                               SEQUENCE LISTING

<110> ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE 
      UNIVERSITY
 
<120> HUMAN ALZHEIMER'S DISEASE AND TRAUMATIC BRAIN INJURY ASSOCIATED 
      TAU VARIANTS AS BIOMARKERS AND METHODS OF USE THEREOF

<130> 17555.036WO1

<140> PCT/US2016/065908
<141> 2016-12-09

<150> 62/266,461
<151> 2015-12-11

<160> 57    

<170> PatentIn version 3.5

<210> 1
<211> 912
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (28)..(28)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (41)..(41)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (59)..(59)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (68)..(68)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (71)..(71)
<223> a, c, t, g, unknown or other

<400> 1
gattacngcc aagcttgcat gcaaattnta tttcaaggag ncagtcataa tgaaatacnt       60

attgcctncg ncagccgctg gattgttatt actcgcggcc cagccggcca tggccgaggt      120

gcagctgttg gagtctgggg gaggcttggt acagcctggg gggtccctga gactctcctg      180

tgcagcctct ggattcacct ttagcagcta tgccatgagc tgggtccgcc aggctccagg      240

gaaggggctg gagtgggtct catctatttc ttctaatggt gatgatacag cttacgcaga      300

ctccgtgaag ggccggttca ccatctccag agacaattcc aaggacacgc tgtatctgca      360

aatgaacagc ctgagagccg aggacacggc cgtatattac tgtgcgaaag ctaataattc      420

ttttgactac tggggccagg gaaccctggt caccgtctcg agcggtggag gcggttcagg      480

cggaggtggc agcggcggtg gcgggtcgac ggacatccag atgacccagt ctccatcctc      540

cctgtctgca tctgtaggag acagagtcac catcacttgc cgggcaagtc agagcattag      600

cagctattta aattggtatc agcagaaacc agggaaagcc cctaagctcc tgatctataa      660

tgcatccact ttgcaaagtg gggtcccatc aaggttcagt ggcagtggat ctgggacaga      720

tttcactctc accatcagca gtctgcaacc tgaagatttt gcaacttact actgtcaaca      780

ggatagtgct actccttata cgttcggcca agggaccaag gtggaaatca aacgggcggc      840

cgcacatcat catcaccatc acggggccgc agaacaaaaa ctcatctcag aagaggatct      900

gaatggggcc gc                                                          912


<210> 2
<211> 287
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(8)
<223> Any amino acid

<400> 2
Met Lys Tyr Xaa Leu Pro Xaa Xaa Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Ser Asn Gly Asp Asp Thr 
65                  70                  75                  80  


Ala Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asp Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Ala Asn Asn Ser Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asn Ala Ser Thr Leu 
        195                 200                 205             


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Asp Ser Ala Thr Pro Tyr Thr Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Val Glu Ile Lys Arg Ala Ala Ala His His His His His His Gly 
            260                 265                 270         


Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala 
        275                 280                 285         


<210> 3
<211> 927
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (6)..(6)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (25)..(26)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (34)..(35)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (37)..(37)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (76)..(76)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (81)..(81)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (90)..(91)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (112)..(112)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (141)..(141)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (220)..(220)
<223> a, c, t, g, unknown or other

<400> 3
tatganccat gattacgcca agctnncatg caanntntat tttcaaggag acagtcataa       60

tgaaatacct attgcntacg ncagccgctn ngattgttat tactcgcggc cncagccggc      120

catggccgag gtgcagctgt nggagtctgg gggaggcttg gtacagcctg gggggtccct      180

gagactctcc tgtgcagcct ctggattcac ctttagcagn tatgccatga gctgggtccg      240

ccaggctcca gggaaggggc tggagtgggt ctcatagatt tagcagtcgg gtccggttac      300

atcttacgca gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac      360

gctgtatctg caaatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgcgaa      420

acgtcagttg atgtttgact actggggcca gggaaccctg gtcaccgtct cgagcggtgg      480

aggcggttca ggcggaggtg gcagcggcgg tggcgggtcg acggacatcc agatgaccca      540

gtctccatcc tccctgtctg catctgtagg agacagagtc accatcactt gccgggcaag      600

tcagagcatt agcagctatt taaattggta tcagcagaaa ccagggaaag cccctaagct      660

cctgatctat gctgcatcca gtttgcaaag tggggtccca tcaaggttca gtggcagtgg      720

atctgggaca gatttcactc tcaccatcag cagtctgcaa cctgaagatt ttgcaactta      780

ctactgtcaa cagagttaca gtacccctaa tacgttcggc caagggacca aggtggaaat      840

caaacgggcg gccgcacatc atcatcacca tcacggggcc gcagaacaaa aactcatctc      900

agaagaggat ctgaatgggc cgcatag                                          927


<210> 4
<211> 266
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Any amino acid

<400> 4
Met Ala Glu Val Gln Leu Xaa Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Xaa Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Ile Gln Ser Gly Pro Val Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Gln Leu Met Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Thr Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
    130                 135                 140                 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
145                 150                 155                 160 


Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
                165                 170                 175     


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        195                 200                 205             


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
    210                 215                 220                 


Ser Thr Pro Asn Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
225                 230                 235                 240 


Ala Ala Ala His His His His His His Gly Ala Ala Glu Gln Lys Leu 
                245                 250                 255     


Ile Ser Glu Glu Asp Leu Asn Gly Pro His 
            260                 265     


<210> 5
<211> 833
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (4)..(4)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(15)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (28)..(28)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (34)..(34)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (37)..(37)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (67)..(67)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (71)..(77)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (101)..(102)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (177)..(177)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (189)..(189)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (221)..(222)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (253)..(258)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (261)..(261)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (745)..(745)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (771)..(771)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (794)..(794)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (800)..(800)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (810)..(810)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (814)..(816)
<223> a, c, t, g, unknown or other

<400> 5
attncgccaa gctnncatgc aaaatttnta tttnaangga gacagtcata atgaaatacc       60

tattgcntac nnnnnnncgc tggattgtta ttactcgcgg nncagccggc catggccgag      120

gtgcagctgt tggagtctgg gggaggcttg gtacagcctg gggggtccct gagactntcc      180

tgtgcagcnt ctggattcac ctttagcagc tatgccatga nntgggtccg ccaggctcca      240

gggaaggggc tgnnnnnngt ntcatctatt acgtagacgg gttcgtagac acagtacgca      300

gactccgtga agggcaggtt caccatctcc agagacaatt ccaagaacac gctgtatctg      360

caaatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgcgaa acagcatgat      420

gattttgact actggggcca gggaaccctg gtcaccgtct cgagcggtgg aggcggttca      480

ggcggaggtg gcagcggcgg tggcgggtcg acggacatcc agatgaccca gtctccatcc      540

tccctgtctg catctgtagg agacagagtc accatcactt gccgggcaag tcagagcatt      600

agcagctatt taaattggta tcagcagaaa ccagggaaag cccctaagct cctgatctat      660

actgcatcca atttgcaaag tggggtccca tcaaggttca gtggcagtgg atctgggaca      720

gatttcactc tcaccatcag cagtntgcaa cctgaagatt ttgcaactta ntactgtcaa      780

cagctggatg tgtntccttn gacgttcggn caannnacca aggtggaaat caa             833


<210> 6
<211> 238
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (48)..(50)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Any amino acid

<400> 6
Met Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Xaa Ser Cys Ala Xaa Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Ser Tyr Ala Met Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Xaa 
        35                  40                  45              


Xaa Xaa Ser Ser Ile Thr Thr Gly Ser Thr Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gln His Asp Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Thr Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
    130                 135                 140                 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
145                 150                 155                 160 


Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
                165                 170                 175     


Lys Leu Leu Ile Tyr Thr Ala Ser Asn Leu Gln Ser Gly Val Pro Ser 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        195                 200                 205             


Ser Xaa Gln Pro Glu Asp Phe Ala Thr Xaa Tyr Cys Gln Gln Leu Asp 
    210                 215                 220                 


Val Xaa Pro Xaa Thr Phe Xaa Gln Xaa Thr Lys Val Glu Ile 
225                 230                 235             


<210> 7
<211> 963
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (29)..(29)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (660)..(660)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (690)..(690)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (763)..(763)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (853)..(853)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (861)..(862)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (872)..(874)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (876)..(877)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (898)..(898)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (912)..(912)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (914)..(916)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (954)..(954)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (957)..(958)
<223> a, c, t, g, unknown or other

<400> 7
gagacagtca tagctagcat gaaaaagant tggctggcgc tggctggttt agttttagcg       60

tttagcgcat cggcggacta caaagaggcc cagccggcca tggacctggg taagaaactg      120

ctggaagctg ctcgtgctgg tcaggacgac gaagttcgta tcctgatggc taacggtgct      180

gacgttaacg ctgacgacta cgaaggttgg actccgctgc acctggctgc tatggttggt      240

cacctggaaa tcgttgaagt tctgctgaag tacggtgctg acgttaacgc tcaggacaaa      300

ttcggtaaga ccgctttcga catctccatc gacaacggta acgaggacct ggctgaaatc      360

ctgcaagcgg ccgcacatca tcatcaccat cacggggccg cagaacaaaa actcatctca      420

gaagaggatc tgaatggggc cgcatagact gttgaaagtt gtttagcaaa acctcataca      480

gaaaattcat ttactaacgt ctggaaagac gacaaaactt tagatcgtta cgctaactat      540

gagggctgtc tgtggaatgc tacaggcgtt gtggtttgta ctggtgacga aactcagtgt      600

tacggtacat gggttcctat tgggcttgct atccctgaaa atgagggtgg tggctctgan      660

ggtggcggtt ctgagggtgg cggttctgan ggtggcggta ctaaacctcc tgagtacggt      720

gatacaccta ttccgggcta tacttatatc aaccctctcg acngcactta tccgcctggt      780

actgagcaaa accccgctaa tcctaatccc ttctcttgag gagtctcagc ctcttaatac      840

tttcatgttt canaataata nnttccgaaa tnnncnnggt gcattaactg tttatacngg      900

cactgttact cnannnactg acccccgttt aaaacttatt accagtacac tccntgnnat      960

cat                                                                    963


<210> 8
<211> 142
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<400> 8
Met Lys Lys Xaa Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 
1               5                   10                  15      


Ala Ser Ala Asp Tyr Lys Glu Ala Gln Pro Ala Met Asp Leu Gly Lys 
            20                  25                  30          


Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile 
        35                  40                  45              


Leu Met Ala Asn Gly Ala Asp Val Asn Ala Asp Asp Tyr Glu Gly Trp 
    50                  55                  60                  


Thr Pro Leu His Leu Ala Ala Met Val Gly His Leu Glu Ile Val Glu 
65                  70                  75                  80  


Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly 
                85                  90                  95      


Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala 
            100                 105                 110         


Glu Ile Leu Gln Ala Ala Ala His His His His His His Gly Ala Ala 
        115                 120                 125             


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala 
    130                 135                 140         


<210> 9
<211> 890
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (67)..(67)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (778)..(778)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (799)..(799)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (814)..(814)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (822)..(823)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (843)..(844)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (866)..(867)
<223> a, c, t, g, unknown or other

<400> 9
ttcaggagan agtcntaatg aaatacctat tgcctacggc agccgctgga ttgttattac       60

tcgcggncca gccggccatg gccgaggtgc agctgttgga gtctggggga ggcttggtac      120

agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttt agcagctatg      180

ccatgagctg ggtccgccag gctccaggga aggggctgga gtgggtctca ggtatttcta      240

ataatggtag taatacaact tacgcagact ccgtgaaggg ccggttcacc atctccagag      300

acaattccaa gaacacgctg tatctgcaaa tgaacagcct gagagccgag gacacggccg      360

tatattactg tgcgaaagct tcttatactt ttgactactg gggccaggga accctggtca      420

ccgtctcgag cggtggaggc ggttcaggcg gaggtggcag cggcggtggc gggtcgacgg      480

acatccagat gacccagtct ccatcctccc tgtctgcatc tgtaggagac agagtcacca      540

tcacttgccg ggcaagtcag agcattagca gctatttaaa ttggtatcag cagaaaccag      600

ggaaagcccc taagctcctg atctatagtg catcctcttt gcaaagtggg gtcccatcaa      660

ggttcagtgg cagtggatct gggacagatt tcactctcac catcagcagt ctgcaacctg      720

aagattttgc aacttactac tgtcaacagt attctggttc tcctgctacg ttcggccnag      780

ggaccaaggt ggaaatcana cgggcggccg cacntcatca tnnccatcac ggggccgcag      840

aannaaaact catctcagaa gagganntga atggggccgc atagactgtt                 890


<210> 10
<211> 283
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Any amino acid

<400> 10
Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Xaa Gln Pro Ala Met Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Gly Ile Ser Asn Asn Gly Ser Asn Thr 
65                  70                  75                  80  


Thr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Ala Ser Tyr Thr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu 
        195                 200                 205             


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Tyr Ser Gly Ser Pro Ala Thr Phe Gly Xaa Gly Thr 
                245                 250                 255     


Lys Val Glu Ile Xaa Arg Ala Ala Ala Xaa His His Xaa His His Gly 
            260                 265                 270         


Ala Ala Glu Xaa Lys Leu Ile Ser Glu Glu Xaa 
        275                 280             


<210> 11
<211> 883
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (23)..(23)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (51)..(51)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (53)..(54)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (86)..(86)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (154)..(154)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (172)..(172)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (267)..(267)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (434)..(434)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (447)..(447)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (529)..(529)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (546)..(546)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (555)..(556)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (581)..(581)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (584)..(584)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (620)..(620)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (639)..(639)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (645)..(645)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (672)..(672)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (700)..(700)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (734)..(734)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (754)..(755)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (764)..(764)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (766)..(766)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (785)..(785)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (787)..(788)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (797)..(797)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (799)..(799)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (802)..(802)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (815)..(815)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (817)..(817)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (819)..(823)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (826)..(826)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (828)..(830)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (837)..(837)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (839)..(839)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (854)..(855)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (860)..(860)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (868)..(868)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (872)..(874)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (876)..(876)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (880)..(880)
<223> a, c, t, g, unknown or other

<400> 11
ttcagganan agtcataatg aantacctat tgcctacggc agccgctgga ntnntattac       60

tcgcggccca gccggccatg gcccangtgc agctggtgga gtctggggga ggcgtggtcc      120

agcctgggag gtccctgaga ctctcctgtg cagnctccgg attcaccttt ancagctatg      180

acatgggctg ggtccgccag gctccaggga aggggctgga gtgggtctca agtattagtg      240

gtagtggtcc taccatgaac tacgcanact ctgtgaaggg ccgattcacc gtctccagag      300

acaattccaa gaacacgctg tatctgcaaa tggacagcct gagagccgag gacacggccg      360

tatattactg tgcgaaaggg ggtacggact ttgactactg gggccagggc accctggtca      420

ccgtctcctc aggnggaggc ggttcangcg gaggtggctc tggcggtggc ggatcgtctg      480

agctgactca ggaccctgct gtgtctgtgg ccttgggaca gacagtcanc atcacatgcc      540

aagganacag cctcnnaacc tattatgcaa gctggtacca ncanaagcca ggacaggccc      600

ctgtacttgt catctatggn aaaaacaacc ggccctcang gatcncagac cgattctctg      660

gctccagctc angaaacaca gcttccttga ccatcactgn ggctcaggcg gaagatgagg      720

ctgactatta ctgnaactcc cgggacagca gtgnnaacca tctnangagt gttcggcgga      780

gggancnngc tgaccgncnt angtgcggcc gcagnancnn nnnctncnnn tcagaanang      840

atctgaatgg ggcnncatan actgttgnaa annngnttan caa                        883


<210> 12
<211> 255
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(13)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (188)..(189)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (249)..(250)
<223> Any amino acid

<400> 12
Met Xaa Tyr Leu Leu Pro Thr Ala Ala Ala Gly Xaa Xaa Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Xaa Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Xaa Ser Gly 
        35                  40                  45              


Phe Thr Phe Xaa Ser Tyr Asp Met Gly Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Pro Thr Met 
65                  70                  75                  80  


Asn Tyr Ala Xaa Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asp Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Gly Gly Thr Asp Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Xaa Gly Gly Gly Ser Xaa 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro 
145                 150                 155                 160 


Ala Val Ser Val Ala Leu Gly Gln Thr Val Xaa Ile Thr Cys Gln Gly 
                165                 170                 175     


Xaa Ser Leu Xaa Thr Tyr Tyr Ala Ser Trp Tyr Xaa Xaa Lys Pro Gly 
            180                 185                 190         


Gln Ala Pro Val Leu Val Ile Tyr Xaa Lys Asn Asn Arg Pro Ser Xaa 
        195                 200                 205             


Ile Xaa Asp Arg Phe Ser Gly Ser Ser Ser Xaa Asn Thr Ala Ser Leu 
    210                 215                 220                 


Thr Ile Thr Xaa Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Xaa Asn 
225                 230                 235                 240 


Ser Arg Asp Ser Ser Xaa Asn His Xaa Xaa Ser Val Arg Arg Arg 
                245                 250                 255 


<210> 13
<211> 854
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (651)..(651)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (751)..(752)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (760)..(760)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (766)..(767)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (776)..(776)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (778)..(778)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (780)..(780)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (787)..(789)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (791)..(794)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (801)..(802)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (816)..(817)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (821)..(821)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (824)..(828)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (831)..(831)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (833)..(833)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (836)..(839)
<223> a, c, t, g, unknown or other

<400> 13
ttcaggagan agtcntaatg aaatacctat tgcctacggc agccgctgga ttgttattac       60

tcgcggccca gccggccatg gccgaggtgc agctgttgga gtctggggga ggcttggtac      120

agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttt agcagctatg      180

ccatgagctg ggtccgccag gctccaggga aggggctgga gtgggtctca gctattacta      240

atgatggtgc tggtacaact tacgcagact ccgtgaaggg ccggttcacc atctccagag      300

acaattccaa gaacacgctg tatctgcaaa tgaacagcct gagagccgag gacacggccg      360

tatattactg tgcgaaatct tatactggtt ttgactactg gggccaggga accctggtca      420

ccgtctcgag cggtggaggc ggttcaggcg gaggtggcag cggcggtggc gggtcgacgg      480

acatccagat gacccaatct ccatcctccc tgtctgcatc tgtaggagac agagtcacca      540

tcacttgccg ggcaagtcag agcattagca gctatttaaa ttggtatcag cagaaaccag      600

ggaaagcccc taagctcctg atctatactg catccacttt gcaaagtggg ntcccattaa      660

ggttcagtgg cagtggatct gggacagatt tcactctcac catcagcagt ctgcaacctg      720

aagattttgc aacttactac tgtcaacaga nntatgctan tcctannacg ttcggncnan      780

gggaccnnng nnnnaaatca nncgggcggc cgcacnncat natnnnnnat ncncgnnnnc      840

gcagaacaaa actc                                                        854


<210> 14
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (212)..(212)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Any amino acid

<400> 14
Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Ala Ile Thr Asn Asp Gly Ala Gly Thr 
65                  70                  75                  80  


Thr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Ser Tyr Thr Gly Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Thr Ala Ser Thr Leu 
        195                 200                 205             


Gln Ser Gly Xaa Pro Leu Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Xaa Tyr Ala Xaa Pro Xaa Thr Phe 
                245                 250         


<210> 15
<211> 972
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (4)..(4)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (32)..(32)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (749)..(749)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (850)..(850)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (857)..(857)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (908)..(909)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (912)..(913)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (918)..(918)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (930)..(930)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (942)..(942)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (944)..(944)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (948)..(948)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (950)..(951)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (954)..(954)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (962)..(962)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (968)..(968)
<223> a, c, t, g, unknown or other

<400> 15
ctangcgncc nnttnagatc ctcttctgag angagttttt gttctgcggc cccgtgatgg       60

tgatgatgat gtgcggccgc ccgtttgatt tccaccttgg tcccttggcc gaacgtcgca      120

ggagtctgat gagtctgttg acagtagtaa gttgcaaaat cttcaggttg cagactgctg      180

atggtgagag tgaaatctgt cccagatcca ctgccactga accttgatgg gaccccactt      240

tgcaactggg atgccggata gatcaggagc ttaggggctt tccctggttt ctgctgatac      300

caatttaaat agctgctaat gctctgactt gcccggcaag tgatggtgac tctgtctcct      360

acagatgcag acagggagga tggagactgg gtcatctgga tgtccgtcga cccgccaccg      420

ccgctgccac ctccgcctga accgcctcca ccgctcgaga cggtgaccag ggttccctgg      480

ccccagtagt caaaagacca aaactgtttc gcacagtaat atacggccgt gtcctcggct      540

ctcaggctgt tcatttgcag atacagcgtg ttcttggaat tgtctctgga gatggtgaac      600

cggcccttca cggagtctgc gtacgttgtc ggcggaccct gcttcgcaat atctgagacc      660

cactccagcc ccttccctgg agcctggcgg acccagctca tggcatagct gctaaaggtg      720

aatccagagg ctgcacagga gagtctcang gaccccccag gctgtaccaa gcctccccca      780

gactccaaca gctgcacctc ggccatggcc ggctgggccg cgagtaataa caatccagcg      840

gctgccgtan gcaatangta tttcattatg actgtctcct tgaaatagaa tttgcatgca      900

agcttggnnt annatggnca tagctgtttn ctgtgtgaaa tngntatncn ntcncaattc      960

cncacaanat ac                                                          972


<210> 16
<211> 283
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Any amino acid

<400> 16
Met Lys Tyr Xaa Leu Xaa Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Xaa Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Asp Ile Ala Lys Gln Gly Pro Pro Thr 
65                  70                  75                  80  


Thr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Gln Phe Trp Ser Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Pro Ala Ser Gln Leu 
        195                 200                 205             


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Thr His Gln Thr Pro Ala Thr Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Val Glu Ile Lys Arg Ala Ala Ala His His His His His His Gly 
            260                 265                 270         


Ala Ala Glu Gln Lys Leu Xaa Ser Glu Glu Asp 
        275                 280             


<210> 17
<211> 980
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (6)..(6)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (22)..(22)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (739)..(739)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (840)..(840)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (880)..(880)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (903)..(903)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (910)..(910)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (942)..(942)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (950)..(950)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (955)..(955)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (957)..(957)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (961)..(961)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (970)..(970)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (978)..(978)
<223> a, c, t, g, unknown or other

<400> 17
cattcngatc ctcttctgag angagttttt gttctgcggc cccgtgatgg tgatgatgat       60

gtgcggccgc ccgtttgatt tccaccttgg tcccttggcc gaacgtaata ggagacggat      120

gcgactgttg acagtagtaa gttgcaaaat cttcaggttg cagactgctg atggtgagag      180

tgaaatctgt cccagatcca ctgccactga accttgatgg gaccccactt tgcaaattgg      240

atgccctata gatcaggagc ttaggggctt tccctggttt ctgctgatac caatttaaat      300

agctgctaat gctctgactt gcccggcaag tgatggtgac tctgtctcct acagatgcag      360

acagggagga tggagactgg gtcatctgga tgtccgtcga cccgccaccg ccgctgccac      420

ctccgcctga accgcctcca ccgctcgaga cggtgaccag ggttccctgg ccccagtagt      480

caaacgccgt ccaacgtttc gcacagtaat atacggccgt gtcctcggct ctcaggctgt      540

tcatttgcag atacagcgtg ttcttggaat tgtctctgga gatggtgaac cggcccttca      600

cggagtctgc gtaaattgtc ggactaccac ccccagcaat cgatgagacc cactccagcc      660

ccttccctgg agcctggcgg acccagctca tggcatagct gctaaaggtg aatccagagg      720

ctgcacagga gagtctcang gaccccccag gctgtaccaa gcctccccca gactccaaca      780

gctgcacctc ggccatggcc ggctgggccg cgagtaataa caatccagcg gctgccgtan      840

gcaataggta tttcattatg actgtctcct tgaaatagan tttgcatgca agcttggcgt      900

aantcatggn catagctgtt tcctgtgtga aattgttatc cnctcacaan ttccncncaa      960

ncatacgaan cccggaangc                                                  980


<210> 18
<211> 302
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Any amino acid

<400> 18
Met Xaa Met Xaa Tyr Ala Lys Leu Ala Cys Lys Xaa Tyr Phe Lys Glu 
1               5                   10                  15      


Thr Val Ile Met Lys Tyr Leu Leu Xaa Thr Ala Ala Ala Gly Leu Leu 
            20                  25                  30          


Leu Leu Ala Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu Glu Ser 
        35                  40                  45              


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Xaa Arg Leu Ser Cys Ala 
    50                  55                  60                  


Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln 
65                  70                  75                  80  


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ala Gly Gly Gly 
                85                  90                  95      


Ser Pro Thr Ile Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
            100                 105                 110         


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
        115                 120                 125             


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Arg Trp Thr Ala Phe 
    130                 135                 140                 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Asp Ile Gln 
                165                 170                 175     


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
            180                 185                 190         


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
        195                 200                 205             


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Arg Ala 
    210                 215                 220                 


Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
225                 230                 235                 240 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
                245                 250                 255     


Ala Thr Tyr Tyr Cys Gln Gln Ser His Pro Ser Pro Ile Thr Phe Gly 
            260                 265                 270         


Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Ala Ala His His His His 
        275                 280                 285             


His His Gly Ala Ala Glu Gln Lys Leu Xaa Ser Glu Glu Asp 
    290                 295                 300         


<210> 19
<211> 980
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (8)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (850)..(850)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (912)..(912)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (937)..(937)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (957)..(958)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (965)..(965)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (976)..(976)
<223> a, c, t, g, unknown or other

<400> 19
ctatgcgnnn nattcagatc ctcttctgag atgagttttt gttctgcggc cccgtgatgg       60

tgatgatgat gtgcggccgc ccgtttgatt tccaccttgg tcccttggcc gaacgtagga      120

ggcgaagtct gaacctgttg acagtagtaa gttgcaaaat cttcaggttg cagactgctg      180

atggtgagag tgaaatctgt cccagatcca ctgccactga accttgatgg gaccccactt      240

tgcaacaggg atgcacgata gatcaggagc ttaggggctt tccctggttt ctgctgatac      300

caatttaaat agctgctaat gctctggctt gcccggcaag tgatggtgac tctgtctcct      360

acagatgcag acagggagga tggagactgg gtcatctgga tgtccgtcga cccgccaccg      420

ccgctgccac ctccgcctga accgcctcca ccgctcgaga cggtgaccag ggttccctgg      480

ccccagtagt caaactgctt accacgtttc gcacagtaat atacggccgt gtcctcggct      540

ctcaggctgt tcatttgcag atacagcgtg ttcttggaat tgtctctgga gatggtgaac      600

cggcccttca cggagtctgc gtaatgtgtc acagtaccat ccggccaaat acctgagacc      660

cactccagcc ccttccctgg agcctggcgg acccagctca tggcatagct gctaaaggtg      720

aatccagagg ctgcacagga gagtctcagg gaccccccag gctgtaccaa gcctccccca      780

gactccaaca gctgcacctc ggccatggcc ggctgggccg cgagtaataa caatccagcg      840

gctgccgtan gcaataggta tttcattatg actgtctcct tgaaatagaa tttgcatgca      900

agcttggcgt antcatggtc atagctgttt cctgtgngaa attgttatcc gctcacnntt      960

ccacncaaca tacganccgg                                                  980


<210> 20
<211> 289
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (286)..(287)
<223> Any amino acid

<400> 20
Met Lys Tyr Leu Leu Xaa Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Gly Ile Trp Pro Asp Gly Thr Val Thr 
65                  70                  75                  80  


His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Arg Gly Lys Gln Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Arg Ala Ser Leu Leu 
        195                 200                 205             


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Val Gln Thr Ser Pro Pro Thr Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Val Glu Ile Lys Arg Ala Ala Ala His His His His His His Gly 
            260                 265                 270         


Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Xaa Xaa His 
        275                 280                 285             


Arg 
    


<210> 21
<211> 973
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (4)..(4)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (849)..(851)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (856)..(856)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (904)..(904)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (907)..(908)
<223> a, c, t, g, unknown or other

<400> 21
ctangcgnnn nnntcagatc ctcttctgag atgagttttt gttctgcggc cccgtgatgg       60

tgatgatgat gtgcggccgc ccgtttgatt tccaccttgg tcccttggcc gaacgtagaa      120

ggattatcat cattctgttg acagtagtaa gttgcaaaat cttcaggttg cagactgctg      180

atggtgagag tgaaatctgt cccagatcca ctgccactga accttgatgg gaccccactt      240

tgcaaagtgg atgcatcata aatcaggagc ttaggggctt tccctggttt ctgctgatac      300

caatttaaat agctgctaat gctctgactt gcccggcaag tgatggtgac tctgtctcct      360

acagatgcag acagggagga tggagactgg gtcatctgga tgtccgtcga cccgccaccg      420

ccgctgccac ctccgcctga accgcctcca ccgctcgaga cggtgaccag ggttccctgg      480

ccccagtagt caaaaccatt agaagttttc gcacagtaat atacggccgt gtcctcggct      540

ctcaggctgt tcatttgcag atacagcgtg ttcttggaat tgtctctgga gatggtgaac      600

cggcccttca cggagtctgc gtaatatgta gtactaccag tagcatcaat agttgagacc      660

cactccagcc ccttccctgg agcctggcgg acccagctca tggcatagct gctaaaggtg      720

aatccagagg ctgcacagga gagtctcagg gaccccccag gctgtaccaa gcctccccca      780

gactccaaca gctgcacctc ggccatggcc ggctgggccg cgagtaataa caatccagcg      840

gctgccgtnn naatangtat ttcattatga ctgtctcctt gaaatagaat ttgcatgcaa      900

gctnggnnta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc      960

cacacaacat acg                                                         973


<210> 22
<211> 294
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Any amino acid

<400> 22
Met Gln Ile Leu Phe Gln Gly Asp Ser His Asn Glu Ile Xaa Ile Xaa 
1               5                   10                  15      


Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala 
            20                  25                  30          


Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        35                  40                  45              


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
    50                  55                  60                  


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
65                  70                  75                  80  


Ser Thr Ile Asp Ala Thr Gly Ser Thr Thr Tyr Tyr Ala Asp Ser Val 
                85                  90                  95      


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
            100                 105                 110         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        115                 120                 125             


Ala Lys Thr Ser Asn Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Thr Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
                165                 170                 175     


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
            180                 185                 190         


Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        195                 200                 205             


Lys Leu Leu Ile Tyr Asp Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
    210                 215                 220                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
225                 230                 235                 240 


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asp 
                245                 250                 255     


Asp Asn Pro Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            260                 265                 270         


Ala Ala Ala His His His His His His Gly Ala Ala Glu Gln Lys Leu 
        275                 280                 285             


Ile Ser Glu Glu Asp Leu 
    290                 


<210> 23
<211> 959
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (20)..(20)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (55)..(55)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (837)..(838)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (875)..(875)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (895)..(895)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (906)..(906)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (922)..(922)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (944)..(944)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (950)..(950)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (954)..(954)
<223> a, c, t, g, unknown or other

<400> 23
ttcagatcct cttctgagan gagtttttgt tctgcggccc cgtgatggtg atgangatgt       60

gcggccgccc gtttgatttc caccttggtc ccttggccga acgtagtagg actagcataa      120

ctctgttgac agtagtaagt tgcaaaatct tcaggttgca gaccgctgat ggtgagagtg      180

aaatctgtcc cagatccact gccactgaac cttgatggga ccccactttg caaagaggat      240

gcaccataga tcaggagctt aggggctttc cctggtttct gctgatacca atttaaatag      300

ctgctaatgc tctgacttgc ccggcaagtg atggtgactc tgtctcctac agatgcagac      360

agggaggatg gagactgggt catctggatg tccgtcgacc cgccaccgcc gctgccacct      420

ccgcctgaac cgcctccacc gctcgagacg gtgaccaggg ttccctggcc ccagtagtca      480

aaagcagtag cagttttcgc acagtaatat acggccgtgt cctcggctct caggctgttc      540

atttgcagat acagcgtgtt cttggaattg tctctggaga tggtgaaccg gcccttcacg      600

gagtctgcgt aacttgtagc atcaccatta gaataaatag atgagaccca ctccagcccc      660

ttccctggag cctggcggac ccagctcatg gcatagctgc taaaggtgaa tccagaggct      720

gcacaggaga gtctcaggga ccccccaggc tgtaccaagc ctcccccaga ctccaacagc      780

tgcacctcgg ccatggccgg ctgggccgcg agtaataaca atccagcggc tgccgtnnca      840

ataggtattt cattatgact gtctccttga aatanaattt gcatgcaagc ttggngtaat      900

catggncata gctgtttcct gngtgaaatt gttatccgct cacnattccn cacnacata       959


<210> 24
<211> 295
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Any amino acid

<400> 24
Met Gln Ile Xaa Phe Gln Gly Asp Ser His Asn Glu Ile Pro Ile Xaa 
1               5                   10                  15      


Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala 
            20                  25                  30          


Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        35                  40                  45              


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
    50                  55                  60                  


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
65                  70                  75                  80  


Ser Ser Ile Tyr Ser Asn Gly Asp Ala Thr Ser Tyr Ala Asp Ser Val 
                85                  90                  95      


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
            100                 105                 110         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        115                 120                 125             


Ala Lys Thr Ala Thr Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Thr Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
                165                 170                 175     


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
            180                 185                 190         


Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        195                 200                 205             


Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
    210                 215                 220                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
225                 230                 235                 240 


Gly Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
                245                 250                 255     


Ala Ser Pro Thr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            260                 265                 270         


Ala Ala Ala His Xaa His His His His Gly Ala Ala Glu Gln Lys Leu 
        275                 280                 285             


Xaa Ser Glu Glu Asp Leu Lys 
    290                 295 


<210> 25
<211> 971
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (33)..(33)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (851)..(851)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (914)..(914)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (938)..(938)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (952)..(952)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (965)..(966)
<223> a, c, t, g, unknown or other

<400> 25
ctatgcgncc ccattcagat cctcttctga gangagtttt tgttctgcgg ccccgtgatg       60

gtgatgatga tgtgcggccg cccgtttgat ttccaccttg gtcccttggc cgaacgtagg      120

aggcgaagtc tgaacctgtt gacagtagta agttgcaaaa tcttcaggtt gcagactgct      180

gatggtgaga gtgaaatctg tcccagatcc actgccactg aaccttgatg ggaccccact      240

ttgcaacagg gatgcacgat agatcaggag cttaggggct ttccctggtt tctgctgata      300

ccaatttaaa tagctgctaa tgctctggct tgcccggcaa gtgatggtga ctctgtctcc      360

tacagatgca gacagggagg atggagactg ggtcatctgg atgtccgtcg acccgccacc      420

gccgctgcca cctccgcctg aaccgcctcc accgctcgag acggtgacca gggttccctg      480

gccccagtag tcaaactgct taccacgttt cgcacagtaa tatacggccg tgtcctcggc      540

tctcaggctg ttcatttgca gatacagcgt gttcttggaa ttgtctctgg agatggtgaa      600

ccggcccttc acggagtctg cgtaatgtgt cacagtacca tccggccaaa tacctgagac      660

ccactccagc cccttccctg gagcctggcg gacccagctc atggcatagc tgctaaaggt      720

gaatccagag gctgcacagg agagtctcag ggacccccca ggctgtacca agcctccccc      780

agactccaac agctgcacct cggccatggc cggctgggcc gcgagtaata acaatccagc      840

ggctgccgta ngcaataggt atttcattat gactgtctcc ttgaaataga atttgcatgc      900

aagcttggcg taancatggt catagctgtt tcctgtgnga aattgttatc cngctcacaa      960

ttccnncaca a                                                           971


<210> 26
<211> 288
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Any amino acid

<400> 26
Met Lys Tyr Leu Leu Xaa Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Gly Ile Trp Pro Asp Gly Thr Val Thr 
65                  70                  75                  80  


His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Arg Gly Lys Gln Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Arg Ala Ser Leu Leu 
        195                 200                 205             


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Val Gln Thr Ser Pro Pro Thr Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Val Glu Ile Lys Arg Ala Ala Ala His His His His His His Gly 
            260                 265                 270         


Ala Ala Glu Gln Lys Leu Xaa Ser Glu Glu Asp Leu Asn Gly Xaa Ala 
        275                 280                 285             


<210> 27
<211> 965
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (7)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (30)..(30)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (67)..(69)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (747)..(747)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (848)..(848)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (855)..(855)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (889)..(889)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (907)..(908)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (918)..(919)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (960)..(960)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (962)..(962)
<223> a, c, t, g, unknown or other

<400> 27
tatgcgnnna ttcngatcct cttctgagan gagtttttgt tctgcggccc cgtgatggtg       60

atgatgnnnt gcggccgccc gtttgatttc caccttggtc ccttggccga acgtattagg      120

acaatcagta gtctgttgac agtagtaagt tgcaaaatct tcaggttgca gactgctgat      180

ggtgagagtg aaatctgtcc cagatccact gccactgaac cttgatggga ccccactttg      240

caaagtggat gcattataga tcaggagctt aggggctttc cctggtttct gctgatacca      300

atttaaatag ctgctaatgc tctgacttgc ccggcaagtg atggtgactc tgtctcctac      360

agatgcagac agggaggatg gagactgggt catctggatg tccgtcgacc cgccaccgcc      420

gctgccacct ccgcctgaac cgcctccacc gctcgagacg gtgaccaggg ttccctggcc      480

ccagtagtca aaattagcac cagatttcgc acagtaatat acggccgtgt cctcggctct      540

caggctgttc atttgcagat acagcgtgtt cttggaattg tctctggaga tggtgaacct      600

gcccttcacg gagtctgcgt aagatgtagc ataaccacta gcagtaatac ctgagaccca      660

ctccagcccc ttccctggag cctggcggac ccagctcatg gcatagctgc taaaggtgaa      720

tccagaggct gcacaggaga gtctcangga ccccccaggc tgtaccaagc ctcccccaga      780

ctccaacagc tgcacctcgg ccatggccgg ctgggccgcg agtaataaca atccagcggc      840

tgccgtangc aatangtatt tcattatgac tgtctccttg aaatagaant ttgcatgcaa      900

gcttggnnta atcatggnna tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattn      960

cncac                                                                  965


<210> 28
<211> 305
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Any amino acid

<400> 28
Met Ile Xaa Pro Ser Leu His Ala Xaa Phe Tyr Phe Lys Glu Thr Val 
1               5                   10                  15      


Ile Met Lys Tyr Xaa Leu Xaa Thr Ala Ala Ala Gly Leu Leu Leu Leu 
            20                  25                  30          


Ala Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu Glu Ser Gly Gly 
        35                  40                  45              


Gly Leu Val Gln Pro Gly Gly Ser Xaa Arg Leu Ser Cys Ala Ala Ser 
    50                  55                  60                  


Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro 
65                  70                  75                  80  


Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Thr Ala Ser Gly Tyr Ala 
                85                  90                  95      


Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
            100                 105                 110         


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
        115                 120                 125             


Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Gly Ala Asn Phe Asp Tyr 
    130                 135                 140                 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Asp Ile Gln Met Thr 
                165                 170                 175     


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
            180                 185                 190         


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
        195                 200                 205             


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asn Ala Ser Thr 
    210                 215                 220                 


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
225                 230                 235                 240 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
                245                 250                 255     


Tyr Tyr Cys Gln Gln Thr Thr Asp Cys Pro Asn Thr Phe Gly Gln Gly 
            260                 265                 270         


Thr Lys Val Glu Ile Lys Arg Ala Ala Ala Xaa His His His His His 
        275                 280                 285             


Gly Ala Ala Glu Gln Lys Leu Xaa Ser Glu Glu Asp Xaa Asn Xaa Arg 
    290                 295                 300                 


Ile 
305 


<210> 29
<211> 963
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (6)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (28)..(28)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (53)..(54)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (62)..(66)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (610)..(610)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (839)..(839)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (841)..(841)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (846)..(847)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (884)..(885)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (904)..(904)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (908)..(908)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (915)..(915)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (927)..(927)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (931)..(931)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (935)..(935)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (952)..(954)
<223> a, c, t, g, unknown or other

<400> 29
gcggcnnntt cngancctct tctgaganga gtttttgttc tgcggccccg tgnnggtgat       60

gnnnnngtgc ggccgcccgt ttgatttcca ccttggtccc ttggccgaac gtattagggg      120

tactgtaact ctgttgacag tagtaagttg caaaatcttc aggttgcaga ctgctgatgg      180

tgagagtgaa atctgtccca gatccactgc cactgaacct tgatgggacc ccactttgca      240

aactggatgc agcatagatc aggagcttag gggctttccc tggtttctgc tgataccaat      300

ttaaatagct gctaatgctc tgacttgccc ggcaagtgat ggtgactctg tctcctacag      360

atgcagacag ggaggatgga gactgggtca tctggatgtc cgtcgacccg ccaccgccgc      420

tgccacctcc gcctgaaccg cctccaccgc tcgagacggt gaccagggtt ccctggcccc      480

agtagtcaaa cgccggatga tatttcgcac agtaatatac ggccgtgtcc tcggctctca      540

ggctgttcat ttgcagatac agcgtgttct tggaattgtc tctggagatg gtgaaccggc      600

ccttcacggn gtctgcgtac tctgtcggca gaccctgcgg cgcaatcgat gagacccact      660

ccagcccctt ccctggagcc tggcggaccc agctcatggc atagctgcta aaggtgaatc      720

cagaggctgc acaggagagt ctcagggacc ccccaggctg taccaagcct cccccagact      780

ccaacagctg cacctcggcc atggccggct gggccgcgag taataacaat ccagcggcng      840

ncgtanncaa taggtatttc attatgactg tctccttgaa atannatttg catgcaagct      900

tggngtantc atggncatag ctgtttnctg ngtgnaaatt gttatccgct cnnnaatttc      960

cac                                                                    963


<210> 30
<211> 283
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (266)..(267)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Any amino acid

<400> 30
Met Lys Tyr Leu Leu Xaa Thr Xaa Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Ser Ile Ala Pro Gln Gly Leu Pro Thr 
65                  70                  75                  80  


Glu Tyr Ala Asp Xaa Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Tyr His Pro Ala Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
        195                 200                 205             


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Asn Thr Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Val Glu Ile Lys Arg Ala Ala Ala Xaa Xaa His His Xaa His Gly 
            260                 265                 270         


Ala Ala Glu Gln Lys Leu Xaa Ser Glu Glu Asp 
        275                 280             


<210> 31
<211> 953
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (4)..(4)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (7)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (63)..(67)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (688)..(688)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (846)..(846)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (853)..(853)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (908)..(908)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (915)..(915)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (924)..(924)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (941)..(941)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (943)..(943)
<223> a, c, t, g, unknown or other

<400> 31
gcgnccnntt cagatcctct tctgagatga gtttttgttc tgcggccccg tgatggtgat       60

gannnnntgc ggccgcccgt ttgatttcca ccttggtccc ttggccgaac gtagaaggag      120

aattaccagt ctgttgacag tagtaagttg caaaatcttc aggttgcaga ctgctgatgg      180

tgagagtgaa atctgtccca gatccactgc cactgaacct tgatgggacc ccactttgca      240

aagcggatgc agtatagatc aggagcttag gggctttccc tggtttctgc tgataccaat      300

ttaaatagct gctaatgctc tgacttgccc ggcaagtgat ggtgactctg tctcctacag      360

atgcagacag ggaggatgga gactgggtca tctggatgtc cgtcgacccg ccaccgccgc      420

tgccacctcc gcctgaaccg cctccaccgc tcgagacggt gaccagggtt ccctggcccc      480

agtagtcaaa agtactataa gatttcgcac agtaatatac ggccgtgtcc tcggctctca      540

ggctgttcat ttgcagatac agcgtgttct tggaattgtc tctggagatg gtgaaccggc      600

ccttcacgga gtctgcgtaa gctgtactag cactactagc agcaatacct gagacccact      660

ccagcccctt ccctggagcc tggcggancc agctcatggc atagctgcta aaggtgaatc      720

cagaggctgc acaggagagt ctcagggacc ccccaggctg taccaagcct cccccggact      780

ccaacagctg cacctcggcc atggccggct gggccgcgag taataacaat ccagcggctg      840

ccgtangcaa tangtatttc attatgactg tctccttgaa atagaatttg catgcaagct      900

tggcgtantc atggncatag ctgnttcctg tgtgaaattg ntnatccgct cac             953


<210> 32
<211> 284
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (266)..(267)
<223> Any amino acid

<400> 32
Met Lys Tyr Xaa Leu Xaa Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Xaa Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Gly Ile Ala Ala Ser Ser Ala Ser Thr 
65                  70                  75                  80  


Ala Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Ser Tyr Ser Thr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Thr Ala Ser Ala Leu 
        195                 200                 205             


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Thr Gly Asn Ser Pro Ser Thr Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Val Glu Ile Lys Arg Ala Ala Ala Xaa Xaa His His His His Gly 
            260                 265                 270         


Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
        275                 280                 


<210> 33
<211> 696
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 33
atggccgagg tgcagctgtc ggagtctggg ggaggcttgg tacagcctgg ggggtccctg       60

agactctcct gtgcagcctc tggattcacc tttagcagct atgccatgag ctgggtccgc      120

caggctccag ggaaggggct ggagtgggtc tcaggtatta atagtaatgg tacttctaca      180

tcttacgcag actccgtgaa gggccggttc accatctcca gagacaattc caagaacacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ccgtatatta ctgtgcgaaa      300

tctgcttctg attttgacta ctggggccag ggaaccctgg tcaccgtctc gagcggtgga      360

ggcggttcag gcggaggtgg cagcggcggt ggcgggtcga cggacatcca gatgacccag      420

tctccatcct ccctgtctgc atctgtagga gacagagtca ccatcacttg ccgggcaagt      480

cagagcatta gcagctattt aaattggtat cagcagaaac cagggaaagc ccctaagctc      540

ctgatctata atgcatccac tttgcaaagt ggggtcccat caaggttcag tggcagtgga      600

tctgggacag atttcactct caccatcagc agtctgcaac ctgaagattt tgcaacttac      660

tactgtcaac agaatactta tagtcctact acgttc                                696


<210> 34
<211> 264
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Met Lys Tyr Leu Leu Pro Thr Asn Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Asn Pro Ala Met Ala Glu Val Gln Leu Ser Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Gly Ile Asn Ser Asn Gly Thr Ser Thr 
65                  70                  75                  80  


Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Ser Ala Ser Asp Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asn Ala Ser Thr Leu 
        195                 200                 205             


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Asn Thr Tyr Ser Pro Thr Thr Phe Gly Asn Asn Asn 
                245                 250                 255     


Lys Val Glu Ile Lys Arg Ala Ala 
            260                 


<210> 35
<211> 732
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (706)..(706)
<223> a, c, t, g, unknown or other

<400> 35
atggccgaga tgcagctgtt ggagtctggg ggaggcttgg tacagcctgg ggggtccctg       60

agactctcct gtgcagcctc tggattcacc tttagcagct atgccatgag ctgggtccgc      120

caggctccag ggaaggggct ggagtgggtc tcatatatta ctgctaatgg tgatagtaca      180

acttacgcag actccgtgaa gggccggttc accatctcca gagacaattc caagaacacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ccgtatatta ctgtgcgaaa      300

agtactactg attttgacta ctggggccag ggaaccctgg tcaccgtctc gagcggtgga      360

ggcggttcag gcggaggtgg cagcggcggt ggcgggtcga cggacatcca gatgacccag      420

tctccatcct ccctgtctgc atctgtagga gacagagtca ccatcacttg ccgggcaagt      480

cagagcatta gcagctattt aaattggtat cagcagaaac cagggaaagc ccctaagctc      540

ctgatctata gtgcatccaa tttgcaaagt ggggtcccat caaggttcag tggcagtgga      600

tctgggacag atttcactct caccatcagc agtctgcaac ctgaagattt tgcaacttac      660

tactgtcaac agacttctta tagtccttct acgttcggcc aagggnccaa ggtggaaatc      720

aaacgggcgg cc                                                          732


<210> 36
<211> 245
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (236)..(236)
<223> Any amino acid

<400> 36
Met Ala Glu Met Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Tyr Ile Thr Ala Asn Gly Asp Ser Thr Thr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Lys Ser Thr Thr Asp Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Thr Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Asn Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Thr Ser Tyr Ser Pro Ser Thr Phe Gly Gln Gly Xaa Lys Val Glu Ile 
225                 230                 235                 240 


Lys Arg Ala Ala Ala 
                245 


<210> 37
<211> 735
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (54)..(54)
<223> a, c, t, g, unknown or other

<400> 37
atggccgagg tgcagctgtt ggagtctggg ggaggcttgg tacagcctgg gggntccctg       60

agactctcct gtgcagcctc tggattcacc tttagcagct atgccatgag ctgggtccgc      120

caggctccag ggaaggggct ggagtgggtc tcaactatta atgctagtgg tggtagtaca      180

ggttacgcag actccgtgaa gggccggttc accatctcca gagacaattc caagaacacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ccgtatatta ctgtgcgaaa      300

gctgatgctt attttgacta ctggggccag ggaaccctgg tcaccgtctc gagcggtgga      360

ggcggttcag gcggaggtgg cagcggcggt ggcgggtcga cggacatcca gatgacccag      420

tctccatcct ccctgtctgc atctgtagga gacagagtca ccatcacttg ccgggcaagt      480

cagagcatta gcagctattt aaattggtat cagcagaaac cagggaaagc ccctaagctc      540

ctgatctatt ctgcatcctc gttgcaaagt ggggtcccat caaggttcag tggcagtgga      600

tctgggacag atttcactct caccatcagc agtctgcaac ctgaagattt tgcaacttac      660

tactgtcaac aggatgctag tggtccttct acgttcggcc aagggaccaa ggtggaaatc      720

aaacgggcgg ccgca                                                       735


<210> 38
<211> 244
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Met Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Thr Ile Asn Ala Ser Gly Gly Ser Thr Gly Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Lys Ala Asp Ala Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Thr Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Asp Ala Ser Gly Pro Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys Arg Ala Ala 
                


<210> 39
<211> 736
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (706)..(706)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (731)..(731)
<223> a, c, t, g, unknown or other

<400> 39
atggccgagg tgcagctgtt ggagtctggg ggaggcttgg tacagcctgg ggggtccctg       60

agactctcct gtgcagcctc tggattcacc tttagcagct atgccatgag ctgggtccgc      120

caggctccag ggaaggggct ggagtgggtc tcatatattg ctgatgatgg tgctaataca      180

gcttacgcag actccgtgaa gggccggttc accatctcca gagacaattc caagaacacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ccgtatatta ctgtgcgaaa      300

aataatgatg gttttgacta ctggggccag ggaaccctgg tcaccgtctc gagcggtgga      360

ggcggttcag gcggaggtgg cagcggcggt ggcgggtcga cgaacatcca gatgacccag      420

tctccatcct ccctgtctgc atctgtagga gacagagtca ccatcacttg ccgggcaagt      480

cagagcatta gcagctattt aaattggtat cagcagaaac cagggaaagc ccctaagctc      540

ctgatctatt ctgcatccac tttgcaaagt ggggtcccat caaggttcag tggcagtgga      600

tctgggacag atttcactct caccatcagc agtctgcaac ctgaagattt tgcaacttac      660

tactgtcaac aggctgctac tagtccttct acgttcggcc aagggnccaa ggtggaaatc      720

aaacgggcgg ncgcac                                                      736


<210> 40
<211> 245
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (236)..(236)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Any amino acid

<400> 40
Met Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Tyr Ile Ala Asp Asp Gly Ala Asn Thr Ala Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Lys Asn Asn Asp Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Thr Asn Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Ala Ala Thr Ser Pro Ser Thr Phe Gly Gln Gly Xaa Lys Val Glu Ile 
225                 230                 235                 240 


Lys Arg Ala Xaa Ala 
                245 


<210> 41
<211> 886
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (27)..(27)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (36)..(36)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (44)..(45)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (76)..(76)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (78)..(78)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (852)..(852)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (875)..(876)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (885)..(885)
<223> a, c, t, g, unknown or other

<400> 41
ttcaaggaga cagtcataat gaaatancct attgcntacg gcanncgctg gattgttatt       60

actcgcggcc cagccngncc atggccgagg tgcagctgtt ggagtctggg ggaggcttgg      120

tacagcctgg ggggtccctg agactctcct gtgcagcctc tggattcacc tttagcagct      180

atgccatgag ctgggtccgc caggctccag ggaaggggct ggagtgggtc tcaaatatta      240

gttctgatgg tgattctaca gcttacgcag actccgtgaa gggccggttc accatctcca      300

gagacaattc caagaacacg ctgtatctgc aaatgaacag cctgagagcc gaggacacgg      360

ccgtatatta ctgtgcgaaa gcttctagta attttgacta ctggggccag ggaaccctgg      420

tcaccgtctc gagcggtgga ggcggttcag gcggaggtgg cagcggcggt ggcgggtcga      480

cggacatcca gatgacccag tctccatcct ccctgtctgc atctgtagga gacagagtca      540

ccatcacttg ccgggcaagt cagagcatta gcagctattt aaattggtat cagcagaaac      600

cagggaaagc ccctaagctc ctgatctatg ctgcatccaa tttgcaaagt ggggtcccat      660

caaggttcag tggcagtgga tctgggacag atttcactct caccatcagc agtctgcaac      720

ctgaagattt tgcaacttac tactgtcaac agtctaattc tgatcctact acgttcggcc      780

aagggaccaa ggtaatcaaa cgggcggccg cacatcatca tcaccatcac ggggccgcag      840

aacaaaaact cntctcagaa gaggatctga atggnnccgc atagnc                     886


<210> 42
<211> 267
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (258)..(258)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (265)..(266)
<223> Any amino acid

<400> 42
Met Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Asn Ile Ser Ser Asp Gly Asp Ser Thr Ala Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Lys Ala Ser Ser Asn Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Thr Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Ser Asn Ser Asp Pro Thr Thr Phe Gly Gln Gly Thr Lys Val Ile Lys 
225                 230                 235                 240 


Arg Ala Ala Ala His His His His His His Gly Ala Ala Glu Gln Lys 
                245                 250                 255     


Leu Xaa Ser Glu Glu Asp Leu Asn Xaa Xaa Ala 
            260                 265         


<210> 43
<211> 909
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (907)..(907)
<223> a, c, t, g, unknown or other

<400> 43
cagggggggc ggngcctatg naaaaaacgc cagcaacgcg gccttttacg gttcctggcc       60

ctttgctggc cttttgctca catgttcttt cctgcgttat cccctgattc tgtggataac      120

cgtattaccg cctttgagtg agctgatacc gctcgccgca gccgaacgac cgagcgcagc      180

gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca aaccgcctct ccccgcgcgt      240

tggccgattc attaatgcag ctggcacgac aggtttcccg actggaaagc gggcagtgag      300

cgcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt acactttatg      360

ctcccggctc gtatgttgtg tggaattgtg agcggataac aatttcacac aggaaacagc      420

tatgaccatg attacgccaa gcttgcatgc aaattctatt tcaaggagac agtcatagct      480

agcatgaaaa agatttggct ggcgctggct ggtttagttt tagcgtttag cgcatcggcg      540

gactacaaag aggcccagcc ggccatggac ctgggtaaga aactgctgga agctgctcgt      600

gctggtcagg acgacgaagt tcgtatcctg atggctaacg gtgctgacgt taacgctcat      660

gacgaacagg gtactactcc gctgcacctg gctgctaaag aaggtcacct ggaaatcgtt      720

gaagttctgc tgaagtacgg tgctgacgtt aacgctcagg acaaattcgg taagaccgct      780

ttcgacatct ccatcgacaa cggtaacgag gacctggctg aaatcctgca agcggccgca      840

catcatcatc accatcacgg ggccgcagaa caaaaactca tctcagaaga ggatctgaat      900

ggccgcnta                                                              909


<210> 44
<211> 183
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (183)..(183)
<223> Any amino acid

<400> 44
Met Leu Pro Ala Arg Met Leu Cys Gly Ile Val Ser Gly Gln Phe His 
1               5                   10                  15      


Thr Gly Asn Ser Tyr Asp His Asp Tyr Ala Lys Leu Ala Cys Lys Phe 
            20                  25                  30          


Tyr Phe Lys Glu Thr Val Ile Ala Ser Met Lys Lys Ile Trp Leu Ala 
        35                  40                  45              


Leu Ala Gly Leu Val Leu Ala Phe Ser Ala Ser Ala Asp Tyr Lys Glu 
    50                  55                  60                  


Ala Gln Pro Ala Met Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg 
65                  70                  75                  80  


Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp 
                85                  90                  95      


Val Asn Ala His Asp Glu Gln Gly Thr Thr Pro Leu His Leu Ala Ala 
            100                 105                 110         


Lys Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala 
        115                 120                 125             


Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser 
    130                 135                 140                 


Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ala Ala Ala 
145                 150                 155                 160 


His His His His His His Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu 
                165                 170                 175     


Glu Asp Leu Asn Gly Arg Xaa 
            180             


<210> 45
<211> 930
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (12)..(17)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (30)..(30)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (64)..(64)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (98)..(99)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (101)..(101)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (139)..(140)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (898)..(898)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (914)..(914)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (918)..(922)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (926)..(926)
<223> a, c, t, g, unknown or other

<400> 45
gagctatgag annnnnncca cgcttccccn aagggagaaa ggcggacagg tatcccggta       60

agcnggcagg gtcggaacag gagagcgcac gagggagnnt ncagggggaa acgcctggta      120

tctttatagt cctgtcggnn tttcgccacc tctgacttga gcgtcgattt tttgtgatgc      180

tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg      240

gccttttgct ggccttttgc tcacatgttc tttcctgcgt tatcccctga ttctgtggat      300

aaccgtatta ccgcctttga gtgagctgat accgctcgcc gcagccgaac gaccgagcgc      360

agcgagtcag tgagcgagga agcggaagag cgcccaatac gcaaaccgcc tctccccgcg      420

cgttggccga ttcattaatg cagctggcac gacaggtttc ccgactggaa agcgggcagt      480

gagcgcaacg caattaatgt gagttagctc actcattagg caccccaggc tttacacttt      540

atgctcccgg ctcgtatgtt gtgtggaatt gtgagcggat aacaatttca cacaggaaac      600

agctatgacc atgattacgc caagcttgca tgcaaattct atttcaagga gacagtcata      660

gctagcatga aaaagatttg gctggcgctg gctggtttag ttttagcgtt tagcgcatcg      720

gcggactaca aagaggccca gccggccatg gtaggaagac ctgacgttaa cgctcaggac      780

aaattcggta agaccgcttt cgacatctcc atcgacaacg gtaacgagga cctggctgaa      840

atcctgcaag cggccgcaca tcatcatcac catcacgggg ccgcagaaca aaaactcntc      900

tcagaagagg atcngaannn nncgcntaga                                       930


<210> 46
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (207)..(207)
<223> Any amino acid

<400> 46
Met Phe Phe Pro Ala Leu Ser Pro Asp Ser Val Asp Asn Arg Ile Thr 
1               5                   10                  15      


Ala Phe Glu Ala Asp Thr Ala Arg Arg Ser Arg Thr Thr Glu Arg Ser 
            20                  25                  30          


Glu Ser Val Ser Glu Glu Ala Glu Glu Arg Pro Ile Arg Lys Pro Pro 
        35                  40                  45              


Leu Pro Ala Arg Trp Pro Ile His Cys Ser Trp His Asp Arg Phe Pro 
    50                  55                  60                  


Asp Trp Lys Ala Gly Ser Glu Arg Asn Ala Ile Asn Val Ser Leu Thr 
65                  70                  75                  80  


His Ala Pro Gln Ala Leu His Phe Met Leu Pro Ala Arg Met Leu Cys 
                85                  90                  95      


Gly Ile Val Ser Gly Gln Phe His Thr Gly Asn Ser Tyr Asp His Asp 
            100                 105                 110         


Tyr Ala Lys Leu Ala Cys Lys Phe Tyr Phe Lys Glu Thr Val Ile Ala 
        115                 120                 125             


Ser Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe 
    130                 135                 140                 


Ser Ala Ser Ala Asp Tyr Lys Glu Ala Gln Pro Ala Met Val Gly Arg 
145                 150                 155                 160 


Pro Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile 
                165                 170                 175     


Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ala Ala 
            180                 185                 190         


Ala His His His His His His Gly Ala Ala Glu Gln Lys Leu Xaa Ser 
        195                 200                 205             


Glu Glu Asp 
    210     


<210> 47
<211> 915
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (35)..(36)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (44)..(44)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (46)..(46)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (48)..(48)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (58)..(61)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (77)..(77)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (104)..(105)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (124)..(124)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (141)..(141)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (158)..(158)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (901)..(902)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (906)..(906)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (908)..(910)
<223> a, c, t, g, unknown or other

<400> 47
tcgtcagggg ggncggnagc ctatggaaaa aacgnnagca acgngncntt tttacggnnn       60

ntggcctttt gctggcnttt gctcacatgt tctttcctgc gttnncccct gattctgtgg      120

atanccgtat taccgccttt ngagtgagct gataccgntc gccgcagccg aacgaccgag      180

cgcagcgagt cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc      240

gcgcgttggc cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc      300

agtgagcgca acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac      360

tttatgctcc cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga      420

aacagctatg accatgatta cgccaagctt gcatgcaaat tctatttcaa ggagacagtc      480

atagctagca tgaaaaagat ttggctggcg ctggctggtt tagttttagc gtttagcgca      540

tcggcggact acaaagaggc ccagccggcc atggacctgg gtaagaaact gctggaagct      600

gctcgtgctg gtcaggacga cgaagttcgt atcctgatgg ctaacggtgc tgacgttaac      660

gcttgggaca tgactggtca tactccgctg cacctggctg ctcagttcgg tcacctggaa      720

atcgttgaag ttctgctgaa gcacggtgct gacgttaacg ctcaggacaa attcggtaag      780

accgctttcg acatctccat cgacaacggt aacgaggacc tggctgaaat cctgcaagcg      840

gccgcacatc atcatcacca tcacggggcc gcagaacaaa aactcatctc agaagaggat      900

nngaangnnn ccgca                                                       915


<210> 48
<211> 178
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 48
Met Leu Pro Ala Arg Met Leu Cys Gly Ile Val Ser Gly Gln Phe His 
1               5                   10                  15      


Thr Gly Asn Ser Tyr Asp His Asp Tyr Ala Lys Leu Ala Cys Lys Phe 
            20                  25                  30          


Tyr Phe Lys Glu Thr Val Ile Ala Ser Met Lys Lys Ile Trp Leu Ala 
        35                  40                  45              


Leu Ala Gly Leu Val Leu Ala Phe Ser Ala Ser Ala Asp Tyr Lys Glu 
    50                  55                  60                  


Ala Gln Pro Ala Met Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg 
65                  70                  75                  80  


Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp 
                85                  90                  95      


Val Asn Ala Trp Asp Met Thr Gly His Thr Pro Leu His Leu Ala Ala 
            100                 105                 110         


Gln Phe Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala 
        115                 120                 125             


Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser 
    130                 135                 140                 


Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ala Ala Ala 
145                 150                 155                 160 


His His His His His His Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu 
                165                 170                 175     


Glu Asp 
        


<210> 49
<211> 848
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (23)..(23)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (28)..(28)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (30)..(30)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (35)..(35)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (41)..(41)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (47)..(47)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (51)..(54)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (60)..(61)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (89)..(89)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (100)..(100)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (102)..(102)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (106)..(106)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (108)..(108)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (114)..(115)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (118)..(118)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (120)..(120)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (152)..(152)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (164)..(164)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (170)..(170)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (179)..(179)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (221)..(222)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (240)..(240)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (292)..(292)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (337)..(339)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (480)..(480)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (603)..(603)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (645)..(645)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (707)..(707)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (719)..(719)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (753)..(753)
<223> a, c, t, g, unknown or other

<400> 49
tttatagtnc ntgtcgggtt tcnccacntn tgacntgagc ntcgatnttt nnnntgctcn       60

ncaggggggc ggagcctatg gaaaaacgnc agcaacgcgn cntttntncg gttnntgncn      120

ttttgctggc cttttgctca catgttcttt cntgcgttat cccntgattn tgtggatanc      180

cgtattaccg cctttgagtg agctgatacc gctcgccgca nncgaacgac cgagcgcagn      240

gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca aaccgcctct cnccgcgcgt      300

tggccgattc attaatgcag ctggcacgac aggtttnnng actggaaagc gggcagtgag      360

cgcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt acactttatg      420

ctcccggctc gtatgttgtg tggaattgtg agcggataac aatttcacac aggaaacagn      480

tatgaccatg attacgccaa gcttgcatgc aaattctatt tcaaggagac agtcatagct      540

agcatgaaaa agatttggct ggcgctggct ggtttagttt tagcgtttag cgcatcggcg      600

gantacaaag aggcccagcc ggccatgggc ggaaccagca gtttnttacc caggtccatg      660

gacctgggtc acctggaaat cgttgaagtt ctgctgaagt acggtgntga cgttaacgnt      720

caggacaaat tcggtaagac cgctttcgac atntccatcg acaacggtaa cgaggacctg      780

gctgaaatcc tgcaagcggc cgcacatcat catcaccatc atcgggctcg cagaacaaaa      840

atcatctc                                                               848


<210> 50
<211> 230
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Any amino acid

<400> 50
Met Phe Phe Xaa Ala Leu Ser Xaa Asp Xaa Val Asp Xaa Arg Ile Thr 
1               5                   10                  15      


Ala Phe Glu Ala Asp Thr Ala Arg Arg Xaa Arg Thr Thr Glu Arg Xaa 
            20                  25                  30          


Glu Ser Val Ser Glu Glu Ala Glu Glu Arg Pro Ile Arg Lys Pro Pro 
        35                  40                  45              


Leu Xaa Ala Arg Trp Pro Ile His Cys Ser Trp His Asp Arg Phe Xaa 
    50                  55                  60                  


Asp Trp Lys Ala Gly Ser Glu Arg Asn Ala Ile Asn Val Ser Leu Thr 
65                  70                  75                  80  


His Ala Pro Gln Ala Leu His Phe Met Leu Pro Ala Arg Met Leu Cys 
                85                  90                  95      


Gly Ile Val Ser Gly Gln Phe His Thr Gly Asn Xaa Tyr Asp His Asp 
            100                 105                 110         


Tyr Ala Lys Leu Ala Cys Lys Phe Tyr Phe Lys Glu Thr Val Ile Ala 
        115                 120                 125             


Ser Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe 
    130                 135                 140                 


Ser Ala Ser Ala Xaa Tyr Lys Glu Ala Gln Pro Ala Met Gly Gly Thr 
145                 150                 155                 160 


Ser Ser Xaa Leu Pro Arg Ser Met Asp Leu Gly His Leu Glu Ile Val 
                165                 170                 175     


Glu Val Leu Leu Lys Tyr Gly Xaa Asp Val Asn Xaa Gln Asp Lys Phe 
            180                 185                 190         


Gly Lys Thr Ala Phe Asp Xaa Ser Ile Asp Asn Gly Asn Glu Asp Leu 
        195                 200                 205             


Ala Glu Ile Leu Gln Ala Ala Ala His His His His His His Arg Ala 
    210                 215                 220                 


Arg Arg Thr Lys Ile Ile 
225                 230 


<210> 51
<211> 900
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (33)..(33)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (59)..(59)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (61)..(61)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (63)..(63)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (69)..(69)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (133)..(136)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (833)..(838)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (872)..(874)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (886)..(887)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (891)..(894)
<223> a, c, t, g, unknown or other

<400> 51
gagcctatgg aaaaaacgcc cagcaacgcg gcntttttac ggttcctggc cttttgctng       60

ncnttttgnt cacatgttct ttcctgcgtt atcccctgat tctgtggata accgtattac      120

cgcctttgag tgnnnngata ccgctcgccg cagccgaacg accgagcgca gcgagtcagt      180

gagcgaggaa gcggaagagc gcccaatacg caaaccgcct ctccccgcgc gttggccgat      240

tcattaatgc agctggcacg acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc      300

aattaatgtg agttagctca ctcattaggc accccaggct ttacacttta tgctcccggc      360

tcgtatgttg tgtggaattg tgagcggata acaatttcac acaggaaaca gctatgacca      420

tgattacgcc aagcttgcat gcaaattcta tttcaaggag acagtcatag ctagcatgaa      480

aaagatttgg ctggcgctgg ctggtttagt tttagcgttt agcgcatcgg cggactacaa      540

agaggcccag ccggccatgg acctgggtaa gaaactgctg gaagctgctc gtgctggtca      600

ggacgacgaa gttcgtatcc tgatggctaa cggtgctgac gttaacgctg acgacttctc      660

tggtactact ccgctgcacc tggctgctca tcatggtcac ctggaaatcg ttgaagttct      720

gctgaagtac ggtgctgacg ttaacgctca ggacaaattc ggtaagaccg ctttcgacat      780

ctccatcgac aacggtaacg aggacctggc tgaaatcctg caagcggccg cannnnnnca      840

tcaccatcac ggggccgcag aacaaaaact cnnncagaag aggatnngaa nnnncgcata      900


<210> 52
<211> 263
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (20)..(21)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (250)..(251)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Any amino acid

<400> 52
Met Phe Phe Pro Ala Leu Ser Pro Asp Ser Val Asp Asn Arg Ile Thr 
1               5                   10                  15      


Ala Phe Glu Xaa Xaa Asp Thr Ala Arg Arg Ser Arg Thr Thr Glu Arg 
            20                  25                  30          


Ser Glu Ser Val Ser Glu Glu Ala Glu Glu Arg Pro Ile Arg Lys Pro 
        35                  40                  45              


Pro Leu Pro Ala Arg Trp Pro Ile His Cys Ser Trp His Asp Arg Phe 
    50                  55                  60                  


Pro Asp Trp Lys Ala Gly Ser Glu Arg Asn Ala Ile Asn Val Ser Leu 
65                  70                  75                  80  


Thr His Ala Pro Gln Ala Leu His Phe Met Leu Pro Ala Arg Met Leu 
                85                  90                  95      


Cys Gly Ile Val Ser Gly Gln Phe His Thr Gly Asn Ser Tyr Asp His 
            100                 105                 110         


Asp Tyr Ala Lys Leu Ala Cys Lys Phe Tyr Phe Lys Glu Thr Val Ile 
        115                 120                 125             


Ala Ser Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala 
    130                 135                 140                 


Phe Ser Ala Ser Ala Asp Tyr Lys Glu Ala Gln Pro Ala Met Asp Leu 
145                 150                 155                 160 


Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val 
                165                 170                 175     


Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Asp Asp Phe Ser 
            180                 185                 190         


Gly Thr Thr Pro Leu His Leu Ala Ala His His Gly His Leu Glu Ile 
        195                 200                 205             


Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Gln Asp Lys 
    210                 215                 220                 


Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp 
225                 230                 235                 240 


Leu Ala Glu Ile Leu Gln Ala Ala Ala Xaa Xaa His His His His Gly 
                245                 250                 255     


Ala Ala Glu Gln Lys Leu Xaa 
            260             


<210> 53
<211> 919
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (3)..(3)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (5)..(5)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (29)..(29)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (52)..(52)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (130)..(130)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (910)..(912)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (916)..(916)
<223> a, c, t, g, unknown or other

<400> 53
gangntcnnc agggggggcg gagcctatng aaaaaacgcc agcaacgcgg cnttttttac       60

ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta tcccctgatt      120

ctgtggatan ccgtattacc gcctttgagt gagctgatac cgctcgccgc agccgaacga      180

ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cccaatacgc aaaccgcctc      240

tccccgcgcg ttggccgatt cattaatgca gctggcacga caggtttccc gactggaaag      300

cgggcagtga gcgcaacgca attaatgtga gttagctcac tcattaggca ccccaggctt      360

tacactttat gctcccggct cgtatgttgt gtggaattgt gagcggataa caatttcaca      420

caggaaacag ctatgaccat gattacgcca agcttgcatg caaattctat ttcaaggaga      480

cagtcatagc tagcatgaaa aagatttggc tggcgctggc tggtttagtt ttagcgttta      540

gcgcatcggc ggactacaaa gaggcccagc cggccatgga cctgggtaag aaactgctgg      600

aagctgctcg tgctggtcag gacgacgaag ttcgtatcct gatggctaac ggtgctgacg      660

ttaacgctct ggacgaagtt ggttctactc cgctgcacct ggctgctatg gctggtcacc      720

tggaaatcgt tgaagtgctg aagcacggtg ctgacgttaa cgctcaggac aaattcggta      780

agaccgcttt cgacatctcc atcgacaacg gtaacgagga cctggctgaa atcctgcaag      840

cggccgcaca tcatcatcac catcacgggg ccgcagaaca aaaactcatc tcagaagagg      900

atctgaatgn nncgcntag                                                   919


<210> 54
<211> 177
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 54
Met Leu Pro Ala Arg Met Leu Cys Gly Ile Val Ser Gly Gln Phe His 
1               5                   10                  15      


Thr Gly Asn Ser Tyr Asp His Asp Tyr Ala Lys Leu Ala Cys Lys Phe 
            20                  25                  30          


Tyr Phe Lys Glu Thr Val Ile Ala Ser Met Lys Lys Ile Trp Leu Ala 
        35                  40                  45              


Leu Ala Gly Leu Val Leu Ala Phe Ser Ala Ser Ala Asp Tyr Lys Glu 
    50                  55                  60                  


Ala Gln Pro Ala Met Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg 
65                  70                  75                  80  


Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp 
                85                  90                  95      


Val Asn Ala Leu Asp Glu Val Gly Ser Thr Pro Leu His Leu Ala Ala 
            100                 105                 110         


Met Ala Gly His Leu Glu Ile Val Glu Val Leu Lys His Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ala Ala Ala His 
145                 150                 155                 160 


His His His His His Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu 
                165                 170                 175     


Asp 
    


<210> 55
<211> 934
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (34)..(34)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (37)..(38)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (58)..(59)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (97)..(97)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (923)..(927)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (931)..(931)
<223> a, c, t, g, unknown or other

<400> 55
ggacaggnta tccggtaaag cggcagggtc ggancannag agcgcacgag ggagcttnnc       60

agggggaaac gcctggtatc tttatagtcc tgtcggnttt cgcccacctc tgacttgagc      120

gtcgattttt gtgatgctcg tcaggggggg cggagcctat ggaaaaacgc cagcaacgcg      180

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta      240

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc      300

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cccaatacgc      360

aaaccgcctc tccccgcgcg ttggccgatt cattaatgca gctggcacga caggtttccc      420

gactggaaag cgggcagtga gcgcaacgca attaatgtga gttagctcac tcattaggca      480

ccccaggctt tacactttat gctcccggct cgtatgttgt gtggaattgt gagcggataa      540

caatttcaca caggaaacag ctatgaccat gattacgcca agcttgcatg caaattctat      600

ttcaaggaga cagtcatagc tagcatgaaa aagatttggc tggcgctggc tggtttagtt      660

ttagcgttta gcgcatcggc ggactacaaa gaggcccagc cggccatgga cctggctgct      720

catgttggtc acctggaaat cgttgaagtt ctgctgaagt acggtgctga cgttaacgct      780

caggacaaat tcggtaagac cgctttcgac atctccatcg acaacggtaa cgaggacctg      840

gctgaaatcc tgcaagcggc cgcacatcat catcaccatc acggggccgc agaacaaaaa      900

ctcatctcag aagaggatct gannnnncgc ntag                                  934


<210> 56
<211> 228
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 56
Met Phe Phe Pro Ala Leu Ser Pro Asp Ser Val Asp Asn Arg Ile Thr 
1               5                   10                  15      


Ala Phe Glu Ala Asp Thr Ala Arg Arg Ser Arg Thr Thr Glu Arg Ser 
            20                  25                  30          


Glu Ser Val Ser Glu Glu Ala Glu Glu Arg Pro Ile Arg Lys Pro Pro 
        35                  40                  45              


Leu Pro Ala Arg Trp Pro Ile His Cys Ser Trp His Asp Arg Phe Pro 
    50                  55                  60                  


Asp Trp Lys Ala Gly Ser Glu Arg Asn Ala Ile Asn Val Ser Leu Thr 
65                  70                  75                  80  


His Ala Pro Gln Ala Leu His Phe Met Leu Pro Ala Arg Met Leu Cys 
                85                  90                  95      


Gly Ile Val Ser Gly Gln Phe His Thr Gly Asn Ser Tyr Asp His Asp 
            100                 105                 110         


Tyr Ala Lys Leu Ala Cys Lys Phe Tyr Phe Lys Glu Thr Val Ile Ala 
        115                 120                 125             


Ser Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe 
    130                 135                 140                 


Ser Ala Ser Ala Asp Tyr Lys Glu Ala Gln Pro Ala Met Asp Leu Ala 
145                 150                 155                 160 


Ala His Val Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly 
                165                 170                 175     


Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile 
            180                 185                 190         


Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ala Ala 
        195                 200                 205             


Ala His His His His His His Gly Ala Ala Glu Gln Lys Leu Ile Ser 
    210                 215                 220                 


Glu Glu Asp Leu 
225             


<210> 57
<211> 201
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(100)
<223> This region may encompass 3-100 residues

<220>
<221> MISC_FEATURE
<222> (102)..(201)
<223> This region may encompass 3-100 residues

<400> 57
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    50                  55                  60                  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
                85                  90                  95      


Gly Gly Gly Gly Pro Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            100                 105                 110         


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
        115                 120                 125             


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    130                 135                 140                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
145                 150                 155                 160 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
                165                 170                 175     


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            180                 185                 190         


Gly Gly Gly Gly Gly Gly Gly Gly Gly 
        195                 200     


