                         SEQUENCE LISTING

<110>  Trustees of the University of Pennsylvania
 
<120>  COMPOSITIONS AND METHODS FOR CORRECTION OF HERITABLE OCULAR 
       DISEASE

<130>  UPN-15-7313PCT

<150>  us 62/257500
<151>  2015-11-19

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  12513
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV ABCA4 3'RTM CMV synthetic construct

<400>  1
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gcaagctagc      180

tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg      240

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt      300

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      360

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      420

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      480

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattaa      540

catggtcgag gtgagcccca cgttctgctt cactctcccc atctcccccc cctccccacc      600

cccaattttg tatttattta ttttttaatt attttgtgca gcgatggggg cggggggggg      660

gggggggcgc gcgccaggcg gggcggggcg gggcgagggg cggggcgggg cgaggcggag      720

aggtgcggcg gcagccaatc agagcggcgc gctccgaaag tttcctttta tggcgaggcg      780

gcggcggcgg cggccctata aaaagcgaag cgcgcggcgg gcggggagtc gctgcgacgc      840

tgccttcgcc ccgtgccccg ctccgccgcc gcctcgcgcc gcccgccccg gctctgactg      900

accgcgttac tcccacaggt aagtatcaag gttacaagac aggtttaagg agaccaatag      960

aaactgggct tgtcgagaca gagaagactc ttgcgtttct gataggcacc tattggtctt     1020

actgacatcc actttgcctt tctctccaca ggttggtgta cactagcggc cgcaaactct     1080

gctacactca cacatgcttt gtgtggctgt gggtttgata aaagttcatg gaaggagcta     1140

gttggtgccc aggctgacac atgtagaaga gagacttcta gaatccacag gaattttggt     1200

ccccatgttt tcaaagccca tacaagcttc gaattcgata tcgagaacat tattatagcg     1260

ttgctcgagt actaactggt acctcttctt ttttttcgtg gcgctcagca gaaaagagaa     1320

aacgtcaacc cccgacaccc ctgcttgggt cccagagaga aggctggaca gacaccccag     1380

gactccaatg tctgctcccc aggggcgccg gctgctcacc cagagggcca gcctccccca     1440

gagccagagt gcccaggccc gcagctcaac acggggacac agctggtcct ccagcatgtg     1500

caggcgctgc tggtcaagag attccaacac accatccgca gccacaagga cttcctggcg     1560

cagatcgtgc tcccggctac ctttgtgttt ttggctctga tgctttctat tgttatccct     1620

ccttttggcg aataccccgc tttgaccctt cacccctgga tatatgggca gcagtacacc     1680

ttcttcagca tggatgaacc aggcagtgag cagttcacgg tacttgcaga cgtcctcctg     1740

aataagccag gctttggcaa ccgctgcctg aaggaagggt ggcttccgga gtacccctgt     1800

ggcaactcaa caccctggaa gactccttct gtgtccccaa acatcaccca gctgttccag     1860

aagcagaaat ggacacaggt caacccttca ccatcctgca ggtgcagcac cagggagaag     1920

ctcaccatgc tgccagagtg ccccgagggt gccgggggcc tcccgccccc ccagagaaca     1980

cagcgcagca cggaaattct acaagacctg acggacagga acatctccga cttcttggta     2040

aaaacgtatc ctgctcttat aagaagcagc ttaaagagca aattctgggt caatgaacag     2100

aggtatggag gaatttccat tggaggaaag ctcccagtcg tccccatcac gggggaagca     2160

cttgttgggt ttttaagcga ccttggccgg atcatgaatg tgagcggggg ccctatcact     2220

agagaggcct ctaaagaaat acctgatttc cttaaacatc tagaaactga agacaacatt     2280

aaggtgtggt ttaataacaa aggctggcat gccctggtca gctttctcaa tgtggcccac     2340

aacgccatct tacgggccag cctgcctaag gacaggagcc ccgaggagta tggaatcacc     2400

gtcattagcc aacccctgaa cctgaccaag gagcagctct cagagattac agtgctgacc     2460

acttcagtgg atgctgtggt tgccatctgc gtgattttct ccatgtcctt cgtcccagcc     2520

agctttgtcc tttatttgat ccaggagcgg gtgaacaaat ccaagcacct ccagtttatc     2580

agtggagtga gccccaccac ctactgggtg accaacttcc tctgggacat catgaattat     2640

tccgtgagtg ctgggctggt ggtgggcatc ttcatcgggt ttcagaagaa agcctacact     2700

tctccagaaa accttcctgc ccttgtggca ctgctcctgc tgtatggatg ggcggtcatt     2760

cccatgatgt acccagcatc cttcctgttt gatgtcccca gcacagccta tgtggcttta     2820

tcttgtgcta atctgttcat cggcatcaac agcagtgcta ttaccttcat cttggaatta     2880

tttgagaata accggacgct gctcaggttc aacgccgtgc tgaggaagct gctcattgtc     2940

ttcccccact tctgcctggg ccggggcctc attgaccttg cactgagcca ggctgtgaca     3000

gatgtctatg cccggtttgg tgaggagcac tctgcaaatc cgttccactg ggacctgatt     3060

gggaagaacc tgtttgccat ggtggtggaa ggggtggtgt acttcctcct gaccctgctg     3120

gtccagcgcc acttcttcct ctcccaatgg attgccgagc ccactaagga gcccattgtt     3180

gatgaagatg atgatgtggc tgaagaaaga caaagaatta ttactggtgg aaataaaact     3240

gacatcttaa ggctacatga actaaccaag atttatccag gcacctccag cccagcagtg     3300

gacaggctgt gtgtcggagt tcgccctgga gagtgctttg gcctcctggg agtgaatggt     3360

gccggcaaaa caaccacatt caagatgctc actggggaca ccacagtgac ctcaggggat     3420

gccaccgtag caggcaagag tattttaacc aatatttctg aagtccatca aaatatgggc     3480

tactgtcctc agtttgatgc aattgatgag ctgctcacag gacgagaaca tctttacctt     3540

tatgcccggc ttcgaggtgt accagcagaa gaaatcgaaa aggttgcaaa ctggagtatt     3600

aagagcctgg gcctgactgt ctacgccgac tgcctggctg gcacgtacag tgggggcaac     3660

aagcggaaac tctccacagc catcgcactc attggctgcc caccgctggt gctgctggat     3720

gagcccacca cagggatgga cccccaggca cgccgcatgc tgtggaacgt catcgtgagc     3780

atcatcagag aagggagggc tgtggtcctc acatcccaca gcatggaaga atgtgaggca     3840

ctgtgtaccc ggctggccat catggtaaag ggcgcctttc gatgtatggg caccattcag     3900

catctcaagt ccaaatttgg agatggctat atcgtcacaa tgaagatcaa atccccgaag     3960

gacgacctgc ttcctgacct gaaccctgtg gagcagttct tccaggggaa cttcccaggc     4020

agtgtgcaga gggagaggca ctacaacatg ctccagttcc aggtctcctc ctcctccctg     4080

gcgaggatct tccagctcct cctctcccac aaggacagcc tgctcatcga ggagtactca     4140

gtcacacaga ccacactgga ccaggtgttt gtaaattttg ctaaacagca gactgaaagt     4200

catgacctcc ctctgcaccc tcgagctgct ggagccagtc gacaagccca ggactgactg     4260

cagatctgcc tcgactgtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt     4320

gccttccttg accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat     4380

tgcatcgcat tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag     4440

caagggggag gattgggaag acaatagcag gcatgctggg gactcgagtt ctacgtagat     4500

aagtagcatg gcgggttaat cattaactac aaggaacccc tagtgatgga gttggccact     4560

ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg     4620

ggctttgccc gggcggcctc agtgagcgag cgagcgcgca gccttaatta acctaaggaa     4680

aatgaagtga agttcctata ctttctagag aataggaact tctatagtga gtcgaataag     4740

ggcgacacaa aatttattct aaatgcataa taaatactga taacatctta tagtttgtat     4800

tatattttgt attatcgttg acatgtataa ttttgatatc aaaaactgat tttcccttta     4860

ttattttcga gatttatttt cttaattctc tttaacaaac tagaaatatt gtatatacaa     4920

aaaatcataa ataatagatg aatagtttaa ttataggtgt tcatcaatcg aaaaagcaac     4980

gtatcttatt taaagtgcgt tgcttttttc tcatttataa ggttaaataa ttctcatata     5040

tcaagcaaag tgacaggcgc ccttaaatat tctgacaaat gctctttccc taaactcccc     5100

ccataaaaaa acccgccgaa gcgggttttt acgttatttg cggattaacg attactcgtt     5160

atcagaaccg cccagggggc ccgagcttaa cctttttatt tgggggagag ggaagtcatg     5220

aaaaaactaa cctttgaaat tcgatctcca gcacatcagc aaaacgctat tcacgcagta     5280

cagcaaatcc ttccagaccc aaccaaacca atcgtagtaa ccattcagga acgcaaccgc     5340

agcttagacc aaaacaggaa gctatgggcc tgcttaggtg acgtctctcg tcaggttgaa     5400

tggcatggtc gctggctgga tgcagaaagc tggaagtgtg tgtttaccgc agcattaaag     5460

cagcaggatg ttgttcctaa ccttgccggg aatggctttg tggtaatagg ccagtcaacc     5520

agcaggatgc gtgtaggcga atttgcggag ctattagagc ttatacaggc attcggtaca     5580

gagcgtggcg ttaagtggtc agacgaagcg agactggctc tggagtggaa agcgagatgg     5640

ggagacaggg ctgcatgata aatgtcgtta gtttctccgg tggcaggacg tcagcatatt     5700

tgctctggct aatggagcaa aagcgacggg caggtaaaga cgtgcattac gttttcatgg     5760

atacaggttg tgaacatcca atgacatatc ggtttgtcag ggaagttgtg aagttctggg     5820

atataccgct caccgtattg caggttgata tcaacccgga gcttggacag ccaaatggtt     5880

atacggtatg ggaaccaaag gatattcaga cgcgaatgcc tgttctgaag ccatttatcg     5940

atatggtaaa gaaatatggc actccatacg tcggcggcgc gttctgcact gacagattaa     6000

aactcgttcc cttcaccaaa tactgtgatg accatttcgg gcgagggaat tacaccacgt     6060

ggattggcat cagagctgat gaaccgaagc ggctaaagcc aaagcctgga atcagatatc     6120

ttgctgaact gtcagacttt gagaaggaag atatcctcgc atggtggaag caacaaccat     6180

tcgatttgca aataccggaa catctcggta actgcatatt ctgcattaaa aaatcaacgc     6240

aaaaaatcgg acttgcctgc aaagatgagg agggattgca gcgtgttttt aatgaggtca     6300

tcacgggatc ccatgtgcgt gacggacatc gggaaacgcc aaaggagatt atgtaccgag     6360

gaagaatgtc gctggacggt atcgcgaaaa tgtattcaga aaatgattat caagccctgt     6420

atcaggacat ggtacgagct aaaagattcg ataccggctc ttgttctgag tcatgcgaaa     6480

tatttggagg gcagcttgat ttcgacttcg ggagggaagc tgcatgatgc gatgttatcg     6540

gtgcggtgaa tgcaaagaag ataaccgctt ccgaccaaat caaccttact ggaatcgatg     6600

gtgtctccgg tgtgaaagaa caccaacagg ggtgttacca ctaccgcagg aaaaggagga     6660

cgtgtggcga gacagcgacg aagtatcacc gacataatct gcgaaaactg caaatacctt     6720

ccaacgaaac gcaccagaaa taaacccaag ccaatcccaa aagaatctga cgtaaaaacc     6780

ttcaactaca cggctcacct gtgggatatc cggtggctaa gacgtcgtgc gaggaaaaca     6840

aggtgattga ccaaaatcga agttacgaac aagaaagcgt cgagcgagct ttaacgtgcg     6900

ctaactgcgg tcagaagctg catgtgctgg aagttcacgt gtgtgagcac tgctgcgcag     6960

aactgatgag cgatccgaat agctcgatgc acgaggaaga agatgatggc taaaccagcg     7020

cgaagacgat gtaaaaacga tgaatgccgg gaatggtttc accctgcatt cgctaatcag     7080

tggtggtgct ctccagagtg tggaaccaag atagcactcg aacgacgaag taaagaacgc     7140

gaaaaagcgg aaaaagcagc agagaagaaa cgacgacgag aggagcagaa acagaaagat     7200

aaacttaaga ttcgaaaact cgccttaaag ccccgcagtt actggattaa acaagcccaa     7260

caagccgtaa acgccttcat cagagaaaga gaccgcgact taccatgtat ctcgtgcgga     7320

acgctcacgt ctgctcagtg ggatgccgga cattaccgga caactgctgc ggcacctcaa     7380

ctccgattta atgaacgcaa tattcacaag caatgcgtgg tgtgcaacca gcacaaaagc     7440

ggaaatctcg ttccgtatcg cgtcgaactg attagccgca tcgggcagga agcagtagac     7500

gaaatcgaat caaaccataa ccgccatcgc tggactatcg aagagtgcaa ggcgatcaag     7560

gcagagtacc aacagaaact caaagacctg cgaaatagca gaagtgaggc cgcatgacgt     7620

tctcagtaaa aaccattcca gacatgctcg ttgaagcata cggaaatcag acagaagtag     7680

cacgcagact gaaatgtagt cgcggtacgg tcagaaaata cgttgatgat aaagacggga     7740

aaatgcacgc catcgtcaac gacgttctca tggttcatcg cggatggagt gaaagagatg     7800

cgctattacg aaaaaattga tggcagcaaa taccgaaata tttgggtagt tggcgatctg     7860

cacggatgct acacgaacct gatgaacaaa ctggatacga ttggattcga caacaaaaaa     7920

gacctgctta tctcggtggg cgatttggtt gatcgtggtg cagagaacgt tgaatgcctg     7980

gaattaatca cattcccctg gttcagagct gtacgtggaa accatgagca aatgatgatt     8040

gatggcttat cagagcgtgg aaacgttaat cactggctgc ttaatggcgg tggctggttc     8100

tttaatctcg attacgacaa agaaattctg gctaaagctc ttgcccataa agcagatgaa     8160

cttccgttaa tcatcgaact ggtgagcaaa gataaaaaat atgttatctg ccacgccgat     8220

tatccctttg acgaatacga gtttggaaag ccagttgatc atcagcaggt aatctggaac     8280

cgcgaacgaa tcagcaactc acaaaacggg atcgtgaaag aaatcaaagg cgcggacacg     8340

ttcatctttg gtcatacgcc agcagtgaaa ccactcaagt ttgccaacca aatgtatatc     8400

gataccggcg cagtgttctg cggaaaccta acattgattc aggtacaggg agaaggcgca     8460

tgagactcga aagcgtagct aaatttcatt cgccaaaaag cccgatgatg agcgactcac     8520

cacgggccac ggcttctgac tctctttccg gtactgatgt gatggctgct atggggatgg     8580

cgcaatcaca agccggattc ggtatggctg cattctgcgg taagcacgaa ctcagccaga     8640

acgacaaaca aaaggctatc aactatctga tgcaatttgc acacaaggta tcggggaaat     8700

accgtggtgt ggcaaagctt gaaggaaata ctaaggcaaa ggtactgcaa gtgctcgcaa     8760

cattcgctta tgcggattat tgccgtagtg ccgcgacgcc gggggcaaga tgcagagatt     8820

gccatggtac aggccgtgcg gttgatattg ccaaaacaga gctgtggggg agagttgtcg     8880

agaaagagtg cggaagatgc aaaggcgtcg gctattcaag gatgccagca agcgcagcat     8940

atcgcgctgt gacgatgcta atcccaaacc ttacccaacc cacctggtca cgcactgtta     9000

agccgctgta tgacgctctg gtggtgcaat gccacaaaga agagtcaatc gcagacaaca     9060

ttttgaatgc ggtcacacgt tagcagcatg attgccacgg atggcaacat attaacggca     9120

tgatattgac ttattgaata aaattgggta aatttgactc aacgatgggt taattcgctc     9180

gttgtggtag tgagatgaaa agaggcggcg cttactaccg attccgccta gttggtcact     9240

tcgacgtatc gtctggaact ccaaccatcg caggcagaga ggtctgcaaa atgcaatccc     9300

gaaacagttc gcaggtaata gttagagcct gcataacggt ttcgggattt tttatatctg     9360

cacaacaggt aagagcattg agtcgataat cgtgaagagt cggcgagcct ggttagccag     9420

tgctctttcc gttgtgctga attaagcgaa taccggaagc agaaccggat caccaaatgc     9480

gtacaggcgt catcgccgcc cagcaacagc acaacccaaa ctgagccgta gccactgtct     9540

gtcctgaatt cattagtaat agttacgctg cggcctttta cacatgacct tcgtgaaagc     9600

gggtggcagg aggtcgcgct aacaacctcc tgccgttttg cccgtgcata tcggtcacga     9660

acaaatctga ttactaaaca cagtagcctg gatttgttct atcagtaatc gaccttattc     9720

ctaattaaat agagcaaatc cccttattgg gggtaagaca tgaagatgcc agaaaaacat     9780

gacctgttgg ccgccattct cgcggcaaag gaacaaggca tcggggcaat ccttgcgttt     9840

gcaatggcgt accttcgcgg cagatataat ggcggtgcgt ttacaaaaac agtaatcgac     9900

gcaacgatgt gcgccattat cgcctggttc attcgtgacc ttctcgactt cgccggacta     9960

agtagcaatc tcgcttatat aacgagcgtg tttatcggct acatcggtac tgactcgatt    10020

ggttcgctta tcaaacgctt cgctgctaaa aaagccggag tagaagatgg tagaaatcaa    10080

taatcaacgt aaggcgttcc tcgatatgct ggcgtggtcg gagggaactg ataacggacg    10140

tcagaaaacc agaaatcatg gttatgacgt cattgtaggc ggagagctat ttactgatta    10200

ctccgatcac cctcgcaaac ttgtcacgct aaacccaaaa ctcaaatcaa caggcgctta    10260

agactggccg tcgttttaca acacagaaag agtttgtaga aacgcaaaaa ggccatccgt    10320

caggggcctt ctgcttagtt tgatgcctgg cagttcccta ctctcgcctt ccgcttcctc    10380

gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa    10440

ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa    10500

aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct    10560

ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac    10620

aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc    10680

gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc    10740

tcatagctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg    10800

tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga    10860

gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta acaggattag    10920

cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtgggcta actacggcta    10980

cactagaaga acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag    11040

agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg    11100

caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac    11160

ggggtctgac gctcagtgga acgacgcgcg cgtaactcac gttaagggat tttggtcatg    11220

agcttgcgcc gtcccgtcaa gtcagcgtaa tgctctgctt ttagaaaaac tcatcgagca    11280

tcaaatgaaa ctgcaattta ttcatatcag gattatcaat accatatttt tgaaaaagcc    11340

gtttctgtaa tgaaggagaa aactcaccga ggcagttcca taggatggca agatcctggt    11400

atcggtctgc gattccgact cgtccaacat caatacaacc tattaatttc ccctcgtcaa    11460

aaataaggtt atcaagtgag aaatcaccat gagtgacgac tgaatccggt gagaatggca    11520

aaagtttatg catttctttc cagacttgtt caacaggcca gccattacgc tcgtcatcaa    11580

aatcactcgc atcaaccaaa ccgttattca ttcgtgattg cgcctgagcg aggcgaaata    11640

cgcgatcgct gttaaaagga caattacaaa caggaatcga gtgcaaccgg cgcaggaaca    11700

ctgccagcgc atcaacaata ttttcacctg aatcaggata ttcttctaat acctggaacg    11760

ctgtttttcc ggggatcgca gtggtgagta accatgcatc atcaggagta cggataaaat    11820

gcttgatggt cggaagtggc ataaattccg tcagccagtt tagtctgacc atctcatctg    11880

taacatcatt ggcaacgcta cctttgccat gtttcagaaa caactctggc gcatcgggct    11940

tcccatacaa gcgatagatt gtcgcacctg attgcccgac attatcgcga gcccatttat    12000

acccatataa atcagcatcc atgttggaat ttaatcgcgg cctcgacgtt tcccgttgaa    12060

tatggctcat attcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca    12120

tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtc agtgttacaa    12180

ccaattaacc aattctgaac attatcgcga gcccatttat acctgaatat ggctcataac    12240

accccttgtt tgcctggcgg cagtagcgcg gtggtcccac ctgaccccat gccgaactca    12300

gaagtgaaac gccgtagcgc cgatggtagt gtggggactc cccatgcgag agtagggaac    12360

tgccaggcat caaataaaac gaaaggctca gtcgaaagac tgggcctttc gcccgggcta    12420

attagggggt gtcgccctta ttcgactcta tagtgaagtt cctattctct agaaagtata    12480

ggaacttctg aagtggggtc gacttaatta agg                                 12513


<210>  2
<211>  13227
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV CEP290 5'RTM CMV CBA Ex1_26 5'SS BD_5.1

       synthetic DNA construct - recombinant plasmid

<400>  2
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gcaagctagc      180

tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg      240

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt      300

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      360

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      420

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      480

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattaa      540

catggtcgag gtgagcccca cgttctgctt cactctcccc atctcccccc cctccccacc      600

cccaattttg tatttattta ttttttaatt attttgtgca gcgatggggg cggggggggg      660

gggggggcgc gcgccaggcg gggcggggcg gggcgagggg cggggcgggg cgaggcggag      720

aggtgcggcg gcagccaatc agagcggcgc gctccgaaag tttcctttta tggcgaggcg      780

gcggcggcgg cggccctata aaaagcgaag cgcgcggcgg gcggggagtc gctgcgacgc      840

tgccttcgcc ccgtgccccg ctccgccgcc gcctcgcgcc gcccgccccg gctctgactg      900

accgcgttac tcccacaggt gagcgggcgg gacggccctt ctcctccggg ctgtaattag      960

cgcttggttt aatgacggct tgtttctttt ctgtggctgc gtgaaagcct tgaggggctc     1020

cgggagggcc ctttgtgcgg ggggagcggc tcggggggtg cgtgcgtgtg tgtgtgcgtg     1080

gggagcgccg cgtgcggctc cgcgctgccc ggcggctgtg agcgctgcgg gcgcggcgcg     1140

gggctttgtg cgctccgcag tgtgcgcgag gggagcgcgg ccgggggcgg tgccccgcgg     1200

tgcggggggg gctgcgaggg gaacaaaggc tgcgtgcggg gtgtgtgcgt gggggggtga     1260

gcagggggtg tgggcgcgtc ggtcgggctg caaccccccc tgcacccccc tccccgagtt     1320

gctgagcacg gcccggcttc gggtgcgggg ctccgtacgg ggcgtggcgc ggggctcgcc     1380

gtgccgggcg gggggtggcg gcaggtgggg gtgccgggcg gggcggggcc gcctcgggcc     1440

ggggagggct cgggggaggg gcgcggcggc ccccggagcg ccggcggctg tcgaggcgcg     1500

gcgagccgca gccattgcct tttatggtaa tcgtgcgaga gggcgcaggg acttcctttg     1560

tcccaaatct gtgcggagcc gaaatctggg aggcgccgcc gcaccccctc tagcgggcgc     1620

ggggcgaagc ggtgcggcgc cggcaggaag gaaatgggcg gggagggcct tcgtgcgtcg     1680

ccgcgccgcc gtccccttct ccctctccag cctcggggct gtccgcgggg ggacggctgc     1740

cttcgggggg gacggggcag ggcggggttc ggcttctggc gtgtgaccgg cggctctaga     1800

caattgtact aaccttcttc tctttcctct cctgacaggt tggtgtacac tagcggccgc     1860

atgccaccta atataaactg gaaagaaata atgaaagttg acccagatga cctgccccgt     1920

caagaagaac tggcagataa tttattgatt tccttatcca aggtggaagt aaatgagcta     1980

aaaagtgaaa agcaagaaaa tgtgatacac cttttcagaa ttactcagtc actaatgaag     2040

atgaaagctc aagaagtgga gctggctttg gaagaagtag aaaaagctgg agaagaacaa     2100

gcaaaatttg aaaatcaatt aaaaactaaa gtaatgaaac tggaaaatga actggagatg     2160

gctcagcagt ctgcaggtgg acgagatact cggtttttac gtaatgaaat ttgccaactt     2220

gaaaaacaat tagaacaaaa agatagagaa ttggaggaca tggaaaagga gttggagaaa     2280

gagaagaaag ttaatgagca attggctctt cgaaatgagg aggcagaaaa tgaaaacagc     2340

aaattaagaa gagagaacaa acgtctaaag aaaaagaatg aacaactttg tcaggatatt     2400

attgactacc agaaacaaat agattcacag aaagaaacac ttttatcaag aagaggggaa     2460

gacagtgact accgatcaca gttgtctaaa aaaaactatg agcttatcca atatcttgat     2520

gaaattcaga ctttaacaga agctaatgag aaaattgaag ttcagaatca agaaatgaga     2580

aaaaatttag aagagtctgt acaggaaatg gagaagatga ctgatgaata taatagaatg     2640

aaagctattg tgcatcagac agataatgta atagatcagt taaaaaaaga aaacgatcat     2700

tatcaacttc aagtgcagga gcttacagat cttctgaaat caaaaaatga agaagatgat     2760

ccaattatgg tagctgtcaa tgcaaaagta gaagaatgga agctaatttt gtcttctaaa     2820

gatgatgaaa ttattgagta tcagcaaatg ttacataacc taagggagaa acttaagaat     2880

gctcagcttg atgctgataa aagtaatgtt atggctctac agcagggtat acaggaacga     2940

gacagtcaaa ttaagatgct caccgaacaa gtagaacaat atacaaaaga aatggaaaag     3000

aatacttgta ttattgaaga tttgaaaaat gagctccaaa gaaacaaagg tgcttcaacc     3060

ctttctcaac agactcatat gaaaattcag tcaacgttag acattttaaa agagaaaact     3120

aaagaggctg agagaacagc tgaactggct gaggctgatg ctagggaaaa ggataaagaa     3180

ttagttgagg ctctgaagag gttaaaagat tatgaatcgg gagtatatgg tttagaagat     3240

gctgtcgttg aaataaagaa ttgtaaaaac caaattaaaa taagagatcg agagattgaa     3300

atattaacaa aggaaatcaa taaacttgaa ttgaagatca gtgatttcct tgatgaaaat     3360

gaggcactta gagagcgtgt gggccttgaa ccaaagacaa tgattgattt aactgaattt     3420

agaaatagca aacacttaaa acagcagcag tacagagctg aaaaccagat tcttttgaaa     3480

gagattgaaa gtctagagga agaacgactt gatctgaaaa aaaaaattcg tcaaatggct     3540

caagaaagag gaaaaagaag tgcaacttca ggattaacca ctgaggacct gaacctaact     3600

gaaaacattt ctcaaggaga tagaataagt gaaagaaaat tggatttatt gagcctcaaa     3660

aatatgagtg aagcacaatc aaagaatgaa tttctttcaa gagaactaat tgaaaaagaa     3720

agagatttag aaaggagtag gacagtgata gccaaatttc agaataaatt aaaagaatta     3780

gttgaagaaa ataagcaact tgaagaaggt atgaaagaaa tattgcaagc aattaaggaa     3840

atgcagaaag atcctgatgt taaaggagga gaaacatctc taattatccc tagccttgaa     3900

agactagtta atgctataga atcaaagaat gcagaaggaa tctttgatgc gagtctgcat     3960

ttgaaagccc aagttgatca gcttaccgga agaaatgaag aattaagaca ggagctcagg     4020

gaatctcgga aagaggctat aaattattca cagcagttgg caaaagctaa tttaaagata     4080

gaccatcttg aaaaagaaac tagtctttta cgacaatcag aaggatcgaa tgttgttttt     4140

aaaggaattg acttacctga tgggatagca ccatctagtg ccagtatcat taattctcag     4200

aatgaatatt taatacattt gttacaggaa ctagaaaata aagaaaaaaa gttaaagaat     4260

ttagaagatt ctcttgaaga ttacaacaga aaatttgctg taattcgtca tcaacaaagt     4320

ttgttgtata aagaatacct aagtgaaaag gagacctgga aaacagaatc taaaacaata     4380

aaagaggaaa agagaaaact tgaggatcaa gtccaacaag atgctataaa agtaaaagaa     4440

tataataatt tgctcaatgc tcttcagatg gattcggatg aaatgaaaaa aatacttgca     4500

gaaaatagta ggaaaattac tgttttgcaa gtgaatgaaa aatcacttat aaggcaatat     4560

acaaccttag tagaattgga gcgacaactt agaaaagaaa atgagaagca aaagaatgaa     4620

ttgttgtcaa tggaggctga agtttgtgaa aaaattgggt gtttgcaaag atttaaggaa     4680

atggccattt tcaagattgc agctctccaa aaagttgtag ataatagtgt ttctttgtct     4740

gaactagaac tggctaataa acagtacaat gaactgactg ctaagtacag ggacatcttg     4800

caaaaagata atatgcttgt tcaaagaaca agtaacttgg aacacctgga ggtaagagag     4860

ctcgttgcga tattattaca gatatccagc acagtggcgg ccgctgtaat cccagcactt     4920

taggaggccg aggcgggtgg atcacgagtt caggagatcg acaccgcggt tcgaaagatc     4980

tgcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc     5040

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     5100

gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg     5160

ggaggattgg gaagacaata gcaggcatgc tggggactcg agttctacgt agataagtag     5220

catggcgggt taatcattaa ctacaaggaa cccctagtga tggagttggc cactccctct     5280

ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt     5340

gcccgggcgg cctcagtgag cgagcgagcg cgcagcctta attaacctaa ggaaaatgaa     5400

gtgaagttcc tatactttct agagaatagg aacttctata gtgagtcgaa taagggcgac     5460

acaaaattta ttctaaatgc ataataaata ctgataacat cttatagttt gtattatatt     5520

ttgtattatc gttgacatgt ataattttga tatcaaaaac tgattttccc tttattattt     5580

tcgagattta ttttcttaat tctctttaac aaactagaaa tattgtatat acaaaaaatc     5640

ataaataata gatgaatagt ttaattatag gtgttcatca atcgaaaaag caacgtatct     5700

tatttaaagt gcgttgcttt tttctcattt ataaggttaa ataattctca tatatcaagc     5760

aaagtgacag gcgcccttaa atattctgac aaatgctctt tccctaaact ccccccataa     5820

aaaaacccgc cgaagcgggt ttttacgtta tttgcggatt aacgattact cgttatcaga     5880

accgcccagg gggcccgagc ttaacctttt tatttggggg agagggaagt catgaaaaaa     5940

ctaacctttg aaattcgatc tccagcacat cagcaaaacg ctattcacgc agtacagcaa     6000

atccttccag acccaaccaa accaatcgta gtaaccattc aggaacgcaa ccgcagctta     6060

gaccaaaaca ggaagctatg ggcctgctta ggtgacgtct ctcgtcaggt tgaatggcat     6120

ggtcgctggc tggatgcaga aagctggaag tgtgtgttta ccgcagcatt aaagcagcag     6180

gatgttgttc ctaaccttgc cgggaatggc tttgtggtaa taggccagtc aaccagcagg     6240

atgcgtgtag gcgaatttgc ggagctatta gagcttatac aggcattcgg tacagagcgt     6300

ggcgttaagt ggtcagacga agcgagactg gctctggagt ggaaagcgag atggggagac     6360

agggctgcat gataaatgtc gttagtttct ccggtggcag gacgtcagca tatttgctct     6420

ggctaatgga gcaaaagcga cgggcaggta aagacgtgca ttacgttttc atggatacag     6480

gttgtgaaca tccaatgaca tatcggtttg tcagggaagt tgtgaagttc tgggatatac     6540

cgctcaccgt attgcaggtt gatatcaacc cggagcttgg acagccaaat ggttatacgg     6600

tatgggaacc aaaggatatt cagacgcgaa tgcctgttct gaagccattt atcgatatgg     6660

taaagaaata tggcactcca tacgtcggcg gcgcgttctg cactgacaga ttaaaactcg     6720

ttcccttcac caaatactgt gatgaccatt tcgggcgagg gaattacacc acgtggattg     6780

gcatcagagc tgatgaaccg aagcggctaa agccaaagcc tggaatcaga tatcttgctg     6840

aactgtcaga ctttgagaag gaagatatcc tcgcatggtg gaagcaacaa ccattcgatt     6900

tgcaaatacc ggaacatctc ggtaactgca tattctgcat taaaaaatca acgcaaaaaa     6960

tcggacttgc ctgcaaagat gaggagggat tgcagcgtgt ttttaatgag gtcatcacgg     7020

gatcccatgt gcgtgacgga catcgggaaa cgccaaagga gattatgtac cgaggaagaa     7080

tgtcgctgga cggtatcgcg aaaatgtatt cagaaaatga ttatcaagcc ctgtatcagg     7140

acatggtacg agctaaaaga ttcgataccg gctcttgttc tgagtcatgc gaaatatttg     7200

gagggcagct tgatttcgac ttcgggaggg aagctgcatg atgcgatgtt atcggtgcgg     7260

tgaatgcaaa gaagataacc gcttccgacc aaatcaacct tactggaatc gatggtgtct     7320

ccggtgtgaa agaacaccaa caggggtgtt accactaccg caggaaaagg aggacgtgtg     7380

gcgagacagc gacgaagtat caccgacata atctgcgaaa actgcaaata ccttccaacg     7440

aaacgcacca gaaataaacc caagccaatc ccaaaagaat ctgacgtaaa aaccttcaac     7500

tacacggctc acctgtggga tatccggtgg ctaagacgtc gtgcgaggaa aacaaggtga     7560

ttgaccaaaa tcgaagttac gaacaagaaa gcgtcgagcg agctttaacg tgcgctaact     7620

gcggtcagaa gctgcatgtg ctggaagttc acgtgtgtga gcactgctgc gcagaactga     7680

tgagcgatcc gaatagctcg atgcacgagg aagaagatga tggctaaacc agcgcgaaga     7740

cgatgtaaaa acgatgaatg ccgggaatgg tttcaccctg cattcgctaa tcagtggtgg     7800

tgctctccag agtgtggaac caagatagca ctcgaacgac gaagtaaaga acgcgaaaaa     7860

gcggaaaaag cagcagagaa gaaacgacga cgagaggagc agaaacagaa agataaactt     7920

aagattcgaa aactcgcctt aaagccccgc agttactgga ttaaacaagc ccaacaagcc     7980

gtaaacgcct tcatcagaga aagagaccgc gacttaccat gtatctcgtg cggaacgctc     8040

acgtctgctc agtgggatgc cggacattac cggacaactg ctgcggcacc tcaactccga     8100

tttaatgaac gcaatattca caagcaatgc gtggtgtgca accagcacaa aagcggaaat     8160

ctcgttccgt atcgcgtcga actgattagc cgcatcgggc aggaagcagt agacgaaatc     8220

gaatcaaacc ataaccgcca tcgctggact atcgaagagt gcaaggcgat caaggcagag     8280

taccaacaga aactcaaaga cctgcgaaat agcagaagtg aggccgcatg acgttctcag     8340

taaaaaccat tccagacatg ctcgttgaag catacggaaa tcagacagaa gtagcacgca     8400

gactgaaatg tagtcgcggt acggtcagaa aatacgttga tgataaagac gggaaaatgc     8460

acgccatcgt caacgacgtt ctcatggttc atcgcggatg gagtgaaaga gatgcgctat     8520

tacgaaaaaa ttgatggcag caaataccga aatatttggg tagttggcga tctgcacgga     8580

tgctacacga acctgatgaa caaactggat acgattggat tcgacaacaa aaaagacctg     8640

cttatctcgg tgggcgattt ggttgatcgt ggtgcagaga acgttgaatg cctggaatta     8700

atcacattcc cctggttcag agctgtacgt ggaaaccatg agcaaatgat gattgatggc     8760

ttatcagagc gtggaaacgt taatcactgg ctgcttaatg gcggtggctg gttctttaat     8820

ctcgattacg acaaagaaat tctggctaaa gctcttgccc ataaagcaga tgaacttccg     8880

ttaatcatcg aactggtgag caaagataaa aaatatgtta tctgccacgc cgattatccc     8940

tttgacgaat acgagtttgg aaagccagtt gatcatcagc aggtaatctg gaaccgcgaa     9000

cgaatcagca actcacaaaa cgggatcgtg aaagaaatca aaggcgcgga cacgttcatc     9060

tttggtcata cgccagcagt gaaaccactc aagtttgcca accaaatgta tatcgatacc     9120

ggcgcagtgt tctgcggaaa cctaacattg attcaggtac agggagaagg cgcatgagac     9180

tcgaaagcgt agctaaattt cattcgccaa aaagcccgat gatgagcgac tcaccacggg     9240

ccacggcttc tgactctctt tccggtactg atgtgatggc tgctatgggg atggcgcaat     9300

cacaagccgg attcggtatg gctgcattct gcggtaagca cgaactcagc cagaacgaca     9360

aacaaaaggc tatcaactat ctgatgcaat ttgcacacaa ggtatcgggg aaataccgtg     9420

gtgtggcaaa gcttgaagga aatactaagg caaaggtact gcaagtgctc gcaacattcg     9480

cttatgcgga ttattgccgt agtgccgcga cgccgggggc aagatgcaga gattgccatg     9540

gtacaggccg tgcggttgat attgccaaaa cagagctgtg ggggagagtt gtcgagaaag     9600

agtgcggaag atgcaaaggc gtcggctatt caaggatgcc agcaagcgca gcatatcgcg     9660

ctgtgacgat gctaatccca aaccttaccc aacccacctg gtcacgcact gttaagccgc     9720

tgtatgacgc tctggtggtg caatgccaca aagaagagtc aatcgcagac aacattttga     9780

atgcggtcac acgttagcag catgattgcc acggatggca acatattaac ggcatgatat     9840

tgacttattg aataaaattg ggtaaatttg actcaacgat gggttaattc gctcgttgtg     9900

gtagtgagat gaaaagaggc ggcgcttact accgattccg cctagttggt cacttcgacg     9960

tatcgtctgg aactccaacc atcgcaggca gagaggtctg caaaatgcaa tcccgaaaca    10020

gttcgcaggt aatagttaga gcctgcataa cggtttcggg attttttata tctgcacaac    10080

aggtaagagc attgagtcga taatcgtgaa gagtcggcga gcctggttag ccagtgctct    10140

ttccgttgtg ctgaattaag cgaataccgg aagcagaacc ggatcaccaa atgcgtacag    10200

gcgtcatcgc cgcccagcaa cagcacaacc caaactgagc cgtagccact gtctgtcctg    10260

aattcattag taatagttac gctgcggcct tttacacatg accttcgtga aagcgggtgg    10320

caggaggtcg cgctaacaac ctcctgccgt tttgcccgtg catatcggtc acgaacaaat    10380

ctgattacta aacacagtag cctggatttg ttctatcagt aatcgacctt attcctaatt    10440

aaatagagca aatcccctta ttgggggtaa gacatgaaga tgccagaaaa acatgacctg    10500

ttggccgcca ttctcgcggc aaaggaacaa ggcatcgggg caatccttgc gtttgcaatg    10560

gcgtaccttc gcggcagata taatggcggt gcgtttacaa aaacagtaat cgacgcaacg    10620

atgtgcgcca ttatcgcctg gttcattcgt gaccttctcg acttcgccgg actaagtagc    10680

aatctcgctt atataacgag cgtgtttatc ggctacatcg gtactgactc gattggttcg    10740

cttatcaaac gcttcgctgc taaaaaagcc ggagtagaag atggtagaaa tcaataatca    10800

acgtaaggcg ttcctcgata tgctggcgtg gtcggaggga actgataacg gacgtcagaa    10860

aaccagaaat catggttatg acgtcattgt aggcggagag ctatttactg attactccga    10920

tcaccctcgc aaacttgtca cgctaaaccc aaaactcaaa tcaacaggcg cttaagactg    10980

gccgtcgttt tacaacacag aaagagtttg tagaaacgca aaaaggccat ccgtcagggg    11040

ccttctgctt agtttgatgc ctggcagttc cctactctcg ccttccgctt cctcgctcac    11100

tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta tcagctcact caaaggcggt    11160

aatacggtta tccacagaat caggggataa cgcaggaaag aacatgtgag caaaaggcca    11220

gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc    11280

ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact    11340

ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct    11400

gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag    11460

ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca    11520

cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa    11580

cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc    11640

gaggtatgta ggcggtgcta cagagttctt gaagtggtgg gctaactacg gctacactag    11700

aagaacagta tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg    11760

tagctcttga tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca    11820

gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc    11880

tgacgctcag tggaacgacg cgcgcgtaac tcacgttaag ggattttggt catgagcttg    11940

cgccgtcccg tcaagtcagc gtaatgctct gcttttagaa aaactcatcg agcatcaaat    12000

gaaactgcaa tttattcata tcaggattat caataccata tttttgaaaa agccgtttct    12060

gtaatgaagg agaaaactca ccgaggcagt tccataggat ggcaagatcc tggtatcggt    12120

ctgcgattcc gactcgtcca acatcaatac aacctattaa tttcccctcg tcaaaaataa    12180

ggttatcaag tgagaaatca ccatgagtga cgactgaatc cggtgagaat ggcaaaagtt    12240

tatgcatttc tttccagact tgttcaacag gccagccatt acgctcgtca tcaaaatcac    12300

tcgcatcaac caaaccgtta ttcattcgtg attgcgcctg agcgaggcga aatacgcgat    12360

cgctgttaaa aggacaatta caaacaggaa tcgagtgcaa ccggcgcagg aacactgcca    12420

gcgcatcaac aatattttca cctgaatcag gatattcttc taatacctgg aacgctgttt    12480

ttccggggat cgcagtggtg agtaaccatg catcatcagg agtacggata aaatgcttga    12540

tggtcggaag tggcataaat tccgtcagcc agtttagtct gaccatctca tctgtaacat    12600

cattggcaac gctacctttg ccatgtttca gaaacaactc tggcgcatcg ggcttcccat    12660

acaagcgata gattgtcgca cctgattgcc cgacattatc gcgagcccat ttatacccat    12720

ataaatcagc atccatgttg gaatttaatc gcggcctcga cgtttcccgt tgaatatggc    12780

tcatattctt cctttttcaa tattattgaa gcatttatca gggttattgt ctcatgagcg    12840

gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggtcagtgtt acaaccaatt    12900

aaccaattct gaacattatc gcgagcccat ttatacctga atatggctca taacacccct    12960

tgtttgcctg gcggcagtag cgcggtggtc ccacctgacc ccatgccgaa ctcagaagtg    13020

aaacgccgta gcgccgatgg tagtgtgggg actccccatg cgagagtagg gaactgccag    13080

gcatcaaata aaacgaaagg ctcagtcgaa agactgggcc tttcgcccgg gctaattagg    13140

gggtgtcgcc cttattcgac tctatagtga agttcctatt ctctagaaag tataggaact    13200

tctgaagtgg ggtcgactta attaagg                                        13227


<210>  3
<211>  269
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  3

Met Ser His Ile Gln Arg Glu Thr Ser Arg Pro Arg Leu Asn Ser Asn 
1               5                   10                  15      


Met Asp Ala Asp Leu Tyr Gly Tyr Lys Trp Ala Arg Asp Asn Val Gly 
            20                  25                  30          


Gln Ser Gly Ala Thr Ile Tyr Arg Leu Tyr Gly Lys Pro Asp Ala Pro 
        35                  40                  45              


Glu Leu Phe Leu Lys His Gly Lys Gly Ser Val Ala Asn Asp Val Thr 
    50                  55                  60                  


Asp Glu Met Val Arg Leu Asn Trp Leu Thr Glu Phe Met Pro Leu Pro 
65                  70                  75                  80  


Thr Ile Lys His Phe Ile Arg Thr Pro Asp Asp Ala Trp Leu Leu Thr 
                85                  90                  95      


Thr Ala Ile Pro Gly Lys Thr Ala Phe Gln Val Leu Glu Glu Tyr Pro 
            100                 105                 110         


Asp Ser Gly Glu Asn Ile Val Asp Ala Leu Ala Val Phe Leu Arg Arg 
        115                 120                 125             


Leu His Ser Ile Pro Val Cys Asn Cys Pro Phe Asn Ser Asp Arg Val 
    130                 135                 140                 


Phe Arg Leu Ala Gln Ala Gln Ser Arg Met Asn Asn Gly Leu Val Asp 
145                 150                 155                 160 


Ala Ser Asp Phe Asp Asp Glu Arg Asn Gly Trp Pro Val Glu Gln Val 
                165                 170                 175     


Trp Lys Glu Met His Lys Leu Leu Pro Phe Ser Pro Asp Ser Val Val 
            180                 185                 190         


Thr His Gly Asp Phe Ser Leu Asp Asn Leu Ile Phe Asp Glu Gly Lys 
        195                 200                 205             


Leu Ile Gly Cys Ile Asp Val Gly Arg Val Gly Ile Ala Asp Arg Tyr 
    210                 215                 220                 


Gln Asp Leu Ala Ile Leu Trp Asn Cys Leu Gly Glu Phe Ser Pro Ser 
225                 230                 235                 240 


Leu Gln Lys Arg Leu Phe Gln Lys Tyr Gly Ile Asp Asn Pro Asp Met 
                245                 250                 255     


Asn Lys Leu Gln Phe His Leu Met Leu Asp Glu Phe Phe 
            260                 265                 


<210>  4
<211>  269
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  4

Met Ser His Ile Gln Arg Glu Thr Ser Arg Pro Arg Leu Asn Ser Asn 
1               5                   10                  15      


Met Asp Ala Asp Leu Tyr Gly Tyr Lys Trp Ala Arg Asp Asn Val Gly 
            20                  25                  30          


Gln Ser Gly Ala Thr Ile Tyr Arg Leu Tyr Gly Lys Pro Asp Ala Pro 
        35                  40                  45              


Glu Leu Phe Leu Lys His Gly Lys Gly Ser Val Ala Asn Asp Val Thr 
    50                  55                  60                  


Asp Glu Met Val Arg Leu Asn Trp Leu Thr Glu Phe Met Pro Leu Pro 
65                  70                  75                  80  


Thr Ile Lys His Phe Ile Arg Thr Pro Asp Asp Ala Trp Leu Leu Thr 
                85                  90                  95      


Thr Ala Ile Pro Gly Lys Thr Ala Phe Gln Val Leu Glu Glu Tyr Pro 
            100                 105                 110         


Asp Ser Gly Glu Asn Ile Val Asp Ala Leu Ala Val Phe Leu Arg Arg 
        115                 120                 125             


Leu His Ser Ile Pro Val Cys Asn Cys Pro Phe Asn Ser Asp Arg Val 
    130                 135                 140                 


Phe Arg Leu Ala Gln Ala Gln Ser Arg Met Asn Asn Gly Leu Val Asp 
145                 150                 155                 160 


Ala Ser Asp Phe Asp Asp Glu Arg Asn Gly Trp Pro Val Glu Gln Val 
                165                 170                 175     


Trp Lys Glu Met His Lys Leu Leu Pro Phe Ser Pro Asp Ser Val Val 
            180                 185                 190         


Thr His Gly Asp Phe Ser Leu Asp Asn Leu Ile Phe Asp Glu Gly Lys 
        195                 200                 205             


Leu Ile Gly Cys Ile Asp Val Gly Arg Val Gly Ile Ala Asp Arg Tyr 
    210                 215                 220                 


Gln Asp Leu Ala Ile Leu Trp Asn Cys Leu Gly Glu Phe Ser Pro Ser 
225                 230                 235                 240 


Leu Gln Lys Arg Leu Phe Gln Lys Tyr Gly Ile Asp Asn Pro Asp Met 
                245                 250                 255     


Asn Lys Leu Gln Phe His Leu Met Leu Asp Glu Phe Phe 
            260                 265                 


<210>  5
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' splice site with spacer

<400>  5
gtaagagagc tcgttgcgat attat                                             25


<210>  6
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  splice site for a 3'RTM

<400>  6
tactaactgg tacctcttct tttttttctg cag                                    33


<210>  7
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polypyrrimidine tract for the 3' RTM

<400>  7
tggtacctct tctttttttt ctg                                               23


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer for a 5' RTM

<400>  8
agatctcgtt gcgatattat                                                   20


<210>  9
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer for a 3' RTM

<400>  9
gagaacatta ttatagcgtt gctcgag                                           27


<210>  10
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' RTM Spacer sequence

<400>  10
gagaacatta ttatagcgtt gctcgag                                           27


<210>  11
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' RTM Polypyrimidine tract

<400>  11
tggtacctct tctttttttt ctg                                               23


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'RTM spacer sequence

<400>  12
agagctcgtt gcgatattat                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3'RTM spacer sequence

<400>  13
agagctcgtt gcgatattat                                                   20


<210>  14
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3 'RTM Polypyrrimidine tract

<400>  14
tggtacctct tctttttttt ctg                                               23


