa gtcaaatatc agcaattata      840

tttctttcaa ctaagtacct cctgttgcta ttaactacca ttggcaagtt tcttcaagtc      900


<210>  64
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  64
ttagataaaa tattggcact c                                                 21


<210>  65
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  65
tggaat                                                                   6


<210>  66
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  66
tatatattca gagtttggct t                                                 21


<210>  67
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  67
ttgggt                                                                   6


<210>  68
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  68
aaattaccca aaagccaaac t                                                 21


<210>  69
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  69
ctgaat                                                                   6


<210>  70
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  70
aaagacacaa aagtatatat t                                                 21


<210>  71
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  71
cagagt                                                                   6


<210>  72
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  72
agcaaaatta acgtggatat g                                                 21


<210>  73
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  73
tagaat                                                                   6


<210>  74
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  74
acatatccac gttaattttg c                                                 21


<210>  75
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  75
tagaat                                                                   6


<210>  76
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  76
cgttaatttt gctagaatag t                                                 21


<210>  77
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  77
gtgagt                                                                   6


<210>  78
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  n is a, c, g, or t

<400>  78
nnnnnnnnnn nnnnnnnnnn ngrrt                                             25


