                         SEQUENCE LISTING

<110>  CSL Limited
 
<120>  CD131 binding proteins and uses thereof

<130>  524225

<160>  197   

<170>  PatentIn version 3.5

<210>  1
<211>  897
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Val Leu Ala Gln Gly Leu Leu Ser Met Ala Leu Leu Ala Leu Cys 
1               5                   10                  15      


Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
            20                  25                  30          


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
        35                  40                  45              


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
    50                  55                  60                  


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
65                  70                  75                  80  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
                85                  90                  95      


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
            100                 105                 110         


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
        115                 120                 125             


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
    130                 135                 140                 


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
145                 150                 155                 160 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
                165                 170                 175     


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
            180                 185                 190         


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
        195                 200                 205             


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
    210                 215                 220                 


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
225                 230                 235                 240 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
                245                 250                 255     


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
            260                 265                 270         


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
        275                 280                 285             


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
    290                 295                 300                 


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
305                 310                 315                 320 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
                325                 330                 335     


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
            340                 345                 350         


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
        355                 360                 365             


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
    370                 375                 380                 


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
385                 390                 395                 400 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
                405                 410                 415     


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
            420                 425                 430         


Ser Trp Asp Thr Glu Ser Val Leu Pro Met Trp Val Leu Ala Leu Ile 
        435                 440                 445             


Val Ile Phe Leu Thr Ile Ala Val Leu Leu Ala Leu Arg Phe Cys Gly 
    450                 455                 460                 


Ile Tyr Gly Tyr Arg Leu Arg Arg Lys Trp Glu Glu Lys Ile Pro Asn 
465                 470                 475                 480 


Pro Ser Lys Ser His Leu Phe Gln Asn Gly Ser Ala Glu Leu Trp Pro 
                485                 490                 495     


Pro Gly Ser Met Ser Ala Phe Thr Ser Gly Ser Pro Pro His Gln Gly 
            500                 505                 510         


Pro Trp Gly Ser Arg Phe Pro Glu Leu Glu Gly Val Phe Pro Val Gly 
        515                 520                 525             


Phe Gly Asp Ser Glu Val Ser Pro Leu Thr Ile Glu Asp Pro Lys His 
    530                 535                 540                 


Val Cys Asp Pro Pro Ser Gly Pro Asp Thr Thr Pro Ala Ala Ser Asp 
545                 550                 555                 560 


Leu Pro Thr Glu Gln Pro Pro Ser Pro Gln Pro Gly Pro Pro Ala Ala 
                565                 570                 575     


Ser His Thr Pro Glu Lys Gln Ala Ser Ser Phe Asp Phe Asn Gly Pro 
            580                 585                 590         


Tyr Leu Gly Pro Pro His Ser Arg Ser Leu Pro Asp Ile Leu Gly Gln 
        595                 600                 605             


Pro Glu Pro Pro Gln Glu Gly Gly Ser Gln Lys Ser Pro Pro Pro Gly 
    610                 615                 620                 


Ser Leu Glu Tyr Leu Cys Leu Pro Ala Gly Gly Gln Val Gln Leu Val 
625                 630                 635                 640 


Pro Leu Ala Gln Ala Met Gly Pro Gly Gln Ala Val Glu Val Glu Arg 
                645                 650                 655     


Arg Pro Ser Gln Gly Ala Ala Gly Ser Pro Ser Leu Glu Ser Gly Gly 
            660                 665                 670         


Gly Pro Ala Pro Pro Ala Leu Gly Pro Arg Val Gly Gly Gln Asp Gln 
        675                 680                 685             


Lys Asp Ser Pro Val Ala Ile Pro Met Ser Ser Gly Asp Thr Glu Asp 
    690                 695                 700                 


Pro Gly Val Ala Ser Gly Tyr Val Ser Ser Ala Asp Leu Val Phe Thr 
705                 710                 715                 720 


Pro Asn Ser Gly Ala Ser Ser Val Ser Leu Val Pro Ser Leu Gly Leu 
                725                 730                 735     


Pro Ser Asp Gln Thr Pro Ser Leu Cys Pro Gly Leu Ala Ser Gly Pro 
            740                 745                 750         


Pro Gly Ala Pro Gly Pro Val Lys Ser Gly Phe Glu Gly Tyr Val Glu 
        755                 760                 765             


Leu Pro Pro Ile Glu Gly Arg Ser Pro Arg Ser Pro Arg Asn Asn Pro 
    770                 775                 780                 


Val Pro Pro Glu Ala Lys Ser Pro Val Leu Asn Pro Gly Glu Arg Pro 
785                 790                 795                 800 


Ala Asp Val Ser Pro Thr Ser Pro Gln Pro Glu Gly Leu Leu Val Leu 
                805                 810                 815     


Gln Gln Val Gly Asp Tyr Cys Phe Leu Pro Gly Leu Gly Pro Gly Pro 
            820                 825                 830         


Leu Ser Leu Arg Ser Lys Pro Ser Ser Pro Gly Pro Gly Pro Glu Ile 
        835                 840                 845             


Lys Asn Leu Asp Gln Ala Phe Gln Val Lys Lys Pro Pro Gly Gln Ala 
    850                 855                 860                 


Val Pro Gln Val Pro Val Ile Gln Leu Phe Lys Ala Leu Lys Gln Gln 
865                 870                 875                 880 


Asp Tyr Leu Ser Leu Pro Pro Trp Glu Val Asn Lys Pro Gly Glu Val 
                885                 890                 895     


Cys 
    


<210>  2
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Leu Leu Trp Leu Thr Leu Leu Leu Ile Ala Leu Pro Cys Leu 
1               5                   10                  15      


Leu Gln Thr Lys Glu Asp Pro Asn Pro Pro Ile Thr Asn Leu Arg Met 
            20                  25                  30          


Lys Ala Lys Ala Gln Gln Leu Thr Trp Asp Leu Asn Arg Asn Val Thr 
        35                  40                  45              


Asp Ile Glu Cys Val Lys Asp Ala Asp Tyr Ser Met Pro Ala Val Asn 
    50                  55                  60                  


Asn Ser Tyr Cys Gln Phe Gly Ala Ile Ser Leu Cys Glu Val Thr Asn 
65                  70                  75                  80  


Tyr Thr Val Arg Val Ala Asn Pro Pro Phe Ser Thr Trp Ile Leu Phe 
                85                  90                  95      


Pro Glu Asn Ser Gly Lys Pro Trp Ala Gly Ala Glu Asn Leu Thr Cys 
            100                 105                 110         


Trp Ile His Asp Val Asp Phe Leu Ser Cys Ser Trp Ala Val Gly Pro 
        115                 120                 125             


Gly Ala Pro Ala Asp Val Gln Tyr Asp Leu Tyr Leu Asn Val Ala Asn 
    130                 135                 140                 


Arg Arg Gln Gln Tyr Glu Cys Leu His Tyr Lys Thr Asp Ala Gln Gly 
145                 150                 155                 160 


Thr Arg Ile Gly Cys Arg Phe Asp Asp Ile Ser Arg Leu Ser Ser Gly 
                165                 170                 175     


Ser Gln Ser Ser His Ile Leu Val Arg Gly Arg Ser Ala Ala Phe Gly 
            180                 185                 190         


Ile Pro Cys Thr Asp Lys Phe Val Val Phe Ser Gln Ile Glu Ile Leu 
        195                 200                 205             


Thr Pro Pro Asn Met Thr Ala Lys Cys Asn Lys Thr His Ser Phe Met 
    210                 215                 220                 


His Trp Lys Met Arg Ser His Phe Asn Arg Lys Phe Arg Tyr Glu Leu 
225                 230                 235                 240 


Gln Ile Gln Lys Arg Met Gln Pro Val Ile Thr Glu Gln Val Arg Asp 
                245                 250                 255     


Arg Thr Ser Phe Gln Leu Leu Asn Pro Gly Thr Tyr Thr Val Gln Ile 
            260                 265                 270         


Arg Ala Arg Glu Arg Val Tyr Glu Phe Leu Ser Ala Trp Ser Thr Pro 
        275                 280                 285             


Gln Arg Phe Glu Cys Asp Gln Glu Glu Gly Ala Asn Thr Arg Ala Trp 
    290                 295                 300                 


Arg Thr Ser Leu Leu Ile Ala Leu Gly Thr Leu Leu Ala Leu Val Cys 
305                 310                 315                 320 


Val Phe Val Ile Cys Arg Arg Tyr Leu Val Met Gln Arg Leu Phe Pro 
                325                 330                 335     


Arg Ile Pro His Met Lys Asp Pro Ile Gly Asp Ser Phe Gln Asn Asp 
            340                 345                 350         


Lys Leu Val Val Trp Glu Ala Gly Lys Ala Gly Leu Glu Glu Cys Leu 
        355                 360                 365             


Val Thr Glu Val Gln Val Val Gln Lys Thr 
    370                 375             


<210>  3
<211>  836
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Arg Leu Gly Asn Cys Ser Leu Thr Trp Ala Ala Leu Ile Ile 
1               5                   10                  15      


Leu Leu Leu Pro Gly Ser Leu Glu Glu Cys Gly His Ile Ser Val Ser 
            20                  25                  30          


Ala Pro Ile Val His Leu Gly Asp Pro Ile Thr Ala Ser Cys Ile Ile 
        35                  40                  45              


Lys Gln Asn Cys Ser His Leu Asp Pro Glu Pro Gln Ile Leu Trp Arg 
    50                  55                  60                  


Leu Gly Ala Glu Leu Gln Pro Gly Gly Arg Gln Gln Arg Leu Ser Asp 
65                  70                  75                  80  


Gly Thr Gln Glu Ser Ile Ile Thr Leu Pro His Leu Asn His Thr Gln 
                85                  90                  95      


Ala Phe Leu Ser Cys Cys Leu Asn Trp Gly Asn Ser Leu Gln Ile Leu 
            100                 105                 110         


Asp Gln Val Glu Leu Arg Ala Gly Tyr Pro Pro Ala Ile Pro His Asn 
        115                 120                 125             


Leu Ser Cys Leu Met Asn Leu Thr Thr Ser Ser Leu Ile Cys Gln Trp 
    130                 135                 140                 


Glu Pro Gly Pro Glu Thr His Leu Pro Thr Ser Phe Thr Leu Lys Ser 
145                 150                 155                 160 


Phe Lys Ser Arg Gly Asn Cys Gln Thr Gln Gly Asp Ser Ile Leu Asp 
                165                 170                 175     


Cys Val Pro Lys Asp Gly Gln Ser His Cys Cys Ile Pro Arg Lys His 
            180                 185                 190         


Leu Leu Leu Tyr Gln Asn Met Gly Ile Trp Val Gln Ala Glu Asn Ala 
        195                 200                 205             


Leu Gly Thr Ser Met Ser Pro Gln Leu Cys Leu Asp Pro Met Asp Val 
    210                 215                 220                 


Val Lys Leu Glu Pro Pro Met Leu Arg Thr Met Asp Pro Ser Pro Glu 
225                 230                 235                 240 


Ala Ala Pro Pro Gln Ala Gly Cys Leu Gln Leu Cys Trp Glu Pro Trp 
                245                 250                 255     


Gln Pro Gly Leu His Ile Asn Gln Lys Cys Glu Leu Arg His Lys Pro 
            260                 265                 270         


Gln Arg Gly Glu Ala Ser Trp Ala Leu Val Gly Pro Leu Pro Leu Glu 
        275                 280                 285             


Ala Leu Gln Tyr Glu Leu Cys Gly Leu Leu Pro Ala Thr Ala Tyr Thr 
    290                 295                 300                 


Leu Gln Ile Arg Cys Ile Arg Trp Pro Leu Pro Gly His Trp Ser Asp 
305                 310                 315                 320 


Trp Ser Pro Ser Leu Glu Leu Arg Thr Thr Glu Arg Ala Pro Thr Val 
                325                 330                 335     


Arg Leu Asp Thr Trp Trp Arg Gln Arg Gln Leu Asp Pro Arg Thr Val 
            340                 345                 350         


Gln Leu Phe Trp Lys Pro Val Pro Leu Glu Glu Asp Ser Gly Arg Ile 
        355                 360                 365             


Gln Gly Tyr Val Val Ser Trp Arg Pro Ser Gly Gln Ala Gly Ala Ile 
    370                 375                 380                 


Leu Pro Leu Cys Asn Thr Thr Glu Leu Ser Cys Thr Phe His Leu Pro 
385                 390                 395                 400 


Ser Glu Ala Gln Glu Val Ala Leu Val Ala Tyr Asn Ser Ala Gly Thr 
                405                 410                 415     


Ser Arg Pro Thr Pro Val Val Phe Ser Glu Ser Arg Gly Pro Ala Leu 
            420                 425                 430         


Thr Arg Leu His Ala Met Ala Arg Asp Pro His Ser Leu Trp Val Gly 
        435                 440                 445             


Trp Glu Pro Pro Asn Pro Trp Pro Gln Gly Tyr Val Ile Glu Trp Gly 
    450                 455                 460                 


Leu Gly Pro Pro Ser Ala Ser Asn Ser Asn Lys Thr Trp Arg Met Glu 
465                 470                 475                 480 


Gln Asn Gly Arg Ala Thr Gly Phe Leu Leu Lys Glu Asn Ile Arg Pro 
                485                 490                 495     


Phe Gln Leu Tyr Glu Ile Ile Val Thr Pro Leu Tyr Gln Asp Thr Met 
            500                 505                 510         


Gly Pro Ser Gln His Val Tyr Ala Tyr Ser Gln Glu Met Ala Pro Ser 
        515                 520                 525             


His Ala Pro Glu Leu His Leu Lys His Ile Gly Lys Thr Trp Ala Gln 
    530                 535                 540                 


Leu Glu Trp Val Pro Glu Pro Pro Glu Leu Gly Lys Ser Pro Leu Thr 
545                 550                 555                 560 


His Tyr Thr Ile Phe Trp Thr Asn Ala Gln Asn Gln Ser Phe Ser Ala 
                565                 570                 575     


Ile Leu Asn Ala Ser Ser Arg Gly Phe Val Leu His Gly Leu Glu Pro 
            580                 585                 590         


Ala Ser Leu Tyr His Ile His Leu Met Ala Ala Ser Gln Ala Gly Ala 
        595                 600                 605             


Thr Asn Ser Thr Val Leu Thr Leu Met Thr Leu Thr Pro Glu Gly Ser 
    610                 615                 620                 


Glu Leu His Ile Ile Leu Gly Leu Phe Gly Leu Leu Leu Leu Leu Thr 
625                 630                 635                 640 


Cys Leu Cys Gly Thr Ala Trp Leu Cys Cys Ser Pro Asn Arg Lys Asn 
                645                 650                 655     


Pro Leu Trp Pro Ser Val Pro Asp Pro Ala His Ser Ser Leu Gly Ser 
            660                 665                 670         


Trp Val Pro Thr Ile Met Glu Glu Asp Ala Phe Gln Leu Pro Gly Leu 
        675                 680                 685             


Gly Thr Pro Pro Ile Thr Lys Leu Thr Val Leu Glu Glu Asp Glu Lys 
    690                 695                 700                 


Lys Pro Val Pro Trp Glu Ser His Asn Ser Ser Glu Thr Cys Gly Leu 
705                 710                 715                 720 


Pro Thr Leu Val Gln Thr Tyr Val Leu Gln Gly Asp Pro Arg Ala Val 
                725                 730                 735     


Ser Thr Gln Pro Gln Ser Gln Ser Gly Thr Ser Asp Gln Val Leu Tyr 
            740                 745                 750         


Gly Gln Leu Leu Gly Ser Pro Thr Ser Pro Gly Pro Gly His Tyr Leu 
        755                 760                 765             


Arg Cys Asp Ser Thr Gln Pro Leu Leu Ala Gly Leu Thr Pro Ser Pro 
    770                 775                 780                 


Lys Ser Tyr Glu Asn Leu Trp Phe Gln Ala Ser Pro Leu Gly Thr Leu 
785                 790                 795                 800 


Val Thr Pro Ala Pro Ser Gln Glu Asp Asp Cys Val Phe Gly Pro Leu 
                805                 810                 815     


Leu Asn Phe Pro Leu Leu Gln Gly Ile Arg Val His Gly Met Glu Ala 
            820                 825                 830         


Leu Gly Ser Phe 
        835     


<210>  4
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Asn Asp Glu His 
                325                 330                 335     


Lys Pro Leu Arg Glu Trp Phe Val Ile Val Ile Met Ala Thr Ile Cys 
            340                 345                 350         


Phe Ile Leu Leu Ile Leu Ser Leu Ile Cys Lys Ile Cys His Leu Trp 
        355                 360                 365             


Ile Lys Leu Phe Pro Pro Ile Pro Ala Pro Lys Ser Asn Ile Lys Asp 
    370                 375                 380                 


Leu Phe Val Thr Thr Asn Tyr Glu Lys Ala Gly Ser Ser Glu Thr Glu 
385                 390                 395                 400 


Ile Glu Val Ile Cys Tyr Ile Glu Lys Pro Gly Val Glu Thr Leu Glu 
                405                 410                 415     


Asp Ser Val Phe 
            420 


<210>  5
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL chain of antibody 9A2

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


<210>  6
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL chain of antibody 9A2-VR1

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Pro Phe 
            20                  25                  30          


Met Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


<210>  7
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL chain of antibody 9A2-VR2

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Gln Arg Pro Phe 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


<210>  8
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL chain of antibody 9A2-VR3

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Leu Arg Pro Phe 
            20                  25                  30          


Val Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


<210>  9
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL chain of antibody 9A2-VR4

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Pro Phe 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


<210>  10
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL chain of antibody 9A2-VR5

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Pro Phe 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


<210>  11
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL chain of antibody 9A2-VR6

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Arg Pro Phe 
            20                  25                  30          


Val Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


<210>  12
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL chain of antibody 9A2-VR8

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Arg Pro Phe 
            20                  25                  30          


Ile Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


<210>  13
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL chain of antibody 9A2-VR9

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Pro Phe 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


<210>  14
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL chain of antibody 9A2-VR11

<400>  14

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Arg Pro Phe 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


<210>  15
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL chain of antibody 9A2-VR12

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Pro Phe 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


<210>  16
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL chain of antibody 9A2-VR13

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Lys Pro Val Leu Asp Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


<210>  17
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL chain of antibody 9A2-VR14

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Lys Pro Val Phe Asp Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


<210>  18
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL chain of antibody 9A2-VR16

<400>  18

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Ile Pro Val Leu Gly Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


<210>  19
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL chain of antibody 9A2-VR19

<400>  19

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Ile Pro Ile Leu Gly Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


<210>  20
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2

<400>  20

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  21
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR20

<400>  21

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn His Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  22
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR21

<400>  22

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Met His Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  23
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR22

<400>  23

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gln Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  24
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR23

<400>  24

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  25
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24

<400>  25

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  26
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR26

<400>  26

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ile His Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  27
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR27

<400>  27

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr His Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  28
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR28

<400>  28

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Val His Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  29
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR31

<400>  29

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ala Gln Trp Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  30
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR32

<400>  30

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Val Arg Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  31
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR33

<400>  31

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Ser Gly Trp Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  32
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR34

<400>  32

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser His Phe Pro Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  33
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR35

<400>  33

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Phe Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  34
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR36

<400>  34

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Gly Asp Lys Arg Gln Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  35
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR37

<400>  35

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Met Trp Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  36
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR38

<400>  36

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Met Gly Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  37
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39

<400>  37

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  38
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR40

<400>  38

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Tyr Gly Ile Gln Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  39
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR41

<400>  39

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Lys Gly Trp Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  40
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR42

<400>  40

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Gly Asp Ile Arg Gln Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  41
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR43

<400>  41

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Ser Asp His Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  42
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR44

<400>  42

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser His Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  43
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR45

<400>  43

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Ser Asp Asn Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  44
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR46

<400>  44

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Ser Asp His Phe Arg Glu Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  45
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR47

<400>  45

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Ser Asp His Phe Ser Pro Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  46
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR48

<400>  46

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Ser Asp His Phe Lys Pro Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  47
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR49

<400>  47

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Ser Asp His Phe Asn Pro Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  48
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR50

<400>  48

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Ser Asp His Phe Ala Pro Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  49
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.04

<400>  49

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile His Thr His Arg His Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  50
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.07

<400>  50

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile His Thr His Arg Asn Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  51
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.10

<400>  51

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile His Thr Gly Ser Gln Trp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  52
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.12

<400>  52

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile His Thr His Tyr Gln Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  53
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.19

<400>  53

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile His Thr Gln Ser Lys Trp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  54
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.24

<400>  54

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Thr Asp Gly Thr Trp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  55
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.76

<400>  55

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gln Thr His Gly Val Trp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  56
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.78

<400>  56

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile His Thr His Arg Asn Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  57
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.81

<400>  57

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile His Thr His Arg Asn Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  58
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.82

<400>  58

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Lys His Gly Gly Arg Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  59
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.84

<400>  59

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile His Thr His Arg Pro Trp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  60
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.87

<400>  60

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile His Thr His Ser Asp Trp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  61
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.91

<400>  61

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile His Thr His Arg Gln Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  62
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.93

<400>  62

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Asn Glu Asn Gly Trp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  63
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.27

<400>  63

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Pro Tyr Tyr His Gln Lys Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  64
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.29

<400>  64

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Pro Tyr Tyr Asn Tyr Lys Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  65
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.30

<400>  65

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Pro Tyr Tyr Asn Arg Arg Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  66
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.33

<400>  66

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Pro Tyr Tyr Asn His Lys Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  67
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.44

<400>  67

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Pro Tyr Tyr His Pro Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  68
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.97

<400>  68

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Pro Tyr Tyr Ser Leu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  69
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.98

<400>  69

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Pro His Tyr Asn Ser Val Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  70
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.102

<400>  70

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Pro Phe Tyr Asn Ser Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  71
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.107

<400>  71

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Pro Tyr Tyr Asn Pro Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  72
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.110

<400>  72

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Pro Tyr Tyr Asn Asn His Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  73
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.111

<400>  73

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Pro Met Tyr Asn Pro His Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  74
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.55

<400>  74

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Thr Tyr Tyr Asn Pro Ser Val 
    50                  55                  60                  


Lys Asn Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  75
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.56

<400>  75

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Thr Tyr Tyr Asn Pro Ala Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  76
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.57

<400>  76

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Thr Tyr Tyr Asn Pro Lys Val 
    50                  55                  60                  


Lys His Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  77
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.122

<400>  77

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Thr Tyr Tyr Asn Ser Glu Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  78
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.124

<400>  78

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Thr Tyr Tyr Thr Pro Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  79
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR24.131

<400>  79

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Thr Tyr Tyr Asn Pro Ser Val 
    50                  55                  60                  


Met Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  80
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.01

<400>  80

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Phe Trp Phe 
            20                  25                  30          


His His Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  81
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.02

<400>  81

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Tyr Trp Tyr 
            20                  25                  30          


His Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  82
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.04

<400>  82

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Phe 
            20                  25                  30          


Gln His Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  83
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.05

<400>  83

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Phe 
            20                  25                  30          


His Thr Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  84
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.06

<400>  84

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gln Trp Tyr 
            20                  25                  30          


His Tyr Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  85
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.11

<400>  85

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gln Glu Phe 
            20                  25                  30          


His Thr Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  86
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.12

<400>  86

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Phe Trp Phe 
            20                  25                  30          


Asn Thr Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  87
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.16

<400>  87

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gln Trp Phe 
            20                  25                  30          


Asn Ile Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  88
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.17

<400>  88

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Phe Tyr 
            20                  25                  30          


His Lys Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  89
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.18

<400>  89

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Gly Tyr 
            20                  25                  30          


Val Trp Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  90
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.19

<400>  90

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gln Tyr Phe 
            20                  25                  30          


Asn Val Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  91
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.21

<400>  91

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gln His Tyr 
            20                  25                  30          


His Thr Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  92
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.22

<400>  92

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gln Trp Tyr 
            20                  25                  30          


His Val Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  93
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.23

<400>  93

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe His His Tyr 
            20                  25                  30          


His Thr Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  94
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.24

<400>  94

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe His His Phe 
            20                  25                  30          


His Val Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  95
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.97

<400>  95

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Phe 
            20                  25                  30          


His Phe Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  96
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.98

<400>  96

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu His Tyr 
            20                  25                  30          


His Thr Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  97
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.102

<400>  97

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gln Trp Phe 
            20                  25                  30          


His Tyr Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  98
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.103

<400>  98

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gln His Phe 
            20                  25                  30          


His Trp Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  99
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.105

<400>  99

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Tyr Tyr 
            20                  25                  30          


His Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  100
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.109

<400>  100

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Met Trp Tyr 
            20                  25                  30          


His His Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  101
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.110

<400>  101

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Val Trp Tyr 
            20                  25                  30          


His His Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  102
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.111

<400>  102

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Phe 
            20                  25                  30          


His Phe Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  103
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.112

<400>  103

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Tyr Tyr 
            20                  25                  30          


His Gln Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  104
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.116

<400>  104

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Phe 
            20                  25                  30          


Val Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  105
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.27

<400>  105

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Thr Ser Phe Met Trp Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  106
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.28

<400>  106

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Gly Ala Pro Met Trp Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  107
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.46

<400>  107

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Asp Val Asp Phe Gly Trp Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  108
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.122

<400>  108

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Gly Phe Phe Glu Tyr Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  109
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.139

<400>  109

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Pro Arg Trp Glu Trp Asn Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  110
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.140

<400>  110

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Tyr Ser Glu Met Trp Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  111
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.148

<400>  111

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr His Val Ala Gln Glu Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  112
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.162

<400>  112

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Pro Gln Met Ala Gln Glu Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  113
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.77

<400>  113

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Gln Trp Pro Met 
    50                  55                  60                  


Asn Lys Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  114
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.93

<400>  114

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Asn Pro Ala Trp 
    50                  55                  60                  


Lys Lys Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  115
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.174

<400>  115

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Arg Asp His 
    50                  55                  60                  


Lys Lys Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  116
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain of antibody 9A2-VR39.177

<400>  116

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Leu Glu Tyr 
    50                  55                  60                  


Lys Lys Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  117
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  117

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Ala Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  118
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  118

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Ala Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  119
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  119

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Ala Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  120
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  120

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Ala Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  121
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  121

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Thr Ala His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  122
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  122

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser Ala Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  123
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  123

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ala Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  124
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  124

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Ala Val Val Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  125
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  125

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Ala Val Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  126
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  126

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Ala Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  127
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  127

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Val Ala Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  128
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  128

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Val Thr Ala Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  129
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  129

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Ala Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  130
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  130

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Ala Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  131
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  131

Met Val Leu Ala Gln Gly Leu Leu Ser Met Ala Leu Leu Ala Leu Cys 
1               5                   10                  15      


Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
            20                  25                  30          


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
        35                  40                  45              


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
    50                  55                  60                  


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
65                  70                  75                  80  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
                85                  90                  95      


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
            100                 105                 110         


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
        115                 120                 125             


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
    130                 135                 140                 


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
145                 150                 155                 160 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
                165                 170                 175     


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
            180                 185                 190         


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
        195                 200                 205             


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
    210                 215                 220                 


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
225                 230                 235                 240 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
                245                 250                 255     


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
            260                 265                 270         


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
        275                 280                 285             


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
    290                 295                 300                 


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
305                 310                 315                 320 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
                325                 330                 335     


Asn Ala Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
            340                 345                 350         


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
        355                 360                 365             


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
    370                 375                 380                 


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
385                 390                 395                 400 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
                405                 410                 415     


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
            420                 425                 430         


Ser Trp Asp Thr Glu Ser His His His His His His 
        435                 440                 


<210>  132
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  132

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Ala Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  133
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  133

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Ala Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  134
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  134

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Ala Met Arg Tyr Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  135
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  135

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Ala Arg Tyr Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  136
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  136

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Ala Tyr Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  137
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  137

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Ala Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  138
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  138

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Ala His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  139
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  139

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu Ala Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  140
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  140

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ala 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  141
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  141

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  142
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  142

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Ala Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  143
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  143

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Ala Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  144
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Val Leu Ala Gln Gly Leu Leu Ser Met Ala Leu Leu Ala Leu Cys 
1               5                   10                  15      


Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
            20                  25                  30          


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
        35                  40                  45              


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
    50                  55                  60                  


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
65                  70                  75                  80  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
                85                  90                  95      


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
            100                 105                 110         


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
        115                 120                 125             


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
    130                 135                 140                 


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
145                 150                 155                 160 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
                165                 170                 175     


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
            180                 185                 190         


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
        195                 200                 205             


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
    210                 215                 220                 


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
225                 230                 235                 240 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
                245                 250                 255     


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
            260                 265                 270         


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
        275                 280                 285             


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
    290                 295                 300                 


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
305                 310                 315                 320 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
                325                 330                 335     


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
            340                 345                 350         


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
        355                 360                 365             


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
    370                 375                 380                 


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
385                 390                 395                 400 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
                405                 410                 415     


Ser Arg Thr Ala Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
            420                 425                 430         


Ser Trp Asp Thr Glu Ser His His His His His His 
        435                 440                 


<210>  145
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  145

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Ala Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  146
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  146

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Ala Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  147
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  147

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Asn Ala Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  148
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  148

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Asn Gly Ala Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  149
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide acid sequence encoding trimer oligonucleotide 9A2 L1.1


<220>
<221>  n
<222>  (18)..(23)
<223>  n is any nucleotide provided that a codon comprising the n 
       encoding an amino acid other than cysteine

<220>
<221>  misc_feature
<222>  (18)..(23)
<223>  n is a, c, g, or t

<400>  149
gtcgtgcaag ccagggtnnn nnntggtatc agcagaaacc g                           41


<210>  150
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide acid sequence encoding trimer oligonucleotide 9A2 L3.1


<220>
<221>  n
<222>  (22)..(27)
<223>  "N" is any nucleotide provided that a codon comprising the n 
       encoding an amino acid other than cysteine

<220>
<221>  misc_feature
<222>  (22)..(27)
<223>  n is a, c, g, or t

<220>
<221>  n
<222>  (32)..(37)
<223>  "N" is any nucleotide provided that a codon comprising the n 
       encoding an amino acid other than cysteine

<400>  150
gattttgcaa cctattattg cnnnnnnccg attacctttg gtcag                       45


<210>  151
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide acid sequence encoding trimer oligonucleotide 9A2 L3.2


<220>
<221>  n
<222>  (20)..(25)
<223>  "N" is any nucleotide provided that a codon comprising the n 
       encoding an amino acid other than cysteine

<220>
<221>  misc_feature
<222>  (20)..(25)
<223>  n is a, c, g, or t

<220>
<221>  n
<222>  (21)..(26)
<223>  "N" is any nucleotide provided that a codon comprising the n 
       encoding an amino acid other than cysteine

<400>  151
ctattattgc cagcaggcan nnnnntttgg tcagggcacc cg                          42


<210>  152
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide acid sequence encoding trimer oligonucleotide 9A2 H1.1


<220>
<221>  n
<222>  (20)..(25)
<223>  "N" is any nucleotide provided that a codon comprising the n 
       encoding an amino acid other than cysteine

<220>
<221>  misc_feature
<222>  (20)..(25)
<223>  n is a, c, g, or t

<400>  152
agcaagcggt tttacctttn nnnnntgggt tcgtcaggca cc                          42


<210>  153
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide acid sequence encoding trimer oligonucleotide 9A2 H2.1


<220>
<221>  n
<222>  (20)..(25)
<223>  "N" is any nucleotide provided that a codon comprising the n 
       encoding an amino acid other than cysteine

<220>
<221>  misc_feature
<222>  (20)..(25)
<223>  n is a, c, g, or t

<400>  153
ggaatgggtt agcagcattn nnnnnaccta ttatgccgat agcg                        44


<210>  154
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide acid sequence encoding trimer oligonucleotide 9A2 H3.1


<220>
<221>  n
<222>  (20)..(25)
<223>  "N" is any nucleotide provided that a codon comprising the n 
       encoding an amino acid other than cysteine

<220>
<221>  misc_feature
<222>  (20)..(25)
<223>  n is a, c, g, or t

<400>  154
agtttattat tgcgcacgcn nnnnngatat ttggggtcag ggt                         43


<210>  155
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide acid sequence encoding trimer oligonucleotide 9A2 H3.2


<220>
<221>  n
<222>  (21)..(26)
<223>  "N" is any nucleotide provided that a codon comprising the n 
       encoding an amino acid other than cysteine

<220>
<221>  misc_feature
<222>  (21)..(26)
<223>  n is a, c, g, or t

<400>  155
attattgcgc acgcttttat nnnnnntggg gtcagggtac aatg                        44


<210>  156
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide acid sequence encoding trimer oligonucleotide 
       9A2-VR24-H2.1


<220>
<221>  n
<222>  (20)..(25)
<223>  "N" is any nucleotide provided that a codon comprising the n 
       encoding an amino acid other than cysteine

<220>
<221>  misc_feature
<222>  (20)..(25)
<223>  n is a, c, g, or t

<400>  156
ggaatgggtt agcagcattn nnnnnaccta ttatgccgat agcg                        44


<210>  157
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide acid sequence encoding trimer oligonucleotide 
       9A2-VR24-H2.2


<220>
<221>  n
<222>  (19)..(24)
<223>  "N" is any nucleotide provided that a codon comprising the n 
       encoding an amino acid other than cysteine

<220>
<221>  misc_feature
<222>  (19)..(24)
<223>  n is a, c, g, or t

<400>  157
cgtagcagcg gtggttttnn nnnngtgaaa ggtcgtttta ccat                        44


<210>  158
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide acid sequence encoding trimer oligonucleotide 
       9A2-VR24-H2.3


<220>
<221>  n
<222>  (21)..(26)
<223>  "N" is any nucleotide provided that a codon comprising the n 
       encoding an amino acid other than cysteine

<220>
<221>  misc_feature
<222>  (21)..(26)
<223>  n is a, c, g, or t

<400>  158
gcggtggttt tacctattat nnnnnncgtt ttaccattag ccgtg                       45


<210>  159
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide acid sequence encoding trimer oligonucleotide 
       9A2-VR39-H1.1


<220>
<221>  n
<222>  (20)..(25)
<223>  "N" is any nucleotide provided that a codon comprising the n 
       encoding an amino acid other than cysteine

<220>
<221>  misc_feature
<222>  (20)..(25)
<223>  n is a, c, g, or t

<400>  159
agcaagcggt tttacctttn nnnnntgggt tcgtcaggca cc                          42


<210>  160
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide acid sequence encoding trimer oligonucleotide 
       9A2-VR39-H1.2


<220>
<221>  n
<222>  (18)..(23)
<223>  "N" is any nucleotide provided that a codon comprising the n 
       encoding an amino acid other than cysteine

<220>
<221>  misc_feature
<222>  (18)..(23)
<223>  n is a, c, g, or t

<400>  160
tgagctgtgc agcaagcnnn nnntatcata tgctgtgggt tc                          42


<210>  161
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide acid sequence encoding trimer oligonucleotide 
       9A2-VR39-H2.2


<220>
<221>  n
<222>  (19)..(24)
<223>  "N" is any nucleotide provided that a codon comprising the n 
       encoding an amino acid other than cysteine

<220>
<221>  misc_feature
<222>  (19)..(24)
<223>  n is a, c, g, or t

<400>  161
aatggtcgtg gtcgtgttnn nnnngtgaaa ggtcgtttta cca                         43


<210>  162
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide acid sequence encoding trimer oligonucleotide 
       9A2-VR39-H2.3


<220>
<221>  n
<222>  (21)..(26)
<223>  "N" is any nucleotide provided that a codon comprising the n 
       encoding an amino acid other than cysteine

<220>
<221>  misc_feature
<222>  (21)..(26)
<223>  n is a, c, g, or t

<400>  162
gtggtcgtgt tacctattat nnnnnncgtt ttaccattag ccgtg                       45


<210>  163
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VH chain of stop template of 9A2 H1.1


<220>
<221>  misc_feature
<222>  (30)..(35)
<223>  Xaa can be any naturally occurring amino acid

<400>  163

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  164
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VH chain of stop template of 9A2 H2.1


<220>
<221>  misc_feature
<222>  (52)..(57)
<223>  Xaa can be any naturally occurring amino acid

<400>  164

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Xaa Xaa Xaa Xaa Xaa Xaa Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  165
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VH chain of stop template of 9A2 H3.1


<220>
<221>  misc_feature
<222>  (99)..(104)
<223>  Xaa can be any naturally occurring amino acid

<400>  165

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  166
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VH chain of stop template of 9A2 H3.2


<220>
<221>  misc_feature
<222>  (101)..(106)
<223>  Xaa can be any naturally occurring amino acid

<400>  166

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  167
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VL chain of stop template of 9A2 L1.1


<220>
<221>  misc_feature
<222>  (29)..(34)
<223>  Xaa can be any naturally occurring amino acid

<400>  167

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


<210>  168
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VL chain of stop template of 9A2 L3.1


<220>
<221>  misc_feature
<222>  (89)..(94)
<223>  Xaa can be any naturally occurring amino acid

<400>  168

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Xaa Xaa Xaa Xaa Xaa Xaa Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


<210>  169
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VL chain of stop template of 9A2 L3.2


<220>
<221>  misc_feature
<222>  (92)..(97)
<223>  Xaa can be any naturally occurring amino acid

<400>  169

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


<210>  170
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VH chain of stop template of 9A2 VR24-H2.1


<220>
<221>  misc_feature
<222>  (52)..(57)
<223>  Xaa can be any naturally occurring amino acid

<400>  170

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Xaa Xaa Xaa Xaa Xaa Xaa Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  171
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VH chain of stop template of 9A2 VR24-H2.2


<220>
<221>  misc_feature
<222>  (58)..(63)
<223>  Xaa can be any naturally occurring amino acid

<400>  171

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Xaa Xaa Xaa Xaa Xaa Xaa Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  172
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VH chain of stop template of 9A2 VR24-H2.3


<220>
<221>  misc_feature
<222>  (61)..(66)
<223>  Xaa can be any naturally occurring amino acid

<400>  172

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Thr Tyr Tyr Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  173
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VH chain of stop template of 9A2 VR39-H1.1


<220>
<221>  misc_feature
<222>  (30)..(35)
<223>  Xaa can be any naturally occurring amino acid

<400>  173

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  174
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VH chain of stop template of 9A2 VR39-H1.2


<220>
<221>  misc_feature
<222>  (26)..(31)
<223>  Xaa can be any naturally occurring amino acid

<400>  174

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Xaa Xaa Xaa Xaa Xaa Xaa Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  175
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VH chain of stop template of 9A2 VR39-H2.2


<220>
<221>  misc_feature
<222>  (58)..(63)
<223>  Xaa can be any naturally occurring amino acid

<400>  175

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Xaa Xaa Xaa Xaa Xaa Xaa Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  176
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VH chain of stop template of 9A2 VR39-H2.3


<220>
<221>  misc_feature
<222>  (61)..(66)
<223>  Xaa can be any naturally occurring amino acid

<400>  176

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


His Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Tyr Tyr Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  177
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of consensus of VL chain of 9A2 and 
       derivatives


<220>
<221>  X
<222>  (29)..(29)
<223>  I, Q, L or V

<220>
<221>  X
<222>  (30)..(30)
<223>  S or R

<220>
<221>  X
<222>  (31)..(31)
<223>  S or P

<220>
<221>  X
<222>  (32)..(32)
<223>  W or F

<220>
<221>  X
<222>  (33)..(33)
<223>  L, M, V or I

<220>
<221>  X
<222>  (34)..(34)
<223>  A, S, N or D

<220>
<221>  X
<222>  (89)..(89)
<223>  Q or G

<220>
<221>  X
<222>  (90)..(90)
<223>  Q, K or I

<220>
<221>  X
<222>  (91)..(91)
<223>  A or P

<220>
<221>  X
<222>  (92)..(92)
<223>  N, V or I

<220>
<221>  X
<222>  (93)..(93)
<223>  S, L or F

<220>
<221>  X
<222>  (94)..(94)
<223>  F, D or G

<400>  177

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Xaa Xaa Xaa Xaa Xaa Xaa Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


<210>  178
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of consensus of CDR1 of VL chain of 9A2 and 
       derivatives


<220>
<221>  X
<222>  (6)..(6)
<223>  I, Q, L or V

<220>
<221>  X
<222>  (7)..(7)
<223>  S or R

<220>
<221>  X
<222>  (8)..(8)
<223>  S or P

<220>
<221>  X
<222>  (9)..(9)
<223>  W or F

<220>
<221>  X
<222>  (10)..(10)
<223>  L, M, V or I

<220>
<221>  X
<222>  (11)..(11)
<223>  A, S, N or D

<400>  178

Arg Ala Ser Gln Gly Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  179
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of consensus of CDR3 of VL chain of 9A2 and 
       derivatives


<220>
<221>  X
<222>  (1)..(1)
<223>  Q or G

<220>
<221>  X
<222>  (2)..(2)
<223>  Q,K or I

<220>
<221>  X
<222>  (3)..(3)
<223>  A or P

<220>
<221>  X
<222>  (4)..(4)
<223>  N,V or I

<220>
<221>  X
<222>  (5)..(5)
<223>  S,L or F

<220>
<221>  X
<222>  (6)..(6)
<223>  F, D or G

<400>  179

Xaa Xaa Xaa Xaa Xaa Xaa Pro Ile Thr 
1               5                   


<210>  180
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of consensus of VH chain of 9A2 and 
       derivatives


<220>
<221>  X
<222>  (30)..(30)
<223>  S,N,M,Q,E,P,I,T or V

<220>
<221>  X
<222>  (31)..(31)
<223>  H or W

<220>
<221>  X
<222>  (33)..(33)
<223>  H or R

<220>
<221>  X
<222>  (34)..(34)
<223>  M or V

<220>
<221>  X
<222>  (35)..(35)
<223>  L or H

<220>
<221>  X
<222>  (52)..(52)
<223>  R,S,N or G

<220>
<221>  X
<222>  (53)..(53)
<223>  S or G

<220>
<221>  X
<222>  (54)..(54)
<223>  S,A,F,D,M,R,Y or K

<220>
<221>  X
<222>  (55)..(55)
<223>  G,Q,V,H,K,M or I

<220>
<221>  X
<222>  (56)..(56)
<223>  G,W,R,F,W,A or I

<220>
<221>  X
<222>  (57)..(57)
<223>  F,S,T,P,N,Q or V

<220>
<221>  X
<222>  (101)..(101)
<223>  D or S

<220>
<221>  X
<222>  (102)..(102)
<223>  S or D

<220>
<221>  X
<222>  (103)..(103)
<223>  F,H or N

<220>
<221>  X
<222>  (105)..(105)
<223>  D,R,S,K,N or A

<220>
<221>  X
<222>  (106)..(106)
<223>  I,E or P

<400>  180

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Xaa Xaa Tyr 
            20                  25                  30          


Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Xaa Xaa Xaa Xaa Xaa Xaa Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Xaa Xaa Xaa Phe Xaa Xaa Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  181
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of consensus of CDR1 of VH chain of 9A2 and 
       derivatives


<220>
<221>  X
<222>  (5)..(5)
<223>  S,N,M,Q,E,P,I,T or V

<220>
<221>  X
<222>  (6)..(6)
<223>  H or W

<220>
<221>  X
<222>  (8)..(8)
<223>  H or R

<220>
<221>  X
<222>  (9)..(9)
<223>  M or V

<220>
<221>  X
<222>  (10)..(10)
<223>  L or H

<400>  181

Gly Phe Thr Phe Xaa Xaa Tyr Xaa Xaa Xaa 
1               5                   10  


<210>  182
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of consensus of CDR2 of VH chain of 9A2 and 
       derivatives


<220>
<221>  X
<222>  (3)..(3)
<223>  R,S,N or G

<220>
<221>  X
<222>  (4)..(4)
<223>  S or G

<220>
<221>  X
<222>  (5)..(5)
<223>  S,A,F,D,M,R,Y or K

<220>
<221>  X
<222>  (6)..(6)
<223>  G,Q,V,H,K,M or I

<220>
<221>  X
<222>  (7)..(7)
<223>  G,W,R,F,W,A or I

<220>
<221>  X
<222>  (8)..(8)
<223>  F,S,T,P,N,Q or V

<400>  182

Ser Ile Xaa Xaa Xaa Xaa Xaa Xaa Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  183
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of consensus of CDR3 of VH chain of 9A2 and 
       derivatives


<220>
<221>  X
<222>  (3)..(3)
<223>  D or S

<220>
<221>  X
<222>  (4)..(4)
<223>  S or D

<220>
<221>  X
<222>  (5)..(5)
<223>  F,H or N

<220>
<221>  X
<222>  (7)..(7)
<223>  D,R,S,K,N or A

<220>
<221>  X
<222>  (8)..(8)
<223>  I, E or P

<400>  183

Phe Tyr Xaa Xaa Xaa Phe Xaa Xaa 
1               5               


<210>  184
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of consensus of VH chain of 9A2-VR24 and 
       derivatives


<220>
<221>  X
<222>  (52)..(52)
<223>  R,H,Q or K

<220>
<221>  X
<222>  (53)..(53)
<223>  S,T,H or N

<220>
<221>  X
<222>  (54)..(54)
<223>  S,H,G,Q,D or E

<220>
<221>  X
<222>  (55)..(55)
<223>  G,R,S,Y or N

<220>
<221>  X
<222>  (56)..(56)
<223>  G,H,N,Q,K,T,V,R,P or D

<220>
<221>  X
<222>  (57)..(57)
<223>  F,I,S,W,V or Y

<220>
<221>  X
<222>  (58)..(58)
<223>  T or P

<220>
<221>  X
<222>  (59)..(59)
<223>  Y,H,F or M

<220>
<221>  X
<222>  (61)..(61)
<223>  A,H,N,S or T

<220>
<221>  X
<222>  (62)..(62)
<223>  D,Q,Y,R,H,P,L,S or N

<220>
<221>  X
<222>  (63)..(63)
<223>  S,K,R,V,F,H,A or E

<220>
<221>  X
<222>  (65)..(65)
<223>  K,R or M

<220>
<221>  X
<222>  (66)..(66)
<223>  G,N or H

<400>  184

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa Xaa Val 
    50                  55                  60                  


Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  185
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of consensus of CDR1 of VH chain of 9A2-VR24 
       and derivatives

<400>  185

Gly Phe Thr Phe Pro Trp Tyr Arg Val His 
1               5                   10  


<210>  186
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of consensus of CDR2 of VH chain of 9A2-VR24 
       and derivatives


<220>
<221>  X
<222>  (3)..(3)
<223>  R, H, Q or K

<220>
<221>  X
<222>  (4)..(4)
<223>  S, T, H or N

<220>
<221>  X
<222>  (5)..(5)
<223>  S, H, G, Q, D or E

<220>
<221>  X
<222>  (6)..(6)
<223>  G, R, S, Y or N

<220>
<221>  X
<222>  (7)..(7)
<223>  G, H, N, Q, K, T, V, R, P or D

<220>
<221>  X
<222>  (8)..(8)
<223>  F, I, S, W, V or Y

<220>
<221>  X
<222>  (9)..(9)
<223>  T or P

<220>
<221>  X
<222>  (10)..(10)
<223>  Y, H , F or M

<220>
<221>  X
<222>  (12)..(12)
<223>  A, H, N, S or T

<220>
<221>  X
<222>  (13)..(13)
<223>  D, Q, Y, R, H, P, L, S or N

<220>
<221>  X
<222>  (14)..(14)
<223>  S, K, R, V, F, H, A or E

<220>
<221>  X
<222>  (16)..(16)
<223>  K, R or M

<220>
<221>  X
<222>  (17)..(17)
<223>  G, N or H

<400>  186

Ser Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa Xaa Val Xaa 
1               5                   10                  15      


Xaa 
    


<210>  187
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of consensus of CDR3 of VH chain of 9A2-VR24 
       and derivatives

<400>  187

Phe Tyr Asp Ser Phe Phe Asp Ile 
1               5               


<210>  188
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of consensus of VH chain of 9A2-VR39 and 
       derivatives


<220>
<221>  X
<222>  (26)..(26)
<223>  G, R, D, A or P

<220>
<221>  X
<222>  (27)..(27)
<223>  F, G, V, R or Y

<220>
<221>  X
<222>  (28)..(28)
<223>  T, S, A, P, F or W

<220>
<221>  X
<222>  (29)..(29)
<223>  F, P or E

<220>
<221>  X
<222>  (30)..(30)
<223>  S, F, Y, N, P, Q, H, E, M, V, G, W or M

<220>
<221>  X
<222>  (31)..(31)
<223>  H, W, E, F, G, Y or N

<220>
<221>  X
<222>  (32)..(32)
<223>  Y or F

<220>
<221>  X
<222>  (33)..(33)
<223>  H, M, Q, N or V

<220>
<221>  X
<222>  (34)..(34)
<223>  M, H, T, Y, I, K, W, V, F or Q

<220>
<221>  X
<222>  (35)..(35)
<223>  L, V or I

<220>
<221>  X
<222>  (59)..(59)
<223>  Y, H or Q

<220>
<221>  X
<222>  (60)..(60)
<223>  Y, V or M

<220>
<221>  X
<222>  (61)..(61)
<223>  A, Q or N

<220>
<221>  X
<222>  (62)..(62)
<223>  D, Q, W, P, R or L

<220>
<221>  X
<222>  (63)..(63)
<223>  S, E, P, A or D

<220>
<221>  X
<222>  (64)..(64)
<223>  V, M, W, H or Y

<220>
<221>  X
<222>  (65)..(65)
<223>  K or N

<220>
<221>  X
<222>  (66)..(66)
<223>  G or K

<400>  188

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Gly Arg Gly Arg Val Thr Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  189
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of consensus of CDR1 of VH chain of 9A2-VR39 
       and derivatives


<220>
<221>  X
<222>  (1)..(1)
<223>  G, R, D, A or P

<220>
<221>  X
<222>  (2)..(2)
<223>  F, G, V, R or Y

<220>
<221>  X
<222>  (3)..(3)
<223>  T, S, A, P, F or W

<220>
<221>  X
<222>  (4)..(4)
<223>  F, P or E

<220>
<221>  X
<222>  (5)..(5)
<223>  S, F, Y, N, P, Q, H, E, M, V, G, W or M

<220>
<221>  X
<222>  (6)..(6)
<223>  H, W, E, F, G, Y or N

<220>
<221>  X
<222>  (7)..(7)
<223>  Y or F

<220>
<221>  X
<222>  (8)..(8)
<223>  H, M, Q, N or V

<220>
<221>  X
<222>  (9)..(9)
<223>  M, H, T, Y, I, K, W, V, F or Q

<220>
<221>  X
<222>  (10)..(10)
<223>  L, V or I

<400>  189

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10  


<210>  190
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of consensus of CDR2 of VH chain of 9A2-VR39 
       and derivatives


<220>
<221>  X
<222>  (10)..(10)
<223>  Y, H or Q

<220>
<221>  X
<222>  (11)..(11)
<223>  Y, V or M

<220>
<221>  X
<222>  (12)..(12)
<223>  A, Q or N

<220>
<221>  X
<222>  (13)..(13)
<223>  D, Q, W, P, R or L

<220>
<221>  X
<222>  (14)..(14)
<223>  S, E, P, A or D

<220>
<221>  X
<222>  (15)..(15)
<223>  V, M, W, H or Y

<220>
<221>  X
<222>  (16)..(16)
<223>  K or N

<220>
<221>  X
<222>  (17)..(17)
<223>  G or K

<400>  190

Ser Ile Asn Gly Arg Gly Arg Val Thr Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa 
    


<210>  191
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of consensus of CDR3 of VH chain of 9A2-VR39 
       and derivatives

<400>  191

Phe Tyr Asp Ser Phe Phe Asp Ile 
1               5               


<210>  192
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  192

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser His His His His His His 
            420                 425             


<210>  193
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of VH chain of 9A2-VR24 HCDR2 mutants


<220>
<221>  misc_feature
<222>  (52)..(59)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (61)..(63)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (65)..(66)
<223>  Xaa can be any naturally occurring amino acid

<400>  193

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa Xaa Val 
    50                  55                  60                  


Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  194
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of antibody 9A2 heavy chain

<400>  194

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Trp Tyr 
            20                  25                  30          


Arg Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Ser Ser Gly Gly Phe Pro Tyr Tyr Asn Tyr Lys Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Asp Ser Phe Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 


<210>  195
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of antibody 9A2 light chain

<400>  195

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Leu Arg Pro Phe 
            20                  25                  30          


Val Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  196
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of stabilized IgG4 heavy chain constant 
       region

<400>  196

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  197
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of kappa light chain constant region

<400>  197

Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
1               5                   10                  15      


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
            20                  25                  30          


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
        35                  40                  45              


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
65                  70                  75                  80  


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
                85                  90                  95      


Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 


