                         SEQUENCE LISTING

<110>  Los Angeles Biomedical Research Institute at Harbor-UCLA 
       Medical Center
 
<120>  Synthetic Lung Surfactant With Enhanced Stability And 
       Effectiveness

<130>  0WVR-225782-WO

<140>  PCT/US2016/067317
<141>  2016-12-16

<150>  62/268,800
<151>  2015-12-17

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  1

Xaa Trp Leu Xaa Arg Ala Leu Ile Lys Arg Ile Gln Ala Glx Ile 
1               5                   10                  15  


<210>  2
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<400>  2

Arg Glx Leu Pro Gln Leu Val Xaa Arg Leu Val Leu Arg Xaa Ser 
1               5                   10                  15  


<210>  3
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Pro Lys Gly Gly 
1               


<210>  4
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Asp Ala Thr Lys 
1               


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Phe Pro Ile Pro Leu Pro Tyr 
1               5           


<210>  6
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Phe Pro Ile Pro Leu Pro Tyr Cys Trp Leu Cys Arg Ala Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Met Ile Pro Lys Gly Ala Leu Ala Val Ala Val Ala 
            20                  25                  30          


Gln Val Cys Arg Val Val Pro Leu Val Ala Gly Gly Ile Cys Gln Cys 
        35                  40                  45              


Leu Ala Glu Arg Tyr Ser Val Ile Leu Leu Asp Thr Leu Leu Gly Arg 
    50                  55                  60                  


Met Leu Pro Gln Leu Val Cys Arg Leu Val Leu Arg Cys Ser 
65                  70                  75              


<210>  7
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Phe Pro Ile Pro Leu Pro Tyr Cys Trp Leu Cys Arg Ala Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Met Ile Pro Lys Gly Gly Arg Met Leu Pro Gln Leu 
            20                  25                  30          


Val Cys Arg Leu Val Leu Arg Cys Ser 
        35                  40      


<210>  8
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Phe Pro Ile Pro Leu Pro Tyr Cys Trp Leu Cys Arg Ala Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Met Ile Asp Ala Thr Lys Arg Met Leu Pro Gln Leu 
            20                  25                  30          


Val Cys Arg Leu Val Leu Arg Cys Ser 
        35                  40      


<210>  9
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Cys Trp Leu Cys Arg Ala Leu Ile Lys Arg Ile Gln Ala Met Ile Pro 
1               5                   10                  15      


Lys Gly Gly Arg Met Leu Pro Gln Leu Val Cys Arg Leu Val Leu Arg 
            20                  25                  30          


Cys Ser 
        


<210>  10
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Cys Trp Leu Cys Arg Ala Leu Ile Lys Arg Ile Gln Ala Met Ile Asp 
1               5                   10                  15      


Ala Thr Lys Arg Met Leu Pro Gln Leu Val Cys Arg Leu Val Leu Arg 
            20                  25                  30          


Cys Ser 
        


<210>  11
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Tyr Trp Leu Tyr Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Leu Trp Leu Tyr Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Ala Trp Leu Tyr Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Phe Trp Leu Tyr Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile 
1               5                   10                  15  


<210>  15
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Tyr Trp Leu Phe Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Leu Trp Leu Phe Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile 
1               5                   10                  15  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Ala Trp Leu Phe Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Phe Trp Leu Phe Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Arg Leu Leu Pro Gln Leu Val Tyr Arg Leu Val Leu Arg Tyr Ser 
1               5                   10                  15  


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Arg Leu Leu Pro Gln Leu Val Tyr Arg Leu Val Leu Arg Leu Ser 
1               5                   10                  15  


<210>  21
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Arg Leu Leu Pro Gln Leu Val Tyr Arg Leu Val Leu Arg Ala Ser 
1               5                   10                  15  


<210>  22
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Arg Leu Leu Pro Gln Leu Val Tyr Arg Leu Val Leu Arg Phe Ser 
1               5                   10                  15  


<210>  23
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Arg Leu Leu Pro Gln Leu Val Phe Arg Leu Val Leu Arg Tyr Ser 
1               5                   10                  15  


<210>  24
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Arg Leu Leu Pro Gln Leu Val Phe Arg Leu Val Leu Arg Leu Ser 
1               5                   10                  15  


<210>  25
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Arg Leu Leu Pro Gln Leu Val Phe Arg Leu Val Leu Arg Ala Ser 
1               5                   10                  15  


<210>  26
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Arg Leu Leu Pro Gln Leu Val Phe Arg Leu Val Leu Arg Phe Ser 
1               5                   10                  15  


<210>  27
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Phe Pro Ile Pro Leu Pro Tyr Tyr Trp Leu Tyr Arg Ala Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Leu Ile Pro Lys Gly Gly Arg Leu Leu Pro Gln Leu 
            20                  25                  30          


Val Tyr Arg Leu Val Leu Arg Tyr Ser 
        35                  40      


<210>  28
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Phe Pro Ile Pro Leu Pro Tyr Leu Trp Leu Tyr Arg Ala Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Leu Ile Pro Lys Gly Gly Arg Leu Leu Pro Gln Leu 
            20                  25                  30          


Val Tyr Arg Leu Val Leu Arg Leu Ser 
        35                  40      


<210>  29
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29

Phe Pro Ile Pro Leu Pro Tyr Ala Trp Leu Tyr Arg Ala Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Leu Ile Pro Lys Gly Gly Arg Leu Leu Pro Gln Leu 
            20                  25                  30          


Val Tyr Arg Leu Val Leu Arg Ala Ser 
        35                  40      


<210>  30
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30

Phe Pro Ile Pro Leu Pro Tyr Phe Trp Leu Phe Arg Ala Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Leu Ile Pro Lys Gly Gly Arg Leu Leu Pro Gln Leu 
            20                  25                  30          


Val Phe Arg Leu Val Leu Arg Phe Ser 
        35                  40      


<210>  31
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31

Phe Pro Ile Pro Leu Pro Tyr Leu Trp Leu Phe Arg Ala Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Leu Ile Pro Lys Gly Gly Arg Leu Leu Pro Gln Leu 
            20                  25                  30          


Val Phe Arg Leu Val Leu Arg Leu Ser 
        35                  40      


<210>  32
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32

Phe Pro Ile Pro Leu Pro Tyr Ala Trp Leu Phe Arg Ala Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Leu Ile Pro Lys Gly Gly Arg Leu Leu Pro Gln Leu 
            20                  25                  30          


Val Phe Arg Leu Val Leu Arg Ala Ser 
        35                  40      


<210>  33
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33

Phe Pro Ile Pro Leu Pro Tyr Tyr Trp Leu Phe Arg Ala Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Leu Ile Pro Lys Gly Gly Arg Leu Leu Pro Gln Leu 
            20                  25                  30          


Val Phe Arg Leu Val Leu Arg Tyr Ser 
        35                  40      


<210>  34
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34

Phe Pro Ile Pro Leu Pro Tyr Phe Trp Leu Tyr Arg Ala Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Leu Ile Pro Lys Gly Gly Arg Leu Leu Pro Gln Leu 
            20                  25                  30          


Val Tyr Arg Leu Val Leu Arg Phe Ser 
        35                  40      


<210>  35
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35

Phe Pro Ile Pro Leu Pro Tyr Tyr Trp Leu Tyr Arg Ala Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Leu Ile Asp Ala Thr Lys Arg Leu Leu Pro Gln Leu 
            20                  25                  30          


Val Tyr Arg Leu Val Leu Arg Tyr Ser 
        35                  40      


<210>  36
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36

Phe Pro Ile Pro Leu Pro Tyr Leu Trp Leu Tyr Arg Ala Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Leu Ile Asp Ala Thr Lys Arg Leu Leu Pro Gln Leu 
            20                  25                  30          


Val Tyr Arg Leu Val Leu Arg Leu Ser 
        35                  40      


<210>  37
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37

Phe Pro Ile Pro Leu Pro Tyr Ala Trp Leu Tyr Arg Ala Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Leu Ile Asp Ala Thr Lys Arg Leu Leu Pro Gln Leu 
            20                  25                  30          


Val Tyr Arg Leu Val Leu Arg Ala Ser 
        35                  40      


<210>  38
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38

Phe Pro Ile Pro Leu Pro Tyr Phe Trp Leu Phe Arg Ala Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Leu Ile Asp Ala Thr Lys Arg Leu Leu Pro Gln Leu 
            20                  25                  30          


Val Phe Arg Leu Val Leu Arg Phe Ser 
        35                  40      


<210>  39
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39

Phe Pro Ile Pro Leu Pro Tyr Leu Trp Leu Phe Arg Ala Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Leu Ile Asp Ala Thr Lys Arg Leu Leu Pro Gln Leu 
            20                  25                  30          


Val Phe Arg Leu Val Leu Arg Leu Ser 
        35                  40      


<210>  40
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Phe Pro Ile Pro Leu Pro Tyr Ala Trp Leu Phe Arg Ala Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Leu Ile Asp Ala Thr Lys Arg Leu Leu Pro Gln Leu 
            20                  25                  30          


Val Phe Arg Leu Val Leu Arg Ala Ser 
        35                  40      


<210>  41
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41

Phe Pro Ile Pro Leu Pro Tyr Tyr Trp Leu Phe Arg Ala Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Leu Ile Asp Ala Thr Lys Arg Leu Leu Pro Gln Leu 
            20                  25                  30          


Val Phe Arg Leu Val Leu Arg Tyr Ser 
        35                  40      


<210>  42
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42

Phe Pro Ile Pro Leu Pro Tyr Phe Trp Leu Tyr Arg Ala Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Leu Ile Asp Ala Thr Lys Arg Leu Leu Pro Gln Leu 
            20                  25                  30          


Val Tyr Arg Leu Val Leu Arg Phe Ser 
        35                  40      


<210>  43
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43

Tyr Trp Leu Tyr Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile Pro 
1               5                   10                  15      


Lys Gly Gly Arg Leu Leu Pro Gln Leu Val Tyr Arg Leu Val Leu Arg 
            20                  25                  30          


Tyr Ser 
        


<210>  44
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Leu Trp Leu Tyr Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile Pro 
1               5                   10                  15      


Lys Gly Gly Arg Leu Leu Pro Gln Leu Val Tyr Arg Leu Val Leu Arg 
            20                  25                  30          


Leu Ser 
        


<210>  45
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45

Ala Trp Leu Tyr Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile Pro 
1               5                   10                  15      


Lys Gly Gly Arg Leu Leu Pro Gln Leu Val Tyr Arg Leu Val Leu Arg 
            20                  25                  30          


Ala Ser 
        


<210>  46
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46

Phe Trp Leu Phe Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile Pro 
1               5                   10                  15      


Lys Gly Gly Arg Leu Leu Pro Gln Leu Val Phe Arg Leu Val Leu Arg 
            20                  25                  30          


Phe Ser 
        


<210>  47
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47

Leu Trp Leu Phe Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile Pro 
1               5                   10                  15      


Lys Gly Gly Arg Leu Leu Pro Gln Leu Val Phe Arg Leu Val Leu Arg 
            20                  25                  30          


Leu Ser 
        


<210>  48
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48

Ala Trp Leu Phe Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile Pro 
1               5                   10                  15      


Lys Gly Gly Arg Leu Leu Pro Gln Leu Val Phe Arg Leu Val Leu Arg 
            20                  25                  30          


Ala Ser 
        


<210>  49
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49

Tyr Trp Leu Phe Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile Pro 
1               5                   10                  15      


Lys Gly Gly Arg Leu Leu Pro Gln Leu Val Phe Arg Leu Val Leu Arg 
            20                  25                  30          


Tyr Ser 
        


<210>  50
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50

Phe Trp Leu Tyr Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile Pro 
1               5                   10                  15      


Lys Gly Gly Arg Leu Leu Pro Gln Leu Val Tyr Arg Leu Val Leu Arg 
            20                  25                  30          


Phe Ser 
        


<210>  51
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51

Tyr Trp Leu Tyr Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile Asp 
1               5                   10                  15      


Ala Thr Lys Arg Leu Leu Pro Gln Leu Val Tyr Arg Leu Val Leu Arg 
            20                  25                  30          


Tyr Ser 
        


<210>  52
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52

Leu Trp Leu Tyr Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile Asp 
1               5                   10                  15      


Ala Thr Lys Arg Leu Leu Pro Gln Leu Val Tyr Arg Leu Val Leu Arg 
            20                  25                  30          


Leu Ser 
        


<210>  53
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53

Ala Trp Leu Tyr Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile Asp 
1               5                   10                  15      


Ala Thr Lys Arg Leu Leu Pro Gln Leu Val Tyr Arg Leu Val Leu Arg 
            20                  25                  30          


Ala Ser 
        


<210>  54
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54

Phe Trp Leu Phe Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile Asp 
1               5                   10                  15      


Ala Thr Lys Arg Leu Leu Pro Gln Leu Val Phe Arg Leu Val Leu Arg 
            20                  25                  30          


Phe Ser 
        


<210>  55
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55

Leu Trp Leu Phe Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile Asp 
1               5                   10                  15      


Ala Thr Lys Arg Leu Leu Pro Gln Leu Val Phe Arg Leu Val Leu Arg 
            20                  25                  30          


Leu Ser 
        


<210>  56
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56

Ala Trp Leu Phe Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile Asp 
1               5                   10                  15      


Ala Thr Lys Arg Leu Leu Pro Gln Leu Val Phe Arg Leu Val Leu Arg 
            20                  25                  30          


Ala Ser 
        


<210>  57
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57

Tyr Trp Leu Phe Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile Asp 
1               5                   10                  15      


Ala Thr Lys Arg Leu Leu Pro Gln Leu Val Phe Arg Leu Val Leu Arg 
            20                  25                  30          


Tyr Ser 
        


<210>  58
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58

Phe Trp Leu Tyr Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile Asp 
1               5                   10                  15      


Ala Thr Lys Arg Leu Leu Pro Gln Leu Val Tyr Arg Leu Val Leu Arg 
            20                  25                  30          


Phe Ser 
        


<210>  59
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59

Phe Pro Ile Pro Leu Pro Tyr Cys Trp Leu Cys Arg Ala Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Met Ile Asp Ala Thr Lys Arg Met Leu Pro Gln Leu 
            20                  25                  30          


Val Cys Arg Leu Val Leu Arg Cys Ser 
        35                  40      


