                         SEQUENCE LISTING

<110>  North Carolina State University
       Dewey, Ralph E.
       Lewis, Ramsey S.
 
<120>  TARGETED MUTAGENESIS OF TOBACCO BERBERINE BRIDGE ENZYME-LIKE 
       NUCLEIC ACIDS

<130>  5051-894WO

<150>  US 62/263,151
<151>  2015-12-04

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  1704
<212>  DNA
<213>  Nicotiana tabacum

<400>  1
atgaaacgaa atatatccat gtttcttcag cttctgctca ttattctgat gatgatcagc       60

ttcttattta cttctcttct tgtaccttcg gtctctgcaa caactctcaa taccatttcc      120

acctgtttaa tcaattacaa agtcagtaac ttctctgttt acccaacaag gaatcatgct      180

ggtaatagtt actataactt gcttgatttc tccattcaga atctccgatt cgcagcgtgc      240

tctaaaccaa aaccaactgt cattatcgta ccagagagca aggagcagct ggtgagcagc      300

gttctgtgtt gcagacaagg ctcgtatgaa atcagagtaa ggtgcggtgg acacagttat      360

gaagggactt catcagtttc ctttgatggt tccccatttg tggtcattga tttgatgaaa      420

ttagacggcg tttcagtgga tgtggattca gaaaccgcgt gggtacaggg cggcgctaca      480

cttggccaga cttattatgc catttcccga gccagcaacg ttcatggatt ttcagctggt      540

tcttgcccaa cagttggggt tggcgggcac atttccgggg gtggttacgg atttttatcc      600

agaaaatatg gacttgctgc tgataacgtg gtggatgctc ttcttgttga tgcggaagga      660

cggctattag accgcaaagc catgggagaa gaaatctttt gggccatcag aggtggaggt      720

ggaggaattt ggggaatcat ttacgcctgg aaaatccgat tgctcaaagt gcccaagacc      780

gtgaccagtt tcataatccc taggcctggc tccaaacgat atgtgtccca actagttcac      840

aaatggcaac ttgttgcacc aaagttagag gatgaatttt atctatcgat ctccatgagc      900

tctcctagta aaggaaacat tcctattgaa ataaatgccc aattcagcgg attttaccta      960

ggtacaaaaa ccgaagccat ttccatcttg aatgaggcct tttcggagtt gggagttctg     1020

gaaggtgact gcaaagaaat gagttggatt gaatcaacac ttttcttctc cgaattaaat     1080

gacgttgcga attcctccga tgtctctcgt ttgaaagagc gttactttga aaacaaatca     1140

tacttcaaag ccaaatcaga ctatgtgaag accccaattt cagtgggtgg gattatgacg     1200

gctcttaatg ttcttgagaa agaacccaac ggacatgtca tcttggaccc ttatggtgga     1260

gccatgcaaa gaattagtga ggaagctatt gctttccctc atagaaaggg taaccttttc     1320

ggaattcaat atctagtagt gtggaaagaa aaggacaata ataatattgt caagagcaat     1380

attgggtaca tagagtggat aagagagttt tacaatacaa tggcacccca tgtttcaagt     1440

tcacctaggg cagcttatgt caactacatg gatctggacc ttggagtgat ggacgactac     1500

ttattgccat gtactagtac tactgcgtct gctaatcatg ccgtggagag agcaagggtc     1560

tggggtgaaa agtatttctt gaataactat gatagattgg tcaaagctaa gacaaaaatt     1620

gacccactaa acgtttttcg acatcaacag ggcatccctc ctttgttcgc ctcaatgcaa     1680

gagtatacct atagtagtaa atga                                            1704


<210>  2
<211>  1701
<212>  DNA
<213>  Nicotiana tabacum

<400>  2
atgaaacgaa atatatccat gtctcttcag cgtttgctca taattctgat gatgatcagc       60

ttcttattta cttctcttct tgtaccttcc gtctctgcta caaatctcaa taccatttcc      120

acctgtttga tcaattacaa agtcagtaac ttctctgttt atccaacaag gaatcatgct      180

ggtaataggt actataactt gcttgatttc tccattcaga atctccgatt cgcagcgtcc      240

tctaaaccaa aaccaacggt cattatcgta ccagagagca aggagcagct ggtgagcagc      300

gttctgtgtt gcagacaagg ttcttatgaa atcagagtaa ggtgcggagg acacagttat      360

gaagggactt cttacgtttc ctttgatggt tccccatttg tggtcattga tttgatgaaa      420

ttagatgatg tttcggtaga tttggattcc gaaaccgcgt gggtacaagg tggcgctaca      480

cttggccaga cttattatgc catttcccgg gccagtgacg ttcatggatt ttcagctggt      540

tcttgcccaa cagttggggt tgggggccac atttccgggg gtggctttgg atttttatca      600

agaaaatatg gacttgctgc tgataacgtg gtggatgctc ttcttgttga tgcggaagga      660

cggctattag accgcaaagc catgggagaa gaagtgtttt gggccatcag aggtggtggt      720

ggaggaattt ggggaatcat ttacgcctgg aaaatccgat tgctcaaagt gcccaagact      780

gtgactagtt tcatagtccc taggcctggc tccaaacgat atgtgtccca actagttcac      840

aaatggcaac ttgttgcacc aaagttagac gatgactttt atctatcgat ctccatgagc      900

tctgctagta aaggaaacat tcctattgaa ataaatgccc aattcagcgg attttaccta      960

ggtacaaaaa ccgaagccat ttccatcttg aatgaggcct ttccggagtt gggagttgtg     1020

gaaagtgact gcaaagaaat gagttggatt gaatcaacac ttttcttctc cgaattagat     1080

aacgttgcga acacctccga tgtctctcgt ttgaaagagc gttactttga aaacaaatca     1140

tacttcaaag ccaaatcaga ccatgtgaag accccaattt cagtgggagg gattatgaca     1200

gctcttgatg ttcttgagaa agaaccaaat ggacatgtca tctttgaccc ttatggtgca     1260

gccatgcaga gaattagcga ggaagctatt gctttccctc atagaaaggg taacctattc     1320

agaattcaat atctagtagt gtggaaagaa aaggacaata ataatattgc caagagcaat     1380

gggtacatag agtggataag agagttttac aatacaatgg caccccatgt ttctagttca     1440

cctagggcag cttatgtcaa ctatatggat ctggaccttg gagtgatgga cgactactta     1500

atgctaaata ctagtattac tgcctctgct gatcatgccg tggagagagc aagggtctgg     1560

ggtgaaaagt atttcttgaa taactatgat agattggtca aagctaagac aaaaattgac     1620

ccactaaacg tttttcgaca tcaacagggc atccctccta tgttcgcctc aatgccagag     1680

catacctata gtagtaaatg a                                               1701


<210>  3
<211>  1698
<212>  DNA
<213>  Nicotiana tabacum

<400>  3
atgtttccaa tcataattct gatcagcttt tcatttactt tcctctttgc tagtgttact       60

agtggagcag gaggagttac aaatctttcc acctgtttaa tcaaccacaa tgtccataac      120

ttctctattt accccacaaa gaatgatcaa agtagtagta attactttaa cttgctcgat      180

ttttcccttc agaatcttcg atttgctgca tcttacatgc cgaaaccaac ggtcattatc      240

ctaccaaaca gcaaagagga gctcgtgagt accattcttt gttgcagaca aacatcttat      300

gaaatcagag taaggtgcgg aggacacagt tacgagggaa cttcttacgt ttcctttgac      360

ggttcccctt tcgtgatcgt tgacttgatg aaattagacg acgtttcagt agatttggat      420

tccgaaacag cttgggctca gggcggcgca acaattggcc aaatttatta cgccatttcc      480

agggttagtg acgttcatgc attttcagca ggttcgggac caacagtagg atctggaggt      540

catatttcag gtggcggctt tggactaatg tccagaaaat tcggactcgc tgctgatagt      600

gtcgttgatg ctcttctaat tgatgctgaa ggacggttat tagaccggaa agccatggga      660

gaagacgtat tttgggcaat cagaggtggc ggcggtggaa attggggaat tatttatgcc      720

tggaaaattc gattactcaa agtgcctaaa atcgtaacaa cttgtatgat ctataggcct      780

ggatccaaac aatacgtggc tcaactactt cagaaatggc aaatagttac tccaaatttg      840

gccgatgatt ttactctagg agtactcatg agacctatag atctgcgggc ggatatgaat      900

tacggaaata ctactcctat tgaaacattt ccccaattca atgcacttta tttgggtcca      960

aaaactgaag cggtttccat attaaatgag gcatttccag agctggacgc taagaatgat     1020

gacgccaaag aaatgacttg gattgagtca gcacttttct tttccgaatt agataacgta     1080

ttcgggaact cctctgacga tatctcccgt ttgaaagaac gctacatgga cgcaaaaact     1140

ttcttcaaag gcaaatcaga ttttgtgaag actccatttt caatggacgc gatgatgaca     1200

gctcttgttg aactcgagaa aaaccccaag tcattccttg tcttcgatcc ttatggcgga     1260

gtcatggaca agattagtga tcaagctatt gctttccctc atcgaaaggg taaccttttc     1320

gcggttcaat attatgcatt ttggaacgaa gaggacgatg ccaagagcaa cgagtacata     1380

gagtggacaa ggggatttta caataaaatg gcgccttttg tttcaagctc gccaagggga     1440

gcttatatca actacttgga tatggatctt ggagtgaata tggacgacga ctacttactg     1500

cgaaatgcta gtagtcgtag ttcttcttcc tctgttgatg ctgtggagag agctagagcg     1560

tggggtgaaa tgtatttctt gcataactat gataggttgg ttaaagctaa gacacaaatt     1620

gatccactaa atgtttttcg acatgaacag agtatacctc ctatgcttgg ttcaacgcaa     1680

gagcacagta gtgaatga                                                   1698


<210>  4
<211>  567
<212>  PRT
<213>  Nicotiana tabacum

<400>  4

Met Lys Arg Asn Ile Ser Met Phe Leu Gln Leu Leu Leu Ile Ile Leu 
1               5                   10                  15      


Met Met Ile Ser Phe Leu Phe Thr Ser Leu Leu Val Pro Ser Val Ser 
            20                  25                  30          


Ala Thr Thr Leu Asn Thr Ile Ser Thr Cys Leu Ile Asn Tyr Lys Val 
        35                  40                  45              


Ser Asn Phe Ser Val Tyr Pro Thr Arg Asn His Ala Gly Asn Ser Tyr 
    50                  55                  60                  


Tyr Asn Leu Leu Asp Phe Ser Ile Gln Asn Leu Arg Phe Ala Ala Cys 
65                  70                  75                  80  


Ser Lys Pro Lys Pro Thr Val Ile Ile Val Pro Glu Ser Lys Glu Gln 
                85                  90                  95      


Leu Val Ser Ser Val Leu Cys Cys Arg Gln Gly Ser Tyr Glu Ile Arg 
            100                 105                 110         


Val Arg Cys Gly Gly His Ser Tyr Glu Gly Thr Ser Ser Val Ser Phe 
        115                 120                 125             


Asp Gly Ser Pro Phe Val Val Ile Asp Leu Met Lys Leu Asp Gly Val 
    130                 135                 140                 


Ser Val Asp Val Asp Ser Glu Thr Ala Trp Val Gln Gly Gly Ala Thr 
145                 150                 155                 160 


Leu Gly Gln Thr Tyr Tyr Ala Ile Ser Arg Ala Ser Asn Val His Gly 
                165                 170                 175     


Phe Ser Ala Gly Ser Cys Pro Thr Val Gly Val Gly Gly His Ile Ser 
            180                 185                 190         


Gly Gly Gly Tyr Gly Phe Leu Ser Arg Lys Tyr Gly Leu Ala Ala Asp 
        195                 200                 205             


Asn Val Val Asp Ala Leu Leu Val Asp Ala Glu Gly Arg Leu Leu Asp 
    210                 215                 220                 


Arg Lys Ala Met Gly Glu Glu Ile Phe Trp Ala Ile Arg Gly Gly Gly 
225                 230                 235                 240 


Gly Gly Ile Trp Gly Ile Ile Tyr Ala Trp Lys Ile Arg Leu Leu Lys 
                245                 250                 255     


Val Pro Lys Thr Val Thr Ser Phe Ile Ile Pro Arg Pro Gly Ser Lys 
            260                 265                 270         


Arg Tyr Val Ser Gln Leu Val His Lys Trp Gln Leu Val Ala Pro Lys 
        275                 280                 285             


Leu Glu Asp Glu Phe Tyr Leu Ser Ile Ser Met Ser Ser Pro Ser Lys 
    290                 295                 300                 


Gly Asn Ile Pro Ile Glu Ile Asn Ala Gln Phe Ser Gly Phe Tyr Leu 
305                 310                 315                 320 


Gly Thr Lys Thr Glu Ala Ile Ser Ile Leu Asn Glu Ala Phe Ser Glu 
                325                 330                 335     


Leu Gly Val Leu Glu Gly Asp Cys Lys Glu Met Ser Trp Ile Glu Ser 
            340                 345                 350         


Thr Leu Phe Phe Ser Glu Leu Asp Asp Val Ala Asn Ser Ser Asp Val 
        355                 360                 365             


Ser Arg Leu Lys Glu Arg Tyr Phe Glu Asn Lys Ser Tyr Phe Lys Ala 
    370                 375                 380                 


Lys Ser Asp Tyr Val Lys Thr Pro Ile Ser Val Gly Gly Ile Met Thr 
385                 390                 395                 400 


Ala Leu Asn Val Leu Glu Lys Glu Pro Asn Gly His Val Ile Leu Asp 
                405                 410                 415     


Pro Tyr Gly Gly Ala Met Gln Arg Ile Ser Glu Glu Ala Ile Ala Phe 
            420                 425                 430         


Pro His Arg Lys Gly Asn Leu Phe Gly Ile Gln Tyr Leu Val Val Trp 
        435                 440                 445             


Lys Glu Lys Asp Asn Asn Asn Ile Val Lys Ser Asn Ile Gly Tyr Ile 
    450                 455                 460                 


Glu Trp Ile Arg Glu Phe Tyr Asn Thr Met Ala Pro His Val Ser Ser 
465                 470                 475                 480 


Ser Pro Arg Ala Ala Tyr Val Asn Tyr Met Asp Leu Asp Leu Gly Val 
                485                 490                 495     


Met Asp Asp Tyr Leu Leu Pro Cys Thr Ser Thr Thr Ala Ser Ala Asn 
            500                 505                 510         


His Ala Val Glu Arg Ala Arg Val Trp Gly Glu Lys Tyr Phe Leu Asn 
        515                 520                 525             


Asn Tyr Asp Arg Leu Val Lys Ala Lys Thr Lys Ile Asp Pro Leu Asn 
    530                 535                 540                 


Val Phe Arg His Gln Gln Gly Ile Pro Pro Leu Phe Ala Ser Met Gln 
545                 550                 555                 560 


Glu Tyr Thr Tyr Ser Ser Lys 
                565         


<210>  5
<211>  566
<212>  PRT
<213>  Nicotiana tabacum

<400>  5

Met Lys Arg Asn Ile Ser Met Ser Leu Gln Arg Leu Leu Ile Ile Leu 
1               5                   10                  15      


Met Met Ile Ser Phe Leu Phe Thr Ser Leu Leu Val Pro Ser Val Ser 
            20                  25                  30          


Ala Thr Asn Leu Asn Thr Ile Ser Thr Cys Leu Ile Asn Tyr Lys Val 
        35                  40                  45              


Ser Asn Phe Ser Val Tyr Pro Thr Arg Asn His Ala Gly Asn Arg Tyr 
    50                  55                  60                  


Tyr Asn Leu Leu Asp Phe Ser Ile Gln Asn Leu Arg Phe Ala Ala Ser 
65                  70                  75                  80  


Ser Lys Pro Lys Pro Thr Val Ile Ile Val Pro Glu Ser Lys Glu Gln 
                85                  90                  95      


Leu Val Ser Ser Val Leu Cys Cys Arg Gln Gly Ser Tyr Glu Ile Arg 
            100                 105                 110         


Val Arg Cys Gly Gly His Ser Tyr Glu Gly Thr Ser Tyr Val Ser Phe 
        115                 120                 125             


Asp Gly Ser Pro Phe Val Val Ile Asp Leu Met Lys Leu Asp Asp Val 
    130                 135                 140                 


Ser Val Asp Leu Asp Ser Glu Thr Ala Trp Val Gln Gly Gly Ala Thr 
145                 150                 155                 160 


Leu Gly Gln Thr Tyr Tyr Ala Ile Ser Arg Ala Ser Asp Val His Gly 
                165                 170                 175     


Phe Ser Ala Gly Ser Cys Pro Thr Val Gly Val Gly Gly His Ile Ser 
            180                 185                 190         


Gly Gly Gly Phe Gly Phe Leu Ser Arg Lys Tyr Gly Leu Ala Ala Asp 
        195                 200                 205             


Asn Val Val Asp Ala Leu Leu Val Asp Ala Glu Gly Arg Leu Leu Asp 
    210                 215                 220                 


Arg Lys Ala Met Gly Glu Glu Val Phe Trp Ala Ile Arg Gly Gly Gly 
225                 230                 235                 240 


Gly Gly Ile Trp Gly Ile Ile Tyr Ala Trp Lys Ile Arg Leu Leu Lys 
                245                 250                 255     


Val Pro Lys Thr Val Thr Ser Phe Ile Val Pro Arg Pro Gly Ser Lys 
            260                 265                 270         


Arg Tyr Val Ser Gln Leu Val His Lys Trp Gln Leu Val Ala Pro Lys 
        275                 280                 285             


Leu Asp Asp Asp Phe Tyr Leu Ser Ile Ser Met Ser Ser Ala Ser Lys 
    290                 295                 300                 


Gly Asn Ile Pro Ile Glu Ile Asn Ala Gln Phe Ser Gly Phe Tyr Leu 
305                 310                 315                 320 


Gly Thr Lys Thr Glu Ala Ile Ser Ile Leu Asn Glu Ala Phe Pro Glu 
                325                 330                 335     


Leu Gly Val Val Glu Ser Asp Cys Lys Glu Met Ser Trp Ile Glu Ser 
            340                 345                 350         


Thr Leu Phe Phe Ser Glu Leu Asp Asn Val Ala Asn Thr Ser Asp Val 
        355                 360                 365             


Ser Arg Leu Lys Glu Arg Tyr Phe Glu Asn Lys Ser Tyr Phe Lys Ala 
    370                 375                 380                 


Lys Ser Asp His Val Lys Thr Pro Ile Ser Val Gly Gly Ile Met Thr 
385                 390                 395                 400 


Ala Leu Asp Val Leu Glu Lys Glu Pro Asn Gly His Val Ile Phe Asp 
                405                 410                 415     


Pro Tyr Gly Ala Ala Met Gln Arg Ile Ser Glu Glu Ala Ile Ala Phe 
            420                 425                 430         


Pro His Arg Lys Gly Asn Leu Phe Arg Ile Gln Tyr Leu Val Val Trp 
        435                 440                 445             


Lys Glu Lys Asp Asn Asn Asn Ile Ala Lys Ser Asn Gly Tyr Ile Glu 
    450                 455                 460                 


Trp Ile Arg Glu Phe Tyr Asn Thr Met Ala Pro His Val Ser Ser Ser 
465                 470                 475                 480 


Pro Arg Ala Ala Tyr Val Asn Tyr Met Asp Leu Asp Leu Gly Val Met 
                485                 490                 495     


Asp Asp Tyr Leu Met Leu Asn Thr Ser Ile Thr Ala Ser Ala Asp His 
            500                 505                 510         


Ala Val Glu Arg Ala Arg Val Trp Gly Glu Lys Tyr Phe Leu Asn Asn 
        515                 520                 525             


Tyr Asp Arg Leu Val Lys Ala Lys Thr Lys Ile Asp Pro Leu Asn Val 
    530                 535                 540                 


Phe Arg His Gln Gln Gly Ile Pro Pro Met Phe Ala Ser Met Pro Glu 
545                 550                 555                 560 


His Thr Tyr Ser Ser Lys 
                565     


<210>  6
<211>  565
<212>  PRT
<213>  Nicotiana tabacum

<400>  6

Met Phe Pro Ile Ile Ile Leu Ile Ser Phe Ser Phe Thr Phe Leu Phe 
1               5                   10                  15      


Ala Ser Val Thr Ser Gly Ala Gly Gly Val Thr Asn Leu Ser Thr Cys 
            20                  25                  30          


Leu Ile Asn His Asn Val His Asn Phe Ser Ile Tyr Pro Thr Lys Asn 
        35                  40                  45              


Asp Gln Ser Ser Ser Asn Tyr Phe Asn Leu Leu Asp Phe Ser Leu Gln 
    50                  55                  60                  


Asn Leu Arg Phe Ala Ala Ser Tyr Met Pro Lys Pro Thr Val Ile Ile 
65                  70                  75                  80  


Leu Pro Asn Ser Lys Glu Glu Leu Val Ser Thr Ile Leu Cys Cys Arg 
                85                  90                  95      


Gln Thr Ser Tyr Glu Ile Arg Val Arg Cys Gly Gly His Ser Tyr Glu 
            100                 105                 110         


Gly Thr Ser Tyr Val Ser Phe Asp Gly Ser Pro Phe Val Ile Val Asp 
        115                 120                 125             


Leu Met Lys Leu Asp Asp Val Ser Val Asp Leu Asp Ser Glu Thr Ala 
    130                 135                 140                 


Trp Ala Gln Gly Gly Ala Thr Ile Gly Gln Ile Tyr Tyr Ala Ile Ser 
145                 150                 155                 160 


Arg Val Ser Asp Val His Ala Phe Ser Ala Gly Ser Gly Pro Thr Val 
                165                 170                 175     


Gly Ser Gly Gly His Ile Ser Gly Gly Gly Phe Gly Leu Met Ser Arg 
            180                 185                 190         


Lys Phe Gly Leu Ala Ala Asp Ser Val Val Asp Ala Leu Leu Ile Asp 
        195                 200                 205             


Ala Glu Gly Arg Leu Leu Asp Arg Lys Ala Met Gly Glu Asp Val Phe 
    210                 215                 220                 


Trp Ala Ile Arg Gly Gly Gly Gly Gly Asn Trp Gly Ile Ile Tyr Ala 
225                 230                 235                 240 


Trp Lys Ile Arg Leu Leu Lys Val Pro Lys Ile Val Thr Thr Cys Met 
                245                 250                 255     


Ile Tyr Arg Pro Gly Ser Lys Gln Tyr Val Ala Gln Leu Leu Gln Lys 
            260                 265                 270         


Trp Gln Ile Val Thr Pro Asn Leu Ala Asp Asp Phe Thr Leu Gly Val 
        275                 280                 285             


Leu Met Arg Pro Ile Asp Leu Arg Ala Asp Met Asn Tyr Gly Asn Thr 
    290                 295                 300                 


Thr Pro Ile Glu Thr Phe Pro Gln Phe Asn Ala Leu Tyr Leu Gly Pro 
305                 310                 315                 320 


Lys Thr Glu Ala Val Ser Ile Leu Asn Glu Ala Phe Pro Glu Leu Asp 
                325                 330                 335     


Ala Lys Asn Asp Asp Ala Lys Glu Met Thr Trp Ile Glu Ser Ala Leu 
            340                 345                 350         


Phe Phe Ser Glu Leu Asp Asn Val Phe Gly Asn Ser Ser Asp Asp Ile 
        355                 360                 365             


Ser Arg Leu Lys Glu Arg Tyr Met Asp Ala Lys Thr Phe Phe Lys Gly 
    370                 375                 380                 


Lys Ser Asp Phe Val Lys Thr Pro Phe Ser Met Asp Ala Met Met Thr 
385                 390                 395                 400 


Ala Leu Val Glu Leu Glu Lys Asn Pro Lys Ser Phe Leu Val Phe Asp 
                405                 410                 415     


Pro Tyr Gly Gly Val Met Asp Lys Ile Ser Asp Gln Ala Ile Ala Phe 
            420                 425                 430         


Pro His Arg Lys Gly Asn Leu Phe Ala Val Gln Tyr Tyr Ala Phe Trp 
        435                 440                 445             


Asn Glu Glu Asp Asp Ala Lys Ser Asn Glu Tyr Ile Glu Trp Thr Arg 
    450                 455                 460                 


Gly Phe Tyr Asn Lys Met Ala Pro Phe Val Ser Ser Ser Pro Arg Gly 
465                 470                 475                 480 


Ala Tyr Ile Asn Tyr Leu Asp Met Asp Leu Gly Val Asn Met Asp Asp 
                485                 490                 495     


Asp Tyr Leu Leu Arg Asn Ala Ser Ser Arg Ser Ser Ser Ser Ser Val 
            500                 505                 510         


Asp Ala Val Glu Arg Ala Arg Ala Trp Gly Glu Met Tyr Phe Leu His 
        515                 520                 525             


Asn Tyr Asp Arg Leu Val Lys Ala Lys Thr Gln Ile Asp Pro Leu Asn 
    530                 535                 540                 


Val Phe Arg His Glu Gln Ser Ile Pro Pro Met Leu Gly Ser Thr Gln 
545                 550                 555                 560 


Glu His Ser Ser Glu 
                565 


<210>  7
<211>  22
<212>  DNA
<213>  Nicotiana tabacum

<400>  7
gaggagctcg tgagtaccat tc                                                22


<210>  8
<211>  22
<212>  DNA
<213>  Nicotiana tabacum

<400>  8
gtcattatcg taccagagag ca                                                22


<210>  9
<211>  83
<212>  DNA
<213>  Nicotiana tabacum

<400>  9
catcttacat gccgaaacca acggtcatta tcctaccaaa cagcaaagag gagctcgtga       60

gtaccattct ttgttgcaga caa                                               83


<210>  10
<211>  77
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated BBL nucletotide sequence

<400>  10
catcttacat gccgaaacca acggtcatta tcctaccaaa cagcaaagag gagggtacca       60

ttctttgttg cagacaa                                                      77


<210>  11
<211>  81
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated BBL nucletotide sequence

<400>  11
catcttacat gccgaaacca acggtcatta tcctaccaaa cagcaaagag gagctcgagt       60

accattcttt gttgcagaca a                                                 81


<210>  12
<211>  74
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated BBL nucletotide sequence

<400>  12
catcttacat gccgaaacca acggtcatta tcctaccaaa cagcaaagag agtaccattc       60

tttgttgcag acaa                                                         74


<210>  13
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated BBL nucletotide sequence

<400>  13
catctattaa ccccacaaag aatgatcaaa gtaagtacca ttctttgttg cagacaa          57


<210>  14
<211>  75
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated BBL nucletotide sequence

<400>  14
catcttacat gccgaaacca acggtcatta tcctaccaaa cagcaaagag gagcttctta       60

cacttgtgca gacaa                                                        75


<210>  15
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated BBL nucletotide sequence

<400>  15
catcttacat gccgaaacca acggtcatta tcctaccaaa cagcaaagag gattctttgt       60

tgcagacaa                                                               69


<210>  16
<211>  82
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated BBL nucletotide sequence

<400>  16
catcttacat gccgaaacca acggtcatta tcctaccaaa cagcaaagag gagctcggag       60

taccattctt tgttgcagac aa                                                82


<210>  17
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated BBL nucletotide sequence

<400>  17
catcttacat gccgaaacca acggtcatta tccattcttt gttgcagaca a                51


<210>  18
<211>  72
<212>  DNA
<213>  Nicotiana tabacum

<400>  18
tctccgattc gcagcgtgct ctaaaccaaa accaactgtc attatcgtac cagagagcaa       60

ggagcagctg gt                                                           72


<210>  19
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated BBL nucletotide sequence

<400>  19
aactagtcta aaccagagag caaggagcag ctggt                                  35


<210>  20
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated BBL nucletotide sequence

<400>  20
tctccgattc gcagcgtgct ctaaaccaaa actaccagag agcaaggagc agctggt          57


<210>  21
<211>  71
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated BBL nucletotide sequence

<400>  21
tctccgattc gcagcgtgct ctaaaccaaa accaactgtc attatcgtac agagagcaag       60

gagcagctgg t                                                            71


<210>  22
<211>  54
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated BBL nucletotide sequence

<400>  22
tctccgattc gcagcgtgct ctaaaccaaa accaactgtc aaggagcagg tggt             54


<210>  23
<211>  84
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated BBL nucletotide sequence

<400>  23
tctccgattc gcagcgtgct ctaaaccaaa accaactgtc attatagtaa ctatcattaa       60

accagagagc aaggagcagc tggt                                              84


<210>  24
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated BBL nucletotide sequence

<400>  24
tctccgattc gcagcgtata ccagagagca aggagcagct ggt                         43


<210>  25
<211>  53
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated BBL nucletotide sequence

<400>  25
tctccgattc gcagcgtgct ctaaaccaaa accaactgtc attatcgtaa ggt              53


<210>  26
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated BBL nucletotide sequence

<400>  26
tctccgattc gcagcgtgct ctaaaccaaa accaactgtc gcagtaccag agagcaagga       60

gcagctggt                                                               69


<210>  27
<211>  72
<212>  DNA
<213>  Nicotiana tabacum

<400>  27
tctccgattc gcagcgtcct ctaaaccaaa accaacggtc attatcgtac cagagagcaa       60

ggagcagctg gt                                                           72


<210>  28
<211>  67
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated BBL nucletotide sequence

<400>  28
tctccgattc gcagcgtcct ctaaaccaaa accaacggtc attaccagag agcaaggagc       60

agctggt                                                                 67


<210>  29
<211>  44
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated BBL nucletotide sequence

<400>  29
tctccgattc gcagcgtcct ctaatgaaat cagagtaagc tggt                        44


<210>  30
<211>  84
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated BBL nucletotide sequence

<400>  30
tctccgattc gcagcgtcct ctaaaccaaa accaacggtc attatcgtac acagttatga       60

agcgttctgg agagcaagga gcag                                              84


<210>  31
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated BBL nucletotide sequence

<400>  31
tctccgattc gcagcgtcct ctaaaccaaa accaaggagc agctggt                     47


<210>  32
<211>  67
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated BBL nucletotide sequence

<400>  32
tctccgattc gcagcgtcct ctaaaccaaa accaacggtc attatcagag agcaaggagc       60

agctggt                                                                 67


<210>  33
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated BBL nucletotide sequence

<400>  33
tctccgattc gcagcgtcct ctaaaccaaa accaacgtta aaaaaggagc agctggt          57


<210>  34
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated BBL nucletotide sequence

<400>  34
tctccgattc gcagcgtcct ctaaaccaaa accaacgaac agctggt                     47


<210>  35
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated BBL nucletotide sequence

<400>  35
tctccgattc gcagagacca aggagccgct ggt                                    33


<210>  36
<211>  58
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated BBL nucletotide sequence

<400>  36
tctccgattc gcagcgtcct ctaaaccaaa accaaccaga gagcaaggag cagctggt         58


<210>  37
<211>  56
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated BBL nucletotide sequence

<400>  37
tctccgattc gcagcgtcct ctaaaccaaa accaacggtc attatcgtac gctggt           56


