                         SEQUENCE LISTING

<110>  UNIVERSITE PARIS DESCARTES
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
       INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 
       (INSERM)
       ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
 
<120>  INHIBITORS FOR TREATING OR PREVENTING A PULMONARY ARTERIAL 
       HYPERTENSION IN SYSTEMIC SCLEROSIS PATIENTS AND METHOD FOR 
       DIAGNOSING SAID DISEASE

<130>  B371402D35491

<150>  EP15306882.0
<151>  2015-11-26

<150>  EP16020154.7
<151>  2016-04-26

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  1743
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  cDNA encoding human pro-MMP10

<400>  1
aaagaaggta agggcagtga gaatgatgca tcttgcattc cttgtgctgt tgtgtctgcc       60

agtctgctct gcctatcctc tgagtggggc agcaaaagag gaggactcca acaaggatct      120

tgcccagcaa tacctagaaa agtactacaa cctcgaaaag gatgtgaaac agtttagaag      180

aaaggacagt aatctcattg ttaaaaaaat ccaaggaatg cagaagttcc ttgggttgga      240

ggtgacaggg aagctagaca ctgacactct ggaggtgatg cgcaagccca ggtgtggagt      300

tcctgacgtt ggtcacttca gctcctttcc tggcatgccg aagtggagga aaacccacct      360

tacatacagg attgtgaatt atacaccaga tttgccaaga gatgctgttg attctgccat      420

tgagaaagct ctgaaagtct gggaagaggt gactccactc acattctcca ggctgtatga      480

aggagaggct gatataatga tctctttcgc agttaaagaa catggagact tttactcttt      540

tgatggccca ggacacagtt tggctcatgc ctacccacct ggacctgggc tttatggaga      600

tattcacttt gatgatgatg aaaaatggac agaagatgca tcaggcacca atttattcct      660

cgttgctgct catgaacttg gccactccct ggggctcttt cactcagcca acactgaagc      720

tttgatgtac ccactctaca actcattcac agagctcgcc cagttccgcc tttcgcaaga      780

tgatgtgaat ggcattcagt ctctctacgg acctccccct gcctctactg aggaacccct      840

ggtgcccaca aaatctgttc cttcgggatc tgagatgcca gccaagtgtg atcctgcttt      900

gtccttcgat gccatcagca ctctgagggg agaatatctg ttctttaaag acagatattt      960

ttggcgaaga tcccactgga accctgaacc tgaatttcat ttgatttctg cattttggcc     1020

ctctcttcca tcatatttgg atgctgcata tgaagttaac agcagggaca ccgtttttat     1080

ttttaaagga aatgagttct gggccatcag aggaaatgag gtacaagcag gttatccaag     1140

aggcatccat accctgggtt ttcctccaac cataaggaaa attgatgcag ctgtttctga     1200

caaggaaaag aagaaaacat acttctttgc agcggacaaa tactggagat ttgatgaaaa     1260

tagccagtcc atggagcaag gcttccctag actaatagct gatgactttc caggagttga     1320

gcctaaggtt gatgctgtat tacaggcatt tggatttttc tacttcttca gtggatcatc     1380

acagtttgag tttgacccca atgccaggat ggtgacacac atattaaaga gtaacagctg     1440

gttacattgc taggcgagat agggggaaga cagatatggg tgtttttaat aaatctaata     1500

attattcatc taatgtatta tgagccaaaa tggttaattt ttcctgcatg ttctgtgact     1560

gaagaagatg agccttgcag atatctgcat gtgtcatgaa gaatgtttct ggaattcttc     1620

acttgctttt gaattgcact gaacagaatt aagaaatact catgtgcaat aggtgagaga     1680

atgtattttc atagatgtgt tattacttcc tcaataaaaa gttttatttt gggcctgttc     1740

ctt                                                                   1743


<210>  2
<211>  476
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  pro-MMP10

<400>  2

Met Met His Leu Ala Phe Leu Val Leu Leu Cys Leu Pro Val Cys Ser 
1               5                   10                  15      


Ala Tyr Pro Leu Ser Gly Ala Ala Lys Glu Glu Asp Ser Asn Lys Asp 
            20                  25                  30          


Leu Ala Gln Gln Tyr Leu Glu Lys Tyr Tyr Asn Leu Glu Lys Asp Val 
        35                  40                  45              


Lys Gln Phe Arg Arg Lys Asp Ser Asn Leu Ile Val Lys Lys Ile Gln 
    50                  55                  60                  


Gly Met Gln Lys Phe Leu Gly Leu Glu Val Thr Gly Lys Leu Asp Thr 
65                  70                  75                  80  


Asp Thr Leu Glu Val Met Arg Lys Pro Arg Cys Gly Val Pro Asp Val 
                85                  90                  95      


Gly His Phe Ser Ser Phe Pro Gly Met Pro Lys Trp Arg Lys Thr His 
            100                 105                 110         


Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp Leu Pro Arg Asp Ala 
        115                 120                 125             


Val Asp Ser Ala Ile Glu Lys Ala Leu Lys Val Trp Glu Glu Val Thr 
    130                 135                 140                 


Pro Leu Thr Phe Ser Arg Leu Tyr Glu Gly Glu Ala Asp Ile Met Ile 
145                 150                 155                 160 


Ser Phe Ala Val Lys Glu His Gly Asp Phe Tyr Ser Phe Asp Gly Pro 
                165                 170                 175     


Gly His Ser Leu Ala His Ala Tyr Pro Pro Gly Pro Gly Leu Tyr Gly 
            180                 185                 190         


Asp Ile His Phe Asp Asp Asp Glu Lys Trp Thr Glu Asp Ala Ser Gly 
        195                 200                 205             


Thr Asn Leu Phe Leu Val Ala Ala His Glu Leu Gly His Ser Leu Gly 
    210                 215                 220                 


Leu Phe His Ser Ala Asn Thr Glu Ala Leu Met Tyr Pro Leu Tyr Asn 
225                 230                 235                 240 


Ser Phe Thr Glu Leu Ala Gln Phe Arg Leu Ser Gln Asp Asp Val Asn 
                245                 250                 255     


Gly Ile Gln Ser Leu Tyr Gly Pro Pro Pro Ala Ser Thr Glu Glu Pro 
            260                 265                 270         


Leu Val Pro Thr Lys Ser Val Pro Ser Gly Ser Glu Met Pro Ala Lys 
        275                 280                 285             


Cys Asp Pro Ala Leu Ser Phe Asp Ala Ile Ser Thr Leu Arg Gly Glu 
    290                 295                 300                 


Tyr Leu Phe Phe Lys Asp Arg Tyr Phe Trp Arg Arg Ser His Trp Asn 
305                 310                 315                 320 


Pro Glu Pro Glu Phe His Leu Ile Ser Ala Phe Trp Pro Ser Leu Pro 
                325                 330                 335     


Ser Tyr Leu Asp Ala Ala Tyr Glu Val Asn Ser Arg Asp Thr Val Phe 
            340                 345                 350         


Ile Phe Lys Gly Asn Glu Phe Trp Ala Ile Arg Gly Asn Glu Val Gln 
        355                 360                 365             


Ala Gly Tyr Pro Arg Gly Ile His Thr Leu Gly Phe Pro Pro Thr Ile 
    370                 375                 380                 


Arg Lys Ile Asp Ala Ala Val Ser Asp Lys Glu Lys Lys Lys Thr Tyr 
385                 390                 395                 400 


Phe Phe Ala Ala Asp Lys Tyr Trp Arg Phe Asp Glu Asn Ser Gln Ser 
                405                 410                 415     


Met Glu Gln Gly Phe Pro Arg Leu Ile Ala Asp Asp Phe Pro Gly Val 
            420                 425                 430         


Glu Pro Lys Val Asp Ala Val Leu Gln Ala Phe Gly Phe Phe Tyr Phe 
        435                 440                 445             


Phe Ser Gly Ser Ser Gln Phe Glu Phe Asp Pro Asn Ala Arg Met Val 
    450                 455                 460                 


Thr His Ile Leu Lys Ser Asn Ser Trp Leu His Cys 
465                 470                 475     


<210>  3
<211>  378
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  MMP10

<400>  3

Phe Ser Ser Phe Pro Gly Met Pro Lys Trp Arg Lys Thr His Leu Thr 
1               5                   10                  15      


Tyr Arg Ile Val Asn Tyr Thr Pro Asp Leu Pro Arg Asp Ala Val Asp 
            20                  25                  30          


Ser Ala Ile Glu Lys Ala Leu Lys Val Trp Glu Glu Val Thr Pro Leu 
        35                  40                  45              


Thr Phe Ser Arg Leu Tyr Glu Gly Glu Ala Asp Ile Met Ile Ser Phe 
    50                  55                  60                  


Ala Val Lys Glu His Gly Asp Phe Tyr Ser Phe Asp Gly Pro Gly His 
65                  70                  75                  80  


Ser Leu Ala His Ala Tyr Pro Pro Gly Pro Gly Leu Tyr Gly Asp Ile 
                85                  90                  95      


His Phe Asp Asp Asp Glu Lys Trp Thr Glu Asp Ala Ser Gly Thr Asn 
            100                 105                 110         


Leu Phe Leu Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Phe 
        115                 120                 125             


His Ser Ala Asn Thr Glu Ala Leu Met Tyr Pro Leu Tyr Asn Ser Phe 
    130                 135                 140                 


Thr Glu Leu Ala Gln Phe Arg Leu Ser Gln Asp Asp Val Asn Gly Ile 
145                 150                 155                 160 


Gln Ser Leu Tyr Gly Pro Pro Pro Ala Ser Thr Glu Glu Pro Leu Val 
                165                 170                 175     


Pro Thr Lys Ser Val Pro Ser Gly Ser Glu Met Pro Ala Lys Cys Asp 
            180                 185                 190         


Pro Ala Leu Ser Phe Asp Ala Ile Ser Thr Leu Arg Gly Glu Tyr Leu 
        195                 200                 205             


Phe Phe Lys Asp Arg Tyr Phe Trp Arg Arg Ser His Trp Asn Pro Glu 
    210                 215                 220                 


Pro Glu Phe His Leu Ile Ser Ala Phe Trp Pro Ser Leu Pro Ser Tyr 
225                 230                 235                 240 


Leu Asp Ala Ala Tyr Glu Val Asn Ser Arg Asp Thr Val Phe Ile Phe 
                245                 250                 255     


Lys Gly Asn Glu Phe Trp Ala Ile Arg Gly Asn Glu Val Gln Ala Gly 
            260                 265                 270         


Tyr Pro Arg Gly Ile His Thr Leu Gly Phe Pro Pro Thr Ile Arg Lys 
        275                 280                 285             


Ile Asp Ala Ala Val Ser Asp Lys Glu Lys Lys Lys Thr Tyr Phe Phe 
    290                 295                 300                 


Ala Ala Asp Lys Tyr Trp Arg Phe Asp Glu Asn Ser Gln Ser Met Glu 
305                 310                 315                 320 


Gln Gly Phe Pro Arg Leu Ile Ala Asp Asp Phe Pro Gly Val Glu Pro 
                325                 330                 335     


Lys Val Asp Ala Val Leu Gln Ala Phe Gly Phe Phe Tyr Phe Phe Ser 
            340                 345                 350         


Gly Ser Ser Gln Phe Glu Phe Asp Pro Asn Ala Arg Met Val Thr His 
        355                 360                 365             


Ile Leu Lys Ser Asn Ser Trp Leu His Cys 
    370                 375             


