                         SEQUENCE LISTING

<110>  MODERNATX, INC.
 
<120>  POLYNUCLEOTIDES ENCODING METHYLMALONYL-CoA MUTASE

<130>  3529.052PC07/ELE/C-K/DWR

<150>  62/269,089
<151>  2015-12-17

<150>  62/269,092
<151>  2015-12-17

<150>  62/273,112
<151>  2015-12-30

<150>  62/273,108
<151>  2015-12-30

<150>  62/274,727
<151>  2016-01-04

<150>  62/274,733
<151>  2016-01-04

<150>  62/274,722
<151>  2016-01-04

<150>  62/274,726
<151>  2016-01-04

<150>  62/338,478
<151>  2016-05-18

<150>  62/338,456
<151>  2016-05-18

<150>  62/409,343
<151>  2016-10-17

<160>  774   

<170>  PatentIn version 3.5

<210>  1
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  1
atgcttaggg caaaaaacca attattcctg ctgtcgcctc actatctgcg tcaagttaaa       60

gagagcagcg ggtcccggtt aattcagcag cggctactgc atcaacagca gcctctgcat      120

ccagagtggg cagccctggc caaaaagcag ctgaagggga agaatcctga ggacttgata      180

tggcacacac ctgagggaat cagtatcaaa cctctgtatt caaaaaggga cactatggac      240

ctgcccgagg aactgccagg agtcaagccg tttacacgcg ggccctatcc aacaatgtat      300

actttcagac cgtggactat tcggcagtat gcaggattta gtactgtcga agagtccaat      360

aagttctata aggacaatat caaggccggc cagcaggggc tgtctgtagc cttcgatcta      420

gctactcaca ggggctacga ttctgacaat ccccgggtca ggggagacgt cggtatggcg      480

ggagtggcga ttgatactgt ggaagatact aagattttgt ttgatggaat cccactggaa      540

aagatgagtg tttcaatgac gatgaatggt gccgtcatac cagtactcgc gaacttcatt      600

gttacggggg aggaacaagg tgtgcccaag gagaagctca ccgggacaat acaaaatgat      660

attttgaagg agttcatggt ccgcaacact tacatctttc cgcccgaacc aagcatgaaa      720

ataattgccg acattttcga gtatacagct aaacacatgc ctaagttcaa cagcatttct      780

attagcggct atcacatgca ggaggcgggc gcagatgcaa tactagagtt agcatacacc      840

ctcgcagatg gactggaata ttcccgcacg ggtctccagg ccgggttaac aatcgacgag      900

tttgccccac ggctatcttt tttttggggt attggcatga atttctacat ggaaattgcg      960

aagatgcgag caggaagaag actctgggct cacctgatcg aaaaaatgtt ccaaccgaag     1020

aattcaaagt ctttactgct gagagcccat tgtcagacat ccggatggag cttgaccgag     1080

caagatcctt acaacaatat cgtgaggacc gcgatagagg caatggctgc cgtcttcggt     1140

ggcacacaga gcctgcacac aaatagcttt gatgaggccc tcggtctgcc cacagtgaaa     1200

agtgctagaa tcgcgcgaaa tactcagatt ataatacagg aggaatcagg aatccctaaa     1260

gtcgcagatc cgtggggtgg aagctacatg atggaatgtc tgacaaatga cgtatatgat     1320

gcagccctga agctgataaa cgagatagag gagatgggcg ggatggcaaa ggccgtagcc     1380

gagggaatcc ccaagctgag gatcgaagag tgtgcagcca ggagacaggc acgaatcgat     1440

tcaggctctg aggtcatagt aggggttaac aaataccagc tcgaaaagga ggatgcggtg     1500

gaggttcttg ctatcgacaa tacatccgtc cgcaacaggc aaatcgagaa actgaagaag     1560

atcaagtcta gcagggatca ggccctagcc gaaagatgtc tggctgcact cacagagtgc     1620

gctgccagtg gagatggcaa tatacttgct ctcgccgtgg acgcaagtcg ggcccggtgc     1680

acggtgggcg agatcaccga tgcgcttaaa aaggtgtttg gtgaacataa agccaatgac     1740

agaatggtga gcggcgcata ccggcaggaa tttggcgagt ctaaagagat aacctcagca     1800

atcaagcggg tacataagtt catggagaga gagggccggc gcccccgtct tctggtcgcc     1860

aagatgggcc aggatggaca cgaccgcggc gctaaggtaa ttgccaccgg tttcgcagat     1920

ctcggtttcg atgtggatat cggtcctctg tttcaaaccc cccgggaggt cgctcaacaa     1980

gccgttgatg ccgacgtgca tgcagtcggc gtgtctaccc tggccgcggg gcataaaaca     2040

ctcgtgccag agctcataaa ggagctgaat agcttaggta gacctgatat acttgttatg     2100

tgcggagggg ttatccctcc gcaggactac gagtttctgt tcgaggtggg ggtgtccaat     2160

gtgttcggac ctggaacacg cattcccaaa gccgccgtgc aggttctcga cgacattgaa     2220

aagtgcctgg aaaaaaagca gcagtcagtt                                      2250


<210>  2
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  2
atgctccggg ccaagaatca actgttttta ctatcccccc actatttgag gcaggtgaaa       60

gagagttccg gcagcaggct gatacagcaa cggcttctgc accagcagca accactccac      120

ccagagtggg ctgcactagc aaagaagcag ctgaagggaa agaatcctga ggatctgatt      180

tggcataccc ctgaggggat tagcatcaag cccttataca gtaagagaga cacgatggac      240

ctccccgaag aacttcctgg cgttaaacct tttaccagag ggccttaccc tactatgtat      300

acttttcgac cctggactat cagacagtat gccggtttct ccactgtcga ggagagtaat      360

aaattctata aagacaacat caaagccggg caacagggcc tgtctgtcgc atttgacttg      420

gccacacata ggggctatga ttctgataac ccaagagtgc gcggggatgt gggtatggct      480

ggtgtggcta tcgacaccgt ggaagatact aaaattctct ttgacggaat cccactggaa      540

aaaatgagcg tcagtatgac aatgaacggc gccgtcattc ctgttctcgc taactttatt      600

gtcaccggag aagagcaagg cgtaccaaaa gagaagttga ccgggaccat ccagaacgac      660

attttgaaag aatttatggt gaggaataca tatatttttc ctcccgaacc ttcgatgaaa      720

ataatcgccg acattttcga gtatactgct aagcacatgc ctaaatttaa ttctatatca      780

atttccggat atcacatgca agaagctggg gcagatgcca tcttggaact cgcatatacc      840

ttggcggatg gcttggagta tagcaggaca ggcctccagg ctggactcac aatcgacgag      900

tttgccccac ggctgagttt tttttggggc attggcatga atttctacat ggaaatcgcg      960

aagatgaggg ctggccgccg gctgtgggcg catctgatag aaaaaatgtt ccagccaaag     1020

aattccaagt ctctgctgct gcgcgcacac tgtcagacgt ctgggtggag tcttacagag     1080

caagatccct acaacaacat cgttcgaact gccatcgagg ccatggcagc tgtgttcgga     1140

gggacacaga gcctgcacac aaacagcttc gatgaagctc tgggcctgcc aaccgtcaaa     1200

tccgcaagaa tagcacgaaa cacacaaatt ataatacagg aagaaagtgg aatcccaaag     1260

gtagcagatc cttggggcgg cagttacatg atggagtgtc tcacaaacga cgtctacgac     1320

gctgctctga aactcatcaa cgagatagaa gaaatggggg gaatggcgaa agctgtagct     1380

gaggggatcc cgaagctgcg catagaagaa tgcgccgcta ggcgacaggc tagaatcgat     1440

tccggttctg aagtgatcgt cggcgttaat aaatatcagc tagagaaaga ggatgcagtg     1500

gaggtcctgg ccattgataa taccagtgtg cgcaaccggc agattgagaa gctgaaaaag     1560

atcaaatcca gtagagatca agctttggcc gaaaggtgtc tggctgcctt gaccgaatgt     1620

gccgcaagcg gagatggaaa tattctggct ttagcggtgg acgcgagtcg ggcccgttgt     1680

accgtggggg agataaccga tgcgctgaag aaagtgtttg gagaacataa ggccaacgac     1740

cggatggtgt ctggcgccta ccgccaggaa tttggcgagt cgaaagaaat tacctctgct     1800

attaaacgcg tacacaaatt catggaacgg gaagggcgga gaccgcgcct tctggtcgcc     1860

aagatgggcc aagacgggca cgataggggt gcaaaggtga ttgctactgg cttcgctgat     1920

ttgggctttg atgtggacat cggaccgctg ttccagacgc cgcgagaggt cgcccaacag     1980

gccgtcgacg ctgacgttca cgctgtaggg gtgagcaccc tggccgccgg tcacaaaaca     2040

ctggtgcctg aactgattaa agagctgaat tcccttgggc gccctgacat tcttgtaatg     2100

tgcggcggtg tcataccccc acaggactac gaatttctgt tcgaggtggg tgtgtctaac     2160

gtgttcggcc cgggcacaag aattccgaag gccgccgtgc aggttctgga cgacattgag     2220

aaatgcctgg aaaagaagca acagagcgtt                                      2250


<210>  3
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  3
atgttacggg caaagaacca attgttcctt ctcagccccc actatctgcg acaggtgaaa       60

gagtcatccg gatcccggct gatccagcag cggctgcttc accagcagca gccactacat      120

ccggaatggg ctgcgctagc taaaaaacag ctaaaaggaa aaaatcccga ggatctaatt      180

tggcatactc ccgagggcat cagtatcaaa cctttgtact ccaagagaga caccatggat      240

ctaccagagg agttaccagg cgttaagcct ttcactaggg gaccatatcc cactatgtac      300

accttcagac cgtggaccat ccgacagtat gccggattta gcaccgtgga ggagagcaac      360

aagttttaca aggacaatat taaggcgggg cagcagggac tttctgtcgc cttcgatttg      420

gcgactcaca gggggtatga cagcgacaat cctagggtgc gcggcgatgt ggggatggcc      480

ggcgtggcca tcgataccgt tgaagacact aagatcctgt tcgacggtat tcctctcgag      540

aagatgagcg taagcatgac catgaatggc gccgtgattc ctgtcttggc caacttcatt      600

gttacaggag aggaacaagg ggtgcctaaa gaaaaactga ccgggactat ccagaatgat      660

atccttaagg agttcatggt gcgcaacact tatatcttcc cgccggagcc gtctatgaaa      720

attatagctg atatcttcga atacacggcc aagcacatgc ccaaatttaa cagcatctca      780

atatctggat atcacatgca agaggccgga gctgacgcga ttttagagtt agcttacaca      840

ttggcagacg ggttggagta tagcagaacc gggttgcagg caggcctcac catcgacgag      900

ttcgctccta ggctttcctt tttttgggga attggtatga atttctatat ggagatcgcc      960

aaaatgcgag ccggccgtag gctttgggca cacctcattg aaaagatgtt ccagccaaaa     1020

aactccaaat cgctcctctt gagggcacac tgccagacat ccgggtggtc tctgactgaa     1080

caggatccct acaataacat cgtccggact gcaatcgagg caatggccgc agtcttcgga     1140

gggacccaat ccctccacac aaactccttt gatgaagctc tgggcctccc gacagtgaag     1200

tccgcccgca tcgcgcggaa cacccaaatt ataattcagg aagagtccgg cattccaaag     1260

gtggccgacc cctggggcgg ctcttacatg atggagtgtc tgacaaatga cgtttacgat     1320

gcagctctga agcttatcaa tgagatagag gagatggggg gcatggcgaa ggccgtggcc     1380

gaaggaattc ccaagctccg catcgaggag tgtgctgcaa gaaggcaggc taggatcgac     1440

tccggctcag aagtgatcgt gggtgtgaac aaataccagc tggagaaaga agacgccgtg     1500

gaagtgctgg ctatcgataa cacgtcagtg cgcaatcgac aaatagaaaa gctgaagaag     1560

attaaatcca gcagggacca agcactcgct gagcggtgcc tcgcagcgtt gaccgagtgc     1620

gccgctagcg gcgacggcaa catccttgca ttagcagttg acgcctcacg agccaggtgt     1680

acagtggggg aaataaccga tgctctcaaa aaagttttcg gtgaacacaa ggctaatgac     1740

cgaatggtca gcggtgcata ccggcaggaa ttcggagagt caaaagagat caccagtgcc     1800

atcaagaggg tacataaatt catggaaagg gagggcaggc ggccccgcct gttggtagcc     1860

aagatgggac aggacgggca cgaccgagga gccaaggtga tagccacggg ttttgccgat     1920

ctgggttttg atgtggacat cggcccactg tttcagaccc cccgtgaggt tgcccagcaa     1980

gctgtggacg ccgatgtgca cgcggtggga gtttccaccc tagcagccgg tcataagaca     2040

cttgttccgg aactgatcaa agagctgaac tccctcggac gtccagacat tttggtcatg     2100

tgtgggggcg tgattcctcc acaggactat gaatttctgt tcgaggtcgg agtcagtaac     2160

gtgttcgggc caggcacccg aatcccaaag gctgcagttc aggtactgga cgatattgaa     2220

aaatgtctcg aaaaaaaaca gcagtctgtg                                      2250


<210>  4
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  4
atgctgaggg ccaaaaatca gctcttcctg ctttctcctc actacttgcg gcaggttaaa       60

gaatctagcg ggagtcgttt gattcagcag agacttctcc accagcagca gcctctccat      120

ccggagtggg cggcccttgc caagaagcag ttgaagggca agaatccgga ggacttgatc      180

tggcacacgc cggaggggat cagcatcaaa ccgctgtact ccaaaaggga cactatggat      240

ctgcctgagg agctgccagg agtgaagcct ttcacacgcg ggccttatcc taccatgtac      300

accttccgtc cgtggacaat ccgccagtac gcaggtttct ctactgtcga ggagagcaac      360

aaattttaca aggacaatat caaagcaggg caacagggcc tgtctgtagc tttcgacctg      420

gctacacatc gtgggtacga ttccgataac cccagggtgc gaggagatgt tggcatggct      480

ggcgtggcca tcgatactgt tgaagacaca aaaattctat ttgacgggat acctcttgag      540

aagatgagcg tgagcatgac gatgaatgga gccgtcatcc ccgtcctggc gaattttatc      600

gtgactggtg aagaacaagg agtaccaaaa gaaaaactaa ctggcacaat tcagaacgac      660

attctcaagg aattcatggt gcgaaatacc tacatcttcc ctccagaacc atccatgaaa      720

atcatcgctg atattttcga gtacaccgca aagcacatgc ctaaatttaa ctctattagc      780

attagtggat atcacatgca ggaagccggc gcagatgcga tccttgaatt agcctacaca      840

ctagctgatg gcctcgagta ctccagaaca ggcctacaag cgggactgac cattgatgaa      900

tttgctcccc gcctgagctt cttttggggc attgggatga atttctatat ggaaatcgcc      960

aagatgcggg ctggccgtag attatgggcc caccttatcg aaaagatgtt ccagcccaag     1020

aactcgaaaa gtttgctcct tcgagctcac tgtcagacct caggctggtc cctgaccgag     1080

caggacccgt acaataacat cgtcagaacc gccatcgagg ccatggccgc tgtctttgga     1140

ggcacccagt ccttgcacac caatagtttt gacgaggccc tgggtctgcc caccgtcaag     1200

agcgccagaa ttgcaagaaa cacacagatc atcatccagg aagaaagcgg tatcccgaag     1260

gtggcagacc cctggggtgg ctcttacatg atggaatgcc tcacgaatga cgtgtacgac     1320

gcagcgttaa aactcattaa tgagatcgaa gaaatggggg gcatggcaaa ggctgtcgca     1380

gaaggaatcc ctaagctgcg catagaggaa tgcgcggccc ggaggcaggc acgcatcgac     1440

tccggctccg aggtaattgt aggcgtgaat aagtaccagc tggagaaaga agatgctgtt     1500

gaagttctcg ctatagacaa taccagcgtt cggaacaggc agattgagaa gctaaagaaa     1560

atcaagtcat cccgtgacca ggccctggcc gaacggtgtc tcgctgcact caccgaatgt     1620

gccgcttcag gggatggcaa tatcttggcg ctggccgtag acgccagccg cgcaagatgt     1680

actgtcggtg agattacaga cgcactcaag aaggtcttcg gagagcacaa ggccaatgat     1740

cgcatggtca gcggagcata ccgtcaagag ttcggagaga gtaaggagat tacatcagct     1800

atcaagcggg tccacaagtt tatggaaagg gagggaaggc gcccacgact tcttgtcgcc     1860

aagatggggc aggacggcca cgacagaggc gccaaagtca tcgctacggg cttcgcagat     1920

ttgggatttg atgtcgatat tggacctctc tttcagacgc cgcgcgaggt ggctcagcaa     1980

gccgtggatg cagacgtgca cgccgttggg gtatccacgc tcgccgcagg gcacaagact     2040

ctcgtacccg agttgattaa ggagctgaat agtctcgggc ggccagacat cctcgtgatg     2100

tgtggcggcg taattcctcc ccaagattac gagtttctct ttgaggtggg agtttccaat     2160

gtatttggac cgggcacccg gattcctaag gcagccgtgc aagtcttgga cgacattgaa     2220

aagtgtctag agaaaaaaca gcaaagcgtg                                      2250


<210>  5
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  5
atgcttagag cgaaaaacca gctgttcctg cttagcccac actacctacg gcaggtcaag       60

gaaagttctg gttcacgtct catacagcag agactcttac accagcagca gccactgcac      120

ccagagtggg cagccttggc gaagaagcag ctgaaaggaa agaatcctga agatcttatc      180

tggcacaccc cagaaggcat ctcaatcaag cctctgtact caaagagaga tactatggat      240

ttgcccgaag agctgcccgg cgtcaagcct tttactcgag gcccttatcc gaccatgtac      300

acctttcgtc cgtggaccat ccgtcagtac gctggattct ctacagtcga agaaagcaat      360

aagttctata aggacaacat caaagccggc cagcagggtc tgtccgtggc gtttgacctg      420

gccactcatc ggggctacga tagtgataac ccccgggtca gaggggatgt cggaatggct      480

ggcgtagcca ttgacaccgt ggaggacacc aaaattctat ttgatggcat ccccttggaa      540

aagatgagtg tttccatgac catgaatgga gccgtcatcc ccgtgctggc aaattttatt      600

gtaacagggg aagagcaggg agtgcctaag gagaagttaa cgggtaccat tcaaaacgat      660

atattgaaag agtttatggt tcgaaatacc tatatcttcc cccctgagcc atctatgaaa      720

atcatagcag acatatttga gtacactgcg aaacacatgc ccaaattcaa cagcatctct      780

atcagcggct accacatgca agaggccgga gctgatgcta tcttggaact ggcgtacacc      840

ctggcggacg gtctggagta ctcccgtacc ggactccagg ccggcctgac catcgacgaa      900

tttgccccta ggttatcatt tttttgggga attggcatga acttttatat ggagatcgca      960

aaaatgcggg ccggaagaag gctttgggcc cacctcattg aaaaaatgtt ccaaccgaag     1020

aacagtaaat ctcttctcct gcgggctcac tgccagactt ctgggtggtc ccttactgag     1080

caagatccct acaataacat cgttagaaca gcaatcgaag caatggccgc agtttttggc     1140

ggaacgcagt ccctgcatac caatagcttc gatgaggcgc tcggattacc aactgtgaaa     1200

tccgcaagaa tcgctcgcaa tacccagatc atcattcagg aggagagtgg gattcctaag     1260

gtggcagatc catggggcgg ctcgtacatg atggaatgcc ttaccaacga cgtgtacgat     1320

gctgctctga agctcattaa tgagatcgaa gaaatggggg gaatggccaa agcggtggca     1380

gagggcattc caaagctccg catcgaggaa tgtgctgcaa ggaggcaggc caggatcgat     1440

tccggaagcg aggtcattgt tggggtgaat aagtatcagc tggaaaagga ggatgctgtg     1500

gaagtgctgg caattgataa cactagcgtg aggaaccgtc agatcgagaa gctgaaaaag     1560

ataaagagct cgcgagacca agccttagca gagcggtgcc ttgcggcact aacagaatgt     1620

gctgccagtg gggatggaaa cattcttgca ctggctgtcg acgccagtcg agcaaggtgt     1680

acagtgggag agatcacaga cgctttgaaa aaagtgttcg gagagcacaa ggcgaacgac     1740

cgcatggtgt caggagccta ccgccaggaa ttcggcgaaa gtaaagagat tacttcagcc     1800

attaagaggg tccacaagtt tatggaacgt gagggcaggc ggcccagatt actcgtggcc     1860

aagatgggtc aagacggcca cgataggggt gcaaaagtga ttgcaaccgg cttcgcagac     1920

cttggatttg atgtggacat tgggccactt tttcagaccc ctagagaagt ggcacagcag     1980

gcagttgatg ccgatgtaca tgccgtggga gttagtaccc tcgcggctgg ccacaagaca     2040

ctagtacctg agcttattaa agagctgaat agcctcggta ggcctgatat ccttgtgatg     2100

tgtggcggcg ttatacctcc acaggattac gagttccttt tcgaggttgg tgtttcaaac     2160

gtctttggtc ctggcacgcg tatacctaaa gcagcagtgc aagttttgga tgacattgag     2220

aaatgtctgg aaaagaaaca acagtcagtg                                      2250


<210>  6
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  6
atgctgcgcg ctaagaatca gctgttcctg ctctctcctc attatctccg ccaggttaaa       60

gaaagctccg ggtctagact cattcagcag aggttgctgc accaacagca gcctctgcac      120

ccagaatggg ctgcactggc caagaagcag cttaaaggga aaaacccgga agacctgatt      180

tggcataccc ccgaggggat tagcattaaa ccattgtatt ccaaacgaga tacgatggat      240

ctgcccgagg agctgcccgg cgtgaagcct tttacaaggg gtccttatcc cactatgtat      300

acatttagac cctggaccat tcgccagtac gccggattta gtacagtcga ggagagcaac      360

aaattttaca aggacaacat aaaagctggg caacagggcc tgagtgtcgc attcgacctc      420

gccactcacc gaggatacga ctccgataat ccgcgggttc gcggtgatgt gggcatggca      480

ggagtcgcaa ttgatacggt ggaggacacc aaaatcctgt tcgacggtat ccccctggag      540

aaaatgagcg tcagtatgac aatgaatgga gccgtgattc cagtcttggc caatttcatt      600

gtaacaggag aggaacaggg cgtccctaag gagaaactaa cagggaccat tcagaacgac      660

atacttaagg agtttatggt gcggaacacc tatatctttc ccccggagcc ttcaatgaag      720

attatcgcgg atatttttga atacacagca aagcatatgc caaaattcaa tagcataagc      780

atcagcggtt atcacatgca ggaagctggg gccgacgcca tcctggagct tgcttatact      840

ctggcggatg gcctcgagta ctcgcgcact ggattgcagg ccggcttgac aattgacgag      900

ttcgccccca gacttagttt cttttgggga atcggtatga acttttatat ggaaattgcc      960

aagatgcgcg ccggcaggcg cctgtgggcg cacctgattg aaaagatgtt tcaacccaag     1020

aacagtaagt cactgctctt gcgggcccat tgccagacta gcggatggag cctgaccgag     1080

caggatccgt acaacaacat tgttcggact gccatcgagg ccatggcggc cgtgtttggg     1140

gggacacaga gcctccatac aaattccttc gacgaggctc tcggactgcc gacagtgaaa     1200

tctgctcgga ttgcccgcaa tacacaaatc ataattcagg aggagtcagg tataccaaag     1260

gtggccgatc cttggggagg cagctatatg atggagtgcc taaccaacga tgtgtacgac     1320

gcagctctga agctcattaa cgagatcgag gaaatgggcg gtatggccaa ggccgtggct     1380

gagggtattc ccaaacttcg catcgaagag tgtgccgcga ggcgccaggc tcgaattgac     1440

tccggaagtg aggtgatcgt tggagtcaat aagtaccagc ttgagaagga agacgctgtt     1500

gaggtcttag ccattgacaa tacctcagtt agaaatcgcc agattgaaaa actgaaaaaa     1560

atcaagtcct cgcgcgacca ggctctcgct gagcgatgcc tcgcggcact gacagagtgt     1620

gctgcctcgg gcgacgggaa tattctcgcc ttggccgtgg acgcctcacg cgcgcgatgt     1680

accgtcgggg agattacaga tgcattgaag aaagtgtttg gagagcacaa agcgaatgac     1740

cgcatggtat ccggagctta tcgtcaggag ttcggtgagt cgaaagaaat tacctcagcc     1800

attaaaagag tgcataaatt catggaaagg gaagggagga ggccccgcct acttgtggct     1860

aaaatggggc aggacggcca cgacagaggc gctaaagtaa tcgccacagg cttcgcagac     1920

ttgggctttg acgtcgacat cggccctctc ttccaaaccc ccagggaggt ggcccagcag     1980

gccgttgatg ctgacgtgca tgcagtcgga gtatcaacat tagccgccgg ccacaagaca     2040

ctcgtcccag aattaattaa agaactgaat agtctcgggc ggccagacat tttggtcatg     2100

tgcggagggg tgattccgcc tcaggattat gagtttctat tcgaagtcgg agtgagtaat     2160

gtcttcggcc caggtaccag gatacccaag gctgcggtgc aggtcctcga tgacattgag     2220

aagtgcctgg agaagaaaca gcagagcgtc                                      2250


<210>  7
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  7
atgctacgcg ccaagaatca gctctttctg ctgtctccgc actacttgcg acaggttaaa       60

gagtcttcgg gctcccggct gattcagcag cgcctgctac accagcaaca acctctgcac      120

ccagaatggg ctgctttggc aaaaaagcaa ttgaaaggta aaaaccccga ggacctcatt      180

tggcataccc ccgagggaat tagtataaag ccattgtaca gtaagagaga tacaatggat      240

ttaccagagg aactccccgg ggtgaaacca ttcacaaggg gtccataccc aaccatgtac      300

accttcagac catggactat ccggcagtac gctgggttct caacagtgga agagtcaaac      360

aagttttata aggacaatat caaagctggc cagcagggtt tgtcagtggc ttttgatcta      420

gccacgcacc gtggctatga tagcgacaac ccaagggtgc gaggggatgt cggcatggcc      480

ggcgtcgcca tagatacagt ggaagacacc aaaatcctgt ttgacggaat acctttggag      540

aaaatgagcg tcagcatgac catgaatggg gctgtcattc ctgtgttggc caactttatc      600

gtcaccggtg aggagcaggg cgttccaaaa gagaagctta ccggaactat tcagaacgat      660

atcctgaaag agtttatggt gcgtaacacc tacatttttc cccccgagcc atctatgaag      720

atcatcgcgg acatattcga atatacggca aagcatatgc ctaagtttaa cagcatctcg      780

atcagcggct atcatatgca ggaagcaggg gccgatgcca tcctcgagct cgcttatacc      840

ctggccgacg gtctggaata ttcccgtaca ggcctacaag ccggtttgac catcgatgag      900

ttcgcaccca gattatcttt tttttggggg attggaatga atttttacat ggaaatagca      960

aagatgcggg ctggacgtag gctgtgggct caccttattg agaaaatgtt tcagccgaag     1020

aactcaaaat cgctcttgct gagagctcat tgccagactt ccgggtggtc tctgactgaa     1080

caggaccctt ataacaatat cgtccgtact gctattgagg caatggccgc agtgtttggc     1140

ggtacccagt cattgcatac aaactcattc gacgaagctc tgggactccc aacggtaaaa     1200

tcagcacgca ttgctaggaa cacacagatc atcattcagg aagaatccgg aattccaaag     1260

gtggccgatc cttggggagg ctcttatatg atggagtgcc tgacgaacga tgtgtatgat     1320

gccgccctca agcttattaa cgaaatcgag gaaatggggg gcatggccaa agctgtagcg     1380

gagggtatac ctaagttgcg cattgaagaa tgcgccgctc gtagacaggc cagaattgat     1440

tctggctcgg aagtgattgt gggcgtaaac aaataccagc tcgagaagga ggacgccgtt     1500

gaggttttgg caatcgacaa tactagcgtg cgcaaccgcc agatagaaaa gctgaaaaag     1560

atcaagtcta gcagagacca agctcttgcc gagcgctgtc tggctgcact cactgagtgt     1620

gccgcaagtg gggacggaaa cattctggcc ctagctgtag acgcttcccg cgcgaggtgt     1680

acggtcggcg aaatcacaga tgccctgaaa aaagtgttcg gggaacataa ggcaaatgat     1740

aggatggtgt cgggggccta ccgtcaagaa tttggagaat ccaaggagat taccagcgcc     1800

ataaaaaggg tgcataagtt catggagaga gaggggagac gccctaggct gctcgttgct     1860

aaaatgggac aggacggcca cgatcgaggc gccaaggtga ttgccaccgg tttcgctgac     1920

ttaggattcg atgtggacat tggtccgttg ttccagacgc cacgcgaggt ggcacagcaa     1980

gccgtggacg ccgatgtgca tgccgtgggc gtgtcgactt tggcagcagg gcacaagacc     2040

ctggttcccg agcttatcaa ggagctaaat agccttggcc ggcccgacat cctggtcatg     2100

tgcgggggag ttattccccc ccaggactac gagtttctat tcgaggtggg agtaagtaat     2160

gtgtttggac cgggtacgag gatccccaag gccgccgtcc aggttcttga cgacatagaa     2220

aaatgtttgg aaaaaaagca gcagagcgtg                                      2250


<210>  8
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  8
atgctgcggg caaaaaatca gctgtttttg ctttccccac actatctccg acaggtcaaa       60

gagagcagcg gaagtaggct catccagcag aggctgctac accaacagca gcctttgcac      120

cctgaatggg ctgccctggc gaaaaagcaa ctgaagggca aaaaccccga ggacctgatc      180

tggcatactc ccgaaggcat atcgataaag cccctgtatt caaagcgaga caccatggat      240

ctccccgaag aacttcctgg cgtgaaacct ttcacccggg gcccctaccc tactatgtat      300

acattccgcc catggaccat ccggcagtat gcaggcttta gcactgtgga ggagtctaat      360

aagttttaca aagacaacat aaaggcggga cagcaaggac tctctgtcgc attcgacctg      420

gccacccatc gcgggtacga tagcgataat ccaagagtga gaggggacgt cggaatggcc      480

ggtgtggcaa tcgataccgt agaggatacc aaaatccttt tcgacgggat acctctcgaa      540

aaaatgtcag tgtccatgac gatgaatggc gctgtgatac cagtgctggc caacttcata      600

gtgaccggcg aggaacaggg tgtccccaag gagaagctga ctgggaccat ccagaatgac      660

attctcaagg agttcatggt aagaaatacc tacatattcc ctcctgaacc tagtatgaaa      720

ataattgccg atattttcga gtatactgct aagcatatgc cgaagtttaa ttctattagc      780

atttctggct accatatgca ggaggctgga gccgacgcta tcttagaact tgcatacacc      840

ctggccgacg gactcgaata tagtaggaca gggttgcagg ctggcttaac tattgacgag      900

ttcgcaccta gattgtcatt tttttggggt ataggcatga atttctatat ggaaattgcc      960

aagatgcggg cagggcgcag attatgggcc cacctgattg agaagatgtt tcagccaaaa     1020

aatagcaaga gcctgttgtt gagagctcac tgccagacca gcggttggtc tctcaccgag     1080

caggacccct acaacaatat cgtgcggact gcaatcgagg ccatggccgc tgtgttcggt     1140

ggcacacaga gcctacacac taacagtttt gatgaggcac ttggtctccc cacggtgaaa     1200

tcagcccgaa tcgcccgtaa tacccagatc atcatccaag aggaatccgg aatcccaaag     1260

gtcgcagatc cctggggagg ctcttatatg atggagtgtt tgacgaacga cgtttacgat     1320

gctgcactca agttaattaa cgagatcgag gagatgggag gtatggctaa agccgtagct     1380

gaggggattc caaaattgag gattgaagag tgtgccgccc gacggcaggc aaggattgat     1440

tccgggagcg aggtcatcgt gggcgtcaat aaatatcagc tggagaaaga agacgcagtt     1500

gaagtacttg ccattgataa caccagtgtg aggaaccggc aaattgaaaa attgaaaaag     1560

atcaagtctt cacgagacca agccctggcg gagcgatgcc tggctgccct gacggaatgt     1620

gccgcatctg gagacggcaa tatactggcg cttgccgtgg atgcatcacg ggccaggtgt     1680

accgtaggcg agattactga tgcccttaaa aaggtgttcg gggagcacaa ggctaacgac     1740

cggatggtgt ctggcgcgta taggcaggaa ttcggcgagt ccaaggagat aacttccgct     1800

ataaagaggg tccataaatt tatggagaga gaggggagac gcccaaggtt acttgtggca     1860

aagatgggac aggatggaca tgatagaggg gcaaaggtta tcgccacggg gtttgctgac     1920

ctggggttcg atgtggatat cggccccctc ttccagaccc caagagaggt ggcccagcag     1980

gccgtcgacg ccgacgtaca cgccgttggc gtgtccacgc tggcggccgg ccacaagaca     2040

ctagtgcctg agcttatcaa agaattaaac agtctcggga gacctgacat tcttgtgatg     2100

tgcggagggg ttattccacc gcaggattac gaattcctgt tcgaagttgg cgttagcaat     2160

gtcttcgggc ccggcaccag aattcctaaa gctgccgtgc aggtccttga tgacatcgaa     2220

aaatgtctgg agaagaaaca gcaaagcgtg                                      2250


<210>  9
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  9
atgcttagag ccaagaatca gttgttcctc ctgagccctc actatctccg ccaggttaaa       60

gagagcagtg gctcacggct gatccaacag cgcctgctgc accagcagca acccctccac      120

cccgaatggg cagccctcgc taaaaaacag cttaaaggga agaatcctga agacctgatc      180

tggcacaccc ctgaaggcat tagtataaaa ccactgtatt ccaagcgcga cactatggac      240

ctgccagagg agctgccagg agtgaaacct tttacaagag ggccgtaccc caccatgtat      300

acttttcggc cctggaccat ccgccagtac gctggattca gtacagtcga agagtctaat      360

aagttctata aagacaacat aaaggctggc cagcaaggac tctctgtagc attcgacctt      420

gcgactcacc gaggctatga tagcgataat cctcgcgtga ggggagatgt tgggatggcc      480

ggagtggcaa tagataccgt cgaagacacc aaaatactct tcgatgggat ccctcttgaa      540

aaaatgtccg tgagcatgac catgaatggt gccgttatcc cggttctcgc gaactttatt      600

gtgaccggtg aagagcaggg agtgcctaag gagaaactga ctggcactat ccagaacgac      660

attctcaaag agttcatggt ccgcaacact tacatcttcc cacccgagcc ttccatgaaa      720

ataatcgctg acatattcga gtacactgct aaacatatgc ccaagtttaa ctcgatcagc      780

attagcggct accatatgca ggaggctggc gccgacgcca tcctcgagct cgcctatact      840

ttggccgacg gcctggaata ctcgaggaca gggcttcagg ccggcttaac aatcgatgaa      900

tttgccccgc gcttgagctt cttttgggga attgggatga atttctacat ggaaatcgca      960

aaaatgcgtg ccggtagacg gctatgggct cacctcattg agaagatgtt tcagcctaag     1020

aacagcaaga gcctgctgct gagagcccac tgtcaaacgt cgggctggtc gcttacagag     1080

caggatccct acaacaacat tgtgcgaacc gccattgagg caatggccgc cgtattcgga     1140

ggcacgcaat ccctgcatac caactctttt gacgaggcgc tgggtctgcc cactgtgaaa     1200

tcggccagga ttgctcgcaa cacacaaatc atcatccaag aagagtccgg gattcccaag     1260

gttgccgatc catggggggg cagctacatg atggagtgcc ttactaacga tgtttatgat     1320

gctgcactta aactgatcaa cgaaatagaa gagatggggg ggatggcaaa ggccgtcgcc     1380

gaagggatac ccaagctgag gatcgaggaa tgcgcggctc gacggcaggc ccggatcgac     1440

tccggaagcg aggtcatcgt cggcgtaaat aaataccaac tggaaaagga ggacgcggtt     1500

gaggtgttgg ccatagacaa cacctcagta cgaaaccgac agatcgagaa attaaaaaag     1560

atcaaatcaa gccgcgatca ggcactggct gagcggtgcc tggccgcact gactgagtgt     1620

gcagcctcag gagacggtaa catcctcgct ctggccgtgg atgcaagtcg ggcccgctgt     1680

acggtggggg agatcactga cgctctgaaa aaagtttttg gagaacacaa ggcaaacgat     1740

aggatggtta gcggcgcata ccggcaggag ttcggtgaat ctaaagagat tacctctgca     1800

atcaagcggg ttcacaagtt catggagcga gaaggcaggc ggccacggtt gttagtggct     1860

aaaatggggc aggatggtca cgacagaggg gctaaggtga ttgccaccgg attcgccgac     1920

ctagggttcg acgtggatat tgggcctttg ttccagacac cacgggaggt ggctcaacaa     1980

gccgtggacg cggatgtgca cgccgtgggg gtgtccaccc ttgccgcagg ccacaaaacc     2040

ctggtgccag aactgattaa ggagctcaat tcattgggca gacctgacat tctggtgatg     2100

tgcgggggcg taattcctcc ccaggactac gagtttctgt tcgaagtggg cgtgagtaac     2160

gtgttcggac ccggtaccag aatccccaag gccgccgtcc aggtgctgga cgacatcgag     2220

aaatgtctgg aaaagaagca acagtctgta                                      2250


<210>  10
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  10
atgctgcggg ctaagaatca actgttcttg ttgagccccc actatctgag gcaagtgaaa       60

gagagtagtg gaagccggct catccaacaa agacttctgc accagcaaca acctctgcat      120

ccggagtggg cggcgctggc aaagaaacaa ttgaagggta aaaatccaga ggacctgatt      180

tggcacaccc cagaggggat ttcgatcaaa cctctgtaca gcaagaggga cactatggac      240

ttgcctgagg agctgccagg agtcaagcca ttcacaaggg gaccatatcc tacaatgtac      300

acttttaggc cctggacaat tagacaatac gccggttttt caactgtcga ggaaagcaat      360

aaattctaca aggacaacat caaagctggg cagcaaggtc tttcagtggc tttcgacctg      420

gcgactcaca ggggttacga ctctgataac cctcgagtgc gaggggatgt cggaatggcc      480

ggggtggcca tagatacagt ggaggacacc aagattctat tcgacgggat accgctcgag      540

aagatgtcag tttctatgac aatgaacggt gcggtcattc cggtcttggc aaactttatt      600

gttacaggtg aggaacaggg ggttccaaag gaaaaactga ccggaactat acaaaatgac      660

atcttgaagg aattcatggt gcgcaacacc tacattttcc cgccagaacc aagcatgaaa      720

attatcgccg acatattcga gtatactgct aaacacatgc ctaaattcaa cagcattagc      780

atcagcggct atcacatgca agaggccggt gcggacgcca ttcttgaact ggcatacacc      840

ctcgccgatg ggctggagta ctcccgaact gggctccagg ccggactaac aatcgacgag      900

ttcgccccgc gtctctcttt cttctgggga atcggaatga acttctacat ggagattgca      960

aaaatgagag cggggcgcag actatgggca caccttatag aaaaaatgtt ccagcccaaa     1020

aattctaaaa gcctgctact gagagctcat tgtcaaactt ctggctggag tttgaccgaa     1080

caagatccat ataataatat tgtccggaca gcgattgagg ctatggccgc cgtctttggc     1140

ggtactcaga gccttcacac aaattctttt gatgaagcac tggggctgcc gacagttaag     1200

agtgccagga tagccaggaa cacacagatt attattcagg aggagtccgg catacccaag     1260

gtggctgatc cctggggcgg gagctacatg atggagtgcc ttacgaacga tgtctatgac     1320

gccgctctga agctgattaa cgagatcgag gagatgggtg gtatggccaa agctgtagcc     1380

gaggggattc ctaagctgag aatcgaggag tgcgcagctc ggagacaggc tcgcatcgac     1440

tctgggtccg aagtcatagt tggggtgaac aagtatcagc ttgaaaagga ggatgccgtg     1500

gaggtgctgg ccatagataa tacgtcggtg agaaatagac agattgagaa attaaaaaaa     1560

attaagagta gcagggatca agccctcgct gagcggtgcc tcgcagctct caccgaatgt     1620

gccgcaagcg gcgacggtaa catcctcgct ttagcagtcg acgccagcag ggcccgctgt     1680

actgtgggag agatcaccga tgccctgaaa aaggtcttcg gggaacataa agccaatgat     1740

cgcatggtaa gcggggctta tagacaagaa ttcggtgaga gcaaggagat cacgtccgca     1800

atcaaaaggg tccataaatt catggagaga gagggtagac gcccaagact cctcgtggca     1860

aaaatggggc aggatggaca tgaccggggt gccaaagtga tcgccaccgg attcgcagat     1920

ctgggcttcg atgtcgacat tggcccgctc tttcagacac ctcgtgaagt ggcgcagcag     1980

gccgtcgacg ctgatgtgca cgctgttggg gtgagcactc tcgcagccgg tcacaaaacc     2040

ctggtgccgg aactaatcaa agaactcaac tctctcgggc gtccagacat cctcgtgatg     2100

tgtggcggtg tcatcccacc ccaggattac gagtttttat ttgaagtggg tgtctctaat     2160

gtgttcggcc ccggaacacg cattcccaaa gctgcagtcc aggtcctaga tgacatcgaa     2220

aagtgccttg agaagaagca acagagcgtc                                      2250


<210>  11
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  11
atgttaaggg caaagaacca gcttttcctc ctgagccctc attacctacg gcaggtgaag       60

gagagctccg gaagccgcct cattcagcaa cgcctcctgc atcagcagca gccccttcac      120

cccgaatggg cggccctggc taagaagcaa ttgaagggta agaacccaga ggacctgatt      180

tggcatactc ccgagggcat ttctatcaaa cccctgtaca gcaagcgcga caccatggac      240

ctaccagaag agttgccagg cgtcaaaccc tttactcggg gcccttatcc taccatgtac      300

accttccgtc cctggacaat ccggcagtat gctggattta gtacagtcga ggagagcaat      360

aaattttata aggacaatat aaaagcaggt cagcagggct tgtccgttgc ctttgaccta      420

gcgacacata ggggatatga ttccgacaat ccccgggtga ggggtgatgt cggcatggct      480

ggagttgcta ttgacaccgt ggaagacact aagatcctat tcgatggaat ccccctggag      540

aaaatgtccg tgagcatgac catgaacggc gctgtgattc ccgtcttagc aaactttatt      600

gtgacaggcg aggagcaggg cgtgccaaaa gagaaattga ctggtaccat tcagaacgac      660

atactgaagg agttcatggt gcggaataca tatatatttc ccccagaacc gtctatgaaa      720

atcattgcgg acatcttcga gtacaccgcg aagcacatgc ccaaatttaa tagcatcagt      780

atcagcgggt atcacatgca ggaggccggc gcagacgcga tccttgaact cgcgtatacc      840

ttggctgatg gactcgaata ttcaaggacc gggttgcaag cagggctgac catcgacgag      900

tttgcacctc gactgagctt tttctggggg atcgggatga acttttatat ggagatcgcc      960

aagatgcgtg cggggcgacg cttatgggcg catcttattg aaaaaatgtt tcaacctaaa     1020

aacagcaagt cgctgctcct ccgggcgcac tgccagacta gcgggtggag cctgaccgaa     1080

caagatccct acaataacat agttaggacc gcaatagaag ccatggcagc ggtgtttggc     1140

gggacgcaga gtctccacac caacagcttc gatgaggccc tgggacttcc cacagtgaag     1200

tctgccagga tcgcccgcaa cacccagatt atcatacaag aagagtctgg aatcccaaag     1260

gtggccgatc cctggggagg gtcttatatg atggagtgtc tgactaacga cgtgtacgac     1320

gcggccctga aactaatcaa tgagatcgag gagatggggg gcatggctaa agcagtggcc     1380

gaagggatac cgaagctaag aattgaggaa tgtgctgcaa ggagacaggc gcgaatcgat     1440

tccggctccg aggtgatcgt gggtgtcaat aagtatcagc tggagaagga ggatgctgtc     1500

gaggtcctgg cgatcgataa cacatcagtc aggaatagac agattgagaa acttaaaaag     1560

attaagagct cccgggatca ggctcttgcc gagcgctgcc ttgctgctct tacagaatgt     1620

gcagcaagtg gggacggtaa catactggcg ctggcggtcg atgcctcaag ggcaagatgt     1680

accgtcggtg agatcaccga cgcgctgaag aaagttttcg gcgaacacaa ggccaacgac     1740

cgaatggtta gcggtgctta tagacaggaa ttcggcgagt ccaaggaaat aacatccgct     1800

atcaagagag ttcataaatt catggagcga gaggggcgta gaccccgcct cctggtcgct     1860

aagatggggc aggacggtca cgacagaggg gcaaaggtca ttgccacagg atttgcagac     1920

ttagggtttg acgtcgacat aggaccttta tttcaaaccc caagagaggt ggctcagcaa     1980

gcagtggacg ccgatgttca tgccgtagga gtgagtaccc tggcagccgg ccacaagacc     2040

ctagtgccag aactgattaa agaactcaac agtttaggaa ggccagatat cctggtgatg     2100

tgcggcggcg taatccctcc acaagactat gaattccttt tcgaagttgg cgtttccaat     2160

gtatttggcc ctggcacaag aatacccaag gccgcagtgc aggtgctcga cgacatcgaa     2220

aaatgcctgg agaagaagca gcaatcagtt                                      2250


<210>  12
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  12
atgctgcgcg caaaaaacca gttatttctg ctttctcccc attacctgag acaggtgaaa       60

gaatcaagcg gctctcgact gatccagcaa cggctcttac atcagcagca gccgttgcat      120

cctgagtggg cagcactggc caaaaagcag ctgaagggca aaaatcccga ggacctaatc      180

tggcataccc ccgagggaat cagtattaag cctctttatt ctaaacggga caccatggac      240

ctcccagaag aactgcctgg agtaaaacct ttcacccgag gcccttatcc tacaatgtac      300

acgtttagac catggaccat cagacagtac gctgggttct caacagtgga ggaatccaat      360

aagttctata aagacaacat caaagcaggc caacagggac tgagcgttgc ctttgatctg      420

gcaacccacc gcggttacga tagcgacaac cccagggtaa gaggcgacgt cggaatggca      480

ggggtagcga tagacactgt tgaggacacc aaaattctgt tcgatggtat ccctctggaa      540

aagatgagcg tgtccatgac tatgaatgga gcagtgatcc ctgtgctggc aaactttatc      600

gttaccggcg aggagcaggg cgtgccaaag gaaaaactga cggggactat tcaaaacgat      660

atcttaaagg agtttatggt gcgcaacacg tatatatttc caccagaacc tagcatgaaa      720

atcatcgctg atatattcga gtacacagca aaacatatgc ccaaatttaa ctccattagc      780

atatccggat accacatgca ggaagccgga gcggacgcaa tcctcgagct agcgtatact      840

ctcgcggacg ggctcgagta tagcagaact gggttgcaag ctggcctgac catcgatgaa      900

tttgcaccca gactctcttt tttttggggg ataggcatga atttttatat ggaaatcgca      960

aaaatgagag ccggccggag attgtgggcc cacttgatcg agaagatgtt ccagccaaaa     1020

aacagcaaat cactgttgct tcgagctcat tgtcagacat cgggatggtc tctgaccgaa     1080

caggatccct acaacaacat tgtgagaacc gccatcgagg ccatggctgc agtcttcgga     1140

ggaacacaaa gtctccatac taactcattc gatgaggctc tgggactgcc aactgtaaaa     1200

tctgccagaa ttgctagaaa cacccagatt attattcagg aggagtccgg tatacctaag     1260

gttgcagatc cgtggggggg cagttacatg atggagtgtc tgaccaacga cgtgtatgat     1320

gccgcactga agctcattaa tgagatcgag gagatgggtg gcatggccaa agctgtggcg     1380

gaaggaatcc ccaaactgcg aattgaggaa tgcgcagcta gacgtcaggc acggatcgac     1440

agcggatccg aggtgattgt gggggttaac aaatatcagc tcgaaaagga ggatgcagtt     1500

gaagtgctcg caatcgataa tacgtcggtg cgcaataggc agattgagaa gctcaaaaag     1560

attaagagct caagggatca ggctctggct gaaagatgtc tcgctgccct gacagagtgc     1620

gcagcaagtg gagacggcaa catccttgcg ttggcagtcg atgcttcaag agctcgctgt     1680

accgtcgggg agatcacaga cgctctaaag aaagtttttg gggaacacaa ggctaacgat     1740

cgaatggtgt ccggtgcata tcgccaagaa tttggtgaga gcaaggagat caccagcgcg     1800

attaagcggg tccataaatt tatggagaga gaggggcgta gaccgcggtt actggttgct     1860

aagatggggc aagacggcca cgatagaggc gccaaagtga tcgccaccgg gttcgcagac     1920

ctcggatttg acgttgacat tggtccactt tttcagaccc cacgcgaggt ggcacagcag     1980

gcagtcgacg ccgacgtaca cgcagtgggc gtatcaactc tggctgctgg gcacaaaacc     2040

cttgtgccgg agctcatcaa agagctgaac tcgctcgggc gccccgatat tctcgttatg     2100

tgtggggggg tcattcctcc ccaggactac gagttcctct tcgaggtcgg ggtatcaaat     2160

gtgtttggac ccggaacacg aatacccaag gcagccgttc aggtgctgga tgatattgag     2220

aagtgcttag aaaagaaaca gcagtcagtg                                      2250


<210>  13
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  13
atgctcaggg caaagaacca gttatttctg ttgtcacccc attacctcag gcaggtgaag       60

gaatctagcg ggagccgcct gatacagcag cgtcttttgc accagcaaca gcctttacat      120

ccagagtggg cagctctggc gaagaaacaa cttaagggga agaatcccga ggacttgatt      180

tggcacactc ccgaaggtat tagcattaaa ccgctatact ccaaaagaga tacaatggac      240

ctgcccgaag agcttcccgg agtgaagcca tttacacgcg gcccatatcc aaccatgtat      300

acctttcgac cttggaccat aagacaatat gccgggtttt ctaccgtgga ggaatcaaac      360

aaattctata aggataacat caaggccggg cagcagggcc tcagcgttgc ctttgacctg      420

gccactcaca gaggctatga ttccgacaat ccccgagtga gaggggatgt tgggatggcc      480

ggagtcgcca tagatacagt tgaagatacg aagattctct tcgatggaat ccccctcgag      540

aaaatgagtg taagcatgac catgaacggg gcagtgatac ccgtgctcgc caattttatc      600

gtgactggcg aagaacaagg ggtgcccaaa gaaaagctca caggcaccat tcagaacgac      660

atactgaagg agttcatggt gcgtaacact tacattttcc cccccgaacc ttcaatgaag      720

attatagccg atatattcga atacacagcc aaacacatgc ccaagttcaa cagcattagt      780

attagtgggt accatatgca agaagccggt gccgatgcta tactggagct tgcgtacaca      840

ctcgcagacg ggctagagta tagccgtacc ggcctccagg ccggtctaac tattgacgag      900

ttcgcacccc gtcttagttt tttctgggga attggtatga atttctatat ggagatcgca      960

aagatgagag ctggtcggag actctgggcc cacttaattg agaaaatgtt tcagcctaag     1020

aattccaagt ccttgctgct ccgggctcat tgtcaaacta gcggttggtc tttaactgag     1080

caagacccct ataataacat tgttcgcact gctattgagg ctatggcggc ggtgttcggc     1140

gggactcaga gcctgcacac aaacagcttt gatgaagctc ttggacttcc aaccgtcaag     1200

tccgccagaa tagcccgaaa cactcagatt atcatccagg aggagtcagg aattcctaag     1260

gtcgctgatc catggggcgg gtcttacatg atggagtgcc tcaccaatga cgtctacgat     1320

gccgccctca aactgataaa cgaaatagag gagatgggag ggatggccaa ggcagtagcg     1380

gaaggtatcc caaagctccg gatcgaggag tgtgcggcgc gccggcaagc tcggatcgat     1440

tccggaagcg aggtgatcgt cggggtgaac aagtatcagc tagaaaagga agatgctgtg     1500

gaggttctcg caatagataa cacatcagta cgaaacagac agatcgagaa actgaagaag     1560

atcaaatcat caagagatca ggccttggct gagagatgct tggctgcatt gacagagtgc     1620

gccgcaagcg gggatggcaa tatccttgca ttggctgtcg acgcttcccg tgccaggtgc     1680

acagtaggtg aaattaccga cgctttgaaa aaggtgttcg gagagcacaa ggccaatgat     1740

cgcatggttt ccggcgccta ccgacaggag ttcggcgaat caaaagagat cacatccgca     1800

atcaagaggg tgcacaaatt tatggaacgc gaggggagac ggccgcgcct ccttgttgcg     1860

aagatgggac aggatggaca cgacagggga gctaaggtca tagccacggg gttcgcagac     1920

ctaggtttcg acgtggatat cggaccgcta ttccagacac ctcgggaagt agctcaacag     1980

gccgttgacg ccgacgtaca cgccgtgggc gtctctaccc tggcggctgg tcataaaaca     2040

ctggtgcctg agttgatcaa ggagctcaac tccctggggc gtccagacat attagtgatg     2100

tgcgggggag tcattccacc acaggattat gagtttttat ttgaggtggg cgtatctaat     2160

gtgtttggcc ccggtacacg catcccaaag gcagccgtgc aggttctgga cgacatcgag     2220

aagtgtctcg agaagaagca gcagtctgtg                                      2250


<210>  14
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  14
atgctgagag cgaaaaacca gctattcctg ttatcaccac actacctgag acaggtaaag       60

gagtcgtcag ggagccggct tattcaacaa cgactgctcc atcaacagca gccactacac      120

ccagaatggg ccgcactggc taaaaaacaa ctgaagggca agaaccctga ggatctgatc      180

tggcacacgc ctgaaggaat ctcaatcaaa cctctgtaca gcaagcgcga cacaatggat      240

ctgccagagg agctgcctgg agttaaaccc ttcaccaggg gcccttaccc aactatgtac      300

acttttagac cttggacgat taggcagtat gctggattct caacagttga ggagtcaaat      360

aaattttaca aggacaacat caaggccgga cagcagggac tctctgtcgc ctttgaccta      420

gccacacata gagggtacga ctcagataat ccccgggtcc gtggcgacgt tggaatggca      480

ggagtggcta ttgataccgt ggaggatacc aagatactct ttgacggcat tcccctggag      540

aagatgagcg tgtctatgac aatgaacggg gcagtgatac ccgtgctagc gaatttcatt      600

gtgacgggcg aggagcaggg cgtgcctaag gaaaaattga ccggtactat tcagaacgac      660

attctgaaag agttcatggt gcgcaacaca tatatctttc ctccagaacc atccatgaaa      720

ataatcgccg acatattcga atacactgcc aagcacatgc ccaaatttaa ctctatatct      780

atttctggtt accatatgca agaagctgga gcagacgcta tccttgaatt ggcctacacc      840

ctggccgatg ggcttgagta ctcccgaact ggattgcagg cgggacttac aatcgacgaa      900

ttcgcccccc ggctcagttt tttctggggt ataggaatga atttctatat ggagatcgcg      960

aaaatgcggg ctgggcggag actctgggcc cacttgatcg agaagatgtt tcagcccaag     1020

aacagcaaat ccctgctcct gagggcccac tgccagacaa gcggctggag cctcacagag     1080

caggatccct ataataacat tgtgaggacc gctattgagg ccatggctgc ggtctttgga     1140

gggacccaat ctttacacac taattccttt gacgaggcct tagggctgcc tacggttaag     1200

agtgctcgca ttgctaggaa cacccaaatc attattcagg aggagtcagg catcccgaag     1260

gtggcagacc cttggggggg gtcatacatg atggagtgtc tgacaaacga cgtttatgac     1320

gccgctctga agctgattaa tgagatagaa gagatgggcg ggatggcaaa ggcagtcgca     1380

gaaggaattc caaaactgcg cattgaggaa tgtgcagccc gcagacaagc ccgaatagac     1440

agcggaagtg aagtcattgt aggagtgaat aaataccaac tggagaaaga ggacgctgtt     1500

gaggtgcttg ctattgataa cacaagcgtc cgcaatcgac agatcgagaa gcttaaaaaa     1560

attaagtcga gccgagatca ggccctggcc gagcgctgcc ttgccgcgct gacggagtgc     1620

gccgcctcag gagacgggaa tattcttgct ctggcagtgg acgctagccg cgcacgatgc     1680

acagtcggtg agattactga tgctctcaaa aaagtgttcg gggagcacaa ggctaatgat     1740

aggatggttt ccggagccta cagacaagag tttggtgagt caaaggagat cacgagtgcc     1800

attaaacgcg tccacaaatt tatggagaga gagggtcgcc ggccaaggct gctggtggct     1860

aagatgggac aggacggcca cgataggggg gctaaagtga tcgccacagg atttgccgac     1920

cttggctttg atgtcgacat cggaccactg ttccagacac caagggaggt cgcgcaacag     1980

gcagtagacg cagatgtcca tgccgtcggg gtcagcacgc tggcggctgg acataagact     2040

ctggtccccg agcttatcaa agagctgaat tcactcggga ggccagatat cctcgtgatg     2100

tgtggtggtg taattcctcc ccaggattac gagtttttgt tcgaggtggg ggtctcaaat     2160

gttttcggcc ctggcacacg tatccccaag gccgcagtgc aggtcctcga tgatatagag     2220

aagtgcctgg aaaagaagca gcaaagcgtc                                      2250


<210>  15
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  15
atgcttagag ccaagaatca gttgttcctg ttaagcccac attacctcag acaggtgaag       60

gagagttccg gctcacgcct cattcagcag cgtttactac accagcagca gccgctccac      120

cctgagtggg cagctttggc caagaaacag ttgaagggta aaaatcccga agatctcatc      180

tggcacactc ccgaaggaat ctcaattaaa cctctgtaca gtaaaagaga cacaatggac      240

cttccggagg aactcccagg cgtcaagcca tttaccaggg gcccatatcc aaccatgtat      300

accttccgtc cttggacaat aagacagtac gccggcttta gtactgtgga ggaatctaat      360

aagttttaca aagataatat caaagctggc cagcaggggc ttagtgttgc gttcgacctg      420

gccacccatc ggggctacga ctctgacaac cctcgggttc gcggcgatgt gggaatggca      480

ggtgtcgcca ttgataccgt tgaggatacc aagattctgt tcgacggcat ccccttggaa      540

aagatgagcg taagtatgac catgaatggt gctgtcattc cagtgttggc taatttcatt      600

gtaaccggag aagagcaggg agtgccaaaa gagaagctga caggcacaat acagaacgac      660

attctgaagg agttcatggt gcggaatacc tatatcttcc ccccggagcc tagtatgaag      720

atcatcgccg atatttttga gtatacagca aaacacatgc caaaatttaa ctctatttct      780

atttcaggat accatatgca ggaggccgga gccgacgcca ttcttgagct ggcttatact      840

ctggctgacg gcttggagta ctctaggact ggcctgcagg ccggcctcac aatcgacgaa      900

ttcgcacccc gactgtcctt tttttggggg attggcatga atttttacat ggagatcgca      960

aaaatgcggg cgggccgcag actgtgggcc cacctgattg agaagatgtt tcagcccaag     1020

aatagcaagt cacttcttct cagggctcat tgtcagactt caggttggtc gctgaccgag     1080

caggatccct acaacaacat tgtacgaact gccatcgagg ccatggccgc tgtgtttgga     1140

ggcacccagt cactgcatac aaatagtttt gatgaggctc tggggctccc caccgtgaaa     1200

agcgctcgaa tagcccggaa cacgcaaatc atcatccagg aggaatccgg aatacctaaa     1260

gttgccgacc catggggtgg gagctacatg atggaatgtc taaccaacga tgtgtacgat     1320

gcagcattga agcttataaa tgagatcgaa gaaatggggg gaatggcaaa agcagtggcc     1380

gaaggcattc ctaaacttcg catcgaagag tgcgctgcac ggaggcaggc ccgaatcgat     1440

tccggtagcg aggtgattgt gggagtgaat aaatatcaac tggaaaagga agatgccgtg     1500

gaggtgctgg ctattgataa cacctcagta agaaacaggc agattgaaaa attgaaaaag     1560

ataaagtcat cgcgcgatca agccctggcc gaacggtgtc tcgcggccct gactgagtgc     1620

gccgccagtg gtgatggaaa catcttggca ctggctgtcg atgctagccg ggcccgctgc     1680

accgtgggag aaatcactga cgccctgaag aaggttttcg gcgaacataa ggcaaatgac     1740

agaatggttt caggggccta taggcaggaa tttggcgaat ccaaagaaat tactagcgcc     1800

atcaagcgag tgcacaagtt catggagcgg gaaggtcgtc gcccgcgcct gcttgtcgca     1860

aaaatgggcc aggacgggca tgacagaggg gctaaagtca tcgccactgg atttgcggat     1920

ctcggtttcg acgtggatat tggacctctg ttccagacac cacgggaggt ggcccagcag     1980

gcggtggatg cagatgtgca cgcagtcggg gtctcgacac tcgccgcagg acacaaaacc     2040

ttagtccctg agctgattaa agaacttaac tcattaggcc gccctgatat cctggttatg     2100

tgcggaggcg tgatccctcc acaggattat gaatttttat tcgaagttgg ggtgtctaat     2160

gtttttggcc ccgggacacg gatcccaaag gccgcggtgc aggtcctgga tgatatcgag     2220

aaatgtttgg agaagaagca gcaaagtgtg                                      2250


<210>  16
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  16
atgctgagag cgaaaaacca gctttttctt ttgtcacctc attacctgag gcaggtcaaa       60

gagagttcgg gttccagact gatacagcag cgccttcttc atcagcagca gcccctacat      120

ccagagtggg cagctctcgc taagaaacag ctgaagggca agaaccccga agatctcatc      180

tggcacactc ctgagggcat ttctattaag cccctgtact ctaaacgaga cactatggat      240

ctccccgagg aattgccagg cgtgaaacca ttcacaaggg gcccataccc caccatgtat      300

actttccggc catggacaat ccggcagtac gccggcttct cgaccgtgga agaatccaat      360

aaattttata aggataacat aaaggcgggg cagcagggac tatccgtggc cttcgatcta      420

gctactcaca gaggctacga cagcgacaac ccaagagtta gaggggatgt tggcatggcc      480

ggggtggcaa tcgacaccgt ggaggatacg aagatcctct tcgatggaat ccccctggag      540

aagatgagtg tgtcgatgac catgaatggc gccgtgatcc ccgttctggc taatttcata      600

gtgacgggcg aagaacaggg ggtgccaaag gaaaaactga ctggaaccat tcagaacgac      660

attttaaagg agttcatggt gaggaatact tacatctttc caccagagcc tagtatgaaa      720

ataatagctg acatttttga gtacaccgct aagcatatgc ctaagtttaa ttcaatctct      780

atttcaggtt atcacatgca agaggcgggt gcagatgcaa tcctagagct ggcctataca      840

ctggctgacg gactggagta ctctcgcacg ggacttcagg ccggactcac tatcgacgaa      900

tttgctcctc ggctgagttt tttctggggg atcgggatga atttttacat ggagatcgcg      960

aaaatgcgtg ctggcaggcg cctgtgggcg cacttgattg agaaaatgtt tcagcccaaa     1020

aattccaagt ccctgctgct gagggctcat tgccaaacta gcggatggtc tcttaccgag     1080

caagatccct acaacaatat tgtgagaaca gctattgagg ccatggctgc agtgtttgga     1140

gggacacaga gtctccacac caactcattt gatgaagccc ttggattacc cactgtgaag     1200

tctgccagga tcgcaaggaa tactcagata atcattcagg aggagagcgg catcccaaag     1260

gtagctgacc cctggggggg ctcctacatg atggagtgtt tgaccaacga tgtgtacgac     1320

gccgcgctca aactcattaa tgaaattgag gaaatgggtg ggatggctaa agccgtggcc     1380

gagggcattc ctaagctcag aatagaagaa tgcgccgcca gaaggcaggc gcgcattgat     1440

agtggttcag aggttattgt gggagtaaat aagtaccagc tggagaagga agacgccgtt     1500

gaagttctgg ccatcgataa cacaagtgtg cgcaacagac agatcgaaaa acttaaaaag     1560

attaagtcga gtcgggacca ggcattggca gagagatgtt tagccgcact taccgaatgt     1620

gccgcttcag gcgacgggaa catcctcgct ctggccgtag atgcatcccg tgcgcgctgc     1680

actgtcggcg aaatcaccga cgccctgaag aaagtgtttg gggagcacaa ggcaaatgat     1740

cggatggttt ctggggctta caggcaggaa ttcggagaaa gtaaggagat cacctccgcc     1800

ataaagcgtg tccacaagtt catggaacgg gaaggccgcc gaccaagact actcgttgcc     1860

aagatgggcc aggacggaca tgacagaggt gccaaggtga tagcaacagg gtttgccgac     1920

ctgggattcg acgtggatat cggacccctc tttcaaaccc cacgggaagt tgcccaacag     1980

gccgtcgatg ctgacgtgca cgctgttgga gtgtctactc ttgctgccgg gcacaagacc     2040

cttgtgcccg agctgattaa ggagttgaac tcccttggac ggcctgacat cctggtgatg     2100

tgcgggggcg tgatccctcc tcaggactat gaattcctgt ttgaggtggg ggtatcaaac     2160

gtttttggtc cgggcactag gatcccaaag gccgcagtac aggtattgga cgacatagag     2220

aagtgcctcg aaaagaaaca acaatcagta                                      2250


<210>  17
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  17
atgttgcgcg ccaaaaatca gcttttttta ctatcacctc actacctgag acaggtgaaa       60

gagtcctccg ggagccggct cattcaacaa aggctactac atcaacaaca gcccctccac      120

cctgaatggg cagctctcgc aaagaaacag ctcaagggta aaaatcctga ggacttaatc      180

tggcatacac ctgaaggtat ttctataaag cccctgtatt ccaagcgcga tacaatggat      240

ctgccagaag agctccctgg agtgaaacct tttacccggg gtccgtatcc tactatgtat      300

acttttcgcc cttggacgat aaggcaatac gctggattct caactgtgga agaaagtaat      360

aaattttaca aggataacat taaggccggc cagcagggtc ttagtgtggc tttcgatctt      420

gccacacacc ggggttacga ttcagacaat ccacgggtgc gtggcgatgt gggcatggcg      480

ggggtcgcca tcgataccgt ggaggatacc aagatactct tcgatggcat tccattagag      540

aaaatgagtg tatctatgac gatgaacggc gccgtcatcc ccgtcttagc caattttatt      600

gtcacaggcg aggagcaagg agtgcctaaa gagaagctga caggaacaat tcaaaatgac      660

atactgaaag agtttatggt caggaacaca tacatattcc ccccagaacc gtctatgaag      720

attatagcgg atatttttga gtacactgca aagcatatgc cgaaattcaa ctctatctcg      780

atctccggct accacatgca ggaggctggc gccgacgcca tccttgagct ggcctacacc      840

ctcgcagacg ggctggagta ttcccgcact ggcctccaag ccggcttgac gatcgacgaa      900

ttcgcaccca gactgtcatt tttctggggg atcggcatga acttttatat ggagatcgca      960

aaaatgcgcg ccggacggag gctttgggca cacctcatag aaaagatgtt tcagcctaaa     1020

aattccaaat ctctgctgct cagagcccac tgtcagacga gcggatggtc cctgaccgag     1080

caggatccgt acaacaatat tgtgagaacc gccatcgagg ctatggctgc tgtgtttggg     1140

ggcactcaaa gtctccatac aaatagcttc gacgaagctc tggggcttcc tacagtgaaa     1200

tccgccagaa tcgccagaaa tacccagatt attatccagg aggaaagtgg cattccgaag     1260

gttgcagacc catggggtgg ctcctatatg atggagtgtc tgacaaatga tgtctatgac     1320

gctgccctta agctgatcaa tgaaatcgag gaaatgggcg ggatggcgaa agctgtggct     1380

gagggcatcc caaagttgag aatagaagaa tgtgcggcca ggcggcaggc tcgcatcgac     1440

tctggtagtg aggtgatcgt gggcgttaac aagtaccagc tggaaaagga agatgctgtg     1500

gaggtcctgg ccatcgacaa tacctccgtg aggaatagac agatcgaaaa gctcaagaag     1560

atcaagtcct cccgggacca agctttggcg gagcgttgtc tggctgccct cactgaatgt     1620

gcggcatcag gggacggtaa tattctggcg ctcgctgtgg acgcaagtag ggccaggtgc     1680

actgtggggg aaattaccga tgccctcaag aaggtttttg gcgaacacaa ggccaatgac     1740

cgcatggtgt caggggcata ccgccaggag ttcggcgaga gcaaggagat cacgagtgca     1800

atcaagcgcg tccacaagtt catggaacgt gaggggcgca gacccagatt actcgtcgcg     1860

aaaatgggtc aggatggcca tgaccgcggc gcgaaagtga tagctactgg atttgcagat     1920

ctggggttcg atgtcgacat tggccccctt tttcagaccc ctagggaggt cgcccagcag     1980

gccgttgacg cggacgtcca cgccgttggc gtttcaacgc tggctgccgg gcataagacc     2040

ctggtgcccg agcttattaa agagctgaat agcctgggca ggcctgacat cctcgttatg     2100

tgcggcgggg tcatcccccc gcaagactac gagttcctgt tcgaggttgg cgtctcaaac     2160

gtgttcggcc cagggacacg catccctaaa gcagcagttc aggtgctgga tgacattgag     2220

aagtgtcttg agaaaaaaca gcagtctgtg                                      2250


<210>  18
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  18
atgctgagag cgaaaaatca actcttccta ttgtctcctc attatctccg ccaggttaag       60

gagtcttccg gaagccgttt gatccagcag cggctactgc atcagcagca gcccttgcac      120

ccggagtggg cggctctcgc caaaaaacag cttaaaggta aaaatccaga ggatctcatc      180

tggcacacac cagaaggcat cagcattaag cccctgtact caaagaggga taccatggat      240

ctcccggagg agcttccagg ggtgaagcct ttcaccaggg ggccgtaccc cactatgtac      300

acctttagac catggacgat tcgtcagtat gcgggcttta gcaccgtgga agagagtaac      360

aagttttata aggacaacat caaagccgga caacagggtc tgtctgttgc tttcgacctt      420

gccacacacc ggggctatga ttctgacaac ccacgtgtgc gtggcgacgt gggtatggca      480

ggcgttgcca tcgacactgt cgaggacacc aaaattctat tcgatggaat ccccctcgaa      540

aagatgtccg tttctatgac gatgaacgga gccgtgatac ccgtgctggc caattttatt      600

gttacaggcg aggaacaagg tgtcccgaag gaaaagctga ctggaacgat tcaaaatgat      660

atactcaagg agtttatggt acgaaacact tatatttttc cacccgagcc ctctatgaaa      720

atcatcgcag acatattcga gtacacggcc aagcatatgc ccaaatttaa cagcatctca      780

attagcggat accacatgca agaggcgggc gcagacgcga ttctggagct ggcctacaca      840

ttagctgatg gcctcgagta ctcccgcacc ggcctgcagg ccggactgac tatagacgaa      900

tttgcgccta ggctctcctt tttctggggg attggaatga atttctacat ggagatagca      960

aagatgcgcg ctgggcgccg tttatgggct catctaattg aaaaaatgtt ccagcccaaa     1020

aatagtaaat ccttactgct gcgggcccac tgccagactt ctgggtggtc actgaccgag     1080

caggacccct acaataacat tgtcaggacc gccattgaag caatggctgc tgtttttggg     1140

gggacccagt ccttgcatac aaacagtttt gatgaagccc tgggactgcc aactgttaaa     1200

agcgccagaa ttgcccgtaa cacccagata atcatccagg aggagtccgg tattccaaaa     1260

gtggccgacc cctggggggg tagctatatg atggagtgtc tgaccaacga cgtctatgac     1320

gccgcactta agctaattaa cgagattgag gaaatgggtg gaatggccaa agccgtagct     1380

gaaggtatcc caaagctgcg cattgaggaa tgcgccgcta gacggcaggc gcgaatcgac     1440

tctggtagtg aggtcatcgt cggggtgaat aagtaccagt tggagaagga ggatgcagta     1500

gaggtactgg ctatagacaa cacaagtgtc cgcaaccgac agatcgagaa gctcaaaaag     1560

ataaagagct caagggatca ggccctcgcc gagcgctgtc tcgccgctct taccgagtgt     1620

gctgccagtg gtgacggaaa catattggcc ctcgccgtgg acgcttcaag ggcacggtgt     1680

acagtgggtg agattactga tgcactgaag aaggtattcg gagaacacaa ggctaacgat     1740

agaatggtat ccggggccta tcggcaggag ttcggagagt caaaggagat tactagcgca     1800

atcaagagag tgcataaatt catggagcgc gagggtagaa gaccacgact tctggtcgct     1860

aaaatgggcc aagacggtca tgatcgcggt gcgaaggtca ttgctacagg tttcgccgac     1920

ttgggctttg acgtcgacat aggcccactc ttccagaccc cccgcgaagt agcccagcag     1980

gccgtggacg ccgatgttca cgccgttgga gtgtcaacgt tagccgctgg ccacaagacg     2040

ctagtgcccg agttgattaa ggaactcaac tcactgggcc gacccgacat tctcgttatg     2100

tgcggagggg tgattccacc acaagattat gagttcctgt ttgaggtcgg agtctccaat     2160

gtatttgggc ctggaacgag gatacccaag gccgctgttc aggtgctcga cgatatcgaa     2220

aagtgcctgg agaaaaagca gcaatctgtg                                      2250


<210>  19
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  19
atgctcagag caaagaacca gctgttccta ttatcccctc actacctgcg gcaggtcaag       60

gagagttcag ggagtcgcct tatccagcag aggctgttac accagcagca gccacttcat      120

cctgagtggg ctgccctggc taagaaacaa ctgaaaggga agaaccccga ggacctgatc      180

tggcatacac ctgagggcat ctccatcaaa cctctgtact ctaaacgaga caccatggac      240

ctgccggaag agttgccagg agtgaaaccc tttacacgag ggccttatcc aaccatgtat      300

acctttaggc cttggaccat aagacagtac gccgggtttt caaccgtgga ggagtctaat      360

aagttttaca aggacaatat caaggctggc cagcagggcc tgagtgtcgc gtttgatctg      420

gccacacatc ggggctatga tagtgacaac ccaagggttc gtggcgacgt gggtatggcc      480

ggtgtggcta tagacacagt ggaggacact aagatcctgt ttgacgggat tcctcttgag      540

aagatgtccg tcagcatgac catgaatggc gccgtgattc ctgttttggc aaacttcatt      600

gtcactgggg aggaacaggg cgttcccaag gaaaagctga cagggactat ccagaatgat      660

atactgaaag agttcatggt tcggaataca tacatattcc ctcctgaacc ttccatgaag      720

atcatcgctg acattttcga atatacagca aagcacatgc caaaatttaa cagcatttcg      780

atttcaggct atcacatgca ggaggctggc gctgatgcca tcctcgaatt agcgtacact      840

ctagctgatg ggctggagta ctcaaggaca ggcctccagg ccggcctgac gattgatgag      900

ttcgctcctc gcctctcttt tttctggggc atcggtatga acttttatat ggagatcgcg      960

aagatgcggg ccggccgcag gctttgggct catctgattg aaaagatgtt tcagccaaag     1020

aatagcaaat cactgctgtt acgcgcccat tgtcagacaa gcggctggag cctgaccgag     1080

caggatcctt ataacaatat cgtacggaca gccattgaag caatggccgc agtcttcggc     1140

ggaacccaga gcctgcatac taatagcttc gatgaggctc ttggtctccc aaccgtcaag     1200

tccgcccgga tcgccaggaa cacccagatc attattcagg aggagagtgg tatccctaaa     1260

gtggctgacc cttggggcgg gagctacatg atggaatgcc tcaccaacga cgtttacgac     1320

gcagccttga aactgatcaa cgagatcgaa gagatgggcg ggatggccaa ggccgtagcc     1380

gaaggaatac ccaaactccg aatcgaagaa tgcgcggcta ggcggcaggc acggattgac     1440

tcaggcagcg aggtgatagt tggggttaac aagtaccagc tagagaagga ggacgctgta     1500

gaagttctgg caatcgacaa caccagtgtg agaaatcgtc aaatagaaaa attgaagaag     1560

ataaagtcat cccgggacca agccctggcc gagagatgtc tcgccgcatt gactgagtgt     1620

gccgcgtccg gcgacggcaa cattctagct ctggctgtcg acgcctctcg agccaggtgt     1680

acagtgggcg aaatcaccga cgctttgaag aaagtcttcg gggagcataa ggctaacgat     1740

aggatggtgt ctggagctta tcgccaggaa ttcggggagt ctaaagagat cacttctgca     1800

attaagcggg ttcacaaatt catggagaga gagggcaggc ggccacgatt attggtagcc     1860

aagatgggcc aggatggaca cgataggggc gccaaagtga ttgctacggg cttcgccgat     1920

ctgggatttg acgtggacat tgggcctttg ttccagaccc ctcgagaagt cgcccagcag     1980

gccgtcgacg cagatgttca cgccgtgggt gtgtccacgc tagccgcagg acacaagaca     2040

ttggtgccag agcttatcaa agagctgaac tccttgggca ggcccgacat attggtcatg     2100

tgtggcggcg taatcccacc tcaggattat gaattcctat ttgaggttgg ggtctcaaac     2160

gtgttcgggc cagggactag gatcccgaag gccgcagtcc aggttctgga tgacattgaa     2220

aaatgtctgg agaagaagca acagagtgtg                                      2250


<210>  20
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  20
atgcttaggg ccaagaacca gctgtttctg ctcagccctc actatttacg gcaggtcaag       60

gagagctcag gatccaggct gattcagcag cgtttgctgc accagcagca gcccctccac      120

ccggagtggg ccgcactcgc taagaaacag ctgaaaggga agaatcctga ggacttgatc      180

tggcacacac cagagggaat cagtatcaag cctctgtaca gtaagcggga cacaatggac      240

ctacctgaag aactccccgg agtgaagccg ttcaccagag gaccttaccc aaccatgtat      300

actttcagac cgtggacaat tagacagtat gctggatttt ccactgttga ggaatcaaac      360

aagttttata aggataacat caaagcgggt caacaggggc tgtctgtggc attcgattta      420

gcaacccaca ggggctacga ctcagataat ccacgagtga gaggtgatgt gggcatggca      480

ggcgtggcta ttgatacagt ggaggacaca aagatactct ttgatggaat ccctctggag      540

aagatgtccg ttagcatgac tatgaacggt gccgttattc ccgtgctagc aaacttcatc      600

gtgactgggg aagaacaggg ggttccaaag gagaaattaa ccgggaccat acagaacgac      660

attctcaagg agtttatggt gcgtaacact tacattttcc cgcctgaacc aagcatgaag      720

atcatcgccg atattttcga gtatacagcc aagcacatgc cgaagttcaa cagtatctct      780

atctctggat accatatgca ggaggctggt gcagacgcca ttctagaact agcgtataca      840

ctggccgatg gattggaata cagcagaaca ggcctgcagg ccggactgac tattgacgag      900

ttcgcccctc ggctttcctt tttctggggc atcgggatga acttctatat ggaaatcgcc      960

aaaatgaggg caggccggcg actgtgggct catctgatcg agaagatgtt tcagccaaaa     1020

aacagcaaat ctttgcttct tagggcccac tgccagactt cagggtggag cctcactgag     1080

caagacccat acaacaacat cgtcagaact gcaatcgagg ccatggctgc cgtattcggt     1140

ggcacacagt ctttgcacac taactcattc gatgaggcgc tcggcctgcc aactgtgaag     1200

tctgccagga ttgctcgaaa tacgcagatt atcattcagg aggagagcgg gatccccaag     1260

gtggccgacc catggggtgg gagttatatg atggagtgtc tgacaaatga cgtgtatgat     1320

gcggccctta agctcattaa cgagatagag gaaatgggcg gtatggccaa ggccgtcgct     1380

gagggtattc ctaagctaag gatcgaagag tgcgctgctc gcaggcaggc cagaattgat     1440

agcgggtctg aagtgatagt gggcgtgaac aagtatcagc tcgagaagga agacgctgta     1500

gaggtgctag ccattgataa cacctccgtg cgaaataggc agatcgagaa attgaagaag     1560

attaagtctt cacgggacca ggcacttgca gagcgatgtt tagcggcact gaccgaatgc     1620

gctgctagtg gtgacggtaa tattctagct ttggcagttg atgcgtctag agctaggtgt     1680

actgtgggcg aaataactga cgctctcaaa aaagtgttcg gagagcacaa ggctaacgac     1740

cggatggtgt ccggagccta tcgacaagag ttcggggagt ctaaagaaat tacaagcgcc     1800

ataaagagag tccacaagtt tatggaacga gagggtcgtc gcccgcgact gcttgtggcc     1860

aaaatgggtc aggacggaca tgaccgagga gccaaagtaa tagcgacagg cttcgcagat     1920

ctcggctttg atgtggacat tgggcctctt tttcagaccc ctcgcgaggt agcccagcaa     1980

gccgtggacg ctgatgtgca tgcagtcgga gtctccacgc tggcagccgg ccacaaaacc     2040

ttagtgcccg aattaattaa ggagctgaac agtttgggga ggccagatat tttggtcatg     2100

tgcggaggcg taattcctcc gcaagattat gaatttttgt ttgaggtagg cgtcagtaac     2160

gtgttcggac ccggaacacg cattccaaaa gcagcagtgc aggtcctcga tgatatcgag     2220

aagtgcctcg agaaaaagca gcaatcggtg                                      2250


<210>  21
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  21
atgttacgcg cgaaaaatca attatttcta ctgtcacccc attatcttcg ccaggtgaag       60

gaaagctccg ggtcaagact gatccagcaa aggctcctgc accagcagca gcccctccac      120

cccgaatggg ctgcccttgc caagaaacag ttgaagggca aaaacccgga ggacttgata      180

tggcacacac cagaagggat cagcattaag ccactgtact ccaagcgaga caccatggac      240

ctgcctgagg aactgcccgg cgtgaaacct tttacacgtg ggccctaccc tacaatgtac      300

acatttcgcc cctggacaat aagacagtac gccgggttct caaccgtgga ggagtctaac      360

aaattctata aggacaatat aaaggcagga cagcaagggc tctctgtggc attcgatctg      420

gcaacacatc gtgggtatga ctccgacaac ccacgtgtgc ggggggacgt gggtatggcc      480

ggagtcgcaa tcgatacagt cgaggataca aagatcctct tcgatggcat tccactggaa      540

aagatgagcg tgagtatgac aatgaacggg gcagtcattc ctgtgctggc caatttcatt      600

gtgacagggg aagagcaagg tgtccccaag gagaaactga ctggtacgat ccagaacgat      660

atcctgaagg agtttatggt gcggaatact tacatcttcc cccccgaacc atcaatgaag      720

atcatcgccg acattttcga gtataccgcc aagcacatgc ccaagtttaa ctcaattagc      780

attagcgggt atcatatgca ggaggccgga gctgatgcca ttttggagct ggcatatact      840

ctggccgacg gtctggagta ttcaagaaca ggcctgcagg ccggtctgac cattgatgag      900

tttgctcccc gccttagctt tttttgggga attggaatga atttctacat ggaaattgct      960

aagatgaggg ccggcagaag gctctgggca cacctcatcg aaaagatgtt tcagccaaag     1020

aattcgaagt cactcttgtt aagggcgcat tgtcagacgt ctggctggtc tctaaccgaa     1080

caagacccct ataacaacat agtcagaaca gccatcgaag caatggctgc tgtcttcggg     1140

ggcacccaga gcctgcatac caatagtttc gatgaagccc ttggactgcc taccgtgaag     1200

agcgcacgaa ttgccaggaa tacacagatt ataatccagg aggaatccgg cattcccaag     1260

gtcgccgatc cttggggcgg gagctatatg atggagtgtc tcactaatga cgtgtatgac     1320

gcagctctga agctgatcaa cgagatcgaa gagatgggcg gcatggcgaa agccgtggct     1380

gaagggatcc ccaaattacg aatcgaggag tgtgccgctc gccggcaggc ccgaatagat     1440

agcggatctg aagtcatcgt gggagtaaac aaataccagc tggaaaagga agatgccgtc     1500

gaggtgttag cgatagacaa cacttcggta aggaacaggc aaattgaaaa attgaaaaaa     1560

attaagagca gccgcgacca ggcattggct gagagatgtc tcgccgcctt gacagaatgc     1620

gctgcctcgg gtgacggaaa catcctcgcg ctggcggtgg acgcctctcg agcgcgctgt     1680

actgtgggcg agataactga cgccctgaag aaagtgttcg gcgagcacaa agctaacgac     1740

cggatggtct cgggagccta ccgtcaggag ttcggcgaga gtaaggaaat aacaagtgcc     1800

attaagcgag ttcacaaatt tatggagagg gagggacggc ggccccggct cctggtcgct     1860

aaaatgggac aggatggaca cgaccgagga gcaaaagtga ttgctactgg gtttgctgat     1920

ctaggatttg atgtggatat cggccccctg ttccagactc cccgcgaggt ggcgcaacaa     1980

gctgtggatg ccgacgtcca cgcggtgggc gtgtcaactc tggctgccgg acacaagacc     2040

ttagtgccag agctgattaa ggagctgaac tccctaggtc gcccagacat tcttgtaatg     2100

tgtggcggag tgatccctcc gcaggactat gaattcctct tcgaagttgg ggtcagcaac     2160

gtgttcgggc ctggtacccg catccccaag gcagctgtcc aagtcttgga cgatatcgag     2220

aagtgtctcg agaagaaaca acagtccgtt                                      2250


<210>  22
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  22
atgttgcgag ccaaaaatca attgtttctg ttatctccac attacctgag acaggtgaag       60

gagagttctg gtagtaggct gattcaacag aggttactcc atcagcagca acccctgcat      120

cctgagtggg cggctctcgc gaagaaacaa ctgaaaggaa aaaaccctga agatttgatt      180

tggcacactc ctgaggggat ttcaatcaag ccgctgtact ccaagcgcga cacaatggat      240

ttgcctgagg agttgcccgg cgttaagccg ttcacccgag ggccctaccc cactatgtac      300

accttccgcc cctggacgat ccggcagtat gcgggattca gtacggtgga agaaagtaac      360

aaattttata aggacaacat taaagcaggc caacagggcc taagcgtggc tttcgacctg      420

gctacccata ggggatacga ctcagacaac ccccgagtac ggggagacgt ggggatggcg      480

ggagttgcca ttgacacagt tgaagacacc aaaatcctgt ttgatggcat ccccctggag      540

aaaatgtctg tttccatgac gatgaatggt gccgtgattc ccgtgctggc aaatttcatc      600

gttacagggg aagagcaggg cgtgccaaaa gagaagctga ccggtaccat acagaatgat      660

attctgaaag agtttatggt gcggaacaca tacatcttcc cccctgagcc tagcatgaag      720

ataatagcag acatttttga gtacaccgcc aagcatatgc ctaaatttaa cagcatcagt      780

atctccggct atcacatgca ggaagccggg gcagatgcta tactggagct ggcttacact      840

ctggcagacg gactggaata ctctcgaaca ggactgcaag cgggactgac catcgatgaa      900

tttgctccac gactgtcgtt cttttgggga atcggcatga acttctatat ggagatcgcc      960

aagatgcggg caggccgtcg tttgtgggct catctgatcg agaagatgtt ccaaccaaag     1020

aattccaaaa gtttgctgct ccgggcacac tgccaaactt cagggtggag cctgacagaa     1080

caagacccct ataataacat tgttagaacg gccatagagg cgatggcagc tgtcttcggg     1140

ggcacacagt ccttgcacac aaacagcttt gacgaagcct tgggccttcc aactgtgaag     1200

tcagccagga ttgccagaaa cacccagatc atcatccaag aggaatctgg catccccaaa     1260

gtggccgacc cctggggcgg cagctatatg atggagtgtc tgaccaatga cgtgtatgac     1320

gcagcactga agctcatcaa tgaaatcgag gagatgggcg gaatggccaa ggccgttgcc     1380

gaaggaatac cgaaattgcg gatagaagaa tgtgcggccc ggagacaggc caggatcgac     1440

agcggttctg aggtgatcgt gggtgtcaat aagtatcagc tcgagaaaga agatgccgtg     1500

gaggttctgg ccattgataa tacgtctgtg cgtaatcgac agattgaaaa actcaaaaaa     1560

atcaaatcca gcagggacca agcgctggcc gagcgatgtc tggcagctct cacagaatgt     1620

gcggcttcag gggatggcaa tatcctagct ctggccgtcg atgcaagccg agcccgatgt     1680

actgtgggcg aaattactga cgcgctgaag aaggtgttcg gagagcataa ggcaaatgat     1740

cggatggtgt ccggcgctta ccgccaagag tttggcgagt caaaagagat tacgagtgcc     1800

attaagcggg tgcacaaatt catggagcgc gagggtcgca ggcccaggtt gcttgtggca     1860

aaaatggggc aagatgggca cgaccgtgga gcaaaagtga tcgccacagg attcgccgat     1920

cttggttttg acgtcgatat tgggccattg tttcagactc ctagggaagt ggcccagcaa     1980

gctgtcgacg ccgatgtgca tgccgttggg gtctccaccc tggctgccgg gcacaagaca     2040

ctggtgccag aactgattaa ggaactgaat tctctgggac gacctgacat tctggttatg     2100

tgtggtggcg ttatcccccc acaggattat gaattcctat tcgaggtagg agtgtctaat     2160

gtgttcgggc ctggtacgag aatcccaaaa gctgcagttc aagtgctgga tgacattgag     2220

aagtgtctgg aaaagaaaca acagtcagtg                                      2250


<210>  23
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  23
atgcttagag ctaaaaacca gttgttcctg ctgtcgccgc actatctaag gcaggtaaaa       60

gagtcgagcg gctctcggct gatccagcaa agactattac accagcagca accgctgcat      120

cctgagtggg ctgcactagc caagaaacag ctaaagggca agaatccaga ggacctgata      180

tggcacactc ccgaaggcat ttctattaaa cccctctata gcaagcgtga caccatggat      240

cttcctgaag aactccccgg cgtaaagccc ttcacgcggg gcccctatcc cactatgtac      300

accttccgcc cctggactat tcgtcagtac gccggtttct ccaccgtgga agaatctaat      360

aagttctaca aagacaatat caaggccggg cagcagggac tcagcgtggc ttttgatctc      420

gctacccatc gcggttacga cagtgacaac cctcgcgtga gaggtgatgt cggtatggcg      480

ggagtggcaa tagataccgt tgaagacact aagatccttt tcgatggcat tcccctggag      540

aagatgtcgg tgtccatgac gatgaatgga gcagtcatcc ctgtgttagc aaatttcata      600

gtaaccggag aggaacaggg tgtccctaag gagaagctga caggaaccat ccagaacgat      660

attctaaagg aattcatggt caggaatacc tatatctttc cgcccgaacc aagtatgaaa      720

atcatcgccg acattttcga atataccgct aaacacatgc cgaaattcaa cagcataagc      780

atttcaggct atcacatgca ggaggccgga gcagacgcaa tcttagaact ggcttacaca      840

ctggcggatg gactagaata ctctaggact ggcctgcagg ccgggctcac aattgacgaa      900

tttgctccac ggctttcttt tttctggggg atcggtatga acttctacat ggaaatagcc      960

aagatgagag ctgggagacg gctgtgggca cacctgatcg aaaaaatgtt ccagccgaaa     1020

aatagtaaaa gcctgctgct gagagctcac tgccagacga gcggctggtc tctgacagag     1080

caggaccctt acaacaacat cgtccgcacc gctattgagg ccatggccgc cgtatttggc     1140

ggaactcagt ccttgcatac caatagtttc gacgaagctc tgggattgcc caccgttaaa     1200

tccgctcgta tcgcccgcaa cacgcagata attattcagg aagagagtgg cattcctaag     1260

gttgctgatc cttggggagg gagttacatg atggaatgtt taaccaacga cgtgtatgat     1320

gccgccctca agctgatcaa tgaaatcgag gaaatgggag ggatggcaaa agcggtggca     1380

gaaggaattc ctaagctcag gatcgaggaa tgtgctgctc ggcgacaggc acgcattgac     1440

tccggaagtg aagtgatcgt tggcgtcaat aaatatcagt tggagaaaga ggacgcggtc     1500

gaagtcctcg ctattgacaa tacctccgtc cgcaacaggc agatagaaaa actcaagaaa     1560

atcaaatcga gtcgcgatca ggctctggcc gaacgttgcc tggccgctct caccgaatgt     1620

gccgcaagtg gcgacggcaa cattttagcc cttgccgttg acgccagccg agcaaggtgc     1680

acagtggggg agatcacaga tgcccttaaa aaagtgtttg gagagcataa agccaacgac     1740

agaatggttt ctggagccta tcgacaagag tttggagagt ccaaggagat caccagtgcc     1800

attaagcgcg tgcacaagtt tatggagcgc gaaggccgga gaccccggct gctagtcgcc     1860

aagatgggcc aagacggaca tgaccgaggc gctaaagtaa ttgcgaccgg atttgccgat     1920

cttggatttg atgtcgatat tggacctctg ttccagaccc ctcgcgaagt agctcagcag     1980

gccgttgatg ccgatgtgca cgccgtaggc gtatccacgc tggcagcagg acataagacc     2040

ctggttcccg agcttatcaa ggagctcaat tctctaggca gaccagacat actggttatg     2100

tgcggcggcg taatcccccc tcaagactac gagttcctgt ttgaggtggg ggtgtcaaat     2160

gtattcggcc ctgggactcg gatccccaaa gcagcagtgc aagtgctgga tgacattgaa     2220

aaatgcctcg aaaagaagca acagagtgtg                                      2250


<210>  24
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  24
atgcttcggg ctaagaacca gttgtttctc cttagtcccc attacctccg acaggtcaag       60

gaatcttcag gttctcgcct catccaacaa cgcttgctgc atcagcagca gcccctgcac      120

cccgaatggg ctgccctcgc aaagaagcaa ttaaaaggta agaacccgga ggacctgatc      180

tggcatacac ctgagggcat ttccataaag cccctctatt caaaacgcga caccatggac      240

ctacccgaag aactgccggg agtaaagcca tttactcggg ggccttaccc caccatgtat      300

acatttcgcc cctggacaat tcggcaatac gccggattct ccaccgtgga ggaatcaaat      360

aagttttata aggacaacat caaggcagga cagcagggac tttctgtagc attcgacctc      420

gccactcaca gaggctacga ctcagacaac ccacgagtca ggggcgatgt gggtatggcc      480

ggcgtggcta tagacacagt ggaggacact aagatacttt ttgacggcat ccctctggag      540

aaaatgagcg tgagcatgac tatgaatgga gccgtaatcc ctgtcttagc gaacttcatc      600

gtcaccggag aagagcaggg cgtacccaaa gaaaagctta cagggaccat ccaaaacgac      660

atcctcaaag agtttatggt taggaacacc tatatttttc cgccagagcc tagcatgaaa      720

attatcgccg acatctttga atataccgcc aagcatatgc ctaagtttaa ttctattagc      780

attagcggct accatatgca agaggccggg gctgacgcca tcctcgagct ggcctacacc      840

ctggccgatg gattagagta ctcaagaaca ggccttcaag ccggtctaac tatagatgaa      900

tttgccccta gattatcatt tttttggggc attggaatga atttttacat ggagatcgct      960

aagatgcggg ctggccggag gttgtgggcc cacctgattg agaaaatgtt tcaacctaag     1020

aacagcaaaa gccttttgct acgtgcccac tgtcagacca gtggctggtc cctaaccgag     1080

caagacccct acaacaacat agtcaggaca gctatagagg ctatggcagc agttttcggc     1140

ggaacacaat ccctgcacac taactccttc gatgaagctc tcggactgcc aacagtcaaa     1200

tccgcccgga ttgcccgaaa tacacaaatc atcattcaag aggaatccgg catccctaaa     1260

gtggccgacc cttggggcgg cagttacatg atggagtgtt tgaccaacga tgtttacgac     1320

gctgccctga aactgattaa tgagatcgag gaaatggggg ggatggccaa agcagtagcc     1380

gagggaatac ctaaactgcg gattgaagag tgcgcagcta gacgccaagc tcgtatcgat     1440

agtggatccg aggtgattgt cggagtgaat aaatatcagc ttgagaaaga ggatgctgtg     1500

gaggtgctgg ctattgataa taccagcgtg cggaacagac aaatcgaaaa gctgaagaaa     1560

ataaaatcaa gccgagacca ggcactcgcc gaacggtgcc ttgctgccct aaccgagtgc     1620

gcagccagcg gcgatggcaa catcctagct ctagccgtgg atgcatcacg cgctagatgc     1680

actgtggggg aaatcacgga cgctcttaaa aaggtctttg gggaacacaa ggcaaatgac     1740

aggatggtat caggcgccta caggcaagag ttcggggagt caaaagagat tacctcagcc     1800

ataaagcgag ttcacaaatt catggaaaga gaggggagac gaccccgact gttggtcgct     1860

aagatggggc aggacggcca tgacagggga gcaaaggtga tcgccaccgg atttgccgat     1920

ttggggttcg acgtcgacat cggacctttg ttccagacac ccagagaagt tgcccagcag     1980

gccgttgatg cggacgtcca tgccgtgggt gtgtccacac tggccgcggg acacaagacc     2040

ctggttcccg aattgatcaa agagctcaac agcctgggac ggcctgacat cctcgttatg     2100

tgtggaggcg taatcccacc ccaggattat gagttcctgt tcgaggtggg agtgtccaac     2160

gtgtttggcc ccggcacgag aattcctaaa gctgctgttc aagtgctgga tgatatcgag     2220

aaatgccttg agaagaagca acaaagcgtc                                      2250


<210>  25
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  25
atgctgcgcg caaaaaacca gcttttccta ctctcccccc attatctccg gcaggtcaaa       60

gagtcatccg gttccagact gattcagcag agactcctgc accagcaaca gccactgcat      120

ccagaatggg cagcattagc gaaaaagcag cttaagggaa agaatcccga agatctaatc      180

tggcacacac cggaaggaat cagcatcaaa cctctttaca gcaagcggga tactatggac      240

ctccccgaag agctccccgg tgtgaagcca tttaccagag gaccttatcc aactatgtac      300

acgttccggc cgtggacaat ccgacagtat gctggcttct ctaccgtgga ggagtccaac      360

aagttctaca aggacaatat taaggcgggg cagcagggac tctccgtggc attcgatctg      420

gctacccacc gagggtacga ttccgacaat ccgagggtga ggggcgacgt ggggatggca      480

ggcgttgcca ttgatacagt agaggatact aaaattttgt tcgatggcat ccccttagag      540

aagatgtccg tatccatgac catgaatggt gccgtcattc ctgttctcgc taatttcatt      600

gtaaccggag aggaacaagg tgtccctaag gagaagctga ccggtacaat acaaaatgat      660

atacttaaag agtttatggt gcgcaatacg tacattttcc caccggaacc aagcatgaag      720

atcattgccg atatctttga atataccgcc aagcatatgc cgaagttcaa ttccattagc      780

atttcaggct accatatgca ggaggcaggc gccgatgcca ttctcgaact cgcctacaca      840

ctggcggatg gcctcgagta ttcaaggacc ggtctgcaag caggcctgac aattgacgaa      900

tttgcccccc gactgtcttt tttctggggc atcgggatga atttttatat ggagattgca      960

aagatgcggg caggacgacg cttgtgggct cacctcattg aaaaaatgtt tcaaccaaag     1020

aactctaaaa gcttactgct cagggcacac tgccagactt caggctggag cctgacggag     1080

caagacccct acaataacat tgtgaggacg gctatcgagg ccatggcggc cgtgtttggg     1140

ggtacccaaa gcttgcacac taactctttc gacgaggcgc tgggtttacc gaccgtgaag     1200

agcgctagaa ttgctcggaa cacgcagatt attatccagg aagagtcagg gatcccaaag     1260

gttgccgatc cttggggggg cagttacatg atggaatgcc tgactaacga tgtttatgac     1320

gctgcactaa aattgatcaa tgaaatcgag gaaatgggag ggatggccaa ggcagtagcc     1380

gaaggcattc ccaaactacg catcgaagag tgcgccgcta ggcgacaggc taggatagat     1440

agcggttccg aggttattgt cggtgtcaat aaatatcagc tggagaagga agatgccgtg     1500

gaggttctgg ctattgataa cacctcagtg aggaatagac agattgaaaa actgaaaaag     1560

atcaagtcca gccgggacca ggcactggca gaacgatgcc ttgccgcgct gacagagtgc     1620

gcagcttcgg gggatggtaa tattctcgcg ctggccgtgg acgcaagtcg ggctaggtgt     1680

acagttggag aaataaccga cgctctcaaa aaagtctttg gcgagcacaa agcaaacgac     1740

cgaatggtga gtggtgcata tcgtcaggag ttcggagaaa gcaaggagat tacgtcagct     1800

atcaagagag tgcacaaatt tatggagaga gaggggaggc gtccacgctt acttgtggcc     1860

aagatggggc aggacggcca cgataggggc gctaaagtga tcgccactgg attcgcggac     1920

ctgggcttcg acgtggacat tgggccatta ttccagacac cccgcgaagt ggctcaacag     1980

gcggtggacg cggacgttca cgccgtagga gtatcaaccc tagccgcggg gcacaaaacc     2040

ttggtgccgg agcttattaa ggagctcaac agcctcggca gaccagacat ccttgtgatg     2100

tgtgggggtg ttatccctcc gcaggattac gaatttctct tcgaggttgg ggtgagcaat     2160

gtgtttggac caggtacgag aatccccaaa gcggccgtcc aagtccttga cgatattgaa     2220

aaatgtttag aaaaaaagca acagtcagtt                                      2250


<210>  26
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  26
atgctgcgcg ccaagaatca gttgtttttg ttgagtccac actacctgag acaggtaaag       60

gagagctccg gcagcaggtt gatccaacag cgcctgttac accagcagca acccctgcac      120

ccggaatggg ctgcacttgc caagaaacag ctgaaaggga aaaaccccga ggatctgatt      180

tggcacacgc cagaaggtat cagtattaag ccactgtata gtaagcgaga cacaatggac      240

cttccggaag agctcccagg ggtgaaacct tttacgcgtg gaccttaccc tactatgtat      300

acatttcggc cttggaccat ccgccagtat gccggattct ccactgtaga agagagcaat      360

aagttctata aagataatat caaggcagga cagcaaggtt tgagcgtggc ctttgattta      420

gccacccaca gaggatatga tagtgataat ccacgggtta ggggtgacgt tggaatggcc      480

ggagtcgcaa tcgatacagt cgaggataca aagatcctgt tcgacggcat tcctttagaa      540

aaaatgagcg tcagtatgac catgaatggg gccgttattc ctgtcctcgc caacttcatt      600

gtaaccggag aagagcaggg cgttcctaaa gagaaattga cggggacgat tcagaatgac      660

attttaaagg agtttatggt taggaacact tacatattcc ctcccgagcc atccatgaag      720

ataattgcag atatcttcga gtacaccgcc aagcatatgc ccaaattcaa ttctatttcc      780

ataagcggct atcatatgca ggaggcaggg gccgatgcta tcctggagtt agcttatacc      840

ctcgccgacg ggctggaata ttctcgtaca ggcctgcagg cgggtctgac tattgacgag      900

ttcgctcctc gccttagctt tttttggggg attggtatga atttctacat ggaaatagct      960

aaaatgcgcg ccggcaggag actgtgggcc catctgatcg agaagatgtt ccagcccaag     1020

aatagcaaat ccttactgtt gagagctcac tgccaaacct caggatggtc cctgacagaa     1080

caggatcctt ataataacat cgttcgcacc gccattgagg ccatggcagc cgtctttggt     1140

ggaactcaga gcctgcatac caacagtttc gacgaggcgc ttgggctgcc gacagtcaag     1200

agtgcccgaa tcgcaagaaa tacccagatt attattcagg aggaaagtgg catccccaaa     1260

gtcgctgatc cctggggagg gtcttacatg atggagtgtc taactaatga cgtttatgat     1320

gccgccttga aactgatcaa tgagatagag gagatgggcg gaatggccaa ggccgttgca     1380

gagggcattc caaaattacg catcgaggag tgcgccgcaa ggcgtcaagc ccgcatcgat     1440

tcaggaagtg aggtcatagt gggtgtcaac aaataccagc ttgaaaagga ggacgccgtg     1500

gaggtgcttg caatcgataa cactagcgtc agaaatcgac aaatagagaa gcttaaaaag     1560

atcaaaagct cacgggatca agctcttgct gagagatgcc tcgcagccct caccgagtgt     1620

gccgcttccg gggatggcaa catactggcg ctcgccgtgg atgcatctag ggctaggtgt     1680

acggtgggtg agattactga tgccctgaag aaggtttttg gagagcataa ggcaaatgac     1740

aggatggtta gtggagcata tcgtcaagag tttggcgaga gcaaggagat tactagcgcc     1800

ataaaacggg tgcacaaatt catggaacga gagggcaggc ggcctaggct tctggtcgct     1860

aaaatgggac aagatggaca tgaccggggt gctaaagtga tcgccacagg ctttgctgac     1920

ttggggttcg acgtcgacat aggaccactg ttccaaaccc cccgggaagt cgcgcagcag     1980

gcggtcgacg ctgatgtcca cgctgttggt gtgagtaccc tcgcagccgg acacaagaca     2040

cttgtgcctg agcttatcaa agagttaaat tccctaggcc ggccggatat actcgtgatg     2100

tgcggggggg ttatcccacc ccaggattat gagtttctgt tcgaggtggg cgtgtctaac     2160

gtattcgggc ctggcaccag aattcccaaa gccgcagttc aggttctaga cgatatcgag     2220

aagtgcctgg agaaaaagca acaatcagtc                                      2250


<210>  27
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  27
atgcttaggg ccaagaatca actgttcctt cttagcccgc attaccttcg ccaggttaag       60

gagtctagtg gatccaggct aatccagcag cggctgctac accaacaaca gcctctgcac      120

ccagagtggg ctgccctcgc caaaaagcag ctgaagggaa aaaacccaga ggatctcatt      180

tggcataccc ctgagggaat ttctattaag ccgctctata gtaaaaggga cactatggat      240

ctgccggagg agctccctgg agtgaaaccc tttaccaggg gcccataccc gacgatgtat      300

acttttcggc cttggactat tcggcagtat gccggattca gtactgtgga ggagtcaaac      360

aaattctaca aggacaatat taaagccggt cagcagggtc tgtccgttgc tttcgaccta      420

gctactcata gggggtatga tagtgacaat cctcgcgttc gcggagacgt cggtatggcc      480

ggggtggcta ttgacaccgt cgaggatacc aagatcctgt ttgacggcat cccactagaa      540

aagatgagcg tgagtatgac catgaacggc gcggtgatcc ccgttctggc aaactttatt      600

gttacgggag aagagcaagg agtacccaaa gagaaactga caggaaccat tcagaatgac      660

attctgaaag agtttatggt ccgaaatact tacatcttcc cacctgagcc ttctatgaaa      720

ataatcgcag acattttcga atacacagcg aagcacatgc caaagtttaa ctcaattagc      780

attagcgggt accatatgca ggaagccggt gctgatgcca ttctagaact tgcctacact      840

ctggcagatg gcctagagta ctcgcggaca ggtctgcagg caggcctgac aatcgatgaa      900

ttcgcccctc gcctgtcttt cttctgggga attgggatga atttttatat ggaaatcgct      960

aaaatgcgag ccggacggag gctgtgggca catcttatcg aaaagatgtt ccaacccaag     1020

aatagcaaat ctctgctgct gcgggcccat tgccaaacct ctggatggtc cctgaccgag     1080

caggatccct ataataatat tgtacgtacg gccatagaag caatggctgc agtctttggc     1140

ggcacacaga gcctccacac taacagcttc gatgaagcct tgggccttcc gaccgttaag     1200

tcagctagga tcgcgcgtaa tacccaaatt atcatccagg aagaaagcgg gattcccaag     1260

gttgccgatc cctggggggg atcttacatg atggagtgcc ttacaaacga cgtatacgat     1320

gccgcgctga aactcattaa tgaaattgag gagatgggcg ggatggctaa ggccgtagcc     1380

gaaggcatcc ctaagcttag aatcgaagag tgtgctgcaa gacggcaggc taggattgac     1440

tcgggctccg aggtcatcgt cggcgtgaac aagtaccaac tggaaaagga agatgcggtc     1500

gaggtgctgg cgatcgataa tacctcagtc aggaacagac aaattgagaa attaaagaaa     1560

atcaaaagca gtcgcgacca ggccttggct gagcggtgtc tcgctgccct cacagagtgc     1620

gccgcaagcg gcgatggcaa catactagcc ctcgctgttg atgcatccag ggcgcggtgc     1680

accgtgggag agataactga cgccctcaaa aaggtattcg gggaacataa ggctaacgac     1740

agaatggtga gtggagctta ccgccaggag tttggtgaga gtaaggagat aacatcagcc     1800

ataaagagag tgcacaagtt catggagaga gagggccggc gacccagact gctcgtggcc     1860

aagatgggtc aagacggaca tgaccggggc gccaaggtga tcgccaccgg gttcgcagac     1920

ctcgggtttg atgtcgatat cggaccgttg ttccagaccc cacgggaggt cgcccaacag     1980

gccgtggatg cggacgtgca tgcagtagga gtgagtaccc tcgccgccgg gcacaagaca     2040

ttagtccccg agcttataaa ggaactcaat tcactcggga ggcctgacat actcgtgatg     2100

tgcggaggcg tgattcctcc acaggactac gaattcttgt ttgaggtcgg ggtgtccaat     2160

gtctttggcc ctggcacgcg tattcctaaa gcggcagttc aggtgctcga cgatatagag     2220

aagtgcctgg agaagaagca gcagtctgtc                                      2250


<210>  28
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  28
atgctcaggg ctaaaaatca actttttctg ctctcgcccc actaccttcg ccaggtgaag       60

gagtccagcg gcagtagact tatccagcag cgtctgttgc atcagcaaca gccactgcac      120

cctgagtggg cagcgctggc taagaagcaa ctcaagggca agaaccctga ggatctcatc      180

tggcacacac cggaggggat tagtatcaaa cccttgtact cgaagcggga taccatggat      240

ctgcctgaag aattgccggg agtcaagccc ttcacaagag gcccttatcc caccatgtac      300

acatttaggc cctggaccat ccgccaatat gctggcttca gtactgtgga ggaatcaaat      360

aagttttata aggacaatat caaagccggc caacaaggct tgtctgtggc atttgatctt      420

gctacgcacc ggggctacga ttccgataac ccccgcgtgc gcggagacgt cggcatggca      480

ggcgtggcca tcgacactgt ggaggacact aaaattttat ttgacggtat tccactcgaa      540

aaaatgtccg tgagtatgac catgaacggt gccgtgattc ctgtactggc caatttcata      600

gtgactggtg aggaacaggg agttcctaaa gagaagctga ccggtactat ccaaaatgat      660

attcttaagg agtttatggt aagaaatact tacatctttc ccccagagcc ctctatgaaa      720

atcatagctg acatattcga atacaccgca aaacacatgc caaaattcaa tagcattagt      780

attagtgggt accacatgca ggaagctgga gctgacgcga tcctggaact ggcctacacc      840

ctggcagatg ggctagagta cagcagaacc gggctacagg ctggtctcac aatcgacgag      900

tttgctcccc ggttaagttt tttctggggc atcggtatga acttttacat ggaaattgcc      960

aagatgcggg caggaaggcg tctttgggct catctgatag aaaaaatgtt tcagcccaaa     1020

aacagtaaat cgttgttgct ccgagcacac tgccagacca gcggttggag cctgacggag     1080

caagatcctt acaacaatat tgttcggact gctatagaag ccatggctgc cgtatttggc     1140

gggacacaga gcctccacac taattctttc gacgaggcct tggggttgcc taccgtgaag     1200

agcgctcgta tcgcgaggaa tacacaaata attattcagg aagaatcagg cattccaaaa     1260

gtggcagacc cgtggggagg aagttacatg atggagtgtc tcactaatga tgtgtacgat     1320

gccgccctga agctgattaa tgaaattgaa gagatgggag ggatggctaa ggcagtggcc     1380

gaaggtattc ccaagctccg gattgaagaa tgtgcagcca ggcggcaggc ccgtatagac     1440

tcaggctccg aggtgatagt tggagtaaat aaatatcagc tggagaagga ggatgcggtc     1500

gaagtcttgg ccatcgacaa cacatccgtg aggaatcgcc agattgaaaa gcttaagaag     1560

atcaagtcaa gcagagacca ggccctcgca gaaaggtgcc tggctgctct gaccgagtgt     1620

gccgctagcg gagacggcaa tatcctagcc ctcgccgtgg atgcctctag agctcgatgc     1680

acagtgggcg aaattacaga tgccctgaaa aaggtctttg gagagcacaa ggcaaatgac     1740

agaatggtct caggcgcgta cagacaggag ttcggggaat caaaggagat cacaagtgca     1800

attaagcggg tccacaagtt catggagcgg gaagggcgga gaccccggct tctggtcgca     1860

aagatgggac aggatgggca tgacagaggt gccaaagtga tcgccacagg atttgccgat     1920

ttgggattcg acgtggatat aggtccctta tttcagaccc cgcgtgaagt agcgcaacag     1980

gcagtggacg cagacgtcca cgccgtcggg gtgagtaccc tggcggcggg acacaaaact     2040

ctagtccccg agctcattaa agagctcaac tctctgggca ggcccgatat cctagtaatg     2100

tgtggggggg ttattccacc ccaggactac gagtttctat ttgaagtggg agtgtccaac     2160

gttttcggcc ctggcacaag aattccaaag gccgccgtgc aagtgctcga tgatatcgag     2220

aagtgcttgg agaagaaaca gcagtctgtt                                      2250


<210>  29
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  29
atgttgagag ccaaaaacca gctcttcctg ctgagccctc actacctcag gcaggttaaa       60

gaaagctctg gctcacgtct aatccagcaa cgcctgctcc accagcagca acccctgcat      120

ccagagtggg ccgctttagc caagaaacag ctgaaaggta agaatcctga ggatcttatt      180

tggcatactc ctgagggtat cagcatcaaa ccactgtatt caaagcggga taccatggac      240

ctgcccgagg aacttccggg ggtgaagcct ttcacacggg ggccctaccc aaccatgtat      300

acattccgac cttggacaat ccgccagtat gcggggtttt ctactgtgga agaatctaac      360

aagttctaca aggacaacat taaagctgga cagcagggtc tctccgtcgc ctttgacttg      420

gccacacata gggggtacga ctctgacaac cctagggtcc ggggcgatgt gggtatggca      480

ggcgtggcaa ttgacaccgt cgaggacact aaaatcctct ttgacggcat ccccttggaa      540

aagatgtctg tatcgatgac catgaatggc gcagttatcc ctgtgttggc caactttatc      600

gtaactgggg aagagcaggg tgtcccaaaa gaaaagttaa caggcaccat ccagaatgac      660

atcctcaaag agtttatggt ccggaataca tatatctttc caccggagcc gtccatgaag      720

attattgccg atattttcga gtatactgcc aaacatatgc ccaagttcaa tagcatctct      780

attagcggtt atcacatgca ggaggccggc gcagacgcca tattagaact ggcttacaca      840

ttggctgatg gcctggaata tagtcggacc ggccttcagg ctggtcttac catcgatgag      900

ttcgcaccac gcttaagttt cttctgggga attggaatga atttctatat ggaaatcgcg      960

aaaatgcgtg caggtcgccg gctctgggct catctgatcg agaagatgtt tcaacctaag     1020

aattccaaga gcctgctgct ccgagctcat tgtcagacca gtggttggag cctaaccgag     1080

caagaccctt acaacaatat cgtgcggacc gccattgaag ccatggcagc tgtttttggt     1140

ggcacccagt ctttgcatac caactcgttc gatgaagcgc ttggactacc aaccgtgaag     1200

tctgcccgga tagctcgaaa cactcagatt attatccagg aggagtcggg gatacccaag     1260

gtcgctgatc cttggggcgg tagctatatg atggagtgtt tgacaaatga cgtgtacgac     1320

gcagccctca agcttattaa cgaaattgag gaaatgggtg ggatggcaaa agctgttgcc     1380

gagggaatcc ccaagctgag aatcgaggag tgtgccgcac ggaggcaggc tcgtatagac     1440

agcggtagcg aggttatcgt gggagtgaat aagtaccaac ttgagaagga agatgctgtc     1500

gaggttcttg ctattgacaa caccagtgtg cgcaatcgcc agatagagaa actgaagaaa     1560

atcaagagct caagagacca ggcactagcc gagcggtgcc tggccgcatt gacggagtgc     1620

gccgcatccg gcgatggcaa tatactcgcc ttggctgtag acgcctcacg cgcccgctgt     1680

acagtcggtg agataaccga tgcactcaaa aaggttttcg gcgaacataa ggccaacgac     1740

cgaatggtgt ctggagccta tcggcaggaa tttggggagt ctaaggaaat cacatctgcg     1800

atcaagcggg tgcacaagtt tatggaaaga gaaggacgcc ggccaagact cctggtcgcc     1860

aaaatgggcc aggatgggca tgatcggggg gcaaaagtta ttgccaccgg atttgctgat     1920

ttgggatttg atgtcgatat tggcccactc ttccagactc cacgcgaggt ggcccagcag     1980

gctgtggacg ctgatgtcca tgctgtcggt gtgagtactt tggcagccgg ccataagacc     2040

cttgtcccgg agctcatcaa ggagttgaat tccttaggtc gcccggatat tttggttatg     2100

tgtggaggcg taatacctcc ccaggactac gaatttctgt ttgaggtcgg tgtgagtaat     2160

gtattcggtc cgggaactag gatcccaaag gctgctgtgc aggtcctgga cgatatcgag     2220

aagtgccttg agaagaagca gcagtctgtt                                      2250


<210>  30
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  30
atgcttcgcg cgaagaatca gttatttctg ctgagccccc actacctgcg gcaggtgaag       60

gagtcctcag gaagtcgcct gattcagcag agactgttgc accagcagca gcccttgcac      120

cccgaatggg ccgcacttgc taagaagcag ttaaagggta aaaaccctga agatttaatt      180

tggcacaccc cagagggcat ttccatcaaa ccattgtatt ctaagcggga tacaatggat      240

ctaccagagg aactccccgg ggtcaagcca tttactaggg gaccataccc tacgatgtac      300

acatttcgac catggactat ccgccagtac gcagggtttt ccaccgttga ggagagcaat      360

aaattttaca aggacaatat aaaagccgga cagcagggac tgagtgtggc atttgatctg      420

gctacccacc ggggctatga ttcagacaac ccaagagtga gaggcgatgt gggcatggcc      480

ggcgtggcca tcgatacggt ggaggacact aagattcttt ttgacgggat tcccctggaa      540

aagatgagtg tgtccatgac catgaacggc gctgtgatac ccgttcttgc taattttatc      600

gtgactggcg aagagcaagg cgtgcctaaa gagaagctca cgggcaccat ccaaaatgac      660

attctcaaag agttcatggt gcggaacaca tatattttcc cacccgagcc ttcaatgaaa      720

atcattgccg acattttcga gtataccgca aagcacatgc ctaagtttaa ctccatatct      780

atttctggct accacatgca agaggccggc gctgacgcga tcttagagct tgcatacaca      840

cttgccgatg gtttggaata cagccgcacg gggttgcagg ccggattaac tatcgatgaa      900

ttcgctccaa ggctgtcatt tttctggggg ataggaatga atttttatat ggaaatagca      960

aaaatgcgag caggccgccg cctctgggcc caccttatag aaaagatgtt tcagcccaaa     1020

aactcaaagt cattactcct ccgtgcccat tgccaaacat ccgggtggtc attgaccgaa     1080

caggaccctt ataacaacat cgtgcgtaca gctatcgagg ccatggctgc cgtcttcgga     1140

gggacacagt ctttgcacac aaacagcttt gacgaggctt tgggactgcc taccgtgaaa     1200

tctgcacgga tcgcacggaa cacacagatc atcatccagg aggaatctgg cattccaaag     1260

gtggccgatc catggggggg gagttacatg atggagtgtc tgactaacga cgtctacgat     1320

gccgctctaa agctgatcaa tgaaattgag gaaatgggcg gtatggccaa ggccgtggcc     1380

gaaggcatcc ccaaattgag gattgaggag tgtgctgccc gaaggcaggc aagaattgat     1440

tcagggtctg aagtgatagt tggggtcaac aagtatcaac tggaaaagga agacgcggta     1500

gaagtgctgg ctatagacaa cacctctgtt aggaacagac aaattgagaa gctgaaaaaa     1560

atcaagtcat cccgggacca ggctctggct gaacgatgcc tcgccgctct cactgagtgc     1620

gccgcatccg gggacggcaa tatactggcc ctcgccgtgg acgccagtag agctcgttgc     1680

actgtcggcg agataaccga cgcacttaaa aaggtttttg gggaacataa ggccaacgac     1740

agaatggtgt ctggagcgta ccggcaggaa tttggggagt caaaagagat cacctccgcc     1800

atcaaaaggg tccataagtt catggagcgc gaaggcagac ggccaagact cctcgtggct     1860

aagatgggtc aggatggaca cgaccgggga gcgaaggtta tagcaacagg ctttgctgat     1920

ctaggctttg atgtggatat aggaccgctt ttccagaccc ctagagaagt cgcacagcag     1980

gctgtggacg ccgacgttca cgccgtgggc gtgtctacgc tcgcagctgg tcacaagact     2040

ctggtacccg aactgattaa ggagctaaat tcattaggaa ggccagatat tctggtgatg     2100

tgtggcggcg tgatcccacc gcaggactac gaattcctgt tcgaggttgg agtaagtaat     2160

gtattcggac ccggaaccag gataccgaag gccgcagtgc aggtactgga cgacattgag     2220

aagtgcctcg aaaagaagca gcagtcagtg                                      2250


<210>  31
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  31
atgctgcggg caaaaaatca gctctttttg ctctcacctc actatttgcg ccaggtcaag       60

gagtctagcg gatcaaggct gattcagcag cggctgttgc atcagcagca gcctctacat      120

cccgaatggg ctgccctggc taagaagcag ctcaaaggca agaaccctga ggatttgatt      180

tggcacaccc ccgaggggat atctattaag ccactataca gtaagcggga cacaatggat      240

ctgcccgagg agctccctgg agtcaagcct tttacccgtg gaccgtaccc aactatgtac      300

actttccggc cctggacaat tcgtcaatac gcaggtttct caaccgtcga ggaatcaaat      360

aagttttaca aggataatat aaaggctgga cagcagggat tgtctgtcgc cttcgacctc      420

gccactcata gagggtacga ctccgataac ccacgtgtgc gtggcgacgt cgggatggcc      480

ggtgtggcaa tagatacagt ggaagataca aagatcctgt ttgatggcat tcctctggaa      540

aagatgagcg tgagcatgac catgaatggt gccgtcattc ccgtgctcgc gaattttatc      600

gttactggag aagagcaggg agttccaaaa gaaaagttga ctggcaccat ccagaacgac      660

atactgaagg agtttatggt gaggaatact tatatatttc cacccgagcc cagcatgaag      720

attattgcag atattttcga gtacaccgct aagcatatgc ccaagtttaa cagcatcagc      780

ataagtggat accacatgca agaggcgggt gccgacgcca ttcttgagct ggcctatacg      840

ttagctgatg gtttggaata tagtcgaact ggattgcagg caggcttgac tatcgacgag      900

tttgccccac ggctttcatt cttttggggt ataggaatga acttctacat ggaaatcgct      960

aaaatgcgcg ccgggaggcg gctgtgggct catttgattg agaagatgtt tcagcctaag     1020

aacagcaaat cgctgctgct gcgcgcacac tgtcagacga gcgggtggtc actaacagag     1080

caagatcctt ataacaacat cgtcagaacg gcaatagaag ccatggccgc cgtgtttgga     1140

ggaacccagt ccctccatac caactccttt gacgaggctc ttggcctgcc cactgtgaaa     1200

tctgcgagga ttgcccggaa tacccagatc atcatccagg aggaaagtgg aatcccaaag     1260

gttgctgacc cctggggagg ttcttacatg atggagtgtt taactaacga cgtatacgat     1320

gccgctctga aacttatcaa tgagatagag gaaatgggag gcatggcgaa agcggtggcc     1380

gaagggatcc ccaagttacg tatcgaagag tgtgctgcga gaagacaggc ccgcatcgat     1440

agcgggtcag aagtcattgt gggggtcaac aaataccagc tggaaaagga agatgctgtg     1500

gaagtcctgg cgattgataa tacatctgtg cggaataggc agatagaaaa gcttaagaag     1560

atcaagtcga gccgagatca ggccctagca gaacgctgtc tggctgccct gacggagtgt     1620

gctgcgagcg gcgatggaaa tatcctggca ctggccgtcg acgccagccg tgccaggtgc     1680

accgtgggtg agataaccga cgcccttaag aaagttttcg gcgaacataa agccaacgat     1740

aggatggtat ccggcgctta tagacaagag tttggcgaat ctaaggagat cacaagtgcg     1800

attaagaggg tacacaaatt tatggaaaga gaaggcagac gtccgcggct tctagtggcc     1860

aaaatgggcc aagatgggca tgatcgaggc gctaaggtta ttgctacagg gtttgccgat     1920

ctgggtttcg atgttgatat tgggcccctg tttcaaacac ccagagaagt ggctcaacag     1980

gccgtggacg ccgacgtgca cgccgtgggg gtcagcacac tggccgccgg ccacaagacc     2040

ctggttcccg agctgatcaa ggaactgaac tctcttggac gcccagatat cctcgtgatg     2100

tgtggtggag tcatcccccc tcaggattac gaattcctgt ttgaggttgg cgtgtcaaac     2160

gtttttggtc ctggtacgcg catcccgaaa gcagcagtgc aagtgctgga tgatatcgag     2220

aagtgcttgg aaaaaaaaca gcagagtgtc                                      2250


<210>  32
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  32
atgctgcgcg caaaaaatca gctcttcctc cttagtcccc attacctgcg gcaggtgaag       60

gagagtagcg ggagccggct gatccaacag cgattgctgc atcagcagca gcctctgcac      120

ccagaatggg ccgccctcgc caagaaacag cttaagggaa agaaccctga ggacctgatc      180

tggcacacac ccgagggcat tagtatcaag cccctgtact cgaaaaggga tactatggac      240

ctgccggaag agttgccagg cgttaagccg tttactagag ggccgtatcc taccatgtac      300

acttttcgac catggaccat acggcaatat gcaggctttt ctactgtcga ggagagcaat      360

aagttctata aagacaatat caaggccggc cagcagggcc ttagcgtggc cttcgatctg      420

gctacccata gagggtacga tagtgacaat ccacgggtgc gcggcgacgt cggcatggct      480

ggtgttgcca tagacacagt ggaggacaca aaaatcctgt tcgatgggat ccccctggag      540

aagatgagcg tctccatgac aatgaacggc gcagtcattc ccgtgctggc gaacttcata      600

gtgactgggg aggaacaggg cgtgcctaag gagaagttga ctggcaccat ccagaatgat      660

attctgaaag aatttatggt acgcaataca tacatttttc ctcccgaacc cagcatgaaa      720

ataatagcag acatttttga atatactgca aagcatatgc ctaagttcaa ctccatttcc      780

atctctggat accatatgca ggaggccgga gcagacgcca tactggagtt ggcctatact      840

ctggcagatg ggttggagta cagcaggacg gggctgcagg ccggcctcac cattgatgag      900

ttcgccccac ggctaagctt cttctggggc attggcatga atttttacat ggagatcgca      960

aaaatgcgcg cggggagacg gctgtgggca cacttaattg aaaaaatgtt ccagcccaag     1020

aattcaaagt ctctcctgtt gcgcgcgcat tgccagacct ctgggtggtc actgactgag     1080

caagatccat acaataacat cgtgcggact gcaatagaag ctatggccgc cgtttttgga     1140

gggactcagt cactgcatac caacagcttc gatgaggccc tgggactgcc aacggtcaaa     1200

tcagcacgca tcgctcggaa tacccagatc atcatccaag aggagtcagg tatccccaag     1260

gtggctgacc catggggtgg gagttatatg atggagtgcc tgaccaacga cgtgtatgat     1320

gcggccctga agcttatcaa tgaaatagag gaaatgggag gaatggcgaa ggcagtcgct     1380

gagggtatac ccaagctgcg gatcgaggag tgcgccgcga ggaggcaggc tcgcattgac     1440

tctggaagcg aagtaatagt tggagtcaac aaataccaac tggagaaaga ggatgccgtg     1500

gaagtcctcg ccatcgacaa tacatccgtt cggaatcggc agattgagaa actgaaaaag     1560

atcaagagta gtagggacca ggctttagcg gaacggtgct tggctgcgct gaccgagtgc     1620

gcggccagtg gtgatggtaa catcctggca ctggccgtgg acgcgtcacg cgctaggtgt     1680

acagttggcg agattaccga cgcgctaaaa aaagtgttcg gagagcataa agctaacgat     1740

cgaatggtgt ccggagccta tagacaggag ttcggtgaaa gcaaggaaat aacatctgct     1800

attaagcggg tgcataaatt tatggagaga gagggtaggc gccctaggct tctggttgct     1860

aaaatggggc aggacggcca cgacaggggg gccaaagtaa tcgcgaccgg ttttgctgac     1920

ctcggtttcg acgtcgacat tgggccactc ttccagactc cacgggaggt ggcacagcag     1980

gctgtggatg ccgacgttca cgccgtaggg gtctccaccc ttgccgcagg ccataaaacg     2040

ctggtgcctg aactgattaa ggaattgaac agcttgggaa gaccagacat cctcgtgatg     2100

tgtggcggag tgattccacc tcaggactat gagttcctct tcgaggtcgg cgtcagcaac     2160

gtcttcggtc caggaactcg catcccaaag gcagcagtcc aggtgctgga tgatattgag     2220

aaatgtcttg agaagaagca gcaaagtgta                                      2250


<210>  33
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  33
atgttacgcg ctaaaaacca gctctttctc ctgagtcctc attacctcag acaagtaaaa       60

gagagctctg gatccagatt gattcagcag aggttgctcc atcagcagca gcctctgcac      120

ccagaatggg cagctctcgc aaagaaacaa ctgaagggca aaaaccctga agacctcatc      180

tggcatacac cagaaggcat ttcaatcaag cctctgtata gtaagcgcga tacaatggac      240

ctacccgagg agctacccgg tgtgaaacca ttcacgcggg gtccataccc cacgatgtat      300

actttcaggc cttggaccat ccggcaatac gcaggcttct ctaccgtcga agagagcaat      360

aagttctaca aagataacat taaggcagga cagcagggcc tgtcggtggc cttcgacctg      420

gctacccaca gaggctatga ctccgataac ccgcgggtgc gcggggacgt cggtatggcg      480

ggagtggcca ttgacaccgt ggaggatact aagatcctct tcgacgggat tcccctcgaa      540

aaaatgtcag tgtcaatgac aatgaatgga gcagtcatac cagtcctggc taatttcatt      600

gtgactggtg aggaacaggg tgtgcccaag gagaagctga ccggtactat ccagaatgac      660

attctgaaag aattcatggt aaggaataca tacattttcc ccccggagcc atccatgaag      720

attatagccg atattttcga atacacggct aagcatatgc ccaagtttaa cagcatctcg      780

attagtggtt atcatatgca ggaagctggg gccgatgcca tcttggaact ggcttacact      840

ctcgccgacg gtctggagta cagccgtacc ggcctgcagg caggcctcac aatagacgaa      900

tttgctcccc ggctgtcctt cttctggggc atcgggatga atttctacat ggaaattgcg      960

aagatgagag ccggtaggag gctttgggct catctgattg agaagatgtt ccagccaaag     1020

aacagtaaga gcctgctgct ccgggctcac tgccagactt ccggttggag tcttacggag     1080

caggatcctt acaataacat agtccgtacc gcaatcgagg cgatggctgc cgtcttcggc     1140

ggtacacaaa gtctccacac taatagcttc gatgaggcac ttggcctacc cacggtaaag     1200

tcagctagga tcgcacgcaa tactcaaatc attatccaag aggagtctgg aattccaaaa     1260

gttgccgacc catggggagg ctcctacatg atggagtgcc tgaccaacga cgtctacgat     1320

gccgcgctga agcttatcaa cgagattgag gagatggggg gcatggctaa ggcggtggca     1380

gagggaattc ctaagctgag gatcgaagag tgtgccgccc gcaggcaggc gcgcatcgat     1440

tccgggtccg aggtgattgt gggagtgaac aagtaccagc tggaaaagga ggacgccgtg     1500

gaggtactgg ctatcgataa cactagcgtg cgtaaccgtc agattgagaa gctgaagaaa     1560

attaaatcct cgcgtgatca agcccttgca gaaaggtgtc tcgctgcctt gacagagtgc     1620

gcagcttccg gagacggaaa tatccttgct cttgccgtgg acgcgtcaag ggcaagatgc     1680

acagtaggcg agatcacgga cgcactgaaa aaggtgtttg gggaacacaa ggctaacgac     1740

aggatggtga gcggcgccta ccgacaggag ttcggagagt ccaaggaaat cacgagtgcc     1800

atcaagcggg ttcacaaatt tatggaacgg gaggggagaa ggcccagact gctagtggcc     1860

aagatgggcc aggatggaca tgatcgagga gctaaagtca tcgcaaccgg gttcgcagac     1920

ctcgggttcg acgtagacat tgggcctctg ttccagaccc ccagagaagt ggcccagcag     1980

gcggtcgatg cagacgtaca cgctgttgga gtttcaacac tggcggctgg acacaagacc     2040

ttggtgccgg aactcatcaa agagctgaat agcctggggc gacccgatat cctagtcatg     2100

tgcggggggg tgatcccgcc ccaggattat gaattcctct tcgaggtggg cgtttccaat     2160

gtgttcgggc ctggcacgag aattcctaag gccgctgtcc aggttctcga cgacatcgaa     2220

aagtgcctcg aaaagaagca acagagcgtg                                      2250


<210>  34
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  34
atgctgcgtg cgaagaatca gctgtttctg ttgtccccac attacctccg ccaagtgaaa       60

gaatcgagcg gttcacggct cattcagcag agactcctgc atcagcagca gccgctacac      120

cccgaatggg ctgccctggc gaaaaagcaa ctgaaaggca aaaaccctga ggatcttatt      180

tggcatacac ctgagggaat tagcattaag ccattgtact ctaaacgcga cacaatggat      240

ctcccagaag agctacctgg cgtcaagccg tttacccgcg ggccctaccc cacgatgtac      300

acttttagac catggacgat tcgccagtat gctggtttct caactgtcga ggagtcgaac      360

aaattctata aggataacat taaagccgga cagcaagggc tctctgtggc ctttgaccta      420

gcaacccatc gcggatatga cagcgacaac cccagagtta ggggagacgt gggaatggcc      480

ggcgtggcga tcgatactgt agaggacaca aagattcttt ttgacggcat acctctggag      540

aaaatgagtg tgtccatgac aatgaatggc gcagttatac ccgtgctcgc caacttcata      600

gtcacgggcg aagaacaggg tgtacccaaa gagaaactca ccgggactat acagaatgat      660

atccttaagg agtttatggt gcgcaacacg tacatctttc cccctgagcc ttcgatgaag      720

attatcgcag atatcttcga atacactgca aagcacatgc caaagttcaa ttccatttca      780

atctccgggt atcatatgca ggaagctggg gcagacgcca tcctggaatt ggcctatact      840

ttggccgatg ggctcgagta ttcccggacc gggttgcaag ccggcctgac catcgacgaa      900

ttcgctccga ggctttcctt cttctggggg atcggcatga atttttacat ggagatagcc      960

aaaatgcgtg ccggtcgccg cctgtgggcc catctgatcg agaagatgtt ccagcctaaa     1020

aatagtaaga gtcttctgct gagggcacac tgtcagacat ctggctggtc tctaactgag     1080

caagatccat acaacaacat cgtgcggacc gctatcgagg cgatggcagc cgtcttcggg     1140

ggtacccaga gcctgcacac caattccttt gacgaggctt tagggctccc aacagtgaag     1200

tcagcccgta tagcacggaa cactcagatc atcatccagg aagagtccgg aattcctaag     1260

gttgccgacc cctggggcgg gtcctacatg atggaatgcc tgaccaatga tgtgtacgat     1320

gctgccctga aactaatcaa cgagatagaa gaaatgggag ggatggccaa agccgtggcc     1380

gagggtattc caaaactccg aatagaagag tgcgcagcca ggcgtcaagc ccggattgat     1440

agcggctctg aggtaatcgt gggcgtgaat aagtaccagt tggagaagga ggacgccgtc     1500

gaagtcctgg ctatcgacaa cacgtcagtc agaaaccggc aaatcgaaaa actcaagaaa     1560

atcaagtctt cgcgggacca ggccctcgca gagcgctgct tagcagccct taccgagtgt     1620

gcagctagtg gagatggaaa catcctggct ctcgcagtgg atgcatcaag ggcaagatgt     1680

acagttggag aaattaccga cgcactgaaa aaagtattcg gcgagcataa agcaaatgac     1740

aggatggtga gcggggctta tcggcaagag tttggcgaaa gtaaggagat cacctctgcc     1800

atcaagcgcg tccacaagtt catggagaga gagggacgca ggccaagact gctcgttgca     1860

aaaatgggcc aggacggcca cgatagaggt gcgaaagtta tcgccaccgg tttcgccgac     1920

cttggctttg atgtcgatat cggaccactc tttcagacac ctagagaggt ggcccaacag     1980

gccgtggatg ctgatgtcca cgctgttggc gtttccactc tggctgcggg acacaaaacc     2040

ctggtccctg aactgattaa ggagctgaat agcctgggcc ggcctgatat tcttgttatg     2100

tgtggtggcg tcattccgcc acaggactac gaattccttt ttgaagtcgg cgtaagcaac     2160

gttttcgggc ccggaacgcg gattcccaag gccgctgtcc aggttctgga cgacatcgag     2220

aaatgtctgg agaagaaaca gcagagcgtg                                      2250


<210>  35
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  35
atgctgaggg ctaaaaatca gctctttctg ttatcaccac actacctcag acaggttaag       60

gagtcgtctg gcagccggct catacagcag aggctgctgc accaacagca accgctgcat      120

ccagagtggg ctgcattggc caagaagcag ctcaagggta agaaccctga ggatctgatt      180

tggcatacac cagagggtat cagcatcaag ccgttatact ctaagaggga tacgatggac      240

ctgcctgagg agctgcctgg agtcaaacca ttcaccagag gcccttaccc cactatgtat      300

acattcaggc cgtggactat aaggcagtac gccggcttca gtacagttga agaatccaat      360

aagttttata aagataatat taaggccggc caacaggggc tgtccgtggc ctttgatctg      420

gctacccata ggggatatga ctcagacaac cctcgggtcc gcggagatgt aggcatggct      480

ggcgtcgcaa tcgacactgt agaggacacc aagattctct tcgacggtat ccctcttgaa      540

aagatgagcg taagcatgac aatgaacggg gcagttattc cagtgctggc caacttcatc      600

gtcacaggag aagaacaggg agtccctaaa gaaaagctga caggcaccat ccagaacgat      660

attcttaaag agttcatggt ccgcaacaca tatatcttcc cacccgaacc ttcaatgaaa      720

attatcgcgg acatatttga gtatactgcc aaacatatgc ctaaatttaa ctccattagc      780

atcagtgggt accatatgca ggaggcagga gcagacgcta ttttagaact ggcttatacg      840

cttgcagacg ggctcgaata cagtaggacc ggacttcagg ccgggctgac cattgacgaa      900

tttgctccta ggctgtcttt cttttggggg attgggatga atttctatat ggagatagcg      960

aaaatgcgag cggggcgccg gctgtgggcg catctcatcg aaaagatgtt ccagccgaag     1020

aacagcaagt ccttgttgct gagggcgcat tgccaaacat ccggatggtc tctgactgaa     1080

caggatccct ataacaacat agtgaggacc gccatcgaag ccatggctgc cgtttttggg     1140

ggcacacaaa gcctccacac aaactcgttc gatgaagctc tagggcttcc cacagttaag     1200

tccgctagga tcgcgcgcaa cactcagatt ataatccagg aggagtccgg tattcctaag     1260

gtggcagacc cgtggggggg ctcatatatg atggaatgcc taaccaacga tgtgtacgac     1320

gccgccctta agctgattaa tgagattgaa gagatgggag ggatggctaa ggcggtcgca     1380

gaaggcatcc caaagctgcg gatcgaggag tgcgctgcca gaagacaagc ccggattgac     1440

tccggttctg aagtgatcgt gggcgtgaac aaatatcagc tagagaagga ggacgctgtg     1500

gaagtgctcg cgattgacaa cacttccgtg agaaacagac agatagaaaa acttaaaaaa     1560

ataaagtcct cgcgggatca agccctggcc gaacggtgtc tcgccgctct caccgagtgc     1620

gcagcttccg gcgacggaaa cattcttgct ctggctgtgg atgcgtcaag agcgaggtgc     1680

actgtcgggg agatcaccga tgcactgaag aaggtgtttg gagaacacaa agcaaacgat     1740

cgaatggtga gcggagccta ccgacaagaa ttcggggaat ccaaggagat aacgtcagct     1800

atcaagagag tgcacaaatt catggaacgc gaggggaggc ggccgaggct gctggtggcc     1860

aaaatggggc aggacggcca cgaccgggga gctaaggtca tcgccacagg gtttgccgac     1920

ctaggcttcg atgtcgacat cggccccctt ttccagactc cccgggaagt tgcacagcag     1980

gccgttgacg ccgatgttca cgccgtcgga gtgtcaaccc tagccgccgg ccacaagacc     2040

ctggtcccag agctgataaa agagctgaat tcactcggcc gaccagatat cctggtcatg     2100

tgcggcgggg tgatcccccc ccaagactat gaatttctgt tcgaggttgg cgtttctaat     2160

gttttcggcc caggtacacg gattcccaag gcggcagtcc aagtactcga tgacatcgaa     2220

aagtgtcttg aaaagaagca gcagtcagtt                                      2250


<210>  36
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  36
atgctacgag ccaagaacca gctcttcttg ctaagtccgc attacctgag gcaagtgaag       60

gagagcagtg gcagccgact tatccagcag agactcctcc accaacagca gcccctccat      120

cccgagtggg cagccctcgc gaagaaacaa ttaaaaggta aaaacccgga ggatctcatc      180

tggcatacac ctgaaggcat ttctatcaag cctctctact caaaacggga cactatggac      240

ctgcctgagg aactcccagg tgtcaaacca ttcacacgtg ggccttaccc tacaatgtac      300

acctttagac cttggacaat tagacagtac gctggatttt ctactgtaga ggaaagtaat      360

aaattctata aagataacat caaggccggt cagcaaggcc tgtccgtcgc cttcgacctg      420

gccacacaca ggggctatga cagcgacaac ccaagagtga gaggggatgt tggcatggct      480

ggggtggcta ttgacactgt ggaagacact aagatcttat tcgacggcat cccacttgag      540

aaaatgtcgg tgtctatgac tatgaacggc gctgttatcc ccgtgctggc caattttatc      600

gtgacaggag aagagcaagg cgtcccgaaa gaaaagctca cggggaccat ccagaatgat      660

attctcaagg agttcatggt tcggaacact tatatctttc caccagaacc atccatgaag      720

atcatcgccg atatttttga gtataccgct aaacatatgc ccaaatttaa cagcatctct      780

atctcggggt atcatatgca ggaagctggc gcagatgcta ttctggagtt ggcgtacact      840

ctcgctgacg gtctggagta ttcaaggacc gggctccagg ctggcctgac tattgacgaa      900

ttcgcacccc ggctgagctt tttctggggt atcggtatga atttctacat ggaaatcgcc      960

aagatgaggg ctgggcgcag actgtgggca catctgattg agaagatgtt ccagcctaag     1020

aacagcaagt cactcttact gagggcccat tgccagacct ccggatggtc cctaacagaa     1080

caggatccct ataataatat cgtaagaacc gccatcgaag ccatggctgc cgtatttggc     1140

ggtacgcaga gcctgcacac aaactcgttt gacgaggccc tgggcctacc gaccgtgaaa     1200

tctgcgcgga ttgctaggaa cacccaaatc attatccagg aggagagtgg aatccccaag     1260

gtagcagacc cctggggtgg ctcatatatg atggagtgtc tgactaatga tgtgtacgat     1320

gctgcactca agttgatcaa tgagatcgaa gagatgggcg gaatggctaa ggccgttgca     1380

gaagggattc ctaaactgcg catcgaagag tgtgcagcca gaagacaggc gcggattgac     1440

tcgggctcag aagtcatcgt cggagtgaac aaataccagc tggagaagga ggacgcggta     1500

gaagtcttgg caatcgacaa tacgagcgtg cgcaatcggc agatagaaaa gctaaagaaa     1560

atcaaatcat caagggacca ggccctggcc gagagatgct tggcagcatt gactgaatgc     1620

gccgcgagcg gtgatgggaa tatactcgcc ctggccgtcg atgcatctag agcgcggtgc     1680

acagtcgggg aaataactga tgctctgaaa aaggtgttcg gcgaacacaa agccaatgac     1740

agaatggtgt ctggcgccta ccgtcaagaa ttcggagaga gcaaggaaat tacctccgca     1800

attaagcgcg tacacaagtt tatggaaagg gaagggcgcc ggccccgtct gctcgtggct     1860

aaaatgggac aagatggtca tgacagaggg gctaaggtga ttgctactgg gttcgcagac     1920

ctcggcttcg atgtggacat cggcccacta tttcaaaccc cgcgggaagt agcacaacag     1980

gcagtggatg ctgacgtaca cgctgtgggg gtgagtaccc tggccgccgg ccataagacg     2040

cttgtcccgg agctaatcaa ggaacttaac tccttgggtc ggccagatat attggtgatg     2100

tgtggtggtg tgattccccc acaggactat gagtttctgt ttgaggtggg agtgagcaat     2160

gtctttggac ccggtacacg catccctaaa gccgccgtcc aggtcttaga tgacattgaa     2220

aagtgccttg agaagaaaca acagtcggtc                                      2250


<210>  37
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  37
atgctcaggg cgaaaaacca actatttttg ctctcacccc attacctccg acaggttaag       60

gaaagtagtg ggagcagact catccagcag cggttgctgc accagcagca gccactgcac      120

cccgagtggg ccgcattggc caaaaagcaa ttgaagggca aaaaccccga ggacttaatt      180

tggcacaccc cagaaggaat aagcatcaaa cctctgtact caaagcgtga caccatggat      240

ttgcctgagg agctacctgg ggtgaagccc ttcacaagag ggccataccc taccatgtat      300

actttcagac cctggactat cagacagtac gccggctttt cgaccgtcga ggagtccaat      360

aagttttaca aagataatat caaggctggt cagcagggtc ttagtgtggc cttcgatttg      420

gctacccacc gggggtacga cagcgacaac ccacgcgtcc gcggagatgt aggtatggct      480

ggagtggcta ttgataccgt cgaggatacc aaaatattgt tcgacggtat accgctggaa      540

aagatgagtg tgagcatgac aatgaacgga gctgtcatcc ctgtgctcgc caacttcatt      600

gtgacaggcg aggagcaagg tgtgccaaag gaaaaactga cagggacaat acagaacgac      660

atcctgaaag agttcatggt ccggaatacc tacatctttc cacccgaacc ttctatgaag      720

attattgccg acattttcga atacaccgct aagcatatgc ccaagtttaa ttctatctct      780

ataagcggct accacatgca ggaagccgga gcggatgcca tccttgagtt agcctataca      840

ttggccgatg gcctggaata ctcccgaaca ggcctacagg cagggctaac aatcgacgaa      900

tttgcgcctc gactgtcctt tttctggggg atcggcatga acttctacat ggagatcgct      960

aagatgagag ccgggcgccg actgtgggct cacctgatcg agaagatgtt ccagccaaaa     1020

aactccaaat ctttgctgct gcgcgcccac tgccaaactt ccggctggtc cctgaccgaa     1080

caggatccct ataacaacat cgtgcgaact gcaattgaag ccatggccgc ggtgttcggg     1140

ggcacgcaat ctctccatac caatagtttc gacgaagcct tgggactccc gactgtcaag     1200

tccgccagaa tagccagaaa tacccaaatc atcatccagg aggaatctgg aattcctaag     1260

gtggcggatc cctggggtgg gtcctacatg atggagtgcc tgaccaacga cgtgtacgac     1320

gccgccctga agttgattaa cgaaattgaa gagatgggcg gcatggcaaa agccgtagcc     1380

gaaggcatcc ccaagttgag aatcgaggaa tgtgccgcca ggcgccaggc acgcatagat     1440

agtggaagtg aggtcattgt cggtgtaaac aagtaccagc tggagaaaga ggatgcagtt     1500

gaggtgcttg cgatagacaa cacaagcgtg aggaataggc agatcgagaa actgaagaag     1560

atcaaatcta gccgggatca ggccttagcc gaacgctgtc tggccgccct gacagagtgc     1620

gccgcatctg gggacgggaa catcttggcc ctggcagttg atgccagccg ggcccggtgt     1680

acggtgggcg agataaccga cgccctgaaa aaggtgtttg gggaacataa ggcgaatgac     1740

aggatggtct caggggcgta cagacaggaa ttcggagaaa gcaaggagat cacctccgcc     1800

attaagcgcg tgcataaatt catggagaga gaagggcggc ggccgagatt gctggtagct     1860

aagatgggac aggatggaca tgatcgggga gccaaggtga tagccacagg ctttgcagat     1920

ctgggctttg acgtggacat tggccccctg ttccagaccc cacgtgaagt tgcacaacag     1980

gccgtcgacg ccgatgtcca tgccgtcggc gtgagcaccc tggcggctgg acataaaaca     2040

ttagtccccg agctcatcaa agaactgaat tccctcgggc ggccagacat cctcgtgatg     2100

tgtgggggcg tgatacctcc tcaggattat gagtttctgt tcgaggtagg tgtctccaat     2160

gtcttcggtc cagggactcg cattccgaag gctgctgtcc aggtccttga cgacattgaa     2220

aagtgtctag agaaaaagca acagtctgtg                                      2250


<210>  38
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  38
atgcttcgcg ccaaaaacca actttttctg ctgtctcccc actacttgcg gcaagtaaag       60

gagagcagcg gctcccggct gattcaacag cgattactac accagcagca gcccttgcat      120

ccggaatggg cagccttagc aaaaaagcag ttaaaaggga agaaccctga agacctaatc      180

tggcatacac ctgaaggaat ctcgattaag cctctttatt ccaagcggga cactatggat      240

ttgccagaag aactccctgg cgtgaagccg ttcacgcgcg ggccttatcc cacgatgtac      300

accttccggc catggacaat ccgacaatat gccggcttca gcacggtgga agagtccaac      360

aagttctaca aggataacat caaagccggc cagcagggac tgagcgtggc attcgacctg      420

gccactcacc ggggatatga ctctgataac cctagagtaa gaggcgacgt cggcatggca      480

ggcgtcgcca tagatactgt tgaagacact aagatcttgt ttgatgggat accactggag      540

aaaatgtctg tgagtatgac catgaacggc gccgttattc ctgtcctcgc taacttcata      600

gttacaggag aggaacaggg cgtccccaaa gagaagctta ccggaaccat ccagaacgat      660

attcttaaag agtttatggt gcggaatacg tacatttttc cccctgaacc tagcatgaaa      720

atcatcgcag acatctttga gtatacagct aagcacatgc ctaagttcaa ttctatcagt      780

atttcgggct accacatgca ggaggctggg gcagatgcca tcctggagct ggcctatact      840

ttagctgacg gtttagaata ctcgcgcact ggcctccagg cgggcctcac gatcgacgag      900

ttcgccccaa ggctctcatt tttttggggc attggcatga acttctacat ggagatcgcg      960

aagatgcggg ctggccgccg cctgtgggca catctcatcg agaagatgtt tcagcctaaa     1020

aatagcaaaa gcctcctttt gcgggcccac tgccaaacat ccggatggtc gctgacagaa     1080

caggacccat acaacaacat cgtccggaca gctatcgaag ccatggccgc cgtgttcgga     1140

ggaactcaga gcctccacac gaattcattt gacgaggcct tggggctccc cacagtgaag     1200

agcgccagaa tcgctcggaa cacccagatt atcattcaag aggagagcgg gatacccaag     1260

gtggccgatc cgtggggtgg cagctacatg atggagtgcc tgacaaacga cgtttacgac     1320

gccgccctca agctgataaa cgagatcgag gagatggggg gtatggcaaa ggccgtcgct     1380

gaggggattc ccaaactgag gatcgaagaa tgcgcagctc ggcgacaggc tcgaattgac     1440

agcggttctg aggtgatcgt tggagtgaat aaatatcagc tggagaagga agacgcagta     1500

gaggtcctgg ccatcgataa cacaagtgtg agaaatcgac agatagagaa gttgaagaaa     1560

attaagtcat ctagagacca ggctctcgca gaacggtgtc tcgcagcact cacagaatgt     1620

gcagcaagtg gggacggtaa tatcctggcc ctcgcagttg acgcgtctcg cgctaggtgt     1680

accgtgggcg agatcaccga tgctcttaaa aaagtgttcg gggagcacaa agcgaacgat     1740

aggatggttt ccggcgctta caggcaggaa tttggagaga gcaaggaaat cacatctgct     1800

attaaacgag tgcacaaatt catggagcgg gaaggcagaa ggccacgctt gctagtcgcc     1860

aagatgggtc aagatggaca tgaccgcggc gccaaggtaa tagctaccgg gtttgccgat     1920

ttgggcttcg atgtggacat cgggcctctg ttccagacac ctagagaggt ggcccagcag     1980

gctgtcgatg ccgatgtcca tgcagtagga gtatcgaccc tcgcggcggg gcataagaca     2040

ctggtgcctg agctgatcaa agagttgaac tctctcggaa ggccagacat actggtcatg     2100

tgcggtggag tcattccacc ccaggactac gaatttctgt tcgaggtggg cgtttccaat     2160

gtctttggcc ccggcactcg catccccaaa gctgccgtgc aagtcctgga tgacatagag     2220

aaatgtctgg agaagaaaca gcaatccgtc                                      2250


<210>  39
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  39
atgcttagag cgaagaacca gcttttcctg ctgtctcccc attatctcag acaagtaaaa       60

gagtcttccg gtagccggct gatccagcaa aggttattac accagcaaca gccacttcac      120

cccgagtggg cggccttagc caagaagcag ctcaaaggca aaaatcctga ggacctaatt      180

tggcacaccc cagagggcat ctccattaag cctttgtact cgaagcgcga cacaatggat      240

ttgcctgagg aattacctgg ggttaagcct tttaccaggg gaccctatcc cacgatgtac      300

acattccgac cttggacaat tcgccaatat gctgggttca gtacagtgga ggaaagcaac      360

aagttttaca aagacaacat aaaagccggt caacagggcc tgtctgtcgc attcgatctt      420

gccactcacc gcggctacga ctctgataac ccgagagtcc gcggggatgt gggcatggca      480

ggagttgcta tcgacacagt cgaagacacc aagattctgt ttgacggtat accactggag      540

aagatgtcag tttcaatgac tatgaatggc gcggtgatcc ctgttctagc aaactttata      600

gtgactgggg aggagcaggg ggtgccgaag gaaaagttaa ctggaactat tcagaacgac      660

atccttaaag aattcatggt gcgaaacacg tacatcttcc ccccggagcc cagcatgaag      720

ataatcgcag acatctttga atacaccgcg aagcacatgc ccaagttcaa ctcaattagc      780

atctcagggt accatatgca ggaagcgggg gccgatgcca tcctcgaact ggcttacacg      840

cttgcggatg gcctagagta tagtagaacc ggattacaag ctggcctcac aatagatgaa      900

tttgcccctc gtctcagttt tttctggggc atcggaatga acttttatat ggagattgct      960

aagatgcggg caggccgccg tctctgggcc cacctgattg agaaaatgtt tcagcccaag     1020

aactccaaat cactgctgtt aagggcccat tgccagacca gcggctggtc cctgaccgaa     1080

caggacccct acaataatat tgtgcgcact gccatcgagg ccatggcagc agtgttcggt     1140

gggacacaga gccttcatac caacagtttt gatgaggccc tggggttacc taccgtcaag     1200

tccgcgcgca tcgcccgcaa cacccaaatc attatccaag aagagtccgg aatacccaag     1260

gtcgcagacc catggggggg gtcctacatg atggagtgcc ttaccaatga cgtgtatgat     1320

gctgccctaa aacttattaa tgagatcgaa gaaatgggag gaatggctaa ggcagtcgcg     1380

gaaggaattc ctaaactcag aattgaagaa tgtgctgcca gacggcaagc acgtatagat     1440

tctgggtccg aggtaatcgt cggggtcaac aagtaccagc ttgaaaagga ggatgctgtg     1500

gaggtcctgg ccattgacaa cacgagtgtg cggaatcgac agattgagaa gctgaagaaa     1560

attaagagct cacgagacca ggctctggcg gagcgctgcc tggcagcact gaccgagtgt     1620

gctgcttcag gtgatggtaa tatccttgcc ctagccgtgg acgccagtcg cgcccgatgc     1680

acagtggggg agattaccga cgccctcaaa aaggttttcg gagaacacaa agccaacgat     1740

cgcatggtgt caggagctta ccgacaggag tttggtgaga gtaaagaaat tacatccgct     1800

atcaaacgag tgcataaatt catggagaga gagggtagac ggcctagact cctggtggcc     1860

aagatgggac aggacggtca cgatcgtggt gctaaggtta tcgccacagg cttcgctgat     1920

ctgggattcg atgtagatat cggccctctg ttccaaactc ctcgggaagt ggcacaacag     1980

gctgtcgatg ctgatgtcca tgcagttgga gtaagcacac ttgcagctgg acataagaca     2040

ctcgtgcctg agctgatcaa ggaactgaac agcctgggga ggccggacat tttggtcatg     2100

tgcggggggg tcatcccccc ccaggactat gaattcttgt ttgaggtggg agtgtcaaac     2160

gtcttcggtc ccggcacacg gatccccaag gctgcagtgc aggtgcttga tgatatcgag     2220

aagtgcctcg agaagaagca gcaatccgtt                                      2250


<210>  40
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  40
atgctgaggg ctaaaaacca attgttcctt ctgagccctc actatcttcg gcaggtcaaa       60

gaaagctcag gctcacgcct cattcagcag cggctgctcc accagcagca gccactgcat      120

ccagagtggg ctgcattagc aaagaagcaa ctcaaaggca agaaccctga agacttaatc      180

tggcataccc ccgaggggat cagcatcaaa cccttatatt caaagcggga tactatggac      240

ttgccggaag agttacccgg cgtcaaaccc tttacgcgcg gcccataccc tacaatgtac      300

accttccggc cctggaccat ccgccagtat gccgggttta gcaccgtcga ggaatctaat      360

aagttttata aggataacat taaagctggg caacaaggac tgtcagtcgc ttttgatttg      420

gccacacata gaggatacga ttctgataac ccacgggtga ggggtgacgt ggggatggcc      480

ggagtggcta tcgataccgt tgaggacaca aagatccttt ttgacggcat tcctctcgag      540

aaaatgtctg tcagtatgac catgaatggg gccgtcatcc ccgtgcttgc caacttcata      600

gttacgggag aggagcaggg agtgccgaaa gagaaactga ccgggactat ccagaacgac      660

attctgaagg aattcatggt gcggaatacc tacatattcc cccccgagcc aagcatgaag      720

atcattgccg acatcttcga gtatactgct aaacacatgc ccaagtttaa ttccatcagt      780

atcagtggct atcacatgca ggaggcagga gcggacgcca tcttggaatt ggcatacact      840

ctggcggatg gtctcgagta ttcacggact ggactgcagg ctggcctgac catcgacgaa      900

tttgcgccgc gcttatcgtt cttctggggc atcggaatga atttctatat ggaaatcgcc      960

aaaatgaggg ccggtagacg cctgtgggcc catttgattg aaaaaatgtt ccagcccaag     1020

aattccaagt ccctattact aagggctcat tgtcaaacat ctggatggag tttaacggag     1080

caggacccat acaacaatat agtgcgcaca gctattgagg caatggcagc cgtgttcgga     1140

ggcactcaat cactgcatac aaatagtttc gatgaagctc tggggctccc caccgtgaag     1200

agcgccagaa ttgcccgaaa cacccagatc atcatccagg aagagtctgg catcccaaag     1260

gtagctgacc cctggggcgg cagctacatg atggaatgcc tgactaacga tgtctatgac     1320

gctgctctga agctgattaa cgaaattgaa gagatgggcg ggatggccaa agcggtggca     1380

gagggcatcc ctaagctccg gattgaggaa tgtgctgcac gcagacaggc ccggattgac     1440

tccgggagcg aggttatcgt tggtgtaaat aaataccaac tcgagaaaga ggatgccgtt     1500

gaagtactcg caatcgacaa cacctcagtg cggaataggc agatcgagaa gctgaaaaag     1560

atcaaaagct ctagggacca ggccctggct gagcgttgtc tcgcagcttt aacagagtgt     1620

gccgcttcag gtgatggtaa tatccttgcc cttgccgttg acgcatcgag agctagatgc     1680

acagtgggtg agattactga tgccctaaag aaagtatttg gtgagcataa agccaatgat     1740

aggatggtct ccggagcata cagacaggaa tttggcgagt caaaggagat tacctcagcc     1800

atcaaacgcg tccataaatt catggagaga gaaggaagga ggccacggtt gctagtggca     1860

aagatgggcc aggacggcca tgatagggga gctaaggtca ttgcaaccgg ctttgccgac     1920

ttgggcttcg acgtggacat cggccctcta tttcagactc cacgggaggt ggcacagcag     1980

gctgtggatg cggatgtgca cgccgtgggg gtgtctaccc tggctgccgg gcacaagact     2040

ctggtgcctg agcttattaa agagttgaac agcctgggcc gacccgacat actcgtgatg     2100

tgcggcggtg tcataccgcc tcaggattat gaatttctgt ttgaagtggg cgtgagcaat     2160

gtgtttggac ctggtacacg catcccaaag gctgctgtgc aggtgttaga tgatatcgaa     2220

aagtgtctgg aaaaaaagca gcagagcgtc                                      2250


<210>  41
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  41
atgctgcgtg cgaaaaacca gcttttcctg ttgagtccac actacctgag acaagtcaaa       60

gaatcaagcg gttccaggtt gattcagcag cggttgctcc accagcagca gccactccac      120

ccagagtggg cagcactggc aaagaagcag ttgaaaggta aaaaccctga agacctgatt      180

tggcacactc ctgaaggcat ttcaatcaaa cctctgtaca gcaagcgcga cacgatggat      240

cttcccgaag aactccccgg tgtcaaacca tttactagag gcccctaccc tacaatgtat      300

acctttcggc catggactat ccgacagtac gctggatttt ccaccgtcga ggaaagtaac      360

aagttctata aggataacat taaggccggc cagcagggac tgtcggtagc ctttgacctc      420

gcaacccatc ggggctacga tagcgataac ccaagagtga ggggagatgt gggcatggcc      480

ggtgtggcga ttgatactgt ggaagacact aagatactgt tcgatgggat tcctctcgag      540

aaaatgtcag tctccatgac catgaacggg gctgtcatac ccgtgcttgc taactttatt      600

gtgacaggcg aagagcaggg agtgcctaag gagaaactga ccggcacaat tcagaacgac      660

atccttaagg aattcatggt tagaaatacg tacatctttc ctcccgagcc tagtatgaaa      720

attatagcgg acatctttga atatactgcc aaacacatgc caaagtttaa tagcatatcc      780

atatcaggat atcatatgca ggaagcaggt gcggatgcta tccttgagct ggcatacacc      840

ctggctgatg gtctcgaata ttctagaacg ggattacagg ccggtctcac aattgatgaa      900

tttgcaccaa gattaagctt tttttgggga attgggatga atttttacat ggaaatagct      960

aaaatgcgcg cgggacgccg cctctgggcc caccttatcg agaaaatgtt ccagccgaag     1020

aatagtaaga gtctcctcct gagagcccac tgccagacta gcggatggag cctgactgaa     1080

caggacccct acaataacat cgtccggaca gccattgagg ccatggcggc agtcttcggt     1140

ggaactcagt cgctgcacac aaattctttc gatgaagccc tcggcctacc aactgtgaaa     1200

tctgccagaa ttgccaggaa cacccagatc attattcaag aggagagtgg gattcctaag     1260

gtcgccgacc cctggggcgg gtcatatatg atggaatgtc tcaccaatga cgtgtacgac     1320

gccgcactca agttgataaa cgagattgag gagatgggcg gcatggctaa ggctgtggcc     1380

gagggcattc ctaaactcag aatcgaggag tgtgccgccc ggcgacaggc gcgtatagac     1440

agcgggagtg aggtcattgt tggagtcaac aaatatcaac tagagaagga agacgcggtg     1500

gaggtgctgg ctatcgacaa tacctcagtg cggaatcggc agatcgagaa gctcaagaag     1560

attaagtctt caagggacca ggccctggct gagcgctgcc tggctgccct gaccgaatgc     1620

gccgccagtg gggatgggaa cattttggct ttagcggtcg acgcttccag ggcccgttgt     1680

accgtagggg agattactga tgcattgaaa aaagtgtttg gtgaacataa agccaacgat     1740

cggatggtta gtggggctta taggcaagaa tttggagaat ccaaggagat caccagtgcc     1800

ataaaaagag tgcacaaatt catggaacgc gagggccggc ggcctcggct cctggttgca     1860

aagatggggc aggacggcca tgaccggggg gccaaagtga tcgccaccgg atttgcggat     1920

ctcgggtttg acgtggacat tggcccgcta ttccagacgc ctcgtgaagt agcacagcag     1980

gccgtggacg ccgatgtcca tgctgtggga gtgtcaacac tggctgccgg gcacaaaaca     2040

ctggttccag agttgatcaa ggaactgaat tctcttggtc ggcctgatat tcttgtaatg     2100

tgcggcggag tcatcccacc gcaggactac gagttccttt ttgaggtggg ggtatcaaac     2160

gtgtttggac ctggaacgcg cattccaaag gctgccgtgc aggtgcttga tgatatcgaa     2220

aagtgcctgg aaaaaaagca gcagtccgtg                                      2250


<210>  42
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  42
atgcttagag caaagaatca gttattcctg ctgagtcccc attacctgcg acaggtgaag       60

gaaagctcag gcagcagact gatccagcag cgcctgctgc accaacagca gcctctgcat      120

ccagagtggg ccgctctcgc caagaagcag cttaagggaa aaaaccctga agatctgatt      180

tggcacacac ccgaaggtat ctcaataaaa cccttgtatt ctaagcgcga tacaatggac      240

ttgccagaag aactgcctgg agtgaaaccc tttacaaggg ggccctaccc aacaatgtat      300

acatttaggc cttggacaat tagacagtac gcgggtttta gcactgtcga ggagtccaac      360

aaattctaca aggataacat caaagcgggc cagcaaggac tgtcagtggc atttgacttg      420

gccactcata gggggtatga cagtgataac cctcgggtgc gaggtgacgt gggaatggcc      480

ggggtcgcga tcgatacagt ggaagacacc aaaatcctct tcgatgggat acccctggag      540

aagatgtccg tttcgatgac gatgaacggg gccgtgatcc cagttctcgc taacttcatt      600

gtaactggcg aggaacaggg agttcccaaa gagaaactga ccggcactat tcagaacgat      660

atcctaaagg aattcatggt gcggaatacc tacattttcc ctccagagcc ctctatgaag      720

attatagcag atatcttcga gtataccgcc aaacacatgc caaaatttaa ttccatttcc      780

atctctggct accacatgca ggaggccggc gcagacgcca tcctcgagct tgcctacact      840

ttggcagatg ggttagaata ctcacggaca ggactacagg ctggtctgac aattgatgaa      900

ttcgcccctc gcctgtcatt cttttggggg ataggcatga atttctacat ggagatcgcc      960

aagatgcgcg ccggcagaag actgtgggca catctcatcg aaaagatgtt ccagcctaaa     1020

aactccaaga gcctgttatt aagagctcac tgccagacct ccgggtggag tctgactgag     1080

caggatcctt acaacaatat cgtcagaaca gcaatcgagg caatggccgc cgtttttggg     1140

gggacgcagt ccttgcatac aaattctttc gatgaagctc tcggactgcc taccgtcaaa     1200

tccgcgagaa tcgcgcggaa cacccaaatc ataattcagg aggaatccgg aattcccaaa     1260

gtggcggacc catggggagg gagttacatg atggaatgcc tcaccaatga tgtgtatgat     1320

gcagcactca agctgattaa tgaaatcgag gaaatgggag gtatggcaaa agctgtcgca     1380

gagggcatcc ccaagctgag aatcgaagaa tgcgccgcca ggaggcaggc cagaattgat     1440

tctgggagtg aggtgatcgt gggggtgaac aagtaccagc ttgagaagga agacgcagtt     1500

gaggttctcg ccattgataa tacctcagtg cgcaaccggc agattgagaa actcaagaag     1560

attaagagct ccagggacca ggcacttgct gagcgttgcc tcgcggcact gacagagtgc     1620

gctgcaagcg gggatggtaa catcctcgct ctggccgtcg acgcaagcag agctcggtgc     1680

acggttggag agatcaccga cgccctgaag aaagtgttcg gcgagcacaa ggccaacgac     1740

agaatggtgt cgggggcgta ccgccaggaa tttggtgagt ccaaggagat cacaagtgcc     1800

atcaaaaggg tgcataaatt tatggagaga gagggacgac ggcctcgcct tcttgtggcg     1860

aaaatgggac aggatggcca cgatcggggt gctaaggtga tcgcgacggg ctttgccgac     1920

cttggctttg acgtggacat tggacccctt tttcaaacac ctcgagaagt ggcacagcag     1980

gctgtggatg cagacgtgca tgccgtgggg gtctcaacac tggctgccgg ccacaagact     2040

ctggtccccg agctgattaa agagctgaat tccctgggga gaccagacat cctcgttatg     2100

tgtgggggcg tgattcctcc tcaagactac gagttcctct ttgaggttgg cgtttcaaac     2160

gttttcgggc ccggcacacg gatacctaaa gcagctgtcc aggtgctaga cgatattgag     2220

aagtgtcttg aaaagaagca acagtctgtc                                      2250


<210>  43
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  43
atgcttcgcg ctaagaatca gttgtttctg ctgtcacctc actatctaag acaagtcaaa       60

gagtcatccg gctctagatt aatccaacaa cggctgttgc accagcagca acctttgcac      120

cctgaatggg ccgccttggc taaaaagcag ctaaagggga aaaatccaga agacctgatt      180

tggcatacac cagagggtat aagtattaag ccactgtatt ctaagcgcga caccatggac      240

ctccccgagg agttaccagg ggtgaagcct ttcaccagag ggccctaccc caccatgtac      300

acctttaggc cttggactat tcgacagtat gcagggttta gcaccgttga agagtctaat      360

aagttctaca aagacaacat caaagccggg cagcaaggcc tttctgtggc tttcgacctg      420

gcaacacatc gcggctacga ttctgataac ccgcgtgtga ggggcgatgt tgggatggct      480

ggcgtcgcta tcgacacggt cgaggacaca aagatcttat ttgatggaat ccctcttgaa      540

aagatgagtg tcagcatgac catgaacggc gctgtgatcc cagtactggc taactttatt      600

gtgacagggg aggaacaagg ggtgccgaaa gagaaactca caggaactat tcagaacgat      660

atcttaaaag agtttatggt gcggaacact tatattttcc cccccgaacc tagcatgaaa      720

ataattgccg acattttcga gtatactgct aagcatatgc ctaaattcaa ctctattagt      780

atcagcgggt atcacatgca ggaggccggg gcggatgcca tactggagct ggcctacacc      840

ctagccgacg gactggaata ttcacgtact ggcctgcagg ctggacttac catcgacgaa      900

tttgcacccc gactgagttt cttctgggga atagggatga atttttatat ggagattgct      960

aagatgagag ctggacgcag gctctgggcc cacctgatcg agaagatgtt tcaacctaaa     1020

aactccaaga gcttgctatt gcgagcccac tgtcaaacct cagggtggag tctgactgaa     1080

caggaccctt ataacaatat tgtgaggacc gccatcgagg caatggcagc tgtattcggc     1140

ggaacccaga gcctgcacac aaactctttc gacgaagctc tgggcctgcc aaccgtcaaa     1200

tccgccagga tagccaggaa cacccagatt attatccaag aagaatctgg tatccccaag     1260

gtcgccgatc cttggggcgg ctcttacatg atggagtgct taaccaacga tgtgtacgat     1320

gcagctttga aactcatcaa cgaaatcgaa gaaatggggg ggatggcaaa agcggtcgca     1380

gagggtattc ccaagctgcg gatcgaagag tgtgcggcaa gacggcaggc acggattgac     1440

agcggttccg aggtgatagt cggcgtgaac aaataccagt tagagaaaga agatgctgtc     1500

gaggttctgg ccatcgacaa cacaagcgtg cgcaacagac aaatcgaaaa actaaaaaag     1560

ataaaatctt ccagagacca ggctctcgcg gagcgctgcc tggccgcgtt gaccgagtgc     1620

gccgcctcgg gcgacggaaa tatcctggcc ctggccgtcg acgccagtag ggcccggtgt     1680

acagtgggag agatcaccga tgcgctgaaa aaagtttttg gggagcacaa agccaacgat     1740

aggatggtgt ccggggcgta tcgtcaggag ttcggcgaga gtaaagaaat tacctctgcc     1800

ataaagcggg ttcacaaatt tatggaaaga gaaggcagga ggcctagact gctcgtggcc     1860

aaaatggggc aggacggcca tgacagggga gccaaagtta ttgccactgg ctttgccgat     1920

ttggggtttg atgtcgacat aggcccccta tttcagaccc ctagggaagt ggctcaacag     1980

gccgtggatg ccgacgtaca cgctgtcggg gtgtccaccc tcgctgcagg ccacaagaca     2040

ttagttcctg aactgatcaa agaactgaat tcactaggcc gccccgacat tctggtgatg     2100

tgcggcggtg tgattccacc tcaggactat gaattcctct ttgaggtggg tgtctctaac     2160

gtgttcggac caggtacccg aattcctaaa gccgcagtgc aggtgctcga cgacattgag     2220

aagtgtcttg agaagaaaca gcagtcagtg                                      2250


<210>  44
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  44
atgctgagag ctaaaaatca actgtttctt ctgtcgcccc attaccttcg tcaggtaaag       60

gagagcagtg gttcccggct aattcaacag agactgctgc accaacagca acccctgcac      120

cctgagtggg cggccctggc caagaaacaa ttgaagggca agaacccgga ggacctcata      180

tggcatacac cagagggtat ctccatcaag cctctgtaca gtaagcgcga tactatggat      240

ctgccagaag aactcccagg cgtgaaacca ttcacaagag ggccctaccc caccatgtac      300

actttcaggc cgtggacaat aaggcaatat gcagggtttt ccacagtcga ggagagtaat      360

aagttctaca aggataatat taaagctggt cagcaggggc tgtctgtggc cttcgattta      420

gctacgcatc ggggatacga ttctgataac ccccgggtcc ggggcgacgt gggcatggcc      480

ggggtggcta tcgacactgt cgaagatacc aaaatcttgt tcgacgggat tccactagaa      540

aaaatgagcg tcagcatgac gatgaacggc gccgtcatac cagtgctcgc caattttatc      600

gtcactggtg aggaacaggg ggtcccaaag gagaaactta ctgggacaat ccagaatgac      660

attttaaagg aatttatggt gcgtaacacc tatatcttcc caccagagcc atctatgaaa      720

ataatcgctg acatcttcga atataccgcc aagcatatgc ccaagttcaa cagtatttca      780

attagcggct atcacatgca ggaagcaggg gccgatgcca tactggaact cgcttatacc      840

cttgctgacg ggctggaata cagtagaact ggtctgcagg caggcctcac aatcgatgaa      900

ttcgcaccac gtctgtcatt tttctggggc attggcatga atttctacat ggagatcgct      960

aaaatgaggg cagggcggag actgtgggcc catctgatcg agaaaatgtt tcagccaaag     1020

aactccaaaa gtttgctgct gcgcgcgcac tgtcagacga gtggatggtc cttgaccgag     1080

caggacccct ataataacat cgtgcgtacg gctattgaag ccatggcggc cgtgtttggc     1140

ggcacccaaa gcctgcacac taatagtttc gatgaagccc tgggcctgcc caccgtaaaa     1200

agcgcccgaa tcgcccggaa cacacagatt atcatccagg aggaaagtgg aatccctaaa     1260

gtggcagatc catggggcgg cagctacatg atggaatgcc tgacaaacga cgtgtatgac     1320

gctgccttaa agctcatcaa tgagatcgag gagatgggag gcatggctaa agccgtggct     1380

gagggcatcc ctaagctgcg gattgaagag tgtgccgcgc ggcgacaggc caggattgat     1440

agcggaagtg aagttatcgt gggtgtgaac aaatatcagc ttgagaaaga ggacgccgta     1500

gaggtcctgg ccatcgacaa taccagtgtg cgcaataggc aaattgagaa actgaagaag     1560

attaagtcta gcagggatca ggccctggcc gagcggtgcc tggctgccct caccgagtgc     1620

gcagcgagcg gagatggtaa tatactggct ctggcggtgg atgcctcgcg ggcacgatgt     1680

acggtgggcg agatcacaga tgcccttaaa aaggtgtttg gcgaacataa agccaatgat     1740

agaatggtgt ctggagcata tcgtcaggaa ttcggtgaaa gcaaagagat cacaagtgcg     1800

atcaaacgag tgcataaatt tatggaaaga gaagggcgca gaccacgtct gctggtggct     1860

aaaatggggc aggatggcca cgatcgagga gcaaaagtta tcgccacagg ttttgccgac     1920

ctggggtttg atgtagacat aggccccttg tttcagacac ctagggaggt ggcgcagcag     1980

gccgttgacg ccgatgtgca tgctgtggga gtgtccacac tcgcggccgg ccataagacg     2040

ctcgtgcccg aactgattaa agagttgaac agcctgggga ggccagacat tctcgtgatg     2100

tgtggaggcg tgattccccc acaggattat gagtttcttt ttgaggtcgg cgtgtctaat     2160

gtgttcggtc ctggtacccg gattcccaag gcagctgtgc aggtcctaga cgatatcgaa     2220

aagtgcctgg agaagaagca acaaagcgtt                                      2250


<210>  45
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  45
atgttacgag ccaagaacca gctgtttctg ctttctccgc actacctcag gcaggtgaag       60

gagagtagcg gaagcagact gatacagcag agactcttac accagcaaca gcctctccac      120

cctgaatggg ccgccctcgc aaagaaacag ctgaagggaa aaaatccaga ggacctgatt      180

tggcacactc ctgaagggat cagcattaaa ccgttgtaca gcaaacgtga caccatggat      240

ttgccagagg aactgcctgg agttaaacct tttacacgcg gcccataccc tactatgtat      300

acgttcagac catggacaat cagacagtat gccggtttct caaccgtgga ggagtccaac      360

aagttctata aggataacat aaaggccgga cagcagggtt tgtctgtagc tttcgatctg      420

gctactcaca gaggttatga cagcgacaat ccacgcgttc gcggggacgt gggcatggct      480

ggggtcgcaa tagataccgt cgaggataca aagattctct tcgacgggat ccctctggag      540

aagatgtcag tgtccatgac catgaacggt gctgttatcc ctgttcttgc taatttcatt      600

gtaaccggcg aagaacaggg cgttccaaag gagaaactga ccggaactat ccagaacgat      660

atcctcaaag agttcatggt caggaacact tacatcttcc cgcctgaacc ttctatgaag      720

attattgccg atattttcga gtacactgca aagcatatgc ctaagttcaa cagtatcagc      780

atatccggct accatatgca agaggccggc gccgacgcaa ttctcgaact ggcttacact      840

ttggctgacg gcttagagta cagcaggact ggtctccaag ccgggctgac gattgatgaa      900

tttgcccctc ggcttagttt tttctggggc atcggcatga atttctacat ggagatagcc      960

aagatgaggg ccggcaggcg gttgtgggca catctcatcg agaaaatgtt ccaacccaag     1020

aatagcaagt ccctcctact tcgagcccat tgccaaacga gtggctggtc attaaccgag     1080

caagatcctt ataataatat cgtgaggaca gccattgagg caatggcagc ggtcttcggt     1140

ggaacacaga gtctgcacac gaacagcttt gatgaagccc ttggactgcc tacggtcaaa     1200

agcgccagga tcgctcggaa cacacagatc attatccaag aggaatctgg catccccaag     1260

gtggctgatc cctggggagg ctcttacatg atggaatgcc tcacaaacga cgtctacgac     1320

gccgccctga agttgatcaa cgagatcgag gaaatggggg ggatggctaa ggcagtagcc     1380

gagggaattc ctaagcttag aatagaggaa tgcgctgccc gacgccaggc tcggatagac     1440

agtggttccg aggtcatcgt gggcgtgaac aaataccaac tcgagaagga ggacgccgtc     1500

gaggttctgg ccatcgacaa cacgtcagtt cgtaaccgac aaatcgaaaa attaaaaaaa     1560

ataaaatcta gcagggacca ggctctggcc gagcgttgcc ttgccgcact gactgagtgt     1620

gcagcctcag gcgacggaaa catactggcg cttgcagttg atgccagccg ggctagatgt     1680

accgttgggg agatcacgga cgctctcaaa aaagtgttcg gcgagcacaa ggcgaatgat     1740

cgaatggtgt ccggcgccta tcgtcaggag tttggcgagt ccaaggaaat tacctcagca     1800

atcaagagag ttcacaaatt tatggagcgc gaagggcgcc ggcctcggtt gctcgtcgct     1860

aagatgggac aggacggcca tgaccgtggc gccaaggtga ttgcgactgg ctttgcagat     1920

ctaggcttcg acgtagatat aggcccactg ttccagacgc cccgagaagt ggcgcagcag     1980

gccgtggacg ccgacgtcca cgctgtcgga gtgagtacct tggcagccgg ccacaaaaca     2040

ctggtgccag agcttattaa ggagctaaat tccctggggc ggccagacat cctcgttatg     2100

tgtggagggg tgataccgcc ccaagactat gagttcctgt tcgaggtggg ggtgagtaat     2160

gtcttcggcc ccggcacacg aattcccaaa gcagcagtgc aagtgctgga cgacattgag     2220

aaatgccttg agaagaagca acagagcgtg                                      2250


<210>  46
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  46
atgctacggg ctaaaaacca gttgtttctc ctatcccccc attatcttcg tcaagtcaaa       60

gagtccagcg ggtccagact gattcagcaa aggctgctgc accaacagca gcctttgcac      120

ccagaatggg ctgcacttgc taagaagcag ttgaagggca aaaatcctga agacctaatt      180

tggcataccc cagaaggaat cagcatcaag ccgctatatt ccaagcgaga taccatggac      240

ctcccagagg agctacccgg tgttaagcct tttacccggg gaccttatcc gacaatgtac      300

acctttcgac cttggacaat caggcagtac gccggatttt ccactgtgga agagagcaat      360

aagttctaca aggacaacat caaagccggc cagcaggggc tgtccgtggc attcgatttg      420

gcaacacacc gcggctacga tagcgataat cctagagtgc gcggcgatgt ggggatggca      480

ggcgtcgcga tagataccgt tgaggatacc aaaatcctgt tcgacggcat ccctctggag      540

aaaatgtcgg tctctatgac aatgaatgga gccgtgatcc ctgtgctcgc gaactttata      600

gtcacgggcg aggaacaggg agttccaaag gaaaaactga cagggactat ccagaacgat      660

atcttaaaag agttcatggt gcggaacacc tatatattcc cacctgagcc ctccatgaag      720

atcattgccg acatctttga gtataccgct aagcacatgc cgaagttcaa ttctatttca      780

atctccggtt accatatgca ggaggccgga gcggatgcta tcctagaact ggcatacaca      840

ttggcggacg gcctagaata ttctagaacc ggtctgcagg cagggctcac catcgatgaa      900

ttcgccccgc ggctgagttt cttctggggc attggaatga atttctacat ggaaattgcc      960

aagatgcgtg caggtcggcg cctgtgggcc catttgatcg aaaaaatgtt tcagccaaag     1020

aacagcaagt ctctgctgct gagagctcac tgccaaactt ccggatggtc cctcaccgag     1080

caggatccct acaacaatat cgtgcggacc gccatcgagg caatggctgc cgtgttcggc     1140

ggcacccaat ctcttcacac caatagtttt gatgaagcct taggactgcc aaccgtcaaa     1200

tccgcacgga tcgctcgaaa tacacaaatc ataattcagg aggagagtgg gatccctaag     1260

gtcgcagatc cctggggcgg tagttacatg atggagtgct tgaccaatga cgtctacgac     1320

gccgcactca aactgatcaa cgagatcgag gagatgggcg ggatggccaa agcagtcgct     1380

gaggggatcc ctaaactccg tattgaagag tgtgcagccc gccggcaagc tcggatcgat     1440

tctggctcag aagtcatcgt tggcgttaac aagtaccagc tagaaaaaga agatgcagta     1500

gaggtgctcg ccatagacaa tacctccgtg cgcaaccgcc aaattgagaa attgaagaag     1560

atcaagtctt ctcgcgacca ggccttggcc gaaaggtgct tagctgcatt aactgaatgt     1620

gctgcatcag gggatggtaa tatactcgct ctggcagtcg acgcgtcccg tgccaggtgc     1680

acagtggggg aaattactga cgcactgaaa aaagtgtttg gtgagcacaa ggccaacgat     1740

aggatggtct ctggtgctta tcggcaggag tttggggagt ctaaagagat aacttctgct     1800

attaagcgcg tgcataagtt catggagcgc gaaggacggc gtccccgact gctggtggcc     1860

aaaatgggac aagacggcca tgacaggggg gccaaagtga tagcaaccgg gttcgcagat     1920

ctgggcttcg acgtcgatat cggaccactt ttccagacac ctagggaggt cgctcaacaa     1980

gcagtcgatg ccgacgtcca tgcggtgggc gtgtccaccc tggctgccgg acacaaaacc     2040

ctggtgccag aattgattaa ggagctaaac tctctgggcc ggccagacat cctggtgatg     2100

tgtggcggag tgattcctcc tcaggattat gagtttctgt tcgaggtcgg ggtatctaat     2160

gtgtttgggc ccgggactcg catcccaaaa gcggctgtcc aggtgttgga cgacatagag     2220

aagtgccttg agaaaaagca gcagagcgtg                                      2250


<210>  47
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  47
atgctgcggg caaagaacca gctgtttctc ctaagccctc attacctccg ccaggttaag       60

gagtctagtg gctctaggct gattcagcaa cgcctactgc accagcaaca acccctgcac      120

cccgaatggg cggccctggc aaaaaagcag ctcaagggca agaatccaga ggatctgatc      180

tggcacacac ccgaaggcat ctccatcaag ccgctctata gcaaaagaga cactatggac      240

cttccggaag agctacccgg agttaaaccc ttcaccagag gaccttaccc caccatgtac      300

acatttaggc catggaccat ccgtcagtac gccggattct ctaccgtgga ggagtcgaat      360

aagttctaca aggataacat caaggccggg cagcaaggcc tctctgtcgc ttttgatctg      420

gccacacatc gggggtacga cagcgacaac ccacgcgtga ggggagatgt aggaatggct      480

ggcgtggcga ttgacaccgt tgaggacact aaaatcctct tcgatggcat acccctggag      540

aaaatgagcg tgtcgatgac tatgaatggt gccgtcatcc cggtcctggc taatttcatc      600

gtgaccgggg aggaacaggg cgtgcctaag gaaaaattaa ccggcactat ccagaatgat      660

attctgaagg agttcatggt caggaatacc tatatttttc ccccggaacc atcgatgaag      720

atcattgccg acatcttcga gtacacagca aagcacatgc caaagttcaa cagcataagc      780

atctccggat accatatgca ggaggccgga gctgacgcta tccttgagct ggcatacacg      840

ttggcggatg gtctggagta ttccagaaca ggcttgcagg ccggcctgac gatcgacgag      900

tttgcacctc ggctgtcctt cttttggggt attggtatga acttttacat ggagattgca      960

aagatgcgag caggtaggcg cctttgggcc caccttatcg aaaaaatgtt ccagcccaag     1020

aacagcaaga gcctactgct tagagctcac tgtcagacgt ccggatggtc tttgacggaa     1080

caggatcctt acaataacat tgtccggact gctatagagg caatggcagc cgtgttcgga     1140

gggacacaga gcctccacac caactcattc gacgaggcac ttggcctccc cacggtcaaa     1200

tccgcccgta tagccagaaa tacacagatt attattcagg aagaatcagg catccctaaa     1260

gtggccgacc cttggggggg cagttatatg atggagtgcc tgacaaacga cgtgtacgac     1320

gccgcactca agctgattaa tgagattgag gagatgggcg ggatggctaa ggctgttgct     1380

gaaggcatcc ctaagctacg catcgaggaa tgtgccgcga gacggcaagc tagaattgat     1440

agcgggtctg aggttattgt cggcgtgaac aaataccagt tggaaaaaga ggatgcggtc     1500

gaggttctgg ctatcgacaa tacctcagtt aggaaccgcc aaatcgaaaa gcttaagaaa     1560

atcaagtcca gccgggacca ggcattagca gaaagatgcc tagccgctct cactgaatgc     1620

gcagcgtctg gagacggtaa catcctagcc ttggcagtcg acgcctcgag agccagatgc     1680

actgttggcg aaataactga cgcgctgaaa aaggtctttg gcgagcataa ggcaaatgat     1740

cgaatggtgt caggagctta cagacaagag ttcggtgaaa gcaaggagat cacttccgca     1800

atcaagagag tgcacaaatt tatggagaga gagggccgtc ggcctcgcct gctggtggct     1860

aaaatgggac aagatggcca cgatcgaggg gccaaggtaa tcgcaaccgg ctttgccgac     1920

ctcggcttcg atgtggatat aggccctctc ttccagacac ctagggaagt ggcccagcaa     1980

gccgtggacg ccgatgttca cgccgtggga gtttccaccc ttgcagctgg acacaaaact     2040

cttgtgcccg agctcattaa ggagttgaac agtctcggac gcccagatat cctggtaatg     2100

tgtgggggcg tcatcccccc tcaggactat gagttcctgt ttgaagtcgg agtgtcaaac     2160

gtctttggcc ccggaacaag gatcccgaag gctgctgtgc aggtcttaga cgacatcgag     2220

aagtgcctgg aaaaaaaaca gcaatccgtg                                      2250


<210>  48
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  48
atgctacgcg ccaaaaacca gctgttcctg ctgtcaccac actacctcag gcaagtgaaa       60

gaaagctccg gctctcggct catccaacag cgtctgctac accagcagca gccactgcac      120

ccagaatggg ctgccctcgc caagaagcag ctgaagggga agaatccaga ggatttgatt      180

tggcacacgc cggaagggat atccatcaag cccctttaca gcaaacgaga taccatggac      240

ttacctgaag agttgcccgg tgtaaagcct tttactagag gcccctatcc caccatgtac      300

acgttccggc catggacaat aaggcagtac gccggctttt ccacagtgga ggagtctaat      360

aagttctaca aggacaatat taaggccggt cagcaagggc tctcagttgc ctttgatctg      420

gccacccaca gagggtacga cagcgataat ccacgtgtta gaggcgacgt cgggatggcc      480

ggcgtcgcca ttgacaccgt cgaggatacc aaaatcttat tcgacggtat tcccctggaa      540

aaaatgagcg tgtcaatgac gatgaatggg gccgtcattc ctgttttagc aaatttcatt      600

gtgactgggg aggagcaggg ggtgcctaag gagaagctca caggtaccat tcagaacgac      660

atactgaaag agtttatggt gaggaacacc tacatctttc cccccgaacc ttccatgaag      720

atcatcgcgg acattttcga gtacacagca aaacacatgc cgaagttcaa ctccatttct      780

atctctggtt atcatatgca ggaagccggc gctgacgcta tcctggaact ggcatataca      840

ctcgcagacg ggctggagta tagcaggact ggcctgcagg ccggactgac catcgacgaa      900

ttcgcaccca gactgagctt tttttggggt attggaatga acttttacat ggaaattgca      960

aaaatgaggg cagggcgtcg tctgtgggcc catctcatcg agaagatgtt tcagcccaag     1020

aatagcaagt ctctgttgct acgcgcacac tgtcagacat ccggttggtc gctgaccgag     1080

caggatccat acaacaatat tgtcagaacc gccatcgaag caatggcagc cgtatttgga     1140

ggaacacagt ctctccatac caacagcttc gatgaggcat tgggtctgcc cacagtgaag     1200

tctgccagaa ttgctcgtaa cacacagatt attatacaag aggagtccgg tattccaaaa     1260

gtggccgacc catggggggg gagctatatg atggagtgct tgaccaatga tgtgtacgac     1320

gccgcgctga aactaatcaa cgagattgaa gagatgggcg gtatggctaa agccgtcgca     1380

gaagggatac ctaaacttcg aatcgaagaa tgtgccgccc gtagacaagc tcgcatcgac     1440

agtgggagcg aggtgattgt cggcgttaac aagtaccagc ttgagaagga ggacgcagtt     1500

gaggtccttg caatcgacaa cactagcgta agaaatcgtc agatcgaaaa attaaaaaaa     1560

atcaaatcaa gccgcgacca ggcactggcg gaacgctgcc tggccgctct gactgaatgc     1620

gcagcatccg gcgacggtaa tattttagca ctcgccgtgg acgcgtctcg tgcacgctgc     1680

actgtcggag agattacaga cgccctgaag aaagtttttg gagagcacaa ggctaacgac     1740

cgaatggttt caggggccta ccgccaggaa tttggggagt caaaagagat aacctctgcc     1800

ataaagagag tccataaatt catggaaaga gagggccgtc gacccagact tctcgtcgct     1860

aaaatgggtc aggacggaca tgacagggga gccaaggtca tcgcaaccgg attcgccgat     1920

ctcggctttg acgtcgacat tggcccgctc tttcagacac cccgagaggt ggcacagcag     1980

gcggttgatg cagacgtaca cgccgtcggg gtctccacac tagccgccgg acataaaact     2040

ctggttcctg aacttatcaa ggagcttaat agtctcggga ggccggacat cttggttatg     2100

tgtgggggcg tgataccccc acaagactat gagttcctct ttgaggttgg ggtatcaaat     2160

gtgtttgggc caggcaccag aattccaaag gccgcagttc aggtactcga tgacatcgag     2220

aagtgcttgg agaaaaagca gcagtccgtc                                      2250


<210>  49
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  49
atgctgcgcg ccaagaacca gctttttctg ctgtcgcccc actatcttag gcaagtgaag       60

gaatctagcg gcagcaggct catccaacag cggcttctgc accaacagca accgctgcat      120

cctgaatggg ctgccctggc taagaaacaa cttaaaggaa agaatcccga ggatttgatt      180

tggcatacgc ccgagggcat ttctatcaag cctctgtatt ccaaacgaga cactatggac      240

ctaccagagg agcttcctgg cgttaagccc tttacccgag gaccctaccc gaccatgtat      300

actttcaggc catggaccat tcggcagtac gccgggttct ccacagttga ggagtctaac      360

aagttctata aagataatat taaagctggc cagcaagggc tcagcgtcgc ttttgatctg      420

gctacacaca gagggtatga ttcagacaat cctcgggttc ggggagatgt cgggatggcc      480

ggggtggcta tcgacacagt agaagataca aaaatcctct ttgatggcat tcctctcgaa      540

aaaatgtccg tatctatgac tatgaacggg gccgtgatcc ccgtgctggc aaatttcatc      600

gttacaggcg aagaacaggg cgtgcctaag gagaagttga caggcacgat tcagaatgat      660

atattgaagg aattcatggt gagaaacaca tacatcttcc cacccgaacc cagtatgaag      720

attatcgctg atatttttga atacaccgct aaacacatgc ccaaattcaa tagcatttct      780

atatccggct accatatgca ggaggccggg gctgatgcca ttctagagct ggcatacacc      840

ctggctgatg gactggaata cagccggaca ggactccaag caggtctgac aatagacgag      900

ttcgctcccc gcttgagttt cttctgggga ataggaatga acttctatat ggagatcgct      960

aaaatgcgtg caggaagaag actttgggcc catctaatcg aaaaaatgtt tcagccgaag     1020

aatagcaagt ccctcctgct gcgcgcacac tgccagactt ctggttggag cctgacagag     1080

caagatcctt acaacaatat cgtgagaacc gctattgagg ctatggcagc ggttttcgga     1140

ggcactcaat cactacacac aaactctttc gacgaggccc tgggtctccc gaccgtgaag     1200

tcagcccgca ttgccaggaa cacacagatc attattcagg aagagagtgg catcccaaag     1260

gtggcggatc cttggggtgg atcatacatg atggagtgtc taaccaatga tgtgtacgac     1320

gctgcgttga aacttattaa tgaaatcgag gagatgggag gcatggctaa ggccgtcgcc     1380

gaggggattc ccaagctgcg aatcgaggaa tgcgctgctc gacgccaagc ccggatcgac     1440

agcgggagcg aagtgatcgt gggagtgaac aagtatcaac tggagaagga ggatgctgtg     1500

gaagtcttag cgatcgacaa tactagcgtg aggaatcggc aaatcgaaaa actgaaaaag     1560

attaagtctt ctcgcgacca ggccctcgct gaaaggtgtc tggcagctct gactgagtgt     1620

gccgctagcg gggacggaaa tattctcgcc ctggccgtag atgcctcccg ggcgcggtgc     1680

acggtcggcg agatcactga cgctctgaaa aaagtgttcg gcgagcataa agccaatgac     1740

cgaatggtta gcggtgctta tcgccaagaa ttcggggaga gtaaggaaat aacctccgct     1800

attaagcggg tgcacaagtt catggaacgg gagggcaggc ggcctcggct cttggtggca     1860

aaaatgggac aagatggtca cgacaggggc gccaaagtaa tagcaactgg atttgctgat     1920

ctcggctttg atgtcgacat cggtccactg ttccagaccc cacgggaggt ggctcagcag     1980

gccgtggacg ctgacgttca cgccgtggga gtgtctaccc tcgccgcagg acacaagaca     2040

ctggttccgg aattaatcaa agagctgaac tcgctcggac gccctgacat cctggtcatg     2100

tgtggcggcg tgattccccc gcaggattac gaattcttgt tcgaagttgg agtgtccaat     2160

gtcttcggcc ccggcactcg gattccgaag gcggctgtgc aggttctcga cgacatcgaa     2220

aaatgtctcg aaaagaaaca gcagtcagtc                                      2250


<210>  50
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  50
atgttacggg ctaaaaacca gttatttttg ttatctcctc attacctgag gcaggtgaaa       60

gagagcagcg gcagcaggct gatacagcag aggttactgc atcagcagca gcccttgcac      120

cctgaatggg cagccttagc caagaaacag ctgaagggca aaaatcccga agatttgata      180

tggcatactc ccgagggaat ctccattaag ccactgtaca gcaagagaga tacaatggac      240

ctgcccgagg agctcccagg cgtgaagcct tttacgaggg ggccataccc gaccatgtat      300

acgtttcgac cctggactat tcggcagtat gcaggatttt ccaccgttga ggaatccaat      360

aaattctaca aagataacat caaagctgga cagcagggcc tcagcgtggc ttttgatctg      420

gcaacccaca gaggatacga ctcagataat cccagagtga ggggcgacgt gggcatggct      480

ggagtcgcaa tagacacagt ggaagataca aagatcctgt ttgacggtat tccactagag      540

aagatgtccg tgtcaatgac aatgaatggt gccgtgatcc ctgtcctggc taactttatc      600

gtgacgggag aagaacaggg ggtccccaaa gaaaagctta ccgggacaat ccagaacgat      660

atcctcaagg aatttatggt tcggaacaca tacatcttcc ccccagagcc ttcaatgaaa      720

attatcgccg atatttttga gtacactgct aagcatatgc caaaattcaa ttccataagc      780

atttccgggt accacatgca ggaagccggc gccgacgcca tcttggagct ggcatatact      840

ctggcagatg ggctcgaata ctccagaacc ggactgcagg ccggcctcac catcgacgag      900

ttcgccccta ggctctcttt cttttggggc atcggaatga atttctacat ggagatcgcc      960

aagatgcggg ccgggcggcg cctctgggcg catcttatcg agaagatgtt tcagcccaag     1020

aattccaagt ctctgctcct tagagcccat tgccaaacta gcggctggtc cctcacagag     1080

caggacccat ataacaatat tgtgagaaca gcaatcgaag ctatggcggc tgttttcggc     1140

ggaacccaga gcctgcatac gaattcgttc gacgaagccc taggcctccc aacagtcaag     1200

agcgctagga ttgccaggaa cacccagatt ataatccaag aggagtccgg cattccaaaa     1260

gtcgctgatc cttggggtgg atcatatatg atggaatgcc ttacgaacga cgtgtatgac     1320

gccgccctca agctgatcaa cgaaatagaa gagatgggcg ggatggctaa ggccgtggca     1380

gaaggcatcc ccaagttacg gatcgaggag tgcgcagccc gtagacaagc cagaatcgac     1440

tctggctccg aagtcattgt cggggtaaac aagtatcagc tggaaaagga agatgcggtt     1500

gaggtcctgg ccatagacaa cacctccgtg cgaaacagac aaatcgaaaa gcttaagaaa     1560

atcaagagca gtcgcgatca ggccctggcc gaaaggtgcc tggcagccct taccgagtgt     1620

gcagcctccg gggacggcaa tatactggca ctggcagtgg atgccagtcg cgcacggtgc     1680

acagtcggag agatcactga cgcgttgaaa aaagtgttcg gggagcataa agctaacgac     1740

aggatggtct ccggtgctta taggcaggaa tttggtgaga gtaaagaaat aacatccgcc     1800

attaaaagag ttcacaagtt catggaacgg gagggaaggc gcccacgact cctagtggcc     1860

aaaatgggtc aggacgggca tgatcggggc gccaaggtca tcgcaacagg cttcgcagac     1920

ctgggcttcg atgtggatat tggaccgctt ttccagaccc ccagagaggt agcacagcaa     1980

gcggtggatg ccgacgtgca cgctgttgga gtatccaccc tagccgcggg tcataagacc     2040

ctggttcctg aactgattaa ggagttgaac agcctcgggc gccctgacat tctagtgatg     2100

tgcggaggcg tgatccctcc acaggactat gagttcctgt ttgaggtggg ggtctccaat     2160

gtgttcggtc ctggaacccg gattcctaaa gcagcagtgc aggtgctcga tgatattgaa     2220

aagtgtttgg agaaaaagca gcagagcgtt                                      2250


<210>  51
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  51
atgctgagag caaagaacca gcttttcttg ctctctcctc attacctgcg ccaggtgaag       60

gaaagctccg gcagcaggct gatccagcag cgtctactgc atcagcagca acccctgcat      120

cctgaatggg ctgctctggc aaaaaagcag ctgaagggta agaatcccga agaccttatc      180

tggcacaccc ccgaagggat cagcatcaag ccgttgtaca gcaagcgcga cactatggat      240

ctgcccgagg aactgcctgg cgtgaagcct tttacccggg gcccataccc taccatgtac      300

accttccgcc cctggactat tagacagtac gcaggttttt ccacggtgga ggagagtaac      360

aagttctaca aagataacat taaggcaggg cagcagggac tgagcgtggc cttcgatctc      420

gcaacccatc ggggatatga ctccgataac ccaagggttc ggggtgatgt gggtatggcc      480

ggcgtagcta tcgatacagt ggaagacaca aaaatactgt ttgatgggat cccgctggag      540

aagatgtcag tctcaatgac aatgaacggt gccgtgatcc ctgtgctcgc caacttcatc      600

gtgactggcg aggagcaagg tgtccctaag gaaaagctca ccggcaccat ccagaatgac      660

attcttaaag aattcatggt gagaaataca tacatcttcc cccctgaacc atccatgaag      720

attatcgctg atatctttga atacaccgcg aagcacatgc ccaagttcaa ttctattagt      780

atttctggat atcacatgca ggaggctggg gctgatgcca tattggagct ggcatacact      840

ctggccgatg gcttagaata cagcagaacg ggtctccaag ccgggctgac gatcgacgaa      900

tttgccccaa gactcagttt tttctggggg atcggcatga acttttacat ggaaatcgcc      960

aagatgcgtg cagggaggcg tctatgggcg catctgatcg aaaaaatgtt tcagccgaaa     1020

aatagtaaat ccctgctgct cagagcccac tgccaaacaa gcggctggtc tcttacagag     1080

caggatcctt acaataatat tgtgagaacg gctattgagg ctatggccgc tgtgttcggg     1140

ggtactcaaa gccttcacac caactccttt gatgaggccc tgggactgcc caccgtcaag     1200

tctgcccgga tcgctcggaa cacccagatc atcatacaag aggagtctgg tattcccaag     1260

gtcgctgatc cttggggcgg cagctatatg atggaatgtc taactaacga tgtgtacgat     1320

gcagccctca agctgatcaa tgagatagaa gaaatgggag ggatggctaa agctgtggcg     1380

gagggaatac ctaaattaag aatcgaagag tgcgcagccc gtagacaggc acgtatcgac     1440

tccggtagcg aggttatcgt cggtgttaat aagtaccagc tggaaaagga ggacgcggtt     1500

gaagtgttgg ctatagacaa tacgtccgtg cgaaaccgcc agatagagaa attaaagaag     1560

attaagtcat ccagagacca ggcccttgcc gagcggtgcc tagctgctct gactgagtgc     1620

gctgccagtg gggacggaaa tatactggcc ctcgctgtgg atgctagccg cgctcggtgc     1680

acagtaggag agatcactga cgcactgaag aaagtctttg gcgagcacaa ggctaatgac     1740

cgtatggtaa gtggggccta caggcaggag ttcggcgaga gtaaggaaat tacatctgcg     1800

attaaaagag tgcataaatt catggagaga gaagggcgga ggcctaggct gctcgtggct     1860

aagatgggtc aggatggcca tgacaggggt gcaaaagtga ttgccacggg gtttgcagac     1920

ctggggtttg acgttgacat aggtcctttg ttccaaacac ctcgcgaagt tgcccagcag     1980

gctgtggacg ccgacgtcca tgcagtgggg gttagcaccc ttgccgcagg gcacaagacc     2040

cttgtccctg agttgatcaa agaactgaat agtctgggaa ggcctgacat cctggtgatg     2100

tgcggaggcg tgatccctcc acaggactac gaattcctgt tcgaagtggg agtaagtaat     2160

gtctttggcc ccggaactcg aatcccgaaa gccgccgtgc aggtgctgga tgacattgaa     2220

aagtgcctgg agaagaagca gcagtctgtc                                      2250


<210>  52
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  52
atgctgagag ctaaaaacca gctcttcctc ctgtcacccc attacttgcg tcaggtgaaa       60

gagtccagcg ggtcccgact gatccagcag cggttactgc accagcaaca gccactgcac      120

ccagagtggg ctgcccttgc aaaaaagcag cttaagggca agaaccccga agaccttata      180

tggcacacac ctgaggggat ttctatcaag cctttgtata gcaaaagaga tactatggac      240

ctgccagaag agcttccagg cgtgaagccc ttcacccggg gcccctatcc cacaatgtac      300

accttccggc catggacaat tcgacagtat gccgggttta gcaccgtcga ggaatccaac      360

aaattctata aagataatat caaagctggc cagcaaggcc tgtctgtcgc cttcgacctt      420

gccactcaca gagggtatga ttctgataac cctcgtgtgc gtggggacgt gggcatggcc      480

ggagtcgcaa tcgacactgt agaagatacc aagattctct tcgatggtat cccattggag      540

aagatgagcg tctctatgac catgaatggc gcagtgatac cggttttagc aaacttcatc      600

gtgacaggcg aggagcaggg cgttcccaag gaaaagctca ccggtactat ccagaacgac      660

atccttaagg aatttatggt gcgaaacacc tacatctttc ctcctgaacc atccatgaaa      720

atcatcgcag atatcttcga atacactgca aaacacatgc ccaaattcaa tagcatctct      780

atatctggct atcacatgca ggaagccggg gccgacgcca tactggagtt ggcctatacc      840

ctggccgacg ggctcgaata cagccggaca ggattacagg ccggcctcac catcgacgag      900

ttcgccccaa ggctctcttt tttttggggg atcggtatga acttctacat ggagatcgca      960

aagatgcgcg cagggcgtag actgtgggca cacctcattg aaaagatgtt tcagccaaaa     1020

aattcaaaaa gcctcctact acgggctcac tgtcagacca gcgggtggtc tctgacggag     1080

caggatcctt ataacaatat agttagaacg gccatcgaag caatggccgc tgtcttcgga     1140

gggacacaat ctttgcatac taatagcttc gacgaggccc tcggactgcc cacagtgaag     1200

tcagccagga tcgcgcgaaa cacacagatt atcatccagg aagaaagcgg aatcccgaag     1260

gtggccgatc cctggggggg cagctacatg atggaatgcc tgacaaatga tgtgtacgac     1320

gctgcgttga agctaatcaa tgagatcgaa gagatgggcg ggatggcaaa ggccgtggcc     1380

gaaggcattc caaagttacg gatcgaggaa tgtgccgcac gcaggcaagc tcgtatagac     1440

agcggctctg aggtcattgt gggagtcaac aagtatcaac tggagaagga ggatgccgtt     1500

gaggtcctgg caatcgacaa tacaagcgtc agaaacagac aaattgaaaa actgaagaag     1560

atcaagagct ccagagatca ggcgctggca gagcgatgtc ttgcagcctt aactgaatgc     1620

gctgcctctg gcgacggtaa tattctcgcc ctcgcggtcg atgccagcag agctaggtgt     1680

accgtgggag aaattactga cgctctgaag aaggtgtttg gagaacataa ggctaatgat     1740

cggatggttt caggagccta tcgtcaggaa ttcggagaaa gtaaggagat tacgagtgct     1800

attaaacggg tacataagtt tatggagaga gaaggaagac gtccgagatt gctggtagcc     1860

aagatggggc aggatggtca tgatcggggc gctaaagtca ttgctactgg ctttgccgat     1920

ctggggttcg atgtcgacat tggaccactc tttcaaactc ccagggaggt agcgcagcag     1980

gccgttgatg cagatgtgca cgccgtgggc gtgtctactc tggccgccgg gcataagact     2040

ctggtaccag aactcatcaa ggagcttaac agcctaggac ggccagacat cttagtgatg     2100

tgtggcggcg ttatcccccc tcaggactac gaatttctgt tcgaagtggg agtgagcaat     2160

gtgttcgggc ctggcactcg aatcccaaag gctgcggtcc aggtcttgga cgacatcgaa     2220

aagtgcctgg agaaaaagca acagtccgta                                      2250


<210>  53
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  53
atgttgaggg caaagaacca actgttcctg ctgtcgcccc actacctcag acaggtcaag       60

gagtcatctg ggtccaggct gatacagcag aggctgctcc accagcagca gcctttacac      120

cctgagtggg ctgcacttgc taaaaagcaa ctgaagggta agaatccgga agatctgatt      180

tggcacactc cagagggcat atctatcaaa ccactctatt ccaaacggga cacgatggac      240

ctgccggaag agctgcccgg cgtcaaaccc ttcacccgag gaccataccc gacaatgtac      300

acatttaggc cctggacaat ccgccaatac gctggattta gcactgtgga ggagagcaac      360

aaattttaca aagacaacat taaagcgggc caacaaggtc tttctgtggc atttgatctc      420

gctactcata ggggctatga ctcagataac ccacgagtaa ggggggacgt tggaatggcc      480

ggcgtggcaa tcgataccgt tgaagatact aaaatactgt ttgatggtat tccactggag      540

aaaatgagcg tgtccatgac gatgaacggt gccgtgatcc ccgtgctagc caactttatc      600

gttacgggcg aagaacaggg agttcccaag gagaaattaa ctggtactat ccaaaacgac      660

attctgaagg agtttatggt ccgcaatact tacatctttc ctcctgagcc aagcatgaag      720

ataatagccg acatcttcga gtatactgca aagcatatgc caaagttcaa ttccattagt      780

atctcaggct accacatgca agaggcaggt gcagatgcta ttttggaact ggcttatacg      840

ctggcagatg ggctggaata cagcagaacg ggcttgcagg ccggcctgac catcgacgaa      900

tttgcgcccc gcttgagctt tttctggggg attggaatga acttctacat ggaaatcgct      960

aagatgcgag cgggccggcg actctgggct catctgatcg agaagatgtt ccagccaaaa     1020

aattcgaaat ctcttctctt gagagcgcat tgtcaaactt ccggttggtc cctgaccgag     1080

caggacccct ataacaacat cgtccgcact gctattgaag ccatggccgc cgtttttggt     1140

ggtacacaga gccttcacac aaactctttt gacgaagccc tgggattgcc cactgttaag     1200

tcagcgagaa tcgctcgaaa tacccagatt attatccagg aggaatcagg cattccgaag     1260

gtggccgatc catggggggg gtcctacatg atggagtgtt tgacaaacga cgtatatgac     1320

gcagccctga agttgatcaa tgaaatcgag gagatgggcg ggatggccaa ggccgtagct     1380

gaaggtattc ccaaactgcg aatcgaggaa tgcgcagcca gacgccaggc acgaattgac     1440

tcgggtagtg aggtgatcgt cggcgtgaac aagtaccagc tcgagaagga ggacgctgtc     1500

gaggtcttgg cgattgataa cactagcgtt cgaaatcgac agattgaaaa gttaaagaaa     1560

atcaagagct caagagatca ggccctggct gaaagatgtc tcgccgcact gactgagtgt     1620

gcagcttccg gagacggaaa tatcctggcc ttggcagttg atgcaagtcg tgccagatgc     1680

actgtgggtg aaatcacaga cgccttaaaa aaagtcttcg gagagcataa ggcgaatgac     1740

cgtatggtta gcggcgctta cagacaagag ttcggcgaga gcaaggaaat caccagcgca     1800

ataaaacgtg tgcataaatt catggaacgg gaaggccggc gtcctcggct gctcgtggcc     1860

aagatgggcc aggacggcca cgataggggc gccaaggtca ttgctaccgg gtttgctgac     1920

ctcggatttg atgtcgacat tggcccactt tttcagacgc ctcgggaagt cgcacaacaa     1980

gctgttgatg ctgacgtcca tgcagtgggt gtgagtacgc ttgctgccgg tcacaagaca     2040

ctggtccctg agctgataaa ggagttgaac tcccttggac ggcctgatat cctggtgatg     2100

tgcggaggcg tcatcccccc acaggactat gaattcttgt ttgaagtagg cgtgagtaac     2160

gtgttcggtc ctggaacaag aattccaaag gcagctgtgc aagtcctaga cgatattgaa     2220

aaatgccttg agaaaaagca acaatcggtg                                      2250


<210>  54
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  54
atgctccgag ccaagaatca actcttcctc ctctctccgc actatttgag acaagttaag       60

gagagctcag gctcccggct aattcagcag cgactcctgc atcagcagca gccactgcat      120

ccagagtggg ctgctctggc taagaagcag ctgaagggaa agaaccccga agacctgatt      180

tggcacaccc ctgaggggat tagtatcaag cctctctact cgaagagaga tactatggac      240

cttcctgagg agctgcccgg ggtcaaacca ttcaccaggg gaccatatcc taccatgtac      300

accttccggc cttggacaat taggcagtat gctggatttt ctaccgtgga ggagagtaat      360

aagttttata aggacaatat taaagctggt caacaaggat tgtccgttgc cttcgacttg      420

gccacccata gggggtatga cagcgacaat cccagggttc gcggagatgt cgggatggca      480

ggcgtggcca ttgatactgt cgaggatacc aagattttgt ttgacggaat cccacttgag      540

aagatgtccg tatctatgac aatgaatggc gctgttatcc ccgttcttgc caatttcatc      600

gtcaccggcg aggaacaggg agtgcctaag gagaaactta cggggactat ccagaacgat      660

atcctgaagg agttcatggt tagaaacact tatatattcc ctccagaacc gtcgatgaag      720

atcattgccg atatttttga atacactgcc aagcatatgc cgaaattcaa ctcaatcagc      780

atctcagggt atcacatgca ggaagcaggc gcagatgcga ttctggaatt agcatatact      840

ctggccgacg ggctggaata ctcacggaca ggtctgcagg caggcttgac catagacgaa      900

tttgccccca gactttcctt tttttgggga attggtatga atttttatat ggagattgct      960

aagatgagag ccgggcgcag actgtgggcc catctaatag aaaaaatgtt tcagcccaaa     1020

aacagcaaat ccctgcttct gagggcccac tgccagacaa gcggatggag tctgaccgaa     1080

caggatccat ataacaacat agtgcgaaca gcgatcgaag ctatggccgc cgtatttggg     1140

gggacccaga gtctgcacac caattccttt gacgaagcac ttggcctccc tactgtcaaa     1200

tctgcacgca ttgcccggaa cacacagatc atcattcagg aggagtctgg catccccaaa     1260

gtagccgacc catggggggg gtcgtacatg atggagtgtt taacaaacga tgtatatgac     1320

gccgccctga aattaatcaa cgaaatcgag gagatgggag gcatggctaa ggcagtggct     1380

gaaggaatac ccaagctccg aatcgaggag tgcgccgcgc ggcgacaggc gcgcattgac     1440

tctgggagcg aagtcatagt cggtgtgaat aagtaccagc tagagaagga ggacgcagtc     1500

gaggttttgg ccatcgataa cacatccgtg cgcaacagac agatagagaa attgaagaag     1560

atcaagtcct caagggatca ggctcttgcg gagcggtgcc tcgccgccct gactgagtgc     1620

gcagcatctg gcgacggcaa catcctcgcc ttggcagtgg atgcaagccg ggctcgatgt     1680

accgtgggcg agattacaga cgcacttaag aaagtgtttg gagagcataa agcaaacgat     1740

cgcatggtga gtggcgctta cagacaggag ttcggcgagt ccaaagaaat cactagcgcc     1800

atcaaacggg tccacaagtt catggaaagg gaaggcagaa ggcctcgtct cctcgtcgcc     1860

aagatgggcc aggatgggca cgaccgcgga gccaaggtga ttgctactgg ctttgcggat     1920

cttgggtttg acgttgatat tgggccgctt tttcagactc caagagaggt tgcccagcag     1980

gctgtcgatg ctgatgtcca cgccgtgggc gttagcaccc tggctgccgg tcataagacc     2040

ctggtaccag aattaataaa ggaacttaac agccttgggc gcccggatat tctagttatg     2100

tgcggtggtg ttatccctcc ccaagactat gaattcctgt ttgaagttgg agttagcaac     2160

gtgtttggtc ctgggacaag aattcctaag gccgcggtac aggtcctcga cgatatcgaa     2220

aagtgtctcg aaaagaagca acagagcgta                                      2250


<210>  55
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  55
atgttgcggg ccaagaatca actgttcctt ctttctcctc actacttacg gcaagtgaag       60

gagtcttccg gatccaggct aattcaacaa cggctcctgc atcagcagca gcctctgcac      120

ccggagtggg ccgcccttgc caaaaaacag ctcaaaggta agaacccaga ggatctgatc      180

tggcacaccc ccgaaggcat cagtatcaag cccctgtata gtaaacggga cacaatggac      240

ctgccggagg agctgccggg agtcaagccc tttactcggg gtccataccc cacaatgtac      300

acttttcggc cttggactat ccgccagtat gccgggttca gcaccgtaga agaaagtaac      360

aaattttaca aggacaatat taaagcaggg caacagggtc tgtcagtggc atttgacctg      420

gccactcaca gagggtatga ctctgataac ccccgcgtga gaggcgatgt aggcatggca      480

ggtgttgcca ttgacacggt cgaagatacg aaaatcttgt tcgatggaat ccccctcgaa      540

aaaatgtcag tgagcatgac tatgaacgga gccgtaatcc ccgtgctggc taatttcatc      600

gtaaccggcg aggagcaggg cgtccccaag gagaaactga ccggcacgat acagaatgac      660

atcctgaagg agtttatggt ccgtaacacc tacatattcc cacccgaacc gtcgatgaaa      720

attatcgctg atatatttga atacacggcc aagcacatgc ctaagttcaa ctccattagc      780

atctctggct accacatgca agaagcaggg gctgacgcca tcctggaact cgcctacaca      840

ctggctgatg gacttgaata ctctagaacc ggtctgcaag ctgggttgac gatagatgag      900

tttgctccca ggctctcatt cttctggggc ataggtatga atttctatat ggagatagct      960

aaaatgaggg ccggtaggag gctgtgggcc caccttatcg aaaaaatgtt ccaaccgaag     1020

aatagcaagt ctcttttgct gcgcgcccac tgccagacca gtggctggtc acttacagaa     1080

caggatccat acaacaacat tgtcaggact gccatcgaag ccatggccgc ggtttttgga     1140

ggaacgcaat ccttacacac gaacagcttt gacgaggctt taggcttacc cacggtgaag     1200

agcgctcgga tagcaagaaa cacccagata attattcaag aggaatcagg gattccgaag     1260

gtagcagacc cttggggcgg ttcctacatg atggagtgcc tcactaacga cgtctacgat     1320

gccgctctta aactcattaa tgagatcgag gagatgggcg gaatggcaaa agcagtcgcc     1380

gaagggatcc caaagctcag aattgaggag tgtgccgctc gtcggcaagc aaggattgac     1440

tcaggcagcg aggtcatcgt cggggttaat aagtaccagc tcgagaaaga agacgctgtg     1500

gaggtgctcg ctattgacaa taccagcgtg cggaaccgtc agatagagaa attgaagaaa     1560

ataaagtcca gccgagacca ggcgctggca gaaaggtgtc tggctgccct aacagagtgt     1620

gccgcgtctg gcgacggcaa catcctggct ctggcagtgg atgcaagtag ggcgaggtgc     1680

acggtggggg agatcactga tgccctcaag aaggttttcg gggagcacaa ggccaacgac     1740

cggatggtga gcggagcgta ccgacaagaa ttcggtgagt ctaaggagat tacctcagcc     1800

atcaagagag ttcacaaatt tatggagaga gaggggagac ggcctcgcct cctggtggct     1860

aaaatgggac aagacggtca cgaccgagga gctaaggtga ttgcaaccgg ctttgcagac     1920

ctggggttcg acgtggatat cggccctctg tttcaaacgc ctagggaagt cgcccagcaa     1980

gccgtggacg ctgatgtgca tgcagtggga gtgtcaactt tggccgccgg acacaagacc     2040

ttggtccccg aactgatcaa agagctgaat tccttgggaa ggcccgatat acttgttatg     2100

tgcggcgggg tgattcctcc gcaggactat gagttcctgt ttgaggtggg ggtgagcaac     2160

gtcttcggac ccggtaccag aatcccaaag gcagctgtgc aggttttgga tgatattgag     2220

aagtgtctcg agaagaaaca gcagtcggtg                                      2250


<210>  56
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  56
atgctccgcg ccaaaaatca gctcttcctc ctcagccccc attatctccg ccaagtgaag       60

gaatctagtg gaagcaggct gatccagcag cggctgctcc atcaacagca gccccttcac      120

cctgagtggg cagccctggc caagaaacag ctgaaaggaa aaaaccccga agatctgatc      180

tggcatacac cagaggggat atcaatcaag ccattgtata gcaaaagaga tacgatggat      240

cttccagaag agctgcccgg tgtcaagccc tttaccagag gcccctaccc taccatgtat      300

acttttcgtc cttggactat ccggcagtat gctggcttta gcactgtgga ggagtcaaac      360

aagttctaca aagacaatat aaaagcagga cagcaaggcc tttctgtcgc ctttgacctc      420

gccactcaca ggggctatga tagcgacaac ccaagagtaa gaggtgatgt aggcatggcc      480

ggagtggcta ttgacactgt ggaggataca aaaatcctct ttgatggcat ccctctggag      540

aaaatgtctg tgtccatgac catgaacgga gccgtgatcc ccgtcctggc aaacttcatc      600

gtcacggggg aagaacaagg cgtgccaaaa gagaagctga ccgggaccat tcagaacgac      660

attctgaaag agtttatggt tcggaatacc tacattttcc ccccagaacc atccatgaag      720

atcattgccg atatcttcga gtatactgca aaacacatgc caaaatttaa ctccattagc      780

atctccgggt accatatgca ggaagctgga gcggacgcta ttctcgagct tgcatacacc      840

cttgcggatg gactcgagta ctctcgcaca ggcctccagg ctggcctgac aatcgatgag      900

ttcgctccac ggctgagctt cttctggggg atcggaatga atttttatat ggagatagct      960

aaaatgcggg cggggcggcg tttatgggca cacctgatcg aaaagatgtt ccaacctaag     1020

aactccaagt ccttgctgct tcgagcccac tgtcagacct caggatggtc tttgaccgag     1080

caagaccctt acaataatat tgtccgtacc gctatcgagg ccatggccgc cgttttcgga     1140

ggcacgcagt cactccatac taatagcttt gatgaggctc tgggactgcc aacggtgaaa     1200

tccgcccgga tagcccgtaa tactcaaatc ataatacagg aggagtcagg aattcccaaa     1260

gtggccgacc cttggggagg aagctacatg atggaatgcc ttaccaatga cgtgtacgac     1320

gctgccctga aactgattaa tgagattgaa gagatggggg ggatggcaaa agctgttgcc     1380

gagggtatcc cgaaactgag gattgaggag tgcgctgcaa ggcgtcaggc cagaattgat     1440

tccgggagtg aagttatcgt gggggtgaat aagtaccaac tagagaaaga agatgcggtc     1500

gaggtcctgg cgatcgacaa tacaagcgtt cgcaatcggc agatcgaaaa attgaagaag     1560

ataaagtctt caagggatca ggctctggca gagcggtgtc tggccgccct cactgagtgt     1620

gccgcatcag gcgatgggaa catactggct ctagcagtgg acgccagccg tgctcggtgc     1680

actgtggggg aaattactga tgctctcaag aaggtgttcg gagagcacaa ggcaaacgat     1740

cgcatggtgt ctggtgcata cagacaggag tttggcgagt ctaaggagat cacgtctgct     1800

attaagaggg tgcataaatt tatggagagg gaggggcgcc gccctcggct gctcgtcgcc     1860

aaaatgggcc aggatggaca tgatagggga gccaaagtga tcgctactgg atttgccgat     1920

ttagggtttg acgttgatat agggccactc ttccagaccc ctagggaagt cgctcagcag     1980

gccgtagatg ccgacgttca cgctgtgggc gtgtctaccc tggctgccgg acacaaaacc     2040

ttggttcctg agctaattaa agagcttaat tccttaggtc gaccagacat tctggtgatg     2100

tgtggtggag tgataccccc tcaggactac gagtttttgt ttgaggttgg cgtttcgaat     2160

gtgttcgggc ccggtacacg cattcccaaa gcagctgttc aggtgctgga cgacattgag     2220

aaatgtcttg agaagaagca acaatccgtg                                      2250


<210>  57
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  57
atgctcaggg ccaaaaacca gctttttctc ctctccccac attaccttag acaagtgaag       60

gaatcctccg gatccaggct tatccagcaa aggctcttgc accagcagca gccgctgcat      120

cccgaatggg cggccctcgc aaagaagcag ttaaagggca aaaaccccga agatctcata      180

tggcacaccc cggagggtat ctccataaag cccttgtatt caaagcgcga tacgatggac      240

ctgccagagg aactgccggg ggtgaagcca tttactagag ggccatatcc caccatgtat      300

accttcaggc cctggaccat ccgacagtac gctggcttct ccaccgtgga ggagagcaat      360

aaattttata aagacaacat aaaagccggc cagcaaggac tctcagttgc gtttgacctt      420

gccactcacc gtgggtacga ttccgataat cctagagtaa ggggggacgt gggcatggcg      480

ggggtggcaa ttgataccgt tgaagacact aagattttgt ttgatggcat ccctctggag      540

aagatgtccg tttccatgac tatgaacggt gctgtcatcc cagtgctggc caatttcatt      600

gtgactggcg aagagcaagg ggtacccaag gaaaagctga cgggaaccat ccagaacgac      660

atcctcaagg agttcatggt gcgcaacacc tacatctttc caccggagcc ctcgatgaaa      720

ataatcgccg acattttcga gtatactgcc aagcatatgc ctaaatttaa ttccattagc      780

atcagcggct accacatgca ggaagccggt gcagacgcca ttctggagct cgcctacact      840

ctcgctgacg gactggagta tagcaggacc ggcctccagg cgggcctgac gatagacgag      900

ttcgcaccca ggctatcatt cttctggggt atcggcatga atttctacat ggaaattgcc      960

aagatgaggg caggcaggcg cctgtgggcc cacttaattg agaagatgtt ccagccaaag     1020

aattcaaaga gtctgctatt gcgggcccat tgtcagacct ctggctggtc gctgacagaa     1080

caggatccat ataacaacat tgtgcgcacc gccatcgaag ctatggcagc cgtttttgga     1140

ggaacccagt ccctgcacac aaattctttt gatgaggctc tgggcctgcc gactgtcaaa     1200

agtgcgagga tcgccaggaa cactcagatt attattcagg aggaatcggg tatcccgaaa     1260

gtcgccgatc cctggggagg atcttatatg atggaatgcc tgaccaacga cgtgtatgac     1320

gcagccctta aattgataaa cgagatcgag gaaatgggag gtatggcaaa ggcggtggcc     1380

gaagggattc ccaaactcag gattgaggag tgcgccgccc ggagacaggc acgcatcgat     1440

tccgggtccg aagtgatagt aggagtgaac aaataccaat tggaaaagga ggacgccgtg     1500

gaggtcctcg ccattgacaa tacgagcgtg cgcaacaggc agatagagaa gttgaagaag     1560

attaaatcta gccgtgacca ggcactcgcc gagcgatgcc tagcagctct tacggagtgt     1620

gccgccagcg gagatggcaa catccttgct ctcgccgtcg atgcaagtag agcaagatgt     1680

accgtcggcg agataactga tgccttaaag aaggtttttg gcgagcacaa ggcaaatgac     1740

agaatggtct caggcgcata tcggcaagag ttcggagagt ccaaagagat cacgtctgcc     1800

atcaagaggg tacacaaatt catggagagg gaaggaagaa gaccacgact gctggtcgct     1860

aagatgggcc aggatggtca cgaccgcggc gcaaaagtga tcgcaacagg gtttgctgac     1920

ttgggctttg acgtggacat aggaccttta ttccagacgc cgcgggaagt ggcacagcag     1980

gctgtggatg cagacgtgca tgcagtggga gtgtcaaccc tggccgccgg gcacaagacc     2040

ctcgtgccgg agctgattaa ggaactgaac tccctaggcc ggcccgatat tctcgtgatg     2100

tgcggcggcg tcatacctcc tcaagactac gaattcctgt tcgaagtagg agtcagcaac     2160

gtttttgggc cagggacaag gatcccaaag gcggctgttc aagttttaga tgacatcgag     2220

aaatgcctcg agaaaaaaca acagtcagtt                                      2250


<210>  58
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  58
atgctgaggg caaaaaatca actctttctt ctgtccccac actacctgcg tcaggtaaag       60

gagagttccg gtagcagatt gatccagcag agactgctcc atcagcagca gcctctgcat      120

cccgagtggg ccgctctggc taaaaaacag ctgaagggga agaatcccga ggacttgatc      180

tggcataccc ctgagggaat ctccatcaag cctctataca gcaagcggga cacgatggat      240

cttccagaag agctgcctgg agtgaagcct ttcaccagag ggccgtaccc tacaatgtac      300

acatttcgcc cctggactat tcgtcaatac gctggcttta gtacagtgga ggaaagcaac      360

aagttttaca aagataatat caaggctggc cagcaaggcc tgtcagtcgc ttttgacctt      420

gctacccatc gggggtatga cagcgataac ccccgcgtga gaggagatgt tggaatggcc      480

ggtgtggcca tagatacagt ggaagatacg aagattctct tcgatggtat cccactggaa      540

aaaatgtctg tgagcatgac catgaatgga gctgttattc cggtgcttgc taattttatt      600

gtgactggag aggagcaggg agtgccaaaa gaaaagctca cgggcacaat tcagaacgac      660

attttaaagg agttcatggt cagaaacacc tatatcttcc cccccgagcc ctcaatgaaa      720

attattgctg acattttcga gtatacggca aagcatatgc caaagttcaa ctctatttcc      780

atctctgggt atcatatgca ggaggctggc gccgacgcca tcctcgagtt ggcatacaca      840

ctcgcggacg gccttgagta ctcacgaact ggcctccagg cagggttgac tatcgacgag      900

tttgccccaa ggttgtcatt cttttgggga attggaatga acttttatat ggaaatcgca      960

aaaatgaggg ccggaagaag gttgtgggcc catctcatcg aaaagatgtt tcaaccaaag     1020

aacagtaagt cactgctgct ccgggcccat tgtcagacca gcggatggtc actaactgag     1080

caagaccctt acaacaatat tgtgcgaact gccatcgagg ccatggctgc cgtgttcggc     1140

ggaactcaga gtctgcacac taacagcttc gatgaggcac tcggcttgcc aaccgtgaag     1200

tctgccagga tcgctaggaa tactcaaatc atcattcaag aagagtcagg gataccgaaa     1260

gtagcggacc catggggtgg ctcttacatg atggaatgcc tgaccaatga cgtgtacgac     1320

gccgctctca agctcattaa tgagatcgaa gagatgggag ggatggccaa agcggtcgca     1380

gaaggaatcc ccaagctacg catagaagag tgtgctgcac gccgtcaggc gagaatcgat     1440

agtgggtctg aagtcatcgt gggcgttaat aagtaccagt tagagaaaga ggatgcagtc     1500

gaagttctgg ccatagacaa tacttctgta cgcaatagac agatcgagaa attgaagaaa     1560

atcaaatctt caagagatca ggcgctggca gaaaggtgtc tggccgctct gacggagtgt     1620

gccgcttccg gcgatggcaa tatacttgca ctcgccgttg acgcgagtcg ggcacgctgc     1680

accgttggcg agattactga tgccctcaag aaggtctttg gggagcacaa ggcaaacgac     1740

cgcatggtaa gcggagccta cagacaagaa tttggggaga gtaaggagat tacatccgct     1800

attaagagag tacacaagtt catggaaagg gaaggacggc gtcctcgcct gttggtggca     1860

aaaatggggc aggatggtca cgacagaggg gctaaagtaa ttgccacagg ctttgctgat     1920

cttggatttg acgttgatat cggcccactg tttcagaccc cccgcgaagt tgcccagcag     1980

gcagtggatg ctgacgtgca cgcagtcggc gtgagcaccc tggcagccgg gcacaaaact     2040

ctggtcccag agctcattaa ggagctcaat tcactcggcc gccccgacat tctcgtaatg     2100

tgcggaggag tgatacctcc ccaggattac gaattcctgt tcgaagttgg ggtctccaac     2160

gtctttggcc caggcacaag aatcccaaag gccgctgtgc aggtactaga tgatatcgag     2220

aagtgccttg aaaagaagca acagtctgtt                                      2250


<210>  59
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  59
atgctcagag ccaaaaatca gctcttcctg ctgagcccac actacttacg tcaagtgaaa       60

gagagctctg gcagcagact gattcaacag cggcttctcc atcagcaaca gccactccac      120

cccgaatggg cagccctggc caagaaacag cttaagggga aaaatccaga ggatcttatt      180

tggcacactc cagagggcat tagtatcaag cccttatatt caaagagaga taccatggat      240

ctccccgaag agcttccggg tgttaagcct ttcacgaggg gcccataccc tacaatgtac      300

acgttccgac catggaccat ccgacagtac gctggtttct ctaccgttga agagtccaac      360

aagttttata aagacaatat taaagccggc cagcagggcc tcagcgtggc atttgacctc      420

gctacccatc ggggctatga ttcagacaac ccaagggtgc ggggcgacgt cggaatggcc      480

ggggtggcaa ttgatacggt agaggatact aaaatcctct tcgacgggat cccccttgag      540

aaaatgagcg taagtatgac catgaacggc gccgtgattc cggttctcgc taacttcatt      600

gtgacaggtg aggagcaagg tgtccctaaa gaaaagctca ccggaacaat tcagaacgac      660

attctcaagg agttcatggt gaggaataca tacatctttc ctcccgagcc aagcatgaaa      720

attattgctg atatcttcga atacaccgcc aaacatatgc ctaaattcaa ttcgatttct      780

atctccggtt accacatgca agaagccggg gccgatgcca ttctggagct ggcttacacg      840

ctagcggacg gtttagaata ttcccgtaca ggcttgcagg ctgggctgac catcgacgaa      900

tttgccccca ggctctcttt cttctggggg atcggcatga acttttatat ggaaatcgct      960

aagatgcgtg ccggaagaag actctgggcc cacttaatcg agaaaatgtt ccagcctaaa     1020

aattctaaaa gccttctgct gagggcgcat tgtcagacaa gtgggtggtc tttgacagag     1080

caggatccct acaataatat cgtgagaaca gccatcgaag ctatggccgc ggtcttcggc     1140

ggcacacaga gcctgcatac caatagcttt gatgaagccc taggtttacc tacagtaaag     1200

tccgcgagaa tcgctcgaaa cacccagatc atcattcagg aagagagtgg tataccaaag     1260

gtggccgatc cttggggcgg ctcgtacatg atggaatgct taaccaatga cgtgtacgat     1320

gccgctctta aactcattaa cgagatagag gagatgggag gcatggctaa agctgtcgcc     1380

gaaggtatcc ctaaactccg gattgaagaa tgcgctgccc gcagacaggc tcgtatagat     1440

tcaggctccg aggtgattgt cggcgtgaac aaataccagc tggagaagga ggacgccgtc     1500

gaagtgctgg caattgacaa tactagcgtc cgcaataggc aaatcgaaaa gttgaaaaag     1560

atcaaatcct cacgggatca ggcgctggca gagagatgtc tggctgcctt gaccgagtgc     1620

gctgccagtg gtgacggtaa cattctggca ttggccgtgg atgcatcacg tgcccggtgc     1680

actgtgggag agatcaccga cgccctgaag aaggtattcg gcgagcataa ggcaaacgat     1740

cgaatggttt caggtgctta caggcaggaa ttcggagagt caaaagaaat tacgagtgca     1800

atcaagaggg tccataaatt tatggaaagg gagggcagaa ggcctcgctt actggttgct     1860

aaaatggggc aggacgggca cgatcgcgga gctaaggtga ttgccacagg atttgcagac     1920

ttaggttttg acgtggacat tgggccctta ttccagaccc cccgcgaagt ggctcagcaa     1980

gctgtggatg cagatgtcca cgccgtaggg gtgagcactc ttgccgccgg gcacaaaaca     2040

ctggtgccag agctgatcaa ggagctgaac tccctgggcc gacctgacat attagtcatg     2100

tgcggaggag tcattcctcc gcaagattat gaatttctgt tcgaggttgg ggtgtccaac     2160

gtctttggac cagggactag aatcccaaaa gccgctgttc aggtgctgga cgatattgaa     2220

aaatgtttag aaaaaaaaca acagtctgta                                      2250


<210>  60
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  60
atgctaaggg ccaaaaatca acttttcctg ctgagcccgc actatttaag gcaggttaag       60

gaatcctcag gttccaggct gatacagcag cggttgctcc atcagcagca acctttgcat      120

cccgagtggg ctgctctggc gaaaaagcag ttaaaaggca aaaatccaga ggacctcatc      180

tggcatactc ctgagggcat ctctattaag cccctgtatt ccaaacgcga tacaatggat      240

cttcccgaag aattgccagg tgttaagcca ttcactaggg ggccttaccc taccatgtac      300

acgtttcggc cttggacgat ccgccagtat gcaggattta gcaccgtgga ggagtctaat      360

aaattctaca aagataacat taaagcgggc cagcaaggtc tgtccgtagc cttcgatttg      420

gccacccatc gagggtacga ttccgacaat cctcgggtgc gaggtgacgt agggatggcc      480

ggggttgcca ttgatactgt tgaggatact aaaatactct tcgatgggat cccccttgaa      540

aaaatgagcg tgtcgatgac aatgaatggg gctgtgatcc ctgtcctggc taactttata      600

gtgacaggag aagagcaagg agtcccaaag gaaaaactca ctgggacaat tcagaatgac      660

atactcaagg agtttatggt gcgaaataca tacatcttcc ccccagagcc ctccatgaag      720

atcattgctg acatcttcga gtataccgct aaacatatgc ctaaattcaa cagcatatca      780

atctccgggt atcacatgca agaggccggg gcagatgcaa tacttgagct cgcgtataca      840

ctggccgatg gccttgagta tagcagaacc gggctccagg ccggcctgac tattgatgaa      900

tttgcgccac gtctctcctt tttctgggga atcgggatga atttctacat ggagatcgcc      960

aaaatgcgcg ccggtaggcg gctgtgggct cacctgattg agaagatgtt ccagcccaag     1020

aatagcaaga gccttctgct cagagctcat tgccagacct caggatggag cttaacggaa     1080

caggatccgt acaacaatat cgtgcggaca gcaatcgagg caatggccgc cgttttcggt     1140

ggcacccaat cactgcatac taactcgttc gatgaggcgc taggcctccc tacagtgaaa     1200

agcgcaagga tcgccaggaa cactcagata ataatccagg aagaatctgg catccctaag     1260

gtggctgacc cctggggagg ttcttacatg atggagtgcc tgactaatga cgtttatgat     1320

gccgcgctga aacttatcaa cgagattgaa gaaatgggag gaatggccaa ggctgtcgct     1380

gaaggcatcc ccaagctgag gatcgaagag tgtgcagcac ggaggcaagc caggatagat     1440

agtggcagcg aagtcatcgt tggcgtgaat aagtaccagc ttgagaagga agatgcagtt     1500

gaagtcctcg ccattgacaa cacctctgtg cggaaccgtc agatcgaaaa actgaagaag     1560

atcaaaagct ccagagacca ggccttggcg gaaagatgtc tcgcggcatt gacagagtgc     1620

gcggcttctg gggatggtaa catcctggcc cttgccgttg acgcatctcg ggccagatgt     1680

actgtcggag aaattaccga cgccttgaag aaggtgttcg gagagcacaa agcaaatgac     1740

cggatggtca gcggtgccta caggcaggag tttggcgaaa gcaaagaaat aaccagcgcc     1800

ataaaacgtg tccataaatt catggaacgg gagggccgac ggcctcgcct cctggtggcc     1860

aagatgggcc aggatggcca cgataggggg gctaaggtta tcgctaccgg ttttgctgat     1920

cttggattcg atgttgacat cggcccactg ttccaaaccc ctcgagaggt ggctcaacag     1980

gccgtggatg ccgatgttca cgcagttggc gtaagcacct tggccgcagg ccacaaaacg     2040

ctggtgccag aactcatcaa agagttgaac agtctgggac ggcccgacat actggtaatg     2100

tgcggcggag tgatcccacc tcaagattac gagttcttat ttgaggtggg tgtgagcaat     2160

gtgttcggac ccggcacccg gatcccaaaa gccgccgtcc aggttctcga tgatattgaa     2220

aagtgcctcg aaaaaaagca acaatcggtt                                      2250


<210>  61
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  61
atgcttcgtg ctaaaaatca gttatttttg ctctcaccac actacctgcg gcaggtgaaa       60

gaatctagcg ggtcccgcct gatccagcaa cgactgttgc atcaacaaca gcccctccat      120

cctgaatggg ctgctcttgc aaagaaacag cttaagggta aaaatccgga agatttgatc      180

tggcacacac cagagggcat ttctattaag cctttgtatt caaaaaggga tactatggac      240

ttacccgagg agctgcccgg agtcaaaccc ttcacccgtg gcccgtatcc caccatgtat      300

actttccggc cgtggaccat taggcagtac gcagggttct ccaccgtcga agaatcaaat      360

aagttctaca aggataatat caaagctggt caacagggct tatctgtggc tttcgatctc      420

gccacccaca gagggtatga cagtgacaat cctcgcgtgc gaggagatgt cgggatggct      480

ggcgtcgcta tcgacactgt ggaggataca aagatactgt ttgatggcat tccactcgag      540

aaaatgagcg tgtccatgac tatgaatggt gccgtgattc ctgttctggc taattttatc      600

gtgacaggag aggagcaagg tgtgcccaag gagaagctca ccggtaccat ccagaacgac      660

atcctcaagg aattcatggt ccggaatact tacattttcc ccccagagcc atccatgaag      720

atcatcgccg acatcttcga atacaccgca aagcacatgc cgaagttcaa ctctataagt      780

atctccggct accacatgca agaagccgga gccgatgcca tcttggagct tgcatatact      840

ttagctgatg gactggaata ttctcgtacg gggctgcagg ctggcctgac catagacgag      900

ttcgcgccac gactgtcatt tttctggggc attggaatga atttttatat ggagatcgcc      960

aagatgcggg ccggtagacg gctgtgggct cacctgattg aaaaaatgtt ccaaccaaaa     1020

aactctaaga gcttgttgct gagggcgcac tgtcagactt caggctggag tcttacagag     1080

caagaccctt acaacaacat cgttagaaca gctattgaag ccatggctgc tgtatttgga     1140

ggcacccaat ccctccacac caactcattc gatgaggccc tgggcctccc gacagtcaaa     1200

tccgccagaa tcgctaggaa cacacaaata attattcagg aagagagcgg aatcccaaag     1260

gtggcagacc cttggggggg cagctatatg atggagtgcc tgactaacga cgtctacgat     1320

gccgccctta aactgattaa tgaaatcgaa gagatgggtg gcatggctaa ggcggtggcc     1380

gaaggcatcc caaaactgcg catagaggaa tgtgccgccc gccggcaggc gaggatcgac     1440

tcgggaagcg aggtgattgt tggggtgaat aaataccaac tggaaaaaga ggacgccgtt     1500

gaggtcctgg caatagataa cactagtgtg cgtaaccggc agattgagaa gcttaaaaag     1560

atcaagtcct ctagagacca agccctggcg gaacgttgtc tggccgccct gacagaatgt     1620

gcggcaagcg gggatggaaa tattctggca ctggcagtgg atgcttcccg agctcgttgt     1680

accgtcgggg agatcacgga cgccctgaaa aaagtgttcg gcgagcacaa ggctaatgac     1740

agaatggttt caggcgctta taggcaggaa tttggtgaga gtaaggagat tactagcgct     1800

attaaacggg ttcataagtt catggaacga gaaggtcgac ggcctagact actggtagct     1860

aaaatgggcc aagacggcca cgacagaggg gccaaggtca ttgcgactgg ctttgccgat     1920

ttgggcttcg acgtcgatat cggaccactt ttccagacgc ctcgagaggt agcacagcaa     1980

gcagtcgatg ccgatgttca tgccgtggga gtgagcacac tggcagcggg ccacaaaaca     2040

ctagtgcccg aactgatcaa ggagctgaat tccctcggca gaccagatat cctagtaatg     2100

tgtggcggcg ttattcctcc acaggactac gaattcctat ttgaggtcgg cgtcagtaac     2160

gtgtttgggc ctggcactcg tattcccaaa gcagcggtgc aggttctaga cgatattgag     2220

aagtgcctgg aaaaaaagca acaaagcgtg                                      2250


<210>  62
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  62
atgctccgtg ctaaaaatca gctttttctg ctatcccccc actatctgag acaggttaaa       60

gaatcgtctg gctccagact gattcagcag cgccttcttc accagcagca gccattgcac      120

cccgagtggg ctgcgctcgc caaaaaacag ctgaagggga aaaaccctga ggacttaatc      180

tggcataccc cagaaggtat cagcataaag cccctgtata gcaaacggga tacgatggac      240

ctgcctgaag aactgccagg cgtgaagccg tttaccaggg gtccataccc caccatgtat      300

acctttcgcc cttggactat ccggcagtac gcgggattct ctacagtgga ggagagtaat      360

aaattttaca aggataatat aaaggcaggc caacaggggc tgtctgtcgc ctttgacttg      420

gccacgcaca gagggtatga ttccgataac ccgcgcgtgc ggggcgatgt gggcatggct      480

ggcgtcgcta ttgacacagt ggaggacaca aaaatactct ttgatggtat ccccttggag      540

aaaatgagcg ttagtatgac tatgaacggg gcagtgatcc ctgtgctcgc caatttcatc      600

gtgacaggcg aagagcaggg cgtgcctaaa gaaaaactga ccggaaccat ccaaaatgat      660

atcctgaagg agtttatggt gcgaaacacc tatatctttc ctcctgagcc cagtatgaaa      720

attattgctg acatattcga atacacagct aaacacatgc ccaaatttaa ctcgatttct      780

atatcaggtt accacatgca agaggctggt gctgatgcta tcctcgagct cgcgtatact      840

ctcgcagatg gccttgagta ctcacgcacc ggactccagg ccggtctcac tatcgacgag      900

ttcgccccac gcctgagctt tttttggggc atcgggatga atttttacat ggaaattgcc      960

aagatgcgag ccggaagacg gttatgggcg cacctgattg aaaaaatgtt ccagcctaag     1020

aatagtaaaa gtttgctact gcgcgctcac tgccagacaa gcggatggtc tcttactgag     1080

caggatccat acaacaacat cgtgcgcact gctatcgaag ctatggctgc agtgtttggc     1140

ggaactcaat ccctccacac aaactccttc gacgaagccc tgggcctgcc aacagtgaag     1200

tccgctagga tcgctcggaa tacccaaatc atcattcagg aggaatctgg tattcccaaa     1260

gttgctgatc cttggggtgg ctcctacatg atggaatgtt tgacaaacga cgtgtacgat     1320

gctgcgctta aactgattaa cgaaatcgaa gagatggggg gcatggctaa agcagtggct     1380

gagggcattc caaaactccg cattgaggag tgtgcagctc gacggcaagc ccgaattgac     1440

tcgggtagcg aagttattgt gggcgtaaac aagtaccaac tggagaagga ggacgctgtt     1500

gaagtcctag cgattgataa cacctccgtc cgtaacagac aaattgagaa gttgaaaaag     1560

atcaagagtt cgcgggacca ggcactagcc gagcggtgct tagctgctct gactgaatgc     1620

gctgccagtg gtgatgggaa tattctggcg ctggcagtcg atgctagtcg agcccgatgt     1680

accgtgggag aaatcacaga cgctctgaaa aaggtcttcg gagaacataa agctaatgac     1740

cgcatggtca gcggtgcata ccgacaagaa tttggggaaa gcaaggagat taccagcgct     1800

atcaagaggg tgcacaagtt tatggagagg gagggcagaa ggcctcgtct tctcgtcgcc     1860

aagatgggtc aggacgggca cgatcgcggt gctaaagtga tcgccacagg ctttgcggat     1920

ctcggctttg atgtcgatat tggtcccctc tttcaaaccc cacgcgaggt tgcacagcaa     1980

gctgtcgacg ctgatgtgca cgcggtgggc gtgtccacgc tagccgcagg acataaaaca     2040

ctggtaccag aactgattaa ggaactgaat agtctcggac gtccagacat tctcgtgatg     2100

tgtggtggag tgataccccc acaagattac gagttcttgt ttgaggtggg ggtgtctaat     2160

gttttcggtc ctggcacaag aatccccaaa gccgctgtgc aggtgctgga cgatatcgag     2220

aagtgcctag agaaaaagca acaaagcgtc                                      2250


<210>  63
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  63
atgcttcggg ctaaaaatca gctttttttg ctgagccccc attacttacg gcaggttaaa       60

gagagttctg gatctaggtt aatccaacag agattgctgc accaacaaca gcctctacac      120

ccagagtggg ccgccttggc gaagaagcag ctgaaaggaa agaatccgga agatctcatc      180

tggcacaccc ctgagggcat ctctataaaa cctctgtatt ccaagcgcga cactatggac      240

ctgccagagg agcttcctgg tgtgaagccc ttcacacgcg gcccgtatcc tactatgtat      300

acattccgtc catggaccat tagacagtat gctggctttt ctacagtgga ggaatctaat      360

aaattctaca aagataacat taaggccgga cagcagggcc taagtgtggc tttcgatctc      420

gccacccatc gcggatacga tagtgacaac cctagggtcc gtggagatgt gggcatggcc      480

ggcgtcgcaa tcgatactgt ggaagacaca aaaatacttt ttgacggaat cccacttgag      540

aaaatgtcag tttctatgac catgaacggg gccgtcattc ccgtactggc aaatttcatt      600

gttaccgggg aggagcaggg agtgccgaaa gagaagctta ccgggaccat tcaaaatgat      660

atcctgaagg agttcatggt taggaatact tatatcttcc cacctgagcc cagcatgaaa      720

attattgcgg acatctttga gtacaccgca aagcatatgc ctaagttcaa ttcgatctcc      780

attagcggat atcatatgca ggaggcaggc gcggacgcta ttttggaact ggcgtatacc      840

cttgccgacg gccttgaata ctctaggaca ggactgcagg ctgggctcac catcgacgag      900

ttcgcccccc gccttagctt tttttggggc attgggatga acttctatat ggagatagcc      960

aaaatgaggg cgggtcggag gctgtgggcc cacctaatag aaaaaatgtt ccagcccaag     1020

aatagtaaat cattgctgtt gagggcgcat tgccagactt ctggatggtc actgacagaa     1080

caggacccct acaataacat tgtgcgcacc gcaatcgaag cgatggccgc ggtgttcggt     1140

ggaacccaga gtctgcacac gaattctttc gacgaagcac tcgggctgcc caccgtgaag     1200

tcagctagga tcgcacgcaa cacacagata atcatccagg aggagagcgg gatccccaaa     1260

gtcgctgatc cctggggtgg gagctacatg atggagtgtc tgacaaacga tgtttatgat     1320

gcagcactga agctaattaa tgagatcgaa gagatgggtg gcatggccaa ggccgtggcc     1380

gaagggatac ccaaacttcg cattgaagaa tgcgctgcca ggcggcaggc gaggatcgac     1440

agcgggtccg aggtgattgt gggggtgaac aaatatcagc tcgagaaaga ggatgcggtg     1500

gaagttttgg cgatcgataa cacttctgta cgaaatcgtc agattgagaa attgaagaaa     1560

atcaagagct ctagggatca ggctctcgct gaaaggtgtc ttgccgcatt aacagagtgc     1620

gccgcgtcag gagatgggaa catcctcgcc ctcgccgtgg acgcttcacg cgctagatgt     1680

acggtgggag agatcaccga cgcactgaaa aaagttttcg gggaacataa ggctaacgac     1740

cgaatggtaa gcggtgccta tcgacaggaa ttcggcgaat ccaaggagat cacatcagcc     1800

atcaaaaggg tccataagtt tatggagagg gagggaagac gccctcgact gctggtcgcc     1860

aagatgggac aggatggcca cgaccgagga gcgaaggtga tagccaccgg cttcgccgat     1920

ctgggcttcg acgtggacat cggcccctta ttccaaactc ccagggaggt tgcccaacag     1980

gcagtggacg cggatgtaca tgcagttgga gtctctacgc tcgccgctgg gcacaagact     2040

cttgtgcccg aactcattaa ggagcttaat tccttgggtc gtccagatat cttagtaatg     2100

tgcggtgggg ttattcctcc tcaggactat gaatttctct ttgaagtggg cgtctcaaat     2160

gttttcgggc ctggcacacg aattccaaag gcagcagtgc aagtactcga cgacatcgag     2220

aagtgcttgg aaaagaaaca gcagagcgtt                                      2250


<210>  64
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  64
atgttgaggg ccaagaatca gctgtttctg ctgtcccccc actacctccg acaagtaaag       60

gagagttctg gaagcagatt gatccagcag cggctcctcc atcagcagca gcctcttcac      120

ccagagtggg cggccctcgc caagaagcag cttaagggaa agaacccaga ggatctcatc      180

tggcatacac ccgaagggat cagcatcaaa cccctgtact ccaaacggga cacaatggac      240

ctgcccgagg agctccctgg ggtgaaacca tttactaggg gcccttatcc cacaatgtat      300

acttttaggc cctggactat aaggcaatac gccggattct ccactgtaga ggagagcaac      360

aagttctata aggacaatat caaagccgga caacaggggc tcagtgtggc cttcgattta      420

gccactcacc gcggttacga ttccgacaat ccacgggtgc gtggcgacgt cggaatggcc      480

ggagtagcca tcgacacagt ggaggacaca aagatcctgt tcgatggtat ccctcttgaa      540

aagatgtctg tgagcatgac tatgaacggc gccgtgattc ccgtgctggc taacttcata      600

gtcaccgggg aagagcaggg agtccccaag gagaaactaa ccggaacaat acagaatgat      660

atacttaaag aattcatggt cagaaacacc tacattttcc ctccagagcc atcaatgaag      720

attatcgccg atatctttga gtatactgcc aagcacatgc ccaaattcaa ttccatatct      780

attagcggtt accatatgca ggaagcaggc gcggatgcga tcctggaact ggcttacacg      840

ctggccgacg ggctcgagta ttcacgcaca gggctgcagg cagggttaac catcgatgag      900

ttcgccccca ggctttcttt tttctgggga atcggaatga atttttatat ggagatcgcc      960

aagatgaggg cggggcggag gctttgggct catctgatcg aaaaaatgtt tcagcccaaa     1020

aattcaaagt ctctgttgct tagggctcac tgtcagacaa gcggctggag ccttaccgaa     1080

caggaccctt acaacaatat tgtgcggacc gctatagagg cgatggctgc cgtgttcggc     1140

ggaacccaga gcctgcacac caactccttc gatgaagccc tgggccttcc tacagtgaaa     1200

tccgcccgga tcgctagaaa cactcagatc atcatacagg aggagtctgg gattcccaag     1260

gtggccgatc cctggggagg tagctacatg atggagtgcc ttaccaatga tgtatacgat     1320

gccgccctga aactgattaa tgagattgaa gagatgggtg ggatggcaaa ggctgttgcc     1380

gaaggtattc ccaagctgcg cattgaggaa tgcgcagcaa ggcggcaggc aagaatcgac     1440

agtgggagcg aggttatagt gggggtgaac aaatatcagc tggagaaaga agatgctgta     1500

gaggtcctgg cgatagacaa cacaagcgtg cgcaaccgac agattgagaa acttaagaaa     1560

attaagagtt cccgggatca agccttagcc gagcggtgtc tcgcagcact gaccgaatgt     1620

gctgctagcg gggatggaaa cattctggct ttggcagtgg atgccagcag ggctcgttgc     1680

acagtcggcg aaatcaccga tgccctgaag aaagtgttcg gggaacataa ggctaacgat     1740

cggatggtgt ccggcgccta tcgccaggag ttcggggaga gcaaggagat tacaagcgcc     1800

attaaaaggg tgcataagtt catggagcgc gagggaaggc gacctaggct gctcgtcgca     1860

aagatgggcc aagacggtca tgacaggggc gctaaagtca ttgccaccgg cttcgctgat     1920

ctcggatttg acgtggatat cggccctctg ttccaaactc cacgggaggt tgcccaacaa     1980

gctgtggatg ccgatgtgca tgccgtaggc gtcagtacgc tcgctgccgg ccacaagact     2040

ctcgtgccgg agctgattaa ggaactgaat tccctcggca ggcctgacat tttggtcatg     2100

tgcggaggag tcatccctcc acaggattac gagtttctgt tcgaagtggg cgtgagcaac     2160

gtgtttggcc ccggaacgcg aatccccaag gccgccgtgc aggttctcga tgacatcgaa     2220

aaatgtttgg aaaaaaaaca gcaaagcgtt                                      2250


<210>  65
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  65
atgcttcggg ccaagaacca gttgtttttg ctaagtccac attatcttag acaggtcaag       60

gagagcagcg gatcccggct tatccagcag cggctgttac atcagcaaca gccgcttcat      120

ccagagtggg cggctcttgc caagaagcag ctgaagggta agaaccctga agacctaata      180

tggcacacac ctgagggcat ctcaatcaag ccactctata gcaagagaga tacaatggac      240

cttcctgagg agctaccggg tgtgaagccc tttactaggg ggccctaccc caccatgtac      300

acctttcgcc catggaccat tcgccagtac gctggcttct ccactgtcga ggaatcgaac      360

aaattttaca aagataatat taaagctggt cagcaaggcc tttcggtcgc tttcgatctg      420

gcaactcata ggggctacga ctcagacaac cctagagtgc ggggcgacgt aggaatggcg      480

ggagttgcca tcgatactgt ggaggacaca aaaatacttt ttgatgggat cccattggag      540

aaaatgtccg tgtcaatgac catgaatgga gctgtgatcc ccgtgctggc caacttcatt      600

gtgacgggtg aggaacaagg cgtcccaaaa gaaaagttga ctggaaccat ccagaatgac      660

attctgaagg aattcatggt acggaacacc tacatcttcc ctccagagcc atctatgaaa      720

atcatagctg atatctttga gtataccgcg aagcacatgc ccaagttcaa ctctatcagc      780

atatccgggt accacatgca ggaagccggc gccgacgcca tcctcgagct ggcctacact      840

ttggccgacg ggctggagta cagtcggact ggcctgcaag cgggattaac gatcgacgag      900

tttgccccgc gcctttcatt tttttggggg atcggtatga acttctatat ggagatcgct      960

aaaatgcgtg cagggcgaag actttgggcc caccttatcg agaagatgtt tcagcccaag     1020

aactcaaagt ccctcctttt aagggcacac tgtcagacat caggatggtc ccttactgag     1080

caggatcctt ataacaatat tgtgcgaacc gcaatcgagg ccatggcagc cgtgttcgga     1140

ggaactcaga gccttcacac aaattccttc gatgaagcac tgggccttcc gaccgtgaaa     1200

agtgccagaa ttgccaggaa cacccagatt ataattcaag aggagagcgg catcccaaag     1260

gttgccgatc cctggggtgg cagttacatg atggagtgtt tgactaacga cgtttatgat     1320

gctgccttaa aactgatcaa tgaaatcgag gaaatgggcg gtatggccaa agctgtggca     1380

gagggcatcc ccaagctacg gattgaagaa tgcgctgccc gaagacaggc aaggatcgac     1440

tcaggatcag aagttattgt gggcgtcaat aaataccagc tagagaagga ggatgcggta     1500

gaagtcctgg ccatcgataa tactagcgtg cggaaccgcc agattgagaa gctcaagaaa     1560

attaaatcta gtcgcgacca ggccctcgca gaaaggtgcc ttgcggctct caccgaatgt     1620

gcagcgtcag gcgacggtaa catcctggcg ctggccgttg atgccagtcg agctaggtgc     1680

actgtgggag aaattacaga cgctctcaag aaagttttcg gcgagcacaa ggcgaatgac     1740

cgcatggtgt cgggcgccta tcgccaggag ttcggagaga gcaaggagat tactagcgcc     1800

attaaacggg tacacaagtt catggaacgc gaggggagac gtccacggct gctggtagcc     1860

aaaatgggac aggacggaca cgaccgcgga gccaaagtga tcgcgacggg cttcgccgat     1920

cttggtttcg atgtggacat tggcccgctc ttccagacac caagagaggt tgcacagcag     1980

gcagtggatg cagacgtcca cgctgtgggc gtcagcacgc ttgccgctgg gcacaagacc     2040

ttggtccctg aactcatcaa agagttgaat agcctgggcc ggcccgacat cttggtgatg     2100

tgtggtgggg taataccccc ccaggattac gagttcctgt tcgaagtcgg agtatcgaat     2160

gttttcggtc ccggaacgag aattcctaag gctgctgtgc aagtgctgga tgatatagag     2220

aagtgtcttg agaagaagca gcagagcgtc                                      2250


<210>  66
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  66
atgctgcgtg ctaagaatca actgttcctg ctatctcccc actatctgag acaagtgaag       60

gagtcttccg gatctcggtt gattcagcaa cgcctgctgc accagcaaca gcctttgcat      120

cccgaatggg ccgcactggc gaaaaaacag ctgaagggca agaatccgga agacctcatt      180

tggcacactc cagaaggcat cagtatcaaa cctctttatt ctaaacgaga taccatggac      240

ctgcccgaag aactgcccgg agtaaagcct tttacccgcg ggccatatcc aactatgtac      300

acttttaggc cgtggactat cagacagtat gcgggcttta gcaccgtcga ggagtctaat      360

aagttctaca aggataacat taaagccggc cagcagggac tgagtgtggc ttttgaccta      420

gcgacacacc gcggctatga ctcagacaat ccccgagtgc gtggcgacgt tggcatggcg      480

ggagtagcca tcgacacagt ggaagataca aagatccttt tcgatggcat cccactggag      540

aagatgagtg taagtatgac gatgaacgga gcagtgatac cagtcctcgc caactttatc      600

gtgacgggtg aggagcaggg tgtgccaaaa gaaaagctga ccggaacgat ccagaacgat      660

atcctgaagg agttcatggt gcgaaacaca tatatcttcc ctcccgagcc tagtatgaaa      720

atcattgctg acatcttcga atataccgcc aaacacatgc ccaagttcaa ttctatctct      780

atcagtggct accatatgca ggaagccgga gctgacgcca tactcgaact ggcttataca      840

ctcgccgacg gtctcgaata ctccaggact ggcctacaag ccggactgac aatcgatgaa      900

tttgctccac ggttatcttt tttctggggg attggcatga acttttacat ggaaatagcc      960

aaaatgaggg ccggccggag gctttgggcc catctgatcg agaagatgtt ccagcccaag     1020

aatagtaaaa gccttcttct aagagcccac tgccagactt ctgggtggtc tctcactgag     1080

caggatccct acaataacat cgtcagaacc gctattgaag ccatggccgc cgtgtttggc     1140

ggcacccaaa gcttgcacac gaacagcttt gacgaagcac tcgggctacc gacagtgaag     1200

tccgcccgca ttgctcggaa cacccagatt attatccaag aagaaagcgg aattcctaag     1260

gttgccgatc cctggggcgg ctcatatatg atggaatgtc tgacgaatga cgtctacgat     1320

gcagcgctga agctgattaa cgagatcgaa gaaatgggag gcatggccaa ggctgtagct     1380

gagggcatac caaagctgcg cattgaggag tgcgccgccc ggcggcaggc ccgaatcgac     1440

tccggtagcg aagtcatcgt tggagttaat aagtatcagt tagaaaagga ggatgctgtg     1500

gaggtgctgg caatcgacaa taccagcgtg cggaatcgcc agattgaaaa actcaagaag     1560

atcaaatcct cccgagacca ggccttggcc gagcggtgct tggcggcctt aacagagtgc     1620

gcggccagtg gcgatgggaa cattctagca ctcgccgttg acgctagccg tgcaaggtgt     1680

acagtcggcg agatcacaga cgctttgaag aaggtgttcg gcgagcataa agcaaatgac     1740

cgcatggtgt ctggcgcata tcgccaagag ttcggagagt ctaaggaaat cacctccgcc     1800

atcaaaagag tgcataaatt catggagagg gaagggcgcc gcccacgtct gttagtggcc     1860

aaaatggggc aagacggtca tgaccgaggg gctaaagtga tagccacagg ctttgctgat     1920

ctgggatttg acgtggacat aggccccctg ttccagacgc caagggaagt cgcacagcag     1980

gctgtggatg cagacgtgca tgccgtgggg gtgtctacac tggctgccgg acataagact     2040

cttgtgccag aactgattaa ggagttaaat agtctgggac gcccagacat tctggtaatg     2100

tgtggagggg tgatccctcc tcaggactac gagtttctgt ttgaagtggg cgtgagcaac     2160

gtgttcggac ccggtacccg cattcccaag gcggcagtgc aggtgcttga tgatatcgaa     2220

aaatgccttg agaagaaaca gcagagtgtg                                      2250


<210>  67
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  67
atgttacggg ctaagaatca gctgttcctc ctctcgcccc attatctgcg ccaggtcaaa       60

gaaagctccg ggtctagatt gattcagcag agactcctgc atcagcagca gcctctgcac      120

cccgagtggg cagccctagc gaagaaacag ctaaagggca agaaccccga ggatctgata      180

tggcacactc ccgaagggat ctcgatcaag cccctctatt cgaagcggga cacaatggac      240

ctcccagagg agctccccgg agtaaagcct ttcactaggg gcccataccc aaccatgtac      300

actttccgcc cttggactat acggcagtac gccggctttt ccacagttga ggaaagcaac      360

aagttctaca aggataatat caaagccggc caacaagggt tgtccgtggc atttgacctg      420

gcgactcaca gggggtacga ctctgataat cctagggtgc ggggcgacgt tgggatggcc      480

ggggttgcga tcgataccgt ggaggacact aaaatattgt tcgacggcat cccattggag      540

aagatgagcg tgtcaatgac aatgaacgga gcagtgatac ctgttcttgc caacttcatt      600

gtgaccggtg aagagcaggg agtaccgaag gagaaactga caggcaccat ccagaatgac      660

atccttaaag agtttatggt cagaaacacc tatatattcc cacctgagcc tagtatgaaa      720

atcatagcag acatttttga atacacggcc aaacatatgc cgaagtttaa ctcaatcagc      780

atctctgggt accacatgca agaggcaggt gccgacgcta tcctggaact ggcatacacg      840

cttgcagatg gtttagaata ctccagaaca ggattgcagg ccggactcac aatcgacgaa      900

ttcgccccta gactctcctt cttctgggga attgggatga atttctacat ggaaattgcc      960

aaaatgcggg ccggccgacg cctttgggcg cacttgattg agaagatgtt ccagcctaag     1020

aactcgaagt cgttactgct cagagcgcac tgccagacat cggggtggtc tttaactgaa     1080

caggaccctt acaataatat tgtgcgcact gccattgagg ccatggcggc cgtattcggc     1140

gggacgcaat cgcttcacac caatagtttt gatgaagctc ttgggttacc taccgtgaag     1200

tccgcaagaa tcgcccgcaa tacccagatt attatccagg aggagagcgg cattccgaaa     1260

gtggccgatc catggggcgg cagctatatg atggaatgcc tcaccaatga cgtctatgat     1320

gctgctctca aacttataaa tgagatcgaa gagatgggtg gcatggctaa agccgtggcc     1380

gaaggcattc cgaaattgcg gatcgaggaa tgtgcagcga gacgccaggc tagaattgat     1440

agcggcagtg aagtaattgt cggggtgaac aagtaccagt tagaaaaaga ggatgccgtg     1500

gaggtgctgg ccatcgacaa cacttctgtt cggaacaggc aaatcgaaaa gctcaagaaa     1560

attaagtcaa gccgagatca agctctggcc gagagatgtt tggctgcctt gacagaatgt     1620

gctgcttcgg gggatggaaa catcttggct ctggctgtgg acgcaagccg ggcacgttgt     1680

actgttggag agatcaccga tgccctgaag aaagtgtttg gagaacataa ggcaaatgat     1740

aggatggtga gcggggcgta tcgtcaagaa tttggcgagt ccaaggagat cacttcagct     1800

attaaaagag tccacaaatt tatggaaagg gaagggagga gaccgaggct actggtggcc     1860

aaaatgggcc aggatggaca tgaccggggg gctaaggtta tcgccacagg attcgctgat     1920

ttgggattcg acgtggatat cggaccactt tttcagacac ctcgcgaggt agcgcaacag     1980

gcagtggatg cagatgttca cgctgttggt gtgtctacac tggctgccgg tcataaaacg     2040

ttggttcctg agttaataaa agaactgaac tcattgggac gacccgacat cctggtgatg     2100

tgtggcggtg tcatcccccc ccaggattac gagttcctgt ttgaggtcgg ggtgtccaat     2160

gtctttgggc ccgggaccag aattcccaaa gctgccgttc aggtgttgga cgatattgaa     2220

aagtgcttag aaaaaaagca gcagtcagtg                                      2250


<210>  68
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  68
atgcttagag ccaagaatca actgttctta ctctcaccac actatctcag acaggtgaag       60

gaatcaagcg gaagtagact gattcagcaa cgactattgc accagcaaca gccactgcac      120

cccgagtggg cagcactcgc caagaagcag ctgaagggga aaaaccctga agacctcatt      180

tggcatactc cagagggcat ctcaatcaaa ccactgtatt caaaacggga cacgatggac      240

ctacccgaag agttaccagg agtgaagccg ttcaccaggg gaccatatcc cacgatgtac      300

accttccggc catggacaat tcgccagtat gccggtttct ctaccgtcga agaatcaaat      360

aagttttata aggataacat caaggccggc cagcagggac tgtctgtggc ctttgatctt      420

gcaactcacc gcggctacga ttcagataat ccccgcgtgc ggggtgacgt tggtatggct      480

ggcgtggcga tcgatacagt tgaggacacc aagatcctgt tcgacggaat ccctctggaa      540

aaaatgagcg tctcaatgac gatgaatggt gccgtgatcc cagtgctggc caacttcatt      600

gtcacaggcg aggaacaggg tgttccgaaa gagaagctga caggcaccat ccagaatgat      660

atcctgaaag agtttatggt gagaaatact tatatcttcc ctccagaacc cagcatgaag      720

attattgccg atattttcga atacacagcc aaacacatgc caaaattcaa ttcgatctct      780

atctcaggtt atcacatgca ggaggcgggg gctgatgcca tcctggaact ggcatacact      840

ttagccgacg gattggagta ctccaggact ggcctgcaag caggactaac tattgatgag      900

tttgccccaa ggttgagctt tttttggggc attgggatga acttttacat ggagatcgca      960

aagatgagag ctggcagaag actatgggcc catctgatcg agaaaatgtt tcagccgaaa     1020

aactcaaaga gcttactgtt gcgagcgcat tgccagacat ccggctggtc attgacagaa     1080

caagacccct ataacaacat cgtgcggacg gccattgagg ccatggcggc cgtgtttgga     1140

gggacacaaa gcttgcacac caacagtttc gacgaggccc tgggcctccc cacagtgaaa     1200

tcagcgcgaa tagccaggaa tacccaaatc atcatccagg aagaatctgg tatcccgaag     1260

gtggcggacc cctggggcgg atcctacatg atggagtgtc ttaccaacga tgtgtacgat     1320

gcagccctga aactcatcaa tgaaatcgaa gagatgggag gcatggccaa ggccgtggcc     1380

gaagggatcc cgaaattgag gatcgaggag tgcgccgcta gacgccaggc gcgcatcgac     1440

tccgggtccg aagtcatagt tggcgtcaat aaataccagc tggaaaaaga agatgccgta     1500

gaggttttag caattgacaa taccagtgtg aggaaccgcc agattgagaa gttgaaaaag     1560

atcaaaagct cgcgagatca ggcccttgcc gagcgctgcc tagctgccct cactgagtgc     1620

gccgcttcag gcgacggcaa cattctggct ctcgctgtcg acgccagtcg agctagatgc     1680

accgtcggtg agatcactga cgccttgaag aaggtgttcg gggaacacaa ggcaaatgac     1740

cgcatggttt caggggctta cagacaggag tttggggagt ctaaagaaat taccagtgcc     1800

ataaaacgcg tccacaaatt catggaaaga gagggaagac ggcctcggct gttagtggcg     1860

aaaatgggcc aggacgggca tgaccggggc gccaaagtga ttgctaccgg ttttgcggac     1920

ctgggctttg atgttgacat aggacctctg ttccagactc cccgcgaggt cgcacagcag     1980

gccgtagacg ccgacgtaca cgcagtcggt gtgagcacat tggctgccgg ccacaagacc     2040

ctggttcccg agttgatcaa agagctgaac agtttgggtc gacctgatat cctcgttatg     2100

tgtggggggg tgataccccc ccaggactac gaatttttgt tcgaggttgg ggtcagcaat     2160

gtgttcgggc cgggcacaag gatccccaag gcagccgtac aggttctcga cgatatcgaa     2220

aaatgtctcg aaaagaaaca acagtctgtg                                      2250


<210>  69
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  69
atgctgagag ccaaaaacca actgtttctg ctctctcctc attatctgcg ccaggtcaaa       60

gagtcatctg gaagcaggtt aattcagcag aggctgctgc accagcagca gccccttcat      120

ccagagtggg ctgctctggc taagaaacag ctgaagggta agaatccgga agacttgatc      180

tggcacaccc cagagggcat aagcattaag cctctttata gtaagcgtga tacaatggac      240

ttacctgaag aactacccgg tgtgaagcca tttacaagag gcccgtatcc tacaatgtat      300

acatttcgcc cgtggaccat caggcagtac gcgggcttca gcaccgtaga agagtcaaac      360

aaattttata aggataatat taaagccgga cagcaagggt tgtccgtggc gtttgacttg      420

gcaacacacc gcggctacga ctcagacaac cctagggtca gaggcgacgt aggcatggcc      480

ggggtggcca tcgacacggt cgaggacaca aagatcctgt tcgatggcat tcccctggag      540

aagatgagtg tctctatgac aatgaacggg gccgtgattc ccgtgctcgc aaactttatc      600

gtgacagggg aggagcaggg agtacccaaa gagaagctca ccggtaccat acaaaacgat      660

attctgaagg agtttatggt aaggaacacg tatatctttc caccagaacc atccatgaag      720

attattgctg atatttttga atacactgca aaacacatgc ccaagttcaa tagcatctca      780

ataagtggct atcatatgca agaggctggc gcagacgcca ttctggaact cgcctatacc      840

ttggccgacg gtttggagta ctcccgcacc gggctccagg ctggcctgac cattgacgag      900

tttgcgccca ggcttagttt tttctggggt attggaatga atttttacat ggagatcgcc      960

aagatgaggg caggcaggag actctgggcg catctgatag agaagatgtt ccagcctaaa     1020

aattccaagt ccctgctgct gagagcccat tgccaaacca gcggttggtc tctgactgaa     1080

caggacccgt ataataatat cgtgagaaca gctatcgaag ctatggcagc cgtcttcgga     1140

ggaacacaat ctttgcacac gaatagcttc gacgaggcac tgggattgcc cactgtgaag     1200

agcgcccgga ttgcacgaaa cacccaaatc ataatccagg aggagtctgg catcccgaag     1260

gttgccgacc cttggggcgg gtcctacatg atggagtgcc tgacgaacga tgtgtatgat     1320

gctgccctca agttaataaa cgagatcgag gagatgggtg gcatggccaa agccgtggct     1380

gagggaattc ctaaactgcg gattgaagag tgcgcagcac ggagacaggc ccgaattgac     1440

tctggatctg aagtgatcgt cggagtcaat aagtaccagc tggagaaaga agatgctgtg     1500

gaagtcctgg ccatagacaa caccagcgtc cggaatagac agatcgagaa actgaaaaaa     1560

ataaagagta gcagagatca ggctcttgct gagcggtgtt tagccgctct gaccgagtgc     1620

gcagcgagcg gcgatggaaa tattctggct ctcgctgtag atgcttcaag agcaaggtgc     1680

actgtgggcg agatcactga cgcgttaaag aaggtcttcg gcgagcacaa agcgaatgac     1740

agaatggtgt ccggcgcata tcggcaagag tttggagagt ctaaggagat aacgagcgca     1800

ataaaacggg ttcacaaatt tatggaaaga gaaggccgcc gcccacgtct gctggtagca     1860

aagatgggcc aggatggcca tgaccgcggc gcaaaagtga ttgcaaccgg gttcgctgat     1920

cttggcttcg atgtggacat tgggccactg ttccagacac ctcgggaagt ggctcagcaa     1980

gcagttgatg cagacgttca cgcagtcggt gtgtccacgc tcgccgccgg acataagact     2040

ctcgtgcccg aactgatcaa agaactaaat tccttgggca ggccagacat cctggtgatg     2100

tgtggcggcg taattcctcc ccaggattac gagtttctct tcgaggtggg cgtgtccaat     2160

gtcttcggcc cagggacgcg tatccctaag gctgccgttc aggttctcga tgacatcgaa     2220

aagtgcctcg agaaaaagca gcagtcagtt                                      2250


<210>  70
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  70
atgctgcggg ctaagaatca actgtttctg ctgtcaccac attacttgag gcaggttaag       60

gaatctagcg gaagcaggtt aatacagcag aggttattgc accagcaaca acccttgcat      120

cccgagtggg ccgcgttagc caaaaagcag cttaagggca aaaatcccga ggacctgatc      180

tggcatacac cagagggcat tagtataaag ccactctatt ctaaaagaga tacaatggac      240

ctcccagagg agctgcctgg agtcaagccc tttactcggg gcccgtatcc caccatgtat      300

acattccggc cctggaccat ccggcaatat gccggattca gtactgtgga agaatcgaac      360

aaattctata aggataacat caaggccggg caacagggac tgagcgtggc attcgactta      420

gctacccaca gaggctacga cagcgataat ccaagagtcc ggggcgatgt gggtatggca      480

ggcgtggcca tcgacactgt cgaggacact aaaatcctct tcgatggaat acccctcgag      540

aagatgtcag tgtccatgac tatgaacggc gcggtgatcc cggtgctggc taactttatc      600

gtgacggggg aggagcaggg cgtgcctaag gagaaattga ccgggaccat ccaaaatgac      660

attctaaaag agttcatggt tagaaatacc tacattttcc cccctgagcc cagcatgaag      720

ataattgccg atatttttga gtatactgcc aaacacatgc caaaatttaa ctcaatcagc      780

atttcagggt atcatatgca ggaggccggc gctgatgcaa tcttagaact tgcttatact      840

ctggctgacg gcctggagta tagtcgaact ggactacagg ctggattaac tattgacgaa      900

tttgctccac gcctgagctt cttttggggc attggcatga acttctacat ggagattgcc      960

aaaatgagag caggacggcg actgtgggca caccttatag agaaaatgtt ccagcccaag     1020

aattccaaat cgctactgct tagagcgcac tgtcagacct ccggatggtc gctgaccgaa     1080

caggacccgt acaataatat tgtgaggact gccatcgagg ccatggcggc tgtctttggg     1140

gggacgcaat cgctacatac gaattctttc gacgaagctc tcggcctgcc aacagttaaa     1200

tcagctcgca tcgccagaaa cacccagatc atcattcagg aggaaagcgg gattcccaag     1260

gtggctgacc cttggggagg atcatatatg atggagtgtc tgaccaatga cgtatacgac     1320

gctgcactta agctcatcaa tgagattgag gagatgggcg gcatggctaa agctgtagcc     1380

gaagggattc caaaactgag gatcgaagag tgcgccgcaa ggcgacaagc acgtatagat     1440

tctggtagtg aggttatcgt gggcgtgaat aagtaccagc tggagaagga ggatgccgtt     1500

gaggttctgg ccattgacaa cacgtctgta cgcaatagac agattgagaa acttaagaaa     1560

atcaagagca gtagagatca ggctctggct gagcgctgtc tggcggcact cactgagtgt     1620

gcggcctccg gtgacggcaa tatactggca ctggcggtgg atgcgagcag ggcacggtgc     1680

accgttggag aaattacgga cgccctcaaa aaggtgttcg gcgaacataa ggcgaatgat     1740

cggatggtga gcggtgccta ccggcaggag ttcggcgaga gcaaggagat cacgtccgcc     1800

attaagagag tccataaatt catggaacga gagggccgcc ggccaagact gctggtggct     1860

aagatgggac aggacggaca cgaccgtggg gctaaggtca ttgccacagg gtttgccgat     1920

cttggcttcg atgtggatat cggcccttta ttccaaacac ctcgggaggt ggcccagcaa     1980

gcagtggatg ctgatgtaca tgccgtgggt gtgtctacgc ttgccgccgg ccataagacc     2040

ctggtccctg agttaattaa agaactgaat agtctgggca gacctgatat acttgtaatg     2100

tgcgggggag tgataccgcc tcaggactac gaatttctgt tcgaggtcgg cgtcagtaat     2160

gttttcgggc ctggcacacg cattccaaaa gccgccgtac aggtcttgga tgatattgaa     2220

aagtgcctgg agaagaagca gcagagcgta                                      2250


<210>  71
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  71
atgctgcgtg ccaagaacca attgtttctt ctgagccccc actatctcag acaggtgaaa       60

gagagctcgg ggtcacggct gatccagcag agactactgc accagcagca gcccctacac      120

cccgagtggg ctgctctggc caagaaacag ctgaagggca agaaccctga agacctgatc      180

tggcacaccc ctgaaggcat ttcaatcaaa cccttgtaca gcaagcgaga tactatggac      240

ctgccagagg agctccctgg cgttaagcct tttacacggg ggccctatcc caccatgtac      300

acattccgtc cctggaccat caggcaatat gcaggcttca gcacagttga ggagagcaat      360

aagttctaca aagacaacat caaagccggg cagcagggcc ttagcgtggc atttgatctg      420

gccacccata ggggttatga cagcgacaat ccccgtgttc gcggcgacgt gggtatggcc      480

ggcgtagcga ttgacacagt cgaggacact aagatcctat tcgacggaat cccgctggaa      540

aagatgtctg tgtctatgac catgaatggg gcagtgatcc ctgtgctcgc taacttcatc      600

gtcaccgggg aagaacaggg cgtgcccaaa gagaagctga ccggaacaat tcagaacgat      660

atcctcaaag agttcatggt gcgcaatacc tatatttttc cccctgaacc tagtatgaaa      720

attatagccg atatctttga atataccgca aaacatatgc ctaagtttaa ctccatctca      780

attagcgggt accacatgca agaagccggg gccgacgcta tcttggagct ggcatatacc      840

ttggccgacg gactggaata ttctcggacc gggcttcagg ccggtcttac cattgacgag      900

tttgcaccaa gactctcatt tttctggggc atagggatga acttctacat ggagatagct      960

aaaatgagag ccgggcgacg cctatgggcc caccttattg aaaaaatgtt tcagcctaag     1020

aattctaaat ccttgctgtt gcgggcccac tgccagacga gcgggtggag cctgacggag     1080

caggacccct ataacaacat cgtgaggaca gcaatagagg ccatggccgc agtgttcggg     1140

ggcacccaaa gcctgcacac aaactccttt gatgaggcac tcggtctccc cacagtcaaa     1200

agcgcgcgga tcgccagaaa tacccagata attattcagg aagagtcggg tattccaaaa     1260

gtggcagacc cgtggggagg gtcttatatg atggaatgcc tgactaacga tgtgtatgac     1320

gcagccttga agctgataaa tgaaatagag gagatgggtg gaatggcaaa agccgtcgca     1380

gagggtattc ccaagctccg gattgaagag tgtgccgcac gcaggcaggc tagaatagac     1440

tctgggtctg aggtcatcgt gggagtcaat aaataccagc tggaaaagga agatgccgtg     1500

gaagtgctag ctatcgacaa tacaagcgtt agaaatagac agatcgaaaa gctgaaaaag     1560

attaagtcca gccgtgacca ggcactggct gagcggtgcc tggccgcact gacagagtgc     1620

gccgccagcg gagatggcaa tattctggct ctggcagtgg atgcatccag ggcacggtgc     1680

accgtgggag aaatcaccga cgccctcaag aaggtgttcg gagagcataa ggccaacgac     1740

aggatggtga gtggtgcgta tagacaggaa ttcggggaga gtaaggagat cacctcagcc     1800

ataaagaggg tccacaagtt tatggagaga gaagggagac ggccccgact gctcgtcgcg     1860

aagatggggc aggacgggca cgatcggggg gcaaaggtta ttgccactgg ctttgcagac     1920

ttaggcttcg acgtggacat cggcccactt ttccagacac cccgggaagt cgcccagcaa     1980

gcggtggacg cagacgtgca cgctgtgggc gtcagcacac tggctgccgg tcacaaaacc     2040

ctggtaccgg agctaataaa agagctcaat tcgctgggac gccccgacat ccttgtgatg     2100

tgtggtggtg ttattcctcc gcaggactac gaatttttgt tcgaagtcgg cgtgagcaac     2160

gttttcgggc caggtaccag aatccccaaa gctgcagtac aggtactgga tgatattgag     2220

aagtgcctgg agaagaaaca gcagagcgtg                                      2250


<210>  72
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  72
atgctgcgag ccaaaaacca actcttcctg ctgagccctc actatcttcg gcaagttaag       60

gagagctctg gctcccgact gatccagcag agactgctcc accagcaaca accacttcat      120

ccggaatggg ccgcgctggc caagaagcag ctaaagggga agaaccccga ggacctgatc      180

tggcacactc cggaagggat tagtatcaaa cccttatata gtaagaggga tacaatggat      240

cttccggagg agttaccagg agtgaaacct tttacccgcg gcccctatcc cactatgtac      300

actttcaggc cttggacgat taggcaatat gctggatttt ccacagtgga agaatctaac      360

aagttctata aagataatat taaagcgggg cagcagggcc tgtcagtggc tttcgattta      420

gcgacacacc gcggctacga ttcagacaac ccgagagttc gaggggatgt tggaatggcc      480

ggagtggcca tagacactgt cgaggacact aagattctgt ttgatgggat ccctcttgag      540

aaaatgtctg tgagtatgac aatgaatgga gctgtgatcc ctgtgctggc gaacttcatc      600

gtcactggcg aagaacaggg tgtacctaaa gagaagctga cgggcactat ccagaacgat      660

atactgaagg agtttatggt gcgcaacact tacatcttcc caccagagcc ctctatgaag      720

atcatcgccg atatctttga gtatacagct aagcatatgc ctaaattcaa cagtatcagt      780

atatctggat atcacatgca ggaagccggt gccgacgcga ttcttgagct ggcctacacc      840

ctggccgacg ggctcgagta cagcagaacg ggtctgcaag caggactgac tatagacgaa      900

ttcgcccccc gattatcatt cttctggggt attgggatga atttttacat ggaaatagct      960

aagatgagag ctggtcggag gctgtgggcg cacttgatcg agaagatgtt tcagccaaaa     1020

aattctaagt ctctcttgtt gcgcgcgcac tgtcagactt caggatggag cctgaccgag     1080

caggatcctt acaataatat cgttcgcaca gcaatcgagg cgatggctgc tgtgttcggg     1140

ggcacccaat ccttgcacac caattccttc gatgaagctc ttgggctgcc aaccgtcaaa     1200

agcgctcgga ttgctaggaa cacacagatt atcatacaag aagagtcggg catccctaaa     1260

gttgccgatc cgtggggtgg gtcttacatg atggagtgtc tgaccaatga cgtctacgat     1320

gccgcactga aactgatcaa cgaaatcgag gaaatggggg ggatggcaaa agcggtagct     1380

gagggcatcc ccaaattgcg tatcgaggag tgcgccgcaa ggagacaggc cagaattgat     1440

tcaggaagcg aagtaatagt aggcgtcaat aagtaccaat tggaaaagga ggacgcggtc     1500

gaagtgctgg ctattgacaa cacctccgtg aggaatcgcc aaatagagaa actcaaaaag     1560

atcaaatctt ccagggatca ggccctggcc gagcgctgtc tcgccgcttt gaccgaatgc     1620

gccgcttccg gcgacggtaa catcttagcg cttgccgtgg acgcatctcg cgctcgatgc     1680

acggtgggcg aaataaccga tgcattgaag aaggtctttg gcgagcacaa ggcaaacgat     1740

cggatggtgt ctggtgccta tcgtcaggag tttggcgaat ccaaggaaat tacctctgct     1800

ataaagcgag tacacaagtt tatggagcgg gagggccgcc ggccccgact gctggttgcg     1860

aagatgggac aagatgggca tgatcgcggc gctaaagtga ttgcaactgg cttcgcagac     1920

ctgggcttcg atgttgatat aggtccactc ttccagacac cacgcgaagt tgctcagcag     1980

gcagtggacg ctgatgtcca tgccgtgggg gttagtacat tagctgctgg gcataagacc     2040

cttgtcccgg aattaattaa ggaactgaac agcctgggga ggcctgacat cctggtcatg     2100

tgcggcgggg tgatcccccc ccaggactac gagtttctgt tcgaagtggg agttagtaat     2160

gttttcggac ccgggacccg cattcctaaa gcagcagtcc aggttctgga tgatattgag     2220

aagtgtctgg agaaaaaaca gcagtccgtc                                      2250


<210>  73
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  73
atgctgagag caaaaaacca gctcttcctg ctgtcgcccc attatctgcg acaggtcaag       60

gagtcgagcg gcagtaggct catccaacag cgcctgctgc atcaacagca accccttcac      120

cctgagtggg cagccctggc caagaagcag ctcaaaggca agaaccctga ggatctgatt      180

tggcatacac ctgagggtat ttctattaaa ccactgtact caaaaagaga cacaatggat      240

ctccccgaag agcttcccgg agtgaagcct tttactaggg gaccttaccc aacgatgtat      300

acgttcagac cctggacaat tcgtcaatat gcaggattct ccacggtgga agaatcgaac      360

aaattttaca aagataacat caaagcggga cagcaggggc tcagcgtggc gttcgatcta      420

gcgacccatc gcggatacga ctcggacaac cccagggttc ggggggacgt gggcatggcc      480

ggcgtggcca tagatacagt cgaggacacc aaaattctgt ttgacggcat ccccctggaa      540

aaaatgagtg tttcaatgac gatgaacggg gccgtcatcc ccgtactggc aaacttcata      600

gtgacagggg aagagcaggg cgtgccaaag gagaagctca cagggaccat ccaaaatgac      660

attctaaaag agttcatggt tcgaaacacc tacatcttcc cccccgagcc ttctatgaag      720

attatagctg atatctttga gtacactgcg aagcacatgc caaaattcaa ctctatctct      780

atcagtggat accatatgca ggaggcaggt gctgatgcca tcttagaatt agcctacacc      840

ttggctgacg ggctcgagta cagccgaacc ggcctgcagg ctggactcac aattgatgaa      900

ttcgctccta gactcagctt cttctgggga attggcatga atttctatat ggagatcgcg      960

aagatgcgag ctggccgcag gctctgggcc catctcatag aaaagatgtt tcaacctaaa     1020

aatagcaagt cactgttatt gcgcgcccac tgtcagacgt ccggctggag cctgacggag     1080

caggacccat acaacaatat tgtcagaaca gcaatcgaag ctatggcagc tgtgttcggt     1140

gggacacaat ctctgcatac taatagtttt gacgaggcgc tcgggttgcc cacggtcaaa     1200

tctgccagaa tagcgcgcaa cacccagatc attatccagg aagagagcgg tattcctaaa     1260

gtagccgacc cttggggggg cagctacatg atggagtgtc tgaccaacga cgtttacgat     1320

gctgctctga aattgatcaa tgaaatcgaa gagatgggcg gaatggctaa ggctgtcgct     1380

gaagggattc ctaaattgag aattgaggag tgtgcagcca ggcgtcaggc ccggatcgac     1440

tctgggtctg aggtcattgt gggcgtcaat aaatatcagt tggagaagga ggacgccgta     1500

gaagttctgg caatcgataa caccagtgtt agaaacaggc agatcgaaaa attgaaaaag     1560

attaagtcat cacgagatca ggccttggca gaacgttgcc ttgctgcttt aaccgaatgt     1620

gccgcctcgg gggatgggaa tatcctggcc ctcgcggtag acgcatccag agcacgctgc     1680

accgttggtg aaatcacaga tgcgctgaag aaagtgtttg gcgaacataa ggcgaacgac     1740

agaatggtga gcggagccta ccgccaagag ttcggcgaat ccaaagagat tactagcgcg     1800

atcaagcgag ttcacaagtt tatggaacgg gagggcagaa ggccaagact gctggtcgct     1860

aaaatgggcc aggatgggca tgaccgtggc gctaaggtga tagctaccgg ctttgcagac     1920

cttggattcg atgtggacat aggtcctctg tttcagactc ccagagaggt ggctcaacag     1980

gcagttgatg ctgacgttca cgccgtgggc gtatcaacct tagccgccgg gcacaaaaca     2040

ctcgtccccg aattgatcaa ggaattgaat tccctaggca gaccggacat cttggtgatg     2100

tgtggcggcg tgattccccc acaggactat gaattcctct tcgaagttgg agtttccaac     2160

gtgttcggac caggaacccg tattcctaag gcagctgtac aggtcctgga tgacattgag     2220

aaatgcctgg aaaagaaaca gcaaagcgtc                                      2250


<210>  74
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  74
atgttgcggg cgaagaacca gctcttctta ttgtccccgc actacctccg acaagtaaaa       60

gaatcctctg gctcaaggct gattcaacag cgattgctcc accagcagca acctttacat      120

cccgaatggg ctgctctggc caagaagcag ctgaagggaa aaaaccctga agacctgatc      180

tggcatacac cggaggggat ttccattaag ccgctctatt cgaaacgaga cacgatggat      240

ctgcctgagg agctgcctgg ggtcaaacca tttaccaggg ggccgtaccc cacgatgtat      300

actttccggc cctggaccat aagacaatac gccggcttct ccaccgtgga agagtccaac      360

aaattttata aggataacat taaggcggga caacagggtc tgtccgtggc atttgacctc      420

gccacacatc gcggctacga ttctgacaat ccacgcgttc gcggggacgt gggcatggca      480

ggcgtcgcaa tcgacaccgt ggaagatacc aaaatcttgt ttgacggcat tccgttggag      540

aagatgtctg tcagcatgac catgaacgga gcggtgattc ccgtcctcgc caacttcatc      600

gttacaggcg aggaacaggg tgtccccaag gaaaaactga ctggcaccat ccagaatgac      660

attctaaagg aatttatggt ccgcaatacc tacatcttcc cacctgaacc gtccatgaag      720

atcatcgccg atattttcga gtataccgcc aaacatatgc ctaaattcaa cagcataagt      780

atttcaggat accatatgca agaggctggt gccgacgcga ttctggaact tgcttacact      840

ctggcggacg gcttggagta ttctcgcacc ggtctccagg cgggcctgac aattgatgag      900

tttgccccaa ggctgtcgtt tttctggggt atcggtatga acttctatat ggagatcgcg      960

aagatgaggg ccgggcggcg cctatgggca cacctgatcg aaaaaatgtt tcagcccaag     1020

aatagcaaat cactgctgct acgggcccat tgtcagacgt ctggatggtc cctcaccgaa     1080

caggacccct acaataacat agtgcgtacc gccattgaag cgatggctgc cgttttcgga     1140

ggcacccagt cccttcacac aaactccttc gatgaagccc tgggcctccc tacagtcaag     1200

tctgcccgca ttgcacgcaa tactcagatc attattcagg aagagtcagg aatccccaag     1260

gttgcagacc catggggtgg cagttatatg atggagtgtc ttacaaatga cgtctacgat     1320

gctgctctga agctaatcaa tgagattgag gagatgggag ggatggccaa ggcagtcgcc     1380

gaggggattc ccaaactcag aatcgaagag tgcgcagcaa ggagacaggc ccggattgat     1440

tccgggtccg aagtgatcgt tggtgtgaat aagtatcaac tcgaaaaaga ggatgctgtg     1500

gaggtcctgg ccatcgacaa cacctccgtc aggaatagac agatcgaaaa attgaagaag     1560

atcaagtcat ctcgcgacca agccctggca gagagatgct tagcagccct aaccgagtgt     1620

gcagcctctg gggacgggaa catcttggct cttgctgtgg atgctagcag ggcacgatgc     1680

accgtggggg agatcacaga tgccttgaag aaagtgttcg gcgagcacaa agccaatgac     1740

cgaatggtaa gcggggctta tagacaagaa tttggggaat ctaaagagat aacctcggcc     1800

atcaagcgcg tccataagtt catggagcgg gagggacgca ggccccggct gctcgtagcc     1860

aaaatgggtc aggacgggca cgatagggga gctaaggtga tcgcgaccgg ctttgctgat     1920

cttggcttcg acgtcgacat cggaccactg tttcagactc ctagagaagt tgctcaacag     1980

gccgtagacg ccgatgttca cgccgtgggg gtgagcacac tggctgccgg gcataaaaca     2040

ctcgtgccgg agctcatcaa agaacttaac tcgcttggaa gacccgatat cctagtgatg     2100

tgcgggggtg taattccccc gcaggactac gagtttcttt tcgaggttgg agttagcaat     2160

gtgtttggac ccggtacccg gatccctaaa gctgcggtgc aggttctgga cgacattgag     2220

aagtgtctcg agaagaaaca gcaaagcgta                                      2250


<210>  75
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  75
atgctgcgcg ccaagaacca gttgttcctg ctttctccac actacctgag acaggtcaag       60

gagagcagcg gatctagact catccaacag agactgcttc accagcagca gccgcttcat      120

cctgagtggg ccgcccttgc caagaagcaa ttaaaaggaa agaaccccga ggatcttatc      180

tggcatacgc ctgaaggtat ttcaatcaag cctctctata gcaaaagaga cacaatggat      240

ctccccgagg agctgccagg ggtgaaacct tttacgagag ggccctatcc aacaatgtat      300

acattcaggc catggaccat tcggcagtat gcaggctttt ccactgtgga agagagcaat      360

aaattttaca aagacaacat taaggcgggc cagcagggtt taagtgtggc cttcgattta      420

gccactcatc gcgggtacga ttcagacaat cccagagtgc ggggggacgt aggcatggcg      480

ggtgtcgcaa ttgacaccgt agaggacaca aaaattcttt tcgacgggat tccccttgag      540

aaaatgagtg ttagcatgac tatgaacggg gctgtcattc cagtgctggc gaattttatt      600

gtgaccggcg aggagcaggg ggtacccaag gagaaactga caggtaccat acagaacgac      660

attttgaaag agttcatggt gcgcaacaca tatatattcc ctcctgaacc atctatgaag      720

attatcgcgg acattttcga gtacaccgca aagcatatgc ccaagttcaa ctcaatctct      780

atttctggct atcacatgca ggaagcaggg gctgatgcga tactggagct ggcctacaca      840

ctggccgacg ggcttgaata ctcccggacc gggttgcaag caggactaac gattgatgaa      900

tttgcgccga gactatcttt cttttgggga attggtatga atttctacat ggagatcgcc      960

aagatgcgcg cgggcagacg cctctgggcc cacctgatag agaaaatgtt ccaaccaaag     1020

aatagtaagt ccctgctgtt gagggcccac tgtcagacct ccggatggag tctgaccgag     1080

caggacccat ataacaacat tgtgagaacc gcaatagaag ccatggccgc agtcttcggt     1140

ggcacacaat ccctgcatac caactctttt gacgaagctt taggtctacc aaccgtcaag     1200

tctgctcgca tcgccaggaa cactcaaata atcatccagg aagagtcggg aattcctaaa     1260

gtggccgacc cgtggggtgg gtcatacatg atggaatgcc tcaccaatga tgtgtatgac     1320

gctgctctta aactgataaa cgagatcgag gaaatgggcg gaatggctaa agccgtggcg     1380

gaaggtatac cgaaactcag gatcgaagaa tgtgcagctc ggcggcaggc taggatcgac     1440

tctggctcag aggtgatcgt tggagtgaac aagtatcagc tagagaagga agatgctgtc     1500

gaagtgctcg caattgacaa cacaagcgta cgtaatagac agatcgaaaa actcaaaaaa     1560

atcaaaagct ctcgagacca ggctctcgcc gaaagatgcc tcgctgcact caccgaatgc     1620

gctgcctcag gagatggtaa tatactggcg cttgctgtgg acgcatctcg cgctaggtgc     1680

actgtggggg aaattacaga tgccctgaag aaagtgttcg gcgagcataa ggcgaatgac     1740

agaatggtaa gtggcgcgta tcggcaggaa tttggagaat ctaaggagat tacatcagca     1800

attaaacgcg tccataagtt catggaaagg gagggaaggc gcccaagact cctggtggca     1860

aaaatgggcc aagacgggca cgatcgaggc gctaaagtga ttgccaccgg gtttgctgat     1920

cttggctttg atgttgacat aggccctctg tttcaaaccc cgcgcgaggt tgctcagcag     1980

gctgtcgacg cagacgttca cgctgtcggc gtatccactc tcgctgccgg tcacaaaact     2040

ctggtccccg agttgataaa ggaactgaac tccctcggaa gaccagacat actggtgatg     2100

tgtgggggcg tcattccacc acaggattat gagtttctgt ttgaagtggg tgtgtctaac     2160

gttttcggac ccggaaccag gataccgaag gccgccgttc aagtattgga cgacattgag     2220

aaatgtctgg aaaaaaagca acaaagcgtt                                      2250


<210>  76
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  76
atgctgaggg caaaaaatca actgttcctg ttgagccccc actatttgcg tcaagtgaaa       60

gaaagctccg gctcccgctt aatccaacag cggttgcttc atcaacagca acccttgcac      120

cccgaatggg ccgcccttgc taagaaacag ctgaagggga aaaacccaga agacctgatt      180

tggcacaccc ccgaagggat tagtattaaa cctctttaca gcaagaggga cacaatggat      240

ttacctgaag agcttcctgg ggtcaagcct tttaccaggg gaccatatcc aacaatgtac      300

acttttaggc catggacaat tcgacaatat gctgggttca gcactgtgga ggagtctaat      360

aagttctaca aagataacat taaagcagga cagcaaggac tcagtgtcgc attcgattta      420

gctacccatc gaggctacga ctccgacaat ccaagagttc gcggcgacgt aggcatggcc      480

ggtgtcgcga tcgacactgt agaagatacc aagatactgt tcgacgggat tccattggaa      540

aaaatgtcag tcagcatgac aatgaacggc gccgtgattc ccgtgcttgc aaactttatt      600

gttacgggtg aggaacaggg agttcccaaa gagaaactga cgggcacaat tcagaatgat      660

atcttgaaag agttcatggt aagaaataca tatatctttc caccagaacc ctctatgaaa      720

attatagcgg acatttttga gtacaccgct aagcatatgc ctaagtttaa ttctatctcc      780

atcagcgggt accacatgca ggaggccgga gccgacgcca tcctcgaatt ggcctacacg      840

ctggcagacg gattggaata ttcccgaacc ggactccaag ctggcctcac aatagatgag      900

ttcgctcccc gcctttcatt tttttggggt atcggaatga atttttacat ggagatcgcc      960

aaaatgaggg ccggtagacg gctgtgggct catctgatcg aaaagatgtt ccagcctaag     1020

aatagcaagt ctctcctttt acgggcacac tgtcagacga gtggatggag tttgacagag     1080

caggatccct acaacaacat cgtgcgaacc gccattgagg ccatggccgc cgtgttcggg     1140

ggaacccaga gcttgcatac caactccttt gacgaagctc tgggcctgcc cacagtgaag     1200

agcgcccgca tagcacgcaa cacacagatt ataatccagg aagagtcagg cattcctaag     1260

gtcgcagatc cctggggtgg ttcttatatg atggaatgtc tgacaaacga cgtctacgac     1320

gctgccctaa agttgatcaa cgagatcgag gagatggggg gcatggcaaa ggcagtcgcc     1380

gaggggatcc ctaagctgag aatcgaagag tgcgccgcac ggaggcaggc ccgaattgac     1440

tcagggtctg aagtgattgt gggcgtaaac aaataccaat tggagaagga agacgctgta     1500

gaagtgcttg ctatcgataa taccagcgtg cgcaaccggc agatcgaaaa gctgaaaaaa     1560

attaaatctt cgcgtgacca ggctctggca gagcgatgtc tcgctgcgct tacagaatgc     1620

gccgccagcg gagatggaaa tatcctggca ctggccgtcg acgccagtag ggcccggtgc     1680

acggtgggag aaatcacaga cgctctgaag aaggtttttg gagagcacaa ggcgaatgat     1740

agaatggtct caggcgctta ccgtcaagag ttcggtgagt ccaaggagat cacctccgcc     1800

attaaacgag tccacaagtt catggaacga gaaggccgtc gtccccgact gctggtcgcc     1860

aagatggggc aggacggaca cgaccgcggt gccaaggtta tcgccacagg cttcgccgac     1920

ctggggtttg atgtggatat cggacccctg ttccagactc cgagggaagt tgctcaacaa     1980

gcagtggatg ctgacgttca tgccgttggt gtgtcgactc tcgcagcggg gcacaaaacg     2040

ttggtgcccg aactgataaa ggagctgaat tcgttgggac ggccggacat tttggtaatg     2100

tgcggcggcg tgattccccc tcaggattac gagtttctct tcgaggtggg tgtcagtaac     2160

gtgtttgggc cgggaactag aattcccaaa gcagctgtgc aggtgctgga tgatatcgag     2220

aaatgccttg aaaaaaagca gcagagcgtg                                      2250


<210>  77
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  77
atgcttaggg caaagaacca gctgttcctt ctgtcccccc actatcttag acaggtaaag       60

gagagctcgg ggtcacggct gatccagcag aggctcctgc accaacagca gcctctgcac      120

ccagaatggg ccgccctggc caaaaagcaa ctgaagggca aaaatccgga agacctgatt      180

tggcacaccc ccgagggtat tagcataaaa cccttgtaca gcaaaagaga taccatggac      240

ttaccagaag agttaccggg cgtgaaaccg ttcacccggg gaccctatcc cacaatgtac      300

accttccgtc catggacaat ccgccagtat gccggattca gcaccgtaga ggagagcaac      360

aagttttata aagacaatat caaggccggc caacagggac tctctgttgc gttcgacctt      420

gccacccacc ggggctacga ctcggacaac cctagggtcc gaggtgatgt tggcatggct      480

ggtgtggcca tcgacacggt tgaagatacc aagatcctgt tcgatggaat acctctcgag      540

aagatgtctg tttcaatgac gatgaacggc gcggttatcc cggtgttggc caatttcatt      600

gtgaccggtg aggaacaagg ggtccccaag gaaaagttaa caggcacaat ccaaaatgat      660

atcctcaaag aattcatggt gcgcaatacc tacatctttc cgccagaacc ttcaatgaaa      720

attatcgcag acatctttga atacaccgcc aagcacatgc ctaagttcaa ttctatatca      780

attagtgggt atcacatgca ggaagccggt gcagacgcta tattagagct tgcctacacc      840

ctcgccgatg gcctggagta ttctcgcacg ggtttgcagg ccggcctgac aattgacgag      900

tttgccccta gactaagctt tttctgggga atcgggatga atttctacat ggagatagcg      960

aaaatgcggg ctggaagacg gctctgggcc cacctcatcg aaaagatgtt ccagccaaaa     1020

aattcgaagt ctcttttact gagagcacat tgtcagacta gtgggtggag tctgaccgag     1080

caggatccgt acaacaacat cgtgagaact gccattgaag ctatggccgc agtgtttggg     1140

ggtacccagt cccttcacac caattccttt gacgaggctc tcggcctgcc aactgtgaag     1200

tctgccagga tcgctcgaaa tactcaaatt atcattcagg aggagagcgg aattcccaag     1260

gtggccgatc catggggagg ttcgtacatg atggaatgtc tgactaacga cgtctacgat     1320

gccgccctca agctgattaa cgagatagaa gaaatgggag gtatggcaaa ggcagttgct     1380

gaaggcatac ctaagcttag gattgaagag tgcgcagcaa gacggcaggc tagaatagat     1440

agcggaagtg aagtgatcgt tggggtgaac aaataccagc tcgaaaaaga agatgccgtt     1500

gaagtgctgg caattgacaa taccagtgtc cgaaataggc aaattgagaa acttaaaaag     1560

atcaagtcct ctcgggatca ggccctggcc gagcgatgtc tggcggctct cacagagtgt     1620

gccgcatccg gagacgggaa catccttgct ctggctgttg atgccagcag ggccagatgt     1680

actgtagggg agatcactga cgcccttaag aaggtcttcg gggaacataa ggctaatgac     1740

aggatggtct caggagccta tcgacaagag tttggagagt ctaaggagat aaccagtgct     1800

atcaagagag ttcacaaatt tatggagagg gaaggtcgcc gccctaggct tctggtggcc     1860

aaaatgggac aggatgggca cgatcggggc gctaaggtga ttgctaccgg gtttgccgat     1920

ctgggttttg atgtcgatat cgggcccctc ttccaaacac caagggaggt tgcccagcaa     1980

gccgttgacg ccgatgtgca tgccgtagga gtttcaactc tggctgcagg acacaaaacc     2040

ctcgtccccg agctcatcaa ggagttgaat tctttaggcc ggcctgacat tctcgtgatg     2100

tgtgggggag tgattccgcc tcaggactac gagttcctgt ttgaagtggg tgtctccaat     2160

gtctttggac ccggaacccg gatacctaag gccgcagtgc aagtgctaga cgacatagaa     2220

aagtgtttag aaaagaagca gcagtctgtc                                      2250


<210>  78
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  78
atgctaagag caaaaaatca gctcttccta ctgtccccac actacctgag gcaggttaag       60

gagtcttcag gctctagact cattcaacag cgcctcctcc atcaacaaca gccccttcat      120

cctgagtggg ccgcattggc gaaaaagcag ctcaaaggaa aaaatccaga ggacctgatc      180

tggcacacac cagagggcat ttcgattaag cccctatatt ctaaacgtga taccatggat      240

ctgccagaag agctccctgg agttaagcca tttacacggg ggccctaccc aacgatgtat      300

actttccggc cctggacaat cagacaatac gctggtttct caactgtgga agagagcaat      360

aaattttaca aagacaacat caaagctggg cagcaggggc tgtccgtggc ctttgatctg      420

gctacgcacc gaggatacga tagtgacaac ccccgggtgc ggggagatgt cggcatggcc      480

ggggttgcta tcgacaccgt ggaggataca aaaattctgt tcgatggcat cccgctggag      540

aagatgagtg tctctatgac catgaacgga gccgttatcc ctgtgctcgc caatttcatc      600

gtcaccggag aagaacaggg cgttcccaaa gagaagctga ccggaactat ccaaaatgat      660

atcctgaaag aattcatggt ccggaataca tatatctttc ctcctgagcc atccatgaag      720

atcattgccg acatcttcga gtacacagca aaacatatgc caaagtttaa ttcgattagc      780

atctcggggt accatatgca ggaagcaggt gccgatgcta ttcttgaact tgcctatacc      840

cttgcagatg gcctggaata ctctcgtacc ggcctccaag ctggcctgac tatagacgag      900

ttcgcaccca gactctcttt tttctgggga ataggaatga acttttatat ggagatcgcc      960

aaaatgcgtg cgggacgccg cctctgggca catctgatcg agaaaatgtt ccaacccaaa     1020

aactccaaat ctttgctgct gagagctcac tgccaaacct ccggctggag tctgactgaa     1080

caagacccct acaataacat tgttcgtacc gctatcgagg caatggcagc agtgtttggg     1140

ggtacccaat cgctgcatac gaacagcttc gatgaagctt tgggccttcc aacagtaaag     1200

agtgcgcgta tagcgcgaaa cacccaaatt attatccagg aggagtccgg cattccaaaa     1260

gtcgctgatc cctggggggg cagctatatg atggaatgcc tgactaatga cgtttacgat     1320

gctgcgctga aattgattaa cgaaatcgaa gaaatgggag gaatggcaaa ggcagtcgct     1380

gagggcatcc caaagcttag aattgaagaa tgtgcagctc ggcgccaggc taggattgac     1440

agcggtagtg aagtcattgt tggagtgaac aaatatcagc tcgaaaagga ggatgcagtg     1500

gaggtgctgg caatcgacaa cacttcagtg aggaaccggc agatcgagaa actaaaaaag     1560

ataaagagca gccgcgacca ggcattggcc gaacgctgtc tggccgcgct gaccgagtgt     1620

gctgccagtg gtgatgggaa cattttagca ctggccgttg acgcttcaag ggctcgatgc     1680

actgtgggcg agattacaga tgcactaaaa aaagtcttcg gcgaacacaa agcgaatgat     1740

cgtatggtca gcggggccta caggcaggag tttggagaaa gcaaggaaat tacatctgcc     1800

atcaagaggg tgcataaatt catggagagg gaagggagga ggcctagact gctggtcgcc     1860

aagatgggcc aagatggtca tgatcggggg gcaaaagtga tcgccaccgg ctttgctgac     1920

ttgggcttcg atgtggacat tggacccctg tttcagacac cgcgcgaggt tgcgcagcaa     1980

gccgtggacg cagatgtgca cgctgtcggg gtgagtacac tggctgccgg ccacaagacc     2040

ctggtgccag agttaattaa ggaactcaat agcctcggac gtccagacat tctcgtcatg     2100

tgcggtgggg taattccccc acaggactat gagtttcttt tcgaggttgg cgtatcaaat     2160

gtttttgggc ctggtacacg aatacccaaa gcggcagtcc aggtgctgga tgatatcgag     2220

aagtgccttg agaaaaaaca gcagtctgtc                                      2250


<210>  79
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  79
atgcttaggg cgaaaaacca gttgttcctc ctatcacccc actatctcag gcaggttaag       60

gagagctctg gctcacgcct catccaacag agactgttgc atcagcagca accactgcat      120

cctgagtggg ccgccctcgc taagaagcag cttaaaggaa agaatcctga ggacctgatt      180

tggcacaccc ctgaaggcat cagcatcaaa ccgctgtatt ctaagagaga caccatggac      240

cttcctgagg aactgcccgg cgtgaaaccc tttacacgcg ggccctaccc cactatgtac      300

acattccgac cctggactat cagacagtac gcaggcttca gcaccgtgga ggaaagcaat      360

aaattctaca aggacaatat caaggcgggt cagcagggcc tgtcagtggc atttgacctg      420

gcgacacaca ggggatacga ttcggataac ccccgggtta gaggtgacgt tgggatggcg      480

ggggtggcca tcgacacagt cgaagataca aaaatcctgt ttgacggtat accattagaa      540

aaaatgagcg tgagtatgac tatgaacgga gctgtaatcc ccgtgctcgc aaacttcatc      600

gtaacaggag aagaacaggg agttccgaag gagaagctga caggcaccat ccaaaatgac      660

atccttaagg agtttatggt gcggaacacg tacatattcc cacccgagcc ttctatgaag      720

attattgccg acattttcga atatacggct aagcatatgc ccaaatttaa ttcaatcagt      780

atttccgggt accatatgca ggaggccgga gctgacgcta ttctggagct cgcatatacg      840

ctggccgatg gattagagta ctcccggaca ggtctgcagg caggactgac aatcgacgag      900

ttcgcacctc gtctgtcttt tttttgggga atcggaatga atttctacat ggagatcgcc      960

aagatgcgcg ccgggagacg gctatgggcc cacctcatag aaaaaatgtt ccagccaaag     1020

aatagcaagt ccttgttact gagggcgcac tgtcagactt cagggtggtc tctcaccgaa     1080

caagacccct ataacaacat tgtacggacc gcaatcgaag cgatggcagc cgtgtttggc     1140

ggaacgcagt cccttcatac aaatagcttc gatgaagcgc tcggcctccc caccgtgaaa     1200

agcgcccgta tagcccgtaa tacacagatc atcatccagg aagaatcagg aattccaaaa     1260

gtggctgatc cctggggggg ttcttacatg atggagtgcc tgacaaacga cgtgtatgac     1320

gccgctctga aacttataaa tgagatcgag gaaatgggcg ggatggccaa ggcagtggcc     1380

gagggtatcc ccaaactgag gatcgaagaa tgtgctgccc gacggcaggc tagaattgac     1440

tctgggtctg aagtgatagt aggtgttaac aaataccagc tggagaagga ggacgccgtg     1500

gaggtcctcg cgattgacaa cacctctgtg cgcaatcggc agatcgaaaa gctgaaaaaa     1560

atcaagagta gtcgcgacca ggctttggcc gagaggtgcc tagccgcgtt aactgagtgt     1620

gccgccagcg gcgacggaaa tattctagca ctggccgtgg acgcttcccg ggccagatgc     1680

actgtcggtg aaattactga tgccctgaag aaggtgttcg gcgagcataa ggcaaacgac     1740

agaatggtga gcggagccta cagacaggag tttggggagt cgaaagaaat cacttcagca     1800

atcaaaagag tacacaagtt catggagcga gagggtcgac gtcctcgact cctggttgcg     1860

aaaatgggcc aagacggtca tgatcggggt gcaaaagtga ttgccactgg gttcgcagat     1920

ctcgggttcg acgtggacat tggaccattg ttccagactc ctagggaagt ggctcagcag     1980

gccgtcgacg cagatgtaca tgcagtcggc gtgtctacac tggccgccgg tcacaagaca     2040

ctggtgccag agctgattaa ggagctgaat agcctgggac gaccggacat tctcgtcatg     2100

tgcggcggtg tgatcccccc ccaggattac gaattcctgt tcgaggtagg ggtgagtaat     2160

gtattcggac cgggcaccag gattccgaag gccgcggtgc aggtactcga cgacatcgag     2220

aaatgtctgg agaagaagca acaatcagtt                                      2250


<210>  80
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  80
atgctcagag cgaaaaatca gctgttcctt ctgagcccac actatctacg gcaggttaaa       60

gagtcatccg gatccagact tatccagcag aggctgctcc accagcagca accattgcat      120

cctgagtggg ctgcgcttgc aaagaagcag ctaaagggca agaatcccga agacctcatc      180

tggcataccc ctgaagggat atctatcaaa cccctctata gtaaaagaga tacaatggat      240

ctccccgaag agttgcccgg cgtcaagcct ttcactagag gcccctatcc gaccatgtac      300

acctttaggc cctggactat tcgacagtac gccggatttt caaccgttga ggagagcaat      360

aagttttata aagataatat caaggccggt cagcaggggc tgtccgtggc ctttgacctg      420

gccacacacc ggggctacga cagtgataat ccccgggtaa gaggcgacgt gggtatggcc      480

ggcgtagcca ttgacaccgt ggaggacacc aagattcttt ttgatggaat tcctctagag      540

aagatgagcg tgagtatgac catgaatggg gccgtgattc cagttctggc aaatttcatt      600

gtgaccggag aggaacaggg ggtgcctaag gaaaagctca cggggacgat ccaaaatgac      660

atactgaagg agttcatggt caggaatact tacatctttc ctcccgaacc ttcaatgaag      720

attattgcgg atatctttga atataccgct aaacatatgc caaaattcaa ctccatctca      780

atttcggggt accacatgca ggaggcaggg gcagatgcca tactggagct cgcctacaca      840

ctggctgacg gcctagagta ctctaggact ggtttgcaag ctgggctcac cattgacgaa      900

ttcgcgccaa ggttgagttt tttttggggt atcggcatga acttttacat ggagattgcc      960

aagatgcgag ccggtcgacg cctttgggcg catctgatcg agaagatgtt tcagccaaaa     1020

aacagcaagt ccttattact tagagcccac tgccagacta gcggatggtc cctgacagag     1080

caggatcctt ataacaacat tgttcgtact gcgattgaag ccatggcagc ggtcttcgga     1140

ggaacccagt ctttgcacac aaattctttc gacgaagccc tgggcttacc taccgtgaaa     1200

tctgcacgga tcgcccgaaa cactcaaatc atcatccagg aggagtctgg catccccaag     1260

gtggctgacc cttggggagg gtcatacatg atggagtgcc ttactaatga tgtgtacgac     1320

gccgccttaa agttgattaa cgaaattgag gaaatggggg gcatggcaaa agctgttgca     1380

gaggggattc ccaagctgcg gatcgaggag tgtgctgccc gccggcaagc acggattgat     1440

tcagggtccg aagtaattgt gggcgtcaat aagtatcagt tagaaaaaga ggatgcagtc     1500

gaagtcctgg ctattgacaa tacaagcgtg agaaacaggc agatagagaa gttgaagaag     1560

atcaaatcta gcagagacca ggccctggca gaaagatgcc tcgcggctct caccgaatgc     1620

gctgcatctg gcgacggcaa cattctcgcc ctcgctgtgg atgcgagtcg cgcccgttgc     1680

acggttggag aaattaccga cgcactgaag aaggtgttcg gggagcataa agccaatgac     1740

cggatggtgt ctggggcgta cagacaggag ttcggcgaga gcaaagaaat cacttcagcc     1800

atcaaaagag ttcacaagtt catggagaga gagggaagac gaccgcggtt actggtggct     1860

aagatgggac aggatgggca cgaccgagga gcaaaggtca tagcaaccgg ttttgccgat     1920

ctggggttcg atgtggacat cggccctcta ttccagacac cgagagaagt ggcacagcag     1980

gccgtggatg ccgatgtgca cgcggtcgga gtgtctacac tggccgcggg ccacaagact     2040

ctggtaccag agctgataaa ggagctcaat tccctgggac ggcccgacat cctggtcatg     2100

tgtgggggag tgataccccc tcaggactac gaatttcttt tcgaggtcgg cgtttccaac     2160

gtctttggac ctggtacaag aattccaaaa gccgcagtgc aggtgttaga tgatatagaa     2220

aagtgcttgg agaagaaaca gcagtccgtg                                      2250


<210>  81
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  81
atgctcagag cgaagaatca actttttctg ctttcacctc attacctgcg gcaggtgaag       60

gaaagctcag gaagtaggct gattcagcag cgcctcctgc atcagcagca acccctgcac      120

ccagaatggg ccgcactggc taagaagcaa cttaaaggaa agaatcccga ggacctgatc      180

tggcacaccc ccgaaggaat tagtatcaaa ccactgtatt ccaagcggga caccatggac      240

ttgccggagg agctgcctgg agttaagcca ttcacgagag gcccttaccc tactatgtat      300

acgttcagac cttggaccat ccgacagtac gctggctttt ctaccgtgga agagtccaac      360

aagttctaca aagacaacat caaagccggc cagcagggac tgagcgttgc ctttgaccta      420

gcgacacacc ggggctacga ttctgataat ccgcgggtcc gtggcgatgt cggaatggcc      480

ggggtggcta ttgacacagt tgaggacact aagattcttt ttgacggcat cccacttgaa      540

aaaatgtccg tttctatgac tatgaacggg gccgtcatac cagtcctggc aaatttcatc      600

gtgaccggcg aggaacaggg cgtgcctaaa gagaagctca ctggtacgat ccaaaatgac      660

atcctgaagg aatttatggt tcggaacacc tacatcttcc ctccggagcc ctcaatgaaa      720

attatcgctg atatttttga atacaccgca aagcatatgc ctaaatttaa ttctatctct      780

attagcgggt atcacatgca agaagctggc gcagatgcaa tcctagagtt ggcctatact      840

ctggctgatg gactggaata ctctagaacc ggtttacagg ccggactgac aatcgatgag      900

ttcgccccta ggctcagctt tttttgggga atcgggatga atttttatat ggagatcgct      960

aagatgaggg caggtcgaag gctatgggcc catctcatcg agaagatgtt tcagcctaag     1020

aattcaaaat cattgctcct tcgtgcccat tgtcagacgt ctggctggag tcttacggaa     1080

caggatccct ataataacat cgtgcgcacc gcgattgaag ccatggctgc ggttttcggc     1140

ggaacccagt ccctccacac aaactcattt gacgaggcgt tgggacttcc tacggtaaag     1200

tccgcccgga tagccaggaa tacccagatc attatacagg aagaatcagg gataccgaaa     1260

gttgcggacc cttggggcgg tagttacatg atggagtgtc tcacaaacga cgtctatgat     1320

gcggccctca aacttatcaa cgaaatagag gaaatgggtg gaatggcaaa agccgtggcc     1380

gaaggaattc ctaaattacg gatcgaggag tgtgcagcac gacggcaagc tcggattgat     1440

agtgggtccg aggtgatcgt gggggttaat aagtatcagc tggaaaaaga agacgccgta     1500

gaagtcctcg ccatcgacaa tacaagcgtg agaaacaggc agatcgagaa actaaaaaag     1560

attaaatcaa gcagggacca ggcgctggca gaacgctgcc tggccgccct cacagagtgt     1620

gccgcttcgg gggacggcaa tattctggcc ctggcggtcg atgccagccg agcaagatgt     1680

accgtcgggg agattacaga cgcgttgaaa aaggtgttcg gcgagcacaa agctaacgac     1740

agaatggtga gcggagccta cagacaagag tttggggaga gcaaggagat aacatccgca     1800

ataaagaggg tgcataagtt tatggaaagg gaggggaggc ggccccggct cctggtggcc     1860

aaaatggggc aggacggtca tgacaggggg gccaaagtga tcgcaacggg gtttgccgac     1920

ctggggttcg atgttgacat aggtccactt tttcagactc ccagggaagt ggcgcagcag     1980

gccgtcgacg cggacgttca cgccgtggga gtgtcaacac tggccgctgg tcataagact     2040

ctggtgccag aactcataaa agagctgaac tccctcggcc gacctgatat tctagtgatg     2100

tgcggtggcg taatcccccc ccaggattat gaattcttgt tcgaagtggg agtaagcaac     2160

gtgttcgggc ctggcacaag aattcctaaa gccgctgtcc aagttttaga tgatattgag     2220

aaatgcctag agaaaaagca acagtccgtg                                      2250


<210>  82
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  82
atgttaaggg ctaaaaacca attatttttg ctgagtccgc attacctcag acaggtgaaa       60

gagtctagcg gaagtcggct tatccagcaa aggttgctgc accagcagca gcctctgcac      120

cctgagtggg cagccctggc caaaaaacag cttaagggaa agaatccaga agacttaatc      180

tggcacaccc ccgaaggaat ctccataaaa ccgctctact ccaaacgcga caccatggat      240

ttgccagagg agctcccagg cgtgaagcct ttcacaaggg gcccttaccc cacgatgtac      300

acttttcggc catggacaat tagacagtac gctggatttt caactgtgga agagagtaac      360

aaattttata aagataatat aaaggccggc caacaggggt tgagtgtcgc attcgactta      420

gcaacccacc gaggctatga tagtgacaat ccgagagtga ggggtgacgt gggtatggcc      480

ggtgttgcta tcgacactgt cgaagacact aaaattctct tcgacggcat tcccctcgag      540

aaaatgtcag tgtctatgac gatgaacggc gctgtgatac cagtgctcgc caacttcatt      600

gtaacaggcg aggagcaggg tgtgcccaaa gaaaaactga caggaaccat acaaaatgat      660

atccttaagg agtttatggt ccgaaacaca tatatcttcc caccggaacc aagcatgaaa      720

attatcgccg atatattcga atacacagcg aagcatatgc ccaaatttaa tagtatctca      780

atttcgggct atcatatgca ggaggccggg gccgacgcaa ttctcgagct ggcttataca      840

ctggccgacg gtctggagta ttctcggact ggcctccagg cagggttgac tatcgacgaa      900

ttcgcaccac gcctgtcctt cttttggggc atcggaatga acttctacat ggagattgcg      960

aaaatgagag ccggccgccg actgtgggca catcttattg agaagatgtt tcagcccaaa     1020

aatagcaaaa gcctgctgct tcgggcccat tgccagacta gcggttggtc cctcaccgag     1080

caggatccct ataataatat cgtgcggacc gccatcgagg ccatggccgc cgtatttggt     1140

ggaactcaaa gtcttcacac aaattcattt gatgaggcgc ttggcctccc tacagtgaaa     1200

agcgcacgca tagctcgcaa tacccagatt attatacagg aagaatcagg cattcctaag     1260

gtagctgacc cctggggagg ctcctacatg atggagtgtc tcaccaatga cgtctacgac     1320

gctgctctga aactcatcaa tgaaattgag gagatgggag gcatggctaa ggccgtcgcc     1380

gaagggattc ctaagctacg cattgaggag tgcgccgccc ggcgccaggc acggattgac     1440

tcgggatctg aggttattgt cggtgtgaac aaataccaac tggagaaaga agacgctgtg     1500

gaggttctcg ctatcgataa cacatcagtc agaaaccgac agatagaaaa gctgaaaaaa     1560

atcaagtcat ccagagacca ggctcttgcc gaaaggtgtc tggctgctct cacagaatgt     1620

gctgcttccg gagatggcaa tatactggcc ctggctgtag atgcgagccg ggctagatgt     1680

accgtcgggg agattacaga cgcgctcaag aaggtcttcg gcgaacacaa agctaacgac     1740

aggatggtaa gcggagccta ccgacaggag tttggtgaat caaaggagat tacctccgcg     1800

atcaaacgag tccacaaatt tatggagaga gagggccgca gacctaggct cctcgtggca     1860

aaaatgggcc aggatggaca tgatagggga gccaaagtta tcgccactgg ctttgcagat     1920

cttggtttcg acgtggatat tgggcctctg tttcagactc caagggaagt ggcacagcag     1980

gcagtggacg ctgatgttca cgcagtgggt gtgtcaacgc tggccgccgg ccataagacc     2040

cttgtccccg agctaatcaa ggagctgaat tctctgggga ggccagacat tctggttatg     2100

tgcggaggag taataccacc tcaggattat gagttcctct ttgaggtcgg cgtcagcaac     2160

gtttttggcc cgggcacacg aatcccgaag gcagctgtgc aagtattgga cgatatagag     2220

aagtgcctgg agaagaagca gcagtccgtg                                      2250


<210>  83
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  83
atgctgagag ccaagaatca attgtttctg ctgtcacctc actacctccg gcaggtaaaa       60

gaaagctcag gctctcgcct tattcagcag aggttgctcc atcaacaaca gccccttcat      120

cctgaatggg ctgcactggc aaagaagcaa ttgaagggga aaaatcctga ggatttgatc      180

tggcacaccc ccgagggcat tagcattaaa cccctgtatt caaaacgcga cacgatggat      240

ctgccagagg aactgcctgg agtaaagcca tttactcgcg gaccataccc taccatgtat      300

acattccgac cctggacaat ccggcaatac gccggtttta gcaccgtgga ggagagcaac      360

aagttttata aggacaatat caaggcaggc cagcagggct tgagcgtggc ctttgatttg      420

gccactcaca gagggtacga ttccgataac ccaagggtta ggggcgatgt ggggatggca      480

ggagtggcga ttgatacagt ggaggacact aagattctgt tcgatgggat acctttggag      540

aaaatgagcg tcagcatgac gatgaacggg gcagtgatac ctgttcttgc caacttcatt      600

gtaaccgggg aggaacaggg tgttcctaag gagaaactaa ccggaacgat acagaatgac      660

attcttaagg aattcatggt tcgtaacact tacatctttc cacctgagcc ctcaatgaaa      720

attatagccg acattttcga gtatactgcc aagcatatgc ccaaattcaa ttcgattagc      780

atcagcgggt atcacatgca ggaagcggga gctgatgcga tcctggagct cgcctatact      840

cttgctgatg ggctggagta ctcacgaaca gggttgcagg ccgggcttac tattgacgag      900

ttcgcgcctc gattgtcatt tttctggggc attggcatga acttctacat ggagatagcc      960

aaaatgagag cgggacgcag gttgtgggcc cacctgattg agaagatgtt tcagcccaaa     1020

aatagcaagt ctcttttgct acgggcgcac tgccaaacaa gtggatggtc actgactgag     1080

caggacccat acaacaacat cgtccggact gccatcgaag ccatggccgc cgtttttggc     1140

ggcacccagt cgttgcacac caattccttt gacgaagcct tgggccttcc aactgtaaag     1200

agcgcacgga tagctaggaa tacgcagatt attatccagg aggaatctgg gatacccaaa     1260

gtcgccgacc cttggggagg aagttacatg atggagtgct taacaaatga cgtttatgat     1320

gctgccctca agctcatcaa cgagatagaa gaaatgggag gaatggcgaa ggccgtcgcc     1380

gaggggattc caaagttgcg tattgaggag tgtgccgcca gaagacaggc ccggattgac     1440

tcaggctccg aggtcatcgt cggggtgaat aagtaccagc tggaaaaaga agatgcagtg     1500

gaagtcctcg ccatagataa tacctctgta cggaataggc agattgagaa acttaagaaa     1560

attaagagca gccgggacca agcccttgcc gaaaggtgtc tcgccgcttt gacagagtgc     1620

gccgcgagcg gagatggcaa tattctggct ctggccgtgg atgccagccg cgcgcgctgc     1680

actgttgggg aaattacgga tgccttaaaa aaagttttcg gggaacacaa ggctaacgac     1740

agaatggtct ctggggcgta ccgccaggaa tttggcgaga gcaaagaaat taccagcgct     1800

attaagaggg tgcataagtt catggagcgg gagggtagac gccctagact ccttgtcgcc     1860

aaaatgggac aggacggaca cgaccgcgga gccaaggtga ttgcaacggg ctttgctgac     1920

ctgggctttg acgtcgatat cggccctctg ttccagactc cacgcgaagt cgcccagcag     1980

gccgtcgacg ctgatgttca tgccgtagga gtgtccacac tcgcggcggg gcacaagact     2040

ttagtacccg agctgattaa ggagctgaac agcctgggga gaccagacat cctcgtcatg     2100

tgcggcgggg ttattccacc tcaggactac gagtttttat tcgaagtggg ggtatctaac     2160

gttttcggac ctggtactcg tattcccaag gccgctgttc aggtcctgga cgacattgag     2220

aagtgcctgg agaagaagca acagtctgtt                                      2250


<210>  84
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  84
atgctcagag cgaaaaacca gcttttcctc ctttctccgc actatctgcg acaggtcaaa       60

gaaagttctg ggtctcgtct gattcagcaa cgcctactgc accagcagca gccactgcac      120

cccgagtggg cagcgcttgc caagaagcag cttaagggaa aaaacccaga ggatctgatc      180

tggcacaccc ccgagggaat tagcataaag cctctgtatt ccaagcggga tacaatggac      240

ctccctgagg agcttcccgg cgtgaagcca ttcacccgtg ggccctatcc gaccatgtac      300

actttcagac cctggaccat tcgacagtat gctgggttca gtaccgtaga agagagtaac      360

aagttttata aggacaatat caaggccggc cagcagggcc tatccgttgc ctttgatctg      420

gcgacgcacc ggggctatga cagcgacaac ccaagggtcc gcggggacgt gggaatggcc      480

ggtgtcgcca tcgatacagt cgaagacacc aaaattctgt ttgatggcat tcctctggaa      540

aaaatgtctg tgagtatgac tatgaacggg gccgtgatcc ccgttcttgc taactttatt      600

gtaacggggg aggagcaggg cgtaccaaaa gaaaagctca cagggactat tcagaacgac      660

atccttaaag agtttatggt aagaaatact tatatctttc ctcctgagcc ttcgatgaag      720

ataatcgccg acatttttga gtatactgca aagcacatgc ctaagtttaa ttccatcagt      780

atcagcggtt atcatatgca ggaggctgga gctgacgcca ttctagaact tgcctacacc      840

ctggccgatg ggttggagta cagtaggaca ggtttgcagg ctggcttaac aatcgatgaa      900

tttgccccta ggctgtcctt cttctggggc ataggcatga acttttacat ggagatagct      960

aaaatgcgcg ctggcagaag gctgtgggcc catctgattg agaagatgtt tcaaccaaag     1020

aacagtaaga gcctactctt gcgggcccac tgccagactt cgggctggag cctgacagag     1080

caggacccct acaacaacat cgtccgcact gccatcgaag ctatggccgc tgtattcggc     1140

ggcacgcagt cccttcacac caactcgttc gacgaggctc tcgggctgcc tactgtcaag     1200

tcagccagga tagcaaggaa cacacagatc atcattcaag aggaaagcgg cattccaaag     1260

gttgctgacc cgtggggagg ctcctacatg atggaatgcc tgaccaacga cgtttatgat     1320

gctgcactca agttgatcaa cgaaatcgaa gagatgggcg gaatggctaa agctgtggcc     1380

gagggcattc cgaagcttag aatagaggaa tgcgccgcca gacggcaggc ccgtatcgac     1440

agtggctctg aagtaattgt cggtgtcaat aaataccagc tggaaaagga agacgcagtt     1500

gaagtcctgg caatagacaa tacaagcgtt cggaacagac agattgagaa actaaaaaag     1560

ataaagtctt ctcgggatca ggccctagcg gaacgttgcc tggctgccct taccgagtgc     1620

gcagcctctg gcgacgggaa catcttagcc ttggcagtgg acgcgtcacg cgcaagatgt     1680

accgtgggcg aaattacaga cgccttgaaa aaagtttttg gtgaacacaa ggcaaatgac     1740

cgtatggtga gcggggccta ccggcaagag ttcggggaga gcaaagagat aacgagcgca     1800

attaaaaggg tgcataagtt tatggagagg gaaggtcgcc ggccgagact gctggtagcc     1860

aaaatggggc aggacggcca tgatcgaggc gctaaagtga ttgctaccgg cttcgctgat     1920

ctggggtttg acgttgacat tgggccattg ttccagactc ctagagaggt ggcccaacag     1980

gctgttgatg cggacgtgca cgctgtaggc gtgtcaacat tagctgctgg acacaagact     2040

ctcgtgcccg aactgatcaa ggagcttaat tcattgggaa ggcccgatat ccttgtcatg     2100

tgcggaggag tgattccccc ccaagattac gaatttctct tcgaggtagg agtcagtaac     2160

gttttcggac cagggacgag aatccccaag gctgccgtgc aggtgttgga tgatattgag     2220

aagtgcctcg aaaagaagca gcagagcgta                                      2250


<210>  85
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  85
atgctccgcg ccaagaatca gctgttcttg ctcagtccac attatctgag gcaggtcaag       60

gaatcctccg ggagcagact gatccagcag agactgcttc accagcaaca acctctgcac      120

ccagagtggg cggcgctcgc taagaagcag ctgaaaggta agaaccccga agatctgatc      180

tggcacaccc cggaggggat ctccattaag cctctttatt ccaaacggga caccatggat      240

ttgcctgaag aactgcccgg tgtcaagcca ttcactcggg ggccctaccc taccatgtac      300

acattccggc cttggactat ccgacagtac gcagggtttt ccaccgttga ggaaagcaat      360

aaattctata aggataacat caaagccggt cagcaaggcc tctccgtcgc ttttgatctc      420

gccacacatc gcgggtatga ttcagataat ccacgagtca ggggggatgt cgggatggca      480

ggagtcgcta tagatacagt cgaagatacc aagatattgt ttgacggtat tcctcttgaa      540

aagatgtcag tttctatgac gatgaatggt gccgtcatac cagtactggc aaatttcatt      600

gtaactgggg aggaacaggg agtgcccaag gaaaagctta ctggcacaat tcagaatgac      660

atccttaaag aatttatggt gcggaacacc tatatctttc cacctgaacc cagtatgaaa      720

attatcgctg atatctttga atatactgcc aaacacatgc caaagttcaa ctctatatct      780

atcagcggtt atcatatgca ggaagccgga gccgatgcga ttctggaact ggcctacacc      840

ttggctgatg gcctggaata ctctcgcact ggtctgcaag ctggcttgac aattgacgag      900

ttcgccccac ggttgtcctt tttttggggc attggaatga atttttacat ggaaatcgcg      960

aaaatgcgcg ctggcaggcg gctctgggcc caccttattg agaagatgtt ccagccaaaa     1020

aattcgaagt ccctgctgtt gcgagcccac tgccaaacaa gtggatggag tctcactgag     1080

caagaccctt acaataacat cgtccggaca gctatcgagg cgatggctgc cgtgttcgga     1140

gggacccagt ctcttcatac aaactctttt gacgaggccc tgggactccc cactgttaag     1200

agtgctcgca ttgctcggaa cactcaaatc atcatccaag aggaatccgg tatccccaaa     1260

gtcgccgatc cctggggagg ctcatatatg atggaatgtc tgaccaacga cgtgtacgat     1320

gcggctctca agctgattaa tgagattgaa gagatggggg gaatggctaa ggccgtggcc     1380

gagggaattc cgaagctgcg catcgaggag tgtgcggcca ggagacaggc ccggatcgac     1440

agcggaagtg aagtgatagt gggcgtcaat aagtatcagc tagagaaaga agacgccgtg     1500

gaggttctag ctatcgacaa cacgtccgtg cgtaacaggc agattgagaa actcaagaaa     1560

attaagagct cccgcgatca ggccttggct gagagatgct tagccgccct gactgaatgt     1620

gctgcctccg gggacggtaa tatcctcgcc ctcgctgttg atgcttcaag ggcgcgttgc     1680

actgttggcg agattaccga cgctctaaaa aaggtgttcg gggagcataa agctaacgac     1740

cggatggtgt ccggtgcata cagacaagag ttcggtgaga gcaaggagat tacttccgca     1800

atcaagcggg tgcataagtt catggaaagg gaaggtcgga gaccaaggct ccttgtcgcc     1860

aaaatggggc aggatggaca cgacagggga gccaaggtga ttgctacagg tttcgccgac     1920

ttgggtttcg atgtagatat tggacccctt tttcaaacac ccagagaggt ggctcagcag     1980

gccgtcgacg ccgatgtgca cgcagtgggg gtgtccaccc tcgccgcagg gcacaagacc     2040

ctcgtacccg aattgattaa ggagcttaac tccctgggca gacctgacat tttggttatg     2100

tgtggtggtg tgataccgcc acaggattac gaattcctgt ttgaggtggg agtgagcaac     2160

gtattcggcc ccggcaccag gatcccgaag gctgccgtac aagtgttgga tgacatcgag     2220

aagtgcctcg agaagaaaca gcagtctgtc                                      2250


<210>  86
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  86
atgcttaggg caaaaaacca gttattcttg ctgagcccgc actatttgcg tcaagtcaag       60

gagtctagcg ggtccagact gattcagcag cgactgctgc atcagcagca acctctccac      120

cccgagtggg ccgctttagc caaaaaacag ttaaaaggca aaaatcccga agacctgatc      180

tggcacactc cagagggcat tagcatcaaa cccctgtatt ctaaacgcga taccatggac      240

cttccagagg aactgccagg cgtgaagccg ttcacacgtg gaccttatcc cactatgtac      300

accttccgcc catggactat tcggcagtac gccggttttt ctacggttga agaaagcaat      360

aagttctata aagataatat caaagccgga cagcagggac tgtctgttgc attcgacctg      420

gccactcaca gagggtatga ctcagataat cccagagtca gaggtgacgt tggcatggcc      480

ggggtggcta ttgatacagt cgaagacaca aaaatactgt ttgacggaat ccccctcgaa      540

aaaatgagcg tctcaatgac gatgaacggt gccgtgatac ccgtccttgc gaatttcatt      600

gtcacaggag aagagcaggg ggtcccaaaa gaaaaactaa caggtacaat tcagaatgac      660

atcctgaagg aattcatggt tcgcaacact tacatctttc cccctgaacc ctcgatgaag      720

atcatcgccg acattttcga atataccgca aaacacatgc ctaagttcaa ctccatctcc      780

atcagcgggt accacatgca ggaagccggg gctgacgcga tcctggagct ggcatacact      840

ctcgccgatg gcttagagta ttccagaacc ggcttgcagg caggcctgac aatagacgag      900

tttgcgccac ggctgtcttt cttctgggga atcggcatga acttttacat ggagatagca      960

aagatgagag cagggcggcg cttgtgggct catctgatcg agaaaatgtt ccagccgaag     1020

aacagcaagt ccctgctgct gcgggcccac tgtcaaacct ctggttggag cctgacagag     1080

caggatcctt acaataatat agtgcgaaca gcgattgagg caatggctgc tgtgttcggc     1140

ggaacacaga gtctgcatac aaactctttt gacgaggccc ttggcctgcc aacagtgaaa     1200

agcgctagaa tcgcccggaa tactcagatc ataatccagg aagagagtgg aatccccaaa     1260

gtggcagatc cttggggtgg gagttatatg atggaatgtc tgaccaatga tgtctacgat     1320

gccgctctca agctgattaa tgaaatcgag gagatgggtg ggatggccaa ggctgtcgcc     1380

gagggtatcc ccaaactcag gattgaggag tgcgctgccc ggagacaggc gcgaatcgat     1440

tcgggctctg aggtgatcgt gggcgtgaac aagtaccagc tagagaagga ggacgctgtg     1500

gaagtcctgg ccattgataa taccagtgtg cggaacaggc agatcgaaaa attaaaaaaa     1560

attaaaagta gtcgcgacca agcactggca gagcgctgct tggcggccct gacggagtgc     1620

gcagcctctg gagatggcaa tatcctggca ctggccgtcg acgcctcaag agctcgatgc     1680

accgtaggcg agatcaccga cgccctgaag aaggtcttcg gagaacataa agccaatgac     1740

cggatggtga gcggcgccta taggcaggag tttggggaga gtaaagagat cacatctgca     1800

ataaagcgtg tgcataagtt tatggaaagg gagggaaggc gcccacgact ccttgttgct     1860

aagatgggtc aagacggcca tgaccgcggc gccaaagtca tcgcaaccgg gttcgctgac     1920

ttggggtttg acgtcgatat cggacccctg tttcagacgc cacgggaagt agctcagcaa     1980

gccgtggacg cggatgtgca cgccgtaggc gtgtctacct tggcagcagg ccataaaacc     2040

ctagtgcccg agctcataaa agagctgaac agcctgggac ggcctgacat cctagtgatg     2100

tgcgggggcg tcatcccacc tcaggattat gagttcctct tcgaggtggg agtttccaat     2160

gtgtttggac ccggcacacg aatccccaaa gcagccgtgc aggtgttgga tgacatcgag     2220

aaatgcttag aaaagaaaca acagtccgtc                                      2250


<210>  87
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  87
atgctgcgcg caaaaaacca actgttcctc ctgagcccac actatttgcg acaggtcaaa       60

gagtcctctg gatcaaggtt aatccagcaa cggctcctgc atcagcagca gccactccac      120

cccgagtggg ccgcccttgc aaagaagcag ttaaaaggca aaaatcccga agatctgatc      180

tggcacacac cagagggaat cagcatcaag ccgctttaca gtaaaaggga cactatggat      240

cttcctgagg aactcccagg cgtgaaaccc ttcacgaggg gcccttatcc cactatgtat      300

acctttagac cctggaccat taggcaatac gccggattct cgaccgtgga agagtctaat      360

aagttttaca aggacaatat taaggcaggg cagcaggggt tgagtgtcgc ctttgatctc      420

gcaacacata gggggtacga cagtgacaat ccaagggtcc gaggtgacgt ggggatggcg      480

ggcgtggcca tcgacactgt ggaggatact aagattctgt tcgatggaat ccccctggag      540

aaaatgtcag tctccatgac aatgaatggt gctgtaattc ctgttctggc taactttatt      600

gtgaccgggg aagagcaggg agttcccaag gaaaagctaa ctggcactat tcaaaatgat      660

atccttaaag aattcatggt ccgaaatacc tatatatttc cacctgagcc atctatgaaa      720

ataattgcag atatctttga gtatactgct aagcatatgc caaagttcaa cagtattagc      780

attagtgggt accacatgca ggaagctggg gctgatgcaa ttctggaact tgcgtatacc      840

ttggccgatg gactcgaata cagccggacc ggcctgcagg ccggactgac aatagatgag      900

ttcgctccac gcctttcttt cttttggggc attggaatga acttctacat ggaaattgca      960

aagatgcggg ctgggagaag gctatgggct cacctcatcg aaaagatgtt tcaacccaaa     1020

aatagcaagt ctctcctcct gcgggctcac tgccagacca gcgggtggtc tctcaccgag     1080

caagaccctt acaataacat cgtgagaact gccattgagg cgatggctgc tgtgtttggt     1140

ggtacccaat cacttcacac gaactctttt gacgaggccc ttgggctgcc aaccgtgaag     1200

agcgctcgga ttgctcgcaa cactcagatt ataattcagg aggagtcagg catccccaag     1260

gtggcggacc cttggggagg aagctacatg atggagtgcc tgaccaacga cgtgtacgat     1320

gcagctctga agctgatcaa cgaaatcgaa gaaatggggg gtatggccaa ggccgtggcc     1380

gaagggattc ctaaactgag aattgaagaa tgtgctgctc gccggcaggc cagaattgat     1440

agcgggtcag aggtgatcgt gggggtgaac aagtatcaat tggagaagga agacgccgtc     1500

gaggtgttag caatagataa tacttctgtc agaaatcgtc agatcgaaaa gctcaaaaag     1560

atcaaatcct ctcgggatca ggctcttgct gagaggtgcc tcgctgccct gactgaatgc     1620

gccgcttcgg gcgacggtaa tatcctggca ttagctgtgg acgcctcacg ggcgcgttgc     1680

accgtaggtg agattacaga cgcccttaag aaggttttcg gggagcacaa ggcaaacgac     1740

cgaatggtga gcggggctta caggcaggag ttcggagagt caaaagagat tacatctgcc     1800

atcaagcgcg tccataaatt catggagcgc gagggacgca gacccagact gctcgtcgct     1860

aaaatgggac aggatggcca cgaccggggc gccaaagtca tcgccaccgg cttcgccgac     1920

ctgggcttcg acgtggatat aggtccgcta ttccaaactc ccagagaagt tgcccagcag     1980

gcagtggatg ccgacgtgca cgctgtcggg gtctccaccc tcgctgcagg ccataaaacc     2040

ttggttccgg agttaattaa agaacttaac agcctaggac gccctgatat cttggtgatg     2100

tgtgggggtg tgatcccacc ccaggactat gaattcctgt tcgaggtcgg agtgtccaat     2160

gtgttcgggc ccgggacccg aatacctaag gccgcagtgc aagtgttgga tgatattgaa     2220

aagtgtctag aaaaaaaaca gcagtctgtt                                      2250


<210>  88
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  88
atgctgcgcg caaagaacca gctgttttta ctgtcacctc attacctgcg ccaggtcaaa       60

gaatctagtg gatccagact gatacaacag cgtctgctgc accagcaaca gcctttacac      120

cctgagtggg ctgccctcgc taaaaagcag ctgaagggaa agaatccaga ggatcttatt      180

tggcacacac ctgagggcat atcaatcaag cctctttata gcaagaggga tacgatggac      240

ttgcctgaag aactccccgg cgttaagccc ttcaccaggg ggccatatcc aactatgtat      300

acgttcagac cctggactat tcggcagtac gccggattct ccaccgtgga agaatcaaat      360

aagttctaca aagataacat caaagcaggc cagcagggcc tgagtgtcgc tttcgatctc      420

gctacacatc gcggctacga ttcagacaac cccagagtga ggggagatgt gggcatggca      480

ggggttgcta ttgatacagt ggaggatact aagatcctgt tcgacggcat ccctcttgaa      540

aagatgtcag tgagcatgac aatgaacggc gccgtgatac cagtcctggc aaattttatc      600

gtgacagggg aagagcaggg tgtgcctaag gagaaactga ccggtactat ccagaacgac      660

atccttaaag aatttatggt gcggaatacc tatatttttc ccccagaacc aagtatgaaa      720

attatagcag acatcttcga gtacacggcg aaacatatgc ccaagttcaa ttcaatcagc      780

atctctggtt accacatgca agaagctggg gccgacgcta tcctggaact cgcttacact      840

ctggcagacg gactagagta ttcacgcaca ggcctgcaag caggattgac catagatgag      900

ttcgccccca ggctgtcttt cttctggggt atcgggatga acttttatat ggagatcgca      960

aagatgcgcg ccggacgtag actatgggcg cacctcattg agaaaatgtt ccagccaaag     1020

aactccaaga gcctgcttct tagggctcac tgccagacta gtggctggag cctgaccgaa     1080

caggaccctt ataacaacat cgtccgcact gccatcgaag ctatggctgc agtctttggg     1140

ggtacacagt ccctccacac caattctttc gacgaagccc tgggcttgcc gaccgtcaag     1200

agcgctcgta tcgcgagaaa tacccagatt attatccaag aggaatccgg catccccaag     1260

gtggctgacc cttggggcgg aagctacatg atggagtgtc ttactaatga cgtatacgat     1320

gctgccctga agctcattaa tgaaatagaa gaaatgggag gtatggcaaa agctgtggca     1380

gagggcatac cgaagctgag aatcgaggag tgtgccgcac ggcgtcaggc caggattgat     1440

agcggttccg aagtgatcgt cggagtgaac aaataccaac tcgaaaaaga ggacgcagtc     1500

gaggttttgg ccatcgacaa cacttccgtt cgtaaccggc agattgagaa gcttaagaag     1560

atcaaatcta gccgcgacca ggctctcgcc gaacgttgcc tggcggccct caccgagtgc     1620

gcagcatccg gagatggtaa tatcttagca ctggctgtgg acgcctcccg cgcccggtgt     1680

actgtagggg agatcacgga tgccttaaag aaagtctttg gcgaacataa ggcaaacgac     1740

aggatggtaa gcggagctta ccggcaggaa ttcggggaat caaaagaaat caccagtgct     1800

atcaaacggg tgcataagtt catggagcgg gaaggacgcc gcccacgact actcgtggcc     1860

aagatggggc aggacggaca tgaccgagga gccaaagtaa ttgctaccgg tttcgctgac     1920

ctggggttcg atgtggatat cgggccactc tttcagactc ctcgcgaggt cgctcagcaa     1980

gctgttgacg cggatgtcca cgctgtcggt gtctccactc tagcagccgg ccacaaaacg     2040

ttggtgcccg aactaattaa agaactgaat tcactgggaa gacccgacat attggtcatg     2100

tgcggagggg tgattccacc ccaggactat gagttcctgt ttgaagtggg cgtttcaaac     2160

gtattcggac cagggacccg gattcccaag gctgccgtgc aggtgctcga cgatatagag     2220

aaatgcctgg agaagaagca gcagagtgtg                                      2250


<210>  89
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  89
atgctgcggg ctaagaacca gttgtttctg ctgtcaccac attatctgcg ccaggttaag       60

gaatctagcg gctcaagact gattcagcag cgccttctgc accagcaaca acccctgcat      120

ccagagtggg ccgcgctcgc aaaaaaacag ttaaagggga agaacccaga ggatctcatc      180

tggcatacgc ccgagggtat ttcgattaag cccttgtatt ctaagagaga taccatggac      240

ttgccagaag agcttcctgg agttaaacca tttacacgag ggccctaccc cactatgtat      300

acgttcaggc cctggactat tagacagtac gcaggtttca gtactgtgga agagtcaaat      360

aagttctata aagataatat caaagccggt caacaggggt tgtcagtggc tttcgatctg      420

gctacccatc ggggttacga cagtgataac cctagggtaa gaggggatgt cggaatggcc      480

ggcgtggcca tagacactgt ggaggataca aaaatcctgt tcgacgggat tcctctcgag      540

aaaatgagtg ttagtatgac gatgaatggc gccgtcatac cagtcctcgc caattttata      600

gtgactgggg aagaacaggg ggtgccaaaa gagaagttga ccggaaccat ccagaacgat      660

atattaaaag agttcatggt tcgaaatact tacatttttc ctccggagcc ttcaatgaaa      720

attatcgccg atatctttga gtacacagca aaacacatgc caaaattcaa cagcatctca      780

ataagcgggt atcatatgca agaggccggt gctgatgcaa ttctcgagct cgcctacact      840

ctggctgatg gcctcgagta ttcccgcacc gggctccaag ccggcctgac gattgatgaa      900

ttcgctccaa ggctgtcttt tttctggggc atcggaatga atttctacat ggagattgct      960

aagatgagag cagggaggcg cctttgggca cacctaatag agaagatgtt ccagcccaaa     1020

aactccaaat ctttgctgct gcgcgcacat tgtcagacta gtggttggtc cctgactgag     1080

caagatccct acaacaacat agtgcgaacc gccattgaag ccatggcggc cgtctttggg     1140

ggcacgcaga gcctgcacac caattccttt gatgaagctt tgggcctgcc aacagtcaag     1200

tctgcacgga ttgcacggaa cacccagatc atcatacagg aggagagcgg gataccaaaa     1260

gttgccgatc cctggggagg atcctacatg atggagtgtt taacaaacga cgtgtacgac     1320

gcagccctga aattgataaa cgagattgag gagatgggag gcatggccaa agccgtcgct     1380

gagggcattc caaaacttcg catcgaagaa tgtgctgccc gtcggcaggc ccgaatcgac     1440

tctggttctg aggtgatcgt tggagtgaac aaatatcagc tcgagaagga agatgccgtg     1500

gaggtactgg ccatagacaa cacatccgtc cgaaaccgac agatcgagaa gttaaagaag     1560

attaagagtt cccgagacca ggcgctggcc gaacggtgtc tagctgcctt gacagagtgt     1620

gctgcgtccg gggacggtaa tatactggcc ttagcagttg acgcttcgag agccaggtgt     1680

acagtggggg agatcactga tgccttaaaa aaggtcttcg gtgagcataa ggctaacgat     1740

cggatggtat cgggggccta cagacaagag ttcggcgagt cgaaggagat tactagcgca     1800

attaagaggg tccacaaatt catggagcga gagggtagga ggcctcggct cttagtcgca     1860

aaaatggggc aagatggcca cgatcgagga gccaaggtga ttgctaccgg atttgctgat     1920

ctaggcttcg atgttgacat tgggccgttg ttccaaacgc cccgggaggt ggcacagcaa     1980

gccgttgacg cagacgtgca tgccgtcggt gtgagtaccc ttgctgcagg acataaaact     2040

cttgttcctg agcttataaa agagttgaat tctctgggtc gccctgacat cctggtcatg     2100

tgcggaggtg tcattccgcc ccaagattac gaattcttgt ttgaggtcgg ggtaagtaat     2160

gtgttcggcc caggtacgcg gattcctaaa gctgctgttc aggttctgga tgatatcgag     2220

aaatgcctcg agaaaaaaca gcagagtgtc                                      2250


<210>  90
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  90
atgctgcggg caaaaaatca attatttctt ctgtcccccc actaccttag acaagtcaaa       60

gaatcctcag gtagccgtct tattcagcag agattgttac accaacagca gcccctgcac      120

cctgagtggg cagcacttgc caagaagcag ctcaagggga aaaatccaga ggatctgatt      180

tggcatacac ctgaaggaat ctccatcaag cccctatatt ctaaacggga cactatggac      240

ctgcctgagg aactcccagg ggtgaaaccg tttaccaggg gaccctaccc aaccatgtat      300

accttccggc cctggacaat ccgtcagtac gccggttttt ctaccgtcga ggaatccaat      360

aagttttata aagataacat caaggctggc cagcaaggcc ttagcgtggc ctttgatctg      420

gctacccatc gggggtacga ctccgataac ccccgtgtga gaggagacgt aggcatggca      480

ggggtggcta tcgacaccgt cgaggacacg aagatactgt ttgacggaat tcccctggaa      540

aagatgtcag tgtccatgac catgaatggc gcggtgatcc cagttctggc caacttcatc      600

gttacaggag aagaacaggg cgtgcccaag gagaagctga ccgggactat tcaaaatgat      660

attctcaaag aatttatggt gcgcaatacc tatatctttc cccccgaacc aagtatgaaa      720

attatagccg atatcttcga atataccgct aagcacatgc ctaagttcaa cagcattagc      780

atcagtggtt atcatatgca ggaagcaggc gcagacgcca tcttagaact ggcatacaca      840

ctggccgacg gactggagta ttcccggact ggcctccagg ctgggctgac tatcgatgag      900

ttcgcccccc gactctcttt tttctgggga attggaatga atttctatat ggagatcgcc      960

aagatgcggg ctggccgaag gctgtgggcc catctgatcg aaaaaatgtt ccagcccaag     1020

aactcaaagt cgctgctcct tcgggcccac tgccaaacct ccggttggtc cctgaccgag     1080

caggatccct acaacaatat cgtgcgaact gccattgagg ctatggccgc tgtgtttggt     1140

ggcacccagt ccctacatac aaacagcttt gacgaagctc tgggactccc aaccgtgaaa     1200

tctgccagga tcgcgagaaa cactcagatt attatccagg aggaaagtgg catccccaag     1260

gtggccgacc catggggcgg ctcatatatg atggaatgcc tgactaatga cgtgtatgac     1320

gctgccctga aactgatcaa cgagatcgag gagatgggag gcatggccaa agctgttgct     1380

gagggcatac caaagctgcg tatcgaagag tgcgctgcac ggagacaggc gagaattgac     1440

tccgggtccg aggtaattgt gggagttaat aagtaccagc tggagaagga agatgccgtc     1500

gaggttctgg caattgacaa tacatccgtg agaaaccgac agattgagaa gctgaaaaaa     1560

attaagtctt ccagagacca ggccctggcg gagcgctgtc tggctgcact cactgagtgc     1620

gccgcgtcgg gggatggcaa catcctggct ctcgccgtgg acgcatcgcg cgcccgctgc     1680

accgtcggcg aaatcacaga tgccttgaag aaggtgttcg gcgagcacaa agccaatgac     1740

agaatggtgt ctggggccta caggcaagag tttggagaat ccaaggaaat aacttcggca     1800

ataaagaggg ttcataaatt catggagcgg gagggtaggc gtcccagatt actggtggcc     1860

aagatgggac aggacgggca cgatagggga gcaaaggtga tcgctactgg gttcgccgac     1920

ttaggatttg acgtggacat aggcccctta ttccagacgc caagagaagt cgcacagcag     1980

gcggtagacg cagacgtgca cgcagtcggg gtgtccacac tggccgcggg gcacaagacc     2040

ctggttccgg agctcattaa ggaactgaat tctttgggca gacctgacat tcttgtgatg     2100

tgtggaggag tcatacctcc tcaggactac gaattccttt tcgaggtggg ggtgtctaat     2160

gtattcgggc ctggcacccg aattcccaag gccgcggtgc aggtactcga cgacatcgaa     2220

aaatgtctgg agaaaaaaca gcagtccgtg                                      2250


<210>  91
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  91
atgcttcgtg caaaaaacca actctttctg ttatcccccc actacctcag gcaggtgaaa       60

gagtcaagtg ggtcccggct aattcagcag cgtctgctgc atcagcaaca gcctcttcac      120

cctgagtggg cagctctcgc caagaagcag ctcaagggca agaatccaga ggatctgatc      180

tggcacactc ccgagggcat tagcatcaaa cccttgtatt caaagcgcga caccatggac      240

ttacccgagg agctgcctgg cgtgaaaccc ttcacgcggg gaccatatcc aactatgtat      300

actttcaggc cttggacaat tcgtcagtac gctggttttt ccacagtaga ggagagcaac      360

aagttctaca aagataacat aaaggccgga cagcaggggc tgtcggtcgc tttcgatctg      420

gctacccacc ggggctatga ttcggacaac ccaagggtta gaggtgatgt gggaatggcc      480

ggtgtcgcga tcgataccgt tgaagacacc aaaattctat tcgacggaat tcccctggag      540

aaaatgtctg tttctatgac tatgaatggc gcagtcattc ccgtccttgc caattttatc      600

gtcaccggag aagagcaagg ggtcccaaaa gaaaaactga ctggcaccat tcagaacgat      660

attctgaagg agtttatggt taggaatacc tacatctttc ctccagaacc aagcatgaag      720

ataatcgccg acatctttga gtacacagct aaacacatgc cgaaattcaa cagcatcagc      780

atcagcggat atcacatgca agaggcaggg gctgatgcta tcctcgaact ggcgtacact      840

ctcgctgatg ggctggagta cagcagaaca gggctgcagg cagggctgac tatcgacgaa      900

ttcgctcccc gcctgagctt cttctggggc attgggatga acttttatat ggagattgct      960

aaaatgcggg cgggaagacg gctatgggct catctgatcg agaaaatgtt tcagcctaag     1020

aactccaagt cgctcctgct gagggcccat tgccagacca gcggttggag cctgaccgag     1080

caggacccgt acaacaacat cgtgagaaca gccatcgagg ccatggctgc ggtctttggg     1140

ggtacccaga gtctccatac gaattctttt gacgaggccc tcggacttcc gacagtcaag     1200

agcgcccgga tcgctagaaa tactcaaatc atcatacagg aggaatctgg cattcccaaa     1260

gtcgcagacc cgtggggggg cagttacatg atggagtgtc tgacgaacga cgtgtatgat     1320

gccgcgttaa agctgatcaa tgagatcgag gagatggggg ggatggccaa ggcagtagcg     1380

gaaggcattc ccaaactccg aattgaggag tgcgccgcgc gacgccaggc ccgaatcgac     1440

tctggaagcg aggtgatcgt gggagtgaac aagtatcagc tggagaagga ggacgctgtg     1500

gaagttctcg caattgacaa cacttcggtg aggaatcgac agatcgagaa actgaagaag     1560

atcaaatcaa gtcgcgacca agcgctggcc gaaaggtgtc tggcggcctt gactgaatgc     1620

gccgccagcg gcgacggcaa tattcttgcg ctggcggttg atgcttcccg ggctagatgc     1680

accgtaggcg agattactga cgctcttaag aaggtatttg gtgaacataa agcgaatgat     1740

cgcatggtgt ctggcgcata ccgccaggaa ttcggagagt ccaaagagat aacttcagct     1800

attaaaaggg tccacaagtt catggaacgc gagggccgtc gcccccgcct gctggttgcg     1860

aagatgggcc aggacgggca cgacagaggc gctaaagtca ttgcaaccgg tttcgccgat     1920

ctgggctttg acgtggacat cgggcctctg ttccaaacgc ccagggaggt ggctcagcag     1980

gccgtggatg ctgatgtgca tgccgttggt gtgagtacat tggcagctgg ccacaaaacg     2040

ctcgtgcctg aactgattaa ggagctgaat tcgctggggc ggcctgatat tttggtgatg     2100

tgcggtggag taatccctcc tcaggactat gagttcctgt ttgaggtcgg ggtttcaaac     2160

gtgtttgggc cgggaaccag gatccccaaa gctgcagtcc aagtcctgga cgatatcgag     2220

aaatgcctgg aaaagaaaca gcaatccgtg                                      2250


<210>  92
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  92
atgctccggg caaaaaacca gctctttctg ctgagccctc attacctgag gcaagtgaag       60

gagtcaagtg ggagtcggct gatacagcag aggttactgc accaacaaca accactgcat      120

cctgaatggg cagcactggc aaagaagcag ctcaagggaa aaaaccccga agacttaatt      180

tggcacacac ctgaaggaat cagcattaag ccgttgtatt cgaagaggga tacaatggat      240

ctcccggagg aactgcccgg agttaagcca ttcacccggg gaccataccc tacaatgtat      300

actttccgcc cttggaccat ccgtcaatat gccggctttt ccactgtgga agagagcaat      360

aaattctaca aggataatat caaggccgga cagcaaggcc tatctgtggc gttcgacctg      420

gcaacccacc gtgggtacga tagtgacaac ccaagggtcc gtggggacgt ggggatggct      480

ggggtggcta ttgatacagt ggaagacaca aaaatcctct ttgacggaat acctctggaa      540

aagatgagtg tctccatgac aatgaacggc gccgtgatcc ccgtgctggc caacttcatc      600

gtgaccggag aggagcaagg ggtgcctaag gaaaagctca cagggaccat ccagaatgat      660

atcctcaaag aattcatggt gaggaataca tacatctttc cgcccgagcc aagcatgaag      720

attatcgctg acatcttcga gtatacggct aagcacatgc ctaaatttaa cagtattagt      780

atttctggct atcacatgca ggaagcaggg gctgatgcta tcctggagct ggcgtacaca      840

ctcgccgatg ggttggaata cagtaggacc ggactacagg ctgggttaac cattgatgag      900

ttcgcacctc gccttagctt cttctggggt ataggcatga atttttacat ggagatcgca      960

aagatgaggg cgggccgaag gctctgggcg catctcattg agaaaatgtt tcagccaaaa     1020

aactctaaga gtctactgct gcgggcccac tgtcagacaa gcggctggtc gttgaccgag     1080

caggacccct acaacaacat cgttcggaca gcgatcgaag ccatggcagc agtcttcgga     1140

gggacccagt ccttgcacac caattcattt gatgaggctc tcggtctgcc aactgttaaa     1200

agcgctagaa tcgcccggaa tacacagatt attatccaag aagagagcgg aatcccaaag     1260

gttgcggacc catggggggg cagttacatg atggagtgtc ttactaacga tgtgtacgac     1320

gcagccttaa aactgataaa tgagatcgaa gagatgggag gcatggccaa ggccgtggcc     1380

gagggaatac cgaagctaag aatagaggag tgtgctgcaa gaaggcaggc ccgaattgat     1440

tctggcagcg aggttattgt tggagttaat aaatatcagc tggaaaagga agacgctgtc     1500

gaagtgctgg caatagacaa cacctccgtg cgcaaccggc agatcgagaa actgaagaag     1560

atcaagtcat cccgggacca agccctggcg gaacgttgtc ttgcggcgct cacagaatgt     1620

gctgcgagtg gggatggaaa cattctggcc ctagccgtcg atgcaagccg cgctcgatgt     1680

accgtgggtg agattactga tgccttgaaa aaagtattcg gcgaacataa ggctaatgac     1740

agaatggtgt caggagccta ccgccaggaa tttggcgaga gcaaagaaat cacaagcgcc     1800

atcaagaggg tccataaatt tatggaacgc gaggggcgga gaccacgcct gctggtggcc     1860

aaaatggggc aagatggtca cgatcgggga gccaaagtta tcgctactgg attcgcagat     1920

ttaggctttg acgtggatat cggaccactc tttcagaccc cccgcgaggt cgcgcagcag     1980

gcagtcgatg ctgatgtcca tgccgtaggg gtgtccacct tagctgctgg ccacaaaact     2040

ctcgtgccag aactgatcaa agaactgaat agcttgggta gaccagatat tttggtgatg     2100

tgtggaggcg tgatcccacc acaggattat gagttccttt ttgaggtggg ggtgtctaac     2160

gtttttggtc caggaaccag aatcccaaag gctgctgtgc aggtgctgga tgatattgag     2220

aagtgcctcg aaaagaagca gcagtctgtc                                      2250


<210>  93
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  93
atgctgcgtg ccaaaaatca gctttttttg ctctccccac attacctgcg acaggtcaaa       60

gagtcctccg gtagccgact gattcaacag agattgcttc atcagcagca gccgttacat      120

cccgagtggg cagctctggc aaagaaacag ctgaagggca agaatcctga ggatctcatt      180

tggcacacgc cagagggaat ctcaattaag cccctgtata gcaagcgcga caccatggat      240

cttcctgagg agctgcctgg agtgaagcct tttactaggg gaccctaccc taccatgtat      300

acttttcggc cttggacaat tcgacagtac gcaggattct ccacagtcga ggaaagtaat      360

aaattttaca aagataacat caaagccggg cagcaggggc tgtctgtggc tttcgatctg      420

gccacccatc ggggatacga ttcagacaat cctcgggtcc gaggggatgt cggcatggcg      480

ggggtggcga tagacacagt ggaggatacg aaaattctgt tcgacggcat tcctctggag      540

aagatgtctg tcagcatgac catgaacggg gcagtaatcc ccgttttggc gaatttcata      600

gttactgggg aagaacaggg agtacccaaa gagaagctca caggtaccat ccaaaacgat      660

atattgaagg aattcatggt caggaatacg tacatcttcc ctccagaacc atcgatgaaa      720

ataatcgctg acatttttga atatactgcc aaacatatgc ccaagtttaa cagtattagc      780

ataagtggat accacatgca ggaagccggc gccgacgcca ttctcgagct tgcttacacc      840

ttggctgacg ggctggaata ctctcgtact gggttgcagg ctggcctcac tattgatgaa      900

tttgcacctc ggctttcctt cttctggggg ataggcatga acttttacat ggaaatcgcc      960

aaaatgagag ccgggagaag gctgtgggcc catctgattg agaagatgtt tcagcctaag     1020

aattcgaaga gtttactctt gcgggcccat tgccaaacga gtgggtggtc tcttacggaa     1080

caggatcctt ataacaatat cgtccggaca gccatcgagg ctatggccgc cgtttttggt     1140

ggcacccagt cccttcatac caattctttc gacgaagctc ttggattacc gaccgtgaaa     1200

tccgcccgga ttgcccgcaa tacccagatc atcattcagg aagaaagtgg gatccccaaa     1260

gtcgcagatc cttggggagg aagctacatg atggagtgcc tgacgaacga tgtctacgac     1320

gccgcactta agttgatcaa tgaaattgag gaaatgggag gcatggccaa agcggtggct     1380

gaggggatac ccaagttacg gatagaagag tgtgctgcca gaaggcaggc tcggatcgat     1440

agcggctcag aggtcattgt gggagtgaac aagtaccaat tggaaaaaga ggatgctgtg     1500

gaagtgctgg caattgataa tacctcagtc cggaatagac agattgagaa gcttaaaaaa     1560

atcaagtcta gccgagacca ggcgttagcc gagaggtgcc tcgcggctct caccgagtgt     1620

gccgcctcgg gtgacggcaa catcctggcc cttgccgtcg atgcctcccg ggctcgctgt     1680

accgtgggtg agattactga cgcactcaaa aaagtatttg gggaacataa agctaatgat     1740

cgcatggtct ccggtgcgta ccgtcaggaa ttcggcgaat caaaggagat tacatccgcg     1800

ataaaaaggg tccataaatt tatggaacga gaggggcgcc ggccgcgcct gctggtggca     1860

aaaatgggac aggatgggca tgatagaggc gccaaggtga tcgccacagg cttcgctgat     1920

cttggtttcg atgtagacat tggacccctc ttccagaccc ccagagaagt tgcccaacaa     1980

gccgtagatg ccgacgttca tgcggtaggc gttagcaccc tcgccgccgg ccacaagacg     2040

ctggtgccag agctgattaa agaattaaac tcactgggaa ggcctgatat actggtgatg     2100

tgtggcgggg tgatcccgcc ccaggattac gaattcctat ttgaggtggg ggtttccaat     2160

gtttttggcc cagggactcg aattcccaag gctgctgtac aggtgctaga cgatatagag     2220

aagtgcctgg agaagaagca gcagtctgtg                                      2250


<210>  94
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  94
atgttgagag ccaagaatca actctttctc ttatcacccc actacctgag acaagtgaaa       60

gagtcgtctg gcagtcgact gattcaacaa agattactcc accaacagca gcctctgcac      120

ccagagtggg ccgccctggc taagaaacag ctgaagggga aaaaccctga ggacctgata      180

tggcacacac ctgaaggcat ctccattaaa ccattgtata gtaaaagaga taccatggat      240

ctgcctgagg agcttcctgg ggtgaaaccg tttactaggg gtccataccc caccatgtat      300

acttttcgcc cttggacaat caggcagtac gcgggatttt caacagtgga ggagagtaat      360

aagttttata aggataatat caaagcggga cagcagggtc tcagcgtagc tttcgacctg      420

gccacacatc gtggatacga ttccgataac ccaagggtgc ggggggatgt ggggatggct      480

ggtgtggcca tcgacaccgt tgaagatact aagatcttgt ttgatggaat tccccttgaa      540

aagatgtcag tcagcatgac aatgaatggg gccgtcatcc cagtgctggc caatttcata      600

gtgacagggg aagagcaggg agtcccaaag gagaaactca cagggaccat ccagaacgac      660

atcctcaagg aatttatggt ccggaataca tacattttcc ctccggaacc ctcaatgaag      720

atcatcgctg acatcttcga gtacaccgct aaacatatgc ctaaattcaa ttctatctca      780

atcagcggat atcacatgca ggaggcagga gccgacgcta ttctagaact cgcgtacact      840

ctggcagatg gtctcgaata ctcccggacc gggctccaag ctgggttgac cattgacgaa      900

tttgcgcctc ggctgagctt tttttggggg attggcatga atttctacat ggagattgca      960

aaaatgcgtg ccgggcgaag attatgggct catctgatag aaaaaatgtt tcagccaaag     1020

aatagcaaga gtcttctgct gagagcacat tgtcagacat caggatggtc cctgacagag     1080

caggatcctt ataataatat cgtgcggaca gcaattgagg caatggctgc tgtatttggt     1140

gggacccaaa gtttacacac aaatagcttc gatgaggctc tcgggcttcc caccgtcaag     1200

tctgctcgga tcgctagaaa cacgcagatt atcatccaag aagaaagcgg aatccccaaa     1260

gtggcagacc cttggggtgg gtcatacatg atggaatgtc tgactaacga tgtctacgat     1320

gctgcactga agctgattaa tgagatagag gagatggggg gaatggccaa agccgtggct     1380

gagggcatcc ctaagttgcg gatcgaagaa tgtgccgcac gtagacaagc caggatagat     1440

agtggtagcg aggttatcgt cggagtgaat aagtaccagc tagagaaaga ggacgccgtg     1500

gaggtgttgg caattgataa cacctccgtt agaaacaggc agatcgagaa actaaaaaag     1560

attaaatcat cgagagacca agctttggcc gaaaggtgtc tggctgcgct cacagaatgc     1620

gccgcttcag gcgatggcaa catcctggca ctggctgttg atgcgtccag ggctcgctgt     1680

accgttggcg aaatcacaga tgctctcaag aaggtctttg gtgagcacaa agcaaacgac     1740

cggatggtct ccggagctta ccggcaggaa tttggagaaa gcaaggagat tacctcagct     1800

atcaaaaggg tgcataagtt catggagcgt gaagggcgcc ggcccaggct tctggtggct     1860

aaaatgggcc aggacggcca tgaccgagga gccaaggtca tcgccacagg gttcgccgat     1920

ctaggctttg atgtggatat cgggccctta ttccagactc ctcgcgaggt agcacagcag     1980

gccgtcgatg ccgatgtgca cgcagtgggc gtatctacac tcgcggctgg gcataagacg     2040

ctagtacctg agctgatcaa ggagctgaac tccctgggca ggcccgatat tctggtgatg     2100

tgtggcgggg tgataccccc tcaggattat gaattcttat ttgaagtggg cgtcagtaat     2160

gtttttgggc ctggtactcg gatcccaaag gcggcagtgc aagtcttaga tgacattgaa     2220

aaatgtctcg agaaaaagca gcagagcgtc                                      2250


<210>  95
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  95
atgctgcgag caaagaatca gctgttcctc ctgtccccac actatctacg ccaagtgaag       60

gagtcgagcg gatctaggct aatccaacaa agactgctgc atcagcagca accactgcac      120

ccggaatggg ctgcgctcgc taagaaacag ctgaaaggta aaaacccaga ggatcttatc      180

tggcacactc ccgaaggtat cagcattaaa cctctttaca gtaagcgcga tactatggac      240

ctccccgaag aactaccagg cgtgaaaccg tttactcgag gcccataccc caccatgtac      300

acatttaggc cttggacaat acgacagtac gccggattct caaccgtgga agaaagcaac      360

aaattctaca aagataatat caaggcgggc cagcagggat tgagtgtagc cttcgacctg      420

gcgacccaca gagggtatga ctccgacaac ccccgggtgc ggggcgacgt cggaatggca      480

ggggtcgcga ttgataccgt tgaagatacg aagatcttat ttgacgggat tccactagaa      540

aagatgtcag ttagtatgac aatgaatgga gccgtgattc ccgtgctggc caactttatc      600

gtgaccggag aagagcaggg agtgccaaag gaaaagctga caggaacaat ccagaacgat      660

atattaaagg aatttatggt gagaaacaca tatatatttc cacctgaacc ctctatgaaa      720

ataatagcgg atatattcga atataccgcc aaacatatgc ccaagttcaa ctccatttcc      780

atcagtgggt accacatgca ggaggccggt gccgatgcaa ttctcgagct cgcatatact      840

ctggctgatg ggttggagta ttcacggact ggattgcagg caggactaac tattgatgag      900

ttcgcaccca gactatcctt tttttgggga atagggatga atttctacat ggaaattgcg      960

aaaatgcggg ccgggcggcg gctatgggcg cacctgatcg agaagatgtt tcaacccaag     1020

aacagtaagt ccctgctcct cagagcacac tgccagacat caggctggtc tcttaccgag     1080

caggaccctt ataataacat agttcgtaca gccattgaag ctatggctgc agtatttggc     1140

gggacccaga gtctgcatac taattcattc gatgaagcac tggggttacc taccgtgaaa     1200

agcgctcgaa tcgcaaggaa cactcagatc attatccagg aagagagtgg catccctaaa     1260

gtggccgatc cctggggcgg ctcatatatg atggagtgcc tgactaatga tgtgtacgac     1320

gctgctttga aactgataaa tgagatcgag gagatgggcg gcatggccaa agccgtggcc     1380

gaagggatcc ctaagttacg gatcgaggag tgtgccgctc ggcgacaggc tcggatcgac     1440

tctggctccg aggtcattgt cggcgtaaac aagtatcagc tggaaaagga ggatgccgtg     1500

gaggtgctcg caatcgataa cactagtgtg aggaatagac agattgaaaa actgaaaaaa     1560

attaagagca gccgagacca agcccttgct gaaagatgcc tcgccgcact caccgaatgc     1620

gcagcctcag gcgatggcaa tattcttgcc ttggcagtgg acgcatcaag ggcacgctgc     1680

accgttggag aaatcaccga cgcacttaaa aaagtgttcg gtgaacataa ggccaatgac     1740

cggatggtca gcggcgccta taggcaggag tttggagaga gtaaagaaat tacttccgcc     1800

atcaagcgcg tccacaaatt catggagcgg gagggccggc gccccaggct gctggtggca     1860

aaaatgggac aggatgggca cgatcgggga gccaaagtga tagcaactgg gtttgcagat     1920

ctcggcttcg acgtggatat cgggcccttg ttccagacgc ctagggaggt ggctcagcag     1980

gctgttgacg cagatgtcca cgctgtgggc gtctcaactc tggctgccgg ccataaaacc     2040

cttgtgcctg agctgatcaa ggagctgaat agtctgggta ggccggatat cctggtcatg     2100

tgtggggggg tcatccctcc ccaggattat gaatttctct tcgaggtcgg cgtatctaac     2160

gtcttcggcc caggaacgag gatccccaag gcggccgtgc aggtacttga cgatattgag     2220

aaatgtcttg aaaagaaaca gcagagtgtg                                      2250


<210>  96
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  96
atgctgcgtg ccaaaaacca actgtttctc ctatcgcctc actatctccg ccaggttaag       60

gaatcttcgg gctcccggct aatacagcag agactgctac atcagcagca acctctacat      120

ccagagtggg cagcgctggc gaagaagcag ctgaagggaa agaacccaga ggatcttatc      180

tggcataccc ccgaggggat atctattaaa ccactgtaca gcaaacgaga caccatggat      240

ctgccagaag agcttccggg ggtgaaacca ttcacacggg gaccatatcc aacaatgtac      300

acgttccggc catggaccat ccgacagtac gccggctttt caactgtgga ggaatccaac      360

aagttttaca aggataatat taaggcagga cagcaggggc tgtctgtcgc tttcgacctc      420

gccacccacc gcggttacga tagcgacaac ccccgcgtca ggggggatgt cggcatggct      480

ggcgtggcca tcgacaccgt cgaagacacc aagatcctgt tcgatggaat cccgctggaa      540

aaaatgtcag taagcatgac catgaatggc gccgtaatcc ctgtactggc aaactttatt      600

gtgacaggcg aagagcaggg agtccctaag gagaagctga cagggaccat acagaatgat      660

attcttaaag agttcatggt gagaaacact tatatttttc ctccagagcc ttcaatgaaa      720

ataatagccg atatctttga gtacaccgcc aaacatatgc ccaagtttaa tagcatttct      780

atatccggtt accatatgca ggaagcaggt gcagacgcta ttctggaatt ggcctacacc      840

ctggctgatg gacttgaata cagccgcacc ggactccagg ccgggcttac aattgacgag      900

ttcgccccac gcttgtcctt tttttggggt attggcatga acttctacat ggagatagcc      960

aagatgcgtg ccggtcggag gctgtgggca cacttgattg agaaaatgtt ccagcctaag     1020

aattctaagt ctctgcttct gagggcccac tgtcagacta gtggttggtc actgaccgaa     1080

caggatccgt ataataacat tgtgcgcacg gccattgaag ccatggcggc cgtttttggc     1140

ggcacacaga gcctccacac caatagcttc gacgaggctc tgggtctgcc tacagtgaaa     1200

tcggcccgga tcgctagaaa cacacagatc attattcagg aagaaagcgg cataccaaaa     1260

gtggccgacc cttggggcgg ctcttatatg atggaatgtc tgactaatga tgtttatgat     1320

gccgccttaa aactcattaa tgaaatcgaa gaaatggggg gcatggctaa ggcggtggcc     1380

gagggcatac caaaactgag gatagaagag tgcgccgccc ggcgacaggc caggattgat     1440

agtggttctg aggttatcgt tggcgtaaac aaatatcagc tagagaaaga ggacgccgtg     1500

gaagtcctgg ccatcgacaa cacgagcgta cggaacaggc agattgagaa gctgaaaaag     1560

ataaagagca gtcgcgacca ggcactggcg gagcgatgcc tggccgcact gaccgagtgc     1620

gctgcaagtg gcgatggcaa tatcctggct ctcgcagttg atgcctccag ggccagatgc     1680

accgtgggag agatcacaga tgcccttaaa aaggtatttg gagagcataa ggccaacgac     1740

cgcatggtct ctggggcgta cagacaagag tttggagagt ctaaagagat tacatccgcc     1800

attaagagag tacacaagtt tatggagcgc gaaggaaggc gtccccgcct gctggtagcc     1860

aagatgggcc aagacggcca tgatagaggc gctaaggtta tcgccactgg cttcgcagat     1920

ttaggatttg acgtcgacat cggacccttg tttcagaccc ccagagaggt cgctcagcaa     1980

gctgtggatg ctgacgtcca tgcagtgggg gtctcaacgc tggcagcggg acataaaact     2040

ctcgtgcctg agttgatcaa ggaactcaat tccctggggc gccctgatat ccttgttatg     2100

tgtggtggag tcattcctcc ccaagattat gaatttctat tcgaagtggg cgtctctaat     2160

gtctttggcc ctgggacaag gattccaaag gcagctgtgc aggtgttaga cgatatagaa     2220

aaatgtctcg aaaagaaaca gcaatccgtg                                      2250


<210>  97
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  97
atgttgaggg ccaagaacca gttgttcctc ctgtctccac actacctgcg acaggtcaag       60

gagagcagcg gaagccgact cattcagcaa agactcctcc accagcagca gcccctgcac      120

cccgagtggg ccgcactggc taagaaacag ctgaaaggaa agaacccaga ggatctcata      180

tggcatacgc ctgaggggat cagcattaag cccctttaca gcaagagaga tactatggac      240

cttcccgaag agcttcccgg ggtgaaacca ttcacacggg gtccctatcc gaccatgtac      300

acgttccgtc cctggactat ccggcagtat gctggatttt ctaccgtgga ggagtccaac      360

aagttttata aggataatat caaagccggg cagcagggcc tttccgttgc ttttgacctg      420

gccacccatc gcggctacga ttcagataac cctcgcgtaa ggggtgatgt gggaatggcc      480

ggtgtagcaa ttgacacggt ggaagacaca aaaatcctgt tcgacggtat ccctcttgag      540

aaaatgtccg tctcaatgac catgaacggc gctgtgattc ccgtactcgc caacttcatt      600

gtgacaggcg aggaacaggg cgtccccaaa gagaagctaa ccggaaccat tcaaaacgac      660

atcttaaagg agttcatggt ccgcaacacc tacatattcc cacctgaacc ctccatgaag      720

atcattgcag atatttttga atacaccgcg aagcacatgc ctaaatttaa ctctattagc      780

atctccgggt accacatgca agaagcgggg gctgacgcca ttctggagct cgcttacact      840

ttggcggatg gactggaata cagcagaacg gggctccaag ctgggctgac tattgacgag      900

tttgcacccc gcctcagctt cttttggggc atcgggatga atttctatat ggaaattgct      960

aagatgcggg ctggccgtag actctgggca cacctcatcg agaaaatgtt tcaaccaaag     1020

aactctaaga gtctactgct cagggctcac tgtcagacct ccggctggag tctcacagag     1080

caggaccctt ataataacat tgtcaggaca gcaatagagg ctatggctgc cgtcttcggc     1140

ggtacccaga gcttgcacac caacagcttc gatgaagcac tcggcctgcc aacagtgaag     1200

tcggcgcgga tcgctagaaa cacccagatc ataattcagg aggagagtgg tattccgaag     1260

gtcgcagatc catggggggg gtcctatatg atggagtgcc taacaaatga tgtatacgac     1320

gcagctttga agctgatcaa cgagattgaa gaaatgggag gcatggccaa agcggtggcg     1380

gaggggattc caaagcttcg gattgaagag tgcgccgccc gccggcaggc ccgaattgac     1440

tcaggctcag aagtcattgt tggcgtcaat aaataccagc tggaaaagga ggacgccgta     1500

gaagtgctcg ctattgataa tacatccgtg agaaacagac agattgagaa gctgaagaaa     1560

ataaagagct ctcgcgatca ggctttagcc gaaaggtgtc tggctgcact taccgagtgt     1620

gcagcgtccg gagacggtaa cattctggcc ctagcagtgg atgctagcag agcccgctgc     1680

acagtgggcg agatcacaga tgctttaaaa aaggtgtttg gagaacataa ggcaaatgac     1740

cgcatggtct cgggagctta tcgccaggaa ttcggcgagt ctaaagagat tacaagtgct     1800

attaaaagag tgcataagtt tatggagcgg gagggtagga ggcctcgatt attggttgcc     1860

aagatggggc aggatgggca tgaccgggga gcgaaagtca ttgcaactgg ctttgctgat     1920

ctgggatttg atgttgacat aggaccgctg ttccaaactc cacgcgaagt agcccagcag     1980

gctgtagatg cggacgtgca cgccgtgggg gtttccaccc tggctgcagg acataagaca     2040

ctggtgcctg aacttattaa ggagctgaac tccttaggga ggcccgatat ccttgttatg     2100

tgtggcggtg tgatcccccc acaggactat gaatttctgt ttgaagtagg cgtgtcaaac     2160

gtcttcggcc ccggcacacg gatcccgaag gctgccgttc aagtcttgga cgacatcgaa     2220

aagtgcctcg aaaagaagca acagtctgtc                                      2250


<210>  98
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  98
atgcttagag ccaagaacca gctgtttctc ttgtctcctc attatcttag acaggtcaaa       60

gagagtagcg ggtcgaggct tatacagcag cggcttctac atcagcagca gcctctgcac      120

cccgagtggg cggcactagc aaagaagcaa ctcaaaggca aaaatccaga ggaccttatt      180

tggcacacgc ctgaggggat atcgatcaag ccgctttaca gcaagcgcga cacaatggac      240

ctcccagaag agctccctgg cgtgaaacca ttcacccgcg ggccctaccc tacgatgtat      300

acgttccgcc cctggaccat aagacagtat gccggtttta gcactgtcga agagtctaat      360

aagttctaca aagataatat taaagctggg cagcagggac tgtccgtcgc ttttgacctg      420

gcgacccatc gtgggtacga tagcgacaat ccgcgcgtcc ggggcgatgt tgggatggca      480

ggcgtcgcaa tcgatactgt ggaggacacc aagatcctgt ttgacggcat ccccctggag      540

aagatgtcag tgagcatgac aatgaacggt gctgtcatcc ccgtgctcgc aaactttatc      600

gtcacgggag aagagcaggg tgtgccgaag gagaagttaa cagggaccat tcagaacgat      660

atcctgaagg agtttatggt caggaacacc tatatttttc cacccgagcc atctatgaag      720

attatcgccg acatatttga atatactgca aagcatatgc ctaaattcaa tagtatttca      780

atctcgggct atcatatgca agaggccggg gccgatgcaa tactggagct tgcttatacg      840

ttagctgacg ggcttgagta tagtaggacg gggcttcaag ctggactgac cattgatgaa      900

ttcgctccca ggctgtcctt cttttggggg atcggtatga atttctacat ggagatcgcc      960

aagatgcgag ctggccgcag actatgggca cacctcatcg agaaaatgtt tcaaccaaaa     1020

aactccaaat cccttctcct acgggcgcat tgccagacca gcggatggag cctcactgag     1080

caggatccat ataataatat agtgaggacc gctattgagg ctatggctgc cgtgtttggc     1140

ggaacccaga gcctgcacac caactccttc gatgaagccc tggggctccc cacggttaaa     1200

agcgcgagaa tcgctcggaa cacacagatt attatacagg aagaatctgg tatccctaag     1260

gtggctgatc cttggggcgg atcctatatg atggaatgct tgacaaatga cgtgtatgat     1320

gccgccctga agcttatcaa cgaaattgaa gagatgggcg gcatggccaa ggcagtagcc     1380

gaaggcatcc ctaaactgcg gatagaagag tgcgctgcac gccgtcaagc tagaatcgac     1440

agtggcagtg aggttatcgt cggcgtcaac aagtatcagc tggaaaagga ggatgccgtt     1500

gaggtattgg cgatagacaa taccagcgtc cgtaacaggc agattgaaaa actgaaaaag     1560

atcaagagct cacgcgatca ggctctagcc gaaagatgct tagccgccct gacggagtgt     1620

gctgcaagcg gcgacggcaa catcttggcc ctggccgtag atgccagcag agctcgctgc     1680

accgtgggtg agatcactga tgccttgaaa aaggttttcg gggaacataa ggccaatgac     1740

cgcatggtgt ccggcgcata ccgacaggaa tttggagaga gtaaagagat tacttcagcc     1800

ataaaacgtg ttcacaagtt tatggaaaga gagggtagga gaccgcggct gctagttgca     1860

aaaatgggcc aggatggcca cgacaggggt gctaaggtga tcgcgaccgg atttgcagac     1920

ttgggcttcg atgtggatat tggcccgctg ttccaaactc cgcgagaagt ggcccagcaa     1980

gcagtcgatg ccgacgttca tgcagtcggc gtcagtactc tggccgccgg gcacaagact     2040

ttagttcccg aacttatcaa ggagctcaat agtttgggga gaccagacat cctggtgatg     2100

tgcggaggag ttatccctcc acaagactat gaattcctgt ttgaagtggg cgtgtccaac     2160

gtcttcggcc ccggaacacg aatacccaag gcggcagttc aggttcttga tgatatcgag     2220

aagtgtttgg agaaaaaaca gcagtccgtg                                      2250


<210>  99
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  99
atgctgagag ccaaaaatca gttgttcttg ttaagtccac attacctgag gcaggtcaaa       60

gagtcaagcg gcagcaggct catccaacag agactgttgc atcaacagca gcctctccac      120

cccgaatggg ccgcacttgc caagaaacag ttgaaaggca agaaccccga ggaccttatc      180

tggcatacac cagagggaat cagcatcaaa cccctataca gcaaaaggga cactatggac      240

cttccagagg agctcccagg cgtcaaaccc tttacacgtg gtccctatcc tacgatgtac      300

accttcagac cttggaccat ccgccagtac gccggcttta gtacggtaga agagagcaac      360

aagttttaca aagataacat aaaagctggg cagcaaggac tgtccgtggc cttcgaccta      420

gcgactcacc ggggctacga ctccgacaat ccaagggtcc gtggcgatgt agggatggcc      480

ggggtggcaa tcgatactgt agaagataca aaaattttgt ttgacggcat ccccctggag      540

aagatgtcag tttccatgac tatgaatggg gccgtgatcc ccgtgttggc gaatttcata      600

gtgacagggg aagaacaggg agtacccaag gagaagctca cggggacgat ccagaacgac      660

atcttgaaag aatttatggt gcgcaatact tacatcttcc ccccggaacc ttctatgaag      720

atcattgccg acattttcga gtatacagct aagcacatgc caaaatttaa ttcaatctct      780

atttcaggat accatatgca ggaggccggc gccgatgcca tcttggagct agcctatacc      840

ctcgctgatg gactggaata ctcaaggact gggttgcagg cgggactaac aatcgacgaa      900

ttcgccccac gtcttagctt tttttggggg attggaatga acttctatat ggaaatagca      960

aaaatgagag cgggcagaag actctgggcg catctcatcg aaaaaatgtt ccaacccaag     1020

aattccaaga gcctcctgct gagagctcat tgccagacat ctggctggtc gttaaccgaa     1080

caagacccct ataacaacat cgttcgcact gccatcgagg ccatggcggc ggtattcggt     1140

ggaacacagt cgctgcacac aaacagtttc gatgaggccc ttggcctccc aactgttaag     1200

tctgcgagaa ttgcccggaa cacgcagatt ataatacagg aagagtctgg cattccaaag     1260

gtcgcagacc cctggggggg atcctacatg atggaatgtc tgacaaatga cgtttatgat     1320

gcggccctta agttgataaa cgagatcgaa gaaatgggag gcatggctaa agccgttgca     1380

gaaggcattc ccaagctgcg catcgaggag tgcgccgcta ggaggcaggc taggatagac     1440

tcaggcagcg aagtcattgt aggcgtgaat aagtatcagc tcgagaagga ggatgcggtg     1500

gaagtgcttg cgatcgacaa tacctctgtt cgcaaccggc aaatagaaaa acttaagaaa     1560

atcaagtcct cccgcgatca ggctttagcc gaacggtgcc tggccgcttt aacggagtgc     1620

gccgcttcgg gggacggtaa tattctggct ctcgccgtag acgcctccag agccagatgc     1680

acggtgggtg aaataacgga cgctctgaag aaggtgtttg gggaacacaa agcgaacgac     1740

cgcatggtgt caggtgctta ccgacaggaa tttggtgaga gtaaagagat caccagcgcc     1800

attaaacggg tgcataagtt tatggagcga gaaggccgta gacctaggct actggtggct     1860

aagatgggac aggatggcca tgaccgcggg gcaaaggtca tcgccaccgg ctttgctgac     1920

cttgggttcg acgtcgacat tggtcccttg ttccagaccc ctcgggaagt ggcccagcaa     1980

gccgtggacg ctgacgtgca cgctgtgggc gtgtcaacac tggccgccgg acacaaaact     2040

cttgtccccg aactgatcaa ggagctgaac tcattggggc ggcccgatat tttggtgatg     2100

tgtggaggag tcatcccacc tcaagactac gagttcctat tcgaagtggg cgtctctaac     2160

gtctttgggc ctggtactcg catcccgaaa gcggccgtgc aagttttaga cgacatagaa     2220

aaatgcctgg agaaaaagca gcagtccgtt                                      2250


<210>  100
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  100
atgttgcggg ctaagaacca acttttcctt ctctctcccc actacctgag acaggtgaag       60

gaatcaagcg gctcccgact gatccagcag cgactgctgc atcaacagca acccctacat      120

ccggaatggg ccgcgctcgc taagaaacaa ctgaagggca aaaatcccga agatttgatc      180

tggcataccc cagagggcat ttcaattaaa cctctctata gtaagagaga cactatggac      240

ctgccggagg agttgcctgg ggtcaagcca tttacccggg ggccataccc cacgatgtat      300

actttccgcc catggacgat ccggcagtat gctggttttt caacggtgga agagtcgaac      360

aagttttata aagataatat caaggccggc caacaggggt taagtgtcgc ctttgatctg      420

gccacgcacc gtggatacga cagcgataat cctcgcgtga gaggcgatgt ggggatggca      480

ggggtcgcca ttgacaccgt cgaagacact aagatcctct tcgatgggat ccccttagag      540

aagatgagtg ttagtatgac aatgaatgga gcagttatac ctgttttggc caatttcatc      600

gtaaccggcg aggagcaagg ggttcctaag gagaagctca caggtactat ccagaacgat      660

atcctgaagg agttcatggt tcgcaatacc tatatctttc ctccagagcc cagcatgaaa      720

atcatcgcag atattttcga gtatactgct aaacatatgc caaagtttaa ttcaattagc      780

attagcggat atcacatgca agaagcaggg gccgatgcaa tcctggagct ggcgtatacg      840

cttgccgacg gcttagaata ctcacggaca ggactgcaag caggactgac tattgatgag      900

ttcgcccctc ggctgtcctt cttttggggg attgggatga atttctatat ggaaattgca      960

aagatgcgcg cgggccgacg actgtgggcc catctaatcg aaaagatgtt tcagcctaag     1020

aactccaagt ctttactgct gcgtgctcac tgccagacta gtgggtggtc attgacagag     1080

caggacccat ataacaatat agtgaggacc gcaatcgagg ctatggctgc cgtcttcgga     1140

ggaacgcaga gcctccatac taacagcttt gatgaggccc tgggccttcc cactgtaaag     1200

agcgcccgca tcgcaagaaa cactcagatc attatccagg aagaatctgg aatccccaaa     1260

gtcgcagacc cctggggcgg ctcctatatg atggagtgct tgactaacga cgtgtacgat     1320

gccgccctca agctgattaa tgaaatcgaa gagatgggcg ggatggccaa agcggttgct     1380

gagggtatcc ccaaactgcg aatcgaagag tgcgctgcac gccgccaggc tcgtatagat     1440

tccgggagcg aggtaattgt tggggtaaac aaataccagc tggagaagga agacgctgtt     1500

gaagttctag ctattgacaa cacatccgtc cggaatcggc agatcgagaa acttaagaag     1560

attaagagta gtcgcgatca ggccctcgcg gaaagatgtc tggccgccct gaccgagtgc     1620

gccgcaagcg gtgatggcaa tatactggcc ctcgctgtgg atgccagccg agcccggtgc     1680

accgtgggcg agattactga cgccctgaag aaagtgttcg gggaacacaa ggccaacgat     1740

aggatggtga gtggcgccta tcggcaggag ttcggagagt ctaaagaaat cacaagtgcc     1800

atcaaacgcg tgcacaaatt catggaaaga gaaggtcggc gcccgcgttt gctggtggca     1860

aagatgggtc aggatggtca tgaccggggc gctaaggtca ttgccaccgg cttcgctgac     1920

ctaggattcg acgtggacat cgggcccctg ttccagaccc ctcgggaggt ggctcaacaa     1980

gccgtggacg ccgatgtaca cgctgtgggt gtttctaccc tcgcggctgg gcataaaaca     2040

ttggtgccag aactgattaa ggaactgaat agtctgggcc gcccggatat tttagtcatg     2100

tgtggtggag tgatcccccc gcaggactac gagttcctat ttgaggtggg agtgagcaat     2160

gttttcggcc ctggcactag gattcctaaa gccgccgtgc aggtgttaga tgacattgag     2220

aaatgcctcg agaaaaagca acagtctgtg                                      2250


<210>  101
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       WT mutation

<400>  101
atgctccgcg ctaaaaatca gctgtttcta ctgtctccgc attaccttcg gcaagtcaaa       60

gaatcctctg gcagccgact cattcaacag cgcctgctgc accagcagca gcctctccat      120

cccgagtggg ctgctctggc caagaagcag ctcaagggga aaaatcctga ggatctgatc      180

tggcataccc ccgaagggat cagcatcaag cctctgtact ctaagcggga taccatggat      240

ctgccggaag agttacctgg cgtgaagcct ttcaccaggg ggccttatcc gacaatgtat      300

accttcagac cttggaccat tcggcagtac gctggattca gcaccgttga agaatctaat      360

aagttttata aagataatat taaagcggga caacaggggc tgtcagtggc cttcgatctc      420

gctacccacc gtggttacga cagtgataac cctcgagtta gaggtgacgt gggcatggcg      480

ggcgtagcca tagacaccgt agaagacacc aagattctgt tcgatggcat ccctctggaa      540

aagatgagcg tctctatgac catgaatggg gccgtcattc cagtgcttgc caactttatt      600

gtcacgggcg aggagcaggg ggtccccaaa gaaaaactga ccgggactat ccagaacgat      660

attctgaagg aattcatggt tcggaatacc tacatcttcc caccagagcc aagtatgaaa      720

ataatcgcag atatcttcga gtataccgct aagcacatgc ccaagttcaa ctctatttct      780

atttcaggct accatatgca ggaggccggc gccgacgcaa tccttgaatt agcctataca      840

ctagctgatg gactcgagta tagtcgtacg ggtttgcagg ccgggctaac cattgacgag      900

ttcgcccctc gactttcctt cttctgggga ataggaatga acttctatat ggaaatcgcc      960

aagatgcgag ccggaagacg actgtgggct caccttatcg aaaagatgtt ccagcccaaa     1020

aacagcaagt ccctgcttct gcgcgctcac tgccagacga gtggctggag tcttacagaa     1080

caggatccat ataacaacat tgtgcggact gcgatcgaag ccatggccgc cgtattcgga     1140

gggactcagt cattgcacac aaacagcttt gacgaggccc tgggcttgcc cacagtgaaa     1200

agcgctagga ttgccagaaa cacgcagatc atcatccaag aagagagtgg catacctaag     1260

gtggccgacc cctggggggg atcctatatg atggaatgcc tgacaaacga tgtgtacgat     1320

gccgctctta agctgattaa cgagattgaa gagatgggcg ggatggcaaa agccgtggcc     1380

gaggggatcc ccaagttgcg gatcgaggag tgtgcagctc gaagacaggc tcgaattgat     1440

agcggcagcg aagtgatagt gggcgtaaat aaataccaac ttgagaagga ggatgcggtg     1500

gaagtgctag ccatcgataa caccagcgtg cggaaccgac agattgaaaa actgaagaag     1560

attaaatctt cacgggacca ggctctagcc gagcgttgtc tcgcggcgct gaccgagtgc     1620

gcagcgtctg gagatggcaa tattctcgcg ctcgctgtgg acgcgagtcg ggcgcggtgt     1680

accgtgggcg agatcacgga tgctctcaaa aaggtttttg gcgagcacaa agccaatgat     1740

agaatggtga gcggggctta caggcaagaa ttcggggaat caaaagagat cacctccgcc     1800

attaaaaggg tccacaagtt tatggaacgg gagggaaggc gccccagact gttagtcgca     1860

aagatgggtc aggatgggca cgatcgcggt gcaaaagtga ttgccaccgg cttcgccgat     1920

ctgggcttcg acgttgatat cgggcctctg ttccagaccc caagagaagt ggcacaacag     1980

gcggtagatg ctgacgtcca cgccgtcggg atatctactc tggccgcagg gcacaaaaca     2040

ttagttccgg agctcatcaa agaactgaat tcgctcggac ggccggacat tctcgtgatg     2100

tgtggggggg tgatccctcc ccaggactac gagttcctct tcgaggtggg agtgagcaac     2160

gtcttcgggc caggtacacg tatacccaaa gcagctgttc aggtgctaga tgacatcgag     2220

aagtgcttag aaaaaaagca acagtcagtc                                      2250


<210>  102
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       WT mutation

<400>  102
atgctgagag caaaaaacca actcttcctt ctgtctccac actatctccg gcaggtgaag       60

gagtccagtg gctccagact gattcagcag cgacttctgc accagcagca gccacttcat      120

cccgagtggg ccgccttggc aaaaaaacaa ctgaaaggta agaacccgga agatttaatt      180

tggcatacac cggaaggaat ttctatcaaa cccctgtact ctaagaggga cacaatggat      240

ctgccagagg agctgcctgg ggtcaagccc ttcacgagag gcccctaccc caccatgtat      300

acgttccggc cttggacaat caggcaatac gccgggtttt caacagtgga agagtcgaac      360

aagttttaca aagacaatat taaggccgga cagcagggcc tttccgtagc attcgatctg      420

gcaacacacc gcgggtacga tagtgataac ccccgggtta ggggcgatgt aggtatggcc      480

ggggtagcta ttgacaccgt tgaagacacc aagatccttt ttgatggcat cccactcgag      540

aagatgtctg tgagcatgac aatgaatggg gcggtgatac cggtcctggc aaacttcatt      600

gttactggtg aggagcaggg cgtgcccaag gaaaagttaa ccggaaccat acagaatgat      660

atcctcaaag agtttatggt tagaaatacc tacattttcc cacccgagcc ttctatgaaa      720

atcatagccg acatctttga gtataccgct aagcacatgc caaagttcaa ctctatttcc      780

atctcaggat atcatatgca ggaagccggc gccgatgcga tcctagaact cgcctacaca      840

ctggcggatg gactcgaata ttctcggacc ggcctgcagg ccggcttaac cattgacgag      900

ttcgccccca ggctgagctt tttttggggc atcggaatga acttttatat ggagatcgca      960

aagatgcggg ccggcagacg cctgtgggcc cacctcatag agaagatgtt ccagcctaaa     1020

aatagcaagt cattactcct cagggcacat tgccagacta gcggatggtc attgactgaa     1080

caggatcctt ataataatat cgtacgtacg gcaatcgagg cgatggccgc ggtgtttggg     1140

gggacccaat ccctgcacac taattccttc gacgaagccc tggggcttcc taccgtcaag     1200

tcggcaagaa tcgccaggaa cacccagatt ataattcagg aagaatccgg tattcccaag     1260

gtcgcagacc cgtggggggg ctcttacatg atggaatgtt taaccaatga cgtgtacgat     1320

gccgccctaa agctgatcaa cgaaattgag gaaatggggg gcatggcgaa agccgttgca     1380

gagggcatcc caaaattaag aatcgaggaa tgcgcggctc gccgccaggc gcgcatcgat     1440

agtggctccg aggtgatcgt aggggttaat aagtatcagc tggaaaaaga ggatgcagtg     1500

gaggttcttg ctatcgataa tacttccgtg aggaaccggc agatcgaaaa gctgaagaag     1560

atcaagtcca gccgtgatca ggctctggcc gaacgctgct tggccgcact gacagagtgc     1620

gccgcctctg gcgacggcaa tatcctagcc ctggctgtgg atgcgtcacg ggcccgatgt     1680

acagtcggtg agataacaga tgctcttaag aaggtcttcg gcgagcataa ggctaacgac     1740

cggatggtgt caggtgcgta ccggcaagaa tttggggaga gtaaggaaat cacctcagca     1800

ataaagcggg tccataagtt catggaacgg gaaggacgcc gcccccggct tttagtggca     1860

aagatgggcc aggatggtca cgaccgcggc gcaaaagtga tcgctaccgg attcgccgac     1920

cttggatttg acgttgatat tggtcccttg ttccagaccc caagggaggt ggcccaacaa     1980

gccgtcgatg ccgatgtgca cgccgttggt atctctactc tcgcagcagg gcataagaca     2040

ctcgtgcccg agctcataaa ggaactgaat agcctcggtc gaccggatat actcgtcatg     2100

tgtgggggcg tgattccccc tcaggattat gagttcttgt ttgaggtggg cgtgagcaac     2160

gtcttcggtc caggcaccag aattcccaag gccgctgtgc aggtgttaga cgatattgaa     2220

aagtgcttgg aaaaaaagca gcagagcgtg                                      2250


<210>  103
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       WT mutation

<400>  103
atgttacgcg ctaagaacca gctgtttctg ctgagtcccc attacttgag acaggtaaag       60

gagtcatccg ggagcagatt gatacagcag cgtttgctgc accagcagca gccactgcat      120

ccggagtggg ccgccttagc caagaagcag ttaaagggga agaatcccga ggacctgatt      180

tggcacacac ccgaagggat ttctatcaag cctctctatt ctaaaaggga caccatggat      240

ctgcccgaag agctgccggg agtcaagccc ttcacaagag ggccataccc tacgatgtat      300

acattcagac catggacgat taggcagtac gctggattca gtactgtgga agaatcaaat      360

aaattctata aggacaatat caaggccggc caacaggggt tatcagtggc tttcgacctg      420

gctactcacc gaggctatga ctccgacaat ccccgggtcc ggggggacgt tggaatggca      480

ggagtggcaa tcgatacagt cgaggatacc aagatcctgt tcgatggtat ccctctggag      540

aaaatgtctg tctccatgac catgaacggg gcagttatcc ccgtgctggc taatttcatt      600

gtaacaggag aggagcaggg ggtaccgaag gagaagctta ccggtacgat acaaaatgat      660

atcctgaaag agtttatggt gaggaacact tacatcttcc cacctgagcc atctatgaaa      720

ataatcgcag acattttcga atataccgcc aaacatatgc ctaagttcaa ctcaatcagc      780

atctctggtt atcatatgca ggaggccggc gctgacgcca ttctcgaact ggcatataca      840

ctggcagacg gactggaata cagccgtact gggttacagg ctggtctcac tatcgacgaa      900

tttgccccgc gactgagctt cttctggggt atcggcatga acttttacat ggaaatagca      960

aagatgcgtg ctgggcgtcg cttatgggca cacctgatcg agaaaatgtt tcagcctaag     1020

aatagtaaaa gtttactctt aagggcacac tgtcagacaa gcggctggtc tttaaccgag     1080

caggatccct acaacaatat cgtgagaact gcgattgagg cgatggccgc agtttttggg     1140

gggacacagt ccttgcatac gaatagcttc gatgaggcac tggggctgcc tactgttaag     1200

agcgctagga ttgctcgaaa cactcaaatc atcattcagg aagagagcgg aatccctaag     1260

gtagctgacc cttggggtgg gtcgtatatg atggagtgtc tcaccaatga tgtgtatgat     1320

gcagcgttga agcttatcaa tgagattgag gagatgggcg ggatggccaa ggctgtggct     1380

gaagggatcc ctaaactgcg aatcgaagag tgtgcagcga gacgacaagc ccggattgac     1440

tccgggtcag aagtcattgt aggcgtgaat aagtatcagc tggagaaaga ggacgcggtt     1500

gaagtgctcg caatcgataa tacctctgtc cgcaatagac agatcgagaa attgaagaag     1560

atcaagtcca gccgggacca ggccctggcc gagaggtgtc tggccgccct gacggagtgt     1620

gcagcatcag gggatgggaa catactggct ctggccgtcg atgcttcccg ggcaagatgt     1680

accgtgggcg agatcaccga cgcactgaag aaggtgttcg gcgaacataa ggcaaacgat     1740

agaatggtat ccggcgccta ccggcaggag tttggagagt ccaaggagat cacatctgcc     1800

attaaaaggg tacataaatt catggaacgg gaaggtagga ggccaagact gctcgtcgct     1860

aagatggggc aggacggaca tgacaggggt gccaaggtga ttgctacagg gttcgctgac     1920

cttgggttcg acgtggacat aggccctctg tttcagacac ctcgagaggt ggcgcaacag     1980

gctgtcgacg ccgatgtgca tgccgttggg atttctacgc tggctgcggg tcataagacc     2040

ctagtgccag aattaattaa ggagttgaac tccttgggga ggccagacat cctcgttatg     2100

tgtggggggg tgattccccc tcaagactac gagttcctgt tcgaggtcgg agtttctaac     2160

gtgtttggcc cgggaacacg gatcccaaag gccgccgttc aggtgttaga tgacattgaa     2220

aagtgtctgg agaagaaaca gcaatcagtt                                      2250


<210>  104
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       WT mutation

<400>  104
atgctgcggg caaaaaacca attgtttctg ctatcccctc attaccttag acaggtcaaa       60

gaaagtagcg gatctcgcct catccagcaa cggctcctgc accagcagca acccctacac      120

cctgaatggg ccgcactggc taaaaaacaa ctgaaaggaa aaaaccctga agacttaatc      180

tggcacaccc ccgaaggcat ttctatcaaa cctctgtaca gtaaaagaga caccatggat      240

ctgccagaag aactgcccgg ggttaaacct ttcacccgcg gcccttatcc tactatgtat      300

acctttcgac catggactat ccgccagtat gcaggcttct ccactgtcga agagtcaaac      360

aagttctaca aggataatat taaggcaggt cagcagggac tgtcagtagc ttttgactta      420

gctactcata gaggctatga tagcgacaac cccagagtta gaggcgacgt aggaatggca      480

ggagtggcta tcgatacagt ggaggacaca aagattctgt ttgacgggat tcctttggag      540

aaaatgtccg tgtccatgac catgaacggt gctgtgatcc ctgtcctcgc taattttatc      600

gtgacagggg aggaacaggg cgtgcctaag gagaagctta caggtacaat acagaacgat      660

attctcaaag aattcatggt aagaaacact tacatatttc caccagagcc ctccatgaaa      720

atcattgcgg atatctttga gtacactgcg aagcacatgc ccaaattcaa tagcatcagt      780

attagcgggt accacatgca agaagctggg gcagatgcca tactggagct ggcctatacg      840

cttgccgatg ggcttgaata ttctcgcaca ggcttgcaag caggcctgac tatcgatgag      900

ttcgctccca ggttgagttt cttttggggt ataggcatga acttttatat ggagatcgca      960

aaaatgcgtg ctggaaggcg attgtgggct cacctcatcg agaaaatgtt ccagccaaag     1020

aactcaaagt ccctgcttct tcgggctcac tgccagacct ccggctggag tctgaccgaa     1080

caagacccat ataataacat tgttcggact gcaattgaag caatggcagc cgttttcgga     1140

ggcacccagt ccttgcacac caatagcttt gacgaggctc tcggactgcc aaccgttaag     1200

agtgctagaa tagctcgaaa tacacagata atcatccagg aagagtctgg tattcccaaa     1260

gtggccgacc cttggggcgg cagttacatg atggagtgtc tcaccaacga cgtgtacgat     1320

gcggccctga aattgataaa cgaaatagaa gagatgggtg gcatggcaaa ggcagtcgct     1380

gaagggatcc ctaagcttag gatagaagag tgcgcagcca ggaggcaggc caggatcgat     1440

tccggatcag aggtcattgt cggtgttaat aagtaccaac tggagaagga ggacgctgtg     1500

gaagtactgg caatcgacaa tacgtctgtg cggaacaggc agattgagaa gcttaagaaa     1560

atcaaatcct cccgagacca agcgctggcc gagcgatgtt tagcagctct gaccgagtgc     1620

gctgcatctg gtgatggcaa cattctggca ctggccgtag acgcctcccg ggccaggtgt     1680

acagtgggag aaatcaccga cgcccttaag aaagtgttcg gggagcacaa ggccaacgac     1740

agaatggtct ctggtgccta ccgacaagag ttcggagagt ccaaggaaat tacttctgcc     1800

atcaaaagag tacacaagtt catggaaaga gagggaagga gaccccgcct tctcgtggct     1860

aagatgggcc aggacggcca tgaccggggc gcaaaggtga tcgctactgg ctttgccgat     1920

ctcggttttg atgtagacat cggccctttg tttcagaccc cccgagaagt cgctcagcaa     1980

gccgtagacg ctgacgttca cgctgtcgga attagcacac ttgctgctgg acacaagacc     2040

ctcgttcctg aattaattaa ggagctgaac agcttgggcc gacccgacat cctagtgatg     2100

tgtggtggcg tgataccacc tcaagattat gaattcctgt tcgaagtggg agtttcaaac     2160

gtttttggcc ctggcactcg gattccaaag gcagccgtgc aggtcctaga tgacatcgag     2220

aagtgtcttg agaaaaagca gcagagcgtt                                      2250


<210>  105
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       WT mutation

<400>  105
atgctgagag ccaagaatca gttgtttttg ttgtccccac attatctcag gcaggtgaag       60

gagtcctccg ggtcaaggtt aattcagcag cgcttacttc accagcagca gcccttgcac      120

cccgaatggg ccgcgctcgc gaagaagcag ttgaaaggga aaaaccctga agacctcatt      180

tggcataccc ccgaaggcat tagcatcaaa ccactgtata gcaaacggga taccatggac      240

cttcccgaag aactccccgg agttaaacct tttactaggg ggccctaccc cactatgtat      300

acctttcggc cttggactat tcgacagtac gcgggattct ccacagtgga ggaatcaaat      360

aaattttata aggacaatat caaagctgga cagcagggcc tgagcgttgc cttcgacctc      420

gcaactcaca gaggctatga ttcagacaat ccgcgagtgc gcggcgatgt cggaatggct      480

ggagtagcga tcgatacagt tgaagacact aaaattctat tcgatggaat tcccctcgaa      540

aaaatgtccg tgtctatgac tatgaacggg gcagtgattc cagttcttgc caatttcatc      600

gttacaggtg aagaacaggg agtgcccaag gaaaaactca cagggaccat ccagaacgac      660

atcctcaagg aatttatggt acgcaacacc tacatatttc caccagaacc atctatgaaa      720

ataatcgctg atatcttcga gtatacagct aagcacatgc ccaaattcaa tagcatctct      780

atttcgggct atcacatgca agaggcaggc gccgatgcca ttctggaact cgcctacacc      840

ttggcggatg gcctcgagta ctctcggacc gggctacaag cggggctcac aattgatgaa      900

ttcgctcctc gcctgtcttt tttttgggga atcggtatga atttctacat ggaaatcgcg      960

aaaatgcgag caggtcggcg cctgtgggcc cacctgatcg agaagatgtt tcagcctaag     1020

aattcgaagt ctctgcttct gcgcgctcac tgtcagacat ccgggtggag tttgaccgaa     1080

caggacccat acaataatat agtgaggact gccattgaag caatggcagc cgtgttcggg     1140

ggtacccagt ccctccatac caattctttc gacgaagccc tgggactgcc taccgtgaag     1200

agcgccagaa tcgcaaggaa tacccagatt attattcagg aagaatccgg gatccccaag     1260

gtggccgacc catggggagg gtcctacatg atggaatgcc tcactaacga cgtgtatgat     1320

gcagccctta aactgatcaa cgagatagaa gagatggggg gaatggccaa ggcggtagct     1380

gagggcatcc ccaagctccg catcgaggag tgtgctgccc gcaggcaagc caggatagac     1440

tccgggagtg aggtcattgt aggtgttaac aagtaccagc tggagaaaga agacgccgtg     1500

gaggtccttg ccattgataa taccagcgtt aggaatcgac agatcgagaa gctgaaaaaa     1560

atcaaaagtt caagagatca agcattagca gaaaggtgtc tggctgcttt gacagagtgc     1620

gcagcctcag gggacgggaa cattcttgca ctcgctgtgg atgcctcacg ggctcggtgc     1680

actgttggcg agatcacaga tgccctgaaa aaagtgttcg gcgaacacaa agcaaacgat     1740

cggatggtga gtggagccta taggcaagag ttcggcgaga gcaaggaaat cacctcagcc     1800

attaaaaggg tgcacaagtt catggagcga gaaggccgga gaccaagact tcttgttgcg     1860

aagatgggcc aggacggcca cgatagagga gccaaggtca tcgctactgg attcgcagac     1920

ctcggattcg acgtcgacat cgggcccctg ttccagacac cccgtgaagt cgctcaacaa     1980

gcagtggatg ccgacgttca tgctgtcggc attagtacac tggccgccgg acacaagacc     2040

cttgtcccgg agttgattaa agagttgaac tccctgggcc ggcctgacat tttagtgatg     2100

tgcgggggcg tcattccacc ccaggactac gaatttctgt ttgaagtagg cgtgagcaac     2160

gtattcgggc ctggcacacg aattccaaaa gccgcagtgc aagtactgga cgatatagag     2220

aagtgtctgg agaaaaagca gcagtcagtg                                      2250


<210>  106
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       WT mutation

<400>  106
atgctgaggg ccaaaaacca gttgttccta ctgagccctc attatctcag gcaggtgaag       60

gagagttccg gttcccgtct gatccagcag cggctgctgc accagcaaca acctctccac      120

cccgagtggg ccgctctggc gaagaagcaa ctcaaaggaa agaatccaga ggatcttata      180

tggcatacac ctgaaggaat tagcattaag cccctctatt ccaagcgtga cacaatggac      240

ctgcctgagg aattacctgg agttaaaccc ttcacgcgcg gtccctaccc gacaatgtat      300

actttccgac cctggactat caggcagtac gcaggattca gcaccgtgga ggagtcaaac      360

aagttctata aggacaacat caaggccggc cagcaagggc tttctgttgc attcgacctg      420

gccacgcacc ggggttacga ctcggacaat ccaagggtcc ggggcgacgt cggcatggcg      480

ggagtggcca ttgacacagt agaggacacg aagattctat ttgacggtat ccctctcgag      540

aagatgtccg tctcaatgac catgaatggc gcagtcatcc ccgttttggc caatttcatc      600

gtcaccggtg aggagcaggg agtacctaaa gagaagctga cgggaacgat tcaaaacgat      660

atactgaagg aattcatggt ccgcaacact tatatttttc cccccgaacc aagcatgaag      720

ataatcgctg atatatttga gtacacagca aaacacatgc ccaagttcaa ctccataagt      780

atcagcgggt accatatgca ggaggccgga gctgacgcaa tcctggaact ggcatatacc      840

ctggcagacg ggttagagta cagcaggaca ggcttgcaag cgggcctcac aatagacgaa      900

tttgccccac gattgtcatt tttctggggc atcggaatga atttttatat ggaaatcgcc      960

aagatgcggg ccggacggcg gctctgggct cacctcatag agaaaatgtt tcagccaaaa     1020

aattcaaaaa gcctgcttct tcgggctcat tgtcagactt cagggtggtc cctgacggaa     1080

caggatccct ataacaacat tgtgcggaca gctatagaag caatggcggc cgtgttcggc     1140

ggcacgcagt ccctacacac taatagtttc gacgaggcct tgggcttgcc tacagtcaaa     1200

tccgccagaa tagccagaaa cactcagatt ataattcagg aagagagtgg catcccaaaa     1260

gtggcagatc catggggagg atcctatatg atggaatgtc tgaccaatga tgtctacgat     1320

gccgccttaa aactgataaa tgaaattgaa gagatgggag ggatggcaaa ggcagtggct     1380

gagggaattc cgaaactgcg gatcgaggaa tgcgctgcca ggagacaggc acggatcgat     1440

tctggttccg aggtgatcgt tggcgtcaat aaataccagc tcgagaaaga agacgccgtg     1500

gaggtgctcg cgatcgacaa tactagcgtc cggaaccgac aaattgagaa gcttaagaaa     1560

attaagagct caagagatca ggccctggca gagcggtgcc tagcagccct caccgagtgc     1620

gctgccagtg gtgatggaaa tattctggcc ctcgctgtgg acgcctctag agcgcggtgc     1680

acagttggcg aaatcactga cgctctcaag aaggtctttg gagaacataa ggccaacgac     1740

cggatggtct ccggcgctta tcgacaagaa ttcggagaat caaaagaaat cactagcgcc     1800

atcaagcgtg tccacaagtt catggagaga gagggtcgca gaccaagact gctggtggcg     1860

aaaatggggc aggacggaca tgatcgggga gccaaagtaa ttgctactgg ttttgcagat     1920

cttggctttg atgtggatat tggtccatta tttcagactc cccgcgaagt agctcagcag     1980

gcagtcgatg ctgatgtgca cgcagtggga atcagtacct tggccgcagg gcacaagacc     2040

ctagtgcccg aactaatcaa ggagctgaat tccctcggaa gaccggacat tttagtaatg     2100

tgcggcggcg tcataccccc acaggactac gagtttctgt ttgaggtagg agtgtctaac     2160

gtatttggcc ctgggactag gatccctaaa gctgctgtgc aggtgttgga cgatatcgaa     2220

aaatgtctcg aaaagaagca gcagtccgtt                                      2250


<210>  107
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       WT mutation

<400>  107
atgctccgcg ccaagaatca actcttcctg ctgtcccctc attatctgag acaagttaaa       60

gagagttccg gcagtcgctt aattcagcag agactgctcc atcagcagca gcctcttcac      120

ccagaatggg ccgcactggc taagaagcaa cttaagggaa aaaacccgga ggaccttatt      180

tggcacacac ccgaaggtat atctatcaag ccactgtaca gcaaaagaga tacgatggac      240

ctgccagagg agctccccgg ggtcaaaccg ttcaccagag ggccctaccc taccatgtac      300

acctttcgtc cgtggacaat taggcaatac gccggtttca gcacagtgga ggagagcaac      360

aagttctata aagataatat taaagccgga cagcaggggc ttagtgtggc ctttgactta      420

gccactcatc gggggtacga ctccgacaat cccagggtgc ggggcgacgt gggcatggcc      480

ggagtcgcaa tagatacagt cgaagacact aagattctct tcgacggcat tcctcttgaa      540

aaaatgtccg ttagtatgac catgaacggt gccgttatcc cagtcctcgc caacttcatc      600

gtgacaggag aggagcaggg agtgccaaaa gagaaactga ctgggactat ccagaatgac      660

atactaaaag agtttatggt tcgaaatacg tatatcttcc ctccggaacc cagcatgaag      720

atcattgcag acatctttga gtatactgca aaacacatgc ctaaatttaa ctccatctca      780

ataagcggat atcacatgca agaagcgggt gccgatgcca tccttgagtt agcttacaca      840

ttggcggatg gacttgaata ctcccgtact gggctccagg cagggctaac cattgatgag      900

tttgctccac gcctctcctt tttctggggt ataggcatga atttctacat ggagatagcc      960

aagatgcgtg ctggcagacg gttatgggcc caccttatag agaaaatgtt ccagccaaag     1020

aactccaaat cacttctgct ccgtgcccat tgccagacat ctggttggtc actgactgag     1080

caggatccat acaataatat cgtgcgcaca gcaatcgagg ctatggcggc agtgttcggc     1140

ggcacacagt cactccatac caattctttc gacgaggcac tcgggcttcc gactgtaaag     1200

tctgccagaa ttgcccgtaa cacacagatc attatccagg aagagagcgg aatccccaaa     1260

gtcgctgacc cctggggcgg ttcctatatg atggaatgtc tgaccaacga cgtgtacgac     1320

gctgccctga agctcatcaa tgagatcgaa gaaatgggag gtatggctaa agccgtcgca     1380

gagggcattc ctaagctgcg cattgaggaa tgtgccgcac ggaggcaggc cagaatcgac     1440

tcaggaagcg aagttatcgt gggagtgaat aagtaccagc tagaaaagga ggatgcagtc     1500

gaggttctcg ctatcgacaa taccagcgtg aggaataggc agattgagaa attaaaaaag     1560

attaaatcat caagggacca agcccttgcc gagagatgtc tggctgcgtt gacagagtgt     1620

gcggcctcgg gtgacgggaa cattctggcg ctggccgtgg atgcatccag ggctcgctgc     1680

actgtggggg aaattactga tgctctcaag aaggtattcg gagaacataa ggccaatgat     1740

aggatggtgt ccggggccta ccgccaagaa ttcggggaga gcaaagaaat caccagcgcc     1800

ataaagcgcg tgcacaaatt catggagagg gaaggaagaa gacctaggct cctggttgcc     1860

aagatggggc aggatggaca cgaccgggga gccaaggtca tagccactgg attcgccgac     1920

ctcggcttcg atgtcgacat cgggcccctg ttccagactc ccagagaagt ggcgcaacag     1980

gccgtcgacg cggacgtaca cgcagtgggt atatcaacac tggcggccgg ccacaagacc     2040

ctagtgccag agcttattaa agagctgaat tctctgggcc gtccagatat tctcgtgatg     2100

tgtggaggag tgatacctcc acaggactat gaatttctgt tcgaagtggg cgtgagcaat     2160

gtttttggcc cggggacccg gatcccaaaa gcagctgtgc aagtgcttga cgacatagag     2220

aaatgtctcg agaaaaaaca gcagtcagtc                                      2250


<210>  108
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       WT mutation

<400>  108
atgctcaggg ctaagaatca gctgttcctg ctgagccccc actacctgag gcaggtcaag       60

gagagctccg ggtctagact catacagcag cgactcctgc accaacagca accgctccat      120

cctgagtggg cggccttagc caaaaaacaa ctgaaaggga aaaatcctga ggatctgatt      180

tggcacactc ccgagggaat ctcaattaag ccactctata gcaaacggga cacaatggat      240

ttgcccgaag agctcccggg agttaagcca ttcacccgcg gcccttaccc taccatgtac      300

acatttcggc cctggactat aagacaatat gcagggttta gtactgtaga agaatccaat      360

aagttctata aagataacat caaggctggg cagcaaggac tctctgtagc tttcgaccta      420

gctacccaca gaggatatga tagcgataac ccaagagtgc gaggggacgt tggaatggca      480

ggcgtggcta tagacaccgt agaagataca aagattctgt ttgacggcat accactggag      540

aagatgagcg tgtccatgac catgaatggg gcggtgatac ccgtgctcgc caattttata      600

gtaacaggcg aagaacaagg cgtgcccaaa gaaaagctga caggtacaat ccagaacgac      660

attcttaaag aattcatggt tcgaaacacc tacatttttc cccctgagcc cagcatgaag      720

ataatcgctg atatctttga atacacagcc aagcacatgc ctaagtttaa cagtatctcc      780

atcagcggct accacatgca ggaggccggt gcagacgcta tcctggagct ggcctacact      840

ttggccgatg ggctggaata tagccgtact ggactgcagg cagggcttac aatcgacgag      900

ttcgcaccca ggttaagctt cttctggggc attggtatga atttttatat ggaaattgct      960

aagatgaggg caggccgcag gctgtgggcc cacttgattg agaagatgtt ccagccaaaa     1020

aacagcaaat ccttgttact gagggcacat tgtcagacat ccggatggtc cttaaccgag     1080

caggatccct acaataacat agtgagaacg gccatagaag caatggccgc tgtcttcgga     1140

ggcacccaat ccctacacac aaactctttc gatgaagcac tgggactccc cacagtgaag     1200

agcgctagaa ttgctcgcaa tacccaaata atcatccagg aggagagtgg cattcccaaa     1260

gtcgcagacc cgtggggagg ctcgtacatg atggagtgtc tcaccaatga tgtctatgac     1320

gctgcattga agctgataaa tgaaatcgaa gagatggggg ggatggcaaa agctgttgcc     1380

gaaggcatcc ctaagctgag gattgaggaa tgcgccgcgc gccgccaggc ccgtatagac     1440

agtgggtccg aggttatcgt tggggtgaat aagtatcagt tggaaaaaga agatgctgtt     1500

gaggtgcttg caattgacaa cacctccgtg cgaaatagac agattgagaa attgaagaaa     1560

atcaaatctt ctcgggacca agccctggcc gagcgatgtc tggctgcgct gaccgaatgt     1620

gcggcctccg gcgacggcaa cattctggcc ttggctgtgg atgcatcgcg cgctcgctgt     1680

acggtgggag agattactga cgcactcaag aaggtctttg gagaacacaa ggccaatgat     1740

cgaatggttt ccggcgcata ccgacaggaa ttcggtgagt ccaaggagat aactagcgcc     1800

ataaaacggg tgcataagtt catggaaaga gaagggcgaa ggcctagact gcttgttgct     1860

aaaatgggac aagatggtca tgatcgggga gctaaagtta tcgcgactgg atttgccgat     1920

ctcggatttg acgtggacat aggcccctta ttccagaccc cccgtgaggt cgctcagcag     1980

gccgtggacg ctgacgtgca tgccgtcggt atctcaaccc ttgccgccgg gcataagact     2040

ctggtgcccg aactcattaa agaactgaac tccctgggcc gccccgacat ccttgtcatg     2100

tgcggcggcg tcatcccacc ccaggattac gaatttctct tcgaagtggg tgtgagcaac     2160

gtctttggcc ctgggaccag aattccaaag gcagcggtcc aggtcctgga tgacatcgaa     2220

aagtgtctcg agaagaagca gcaaagcgtg                                      2250


<210>  109
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       WT mutation

<400>  109
atgctcaggg ccaaaaacca actgttcctc cttagcccgc actatctgag gcaagtcaaa       60

gagagcagcg gatcacgact aatccagcag aggctgttac accaacagca gcccctacat      120

cccgaatggg cagcactcgc taagaagcag ttgaagggta aaaaccctga agatctgatt      180

tggcacactc cagaggggat ttcaatcaaa cctttgtatt ctaagaggga taccatggat      240

ctgcctgagg aactgcctgg cgttaaacct ttcacccgag gaccgtatcc cacaatgtat      300

accttccggc cctggactat caggcaatac gcagggttct ctaccgtgga ggagtctaac      360

aaattctata aggataatat aaaggctggc cagcaggggc tgtcagtagc atttgatctg      420

gccacacacc gtgggtacga ctcagacaac cccagagtca ggggggacgt cgggatggcg      480

ggcgtggcta tagatactgt agaggacacg aaaattttat tcgacggtat tccactggaa      540

aagatgagtg tgtctatgac aatgaacggc gctgtgatcc cagtgctcgc caactttatt      600

gtcaccgggg aagagcaggg agtgcccaaa gagaaactga ccggcaccat ccagaatgat      660

atcctgaaag aattcatggt ccgaaacaca tacatctttc cgcctgaacc ctctatgaag      720

atcattgctg acatattcga atacaccgcc aaacacatgc ccaagttcaa tagcatttcc      780

atttcaggat accacatgca ggaggctgga gccgatgcta ttcttgagtt ggcttacaca      840

ctcgccgacg ggctggagta ttcccgtaca gggcttcagg ccggacttac cattgacgag      900

tttgcgccaa gattatcatt tttttgggga attggtatga atttctacat ggagattgcc      960

aaaatgcggg cagggaggcg gctctgggcc cacctgattg aaaagatgtt tcagcctaaa     1020

aactcaaaat ctctgttact gagggcccat tgtcagacct ccggatggag cttaactgag     1080

caggacccat acaacaatat cgtacgaacc gcaatagagg ccatggccgc cgtgttcggc     1140

ggcacccaaa gcctgcacac caatagcttc gatgaggccc taggcctacc gacagtgaaa     1200

agcgcaagga ttgcgcgtaa cacgcagatt attattcagg aggagagtgg catacccaaa     1260

gttgccgacc cttggggagg ctcgtacatg atggagtgct tgactaatga tgtatacgat     1320

gcagcactca agttaatcaa cgagatagaa gagatggggg gaatggccaa ggccgtggcg     1380

gagggtattc ccaagctccg tatcgaggag tgtgctgccc gtcgccaagc ccgtatcgat     1440

agtggatctg aagttatagt gggcgtcaac aagtatcagt tggagaagga ggacgctgtg     1500

gaagtgctcg caatagacaa cacctctgtg aggaatcgac agatagagaa actcaagaaa     1560

atcaaatcta gtagagacca ggcgctcgcc gagagatgcc ttgctgcttt aacagaatgc     1620

gctgctagcg gcgacggaaa catcctagcc cttgccgttg acgcctcaag ggctcgatgc     1680

acagtcggcg agattacgga cgccctgaaa aaggtattcg gcgagcacaa agccaacgac     1740

cggatggttt caggagccta tcgccaggag ttcggagaat ccaaagaaat aacatccgct     1800

attaaaagag tgcacaaatt tatggaacgg gagggtcgaa ggccccgact tctcgtcgcg     1860

aagatgggcc aggacggcca tgatcgcggg gcgaaggtaa ttgccaccgg cttcgccgat     1920

ctcggtttcg atgtcgatat cggacctctg ttccagactc cgcgagaggt agcccagcag     1980

gctgtggatg cagacgtgca tgctgtaggg attagtactt tagccgcagg ccacaaaacc     2040

ctggttcctg aattaatcaa ggagctgaac tcccttggga ggccggatat attggttatg     2100

tgcggcggag ttatacctcc ccaggactac gagttcctgt ttgaggttgg tgtatctaac     2160

gtctttgggc ccggaacacg gatccccaaa gctgcggtac aggtactcga tgacatcgaa     2220

aagtgtttag aaaagaaaca gcagagtgtg                                      2250


<210>  110
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       WT mutation

<400>  110
atgctgaggg ccaagaacca actgtttctg ctcagcccgc actaccttag gcaggtgaag       60

gagagttccg ggagtagatt aatacagcaa cgtttgttgc accagcaaca gccccttcac      120

ccggagtggg ccgccctggc aaagaaacag ctgaagggaa agaaccccga ggatctaatt      180

tggcacaccc cagagggtat ctccattaag ccgctctaca gcaagcgcga caccatggac      240

ctcccagaag agctgcctgg tgtcaagccg tttactagag ggccataccc cactatgtat      300

acattccggc cctggactat cagacagtat gccgggttct caacagtcga ggaatctaac      360

aagttctata aggacaacat aaaagcgggc cagcagggac ttagcgtagc cttcgacctc      420

gctacccacc ggggctacga cagcgacaat cccagagtaa ggggcgatgt tgggatggca      480

ggtgtggcca tcgatacagt ggaagatacc aaaatccttt tcgacggaat tcccctcgaa      540

aaaatgtccg tcagtatgac aatgaatggc gccgtgattc ccgtactggc taatttcatt      600

gtgaccggag aggagcaggg cgttcccaag gagaagttga ctggaacaat tcagaatgac      660

attctgaagg agtttatggt gcgcaacacc tacatttttc ctcctgaacc ctctatgaag      720

atcatagctg atatttttga gtacaccgca aagcacatgc ctaagttcaa tagcattagt      780

atcagcgggt atcatatgca ggaagccggt gctgacgcta tcctggaatt agcctacacg      840

ctcgcagatg gcctcgagta ctctcgaacc gggctgcagg caggcctgac aattgatgag      900

tttgcccctc gattatcctt cttttggggc attgggatga atttctatat ggagattgcc      960

aagatgcgcg cgggccggag gttatgggcc catttgattg aaaagatgtt ccagcccaag     1020

aattccaagt ccctgctgct ccgggcacat tgccaaacgt ccggctggag cctgacggag     1080

caagacccct ataacaatat cgtgaggacg gcgatagagg ccatggctgc tgttttcggc     1140

ggtacgcaat ccctgcacac gaactcattc gatgaagccc ttgggcttcc tactgttaaa     1200

tccgcgagaa ttgcaagaaa tacccagata ataattcagg aagagagcgg catccctaag     1260

gtagctgatc cttggggcgg gtcctacatg atggagtgtc tgactaatga cgtctacgat     1320

gccgcattga aattaatcaa tgagatcgag gagatgggag gaatggccaa agccgtggcc     1380

gagggcatcc ccaagctccg gattgaggag tgcgcagccc gacgacaggc ccgtatcgat     1440

tcaggttcag aggtgattgt cggagtaaac aagtaccagc ttgagaaaga ggatgcagta     1500

gaagtcctgg caatagacaa tacatcagtg cgcaatagac agattgagaa actcaagaaa     1560

attaagtcct caagggatca ggctctggca gagcggtgcc tagcagctct tacggaatgt     1620

gccgccagcg gcgacggaaa catattggcg ctagcggtgg atgcaagcag ggcaagatgt     1680

actgtcggcg agatcactga tgccctgaag aaggtgtttg gcgagcacaa ggctaatgat     1740

cgcatggtct ctggagcata caggcaagaa ttcggtgaat ctaaggaaat cacatccgcc     1800

ataaaaaggg tgcacaagtt tatggagcgg gaaggcagga ggccccgtct gctcgtggct     1860

aaaatggggc aggacggcca tgacaggggc gcaaaggtta ttgccactgg cttcgcagat     1920

ttaggatttg acgtggacat cggacccttg ttccaaaccc cacgagaggt ggcacaacaa     1980

gctgtggacg ctgatgtaca tgccgtggga atctccaccc ttgccgctgg acacaaaacc     2040

ctggtgcccg aactgatcaa ggaactaaat tcccttggcc ggccagatat cctggtgatg     2100

tgcggcggcg tgataccacc tcaggattac gagttcctat ttgaagttgg ggtatctaat     2160

gtgttcggtc ctggcacacg tattccaaaa gccgcggtcc aggttctgga cgatattgaa     2220

aaatgtcttg agaaaaaaca gcagtcagtg                                      2250


<210>  111
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I69V mutation

<400>  111
atgcttcgtg ctaaaaacca actgttttta ttgtctcccc actacctgcg acaggtaaaa       60

gagtccagcg gatcccgtct aatccagcaa cgtttgttgc atcagcaaca gcccctgcac      120

cccgaatggg ccgcactggc gaaaaagcaa ctcaagggca aaaatccaga ggacttaatt      180

tggcataccc ccgaagggat ttccgtgaag cccctctatt ccaaacggga tacaatggat      240

ttgcccgagg aactcccagg tgtgaaaccc tttacaaggg gcccataccc caccatgtat      300

acattccgac cctggactat taggcagtac gcggggttct ctacagttga agaatcaaac      360

aaattctata aggacaatat taaggccggc cagcagggcc tgagcgttgc ttttgacctc      420

gccacccaca ggggctatga tagcgacaac cctcgcgtca ggggggatgt gggcatggcc      480

ggggtggcca tagacaccgt ggaggacacg aaaattttgt tcgatggaat cccactcgag      540

aagatgtccg tgagtatgac catgaacggc gctgttatcc ctgtgctggc aaactttatc      600

gttaccggcg aggaacaggg agttccaaag gaaaagctca caggtaccat tcaaaatgat      660

atcttgaagg aattcatggt acgaaacacg tatattttcc ctcccgagcc aagtatgaag      720

atcattgccg acatcttcga gtataccgcg aagcatatgc caaaattcaa ttctatcagt      780

atttctgggt atcacatgca ggaggctggt gcagacgcta tcctcgagct cgcctatact      840

ctcgcagatg gcctggaata cagccgtact ggtcttcaag ccggcctcac aattgacgaa      900

tttgcccctc ggctcagttt tttctggggt atcggcatga atttctatat ggagatcgcc      960

aaaatgagag ctggtaggcg cctgtgggct catctgatcg aaaaaatgtt tcaacctaag     1020

aactctaaga gcctcctcct gcgggcacac tgtcaaacat ccggttggag cctgacagaa     1080

caagatccct acaataacat tgtccggact gccatagaag cgatggccgc ggtctttggc     1140

ggcacacagt ctcttcatac aaattccttt gatgaggcac tgggactgcc cacggtgaag     1200

agtgcacgga ttgcgaggaa tactcagata attatccagg aagaatccgg tataccaaaa     1260

gtcgccgatc cttggggagg ttcctatatg atggaatgtc tgactaacga cgtctatgac     1320

gccgcactaa agctaataaa tgagatagag gagatgggcg gtatggcaaa agctgtggcc     1380

gaggggattc ctaaacttcg gattgaggag tgtgccgccc gcaggcaagc ccggatcgac     1440

tcagggtcgg aggtgatcgt gggcgtaaac aagtatcagc tcgaaaagga ggacgccgta     1500

gaagtcctcg ccattgacaa tacctcggtg cgcaaccgcc agatcgagaa gctaaagaag     1560

ataaagtcgt ccagagacca ggcgctggct gagaggtgcc tggctgcctt aaccgagtgt     1620

gcagcgtccg gcgacgggaa tatcctggcc ttggcggtgg atgcctctag agcgaggtgt     1680

accgtgggcg agattacaga cgccctaaaa aaggtgtttg gtgagcacaa ggccaatgat     1740

agaatggtct caggggccta tcggcaagaa ttcggtgagt caaaggagat cacctctgcc     1800

atcaaaagag tgcacaaatt catggaaagg gagggcagga ggcccagatt acttgttgcc     1860

aagatgggcc aggacggcca tgaccgtggc gctaaggtga ttgctacagg ctttgcagat     1920

ttgggattcg acgtagatat tggcccgctc tttcagacgc ctcgtgaggt ggcccagcag     1980

gcagtagatg ccgatgtcca tgccgtaggg atcagcactc ttgcagccgg acataagact     2040

ttggttccag aattgataaa ggagctcaac tctctgggcc gccctgacat cttggttatg     2100

tgtggcgggg taatcccccc acaggattac gaatttctct tcgaggtagg agtatcaaat     2160

gtcttcgggc caggaacccg catcccaaaa gctgccgtgc aggtcctcga cgacatcgaa     2220

aaatgcttgg agaaaaaaca acagagcgtg                                      2250


<210>  112
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I69V mutation

<400>  112
atgcttcggg caaagaatca gttgttcctg ttgtctcccc actacttgag acaggttaaa       60

gaatcctctg gctcacgcct catccagcag aggctgcttc accaacagca gcctctgcac      120

cctgagtggg cagccctggc taaaaaacag ctaaaaggaa agaatcctga ggatctgatc      180

tggcacaccc ctgaggggat ttcagttaaa ccactgtact ccaagaggga cacgatggat      240

ctgcccgagg aacttccggg ggtgaagccg ttcacccgcg gcccataccc tactatgtac      300

acattccggc cgtggacaat tcggcagtat gcaggatttt ctacagtaga ggaaagcaat      360

aagttctaca aagataatat taaggctggt cagcagggtc tgtcagttgc cttcgacctg      420

gcaacccaca ggggatacga ctccgataat ccgcgggttc gtggggatgt cggcatggct      480

ggcgtcgcca tcgatacagt tgaggacacc aaaattctgt ttgatggaat cccccttgaa      540

aaaatgtcag tgtccatgac catgaatggg gccgtgattc ctgtcctggc caattttatc      600

gtgaccggcg aagagcaagg agtgccaaag gaaaaactga ccggtacgat ccagaatgac      660

atattgaaag aattcatggt ccgcaacacg tatattttcc cacccgaacc ttctatgaag      720

atcatcgcgg atatctttga gtacacagct aaacacatgc caaagttcaa cagtatctca      780

atcagcggat accacatgca agaggccggc gctgatgcaa ttctggagct ggcctacact      840

cttgccgacg gactggaata cagccggacg gggctccagg ctggtcttac aatcgatgaa      900

ttcgcacccc ggcttagttt cttttggggg atcggcatga acttttacat ggagattgcc      960

aaaatgaggg ctggtcggcg cctctgggca catcttattg agaagatgtt tcagcccaaa     1020

aactctaaga gtttactgct tagggcccat tgtcaaacaa gcgggtggag tctgacagag     1080

caggaccctt ataataacat cgttaggacc gccattgaag cgatggcggc agtatttgga     1140

ggcacccaga gcctgcacac taacagtttc gatgaagcac ttggcctgcc tacagtcaag     1200

agcgctcgaa tcgctcgtaa cacccagata atcattcagg aggagagtgg catacccaaa     1260

gtggccgatc cctggggcgg atcttacatg atggagtgtt taaccaacga tgtatatgac     1320

gccgccttaa aactaattaa tgaaattgaa gaaatgggag gaatggcaaa ggcggtggct     1380

gaaggcatcc ccaagcttcg gatcgaggag tgtgccgcta gacggcaggc acgtattgac     1440

tcaggaagtg aagtaattgt gggagtgaac aaatatcagt tggaaaaaga agacgccgtg     1500

gaagtgctcg ccattgacaa cacctccgtg cggaaccgtc agatcgaaaa gctgaagaag     1560

attaagtcta gccgggacca ggctctcgca gaaaggtgtc tggccgccct taccgaatgc     1620

gccgcgagtg gcgacggcaa cattctggca ctggccgtcg acgcatctcg ggctcgctgc     1680

accgtaggag aaatcacgga cgctctgaag aaggtgttcg gagaacacaa ggctaacgac     1740

cggatggtct ccggcgctta taggcaggag tttggggaat ccaaagaaat taccagtgcc     1800

ataaaacggg tccacaaatt catggagagg gagggccggc ggcctcggct tctcgtggcc     1860

aaaatggggc aggacggaca cgatcgaggt gcaaaggtca tagcaactgg tttcgccgac     1920

ctgggattcg atgttgatat cggaccttta tttcagactc ctcgcgaagt ggctcaacag     1980

gccgtcgacg ctgacgtgca cgccgtgggg atctcaactc tagcagcagg ccataaaact     2040

ctggttccgg aactcattaa agaactcaat tcgctggggc ggccagacat cctggttatg     2100

tgcggaggtg ttatcccccc ccaagattac gagttcctgt tcgaggtcgg cgtcagcaat     2160

gtgttcgggc caggtacgag gatccctaaa gccgctgtac aggttctgga tgatattgag     2220

aaatgtcttg agaaaaaaca gcaatccgtc                                      2250


<210>  113
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I69V mutation

<400>  113
atgctaaggg caaagaatca gctcttcctg ctatcacctc actatctcag acaggtgaaa       60

gaatcttctg ggtccaggct catacaacag agattgcttc atcaacaaca accgctgcat      120

cctgagtggg ctgctctggc taaaaagcag ttgaagggca aaaaccccga ggacctcatc      180

tggcatacac cagaaggcat ttcagtcaag cccctctata gtaagaggga tactatggat      240

ctgcccgagg agctgcccgg tgtaaaaccg tttacacggg gcccataccc aaccatgtat      300

accttcaggc cttggacaat ccgtcagtat gctggcttct ccacggttga ggaatctaac      360

aagttttaca aggataacat caaagctgga cagcagggtc tgagtgtggc attcgactta      420

gcaacacatc ggggatacga cagtgacaat ccccgggtga gaggcgacgt gggcatggcg      480

ggagtggcta ttgatacagt cgaagatact aaaatcttgt ttgatgggat tcccctggag      540

aagatgagcg tgtcgatgac catgaacggg gctgttatcc ctgtgcttgc aaactttata      600

gtaacagggg aggaacaggg cgtgcctaag gagaagttga ccggcaccat ccagaacgat      660

attcttaagg agttcatggt gaggaataca tatatcttcc ctccagagcc aagtatgaag      720

atcatagccg atatttttga atataccgcc aagcacatgc ccaaattcaa ttctatctca      780

atttcaggct atcatatgca ggaggccgga gcagacgcta ttctggagct tgcatacaca      840

ctcgcagatg gcctcgaata ctcccgaacc ggactccagg caggccttac gatcgacgag      900

ttcgctccgc gattatcctt cttctggggg atcggcatga acttttatat ggaaattgcc      960

aagatgagag ccggaaggag gctgtgggca cacctcatag agaaaatgtt tcagccgaaa     1020

aatagcaaga gcttgctgct tagagcacat tgccaaacct caggctggag cctgaccgaa     1080

caggacccat ataacaatat cgtgcgcacc gccatcgaag caatggcagc tgtgtttggc     1140

ggcacccaaa gccttcatac caattcattt gacgaggctc tgggcctgcc caccgtcaag     1200

agcgcccgta ttgcccgcaa cacacagatc attattcaag aggagagtgg catacccaag     1260

gtggcggacc cctggggcgg gtcgtatatg atggagtgcc tgaccaacga cgtctatgac     1320

gccgcgctga agcttattaa cgagatcgaa gagatgggcg ggatggccaa agccgtagca     1380

gagggcattc caaaacttcg aatcgaggaa tgtgcagcca ggcgacaggc acgcatcgac     1440

tccggctcag aggtcatcgt cggcgtcaat aaataccaac tagaaaagga agacgcagtg     1500

gaggtgctgg cgattgacaa taccagcgtc cgcaatagac agatcgagaa gctcaagaaa     1560

attaaaagtt ccagggatca ggcgctcgca gagcggtgtc ttgctgccct aaccgaatgt     1620

gccgcttcgg gggatggcaa tattctggca ttggccgtgg acgccagtag agcacggtgt     1680

accgttggag agattacaga cgccttaaaa aaggtcttcg gcgagcataa agctaacgac     1740

aggatggtct ccggcgctta ccggcaggaa tttggcgaga gtaaagagat taccagcgcc     1800

attaagcgcg tacataagtt catggaaaga gaagggcggc ggcctcgact cctggtggcc     1860

aaaatgggac aggacggtca tgaccggggt gctaaagtca ttgcaacggg tttcgcagac     1920

ctcggttttg atgttgacat cgggccgctc ttccagacac ccagagaagt agctcagcag     1980

gcagttgatg cggatgtaca tgcggtgggc atcagtacgc tggcggcagg ccacaagacc     2040

ctggtgccag aattaatcaa ggagctcaat agtctgggtc gcccagacat tctggtaatg     2100

tgcgggggag taatcccacc ccaagattac gaattcctgt tcgaggtcgg cgtcagcaac     2160

gtctttggtc cagggactcg catccctaaa gccgctgtgc aggtgctgga tgacatcgaa     2220

aaatgcctag agaaaaagca gcaatccgtg                                      2250


<210>  114
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I69V mutation

<400>  114
atgctgcgcg ccaagaatca gttgtttctg ctgagcccac actatttgcg tcaagttaag       60

gagtccagcg ggtcccggct gatacagcag aggctgctgc accagcagca gcccttgcac      120

ccagaatggg ccgctttggc caagaaacag ctgaaaggga aaaaccccga agacctcatt      180

tggcataccc cagaagggat ttctgtcaaa ccactctatt caaagaggga caccatggat      240

ctgcctgagg agctgcctgg cgtgaaacct ttcacaagag gcccataccc aaccatgtat      300

acattcaggc catggaccat ccgccagtat gctggtttct ccaccgtaga agagtccaat      360

aagttttata aggataatat aaaagcagga caacagggac tgtcagtcgc cttcgatctg      420

gccacgcata gggggtacga cagtgataac ccacgggtgc ggggtgacgt cggaatggct      480

ggagtggcca tcgacaccgt tgaggataca aaaatcctgt ttgatggtat ccctctcgaa      540

aaaatgagcg tgtcaatgac gatgaatggc gctgtcatcc cagttttggc caactttatt      600

gtgacgggtg aggagcaggg tgtgcccaag gagaaactca ccggcacaat ccagaatgat      660

attttgaagg aatttatggt aagaaacact tatatcttcc cacccgagcc gagcatgaaa      720

attatcgccg acatttttga gtacacagcc aagcacatgc ctaaattcaa tagcatctcg      780

atctctggat atcacatgca ggaagccggc gctgatgcca tactcgagct cgcctacaca      840

cttgccgacg gactcgagta cagccgaact ggccttcagg ccggtctgac tatcgacgaa      900

ttcgctccta gactgtcgtt cttttggggc attgggatga atttctatat ggagatcgcc      960

aaaatgcggg ccggacgcag actctgggct catctcattg agaagatgtt tcaacccaaa     1020

aattcaaaat cccttctcct gagggcccat tgccagacaa gcggctggtc cctcacagag     1080

caggaccctt ataacaatat cgttagaacc gccattgaag ccatggccgc tgtgtttgga     1140

ggcactcaat ctttacatac aaattccttt gacgaggctt tagggttgcc taccgtcaaa     1200

tccgccagaa ttgccaggaa cacacagatt attatccaag aagagtccgg aatccccaaa     1260

gtggctgacc cctggggtgg tagttatatg atggaatgtt tgactaacga tgtatacgat     1320

gccgccctga aactgatcaa tgagatcgag gagatgggcg gtatggcaaa ggccgtcgcc     1380

gaaggcattc caaagctgcg gatagaggag tgcgctgccc gtagacaggc ccgaatagac     1440

agcggctctg aggtaatcgt gggggtcaac aagtaccagt tggaaaagga ggacgctgtc     1500

gaggttctgg ccattgacaa caccagcgtc cggaaccgcc agattgagaa gctgaagaag     1560

attaagagtt cccgggacca ggccttagcc gagcggtgtt tggcagccct cacagaatgt     1620

gctgcctcgg gcgacggcaa tattctggcc ctcgctgtcg atgcatccag ggcacgctgc     1680

acagtggggg aaattacaga tgcactgaag aaggtattcg gcgagcataa ggccaatgac     1740

cgtatggtca gtggggccta taggcaagaa tttggtgagt ccaaggagat tacatcagcc     1800

ataaagagag ttcataagtt tatggagaga gaggggcggc ggccacgtct tctggttgct     1860

aaaatggggc aagatggaca cgatcgtggg gccaaagtga tcgcaaccgg cttcgctgac     1920

ctggggttcg acgtggatat cggccctctg ttccagactc cccgcgaagt ggctcagcaa     1980

gctgtggatg cagatgttca cgctgttggg atttcaacac tggccgccgg acacaagacg     2040

ttggtgcccg agctgattaa agaactgaac tcactgggaa gacccgacat cctggtgatg     2100

tgcggggggg tcatcccccc gcaggactat gagttcctgt ttgaggttgg cgttagcaat     2160

gtttttggcc ctggcactcg tattccaaaa gctgctgtgc aggtgcttga cgatatcgag     2220

aagtgccttg agaagaaaca gcagagtgtg                                      2250


<210>  115
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I69V mutation

<400>  115
atgctcaggg ccaagaacca actgtttctt ctgtctcctc actatctgcg ccaagtaaag       60

gagtccagcg gaagtcgctt gatccagcaa cggttattgc atcagcagca gcccttacac      120

cccgaatggg ccgccctggc caagaagcaa ctgaagggca agaaccctga agatcttatc      180

tggcacaccc ctgaaggcat ttcggttaaa cccctgtata gcaaacggga taccatggat      240

ttgccagaag aacttcccgg cgtgaagccc ttcacccgcg gcccataccc tactatgtat      300

actttccggc catggacaat taggcaatac gcgggctttt ccactgtaga ggaatctaat      360

aagttctaca aggacaatat caaggctggc cagcaaggac tcagcgtagc attcgacttg      420

gccacgcata gaggctatga cagcgacaat ccccgcgtaa ggggagacgt ggggatggcc      480

ggagtggcca tcgacaccgt ggaggatacg aagatcctgt ttgacggaat cccattggaa      540

aaaatgagcg tgtctatgac catgaacggc gccgttatcc ccgtcctcgc aaattttatc      600

gtgacggggg aggagcaggg ggtgcccaaa gagaagctga ccggaactat tcagaacgat      660

attctgaagg agttcatggt cagaaacact tacattttcc ctcctgagcc atcaatgaaa      720

atcatcgccg atatctttga atacacagcg aaacatatgc ctaagttcaa tagcatctct      780

attagtggct accacatgca ggaagctgga gccgatgcta tcctggaatt agcttacacg      840

ttggcagatg ggctcgaata cagccgcacc ggccttcagg ctgggctcac tatcgatgag      900

tttgcgccac gcctgtcatt tttttggggt attgggatga atttttacat ggaaatcgca      960

aagatgagag ccggccggag attgtgggcc catctgattg agaagatgtt ccaacccaag     1020

aattccaagt ccttgttatt acgcgcacat tgtcagacca gtggttggag tctcactgag     1080

caggatcctt ataataatat cgtgcgcacc gctattgagg ctatggcggc cgtttttggt     1140

gggacccaga gtctacacac aaatagcttt gacgaggcct taggacttcc gaccgtgaag     1200

tcagcgcgca tagcccgcaa cacgcagatc attattcaag aggaatccgg gatccctaaa     1260

gtcgccgacc cctggggcgg atcatacatg atggaatgtc tgacgaacga tgtgtatgac     1320

gccgccctca agcttatcaa cgagatcgag gagatgggtg gtatggcaaa agccgtggcc     1380

gaagggatcc ctaagctcag gattgaggag tgtgcagcca gacgccaggc ccgcatcgac     1440

tcaggtagtg aggtgatcgt cggggtgaac aagtaccagc tcgaaaagga ggacgccgtt     1500

gaggtcctcg ctattgacaa cacctccgtc aggaataggc aaattgagaa attaaagaag     1560

attaagtcct cccgggacca agccttagcc gaaagatgtc tggcagctct gaccgagtgc     1620

gcggcaagcg gcgacggcaa catactggct ctggctgtgg acgcctccag ggcacgttgt     1680

accgttggcg aaatcaccga tgcactgaaa aaagtgtttg gggaacataa agccaacgac     1740

aggatggtat ccggagctta tcgccaggaa tttggagagt ctaaggagat tacgtcggca     1800

atcaagcgag tgcacaagtt catggagcgg gagggcagga gaccgaggtt attggtggct     1860

aagatgggac aggacggcca cgatcgcgga gctaaagtga tcgctaccgg atttgcagac     1920

ctgggtttcg acgtagatat tggtcccctg tttcaaaccc caagggaggt cgctcaacag     1980

gccgtcgatg ctgatgtgca cgctgtgggc atcagcacct tggctgctgg acacaaaact     2040

cttgtgcccg aactgatcaa ggagcttaat tcactgggaa ggcccgacat cctggtgatg     2100

tgcggaggag tgatcccacc tcaggattac gagttcctct ttgaggttgg ggtgtctaat     2160

gtgttcggtc ccgggacccg tatcccaaaa gcggctgtcc aggtccttga cgatatcgag     2220

aaatgcctag agaagaaaca acagagcgtc                                      2250


<210>  116
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I69V mutation

<400>  116
atgctacggg ccaaaaatca gctgttcctg ctcagtcccc actatctgcg ccaggtgaag       60

gagtctagcg gctcaaggct gatacagcaa cggctcctgc atcagcaaca gcctctgcac      120

cccgaatggg cagcccttgc caaaaaacaa ctcaagggca agaatccaga ggatttgatt      180

tggcacacgc ctgaagggat cagcgtaaag ccgctttact ctaaacgcga cactatggac      240

ctgccagaag aactgccggg agtgaagccc ttcacgcggg gtccataccc caccatgtac      300

acctttcggc catggactat tagacagtac gccgggttca gtaccgtgga ggagtctaat      360

aagttttaca aggataatat caaggctgga cagcagggtt tgagcgtggc ctttgacctt      420

gcaacccacc gggggtacga cagcgacaac ccccgggtga ggggggacgt aggtatggcc      480

ggggtggcaa ttgacaccgt agaagatact aagattttgt tcgatggaat tcctttggag      540

aaaatgagtg tgtctatgac catgaacgga gcagtgatac ccgttctagc caattttatt      600

gtgaccgggg aggagcaagg tgtgcctaaa gagaaactga ctggcacaat tcagaacgat      660

atcctgaagg agttcatggt tagaaacaca tatatatttc ccccagaacc gagtatgaag      720

attatagccg atatcttcga atatacagca aaacacatgc ctaaatttaa tagcatctca      780

atctccggtt atcatatgca ggaagcagga gccgatgcga tactggagtt agcttacacg      840

ctcgccgacg gcttagaata ttcaagaact gggttacagg cagggctaac aatcgatgag      900

tttgccccaa gactgtcctt cttttgggga atcggaatga acttttacat ggaaattgcc      960

aaaatgaggg ccggaagacg gctttgggca catttgatcg agaagatgtt tcagcccaag     1020

aactccaaga gtctcttgct gcgagcgcac tgtcaaactt ccggttggag cctcaccgag     1080

caagacccgt ataacaacat cgtcaggact gcaattgaag ccatggctgc agttttcggt     1140

gggacacaat ctctgcacac caattccttt gacgaagcac tggggcttcc gaccgtgaag     1200

tcagctcgga tcgctagaaa tacccagata attatccagg aagaaagtgg catccctaag     1260

gtggctgatc cttggggcgg gagttatatg atggagtgtc ttacaaatga tgtctacgac     1320

gcggcgctta agctgatcaa cgaaattgag gaaatgggag gaatggcaaa ggccgtcgct     1380

gaaggcatac ccaagttgag gatcgaggaa tgtgctgccc gcaggcaagc cagaattgac     1440

agcgggtcag aggtgatagt cggcgtgaac aagtaccagc tcgaaaaaga agatgctgtc     1500

gaagttttgg caatagataa tacttccgta aggaaccgcc agatagaaaa gctcaaaaag     1560

attaagagtt caagggacca ggcattagca gagaggtgcc tggcagccct gactgagtgt     1620

gccgcgtcag gggacgggaa tatactggcc ctggctgttg acgcaagtag agcccgctgt     1680

accgtgggag aaatcacaga cgcccttaaa aaggttttcg gtgaacacaa ggccaacgat     1740

cggatggtgt ccggcgccta ccggcaggaa tttggcgaat ctaaggaaat cacctcagcc     1800

attaagcgcg ttcacaagtt tatggaaagg gaagggcgga gaccaaggct gctggtggcc     1860

aaaatggggc aggacggaca cgatagaggc gcaaaagtga ttgcaaccgg ctttgccgat     1920

ttaggcttcg acgtcgacat cgggccactg tttcaaactc cccgagaagt ggcccaacag     1980

gcagttgatg ctgatgttca tgccgttggc atttctaccc tggccgcagg acacaaaacc     2040

ctcgtccccg agttgatcaa agaattaaac agtctgggga gacctgatat actggtcatg     2100

tgcgggggag tgattccccc ccaggactac gaattcttat tcgaggtggg tgtgagcaat     2160

gtcttcggac cagggacacg gatacccaag gccgccgttc aggtgctgga cgacatcgag     2220

aaatgtttgg aaaaaaaaca gcagtccgtt                                      2250


<210>  117
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I69V mutation

<400>  117
atgctgcgcg ctaaaaacca gctgttcttg ttgtcacctc actacctccg acaggtgaaa       60

gaatccagcg gttccaggct gatccagcag cgtctgctgc atcaacaaca gccccttcac      120

cctgagtggg ctgccttagc taagaagcag ttaaagggaa aaaacccaga ggatctcatc      180

tggcacaccc cagagggcat ctctgtgaag cccttataca gcaagagaga taccatggac      240

ctacccgagg agcttcccgg agttaagccc tttactcgag gtccttatcc tactatgtac      300

actttcaggc catggacgat caggcagtac gccggctttt ccaccgtgga agagtcaaat      360

aaattttaca aggacaacat caaggctggc caacagggac tctcagtagc tttcgacctc      420

gccacccacc gcggatatga cagtgacaat ccacgcgtga gaggcgacgt cggaatggcc      480

ggagtcgcta tcgacacagt ggaggatact aaaatcctct ttgacggaat ccctctcgaa      540

aaaatgtctg tgtccatgac gatgaatggc gcagtgatcc cagtgttggc taatttcata      600

gtgaccggcg aagagcaagg tgtgccaaaa gagaagctga ccgggacaat tcagaacgat      660

atactcaagg aatttatggt tcgtaacact tatatattcc cgcccgagcc atccatgaag      720

attattgctg acatctttga gtacacagct aagcacatgc ctaaatttaa cagtatcagt      780

atctctggct atcacatgca ggaggcgggg gcagatgcaa ttcttgaact ggcctacacc      840

ttagcggatg ggttagaata cagcaggacc gggttgcagg ccgggcttac aatcgacgag      900

ttcgcccctc gcctgagctt cttctggggc attggaatga acttttatat ggagatagct      960

aagatgcggg ccgggcgtcg actctgggct cacctcatcg aaaagatgtt tcagcccaag     1020

aattcaaaaa gccttctgct gagagctcac tgccagacat ccggttggtc ccttaccgag     1080

caagacccat acaataacat cgtgcgcacc gcaatcgaag ctatggccgc cgtttttggg     1140

ggcacgcagt ccttacacac aaattcattt gacgaggcgc tcggtctccc cacggtgaaa     1200

tccgcgagga ttgcgcggaa tactcaaatc attattcagg aggagagtgg aatcccgaag     1260

gttgcggatc catggggcgg ttcatatatg atggagtgcc ttacaaatga tgtgtatgac     1320

gcagcactta aattgattaa cgagatcgag gaaatgggcg ggatggccaa ggctgtggcc     1380

gaaggcatcc caaaactgcg gatcgaggaa tgtgctgcta gaaggcaggc tcggatcgac     1440

tcaggaagcg aagtcatcgt gggcgtcaac aaataccagc tagaaaaaga agacgccgtg     1500

gaggtgctcg ccatcgacaa taccagtgta agaaatcgcc agatcgaaaa gcttaaaaaa     1560

attaagtcct cccgggacca ggcgttggcc gaacgctgcc ttgccgctct gaccgagtgt     1620

gccgcatccg gcgatggaaa catactcgca ctcgcagtcg acgccagccg ggctagatgt     1680

accgtaggcg agattacaga tgccctgaag aaagtgttcg gggagcacaa ggccaacgat     1740

cggatggtga gcggcgcata tagacaggag ttcggggaga gcaaggaaat caccagcgcc     1800

atcaaaaggg tgcacaaatt catggagaga gaaggacggc gaccccggtt actggtagct     1860

aaaatgggtc aggatggcca cgaccgaggg gccaaggtga tcgccaccgg atttgccgac     1920

ttggggtttg acgtggacat tggaccccta tttcaaactc cgagagaggt cgcacagcaa     1980

gctgtagatg ccgacgtgca tgccgttggg atctctacac ttgcggcagg acacaagacg     2040

ttggttccgg agcttattaa ggagctgaat tcactgggca gaccagatat tttggtcatg     2100

tgcggtgggg tgataccccc ccaggactac gagttcttgt tcgaggtcgg agtgtccaac     2160

gtgtttggac ctggcacacg catacccaag gcagctgtgc aggtgctgga tgacattgag     2220

aagtgcctgg agaagaagca gcagtccgtg                                      2250


<210>  118
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I69V mutation

<400>  118
atgctgcgag ccaagaatca gctcttttta ctttcacctc attatctgcg tcaggttaag       60

gaaagctcag gctctagact gattcagcaa aggttactcc accagcaaca acccctgcat      120

ccggagtggg ccgcactggc taagaagcag ttgaagggca agaatccgga agacctcatc      180

tggcacaccc cagaggggat atctgtgaag ccgctttatt ctaaacggga cactatggat      240

ctgccagaag agctgcctgg cgttaagcca ttcacccgcg gaccctatcc caccatgtac      300

acctttagac catggacaat ccgacagtat gcgggcttca gcacagtgga agagtctaat      360

aaattctaca aagataacat aaaggccggc cagcagggcc tctccgtcgc gtttgattta      420

gctacacata gaggctacga ttcagacaac ccaagagtgc gaggcgacgt tggaatggct      480

ggggttgcta ttgatactgt agaggataca aagattctct ttgacggtat accgttggag      540

aaaatgtctg tctccatgac tatgaatggg gccgtgatcc cagtcctggc caacttcata      600

gtgacaggcg aggaacaggg cgttccaaag gaaaagctga ctggaacaat ccaaaacgat      660

attctgaaag agttcatggt ccggaacact tatattttcc cacccgaacc ctcaatgaag      720

atcatcgcag atatattcga atatactgca aaacacatgc ccaaatttaa ttccatctct      780

atcagtggat accacatgca ggaggccggc gcggacgcta tactggagtt agcctacacg      840

ctcgccgacg gcctggagta tagccggacc ggtctccagg ctggtctgac tattgatgag      900

ttcgccccac ggctgtcctt tttttggggc attgggatga acttctacat ggaaatcgca      960

aagatgcgag caggaaggcg tctgtgggcc cacttaattg agaagatgtt ccagcccaag     1020

aattcaaagt cacttcttct gcgggcacac tgccagacgt ccggctggtc cctgacagag     1080

caggatcctt acaacaatat cgttagaaca gctattgagg ctatggctgc tgtgttcgga     1140

ggcacccagt ctctgcacac taactccttt gatgaggcac tgggacttcc gactgttaag     1200

tccgccagaa tagcgaggaa tacccagatt atcatccaag aagaaagtgg tatccctaaa     1260

gtggcggacc catggggggg gtcttacatg atggaatgtt taaccaatga cgtgtatgat     1320

gccgccttga agctaatcaa tgagattgag gagatgggag gcatggccaa ggctgtggca     1380

gaaggaattc ccaagctccg gatagaggag tgtgccgcta gaagacaagc ccgaatagat     1440

agcgggtctg aagtcattgt aggggtgaac aaataccagt tggagaaaga ggacgcagtg     1500

gaggtactcg ccatcgataa tactagcgtc cggaaccgac aaattgaaaa gctcaagaag     1560

atcaaatcta gtagggacca ggccctcgcg gaacggtgtc tggcagcact gacagagtgc     1620

gccgccagtg gagacggtaa tatcctggct ctggcggtcg acgcaagtag ggctcggtgc     1680

actgtgggcg aaattaccga cgcgcttaaa aaggtgttcg gggagcacaa agctaacgat     1740

agaatggtga gcggagcata tcgtcaagaa ttcggcgaat caaaggaaat tacttctgca     1800

attaaaagag tacataagtt tatggagagg gaaggacgcc gccccagact gctggtggcc     1860

aaaatgggac aagatggaca cgatcgaggt gccaaagtca ttgccacagg atttgcggac     1920

ctaggattcg acgtggatat tggcccactg ttccagacgc cgagggaagt ggcccaacag     1980

gcagtagacg ccgatgtaca tgccgtggga ataagcaccc tggctgctgg ccataaaact     2040

ctggtgcctg agctaatcaa agagctgaac tctttgggac gaccggatat attagtcatg     2100

tgtgggggtg tcattcctcc ccaggactac gagttcctct tcgaggtagg ggtgtctaac     2160

gtctttggcc ccggcactcg tattcctaag gcagccgtac aggtgctcga cgatatcgag     2220

aagtgcttgg agaagaaaca gcagtctgtg                                      2250


<210>  119
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I69V mutation

<400>  119
atgttgcggg ctaagaacca gctgttcctc ctcagccctc attacttgcg tcaggtcaag       60

gaatctagcg ggtcgcgcct tattcagcag agactgcttc accaacagca gcccttgcat      120

ccggaatggg ccgccctcgc gaaaaaacaa ctgaagggca aaaaccccga ggacttaatc      180

tggcacaccc ctgaaggcat ctccgtgaaa ccactctatt caaaacgaga cacaatggac      240

ttgccggagg agctcccggg cgtgaagcca ttcactaggg gaccatatcc aacgatgtac      300

acgttcagac cctggacgat ccggcagtat gcaggtttct ccacagtcga ggagtcaaac      360

aaattttata aggataacat aaaggccggt cagcaggggc tcagcgtggc ttttgacctg      420

gctacccata ggggatacga ctccgataat ccacgcgtcc gtggcgacgt gggcatggcc      480

ggagttgcca tcgatacagt cgaggacacc aaaatactct ttgacggaat cccgctggaa      540

aagatgtccg tttctatgac tatgaatggg gcggttattc cagtgctcgc aaatttcatt      600

gtaactggtg aggaacaagg agtgcctaag gagaaactaa ctggcactat acaaaacgac      660

atcctgaagg agtttatggt gcgaaacaca tacatctttc ctccagaacc ctccatgaag      720

attatcgccg atatttttga gtacactgcg aagcatatgc cgaagtttaa ctccatctcc      780

atcagtggtt accacatgca ggaggccgga gccgacgcta tccttgagct cgcctacacg      840

ctggctgacg gcctggagta cagccgcact ggtctccagg ctggattaac gattgacgaa      900

tttgctccac ggctgtcttt tttttggggg atcgggatga acttctacat ggaaatcgct      960

aagatgcggg ctgggcgccg gctctgggct catctaatag agaaaatgtt ccaacctaag     1020

aattcgaaat ctctccttct ccgggcacac tgtcagacaa gcggatggag cctgaccgaa     1080

caggaccctt acaacaacat cgtccgtact gcaattgagg ctatggccgc tgtgttcggt     1140

gggactcagt cgttacatac aaattccttt gatgaggccc tcggactccc caccgtgaag     1200

agcgctcgga tcgctcgcaa tactcaaatt attatacagg aagagagcgg tatcccaaaa     1260

gttgccgatc catggggggg gagttatatg atggaatgct taacaaacga tgtgtacgat     1320

gctgctctta agctgatcaa cgaaatcgag gagatgggcg ggatggcaaa agcagtagcc     1380

gagggaattc caaaactacg cattgaggag tgtgccgctc ggcggcaagc taggattgac     1440

tctggttcag aggtgattgt cggagtgaat aaataccagc tcgagaaaga agatgcggtg     1500

gaggtgctcg ccatcgacaa tacaagcgta cggaatagac agatagagaa gttgaagaaa     1560

attaagtcaa gtcgggatca ggcactcgct gagcggtgcc tcgctgctct cactgagtgt     1620

gctgcctctg gagatggaaa tatcctggct cttgcagtgg acgcctcccg ggctaggtgc     1680

actgtgggtg aaataactga tgctctaaag aaggtctttg gcgagcacaa agctaatgat     1740

cgcatggtat caggcgccta tagacaggaa ttcggtgagt caaaggaaat aacctccgct     1800

ataaagagag ttcacaaatt catggagcgt gagggacgaa ggcctcgact cctcgtggcg     1860

aaaatggggc aggatggcca cgaccgaggc gccaaggtaa ttgccactgg tttcgcagac     1920

ctgggcttcg acgtcgacat aggtcccctg tttcaaaccc ctagagaggt cgcccaacag     1980

gccgtggacg ctgatgtaca cgcggtcgga atcagcactt tggcagccgg gcataagact     2040

ctcgttccag aacttatcaa agaattgaat tcgctgggca ggcccgatat tctcgtcatg     2100

tgtggtggtg tcattccgcc acaggattat gagtttttat tcgaagtggg agtctccaac     2160

gtgttcgggc ctgggacgag gatccccaag gctgccgtac aggtgctgga cgacatcgag     2220

aagtgtctag agaaaaagca acagtcagtt                                      2250


<210>  120
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I69V mutation

<400>  120
atgctgcgtg cgaaaaatca actgttcctg ttgtcccctc actacctccg tcaagtgaaa       60

gaaagttctg gctctcgact catccagcaa cgattactcc accaacagca gccacttcac      120

ccagagtggg ccgccctggc caagaaacag ctcaaaggga aaaatccgga ggatctgatt      180

tggcacacgc ctgaaggcat aagcgtgaaa cctctgtact cgaagcggga caccatggac      240

ctgccggagg agctgccagg agtcaagcct tttactcgtg gcccataccc tacgatgtat      300

acatttcgtc cctggacaat tcgccaatac gccgggtttt caaccgtgga ggagagcaat      360

aaattctaca aggataatat taaggctggt cagcaggggc ttagcgtagc attcgatctg      420

gctacacacc ggggatatga ttccgataac cctagagtgc gaggggacgt cggcatggca      480

ggtgtcgcga ttgataccgt ggaggatacg aaaatcctgt tcgatggcat ccctttagag      540

aaaatgtcgg tctcaatgac catgaatgga gctgtgattc cggtgctcgc taatttcatt      600

gttaccggtg aggaacaggg ggtgcccaaa gagaagctca caggaactat tcagaacgac      660

attctgaagg agtttatggt tcgcaataca tacattttcc cccccgagcc aagcatgaag      720

atcatcgccg atatcttcga gtacacggct aagcatatgc ctaagtttaa ctccatatcc      780

atatccggct accatatgca agaagccggc gctgatgcta tcctcgagtt ggcctacacc      840

ctggccgacg ggctggagta ttccagaaca ggcttgcagg cgggtctcac gatcgacgag      900

tttgcgcccc gtttaagctt tttttggggc atcgggatga acttctatat ggaaatagcc      960

aaaatgcggg ctggtagacg tctgtgggct cacctgatcg agaaaatgtt ccagcccaaa     1020

aattccaaga gtttgttact gcgcgcccat tgtcagacaa gcggttggtc tttaacggaa     1080

caagatccat acaacaatat tgtgcgcacc gcgatagaag caatggcagc cgtgttcggg     1140

ggcacacagt ctttgcacac aaactcattc gacgaggccc tgggcctgcc cactgtcaag     1200

tccgctcgta ttgcacgcaa cacccagatt ataatacagg aagaatctgg catacctaag     1260

gtcgctgatc cctggggagg ctcctatatg atggaatgtc tgacaaacga cgtgtatgac     1320

gcagccttga aacttattaa tgaaatcgaa gagatgggag gtatggctaa ggccgtggcc     1380

gagggaattc caaagctcag aatagaagag tgtgccgcca ggcgacaggc taggatagat     1440

agcgggagcg aggtcatagt cggggttaac aagtaccagc tggaaaagga ggatgccgtg     1500

gaggtcctgg ccatcgataa tacttcagta agaaatagac agatagagaa gctgaaaaag     1560

atcaagagtt ctcgtgacca agcactggcc gagcgctgcc tggctgccct gaccgaatgc     1620

gctgcctccg gagatggcaa tattctggcg cttgccgtgg acgcatcaag ggcccggtgc     1680

acagtaggcg aaattaccga tgcactgaag aaggtatttg gggaacacaa agccaatgat     1740

cgaatggtct caggggctta caggcaagag ttcggagagt ccaaagagat aacatctgcc     1800

attaagcgtg tccacaagtt tatggaacgg gaaggcagac gtcctaggtt gcttgtggcc     1860

aagatgggtc aggacggcca cgataggggg gcaaaagtta ttgccacggg cttcgccgat     1920

ctcggcttcg atgtcgacat cggacccttg ttccagaccc ctagggaagt ggctcagcag     1980

gccgtcgacg cagatgtgca tgccgttggt atttcaaccc tggccgccgg tcataagacc     2040

ctagtgccag agctcatcaa agagctcaac agcctgggta ggccggatat cctagtgatg     2100

tgtggaggag tgattccccc tcaggactac gagtttctgt ttgaggtcgg ggtctctaac     2160

gtcttcgggc caggcactag gatcccaaaa gcagctgtgc aggttcttga cgacattgaa     2220

aagtgcctag aaaaaaagca gcagagtgtc                                      2250


<210>  121
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       A499T mutation

<400>  121
atgctgagag cgaagaacca actgtttctg ctcagccccc actacctgcg acaggtgaag       60

gagtcttccg gttcaagact gattcagcag cgcctcctgc atcaacaaca acctctgcat      120

cctgaatggg ctgcgttagc caagaagcaa ttgaaaggca agaatccaga ggaccttatt      180

tggcacactc ctgagggaat ttccattaaa ccgttgtact ctaagaggga caccatggac      240

ttacctgagg aactgcctgg cgttaagccc tttacccgcg gaccctatcc gacaatgtat      300

acctttcggc cttggactat tcgccagtat gccggattca gcaccgttga ggaaagcaac      360

aagttctaca aagataacat taaggcaggc caacaggggc tttctgtggc ttttgacctc      420

gccacccacc gaggttatga ctcagacaac ccaagagtga ggggtgatgt tgggatggcc      480

ggagtggcta tcgataccgt agaagacaca aaaatattgt tcgacggaat cccgctagag      540

aagatgtctg tctctatgac tatgaatggg gctgtcatac ctgttctggc taattttata      600

gttacaggcg aagagcaagg agtacctaag gagaagctca caggcactat ccagaacgat      660

atccttaagg agtttatggt ccgcaacaca tatattttcc ccccagaacc ttcaatgaag      720

ataattgcgg acattttcga gtacactgcc aaacatatgc caaaattcaa ctccatctca      780

atctctgggt atcacatgca agaagctggc gccgacgcca tcctggagct cgcttataca      840

ctggccgacg gactcgaata ctcccgcacc ggactgcagg ctggccttac tatcgacgaa      900

ttcgctccaa ggctgtcatt tttttggggc atcggcatga atttttatat ggaaatcgct      960

aaaatgagag ccgggagacg tctctgggca cacttaatcg agaagatgtt ccaaccaaaa     1020

aattcaaaga gcttgctctt aagagcgcat tgtcagacca gcggatggag tttgacagag     1080

caggacccct ataacaatat cgtccgaacc gccattgaag ccatggctgc agtcttcggt     1140

ggcacgcagt cattgcatac caactcattc gacgaggccc taggtcttcc tacagtgaaa     1200

agcgcccgga tcgctcgaaa cactcagatt atcatccagg aggaaagcgg cattcctaaa     1260

gtggccgacc cgtggggcgg cagctacatg atggagtgcc tgacaaacga tgtgtacgat     1320

gctgcactta agttgatcaa cgaaattgaa gagatggggg gtatggccaa ggcagtggca     1380

gagggtatcc caaagctccg gatcgaagaa tgcgccgcca ggagacaggc tcgtatcgat     1440

agcgggagtg aggttatcgt tggcgtgaac aaataccaac tggaaaagga ggataccgtg     1500

gaggtgttgg ccattgacaa cacctcggtg agaaacagac aaatcgagaa gctcaaaaaa     1560

atcaaatcta gcagagatca ggctctggcc gagcggtgtc tcgctgccct gactgagtgt     1620

gcggcaagcg gcgatggtaa catcctcgcc ttggcggtcg acgcctcccg cgccagatgc     1680

acggtgggcg agattaccga cgctctgaag aaggtcttcg gcgagcataa ggcaaacgac     1740

cggatggtca gcggagcgta cagacaagag ttcggggagt ctaaagagat tacttcagcg     1800

atcaagcgcg tacacaaatt tatggagagg gagggccgcc gtcccaggct tttagtggct     1860

aagatggggc aagatggtca cgacaggggg gctaaggtca ttgcgactgg gtttgccgac     1920

ctaggctttg atgtggacat aggccccctg ttccaaactc ccagagaggt ggcccaacag     1980

gcggtagatg cggacgtaca cgctgtaggc attagcacac tggcagcagg tcacaagacg     2040

cttgttcccg agctgattaa ggaattgaat tctttaggaa gacctgatat actcgttatg     2100

tgcgggggcg tgattccgcc ccaggactat gagttcctct tcgaggtggg ggtgtctaac     2160

gtctttggac ccggcacacg gatcccaaaa gccgcggtgc aagtgttaga cgacattgaa     2220

aagtgtctgg agaaaaagca gcaatccgtg                                      2250


<210>  122
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       A499T mutation

<400>  122
atgctgcgtg ctaaaaatca actgttcctg ctgagcccac actacctaag acaggtgaag       60

gagtccagcg ggtcaagact gattcagcag cgccttttac accagcaaca gcctctgcac      120

cccgagtggg ctgccctcgc caaaaaacag ttgaagggca aaaacccaga agatctaatt      180

tggcataccc ccgaaggcat tagcatcaaa ccactgtaca gcaaacggga tacgatggat      240

ttgccagagg agctgccggg ggtgaagccc ttcacacgcg ggccttaccc aaccatgtac      300

acattcagac cctggaccat ccggcagtat gcaggcttca gcaccgttga ggagagcaat      360

aagttctaca aggataatat caaggcaggt cagcagggac tgtctgtggc ctttgacctg      420

gccactcatc gtgggtatga ctccgataat ccacgggtac gtggtgacgt tggcatggcc      480

ggtgtcgcaa tcgataccgt ggaagatact aagatcctgt tcgatggtat acccctcgaa      540

aaaatgagcg tgtcaatgac catgaatggg gccgtcattc cagtgctggc aaactttatt      600

gttacaggag aagaacaggg agtgcccaag gaaaaactca ccggcactat ccaaaacgat      660

atcctcaagg agtttatggt gagaaatact tatatttttc cacccgaacc aagcatgaaa      720

attattgccg atatcttcga gtataccgcc aagcatatgc cgaaattcaa ctcgatctca      780

ataagcggct accacatgca ggaggctgga gcagatgcta tactcgaact cgcgtatact      840

cttgcggatg gcctagagta cagtcggacc ggtctgcagg ccggattgac tatagacgag      900

tttgcgcctc gtttgagctt cttttggggg attggcatga acttctatat ggagatcgca      960

aagatgcgtg ccggccgccg gctgtgggcc catctgattg agaagatgtt tcaaccgaaa     1020

aacagcaaaa gcctcttatt aagggcccac tgccaaacct ctggctggtc cctgacagaa     1080

caggacccat acaataacat cgtcaggact gctattgagg ctatggctgc agtgttcggt     1140

ggaacgcaat ccctgcatac taactccttc gacgaggctc tcggccttcc aacagtcaag     1200

agcgctagga tagctcgaaa tactcagatt ataattcagg aagaaagtgg tatcccgaag     1260

gtggcagacc catggggagg atcctacatg atggaatgtt taactaacga tgtctacgac     1320

gcagctctga aattgatcaa tgagattgag gagatggggg ggatggcgaa ggctgtggcg     1380

gagggaatcc ccaaactcag gattgaagaa tgtgcggctc gaagacaagc tcggatcgac     1440

agcggaagcg aggtgattgt gggtgtaaac aagtatcagc tagaaaagga agacacagtc     1500

gaggtactgg ccatagataa tacctcggtt cgcaaccggc agattgaaaa gctgaaaaaa     1560

atcaaatcct caagggatca ggcattggcg gaaaggtgtc tggctgccct taccgagtgt     1620

gccgcatcag gagatggcaa tatcctggcc ttggcagttg atgccagtcg agctaggtgc     1680

acggttgggg agatcaccga cgcgctgaaa aaagtctttg gagaacataa ggccaatgat     1740

cggatggtgt ccggagccta cagacaggag ttcggggaat ctaaggagat tacaagcgct     1800

atcaaacggg ttcacaagtt catggagcga gagggacgta ggccacgtct tctcgtggcc     1860

aaaatgggcc aggacggcca tgatcgcggg gcaaaggtga ttgctacagg tttcgctgac     1920

ctcggctttg atgtagatat tggaccgctt ttccaaacac ctcgagaggt cgcccagcag     1980

gccgtagacg ctgacgttca tgctgttggc atcagtacac ttgcagctgg tcataaaact     2040

ttggtgccag agctgatcaa agaactgaat tccctaggcc gccctgacat cttagtcatg     2100

tgtggaggag tgattcctcc acaggactat gagttcctct ttgaggtggg agtatccaac     2160

gtctttggac ccggcacaag aatccccaaa gcggccgtgc aagtgctcga tgatattgag     2220

aaatgcctgg agaagaagca gcaatctgtt                                      2250


<210>  123
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       A499T mutation

<400>  123
atgctgcgcg caaagaacca actcttcttg ctgagccctc actacctgag gcaggtgaaa       60

gaaagctcag gatcgcggct gatccagcag cggctcctgc accagcaaca acccctgcat      120

ccagaatggg ctgcacttgc caaaaagcaa ctcaagggaa agaatccaga ggacttgatt      180

tggcacaccc cagaaggaat ttcaatcaag cccctgtatt ctaaacggga caccatggat      240

cttccagagg aactgcctgg ggtcaaaccc tttaccagag ggccctatcc aaccatgtat      300

acattccgcc catggacaat cagacagtat gcaggattca gtaccgtgga agaaagtaac      360

aagttctata aggataacat taaggcaggc cagcagggat taagtgttgc ttttgatctc      420

gctacccacc gagggtacga ttctgacaat ccgcgagtcc gtggtgacgt cggcatggcc      480

ggtgttgcaa ttgatactgt tgaggacacg aaaattctgt ttgacggaat ccctctcgaa      540

aagatgagcg tttctatgac tatgaatggc gctgttatcc ctgttctggc taacttcatc      600

gtgacgggag aggagcaggg cgtccccaag gagaaactga caggcacaat tcagaacgat      660

atactgaaag aattcatggt gcgtaacacc tatattttcc caccggagcc ttccatgaaa      720

atcatcgctg acatctttga atatacagcc aagcatatgc cgaagttcaa ctcaatttcc      780

atctcaggct accatatgca ggaggcaggc gcagacgcaa tattggagtt ggcctatacc      840

ctggcagatg ggttagaata ttcccgaacg ggactgcaag ctggactgac catcgatgag      900

tttgcccctc gcctttcctt tttctgggga ataggaatga acttctacat ggagattgcg      960

aaaatgcgcg ccggtcgccg attgtgggct cacctgatcg agaagatgtt tcagcctaaa     1020

aatagcaaat ctttgctcct gagagcccac tgccagacct ctgggtggtc tctgaccgaa     1080

caggacccct ataataacat agtgcgtacg gctattgaag ctatggctgc agtcttcggc     1140

gggacacagt ctctgcatac caactctttc gacgaggcgc tcggactgcc caccgtgaag     1200

agcgccagaa tcgccagaaa tacccaaatc ataatccagg aagaatctgg aattccaaaa     1260

gtggcagacc cgtggggcgg ttcctacatg atggagtgtt tgacaaatga tgtgtacgac     1320

gcagccctga agttgatcaa tgaaattgag gaaatgggcg ggatggccaa ggcggtcgct     1380

gaaggaatcc ctaagctgcg tatcgaggaa tgcgccgccc gacgacaggc gcgcattgac     1440

agcggctctg aggtaatcgt gggtgtcaac aagtaccagc tggagaagga agatactgtc     1500

gaggtcctgg ccattgacaa tacctcggtt agaaacaggc aaatcgagaa gctgaaaaaa     1560

atcaagagta gccgtgacca ggctttggct gaaaggtgcc tggctgcttt gaccgagtgc     1620

gctgccagcg gcgatggcaa tatactcgcc ctagctgtgg acgcatcacg ggctcgatgt     1680

acagtgggcg agattacgga tgcactgaaa aaggtgtttg gtgagcacaa ggctaatgac     1740

cgcatggtgt ccggcgccta ccgacaggag tttggagagt ccaaagaaat caccagcgcc     1800

atcaagaggg ttcacaagtt catggagcgg gagggcagac ggccccggct tcttgtggcc     1860

aagatgggcc aggatggaca cgatcgggga gctaaagtca tcgctacggg tttcgcagat     1920

ttagggtttg atgtggacat cggcccactg ttccaaactc ccagagaggt ggcccagcaa     1980

gcggtagatg ctgacgtgca cgcagtgggt atttctaccc tggccgccgg acacaaaact     2040

ctggtgcccg aattgataaa agagcttaat tctcttggac gacctgatat ccttgttatg     2100

tgcggtggtg tgatcccccc tcaagactac gagttcttgt tcgaggtcgg agttagcaat     2160

gtcttcgggc cgggcacacg gatacccaaa gctgcagtgc aagtactaga tgatattgaa     2220

aaatgcctgg aaaaaaagca acagagtgtg                                      2250


<210>  124
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       A499T mutation

<400>  124
atgctgaggg ccaaaaatca gttgttcttg ctgagtcccc attaccttcg tcaggtcaag       60

gaaagcagtg ggtctcgtct gatccagcaa aggctgctgc atcaacagca gcctctgcac      120

cctgagtggg cagcactcgc taagaagcag ctgaaaggca aaaatccgga agacctaatc      180

tggcatactc ccgaaggcat atctatcaaa cctttgtata gtaagcgtga cacaatggat      240

ctgcctgaag agctgccggg agtcaagcct tttactaggg gcccttaccc tacaatgtac      300

actttcaggc cctggacaat aaggcaatac gctggcttta gtacagtcga ggagagcaat      360

aaattttata aagataacat caaggctgga cagcaaggcc tgtctgtggc ctttgactta      420

gctactcata gaggttatga cagcgataat ccgcgggtgc gtggcgacgt gggaatggcc      480

ggagtggcca tcgacaccgt agaagacact aagattctgt tcgatggaat ccctctggaa      540

aagatgtccg tctcgatgac catgaatggg gccgtcatcc ccgtactagc aaacttcatc      600

gtcactggtg aggaacaagg cgtcccgaag gaaaaactga caggcacaat ccagaacgac      660

atcctcaaag aatttatggt ccgaaatacc tatattttcc ctcccgaacc cagtatgaag      720

attattgccg atatattcga atataccgcc aagcacatgc ccaaattcaa ttccatttcc      780

atttcggggt accatatgca ggaagctggc gcggatgcca tccttgaatt ggcctacact      840

ctcgctgatg ggctcgaata ttctagaacc gggctgcagg ccggattgac aatcgatgag      900

tttgccccac gcctgtcttt cttctggggt attggtatga acttttatat ggagatcgct      960

aaaatgcggg ccggcaggcg gctctgggcg cacctgatcg agaagatgtt tcagccgaag     1020

aattctaaga gcctgctgct gagggctcac tgtcagacat caggttggtc cctgacggag     1080

caggacccat acaataatat tgttcgaaca gccattgagg ccatggcagc tgtgtttggc     1140

gggacgcagt ccctacatac taattcgttc gacgaagcgt taggtctccc tacagtcaag     1200

tctgccagaa tagcccgcaa tacccaaatc attatccagg aagagagcgg catcccaaag     1260

gtagcggacc cctggggagg aagctacatg atggaatgcc tgaccaacga cgtgtatgac     1320

gctgctctga agctgattaa tgagattgaa gaaatggggg gcatggcaaa agccgtcgcc     1380

gagggtatcc ctaagcttag aatagaggag tgtgctgcac gccgccaagc acggatagat     1440

tcaggatcag aggtcatagt cggcgttaac aaataccagt tagagaagga ggacacagtg     1500

gaagtgctag cgattgataa tacttccgtg agaaacagac agattgagaa actgaaaaaa     1560

attaagtcta gccgggatca ggccctggct gaaaggtgtc tggcggctct aactgagtgc     1620

gcggccagtg gagacgggaa tattcttgct ttagctgtcg acgcttcgcg ggctaggtgc     1680

acagtgggtg aaattaccga tgcattaaaa aaagtgtttg gggaacataa ggcgaacgac     1740

cgcatggtga gcggtgctta ccgtcaggag tttggggagt caaaggagat cacatccgct     1800

atcaagaggg tgcataagtt catggagcgg gaggggcgga ggccaagact gttagtagca     1860

aaaatggggc aggacggtca tgataggggt gctaaggtta ttgcgaccgg gttcgcagac     1920

ctgggtttcg acgttgatat cggaccttta ttccagaccc ctagagaggt ggcccagcaa     1980

gctgttgatg ctgacgtgca tgctgtgggc atctcaactc tcgccgcggg ccacaagaca     2040

ctggttcccg agctgatcaa agagttgaac tcactggggc ggcctgacat tctggtcatg     2100

tgtggaggag tgatcccgcc ccaggattac gaatttctgt tcgaggtggg tgttagtaac     2160

gtgtttggac ctggaaccag gattcccaag gcggccgtcc aggtcctgga cgacatcgag     2220

aagtgcttgg agaagaagca gcaatccgtg                                      2250


<210>  125
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       A499T mutation

<400>  125
atgctgaggg ccaagaacca gcttttcctc ctgtcacctc actacttaag acaagtgaaa       60

gaatcctcag gttctaggct gattcagcag cgcttgctgc atcagcaaca gcctctccac      120

cctgagtggg ctgctctggc taaaaaacaa ttgaaaggta agaaccccga agatctcatc      180

tggcatactc ctgaaggaat tagcataaag ccgctgtact ccaagcgaga cacaatggat      240

ctgcccgagg agttgcctgg agttaagcca tttaccaggg gtccgtatcc gaccatgtac      300

accttcagac cctggacaat caggcagtac gctgggttct ctaccgtcga ggagtccaat      360

aaattttaca aagacaacat caaagctggc caacagggac tgtctgtagc cttcgatctg      420

gccacccata ggggctacga ttccgataat cccagggtca ggggggacgt gggcatggcc      480

ggcgtggcca tcgacaccgt agaagatacc aagatcctct ttgatggaat tcccctcgag      540

aagatgtcag tgagcatgac aatgaacggg gctgtaatcc ctgtcctcgc aaactttatc      600

gtgacgggag aggagcaggg cgtgcccaag gaaaaattga caggaaccat acagaatgat      660

atcttgaagg aattcatggt gcggaatacc tacatatttc ctccagaacc gtcaatgaaa      720

attatagccg atatcttcga gtacactgcc aagcacatgc ctaaattcaa ttccatcagc      780

atcagcgggt accatatgca ggaagccggg gccgatgcta tcctggaact ggcctacact      840

ctggccgacg gactggagta tagtcggacc ggattgcaag ccggactgac tattgatgaa      900

ttcgccccta gattatcctt tttctgggga attggaatga acttttatat ggaaattgct      960

aagatgcgcg cagggaggcg gctgtgggcc cacttaattg agaaaatgtt ccagcccaag     1020

aatagtaaat cgcttctcct tcgagcccac tgccagacca gcggttggtc actgactgag     1080

caggaccctt ataacaatat tgttaggaca gcaatagaag cgatggctgc agtgtttgga     1140

ggcactcaat cattacatac caattccttc gacgaagcac tggggctgcc aaccgttaag     1200

agcgctagaa tcgcacgcaa cacgcagatc atcattcagg aagagtcagg aattcctaag     1260

gtggctgatc cttggggcgg aagttacatg atggagtgtc tcacaaatga tgtgtatgat     1320

gcagctttaa agcttataaa cgagattgag gaaatgggcg gcatggccaa agcagtggca     1380

gagggtatcc caaagctccg catcgaggaa tgtgctgcac gccggcaggc tcgcattgat     1440

tcaggctccg aagtgattgt gggagtgaac aagtatcagc tcgaaaaaga ggatacagtg     1500

gaggtgctgg ccattgataa caccagcgtc cggaatagac aaatcgagaa actgaaaaaa     1560

atcaagtcta gcagggatca ggcactcgcc gaaagatgtt tagccgccct gaccgaatgt     1620

gccgctagcg gtgacggcaa cattttggcc ttggccgtgg acgcctcacg cgcaaggtgt     1680

acggttggtg aaatcaccga cgctctcaaa aaagtcttcg gagaacacaa agctaatgac     1740

cggatggtgt ctggcgccta ccggcaggag ttcggcgaat ccaaggaaat aaccagtgct     1800

ataaaacggg tgcacaagtt tatggagagg gaaggtagga ggcctcgctt actggtcgct     1860

aagatgggac aagacggaca cgaccgcggc gccaaagtca tcgccacagg attcgcagat     1920

cttggctttg acgtcgacat aggaccgctg tttcaaactc caagggaggt tgctcagcaa     1980

gcggtagatg cagatgtgca cgctgtcggc atatccacct tagctgcagg tcacaaaacc     2040

ctggtgccgg agttgataaa ggagctcaat tccttaggga ggcccgatat attggtcatg     2100

tgcggtggcg tgataccacc ccaggactac gagttcctct tcgaggtggg tgtcagtaac     2160

gtcttcggtc ccggcacaag aatcccaaag gctgctgtac aggttctaga cgatattgag     2220

aaatgcctgg agaaaaagca gcaatccgtg                                      2250


<210>  126
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       A499T mutation

<400>  126
atgcttcgcg ccaaaaatca gctgttttta ctgagtccgc actatcttag gcaagtcaaa       60

gaaagctccg gctcacgact gattcagcag cggctcttac atcagcaaca acctctgcat      120

cctgaatggg ctgccctcgc caagaagcaa cttaaaggaa agaatcccga ggacctcatc      180

tggcacactc cagagggcat ctctattaaa cccctgtact ccaagcgtga cacgatggat      240

ctcccagagg agctgcctgg agttaagccg ttcacccgtg gcccctaccc aaccatgtac      300

acctttaggc cttggaccat tagacagtac gccggtttta gcacagttga agagagcaac      360

aagttctata aggacaacat caaagctggg caacagggac tgtctgtggc cttcgatctg      420

gccactcacc gaggttacga tagcgacaat cctcgggtga ggggagatgt gggaatggct      480

ggggtggcaa ttgacactgt tgaggataca aagatcctat tcgacggtat accactggaa      540

aagatgtcgg tttctatgac gatgaatgga gcagtaattc ctgtgttggc caactttatc      600

gttacggggg aggaacaggg cgttccgaag gaaaagctaa caggtaccat ccagaacgat      660

attcttaagg agttcatggt gcgcaacact tacatatttc cacctgagcc atccatgaag      720

attatagctg atatattcga atacaccgcc aagcatatgc ctaaattcaa ttccatctca      780

atcagtgggt atcatatgca ggaggccggc gcggacgcaa ttcttgagct cgcctataca      840

ttggcggacg gtttagaata tagccggacc ggcttacagg ccggcctgac cattgatgaa      900

ttcgcccctc ggttgtcttt cttctgggga atcggtatga acttttatat ggagatcgca      960

aaaatgagag cgggccggcg tctgtgggca catttgatag aaaaaatgtt tcaaccaaaa     1020

aacagcaaaa gcctgcttct gcgagcccac tgtcagacaa gcggttggtc tctcactgag     1080

caggacccat acaataatat agtgcgaaca gctatcgagg ccatggccgc cgtgtttggt     1140

ggcacacaat ctctgcatac caacagtttt gacgaggccc tgggtctgcc aactgtgaaa     1200

agcgccagga tagcccgcaa tacccagatc ataatccaag aagaatctgg cattcctaaa     1260

gtggcagatc cttggggagg aagttatatg atggaatgtc tgacaaacga tgtctatgac     1320

gccgctttga agctaatcaa tgagatagag gaaatgggcg ggatggcaaa agccgtcgca     1380

gagggcatcc ccaagctgcg gatcgaagaa tgtgctgctc gacgtcaggc tcgaattgac     1440

tcaggatccg aggtaatcgt gggcgtaaac aaataccagc ttgagaaaga ggacaccgtc     1500

gaagtgctgg ccatcgataa caccagcgtc aggaaccgtc agattgagaa gctaaagaag     1560

ataaagagta gtcgcgatca ggccctggcc gagaggtgcc tggcagccct tactgagtgt     1620

gccgcaagtg gggacggcaa catcttagca ctcgccgtcg atgctagcag ggccagatgt     1680

accgtcgggg aaattaccga tgccctcaag aaagtgttcg gagaacacaa agccaacgat     1740

cggatggtca gcggggcata ccgccaggag ttcggcgaga gtaaagaaat cacctctgcc     1800

atcaaaaggg tccataagtt catggagagg gagggaaggc gcccccgttt gttagtagcc     1860

aagatgggcc aagatggcca cgaccgagga gccaaggtga ttgcaaccgg gttcgcagat     1920

cttggcttcg acgtcgatat cggcccccta tttcagaccc ctagggaggt ggcacaacaa     1980

gcagtggacg cagacgtgca tgctgtgggg atctcaaccc tggcagccgg acataagacc     2040

ttggtgccgg aactgataaa ggagctgaat tctttgggca ggccagacat cctggtgatg     2100

tgtggcggag taataccccc gcaggattac gagttcctgt tcgaggtggg cgtctccaat     2160

gtgttcgggc caggtacgcg cattcccaaa gccgctgtgc aggtgctcga cgatatagag     2220

aagtgtctgg aaaaaaagca gcaatccgtc                                      2250


<210>  127
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       A499T mutation

<400>  127
atgctccgcg caaagaatca actgttcctg ctctcgccac actacttacg ccaggtcaag       60

gagagctccg ggtcccggct tatccaacag cgtctgctgc atcagcagca gcccctacac      120

cccgaatggg cagctctggc aaagaagcaa cttaaaggga agaacccgga agacctaatc      180

tggcacaccc cagaaggtat tagcatcaag ccattgtact ccaaaagaga cactatggat      240

ctcccagagg agctgcccgg ggttaagcca ttcactagag gaccttatcc aacaatgtac      300

acctttaggc cctggaccat tagacagtat gctggttttt caacagtcga ggagtctaac      360

aaattttaca aggataatat taaagccggg cagcaggggc tatccgttgc ctttgatctt      420

gccacccatc gcgggtacga cagtgataat ccccgcgtgc gtggagacgt gggtatggcc      480

ggggttgcga ttgatacggt tgaagatacc aaaatccttt tcgacgggat tcctcttgaa      540

aaaatgtctg tctcaatgac tatgaatggc gcagtgatcc ctgtactggc aaatttcata      600

gtgaccgggg aggaacaggg tgtgcccaaa gaaaagttaa cgggcacgat acagaatgac      660

attctaaaag aattcatggt ccggaatacg tatatcttcc ccccagaacc ttccatgaaa      720

attatcgcag atatctttga atacaccgcc aagcatatgc ccaaattcaa ttccatctcc      780

atctcgggct atcacatgca agaggcaggg gccgatgcta tccttgaact cgcttatacc      840

ttggcggacg ggctggaata cagtcggacc ggattacagg ccggactgac aatagacgaa      900

ttcgctccca ggctttcatt cttctggggc attgggatga acttttacat ggaaatcgca      960

aagatgcgag caggccgacg cctctgggct catctgattg aaaagatgtt ccagcccaaa     1020

aacagcaaat ccctcttact gagagcacac tgtcagacca gcgggtggtc gctgactgag     1080

caagatccgt acaataacat agttcgtaca gccatcgagg ccatggctgc agtgtttggt     1140

ggcacccagt ctttgcacac taattcgttt gatgaggccc taggactgcc cacagtaaaa     1200

tccgctagga tcgcacggaa tacccagatt atcattcagg aagagagtgg catcccaaaa     1260

gtggccgatc catggggtgg ctcctacatg atggaatgct tgaccaatga tgtgtatgat     1320

gccgccctga aactaataaa cgaaattgag gagatgggtg ggatggctaa ggcagtggcc     1380

gaaggtatcc cgaaactcag aatagaggag tgcgctgcca ggagacaggc acggattgat     1440

agtggtagcg aggttatcgt gggcgtgaat aaataccagc tggagaaaga ggataccgtg     1500

gaagtcttgg caatcgacaa cacatcggtg cggaatcgcc agatcgagaa gctgaaaaaa     1560

atcaaatcct ctcgcgacca ggcattggcc gagcgatgtc tcgccgcttt aacggaatgc     1620

gcagcaagtg gagatggtaa tatactggct ctggctgttg atgcatctag agcccgctgt     1680

actgtggggg agatcacgga tgcgcttaaa aaagttttcg gcgagcacaa agctaatgac     1740

cgcatggtga gtggtgcata ccgccaagaa tttggagagt caaaagagat cacttcggcc     1800

attaaacgtg ttcataagtt catggaacgc gaaggcagga gaccgcgact gctcgtggcg     1860

aagatgggcc aggatggcca tgaccgggga gcaaaagtta tagcaacagg atttgctgac     1920

ctcggattcg acgtggacat aggccctctc tttcagacgc ctagggaagt cgctcagcag     1980

gccgtggacg cagacgtgca cgcagtgggc atttccacgt tggcggcagg acacaaaacc     2040

ttggtccctg agctcatcaa ggagctgaat tcgctggggc gcccggacat tctagttatg     2100

tgtggtggcg ttatccctcc ccaggactac gagttcctct tcgaagtggg agtatctaac     2160

gtgttcggtc ccggcacccg gatacctaag gcagccgtgc aggtactgga tgacatagag     2220

aagtgtctgg aaaaaaagca gcagtccgtg                                      2250


<210>  128
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       A499T mutation

<400>  128
atgctacgcg caaaaaatca gctgttcctg ttaagtcctc attacttaag gcaggtgaag       60

gaaagtagcg gctcgcgctt aatccagcaa aggctcctgc accagcagca gccgctgcat      120

cctgaatggg ccgctctagc taaaaaacag ctgaagggaa agaaccctga agatctgatt      180

tggcacaccc cagagggaat tagcatcaag ccactgtaca gtaagcgtga tactatggac      240

cttcctgaag aacttcccgg cgtgaagccc tttactaggg gaccttaccc taccatgtat      300

accttcaggc cctggaccat taggcagtat gcaggcttca gcaccgtcga agaatcaaat      360

aagttctaca aggacaacat aaaggcgggc caacagggtc tgagcgtggc cttcgatctg      420

gcaacccata gaggctacga cagcgacaac cctcgagtgc ggggagacgt cggcatggcg      480

ggagtcgcca tcgatacagt ggaagatacg aaaattttgt ttgacggcat tcccctcgaa      540

aagatgagcg tgtcaatgac catgaatggc gccgtcattc cagtactggc caattttatt      600

gttaccgggg aagagcaagg cgtcccaaag gagaaattaa cggggaccat ccagaacgac      660

atcctgaagg agttcatggt cagaaacacg tatatattcc ctcctgagcc aagtatgaag      720

atcattgcag atatcttcga gtacactgcg aagcatatgc caaagttcaa ctcaatctcc      780

atatcaggct atcacatgca ggaagcagga gcagacgcaa tcttggagct ggcctacacc      840

ctggctgacg ggctggagta ctcccgaact ggattgcaag ccggcctgac catagacgag      900

ttcgcacccc gtttgtcctt tttttggggc atcgggatga atttctacat ggagattgct      960

aagatgcgcg caggcaggcg cttgtgggct catctaatag aaaaaatgtt tcaacctaag     1020

aacagtaaat cactcctgct gcgtgcgcac tgccagacaa gcggctggag tcttacagag     1080

caagacccat ataacaatat cgttagaaca gcaattgagg caatggccgc tgtgtttggc     1140

gggacacagt ccctacacac aaacagcttt gatgaggcac tcggcttacc cacagtgaag     1200

tccgcccgca tagctaggaa cacacagatc atcattcagg aagagtccgg catccccaaa     1260

gttgccgacc cttggggcgg ctcctatatg atggaatgtc tcactaacga cgtgtatgac     1320

gctgctctga aattgatcaa tgagatcgag gaaatgggtg gcatggccaa agcagtcgcc     1380

gaaggcatcc cgaagcttcg aatcgaagag tgtgctgcac ggaggcaggc cagaatcgac     1440

agtggttccg aagtgatcgt aggagtgaac aaatatcagc ttgagaaaga agataccgtg     1500

gaagtgctgg ccattgacaa tacctctgtt aggaaccgcc agatagagaa gctcaaaaag     1560

attaagtctt cgcgggatca ggcgcttgcg gagaggtgtt tagcagccct gaccgagtgt     1620

gcggctagtg gggacggcaa catccttgcg ctggcagtgg atgcgagcag agcaagatgt     1680

actgtaggcg aaatcaccga cgccctcaag aaggtgttcg gcgagcacaa ggccaatgac     1740

cgaatggtgt ctggcgcata tagacaagag tttggtgaga gcaaggagat cacatccgca     1800

attaagagag tgcacaagtt catggagcgc gagggaaggc gcccaagatt actggttgca     1860

aaaatggggc aggacgggca cgaccggggc gccaaggtga tcgctactgg cttcgcagac     1920

ctgggctttg acgtcgatat cggacctctg ttccagacac caagagaagt agctcagcag     1980

gccgtggacg ccgatgtgca tgcagtcggt attagtactc tggccgccgg gcacaagaca     2040

ctggtgccag agctgatcaa ggagcttaac tcactggggc ggcctgatat attggtcatg     2100

tgtggcgggg tgatcccacc tcaagattac gagttcctgt tcgaggtggg agtttctaac     2160

gtctttggac ctggtacccg catcccgaaa gccgcggtgc aggtgctgga tgacattgag     2220

aagtgcctcg aaaagaagca gcagagtgtg                                      2250


<210>  129
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       A499T mutation

<400>  129
atgctgaggg ccaagaatca gctgttcctt ctgagccctc attatctgcg gcaggtcaag       60

gagagctcgg gatctcgact gattcagcaa cgcctcctgc accaacagca gcctctacac      120

ccagaatggg ccgccttggc gaagaaacaa ctaaagggaa aaaatcccga agacctcatc      180

tggcacaccc cggaagggat tagcattaaa ccactctaca gtaagcgtga cacgatggac      240

ctgcccgagg agctgccagg ggtgaaaccc ttcaccaggg gcccttatcc cacaatgtat      300

acgtttaggc cctggacaat ccggcagtac gctgggttca gtactgttga agaatctaac      360

aagttctata aggacaacat aaaggcaggg cagcaggggt tgagtgtggc atttgaccta      420

gctactcata gggggtatga ctctgacaat cccagagtaa ggggcgatgt agggatggcg      480

ggggtcgcca ttgatactgt cgaggacacc aagatactgt ttgatggaat cccgctcgaa      540

aagatgagcg tgtccatgac tatgaacggc gcggtgatcc cagtgctggc caacttcatc      600

gtcaccggag aggaacaggg agtgcctaag gaaaagttaa ctggtacgat ccagaacgac      660

attttaaagg aattcatggt caggaatacc tatatattcc cacctgaacc tagcatgaag      720

atcattgcag acatattcga gtacaccgct aagcatatgc ctaagttcaa tagcataagt      780

atcagcggat accacatgca ggaggcaggg gcagacgcca tcttggaact ggcctacaca      840

ctggccgacg gactcgagta ttcgagaacg ggtctgcagg ccggtctgac catcgatgag      900

tttgcgccaa gactgagctt tttttgggga attggcatga acttttatat ggagattgcg      960

aaaatgcggg ccggcaggcg cctctgggcg cacttgatcg agaagatgtt tcagcccaag     1020

aattcaaaga gtctgctcct gagggcccac tgtcagacct cgggatggtc tctcacggag     1080

caggacccat acaataacat cgtcagaacc gccattgaag caatggccgc tgtgttcggg     1140

ggaacgcaga gtcttcatac gaactccttc gatgaggcac ttggacttcc tacagtcaag     1200

tcggccagaa ttgccagaaa cacccaaatt atcatccagg aggaaagcgg aattccgaaa     1260

gttgcggacc catggggagg ctcctatatg atggagtgcc tgaccaatga tgtctacgac     1320

gccgccctga agctgatcaa tgagattgaa gagatgggcg ggatggccaa agccgtggcc     1380

gagggtatcc ctaaactcag gatcgaggag tgcgctgcca ggagacaggc gcggattgat     1440

tctggttcgg aagttatcgt tggcgtgaat aagtaccagc tggagaaaga ggacacggtg     1500

gaagtgctgg ctatagataa cacaagcgtg cgtaacaggc agatcgaaaa gttaaaaaag     1560

attaagtcct ctagggacca agcgttagct gagaggtgcc tcgctgctct gactgagtgc     1620

gccgccagtg gcgatggaaa tatcctcgcc ctcgccgtag acgcttctag agcacggtgt     1680

accgtcgggg aaatcaccga cgcacttaaa aaggtgttcg gagaacataa agccaacgat     1740

cgaatggtgt ccggcgccta caggcaggaa tttggggaga gcaaggaaat tactagcgcg     1800

attaaacgag tccataaatt catggagcgg gagggacgac gaccacgact gcttgtagcg     1860

aagatggggc aagacggaca cgacagaggc gctaaggtaa ttgctacggg atttgctgat     1920

cttggctttg acgtggatat cggcccactg tttcagacac cacgggaagt tgcccaacag     1980

gctgtagatg ccgatgttca cgccgtcggg attagcacct tggcggcagg tcacaagacg     2040

cttgttcctg agctgatcaa agagctgaat tccttgggga ggccagacat tctcgtcatg     2100

tgcggcggcg tcattccgcc ccaggattat gaatttcttt ttgaggtggg agtttccaat     2160

gtgtttggcc caggaacccg gattcctaag gcggccgtcc aggtgctcga cgatattgaa     2220

aaatgtctgg agaagaagca gcagagcgta                                      2250


<210>  130
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       A499T mutation

<400>  130
atgctgcggg ccaagaacca gctctttctg ctcagccccc attacctcag gcaggtgaaa       60

gagtcatctg gatccaggct tatccagcag agactgctac accagcagca gccactgcat      120

ccagagtggg cggccctcgc taagaaacaa ctgaaaggca agaatcccga agatctaatc      180

tggcatacac ctgaggggat cagtatcaaa cctctgtaca gcaaaaggga cactatggat      240

ttaccggaag aacttccagg cgtaaaacca ttcactcgcg gcccatatcc gaccatgtac      300

acatttaggc catggactat acgccagtac gctggctttt ccaccgttga agaatcgaat      360

aagttttaca aagataatat caaagctgga cagcaaggtc tgtctgtcgc atttgacctc      420

gcaacccaca ggggatacga ctctgacaac cctcgagtcc gcggcgatgt tggcatggcc      480

ggagttgcga tcgacactgt ggaagacaca aaaatcctgt ttgacggaat cccacttgag      540

aaaatgtcag tgagcatgac tatgaatggg gcggtgatcc ctgttttggc caactttatt      600

gtgacagggg aggagcaggg cgtgcctaaa gaaaaattga ctggtaccat tcagaatgat      660

atactgaagg aattcatggt gcgcaatacc tacatcttcc ccccggagcc gagtatgaag      720

atcatcgctg acatatttga gtatactgcg aaacatatgc ctaagttcaa ctcaatatct      780

attagtggct atcacatgca ggaggctggg gccgatgcca tattagagtt ggcttataca      840

cttgccgacg gcttggagta ctcgaggacc ggtctgcagg ctggcctcac gatcgatgag      900

ttcgctccaa gattgagctt tttctggggg attgggatga acttctatat ggagatcgcc      960

aagatgcggg ctggccgccg cttatgggct catctgattg agaagatgtt tcaacctaaa     1020

aactcaaagt ctctgctgtt gagagcccac tgtcagacgt caggctggag cctgacggag     1080

caggatccct acaataatat tgtgcggaca gcgattgaag ccatggcagc tgtatttggg     1140

ggcactcagt ccttgcacac caacagcttc gacgaagctt tagggctccc tactgtcaag     1200

tcagccagaa tcgcccggaa cactcagatc atcatacagg aagagagcgg cattcctaag     1260

gtagcggatc cctggggtgg gtcttacatg atggagtgcc tcacaaatga tgtctacgat     1320

gccgccctca agttgatcaa tgagatcgag gagatgggag gaatggcaaa agccgtcgca     1380

gaggggatac ccaaactgcg gattgaggag tgcgccgcgc gccggcaggc tcgcatcgat     1440

agtggaagcg aggtgattgt cggtgttaac aagtatcagt tggagaagga agacacagtt     1500

gaggtgctgg ctattgataa tacatcagtt cgtaacagac agattgaaaa actgaagaaa     1560

ataaaatcat caagggatca ggcattagcc gagcgttgtt tggccgcgct gacagaatgt     1620

gccgcatcag gtgacggtaa tatactggcc ctggctgttg atgcgagcag ggctcgctgc     1680

actgtggggg agatcacaga cgcactgaag aaggtcttcg gggagcataa agcaaacgac     1740

aggatggtca gcggggcata tcgccaagaa ttcggggagt ccaaggagat cacttcggcc     1800

attaagagag tccacaagtt tatggaaaga gagggtaggc gcccccgcct cctggtcgcc     1860

aaaatgggac aagatgggca tgaccgtggc gccaaagtta tagcaacggg atttgcagac     1920

ctcgggttcg atgtggacat tggacctctt ttccagacac cccgcgaagt ggcgcagcag     1980

gcagtggacg cggatgtaca cgccgtaggc atctctacat tggcggctgg tcacaagacg     2040

cttgtccctg agctcatcaa agagctgaac agcttaggcc gccctgacat cctggtcatg     2100

tgtggcggag ttattcctcc tcaggattac gaattcttgt ttgaggtggg cgtgagtaac     2160

gtgttcggac ctggaactag gattccaaaa gcagccgtac aagttttaga cgacatcgag     2220

aagtgcttgg aaaaaaaaca acagtctgtg                                      2250


<210>  131
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       R532H mutation

<400>  131
atgctgcgag caaagaatca gctgttccta ctatcgcctc actatcttag gcaggtgaag       60

gaatccagcg ggtctagact catacagcag aggctcctac atcaacagca gcccctacac      120

cctgagtggg ccgccttagc caagaagcag ctcaaaggta agaacccaga agatctgatc      180

tggcataccc ctgaaggcat ctccattaag ccattatatt ctaagcggga cactatggat      240

cttccagagg aattgccagg ggtaaaacca ttcacccgag ggccctatcc cacgatgtac      300

actttcagac cttggaccat cagacaatat gcagggttct caacagttga ggagtctaac      360

aagttctata aagacaacat caaggctgga caacagggat tgtcagtggc atttgattta      420

gccacccatc gggggtacga ttctgataat ccaagggtga gaggtgacgt gggaatggca      480

ggggtggcca ttgataccgt tgaggacacc aagattctct ttgacggtat ccctctggag      540

aaaatgagcg tgtccatgac tatgaatggc gcggtgatcc ccgttttggc caatttcatc      600

gtcactgggg aggaacaagg cgtcccgaag gagaagctga caggaactat ccaaaatgat      660

atcctgaaag agttcatggt ccgcaacaca tatattttcc cacctgaacc gtccatgaaa      720

attattgcag acatcttcga atacactgcg aaacacatgc caaagttcaa cagtatcagt      780

atctccggct accatatgca agaggctgga gctgacgcaa tcctggaact ggcttacaca      840

ttagccgatg gtttagagta ctcccgtaca gggctacagg ctggtctgac tatcgatgag      900

tttgccccac gactcagttt cttctggggg ataggtatga atttctatat ggagatcgcc      960

aagatgagag caggcaggcg cctttgggct catctcatcg agaaaatgtt tcagcccaaa     1020

aatagcaagt ccctcctact cagagcccac tgccagacca gcgggtggtc tctcacagag     1080

caggatcctt acaacaacat cgttcggact gcaatcgaag ccatggcagc agtgtttggg     1140

ggcactcaga gcctgcatac aaactcattc gatgaggcct tgggtctccc tacagttaag     1200

tctgcccgaa tcgccagaaa cactcagatc atcatccagg aggagtccgg catcccaaag     1260

gtggcagacc cgtggggtgg cagttatatg atggaatgtc ttaccaatga cgtgtacgac     1320

gctgctctaa agttaataaa cgaaattgag gaaatgggag ggatggcgaa agctgtcgcc     1380

gaaggaatcc caaagcttcg gattgaggag tgcgctgcta ggcgtcaggc tagaatagac     1440

tcggggagcg aagtcatagt gggagtcaac aagtaccagc tggaaaagga ggacgccgtc     1500

gaggtgctgg ccattgataa tactagcgta cgaaaccggc aaattgaaaa actgaagaaa     1560

atcaagagct ctagggacca ggctctggcc gagcactgcc tggctgccct gacagaatgc     1620

gctgcatctg gggacggcaa tatcctggct ctggctgtcg atgccagtcg agcccggtgc     1680

accgtgggcg aaatcactga cgctctcaag aaagtgtttg gcgagcataa agcaaatgat     1740

cgcatggtgt ctggcgccta ccgccaagag ttcggcgaat ctaaggaaat aacttctgca     1800

ataaaacggg tccacaaatt tatggagcgc gaagggcgta ggccgaggct tctcgtcgct     1860

aagatgggcc aggatggcca tgatagaggt gccaaagtga tcgctactgg attcgcggac     1920

ctgggcttcg atgtggatat tggtcccctc ttccagaccc ccagggaagt ggcccaacag     1980

gctgttgacg cagatgtgca cgctgtggga atcagcaccc tggctgctgg gcataaaacc     2040

ctcgtaccgg aattgattaa ggaattaaac agcttggggc gtcccgacat tctggtcatg     2100

tgtggggggg tgatcccacc acaggattac gagtttctct tcgaagttgg agtcagtaat     2160

gtctttggtc ctggtacaag gattcccaag gctgctgtgc aagtcctgga cgacattgag     2220

aagtgcttag agaagaagca gcagtctgtg                                      2250


<210>  132
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       R532H mutation

<400>  132
atgctaagag ctaagaatca gctgtttctc ttatcacccc actacttacg ccaggtgaag       60

gaatcatctg gatcgagact aatccagcag cgtctgcttc atcagcagca gcccttacat      120

ccggaatggg cagcacttgc taaaaaacag ctcaagggaa agaatcctga agatcttatc      180

tggcacactc cggagggcat ctcaatcaaa ccgttgtata gcaaacgcga tacaatggat      240

ctacccgagg aactgccagg agtgaaacca ttcacccgcg gaccctaccc cactatgtac      300

actttccggc cctggacgat ccggcaatac gccggcttca gcaccgtgga ggagtcaaat      360

aaattctata aggataatat caaggcggga cagcagggtc ttagtgtggc gttcgatctt      420

gccacacata gaggatacga ttcggacaat ccacgcgtac ggggagatgt cggcatggct      480

ggggtcgcca tagatacagt cgaagacact aagatcctct tcgacggaat cccccttgaa      540

aagatgagtg tgtcgatgac aatgaacggg gccgtcattc cggtgctagc caattttata      600

gttactggag aggagcaggg cgtgccaaag gagaaactca caggtacaat ccagaatgac      660

attctgaaag agttcatggt acgcaacact tacatctttc cacccgagcc cagtatgaaa      720

ataatcgccg atatcttcga gtacacggca aaacacatgc caaaatttaa ttccatcagc      780

atttccggat atcacatgca ggaggccggg gccgacgcaa tcttagaact ggcctacacc      840

ctggcggacg gattagagta ttctaggacc ggcctgcagg ccggcttaac tattgatgaa      900

ttcgctccca gattgagttt cttctgggga ataggtatga atttctacat ggagatcgca      960

aagatgcgtg ccggacggcg cctgtgggcc cacctaattg agaagatgtt tcagccgaag     1020

aatagcaagt ctcttctcct gagggcccat tgtcagacca gcggctggag ccttacggag     1080

caggatcctt acaacaatat tgtgagaacc gccattgagg ccatggccgc cgtcttcggt     1140

gggacccagt cgctgcacac aaactccttt gacgaggccc tgggtttgcc gacggtgaaa     1200

tcggcgcgca tcgcccggaa tacccagatc atcatccagg aggagtccgg aatcccaaag     1260

gtcgctgatc cttggggagg tagttacatg atggagtgtc tgactaatga tgtgtacgat     1320

gcggccctga aactgatcaa cgagattgaa gaaatggggg ggatggcaaa ggccgtcgcc     1380

gagggcatcc caaagttgcg catcgaagag tgtgctgcac ggagacaggc tagaatcgat     1440

tctggttccg aggtcattgt cggggtgaac aaatatcaac tggagaaaga agatgcagtg     1500

gaagtgctgg caattgataa cacaagcgtg cgcaaccgcc aaatcgagaa actgaaaaaa     1560

attaaaagct ctcgggatca agccctcgca gaacactgcc ttgcagctct cacggagtgc     1620

gctgcttccg gagatggaaa catcttagcg ctggcagttg atgcatcccg agcccgctgc     1680

accgtagggg agattacaga cgcattgaaa aaggtttttg gtgagcataa agccaatgat     1740

cgcatggtaa gtggagcata tagacaggag tttggggaga gtaaggaaat aacaagcgcc     1800

atcaagaggg ttcacaagtt tatggaacgg gaggggagac gcccacggct cttagtggca     1860

aaaatgggac aagacggcca cgaccggggc gctaaagtga tcgccaccgg cttcgcggac     1920

ctgggatttg atgtggacat cggtccgctg ttccagactc cgcgggaggt agcccagcag     1980

gcagtggacg ccgatgtcca tgcggttggg attagcacac tggcagctgg acacaagacc     2040

ttggtgcccg agctgattaa ggagttaaac tcactggggc gacccgatat acttgtgatg     2100

tgtggcggag ttatcccgcc ccaagactac gagttcttat tcgaggtggg tgttagcaac     2160

gtatttgggc caggcactag gatccctaaa gctgctgtgc aagtcctaga cgacatcgaa     2220

aagtgtctag agaaaaaaca gcagtctgtc                                      2250


<210>  133
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       R532H mutation

<400>  133
atgctccgtg ccaaaaatca gctctttcta ttatctccac attacctacg gcaagttaag       60

gagtcttctg gctcgcggct cattcaacag agattactac accagcagca gcccctgcat      120

cccgagtggg cagcattggc caagaagcag ctgaaaggta agaatcccga ggacctgatc      180

tggcacaccc ccgaaggaat ctctattaaa cccctttaca gcaaacgcga caccatggac      240

ctgcccgagg agctgcccgg ggtgaagcca tttactagag ggccataccc aaccatgtac      300

acatttagac cctggacaat tagacagtac gcgggcttta gtacagtcga agagagcaac      360

aaattttata aggacaatat caaggccggg caacagggcc tctcagtggc ctttgacttg      420

gctactcaca gaggctacga tagcgataac ccccgggtac gtggcgatgt gggtatggcc      480

ggagtggcaa tcgataccgt tgaagacact aagattcttt tcgacggcat tccacttgaa      540

aagatgtctg tcagtatgac aatgaatggt gctgtcatcc cggttttggc caattttatt      600

gtcacaggcg aggaacaagg cgtgccgaaa gagaagttaa caggcactat tcagaatgat      660

atcctcaagg agttcatggt gcggaacact tacatcttcc caccagagcc atcgatgaag      720

ataatcgccg acatcttcga gtataccgct aagcacatgc ctaaatttaa cagcatttct      780

atctccggct accacatgca ggaggccggc gcagatgcaa tcctggagct ggcttatacg      840

ctggccgacg ggcttgaata cagccggacc ggcctccagg ctggcctgac gatcgacgaa      900

tttgcccccc ggctttcttt tttctggggc atcggaatga acttctacat ggagattgcg      960

aaaatgcgag ctggtcggcg cctctgggcc catttgatcg agaaaatgtt ccagccaaag     1020

aactcaaagt cactgttact acgagcccat tgccagacat caggctggtc cctaaccgag     1080

caggatccct acaataatat agtgcgaact gcaatcgagg ctatggctgc cgtgttcggg     1140

ggaactcagt cactgcatac caactcattt gacgaggcac tcggtttgcc aacggtgaag     1200

tccgctagga tcgcacggaa tacccaaata attatccagg aggaatctgg tattcctaag     1260

gtggcagatc cctggggcgg tagctacatg atggagtgtc tcaccaacga tgtgtatgac     1320

gcggctctga agctgattaa cgagattgag gagatggggg gaatggcgaa agctgttgcc     1380

gaaggcattc ctaagctgcg catcgaggag tgcgcagccc gccgtcaggc cagaatcgat     1440

agcggttccg aagtaatcgt gggagtaaat aaataccagc tggaaaagga ggatgctgta     1500

gaagtgctcg ccatagataa cacttcagtt cgtaataggc agatcgaaaa actgaagaaa     1560

ataaaatcct cccgtgatca ggctcttgcc gaacattgct tggcggccct gacagagtgt     1620

gcagcctccg gggacggcaa catcctggct ctggcggtcg acgcaagccg ggcccggtgc     1680

actgtgggtg agattacaga cgctctgaag aaagtattcg gcgagcataa ggcgaatgat     1740

aggatggtca gcggtgctta ccgccaggag tttggcgaga gcaaagaaat tacctctgct     1800

ataaaaaggg ttcacaagtt tatggagagg gagggacgta gacctaggct tctggtcgca     1860

aaaatgggcc aggatggcca cgacaggggg gctaaagtga ttgcaactgg gtttgcagac     1920

cttggttttg acgtagacat aggacctttg ttccaaaccc ctcgcgaagt cgctcagcag     1980

gctgtcgacg ccgatgtgca cgccgtcggg atttcgacct tggctgctgg tcacaagact     2040

ttggttcccg aattaataaa ggaattaaac tcgctcggcc gacctgatat ccttgtgatg     2100

tgcggcgggg tcatcccacc ccaggactat gaatttctct tcgaggttgg cgtgtctaac     2160

gttttcggcc ccggaacacg gattccaaaa gcggctgtgc aggtgctgga tgacatcgag     2220

aagtgtttag agaagaaaca gcagtccgta                                      2250


<210>  134
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       R532H mutation

<400>  134
atgctgcgcg ccaagaacca gctcttcctg ctttctcccc actacctaag gcaagtgaag       60

gaaagtagcg ggagccggct catccaacaa agattgctac accagcagca acccctgcac      120

ccagagtggg ctgcactggc caaaaagcaa cttaagggca aaaatccaga ggatctgatc      180

tggcacaccc cagagggaat ctctatcaaa ccactctact ctaagcggga taccatggac      240

cttcccgagg aactgccagg ggtgaagccc ttcactagag gaccctaccc gaccatgtac      300

acatttcggc catggaccat ccgacagtat gccggttttt ctacagttga ggaatccaat      360

aagttctaca aggacaacat caaggcaggg caacagggcc tttccgtcgc gtttgacctc      420

gcaacacaca ggggctacga tagtgataac ccacgggtaa gaggagatgt tgggatggcc      480

ggcgtggcta tagacactgt ggaggatacg aaaattttat tcgatgggat ccccctggag      540

aagatgagtg tgagcatgac catgaacggc gctgttatac ccgtccttgc aaactttatc      600

gtcacaggtg aggagcaggg tgtgcccaaa gagaagctca cgggtacgat ccagaacgac      660

attcttaagg agtttatggt gagaaataca tatatcttcc cccctgaacc ttccatgaag      720

attatcgctg atatcttcga gtacaccgcc aagcacatgc caaaatttaa ctccattagt      780

atctcagggt accacatgca ggaggccggc gccgacgcaa ttctcgagct tgcatataca      840

ctggcagacg gactcgaata ttcacgcaca ggccttcagg caggtctcac tatcgatgag      900

tttgctcctc gactgtcttt tttctggggt atcggcatga atttttacat ggaaatcgct      960

aagatgcgcg ccggaaggcg gttgtgggcc catctgatcg agaagatgtt ccaaccaaaa     1020

aacagtaaat cccttcttct gagagcgcac tgccagacca gtgggtggag tttaactgag     1080

caggatccgt acaacaatat cgttcgaacc gccattgaag cgatggcggc ggttttcggc     1140

ggcacacagt ccttacatac gaattcattc gacgaggcct tgggcctgcc gaccgtcaag     1200

tcagcaagga tcgcgagaaa cactcagata ataatccagg aggagtccgg aatacctaag     1260

gtggccgatc cttggggtgg atcttatatg atggaatgcc tgactaacga tgtctacgat     1320

gccgcgctga agctaataaa tgaaatcgag gaaatgggag gtatggccaa ggccgtagct     1380

gagggtattc caaaactgcg tatcgaggaa tgcgctgcca gaaggcaggc gagaatcgat     1440

tcaggcagcg aggtcattgt aggcgtaaac aaataccagt tggagaagga agacgcagtt     1500

gaggttctcg ctattgacaa tacatctgtg cgaaaccggc agattgaaaa actaaaaaaa     1560

attaagagct cgcgggacca ggcactggct gagcactgct tggctgcact gaccgagtgt     1620

gcagccagtg gtgatggaaa tatcctggcc ctcgccgtcg acgcctcacg agcccggtgc     1680

accgtgggcg agattactga cgcactgaag aaggtgtttg gcgaacacaa ggcgaacgac     1740

cgaatggtat caggggccta ccgccaggaa tttggagagt cgaaggagat cacaagtgct     1800

atcaaacgcg ttcacaagtt catggagcgc gaagggcgcc ggccgcgtct actcgtagcc     1860

aagatgggac aggacggaca cgaccgggga gctaaggtga tagcgaccgg cttcgccgat     1920

ctggggtttg acgtggacat tggaccattg ttccagacgc ctcgagaggt ggcccagcaa     1980

gccgtcgatg ccgatgtcca cgcggttggc atatctaccc ttgccgctgg gcacaagacc     2040

ctcgtacctg agttgataaa agagttaaac tccctgggga ggccagatat tctggtcatg     2100

tgtggtggtg tcatcccacc ccaggattat gagtttttat tcgaggtggg tgtcagcaat     2160

gtctttggcc cggggacacg catccccaag gccgccgttc aggtgttaga tgacattgaa     2220

aagtgcttgg agaaaaagca gcagtccgtt                                      2250


<210>  135
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       R532H mutation

<400>  135
atgctgcgcg caaaaaacca gctgtttctc ctcagtcccc actacctgcg gcaggtgaag       60

gagtcttccg gcagtagact gatacagcag cgccttctcc accagcagca gccactgcac      120

ccagagtggg ccgcgctcgc aaaaaaacaa ctgaagggca agaatcccga ggacctgatc      180

tggcatactc cggaaggcat cagcattaag ccactttaca gtaaacgaga caccatggat      240

ctgccagagg aactaccagg cgtgaagcct ttcacaagag gaccttaccc aacaatgtat      300

actttccgtc catggactat tcgacagtat gcggggttct caacagtgga ggaatccaat      360

aagttctaca aagacaatat caaggccggc caacagggcc tgagtgttgc cttcgacttg      420

gccacccacc gtggatacga ttctgacaac ccaagggtgc gtggtgacgt cggaatggca      480

ggcgtggcaa tcgataccgt tgaagacacc aaaattctct tcgacggaat cccacttgag      540

aagatgagcg taagcatgac aatgaacgga gctgtgatcc ctgttctggc aaattttatt      600

gtgacaggtg aggaacaagg ggttcccaag gaaaagctaa cgggcactat ccaaaatgat      660

atattaaagg agttcatggt gcgtaacacc tatatttttc caccagaacc cagcatgaaa      720

atcatcgccg acatttttga atatactgca aaacatatgc ccaagttcaa ttccatcagt      780

atatccgggt accacatgca agaagccgga gccgatgcaa tcctcgagct ggcctatact      840

ctcgccgatg ggttagagta cagtcggact ggcctccaag cagggctaac tatcgacgag      900

ttcgccccaa gattatcttt cttctggggg ataggtatga atttttacat ggagatagcc      960

aagatgcggg caggaaggcg actgtgggcc catttgatcg agaaaatgtt tcagccaaag     1020

aatagcaaat ccttgcttct cagggctcat tgtcaaacca gcggatggag cctgacagag     1080

caggatccct acaacaacat agtgcggacg gctatcgagg ccatggccgc cgtgtttggg     1140

gggactcaat ccctgcatac caattcgttc gatgaggctc tgggactgcc aactgtcaaa     1200

tcagcccgca ttgcacgcaa tactcagata attatccagg aagaaagcgg catccctaag     1260

gtcgccgacc cctggggcgg gagctacatg atggagtgtc tcacaaacga tgtttatgac     1320

gccgctctga aactcattaa cgaaatagag gaaatgggag gtatggccaa agcagtggcc     1380

gagggtatcc cgaaactccg gattgaggag tgtgcagcta ggcggcaggc acgcattgat     1440

agtgggagcg aggtgattgt gggcgtgaac aagtaccagc tcgaaaaaga ggacgccgtc     1500

gaagtactgg ctatagataa cacttctgta agaaatcgcc aaattgaaaa attaaagaag     1560

ataaagagta gccgcgacca ggctctagca gagcactgtc tcgcagcact caccgagtgc     1620

gctgcaagtg gggatggtaa tatcctggct ctggctgtgg acgcaagccg ggcccggtgt     1680

acagtaggcg aaatcaccga cgccctcaag aaagtttttg gcgagcataa ggccaatgac     1740

cggatggtga gcggcgccta tcggcaagaa tttggcgagt ccaaagagat taccagtgct     1800

atcaaacggg tgcataagtt catggaaaga gagggccggc gccctcggct tttggtggca     1860

aaaatgggcc aagatggtca tgatagaggc gcgaaagtca tcgcaaccgg cttcgccgac     1920

ctgggcttcg acgttgatat tggcccacta ttccagaccc ctagagaagt ggcccaacag     1980

gccgttgatg ccgacgtgca cgcagtgggt attagcacac ttgcagctgg ccacaaaaca     2040

ctggttcctg agctcatcaa agagctgaat agcttaggcc ggcctgatat cctggtgatg     2100

tgcggcggcg ttattccgcc ccaggattat gaattcctgt ttgaggtcgg tgtgagcaat     2160

gtcttcggtc caggaacaag aattcccaag gcagccgtgc aggtactcga tgacatcgag     2220

aaatgcctgg agaagaagca gcagagcgtt                                      2250


<210>  136
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       R532H mutation

<400>  136
atgctgcgcg ccaagaacca gttgttccta ttaagccccc actacctcag gcaggtgaag       60

gagtcaagtg gatctcgact gatccaacaa agattattgc accagcagca gcccctccat      120

cctgagtggg ccgctcttgc gaagaaacag ctcaagggga agaatcctga ggacctgatt      180

tggcacaccc cagaaggaat cagcatcaag cccttgtata gcaagaggga caccatggat      240

cttcctgagg agctcccggg tgtgaaacca ttcacaaggg ggccgtatcc cacaatgtac      300

acttttcgac cctggacgat ccggcagtac gcaggattct cgactgtgga agaatccaac      360

aagttttata aagataacat caaggccggc cagcaaggac tgtctgttgc tttcgaccta      420

gccacccaca gggggtatga cagcgataat ccgcgcgtaa ggggagatgt gggcatggct      480

ggcgtggcaa tcgacaccgt tgaggacacc aagatattat tcgatgggat cccactggag      540

aagatgtccg tctccatgac catgaacgga gcagtcatac ccgtgttggc gaactttatc      600

gtgaccgggg aagaacaagg tgttccgaaa gaaaagctga cgggcaccat tcaaaatgac      660

attttgaaag agttcatggt acgcaatacc tacatcttcc cccctgagcc ctctatgaag      720

atcatcgcag acatcttcga atacacggcc aagcatatgc caaagttcaa tagtatcagt      780

atcagtgggt accatatgca ggaagccggc gcggatgcca tcttggagtt ggcctataca      840

ttggcagatg gccttgagta ttctaggaca ggactccaag ccggcctgac aattgacgag      900

ttcgctccac gcttgagctt cttctggggg atcggaatga acttttacat ggagattgcc      960

aaaatgagag ccgggcgccg gctttgggca cacctgatcg aaaagatgtt ccagcccaaa     1020

aactctaaat ctcttctgct acgcgcccat tgccagacca gtggatggtc acttactgag     1080

caggatcctt ataacaacat cgtcagaaca gccattgagg ccatggccgc agtatttggg     1140

ggcacccagt ccctgcatac aaacagcttt gacgaagcct tgggactgcc tacagtgaaa     1200

agtgccagga tagctcgcaa tacacagatc attatccagg aggagagtgg catcccaaag     1260

gttgcggacc cgtggggggg cagttatatg atggaatgct taaccaatga tgtgtatgac     1320

gcggcgctga aactgatcaa cgaaatagaa gaaatgggcg ggatggcaaa agctgtggcc     1380

gaaggaattc ccaagctgag aattgaagaa tgcgcagccc ggcgtcaagc caggatcgac     1440

agcggatccg aagttatcgt gggggtaaat aaatatcagc ttgaaaaaga ggatgcagtg     1500

gaagtcttgg caatcgacaa tacgtctgta cggaatcggc agatcgaaaa gctcaagaag     1560

ataaagtcaa gtagggatca ggcccttgct gagcattgcc ttgctgcttt aacagaatgt     1620

gccgccagcg gggatggcaa catcctagcc ctagctgtgg acgcttcgag ggctaggtgt     1680

accgtggggg agataaccga tgcactgaag aaggtctttg gagagcacaa agcaaacgat     1740

cgcatggtga gtggggccta cagacaggaa ttcggtgaaa gcaaagaaat tacaagcgca     1800

atcaagagag tgcataagtt catggaacga gagggaagga gacctcggct gctggtggcg     1860

aaaatgggtc aagacgggca cgacagagga gccaaagtta ttgcgaccgg attcgctgat     1920

ttggggtttg acgtcgatat cggaccactg ttccagaccc cccgagaagt agcgcagcag     1980

gctgtggatg cagacgttca tgctgtaggt atttcaacac tggcagcagg ccacaagacc     2040

ttggtccctg agctgataaa agagctcaat tctttgggca gaccagatat actcgtgatg     2100

tgcggaggtg tgatcccccc acaggactat gagttcctgt tcgaggtggg agtgtcaaac     2160

gttttcggcc ctggaacgcg aatccccaaa gcagcagtgc aggtcctaga tgacatcgaa     2220

aaatgcttgg agaagaagca gcaatccgtg                                      2250


<210>  137
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       R532H mutation

<400>  137
atgttgcgag ctaagaatca gcttttcctc ctatcccctc actacctccg acaagtgaag       60

gagtccagtg gttctagact gatccagcaa aggcttctgc accagcagca accgttgcac      120

cctgagtggg ctgctctcgc caagaaacaa ctgaagggga aaaatcctga agatctcatc      180

tggcacaccc ctgaaggcat ttccatcaag cccctctaca gcaaacgaga taccatggat      240

ctgcccgagg agctgcccgg agtaaagcct tttaccaggg ggccctatcc caccatgtat      300

actttccggc cttggactat tagacagtat gccgggtttt ctacggtgga ggagtcaaat      360

aagttttaca aggataacat caaggctggt cagcaaggcc tgtcagtggc ttttgatctc      420

gcgactcatc ggggttacga ttccgataat ccacgggtgc gaggagatgt gggcatggct      480

ggggtcgcca ttgacacagt ggaggacaca aagatccttt tcgacggcat ccctctggag      540

aaaatgagcg tgagcatgac catgaatggt gccgtgatac cagtgctggc caattttatc      600

gtgactgggg aggagcaggg agtgcccaag gagaagctga caggaacaat tcagaatgac      660

atactgaagg agtttatggt aagaaacacc tacatctttc ccccagaacc cagcatgaag      720

ataattgccg acatcttcga atataccgcg aagcacatgc cgaagttcaa ctctatcagc      780

atctctggat atcacatgca ggaagcagga gccgacgcca tccttgagct tgcgtacact      840

ttggccgacg gccttgagta ctcacggacc ggccttcagg caggacttac aatagacgag      900

ttcgccccga gactgtcctt tttttggggg attgggatga acttttacat ggagattgcc      960

aaaatgcggg ccgggagaag attatgggcg cacctgatcg agaaaatgtt ccagcctaag     1020

aactccaagt cactgcttct gcgggcccac tgtcagacca gcggctggag tctgactgag     1080

caggaccctt acaacaacat cgtgcgcacc gcaatagagg ccatggctgc tgtgtttgga     1140

gggacccagt ctcttcatac caattccttc gacgaggcac tgggcctgcc caccgtgaaa     1200

tctgcccgta ttgcccggaa cactcagatc atcatccagg aagagtctgg cattccgaaa     1260

gtggcggacc cctggggagg atcgtatatg atggagtgtt tgaccaatga tgtctacgac     1320

gctgcactga aacttatcaa cgagatcgag gaaatgggtg ggatggccaa ggctgttgcc     1380

gaggggatcc ctaaactccg aattgaagaa tgtgccgcac gccggcaggc ccgcatagac     1440

tcgggctcag aggtcattgt tggggtaaat aaataccagt tggagaagga ggatgccgtt     1500

gaggtcctgg ccatcgataa caccagcgtg agaaataggc aaattgagaa gctgaaaaaa     1560

attaagtctt caagggatca ggccctggcg gagcactgtc tagccgccct aactgagtgt     1620

gccgcctcag gcgatggcaa cattctggct ctggctgtgg acgcgtcccg cgctaggtgt     1680

acagtgggtg agattacaga cgcactcaaa aaggtgttcg gggaacacaa ggctaacgac     1740

cgtatggtgt caggagccta ccggcaggag tttggcgaat cgaaggaaat aacatcagcc     1800

attaagaggg tgcacaagtt tatggagaga gagggaagac gcccccggct gctagtggca     1860

aaaatgggcc aagatggcca cgaccgggga gcgaaagtta ttgcaacagg gttcgcagat     1920

ttgggattcg acgttgacat cggtccgctg tttcagacac cccgagaggt ggcacagcag     1980

gctgttgacg cggatgtgca cgccgtgggg atttctacgc tcgccgccgg acataagacg     2040

ctagtcccag agttgattaa ggagcttaac tccctgggca ggccggatat tctggttatg     2100

tgtgggggag tcatcccgcc acaggactac gagttcctgt tcgaagtcgg ggtctctaat     2160

gtgtttggac cgggcactag aatcccaaag gccgctgtgc aggtcctgga cgatatcgag     2220

aaatgtctcg aaaaaaagca gcagtcggtg                                      2250


<210>  138
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       R532H mutation

<400>  138
atgctgaggg ccaagaatca actgttcctt ctgtcccctc actatctgcg ccaggtcaaa       60

gagtcatccg gcagcaggct catacagcaa aggctgcttc accagcagca acccctacac      120

ccagaatggg cagctttggc gaaaaagcag ttgaaaggta agaacccgga agacctgatc      180

tggcacaccc ccgagggcat ttcaatcaaa cccctgtata gcaaacggga cacaatggac      240

cttcctgagg aattgccagg ggtgaaaccc ttcacccgag ggccataccc aactatgtac      300

actttcagac cttggaccat cagacagtat gctggattta gcacggtgga ggaatcaaac      360

aagttttaca aagataatat caaggccggt cagcaggggc tgagcgtcgc gttcgacctg      420

gcgacacacc ggggatatga ttccgataat cctcgggtca gaggggatgt ggggatggcc      480

ggcgttgcca ttgataccgt cgaggacacc aaaatactgt tcgacggaat ccccctcgag      540

aaaatgagcg tgtctatgac aatgaatggg gctgttattc cggtcctggc aaattttatc      600

gtcacaggag aggagcaggg ggttcctaaa gagaagctga caggtacaat ccagaatgat      660

atcctcaagg aatttatggt caggaatacc tacatcttcc cgcctgagcc atcaatgaag      720

attatcgccg acatttttga atatactgcc aaacacatgc ccaaattcaa ttctatctcc      780

atatctgggt accatatgca ggaggccggc gccgacgcca tccttgaact cgcttataca      840

ctcgccgatg gactggagta ttctcgcact gggttacagg ccggcctcac tattgatgaa      900

ttcgcaccaa gactaagctt tttctggggg atcggcatga atttctatat ggaaatcgct      960

aagatgcggg ccggaagaag actgtgggct catctgattg agaaaatgtt tcagcccaag     1020

aacagtaaat ccctgctgct ccgcgcacac tgccagacat caggttggtc tcttaccgaa     1080

caggacccct ataataacat cgtgaggact gccattgaag caatggctgc tgtgttcggg     1140

gggacccaat ctctgcacac aaactctttc gacgaagccc tgggcctacc tacagtcaag     1200

agcgccagaa tcgcaaggaa cactcagatc attatacagg aagagtcagg gatacctaag     1260

gttgccgatc cctggggcgg ctcctacatg atggagtgcc taacaaatga cgtgtatgac     1320

gccgcactca agctgatcaa cgaaatagaa gagatgggag gtatggcaaa agcagtagct     1380

gaaggcatac ctaaattgcg gatcgaggag tgcgccgcga ggaggcaagc cagaatcgat     1440

agtggaagtg aggtaatcgt aggcgtgaat aagtatcagc tggagaaaga agacgccgtg     1500

gaggttctag ccatcgataa cacctcagtg aggaaccgtc agattgaaaa gcttaaaaag     1560

atcaaatcat cacgggatca ggctctagcc gagcactgcc tggccgcact gactgaatgc     1620

gcagcttctg gcgatggaaa tatcctggca ctagcagtgg acgcgtctcg ggctcgatgt     1680

acagttggag aaataacaga tgccttaaag aaagtatttg gggaacataa agcaaacgat     1740

aggatggtga gtggggctta ccgacaggag tttggcgaaa gtaaagagat cacatcagct     1800

atcaaaagag tgcataagtt tatggaacgc gagggacgga ggcctcggtt gctggtggcc     1860

aaaatgggcc aggatggcca cgatcgcggg gccaaggtca ttgctactgg ctttgctgat     1920

ttgggatttg acgtggacat cggtcctttg ttccaaacgc ccagagaggt ggcccaacag     1980

gcggtggatg ccgacgtgca cgcggtcggc atctctactc tggcagcagg acacaaaacc     2040

ctggtcccag agctgataaa ggagctgaat tcacttggcc gccccgacat cctcgtgatg     2100

tgcgggggtg ttattcctcc ccaagactac gagttcctgt tcgaagtggg cgtcagcaat     2160

gtgtttggac ctgggacgag aatacccaag gccgccgtgc aggttttgga tgatatcgag     2220

aaatgcctag aaaagaagca acagtcggtc                                      2250


<210>  139
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       R532H mutation

<400>  139
atgctacggg ccaagaatca gctttttctc ttatcccctc actatctgcg acaggtaaag       60

gagagctccg ggtcacgcct gattcagcaa cggttactcc accaacagca accgttgcat      120

cctgagtggg ccgcactcgc aaagaagcag ctgaaaggga agaacccaga agacctcata      180

tggcatacgc ccgaaggaat ctccatcaag cccctttaca gcaagagaga cacaatggat      240

ctgccggaag aattgcccgg cgtgaagcct tttactcggg gaccatatcc aactatgtat      300

actttcagac cctggaccat tcgccaatat gccggctttt ctacagtgga ggaaagtaac      360

aagttttata aggataatat aaaagccgga cagcaggggc tgagtgtggc ctttgatctt      420

gccacacaca ggggctacga ttcggacaat ccccgcgtca ggggtgacgt gggaatggct      480

ggcgtggcta tcgataccgt ggaagacact aagattttgt tcgacggaat cccactcgaa      540

aagatgtcag tttctatgac catgaacggc gccgtgatcc ctgtcttggc gaatttcatc      600

gtaacaggcg aggagcaggg tgtgccaaag gaaaagctca cagggaccat ccagaacgac      660

atcctcaagg aatttatggt gcggaataca tatattttcc caccagagcc tagcatgaag      720

atcatcgcag acatctttga gtataccgct aaacacatgc ccaagtttaa cagtatttcc      780

atttcaggct accacatgca ggaagcggga gctgacgcaa tccttgagtt ggcatatacg      840

ttggccgatg gactggagta tagccgcacc gggcttcagg caggccttac aatcgatgag      900

ttcgcaccca ggttaagttt cttttggggt attgggatga atttttacat ggaaatagca      960

aagatgcggg ccggcagacg gctgtgggcg catctgatag agaagatgtt ccagccgaag     1020

aacagtaaat cactgctgtt gcgggctcac tgccagacca gcggatggtc tctgactgaa     1080

caagacccct acaacaatat cgtgagaact gccatcgagg ctatggccgc agtctttgga     1140

ggcacccagt ctctacacac aaattctttc gacgaggccc tcgggctgcc caccgtgaag     1200

agcgctcgta tcgcgcgtaa tacccaaatt attatccaag aggagtctgg cattcctaag     1260

gtggccgacc cttggggcgg ttcatatatg atggagtgcc tcactaacga cgtctacgac     1320

gccgcactca agctgattaa tgagattgag gagatggggg gcatggcaaa agctgtggcc     1380

gaaggcatcc ccaaactcag aatagaagaa tgcgccgcca ggcgacaggc taggatagat     1440

tcaggctccg aagtcattgt gggcgtgaac aaatatcaat tggagaagga ggacgccgta     1500

gaggtgctcg caatcgacaa tacatccgtt aggaacagac aaatcgaaaa actgaagaaa     1560

attaaaagct cacgcgatca ggctctggca gagcattgtc tggccgctct gacagagtgc     1620

gccgcaagcg gggatggcaa cattctggca ctggccgtgg acgcaagccg cgctagatgt     1680

acggtcgggg aaatcacaga tgccctcaag aaagtgttcg gagagcacaa agccaatgat     1740

cggatggtct ctggagccta ccgacaagag ttcggtgaga gcaaagagat tacaagcgcg     1800

attaagaggg tgcacaagtt catggagcgt gagggacggc ggccaaggct gctcgtggcg     1860

aagatgggac aggatgggca tgaccggggc gctaaagtga ttgcaacagg gtttgcagat     1920

ctgggatttg atgtagacat tggcccctta ttccaaaccc cgagggaggt agcacagcag     1980

gcagtagatg ccgatgtgca cgccgtgggg atttccacct tggcagccgg tcacaaaacg     2040

ctagtgcctg agctgatcaa agaactcaat agtcttggaa ggccagatat actggtcatg     2100

tgcgggggtg tgattccgcc ccaggattat gagttcctgt tcgaggtagg tgtgagcaac     2160

gtgttcggcc ctgggactcg gataccgaag gccgctgtgc aagtcctgga cgatattgaa     2220

aagtgcctcg agaaaaagca gcagtccgtc                                      2250


<210>  140
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       R532H mutation

<400>  140
atgctgcgcg ctaagaatca gcttttcctg ctcagccctc actatcttcg tcaggtaaaa       60

gagtctagcg gttccaggct catccagcag agattgttac accagcagca gcctctgcac      120

cctgaatggg ccgcactcgc aaagaaacag ctgaaaggaa agaacccgga agacctcatc      180

tggcatacac cagagggcat ctcaatcaag ccactttact ccaaacggga tactatggac      240

ctccctgagg agctgcctgg cgtaaagccc tttactcgtg gaccgtaccc tacgatgtat      300

acctttagac catggaccat caggcagtac gcaggcttta gtactgtcga ggagagcaat      360

aaattttata aagataatat caaggccggg cagcagggac tctcagtcgc gtttgacctg      420

gccactcatc gcggttacga cagcgacaat cctcgagtga gaggggacgt gggcatggct      480

ggtgtcgcga tagacactgt ggaagataca aagatcctat ttgacggaat tcctcttgag      540

aaaatgagtg tttcaatgac aatgaatggg gcggtgatcc ctgtgcttgc caactttatc      600

gttactggcg aagaacaagg cgttccaaaa gagaaactga ctggaaccat tcaaaatgac      660

attttaaagg aattcatggt ccgaaatact tacatctttc cacccgagcc aagtatgaag      720

attattgcag acatctttga gtatactgcc aaacacatgc ctaagttcaa cagcatttct      780

atctcagggt accacatgca ggaggccggc gcagacgcaa ttctggagct ggcgtataca      840

cttgctgatg gtctcgagta cagccgcaca ggactgcaag ccggtctgac tatcgatgag      900

ttcgctccca gactctcttt tttctgggga ataggcatga atttttatat ggagatagcg      960

aagatgagag ccgggaggcg gctatgggcg cacttgatcg aaaaaatgtt tcaaccaaag     1020

aattcgaagt cgctcttgct gcgcgctcac tgccaaacgt ccggctggtc actgactgaa     1080

caggatcctt acaacaacat tgtcaggact gccattgagg cgatggcagc agtgtttggg     1140

gggacccaat ccttacacac taatagcttt gacgaggccc ttggactccc cacggtgaag     1200

agtgcaagga ttgctagaaa tacccagatt atcattcagg aggagtcagg cataccaaaa     1260

gtcgcagacc cctggggggg gtcatacatg atggaatgcc tcactaacga tgtctacgat     1320

gcagcgctga agctcatcaa cgaaattgaa gaaatgggag gaatggccaa agccgtagca     1380

gaggggattc ccaaactgag gatagaggaa tgcgccgccc ggcgccaggc gcgcattgac     1440

agcggctccg aagtgattgt cggcgttaac aaatatcagc tcgaaaaaga ggacgctgtg     1500

gaggtccttg ccatagataa cacatcagtg cggaaccgcc agattgagaa gcttaaaaag     1560

ataaagagct cacgggacca ggccctggcc gagcactgtc tggcggccct caccgagtgc     1620

gccgccagcg gggacggcaa catacttgcc ttagccgtgg acgcctcgag agcaaggtgc     1680

acagtcggag agattaccga cgctcttaag aaggtcttcg gagagcacaa ggctaatgac     1740

agaatggttt ctggcgcata taggcaggag tttggtgaat caaaggaaat cacatctgca     1800

atcaagagag ttcacaagtt catggaacgg gaggggcgga ggcctcgact gctggtcgca     1860

aaaatggggc aggacggcca cgatcgcggg gctaaggtga tcgccaccgg cttcgccgac     1920

ctggggtttg acgtggatat tggaccactg tttcagacac ctcgcgaggt ggctcagcag     1980

gccgtggatg ccgatgtgca tgccgtaggg atctccaccc tggccgccgg acacaagaca     2040

ctcgtaccag agctgattaa agaactcaac tcacttgggc gacccgacat tctagtcatg     2100

tgtggtggag tgataccacc ccaggactac gaatttctgt ttgaagttgg tgtgtctaat     2160

gtattcggcc ctggcacacg aattcctaaa gctgctgtgc aggtgttgga tgacatcgaa     2220

aagtgcctcg agaagaagca gcagtctgtt                                      2250


<210>  141
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       T598A mutation

<400>  141
atgctccggg caaagaatca gttatttctg ttaagcccgc attacttgag acaagtgaag       60

gagtccagcg gatctcggtt aatccagcaa cgactgctgc accagcaaca gcctcttcac      120

cctgaatggg ctgcactggc caagaagcaa ttgaagggca aaaaccccga agacctgatt      180

tggcacaccc cggagggaat ctcgataaag cccttgtact ccaagaggga taccatggat      240

ctccccgaag aattgcctgg cgtcaaaccg ttcactcggg ggccataccc caccatgtac      300

acattccgcc cttggacaat cagacaatat gccggattct ctaccgtgga ggaatccaac      360

aaattctaca aagataatat caaggctggg cagcagggac tatcggttgc atttgacctg      420

gctacccacc gcgggtatga cagtgataac cccagagtaa ggggagatgt cggcatggct      480

ggcgtggcca tcgatactgt tgaagacacc aaaatcctgt tcgacgggat tcctctcgaa      540

aaaatgtctg tgtccatgac tatgaacggc gcagttattc ctgtgctggc caatttcatt      600

gtaacgggcg aggagcaggg agtgccaaag gagaagctta cgggcaccat acagaacgac      660

atcctaaagg agttcatggt gagaaatact tacatctttc cccccgaacc ctctatgaag      720

attatcgctg acattttcga atataccgcc aaacacatgc cgaaattcaa ctccatctcc      780

atttccggct accacatgca ggaggccggc gccgatgcca tcctagaact cgcctatacc      840

ctcgcagacg gattggaata cagtcgcact ggcctccaag caggactgac aatcgatgag      900

tttgctccca gactttcctt cttctggggc attggaatga acttttatat ggaaattgca      960

aaaatgaggg ccggcaggcg cctgtgggct cacctcattg aaaagatgtt ccagcccaaa     1020

aacagcaagt ctttgttgtt aagagcccat tgtcaaacat ctggatggag cctgaccgaa     1080

caggacccat acaataacat tgttaggacg gccattgagg ccatggcggc cgtattcggc     1140

ggtacccaat ccttacacac caatagcttt gacgaagcct tgggcttgcc tacagtgaag     1200

tctgccagga ttgcgcgcaa tacccagatt ataatccagg aggagagcgg cattccaaaa     1260

gtcgcagacc cgtggggggg tagctatatg atggagtgtc ttaccaacga cgtatacgat     1320

gctgctctga agctcatcaa cgaaatcgaa gagatgggag ggatggccaa ggcagtcgcc     1380

gaggggattc ccaaattacg gattgaagag tgtgccgcga ggaggcaggc cagaattgat     1440

agtggatccg aggtgatcgt tggggtgaat aagtatcaac ttgagaaaga ggacgccgtt     1500

gaggtgctcg ccatcgacaa tacatcagtc agaaacaggc aaatcgagaa gctgaaaaag     1560

atcaaaagct cgcgagacca ggcactggcc gaacgatgct tggccgctct caccgagtgc     1620

gcggcctctg gagatgggaa tatcctcgcc ctcgctgtcg atgcatctcg tgcgcggtgc     1680

acagtgggtg agattaccga tgccctgaag aaagtgttcg gggaacacaa ggctaacgac     1740

cgaatggttt caggagccta taggcaggag ttcggcgagt caaaggaaat agcttctgcg     1800

attaaacgtg tgcataagtt catggagagg gagggacggc gccccagact tttagtcgcc     1860

aagatgggtc aggatggcca cgacaggggc gctaaggtga tcgctacagg cttcgcagac     1920

ttagggttcg atgtcgacat tggacccctt tttcagactc cacgggaagt agctcagcag     1980

gctgtcgatg ccgacgtaca tgccgtaggc attagtaccc tggctgctgg ccacaagaca     2040

ctcgtcccag agctgattaa agaattaaac agtctcggcc ggcccgacat actggtcatg     2100

tgcggtggag tcatccctcc tcaggattat gagttcttgt tcgaagtggg ggttagtaat     2160

gtgttcggcc caggcacacg aatccctaag gccgccgtgc aggttctgga cgatattgaa     2220

aagtgcctgg aaaagaagca acagtcggtg                                      2250


<210>  142
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       T598A mutation

<400>  142
atgctccggg ctaaaaacca actctttctt ttgtctcctc actatctgcg acaggtcaaa       60

gagagctccg gaagcagatt gatccaacag cggctgctgc atcagcagca gccactacat      120

ccagaatggg ccgctctggc aaagaagcag ttgaaaggta aaaatcctga ggatctgata      180

tggcacaccc cagagggtat atccattaaa cccctttact ctaagagaga cacgatggac      240

ctccctgaag agttgcccgg ggtgaagccc ttcactcgcg ggccatatcc aacaatgtac      300

acattccgcc cgtggacaat ccggcagtat gccggatttt ccactgtgga agaatctaac      360

aagttttata aggataatat aaaggcgggc caacagggtc tgtctgtggc cttcgatctg      420

gccactcatc gcggctacga ctcagacaat ccaagagtga gaggcgacgt cggcatggct      480

ggtgtcgcca tcgacactgt agaagatacc aaaatcctct tcgacggaat acccctggaa      540

aagatgtcag tttctatgac tatgaatggc gccgtcatcc ctgtcctcgc aaacttcata      600

gtgacaggag aagaacaggg agtacctaaa gagaagttaa ctgggacaat ccagaatgat      660

atcctgaaag agtttatggt acgcaatact tacatcttcc cacctgagcc cagtatgaag      720

attatcgctg atattttcga atatacagcc aaacacatgc caaaattcaa ctctatctca      780

atcagtggct accacatgca ggaggccggc gccgacgcaa tccttgaact ggcatacacg      840

ctggccgatg gcctggaata tagtcggact ggcctgcagg ccgggctgac tattgacgaa      900

tttgcacccc gtctgtcttt tttttgggga atcggcatga atttttacat ggagatcgcc      960

aagatgaggg ctggcaggcg tctgtgggct cacctgatcg aaaagatgtt ccaacccaaa     1020

aattcgaagt ccctgctttt aagggctcat tgccagacca gtggctggtc tctcaccgag     1080

caagatccct ataacaacat cgtgagaact gccattgaag ccatggcagc agtattcggc     1140

ggcacgcaaa gtctccacac aaattcattt gatgaagcct tggggttacc caccgtaaag     1200

agcgctcgca tcgcccggaa tacccagatt attattcagg aggagtcggg tatccctaag     1260

gtcgctgatc catggggagg ctcttacatg atggaatgcc tgacgaacga cgtttacgat     1320

gcagcactga aactcattaa tgagatcgaa gagatgggag gtatggccaa ggccgtggcc     1380

gagggcatcc ctaaactgag gatagaggag tgtgctgcac gaaggcaggc acgtatcgac     1440

tctggctctg aagttatcgt gggggtgaat aagtatcagc tcgagaaaga ggacgccgtc     1500

gaagtgctgg ctatagacaa tacctctgta cggaatagac aaattgagaa actcaagaag     1560

ataaagagta gcagagacca agctcttgcg gagcgatgcc ttgccgcttt gactgagtgc     1620

gccgcctctg gcgacggaaa cattctggct cttgcagtgg acgcctcgcg ggcccggtgc     1680

acagttggcg agattactga cgctttgaag aaagtctttg gcgagcacaa agctaacgac     1740

cgaatggtgt ccggagccta tcggcaagaa tttggagagt ccaaagaaat tgccagcgcc     1800

attaaaagag ttcacaagtt tatggaacgc gagggccgac gacctagatt gctagttgcg     1860

aaaatgggtc aggacgggca tgatagaggg gccaaggtta tcgctaccgg attcgctgac     1920

ctcggtttcg acgttgatat cgggccatta ttccaaaccc cacgggaggt ggcccaacaa     1980

gccgtagatg ctgatgttca cgccgttggg atcagtaccc tcgcagcagg tcataaaacc     2040

ctggtacccg agctgattaa ggagctgaat tccttgggcc gtccggacat actcgtcatg     2100

tgcggcggcg taatcccacc ccaggactat gagtttctgt tcgaagtcgg cgtcagcaat     2160

gttttcggcc cgggcactcg cattccgaaa gccgcagttc aggtgctcga cgacatcgaa     2220

aaatgcctgg agaagaagca gcagtctgta                                      2250


<210>  143
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       T598A mutation

<400>  143
atgctgcgcg ccaaaaacca actgttcctg ctgtcacctc actacctccg gcaagtgaaa       60

gagagcagtg gttcaagact gatacagcaa cggcttctcc accaacagca accactgcac      120

cccgaatggg ccgctctggc taagaaacag ctcaagggca agaatccaga ggatctcata      180

tggcataccc ctgaaggcat cagcattaaa cccctttata gcaagaggga taccatggat      240

cttcccgagg agcttcccgg cgtaaagccc tttacaagag ggccttatcc taccatgtac      300

acgtttaggc catggacaat taggcaatat gctggattta gtacagtgga agaatctaat      360

aaattctata aagacaatat taaggcaggc cagcaaggtt tgagtgtggc ctttgatctg      420

gctacccacc gcggttacga tagtgacaac cctagggtac gcggagatgt cggtatggct      480

ggagtcgcta tagatacggt cgaagataca aaaattttgt tcgacggaat tcccctggag      540

aagatgtctg tgagcatgac gatgaatggg gctgtgatac ccgttctggc aaacttcatc      600

gtgaccggag aggagcaagg cgtcccgaag gaaaagctga ccgggaccat ccagaatgac      660

atcctcaagg aattcatggt aaggaatacc tacatattcc ccccggagcc ttctatgaag      720

atcattgcgg acattttcga gtacactgca aagcatatgc cgaaatttaa ctccatttca      780

atttctggtt accacatgca ggaggccggc gccgatgcaa ttctggaact cgcttacact      840

ctcgccgatg ggctcgaata cagtcggaca ggactccagg caggacttac tatcgatgag      900

ttcgcaccca ggctgagttt cttctgggga attgggatga atttctatat ggagatcgca      960

aagatgcgtg cgggtcggag gctgtgggcg catcttattg aaaagatgtt ccagccaaaa     1020

aatagcaagt ctctcttact cagggcccac tgtcagacgt cagggtggtc tttaacggag     1080

caagatcctt ataacaacat tgtcaggacg gccatcgagg ctatggccgc agtcttcggg     1140

gggactcagt ctctgcacac aaacagcttt gacgaggccc tgggtctacc aacggtcaaa     1200

agcgctagaa tcgctcgcaa tactcagatt atcatccaag aagaaagtgg gattcccaag     1260

gtagctgacc cttggggggg gtcgtacatg atggaatgtt tgacaaacga cgtgtatgac     1320

gccgctctga aactgattaa cgaaatcgaa gagatgggtg gaatggctaa ggctgttgca     1380

gaggggatcc caaaacttag aatcgaggaa tgcgctgcgc gcagacaggc tagaatagat     1440

agcgggtcag aggtgatagt gggggtgaac aaataccaac tcgagaaaga agatgccgtt     1500

gaagtgctgg ctatagataa cactagtgtc cggaacagac agatcgaaaa attgaaaaag     1560

ataaaaagta gtagagatca agccttggct gagcggtgcc tggccgcact gacagaatgt     1620

gccgccagcg gggatggcaa cattctggcc ttagccgtgg acgccagccg ggctagatgt     1680

actgtagggg agattacaga cgccctgaag aaagtgtttg gagagcataa agccaatgac     1740

aggatggtgt caggcgccta tagacaggaa tttggggaga gcaaagagat agcttctgcc     1800

attaaacgtg tacacaaatt catggaaaga gaggggcgcc gcccgcgctt actggtggcc     1860

aagatggggc aggacggaca tgatcgaggt gccaaggtca tcgcaactgg attcgcagat     1920

cttggatttg atgtggatat tgggcctctc ttccagactc ctcgggaggt cgcccagcag     1980

gcggttgacg cagacgtaca cgccgttggc atctcaactc tggcggcggg acacaaaaca     2040

cttgtccctg agctgatcaa ggagctgaac tccctgggaa gacctgacat tctggtcatg     2100

tgcggcggag tcattcctcc ccaggattac gagttcctgt tcgaagttgg agttagtaac     2160

gtgtttggcc ccggtacccg tatccctaag gccgcagtgc aggtactgga cgacatcgag     2220

aagtgcttag agaagaagca gcagtctgtc                                      2250


<210>  144
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       T598A mutation

<400>  144
atgcttaggg caaagaacca actatttttg ctgagtccgc attaccttag gcaggttaag       60

gaaagtagtg gctcccgtct gattcagcaa aggctactgc accagcagca gccactgcac      120

cctgagtggg ccgcgttggc gaagaaacag ctgaagggca agaatccaga agaccttata      180

tggcacaccc ccgagggcat ctcaatcaaa ccgttatatt cgaagaggga taccatggat      240

ttgcccgagg agctgcccgg cgtcaagccc tttactaggg ggccttatcc gacaatgtac      300

acattccgac cttggaccat tcgtcagtac gcgggtttct ctacagttga agagagcaac      360

aagttttata aggacaatat caaggcgggc cagcaggggc tgagtgtcgc ctttgatctc      420

gctacacacc gaggatacga tagtgacaac cccagggtta ggggcgatgt tgggatggct      480

ggagtggcca ttgatacagt agaggatact aaaatcctct ttgacggcat acccctggaa      540

aaaatgagtg tctccatgac tatgaatgga gcagtaatcc cagttttagc aaatttcatt      600

gttacgggag aggagcaggg ggtgcccaaa gagaagctga ctggcacaat ccagaacgat      660

atattaaagg aatttatggt gaggaatacg tacatcttcc ctcccgagcc ttcaatgaaa      720

atcattgcag acattttcga gtacacagct aagcacatgc ccaagttcaa ttccatttcc      780

atctcaggct accacatgca ggaggcaggc gccgatgcca tcttggagct ggcctatacg      840

ttggccgacg gcttggaata ttcccgcacc ggactccagg ccgggctaac cattgatgaa      900

ttcgccccaa ggctgtcatt tttctggggt atcggaatga acttttacat ggagatagct      960

aagatgagag ctggtcgacg cttgtgggct catttgatag agaagatgtt ccaacctaaa     1020

aattccaagt ctctcctgct gcgcgcccat tgccagactt cgggttggtc tctgaccgag     1080

caggacccct acaataatat tgtgaggaca gcaattgagg ccatggctgc tgtttttggc     1140

gggacacagt cccttcacac aaactcattt gatgaggccc tgggcctgcc caccgtgaag     1200

tcagcacgca ttgcaagaaa cacccagatt atcatacagg aagaatccgg tatccccaag     1260

gtcgccgacc cgtggggcgg tagctacatg atggagtgct tgacaaacga cgtatacgac     1320

gccgccctga aactgattaa cgaaattgaa gagatgggcg ggatggctaa ggccgtagcc     1380

gaaggtattc ccaaactgag aatcgaagaa tgcgccgcta gaaggcaggc acgcatcgac     1440

tccggttctg aggtcatcgt gggggtgaac aagtaccagc ttgagaagga ggacgctgtt     1500

gaggtcctgg ctatcgataa cacgtcagtg agaaatagac aaatcgagaa gctcaagaaa     1560

attaaatcca gccgcgatca ggctcttgcc gagaggtgcc ttgccgcact cacagagtgt     1620

gccgcctcag gcgacgggaa tatattggca ctggcggtgg atgcaagcag agcgagatgc     1680

actgtcggtg aaatcacaga cgcacttaag aaggtctttg gggaacacaa ggcaaacgat     1740

cgcatggtct ccggggccta tcggcaggag tttggagaat caaaggagat tgcctccgcc     1800

atcaagagag tgcataaatt catggaacga gagggtaggc ggcctaggct gctggtggca     1860

aagatgggcc aggacggaca tgatcggggt gccaaggtta ttgcgacggg ctttgcggat     1920

ctgggatttg atgtcgacat cggcccactc tttcagactc ctcgcgaggt cgcccagcag     1980

gctgtggatg cggacgttca cgctgtcggg atctcaacac tcgctgccgg ccacaagacg     2040

ttagtgcctg aattaattaa agaactgaat agcttaggcc ggccagacat attggtgatg     2100

tgcggtggcg tgattcctcc ccaggactat gaatttctct ttgaggtggg ggtctcgaat     2160

gtgttcggcc caggcaccag gatccctaag gctgcagttc aggtgctcga tgatatcgag     2220

aagtgcctag agaagaaaca gcagtcggta                                      2250


<210>  145
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       T598A mutation

<400>  145
atgttacgcg ccaaaaatca gcttttctta ctttcacccc attacctgcg ccaggtcaaa       60

gaaagctccg gatctcgact tatccagcaa agactacttc atcagcaaca gccgttgcac      120

cccgaatggg cagccctagc aaaaaagcag ctcaaaggga aaaaccctga ggaccttatc      180

tggcatactc ccgaaggaat ctcaatcaag cccctctact ctaaaaggga taccatggat      240

ctgcccgaag agttgcctgg ggttaaaccc ttcactcgag ggccataccc cactatgtac      300

acatttcgtc cgtggactat ccgacaatat gccgggtttt ctacggtaga agagagtaat      360

aagttttaca aagacaatat taaggccggt cagcaggggt taagcgtggc gttcgactta      420

gctacgcatc gcggctatga ctccgacaac ccccgggtta ggggggacgt gggcatggct      480

ggcgttgcaa tcgataccgt ggaagatacc aaaattcttt tcgacggaat acctttggag      540

aaaatgagcg tctctatgac catgaacgga gcagtgattc ccgtgcttgc caatttcatc      600

gtcactggcg aagaacaagg ggtgcccaag gaaaaattaa ctggcacaat ccaaaacgac      660

atcctgaagg aattcatggt gcggaacacc tatatctttc cacctgagcc tagtatgaag      720

atcatcgccg acatcttcga atatactgct aagcatatgc ccaagttcaa cagtatttca      780

atatcgggat atcacatgca ggaggcaggt gccgacgcca tcctggaact ggcctacaca      840

ttggctgacg ggctggaata ctccagaacc gggctgcagg cgggtctgac catcgacgag      900

tttgctcctc ggttatcttt tttctgggga atcggaatga atttctatat ggagatagct      960

aaaatgcgcg ccgggcgaag actctgggcc cacctgatcg aaaaaatgtt ccagcccaaa     1020

aatagtaaga gtctccttct ccgggcgcac tgtcagactt caggatggtc gctcaccgag     1080

caagatccat acaataatat tgtccggacc gctatcgagg ctatggcagc agtttttggc     1140

ggaacccagt ctctgcacac aaattccttc gatgaggctt tgggactccc aacagtgaag     1200

agcgccagaa tagcacggaa cactcaaatc attatccagg aggaaagtgg tatcccaaaa     1260

gtcgcggatc catggggcgg aagttacatg atggaatgcc tcaccaatga cgtatacgac     1320

gccgccctca agctgataaa cgagatcgag gagatggggg gtatggctaa ggccgttgca     1380

gagggcattc ctaaacttag aatcgaggaa tgcgccgcta gacggcaggc gagaattgac     1440

tcaggttctg aggtgatcgt gggcgtgaac aagtatcaac ttgaaaagga ggatgccgtg     1500

gaagtgctgg ccatagataa tacctccgtc aggaaccggc agatcgagaa gttgaagaag     1560

atcaaaagca gccgggacca ggccttggct gaacgctgcc tcgctgcact gaccgaatgc     1620

gctgcatctg gcgacggaaa tatcctcgcc cttgcggtcg acgcatcgcg ggctcgctgt     1680

acagtgggag aaatcactga cgcgctgaaa aaggtctttg gtgagcacaa agcgaatgat     1740

cgaatggtgt ccggagctta taggcaggag tttggtgagt ctaaggaaat agccagtgcg     1800

attaagagag ttcacaaatt tatggagcgg gaggggcgcc gcccccgcct gctcgtcgca     1860

aagatgggcc aggacggcca cgatcggggt gcgaaagtga tcgcgaccgg cttcgccgat     1920

ttgggctttg acgttgacat agggcccctg ttccagacac caagagaggt cgcgcagcag     1980

gcagtagacg ccgatgtgca tgctgtcggt atcagtactc tagctgctgg acataaaacc     2040

ttagtgcctg agctgatcaa ggaacttaac agtctcggaa ggcctgatat cctggtgatg     2100

tgtgggggtg tgatcccacc tcaagactat gaattcctgt tcgaagtcgg cgtgtcaaac     2160

gtgtttggcc cagggacgcg gataccaaaa gccgcagtgc aggtcctgga tgacattgag     2220

aaatgtctgg agaaaaagca gcagagtgtg                                      2250


<210>  146
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       T598A mutation

<400>  146
atgctcaggg ccaaaaacca gctttttctc ctctctccac attacctgcg acaggtgaaa       60

gaatcaagcg gttcaaggct gatccagcag cgcctgcttc accaacaaca gccacttcac      120

ccggaatggg ccgctctggc caagaaacaa ctcaagggga aaaacccaga ggacctcatc      180

tggcatactc ccgagggaat ctctattaag cctctttact ccaagaggga taccatggat      240

ctgcctgaag agctgccagg agtgaagcca ttcacccgag gaccttatcc gacaatgtat      300

acattccgcc cttggacgat ccggcagtac gctggcttca gtaccgtgga ggagagcaac      360

aagttctaca aggataacat taaggctggc cagcagggac taagcgtagc tttcgacctc      420

gccactcata ggggttacga cagcgacaat ccgagagtca gaggggacgt tggcatggct      480

ggcgtcgcca tcgataccgt ggaggatacc aagattcttt tcgatggaat cccactagaa      540

aagatgtccg tgtcaatgac aatgaatggc gctgttatcc ctgtgcttgc aaacttcatc      600

gtcacagggg aagaacaggg ggtgcctaaa gagaagctta ctggcacaat ccagaacgac      660

atactcaaag agtttatggt tcggaatacc tatattttcc ctcccgaacc ttcgatgaag      720

attatcgctg acattttcga gtatactgcc aagcacatgc ctaaatttaa ctccatctct      780

attagcggct atcacatgca agaggccggt gccgatgcca tcctagagct ggcctacact      840

ctcgccgacg gcctggagta ctcacgcact ggtctgcagg ctggcctaac catcgatgaa      900

ttcgcaccca ggttgagttt tttctgggga atcgggatga atttctatat ggagatagca      960

aagatgcgcg ctgggcggag actgtgggcc cacctgatcg aaaagatgtt tcaacccaag     1020

aactcaaaaa gcctattgct ccgcgctcac tgtcagactt ctggatggag tttgactgag     1080

caagacccgt ataacaacat tgtgagaaca gcaattgagg ccatggccgc tgtcttcgga     1140

ggcacacaat ccctccatac aaattccttt gatgaggcgc tcggcctccc aacggtgaag     1200

agtgcacgaa ttgcccgtaa tactcagatc attattcaag aggagagtgg aatcccaaag     1260

gtagcggacc cctggggggg ttcatacatg atggagtgtc tcaccaacga cgtgtatgac     1320

gcagccctga aactgatcaa cgagatagag gagatgggag gaatggccaa ggctgtggct     1380

gagggaatcc caaagctgag aatcgaagag tgcgccgcac gaagacaggc cagaatcgac     1440

agcggttcag aagtgattgt gggagtgaac aaatatcagc tcgagaaaga agatgccgtc     1500

gaggtcttgg ccattgacaa tacttctgtg agaaatagac aaatcgagaa acttaagaaa     1560

atcaagtcaa gtagggacca ggccctcgcg gagcggtgtc tcgcagccct gacggagtgc     1620

gccgccagcg gcgacgggaa catcctcgcg ctggccgtgg atgcatccag agctcgctgt     1680

accgtgggcg aaattactga tgcactcaaa aaggtctttg gggaacacaa agcaaacgac     1740

cgcatggtct ctggagccta ccgccaagag tttggcgaga gcaaagagat agcatctgcc     1800

atcaagaggg tgcacaaatt catggagcga gaagggagga ggccccgctt gctcgttgcg     1860

aagatgggac aggatggcca cgaccgtggc gctaaagtaa ttgccaccgg gtttgccgac     1920

cttggctttg atgtggatat cgggccactg ttccagactc ctcgcgaggt agcccagcag     1980

gccgtggatg cggacgtcca cgcagttgga attagcacct tggcggcggg ccacaagact     2040

ctggtacctg aacttatcaa ggaactgaac tctctgggtc gtccagatat tctggtcatg     2100

tgcggcgggg tgattcctcc gcaggactac gaatttctat ttgaggtcgg ggtttccaac     2160

gtctttgggc cgggcactag gataccaaag gccgctgtcc aggtgcttga cgatatcgag     2220

aaatgcctgg agaagaagca gcagagtgta                                      2250


<210>  147
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       T598A mutation

<400>  147
atgctgaggg caaagaatca gctgttcctg ctgtcccctc actacctccg tcaagtgaag       60

gagagctctg gttcgcggtt aattcagcag agactgcttc atcaacagca acccctccac      120

cccgaatggg ctgccctggc caagaaacag ctcaaaggta agaaccctga ggacctgatc      180

tggcacacac ctgaagggat cagcatcaag cctctctact ccaagcgcga cactatggat      240

ctgccagagg agctccctgg cgtaaaacca ttcacccggg gaccctatcc tacaatgtac      300

acctttcggc cttggactat cagacagtac gctgggttct ctacagtaga agagagcaat      360

aagttttaca aggataatat aaaagctggt cagcagggcc tcagtgtagc cttcgaccta      420

gctacacaca gaggatatga ttccgataat ccgagagttc ggggagatgt cggcatggcc      480

ggagtggcaa tagacaccgt ggaagatact aagatcctgt tcgatggcat tccgctcgaa      540

aaaatgagtg tcagcatgac tatgaacggc gctgtgatcc ccgtgcttgc aaactttatc      600

gtaaccgggg aggaacaggg tgtgccaaaa gagaaactca caggaacaat tcagaacgat      660

attcttaagg agttcatggt cagaaacaca tacattttcc cacccgagcc ttcaatgaaa      720

atcatcgccg acatattcga gtacaccgct aaacacatgc caaaatttaa ttcaattagt      780

atcagtgggt atcatatgca ggaggcaggc gccgacgcta ttctggagct ggcttacacc      840

ttggccgatg gtctggaata ttcacgcacc gggctgcaag ctgggttgac catcgacgaa      900

tttgcaccac gtctgtcctt cttttgggga attggcatga acttttacat ggagattgca      960

aagatgcggg caggacggag gctctgggcc catctcattg agaagatgtt tcagcccaaa     1020

aactccaaat ctttactgct gcgcgcccac tgccagactt cgggctggtc gctgaccgaa     1080

caagatcctt acaacaacat agttcggacc gcaatcgaag ctatggctgc cgtgttcggg     1140

ggcacgcagt ctctccacac taactccttc gacgaagccc taggtcttcc aacagtgaag     1200

tccgctagaa ttgcccgaaa tacccagatc attattcaag aggaatctgg aatccctaag     1260

gtcgctgacc cttggggcgg tagctacatg atggagtgtc tgaccaacga cgtgtacgat     1320

gccgcactaa agctcatcaa tgagatagaa gagatggggg gaatggctaa agctgtagca     1380

gaaggcatcc ccaagctgcg gatagaagaa tgtgcggcac gcagacaagc ccgcatagac     1440

agtgggtccg aagtgatcgt gggtgtaaat aagtaccagc tcgagaaaga ggatgcggtg     1500

gaggtactgg ccattgacaa tacaagtgtc aggaaccgac agattgagaa gctgaagaaa     1560

attaaatcct ctagggacca ggccctggct gaaaggtgtc tggcggcatt gaccgaatgc     1620

gcagcaagcg gcgacggaaa catactggca ttggcggtag acgcaagccg tgctcgatgt     1680

actgttggcg aaatcactga tgcgctcaag aaggtttttg gcgagcacaa ggctaatgat     1740

cggatggtct ctggggccta cagacaggaa tttggagaat ccaaggagat cgctagcgca     1800

attaaaagag ttcacaaatt tatggagcgc gagggaagga gaccccggct gctcgtcgca     1860

aagatgggcc aagacggcca tgatcgcggc gcaaaagtca tcgcaacggg ctttgccgat     1920

ctcgggtttg atgtcgatat tggcccactg ttccagacac ccagggaagt ggctcagcaa     1980

gccgtcgatg ccgatgttca cgccgtgggc atctcaacac tagctgccgg ccataagaca     2040

ctagtaccag aactgatcaa ggaactgaat tctcttggta gacccgacat cctcgtgatg     2100

tgtggcgggg ttatcccgcc gcaagactac gagtttcttt ttgaggtcgg tgtgtcgaat     2160

gtcttcggac ccggcactcg gattcctaaa gctgcagtgc aagtgttgga cgacatcgag     2220

aagtgcctgg aaaagaagca acagagtgtt                                      2250


<210>  148
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       T598A mutation

<400>  148
atgctgagag caaaaaatca gctcttcctg ctgtcacccc actatctgcg acaggtaaaa       60

gagtctagcg gttccagact cattcagcaa cgcttgcttc accagcagca gccgctccac      120

cctgaatggg cagccctggc aaagaagcag ctaaaaggta agaatccaga ggatctgatc      180

tggcacacac ccgaggggat ctccattaag cccctatact ctaagagaga cactatggac      240

ttacctgaag aactgccagg tgtgaagcct tttaccagag ggccatatcc taccatgtat      300

acattccgac catggactat ccgtcaatat gcggggttca gcaccgtaga ggagtcaaac      360

aaattttata aggataatat caaagctgga cagcagggcc tgtccgtcgc attcgatcta      420

gcaacacaca gaggatatga ttcagacaat cctcgggtgc ggggggacgt cggaatggcg      480

ggggtcgcca tcgacaccgt ggaggacacc aagatactct tcgatggcat tcccctcgaa      540

aaaatgtccg tgtctatgac catgaacggc gcggtcattc ctgtgctggc taactttatc      600

gtaaccggag aagagcaggg cgtgccaaaa gaaaagctga ctggaacaat ccagaatgat      660

atcttgaaag agttcatggt gcggaacaca tacatcttcc caccggaacc ttcaatgaag      720

atcattgctg atattttcga atacactgca aaacacatgc ccaaattcaa tagcataagt      780

ataagcggat atcacatgca ggaggctgga gccgacgcca ttcttgaact ggcgtatacc      840

ctggcggacg gattggaata tagcagaaca ggactacagg cagggttgac catcgacgag      900

ttcgccccaa ggctgagttt cttctgggga attgggatga atttttacat ggagattgcc      960

aagatgcgcg ccggtcgtcg actctgggca catcttatcg aaaagatgtt ccagcccaag     1020

aatagcaagt cactgctcct gagagcgcac tgccaaacgt ctggctggag cttgactgag     1080

caggacccct acaataatat cgtgagaacg gctatcgaag ctatggccgc tgtttttggg     1140

ggcactcagt ctctgcacac aaacagtttt gatgaagcac tcggcctccc aaccgtcaag     1200

tcagcaagga tcgccaggaa cacccaaatc ataatacagg aagagagcgg catccccaaa     1260

gtggcagatc catggggggg aagctatatg atggaatgct tgacaaatga cgtgtacgat     1320

gcagccctga aactgattaa cgagattgag gaaatgggtg ggatggctaa agccgtagcc     1380

gagggcattc caaaactgcg catagaggaa tgtgcagcta ggaggcaggc tagaatagat     1440

agcggcagtg aggtcatcgt tggtgtcaac aagtaccagc tggaaaagga agatgccgtt     1500

gaggtcctgg ctattgacaa cacctcggtc agaaatcggc agatagagaa gctgaagaag     1560

ataaagagta gtagagatca agcccttgcc gaacgttgcc tcgccgccct gaccgagtgc     1620

gccgcttcag gcgatggaaa tattcttgca cttgcagtgg acgccagtag ggctagatgt     1680

accgtgggtg agatcacgga cgctctcaag aaagtgtttg gcgagcacaa ggccaatgac     1740

cggatggtgt ctggcgcgta tagacaggag ttcggagaat caaaagagat cgcctctgcc     1800

attaagaggg tgcacaaatt tatggagaga gagggccggc gcccccgact gttggtggca     1860

aaaatgggac aggatggaca tgacagaggc gcaaaagtca ttgccaccgg atttgccgat     1920

ctgggctttg acgtggacat tgggccgttg tttcagactc cgagggaggt cgctcagcag     1980

gccgtggatg ctgacgttca tgccgtggga atcagcaccc tggccgccgg acataaaacc     2040

ctcgtgccag agctgataaa agaacttaac tccctgggcc gtcctgatat cctggtgatg     2100

tgcggtggcg taattccccc tcaggattac gagttcctct tcgaggtggg cgtctccaat     2160

gtgtttggcc cggggacccg tatcccgaag gccgcagttc aggtgttgga tgacattgag     2220

aaatgcttag agaagaagca gcagagcgta                                      2250


<210>  149
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       T598A mutation

<400>  149
atgctgcggg caaagaacca actcttcctc ctaagcccgc attacctgag gcaggtcaag       60

gagagttccg gctctcgttt aattcaacag cggctgctgc accagcagca gccattacac      120

cctgagtggg cggcgctagc aaagaaacag ttgaagggaa agaaccctga ggatctgatc      180

tggcacaccc ctgaggggat ttccatcaag ccactctatt ctaagcggga cactatggat      240

cttccagaag aactgcccgg cgtaaagccc ttcacccgcg gcccttaccc taccatgtac      300

accttccgac cttggaccat caggcagtac gcaggattct caactgtgga ggaatctaac      360

aaattttaca aggacaacat aaaggccgga cagcaggggt tatctgtcgc cttcgacctg      420

gccacacacc gagggtacga ctctgataac ccgagagtac gcggggacgt gggaatggct      480

ggagtcgcaa tcgacacagt ggaagacacc aagatcctgt tcgatggcat cccactggaa      540

aagatgagtg tcagcatgac aatgaatgga gccgttattc ctgtgctggc taactttatc      600

gtgacgggag aggagcaggg ggtgccgaag gaaaagctga cgggtaccat ccagaatgac      660

atcctgaagg aattcatggt gcggaatact tatatttttc ctccagagcc atccatgaag      720

atcatcgctg acatcttcga atacaccgcc aaacatatgc cgaagtttaa cagtatctct      780

atctctgggt accacatgca ggaggccggg gcagacgcta tcttagagtt ggcctataca      840

cttgcagacg ggcttgaata tagcaggact gggctgcaag ccgggctgac cattgacgaa      900

tttgcgcccc gcctgtcttt tttttggggg attgggatga acttctatat ggagattgca      960

aaaatgagag ctggcaggcg cctatgggcg cacctgatcg aaaagatgtt ccagccaaag     1020

aattctaagt ctcttctcct gagagcccac tgtcagacca gtggttggtc cttaaccgag     1080

caggacccat acaataatat agtacgtaca gctattgaag ccatggccgc ggtgtttggc     1140

ggaacacaga gcctccacac caacagcttt gacgaggccc tgggcttacc aaccgtcaaa     1200

tccgcaagga tcgccaggaa tacacagatt attatacagg aggaaagtgg cattcctaag     1260

gtggcagatc cctggggcgg ttcttacatg atggaatgcc tgacaaatga tgtctacgat     1320

gccgccttga aactgatcaa tgaaatcgaa gagatgggtg gcatggcaaa agctgttgca     1380

gagggaattc ctaagctgcg gattgaagaa tgtgcagctc gccggcaggc tagaatcgac     1440

tccggtagcg aagtcattgt tggagtcaac aagtaccagc tagagaaaga ggacgcagtc     1500

gaggtgctgg ccattgacaa cactagcgtg cggaatagac agatcgagaa gctgaaaaaa     1560

ataaagtcct cacgcgatca ggcgctggca gaacggtgct tagcagctct taccgagtgc     1620

gcagcctccg gcgatggaaa catcctcgcc ctagcggtgg acgcttcgcg tgcaaggtgc     1680

acagttggcg aaataacgga cgcgctgaag aaagtattcg gcgaacataa agctaatgat     1740

aggatggtct caggtgcata tagacaggag ttcggggaat caaaagaaat tgcttccgca     1800

attaaaaggg tgcataaatt tatggaacga gagggaagac ggcctcgatt actagtcgcc     1860

aagatgggac aggatggcca cgaccgaggg gccaaggtca tcgctacggg gttcgcagat     1920

ctcggctttg atgttgatat cggaccactg ttccagaccc ctcgagaggt cgcccagcag     1980

gccgtcgatg ccgacgtcca cgcagtgggc atatccacgc tggcagctgg gcataaaact     2040

ctcgtccccg agcttatcaa agaactgaac tcactgggcc gacccgacat tctggtgatg     2100

tgtgggggcg taatcccacc tcaggattac gagtttcttt ttgaagtggg agtaagcaac     2160

gtcttcgggc cagggaccag gattccaaag gcggctgtcc aggtgctgga cgacatagag     2220

aagtgtttag aaaagaaaca gcagagtgtt                                      2250


<210>  150
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       T598A mutation

<400>  150
atgcttcgag ccaagaatca gctcttcctc ttgagcccac actatctgag gcaggtcaag       60

gagtcatctg ggtctcggtt gattcagcaa cgccttctgc accagcagca gccgctccat      120

cccgagtggg ccgccctggc caaaaaacaa ctcaagggaa aaaatccaga ggatttgatc      180

tggcatacac ccgaagggat ctccataaag cctttgtata gtaagcgcga cacaatggat      240

ctcccagagg agctgcctgg tgtaaaacct ttcaccagag ggccctaccc caccatgtac      300

acctttagac cgtggacaat cagacagtac gctgggttct caacagtgga agagtccaac      360

aagttttaca aagataacat caaagcgggc cagcaggggc tcagcgtggc cttcgactta      420

gccacccacc gagggtatga cagcgataat ccgcgtgttc gcggggatgt cgggatggcc      480

ggcgtggcca ttgacaccgt ggaagataca aagatcctat tcgatggaat cccactggaa      540

aagatgagcg tctctatgac tatgaacgga gctgttatcc cagttctggc aaacttcata      600

gtaactggtg aagaacaggg cgtgcctaaa gagaagttga cagggactat ccagaacgac      660

atcttgaagg agttcatggt gaggaacacg tacatttttc cacctgagcc atcaatgaag      720

attatcgctg acatattcga atataccgca aagcacatgc ctaagttcaa ctcaatttcc      780

atctcaggct accacatgca ggaggccggc gcggacgcta ttctggaatt ggcttatacc      840

ctcgcggatg gactcgaata ttcgcggaca ggcctccaag ccgggttgac catcgatgag      900

tttgcaccca gactcagctt cttttggggc atcggaatga acttctatat ggagatagca      960

aagatgaggg caggccggcg gctgtgggcc catctgatcg agaagatgtt tcaaccgaag     1020

aacagtaaaa gccttctcct cagagcacac tgccaaacca gcggttggtc cttaacagaa     1080

caggatcctt ataacaatat tgtgaggacc gccattgagg ctatggccgc agtctttggc     1140

ggtacgcaga gcctccatac caatagcttt gacgaagctc ttgggcttcc tacagtgaaa     1200

agcgcccgga tcgcaaggaa cacccagatt atcatccagg aagagagtgg catacccaaa     1260

gtggctgatc cttggggagg aagctatatg atggagtgcc tcaccaacga tgtgtacgat     1320

gcagccttga agttgatcaa cgagatcgag gaaatggggg gcatggctaa ggctgttgcc     1380

gaaggtatcc caaaacttag gatcgaggaa tgcgctgcac gccgtcaggc tagaatcgac     1440

agtggtagcg aggtgatcgt gggcgtgaac aagtatcagc tcgagaaaga agatgcagtc     1500

gaggtgttag caatcgacaa taccagcgtc cggaaccgac agattgaaaa actaaagaaa     1560

attaagtcct caagagatca ggccttggct gagagatgtc ttgccgctct cacagagtgt     1620

gccgcttcag gggatggaaa tattctcgca ctggccgtgg atgcctctag agctagatgt     1680

accgtggggg aaatcaccga tgcattgaag aaggtctttg gggagcacaa agcaaacgac     1740

cggatggtta gcggcgccta tcgccaggag ttcggcgaat caaaggagat tgcctcagcc     1800

atcaaacgtg tacataaatt catggagagg gaaggtcggc gcccacgtct cctggttgcc     1860

aagatgggtc aggatggcca tgaccggggg gcgaaagtga tcgcaacggg ctttgccgat     1920

ttaggcttcg atgtggatat cggacccttg tttcagaccc ctcgtgaagt ggcacaacag     1980

gccgttgacg ccgatgtaca cgccgtcggc atcagcaccc tggccgcagg ccacaagaca     2040

ctggtccccg agttaattaa ggagctcaac tcactcggga gaccagatat tttggtgatg     2100

tgcggagggg tgattccccc gcaggattac gagtttctgt tcgaggttgg agtgtccaat     2160

gtgtttggcc ctggcaccag gattccaaag gccgccgtac aggtgcttga tgatatcgag     2220

aagtgcctgg aaaagaagca acaatcggtt                                      2250


<210>  151
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  151
atgctgagag ccaagaacca gctgttcctg ctgagccctc actacctgag acaggtaaag       60

gagagcagcg gctcaaggct gatccaacag aggttgctgc accagcagca gccccttcat      120

cccgagtggg cagctctggc caagaaacag ttgaagggca agaaccccga ggacctgatt      180

tggcataccc ccgagggcat cagcatcaag cctctgtact ccaagcgcga caccatggac      240

ctccccgagg aactgcccgg ggtgaaacca tttacacgcg gcccctaccc caccatgtac      300

accttccggc catggacgat taggcagtac gctggcttca gcacggtgga ggagagcaat      360

aagttctaca aggacaacat caaggcaggg cagcaggggc ttagcgtggc ctttgacctg      420

gccacacacc gggggtacga cagcgacaat cccagggtgc ggggcgacgt tggcatggcc      480

ggcgttgcta tcgataccgt ggaggatacg aagatactgt ttgacgggat ccccctggag      540

aaaatgagcg tgagcatgac aatgaacggc gctgtgatcc ctgtcctcgc taacttcatc      600

gttaccggcg aggaacaggg agtacctaag gaaaagctga ctggaactat tcagaatgac      660

attctcaagg aattcatggt caggaacact tatatctttc cccctgaacc gtctatgaaa      720

atcatagcag acatttttga gtataccgcc aagcacatgc ccaagtttaa cagcatctcc      780

atctctggct accacatgca ggaggcaggc gccgacgcta ttctggagct ggcgtacact      840

ctcgccgacg gactggagta ctctcgcact ggactccagg ccgggctgac catcgatgag      900

ttcgcaccga ggctgtcctt cttctggggc attggaatga acttttacat ggagatcgct      960

aagatgcgag caggccggag actgtgggcc cacctgattg aaaaaatgtt ccaacctaag     1020

aattccaaga gcctgctgtt gagagcccac tgccagacca gcggctggtc gctgaccgag     1080

caggacccct acaataacat agtgcggacc gctattgaag ccatggccgc cgtttttggc     1140

ggcactcaga gcctgcacac caacagcttt gacgaggccc tgggcctgcc cactgtgaag     1200

agtgccagaa tcgccaggaa tacccagatt atcattcagg aggagtcagg aatacccaaa     1260

gtggccgacc cctggggggg tagctacatg atggagtgcc tgacaaacga cgtgtacgat     1320

gccgccctca agctgatcaa cgagatcgag gaaatgggcg gcatggccaa ggctgttgcc     1380

gaaggcatcc ccaagctccg gattgaagag tgtgcggcca ggagacaggc taggatagac     1440

agcggcagcg aagtgatcgt cggcgttaac aaataccagc tggaaaagga agatgctgtg     1500

gaggtgctgg ccatcgacaa cacctccgtt cggaacagac aaatcgagaa gctgaagaaa     1560

atcaagagca gcagagacca ggcccttgct gagcgctgtc tggccgcact aaccgaatgc     1620

gccgccagcg gcgatgggaa tatcctggcc ctggccgtgg acgcttctag ggcaagatgc     1680

acagtgggcg agatcacaga cgctctgaag aaggtcttcg gcgagcataa agccaacgac     1740

cggatggtga gcggagcata ccggcaggag ttcggcgaga gcaaagaaat tacctctgcc     1800

atcaaacgcg tgcataagtt tatggagcgg gagggcagga gaccgcggct gttggtggcc     1860

aaaatgggac aagatggcca cgatcgcggt gccaaggtga tcgccaccgg gttcgctgac     1920

ctgggcttcg acgttgatat aggccctctt ttccagacac ctcgggaggt ggctcaacag     1980

gctgtggatg ccgacgtcca cgcagtgggc gtgagcaccc tggccgccgg ccacaagacc     2040

ctggtgcccg agttaatcaa ggagttgaat tcactgggca gacctgacat cctggtgatg     2100

tgcggcggcg tcatcccccc gcaggattac gagttcctgt tcgaggtggg agtgagcaac     2160

gtgttcggtc ctggcacacg gatccccaag gccgccgtcc aggttctgga cgacatcgag     2220

aagtgcctgg aaaagaaaca gcagtccgtg                                      2250


<210>  152
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  152
atgctgagag ccaaaaatca gctcttccta ctgagccctc attacctgag gcaggtgaag       60

gagagctcag ggagccggct catccagcag agactgctcc atcagcagca gccgctgcac      120

ccggagtggg ccgccctggc caagaaacaa ctgaagggca agaacccaga ggaccttatt      180

tggcacaccc cagagggcat tagcatcaag cctctctata gcaagagaga caccatggac      240

ctccccgagg agctgcccgg cgtgaagcct ttcacccgtg gcccctaccc aaccatgtac      300

acattcaggc cctggactat ccggcagtac gcgggcttct ctaccgtgga ggagtccaac      360

aagttctaca aggacaatat taaagctggc cagcagggac tgagcgtggc cttcgatttg      420

gccacccaca gaggatacga cagcgacaac cccagggtga ggggcgacgt tggaatggcc      480

ggcgtggcca ttgatactgt cgaggacacc aagatcctgt tcgatgggat acccctcgaa      540

aaaatgtctg tgtccatgac aatgaatggg gccgtgatcc cagtgttggc caattttatc      600

gtgacaggag aggagcaggg cgtgcccaag gagaagctga ccggcaccat ccagaacgac      660

atcttgaaag aattcatggt tagaaatacc tacatctttc ctcccgaacc cagcatgaag      720

atcatcgccg atatcttcga gtataccgcc aaacacatgc ccaaattcaa ctccattagc      780

atatccggat accatatgca ggaggctggc gccgacgcca tcctggagct ggcgtacacc      840

ctggccgatg gcctggaata ttctaggacc ggcctgcagg ctggactcac aatcgatgag      900

ttcgcccccc gcctgagctt cttctggggc atcggcatga acttctacat ggagatcgct      960

aagatgagag cgggacgccg cctgtgggct cacctgatcg aaaaaatgtt ccaacctaag     1020

aatagcaagt ctctgctcct gcgggcacac tgtcaaacct ccggctggtc ccttacagaa     1080

caggacccgt acaacaacat cgtgagaacc gccatcgaag ccatggcggc cgtgttcggg     1140

ggcacccagt cactccacac caatagcttc gacgaggccc tgggcttgcc tactgtcaag     1200

tctgccagga tcgccaggaa cactcagatt atcatccagg aggagagcgg cattcctaag     1260

gtagctgacc cctggggggg aagctacatg atggaatgcc tcaccaacga cgtgtacgat     1320

gccgccctga agctgattaa tgagatcgag gaaatggggg gcatggccaa ggctgtagcc     1380

gagggaatcc ccaagctgag aatcgaggag tgcgccgcca ggcggcaggc ccgcatcgat     1440

agtggcagcg aggtgatcgt gggcgttaac aagtaccagc tcgagaagga agacgccgta     1500

gaggtgttgg caatcgacaa tacctccgtg agaaataggc agatcgagaa gctaaagaag     1560

ataaagagca gccgggacca ggctctggca gaacggtgcc tggccgccct cactgaatgc     1620

gccgcttctg gcgatggcaa cattctggcc cttgccgtcg atgccagccg ggcccgatgc     1680

actgtgggag agatcacaga cgctctgaag aaggtgttcg gcgagcataa agcaaacgat     1740

agaatggtgt ccggcgccta caggcaggag tttggcgaga gcaaggagat cacatctgct     1800

attaagagag tgcataagtt catggagaga gagggacggc ggcctagact gctggtagca     1860

aagatgggcc aggacggcca cgatcgggga gcaaaggtca ttgctaccgg gttcgccgac     1920

ctgggcttcg acgtggacat tggccccctc ttccagaccc cccgcgaagt tgctcagcag     1980

gctgtggatg ctgacgtgca cgctgtgggc gtcagcacac tggccgctgg acataagacc     2040

ctggttcccg agctgatcaa ggagctgaat agcctgggtc ggccagacat cctcgtgatg     2100

tgcgggggtg tgatcccccc tcaggattac gagttcctgt tcgaggttgg agtctctaat     2160

gtgttcggcc ccggaacaag aatcccgaag gccgctgtgc aagtcctgga cgacatcgaa     2220

aagtgcctcg agaagaagca gcagtctgtg                                      2250


<210>  153
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  153
atgctgaggg ccaagaacca gctgttcctc ctgtctcctc actacctgag acaggtgaag       60

gagtccagcg gtagcagact gatccagcag aggctgcttc accagcagca gcccctccat      120

ccggagtggg ctgcactggc aaaaaagcag cttaagggaa aaaaccccga ggacctgatt      180

tggcacaccc cagagggaat tagcattaaa cccctctaca gcaaacggga cacgatggac      240

ctgcccgagg aactgcccgg cgtgaagccc ttcacacggg gcccataccc cacaatgtat      300

acattccgtc cttggaccat tcgccaatac gccgggttca gcacggtgga ggaatccaac      360

aagttctaca aggacaacat caaggccggc cagcaaggcc tcagcgtcgc ctttgacttg      420

gccacccaca gaggctacga ctccgacaac cccagagtga gaggcgacgt gggtatggcc      480

ggcgtggcca tcgacactgt tgaggacacc aaaatcctat ttgacggcat acccctggaa      540

aagatgtccg tgagcatgac aatgaatggc gctgtgatcc ccgtgctcgc taacttcatc      600

gtgaccggcg aggagcaggg tgtccctaag gagaaactta ccggcacaat ccagaacgac      660

attctcaagg agtttatggt gcgcaacacc tacattttcc ccccagagcc tagcatgaag      720

atcattgccg acatcttcga gtacaccgcc aagcatatgc caaagtttaa ctccatttca      780

atctctggct accatatgca ggaagctggc gctgacgcca tcttagagct ggcctacacc      840

ttggccgacg gcctcgaata cagcaggacc ggccttcagg ccggtctgac cattgacgaa      900

tttgcaccca gactgagctt cttctggggc atcggcatga acttctatat ggagatcgct      960

aaaatgagag ccggccggag actgtgggct cacctgatcg agaaaatgtt tcaacccaag     1020

aactccaaaa gccttctgct cagggcccat tgtcaaacct ctggatggag cctgactgag     1080

caggacccgt ataacaacat cgtcaggacc gccatcgagg ccatggctgc ggtgtttggc     1140

ggaacccagt ccttacacac aaatagcttt gacgaagccc tggggctgcc aaccgtgaaa     1200

agcgccagaa tcgcccggaa tactcagata atcatccagg aggagtccgg gatccccaag     1260

gttgccgacc cctggggggg aagttacatg atggagtgct tgaccaacga tgtgtacgat     1320

gctgctctga agctgattaa cgagattgag gagatgggag gcatggctaa ggctgtcgcg     1380

gagggcatcc ctaagctgag aatcgaggag tgcgccgccc gccggcaggc caggattgac     1440

agcggatctg aggtgatcgt gggggtgaac aagtaccagc tggagaagga ggacgccgtt     1500

gaggttctgg ctatcgacaa caccagcgtc agaaacaggc agatcgagaa gctgaagaaa     1560

atcaaaagca gcagagacca ggccctggca gaaagatgcc tggctgccct gaccgagtgc     1620

gctgctagcg gagacgggaa catcctggct ctggccgtcg acgcttccag agccaggtgt     1680

accgtcggcg agatcaccga cgccctgaag aaagtgttcg gcgagcacaa ggccaacgac     1740

cgcatggtgt ccggcgccta caggcaggag ttcggcgagt ccaaggagat tacctccgcc     1800

atcaaacggg tgcacaaatt catggagaga gagggcagac ggccacgctt gctcgtggcc     1860

aagatggggc aggacggcca cgataggggc gctaaggtta tcgctacagg ctttgctgat     1920

ctgggcttcg acgtggacat cggccccctg tttcagaccc ctagagaggt agctcagcag     1980

gccgtcgacg ccgacgtgca cgccgtgggc gtcagcacac tggcagccgg acacaagacc     2040

ctcgtgcccg agcttatcaa ggaactgaac tccttggggc ggcccgacat cctcgtcatg     2100

tgcggcggag tgattccccc ccaggactat gagttcctgt tcgaggtcgg cgtaagcaac     2160

gtctttggcc ccggaactcg gatccccaag gccgcagtac aggtgctgga cgacatcgaa     2220

aagtgcctgg agaagaagca acagtctgtg                                      2250


<210>  154
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  154
atgctgcgcg ctaaaaacca actattcctg ctgtcccccc attacctgag acaggtgaag       60

gagagctccg gaagcaggct gatccaacag agacttctgc accagcagca gcccctgcat      120

cccgagtggg ccgctctggc taagaaacaa ctgaagggaa agaaccccga ggacctgatc      180

tggcacaccc cagagggcat atccatcaag cccctgtatt ctaagaggga cactatggac      240

ctgcccgagg agctccccgg cgtcaagcct ttcacacgcg gaccttaccc cacaatgtac      300

acattccgac catggaccat taggcagtac gcaggattca gcaccgttga ggagtccaat      360

aaattctata aggacaatat taaggccgga caacagggcc tgagtgtggc attcgacctg      420

gccacacaca gaggttacga ctccgataat cctagggtga gaggcgacgt gggcatggct      480

ggagtggcca tcgataccgt cgaggacaca aagatcctgt tcgacggcat ccccttggag      540

aaaatgtccg tgagcatgac catgaacggc gccgtgattc ccgtgctggc caactttatt      600

gtaaccggcg aggagcaggg cgtccccaag gagaagctga ccggcaccat ccagaacgat      660

atcctcaagg agttcatggt acggaatacc tacatttttc cccccgaacc ctccatgaag      720

atcatcgccg acatcttcga gtacaccgcc aagcacatgc ccaagttcaa ctccatcagt      780

attagcggct atcacatgca ggaggccggc gccgacgcca tcctggaact ggcctacaca      840

ctggccgacg gtctggagta cagcagaacc ggcctgcaag caggcctgac catcgacgag      900

ttcgcccctc gactgagctt cttctggggc attggcatga acttttacat ggagatcgcc      960

aaaatgcgcg ctggcaggcg actctgggcc cacctgatag aaaaaatgtt ccagcccaag     1020

aactccaagt ccctgctcct cagggcccac tgtcagacta gcggctggag cctcaccgag     1080

caggacccat ataataacat tgtaagaaca gccatcgagg ccatggccgc agtgttcgga     1140

gggacccaga gcctgcatac caacagcttc gatgaggccc tgggactgcc cactgtaaag     1200

tccgctagaa tagcccggaa cacccagatc attatccagg aagagtccgg gatccccaag     1260

gtggccgacc catggggcgg cagctacatg atggagtgtc tcaccaacga cgtttacgat     1320

gctgccctga agcttatcaa cgaaatcgag gagatgggcg gcatggccaa agccgtcgcc     1380

gaggggattc caaagctccg gatcgaggag tgcgccgcca gaaggcaggc cagaatcgac     1440

tctggaagcg aggtgattgt gggtgtgaat aagtatcagc ttgagaagga agacgctgta     1500

gaggtgctgg ctatagataa caccagcgtc aggaacaggc agattgaaaa gctgaagaag     1560

atcaagtcga gcagagatca ggcgctggcc gagagatgcc tggccgccct gactgagtgc     1620

gccgcctctg gcgatggcaa catcctcgca ctggccgtgg acgctagccg ggcccggtgt     1680

accgtgggcg agataaccga tgccctgaag aaggtgttcg gagagcacaa ggccaacgac     1740

agaatggtgt ctggcgcata tagacaggag ttcggcgaga gcaaggagat tacgagcgcc     1800

atcaagagag tgcacaagtt catggagagg gagggcagga gaccacggct gctggttgcc     1860

aagatgggcc aagacggtca cgacagaggg gctaaagtga ttgccaccgg cttcgccgac     1920

ctgggcttcg acgtggacat cggtccactg ttccagaccc ctagggaggt ggcgcagcag     1980

gccgtggacg ccgacgtgca cgccgtcggc gtgagcacac tggctgccgg ccacaagaca     2040

ctagttcctg agctgatcaa ggaactcaac agcctgggcc ggcctgatat actggtgatg     2100

tgcggggggg tgatcccccc tcaggattac gagtttctgt ttgaggtggg cgtgtccaac     2160

gtcttcggcc ccgggaccag aatcccaaag gccgcagtgc aggtattaga cgacattgag     2220

aagtgcctgg agaagaaaca gcagtccgtt                                      2250


<210>  155
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  155
atgctacgag ctaagaatca gctcttcctg ctgagccccc actacctccg ccaggtcaag       60

gagtcgtcgg ggagccggct cattcagcag cggctcctgc accagcagca gccgctccat      120

ccggagtggg ccgccctggc caagaagcag ctcaagggca agaaccccga ggacctgatc      180

tggcacacac ccgagggcat ctcgatcaag cccctgtatt ccaagcgaga taccatggac      240

ttgcccgagg agctgcccgg tgtgaagccc tttacgaggg gtccatatcc gactatgtac      300

acgtttcggc cttggaccat ccgacaatac gccggctttt ccaccgtgga ggagagcaac      360

aagttctata aggacaatat caaagccggt caacaagggc tgtcggtcgc gttcgacctg      420

gccacccaca ggggttacga ctccgataat cccagggttc ggggggacgt cggcatggcc      480

ggcgtggcaa tcgacaccgt ggaggatacc aagattcttt tcgatggcat ccccctcgag      540

aagatgtctg tctccatgac tatgaacggc gccgtgattc ccgtcctggc gaacttcatc      600

gtcaccgggg aggaacaggg tgtgcccaag gagaagctga ctggtaccat ccagaacgat      660

atcctaaaag aattcatggt ccggaatacc tacatatttc cgcccgagcc cagcatgaag      720

atcatcgccg acatcttcga gtataccgcc aagcacatgc ccaagttcaa ctcgatcagt      780

atcagcggtt atcacatgca ggaggcggga gcagacgcca tcctggagct ggcgtacacc      840

ctggccgacg gcctggagta cagtcgcaca ggactgcagg ctgggctgac aattgacgag      900

tttgccccca ggctctcctt tttctggggc atcggcatga acttttatat ggagatagcc      960

aagatgaggg ccgggaggag gctgtgggcc catctaattg aaaagatgtt ccaacctaaa     1020

aactccaaat ccctcctgct gcgggcccac tgtcagacta gcgggtggag cctcacggag     1080

caagaccctt acaataacat cgtccgcacc gccattgagg cgatggccgc cgtgttcggc     1140

gggacgcaat ctctgcacac caacagcttc gacgaagcgc tgggcctgcc aaccgtaaag     1200

agcgcccgta tagcgcggaa cacccagatc ataatccagg aggagtcggg catccccaag     1260

gtggccgacc cctggggggg cagttatatg atggagtgcc tgacgaatga tgtctacgac     1320

gcggcactga aactcatcaa cgagatcgag gagatggggg ggatggccaa ggctgtcgcc     1380

gagggcatac cgaagctgcg gatcgaagag tgtgccgccc ggcggcaggc gaggatcgac     1440

agcgggtccg aggtgatcgt gggcgtgaac aaatatcagc tcgagaaaga ggacgccgtc     1500

gaggtactgg caatcgacaa caccagcgtg cggaaccgtc agatcgaaaa gctcaaaaag     1560

attaagagct ccagggacca agccctggcc gaacggtgcc tggccgcgct gaccgaatgc     1620

gctgccagcg gtgatggcaa cattctcgcc ctggctgtcg atgcaagcag ggcccgatgc     1680

acagtgggcg agatcaccga cgcgttgaag aaggtttttg gagaacataa agccaacgat     1740

aggatggtgt caggagctta caggcaggag tttggcgagt caaaagagat caccagcgcc     1800

atcaagcgcg tgcacaagtt catggagcgg gagggccggc ggcctcggct cctggtagca     1860

aaaatgggcc aggacggtca cgataggggc gccaaagtga tcgccaccgg ttttgccgat     1920

ctgggtttcg atgtcgatat tggcccgctg ttccaaaccc cccgggaggt ggcccagcag     1980

gccgtcgatg cggacgtgca cgcggtggga gtgtccacgc tggcggcagg ccacaagacc     2040

ctggtgcccg agctgatcaa agagctgaac agcctgggtc gcccggatat cctggtgatg     2100

tgcggggggg taatcccccc tcaggattac gagttcctgt ttgaagtggg ggtgtcaaac     2160

gttttcgggc ccggcacccg gatccccaag gcggccgtcc aggtgctcga tgatattgag     2220

aagtgtctgg agaagaagca gcagtcagta                                      2250


<210>  156
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  156
atgctgcggg ccaagaacca gctctttctc ctgtcccctc attacctgag gcaggtgaag       60

gagagcagcg gcagccgcct catccagcaa aggctgctcc accagcagca gccactgcac      120

cccgagtggg ccgcactggc caagaagcag ctcaagggca agaatcccga ggacctgatc      180

tggcacacgc cagaaggaat ctccatcaag cccctgtatt cgaaaaggga cacgatggac      240

ctcccagaag agctgcccgg cgtgaagccc tttacccgag gtccctaccc caccatgtac      300

accttccggc cctggaccat ccggcagtat gccgggttct ccaccgtgga ggagagcaat      360

aaattttaca aggataacat aaaggcaggg caacagggct taagcgtggc ctttgacctg      420

gcgacccaca ggggctacga ttcagacaac ccgcgtgtta ggggggacgt gggcatggcc      480

ggggtcgcca tcgacaccgt ggaggacacc aaaatcctct tcgacggtat acccctggag      540

aaaatgtccg tgtccatgac catgaacggg gcggtgatcc ccgtgctggc gaatttcatc      600

gtcaccggag aggagcaagg ggtgccgaag gagaagctga ccggcacgat acaaaacgat      660

attctgaaag agttcatggt ccggaacacc tacatttttc ccccggagcc ctccatgaag      720

atcattgcgg atatattcga gtataccgcc aaacacatgc ccaagttcaa cagcatcagc      780

atcagcggtt accacatgca agaggccgga gccgacgcta tcctggagct tgcctacacc      840

ctggccgacg gcctggagta cagccgtaca ggcctgcagg cgggcctcac catagatgag      900

ttcgccccca ggctatcctt tttctggggg atcggaatga acttctatat ggagatcgcc      960

aagatgcggg ccggccggcg gctgtgggcc catctgatag agaaaatgtt ccagcccaag     1020

aattcgaaaa gcctgcttct gcgggcacac tgccagacca gcgggtggag cctgacagag     1080

caggacccgt acaacaacat agtccgcact gccatcgagg ccatggccgc cgtcttcggt     1140

gggacgcaga gcctgcacac aaactcattc gacgaggctc tgggtctgcc caccgtgaaa     1200

agcgcccgca tcgcacgcaa tacgcagatc atcatccagg aggaatccgg catccctaag     1260

gtggcggacc cctggggcgg tagctacatg atggaatgcc tgaccaacga cgtctacgac     1320

gcggcgctca agctgataaa cgagattgag gaaatggggg ggatggcgaa ggcggtggct     1380

gagggaatac ccaaactgcg cattgaggag tgcgccgccc gaaggcaggc gcggatcgat     1440

agtgggtccg aggtcatcgt gggcgtaaac aagtaccagc tcgagaagga agacgccgtg     1500

gaggtgctgg ccatcgacaa tacgtcggtg cgcaatcgcc aaatagagaa gctgaaaaag     1560

atcaagagca gccgagacca ggccctggcc gagcgctgtc tggcggccct caccgaatgt     1620

gccgcctcgg gcgatggaaa tatcctcgcg ctcgccgtgg atgcctcccg ggccaggtgc     1680

actgtgggcg aaatcacgga cgccctcaaa aaggtgtttg gcgagcacaa ggccaatgat     1740

cggatggtgt ccggcgcgta ccgccaggag ttcggggaaa gtaaggagat tacctccgcg     1800

atcaaaaggg tgcacaaatt catggagcgg gagggccggc ggccccgcct tttagttgcc     1860

aaaatggggc aggacgggca cgaccggggc gctaaggtga tcgccaccgg cttcgccgac     1920

ctgggcttcg atgtggacat agggcccctc ttccaaaccc cgagggaggt ggcgcagcag     1980

gcggtggacg ccgatgtcca cgcggtcggc gtcagcaccc tggcggcggg gcataagaca     2040

ctcgtgccag agctcatcaa ggaactgaat agcctgggga ggcctgatat tctcgtaatg     2100

tgcggtggtg tgatcccccc gcaggactac gaattccttt tcgaagtcgg ggtgagcaac     2160

gtgttcgggc ccggcaccag aatcccaaag gcggcggtcc aagtgctcga cgatatcgaa     2220

aagtgcctag aaaagaagca gcaatcggtt                                      2250


<210>  157
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  157
atgctgcgcg cgaagaacca gctgtttctc ctgagcccac actacctgcg tcaggtgaag       60

gagagctccg gctcacggct gatccaacag aggctgctgc accagcagca gccccttcac      120

cccgagtggg ccgcactagc caagaagcaa ctcaagggta aaaacccgga ggacctcatc      180

tggcataccc ccgaggggat cagcatcaag cccctgtact cgaagcggga tactatggac      240

ctgcccgaag agctccctgg agtgaaaccc tttactcgag ggccttatcc tactatgtac      300

acctttcgcc cgtggactat caggcagtac gccggcttca gcaccgtgga agagtccaat      360

aagttttaca aggacaatat aaaggccggg cagcagggtc tcagcgtcgc cttcgactta      420

gccacccacc gcggctacga tagcgacaac cctcgggtac ggggagacgt gggaatggcc      480

ggcgtagcca tcgataccgt ggaggacaca aagatcctct tcgacggaat accgctcgaa      540

aagatgtcag tgtctatgac catgaacggg gcggtcatcc cagtactggc aaatttcatc      600

gtgacgggag aggagcaggg cgtgcccaaa gaaaagctga ccggcacgat acaaaacgac      660

atcctgaagg agtttatggt gcgcaacacc tacatcttcc cgcccgagcc ctcgatgaag      720

atcatcgcgg acatcttcga gtacaccgcc aagcacatgc ccaagtttaa cagcatcagc      780

atatccgggt accatatgca ggaggccggc gccgacgcca tcctcgaact ggcctatacc      840

ctcgccgacg gactggagta cagccggacc ggactgcagg ccgggctgac aatagacgag      900

tttgcacccc ggctctcctt cttctggggg atcgggatga acttttatat ggagatcgcc      960

aaaatgcgtg ccggtcggcg cctgtgggcg catctcatcg aaaaaatgtt tcagccaaag     1020

aacagcaaaa gcctgctgct gcgagcccac tgtcaaacca gcgggtggag cctgacggag     1080

caggaccctt ataacaacat tgtgcgaacc gccatcgaag ccatggccgc ggtgttcggg     1140

ggcacccagt ccctgcacac caactccttc gacgaggccc tcggactccc caccgtcaag     1200

tccgcgcgca tagcgcggaa tacccaaatc atcatccagg aggagagcgg tatcccgaaa     1260

gtggccgacc cttggggcgg aagctacatg atggagtgcc tgactaacga cgtgtacgat     1320

gccgccctga agctgataaa cgaaatcgag gagatgggtg gcatggcgaa ggccgtcgcg     1380

gaagggatcc ccaagctgcg gatcgaagaa tgcgcagcca ggcgccaggc ccggatcgac     1440

tccgggtccg aggtgatcgt gggcgtgaac aagtatcagc tggagaagga agatgccgtg     1500

gaggtgctgg ccatcgacaa cacctccgtg cggaacagac aaattgaaaa actcaaaaaa     1560

atcaagagca gccgcgacca ggccctcgcc gaaaggtgcc tggcggcgct gactgaatgc     1620

gccgcgtcgg gagacgggaa catactggcc ctggctgtcg acgcctccag ggcccggtgt     1680

accgtcggcg aaataacgga tgcgctaaag aaggtcttcg gggagcataa agcgaacgac     1740

cggatggtga gcggcgcata ccgacaggag ttcggagaga gcaaggagat cacatcagcc     1800

atcaagcgcg tccataagtt tatggaacgc gaaggccggc ggccccgact gctggtcgcg     1860

aagatggggc aggacggcca cgacagaggg gccaaggtca tagccacggg ctttgcggac     1920

ctggggtttg acgtggacat agggccctta ttccagaccc cgcgggaggt ggcccagcag     1980

gccgtggatg cggacgtaca tgctgtcggg gtgtcaacgc tggcagccgg gcacaagacc     2040

ctggtgcccg agctcattaa agagctgaac agtctgggta ggccggacat cctcgtcatg     2100

tgcggcggag tgatcccgcc ccaggactac gagttcctct tcgaggtggg tgtctcaaac     2160

gtctttggcc ccggcacccg catccccaag gccgccgtac aggtccttga cgacattgag     2220

aagtgtctcg agaaaaagca gcagtccgtt                                      2250


<210>  158
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  158
atgctgcgcg ctaaaaacca gctctttctc ctgtcaccgc actacctgag acaggtgaaa       60

gagtcgagtg gctcaagact gatccaacaa aggctgctgc accagcagca gcccctgcac      120

cccgagtggg cggccctcgc caagaaacaa cttaagggca agaaccccga ggacctcatc      180

tggcatactc ccgaggggat ctcgataaag cccctctatt caaagaggga taccatggac      240

ctgccagagg agcttcctgg cgtgaaacca ttcacgcggg gcccataccc taccatgtac      300

acattccggc cgtggactat ccgccaatat gccggattca gtaccgtcga ggagagcaat      360

aaattctaca aagacaacat caaggcgggg cagcaggggc tgtccgtggc cttcgatctg      420

gctacccacc gcgggtacga ttccgataac ccccgtgttc gcggggatgt cgggatggct      480

ggcgtagcta tcgacaccgt ggaggatacc aagatcctgt tcgacggtat ccccctagaa      540

aagatgtccg tgagcatgac catgaatggc gccgtcatcc ctgtactggc caatttcatc      600

gtcaccgggg aggagcaggg ggtgcccaag gagaagctca cgggcaccat acagaacgac      660

attctgaagg agtttatggt gcgaaacacc tacatattcc cccccgaacc gtccatgaaa      720

atcatcgctg atatctttga gtacacggcc aagcacatgc ctaagttcaa cagcatctcc      780

atatccggct accatatgca ggaggccgga gctgacgcca tactggaact ggcctataca      840

ctggccgacg gactggagta tagccggacc ggcctgcaag ccgggctcac catcgacgag      900

ttcgcaccgc gactaagctt cttctggggc atcggcatga acttctacat ggagatagcc      960

aagatgcgcg caggtcgcag gctctgggcc catcttatcg aaaagatgtt ccaacccaag     1020

aactccaaaa gcctcctgct ccgcgcgcac tgtcagacca gcggctggtc actgacggag     1080

caggatccat acaacaacat cgtgcgcacg gccatcgagg ccatggcagc tgtattcggg     1140

ggcacccagt ccctgcacac caactccttt gacgaggccc tgggcctccc caccgtcaag     1200

agcgcgcgta ttgcgcgcaa cacccagatc atcatccaag aagagtccgg tattcctaag     1260

gtggccgacc cctggggcgg ctcgtacatg atggagtgcc tgaccaacga cgtgtacgac     1320

gccgccctga agctgatcaa tgagatcgag gagatgggtg ggatggccaa ggctgtcgcc     1380

gaaggcatcc cgaagctgcg catagaagag tgcgcagccc gacggcaggc acggatcgac     1440

tccgggtccg aggtgatagt gggcgttaat aagtaccagc tggagaagga ggacgctgtt     1500

gaagtcctgg ccatcgacaa cacctctgtg cgtaacaggc agatcgaaaa gctcaagaag     1560

atcaagtcca gccgcgacca ggccctggcc gagcggtgcc tggctgccct gaccgagtgt     1620

gccgcgtcag gggatggcaa catcctcgcc ctggccgtcg acgcctcccg cgccaggtgt     1680

accgtcgggg aaatcaccga cgccctgaag aaggtatttg gcgagcacaa agccaacgat     1740

aggatggtaa gcggcgccta caggcaggag ttcggggaat ccaaagagat cacctccgcc     1800

atcaagcggg tccacaagtt catggaaaga gagggccgta gacctcgact gctggtggcc     1860

aagatgggcc aggatggtca tgatcggggc gccaaagtga tcgcgaccgg gttcgccgat     1920

ctgggattcg acgtggacat cggccccctc ttccagacgc ccagggaggt agcgcagcaa     1980

gccgtggatg ccgacgtgca cgcggtgggc gtgtccaccc tcgcggccgg tcacaagacc     2040

ctcgtgcccg aactcatcaa ggagctgaac agcctggggc ggcccgacat cctggtcatg     2100

tgtggaggcg tcattccacc ccaggactat gagtttctct tcgaggtcgg cgtgtcaaac     2160

gtgtttggcc ccggcactag gatacccaaa gcggcagtcc aggtcctcga cgatatcgag     2220

aagtgtctcg agaagaagca acagtccgtg                                      2250


<210>  159
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  159
atgctccgtg ccaagaacca gctgttcctg ctgagccccc actatctccg acaggtgaaa       60

gagtcgtccg gaagcaggct gatccagcaa agactgctgc accaacagca accactgcat      120

cccgagtggg ccgcgctggc caagaagcag ctgaagggca agaaccccga agatctcatc      180

tggcacacac ccgagggcat cagcatcaag cccctgtatt ccaagaggga taccatggac      240

ctgccagaag agctgcccgg cgtcaagcct ttcacacgag gcccctaccc gaccatgtac      300

accttcaggc cctggacgat ccgacaatat gccggcttca gcaccgtgga ggagagcaac      360

aaattttaca aggacaacat caaggccggg caacaaggcc tatccgtcgc cttcgacctg      420

gcgacccacc gggggtacga cagcgataac ccccgcgtgc gtggagacgt gggaatggcg      480

ggggtagcta ttgacacggt agaggataca aagatcctgt ttgatgggat cccgctggaa      540

aagatgagcg tgtccatgac gatgaacggg gccgtgattc ccgtcctggc caatttcatc      600

gtcacgggtg aagaacaagg cgtacccaaa gaaaagctga ccggtaccat ccaaaacgat      660

atcctgaaag agttcatggt gaggaatacc tacatctttc cccctgaacc cagcatgaag      720

atcatcgccg acatcttcga gtataccgcc aaacacatgc ccaagttcaa tagtatcagc      780

atctcaggct atcacatgca ggaagccggg gccgacgcga tactggagct ggcctatacc      840

ctggccgatg gcttggaata tagccggacg gggctccagg ccggcctcac catcgacgaa      900

ttcgccccca ggctgagctt cttctggggg atcgggatga acttctacat ggagatcgcc      960

aagatgcggg cggggcggag gttgtgggcc catctcatag agaaaatgtt tcagcccaag     1020

aactcgaagt ccctcctgct ccgggcacat tgccagacca gcgggtggtc tctcaccgag     1080

caggatccct ataataacat cgtgcgcacc gccatcgagg ccatggccgc cgtcttcggt     1140

ggcacccaga gcctccacac aaactccttc gacgaagccc ttggcctgcc caccgtgaag     1200

agcgcacgga tcgcccggaa cacccagatc atcatccagg aagagtcagg gatccccaag     1260

gtggcggatc cctggggcgg cagctatatg atggagtgtc tgaccaacga cgtttatgat     1320

gccgccctca agctcatcaa tgagattgag gagatggggg gtatggccaa ggcagtggcg     1380

gagggaatac ctaagctccg cattgaagag tgtgccgccc ggcggcaagc ccggatagac     1440

tccggcagcg aggtgatcgt gggcgtgaac aagtatcaac tggagaagga ggacgccgtg     1500

gaggtcctgg ccattgataa cacctccgtg aggaacagac agatcgagaa gctcaagaag     1560

atcaagtcaa gccgtgacca ggccctcgcc gaacgctgtc tggctgccct caccgaatgc     1620

gccgccagcg gcgacgggaa catcctggcc ctggcagtgg acgccagcag agccaggtgc     1680

accgtgggcg aaataaccga cgccctgaag aaggtgttcg gcgagcacaa agctaacgat     1740

cggatggtct cgggggccta ccgccaggaa ttcggggagt ccaaggagat cacgagtgcc     1800

atcaaaagag tccataaatt catggagcgc gaggggaggc gacccaggct gttggtcgct     1860

aaaatggggc aggacggcca cgacaggggc gccaaagtca ttgcgaccgg gtttgccgac     1920

ctgggcttcg acgtggacat cgggccgctg ttccaaaccc cccgtgaggt cgcccagcag     1980

gcggtggacg ccgatgtgca cgccgtgggg gtgagcacac tcgccgccgg tcataagacg     2040

ttggtgccag agctgataaa ggagctgaac tccctcgggc ggccagatat actggtgatg     2100

tgtgggggcg tgataccccc acaggactac gagttcctgt tcgaagtggg ggtaagcaac     2160

gtgttcggcc cagggaccag gataccgaag gcggcggtcc aggtgctgga cgacattgaa     2220

aaatgtttgg aaaagaagca acagtccgtc                                      2250


<210>  160
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  160
atgctgcggg ccaagaatca gctgtttctg ctgagccccc actacctgcg tcaagttaag       60

gaaagttcag gatccaggct gatccagcag aggctgctgc accagcagca gccgctgcat      120

ccggagtggg ccgcgcttgc caaaaagcaa ctgaagggga agaatcccga ggacctgatc      180

tggcataccc ctgaggggat ctcaattaag ccactgtact ccaagcggga taccatggac      240

ctccccgagg agctgcccgg ggtcaaaccc ttcacccggg gtccctaccc caccatgtac      300

actttccgac cctggaccat cagacaatac gccggcttct ccaccgtgga ggagagcaac      360

aagttctata aagacaatat caaggcagga cagcagggcc tctccgtggc ctttgacctc      420

gccacgcaca ggggttatga tagcgacaac ccccgcgtgc gaggcgatgt tgggatggcc      480

ggcgtggcga ttgacaccgt ggaagacacg aagatactct ttgacggcat ccccctcgag      540

aagatgtccg taagcatgac aatgaacggc gcggtcatcc ccgtgctggc caacttcatt      600

gttactggcg aggagcaggg ggtcccgaaa gagaaactga ccgggaccat acagaacgac      660

atactcaaag agtttatggt ccgcaataca tatatcttcc cccccgagcc ctcaatgaag      720

atcatagcgg acatctttga atacacggcc aagcacatgc caaagttcaa tagcatcagc      780

atctccggct atcacatgca ggaggcgggt gccgacgcca tcctggaact cgcctatacc      840

ctggcggacg gcctggagta cagccgcacg gggctccagg cgggtctgac catcgacgaa      900

ttcgcccccc ggctgtcctt cttttggggg atcggtatga atttttacat ggagatcgcc      960

aaaatgcgcg ccgggcgcag gctgtgggcc catctgatcg aaaagatgtt tcagcccaag     1020

aacagcaagt cgctgctgct gcgggctcat tgccagacat cgggatggtc cctcactgag     1080

caagatccct acaacaacat tgtgcgcaca gcgatcgagg caatggccgc agtgttcggg     1140

ggtacccagt ccctccacac aaactccttc gacgaggccc tggggctacc gacggtcaaa     1200

agcgcccgaa tcgcgcgcaa cacccagatc ataatccagg aggaaagcgg tatccccaag     1260

gtggcagatc cgtggggcgg tagctatatg atggagtgcc tgaccaacga cgtctatgac     1320

gctgcactga agctcatcaa cgaaatcgaa gagatgggtg gcatggccaa agccgtagcc     1380

gagggaatcc caaagcttcg aatcgaggag tgcgctgcca ggagacaggc ccgcatcgat     1440

tcaggtagcg aggtgatcgt tggggtgaat aagtaccagc tcgagaagga ggacgccgtg     1500

gaagtgctgg ccatagacaa cactagcgta cgcaacaggc agattgagaa gctgaagaaa     1560

atcaagtcga gccgagacca ggccctcgcc gaaaggtgcc tggccgcatt gaccgaatgc     1620

gccgccagcg gcgacgggaa catcctcgcc ctggctgtgg acgccagcag ggccaggtgc     1680

acggtggggg agatcacgga tgctctcaaa aaggtgtttg gtgagcacaa ggctaatgac     1740

cggatggtgt cgggcgccta tcggcaagag ttcggcgaaa gcaaagagat caccagcgcc     1800

atcaagcgag tgcacaagtt catggaacgc gagggcagga ggcccaggct gctggtggcc     1860

aagatggggc aggacggcca cgaccgaggt gccaaagtga tcgccactgg gttcgcggac     1920

ctgggcttcg atgtggacat tggccccctc tttcagaccc cccgagaggt ggcccagcag     1980

gccgtcgacg ccgatgtgca tgcggtcggc gtgagcaccc tcgctgccgg tcataaaacc     2040

ctcgtgcctg agctgatcaa ggaactgaac tcactggggc ggcccgacat cctggtcatg     2100

tgtggaggag tgatcccgcc gcaggactac gagttcctat ttgaggtagg cgtgagcaac     2160

gtctttgggc cgggaaccag gatcccaaag gctgcagtgc aggtgctcga cgatatagaa     2220

aagtgcctcg aaaaaaaaca gcagtccgtg                                      2250


<210>  161
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  161
atgctgagag cgaaaaacca gctctttctg ctgagccccc actatctgcg gcaagtcaag       60

gagtcctccg gctccaggct gatacagcag cgcttactcc atcagcagca gcccctgcac      120

ccggagtggg ccgcgctggc taaaaaacag ctgaagggga agaaccccga ggacctcata      180

tggcacaccc cggagggtat cagcatcaag ccgctgtact ccaagcggga tacgatggat      240

ctccccgagg agctgccagg tgtgaaacct ttcacacggg ggccgtatcc caccatgtac      300

acctttcggc cttggacaat ccggcaatac gccgggtttt caactgtcga ggagtctaac      360

aagttttaca aggacaacat caaggcaggc caacagggcc tcagcgtcgc cttcgatctg      420

gccacccaca gggggtacga ttccgacaac cccagggtgc gcggggacgt gggcatggcc      480

ggcgtggcca tcgacaccgt cgaagatacg aagatcctgt tcgacgggat cccgctcgaa      540

aagatgagcg tgtcgatgac catgaacggg gccgtgatcc cagtgctcgc caatttcatt      600

gttaccgggg aagagcaggg cgtgccaaaa gaaaaactca cgggaactat ccaaaacgac      660

atcctgaaag agttcatggt aaggaacacc tatatcttcc cccccgagcc cagcatgaag      720

atcatcgcgg atatctttga gtataccgcc aagcatatgc ccaagttcaa ttcgatcagc      780

atcagcgggt accacatgca ggaggcaggc gccgacgcca tcctggagct ggcgtacacg      840

ctggccgatg gactggagta ctcccggacc gggctgcagg ccggcctcac catcgacgag      900

ttcgccccac ggctatcctt tttttggggg atcggtatga atttctatat ggagatcgcc      960

aagatgcgcg ccggtcggag gctctgggcc cacctgatcg agaagatgtt ccagccgaaa     1020

aactccaaat ccctgctgct ccgggcccac tgccagacgt ccggttggtc cctgactgag     1080

caagatccgt ataataacat cgtgcgcacc gccatcgagg cgatggccgc cgtcttcggg     1140

ggtacccagt ccctccacac caattccttc gacgaagccc tgggcctccc caccgtgaag     1200

tccgcacgta tcgcacggaa cacccagata atcatccagg aggagagcgg gatccccaag     1260

gtagccgatc cttggggcgg atcctacatg atggagtgcc tgaccaacga cgtctacgac     1320

gcggccctga agctgatcaa cgaaatcgag gagatgggcg gcatggcaaa ggccgtcgcc     1380

gaggggatcc ccaagctgcg aatcgaagaa tgcgccgcaa gaaggcaggc tcggatcgat     1440

tccgggagcg aagtgatcgt aggggtgaat aaatatcagc tggaaaagga ggatgccgtc     1500

gaggtcctgg ccatcgataa cacctccgtc cggaatcgtc agatcgaaaa actgaagaag     1560

atcaagtcga gccgcgacca agccctggca gagcgttgcc tcgccgcact gaccgaatgt     1620

gcggccagcg gcgacgggaa catcctggcc ttagccgtgg acgcctcccg tgcccggtgc     1680

acggtgggcg agatcacgga cgccctcaaa aaggtcttcg gagagcacaa agccaatgac     1740

aggatggtgt cgggggccta caggcaagag ttcggcgaat ccaaggagat cacaagtgcc     1800

atcaagcgcg tacataaatt catggagcgc gaaggtcgtc gcccccggct gctggttgcc     1860

aagatgggac aggacggcca cgatagaggg gcgaaagtca ttgccaccgg attcgccgac     1920

ctggggtttg acgtggacat cggtcctctg tttcagaccc cccgcgaagt ggcccagcag     1980

gccgtcgatg ccgatgtgca cgcggtgggg gtgagcactc tggccgccgg ccacaagacc     2040

ctggtacccg agctcatcaa ggagctgaac tccttggggc ggcccgacat cctggtgatg     2100

tgcgggggag tcatcccgcc tcaggactac gagttcctct tcgaggtggg cgtcagtaac     2160

gtgttcgggc ctggtactcg cattcccaag gcggcggtcc aggtactgga cgatatcgaa     2220

aagtgcctcg aaaagaagca gcagtcggtg                                      2250


<210>  162
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  162
atgctgagag ccaaaaacca actgtttctc ctcagcccac actatttgcg gcaggtgaaa       60

gagtcgtcgg gttctcgcct cattcagcaa cgtctgctgc accagcagca gccgctgcac      120

cccgagtggg ccgccctggc gaagaagcag ctgaagggca agaaccccga ggacctgatc      180

tggcacaccc cggaaggtat cagcataaag ccgctctact ccaagcggga taccatggac      240

ctgcccgagg aacttcccgg cgtgaagccc tttacccgcg gtccctaccc gacgatgtat      300

accttccgtc catggactat acgtcaatat gcgggcttca gcaccgtgga ggagagtaac      360

aagttttaca aggacaatat caaggcgggc cagcaaggcc tgtcagtggc ctttgacctc      420

gccacccaca gggggtacga cagcgacaat cctcgagtgc gtggcgacgt cggcatggcg      480

ggtgtcgcca tcgacaccgt ggaggataca aagatccttt tcgacgggat ccccctcgaa      540

aagatgtccg tgagcatgac catgaacggg gcagttatac ccgtgctggc taacttcatc      600

gtgacaggag aggaacaagg ggtacccaag gaaaagctga ccgggaccat ccagaatgac      660

atcctgaagg agttcatggt gaggaacacc tatattttcc cacccgagcc ctccatgaag      720

atcatagccg acatatttga gtataccgcc aagcacatgc ccaagtttaa cagtatatcc      780

atcagcgggt atcacatgca agaggccgga gcggacgcca ttctcgagct cgcctacacg      840

ctggcggacg gcctggaata ctcccgtacg gggctgcaag cggggctgac catcgatgag      900

ttcgcccccc gcctgtcctt cttttgggga atcggtatga acttctacat ggagatcgcc      960

aagatgcgcg ccgggagacg gctgtgggcc cacctcatcg agaagatgtt ccaacccaag     1020

aacagcaagt ccctgctgct ccgggctcac tgtcagactt ccggctggtc cttgactgaa     1080

caggacccgt acaacaacat cgtgagaacg gccatagagg ccatggccgc cgtgtttggc     1140

ggaacccaat cgctccacac caactctttc gacgaggccc tgggcctccc aacggtcaaa     1200

tccgcccgca tcgccaggaa cacccaaatc atcatccaag aagagagcgg catccccaag     1260

gtggccgatc cctggggcgg cagctatatg atggagtgtc ttaccaacga tgtgtacgat     1320

gccgccctga agttgatcaa tgaaatcgaa gagatgggcg ggatggccaa agccgtggcc     1380

gaggggatcc ccaagctgcg gatagaggag tgcgcggcaa ggcggcaggc ccggatagac     1440

agcgggagcg aagtgatcgt gggcgtgaac aaataccagc tggaaaagga agacgcagta     1500

gaggtcctcg caattgacaa caccagcgtg agaaaccgcc agatagagaa gctcaaaaag     1560

atcaagtcct cacgggacca ggccctcgcc gagcggtgcc tggccgctct gaccgagtgt     1620

gccgcgtccg gtgatggcaa catccttgcc ctcgcagtgg atgcctcccg ggcaagatgt     1680

acagtggggg agataacgga cgccctgaag aaagtgtttg gggaacataa agccaacgac     1740

cgcatggtca gcggggccta taggcaagag ttcggggaat ccaaggagat cacctccgcc     1800

attaaacggg tgcacaagtt tatggagagg gagggccgga ggccccgact cctggtggcc     1860

aagatggggc aagacggaca cgacaggggc gctaaggtca tagccaccgg gttcgccgac     1920

ctggggttcg atgtagacat tggccccctg tttcagaccc cccgcgaggt ggcgcagcag     1980

gccgtggacg ccgacgtcca tgccgtgggt gtcagcaccc tcgcggccgg gcataagaca     2040

ctggtgcccg agctgatcaa ggagctaaat agcctcggga gaccggatat tctcgtgatg     2100

tgcggagggg tcataccgcc ccaggactac gagttcctct ttgaggtggg cgtgtcaaac     2160

gtcttcggcc ccgggacccg gatccccaag gccgccgtgc aggtgctgga cgacatcgaa     2220

aagtgcctgg agaaaaagca gcagagtgtc                                      2250


<210>  163
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  163
atgctgcgag cgaagaacca gctctttctg ctgagccccc attacctaag gcaggtgaag       60

gaaagctccg gcagccgcct gatccagcag cggcttctgc accaacaaca gccactccac      120

ccggagtggg ccgccctggc caagaagcaa ctgaagggga agaaccccga ggacctaatc      180

tggcataccc cggaaggcat ctccatcaag cctctgtact ccaagagaga caccatggac      240

ctgcccgaag agctccccgg cgtgaagccc tttaccaggg gcccctatcc caccatgtac      300

accttccgtc cgtggacaat ccgccagtat gccggtttca gcaccgtcga ggagtccaac      360

aaattctaca aggacaacat caaggccggg caacaggggc tcagcgtggc cttcgatctg      420

gccacccacc ggggctatga cagcgacaac ccgcgagtgc ggggagatgt cggcatggcc      480

ggcgtggcta tcgacaccgt cgaggacacc aagatcttgt ttgacgggat cccgctggag      540

aaaatgagcg tctcaatgac gatgaatgga gccgtgatcc ccgtgctggc caacttcatc      600

gtcaccggtg aggagcaggg cgtgcccaaa gagaagctaa ccggcaccat ccagaacgat      660

atactcaagg agttcatggt gcggaacaca tatatcttcc cccccgagcc ctccatgaag      720

ataatcgcgg acatttttga gtacacggcg aagcacatgc ccaagttcaa tagcataagc      780

atctccggct accacatgca ggaggccgga gccgatgcca tcctcgaact tgcgtatacc      840

cttgccgacg gcctggagta ctcccgtacc ggcctccagg ccgggctgac catcgatgaa      900

ttcgcgcctc gtctgtcctt cttctggggt atcggcatga acttctatat ggagatcgcc      960

aagatgaggg ccggccggcg gctgtgggcc cacctgatcg agaagatgtt ccaacccaag     1020

aactccaagt ccctgctgct gcgggcccac tgccagacca gcggctggag cctgacagag     1080

caggacccgt acaacaacat cgtcaggacg gccattgagg ccatggccgc cgtgttcgga     1140

ggcacgcaga gcctgcatac caactcgttc gacgaagccc tgggcctgcc aaccgttaaa     1200

tccgcccgaa ttgcccgtaa tacccagatc attatccagg aagagagcgg catccctaaa     1260

gtggcggacc cctggggcgg gagctacatg atggaatgcc tcaccaacga cgtctatgac     1320

gccgccctga agctcatcaa tgagatagag gaaatggggg ggatggccaa ggccgtcgca     1380

gaaggtatcc ccaagctccg gatagaggag tgcgcggcca ggcgccaagc ccgtattgat     1440

tccggttccg aagttattgt cggagtgaat aaataccagc tggagaaaga ggacgccgtg     1500

gaggtgctgg ccatcgataa tacctcggtc cgcaataggc agatcgagaa gctgaagaag     1560

atcaagagct cccgggacca ggccctggct gagcggtgcc tcgccgccct gacggagtgc     1620

gccgccagcg gtgacggcaa catcctggct ctggccgtgg atgcctcccg cgcccgatgc     1680

acggtggggg agatcaccga cgcactgaag aaggttttcg gcgagcacaa ggccaatgac     1740

cgcatggtga gcggggccta ccgacaggag ttcggcgaat caaaagagat cacgagcgcg     1800

atcaagcggg tccacaagtt catggagcga gaagggagga ggccgcggct ccttgtggcg     1860

aagatgggcc aggatgggca tgatcgggga gccaaggtga tcgccaccgg gttcgccgac     1920

ctcggcttcg atgtcgatat cgggcctcta tttcagaccc caagagaggt ggcccagcag     1980

gccgtcgatg cggatgtgca tgccgtgggt gtgagcactt tggccgccgg ccataagacg     2040

ctggtgcccg agctgatcaa ggagctgaat tccctcggca ggccagatat cctggtgatg     2100

tgcggcgggg tgatccctcc acaggactac gagttcctgt ttgaggtggg cgtgtctaat     2160

gtcttcgggc cgggcaccag gataccaaag gccgcagtac aggttctcga cgatatcgag     2220

aagtgccttg agaagaaaca acagtccgtc                                      2250


<210>  164
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  164
atgctacgcg ccaaaaacca gctgttcctc ctcagtccgc attacctcag gcaggtcaaa       60

gagtccagcg gatcccggct catccagcag cgtctactcc accaacagca gccactgcac      120

ccggagtggg cggccctcgc taaaaagcag ctgaagggta agaacccaga agatctgatc      180

tggcacacgc ctgagggaat ctccattaaa ccgctctact ccaaacgcga caccatggat      240

ctgcccgagg agctgccggg ggtgaaaccc ttcaccaggg ggccctaccc gaccatgtac      300

acctttcggc cgtggaccat aaggcaatac gccggtttct cgaccgtgga ggagagcaac      360

aagttctata aggacaacat taaggcaggg caacaggggc tgagcgtggc cttcgacctg      420

gccacccatc ggggatacga ttccgataat ccccgggtcc ggggcgacgt gggaatggcc      480

ggcgtggcca tcgacacggt ggaggacacc aaaatcctct ttgacggcat cccgctggag      540

aagatgtccg tgtccatgac catgaatggg gccgtaatcc ccgtgctcgc gaacttcata      600

gtcacgggcg aggagcaggg cgtgccgaag gagaaactca caggcactat ccaaaacgac      660

atcctgaagg agttcatggt gcggaacacc tacatcttcc cgcccgagcc gagcatgaag      720

ataattgcgg atatcttcga atacaccgcc aagcatatgc ccaagtttaa ttccatttca      780

atcagcggct atcatatgca ggaggccggg gcggatgcca tcctggagct ggcctatact      840

ctcgccgacg gcctggaata cagcaggacc ggcctgcagg cggggctgac gatcgacgag      900

ttcgctccca ggctgagctt tttttggggg atcgggatga acttttatat ggagatcgcc      960

aaaatgcgag ctggccgccg cctgtgggcc catctcatcg agaagatgtt ccagcccaag     1020

aactccaaga gtctcctgct gcgcgcgcac tgccagacct ccgggtggag cctcaccgaa     1080

caggacccct acaacaacat agtccggacc gcgatcgaag ccatggcggc cgtgtttgga     1140

ggcacgcaaa gtctgcacac caacagcttc gacgaggccc tgggcctgcc aaccgtgaag     1200

agcgcccgca tcgccagaaa tacccagatc attatacagg aggagagcgg aattcccaag     1260

gtcgcggacc cctggggagg ttcctatatg atggagtgcc tgaccaacga tgtgtacgac     1320

gccgctctta agctgattaa cgagatcgag gagatgggcg ggatggccaa agcggtggcc     1380

gagggaatac ccaagctgcg catcgaggaa tgcgccgccc gccgtcaagc acggatcgac     1440

agtggctccg aagtgatcgt gggtgtgaac aagtaccagc tggagaagga ggatgccgtg     1500

gaggtgctgg ccatcgacaa cacctccgtg aggaaccgcc agatagagaa actgaagaag     1560

atcaagagct ccagggacca ggccctcgcc gagcggtgcc tggcagcact gaccgaatgt     1620

gccgcgagcg gggacgggaa catcctggcc ctggccgtgg atgcatcccg ggcccgctgc     1680

accgtcggtg agatcactga tgccctgaag aaggttttcg gggagcacaa ggctaacgac     1740

cgcatggtgt ccggggcgta cagacaggag tttggcgagt caaaggaaat taccagcgcc     1800

atcaagcggg tgcacaaatt catggagcgc gaaggtcgcc gacctaggct gctcgtcgcc     1860

aagatgggtc aggacgggca tgaccgcggc gccaaggtca tcgcgaccgg gtttgccgac     1920

cttgggtttg acgtcgacat cggacccctg tttcagaccc ccagggaagt ggcccagcaa     1980

gccgtcgatg cggacgtgca tgccgtcgga gtgagcaccc tcgcggccgg gcacaagacc     2040

ctggtgcccg agctcatcaa ggaactgaac agccttgggc ggcccgacat cctcgtgatg     2100

tgcggcgggg tgatcccgcc tcaggactac gagttcctat ttgaggtagg ggtgtccaat     2160

gtctttggcc ccgggacaag gatccccaag gccgctgtcc aggtcctgga tgacatcgag     2220

aaatgcctgg aaaagaagca gcagtccgtc                                      2250


<210>  165
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  165
atgctgaggg ctaagaacca gctgttcctg ctctcccccc actacctgag gcaggttaaa       60

gaatcctccg gaagcaggct gatacagcag agactcctgc atcagcagca gcctctacac      120

cccgagtggg ccgccctggc caaaaagcag ttgaaaggca aaaatcccga agatctgatc      180

tggcacaccc ctgaaggcat cagcatcaag ccactgtaca gcaagagaga caccatggac      240

ctgcccgagg agttgccagg cgtgaagcct tttaccagag gcccctaccc cacaatgtat      300

accttccggc cctggacaat tagacagtac gcaggcttca gcaccgtgga ggagtccaat      360

aagttttaca aggacaacat caaggctggg cagcaggggc tctcagtggc cttcgatctg      420

gctacccata gaggctatga tagcgataat cccagagtga gaggcgacgt aggaatggcc      480

ggcgtggcca tagataccgt ggaggatacg aaaatcctct tcgacggcat ccctctggaa      540

aagatgtctg tgagcatgac catgaacggc gcagtgattc ctgttctggc caacttcatc      600

gtcacagggg aagagcaagg cgtgcccaaa gagaagctca cgggcaccat ccagaatgac      660

attctgaaag agttcatggt gagaaacact tacatcttcc cacccgaacc ttcaatgaag      720

atcatcgccg acatcttcga gtatacagcc aaacacatgc ctaagttcaa tagcatcagc      780

atctccggat accatatgca ggaggctggc gctgacgcca ttctggagct ggcctacacc      840

ctggcagacg gtctggagta cagcagaaca ggtcttcagg ccggtctgac cattgacgag      900

tttgccccaa ggctgtcctt cttctgggga atcggcatga acttctacat ggagatcgcc      960

aagatgagag ccggtagaag actgtgggcc cacctgatcg agaagatgtt ccagcctaag     1020

aattccaaga gcctgctgct gcgcgcccac tgccaaacct ctggctggtc attaaccgag     1080

caggatcctt acaataacat cgtgcgaacc gccatcgaag ccatggctgc tgttttcggg     1140

ggaacccagt ccttgcacac aaacagcttc gacgaggccc tgggcctgcc caccgtgaag     1200

agcgccagga ttgcccgaaa cacgcagatc atcatacagg aggagtctgg cattcccaag     1260

gtggccgatc cttggggcgg gtcttatatg atggaatgcc tgacaaatga cgtctacgac     1320

gccgccctga agctcatcaa cgagatcgaa gagatgggcg ggatggccaa agctgtagcc     1380

gagggcatcc ctaagctgag aattgaggaa tgcgccgcta gacggcaggc aaggattgac     1440

agcggcagcg aggtcattgt gggcgtcaac aaataccagc tggagaagga agacgccgtg     1500

gaggtgctgg ccattgacaa cacatctgtg agaaaccggc aaatcgaaaa gctgaaaaaa     1560

atcaagtcct ccagagatca ggctctggct gaaagatgcc tggccgccct gaccgagtgt     1620

gccgcgagcg gcgatggcaa catcctggct ctggccgtgg acgcaagcag agctagatgt     1680

acagtcggcg agattaccga tgcgctgaag aaggtgttcg gcgaacacaa ggccaacgat     1740

cggatggtga gcggcgctta tcgccaggag ttcggagagt ccaaggagat cacctccgca     1800

ataaagaggg tgcacaagtt tatggagcgc gagggaagac ggccccgact gctggtggcc     1860

aagatgggcc aagatggcca tgacagaggg gccaaggtga ttgccaccgg ctttgcagat     1920

ctgggcttcg atgtggacat cggccccctg ttccaaaccc ctagagaggt ggcccagcaa     1980

gccgtcgacg ctgacgttca tgccgtgggc gtctccaccc tggcggcagg acacaagaca     2040

ctggtgcctg agctgatcaa ggaactgaat agcctcggga gacccgatat cctggtgatg     2100

tgcggaggcg tgatcccccc tcaggactac gaatttctgt tcgaggtggg cgtctcgaat     2160

gtgttcggac ccggcacaag aattcccaag gctgctgtcc aggtcctgga cgacattgag     2220

aaatgcctgg agaagaagca gcagtccgtg                                      2250


<210>  166
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  166
atgctgcgcg ccaagaacca gctgttcctg ctgagccccc actacctgag acaagtgaag       60

gagagcagcg gcagcagact gatccagcag aggctgctcc accagcaaca gcccctgcat      120

cccgagtggg ctgctctcgc taagaaacag ctgaagggca agaaccccga ggacctgatc      180

tggcacacac ctgagggcat atcaatcaaa cccctctatt cgaagcgaga caccatggac      240

ctgcccgagg aattacctgg cgtgaaacca ttcaccagag gcccttatcc caccatgtac      300

acttttaggc catggacaat tcggcagtac gcaggctttt ccactgtgga agagagcaat      360

aagttttaca aagataacat taaggccggt cagcagggcc tgagtgtggc atttgacctg      420

gctacccaca gaggctatga cagcgacaac cccagagtga gaggcgacgt gggcatggcc      480

ggcgtcgcta tcgacaccgt tgaagacacg aagattctgt tcgacggcat ccccctggag      540

aagatgagcg tttccatgac catgaacggc gctgtgatcc ccgtgctggc caatttcatc      600

gtgacaggag aggagcaggg cgtgcctaag gagaagttga ctggcaccat ccagaatgac      660

atcctgaagg aattcatggt gcggaacacc tacatcttcc cccctgaacc tagcatgaaa      720

atcatcgctg acatctttga gtacacagcc aagcacatgc cgaagttcaa cagtatcagc      780

atctctggct atcacatgca ggaggcaggc gctgacgcca ttcttgaact cgcctacacc      840

ctggccgacg gcctagagta ctccagaaca gggctgcagg ctggcctgac tatcgacgag      900

tttgcccctc gcctgagctt tttttggggc attggaatga atttctatat ggagatcgcc      960

aagatgcgcg ctggaagaag actctgggcc caccttatcg agaagatgtt tcagccaaaa     1020

aatagcaagt ccctgctgct gagggcccac tgccagacct ctggctggag ccttactgag     1080

caggacccct acaacaacat tgtgcggacc gccattgagg ctatggccgc tgtgttcggc     1140

gggacccaga gcctgcacac caatagtttc gacgaggccc tgggattgcc cacggtgaaa     1200

tccgctcgga tcgcccggaa cacacagatc atcattcagg aggaaagcgg catccctaag     1260

gtggccgacc catggggcgg cagctatatg atggaatgtc tgaccaatga cgtgtacgac     1320

gccgctctga aactaattaa cgagatagag gaaatgggcg gcatggctaa ggccgtggcc     1380

gagggcatcc ctaagttgcg tatcgaagaa tgcgccgccc gtagacaggc caggatcgac     1440

agcggctcag aggtgatcgt tggagtgaac aaatatcagc ttgagaagga ggacgccgtg     1500

gaagttcttg ccattgacaa cactagcgtc cgtaacagac agatcgagaa actgaaaaag     1560

atcaagtcga gtagagacca ggctctggcc gagaggtgcc tggcagctct tactgaatgc     1620

gccgctagcg gagacggaaa cattctggcc ctggccgtcg acgcctcccg ggccaggtgc     1680

accgtgggag aaatcactga cgccctgaag aaggtcttcg gcgaacacaa ggctaacgac     1740

cggatggtgt caggcgcgta cagacaggag tttggcgaat ccaaggagat cacgagcgcc     1800

atcaagagag tgcataaatt catggagcgg gagggtagga ggcccagact gcttgtggcc     1860

aagatgggcc aggacggcca tgatagagga gctaaagtaa tagctacagg cttcgctgat     1920

ctgggcttcg atgtggatat cggccccctg ttccagaccc caagagaggt ggcccagcag     1980

gcagtggatg cagacgtgca tgcggtgggc gtgagcaccc tcgccgccgg tcacaagaca     2040

ctggtgcccg agctgatcaa ggagctgaat agcctgggcc ggcccgatat cctcgtgatg     2100

tgcggaggcg tgattccccc tcaagactac gaattcctgt tcgaggttgg agtgtctaat     2160

gtgtttggcc caggcaccag aatccccaaa gctgccgttc aggtcctcga tgacattgaa     2220

aaatgcttag agaagaagca gcagagcgtg                                      2250


<210>  167
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  167
atgctgaggg ctaagaacca gctgtttctg ctttctcccc actacctccg ccaggttaag       60

gagtcctctg gaagcaggct catccagcaa agactgcttc accagcagca gccactgcac      120

cctgagtggg ccgccctggc taaaaagcag ctgaagggca agaaccccga ggatctgatt      180

tggcacacgc ccgagggcat ctccatcaag cctctgtact ccaagagaga taccatggac      240

ctgcccgagg aactccctgg cgtcaagcca ttcacacggg gcccctaccc cacaatgtac      300

acattccggc cttggacgat taggcagtat gctgggttct ctacagtaga ggagtccaac      360

aaattctata aggacaacat caaggccgga cagcaaggcc tttctgttgc cttcgacctc      420

gctacccacc gcggctatga tagcgataat cccagagtga ggggcgacgt gggcatggcc      480

ggggtggcta ttgacaccgt ggaggatact aagatcctgt ttgacggcat ccctctggag      540

aagatgagcg tgtctatgac catgaacggg gctgtgattc ccgtgctggc taatttcatc      600

gtgaccggag aggagcaggg cgtgccaaag gagaagctga caggaacaat tcagaacgac      660

attcttaagg agtttatggt gagaaacacc tatatattcc cccccgagcc cagtatgaag      720

atcatcgctg acatcttcga gtacacagct aagcacatgc ctaagtttaa cagcatcagt      780

atcagcggct accacatgca ggaggccggc gccgacgcta tcctcgagct ggcttacacc      840

ctggccgatg gcctcgagta ctcgagaacc gggctgcagg cgggactgac catcgatgag      900

ttcgccccca ggctcagttt cttctgggga atcggcatga acttctatat ggagatcgcc      960

aagatgaggg ccggaagaag actttgggcc cacctcattg agaaaatgtt ccagcccaag     1020

aatagcaagt cactgctgct gagggcacac tgccagacca gcggatggag cctgactgaa     1080

caggacccct acaacaacat cgttcggacc gcaatcgaag ccatggccgc agtgttcgga     1140

gggacccagt ctctccatac caactccttc gacgaagccc tcggtctgcc tacagttaaa     1200

agcgccagaa tcgctcggaa cacccagatc atcatccagg aggaaagcgg gatacccaag     1260

gtggctgacc cctggggggg ttcctacatg atggagtgcc tgaccaatga cgtgtacgat     1320

gccgcactca agctgattaa tgagatcgaa gaaatgggag gaatggctaa ggctgtggcc     1380

gaaggaatcc caaagttgag aatcgaggag tgcgctgcca ggaggcaggc ccgcatcgac     1440

agcggaagcg aagttatcgt gggcgttaat aagtatcagc tggagaagga ggacgccgtg     1500

gaggtgctgg ctatcgacaa cacctcagtc agaaaccgcc agatcgaaaa actgaaaaaa     1560

attaagtcga gccgagatca ggcactcgcc gagcgttgcc tggccgccct gactgagtgc     1620

gccgcctcag gagacggcaa catcctggcc ctcgccgttg acgccagtag agcccgatgc     1680

actgtgggag agattactga cgccctcaag aaggtgtttg gagagcacaa agccaacgat     1740

aggatggtga gcggcgctta cagacaggag ttcggcgaat ctaaggaaat cacttctgcc     1800

atcaaaagag ttcataagtt tatggagaga gaggggagaa ggccccgcct gcttgttgcc     1860

aagatgggac aggacggcca tgatagagga gccaaggtga tcgccaccgg cttcgcagac     1920

cttggcttcg acgtcgacat tggacccctg ttccagaccc caagagaggt ggctcaacag     1980

gccgtggacg ccgatgtcca cgccgtgggc gtgtctaccc tggccgccgg ccacaagaca     2040

ctcgtgcccg agctgatcaa ggagctgaac agcctcggac ggcctgatat actggtgatg     2100

tgcggcgggg tgatcccccc tcaggactac gaatttcttt tcgaagtcgg agtgagtaac     2160

gtgttcggcc ccggaacgcg catacctaag gctgctgtgc aggtgctgga tgatattgag     2220

aaatgtcttg agaagaagca gcagagcgtg                                      2250


<210>  168
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  168
atgctgaggg ccaaaaatca gcttttcctg ctcagtccac actatttgag acaggtaaag       60

gaatcttccg gctccagact gatccagcag agactgctgc accagcagca gcctctgcac      120

cccgagtggg ccgctctggc aaaaaaacag ctgaagggca agaaccctga ggacctcata      180

tggcacaccc ccgaggggat ctcaatcaag ccactgtaca gcaagagaga caccatggac      240

ctgccagaag aactgcccgg cgtgaaaccc ttcaccaggg ggccctatcc tacaatgtac      300

actttcaggc cttggaccat aaggcagtat gccggattct ccaccgtgga ggagagcaat      360

aagttctaca aggataacat caaagccggg cagcagggcc tgtccgttgc gttcgacctg      420

gccacccata gagggtacga tagtgacaac cccagggtca gaggcgacgt gggcatggcc      480

ggggtcgcga tagacaccgt ggaggacacc aagatcctgt ttgacggcat ccccctggag      540

aagatgagcg tgtcaatgac catgaacggc gccgtgatcc ccgtcctggc caatttcatc      600

gtgaccgggg aagagcaggg agtgcccaag gaaaagttga cagggaccat tcagaacgat      660

atcctgaagg agttcatggt ccggaatacc tacatcttcc cccccgagcc tagcatgaag      720

atcatcgccg acatcttcga gtacaccgcc aagcatatgc ctaagttcaa ttctatcagc      780

atttccggct accatatgca agaagctgga gcagacgcca tactggagtt ggcctacacc      840

ctggccgatg gcctggagta cagccggacg ggcttacagg ccggactgac catcgacgag      900

tttgcaccca gactgtcctt cttctggggc ataggcatga acttctacat ggagattgcc      960

aagatgcggg ccggcagacg tctctgggct catctcatcg agaaaatgtt ccagcccaag     1020

aacagcaagt ccctcctgct gagggcccac tgccagacca gcggatggag cctgactgaa     1080

caggacccct acaacaacat agtgagaacc gccatcgagg ccatggccgc agtgtttgga     1140

gggacccaga gcctgcatac taactccttc gacgaggccc tgggcctgcc caccgtgaag     1200

tccgctagaa tcgccagaaa tacacagatc ataatccagg aggagtccgg catccctaag     1260

gtggccgacc catggggcgg ctcttacatg atggagtgcc tgaccaacga tgtgtacgac     1320

gctgctctca agctcatcaa cgaaattgag gaaatggggg gaatggctaa ggccgtcgcc     1380

gaagggattc ccaagttacg catcgaggag tgtgccgcca gacggcaggc cagaatcgac     1440

agcggcagcg aggtcatcgt aggtgtgaat aagtatcagc tggaaaaaga ggacgccgtg     1500

gaggtcttgg ccatcgataa cacaagcgtg cggaaccgcc aaatcgagaa acttaaaaag     1560

attaagagca gccgggacca ggccctggcc gagaggtgcc tggcagccct cacagaatgt     1620

gctgctagcg gtgatggcaa tatactggcc ctggctgtcg acgccagtag ggcaaggtgt     1680

accgttgggg agatcaccga cgctctgaag aaggttttcg gcgagcataa ggccaacgat     1740

aggatggtca gcggagctta tcggcaagag ttcggagaga gtaaggagat cacgtccgcc     1800

attaaaagag ttcataagtt catggagcgg gagggcagac ggcctagact gctggtggct     1860

aagatgggtc aggatggcca cgacagggga gcaaaggtga tcgccacagg attcgccgat     1920

ctggggtttg acgtggacat tggccctctc tttcagacgc cgagggaggt ggcccagcag     1980

gcagtagacg ccgacgtgca cgccgtgggc gtgtctacac tggccgccgg tcataagacc     2040

ctggtgcccg agcttatcaa ggagctgaac tcactcggca gacctgacat tctggtaatg     2100

tgtggcggag tgatcccacc ccaggactac gagttcctgt ttgaggtggg cgtgagcaac     2160

gtcttcggcc ccggaactag aatccccaag gccgcagtcc aggtgctgga cgacattgag     2220

aaatgcctgg agaagaagca gcaatccgtg                                      2250


<210>  169
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  169
atgctgcggg ccaaaaacca gctgttcttg ctgtctcccc actaccttcg acaggtcaag       60

gaaagctctg gcagccgtct catccagcag agactgctgc accagcaaca gccactccac      120

cccgagtggg ccgccctggc caagaagcag ctgaagggca agaacccaga ggatctgatc      180

tggcacaccc ccgaaggaat cagcattaaa ccactctaca gcaagagaga caccatggat      240

cttcccgagg aactccccgg cgtgaagcct ttcacccggg gaccttatcc cactatgtac      300

accttccgac cctggaccat tagacagtac gctgggttct ccacagtgga ggagagtaac      360

aaattttata aggataatat caaagccggc cagcagggcc tgtctgtagc cttcgatctg      420

gctacccata gaggatatga tagtgacaac cccagggtca gaggcgacgt gggcatggcc      480

ggcgtggcca ttgacaccgt ggaggatact aagattctgt tcgacggcat tccccttgaa      540

aagatgagcg tgagcatgac gatgaacggg gccgtgatcc ctgtgctggc taacttcatt      600

gtgaccggag aggagcaggg cgtccctaaa gagaaactaa caggaactat tcagaacgac      660

atcctgaaag agtttatggt gcggaatacc tacattttcc cccctgagcc ttctatgaaa      720

atcattgccg acatattcga gtacaccgcc aagcatatgc ccaagttcaa ctctatcagc      780

atttctggct atcacatgca ggaggccggt gccgacgcca tcctggagct ggcatacacc      840

ctggcagatg gcctcgagta tagccggacc ggcctccagg ccggcttgac catcgacgag      900

tttgccccac ggctgtcctt cttctggggc atcggaatga atttctatat ggagatcgcc      960

aaaatgcggg ccggaagaag actgtgggcc cacctgatcg agaagatgtt ccagcccaag     1020

aacagcaaga gcctcctgct gagagcacat tgccagacca gcggatggag cctgaccgag     1080

caggatccct acaataatat cgttaggact gccattgagg ccatggctgc agtgttcggc     1140

ggaacacagt ccctgcatac caacagcttt gacgaagcac tgggcctccc cacagtgaaa     1200

agcgccagga tcgccagaaa cacccagatc atcatccagg aagagagcgg catccccaaa     1260

gttgctgatc catggggcgg ctcatatatg atggaatgtc tgactaacga cgtgtacgat     1320

gctgccctca aactcatcaa cgagattgag gagatggggg gcatggccaa ggccgttgcc     1380

gagggcatcc ccaaacttcg aattgaggag tgcgctgcca gaagacaggc tagaatcgac     1440

agcggctctg aggtgatcgt cggagtcaac aagtaccagc ttgagaagga agatgccgtg     1500

gaagtattgg ccatcgacaa cacatccgtg agaaataggc agatcgagaa actgaaaaaa     1560

atcaagagct ctcgcgacca agcccttgcc gagagatgtc tggccgccct gaccgaatgt     1620

gcagcgagcg gcgatggcaa catcctcgcc ctggccgtgg acgcctctag ggcccggtgc     1680

acagtgggcg agatcaccga cgccctcaag aaggttttcg gcgaacacaa ggcaaacgac     1740

aggatggtta gcggggctta ccgccaggag ttcggggagt ctaaggagat aaccagcgcc     1800

atcaagcgcg tgcacaagtt catggaaaga gaaggtagac ggccaagact cttggtggcc     1860

aaaatgggcc aggacggtca cgaccggggc gctaaagtga tcgccaccgg cttcgccgac     1920

ctgggattcg acgtggacat cggacccctg tttcagacac cccgagaggt ggcacaacag     1980

gccgtggatg ccgatgttca tgccgtggga gtgagcactc tcgccgccgg ccataagaca     2040

ctcgtcccgg aactgattaa ggagttaaat agcctgggcc ggcccgacat cctggtgatg     2100

tgcgggggcg tgatcccccc ccaggactac gagttcctat ttgaggtggg agtcagcaac     2160

gtgttcggcc ccggtacccg gatccccaag gccgcagtgc aggttctgga cgacattgag     2220

aaatgcctgg agaagaagca gcaaagcgtg                                      2250


<210>  170
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  170
atgctcagag ccaagaatca gctatttctt ctgagcccac attatctgag acaggtgaag       60

gagagcagcg gaagcaggtt gatacagcag cggctcctgc atcagcagca gcctctgcat      120

cccgagtggg ccgcactggc aaagaagcag ctgaagggca agaaccctga ggacttgatc      180

tggcacacac ccgagggcat ctctatcaag cctctctata gcaagagaga tacaatggat      240

ctgcccgagg agctgcctgg ggtgaagcct ttcactcggg gcccctaccc caccatgtac      300

accttccgcc cttggaccat taggcagtac gccggcttct ccacagtcga ggagagcaac      360

aagttctata aagataacat caaggcagga cagcaaggcc tgtccgtggc ctttgacctt      420

gccacacaca ggggctatga cagcgataat cctagagtgc gcggcgacgt aggcatggca      480

ggcgtggcaa tagataccgt ggaggacaca aagatcctgt ttgacggcat ccccctggaa      540

aagatgtccg tgagcatgac catgaacggg gcggtgatcc cagtgctggc caactttata      600

gtaaccggcg aagagcaggg cgtgcccaag gagaagctga ctggcacaat ccagaatgac      660

atcctgaagg agttcatggt gaggaacaca tacatctttc cccctgagcc cagcatgaag      720

atcatcgcag atattttcga atacacagca aagcacatgc ccaaattcaa cagcatctcc      780

atctccggct accatatgca ggaggccggc gccgacgcca ttctggagct ggcctacacc      840

ctcgccgacg gtctcgagta ctcacgcaca ggccttcagg ccggcttgac aatcgatgaa      900

ttcgccccca gattgagctt tttctggggc attggcatga atttttatat ggagatagcg      960

aaaatgcggg ctggcagaag actatgggcc catctgatcg aaaaaatgtt ccagcccaag     1020

aacagcaagt cccttctgct gagagcacat tgccagacct ctggatggag cctcaccgag     1080

caggaccctt ataacaatat tgttagaacc gcaattgaag ctatggcagc tgtgttcgga     1140

ggcacccaga gcctgcacac aaactctttt gatgaggcac ttggactgcc cactgtgaag     1200

agtgccagaa tcgctagaaa cacacagata atcatccaag aggagagtgg catccctaag     1260

gttgcggacc cttggggcgg cagctacatg atggagtgcc ttactaacga tgtgtacgat     1320

gcagccctga agctcattaa tgagatcgaa gagatgggcg gcatggcaaa ggcagtggca     1380

gagggcatcc ctaaattgag aatcgaagag tgcgccgcca gaagacaggc ccggatcgac     1440

tcaggcagtg aagtcatcgt gggggtgaac aagtaccaac tcgagaaaga agatgccgtg     1500

gaagtgctgg ccatcgataa cacctccgtt agaaaccgac agatcgaaaa gctgaaaaag     1560

atcaaaagca gcagagatca ggccttagcc gagagatgtt tggccgccct cacggagtgt     1620

gccgccagcg gcgacggcaa catcctggcc cttgccgtgg acgctagtag ggctaggtgc     1680

actgtgggcg agattacaga tgctctgaaa aaagttttcg gagagcacaa ggccaacgat     1740

cgtatggtga gcggagcgta tcggcaggag tttggcgagt ctaaagagat cacctcagct     1800

atcaaacgcg tccataagtt catggagcgg gaaggcagga ggcctcggct gctggtggca     1860

aagatggggc aagatgggca cgatagaggt gccaaggtga tcgccaccgg attcgctgac     1920

cttgggttcg acgtagacat tgggccactg ttccagacac ccagagaggt cgcccaacag     1980

gctgtggatg ccgacgtgca cgcggtgggc gtgagtactc tggccgcggg ccataagacc     2040

ctggtgcccg aactgatcaa ggaactgaat agcctgggca ggcccgatat tctggtgatg     2100

tgcggcgggg tgatcccccc tcaggactat gagttccttt ttgaggtggg cgtgtctaac     2160

gtgttcggcc ccggcacccg gatccctaag gctgccgtgc aagtgctcga cgacatcgag     2220

aaatgcctgg aaaagaagca gcagagcgtg                                      2250


<210>  171
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  171
atgctgagag caaagaacca gctgttctta ctgagccccc actacctgag gcaggtgaaa       60

gagagttcag ggtcacgtct gatccagcag agactgctcc accagcagca gcccctgcat      120

cccgagtggg ccgccctagc taagaagcag ctgaagggca agaaccccga ggacctgatc      180

tggcacactc ccgaagggat tagcatcaag cccctctaca gcaagagaga caccatggac      240

ctgcccgagg agctccccgg agtgaagcca ttcacaaggg gcccctaccc aaccatgtat      300

accttcagac cctggacaat cagacagtac gcgggctttt ccactgtgga agaatctaac      360

aagttctaca aagacaatat aaaggctggc cagcagggac tgagcgtggc attcgatctt      420

gccacacacc gcggctacga ttctgacaac cccagggtta ggggagacgt gggaatggcc      480

ggcgtggcca tcgacaccgt ggaggacaca aagatcctgt tcgacggaat cccacttgag      540

aagatgtcgg tgtccatgac catgaacggg gccgtcatcc ctgtactggc taacttcatc      600

gtgaccgggg aggagcaggg cgtgcccaag gagaagctga caggcaccat acagaacgac      660

atcctgaagg agtttatggt gagaaacacc tatatcttcc ccccagaacc ctcaatgaag      720

atcatcgctg acatctttga gtataccgct aagcacatgc ctaagttcaa tagcatctcc      780

atcagcgggt accacatgca ggaagccggc gccgatgcta tcctggaatt agcttacacc      840

ctggccgacg gactcgagta cagcagaacc ggactgcaag ccggcctgac catcgacgag      900

ttcgctccta ggctgtcctt tttctggggc attggcatga acttctacat ggaaattgcc      960

aagatgaggg ccggccgccg cctgtgggcc cacctcattg agaaaatgtt tcagcccaag     1020

aactccaagt ccttgttgct gagagcccat tgccagacct ccgggtggag cctcacagaa     1080

caggacccct acaataacat tgtgagaacc gccatcgagg ccatggccgc agtcttcggc     1140

ggcacacagt ccctgcacac taactccttt gatgaagccc tgggcctgcc cactgttaag     1200

tctgccagaa tcgcccgcaa cacacaaatc attatccagg aggaatccgg catccccaag     1260

gtggccgacc cttggggcgg gagctatatg atggagtgcc tcaccaacga tgtgtatgat     1320

gccgccctta aactgatcaa cgaaatagag gagatgggcg gcatggccaa agccgtcgcc     1380

gagggcattc ctaagttgag aatcgaggag tgcgccgcca ggagacaggc taggatcgac     1440

agcggcagcg aggtcatcgt gggtgtgaac aagtaccagc tggaaaagga ggacgccgtg     1500

gaggtgctgg ccatcgacaa cacctctgtt aggaacaggc aaattgagaa gctgaagaag     1560

atcaagtcca gcagagacca ggctctggcc gagagatgtc tggccgcact taccgaatgt     1620

gctgccagcg gggacggcaa catactggcg ctcgccgtgg acgccagccg agctagatgc     1680

accgtgggcg aaattacaga cgctttgaaa aaggtgttcg gcgagcacaa ggccaacgat     1740

aggatggtca gcggagccta ccgccaggag ttcggcgagt ctaaggagat cacctcagcg     1800

attaagaggg tgcacaaatt tatggagaga gagggacgga gacccaggct gctggtggcc     1860

aagatgggac aggacggcca cgatagagga gctaaagtca tcgccacagg attcgccgac     1920

ctaggcttcg atgtcgacat cggacccctg ttccaaaccc cccgggaagt ggcccagcag     1980

gctgtggacg ccgatgtgca cgccgtggga gtgtctacac tggccgccgg gcacaagacc     2040

ctggtccctg aacttatcaa agagctcaac agcctcggca gacccgatat cctggtcatg     2100

tgtggcggcg tcataccacc ccaggactat gagttcctgt ttgaagtggg cgtgagcaac     2160

gtctttggcc ctggaaccag gatcccaaag gctgcagtgc aggtgcttga cgacatcgag     2220

aagtgcctgg agaagaagca gcagagcgtg                                      2250


<210>  172
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  172
atgctgcgag ccaagaacca gttgttccta ctgagccccc attaccttcg gcaagtcaag       60

gagagcagcg gcagcagact gatccagcag agactcctcc accagcagca gcccctgcac      120

cccgagtggg ctgccctggc caaaaaacag ttaaaaggaa aaaaccctga ggacttgatc      180

tggcacaccc ccgaaggcat tagcatcaaa cccctgtata gcaagagaga cacaatggac      240

ctgcccgagg agctccccgg cgtgaagccc tttaccagag gcccctaccc caccatgtat      300

acgttccggc catggaccat cagacagtac gccggttttt ctacagtgga agagagcaac      360

aagttctaca aagacaatat taaagccggc cagcagggcc tgtcagtcgc cttcgatctg      420

gccacccacc gtggctacga tagcgacaat cctcgagtga gaggagatgt gggaatggct      480

ggagtggcta ttgacaccgt cgaggacacc aaaattctgt tcgacggcat cccactggag      540

aagatgtccg tgtccatgac catgaacggc gccgttattc ccgtactggc taacttcatc      600

gtgacgggcg aggagcaagg ggtgcccaag gagaagctta caggcaccat ccagaatgat      660

atcctgaagg agttcatggt gagaaataca tacatcttcc cccctgagcc cagcatgaag      720

atcattgccg atatcttcga gtacaccgca aagcacatgc ccaaatttaa cagcatctcc      780

atcagcggat accacatgca ggaggccggc gccgatgcta tcctcgagtt ggcttacaca      840

ctcgccgacg gtttggagta cagtcgcacc gggctgcagg ctggtcttac cattgacgag      900

tttgcccctc ggctcagctt cttctggggc atcggcatga atttctacat ggagattgcc      960

aagatgagag caggacgaag actttgggcg cacctcatcg aaaagatgtt ccaacccaag     1020

aatagcaaat ctctcctgct gagggcccat tgtcagacct ccggctggtc tcttaccgag     1080

caggatcctt acaataacat tgtcagaaca gcaattgaag caatggccgc tgtgttcggc     1140

ggcactcaga gcttgcatac taactctttc gacgaggctc tgggcctgcc taccgtgaaa     1200

agcgccagaa ttgctcgaaa tacacagatc atcatccagg aggaatccgg cattcccaag     1260

gtggccgacc cctggggagg cagttatatg atggagtgcc tgaccaatga cgtgtacgac     1320

gccgcactga aactgattaa cgagatagaa gaaatggggg gcatggccaa agccgtggcc     1380

gagggcatcc caaagctgag aatcgaggaa tgcgccgcca ggcggcaggc cagaatcgac     1440

agcggctccg aagtgattgt gggcgtcaac aagtaccagc tggagaagga ggacgccgtg     1500

gaggttctgg ccatcgacaa caccagcgtg aggaacaggc agatcgagaa gctgaaaaag     1560

atcaaaagct cacgcgatca ggccctggcc gagaggtgtc tggccgccct gacagagtgt     1620

gctgcaagcg gcgatgggaa tatcctggca ctggctgtcg acgcttcccg cgcaagatgt     1680

accgtgggcg agatcaccga tgccctgaaa aaggtgttcg gcgagcacaa ggccaacgac     1740

cggatggtga gcggcgccta cagacaggag tttggcgagt ccaaggagat tacaagcgct     1800

attaaaaggg tccacaagtt tatggagcga gagggaagaa ggccaagact gctggtcgct     1860

aaaatgggtc aggacggtca cgataggggg gccaaggtta tcgccaccgg cttcgccgat     1920

ctgggcttcg acgtggacat tggccccctg tttcagaccc ccagagaggt agcccagcag     1980

gccgtggatg ccgacgtgca tgcagtgggc gttagcaccc tggccgcggg ccataaaacc     2040

ctggtccccg agttaattaa agagctgaac tctctgggac ggcctgacat cctggtgatg     2100

tgcggcggcg tgatcccgcc ccaagactac gagtttctgt tcgaggtggg cgtgtctaat     2160

gtgtttgggc ctggcaccag aatccctaag gcagctgtgc aggtgctgga cgacatcgag     2220

aagtgcctgg agaaaaagca gcagtcagtc                                      2250


<210>  173
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  173
atgcttcgag ccaagaacca gctgtttctt ctgagccccc attatctgag acaggtcaag       60

gagagctcag gcagcagact catccagcag agactgctac accaacagca gccgctccac      120

cccgagtggg ccgccctggc caaaaagcag ctcaagggca agaatcccga ggatctcatt      180

tggcacactc ctgagggtat cagcatcaag ccgctctaca gcaagagaga cacgatggat      240

ctgccggagg agctgcccgg cgtgaagccc tttacgaggg gcccgtaccc caccatgtac      300

acattcagac cctggaccat caggcagtac gccggcttct ccaccgtcga ggagagtaat      360

aaattctaca aagataatat caaggccggc cagcaaggcc tcagcgtcgc cttcgacctg      420

gcaacccatc gcggttacga ttcagataat ccacgtgtga gaggagacgt aggcatggca      480

ggcgtggcca tcgacaccgt ggaggacacc aagatcctgt tcgacggcat tcccctggag      540

aagatgagcg tcagcatgac aatgaatggc gctgtaattc ccgtgctcgc taatttcatc      600

gtgacaggcg aggagcaggg agtgcccaaa gaaaagctga ctggcactat ccagaacgac      660

atcctgaaag aattcatggt gcgtaacaca tacatcttcc ctcccgaacc cagcatgaag      720

atcattgcag acattttcga atacaccgcc aaacatatgc ccaagttcaa cagcatatct      780

attagcggct accatatgca ggaagccggg gcagatgcca tcctggaact ggcatacaca      840

ctggccgacg ggctcgagta ctccagaacc gggctgcagg ccggactaac catcgatgag      900

tttgctccca gactgagctt tttctggggc atcggcatga acttttacat ggagattgcc      960

aagatgaggg ctgggagaag attgtgggcc caccttatcg agaagatgtt tcagcccaag     1020

aacagcaagt ccctgctcct cagagctcat tgtcagacga gcggatggtc cctcaccgag     1080

caggacccct acaacaacat cgtgaggacc gctattgagg ctatggctgc cgttttcggg     1140

ggcacccagt cactgcacac aaactccttc gatgaggccc tgggcctgcc caccgtgaag     1200

tctgcccgga tcgctaggaa cactcagatt attatccagg aggagagcgg aattcccaag     1260

gtcgccgacc cttggggcgg ctcttacatg atggaatgtc tgaccaatga cgtgtatgac     1320

gccgccctga agctaatcaa cgagatcgaa gaaatgggcg gtatggccaa ggccgtggcc     1380

gagggtatcc ctaagctgcg gatcgaagag tgcgctgcta ggagacaggc cagaatagac     1440

agtgggagcg aggtcatcgt gggcgtgaat aagtatcaac tcgagaagga ggacgccgtg     1500

gaagtgctcg ccattgacaa tacctccgtg agaaaccggc agatcgaaaa actaaagaag     1560

atcaagagca gtagggacca ggctctggca gagaggtgcc tggccgcgct gaccgagtgc     1620

gccgcaagcg gcgacgggaa catcctcgca ctggccgtgg acgccagcag agctcggtgt     1680

acagtgggag agatcaccga cgcccttaaa aaggtgtttg gcgagcataa ggcgaacgat     1740

cgcatggtta gcggagctta cagacaggag tttggtgaga gcaaggagat cacgagtgct     1800

atcaagaggg tgcacaaatt catggagcgc gagggcaggc gccctagact cctcgtcgcc     1860

aagatgggtc aggacggtca cgacaggggc gcaaaggtga tcgccaccgg ctttgccgac     1920

ctaggcttcg acgtggacat tggccccctc ttccagacgc ccagagaagt ggcccagcaa     1980

gctgtggacg ccgatgtgca cgcggtggga gtgagcacac tcgccgccgg ccacaagacc     2040

ctggtgcccg agctgattaa ggagctcaac tcactgggga gacccgacat cctggtcatg     2100

tgcggtggag tgatcccccc ccaagactat gagtttctct tcgaggtagg cgtgagtaac     2160

gtgttcgggc ccggcaccag aatccctaag gcggccgtcc aggtgctgga cgatatcgag     2220

aaatgtctgg agaagaagca gcagagcgtt                                      2250


<210>  174
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  174
atgttaagag ccaaaaacca gctgttcctt ctgagccccc attatctgcg gcaggtgaag       60

gaatccagcg gctccagact catccaacag aggctcctac accagcagca gcccctgcac      120

ccggagtggg cagctctggc aaagaagcag ctcaagggca agaaccccga agatctgatc      180

tggcacaccc ccgaaggaat cagcatcaag cctctctata gcaagagaga taccatggat      240

ctgcccgagg agctgcccgg agtgaagcct tttactcggg gaccttaccc cactatgtac      300

actttccgcc cctggaccat cagacagtac gcgggcttct cgaccgtgga agagagtaat      360

aagttctata aagacaacat caaagccggc cagcagggtc tcagcgtggc gttcgatctg      420

gctacacaca gagggtacga tagcgacaac ccaagggtga ggggggacgt gggcatggcg      480

ggggtggcca tcgataccgt ggaagacacc aagatcctgt tcgacggtat ccccctagag      540

aaaatgtcag tcagcatgac gatgaacggc gcagtaatcc ccgtgctcgc aaatttcatt      600

gtgaccggcg aggagcaggg ggtgcctaag gagaagctga ccggcaccat acagaacgat      660

attctgaagg agttcatggt aaggaataca tacatcttcc ctcctgagcc cagcatgaag      720

atcatcgccg acatcttcga gtacactgcg aagcacatgc ccaaatttaa ttccatatcc      780

atctcgggct accacatgca ggaagccggc gccgatgcaa tactggaact ggcttacacc      840

ctggccgacg ggctggagta cagcaggacc ggcctccagg cgggcctgac cattgacgaa      900

tttgccccca gactcagctt cttctgggga atcgggatga atttttacat ggagatcgcc      960

aaaatgagag caggcaggag actgtgggct cacttgatcg agaaaatgtt tcagcccaag     1020

aacagcaaaa gccttctgct cagagcccac tgccagacta gcggctggtc tctgaccgag     1080

caggacccct ataacaacat cgtgagaacc gccatcgagg ccatggccgc cgtgttcggc     1140

ggaacacagt ctctgcatac caactccttc gacgaggcgc tgggactgcc aacggtcaag     1200

agcgcccgca ttgcaaggaa cacccagata atcatccagg aagagtctgg aattcctaag     1260

gtggcggacc cctggggagg ctcttacatg atggaatgcc tgacaaatga tgtctatgac     1320

gctgcactga aactgatcaa cgagattgag gagatgggtg gcatggccaa ggccgtggcc     1380

gagggcatcc caaaactgag aatcgaagag tgtgccgccc ggagacaagc caggatcgac     1440

tccggaagcg aagtgattgt gggagtcaat aagtaccaat tggaaaagga ggacgccgtg     1500

gaggtgctag ctatcgacaa tacctccgtg cgcaacaggc aaatagagaa gctgaaaaag     1560

atcaagtcat cccgggatca agccctggct gagaggtgtt tggccgccct cacggaatgc     1620

gctgccagcg gcgacggaaa catcctggcc ctggccgtcg acgccagcag agccaggtgc     1680

accgtgggtg aaattaccga cgctctgaag aaggtgttcg gtgaacacaa agccaacgac     1740

agaatggtga gcggtgccta cagacaggag ttcggcgagt ccaaggagat cacttcggcc     1800

atcaagaggg tgcacaagtt tatggagcgg gagggcagga ggcccagact cctagtggca     1860

aaaatggggc aggacggcca tgataggggg gccaaagtga tcgccaccgg attcgcagac     1920

ttgggcttcg acgtggatat cggacccttg tttcagaccc cccgcgaagt cgcacagcag     1980

gcggtggacg cggatgtgca cgctgttggc gttagcacac tggctgccgg ccataaaacc     2040

ctggtgcctg agctgattaa ggaactgaac agtctcggac ggcccgatat ccttgtgatg     2100

tgcggaggcg ttatccctcc ccaggactac gagttcttgt tcgaggtggg cgtgagcaat     2160

gtctttggtc caggaactag gattcccaag gctgccgtgc aggtgctgga cgacatcgaa     2220

aagtgccttg agaagaagca gcagtctgtg                                      2250


<210>  175
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  175
atgctgaggg ctaaaaacca actgttcctg ctgagccccc actacctgcg ccaggtgaaa       60

gagtctagcg gtagcaggct catccagcag aggctgctgc atcagcagca gcccctccac      120

cccgagtggg ctgccctcgc caagaaacag ttaaagggga agaatcccga ggacctgatt      180

tggcacaccc cggagggcat cagtattaag cctctgtaca gcaagagaga caccatggac      240

ctgcccgagg aactccctgg ggtgaagccc ttcaccaggg gaccctatcc gaccatgtac      300

acattcaggc cttggaccat cagacagtat gcaggcttca gcaccgtgga agagagcaac      360

aagttctaca aggataatat caaggccgga cagcagggac tgagtgtggc cttcgatctt      420

gccacccaca gaggctatga ctctgacaat cccagagttc gtggggacgt tgggatggcc      480

ggagtggcca ttgatacagt ggaggacacc aagatcctgt ttgacgggat cccgctggag      540

aaaatgagcg tgtccatgac tatgaacggg gcagtgatcc cagtgctggc taacttcata      600

gtgactggag aggagcaggg cgtgccgaag gagaagctca caggcaccat ccagaatgac      660

atcctgaaag aattcatggt gcgtaatact tacatattcc ccccagagcc cagcatgaaa      720

atcatcgcgg acatttttga gtacaccgcc aagcacatgc ccaaatttaa ctcaattagc      780

attagtggct atcatatgca ggaggccggt gccgacgcaa tcctggaact ggcttacacc      840

ctggctgacg gccttgagta tagccggaca ggcctgcagg caggcctgac tatcgatgaa      900

tttgccccac gcctgtcttt cttttggggc atcggcatga acttttacat ggagattgct      960

aagatgcgcg ctggcagaag actctgggcc cacctgattg agaagatgtt ccagcccaag     1020

aactcaaagt ccctgctgct gagggcccac tgtcagactt ctggatggag cctgaccgag     1080

caggatccct ataacaacat cgtgcgtacc gccattgaag ccatggctgc tgtattcggc     1140

ggtacccaga gcctgcatac caacagcttc gatgaggccc tgggcttgcc caccgtgaag     1200

tctgcacgta tcgcccggaa cacccagatc atcatccagg aggaatccgg catccccaag     1260

gtggccgacc cctggggagg cagctacatg atggaatgcc tcaccaacga cgtgtacgac     1320

gccgctctca agttaatcaa tgagatcgag gagatgggcg gcatggccaa agctgtggca     1380

gagggaatcc caaagctgag gatcgaggag tgcgccgcta gaaggcaggc ccgcatcgat     1440

agcggctcag aggtgatcgt gggcgtgaat aagtatcagc tggagaaaga agacgccgtg     1500

gaagtgctgg cgatcgacaa tacctccgtg cgaaacagac agatcgagaa gctgaagaag     1560

atcaagtcga gccgcgacca ggccctggcc gagagatgtc tggcagccct gaccgagtgc     1620

gcagccagcg gcgacggcaa tatcctggcc ctggccgtgg acgcctcccg cgcgaggtgc     1680

acggtgggcg agattacgga cgctttgaaa aaggtgttcg gcgagcacaa ggccaatgac     1740

aggatggtgt ccggggccta tcgacaagaa ttcggggaga gcaaagaaat cacctccgcc     1800

attaagagag tccacaagtt catggagaga gagggccgga gacccagact tctggtcgcc     1860

aagatgggcc aagacggcca tgataggggc gcaaaggtga tcgccaccgg atttgccgac     1920

ctgggcttcg acgtggatat cggacctctt ttccagactc ccagagaggt ggcccagcag     1980

gccgtagacg ccgacgtgca tgctgtaggt gtgagcacgc tggccgccgg ccataagacc     2040

ctggtccccg aactaatcaa ggagctgaac tccctcggca gacccgacat cctggtgatg     2100

tgtggcggcg tgatcccccc acaggactat gagttcctgt ttgaggtagg cgtgagcaac     2160

gttttcggcc caggaaccag gatccctaag gctgccgtgc aggtgctgga tgacatcgaa     2220

aagtgcctgg agaagaagca gcaatcagtt                                      2250


<210>  176
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  176
atgcttagag ccaagaatca gctcttcctg ctgagccccc attatcttag acaggtgaag       60

gagagttcgg gctctcggct gatccagcag agactgctgc accagcagca gccattgcac      120

cccgagtggg ccgcgctggc gaagaaacag ctgaagggca agaaccccga ggatctgatc      180

tggcacacac cagaaggcat cagcatcaag cccttgtata gcaagcggga cacaatggat      240

ctccccgagg agctgcccgg cgtaaagccc ttcactcgag gcccctaccc tacgatgtac      300

accttcagac catggactat tcggcagtac gctggattct ccaccgtgga ggaatctaat      360

aaattctata aggataatat caaggccggc cagcagggcc tgagtgtcgc gttcgacctg      420

gccacccata ggggatacga ctcagacaac cccagggttc ggggcgacgt gggcatggcc      480

ggcgtcgcca tcgacaccgt agaggacaca aaaatcctgt tcgacggcat tcccctggag      540

aaaatgagtg tgagcatgac tatgaacggc gcagtgattc ccgtgctggc caatttcata      600

gtgacagggg aggaacaggg ggtccccaaa gagaaactca ccggcaccat tcaaaacgac      660

attctgaagg aattcatggt gcggaacaca tacattttcc cccccgaacc aagcatgaag      720

atcattgctg atatcttcga gtacacagcg aagcacatgc caaagttcaa ctctatttct      780

atctccgggt atcacatgca ggaggcagga gccgatgcca tcctggagct ggcttacacc      840

ctggcagacg gcctcgagta ctcgcgaacc ggactgcagg ccggcctcac catcgatgag      900

tttgcacccc ggctcagctt cttctggggc atcggtatga acttttatat ggagatcgct      960

aagatgcgcg caggtcgtag actttgggcc cacctcatcg aaaaaatgtt tcaacccaag     1020

aattccaaat ccttgctgct tagagcccat tgccagacat ccggctggag tctgaccgag     1080

caggacccct acaacaacat tgtgagaaca gcgatcgagg caatggccgc cgtgttcggc     1140

ggaacccaga gcctccatac caactccttt gacgaggccc tcggactgcc aaccgtcaag     1200

agcgccagga tcgccagaaa cacccagatc atcatccagg aggagagcgg cattccaaaa     1260

gtggccgatc cttggggcgg ctcctacatg atggagtgcc tcactaatga tgtgtacgac     1320

gccgccctga agctgattaa cgagattgag gagatgggcg gaatggctaa ggccgtggct     1380

gaagggatcc ccaaattgag aattgaggaa tgcgccgcta gaaggcaggc tcgcatagac     1440

tcaggctccg aggtcatcgt gggcgtcaat aaatatcagc tggagaagga ggacgctgta     1500

gaggtgctgg caattgataa cacctctgtg cggaacagac aaattgaaaa attaaagaaa     1560

attaagagca gcagagacca agccctggcc gagcgctgcc tggccgccct gaccgagtgc     1620

gccgccagtg gcgacggaaa cattctagca ctggctgtgg acgcctcgcg tgcgagatgc     1680

accgtgggcg agataacaga cgccctgaag aaggtgttcg gcgagcacaa ggccaacgat     1740

aggatggtgt ctggagccta tagacaggag tttggcgaaa gcaaagagat cacaagcgct     1800

attaagagag tgcacaagtt tatggagaga gaaggccgca gacccagact cctggtcgcc     1860

aagatgggac aggacggtca cgaccggggt gccaaagtaa tcgctaccgg ctttgccgac     1920

ctgggcttcg acgtcgatat tggcccttta ttccagaccc cgcgggaggt agctcagcaa     1980

gccgtcgacg ctgatgtgca cgccgtggga gtgtctaccc tggccgccgg acacaagacg     2040

ctggtgcccg agctgatcaa ggaactgaat agcctgggca gaccggacat cctggttatg     2100

tgcggagggg tgattccccc acaggattac gaattcctct tcgaggtggg ggtgtcaaat     2160

gtgttcgggc ccggaactag aatccccaag gccgccgtgc aggtgctcga cgacatcgaa     2220

aagtgtttgg agaagaagca gcagagcgtc                                      2250


<210>  177
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  177
atgctgagag ccaaaaacca actcttcctg ctgagcccac actacctgcg ccaggtcaag       60

gagtcaagcg gcagcagact gatccagcag agactgctcc accagcagca gcccctgcat      120

cctgagtggg ccgctctggc caaaaaacag ctgaagggca agaaccccga ggacctgatc      180

tggcacaccc ccgagggcat cagcatcaaa cccctgtatt caaagcggga cacaatggac      240

ctccctgagg agctgcctgg cgtcaagcca ttcacgaggg gcccataccc caccatgtac      300

acgttcaggc cctggaccat ccggcagtat gccggattca gtaccgtcga ggagtctaac      360

aagttttaca aggacaacat caaggcagga cagcagggcc tgtctgttgc atttgacctc      420

gccacacacc gaggctacga cagcgataac cccagagtca ggggcgatgt gggcatggcc      480

ggcgtggcca tagacacagt ggaggatacc aagatcctgt tcgatgggat cccactggag      540

aagatgtccg tgagcatgac aatgaatggc gccgtcatcc ccgtgctggc taatttcatt      600

gttaccggag aagagcaggg agtgccaaag gagaaactga ccggcaccat ccagaatgat      660

atccttaagg aattcatggt taggaacaca tacattttcc cacccgagcc atctatgaag      720

attattgccg acatcttcga atataccgcc aagcacatgc cgaaattcaa ctctatctca      780

atcagcgggt accatatgca agaggccgga gccgatgcta tcctggaact cgcttacacc      840

ctggccgacg gcctggagta cagcagaact ggcctgcaag ctggactgac tatcgatgag      900

ttcgcgccgc ggctgagctt cttctggggc atcggcatga acttttatat ggagattgcc      960

aaaatgcgcg ccggcaggag actctgggcc cacctgatcg agaaaatgtt ccagcccaaa     1020

aacagcaaaa gcctgcttct gcgtgcccat tgccaaacca gcggctggtc tctgactgaa     1080

caggaccctt acaacaatat cgtgaggacc gccattgagg ccatggccgc cgtgtttggt     1140

ggcactcaga gcctgcacac caattctttc gatgaagccc tgggcctgcc cacagtgaaa     1200

tccgccagaa tcgccagaaa cacacagatc atcatccagg aggagagcgg catccccaaa     1260

gttgctgacc cctggggcgg ctcctacatg atggagtgcc tcaccaacga cgtgtacgac     1320

gcagctttga aacttatcaa cgagattgag gagatgggag gaatggcgaa ggccgtggcc     1380

gagggtattc ccaagctgag gattgaagaa tgcgcagcca gaagacaggc acggatcgat     1440

tccggcagtg aagtgattgt tggagtgaac aagtaccagc tggagaaaga ggacgccgtg     1500

gaagtcctgg ccatcgataa tacaagcgtg agaaacagac agattgaaaa gctgaagaag     1560

atcaagtcta gccgcgatca ggctctggcc gagagatgcc tggccgccct caccgaatgc     1620

gcagccagcg gcgatgggaa catcctcgca ctggctgtcg acgcttccag agctagatgc     1680

accgtgggtg agatcacgga cgctctgaag aaggtgttcg gcgagcacaa ggccaacgac     1740

aggatggtga gcggtgcata ccgtcaggaa tttggtgagt ccaaggaaat tacctccgca     1800

atcaagagag tgcacaaatt catggaaagg gaaggtcgaa gacctagact gctggtcgcc     1860

aagatggggc aggacggcca tgataggggc gccaaggtca tagctaccgg gtttgcggac     1920

ctgggcttcg acgtggacat cggccctctc ttccagaccc cccgggaagt ggcccagcaa     1980

gccgtggacg ctgacgtgca cgctgtcgga gtgtccaccc tggctgcagg acacaagacc     2040

ctggtgcccg agctcattaa agagctgaac tctctgggcc gccccgacat tctcgtgatg     2100

tgcggcggcg tgatcccccc tcaggattac gagttcttgt ttgaagtggg cgtgagcaac     2160

gtgttcggcc ctggcaccag aattcctaaa gccgcagtcc aggtgctcga tgacatcgag     2220

aaatgcctgg agaaaaaaca gcagagcgtc                                      2250


<210>  178
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  178
atgctaaggg cgaagaacca gttgttcctc ctcagcccac attatctgag gcaggtgaag       60

gagagcagtg gatcaaggct gattcagcag aggctgctgc accagcagca gcccctgcac      120

ccagagtggg ccgccctggc taagaagcag ctgaaaggca agaaccccga ggatttgatt      180

tggcacaccc cagagggaat ctctatcaag cctctgtaca gcaaacgcga cacaatggac      240

ctgccagagg agctgccagg cgtgaagcct ttcacacggg ggccttaccc taccatgtac      300

acattcagac cctggaccat cagacagtac gccggcttct ccaccgttga ggagtccaat      360

aagttctaca aggacaacat taaagccgga cagcagggcc tcagcgtggc ctttgacctc      420

gccacccaca ggggctacga cagcgataac ccccgtgtga gaggggacgt gggaatggcc      480

ggggttgcta tcgatactgt ggaggacact aagatcctct ttgatggcat tcccctggaa      540

aagatgagcg tctctatgac catgaacggg gccgtgatcc ccgtgctggc caactttatc      600

gtgactggcg aggagcaggg ggtgccaaaa gagaagctga caggaaccat tcagaacgac      660

atcctgaagg agtttatggt caggaacacc tacattttcc cccctgagcc aagcatgaag      720

atcatcgccg atattttcga gtataccgcg aagcacatgc ctaaattcaa ctctatcagc      780

atcagcggct accacatgca ggaggccggc gcggatgcca ttctggagct ggcctacaca      840

ctggccgacg gcctcgaata cagccggact ggcctgcagg ctggcttgac aatcgacgag      900

ttcgctccaa gactgagctt cttctggggc atcgggatga acttctatat ggagatcgct      960

aagatgagag ccggaagaag actgtgggct cacctgatag agaagatgtt tcagcctaag     1020

aattctaaga gtctgctgct gagggcgcac tgccagacta gcggctggtc cctgaccgag     1080

caggatccat ataacaacat cgtgagaaca gctattgaag ccatggccgc cgtgtttggc     1140

ggaacacaga gcctccacac caactctttt gacgaggctc tgggattgcc caccgtgaag     1200

agcgccagaa tcgccagaaa tacccagatc atcattcagg aggagtcagg catccccaag     1260

gtggctgacc cctggggcgg gtcttacatg atggagtgtc tgaccaacga cgtatacgac     1320

gccgccctca agcttattaa tgaaattgag gagatgggtg gcatggccaa agctgtggca     1380

gagggcatcc ccaaactgcg gatcgaggag tgcgccgcca gacggcaagc aaggattgac     1440

agcggctctg aagtgatcgt cggcgtcaat aagtatcagc tggagaagga ggacgccgtg     1500

gaggtactgg ccatagacaa cacctctgtg cggaaccgcc agatcgagaa gcttaagaag     1560

atcaagagca gtagagatca ggcactggct gaaaggtgcc tcgctgctct gactgaatgt     1620

gctgcctctg gcgatggcaa catcctggcc cttgccgtgg acgcttcacg ggccaggtgc     1680

acagtgggag agattaccga cgccctgaag aaagtgttcg gtgagcacaa ggccaacgac     1740

cgtatggtga gcggcgctta ccggcaggag ttcggcgaat ccaaggagat caccagtgcc     1800

atcaagagag tccacaagtt tatggaaaga gagggccgca ggcctcggct cctggtggct     1860

aagatggggc aggatggaca cgacaggggc gccaaggtga tcgctactgg cttcgccgac     1920

cttggctttg acgtggatat cggccccctg ttccagaccc ccagggaggt ggcccagcaa     1980

gcggtggacg cggacgtgca cgctgtgggc gtgagcacac tggccgccgg ccacaagact     2040

ctggtgcccg agctgatcaa agagcttaac tcactcggcc gcccagacat tctggtaatg     2100

tgcggcggag tcatcccacc ccaagactat gaattcctgt tcgaagtggg agtgagcaat     2160

gtgttcggcc ctggcaccag aatccccaaa gctgccgtgc aggtcttgga tgacatcgag     2220

aaatgcctgg agaagaagca gcaaagtgtc                                      2250


<210>  179
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  179
atgctgaggg ccaaaaacca gctgttcctg ctcagccctc attacctaag acaggtcaag       60

gagagctccg gcagcagact gatccagcag cgattactgc accagcagca gccgctgcac      120

cccgagtggg ccgccctcgc caaaaagcag ctgaagggca agaacccaga ggacctcatt      180

tggcataccc ccgagggcat aagcattaag cccctctatt ctaagaggga taccatggac      240

ctgcccgaag agctgcccgg cgtcaaaccc tttaccaggg ggccttaccc gactatgtac      300

acattcagac cctggactat cagacagtac gcagggttct ccacggtcga agagagcaac      360

aagttctaca aggacaacat caaagccggc cagcaagggc tcagcgtcgc attcgacctg      420

gctacccaca ggggctacga ctctgacaac cctagagtga gaggggacgt ggggatggct      480

ggagtcgcca tcgacaccgt ggaggacacc aagatcctct ttgatgggat cccactggag      540

aaaatgtccg tgagcatgac catgaatggg gccgtgatcc ctgtgttagc caactttatc      600

gtgacaggag aggaacaggg ggtgcccaag gaaaagttga ccggcaccat ccagaacgat      660

atcctgaaag agttcatggt taggaatacc tacatcttcc cccccgagcc ctctatgaag      720

atcatcgccg acatatttga atataccgcg aaacacatgc ccaagttcaa cagcatttct      780

atcagcggct accacatgca ggaagccggc gctgatgcca tcctggagct cgcctacaca      840

ctggcggatg gcctggagta cagcagaaca ggcctccagg ctggcctgac catcgatgag      900

ttcgcacccc gcctttcctt cttctgggga attggtatga atttttacat ggaaatcgcg      960

aagatgcgcg ccggcaggag actgtgggca catctgatcg agaagatgtt tcagcctaag     1020

aacagtaaat cgctgctgct gcgggcccat tgccagacgt ccgggtggtc actgaccgaa     1080

caggatccct acaacaacat cgtcagaact gccatcgagg ccatggccgc cgtgttcggg     1140

ggaacccaat ccctgcacac caattctttc gacgaggcac tgggcctgcc caccgtgaag     1200

agcgccagaa ttgcccggaa tacccagatt atcatccagg aagaatccgg catccccaag     1260

gtcgcggacc cctggggcgg ctcttacatg atggaatgct taaccaacga cgtatacgac     1320

gccgccctga aacttatcaa cgaaatcgag gagatgggcg gaatggcaaa ggctgtggcc     1380

gagggaatcc ccaagctgag aatcgaggag tgcgccgcca ggagacaggc cagaatagac     1440

agcgggtcag aggtaatcgt gggggtgaac aagtatcaac tggagaagga ggacgccgtg     1500

gaggtgctcg ctatcgacaa cacatccgtg agaaacagac agatcgagaa actgaagaaa     1560

attaaaagca gcagagacca ggcactggcc gaaagatgcc tggcagcact gaccgagtgc     1620

gctgctagcg gcgacggaaa catcctggcc cttgctgtgg acgcctcaag ggcacgctgc     1680

actgtaggcg agatcaccga cgccctcaag aaggtgttcg gggagcacaa ggcgaatgac     1740

agaatggtga gcggtgccta ccgccaggag tttggagaga gcaaggaaat aaccagcgcc     1800

attaagagag tgcacaagtt tatggagaga gagggcaggc ggcccaggct gctggtggca     1860

aagatgggcc aggacggaca cgaccggggc gctaaagtta tcgcgacagg ctttgctgac     1920

ctgggattcg atgttgacat tggccccctg ttccagacac cccgggaggt tgcccagcag     1980

gccgtggatg ccgacgttca cgccgtgggc gtcagcacac tggccgccgg ccataagacc     2040

ctggtgcccg agctgatcaa ggagctgaat agcctgggtc gacccgatat cctggtgatg     2100

tgcggcggag tgatccctcc ccaggattat gaattcttgt ttgaggtggg agtgagcaac     2160

gtttttggcc ctggcacccg tatccccaag gccgccgttc aggtactgga cgacatcgaa     2220

aaatgcttag agaagaagca gcagtcagtg                                      2250


<210>  180
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  180
atgctgcgag cgaaaaacca actgtttctg ctgtcccccc attacctgcg ccaggtgaag       60

gagtccagcg gaagccggct catccaacag cggctgctgc accagcagca gcccctgcac      120

cccgagtggg ccgcactggc caagaaacag ctgaaaggca aaaaccccga agacctgatc      180

tggcacacgc ccgaaggcat cagcatcaag cccctctact ccaagcgcga taccatggat      240

ctgcccgagg agctccccgg cgtgaagccc tttaccaggg gcccctatcc caccatgtac      300

accttccggc cctggaccat caggcagtac gccggattca gcacagtgga ggagagcaac      360

aaattttaca aggacaatat caaagccggg cagcaaggcc tgagcgtcgc cttcgacctg      420

gcgacacaca gggggtacga cagcgacaat ccgcgggtca ggggcgacgt cggaatggca      480

ggcgtggcca tcgacaccgt ggaggacacc aaaatcctgt ttgacggcat ccccctcgag      540

aagatgagcg tgtccatgac catgaacggc gcagtgatcc cggtgctggc caacttcatc      600

gtcaccgggg aggagcaggg cgtcccgaag gagaagctga ccggcaccat acaaaacgac      660

atactgaagg aattcatggt gaggaacacg tacatctttc cccccgaacc cagcatgaag      720

atcatcgcag atattttcga gtataccgcc aagcacatgc ccaagttcaa ctccatctcg      780

atcagtgggt accatatgca agaagccggg gccgacgcca tcctggagct cgcctatacc      840

ctggccgacg gcctggagta tagcaggacc ggcctccagg ccgggctgac gatcgatgag      900

tttgccccca ggctgagctt cttctggggg atcgggatga atttttatat ggagatcgcc      960

aagatgaggg ccgggcggag gctgtgggcc cacctgatcg aaaagatgtt ccagcccaag     1020

aactcaaaga gcctgctcct gcgggcccat tgccagacca gcggctggtc cctgaccgag     1080

caggacccct acaacaacat cgtgaggaca gccatcgagg caatggccgc cgtgttcggg     1140

ggcacccaga gcctgcatac caactccttc gacgaggcgc tggggctccc gaccgtgaaa     1200

agcgcccgga tcgcacggaa tacccagatc atcatccagg aggagagcgg catccccaag     1260

gtcgcagacc cctggggcgg ctcctacatg atggagtgtc tcaccaacga cgtgtacgac     1320

gccgccctga agctgatcaa cgagatcgag gagatggggg ggatggccaa ggccgtagcc     1380

gagggcatcc ccaaactgag gatcgaagag tgcgccgccc gccggcaggc gaggatcgac     1440

agcggcagcg aggtgatcgt gggggtgaac aaataccagc tggagaagga ggatgccgtc     1500

gaggtgctgg ccattgacaa cacctcggtc cggaacaggc agatcgagaa gctcaagaag     1560

atcaagagca gtcgagacca ggccctggcc gagaggtgcc tggccgccct gacagaatgc     1620

gcagccagcg gcgacggaaa catcctggcg ctggccgtgg acgccagtcg ggccaggtgc     1680

acggtgggcg agatcaccga cgccctgaag aaggtcttcg gggagcacaa ggccaacgac     1740

cggatggtga gcggcgccta ccgacaggag ttcggcgagt caaaggagat aacctccgcc     1800

atcaagaggg tgcacaagtt catggagagg gagggcagga ggcccaggct cctcgtcgcc     1860

aagatgggac aggacggcca tgacaggggc gccaaggtca tcgccaccgg attcgccgac     1920

ctgggcttcg acgtggacat cgggcccctg tttcagaccc cacgggaggt ggcccagcag     1980

gccgtggacg ccgacgtgca cgcggtgggc gtcagcaccc tggccgctgg gcacaagacc     2040

ctcgtgcccg aactgatcaa ggagctgaac tccctgggga ggcccgacat cctcgtgatg     2100

tgcggggggg tgatcccccc ccaggactat gaattcctgt ttgaggtggg ggtgagcaac     2160

gtgttcggcc ccgggactag aatacccaag gccgccgtcc aggtgctgga tgatatcgag     2220

aaatgcctgg agaaaaaaca gcaaagcgtg                                      2250


<210>  181
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  181
atgctgcggg ccaagaacca gctgttcctg ctgagccccc actacctgcg gcaggtgaag       60

gagagcagcg gcagccggct gatccagcag aggctgctgc accagcagca gccgctgcac      120

ccggagtggg cggcgctggc gaagaagcag ctgaagggga agaacccgga ggacctgatc      180

tggcacacgc cggaggggat cagcatcaag ccgctgtaca gcaagaggga cacgatggac      240

ctgccggagg agctgccggg ggtgaagccg ttcacgaggg ggccgtaccc gacgatgtac      300

acgttcaggc cgtggacgat caggcagtac gcggggttca gcacggtgga ggagagcaac      360

aagttctaca aggacaacat caaggcgggg cagcaggggc tgagcgtggc gttcgacctg      420

gcgacgcaca gggggtacga cagcgacaac ccgagggtga ggggggacgt ggggatggcg      480

ggggtggcga tcgacacggt ggaggacacg aagatcctgt tcgacgggat cccgctggag      540

aagatgagcg tgagcatgac gatgaacggg gcggtgatcc cggtgctggc gaacttcatc      600

gtgacggggg aggagcaggg ggtgccgaag gagaagctga cggggacgat ccagaacgac      660

atcctgaagg agttcatggt gaggaacacg tacatcttcc cgccggagcc gagcatgaag      720

atcatcgcgg acatcttcga gtacacggcg aagcacatgc cgaagttcaa cagcatcagc      780

atcagcgggt accacatgca ggaggcgggg gcggacgcga tcctggagct ggcgtacacg      840

ctggcggacg ggctggagta cagcaggacg gggctgcagg cggggctgac gatcgacgag      900

ttcgcgccga ggctgagctt cttctggggg atcgggatga acttctacat ggagatcgcg      960

aagatgaggg cggggaggag gctgtgggcg cacctgatcg agaagatgtt ccagccgaag     1020

aacagcaaga gcctgctgct gagggcgcac tgccagacga gcgggtggag cctgacggag     1080

caggacccgt acaacaacat cgtgaggacg gcgatcgagg cgatggcggc ggtgttcggg     1140

gggacgcaga gcctgcacac gaacagcttc gacgaggcgc tggggctgcc gacggtgaag     1200

agcgcgagga tcgcgaggaa cacgcagatc atcatccagg aggagagcgg gatcccgaag     1260

gtggcggacc cgtggggggg gagctacatg atggagtgcc tgacgaacga cgtgtacgac     1320

gcggcgctga agctgatcaa cgagatcgag gagatggggg ggatggcgaa ggcggtggcg     1380

gaggggatcc cgaagctgag gatcgaggag tgcgcggcga ggaggcaggc gaggatcgac     1440

agcgggagcg aggtgatcgt gggggtgaac aagtaccagc tggagaagga ggacgcggtg     1500

gaggtgctgg cgatcgacaa cacgagcgtg aggaacaggc agatcgagaa gctgaagaag     1560

atcaagagca gcagggacca ggcgctggcg gagaggtgcc tggcggcgct gacggagtgc     1620

gcggcgagcg gggacgggaa catcctggcg ctggcggtgg acgcgagcag ggcgaggtgc     1680

acggtggggg agatcacgga cgcgctgaag aaggtgttcg gggagcacaa ggcgaacgac     1740

aggatggtga gcggggcgta caggcaggag ttcggggaga gcaaggagat cacgagcgcg     1800

atcaagaggg tgcacaagtt catggagagg gaggggagga ggccgaggct gctggtggcg     1860

aagatggggc aggacgggca cgacaggggg gcgaaggtga tcgcgacggg gttcgcggac     1920

ctggggttcg acgtggacat cgggccgctg ttccagacgc cgagggaggt ggcgcagcag     1980

gcggtggacg cggacgtgca cgcggtgggg gtgagcacgc tggcggcggg gcacaagacg     2040

ctggtgccgg agctgatcaa ggagctgaac agcctgggga ggccggacat cctggtgatg     2100

tgcggggggg tgatcccgcc gcaggactac gagttcctgt tcgaggtggg ggtgagcaac     2160

gtgttcgggc cggggacgag gatcccgaag gcggcggtgc aggtgctgga cgacatcgag     2220

aagtgcctgg agaagaagca gcagagcgtg                                      2250


<210>  182
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  182
atgctgcggg ccaagaacca gctgttcctg ctgagccccc actacctgcg gcaggtgaag       60

gagagcagcg gcagccggct gatccagcag cgcctcctcc accagcagca gcccctccac      120

cccgagtggg ccgccctcgc caagaagcag ctcaagggca agaaccccga ggacctcatc      180

tggcacaccc ccgagggcat ctccatcaag cccctctact ccaagcgcga caccatggac      240

ctccccgagg agctccccgg cgtcaagccc ttcacccgcg gcccctaccc caccatgtac      300

accttccgcc cctggaccat ccgccagtac gccggcttct ccaccgtcga ggagtccaac      360

aagttctaca aggacaacat caaggccggc cagcagggcc tctccgtcgc cttcgacctc      420

gccacccacc gcggctacga ctccgacaac ccccgcgtcc gcggcgacgt cggcatggcc      480

ggcgtcgcca tcgacaccgt cgaggacacc aagatcctct tcgacggcat ccccctcgag      540

aagatgtccg tctccatgac catgaacggc gccgtcatcc ccgtcctcgc caacttcatc      600

gtcaccggcg aggagcaggg cgtccccaag gagaagctca ccggcaccat ccagaacgac      660

atcctcaagg agttcatggt ccgcaacacc tacatcttcc cccccgagcc ctccatgaag      720

atcatcgccg acatcttcga gtacaccgcc aagcacatgc ccaagttcaa ctccatctcc      780

atctccggct accacatgca ggaggccggc gccgacgcca tcctcgagct cgcctacacc      840

ctcgccgacg gcctcgagta ctcccgcacc ggcctccagg ccggcctcac catcgacgag      900

ttcgcccccc gcctctcctt cttctggggc atcggcatga acttctacat ggagatcgcc      960

aagatgcgcg ccggccgccg cctctgggcc cacctcatcg agaagatgtt ccagcccaag     1020

aactccaagt ccctcctcct ccgcgcccac tgccagacct ccggctggtc cctcaccgag     1080

caggacccct acaacaacat cgtccgcacc gccatcgagg ccatggccgc cgtcttcggc     1140

ggcacccagt ccctccacac caactccttc gacgaggccc tcggcctccc caccgtcaag     1200

tccgcccgca tcgcccgcaa cacccagatc atcatccagg aggagtccgg catccccaag     1260

gtcgccgacc cctggggcgg ctcctacatg atggagtgcc tcaccaacga cgtctacgac     1320

gccgccctca agctcatcaa cgagatcgag gagatgggcg gcatggccaa ggccgtcgcc     1380

gagggcatcc ccaagctccg catcgaggag tgcgccgccc gccgccaggc ccgcatcgac     1440

tccggctccg aggtcatcgt cggcgtcaac aagtaccagc tcgagaagga ggacgccgtc     1500

gaggtcctcg ccatcgacaa cacctccgtc cgcaaccgcc agatcgagaa gctcaagaag     1560

atcaagtcct cccgcgacca ggccctcgcc gagcgctgcc tcgccgccct caccgagtgc     1620

gccgcctccg gcgacggcaa catcctcgcc ctcgccgtcg acgcctcccg cgcccgctgc     1680

accgtcggcg agatcaccga cgccctcaag aaggtcttcg gcgagcacaa ggccaacgac     1740

cgcatggtct ccggcgccta ccgccaggag ttcggcgagt ccaaggagat cacctccgcc     1800

atcaagcgcg tccacaagtt catggagcgc gagggccgcc gcccccgcct cctcgtcgcc     1860

aagatgggcc aggacggcca cgaccgcggc gccaaggtca tcgccaccgg cttcgccgac     1920

ctcggcttcg acgtcgacat cggccccctc ttccagaccc cccgcgaggt cgcccagcag     1980

gccgtcgacg ccgacgtcca cgccgtcggc gtctccaccc tcgccgccgg ccacaagacc     2040

ctcgtccccg agctcatcaa ggagctcaac tccctcggcc gccccgacat cctcgtcatg     2100

tgcggcggcg tcatcccccc ccaggactac gagttcctct tcgaggtcgg cgtctccaac     2160

gtcttcggcc ccggcacccg catccccaag gccgccgtcc aggtcctcga cgacatcgag     2220

aagtgcctcg agaagaagca gcagtccgtc                                      2250


<210>  183
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  183
atgctaagag caaagaacca gctttttcta ttgtcccccc attatttgag acaagttaag       60

gaaagttcag gctccagact tatccaacag cgacttctcc accagcagca gccactgcat      120

ccggaatggg ccgccctggc aaagaagcag cttaagggaa agaatcctga ggatttaatc      180

tggcacaccc ctgagggcat tagcatcaag cccttgtact cgaagaggga tactatggac      240

ctgcctgagg agctcccagg cgtgaagccg ttcacccgcg gcccctaccc aaccatgtac      300

actttcaggc cctggaccat ccgacagtac gccggttttt ccacagtgga agaatctaat      360

aaattctata aagataacat aaaggccgga cagcaggggc ttagcgtggc attcgatctg      420

gccacgcatc gcggatacga cagcgataac ccaagagtta gaggtgatgt gggtatggcc      480

ggagttgcca ttgatactgt cgaagacaca aagattctct tcgatggcat ccctctggag      540

aaaatgagtg tgtccatgac tatgaacgga gccgtgattc cagtcctcgc taattttatt      600

gtgacgggag aagaacaggg ggttcccaag gagaaactta cggggaccat tcagaacgat      660

atccttaaag aattcatggt tcgcaacaca tacatcttcc caccagagcc ttctatgaaa      720

attatcgcag atatattcga gtacacggcc aagcacatgc ccaaattcaa cagcattagt      780

ataagcgggt accacatgca ggaggcgggg gcagacgcca ttttggaact ggcatacact      840

ttggccgacg gcctcgaata ctctaggacg ggtctgcagg cggggctcac catcgatgaa      900

ttcgcccccc gtctttcgtt cttttggggc ataggaatga acttctacat ggagatagct      960

aaaatgcggg ccgggaggcg cctgtgggca catctgatag agaagatgtt tcaacccaaa     1020

aactctaaat ctttgttgct gagggctcat tgccaaacct caggctggtc cctgaccgaa     1080

caggacccct acaacaatat cgttagaacc gcaatagagg ccatggctgc agtcttcggg     1140

ggaacccagt ctctgcacac caatagcttc gacgaagccc taggccttcc aaccgtcaag     1200

tctgccagga tcgcacgtaa cacgcaaatt atcatacagg aagaatctgg catccctaaa     1260

gtggctgacc cttggggggg gtcctatatg atggagtgct tgaccaacga cgtttacgat     1320

gctgctctaa agctgatcaa tgaaatcgaa gaaatgggcg gcatggccaa agctgtcgcc     1380

gaaggcatcc caaagttgcg tatagaggag tgcgcggcaa gaaggcaggc tcggatagat     1440

tccggatccg aagtgatagt gggcgtcaat aagtatcaac tcgagaaaga ggacgctgtc     1500

gaggtgttgg ccatagacaa cacaagcgtg cgcaaccggc agatcgaaaa actaaaaaag     1560

attaaatcat caagggacca ggccctggcc gagaggtgtc tcgcagcctt gaccgaatgc     1620

gcagcttcag gggatgggaa tatcttggct ctcgccgtgg acgcatctcg tgctaggtgt     1680

acagttggtg aaattacaga cgcactcaaa aaggttttcg gagagcataa ggcaaacgac     1740

cggatggtgt caggagctta cagacaggag tttggggaaa gcaaggaaat cacctcagcc     1800

atcaaacgtg tgcacaagtt catggaaaga gagggtcggc ggccacggct ccttgttgcc     1860

aagatgggcc aagacggcca cgaccgggga gctaaggtga ttgcaaccgg atttgcagac     1920

ctcggctttg atgtcgatat tggaccactc ttccagactc cccgagaggt tgcccagcag     1980

gctgtggacg ccgacgtgca tgcagtggga gtttcaaccc tggctgctgg acataagact     2040

cttgtcccag agctaattaa ggagttgaat tctctcggca gaccagacat tttagtgatg     2100

tgtggtggcg tcattccccc ccaagactat gagtttctct tcgaagtcgg agtctcaaat     2160

gtatttggac caggtactcg catccccaaa gctgctgttc aggttctcga cgatatcgaa     2220

aaatgtctag agaaaaaaca acaaagcgtg                                      2250


<210>  184
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  184
atgctgaggg ctaaaaacca actgttcctg ctatcccccc attacctgcg acaagtaaag       60

gaatcttctg gttcccgcct tattcaacaa aggttgctac atcagcagca gcccttacac      120

cctgagtggg ccgctctcgc taagaagcag ctgaaaggga agaaccccga agaccttata      180

tggcacaccc ctgagggaat cagcatcaag ccgctgtatt ctaaaaggga taccatggac      240

ttgcccgagg agcttcccgg agtgaagcct ttcactaggg gcccctatcc tacgatgtat      300

acatttcgcc catggacaat tagacagtat gcaggattca gtacagttga agagtcaaac      360

aaattctata aggacaatat aaaggccggg cagcagggac tgagcgtggc ctttgatctg      420

gccacccata ggggttacga cagtgacaac cctagggtgc gtggcgacgt aggaatggcc      480

ggggtggcaa tcgataccgt tgaggacacg aaaatacttt tcgacggaat ccccctcgag      540

aaaatgtctg tgtctatgac aatgaacggc gccgtgatcc ccgttctggc aaattttatt      600

gtcacgggag aagagcaggg cgtgccaaag gagaaactga cgggaacaat tcaaaacgac      660

atccttaagg agttcatggt tcgaaacacc tacattttcc ccccagagcc aagtatgaag      720

ataatagccg acatcttcga gtacacggca aagcacatgc ccaaattcaa tagcatctca      780

atcagtggat atcatatgca ggaagctggt gctgacgcta tcctcgagct tgcttacacc      840

ctcgcagacg gactggaata tagtcggacc gggttgcaag ctggtcttac tatagacgaa      900

tttgctccac ggctgtcatt cttttggggg attgggatga atttttacat ggagatcgca      960

aagatgcgcg caggaagacg cctctgggcc cacctaatcg aaaaaatgtt ccagcctaag     1020

aacagcaaga gcctcctgct cagagcccac tgccagacct ccggctggtc tcttacagag     1080

caggacccgt acaataacat tgtgcgcacc gccatcgagg ccatggctgc cgtctttggt     1140

ggcacccaaa gcctccatac taatagcttc gatgaggcgc tgggactccc aaccgtgaag     1200

tccgccagga tagctaggaa cacccagatc atcatacagg aagagtctgg aatccccaag     1260

gttgccgacc cctggggcgg ttcctacatg atggaatgtc tcaccaatga tgtgtatgat     1320

gccgctctaa aattaataaa tgaaatcgag gagatgggcg gcatggccaa agctgtcgct     1380

gaggggatcc cgaaactgag aattgaagaa tgcgccgctc gccggcaagc tcgcatcgat     1440

tcagggtccg aagtaatcgt tggggtgaac aagtaccagc tcgagaaaga ggacgctgtg     1500

gaggtcctcg ccatagataa tactagtgtg cgaaaccgtc agattgagaa gctgaagaag     1560

ataaaatcct cgcgtgacca ggccttggcc gagagatgct tggccgctct caccgagtgc     1620

gccgcaagcg gggatggcaa tatcctcgcc ctggctgtgg atgcaagcag agctaggtgc     1680

acagtagggg aaattactga cgcccttaaa aaagtatttg gagagcacaa ggcaaatgat     1740

cgcatggtct ccggagccta tcggcaagag ttcggcgaat ccaaagagat tacgagtgcc     1800

atcaagcggg tccacaaatt catggagcga gaagggcggc gcccaaggct gctcgtggcc     1860

aagatgggcc aggacggaca tgacagggga gctaaggtga tcgctaccgg tttcgccgac     1920

ctggggtttg atgtcgacat cggtcctctg ttccagactc ctagggaagt cgcacagcag     1980

gccgtggatg ccgatgttca tgccgtcgga gtgtctactc tggcggctgg ccataaaact     2040

ctggtccccg agctgatcaa ggagctgaat tctctgggcc gcccagacat cctcgttatg     2100

tgcggggggg tcatcccacc tcaggactac gaattcctct tcgaagtggg agtcagcaac     2160

gtgtttgggc ccgggacccg tataccaaag gctgccgtgc aggtgctgga tgatattgaa     2220

aagtgtctgg aaaaaaagca gcagtccgtg                                      2250


<210>  185
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  185
atgctgaggg ccaaaaacca actgtttctg ctcagccctc attatctgag gcaggtcaag       60

gaatcatccg gtagccgact gatacagcag cgacttctcc atcagcaaca accacttcac      120

ccagagtggg ccgcccttgc aaagaaacag ttaaaaggaa agaaccctga agatctcatc      180

tggcacacac ccgagggcat ctcaataaag ccgctgtact cgaaacgaga caccatggac      240

ctgcctgaag aactgccggg ggtcaagccc tttactagag ggccctaccc aaccatgtac      300

acatttcgcc cttggactat tcggcaatac gccggcttca gtacggtaga agagtccaat      360

aagttttata aagataatat taaagccgga caacaaggac tgtcggtggc attcgacctg      420

gctacacata gggggtacga tagtgacaat cctagagtcc gcggtgatgt ggggatggct      480

ggcgtggcaa tagacaccgt tgaggacacg aaaatcctgt tcgatggtat ccctttagag      540

aaaatgtccg tttctatgac gatgaacggg gctgtgatcc ccgtcctagc caatttcatc      600

gtcacgggcg aggaacaggg ggttccaaaa gaaaaattga ccggaactat acaaaatgac      660

atactgaagg aattcatggt tcgcaacact tacattttcc ctcctgagcc ttctatgaag      720

ataatagccg acatttttga gtacactgct aagcatatgc ctaagttcaa cagcatctca      780

atatcggggt accacatgca ggaggctgga gccgacgcga ttctcgaatt ggcgtacacc      840

ctcgcggacg gtctggagta ctctaggact ggcctccagg ccggacttac tattgatgag      900

tttgccccga gactgtcctt cttttggggt ataggaatga acttttacat ggagatcgct      960

aaaatgcgcg cgggcagaag actgtgggcc cacctgatcg agaaaatgtt tcaacccaag     1020

aactcaaaga gcttgttatt gagggcccat tgtcaaacct cagggtggtc actgactgaa     1080

caggacccat ataacaacat cgtccgcact gctatcgagg ctatggccgc tgtcttcggc     1140

gggactcaaa gtcttcacac aaactctttc gacgaggctc tgggtctacc caccgtgaag     1200

agcgcccgta tcgcgcgcaa tacccaaatc atcatccagg aagaaagtgg tatccccaag     1260

gtggcagacc catggggcgg cagctacatg atggaatgtc tgaccaacga cgtctatgac     1320

gccgctctga aactgattaa tgagatcgag gagatgggtg gcatggctaa ggcggtcgcg     1380

gaggggatcc caaagttacg gatcgaggag tgcgccgcac gacggcaagc ccgaatcgat     1440

tcaggttcag aggtcattgt gggggtgaac aaataccagt tagaaaaaga ggatgctgtg     1500

gaagtgctgg ccatcgacaa tacatctgtt cgcaaccggc agatagagaa attgaaaaaa     1560

attaagtcat ctcgagacca ggccttagca gaacggtgcc tggctgcact gaccgagtgc     1620

gctgcgtctg gtgatggaaa catactagcg cttgccgttg acgccagccg tgcacgctgt     1680

acagtagggg aaattacaga cgcattaaag aaggtatttg gggagcacaa ggcgaacgac     1740

cgcatggtgt ccggggccta ccggcaggag ttcggagagt caaaggaaat cacctctgcc     1800

atcaagcgcg tgcacaagtt tatggagagg gagggcaggc ggcctcgtct ccttgtcgct     1860

aaaatgggtc aggacggtca tgaccgaggg gccaaggtta ttgcgaccgg tttcgcggat     1920

ctgggcttcg acgtggacat cgggccactc tttcagaccc caagggaagt agcccagcaa     1980

gccgtggacg cagacgtaca cgctgtcgga gtgagcacac tggctgccgg gcataagaca     2040

ttggtgcctg aattgataaa agagctgaac tcactagggc gacctgatat cctcgttatg     2100

tgcggcggcg ttattcctcc acaggactac gaatttctct tcgaggtcgg tgtttccaat     2160

gtttttggtc ccgggactag aatccctaag gcagctgtcc aggttctgga cgacatagag     2220

aagtgccttg agaagaaaca acagtccgtt                                      2250


<210>  186
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  186
atgctaaggg caaaaaacca gcttttcttg ctgagcccgc attacctgag acaggtgaag       60

gagagctccg ggtctcggct gatccagcag agacttctgc accagcagca gcctttgcac      120

ccagagtggg ctgctctggc caaaaaacag ctgaagggta aaaacccaga agatctcatc      180

tggcacactc cagagggcat atcaatcaaa ccactctatt caaagcgaga cacaatggac      240

ttgccagaag agctcccagg ggttaaacct ttcaccagag gaccttaccc aacgatgtac      300

accttcaggc cttggaccat ccgccagtac gcgggcttca gcacagtgga ggagagtaac      360

aagttctaca aggataacat caaggcgggc caacaaggtc tctccgtggc cttcgacctt      420

gccactcaca gagggtatga ctccgacaat ccccgcgtga ggggagacgt gggaatggcg      480

ggggtggcaa ttgacactgt cgaagacacc aagatcctgt ttgacggtat ccctttagaa      540

aaaatgtcag tgtccatgac aatgaacgga gcagtgatac ccgttctcgc caacttcatc      600

gttactggag aggagcaggg ggttccgaag gaaaagctca ccggcacgat ccaaaatgat      660

atcctcaagg aattcatggt ccgcaacaca tatattttcc caccagaacc aagtatgaaa      720

attatagccg atatcttcga atacactgca aagcatatgc cgaagtttaa cagtatctcc      780

atcagcggct accacatgca ggaggctggg gccgacgcca tccttgaact tgcctacacc      840

ctcgccgatg gcctggaata ctcccgcacc gggctgcaag ccggtctgac tatcgacgag      900

ttcgcccctc gcttgagttt cttttggggt ataggcatga acttttacat ggagatagct      960

aaaatgaggg ctgggcgccg gctctgggcc cacctgatag aaaaaatgtt tcagccaaag     1020

aattccaagt ccctcctcct gagggcgcac tgccagacct ctggatggtc tttaaccgag     1080

caagatccat ataataacat cgtgaggacc gcgattgaag ccatggcagc agtctttgga     1140

ggcacccagt cactgcacac caactctttc gacgaggcgc ttggattacc caccgtgaag     1200

tccgcgagaa tagccagaaa tacacaaatt ataattcaag aggagtcggg gattcctaaa     1260

gtggccgacc cttggggcgg gtcatacatg atggaatgtt taactaatga cgtgtacgat     1320

gccgcattaa aactgattaa cgagatcgag gaaatgggag ggatggcaaa ggctgtggcc     1380

gaggggattc caaaactgcg gattgaggag tgtgcggcta gacgccaggc taggattgac     1440

tcaggatcag aggtgatcgt gggggtgaat aaataccagc tggagaaaga ggatgcagtt     1500

gaagtcttag ccattgataa cactagtgtt agaaatcgcc agattgaaaa actgaagaaa     1560

atcaaaagct ccagagatca ggctctagct gaacggtgct tagcagcact gaccgaatgc     1620

gccgccagcg gcgacgggaa tattctagcg cttgccgtag acgccagcag agcccgctgt     1680

actgtaggtg agataactga tgcattgaaa aaagtgttcg gtgaacacaa ggccaatgat     1740

cggatggtca gcggggccta ccggcaagag ttcggcgaaa gcaaggaaat tacgagcgca     1800

ataaagcgtg tgcataaatt tatggagaga gaaggacgcc ggcccaggct gctggttgct     1860

aaaatgggac aggatggcca cgacagaggc gcgaaggtaa tcgcgaccgg atttgcagat     1920

cttggcttcg atgtggatat tggcccactg tttcagaccc cccgagaggt cgctcaacaa     1980

gcggtggacg ccgatgtgca cgctgtgggc gtgtctacgc tcgctgccgg acataagaca     2040

cttgttcctg aactcattaa ggaacttaat tctctgggcc gcccagatat ccttgtgatg     2100

tgcgggggag tgattcctcc gcaggactat gagttcctgt ttgaggttgg tgtatctaac     2160

gtctttggcc ccggcacacg gattcctaaa gcggcggtgc aggtgcttga tgacatcgag     2220

aagtgccttg agaaaaaaca gcagtccgtt                                      2250


<210>  187
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  187
atgctgagag ctaagaacca actgttcctg ctgagccctc actacctgag gcaggtgaag       60

gaaagctccg ggtccaggct gatccagcaa cggctcctgc accagcagca gccactccat      120

cccgagtggg ccgctctggc caaaaagcag ctcaagggca aaaaccccga ggacttaatt      180

tggcacactc ctgagggaat tagcatcaag cctctgtaca gcaagaggga caccatggac      240

ctccccgagg agctgcctgg ggtaaagccc ttcactaggg gcccctaccc caccatgtac      300

acattcagac cctggactat cagacagtac gccggcttct ctactgtcga agagagcaat      360

aagttctaca aagacaacat caaggcaggc cagcagggcc tctccgtcgc attcgacctg      420

gccacgcaca gggggtatga cagcgataac cccagggtgc ggggcgacgt aggaatggcg      480

ggagtggcca ttgacaccgt ggaggatacc aaaatcctct tcgatggcat tccactcgag      540

aagatgtctg tgagcatgac catgaacggg gccgtgatcc ccgttttggc taacttcatc      600

gtcaccgggg aggagcaggg cgtacccaag gagaagctga caggcaccat acagaacgac      660

atcctgaagg agttcatggt ccggaataca tacatctttc ctcccgagcc ctctatgaag      720

atcattgccg acatcttcga gtacaccgcc aagcacatgc ccaagtttaa ctcaatatcc      780

attagcggat atcacatgca ggaagcaggg gccgacgcca ttctggagct ggcctacaca      840

ctggctgacg gactggagta cagccggacc ggcctacagg ccggcttgac catcgacgag      900

ttcgccccta ggctctcttt tttctggggg atcggcatga atttctacat ggagatcgcc      960

aagatgagag cggggcggcg tctgtgggcc cacctgatcg agaagatgtt tcagccaaaa     1020

aactcaaaat cactgctgct ccgcgcccac tgtcaaacaa gcggctggtc ccttaccgag     1080

caggacccct acaacaacat tgtgcggact gctatcgagg ccatggccgc cgtgttcggc     1140

ggaacccaga gcctgcatac caactctttc gacgaggccc ttggtctgcc caccgtgaag     1200

agcgccagaa tcgcaagaaa cacccagatt atcattcagg aggaaagtgg cattcccaag     1260

gttgccgacc cctggggcgg cagctacatg atggagtgcc ttactaatga cgtgtacgac     1320

gccgccctga agctgatcaa cgagatcgag gagatgggtg gcatggctaa agctgtggct     1380

gagggaatcc ctaagcttcg gattgaagag tgcgccgcca gaagacaggc tagaatcgac     1440

tccggatccg aggtaatcgt cggggtgaac aagtatcaac tggagaagga ggacgcggtg     1500

gaagtcctcg ctatcgacaa taccagcgtc aggaaccgcc agattgagaa gctgaagaag     1560

atcaagtctt ccagggacca ggcgctggcc gaaaggtgcc tggccgccct gaccgaatgc     1620

gccgccagcg gcgacggcaa cattctggct ctggctgtgg acgccagccg tgccaggtgc     1680

actgtgggag agatcacaga cgctctgaag aaggtgtttg gagagcacaa ggccaacgac     1740

agaatggtgt caggcgccta taggcaggag tttggcgagt ccaaggagat cacaagcgcc     1800

atcaaaagag tacataagtt tatggagcgt gagggaagaa gaccacgcct gctggttgcc     1860

aagatgggcc aggatggcca cgacagaggg gctaaggtga tagccactgg cttcgccgat     1920

ctgggtttcg atgtggatat cggacccctc tttcagaccc caagagaggt ggctcagcaa     1980

gccgtggacg cagacgtgca cgccgttggg gtaagcaccc tggccgccgg ccacaagacc     2040

ttggtgcctg agctgatcaa ggagctcaat tcccttggcc gcccagatat cctggtaatg     2100

tgtggcggcg tgatcccacc tcaagactac gagttcctgt ttgaggtggg ggtgtccaac     2160

gtgttcggcc ccgggaccag aattcccaag gccgcggtcc aggtgctgga cgacatcgaa     2220

aaatgcctgg agaaaaaaca gcagagcgtg                                      2250


<210>  188
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  188
atgcttagag ccaaaaatca gctttttctt ctgtcccccc actacctccg gcaggtcaaa       60

gagtctagcg gatcacgtct aatccagcag aggctgctcc accagcagca gcccctccac      120

cctgagtggg cagcgttagc gaaaaagcaa ctgaagggaa agaaccctga agatctgata      180

tggcatacac cagagggtat tagcatcaag cctctgtact caaagcgcga cactatggat      240

ctccccgagg agttacctgg agtgaagccc ttcacaagag gaccatatcc cactatgtac      300

acatttagac cttggactat acgtcagtac gccggtttta gcaccgtcga agaaagtaac      360

aaattttaca aagacaacat caaggctgga caacagggcc tgagtgttgc cttcgacctc      420

gctacacacc ggggctacga ctcagataat ccaagggtgc gcggcgatgt gggcatggcc      480

ggagtggcca tcgatacagt cgaggatacc aagattctct ttgacggcat tccacttgag      540

aagatgtccg tcagcatgac gatgaatggt gccgtgattc cagtgctcgc caattttata      600

gtgacgggcg aagaacaggg tgtgcctaag gaaaaactga ccggcacgat tcaaaacgat      660

atcctgaaag agttcatggt taggaatact tatatcttcc cacctgaacc aagcatgaag      720

ataatcgccg atatttttga atatactgcc aaacatatgc ctaagttcaa cagtatttca      780

atttccggat atcacatgca agaggctggc gcagatgcaa tattggagct agcatacacc      840

ttagccgacg gtttggaata tagtaggacc gggctccagg cagggctgac gatagacgag      900

ttcgcaccac ggctgtcatt cttttgggga attgggatga acttttacat ggagatcgca      960

aagatgcggg caggccgtcg gctctgggcc cacttgattg agaagatgtt ccaaccaaag     1020

aacagcaagt cgcttctcct gagggcacac tgccagacca gcggatggtc cttaactgag     1080

caagatccgt ataataatat cgtgaggaca gcgatcgagg ccatggccgc tgtcttcggt     1140

ggaactcaga gcctgcacac taattccttt gacgaggcac tgggtctgcc cacagtgaag     1200

agcgccagaa tcgcccgcaa tacgcagatc attatccaag aagagtccgg cattcccaag     1260

gtagcagacc catggggcgg ctcatacatg atggaatgtt tgacaaacga tgtgtatgat     1320

gccgctctta aactgatcaa cgaaattgaa gagatgggcg ggatggccaa ggcagtcgcc     1380

gagggcatcc ccaagctgag gattgaggaa tgcgcagcca gaagacaggc ccgtatcgat     1440

tcaggaagcg aagtgatagt gggcgtcaat aaatatcagc tggagaagga ggacgccgtc     1500

gaagtgctcg ctatagacaa taccagcgtt aggaatagac agatcgaaaa gcttaagaaa     1560

attaaatcgt ccagggacca ggcattagcc gaacgatgcc tggcggccct gactgaatgc     1620

gctgcatccg gcgatggcaa tatcctcgca ctcgcggtgg atgcctcacg ggccaggtgt     1680

accgtgggag agatcacgga cgctcttaag aaagtgtttg gcgagcacaa agcgaacgat     1740

cgcatggtat ccggggctta tcgccaggaa ttcggagaaa gtaaggagat caccagcgct     1800

attaaaagag tgcacaagtt tatggagcgt gaaggtcgca ggcctagact gttagtggcc     1860

aaaatggggc aggatgggca cgatcgtggc gcgaaagtta ttgccaccgg tttcgcagac     1920

cttggcttcg atgttgacat tgggcccctt tttcagaccc ctcgggaggt tgcccaacag     1980

gctgtcgatg cggacgtgca cgcggttggc gtgtcaaccc tggctgccgg gcacaaaacg     2040

ctggttccag aactgatcaa agagctcaat tctctaggta ggcccgacat cctggtgatg     2100

tgtggcgggg tgattcctcc tcaggattac gaattcctct ttgaggtggg cgtgtcaaac     2160

gtctttggcc caggcacacg aatcccaaaa gccgccgtac aagtattaga tgatatcgag     2220

aaatgcctcg aaaaaaaaca acagtccgtc                                      2250


<210>  189
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  189
atgcttcgcg cgaagaatca actgttcctc ctgagtccac attacctgag acaggtgaag       60

gagtctagcg gcagcagact gatacagcaa aggcttctgc atcagcaaca gccacttcat      120

ccagaatggg ccgccctagc aaagaaacaa ttgaaaggca agaatcctga agatctcatc      180

tggcacactc ctgagggcat cagtatcaaa ccgctctact caaaaaggga tactatggat      240

ttacctgaag aactgcccgg agtgaaacca tttactaggg gcccatatcc aaccatgtat      300

acatttcgtc catggactat caggcaatac gccggcttct ctacagtgga ggagtcaaat      360

aagttttata aggataatat taaggcaggg cagcagggct tgtctgtggc attcgatctg      420

gcaacgcacc ggggatatga tagtgataac cctagggtga gaggagacgt gggtatggct      480

ggggtggcta tcgacaccgt agaggacacc aaaattctgt ttgatggaat cccattagag      540

aagatgagcg ttagcatgac aatgaatggg gcagtgatcc ccgtgctggc aaattttatc      600

gtaaccggcg aagagcaggg cgtgcccaaa gaaaagttaa cgggtactat tcagaacgat      660

atcctgaagg aatttatggt cagaaacact tatattttcc ctccagagcc aagcatgaag      720

attattgccg atatcttcga gtacaccgcc aagcacatgc caaaattcaa cagcatctcc      780

atcagtggct accacatgca ggaagctggc gctgacgcca tcctggaatt ggcctatacg      840

ctagcggacg gattggaata tagtaggact ggacttcaag ccggcctcac aattgacgaa      900

ttcgcgccca gactgagttt tttctgggga attggcatga atttctacat ggagatcgct      960

aagatgcgag ccggccgacg gctctgggct caccttatcg aaaaaatgtt ccagcccaag     1020

aactctaagt ccttactgct gagggcccac tgccagactt cgggatggtc cctgacagaa     1080

caggacccat acaacaacat tgtcagaaca gctatcgagg caatggccgc cgtgttcggt     1140

gggacacagt cactccacac aaactctttc gacgaggctc ttggactgcc gacagtgaag     1200

agtgccagga tagccagaaa tacacagatt attatccagg aagagtctgg gatacctaag     1260

gttgcagatc cctggggggg gtcttatatg atggaatgcc tcaccaacga cgtctacgat     1320

gcagcattga agcttatcaa tgaaatcgaa gaaatgggtg gaatggctaa ggctgtagcc     1380

gaaggaattc ctaagctcag aatcgaagaa tgcgcagctc ggcgccaggc ccggatagac     1440

tctggctctg aagtgattgt aggggtcaac aagtaccagc tagagaagga ggacgccgtc     1500

gaggtattgg caattgacaa caccagcgtc cggaatagac agatcgaaaa actcaaaaag     1560

atcaaatcct ctagggacca agctctggca gagcgatgtc tcgctgccct gacagaatgt     1620

gcggccagtg gcgatggaaa catcctggct ctggccgtcg acgcaagtag agcgagatgc     1680

actgtggggg aaatcaccga tgcactgaag aaggtatttg gggaacataa agccaacgat     1740

aggatggttt caggtgcata tcgacaagag tttggagaaa gtaaggaaat caccagcgct     1800

atcaaacgcg tgcataagtt tatggagcgc gagggacgta gacctcgctt actggtggcg     1860

aagatgggac aggacggaca cgacagaggc gctaaagtga tcgccacagg attcgcggat     1920

ctcggcttcg acgtcgacat cggtccactg ttccagactc cgcgtgaagt tgcgcagcag     1980

gctgttgacg ctgatgtaca tgctgttggg gttagcacat tagcggcagg acataagacc     2040

cttgtgcccg agctgataaa agagctcaat tcccttggca gaccagacat tctggtgatg     2100

tgtggtggcg tcatcccacc tcaagattac gaatttttat ttgaggttgg ggtgtccaat     2160

gtctttgggc ccgggactcg cataccgaaa gctgccgtgc aggtgctcga cgatatcgag     2220

aagtgcctcg agaagaaaca gcaaagtgtg                                      2250


<210>  190
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  190
atgctgcgag ctaagaacca actttttctg ctttctcctc actatcttag gcaagtgaag       60

gaaagttcag gctcacgtct gatccaacag agactgttgc accagcagca gcctttgcac      120

ccggagtggg ctgcactggc aaagaaacag ctgaaaggga aaaacccaga ggacctaatt      180

tggcacactc ccgaaggaat cagcatcaag cctctctact ccaaaaggga cacaatggac      240

ttgcccgaag aacttcccgg cgtgaaacct ttcaccagag gcccttaccc tacaatgtac      300

actttcagac cctggacgat caggcagtat gcaggcttct ccactgttga agaaagcaac      360

aaattctata aggacaacat aaaagccgga cagcaggggc tgtccgtggc cttcgatctg      420

gccacgcatc ggggttatga cagcgataac cctagagtta ggggagatgt tggaatggcc      480

ggtgtggcca ttgacactgt ggaagataca aagatactgt ttgatgggat ccccctcgaa      540

aagatgtcgg tctcaatgac aatgaacggg gcagttattc cagtgcttgc aaacttcatt      600

gtgactggag aagagcaggg ggtccccaaa gagaaactga caggaaccat acagaacgac      660

attctgaaag agttcatggt ccggaatacc tatatttttc cgccagagcc gtccatgaaa      720

atcattgcag atatttttga atacactgcc aagcacatgc ctaaatttaa tagcatcagc      780

atcagtggct accacatgca ggaagcggga gctgatgcca ttctagaact cgcgtacacc      840

ctcgcagatg ggttggaata tagcagaaca ggcctccagg cggggctcac aattgatgaa      900

tttgcaccca ggctgtcgtt tttctgggga atcggtatga acttctatat ggaaattgca      960

aagatgcgcg ctggcagaag gctgtgggca cacctcatcg aaaaaatgtt ccagcctaag     1020

aacagcaaga gcctgctgct gcgggcgcac tgccagacct ctggctggag tctgacagag     1080

caggatcctt ataacaatat cgtgcgtacc gccattgagg ctatggccgc tgttttcggt     1140

ggcacgcagt ccctccacac aaacagcttt gatgaggctc tgggccttcc tactgtcaaa     1200

agcgcaagaa tcgcacgcaa tacacagata ataatccagg aagagtcagg cattccaaag     1260

gtggccgacc catggggggg cagctatatg atggagtgcc ttacaaatga tgtgtacgac     1320

gcggcactga agttaattaa tgagattgaa gaaatggggg ggatggctaa ggcagtggcg     1380

gagggtatac ccaagctgag aatcgaagag tgtgccgctc gcagacaagc taggatcgac     1440

agcgggagtg aagtcatcgt cggagtaaac aaatatcagc ttgagaagga agatgctgtt     1500

gaggtgttgg cgatcgacaa caccagcgtg cggaatagac agatcgaaaa gctgaagaag     1560

attaagtcta gccgcgacca ggctctggca gagcgctgtc tggccgcgct aactgagtgt     1620

gcagccagcg gggacggaaa cattctcgcc ctggctgtcg acgcaagccg cgcacggtgc     1680

acagtagggg aaattaccga cgctctcaag aaagtcttcg gtgagcacaa ggcaaatgac     1740

cggatggtaa gcggagctta taggcaggaa ttcggagaaa gcaaggaaat cacttctgct     1800

attaagcgtg tgcacaaatt tatggaacgc gaagggagac gcccacgctt gcttgtggcc     1860

aagatgggac aggacggcca cgatcggggt gctaaagtca ttgcgacagg gtttgctgat     1920

ctcggatttg atgtggatat aggcccactt ttccagaccc cacgagaggt cgctcagcag     1980

gcagtggacg ccgatgtgca cgctgtgggc gtgtccaccc tggccgccgg acacaaaact     2040

cttgtccccg agcttattaa agagctgaat agtcttgggc ggcccgatat tcttgttatg     2100

tgtggagggg ttattcctcc tcaggactat gagtttctgt tcgaagtcgg cgtgtccaat     2160

gtatttggcc ccggaacacg tataccaaaa gcggctgtac aggtgttgga tgacatcgaa     2220

aaatgtctgg aaaagaaaca gcagagtgtg                                      2250


<210>  191
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  191
atgctacggg ccaagaatca attatttttg ctttccccac attacctccg ccaggtcaaa       60

gaaagctccg gcagcagact tattcagcaa aggctcctgc accagcagca gccccttcac      120

cccgaatggg cagcgctagc caagaaacag ctaaagggga agaatccaga agatctgata      180

tggcacaccc cagaggggat cagtatcaag cctctatact ccaaaaggga cactatggac      240

ctgcctgagg aattaccagg cgtgaaaccc tttacccggg gcccttaccc cacgatgtac      300

acttttaggc cttggactat ccgccagtac gcgggatttt ctacagtcga agaaagcaac      360

aaattctaca aggataatat caaggccgga cagcaaggct tgagcgttgc cttcgattta      420

gcaactcaca ggggctatga cagcgacaat cctagggtta ggggggacgt gggcatggca      480

ggagtggcca tcgacacagt ggaagacacc aaaattttgt tcgatggaat tcctctggaa      540

aaaatgtccg tgagtatgac tatgaatggg gctgttatcc ctgtcctggc aaatttcatt      600

gtcaccgggg aggaacaggg cgtacccaag gagaagctga caggtaccat ccaaaacgat      660

atcctgaagg agttcatggt aaggaacacc tacatcttcc ctcccgaacc ttccatgaag      720

ataatcgccg atatctttga atacaccgcc aagcatatgc ctaaattcaa ttctatttcc      780

atctccgggt accacatgca agaagcggga gccgatgcta ttttggagct ggcatataca      840

ttagcagacg gcctcgaata ctcacgaaca ggtttgcagg caggtctgac tatcgacgag      900

ttcgccccca ggctttcatt tttttggggc atcggcatga acttctacat ggagatcgct      960

aagatgaggg caggacggag actatgggcc cacctgatcg agaagatgtt ccagcccaag     1020

aattctaaaa gcctactcct gcgggctcac tgtcagactt ccggttggtc tctgactgag     1080

caggacccgt ataataatat cgtaagaaca gcaatcgaag ctatggcagc tgttttcggc     1140

ggtacacagt ctctgcacac caacagcttt gacgaggcgc tggggcttcc aaccgtaaaa     1200

agtgcacgga tcgcgcggaa cacacagatc attatccagg aagaatccgg cattccgaag     1260

gtggccgatc cttggggtgg cagttatatg atggagtgcc taacgaatga tgtttacgac     1320

gctgccctta agctcattaa tgaaatcgag gagatgggag gaatggctaa agctgtggca     1380

gaggggatcc caaagctccg aatcgaagaa tgtgccgctc ggagacaggc aaggatcgat     1440

tccggaagcg aagtcattgt gggggtcaac aagtatcagt tagagaagga agatgctgtg     1500

gaggtactgg ctattgacaa tacgtctgtg aggaatcggc aaatcgagaa actgaagaag     1560

atcaaatcct ctcgagacca agccctggcc gaaagatgcc tagccgcctt aaccgaatgc     1620

gcggccagtg gggatggcaa tattttagcc ctggctgtgg atgcatccag agccagatgc     1680

acagtgggtg agatcacgga cgcgctcaag aaggtgtttg gcgaacataa agccaatgat     1740

agaatggtca gcggggccta caggcaggag tttggcgaaa gcaaagagat taccagcgcc     1800

atcaaacgcg tccacaagtt tatggagagg gaagggcgac ggcctcgcct cttagtggcc     1860

aaaatgggcc aggacggtca cgacagaggc gctaaggtga tcgcgacagg ctttgcggac     1920

ctaggctttg acgtggatat tggtccactg ttccagacac cccgtgaagt cgcacagcag     1980

gctgtggatg ctgatgtgca tgcagttggg gtttcgactc tcgccgcagg tcacaaaacc     2040

ctggtccccg aattaattaa ggaactgaat agcctgggaa gacccgatat cctggttatg     2100

tgcggcgggg ttattcctcc ccaggactac gaattccttt ttgaggttgg cgtctcaaat     2160

gtgttcggcc caggaacgag gattcccaaa gctgcagtcc aggtgcttga cgatatagag     2220

aagtgtctgg agaagaaaca acagtccgtg                                      2250


<210>  192
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  192
atgctacggg ctaagaacca gctcttccta ctttcccctc attacctcag acaagtaaaa       60

gaaagttcgg gatcccgcct gatccagcag cgcctgctgc accagcagca gcccctccat      120

cctgagtggg ccgccttggc taagaagcaa ctgaaaggga aaaacccaga ggatttgata      180

tggcatacgc ctgagggcat atctataaaa ccactgtact cgaaaagaga cactatggac      240

ttgcccgagg agctccccgg tgttaaacct ttcacccgag ggccataccc gaccatgtac      300

actttccgtc cctggaccat tcggcagtac gcagggttca gcacagtaga ggagtctaat      360

aagttctaca aggacaacat taaagccggt cagcaggggc tgagcgtagc cttcgaccta      420

gcaacgcacc ggggctatga ctctgataac cctagggtga gaggagacgt aggaatggct      480

ggcgtggcaa ttgacactgt ggaagataca aagatcttat ttgacggaat tccccttgaa      540

aagatgtctg tttctatgac catgaacggc gccgtgatac cagtactcgc aaatttcata      600

gttaccggag aagaacaagg agttcccaag gagaaactca cgggtacaat tcaaaatgac      660

attctgaaag aattcatggt taggaacact tacatcttcc cacccgaacc ctctatgaag      720

attattgctg atatattcga atacacagct aaacacatgc ctaaatttaa ttccatctcc      780

atcagtggct accatatgca ggaagcaggc gcagacgcca tcttggagct ggcttacact      840

ctcgctgacg ggctcgaata ttctcgtacg gggcttcagg cagggctcac cattgacgag      900

ttcgctccac gtctctcatt tttctggggc ataggcatga atttctacat ggagatcgct      960

aagatgaggg ccggcaggag gctctgggcc catctgatag agaaaatgtt ccagcccaaa     1020

aactccaaat cactgcttct gagagctcat tgccagacta gcggctggag cctgaccgaa     1080

caagacccct acaataatat tgtaagaact gcgatcgaag ccatggccgc cgtgtttggc     1140

ggcactcagt ccttgcacac caattcattc gatgaagcct taggcctgcc aactgtgaag     1200

tcagcccgca tcgctcggaa tacgcagatc atcattcagg aggagagcgg aatccccaaa     1260

gtcgccgatc cctggggagg ctcctacatg atggaatgtc ttacgaatga cgtctatgat     1320

gcggccctaa agctaataaa cgagattgaa gagatgggcg ggatggccaa ggccgtggct     1380

gaaggaattc caaagctcag gatcgaagaa tgtgccgccc gccgccaagc tagaattgat     1440

tccggtagtg aggttattgt aggagtcaac aagtatcagc tggaaaagga ggatgccgta     1500

gaagtgcttg ccatagataa tacgtccgtg cgaaatcgcc aaatcgaaaa gttgaagaaa     1560

attaagagca gtcgcgacca ggccctcgcc gagaggtgcc tcgctgctct cacggagtgc     1620

gccgcttctg gcgacggcaa tatcctcgcc ctggctgtgg acgcatccag ggctcgttgt     1680

accgtgggtg aaataacgga tgccctgaag aaggtgtttg gtgagcacaa agccaacgac     1740

cgcatggtga gtggcgccta cagacaggag tttggggaat ctaaagagat cacctctgct     1800

ataaaaagag tgcataaatt tatggaaagg gaaggtagga ggcccaggct tctggtggcc     1860

aaaatggggc aggacgggca cgaccgcggt gccaaagtca ttgccacagg ctttgccgac     1920

ttgggattcg acgtggatat tgggccactg tttcagactc cacgtgaagt tgcgcagcag     1980

gccgtcgacg ccgatgtgca cgcagtggga gtttccaccc tggcagcagg gcataaaacc     2040

ctcgtgcctg aactcattaa ggaactaaac agtctgggca gaccagatat cctggtaatg     2100

tgtggaggcg tgattccccc ccaagattac gagttcttgt tcgaggtggg cgtcagtaac     2160

gtgttcgggc ctggtacgcg aattcccaaa gctgcagtgc aagtgctcga cgatattgaa     2220

aaatgcctag agaagaagca gcagagcgtg                                      2250


<210>  193
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  193
atgttgcgtg ccaagaatca gctcttcctg ctgtcccctc actacctccg gcaggtcaag       60

gagtcttcag gtagtagact catccagcag agattgctgc accagcaaca acctttacac      120

cccgaatggg cagcgctagc aaagaaacaa ctcaagggaa aaaaccctga ggacttaatt      180

tggcatacgc ccgaggggat ttcgatcaaa cctttataca gcaaacgcga tactatggac      240

ttgcctgagg aactgcccgg cgtgaagccc tttaccaggg gtccctaccc cactatgtat      300

acatttcggc cttggactat tcggcagtac gctggattta gcaccgtcga ggaaagtaac      360

aagttttaca aggacaacat caaggcaggt cagcagggac tcagcgtcgc attcgactta      420

gcaactcacc gcggttatga tagtgataat cctcgagtgc gaggcgatgt gggaatggcg      480

ggagtggcta tcgacaccgt cgaggacacc aagatcctgt ttgacggtat cccactggag      540

aagatgtccg ttagcatgac tatgaacggc gccgtcattc cagtgctggc aaattttatc      600

gttactggag aggagcaggg ggtgccgaaa gagaagttga ccggtactat tcaaaatgac      660

atcttaaagg agttcatggt ccggaataca tacatctttc cccccgagcc atcgatgaag      720

atcatcgccg acatttttga gtacacggca aaacacatgc ctaagtttaa cagtatatcc      780

atttccggtt atcatatgca ggaggccggc gctgacgcaa tcctggaatt ggcctataca      840

ttagcagatg gcctggaata tagtcggacc ggcttgcaag cgggcctaac catcgacgag      900

tttgctccaa ggctcagttt cttttggggg attgggatga acttttatat ggaaattgcc      960

aagatgcgag ctggtagacg gctgtgggct catttaattg agaagatgtt tcagcccaag     1020

aattctaagt cccttctcct gcgggcccac tgtcagacca gtgggtggtc tctcacggaa     1080

caggaccctt ataataacat tgttcggaca gcgattgaag ccatggctgc agtttttggc     1140

ggaactcagt ctctgcacac caattccttc gatgaagctc tcggactccc gaccgtcaag     1200

tctgcccgga tcgcccgcaa cacgcaaatc atcattcagg aagagagcgg aatcccgaag     1260

gtcgccgacc cgtggggcgg aagttacatg atggaatgtc tgaccaacga tgtgtatgat     1320

gcggctctta aactgatcaa cgaaatcgag gagatgggcg gcatggctaa ggccgtcgca     1380

gagggcattc ctaagctgcg tatcgaggaa tgtgctgcta gacgccaggc acggatcgac     1440

agcggctccg aggtgatagt gggtgtgaac aaatatcaac tcgagaagga ggacgccgtt     1500

gaagtactgg ctatcgacaa cacaagcgta cgtaatagac agatcgagaa gctgaagaag     1560

atcaagtcta gtcgcgacca ggccctggct gaaagatgtc tagctgccct aacagagtgc     1620

gctgcatccg gcgatggcaa tatacttgcc ttggccgttg atgctagtag ggccagatgt     1680

actgtgggtg agattactga cgcccttaaa aaagtctttg gggagcacaa agcaaacgac     1740

cgtatggtat caggtgctta ccggcaagaa tttggggaaa gcaaagaaat tacctctgct     1800

atcaagaggg tgcacaagtt catggagcgt gaaggaagac gtccccgcct gcttgtcgct     1860

aaaatgggcc aggatggtca tgatagaggc gccaaagtga ttgcgaccgg ctttgccgat     1920

ttggggttcg atgtggacat aggcccacta ttccagaccc ctagagaagt cgcccagcag     1980

gctgtcgatg ctgacgtcca cgctgtgggg gtgagcaccc ttgccgccgg acataaaact     2040

ctggtgcctg agcttattaa agaactcaat agcctgggcc gccctgatat cctagtcatg     2100

tgtggcggag ttatacctcc gcaggactac gagttcctgt ttgaggtcgg ggtgtctaac     2160

gtctttgggc cgggaacccg catcccaaaa gctgcggtgc aggttctgga cgacattgag     2220

aaatgcctgg agaagaaaca acagtcggtt                                      2250


<210>  194
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  194
atgcttcggg cgaagaatca gctttttcta ctctcccctc attacctccg acaggtgaaa       60

gagagcagtg gatcaagact cattcaacaa cgtctgcttc atcagcagca gcctttacat      120

cccgaatggg ctgctctggc caagaagcag ctgaaaggaa aaaatccgga ggacttaatc      180

tggcacacac ccgagggaat ctcaattaag cccctgtatt ctaagcgaga cactatggat      240

ctccctgaag agctgccagg ggtgaaacct tttacacgcg gaccctaccc cacaatgtac      300

acatttcggc catggacgat tcggcaatac gcagggttta gcacggtgga agaatcaaat      360

aagttctaca aggacaatat taaggcaggc caacagggcc ttagcgtcgc tttcgatctc      420

gccacccaca gagggtacga ttcagacaat cctagggtca ggggagatgt agggatggcc      480

ggagttgcga tagacaccgt cgaggacacc aagatcctgt ttgatgggat cccgctggaa      540

aagatgagcg tgtctatgac aatgaatgga gctgtgattc ctgtgttggc caattttatt      600

gtgacaggcg aggagcaggg agtgcctaag gagaagctga ctggtacgat ccagaacgat      660

attctcaaag aatttatggt gcggaacacg tacattttcc cacccgaacc tagcatgaaa      720

atcatcgccg atatattcga gtatacagca aaacatatgc ccaaattcaa ttccatatct      780

atcagcggtt atcacatgca ggaggcgggt gccgacgcaa tcctggagct ggcttacacc      840

ttggctgacg gcctcgaata tagcaggaca ggccttcaag cagggctcac gattgatgag      900

ttcgcgcctc gattgtcctt cttctggggg attggcatga atttttatat ggaaattgca      960

aagatgcggg caggacgacg actctgggca cacctaatag agaaaatgtt tcaacctaaa     1020

aatagcaaga gcctgctgtt acgcgcccat tgccagacta gcgggtggtc cctgactgaa     1080

caagacccgt ataacaacat agtgagaact gcaatcgaag ccatggccgc cgtgttcgga     1140

gggacccaga gtctgcacac gaatagtttt gacgaggccc tgggcctgcc gaccgttaaa     1200

tccgcgcgga tagccaggaa tacccagatc atcattcaag aagaatctgg gatccctaaa     1260

gtcgccgatc cctggggggg cagttacatg atggagtgcc tcactaatga cgtgtacgat     1320

gccgcattga agctgattaa cgagatcgaa gaaatgggcg ggatggccaa ggccgtagca     1380

gaaggcatcc ccaaattgcg gattgaagaa tgtgctgcgc gtagacaggc gcgtatcgat     1440

tctggatcag aagtaatcgt gggggtgaac aagtaccagc tcgagaaaga agacgctgtc     1500

gaagtcctgg ctatcgacaa tacttcagtc aggaaccggc agatcgagaa gctgaaaaag     1560

attaaatcca gtcgcgacca agccctggcg gagcggtgtc ttgctgcact gacggagtgc     1620

gctgcgagcg gtgatggcaa tatcctggcc ctggcagtgg atgctagtcg cgccaggtgc     1680

acagtggggg agattaccga cgctctcaaa aaggtcttcg gtgaacacaa agccaacgac     1740

agaatggtga gcggcgctta ccggcaggaa ttcggtgagt ctaaagagat aactagcgct     1800

atcaaacgcg tccacaaatt catggagcga gagggcagaa gacctaggct gctggtggcg     1860

aaaatgggtc aagacggaca cgataggggg gctaaggtca tagcaaccgg tttcgctgat     1920

cttggatttg atgttgacat aggtcctctt ttccaaaccc cgcgtgaggt ggctcagcag     1980

gctgtggatg cggatgtcca tgctgttggg gtctcaacac tggccgctgg ccacaaaaca     2040

cttgttcctg aactgataaa ggagctgaac agcctgggtc gtccagatat tctggttatg     2100

tgcgggggcg ttatccctcc ccaagactat gagttcctgt tcgaggtcgg cgtaagtaat     2160

gtgtttgggc ccgggacccg tatccctaaa gccgcagtgc aagtgcttga tgacattgag     2220

aagtgcttag agaagaaaca gcaatcggtg                                      2250


<210>  195
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  195
atgctgagag ccaaaaacca gctgttcctc ctcagcccgc actacctaag gcaggtaaag       60

gagagcagcg gatcaagact catccagcag aggctgctgc accagcagca accgctgcac      120

cccgagtggg ccgcactcgc caagaagcag ctgaaaggca agaacccgga ggacctaatc      180

tggcacaccc ccgaagggat cagcatcaag ccgctatact ccaaaagaga cacaatggac      240

ctacccgagg agctccccgg agtgaaacca ttcacccgcg ggccctaccc cacgatgtac      300

acgttccggc cctggaccat caggcaatac gccggcttct caaccgtgga ggagagtaac      360

aaattctaca aagacaacat caaagcggga cagcagggcc tctcagtggc cttcgacctc      420

gcaacacacc gcggctacga ctcagacaac cccagggtgc gcggggacgt cggaatggcc      480

ggagtcgcca tcgacacagt cgaggacacc aagatcctgt tcgacgggat ccccctggag      540

aaaatgagcg tgagcatgac catgaacggg gccgtgatac cagtgctggc caacttcatc      600

gtaacaggag aggagcaggg ggtgcccaaa gagaagctca cagggacaat ccagaacgac      660

atcctgaagg agttcatggt acgaaacacc tacatcttcc cccccgagcc cagtatgaag      720

ataatcgcgg acatattcga gtacaccgcc aagcacatgc cgaagttcaa ctcgatcagc      780

atctcaggct accacatgca agaggcaggg gcggacgcaa tcctggaact ggcctacaca      840

ctagccgacg ggctggagta cagccgaacc gggctgcagg cgggcctcac catagacgaa      900

ttcgccccac ggctgagctt cttctggggg atcgggatga acttctacat ggaaatcgcc      960

aagatgagag caggcaggcg actgtgggcc cacctaatcg aaaagatgtt ccaaccaaag     1020

aactccaaaa gcctgctcct ccgggcacac tgccaaacaa gtggatggag tctgaccgaa     1080

caggacccat acaacaacat cgtgcggaca gccatagagg ccatggccgc ggtgttcggg     1140

ggcacccaga gcctccacac caacagtttc gacgaagccc tggggctacc aaccgtcaaa     1200

tcggcccgga tcgcaagaaa cacacagatc atcatccagg aggagtcggg gatcccaaaa     1260

gtggcggacc catggggcgg gagctacatg atggaatgcc tgaccaacga cgtctacgac     1320

gccgccctaa aactgatcaa cgaaatagaa gaaatgggcg ggatggccaa ggccgtggcc     1380

gagggcatcc cgaagctccg catcgaggag tgcgcagcgc gacggcaggc gaggatcgac     1440

tcaggaagcg aggtcatagt aggcgtcaac aaataccagc tcgaaaaaga ggacgcagtg     1500

gaagtgctgg caatcgacaa cacctccgtc cgcaacaggc agatcgagaa actcaaaaag     1560

atcaagagct cacgggacca ggccctcgcc gagagatgcc tcgcggccct aaccgaatgc     1620

gcagccagtg gcgacggcaa catcctggcc ctagcagtcg acgccagcag ggccaggtgc     1680

accgtggggg aaatcaccga cgcgctgaag aaggtgttcg gagagcacaa ggccaacgac     1740

cgcatggtga gcggggccta caggcaggag ttcggcgaaa gcaaggagat caccagtgca     1800

ataaagaggg tccacaagtt catggaacga gaaggccgcc ggccaagact gctggtggcg     1860

aaaatgggcc aggacgggca cgaccgaggc gcaaaggtaa tcgcaacggg gttcgccgac     1920

ctggggttcg acgtcgacat cggacccctg ttccaaaccc ccagggaagt ggcccagcag     1980

gcagtggacg ccgacgtgca cgccgtgggc gtatcgaccc tggccgcggg ccacaaaacg     2040

ctggtcccgg agctcatcaa ggagctgaac agtctgggcc gcccagacat cctggtcatg     2100

tgcggcgggg tgataccccc gcaggactac gagttcctat tcgaggtcgg agtctcgaac     2160

gtgttcgggc ccggcacacg catcccaaaa gccgcagtcc aggtcctgga cgacatcgaa     2220

aagtgcctgg aaaagaaaca gcagtcagtc                                      2250


<210>  196
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  196
atgcttcggg caaaaaatca actcttcctg cttagtccac actacctacg acaggtaaaa       60

gagagctctg gttcccggtt aatccagcag agactgctcc atcagcaaca gcccctgcac      120

cccgaatggg cggctctcgc taagaagcaa ttaaagggca agaacccaga agacctgatt      180

tggcatacac cggaaggaat cagtatcaaa cccctctata gcaaaagaga tacgatggat      240

ctccccgagg aactgcccgg agtgaagccc ttcacgcgcg gtccataccc aactatgtat      300

acgtttcggc cctggacgat ccggcagtac gccggctttt ctaccgtcga ggagtctaat      360

aaattttaca aggacaatat caaggctggc caacagggct tgtcggtagc ctttgatctg      420

gccactcacc gtggatatga cagcgataat ccacgggtgc ggggggacgt cggtatggcc      480

ggtgtagcca tcgacaccgt agaagatacc aaaatcctct ttgatgggat ccccctcgag      540

aagatgtccg tgtcaatgac catgaacggt gctgtgatcc ctgtgctcgc caacttcata      600

gttaccgggg aagagcaggg ggtgcctaag gaaaagttaa ccgggacaat ccaaaatgac      660

atcctcaagg agtttatggt gcggaatact tatatattcc cacccgagcc ttcaatgaag      720

atcatcgctg atatcttcga gtacactgct aaacacatgc ccaagtttaa ttctattagt      780

atctcagggt accacatgca ggaggctggt gcagacgcca ttctggagtt ggcttacaca      840

ctggcggacg gtctcgagta ttctaggacg ggactccagg ccggacttac catcgacgag      900

tttgccccta ggctgtcatt cttttggggt atcgggatga atttttacat ggaaatcgct      960

aaaatgcggg ccgggcgccg gttatgggcc caccttattg agaaaatgtt tcagcccaaa     1020

aattctaagt ctctgctcct aagggcacat tgccaaactt cgggctggtc gcttaccgaa     1080

caggacccat acaacaacat tgtccgcacc gcaatcgagg ccatggctgc tgtgtttggg     1140

ggtactcagt ctctacacac caactccttc gatgaagcac tcggtctgcc gactgtgaaa     1200

agcgccagaa tcgcccggaa tacccaaata ataatccagg aggagtccgg gattcctaaa     1260

gtcgcagatc cttggggggg ctcttatatg atggagtgcc tgaccaatga cgtgtacgac     1320

gccgccctga agctaatcaa tgagatcgag gaaatgggag ggatggccaa agcagtggct     1380

gagggaattc ctaagctgag gattgaagag tgtgcagctc ggcgacaagc gcggatcgac     1440

agtggcagcg aggtcatcgt cggagtgaac aagtatcagt tagaaaaaga ggatgctgtg     1500

gaggtgcttg ctattgataa cacatcggtc cgcaatagac aaatcgagaa gctgaagaaa     1560

attaagagca gtcgcgacca ggcattggcc gagaggtgcc tcgccgccct gacagagtgt     1620

gccgcaagtg gagatggaaa catacttgct ctggccgttg atgcttccag agcccgctgc     1680

actgtaggag agattaccga tgcgttgaag aaggtgtttg gagaacataa agccaatgac     1740

cgaatggtgt caggagctta ccgccaggaa ttcggggaga gtaaagaaat aacaagcgca     1800

atcaagcgcg tgcacaaatt catggaaaga gaggggcgga gacctcgact attggtggcg     1860

aagatgggcc aagacgggca cgatcggggg gccaaagtga ttgctacggg attcgctgac     1920

cttggcttcg atgtggatat tggccccttg ttccaaacgc caagagaggt tgcccaacag     1980

gccgtggacg ccgacgtgca cgcagtgggc gtgtccaccc tggccgcagg ccataagaca     2040

ctcgttccgg aactaattaa agaattgaat tccctgggca gacccgacat actggtaatg     2100

tgtggcggag ttatcccccc gcaggactac gagttcttgt ttgaagtggg tgtgtccaat     2160

gtgttcgggc ctggtacccg aatcccgaaa gcggccgtac aggttctgga cgatatcgaa     2220

aaatgcttgg aaaaaaagca acagagcgta                                      2250


<210>  197
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  197
atgctccggg ccaaaaacca gctgtttttg ctgagccccc actacctgcg gcaagtcaag       60

gaatcttcag gttctcgcct gatacagcaa cgtctgctgc accaacagca gcccctgcat      120

ccagagtggg cagccctggc aaagaaacag ctgaagggaa aaaatcccga ggatcttatc      180

tggcatacac cagaagggat ctcgatcaaa ccactgtaca gtaagcggga taccatggac      240

ttaccggagg agctgcccgg tgtcaagcca tttactcgag gcccgtatcc caccatgtat      300

acttttcggc catggacaat acgtcagtat gccggattta gcacagtgga agaaagtaac      360

aaattttaca aagataacat aaaggctggc cagcaaggcc tctccgtagc tttcgatctg      420

gctacgcata ggggttatga tagtgacaat cctagggtgc ggggggatgt cggtatggct      480

ggcgtggcaa ttgacaccgt tgaggacacc aagatcctct ttgatgggat tcccttggaa      540

aaaatgagtg ttagcatgac aatgaatgga gctgttatcc ccgtgcttgc caattttata      600

gtcaccgggg aggagcaagg ggttcctaaa gagaagctaa cagggaccat tcagaatgac      660

atcttgaaag aatttatggt gaggaataca tacatcttcc ccccagaacc gtccatgaag      720

atcatcgccg atatcttcga atatacagca aaacatatgc cgaaattcaa ttctatttcc      780

atcagcggct atcacatgca ggaggctgga gcagacgcca tcttggagtt ggcctacaca      840

ttggctgacg gccttgagta ctctaggaca ggcctgcagg caggtcttac aattgacgag      900

ttcgcccctc gccttagttt tttttggggg atcggcatga acttttatat ggagattgcc      960

aaaatgagag cgggaagaag gctttgggcc cacctaatcg agaagatgtt tcagcccaaa     1020

aattctaagt ctctgctgct gcgcgctcac tgtcagacca gtggctggtc cctaacggag     1080

caagatccat ataacaacat agttcgtact gccatagaag ccatggccgc agtattcgga     1140

ggaacgcaaa gcttgcacac caattcattc gacgaagctc taggcctgcc gacagtgaag     1200

tcagcccgga ttgctcgtaa cacgcagatc atcatccaag aagaatccgg aatcccaaaa     1260

gtggcggatc cttggggtgg atcctacatg atggagtgct tgaccaacga tgtgtatgac     1320

gctgccctga agctaatcaa tgagatagag gagatggggg ggatggccaa agccgtagca     1380

gaagggattc caaaactccg catcgaggag tgcgctgcga ggcgacaggc ccggatagat     1440

agtggatccg aggtcattgt gggagtcaac aagtaccagc tcgagaagga ggacgcagtg     1500

gaagtccttg ccatagacaa tacctctgtc cgaaatcggc agatcgaaaa actcaagaaa     1560

ataaaatctt caagggacca ggctctcgcc gagcgttgcc tcgcggcact gaccgagtgc     1620

gcagcaagcg gcgacgggaa catcctcgct cttgctgtgg atgcctcccg ggcccgatgc     1680

actgtcggag agatcactga cgcactgaaa aaggtttttg gggagcataa ggcgaacgac     1740

cgcatggtgt ccggggccta cagacaggag tttggtgaat ccaaagaaat tacaagcgca     1800

ataaaacggg tccacaagtt tatggagagg gagggtcgtc gccctaggct cttggtggct     1860

aagatggggc aggatgggca tgaccggggg gctaaggtga tcgctactgg gttcgcggac     1920

ttgggatttg acgtggacat tggacctctg ttccagaccc cacgcgaggt cgcgcagcaa     1980

gccgtggatg cggatgtcca cgctgtcggc gtgtccacac tggctgccgg ccataagact     2040

ttagtgcccg aattgatcaa ggagttgaac tcactcggaa ggcccgatat cctggtgatg     2100

tgcggcggtg tcatcccacc acaggactat gaatttctgt ttgaggtggg ggtctccaac     2160

gtattcgggc cgggaacaag aattccgaaa gcagcggtgc aagtgctcga cgatatcgaa     2220

aagtgtcttg aaaaaaagca gcagtcggtc                                      2250


<210>  198
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  198
atgttgcgcg caaagaacca gctatttctt ttaagtccac actatctgcg tcaggtgaag       60

gagagttctg ggagtagact tatccaacag agactcttac accagcaaca gccccttcat      120

ccagaatggg ctgcactggc taaaaagcag ctgaaaggaa aaaatccgga ggacctcatc      180

tggcacacac ctgaagggat aagcattaag ccactctaca gcaagaggga cacgatggat      240

ctcccagagg agcttccagg ggtaaaaccg tttacacgcg gaccctaccc aaccatgtac      300

acgttccgac catggacaat cagacaatac gccggtttta gcactgtgga ggagtcaaac      360

aagttctata aagataatat caaagccgga caacagggac tttccgtggc ctttgacctg      420

gccacacacc ggggctacga ctctgacaac ccaagagtcc ggggcgacgt tggcatggcc      480

ggtgtggcca tcgacactgt cgaggacacc aagatcctgt tcgatggcat tcccttggaa      540

aaaatgagcg tgtctatgac catgaacggg gcagtaatac ccgtccttgc aaacttcatc      600

gtgaccgggg aagagcaggg cgttcctaag gaaaaactga cggggacaat tcagaacgac      660

atcctgaagg aatttatggt gcgaaatacg tacatattcc cccctgagcc gtccatgaag      720

ataattgccg acattttcga atacactgca aagcacatgc ccaaatttaa ctccataagc      780

atcagtggct atcacatgca agaggccggg gcagatgcta tcttggaact tgcctacact      840

ctcgcagatg gattagagta ctccagaaca ggtctgcagg ctggcctgac aatcgacgaa      900

ttcgccccca gactatcttt tttttggggt atagggatga atttctatat ggagattgcc      960

aagatgagag ctggaagacg tctctgggcc cacctaatcg aaaaaatgtt ccagcccaag     1020

aatagcaaga gtctgctcct ccgcgctcac tgccagacat cgggctggtc tctgactgaa     1080

caggatcctt ataataacat cgtcaggact gccatcgagg ccatggccgc cgtgtttgga     1140

gggacccagt ccttgcacac taacagcttc gacgaggctt tgggtctgcc tacggttaag     1200

tccgcccgca tagctcggaa cactcagatc atcatccagg aggaatcagg aattcctaag     1260

gttgccgacc catggggcgg aagttatatg atggaatgtc tcacaaatga tgtttatgac     1320

gctgctctga agctgattaa tgagatagag gagatgggtg ggatggcaaa agctgtggct     1380

gagggaatcc ctaagctcag aatcgaggaa tgtgcagcca gacggcaggc aagaatcgat     1440

tccggctccg aagtgatagt gggggttaat aagtatcagc ttgagaagga ggatgcagtg     1500

gaggtgctgg cgatagacaa tacctcggta agaaataggc agatagaaaa actcaagaag     1560

atcaagtcat ctcgcgatca ggccctggcc gaacgttgcc tggcagcact caccgagtgt     1620

gccgcatcag gggacggaaa catcctcgca ttagcggtcg atgcaagtag agcgcggtgt     1680

acagtcggcg aaatcactga cgcgttgaaa aaggtcttcg gggagcataa ggctaacgac     1740

cgcatggtga gcggcgctta ccgccaagaa ttcggagagt ctaaagagat taccagcgcc     1800

attaaacggg ttcataaatt tatggaacgg gaaggacgac gccctcggtt gctggtggca     1860

aagatgggac aggacggcca cgacagaggc gcgaaagtca ttgctacagg tttcgcagac     1920

ctcgggttcg atgtggacat aggccctctt tttcagactc cacgtgaggt ggcacaacag     1980

gccgtcgatg cagacgtcca tgccgtaggg gtgtcaaccc tggctgctgg acacaagacc     2040

cttgtaccag agctgatcaa ggagttgaac agcttagggc gtcctgatat tctcgtgatg     2100

tgtgggggag tgatcccacc gcaagattac gagttcctgt tcgaggtggg cgtgagcaat     2160

gtgttcgggc ctggcaccag aataccgaag gcagcggtcc aggtcttgga cgacatcgag     2220

aagtgcctcg aaaaaaaaca gcaaagcgtg                                      2250


<210>  199
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  199
atgctgagag ccaaaaacca gctctttctg ttgtcccccc actatctgcg gcaagttaag       60

gagagttccg gctcacgcct gatacaacag agactgctcc atcagcaaca gccgctgcac      120

ccagaatggg cagccctggc caaaaaacaa cttaaaggta agaacccgga ggatttgatc      180

tggcacacac ccgaaggaat ttccatcaag cctctatatt ctaaaagaga tacgatggat      240

ctgccagagg agttaccggg ggtgaagccg tttacacgcg ggccctatcc tacgatgtac      300

acgttcaggc cctggaccat caggcagtac gcaggtttca gcacagttga ggagagcaac      360

aagttttaca aggacaatat taaggccggc cagcaaggcc tttcggtagc cttcgacctt      420

gcaacacata gggggtatga ttccgacaac cctagggtca ggggcgatgt tggaatggcc      480

ggagtcgcga tagacacagt ggaagacacg aagatcctgt ttgatgggat ccctctggag      540

aaaatgagtg tctccatgac catgaacggc gcggtgatcc ctgttctggc caatttcatt      600

gtgaccggtg aggaacaggg ggtccctaag gagaaattga cgggcactat tcagaacgac      660

atcctcaaag aatttatggt tcgcaacacc tacattttcc ctcccgagcc cagcatgaaa      720

attatcgcag atatctttga atatactgca aagcacatgc ctaagtttaa ttctatcagc      780

attagtggct accatatgca ggaggccgga gccgacgcca ttctcgagct ggcatatacc      840

ttagccgatg ggctagagta ttcgcgaaca ggtctgcagg caggacttac aatcgacgaa      900

tttgccccac gcttgagctt tttttggggt atcggcatga acttctacat ggagattgcg      960

aagatgcgag caggaaggag actgtgggcc cacctcattg agaagatgtt tcagcctaaa     1020

aactctaagt cattactcct gcgggctcat tgtcagacca gtggctggag ccttaccgag     1080

caggacccgt acaataatat tgttcgcaca gctattgagg cgatggccgc cgtgttcggg     1140

ggcacgcagt cccttcacac gaactcattc gatgaagcac tgggcctgcc caccgtcaag     1200

tctgctcgaa ttgcccggaa tacacagata attatacagg aggaatctgg catcccaaag     1260

gtggctgacc cgtggggggg tagctatatg atggaatgcc tgactaatga cgtgtacgat     1320

gctgcgttga aactgataaa tgagattgag gagatgggtg gcatggcaaa ggcggttgct     1380

gaggggatcc caaagctccg catcgaggag tgcgctgcca gaaggcaggc gcggattgat     1440

tccggctctg aggttatcgt cggggtgaac aagtatcaat tggaaaaaga agacgccgtg     1500

gaagttcttg ccatcgacaa cacaagtgtg agaaatcgac agatcgagaa gttgaagaag     1560

atcaaatcat cccgggacca ggcattggcc gaacgctgcc tggccgcttt gaccgaatgt     1620

gcggccagcg gggacgggaa catcctcgcc ctcgcagtcg atgctagcag agcccgctgc     1680

accgtaggcg agatcaccga tgctctcaag aaagtcttcg gggagcataa agccaacgat     1740

agaatggtct ctggtgcata tcggcaggaa tttggcgaaa gcaaagaaat aacgtctgcc     1800

atcaagcgcg tgcataagtt tatggaacgg gaaggacggc gcccgagact gctggtagct     1860

aagatgggac aagatggaca cgataggggg gcaaaggtta ttgcaacagg tttcgccgac     1920

ctcggatttg atgttgatat tggtccttta ttccagacac cacgcgaagt ggctcagcag     1980

gcagtagacg ccgacgtgca tgccgttggc gtttcaaccc tggctgctgg ccacaagacc     2040

ctcgtgcccg agctgataaa agaactcaac agcctgggga ggccagacat tctggtcatg     2100

tgcggaggag tgatccctcc tcaggactac gaatttttgt tcgaagtggg agtatcaaac     2160

gtctttggtc ctggcacccg catcccaaag gccgctgtcc aggtcctgga cgacattgaa     2220

aagtgtctgg aaaagaaaca acaatcagta                                      2250


<210>  200
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  200
atgctgaggg ctaagaatca gctctttctg ttgtccccac actatttacg gcaggtgaaa       60

gagagcagtg gttctaggct gatccagcag cggctcctgc accagcagca gccattgcat      120

cctgagtggg cggctctcgc caagaaacag ctgaagggaa agaacccaga ggatttgatt      180

tggcacactc ccgagggcat cagcatcaaa cccctgtatt cgaagcgcga cacaatggac      240

ctccccgaag aactaccagg agtgaagccc tttacgcggg gaccctatcc caccatgtat      300

accttccgcc cgtggacgat tcgccagtac gcaggtttct caaccgttga ggaatcaaac      360

aagttttata aagacaatat caaggctggc cagcagggac tctccgtggc atttgacctg      420

gcaacccacc gtgggtacga ttccgataac ccccgcgtac ggggtgatgt tgggatggcc      480

ggcgtcgcta ttgacactgt tgaagacacg aagattctct ttgacggaat cccgctggag      540

aagatgagcg tttcaatgac aatgaatgga gcagtgatcc ccgtcttggc caactttata      600

gtgacggggg aggagcaggg cgtgcctaag gagaaactga caggcacaat ccagaatgac      660

atcttaaaag agttcatggt taggaatacc tacatcttcc cccccgaacc ttcaatgaag      720

atcattgccg atatcttcga atacactgca aagcacatgc ccaagtttaa ctctatttcc      780

attagcggat atcacatgca ggaagccgga gcagacgcta tcctggaatt ggcgtacacc      840

ttagccgacg ggttggaata ttcccggaca gggctccagg cggggctgac aatagacgag      900

tttgcaccca ggctgtcctt cttctggggc ataggaatga atttctacat ggagatcgct      960

aagatgcgag ctgggagaag actctgggcc cacctcattg agaaaatgtt ccagcccaaa     1020

aacagcaaat ccctgcttct gagagctcac tgccaaacaa gtggctggag tctcaccgaa     1080

caagatccgt ataacaatat cgttaggaca gcaattgagg caatggcggc agtgttcggg     1140

ggaacacagt ccttgcacac gaatagtttt gacgaggcac tcggcctgcc cacggtcaag     1200

tcggcacgaa tagccaggaa cacacagatc atcatccagg aggaatctgg cattcccaaa     1260

gtagccgatc catggggcgg atcctacatg atggaatgtc ttacaaacga tgtatacgac     1320

gccgctctga agctcattaa cgaaatcgag gagatgggag gtatggccaa agctgtggcg     1380

gaaggaatcc caaagctccg aatcgaggaa tgcgccgccc ggcggcaagc caggatcgac     1440

tcaggatcag aagtcattgt cggtgtcaac aagtatcaac tggaaaaaga ggatgcagtc     1500

gaagtgctgg ccatcgataa tactagtgtc cggaatcgcc agattgaaaa actgaagaaa     1560

attaaatcct ctcgcgacca ggcattggct gagagatgcc tggcagcact tacagagtgt     1620

gccgccagtg gggatggaaa catccttgct ctggcagtgg atgcctcccg cgcccgttgc     1680

actgttggtg agatcacgga tgctctgaag aaggtgttcg gcgaacacaa ggcaaacgac     1740

agaatggtga gcggcgccta ccggcaggag ttcggggaaa gcaaagaaat cacctcagca     1800

attaagagag tgcacaaatt catggaaaga gaaggacgca ggcccagact tttggtggcg     1860

aagatgggac aagatggcca cgaccgtggt gctaaagtaa tcgcaacagg ttttgcagat     1920

ctgggcttcg atgtggatat tggaccgctc ttccagacgc cacgcgaggt cgctcagcaa     1980

gctgttgacg ctgacgttca tgccgtgggg gtctctacgc tggctgccgg ccataaaacc     2040

ctggtccctg agctgatcaa agagctgaat agtctcggtc ggcccgacat cctcgtcatg     2100

tgcggcggag ttataccccc tcaggactac gagtttcttt ttgaagtggg ggtctccaat     2160

gtcttcggcc cgggaactcg gattccaaag gctgccgttc aggtgctcga cgacatagaa     2220

aaatgtctgg agaaaaagca acaatcagta                                      2250


<210>  201
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  201
atgctgagag caaagaatca gctgtttttg ctgagcccgc actacctgcg gcaagtaaaa       60

gagtcttctg ggagcaggct aatacaacag cgccttctgc accaacaaca gcctctccat      120

ccagagtggg ccgctcttgc taaaaagcaa ctgaagggca agaacccaga ggatcttatt      180

tggcacaccc cggaggggat ttccatcaag cccctctact ccaaacggga caccatggac      240

ctccccgaag aacttcccgg cgtaaagcca tttacacgag gtccctatcc gacaatgtac      300

acatttcggc cgtggacaat ccgacagtac gctggcttta gcaccgtgga agaatcaaac      360

aaattctaca aagataatat caaagctggg caacaaggac tgtcagtcgc attcgacctt      420

gctacacatc gaggatacga ttccgataac ccgcgcgtca gaggtgacgt aggaatggca      480

ggggtggcga tcgacaccgt cgaggacaca aaaatattgt tcgatgggat tcccctggaa      540

aagatgtccg ttagcatgac aatgaatgga gcagttattc cggtgttggc aaatttcata      600

gtgacgggtg aggagcaggg tgtccctaaa gagaagctaa ctggcacaat tcagaatgat      660

atcctgaaag aattcatggt gcgcaatacc tatatctttc ctccagaacc ttctatgaag      720

attatagcag acatatttga gtacaccgca aaacacatgc ccaagttcaa ctcgatttct      780

atttctgggt accacatgca agaggccgga gccgacgcca tactggaact cgcctacact      840

ctcgcagatg gactcgagta ctcaaggaca ggcttgcagg ccgggctgac aatcgacgag      900

ttcgctccca gacttagctt tttctggggc atcggcatga acttttatat ggaaatcgcc      960

aaaatgaggg caggccgacg tctatgggcc catctgatcg agaagatgtt ccaaccaaag     1020

aattccaagt ccctactcct tagggcgcat tgccagacct ccggatggag cctgaccgaa     1080

caggatccat acaataacat tgttagaaca gccatcgaag caatggccgc agttttcggc     1140

ggaactcagt cccttcatac aaatagcttc gacgaggcac tgggtctgcc taccgtgaaa     1200

tctgccagaa tcgctcgtaa tacccagata ataatccagg aggaatcagg tatccctaag     1260

gtcgccgacc cctggggggg gtcttatatg atggaatgtc taaccaacga cgtctatgac     1320

gctgctctca aactcattaa tgaaattgaa gaaatgggcg gtatggccaa agctgtcgca     1380

gagggcattc ctaagctgcg catagaggaa tgcgcagcaa ggaggcaagc acggatcgat     1440

tccggatctg aggtaatcgt gggcgtcaac aagtatcagt tggagaagga ggacgccgtc     1500

gaggtcttgg caattgataa caccagcgtt cggaatcgtc agatcgaaaa actgaaaaag     1560

atcaagtctt ctcgagatca ggccttggca gagcgttgtc tggctgcttt aaccgagtgc     1620

gcagcctctg gagacggaaa tatcctggcc ctggccgtgg acgcctcccg ggcacgctgt     1680

acagtggggg aaattacaga tgctctgaag aaagtattcg gagagcacaa agcaaatgac     1740

cgaatggtct ccggcgccta taggcaggaa ttcggcgaat cgaaagaaat cacctcagcg     1800

attaagagag tccacaaatt catggagcgc gaaggaaggc ggccacgttt actcgtagcc     1860

aaaatggggc aggacggcca tgatcgggga gctaaagtaa tagcaaccgg tttcgcagac     1920

ctggggtttg acgtggacat tggtccattg tttcagaccc ccagggaggt tgctcagcag     1980

gctgtggacg cggacgtgca tgccgtggga gtgtcgaccc tggctgcagg acacaaaaca     2040

ctagtccccg aactcattaa agagctcaac tcactgggtc ggcccgatat actggttatg     2100

tgtggtgggg tgattccccc acaggactat gagttcttat tcgaggttgg tgttagtaat     2160

gtctttggac cagggaccag gattcccaag gcagcggtgc aagtgttaga cgacattgaa     2220

aaatgcctgg aaaagaagca gcagtcagtg                                      2250


<210>  202
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  202
atgctgcgcg caaagaatca acttttcctg ctgtccccac actacctccg tcaagtgaag       60

gagtcctccg gcagcaggct gatccagcaa cgactgttac accaacagca gcctctgcac      120

ccagaatggg ctgctttagc aaagaagcag ctgaaaggaa agaacccaga agacctaata      180

tggcacacgc ctgaaggtat ctccattaag cctctgtact caaaacggga cactatggat      240

ctccctgagg agctgccagg cgtcaaaccg tttactcgcg gtccttaccc tactatgtac      300

acattccggc catggaccat acgacagtat gctggattct ctaccgtgga agagagcaat      360

aagttctaca aggataatat taaggcaggc cagcagggac tgagcgtagc gtttgatctt      420

gccacacacc gtgggtatga ctctgataat ccacgagtaa gaggggacgt cggtatggcc      480

ggagttgcaa tcgatactgt agaggataca aaaattctct ttgatgggat accgctcgag      540

aagatgtccg taagcatgac tatgaacggt gccgtgatcc ccgtgctcgc taactttatc      600

gtcaccggcg aagaacaggg cgtgcccaag gagaaattga caggtacaat ccagaacgat      660

attctaaagg agttcatggt gcggaataca tacatttttc cacccgaacc ctctatgaaa      720

atcattgccg acatcttcga gtacaccgcc aagcatatgc ctaagttcaa ctctatttct      780

ataagcggct atcacatgca ggaagcaggt gccgacgcca ttctcgaact ggcttatacc      840

ttggcagatg gactggaata ttcaagaacc gggcttcagg ccggtctcac aattgacgaa      900

tttgcgcctc gactgagttt cttttgggga ataggtatga atttctatat ggaaatagcc      960

aagatgcgcg ccggcagaag gctttgggcc catttgatcg agaaaatgtt tcagccaaaa     1020

aacagcaaaa gtctgctctt acgcgcccac tgtcagacct ctggctggtc gttgacagaa     1080

caggatccct ataacaacat cgtacggact gctattgagg caatggcagc agtgtttggc     1140

ggaacccaga gcctgcatac caattcattt gacgaagctc tgggtctgcc aactgtgaaa     1200

tcagcccgca ttgcccgcaa cacccagatt ataatacagg aagaaagtgg cattcccaaa     1260

gtggcggatc cttggggagg aagctacatg atggagtgcc tgactaatga cgtatacgat     1320

gcggcgctga aactgatcaa tgaaatagaa gaaatggggg gaatggccaa ggccgtggcg     1380

gagggcatac ctaaactaag gatcgaggag tgtgcagcca gacgccaggc tcgcatcgac     1440

tccggaagtg aagttatagt tggcgtgaat aaatatcagt tagagaagga ggatgccgtg     1500

gaggtgctgg cgatcgataa taccagcgtc cgcaataggc agatagaaaa gttgaaaaag     1560

attaaatcgt cccgcgacca ggccctggcc gaacgctgtc tggccgcact cactgagtgt     1620

gccgcaagtg gagatggcaa tatcctcgct ctagcagtgg acgcctccag ggcaagatgc     1680

accgtgggag aaatcaccga tgccctgaag aaagtgttcg gagaacataa agccaatgat     1740

cgcatggtga gcggggcgta tagacaggaa tttggagaat ctaaggagat tacaagcgct     1800

atcaagaggg tgcacaaatt tatggaaagg gaagggaggc gccccaggct acttgtggcc     1860

aaaatggggc aggacggcca tgacaggggc gccaaggtga tagccactgg cttcgcggac     1920

ttggggtttg atgttgatat cggccccctc ttccaaacac cccgcgaggt ggcgcaacag     1980

gcagtggatg ccgatgttca cgcagtgggg gtgagtacac tcgccgcggg ccacaagacc     2040

ttagttcctg agctgataaa agagctcaat tccctcggga ggcctgatat cctggtgatg     2100

tgcggaggag tcattccccc acaagactac gagtttttat ttgaggtggg cgtttctaat     2160

gtcttcgggc ctggaacccg gatcccaaaa gcagccgtac aggtgctgga cgatattgaa     2220

aaatgccttg agaaaaagca gcagtccgtc                                      2250


<210>  203
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  203
atgctccgag cgaagaacca gctattcctg ctcagcccgc actacctgcg gcaggtgaag       60

gagtcaagcg gctcacgcct gatccagcag agactgctgc accaacagca acccctgcac      120

ccagagtggg cagccctggc caagaagcag ctcaagggga agaaccccga agacctgatc      180

tggcacacac cagaagggat atccataaaa ccactataca gcaaaaggga cacgatggac      240

ctcccagaag agctgccagg cgtgaagccc ttcacccgcg ggccataccc aaccatgtac      300

accttcagac catggacaat ccggcagtac gcggggttct caaccgtgga ggagtccaac      360

aaattctaca aggacaacat caaagcaggg cagcagggcc tgagtgtagc attcgacctg      420

gcaacgcaca ggggatacga ctccgacaac cccagggtgc ggggcgacgt gggcatggcc      480

ggggtcgcca tcgacacggt ggaagacaca aagatcctgt tcgacggcat ccccctggag      540

aaaatgtccg tgtcgatgac aatgaacggg gccgtgatcc ccgtgctagc aaacttcatc      600

gtcacagggg aggagcaggg ggtgccaaaa gaaaaactga caggcacaat ccagaacgac      660

atactcaagg agttcatggt caggaacacc tacatcttcc ccccagagcc atcgatgaaa      720

atcatcgccg acatcttcga gtacaccgcc aagcacatgc caaaattcaa ctcgatctcc      780

atatcaggct accacatgca ggaggccggc gccgacgcca tactggagct ggcgtacacg      840

ctggcggacg gcctcgaata cagccggaca ggcctgcaag ccggactgac catcgacgaa      900

ttcgccccaa gactgagttt cttctggggc atcgggatga acttctacat ggaaatcgca      960

aaaatgagag cgggccgacg gctctgggcg cacctgatcg aaaagatgtt ccagccaaag     1020

aactccaagt ccctcctcct cagagcccac tgccagacat caggctggtc cctcaccgag     1080

caggacccct acaacaacat agtgaggacc gccatcgaag cgatggccgc ggtgttcgga     1140

gggacgcagt ccctgcacac caacagcttc gacgaggcac tcggcctgcc cacggtcaaa     1200

tccgcacgca tcgcccggaa cacacagatc atcatacagg aggagagcgg catcccaaag     1260

gtggcagacc catggggcgg ctcatacatg atggagtgcc tcacgaacga cgtgtacgac     1320

gccgcactga aactcatcaa cgaaatcgaa gagatgggag gaatggcaaa ggcggtggcg     1380

gagggcatcc ccaagctgcg catcgaggaa tgcgccgccc ggcggcaagc ccggatcgac     1440

tcaggatccg aagtgatcgt gggagtgaac aagtaccagc tggaaaagga ggacgcagtg     1500

gaggtcctcg caatcgacaa cacctcagtg cggaaccggc agatcgaaaa gctgaaaaaa     1560

atcaaaagct cacgagacca ggccctggca gagcggtgcc tggcagccct gacagagtgc     1620

gcagccagcg gagacggaaa catcctcgcc ctggcggtgg acgcctcgag agccagatgc     1680

accgtcggcg agatcaccga cgcactgaaa aaggtgttcg gagaacacaa ggcaaacgac     1740

cgaatggtga gtggagcgta ccgccaggaa ttcggggagt ccaaagaaat cacctcggca     1800

ataaagcggg tgcacaaatt catggaaaga gaggggcgga ggcccagact gctcgtggcc     1860

aaaatgggcc aggacggaca cgacagaggc gccaaggtga tcgcgacagg gttcgcggac     1920

ctgggcttcg acgtggacat aggcccgctg ttccagacgc cacgagaggt ggcacaacag     1980

gcggtggacg ccgacgtgca cgcggtgggg gtgtccacac tggccgcagg ccacaaaacg     2040

ctcgtacccg agctgatcaa agagctgaac tcactgggac ggcccgacat cctggtgatg     2100

tgcggcggag tgatcccacc acaggactac gaattcctgt tcgaagtggg ggtctccaac     2160

gtcttcggcc cagggacaag gatccccaag gcagccgtgc aggtgctcga cgacatagag     2220

aaatgcctgg agaagaaaca gcaatcggta                                      2250


<210>  204
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  204
atgctaagag caaagaacca gctgttcctg ctgtcaccac actacctgag acaagtcaag       60

gaaagttccg gcagcagact gatccagcag cggctgctac accaacagca gcccctgcac      120

ccagagtggg cagccctggc caaaaaacag ctgaagggca aaaacccaga ggacctcatc      180

tggcacacac cagaggggat cagtataaag cccctgtaca gtaaaagaga cacaatggac      240

ctccccgaag agctacccgg agtgaagcca ttcacacgag ggccctaccc aaccatgtac      300

accttccggc cctggaccat caggcagtac gccggcttca gcacagtcga ggagagtaac      360

aaattctaca aagacaacat caaggccggg cagcaggggc tgtcagtggc cttcgacctg      420

gccacacacc gggggtacga ctcggacaac ccgagggtga ggggggacgt gggaatggca      480

ggagtggcca tagacaccgt cgaggacacc aagatcctgt tcgacggaat ccccctggaa      540

aagatgtcgg tctccatgac gatgaacggc gccgtcatcc ccgtgctagc caacttcatc      600

gtcaccgggg aggaacaggg agtgccgaaa gagaaactga ccgggacgat ccagaacgac      660

atcctgaaag agttcatggt aagaaacaca tacatattcc caccggaacc cagtatgaag      720

atcatcgcgg acatattcga atacaccgca aaacacatgc ccaagttcaa ctcgatcagc      780

atatccgggt accacatgca ggaagcaggg gccgacgcca tcctggaact cgcctacacc      840

ctagcagacg gactggagta cagccgcacc ggactgcagg cagggctgac gatagacgag      900

ttcgcccccc ggctgagttt cttctgggga atagggatga acttctacat ggagatagcg      960

aagatgcgcg ccggccgccg gctgtgggca cacctgatcg aaaagatgtt ccagcccaag     1020

aactcaaaat cgctgctcct cagggcacac tgccagacaa gcgggtggag cctaaccgag     1080

caagacccgt acaacaacat cgtccgaaca gcaatcgaag ccatggccgc cgtcttcggc     1140

gggacacaga gcctccacac caactcattc gacgaagccc tggggctgcc caccgtcaaa     1200

tcagccagga tcgcccgaaa cacccagatc ataatccagg aagagtcggg gatcccaaag     1260

gtagccgacc cctggggggg atcctacatg atggagtgcc tgaccaacga cgtgtacgac     1320

gccgccctga agctgatcaa cgagatcgag gagatgggag gcatggccaa ggccgtggcg     1380

gaaggaatcc cgaagctgcg catcgaagaa tgcgccgcca gacggcaggc ccggatcgac     1440

tccggatccg aggtgatcgt gggcgtcaac aagtaccagc tggagaagga ggacgccgtc     1500

gaggtgctgg ccatcgacaa caccagcgtg cgaaacaggc agatagaaaa gctcaaaaag     1560

atcaagtcat cgagggacca ggccctggca gagaggtgcc tggcagccct gaccgagtgc     1620

gcggcctccg gagacggcaa catactggcc ctcgccgtgg acgcaagcag agcccgctgc     1680

accgtcggag agataacaga cgccctgaag aaagtgttcg gggagcacaa ggccaacgac     1740

cggatggtga gcggggccta caggcaggaa ttcggggaga gcaaggagat caccagcgcc     1800

atcaaacggg tgcacaaatt catggagagg gaagggcgac gcccccgcct gctcgtggcc     1860

aagatgggac aggacggcca cgaccggggc gcaaaagtga tcgcaaccgg cttcgcggac     1920

ctgggcttcg acgtggacat aggaccactg ttccagacac cgagagaggt ggcccagcag     1980

gcagtggacg cagacgtcca cgccgtaggg gtgtccacac tggccgccgg acacaagacc     2040

ctagtccccg agctgatcaa agagctgaac agtctgggca ggccagacat cctggtcatg     2100

tgcggcgggg tgatcccccc ccaggactac gagttcctat tcgaggtggg agtaagtaac     2160

gtgttcggac ccgggaccag aatcccaaag gcagccgtcc aggtcctgga cgacatcgag     2220

aaatgcctgg aaaagaagca gcagagtgta                                      2250


<210>  205
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  205
atgctgcgcg ctaagaatca actcttcctg ctgagtcctc actacctgcg gcaggtcaag       60

gagtccagcg ggtcccggtt aattcagcag aggctgctcc accagcagca gcccttacac      120

cccgaatggg ccgctcttgc gaagaagcag ctcaagggaa agaaccctga ggacctcatt      180

tggcataccc cagaagggat ttccatcaaa cctctgtatt ccaagagaga taccatggat      240

cttcccgaag agctaccagg agtgaagcct ttcaccaggg gcccctaccc gaccatgtac      300

acctttcggc cttggaccat ccgccaatat gctggattct ccactgtaga agagtccaac      360

aaattttata aagataatat aaaggctggg caacagggct tatccgtcgc tttcgatttg      420

gcaactcata ggggttacga ctcggataat ccacgcgtcc ggggggacgt aggtatggct      480

ggggtggcta tcgacaccgt ggaggatacc aagatccttt tcgatggaat tcccctggag      540

aagatgtccg taagtatgac catgaatggg gcggtcattc ccgtactggc taacttcatt      600

gtcactggag aagaacaggg agtgcccaag gagaagctta caggcacaat ccaaaatgac      660

atcctgaagg agttcatggt tcgcaacacc tacatcttcc cgccagaacc aagtatgaag      720

ataatcgcgg acatcttcga gtatactgcc aaacacatgc ccaaattcaa cagtatctca      780

atttctggct accacatgca ggaggctgga gccgatgcta tcttggaact ggcatatact      840

ctagcagatg gactggagta ctcccgcacc ggcctccagg caggcctcac catagacgag      900

ttcgcgccgc gcttgtcatt tttctggggc atcggtatga acttttacat ggaaatcgcc      960

aagatgcggg caggtcgccg gctttgggca cacctgattg agaagatgtt ccagcctaag     1020

aattctaaat cactgctact gagagcccac tgtcagacct ctggatggtc tctaactgaa     1080

caagatccct ataataacat cgtgcgcacg gcgattgagg ccatggcagc ggtcttcggg     1140

ggcacacaaa gtttgcatac aaacagtttt gatgaggccc ttggcttacc cactgtgaag     1200

tcagctagaa tcgccaggaa tactcagatt attatccaag aggaatccgg cataccaaag     1260

gtggccgacc cctggggggg ctcctatatg atggagtgcc tgactaacga tgtatacgat     1320

gcagccctca aattgattaa tgagatcgaa gaaatgggag ggatggctaa agccgtcgca     1380

gagggaatac ctaaactgcg catcgaagaa tgcgcagcac ggaggcaggc ccggatagat     1440

agtggtagtg aggtgatcgt gggcgtgaac aagtaccagc tggaaaaaga ggatgccgta     1500

gaagtcctgg ctattgataa tacttcagtc cgcaacaggc aaattgagaa actcaagaaa     1560

attaagtcat caagagatca ggccttagct gagcgctgtc tcgctgcact gacagaatgc     1620

gccgctagtg gtgacggcaa tatcctggca ctcgccgttg atgcgtcacg cgcccgttgc     1680

acagtgggcg aaattacaga cgccctcaag aaagtgttcg gagagcacaa ggctaacgat     1740

cgaatggtga gcggagctta caggcaggaa tttggtgaaa gtaaggaaat tacttccgct     1800

atcaaacgcg tgcataaatt catggagcgt gaaggtagga gaccaagact cctggtagcc     1860

aaaatgggac aggatggtca tgaccgcgga gcaaaagtga tcgccaccgg gttcgcagat     1920

ttgggcttcg acgttgacat cggtcctctt ttccagacac cccgagaggt tgcacagcaa     1980

gcagtggacg ctgacgtgca cgcagtgggc gtgtccacac tcgcagcagg tcataaaact     2040

ctggtcccgg agctgattaa ggagctcaat agtctgggac gccctgacat ccttgtcatg     2100

tgcgggggcg tcattccccc gcaggactat gaatttctgt tcgaggttgg ggtcagcaac     2160

gtcttcgggc ccggcaccag aatccctaaa gctgcggtgc aagtgttgga tgacattgag     2220

aagtgcctcg agaagaaaca gcagtccgtc                                      2250


<210>  206
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  206
atgctgcgag cgaagaatca gctgtttctt ctgagtcctc attaccttcg gcaggtgaag       60

gaatcctctg gatcccgtct gatccagcag cgccttctgc accagcaaca gccacttcac      120

cccgagtggg cggcgctggc aaagaagcag ttgaagggga agaaccctga agatctgatt      180

tggcacaccc cggagggtat ctctattaag ccgctttact ccaaacgaga cactatggat      240

ctgccagagg agctgcccgg agtaaagcca tttactcggg gcccatatcc taccatgtac      300

actttccggc catggaccat acgacagtat gctggtttca gcacagtcga ggaaagtaac      360

aaattttata aggacaatat caaagcgggc caacaaggac tcagtgtagc atttgatctc      420

gctacccaca ggggctacga ctccgataac cctagagtcc ggggtgacgt cggaatggca      480

ggcgtcgcca tcgacacggt ggaggatacg aagattctgt ttgacggaat ccccctggag      540

aagatgtcag tttctatgac gatgaatggg gccgttatcc ccgtattggc taacttcatc      600

gtgacaggtg aggagcaggg ggttccgaag gagaagttaa ccggtaccat ccagaatgat      660

atcctgaagg agtttatggt gaggaacacc tacattttcc cccctgagcc ttctatgaag      720

attatcgctg acattttcga gtatactgct aagcacatgc ccaagttcaa ctctatcagc      780

atcagcggtt accacatgca ggaagctgga gccgatgcta ttctcgagct ggcatatacc      840

ctagcggatg gtcttgagta tagtagaacc ggcttgcagg ctggtctgac catcgacgaa      900

tttgctccca gactcagctt cttttggggt atcggcatga acttctacat ggaaatcgct      960

aaaatgagag cagggcggag actctgggcc cacctgatcg agaagatgtt ccagcccaaa     1020

aactctaaat cactgctcct cagggcccac tgtcagacat ccggctggag tttgaccgaa     1080

caggatccct acaataacat tgttagaact gcaatcgaag ctatggccgc agtctttggt     1140

ggcacccaga gtcttcacac taacagtttc gacgaggctt tggggttacc caccgtaaaa     1200

tcagcccgaa ttgcccggaa cacccaaata atcatccagg aagaatccgg aattcctaag     1260

gtggctgatc cttggggcgg gagctatatg atggagtgcc tgaccaacga tgtgtatgac     1320

gctgcgctta aactgattaa tgaaatcgag gagatgggcg gtatggccaa agccgttgcc     1380

gaagggattc ccaaacttag aattgaagaa tgtgcggccc gcagacaagc tcgaattgat     1440

tccggcagcg aagtgattgt gggcgtgaat aagtatcaac tcgagaagga agacgccgtc     1500

gaagtattgg ccatcgacaa tacatccgtg cggaatcgtc agatcgaaaa actgaaaaag     1560

atcaagtcaa gccgcgatca agctctagct gaaaggtgct tagccgcgct gacggagtgt     1620

gccgcttccg gggacggtaa tatcctcgcc ctggctgttg acgcttctag ggcgagatgc     1680

acagtgggcg aaattacaga tgcgttgaaa aaggtattcg gtgagcataa ggctaacgac     1740

cggatggtga gtggcgcgta tcggcaagag ttcggcgagt ctaaagagat tacatccgct     1800

atcaagcggg tgcacaaatt catggagcgg gaggggcgcc gaccgaggtt gttggtagcc     1860

aagatgggac aggacggaca tgatcggggg gctaaggtta ttgccacagg gttcgcagac     1920

ctcggcttcg acgtggatat cgggcccctg ttccagacac cacgcgaggt cgcccaacag     1980

gccgtcgacg cagacgtgca cgcagtgggt gtgagtaccc tggctgccgg acacaaaacc     2040

ctcgtgcccg aacttatcaa ggaattgaac agtcttggca ggccagacat attggttatg     2100

tgtggagggg ttattccccc tcaggactac gagtttttgt tcgaagtggg cgtgagcaat     2160

gtgtttggcc ctgggacacg aatccctaag gccgcggtac aggtgctgga cgatatcgag     2220

aaatgtctgg agaagaaaca gcagtctgtg                                      2250


<210>  207
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  207
atgctgaggg caaaaaatca actgttcctg cttagcccgc attacctgag gcaggtgaaa       60

gagtctagtg gatctaggct gattcagcaa cgcctcctgc accaacagca accgttacac      120

cccgagtggg ccgccctggc taaaaaacag ctgaagggta aaaatcccga agatcttatt      180

tggcataccc ctgagggaat atcaatcaag ccgctgtatt ccaaacggga caccatggat      240

cttcccgaag agctgcccgg ggtgaaacca ttcactcggg gaccctaccc aactatgtac      300

acgttccggc catggaccat caggcagtac gccggtttct caaccgtgga ggagtccaat      360

aagttttata aggacaatat taaagccggt cagcagggcc tgtccgtggc tttcgatctt      420

gccacgcatc gaggatacga ctcggacaac ccccgggtcc gcggcgatgt gggcatggct      480

ggcgtagcta tcgacactgt tgaggatacc aaaatcttat tcgatggaat accacttgag      540

aaaatgagtg tgagtatgac aatgaatggc gccgttattc cggttctagc caattttatt      600

gtgacaggcg aggaacaagg tgttccgaag gagaagctga ctgggacaat ccaaaacgat      660

attttaaaag agtttatggt gcgtaatacc tacatttttc cacccgaacc ctcaatgaaa      720

attatagcag atatctttga atatacggct aagcacatgc caaagttcaa ctctatcagt      780

atttcaggct accacatgca ggaggctggg gccgacgcta ttcttgagct cgcctataca      840

ctcgctgacg ggttggagta tagccgcacc ggtctccagg caggactgac cattgacgaa      900

ttcgcaccac gactctcttt cttctggggc atcggcatga acttttacat ggaaattgcc      960

aagatgagag ccgggcggcg actttgggcc catctgatcg agaagatgtt ccagccgaaa     1020

aactctaaat ctttgctgtt gcgcgctcat tgccagactt caggttggtc acttactgag     1080

caggatcctt acaacaatat agtgcgtacc gccattgagg ctatggccgc tgtctttggg     1140

gggacccagt cgctgcacac caacagtttt gatgaagctc tggggctacc aaccgttaag     1200

tctgctcgga tcgcacgaaa tacccagatt ataatccagg aagaatccgg gatcccaaaa     1260

gtggccgatc cctggggcgg cagttacatg atggagtgcc tcacaaatga tgtatatgac     1320

gcagccctta agcttataaa cgaaattgaa gaaatgggcg gaatggccaa ggcagttgcg     1380

gagggaatac ctaagcttcg gatcgaagag tgtgctgcac ggcgtcaggc tcgcatagat     1440

tccgggtcag aggtgatcgt tggagtgaac aaatatcaat tggaaaagga agatgcagtg     1500

gaggtattgg ccatcgacaa tacctccgtt cggaacaggc agatagagaa acttaaaaag     1560

attaagagct ctcgtgacca agctctcgca gagaggtgcc tggccgctct gactgagtgc     1620

gccgccagcg gagacgggaa tatactcgcc ttggcagtcg acgcgagccg agcccggtgc     1680

acagtgggag aaatcactga tgccctaaag aaagtgttcg gcgaacacaa ggctaatgac     1740

cgaatggtga gcggagccta ccgtcaggag tttggtgaaa gcaaggaaat cacctctgct     1800

atcaagcggg tgcacaagtt tatggagaga gaaggcagga gacctcgctt gcttgtggcc     1860

aagatgggcc aggacgggca tgacaggggt gccaaggtga tcgcaacagg gttcgccgac     1920

ttgggcttcg acgtcgatat cgggcccctg tttcagactc ctcgagaggt tgcacagcaa     1980

gcggtggatg ctgatgttca tgccgttggt gtaagcactc tggcggccgg acacaaaacc     2040

ctcgtcccag aattaataaa ggagttgaat agcctgggcc ggcccgatat tctcgtaatg     2100

tgcggcggag tgataccgcc gcaggactat gagtttttgt ttgaggtagg cgtcagtaat     2160

gtgttcggac ctggtacccg gattccaaag gcagcggtgc aggtgcttga cgatatcgaa     2220

aagtgcctgg aaaagaaaca gcagtccgtc                                      2250


<210>  208
<211>  750
<212>  PRT
<213>  Homo Sapian

<400>  208

Met Leu Arg Ala Lys Asn Gln Leu Phe Leu Leu Ser Pro His Tyr Leu 
1               5                   10                  15      


Arg Gln Val Lys Glu Ser Ser Gly Ser Arg Leu Ile Gln Gln Arg Leu 
            20                  25                  30          


Leu His Gln Gln Gln Pro Leu His Pro Glu Trp Ala Ala Leu Ala Lys 
        35                  40                  45              


Lys Gln Leu Lys Gly Lys Asn Pro Glu Asp Leu Ile Trp His Thr Pro 
    50                  55                  60                  


Glu Gly Ile Ser Ile Lys Pro Leu Tyr Ser Lys Arg Asp Thr Met Asp 
65                  70                  75                  80  


Leu Pro Glu Glu Leu Pro Gly Val Lys Pro Phe Thr Arg Gly Pro Tyr 
                85                  90                  95      


Pro Thr Met Tyr Thr Phe Arg Pro Trp Thr Ile Arg Gln Tyr Ala Gly 
            100                 105                 110         


Phe Ser Thr Val Glu Glu Ser Asn Lys Phe Tyr Lys Asp Asn Ile Lys 
        115                 120                 125             


Ala Gly Gln Gln Gly Leu Ser Val Ala Phe Asp Leu Ala Thr His Arg 
    130                 135                 140                 


Gly Tyr Asp Ser Asp Asn Pro Arg Val Arg Gly Asp Val Gly Met Ala 
145                 150                 155                 160 


Gly Val Ala Ile Asp Thr Val Glu Asp Thr Lys Ile Leu Phe Asp Gly 
                165                 170                 175     


Ile Pro Leu Glu Lys Met Ser Val Ser Met Thr Met Asn Gly Ala Val 
            180                 185                 190         


Ile Pro Val Leu Ala Asn Phe Ile Val Thr Gly Glu Glu Gln Gly Val 
        195                 200                 205             


Pro Lys Glu Lys Leu Thr Gly Thr Ile Gln Asn Asp Ile Leu Lys Glu 
    210                 215                 220                 


Phe Met Val Arg Asn Thr Tyr Ile Phe Pro Pro Glu Pro Ser Met Lys 
225                 230                 235                 240 


Ile Ile Ala Asp Ile Phe Glu Tyr Thr Ala Lys His Met Pro Lys Phe 
                245                 250                 255     


Asn Ser Ile Ser Ile Ser Gly Tyr His Met Gln Glu Ala Gly Ala Asp 
            260                 265                 270         


Ala Ile Leu Glu Leu Ala Tyr Thr Leu Ala Asp Gly Leu Glu Tyr Ser 
        275                 280                 285             


Arg Thr Gly Leu Gln Ala Gly Leu Thr Ile Asp Glu Phe Ala Pro Arg 
    290                 295                 300                 


Leu Ser Phe Phe Trp Gly Ile Gly Met Asn Phe Tyr Met Glu Ile Ala 
305                 310                 315                 320 


Lys Met Arg Ala Gly Arg Arg Leu Trp Ala His Leu Ile Glu Lys Met 
                325                 330                 335     


Phe Gln Pro Lys Asn Ser Lys Ser Leu Leu Leu Arg Ala His Cys Gln 
            340                 345                 350         


Thr Ser Gly Trp Ser Leu Thr Glu Gln Asp Pro Tyr Asn Asn Ile Val 
        355                 360                 365             


Arg Thr Ala Ile Glu Ala Met Ala Ala Val Phe Gly Gly Thr Gln Ser 
    370                 375                 380                 


Leu His Thr Asn Ser Phe Asp Glu Ala Leu Gly Leu Pro Thr Val Lys 
385                 390                 395                 400 


Ser Ala Arg Ile Ala Arg Asn Thr Gln Ile Ile Ile Gln Glu Glu Ser 
                405                 410                 415     


Gly Ile Pro Lys Val Ala Asp Pro Trp Gly Gly Ser Tyr Met Met Glu 
            420                 425                 430         


Cys Leu Thr Asn Asp Val Tyr Asp Ala Ala Leu Lys Leu Ile Asn Glu 
        435                 440                 445             


Ile Glu Glu Met Gly Gly Met Ala Lys Ala Val Ala Glu Gly Ile Pro 
    450                 455                 460                 


Lys Leu Arg Ile Glu Glu Cys Ala Ala Arg Arg Gln Ala Arg Ile Asp 
465                 470                 475                 480 


Ser Gly Ser Glu Val Ile Val Gly Val Asn Lys Tyr Gln Leu Glu Lys 
                485                 490                 495     


Glu Asp Ala Val Glu Val Leu Ala Ile Asp Asn Thr Ser Val Arg Asn 
            500                 505                 510         


Arg Gln Ile Glu Lys Leu Lys Lys Ile Lys Ser Ser Arg Asp Gln Ala 
        515                 520                 525             


Leu Ala Glu Arg Cys Leu Ala Ala Leu Thr Glu Cys Ala Ala Ser Gly 
    530                 535                 540                 


Asp Gly Asn Ile Leu Ala Leu Ala Val Asp Ala Ser Arg Ala Arg Cys 
545                 550                 555                 560 


Thr Val Gly Glu Ile Thr Asp Ala Leu Lys Lys Val Phe Gly Glu His 
                565                 570                 575     


Lys Ala Asn Asp Arg Met Val Ser Gly Ala Tyr Arg Gln Glu Phe Gly 
            580                 585                 590         


Glu Ser Lys Glu Ile Thr Ser Ala Ile Lys Arg Val His Lys Phe Met 
        595                 600                 605             


Glu Arg Glu Gly Arg Arg Pro Arg Leu Leu Val Ala Lys Met Gly Gln 
    610                 615                 620                 


Asp Gly His Asp Arg Gly Ala Lys Val Ile Ala Thr Gly Phe Ala Asp 
625                 630                 635                 640 


Leu Gly Phe Asp Val Asp Ile Gly Pro Leu Phe Gln Thr Pro Arg Glu 
                645                 650                 655     


Val Ala Gln Gln Ala Val Asp Ala Asp Val His Ala Val Gly Ile Ser 
            660                 665                 670         


Thr Leu Ala Ala Gly His Lys Thr Leu Val Pro Glu Leu Ile Lys Glu 
        675                 680                 685             


Leu Asn Ser Leu Gly Arg Pro Asp Ile Leu Val Met Cys Gly Gly Val 
    690                 695                 700                 


Ile Pro Pro Gln Asp Tyr Glu Phe Leu Phe Glu Val Gly Val Ser Asn 
705                 710                 715                 720 


Val Phe Gly Pro Gly Thr Arg Ile Pro Lys Ala Ala Val Gln Val Leu 
                725                 730                 735     


Asp Asp Ile Glu Lys Cys Leu Glu Lys Lys Gln Gln Ser Val 
            740                 745                 750 


<210>  209
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MCM I69V

<400>  209

Met Leu Arg Ala Lys Asn Gln Leu Phe Leu Leu Ser Pro His Tyr Leu 
1               5                   10                  15      


Arg Gln Val Lys Glu Ser Ser Gly Ser Arg Leu Ile Gln Gln Arg Leu 
            20                  25                  30          


Leu His Gln Gln Gln Pro Leu His Pro Glu Trp Ala Ala Leu Ala Lys 
        35                  40                  45              


Lys Gln Leu Lys Gly Lys Asn Pro Glu Asp Leu Ile Trp His Thr Pro 
    50                  55                  60                  


Glu Gly Ile Ser Val Lys Pro Leu Tyr Ser Lys Arg Asp Thr Met Asp 
65                  70                  75                  80  


Leu Pro Glu Glu Leu Pro Gly Val Lys Pro Phe Thr Arg Gly Pro Tyr 
                85                  90                  95      


Pro Thr Met Tyr Thr Phe Arg Pro Trp Thr Ile Arg Gln Tyr Ala Gly 
            100                 105                 110         


Phe Ser Thr Val Glu Glu Ser Asn Lys Phe Tyr Lys Asp Asn Ile Lys 
        115                 120                 125             


Ala Gly Gln Gln Gly Leu Ser Val Ala Phe Asp Leu Ala Thr His Arg 
    130                 135                 140                 


Gly Tyr Asp Ser Asp Asn Pro Arg Val Arg Gly Asp Val Gly Met Ala 
145                 150                 155                 160 


Gly Val Ala Ile Asp Thr Val Glu Asp Thr Lys Ile Leu Phe Asp Gly 
                165                 170                 175     


Ile Pro Leu Glu Lys Met Ser Val Ser Met Thr Met Asn Gly Ala Val 
            180                 185                 190         


Ile Pro Val Leu Ala Asn Phe Ile Val Thr Gly Glu Glu Gln Gly Val 
        195                 200                 205             


Pro Lys Glu Lys Leu Thr Gly Thr Ile Gln Asn Asp Ile Leu Lys Glu 
    210                 215                 220                 


Phe Met Val Arg Asn Thr Tyr Ile Phe Pro Pro Glu Pro Ser Met Lys 
225                 230                 235                 240 


Ile Ile Ala Asp Ile Phe Glu Tyr Thr Ala Lys His Met Pro Lys Phe 
                245                 250                 255     


Asn Ser Ile Ser Ile Ser Gly Tyr His Met Gln Glu Ala Gly Ala Asp 
            260                 265                 270         


Ala Ile Leu Glu Leu Ala Tyr Thr Leu Ala Asp Gly Leu Glu Tyr Ser 
        275                 280                 285             


Arg Thr Gly Leu Gln Ala Gly Leu Thr Ile Asp Glu Phe Ala Pro Arg 
    290                 295                 300                 


Leu Ser Phe Phe Trp Gly Ile Gly Met Asn Phe Tyr Met Glu Ile Ala 
305                 310                 315                 320 


Lys Met Arg Ala Gly Arg Arg Leu Trp Ala His Leu Ile Glu Lys Met 
                325                 330                 335     


Phe Gln Pro Lys Asn Ser Lys Ser Leu Leu Leu Arg Ala His Cys Gln 
            340                 345                 350         


Thr Ser Gly Trp Ser Leu Thr Glu Gln Asp Pro Tyr Asn Asn Ile Val 
        355                 360                 365             


Arg Thr Ala Ile Glu Ala Met Ala Ala Val Phe Gly Gly Thr Gln Ser 
    370                 375                 380                 


Leu His Thr Asn Ser Phe Asp Glu Ala Leu Gly Leu Pro Thr Val Lys 
385                 390                 395                 400 


Ser Ala Arg Ile Ala Arg Asn Thr Gln Ile Ile Ile Gln Glu Glu Ser 
                405                 410                 415     


Gly Ile Pro Lys Val Ala Asp Pro Trp Gly Gly Ser Tyr Met Met Glu 
            420                 425                 430         


Cys Leu Thr Asn Asp Val Tyr Asp Ala Ala Leu Lys Leu Ile Asn Glu 
        435                 440                 445             


Ile Glu Glu Met Gly Gly Met Ala Lys Ala Val Ala Glu Gly Ile Pro 
    450                 455                 460                 


Lys Leu Arg Ile Glu Glu Cys Ala Ala Arg Arg Gln Ala Arg Ile Asp 
465                 470                 475                 480 


Ser Gly Ser Glu Val Ile Val Gly Val Asn Lys Tyr Gln Leu Glu Lys 
                485                 490                 495     


Glu Asp Ala Val Glu Val Leu Ala Ile Asp Asn Thr Ser Val Arg Asn 
            500                 505                 510         


Arg Gln Ile Glu Lys Leu Lys Lys Ile Lys Ser Ser Arg Asp Gln Ala 
        515                 520                 525             


Leu Ala Glu Arg Cys Leu Ala Ala Leu Thr Glu Cys Ala Ala Ser Gly 
    530                 535                 540                 


Asp Gly Asn Ile Leu Ala Leu Ala Val Asp Ala Ser Arg Ala Arg Cys 
545                 550                 555                 560 


Thr Val Gly Glu Ile Thr Asp Ala Leu Lys Lys Val Phe Gly Glu His 
                565                 570                 575     


Lys Ala Asn Asp Arg Met Val Ser Gly Ala Tyr Arg Gln Glu Phe Gly 
            580                 585                 590         


Glu Ser Lys Glu Ile Thr Ser Ala Ile Lys Arg Val His Lys Phe Met 
        595                 600                 605             


Glu Arg Glu Gly Arg Arg Pro Arg Leu Leu Val Ala Lys Met Gly Gln 
    610                 615                 620                 


Asp Gly His Asp Arg Gly Ala Lys Val Ile Ala Thr Gly Phe Ala Asp 
625                 630                 635                 640 


Leu Gly Phe Asp Val Asp Ile Gly Pro Leu Phe Gln Thr Pro Arg Glu 
                645                 650                 655     


Val Ala Gln Gln Ala Val Asp Ala Asp Val His Ala Val Gly Ile Ser 
            660                 665                 670         


Thr Leu Ala Ala Gly His Lys Thr Leu Val Pro Glu Leu Ile Lys Glu 
        675                 680                 685             


Leu Asn Ser Leu Gly Arg Pro Asp Ile Leu Val Met Cys Gly Gly Val 
    690                 695                 700                 


Ile Pro Pro Gln Asp Tyr Glu Phe Leu Phe Glu Val Gly Val Ser Asn 
705                 710                 715                 720 


Val Phe Gly Pro Gly Thr Arg Ile Pro Lys Ala Ala Val Gln Val Leu 
                725                 730                 735     


Asp Asp Ile Glu Lys Cys Leu Glu Lys Lys Gln Gln Ser Val 
            740                 745                 750 


<210>  210
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MCM A499T

<400>  210

Met Leu Arg Ala Lys Asn Gln Leu Phe Leu Leu Ser Pro His Tyr Leu 
1               5                   10                  15      


Arg Gln Val Lys Glu Ser Ser Gly Ser Arg Leu Ile Gln Gln Arg Leu 
            20                  25                  30          


Leu His Gln Gln Gln Pro Leu His Pro Glu Trp Ala Ala Leu Ala Lys 
        35                  40                  45              


Lys Gln Leu Lys Gly Lys Asn Pro Glu Asp Leu Ile Trp His Thr Pro 
    50                  55                  60                  


Glu Gly Ile Ser Ile Lys Pro Leu Tyr Ser Lys Arg Asp Thr Met Asp 
65                  70                  75                  80  


Leu Pro Glu Glu Leu Pro Gly Val Lys Pro Phe Thr Arg Gly Pro Tyr 
                85                  90                  95      


Pro Thr Met Tyr Thr Phe Arg Pro Trp Thr Ile Arg Gln Tyr Ala Gly 
            100                 105                 110         


Phe Ser Thr Val Glu Glu Ser Asn Lys Phe Tyr Lys Asp Asn Ile Lys 
        115                 120                 125             


Ala Gly Gln Gln Gly Leu Ser Val Ala Phe Asp Leu Ala Thr His Arg 
    130                 135                 140                 


Gly Tyr Asp Ser Asp Asn Pro Arg Val Arg Gly Asp Val Gly Met Ala 
145                 150                 155                 160 


Gly Val Ala Ile Asp Thr Val Glu Asp Thr Lys Ile Leu Phe Asp Gly 
                165                 170                 175     


Ile Pro Leu Glu Lys Met Ser Val Ser Met Thr Met Asn Gly Ala Val 
            180                 185                 190         


Ile Pro Val Leu Ala Asn Phe Ile Val Thr Gly Glu Glu Gln Gly Val 
        195                 200                 205             


Pro Lys Glu Lys Leu Thr Gly Thr Ile Gln Asn Asp Ile Leu Lys Glu 
    210                 215                 220                 


Phe Met Val Arg Asn Thr Tyr Ile Phe Pro Pro Glu Pro Ser Met Lys 
225                 230                 235                 240 


Ile Ile Ala Asp Ile Phe Glu Tyr Thr Ala Lys His Met Pro Lys Phe 
                245                 250                 255     


Asn Ser Ile Ser Ile Ser Gly Tyr His Met Gln Glu Ala Gly Ala Asp 
            260                 265                 270         


Ala Ile Leu Glu Leu Ala Tyr Thr Leu Ala Asp Gly Leu Glu Tyr Ser 
        275                 280                 285             


Arg Thr Gly Leu Gln Ala Gly Leu Thr Ile Asp Glu Phe Ala Pro Arg 
    290                 295                 300                 


Leu Ser Phe Phe Trp Gly Ile Gly Met Asn Phe Tyr Met Glu Ile Ala 
305                 310                 315                 320 


Lys Met Arg Ala Gly Arg Arg Leu Trp Ala His Leu Ile Glu Lys Met 
                325                 330                 335     


Phe Gln Pro Lys Asn Ser Lys Ser Leu Leu Leu Arg Ala His Cys Gln 
            340                 345                 350         


Thr Ser Gly Trp Ser Leu Thr Glu Gln Asp Pro Tyr Asn Asn Ile Val 
        355                 360                 365             


Arg Thr Ala Ile Glu Ala Met Ala Ala Val Phe Gly Gly Thr Gln Ser 
    370                 375                 380                 


Leu His Thr Asn Ser Phe Asp Glu Ala Leu Gly Leu Pro Thr Val Lys 
385                 390                 395                 400 


Ser Ala Arg Ile Ala Arg Asn Thr Gln Ile Ile Ile Gln Glu Glu Ser 
                405                 410                 415     


Gly Ile Pro Lys Val Ala Asp Pro Trp Gly Gly Ser Tyr Met Met Glu 
            420                 425                 430         


Cys Leu Thr Asn Asp Val Tyr Asp Ala Ala Leu Lys Leu Ile Asn Glu 
        435                 440                 445             


Ile Glu Glu Met Gly Gly Met Ala Lys Ala Val Ala Glu Gly Ile Pro 
    450                 455                 460                 


Lys Leu Arg Ile Glu Glu Cys Ala Ala Arg Arg Gln Ala Arg Ile Asp 
465                 470                 475                 480 


Ser Gly Ser Glu Val Ile Val Gly Val Asn Lys Tyr Gln Leu Glu Lys 
                485                 490                 495     


Glu Asp Thr Val Glu Val Leu Ala Ile Asp Asn Thr Ser Val Arg Asn 
            500                 505                 510         


Arg Gln Ile Glu Lys Leu Lys Lys Ile Lys Ser Ser Arg Asp Gln Ala 
        515                 520                 525             


Leu Ala Glu Arg Cys Leu Ala Ala Leu Thr Glu Cys Ala Ala Ser Gly 
    530                 535                 540                 


Asp Gly Asn Ile Leu Ala Leu Ala Val Asp Ala Ser Arg Ala Arg Cys 
545                 550                 555                 560 


Thr Val Gly Glu Ile Thr Asp Ala Leu Lys Lys Val Phe Gly Glu His 
                565                 570                 575     


Lys Ala Asn Asp Arg Met Val Ser Gly Ala Tyr Arg Gln Glu Phe Gly 
            580                 585                 590         


Glu Ser Lys Glu Ile Thr Ser Ala Ile Lys Arg Val His Lys Phe Met 
        595                 600                 605             


Glu Arg Glu Gly Arg Arg Pro Arg Leu Leu Val Ala Lys Met Gly Gln 
    610                 615                 620                 


Asp Gly His Asp Arg Gly Ala Lys Val Ile Ala Thr Gly Phe Ala Asp 
625                 630                 635                 640 


Leu Gly Phe Asp Val Asp Ile Gly Pro Leu Phe Gln Thr Pro Arg Glu 
                645                 650                 655     


Val Ala Gln Gln Ala Val Asp Ala Asp Val His Ala Val Gly Ile Ser 
            660                 665                 670         


Thr Leu Ala Ala Gly His Lys Thr Leu Val Pro Glu Leu Ile Lys Glu 
        675                 680                 685             


Leu Asn Ser Leu Gly Arg Pro Asp Ile Leu Val Met Cys Gly Gly Val 
    690                 695                 700                 


Ile Pro Pro Gln Asp Tyr Glu Phe Leu Phe Glu Val Gly Val Ser Asn 
705                 710                 715                 720 


Val Phe Gly Pro Gly Thr Arg Ile Pro Lys Ala Ala Val Gln Val Leu 
                725                 730                 735     


Asp Asp Ile Glu Lys Cys Leu Glu Lys Lys Gln Gln Ser Val 
            740                 745                 750 


<210>  211
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MCM R532H

<400>  211

Met Leu Arg Ala Lys Asn Gln Leu Phe Leu Leu Ser Pro His Tyr Leu 
1               5                   10                  15      


Arg Gln Val Lys Glu Ser Ser Gly Ser Arg Leu Ile Gln Gln Arg Leu 
            20                  25                  30          


Leu His Gln Gln Gln Pro Leu His Pro Glu Trp Ala Ala Leu Ala Lys 
        35                  40                  45              


Lys Gln Leu Lys Gly Lys Asn Pro Glu Asp Leu Ile Trp His Thr Pro 
    50                  55                  60                  


Glu Gly Ile Ser Ile Lys Pro Leu Tyr Ser Lys Arg Asp Thr Met Asp 
65                  70                  75                  80  


Leu Pro Glu Glu Leu Pro Gly Val Lys Pro Phe Thr Arg Gly Pro Tyr 
                85                  90                  95      


Pro Thr Met Tyr Thr Phe Arg Pro Trp Thr Ile Arg Gln Tyr Ala Gly 
            100                 105                 110         


Phe Ser Thr Val Glu Glu Ser Asn Lys Phe Tyr Lys Asp Asn Ile Lys 
        115                 120                 125             


Ala Gly Gln Gln Gly Leu Ser Val Ala Phe Asp Leu Ala Thr His Arg 
    130                 135                 140                 


Gly Tyr Asp Ser Asp Asn Pro Arg Val Arg Gly Asp Val Gly Met Ala 
145                 150                 155                 160 


Gly Val Ala Ile Asp Thr Val Glu Asp Thr Lys Ile Leu Phe Asp Gly 
                165                 170                 175     


Ile Pro Leu Glu Lys Met Ser Val Ser Met Thr Met Asn Gly Ala Val 
            180                 185                 190         


Ile Pro Val Leu Ala Asn Phe Ile Val Thr Gly Glu Glu Gln Gly Val 
        195                 200                 205             


Pro Lys Glu Lys Leu Thr Gly Thr Ile Gln Asn Asp Ile Leu Lys Glu 
    210                 215                 220                 


Phe Met Val Arg Asn Thr Tyr Ile Phe Pro Pro Glu Pro Ser Met Lys 
225                 230                 235                 240 


Ile Ile Ala Asp Ile Phe Glu Tyr Thr Ala Lys His Met Pro Lys Phe 
                245                 250                 255     


Asn Ser Ile Ser Ile Ser Gly Tyr His Met Gln Glu Ala Gly Ala Asp 
            260                 265                 270         


Ala Ile Leu Glu Leu Ala Tyr Thr Leu Ala Asp Gly Leu Glu Tyr Ser 
        275                 280                 285             


Arg Thr Gly Leu Gln Ala Gly Leu Thr Ile Asp Glu Phe Ala Pro Arg 
    290                 295                 300                 


Leu Ser Phe Phe Trp Gly Ile Gly Met Asn Phe Tyr Met Glu Ile Ala 
305                 310                 315                 320 


Lys Met Arg Ala Gly Arg Arg Leu Trp Ala His Leu Ile Glu Lys Met 
                325                 330                 335     


Phe Gln Pro Lys Asn Ser Lys Ser Leu Leu Leu Arg Ala His Cys Gln 
            340                 345                 350         


Thr Ser Gly Trp Ser Leu Thr Glu Gln Asp Pro Tyr Asn Asn Ile Val 
        355                 360                 365             


Arg Thr Ala Ile Glu Ala Met Ala Ala Val Phe Gly Gly Thr Gln Ser 
    370                 375                 380                 


Leu His Thr Asn Ser Phe Asp Glu Ala Leu Gly Leu Pro Thr Val Lys 
385                 390                 395                 400 


Ser Ala Arg Ile Ala Arg Asn Thr Gln Ile Ile Ile Gln Glu Glu Ser 
                405                 410                 415     


Gly Ile Pro Lys Val Ala Asp Pro Trp Gly Gly Ser Tyr Met Met Glu 
            420                 425                 430         


Cys Leu Thr Asn Asp Val Tyr Asp Ala Ala Leu Lys Leu Ile Asn Glu 
        435                 440                 445             


Ile Glu Glu Met Gly Gly Met Ala Lys Ala Val Ala Glu Gly Ile Pro 
    450                 455                 460                 


Lys Leu Arg Ile Glu Glu Cys Ala Ala Arg Arg Gln Ala Arg Ile Asp 
465                 470                 475                 480 


Ser Gly Ser Glu Val Ile Val Gly Val Asn Lys Tyr Gln Leu Glu Lys 
                485                 490                 495     


Glu Asp Ala Val Glu Val Leu Ala Ile Asp Asn Thr Ser Val Arg Asn 
            500                 505                 510         


Arg Gln Ile Glu Lys Leu Lys Lys Ile Lys Ser Ser Arg Asp Gln Ala 
        515                 520                 525             


Leu Ala Glu His Cys Leu Ala Ala Leu Thr Glu Cys Ala Ala Ser Gly 
    530                 535                 540                 


Asp Gly Asn Ile Leu Ala Leu Ala Val Asp Ala Ser Arg Ala Arg Cys 
545                 550                 555                 560 


Thr Val Gly Glu Ile Thr Asp Ala Leu Lys Lys Val Phe Gly Glu His 
                565                 570                 575     


Lys Ala Asn Asp Arg Met Val Ser Gly Ala Tyr Arg Gln Glu Phe Gly 
            580                 585                 590         


Glu Ser Lys Glu Ile Thr Ser Ala Ile Lys Arg Val His Lys Phe Met 
        595                 600                 605             


Glu Arg Glu Gly Arg Arg Pro Arg Leu Leu Val Ala Lys Met Gly Gln 
    610                 615                 620                 


Asp Gly His Asp Arg Gly Ala Lys Val Ile Ala Thr Gly Phe Ala Asp 
625                 630                 635                 640 


Leu Gly Phe Asp Val Asp Ile Gly Pro Leu Phe Gln Thr Pro Arg Glu 
                645                 650                 655     


Val Ala Gln Gln Ala Val Asp Ala Asp Val His Ala Val Gly Ile Ser 
            660                 665                 670         


Thr Leu Ala Ala Gly His Lys Thr Leu Val Pro Glu Leu Ile Lys Glu 
        675                 680                 685             


Leu Asn Ser Leu Gly Arg Pro Asp Ile Leu Val Met Cys Gly Gly Val 
    690                 695                 700                 


Ile Pro Pro Gln Asp Tyr Glu Phe Leu Phe Glu Val Gly Val Ser Asn 
705                 710                 715                 720 


Val Phe Gly Pro Gly Thr Arg Ile Pro Lys Ala Ala Val Gln Val Leu 
                725                 730                 735     


Asp Asp Ile Glu Lys Cys Leu Glu Lys Lys Gln Gln Ser Val 
            740                 745                 750 


<210>  212
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MCM T598A

<400>  212

Met Leu Arg Ala Lys Asn Gln Leu Phe Leu Leu Ser Pro His Tyr Leu 
1               5                   10                  15      


Arg Gln Val Lys Glu Ser Ser Gly Ser Arg Leu Ile Gln Gln Arg Leu 
            20                  25                  30          


Leu His Gln Gln Gln Pro Leu His Pro Glu Trp Ala Ala Leu Ala Lys 
        35                  40                  45              


Lys Gln Leu Lys Gly Lys Asn Pro Glu Asp Leu Ile Trp His Thr Pro 
    50                  55                  60                  


Glu Gly Ile Ser Ile Lys Pro Leu Tyr Ser Lys Arg Asp Thr Met Asp 
65                  70                  75                  80  


Leu Pro Glu Glu Leu Pro Gly Val Lys Pro Phe Thr Arg Gly Pro Tyr 
                85                  90                  95      


Pro Thr Met Tyr Thr Phe Arg Pro Trp Thr Ile Arg Gln Tyr Ala Gly 
            100                 105                 110         


Phe Ser Thr Val Glu Glu Ser Asn Lys Phe Tyr Lys Asp Asn Ile Lys 
        115                 120                 125             


Ala Gly Gln Gln Gly Leu Ser Val Ala Phe Asp Leu Ala Thr His Arg 
    130                 135                 140                 


Gly Tyr Asp Ser Asp Asn Pro Arg Val Arg Gly Asp Val Gly Met Ala 
145                 150                 155                 160 


Gly Val Ala Ile Asp Thr Val Glu Asp Thr Lys Ile Leu Phe Asp Gly 
                165                 170                 175     


Ile Pro Leu Glu Lys Met Ser Val Ser Met Thr Met Asn Gly Ala Val 
            180                 185                 190         


Ile Pro Val Leu Ala Asn Phe Ile Val Thr Gly Glu Glu Gln Gly Val 
        195                 200                 205             


Pro Lys Glu Lys Leu Thr Gly Thr Ile Gln Asn Asp Ile Leu Lys Glu 
    210                 215                 220                 


Phe Met Val Arg Asn Thr Tyr Ile Phe Pro Pro Glu Pro Ser Met Lys 
225                 230                 235                 240 


Ile Ile Ala Asp Ile Phe Glu Tyr Thr Ala Lys His Met Pro Lys Phe 
                245                 250                 255     


Asn Ser Ile Ser Ile Ser Gly Tyr His Met Gln Glu Ala Gly Ala Asp 
            260                 265                 270         


Ala Ile Leu Glu Leu Ala Tyr Thr Leu Ala Asp Gly Leu Glu Tyr Ser 
        275                 280                 285             


Arg Thr Gly Leu Gln Ala Gly Leu Thr Ile Asp Glu Phe Ala Pro Arg 
    290                 295                 300                 


Leu Ser Phe Phe Trp Gly Ile Gly Met Asn Phe Tyr Met Glu Ile Ala 
305                 310                 315                 320 


Lys Met Arg Ala Gly Arg Arg Leu Trp Ala His Leu Ile Glu Lys Met 
                325                 330                 335     


Phe Gln Pro Lys Asn Ser Lys Ser Leu Leu Leu Arg Ala His Cys Gln 
            340                 345                 350         


Thr Ser Gly Trp Ser Leu Thr Glu Gln Asp Pro Tyr Asn Asn Ile Val 
        355                 360                 365             


Arg Thr Ala Ile Glu Ala Met Ala Ala Val Phe Gly Gly Thr Gln Ser 
    370                 375                 380                 


Leu His Thr Asn Ser Phe Asp Glu Ala Leu Gly Leu Pro Thr Val Lys 
385                 390                 395                 400 


Ser Ala Arg Ile Ala Arg Asn Thr Gln Ile Ile Ile Gln Glu Glu Ser 
                405                 410                 415     


Gly Ile Pro Lys Val Ala Asp Pro Trp Gly Gly Ser Tyr Met Met Glu 
            420                 425                 430         


Cys Leu Thr Asn Asp Val Tyr Asp Ala Ala Leu Lys Leu Ile Asn Glu 
        435                 440                 445             


Ile Glu Glu Met Gly Gly Met Ala Lys Ala Val Ala Glu Gly Ile Pro 
    450                 455                 460                 


Lys Leu Arg Ile Glu Glu Cys Ala Ala Arg Arg Gln Ala Arg Ile Asp 
465                 470                 475                 480 


Ser Gly Ser Glu Val Ile Val Gly Val Asn Lys Tyr Gln Leu Glu Lys 
                485                 490                 495     


Glu Asp Ala Val Glu Val Leu Ala Ile Asp Asn Thr Ser Val Arg Asn 
            500                 505                 510         


Arg Gln Ile Glu Lys Leu Lys Lys Ile Lys Ser Ser Arg Asp Gln Ala 
        515                 520                 525             


Leu Ala Glu Arg Cys Leu Ala Ala Leu Thr Glu Cys Ala Ala Ser Gly 
    530                 535                 540                 


Asp Gly Asn Ile Leu Ala Leu Ala Val Asp Ala Ser Arg Ala Arg Cys 
545                 550                 555                 560 


Thr Val Gly Glu Ile Thr Asp Ala Leu Lys Lys Val Phe Gly Glu His 
                565                 570                 575     


Lys Ala Asn Asp Arg Met Val Ser Gly Ala Tyr Arg Gln Glu Phe Gly 
            580                 585                 590         


Glu Ser Lys Glu Ile Ala Ser Ala Ile Lys Arg Val His Lys Phe Met 
        595                 600                 605             


Glu Arg Glu Gly Arg Arg Pro Arg Leu Leu Val Ala Lys Met Gly Gln 
    610                 615                 620                 


Asp Gly His Asp Arg Gly Ala Lys Val Ile Ala Thr Gly Phe Ala Asp 
625                 630                 635                 640 


Leu Gly Phe Asp Val Asp Ile Gly Pro Leu Phe Gln Thr Pro Arg Glu 
                645                 650                 655     


Val Ala Gln Gln Ala Val Asp Ala Asp Val His Ala Val Gly Ile Ser 
            660                 665                 670         


Thr Leu Ala Ala Gly His Lys Thr Leu Val Pro Glu Leu Ile Lys Glu 
        675                 680                 685             


Leu Asn Ser Leu Gly Arg Pro Asp Ile Leu Val Met Cys Gly Gly Val 
    690                 695                 700                 


Ile Pro Pro Gln Asp Tyr Glu Phe Leu Phe Glu Val Gly Val Ser Asn 
705                 710                 715                 720 


Val Phe Gly Pro Gly Thr Arg Ile Pro Lys Ala Ala Val Gln Val Leu 
                725                 730                 735     


Asp Asp Ile Glu Lys Cys Leu Glu Lys Lys Gln Gln Ser Val 
            740                 745                 750 


<210>  213
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MCM I671V

<400>  213

Met Leu Arg Ala Lys Asn Gln Leu Phe Leu Leu Ser Pro His Tyr Leu 
1               5                   10                  15      


Arg Gln Val Lys Glu Ser Ser Gly Ser Arg Leu Ile Gln Gln Arg Leu 
            20                  25                  30          


Leu His Gln Gln Gln Pro Leu His Pro Glu Trp Ala Ala Leu Ala Lys 
        35                  40                  45              


Lys Gln Leu Lys Gly Lys Asn Pro Glu Asp Leu Ile Trp His Thr Pro 
    50                  55                  60                  


Glu Gly Ile Ser Ile Lys Pro Leu Tyr Ser Lys Arg Asp Thr Met Asp 
65                  70                  75                  80  


Leu Pro Glu Glu Leu Pro Gly Val Lys Pro Phe Thr Arg Gly Pro Tyr 
                85                  90                  95      


Pro Thr Met Tyr Thr Phe Arg Pro Trp Thr Ile Arg Gln Tyr Ala Gly 
            100                 105                 110         


Phe Ser Thr Val Glu Glu Ser Asn Lys Phe Tyr Lys Asp Asn Ile Lys 
        115                 120                 125             


Ala Gly Gln Gln Gly Leu Ser Val Ala Phe Asp Leu Ala Thr His Arg 
    130                 135                 140                 


Gly Tyr Asp Ser Asp Asn Pro Arg Val Arg Gly Asp Val Gly Met Ala 
145                 150                 155                 160 


Gly Val Ala Ile Asp Thr Val Glu Asp Thr Lys Ile Leu Phe Asp Gly 
                165                 170                 175     


Ile Pro Leu Glu Lys Met Ser Val Ser Met Thr Met Asn Gly Ala Val 
            180                 185                 190         


Ile Pro Val Leu Ala Asn Phe Ile Val Thr Gly Glu Glu Gln Gly Val 
        195                 200                 205             


Pro Lys Glu Lys Leu Thr Gly Thr Ile Gln Asn Asp Ile Leu Lys Glu 
    210                 215                 220                 


Phe Met Val Arg Asn Thr Tyr Ile Phe Pro Pro Glu Pro Ser Met Lys 
225                 230                 235                 240 


Ile Ile Ala Asp Ile Phe Glu Tyr Thr Ala Lys His Met Pro Lys Phe 
                245                 250                 255     


Asn Ser Ile Ser Ile Ser Gly Tyr His Met Gln Glu Ala Gly Ala Asp 
            260                 265                 270         


Ala Ile Leu Glu Leu Ala Tyr Thr Leu Ala Asp Gly Leu Glu Tyr Ser 
        275                 280                 285             


Arg Thr Gly Leu Gln Ala Gly Leu Thr Ile Asp Glu Phe Ala Pro Arg 
    290                 295                 300                 


Leu Ser Phe Phe Trp Gly Ile Gly Met Asn Phe Tyr Met Glu Ile Ala 
305                 310                 315                 320 


Lys Met Arg Ala Gly Arg Arg Leu Trp Ala His Leu Ile Glu Lys Met 
                325                 330                 335     


Phe Gln Pro Lys Asn Ser Lys Ser Leu Leu Leu Arg Ala His Cys Gln 
            340                 345                 350         


Thr Ser Gly Trp Ser Leu Thr Glu Gln Asp Pro Tyr Asn Asn Ile Val 
        355                 360                 365             


Arg Thr Ala Ile Glu Ala Met Ala Ala Val Phe Gly Gly Thr Gln Ser 
    370                 375                 380                 


Leu His Thr Asn Ser Phe Asp Glu Ala Leu Gly Leu Pro Thr Val Lys 
385                 390                 395                 400 


Ser Ala Arg Ile Ala Arg Asn Thr Gln Ile Ile Ile Gln Glu Glu Ser 
                405                 410                 415     


Gly Ile Pro Lys Val Ala Asp Pro Trp Gly Gly Ser Tyr Met Met Glu 
            420                 425                 430         


Cys Leu Thr Asn Asp Val Tyr Asp Ala Ala Leu Lys Leu Ile Asn Glu 
        435                 440                 445             


Ile Glu Glu Met Gly Gly Met Ala Lys Ala Val Ala Glu Gly Ile Pro 
    450                 455                 460                 


Lys Leu Arg Ile Glu Glu Cys Ala Ala Arg Arg Gln Ala Arg Ile Asp 
465                 470                 475                 480 


Ser Gly Ser Glu Val Ile Val Gly Val Asn Lys Tyr Gln Leu Glu Lys 
                485                 490                 495     


Glu Asp Ala Val Glu Val Leu Ala Ile Asp Asn Thr Ser Val Arg Asn 
            500                 505                 510         


Arg Gln Ile Glu Lys Leu Lys Lys Ile Lys Ser Ser Arg Asp Gln Ala 
        515                 520                 525             


Leu Ala Glu Arg Cys Leu Ala Ala Leu Thr Glu Cys Ala Ala Ser Gly 
    530                 535                 540                 


Asp Gly Asn Ile Leu Ala Leu Ala Val Asp Ala Ser Arg Ala Arg Cys 
545                 550                 555                 560 


Thr Val Gly Glu Ile Thr Asp Ala Leu Lys Lys Val Phe Gly Glu His 
                565                 570                 575     


Lys Ala Asn Asp Arg Met Val Ser Gly Ala Tyr Arg Gln Glu Phe Gly 
            580                 585                 590         


Glu Ser Lys Glu Ile Thr Ser Ala Ile Lys Arg Val His Lys Phe Met 
        595                 600                 605             


Glu Arg Glu Gly Arg Arg Pro Arg Leu Leu Val Ala Lys Met Gly Gln 
    610                 615                 620                 


Asp Gly His Asp Arg Gly Ala Lys Val Ile Ala Thr Gly Phe Ala Asp 
625                 630                 635                 640 


Leu Gly Phe Asp Val Asp Ile Gly Pro Leu Phe Gln Thr Pro Arg Glu 
                645                 650                 655     


Val Ala Gln Gln Ala Val Asp Ala Asp Val His Ala Val Gly Val Ser 
            660                 665                 670         


Thr Leu Ala Ala Gly His Lys Thr Leu Val Pro Glu Leu Ile Lys Glu 
        675                 680                 685             


Leu Asn Ser Leu Gly Arg Pro Asp Ile Leu Val Met Cys Gly Gly Val 
    690                 695                 700                 


Ile Pro Pro Gln Asp Tyr Glu Phe Leu Phe Glu Val Gly Val Ser Asn 
705                 710                 715                 720 


Val Phe Gly Pro Gly Thr Arg Ile Pro Lys Ala Ala Val Gln Val Leu 
                725                 730                 735     


Asp Asp Ile Glu Lys Cys Leu Glu Lys Lys Gln Gln Ser Val 
            740                 745                 750 


<210>  214
<211>  2250
<212>  DNA
<213>  Homo sapiens

<400>  214
atgttaagag ctaagaatca gcttttttta ctttcacctc attacctgag gcaggtaaaa       60

gaatcatcag gctccaggct catacagcaa cgacttctac accagcaaca gccccttcac      120

ccagaatggg ctgccctggc taaaaagcag ctgaaaggca aaaacccaga agacctaata      180

tggcacaccc cggaagggat ctctataaaa cccttgtatt ccaagagaga tactatggac      240

ttacctgaag aacttccagg agtgaagcca ttcacacgtg gaccatatcc taccatgtat      300

acctttaggc cctggaccat ccgccagtat gctggtttta gtactgtgga agaaagcaat      360

aagttctata aggacaacat taaggctggt cagcagggat tatcagttgc ctttgatctg      420

gcgacacatc gtggctatga ttcagacaac cctcgagttc gtggtgatgt tggaatggct      480

ggagttgcta ttgacactgt ggaagatacc aaaattcttt ttgatggaat tcctttagaa      540

aaaatgtcag tttccatgac tatgaatgga gcagttattc cagttcttgc aaattttata      600

gtaactggag aagaacaagg tgtacctaaa gagaagctta ctggtaccat ccaaaatgat      660

atactaaagg aatttatggt tcgaaataca tacatttttc ctccagaacc atccatgaaa      720

attattgctg acatatttga atatacagca aagcacatgc caaaatttaa ttcaatttca      780

attagtggat accatatgca ggaagcaggg gctgatgcca ttctggagct ggcctatact      840

ttagcagatg gattggagta ctctagaact ggactccagg ctggcctgac aattgatgaa      900

tttgcaccaa ggttgtcttt cttctgggga attggaatga atttctatat ggaaatagca      960

aagatgagag ctggtagaag actctgggct cacttaatag agaaaatgtt tcagcctaaa     1020

aactcaaaat ctcttcttct aagagcacac tgtcagacat ctggatggtc acttactgag     1080

caggatccct acaataatat tgtccgtact gcaatagaag caatggcagc agtatttgga     1140

gggactcagt ctttgcacac aaattctttt gatgaagctt tgggtttgcc aactgtgaaa     1200

agtgctcgaa ttgccaggaa cacacaaatc atcattcaag aagaatctgg gattcccaaa     1260

gtggctgatc cttggggagg ttcttacatg atggaatgtc tcacaaatga tgtttatgat     1320

gctgctttaa agctcattaa tgaaattgaa gaaatgggtg gaatggccaa agctgtagct     1380

gagggaatac ctaaacttcg aattgaagaa tgtgctgccc gaagacaagc tagaatagat     1440

tctggttctg aagtaattgt tggagtaaat aagtaccagt tggaaaaaga agacgctgta     1500

gaagttctgg caattgataa tacttcagtg cgaaacaggc agattgaaaa acttaagaag     1560

atcaaatcca gcagggatca agctttggct gaacgttgtc ttgctgcact aaccgaatgt     1620

gctgctagcg gagatggaaa tatcctggct cttgcagtgg atgcatctcg ggcaagatgt     1680

acagtgggag aaatcacaga tgccctgaaa aaggtatttg gtgaacataa agcgaatgat     1740

cgaatggtga gtggagcata tcgccaggaa tttggagaaa gtaaagagat aacatctgct     1800

atcaagaggg ttcataaatt catggaacgt gaaggtcgca gacctcgtct tcttgtagca     1860

aaaatgggac aagatggcca tgacagagga gcaaaagtta ttgctacagg atttgctgat     1920

cttggttttg atgtggacat aggccctctt ttccagactc ctcgtgaagt ggcccagcag     1980

gctgtggatg cggatgtgca tgctgtgggc ataagcaccc tcgctgctgg tcataaaacc     2040

ctagttcctg aactcatcaa agaacttaac tcccttggac ggccagatat tcttgtcatg     2100

tgtggagggg tgataccacc tcaggattat gaatttctgt ttgaagttgg tgtttccaat     2160

gtatttggtc ctgggactcg aattccaaag gctgccgttc aggtgcttga tgatattgag     2220

aagtgtttgg aaaagaagca gcaatctgta                                      2250


<210>  215
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-001 Upstream UTR

<400>  215
gggaaataag agagaaaaga agagtaagaa gaaatataag agccacc                     47


<210>  216
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-002 Upstream UTR

<400>  216
gggagatcag agagaaaaga agagtaagaa gaaatataag agccacc                     47


<210>  217
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-003 Upstream UTR

<400>  217
ggaataaaag tctcaacaca acatatacaa aacaaacgaa tctcaagcaa tcaagcattc       60

tacttctatt gcagcaattt aaatcatttc ttttaaagca aaagcaattt tctgaaaatt      120

ttcaccattt acgaacgata gcaac                                            145


<210>  218
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  5UTR-004 Upstream UTR

<400>  218
gggagacaag cuuggcauuc cgguacuguu gguaaagcca cc                          42


<210>  219
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-005 Upstream UTR

<400>  219
gggagatcag agagaaaaga agagtaagaa gaaatataag agccacc                     47


<210>  220
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-006 Upstream UTR

<400>  220
ggaataaaag tctcaacaca acatatacaa aacaaacgaa tctcaagcaa tcaagcattc       60

tacttctatt gcagcaattt aaatcatttc ttttaaagca aaagcaattt tctgaaaatt      120

ttcaccattt acgaacgata gcaac                                            145


<210>  221
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  5UTR-007 Upstream UTR

<400>  221
gggagacaag cuuggcauuc cgguacuguu gguaaagcca cc                          42


<210>  222
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-008 Upstream UTR

<400>  222
gggaattaac agagaaaaga agagtaagaa gaaatataag agccacc                     47


<210>  223
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-009 Upstream UTR

<400>  223
gggaaattag acagaaaaga agagtaagaa gaaatataag agccacc                     47


<210>  224
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-010 Upstream UTR

<400>  224
gggaaataag agagtaaaga acagtaagaa gaaatataag agccacc                     47


<210>  225
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-011 Upstream UTR

<400>  225
gggaaaaaag agagaaaaga agactaagaa gaaatataag agccacc                     47


<210>  226
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-012 Upstream UTR

<400>  226
gggaaataag agagaaaaga agagtaagaa gatatataag agccacc                     47


<210>  227
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-013 Upstream UTR

<400>  227
gggaaataag agacaaaaca agagtaagaa gaaatataag agccacc                     47


<210>  228
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-014 Upstream UTR

<400>  228
gggaaattag agagtaaaga acagtaagta gaattaaaag agccacc                     47


<210>  229
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-015 Upstream UTR

<400>  229
gggaaataag agagaataga agagtaagaa gaaatataag agccacc                     47


<210>  230
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-016 Upstream UTR

<400>  230
gggaaataag agagaaaaga agagtaagaa gaaaattaag agccacc                     47


<210>  231
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-017 Upstream UTR

<400>  231
gggaaataag agagaaaaga agagtaagaa gaaatttaag agccacc                     47


<210>  232
<211>  371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-001 Creatine Kinase

<400>  232
gcgcctgccc acctgccacc gactgctgga acccagccag tgggagggcc tggcccacca       60

gagtcctgct ccctcactcc tcgccccgcc ccctgtccca gagtcccacc tgggggctct      120

ctccaccctt ctcagagttc cagtttcaac cagagttcca accaatgggc tccatcctct      180

ggattctggc caatgaaata tctccctggc agggtcctct tcttttccca gagctccacc      240

ccaaccagga gctctagtta atggagagct cccagcacac tcggagcttg tgctttgtct      300

ccacgcaaag cgataaataa aagcattggt ggcctttggt ctttgaataa agcctgagta      360

ggaagtctag a                                                           371


<210>  233
<211>  568
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-002 Myoglobin

<400>  233
gcccctgccg ctcccacccc cacccatctg ggccccgggt tcaagagaga gcggggtctg       60

atctcgtgta gccatataga gtttgcttct gagtgtctgc tttgtttagt agaggtgggc      120

aggaggagct gaggggctgg ggctggggtg ttgaagttgg ctttgcatgc ccagcgatgc      180

gcctccctgt gggatgtcat caccctggga accgggagtg gcccttggct cactgtgttc      240

tgcatggttt ggatctgaat taattgtcct ttcttctaaa tcccaaccga acttcttcca      300

acctccaaac tggctgtaac cccaaatcca agccattaac tacacctgac agtagcaatt      360

gtctgattaa tcactggccc cttgaagaca gcagaatgtc cctttgcaat gaggaggaga      420

tctgggctgg gcgggccagc tggggaagca tttgactatc tggaacttgt gtgtgcctcc      480

tcaggtatgg cagtgactca cctggtttta ataaaacaac ctgcaacatc tcatggtctt      540

tgaataaagc ctgagtagga agtctaga                                         568


<210>  234
<211>  289
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-003 alpha-actin

<400>  234
acacactcca cctccagcac gcgacttctc aggacgacga atcttctcaa tgggggggcg       60

gctgagctcc agccaccccg cagtcacttt ctttgtaaca acttccgttg ctgccatcgt      120

aaactgacac agtgtttata acgtgtacat acattaactt attacctcat tttgttattt      180

ttcgaaacaa agccctgtgg aagaaaatgg aaaacttgaa gaagcattaa agtcattctg      240

ttaagctgcg taaatggtct ttgaataaag cctgagtagg aagtctaga                  289


<210>  235
<211>  379
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-004 Albumin

<400>  235
catcacattt aaaagcatct cagcctacca tgagaataag agaaagaaaa tgaagatcaa       60

aagcttattc atctgttttt ctttttcgtt ggtgtaaagc caacaccctg tctaaaaaac      120

ataaatttct ttaatcattt tgcctctttt ctctgtgctt caattaataa aaaatggaaa      180

gaatctaata gagtggtaca gcactgttat ttttcaaaga tgtgttgcta tcctgaaaat      240

tctgtaggtt ctgtggaagt tccagtgttc tctcttattc cacttcggta gaggatttct      300

agtttcttgt gggctaatta aataaatcat taatactctt ctaatggtct ttgaataaag      360

cctgagtagg aagtctaga                                                   379


<210>  236
<211>  118
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-005 alpha-globin

<400>  236
gctgccttct gcggggcttg ccttctggcc atgcccttct tctctccctt gcacctgtac       60

ctcttggtct ttgaataaag cctgagtagg aaggcggccg ctcgagcatg catctaga        118


<210>  237
<211>  908
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-006 G-CSF

<400>  237
gccaagccct ccccatccca tgtatttatc tctatttaat atttatgtct atttaagcct       60

catatttaaa gacagggaag agcagaacgg agccccaggc ctctgtgtcc ttccctgcat      120

ttctgagttt cattctcctg cctgtagcag tgagaaaaag ctcctgtcct cccatcccct      180

ggactgggag gtagataggt aaataccaag tatttattac tatgactgct ccccagccct      240

ggctctgcaa tgggcactgg gatgagccgc tgtgagcccc tggtcctgag ggtccccacc      300

tgggaccctt gagagtatca ggtctcccac gtgggagaca agaaatccct gtttaatatt      360

taaacagcag tgttccccat ctgggtcctt gcacccctca ctctggcctc agccgactgc      420

acagcggccc ctgcatcccc ttggctgtga ggcccctgga caagcagagg tggccagagc      480

tgggaggcat ggccctgggg tcccacgaat ttgctgggga atctcgtttt tcttcttaag      540

acttttggga catggtttga ctcccgaaca tcaccgacgc gtctcctgtt tttctgggtg      600

gcctcgggac acctgccctg cccccacgag ggtcaggact gtgactcttt ttagggccag      660

gcaggtgcct ggacatttgc cttgctggac ggggactggg gatgtgggag ggagcagaca      720

ggaggaatca tgtcaggcct gtgtgtgaaa ggaagctcca ctgtcaccct ccacctcttc      780

accccccact caccagtgtc ccctccactg tcacattgta actgaacttc aggataataa      840

agtgtttgcc tccatggtct ttgaataaag cctgagtagg aaggcggccg ctcgagcatg      900

catctaga                                                               908


<210>  238
<211>  835
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-007 Col1a2; collagen, type I, alpha 2

<400>  238
actcaatcta aattaaaaaa gaaagaaatt tgaaaaaact ttctctttgc catttcttct       60

tcttcttttt taactgaaag ctgaatcctt ccatttcttc tgcacatcta cttgcttaaa      120

ttgtgggcaa aagagaaaaa gaaggattga tcagagcatt gtgcaataca gtttcattaa      180

ctccttcccc cgctccccca aaaatttgaa tttttttttc aacactctta cacctgttat      240

ggaaaatgtc aacctttgta agaaaaccaa aataaaaatt gaaaaataaa aaccataaac      300

atttgcacca cttgtggctt ttgaatatct tccacagagg gaagtttaaa acccaaactt      360

ccaaaggttt aaactacctc aaaacacttt cccatgagtg tgatccacat tgttaggtgc      420

tgacctagac agagatgaac tgaggtcctt gttttgtttt gttcataata caaaggtgct      480

aattaatagt atttcagata cttgaagaat gttgatggtg ctagaagaat ttgagaagaa      540

atactcctgt attgagttgt atcgtgtggt gtatttttta aaaaatttga tttagcattc      600

atattttcca tcttattccc aattaaaagt atgcagatta tttgcccaaa tcttcttcag      660

attcagcatt tgttctttgc cagtctcatt ttcatcttct tccatggttc cacagaagct      720

ttgtttcttg ggcaagcaga aaaattaaat tgtacctatt ttgtatatgt gagatgttta      780

aataaattgt gaaaaaaatg aaataaagca tgtttggttt tccaaaagaa catat           835


<210>  239
<211>  297
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-008 Col6a2; collagen, type VI, alpha 2

<400>  239
cgccgccgcc cgggccccgc agtcgagggt cgtgagccca ccccgtccat ggtgctaagc       60

gggcccgggt cccacacggc cagcaccgct gctcactcgg acgacgccct gggcctgcac      120

ctctccagct cctcccacgg ggtccccgta gccccggccc ccgcccagcc ccaggtctcc      180

ccaggccctc cgcaggctgc ccggcctccc tccccctgca gccatcccaa ggctcctgac      240

ctacctggcc cctgagctct ggagcaagcc ctgacccaat aaaggctttg aacccat         297


<210>  240
<211>  602
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-009 RPN1; ribophorin I

<400>  240
ggggctagag ccctctccgc acagcgtgga gacggggcaa ggaggggggt tattaggatt       60

ggtggttttg ttttgctttg tttaaagccg tgggaaaatg gcacaacttt acctctgtgg      120

gagatgcaac actgagagcc aaggggtggg agttgggata atttttatat aaaagaagtt      180

tttccacttt gaattgctaa aagtggcatt tttcctatgt gcagtcactc ctctcatttc      240

taaaataggg acgtggccag gcacggtggc tcatgcctgt aatcccagca ctttgggagg      300

ccgaggcagg cggctcacga ggtcaggaga tcgagactat cctggctaac acggtaaaac      360

cctgtctcta ctaaaagtac aaaaaattag ctgggcgtgg tggtgggcac ctgtagtccc      420

agctactcgg gaggctgagg caggagaaag gcatgaatcc aagaggcaga gcttgcagtg      480

agctgagatc acgccattgc actccagcct gggcaacagt gttaagactc tgtctcaaat      540

ataaataaat aaataaataa ataaataaat aaataaaaat aaagcgagat gttgccctca      600

aa                                                                     602


<210>  241
<211>  785
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-010 LRP1; low density lipoprotein receptor-related protein 1

<400>  241
ggccctgccc cgtcggactg cccccagaaa gcctcctgcc ccctgccagt gaagtccttc       60

agtgagcccc tccccagcca gcccttccct ggccccgccg gatgtataaa tgtaaaaatg      120

aaggaattac attttatatg tgagcgagca agccggcaag cgagcacagt attatttctc      180

catcccctcc ctgcctgctc cttggcaccc ccatgctgcc ttcagggaga caggcaggga      240

gggcttgggg ctgcacctcc taccctccca ccagaacgca ccccactggg agagctggtg      300

gtgcagcctt cccctccctg tataagacac tttgccaagg ctctcccctc tcgccccatc      360

cctgcttgcc cgctcccaca gcttcctgag ggctaattct gggaagggag agttctttgc      420

tgcccctgtc tggaagacgt ggctctgggt gaggtaggcg ggaaaggatg gagtgtttta      480

gttcttgggg gaggccaccc caaaccccag ccccaactcc aggggcacct atgagatggc      540

catgctcaac ccccctccca gacaggccct ccctgtctcc agggccccca ccgaggttcc      600

cagggctgga gacttcctct ggtaaacatt cctccagcct cccctcccct ggggacgcca      660

aggaggtggg ccacacccag gaagggaaag cgggcagccc cgttttgggg acgtgaacgt      720

tttaataatt tttgctgaat tcctttacaa ctaaataaca cagatattgt tataaataaa      780

attgt                                                                  785


<210>  242
<211>  3001
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-011 Nnt1; cardiotrophin-like cytokine factor 1

<400>  242
atattaagga tcaagctgtt agctaataat gccacctctg cagttttggg aacaggcaaa       60

taaagtatca gtatacatgg tgatgtacat ctgtagcaaa gctcttggag aaaatgaaga      120

ctgaagaaag caaagcaaaa actgtataga gagatttttc aaaagcagta atccctcaat      180

tttaaaaaag gattgaaaat tctaaatgtc tttctgtgca tattttttgt gttaggaatc      240

aaaagtattt tataaaagga gaaagaacag cctcatttta gatgtagtcc tgttggattt      300

tttatgcctc ctcagtaacc agaaatgttt taaaaaacta agtgtttagg atttcaagac      360

aacattatac atggctctga aatatctgac acaatgtaaa cattgcaggc acctgcattt      420

tatgtttttt ttttcaacaa atgtgactaa tttgaaactt ttatgaactt ctgagctgtc      480

cccttgcaat tcaaccgcag tttgaattaa tcatatcaaa tcagttttaa ttttttaaat      540

tgtacttcag agtctatatt tcaagggcac attttctcac tactatttta atacattaaa      600

ggactaaata atctttcaga gatgctggaa acaaatcatt tgctttatat gtttcattag      660

aataccaatg aaacatacaa cttgaaaatt agtaatagta tttttgaaga tcccatttct      720

aattggagat ctctttaatt tcgatcaact tataatgtgt agtactatat taagtgcact      780

tgagtggaat tcaacatttg actaataaaa tgagttcatc atgttggcaa gtgatgtggc      840

aattatctct ggtgacaaaa gagtaaaatc aaatatttct gcctgttaca aatatcaagg      900

aagacctgct actatgaaat agatgacatt aatctgtctt cactgtttat aatacggatg      960

gatttttttt caaatcagtg tgtgttttga ggtcttatgt aattgatgac atttgagaga     1020

aatggtggct ttttttagct acctctttgt tcatttaagc accagtaaag atcatgtctt     1080

tttatagaag tgtagatttt ctttgtgact ttgctatcgt gcctaaagct ctaaatatag     1140

gtgaatgtgt gatgaatact cagattattt gtctctctat ataattagtt tggtactaag     1200

tttctcaaaa aattattaac acatgaaaga caatctctaa accagaaaaa gaagtagtac     1260

aaattttgtt actgtaatgc tcgcgtttag tgagtttaaa acacacagta tcttttggtt     1320

ttataatcag tttctatttt gctgtgcctg agattaagat ctgtgtatgt gtgtgtgtgt     1380

gtgtgtgcgt ttgtgtgtta aagcagaaaa gactttttta aaagttttaa gtgataaatg     1440

caatttgtta attgatctta gatcactagt aaactcaggg ctgaattata ccatgtatat     1500

tctattagaa gaaagtaaac accatcttta ttcctgccct ttttcttctc tcaaagtagt     1560

tgtagttata tctagaaaga agcaattttg atttcttgaa aaggtagttc ctgcactcag     1620

tttaaactaa aaataatcat acttggattt tatttatttt tgtcatagta aaaattttaa     1680

tttatatata tttttattta gtattatctt attctttgct atttgccaat cctttgtcat     1740

caattgtgtt aaatgaattg aaaattcatg ccctgttcat tttattttac tttattggtt     1800

aggatattta aaggattttt gtatatataa tttcttaaat taatattcca aaaggttagt     1860

ggacttagat tataaattat ggcaaaaatc taaaaacaac aaaaatgatt tttatacatt     1920

ctatttcatt attcctcttt ttccaataag tcatacaatt ggtagatatg acttatttta     1980

tttttgtatt attcactata tctttatgat atttaagtat aaataattaa aaaaatttat     2040

tgtaccttat agtctgtcac caaaaaaaaa aaattatctg taggtagtga aatgctaatg     2100

ttgatttgtc tttaagggct tgttaactat cctttatttt ctcatttgtc ttaaattagg     2160

agtttgtgtt taaattactc atctaagcaa aaaatgtata taaatcccat tactgggtat     2220

atacccaaag gattataaat catgctgcta taaagacaca tgcacacgta tgtttattgc     2280

agcactattc acaatagcaa agacttggaa ccaacccaaa tgtccatcaa tgatagactt     2340

gattaagaaa atgtgcacat atacaccatg gaatactatg cagccataaa aaaggatgag     2400

ttcatgtcct ttgtagggac atggataaag ctggaaacca tcattctgag caaactattg     2460

caaggacaga aaaccaaaca ctgcatgttc tcactcatag gtgggaattg aacaatgaga     2520

acacttggac acaaggtggg gaacaccaca caccagggcc tgtcatgggg tggggggagt     2580

ggggagggat agcattagga gatataccta atgtaaatga tgagttaatg ggtgcagcac     2640

accaacatgg cacatgtata catatgtagc aaacctgcac gttgtgcaca tgtaccctag     2700

aacttaaagt ataattaaaa aaaaaaagaa aacagaagct atttataaag aagttatttg     2760

ctgaaataaa tgtgatcttt cccattaaaa aaataaagaa attttggggt aaaaaaacac     2820

aatatattgt attcttgaaa aattctaaga gagtggatgt gaagtgttct caccacaaaa     2880

gtgataacta attgaggtaa tgcacatatt aattagaaag attttgtcat tccacaatgt     2940

atatatactt aaaaatatgt tatacacaat aaatacatac attaaaaaat aagtaaatgt     3000

a                                                                     3001


<210>  243
<211>  1037
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-012 Col6a1; collagen, type VI, alpha 1

<400>  243
cccaccctgc acgccggcac caaaccctgt cctcccaccc ctccccactc atcactaaac       60

agagtaaaat gtgatgcgaa ttttcccgac caacctgatt cgctagattt tttttaagga      120

aaagcttgga aagccaggac acaacgctgc tgcctgcttt gtgcagggtc ctccggggct      180

cagccctgag ttggcatcac ctgcgcaggg ccctctgggg ctcagccctg agctagtgtc      240

acctgcacag ggccctctga ggctcagccc tgagctggcg tcacctgtgc agggccctct      300

ggggctcagc cctgagctgg cctcacctgg gttccccacc ccgggctctc ctgccctgcc      360

ctcctgcccg ccctccctcc tgcctgcgca gctccttccc taggcacctc tgtgctgcat      420

cccaccagcc tgagcaagac gccctctcgg ggcctgtgcc gcactagcct ccctctcctc      480

tgtccccata gctggttttt cccaccaatc ctcacctaac agttacttta caattaaact      540

caaagcaagc tcttctcctc agcttggggc agccattggc ctctgtctcg ttttgggaaa      600

ccaaggtcag gaggccgttg cagacataaa tctcggcgac tcggccccgt ctcctgaggg      660

tcctgctggt gaccggcctg gaccttggcc ctacagccct ggaggccgct gctgaccagc      720

actgaccccg acctcagaga gtactcgcag gggcgctggc tgcactcaag accctcgaga      780

ttaacggtgc taaccccgtc tgctcctccc tcccgcagag actggggcct ggactggaca      840

tgagagcccc ttggtgccac agagggctgt gtcttactag aaacaacgca aacctctcct      900

tcctcagaat agtgatgtgt tcgacgtttt atcaaaggcc ccctttctat gttcatgtta      960

gttttgctcc ttctgtgttt ttttctgaac catatccatg ttgctgactt ttccaaataa     1020

aggttttcac tcctctc                                                    1037


<210>  244
<211>  577
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-013 Calr; calreticulin

<400>  244
agaggcctgc ctccagggct ggactgaggc ctgagcgctc ctgccgcaga gctggccgcg       60

ccaaataatg tctctgtgag actcgagaac tttcattttt ttccaggctg gttcggattt      120

ggggtggatt ttggttttgt tcccctcctc cactctcccc caccccctcc ccgccctttt      180

tttttttttt ttttaaactg gtattttatc tttgattctc cttcagccct cacccctggt      240

tctcatcttt cttgatcaac atcttttctt gcctctgtcc ccttctctca tctcttagct      300

cccctccaac ctggggggca gtggtgtgga gaagccacag gcctgagatt tcatctgctc      360

tccttcctgg agcccagagg agggcagcag aagggggtgg tgtctccaac cccccagcac      420

tgaggaagaa cggggctctt ctcatttcac ccctcccttt ctcccctgcc cccaggactg      480

ggccacttct gggtggggca gtgggtccca gattggctca cactgagaat gtaagaacta      540

caaacaaaat ttctattaaa ttaaattttg tgtctcc                               577


<210>  245
<211>  2212
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-014 Col1a1; collagen, type I, alpha 1

<400>  245
ctccctccat cccaacctgg ctccctccca cccaaccaac tttcccccca acccggaaac       60

agacaagcaa cccaaactga accccctcaa aagccaaaaa atgggagaca atttcacatg      120

gactttggaa aatatttttt tcctttgcat tcatctctca aacttagttt ttatctttga      180

ccaaccgaac atgaccaaaa accaaaagtg cattcaacct taccaaaaaa aaaaaaaaaa      240

aaagaataaa taaataactt tttaaaaaag gaagcttggt ccacttgctt gaagacccat      300

gcgggggtaa gtccctttct gcccgttggg cttatgaaac cccaatgctg ccctttctgc      360

tcctttctcc acacccccct tggggcctcc cctccactcc ttcccaaatc tgtctcccca      420

gaagacacag gaaacaatgt attgtctgcc cagcaatcaa aggcaatgct caaacaccca      480

agtggccccc accctcagcc cgctcctgcc cgcccagcac ccccaggccc tgggggacct      540

ggggttctca gactgccaaa gaagccttgc catctggcgc tcccatggct cttgcaacat      600

ctccccttcg tttttgaggg ggtcatgccg ggggagccac cagcccctca ctgggttcgg      660

aggagagtca ggaagggcca cgacaaagca gaaacatcgg atttggggaa cgcgtgtcaa      720

tcccttgtgc cgcagggctg ggcgggagag actgttctgt tccttgtgta actgtgttgc      780

tgaaagacta cctcgttctt gtcttgatgt gtcaccgggg caactgcctg ggggcgggga      840

tgggggcagg gtggaagcgg ctccccattt tataccaaag gtgctacatc tatgtgatgg      900

gtggggtggg gagggaatca ctggtgctat agaaattgag atgccccccc aggccagcaa      960

atgttccttt ttgttcaaag tctattttta ttccttgata tttttctttt tttttttttt     1020

tttttgtgga tggggacttg tgaatttttc taaaggtgct atttaacatg ggaggagagc     1080

gtgtgcggct ccagcccagc ccgctgctca ctttccaccc tctctccacc tgcctctggc     1140

ttctcaggcc tctgctctcc gacctctctc ctctgaaacc ctcctccaca gctgcagccc     1200

atcctcccgg ctccctccta gtctgtcctg cgtcctctgt ccccgggttt cagagacaac     1260

ttcccaaagc acaaagcagt ttttccccct aggggtggga ggaagcaaaa gactctgtac     1320

ctattttgta tgtgtataat aatttgagat gtttttaatt attttgattg ctggaataaa     1380

gcatgtggaa atgacccaaa cataatccgc agtggcctcc taatttcctt ctttggagtt     1440

gggggagggg tagacatggg gaaggggctt tggggtgatg ggcttgcctt ccattcctgc     1500

cctttccctc cccactattc tcttctagat ccctccataa ccccactccc ctttctctca     1560

cccttcttat accgcaaacc tttctacttc ctctttcatt ttctattctt gcaatttcct     1620

tgcacctttt ccaaatcctc ttctcccctg caataccata caggcaatcc acgtgcacaa     1680

cacacacaca cactcttcac atctggggtt gtccaaacct catacccact ccccttcaag     1740

cccatccact ctccaccccc tggatgccct gcacttggtg gcggtgggat gctcatggat     1800

actgggaggg tgaggggagt ggaacccgtg aggaggacct gggggcctct ccttgaactg     1860

acatgaaggg tcatctggcc tctgctccct tctcacccac gctgacctcc tgccgaagga     1920

gcaacgcaac aggagagggg tctgctgagc ctggcgaggg tctgggaggg accaggagga     1980

aggcgtgctc cctgctcgct gtcctggccc tgggggagtg agggagacag acacctggga     2040

gagctgtggg gaaggcactc gcaccgtgct cttgggaagg aaggagacct ggccctgctc     2100

accacggact gggtgcctcg acctcctgaa tccccagaac acaacccccc tgggctgggg     2160

tggtctgggg aaccatcgtg cccccgcctc ccgcctactc ctttttaagc tt             2212


<210>  246
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-015 Plod1; procollagen-lysine, 2-oxoglutarate 5-dioxygenase 
       1

<400>  246
ttggccaggc ctgaccctct tggacctttc ttctttgccg acaaccactg cccagcagcc       60

tctgggacct cggggtccca gggaacccag tccagcctcc tggctgttga cttcccattg      120

ctcttggagc caccaatcaa agagattcaa agagattcct gcaggccaga ggcggaacac      180

acctttatgg ctggggctct ccgtggtgtt ctggacccag cccctggaga caccattcac      240

ttttactgct ttgtagtgac tcgtgctctc caacctgtct tcctgaaaaa ccaaggcccc      300

cttcccccac ctcttccatg gggtgagact tgagcagaac aggggcttcc ccaagttgcc      360

cagaaagact gtctgggtga gaagccatgg ccagagcttc tcccaggcac aggtgttgca      420

ccagggactt ctgcttcaag ttttggggta aagacacctg gatcagactc caagggctgc      480

cctgagtctg ggacttctgc ctccatggct ggtcatgaga gcaaaccgta gtcccctgga      540

gacagcgact ccagagaacc tcttgggaga cagaagaggc atctgtgcac agctcgatct      600

tctacttgcc tgtggggagg ggagtgacag gtccacacac cacactgggt caccctgtcc      660

tggatgcctc tgaagagagg gacagaccgt cagaaactgg agagtttcta ttaaaggtca      720

tttaaacca                                                              729


<210>  247
<211>  847
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-016 Nucb1; nucleobindin 1

<400>  247
tcctccggga ccccagccct caggattcct gatgctccaa ggcgactgat gggcgctgga       60

tgaagtggca cagtcagctt ccctgggggc tggtgtcatg ttgggctcct ggggcggggg      120

cacggcctgg catttcacgc attgctgcca ccccaggtcc acctgtctcc actttcacag      180

cctccaagtc tgtggctctt cccttctgtc ctccgagggg cttgccttct ctcgtgtcca      240

gtgaggtgct cagtgatcgg cttaacttag agaagcccgc cccctcccct tctccgtctg      300

tcccaagagg gtctgctctg agcctgcgtt cctaggtggc tcggcctcag ctgcctgggt      360

tgtggccgcc ctagcatcct gtatgcccac agctactgga atccccgctg ctgctccggg      420

ccaagcttct ggttgattaa tgagggcatg gggtggtccc tcaagacctt cccctacctt      480

ttgtggaacc agtgatgcct caaagacagt gtcccctcca cagctgggtg ccaggggcag      540

gggatcctca gtatagccgg tgaaccctga taccaggagc ctgggcctcc ctgaacccct      600

ggcttccagc catctcatcg ccagcctcct cctggacctc ttggccccca gccccttccc      660

cacacagccc cagaagggtc ccagagctga ccccactcca ggacctaggc ccagcccctc      720

agcctcatct ggagcccctg aagaccagtc ccacccacct ttctggcctc atctgacact      780

gctccgcatc ctgctgtgtg tcctgttcca tgttccggtt ccatccaaat acactttctg      840

gaacaaa                                                                847


<210>  248
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-017 alpha-globin

<400>  248
gctggagcct cggtggccat gcttcttgcc ccttgggcct ccccccagcc cctcctcccc       60

ttcctgcacc cgtacccccg tggtctttga ataaagtctg agtgggcggc                 110


<210>  249
<211>  2461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide sequence encoding human MCM

<400>  249
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatgttaag agctaagaat cagctttttt      120

tactttcacc tcattacctg aggcaggtaa aagaatcatc aggctccagg ctcatacagc      180

aacgacttct acaccagcaa cagccccttc acccagaatg ggctgccctg gctaaaaagc      240

agctgaaagg caaaaaccca gaagacctaa tatggcacac cccggaaggg atctctataa      300

aacccttgta ttccaagaga gatactatgg acttacctga agaacttcca ggagtgaagc      360

cattcacacg tggaccatat cctaccatgt atacctttag gccctggacc atccgccagt      420

atgctggttt tagtactgtg gaagaaagca ataagttcta taaggacaac attaaggctg      480

gtcagcaggg attatcagtt gcctttgatc tggcgacaca tcgtggctat gattcagaca      540

accctcgagt tcgtggtgat gttggaatgg ctggagttgc tattgacact gtggaagata      600

ccaaaattct ttttgatgga attcctttag aaaaaatgtc agtttccatg actatgaatg      660

gagcagttat tccagttctt gcaaatttta tagtaactgg agaagaacaa ggtgtaccta      720

aagagaagct tactggtacc atccaaaatg atatactaaa ggaatttatg gttcgaaata      780

catacatttt tcctccagaa ccatccatga aaattattgc tgacatattt gaatatacag      840

caaagcacat gccaaaattt aattcaattt caattagtgg ataccatatg caggaagcag      900

gggctgatgc cattctggag ctggcctata ctttagcaga tggattggag tactccagaa      960

ctggactcca ggctggcctg acaattgatg aatttgcacc aaggttgtct ttcttctggg     1020

gaattggaat gaatttctat atggaaatag caaagatgag agctggtaga agactctggg     1080

ctcacttaat agagaaaatg tttcagccta aaaactcaaa atctcttctt ctaagagcac     1140

actgtcagac atctggatgg tcacttactg agcaggatcc ctacaataat attgtccgta     1200

ctgcaataga agcaatggca gcagtatttg gagggactca gtctttgcac acaaattctt     1260

ttgatgaagc tttgggtttg ccaactgtga aaagtgctcg aattgccagg aacacacaaa     1320

tcatcattca agaagaatct gggattccca aagtggctga tccttgggga ggttcttaca     1380

tgatggaatg tctcacaaat gatgtttatg atgctgcttt aaagctcatt aatgaaattg     1440

aagaaatggg tggaatggcc aaagctgtag ctgagggaat acctaaactt cgaattgaag     1500

aatgtgctgc ccgaagacaa gctagaatag attctggttc tgaagtaatt gttggagtaa     1560

ataagtacca gttggaaaaa gaagacgctg tagaagttct ggcaattgat aatacttcag     1620

tgcgaaacag gcagattgaa aaacttaaga agatcaaatc cagcagggat caagctttgg     1680

ctgaacgttg tcttgctgca ctaaccgaat gtgctgctag cggagatgga aatatcctgg     1740

ctcttgcagt ggatgcatct cgggcaagat gtacagtggg agaaatcaca gatgccctga     1800

aaaaggtatt tggtgaacat aaagcgaatg atcgaatggt gagtggagca tatcgccagg     1860

aatttggaga aagtaaagag ataacatctg ctatcaagag ggttcataaa ttcatggaac     1920

gtgaaggtcg cagacctcgt cttcttgtag caaaaatggg acaagatggc catgacagag     1980

gagcaaaagt tattgctaca ggatttgctg atcttggttt tgatgtggac ataggccctc     2040

ttttccagac tcctcgtgaa gtggcccagc aggctgtgga tgcggatgtg catgctgtgg     2100

gcgtaagcac cctcgctgct ggtcataaaa ccctagttcc tgaactcatc aaagaactta     2160

actcccttgg acggccagat attcttgtca tgtgtggagg ggtgatacca cctcaggatt     2220

atgaatttct gtttgaagtt ggtgtttcca atgtatttgg tcctgggact cgaattccaa     2280

aggctgccgt tcaggtgctt gatgatattg agaagtgttt ggaaaagaag cagcaatctg     2340

tatgataata ggctggagcc tcggtggcca tgcttcttgc cccttgggcc tccccccagc     2400

ccctcctccc cttcctgcac ccgtaccccc gtggtctttg aataaagtct gagtgggcgg     2460

c                                                                     2461


<210>  250
<211>  2455
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide sequence encoding mouse MCM

<400>  250
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatgttgag agctaagaat caactttttt      120

tgctatcgcc ccattacctg aagcagctaa acattccatc agcttccaga tggaaacgcc      180

ttctacacca gcagcaaccc cttcacccag aatgggctgt actggccaaa aagcagctga      240

aaggcaaaaa cccagaggac cttatatggc acaccccaga agggatctct ataaagcccc      300

tatattccag ggcagatact ctggacttac ccgaagaact tccaggagtg aagccattca      360

cacggggacc atatcctacc atgtatacct ataggccctg gaccatccgt cagtatgcag      420

gctttagtac tgtggaagaa agcaataaat tctataagga caatattaag gctggtcagc      480

aggggttgtc tgttgccttt gacttggcaa cacatcgtgg ttatgattca gacaacccca      540

gagttcgtgg agatgttgga atggctggag ttgctattga cactgtagaa gacaccaaaa      600

tcctatttga tggcattcct ttagaaaaaa tgtccgtttc catgactatg aacggagctg      660

tcatcccagt cctggcaaca tttatagtaa ctggggaaga gcaaggtgtg ccgaaggaga      720

agctcactgg cacaattcag aatgacatcc taaaggagtt tatggtcaga aatacttata      780

tttttccccc agagccatcg atgaaaatta ttgctgacat tttccaatac acagcacagc      840

acatgccaaa atttaattcc atttcgatta gcgggtacca tatgcaggaa gcaggagctg      900

atgccatttt agaactggcc tataccatcg cagatgggtt ggagtactgc agaactggac      960

tccaggctgg actcacaatt gatgaatttg caccaaggtt gtctttcttc tggggaattg     1020

gaatgaactt ctacatggaa atagccaaga tgcgagctgg gagaagactg tgggctcact     1080

taatagaaaa aatgttccag cctaaaaact ctaaatctct tcttctaaga gcacactgcc     1140

agacatcggg gtggtcactt actgagcagg atccttacaa taacattgtc cgcactgcaa     1200

tcgaagccat ggcagctgtg tttggaggaa cccagtcttt gcatacgaac tcttttgatg     1260

aagcgctggg tttgcccact gtgaaaagtg cccggattgc tcggaacaca cagatcatca     1320

ttcaggaaga atctgggatc cccaaagtgg cggatccttg gggagggtcg tacatgatgg     1380

agtcgctcac aaatgacgtt tatgaggctg ctctgaagtt gatatatgaa gttgaagaaa     1440

tgggtggaat ggccaaagct gtagctgaag gaatccctaa acttcgcatt gaagaatgtg     1500

ctgcccgaag acaagctaga atagattctg gttctgaggt aattgttgga gtaaataagt     1560

atcagttgga aaaagaagac tctgtggagg tcctggccat tgacaacact tcagtgcgta     1620

agaagcagat tgaaaaactc aagaagatta aatccagcag ggatcaagct ttggctgagc     1680

agtgtctcag tgcacttacc cagtgtgctg ccagtggaga tggcaatatt ctggctctgg     1740

cagtggatgc agctcgtgca agatgtacag ttggagaaat cacggatgcc ttgaaaaaag     1800

tatttggtga gcataaagct aatgatcgta tggtgagtgg agcatatcgg caggagtttg     1860

gagaaagtaa agagatcaca tctgccatca agagagttaa taaattcatg gaacgtgaag     1920

gtcgcagacc tcgtcttctt gtggcaaaaa tgggacaaga tggccatgac aggggagcca     1980

aggtcattgc tacaggattt gctgatcttg gttttgatgt ggacataggc cctctttttc     2040

agactccccg tgaagtggcg cagcaagctg tggatgcaga tgtccatgct gtgggtgtca     2100

gcacacttgc tgctggtcat aaaaccctcg ttcctgagct tatcaaagaa ctcaccgccc     2160

tggggcggcc agatatcctt gtcatgtgtg ggggcgtgat tccaccacag gattatgaat     2220

ttctgtatga agttggtgtt tccaacgtct ttggtcctgg aacccggatt ccaagagctg     2280

ctgtccaagt gcttgatgat attgagaagt gtttggcaga gaagcagcag tctgtgtgat     2340

aataggctgg agcctcggtg gccatgcttc ttgccccttg ggcctccccc cagcccctcc     2400

tccccttcct gcacccgtac ccccgtggtc tttgaataaa gtctgagtgg gcggc          2455


<210>  251
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mitochondrial targeting peptides

<400>  251

Met Leu Ser Leu Arg Gln Ser Ile Arg Phe Phe Lys Pro Ala Thr Arg 
1               5                   10                  15      


Thr Leu Cys Ser Ser Arg Tyr Leu Leu 
            20                  25  


<210>  252
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mitochondrial targeting peptides

<400>  252

Met Ala Leu Leu Arg Gly Val Phe Val Val Ala Ala Lys Arg Thr Pro 
1               5                   10                  15      


<210>  253
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mitochondrial targeting peptides

<400>  253

Met Leu Arg Ile Pro Val Arg Lys Ala Leu Val Gly Leu Ser Lys Ser 
1               5                   10                  15      


Ser Lys Gly Cys Val Arg Thr 
            20              


<210>  254
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mitochondrial targeting peptide

<400>  254

Met Arg Gln Pro Ala Val Arg Leu Val Arg Leu Gly Arg Val Pro Tyr 
1               5                   10                  15      


Ala Glu Leu Leu Gly Leu Gln Asp Arg Trp Leu Arg Arg Leu Gln 
            20                  25                  30      


<210>  255
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mitochondrial targeting peptides

<400>  255

Met Glu Thr Trp Arg Lys Gly Ser Phe Arg Asn 
1               5                   10      


<210>  256
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mitochondrial targeting peptides

<400>  256

Met Ala Ala Leu Arg Arg Met Leu His Leu Pro Ser Leu Met Met Gly 
1               5                   10                  15      


Thr Cys Arg Pro Phe Ala Gly Ser Leu Ala Asp Ser 
            20                  25              


<210>  257
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mitochondrial targeting peptides

<400>  257

Met Leu Leu Trp Pro Leu Arg Gly Trp Ala Ala Arg Ala Leu Arg Cys 
1               5                   10                  15      


Phe Gly Pro Gly Ser Arg Gly Ser Pro Ala Ser Gly Pro Gly Pro Arg 
            20                  25                  30          


Arg 
    


<210>  258
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mitochondrial targeting peptides

<400>  258

Met Arg Cys Leu Thr Thr Pro Met Leu Leu Arg Ala Leu Ala Gln Ala 
1               5                   10                  15      


Ala Arg Ala Gly Pro Pro Gly Gly Arg Ser Leu His Ser Ser Ala Val 
            20                  25                  30          


Ala Ala 
        


<210>  259
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mitochondrial targeting peptides

<400>  259

Met Ala Ala Ser Trp Arg Leu Gly Cys Asp Pro Arg Leu Leu Arg Tyr 
1               5                   10                  15      


Leu Val Gly Phe Pro Gly Arg Arg Ser Val Gly Leu Val Lys Gly Ala 
            20                  25                  30          


Leu Gly Trp Ser Val Ser Arg Gly Ala Asn Trp Arg Trp Phe His Ser 
        35                  40                  45              


Thr Gln Trp Leu Arg 
    50              


<210>  260
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mitochondrial targeting peptides

<400>  260

Met Ser Ala Leu Cys Trp Gly Arg Gly Ala Ala Gly Leu Lys Arg Ala 
1               5                   10                  15      


Leu Arg Pro Cys Gly Arg Pro Gly Leu Pro Gly Lys Glu Gly Thr Ala 
            20                  25                  30          


Gly Gly Val Cys Gly Pro Arg Arg Ser 
        35                  40      


<210>  261
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mitochondrial targeting peptides

<400>  261

Met Gly Gly Leu Phe Trp Arg Ser Ala Leu Arg Gly Leu Arg Cys Gly 
1               5                   10                  15      


Pro Arg Ala Pro Gly Pro Ser Leu Leu Val Arg His Gly Ser Gly Gly 
            20                  25                  30          


Pro 
    


<210>  262
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mitochondrial targeting peptides

<400>  262

Met Ala Val Leu Trp Arg Leu Ser Ala Val Cys Gly Ala Leu Gly Gly 
1               5                   10                  15      


Arg Ala Leu Leu Leu Arg Thr Pro Val Val Arg Pro Ala His Ile Ser 
            20                  25                  30          


Ala Phe Leu Gln Asp Arg Pro Ile Pro Glu Trp Cys Gly Val Gln His 
        35                  40                  45              


Ile His Leu Ser Pro Ser His His 
    50                  55      


<210>  263
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mitochondrial targeting peptides

<400>  263

Met Tyr Tyr Lys Phe Ser Gly Phe Thr Gln Lys Leu Ala Gly Ala Trp 
1               5                   10                  15      


Ala Ser Glu Ala Tyr Ser Pro Gln Gly Leu Lys Pro Val Val Ser Thr 
            20                  25                  30          


Glu Ala Pro Pro Ile Ile Phe Ala Thr Pro Thr Lys Leu Thr Ser Asp 
        35                  40                  45              


Ser Thr Val Tyr Asp Tyr Ala 
    50                  55  


<210>  264
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse methylmalonyl-CoA mutase

<400>  264

Met Leu Arg Ala Lys Asn Gln Leu Phe Leu Leu Ser Pro His Tyr Leu 
1               5                   10                  15      


Lys Gln Leu Asn Ile Pro Ser Ala Ser Arg Trp Lys Arg Leu 
            20                  25                  30  


<210>  265
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human methylmalonyl-CoA mutase

<400>  265

Met Leu Arg Ala Lys Asn Gln Leu Phe Leu Leu Ser Pro His Tyr Leu 
1               5                   10                  15      


Arg Gln Val Lys Glu Ser Ser Gly Ser Arg Leu Ile Gln Gln Arg Leu 
            20                  25                  30          


<210>  266
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5UTR-018 Upstream UTR

<400>  266
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca cc                                     92


<210>  267
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3UTR-018

<400>  267
tgataatagg ctggagcctc ggtggccatg cttcttgccc cttgggcctc cccccagccc       60

ctcctcccct tcctgcaccc gtacccccgt ggtctttgaa taaagtctga gtgggcggc       119


<210>  268
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mouse MCM

<400>  268

Met Leu Arg Ala Lys Asn Gln Leu Phe Leu Leu Ser Pro His Tyr Leu 
1               5                   10                  15      


Lys Gln Leu Asn Ile Pro Ser Ala Ser Arg Trp Lys Arg Leu Leu His 
            20                  25                  30          


Gln Gln Gln Pro Leu His Pro Glu Trp Ala Val Leu Ala Lys Lys Gln 
        35                  40                  45              


Leu Lys Gly Lys Asn Pro Glu Asp Leu Ile Trp His Thr Pro Glu Gly 
    50                  55                  60                  


Ile Ser Ile Lys Pro Leu Tyr Ser Arg Ala Asp Thr Leu Asp Leu Pro 
65                  70                  75                  80  


Glu Glu Leu Pro Gly Val Lys Pro Phe Thr Arg Gly Pro Tyr Pro Thr 
                85                  90                  95      


Met Tyr Thr Tyr Arg Pro Trp Thr Ile Arg Gln Tyr Ala Gly Phe Ser 
            100                 105                 110         


Thr Val Glu Glu Ser Asn Lys Phe Tyr Lys Asp Asn Ile Lys Ala Gly 
        115                 120                 125             


Gln Gln Gly Leu Ser Val Ala Phe Asp Leu Ala Thr His Arg Gly Tyr 
    130                 135                 140                 


Asp Ser Asp Asn Pro Arg Val Arg Gly Asp Val Gly Met Ala Gly Val 
145                 150                 155                 160 


Ala Ile Asp Thr Val Glu Asp Thr Lys Ile Leu Phe Asp Gly Ile Pro 
                165                 170                 175     


Leu Glu Lys Met Ser Val Ser Met Thr Met Asn Gly Ala Val Ile Pro 
            180                 185                 190         


Val Leu Ala Thr Phe Ile Val Thr Gly Glu Glu Gln Gly Val Pro Lys 
        195                 200                 205             


Glu Lys Leu Thr Gly Thr Ile Gln Asn Asp Ile Leu Lys Glu Phe Met 
    210                 215                 220                 


Val Arg Asn Thr Tyr Ile Phe Pro Pro Glu Pro Ser Met Lys Ile Ile 
225                 230                 235                 240 


Ala Asp Ile Phe Gln Tyr Thr Ala Gln His Met Pro Lys Phe Asn Ser 
                245                 250                 255     


Ile Ser Ile Ser Gly Tyr His Met Gln Glu Ala Gly Ala Asp Ala Ile 
            260                 265                 270         


Leu Glu Leu Ala Tyr Thr Ile Ala Asp Gly Leu Glu Tyr Cys Arg Thr 
        275                 280                 285             


Gly Leu Gln Ala Gly Leu Thr Ile Asp Glu Phe Ala Pro Arg Leu Ser 
    290                 295                 300                 


Phe Phe Trp Gly Ile Gly Met Asn Phe Tyr Met Glu Ile Ala Lys Met 
305                 310                 315                 320 


Arg Ala Gly Arg Arg Leu Trp Ala His Leu Ile Glu Lys Met Phe Gln 
                325                 330                 335     


Pro Lys Asn Ser Lys Ser Leu Leu Leu Arg Ala His Cys Gln Thr Ser 
            340                 345                 350         


Gly Trp Ser Leu Thr Glu Gln Asp Pro Tyr Asn Asn Ile Val Arg Thr 
        355                 360                 365             


Ala Ile Glu Ala Met Ala Ala Val Phe Gly Gly Thr Gln Ser Leu His 
    370                 375                 380                 


Thr Asn Ser Phe Asp Glu Ala Leu Gly Leu Pro Thr Val Lys Ser Ala 
385                 390                 395                 400 


Arg Ile Ala Arg Asn Thr Gln Ile Ile Ile Gln Glu Glu Ser Gly Ile 
                405                 410                 415     


Pro Lys Val Ala Asp Pro Trp Gly Gly Ser Tyr Met Met Glu Ser Leu 
            420                 425                 430         


Thr Asn Asp Val Tyr Glu Ala Ala Leu Lys Leu Ile Tyr Glu Val Glu 
        435                 440                 445             


Glu Met Gly Gly Met Ala Lys Ala Val Ala Glu Gly Ile Pro Lys Leu 
    450                 455                 460                 


Arg Ile Glu Glu Cys Ala Ala Arg Arg Gln Ala Arg Ile Asp Ser Gly 
465                 470                 475                 480 


Ser Glu Val Ile Val Gly Val Asn Lys Tyr Gln Leu Glu Lys Glu Asp 
                485                 490                 495     


Ser Val Glu Val Leu Ala Ile Asp Asn Thr Ser Val Arg Lys Lys Gln 
            500                 505                 510         


Ile Glu Lys Leu Lys Lys Ile Lys Ser Ser Arg Asp Gln Ala Leu Ala 
        515                 520                 525             


Glu Gln Cys Leu Ser Ala Leu Thr Gln Cys Ala Ala Ser Gly Asp Gly 
    530                 535                 540                 


Asn Ile Leu Ala Leu Ala Val Asp Ala Ala Arg Ala Arg Cys Thr Val 
545                 550                 555                 560 


Gly Glu Ile Thr Asp Ala Leu Lys Lys Val Phe Gly Glu His Lys Ala 
                565                 570                 575     


Asn Asp Arg Met Val Ser Gly Ala Tyr Arg Gln Glu Phe Gly Glu Ser 
            580                 585                 590         


Lys Glu Ile Thr Ser Ala Ile Lys Arg Val Asn Lys Phe Met Glu Arg 
        595                 600                 605             


Glu Gly Arg Arg Pro Arg Leu Leu Val Ala Lys Met Gly Gln Asp Gly 
    610                 615                 620                 


His Asp Arg Gly Ala Lys Val Ile Ala Thr Gly Phe Ala Asp Leu Gly 
625                 630                 635                 640 


Phe Asp Val Asp Ile Gly Pro Leu Phe Gln Thr Pro Arg Glu Val Ala 
                645                 650                 655     


Gln Gln Ala Val Asp Ala Asp Val His Ala Val Gly Val Ser Thr Leu 
            660                 665                 670         


Ala Ala Gly His Lys Thr Leu Val Pro Glu Leu Ile Lys Glu Leu Thr 
        675                 680                 685             


Ala Leu Gly Arg Pro Asp Ile Leu Val Met Cys Gly Gly Val Ile Pro 
    690                 695                 700                 


Pro Gln Asp Tyr Glu Phe Leu Tyr Glu Val Gly Val Ser Asn Val Phe 
705                 710                 715                 720 


Gly Pro Gly Thr Arg Ile Pro Arg Ala Ala Val Gln Val Leu Asp Asp 
                725                 730                 735     


Ile Glu Lys Cys Leu Ala Glu Lys Gln Gln Ser Val 
            740                 745             


<210>  269
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFP sequence

<400>  269

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  270
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O14561 mitochondrial targeting peptide

<400>  270

Met Ala Ser Arg Val Leu Ser Ala Tyr Val Ser Arg Leu Pro Ala Ala 
1               5                   10                  15      


Phe Ala Pro Leu Pro Arg Val Arg Met Leu Ala Val Ala Arg Pro Leu 
            20                  25                  30          


Ser Thr Ala Leu Cys Ser Ala Gly Thr Gln Thr Arg Leu Gly Thr Leu 
        35                  40                  45              


Gln Pro Ala Leu Val Leu Ala Gln Val Pro Gly Arg Val Thr Gln Leu 
    50                  55                  60                  


Cys Arg Gln Tyr 
65              


<210>  271
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O14874 mitochondrial targeting peptide

<400>  271

Met Ile Leu Ala Ser Val Leu Arg Ser Gly Pro Gly Gly Gly Leu Pro 
1               5                   10                  15      


Leu Arg Pro Leu Leu Gly Pro Ala Leu Ala Leu Arg Ala Arg 
            20                  25                  30  


<210>  272
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O15091mitochondrial targeting peptide

<400>  272

Met Thr Phe Tyr Leu Phe Gly Ile Arg Ser Phe Pro Lys Leu Trp Lys 
1               5                   10                  15      


Ser Pro Tyr Leu Gly Leu Gly Pro Gly His Ser Tyr Val Ser Leu Phe 
            20                  25                  30          


Leu Ala Asp Arg Cys Gly Ile Arg Asn Gln Gln Arg Leu 
        35                  40                  45  


<210>  273
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O15235 mitochondrial targeting peptide

<400>  273

Met Ser Trp Ser Gly Leu Leu His Gly Leu Asn Thr Ser Leu Thr Cys 
1               5                   10                  15      


Gly Pro Ala Leu Val Pro Arg Leu Trp Ala Thr Cys Ser 
            20                  25                  


<210>  274
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O15382 mitochondrial targeting peptide

<400>  274

Met Ala Ala Ala Ala Leu Gly Gln Ile Trp Ala Arg Lys Leu Leu Ser 
1               5                   10                  15      


Val Pro Trp Leu Leu Cys Gly Pro Arg Arg Tyr 
            20                  25          


<210>  275
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O43181 mitochondrial targeting peptide

<400>  275

Met Ala Ala Val Ser Met Ser Val Val Leu Arg Gln Thr Leu Trp Arg 
1               5                   10                  15      


Arg Arg Ala Val Ala Val Ala Ala Leu Ser Val Ser Arg Val Pro Thr 
            20                  25                  30          


Arg Ser Leu Arg Thr Ser Thr Trp Arg Leu 
        35                  40          


<210>  276
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O43464 mitochondrial targeting peptide

<400>  276

Met Ala Ala Pro Arg Ala Gly Arg Gly Ala Gly Trp Ser Leu Arg Ala 
1               5                   10                  15      


Trp Arg Ala Leu Gly Gly Ile Arg Trp Gly Arg Arg Pro Arg Leu 
            20                  25                  30      


<210>  277
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O43572 mitochondrial targeting peptide

<400>  277

Met Arg Gly Ala Gly Pro Ser Pro Arg Gln Ser Pro Arg Thr Leu Arg 
1               5                   10                  15      


Pro Asp Pro Gly Pro Ala Met Ser Phe Phe Arg Arg 
            20                  25              


<210>  278
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O43674 mitochondrial targeting peptide

<400>  278

Met Ala Ala Met Ser Leu Leu Arg Arg Val Ser Val Thr Ala Val Ala 
1               5                   10                  15      


Ala Leu Ser Gly Arg Pro Leu Gly Thr Arg Leu Gly Phe Gly Gly Phe 
            20                  25                  30          


Leu Thr Arg Gly Phe Pro Lys Ala Ala Ala Pro Val Arg His 
        35                  40                  45      


<210>  279
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O43677  mitochondrial targeting peptide

<400>  279

Met Ala Pro Ser Ala Leu Leu Arg Pro Leu Ser Arg Leu Leu Ala Pro 
1               5                   10                  15      


Ala Arg Leu Pro Ser Gly Pro Ser Val Arg Ser 
            20                  25          


<210>  280
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O43766 mitochondrial targeting peptide

<400>  280

Met Ser Leu Arg Cys Gly Asp Ala Ala Arg Thr Leu Gly Pro Arg Val 
1               5                   10                  15      


Phe Gly Arg Tyr Phe Cys Ser Pro Val Arg Pro 
            20                  25          


<210>  281
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O43819 mitochondrial targeting peptide

<400>  281

Met Leu Leu Leu Thr Arg Ser Pro Thr Ala Trp His Arg Leu Ser Gln 
1               5                   10                  15      


Leu Lys Pro Arg Val Leu Pro Gly Thr Leu Gly Gly Gln Ala Leu His 
            20                  25                  30          


Leu Arg Ser Trp Leu Leu Ser Arg Gln 
        35                  40      


<210>  282
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O43837 mitochondrial targeting peptide

<400>  282

Met Ala Ala Leu Ser Gly Val Arg Trp Leu Thr Arg Ala Leu Val Ser 
1               5                   10                  15      


Ala Gly Asn Pro Gly Ala Trp Arg Gly Leu Ser Thr Ser Ala Ala Ala 
            20                  25                  30          


His Ala 
        


<210>  283
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O60313 mitochondrial targeting peptide

<400>  283

Met Trp Arg Leu Arg Arg Ala Ala Val Ala Cys Glu Val Cys Gln Ser 
1               5                   10                  15      


Leu Val Lys His Ser Ser Gly Ile Lys Gly Ser Leu Pro Leu Gln Lys 
            20                  25                  30          


Leu His Leu Val Ser Arg Ser Ile Tyr His Ser His His Pro Thr Leu 
        35                  40                  45              


Lys Leu Gln Arg Pro Gln Leu Arg Thr Ser Phe Gln Gln Phe Ser Ser 
    50                  55                  60                  


Leu Thr Asn Leu Pro Leu Arg Lys Leu Lys Phe Ser Pro Ile Lys Tyr 
65                  70                  75                  80  


Gly Tyr Gln Pro Arg Arg Asn 
                85          


<210>  284
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O60397 mitochondrial targeting peptide

<400>  284

Met Leu Trp Asn Leu Leu Ala Leu His Gln Ile Gly Gln Arg Thr Ile 
1               5                   10                  15      


Ser Thr Ala Ser His Arg His 
            20              


<210>  285
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O75027 mitochondrial targeting peptide

<400>  285

Met Ala Leu Leu Ala Met His Ser Trp Arg Trp Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Phe Glu Lys Arg Arg 
            20          


<210>  286
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O75208 mitochondrial targeting peptide

<400>  286

Met Ala Ala Ala Ala Val Ser Gly Ala Leu Gly Arg Ala Gly Trp Arg 
1               5                   10                  15      


Leu Leu Gln Leu Arg Cys Leu Pro Val Ala Arg Cys Arg Gln Ala Leu 
            20                  25                  30          


Val Pro Arg Ala Phe His Ala Ser Ala Val Gly Leu 
        35                  40                  


<210>  287
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O75251 mitochondrial targeting peptide

<400>  287

Met Ala Val Leu Ser Ala Pro Gly Leu Arg Gly Phe Arg Ile Leu Gly 
1               5                   10                  15      


Leu Arg Ser Ser Val Gly Pro Ala Val Gln Ala Arg Gly Val His Gln 
            20                  25                  30          


Ser Val Ala Thr Asp Gly 
        35              


<210>  288
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O75306 mitochondrial targeting peptide

<400>  288

Met Ala Ala Leu Arg Ala Leu Cys Gly Phe Arg Gly Val Ala Ala Gln 
1               5                   10                  15      


Val Leu Arg Pro Gly Ala Gly Val Arg Leu Pro Ile Gln Pro Ser Arg 
            20                  25                  30          


Gly 
    


<210>  289
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O75380 mitochondrial targeting peptide

<400>  289

Met Ala Ala Ala Met Thr Phe Cys Arg Leu Leu Asn Arg Cys Gly Glu 
1               5                   10                  15      


Ala Ala Arg Ser Leu Pro Leu Gly Ala Arg Cys Phe 
            20                  25              


<210>  290
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O75390 mitochondrial targeting peptide

<400>  290

Met Ala Leu Leu Thr Ala Ala Ala Arg Leu Leu Gly Thr Lys Asn Ala 
1               5                   10                  15      


Ser Cys Leu Val Leu Ala Ala Arg His Ala Ser 
            20                  25          


<210>  291
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O75439 mitochondrial targeting peptide

<400>  291

Met Ala Ala Ala Ala Ala Arg Val Val Leu Ser Ser Ala Ala Arg Arg 
1               5                   10                  15      


Arg Leu Trp Gly Phe Ser Glu Ser Leu Leu Ile Arg Gly Ala Ala Gly 
            20                  25                  30          


Arg Ser Leu Tyr Phe Gly Glu Asn Arg Leu Arg Ser Thr 
        35                  40                  45  


<210>  292
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O75489 mitochondrial targeting peptide

<400>  292

Met Ala Ala Ala Ala Val Ala Arg Leu Trp Trp Arg Gly Ile Leu Gly 
1               5                   10                  15      


Ala Ser Ala Leu Thr Arg Gly Thr Gly Arg Pro Ser Val Leu Leu Leu 
            20                  25                  30          


Pro Val Arg Arg 
        35      


<210>  293
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O75521 mitochondrial targeting peptide

<400>  293

Met Ala Met Ala Tyr Leu Ala Trp Arg Leu Ala Arg Arg Ser Cys Pro 
1               5                   10                  15      


Ser Ser Leu Gln Val Thr Ser Phe Pro Val Val Gln Leu His Met Asn 
            20                  25                  30          


Arg Thr Ala Met Arg Ala 
        35              


<210>  294
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O75600 mitochondrial targeting peptide

<400>  294

Met Trp Pro Gly Asn Ala Trp Arg Ala Ala Leu Phe Trp Val Pro Arg 
1               5                   10                  15      


Gly Arg Arg Ala Gln 
            20      


<210>  295
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O75616 mitochondrial targeting peptide

<400>  295

Met Ala Ala Pro Ser Trp Arg Gly Ala Arg Leu Val Gln Ser Val Leu 
1               5                   10                  15      


Arg Val Trp Gln Val Gly Pro His Val Ala Arg Glu Arg Val Ile Pro 
            20                  25                  30          


Phe Ser Ser Leu Leu Gly Phe Gln Arg Arg Cys 
        35                  40              


<210>  296
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O75879 mitochondrial targeting peptide

<400>  296

Met Ala Ala Pro Met Leu Arg Trp Gly Cys Arg Gly Arg Arg Trp Ala 
1               5                   10                  15      


Phe Ala Arg Val Asp Gly Gly Ser Cys His Arg Arg Gly Ala 
            20                  25                  30  


<210>  297
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O76031 mitochondrial targeting peptide

<400>  297

Met Pro Ser Cys Gly Ala Cys Thr Cys Gly Ala Ala Ala Val Arg Leu 
1               5                   10                  15      


Ile Thr Ser Ser Leu Ala Ser Ala Gln Arg Gly Ile Ser Gly Gly Arg 
            20                  25                  30          


Ile His Met Ser Val Leu Gly Arg Leu Gly Thr Phe Glu Thr Gln Ile 
        35                  40                  45              


Leu Gln Arg Ala Pro Leu Arg Ser 
    50                  55      


<210>  298
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O94925 mitochondrial targeting peptide

<400>  298

Met Met Arg Leu Arg Gly Ser Gly Met Leu Arg Asp Leu Leu Leu Arg 
1               5                   10                  15      


<210>  299
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O95169 mitochondrial targeting peptide

<400>  299

Met Ala Val Ala Arg Ala Gly Val Leu Gly Val Gln Trp Leu Gln Arg 
1               5                   10                  15      


Ala Ser Arg Asn Val Met Pro Leu Gly Ala Arg Thr 
            20                  25              


<210>  300
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O95178 mitochondrial targeting peptide

<400>  300

Met Ser Ala Leu Thr Arg Leu Ala Ser Phe Ala Arg Val Gly Gly Arg 
1               5                   10                  15      


Leu Phe Arg Ser Gly Cys Ala Arg Thr Ala Gly Asp Gly Gly Val Arg 
            20                  25                  30          


His 
    


<210>  301
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O95202 mitochondrial targeting peptide

<400>  301

Met Ala Ser Ile Leu Leu Arg Ser Cys Arg Gly Arg Ala Pro Ala Arg 
1               5                   10                  15      


Leu Pro Pro Pro Pro Arg Tyr Thr Val Pro Arg Gly Ser Pro Gly Asp 
            20                  25                  30          


Pro Ala His Leu Ser Cys Ala Ser Thr Leu Gly Leu Arg Asn Cys Leu 
        35                  40                  45              


Asn Val Pro Phe Gly Cys Cys Thr Pro Ile His Pro Val Tyr Thr Ser 
    50                  55                  60                  


Ser Arg Gly Asp His Leu Gly Cys Trp Ala Leu Arg Pro Glu Cys Leu 
65                  70                  75                  80  


Arg Ile Val Ser Arg Ala Pro Trp Thr Ser Thr Ser Val Gly Phe Val 
                85                  90                  95      


Ala Val Gly Pro Gln Cys Leu Pro Val Arg Gly Trp His Ser Ser Arg 
            100                 105                 110         


Pro Val Arg 
        115 


<210>  302
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O95299 mitochondrial targeting peptide

<400>  302

Met Ala Leu Arg Leu Leu Lys Leu Ala Ala Thr Ser Ala Ser Ala Arg 
1               5                   10                  15      


Val Val Ala Ala Gly Ala Gln Arg Val Arg Gly Ile His Ser Ser Val 
            20                  25                  30          


Gln Cys Lys 
        35  


<210>  303
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O95571 mitochondrial targeting peptide

<400>  303

Met Ala Glu Ala Val Leu Arg 
1               5           


<210>  304
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O95822 mitochondrial targeting peptide

<400>  304

Met Arg Gly Phe Gly Pro Gly Leu Thr Ala Arg Arg Leu Leu Pro Leu 
1               5                   10                  15      


Arg Leu Pro Pro Arg Pro Pro Gly Pro Arg Leu Ala Ser Gly Gln Ala 
            20                  25                  30          


Ala Gly Ala Leu Glu Arg Ala 
        35                  


<210>  305
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O95831 mitochondrial targeting peptide

<400>  305

Met Phe Arg Cys Gly Gly Leu Ala Ala Gly Ala Leu Lys Gln Lys Leu 
1               5                   10                  15      


Val Pro Leu Val Arg Thr Val Cys Val Arg Ser Pro Arg Gln Arg Asn 
            20                  25                  30          


Arg Leu Pro Gly Asn Leu Phe Gln Arg Trp His Val Pro Leu Glu Leu 
        35                  40                  45              


Gln Met Thr Arg Gln Met 
    50                  


<210>  306
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P00367 mitochondrial targeting peptide

<400>  306

Met Tyr Arg Tyr Leu Gly Glu Ala Leu Leu Leu Ser Arg Ala Gly Pro 
1               5                   10                  15      


Ala Ala Leu Gly Ser Ala Ser Ala Asp Ser Ala Ala Leu Leu Gly Trp 
            20                  25                  30          


Ala Arg Gly Gln Pro Ala Ala Ala Pro Gln Pro Gly Leu Ala Leu Ala 
        35                  40                  45              


Ala Arg Arg His Tyr 
    50              


<210>  307
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P00390 mitochondrial targeting peptide

<400>  307

Met Ala Leu Leu Pro Arg Ala Leu Ser Ala Gly Ala Gly Pro Ser Trp 
1               5                   10                  15      


Arg Arg Ala Ala Arg Ala Phe Arg Gly Phe Leu Leu Leu Leu Pro Glu 
            20                  25                  30          


Pro Ala Ala Leu Thr Arg Ala Leu Ser Arg Ala 
        35                  40              


<210>  308
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P00480 mitochondrial targeting peptide

<400>  308

Met Leu Phe Asn Leu Arg Ile Leu Leu Asn Asn Ala Ala Phe Arg Asn 
1               5                   10                  15      


Gly His Asn Phe Met Val Arg Asn Phe Arg Cys Gly Gln Pro Leu Gln 
            20                  25                  30          


<210>  309
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P00505 mitochondrial targeting peptide

<400>  309

Met Ala Leu Leu His Ser Gly Arg Val Leu Pro Gly Ile Ala Ala Ala 
1               5                   10                  15      


Phe His Pro Gly Leu Ala Ala Ala Ala Ser Ala Arg Ala 
            20                  25                  


<210>  310
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P04179 mitochondrial targeting peptide

<400>  310

Met Leu Ser Arg Ala Val Cys Gly Thr Ser Arg Gln Leu Ala Pro Ala 
1               5                   10                  15      


Leu Gly Tyr Leu Gly Ser Arg Gln 
            20                  


<210>  311
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P04181 (25) mitochondrial targeting peptide

<400>  311

Met Phe Ser Lys Leu Ala His Leu Gln Arg Phe Ala Val Leu Ser Arg 
1               5                   10                  15      


Gly Val His Ser Ser Val Ala Ser Ala Thr Ser Val Ala Thr Lys Lys 
            20                  25                  30          


Thr Val Gln 
        35  


<210>  312
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P04181 (35) mitochondrial targeting peptide

<400>  312

Met Phe Ser Lys Leu Ala His Leu Gln Arg Phe Ala Val Leu Ser Arg 
1               5                   10                  15      


Gly Val His Ser Ser Val Ala Ser Ala 
            20                  25  


<210>  313
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P05091 mitochondrial targeting peptide

<400>  313

Met Leu Arg Ala Ala Ala Arg Phe Gly Pro Arg Leu Gly Arg Arg Leu 
1               5                   10                  15      


Leu 
    


<210>  314
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P05108 mitochondrial targeting peptide

<400>  314

Met Leu Ala Lys Gly Leu Pro Pro Arg Ser Val Leu Val Lys Gly Cys 
1               5                   10                  15      


Gln Thr Phe Leu Ser Ala Pro Arg Glu Gly Leu Gly Arg Leu Arg Val 
            20                  25                  30          


Pro Thr Gly Glu Gly Ala Gly 
        35                  


<210>  315
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P05165 mitochondrial targeting peptide

<400>  315

Met Ala Gly Phe Trp Val Gly Thr Ala Pro Leu Val Ala Ala Gly Arg 
1               5                   10                  15      


Arg Gly Arg Trp Pro Pro Gln Gln Leu Met Leu Ser Ala Ala Leu Arg 
            20                  25                  30          


Thr Leu Lys His Val Leu Tyr Tyr Ser Arg Gln Cys Leu Met Val Ser 
        35                  40                  45              


Arg Asn Leu Gly 
    50          


<210>  316
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P05166 mitochondrial targeting peptide

<400>  316

Met Ala Ala Ala Leu Arg Val Ala Ala Val Gly Ala Arg Leu Ser Val 
1               5                   10                  15      


Leu Ala Ser Gly Leu Arg Ala Ala Val Arg Ser Leu 
            20                  25              


<210>  317
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P05496 mitochondrial targeting peptide

<400>  317

Met Gln Thr Ala Gly Ala Leu Phe Ile Ser Pro Ala Leu Ile Arg Cys 
1               5                   10                  15      


Cys Thr Arg Gly Leu Ile Arg Pro Val Ser Ala Ser Phe Leu Asn Ser 
            20                  25                  30          


Pro Val Asn Ser Ser Lys Gln Pro Ser Tyr Ser Asn Phe Pro Leu Gln 
        35                  40                  45              


Val Ala Arg Arg Glu Phe Gln Thr Ser Val Val Ser Arg 
    50                  55                  60      


<210>  318
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P06576 mitochondrial targeting peptide

<400>  318

Met Leu Gly Phe Val Gly Arg Val Ala Ala Ala Pro Ala Ser Gly Ala 
1               5                   10                  15      


Leu Arg Arg Leu Thr Pro Ser Ala Ser Leu Pro Pro Ala Gln Leu Leu 
            20                  25                  30          


Leu Arg Ala Ala Pro Thr Ala Val His Pro Val Arg Asp Tyr Ala 
        35                  40                  45          


<210>  319
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P07919 mitochondrial targeting peptide

<400>  319

Met Gly Leu Glu Asp Glu Gln Lys Met Leu Thr Glu Ser 
1               5                   10              


<210>  320
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P07954 mitochondrial targeting peptide

<400>  320

Met Tyr Arg Ala Leu Arg Leu Leu Ala Arg Ser Arg Pro Leu Val Arg 
1               5                   10                  15      


Ala Pro Ala Ala Ala Leu Ala Ser Ala Pro Gly Leu Gly Gly Ala Ala 
            20                  25                  30          


Val Pro Ser Phe Trp Pro Pro Asn Ala Ala Arg Met 
        35                  40                  


<210>  321
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P08559 mitochondrial targeting peptide

<400>  321

Met Arg Lys Met Leu Ala Ala Val Ser Arg Val Leu Ser Gly Ala Ser 
1               5                   10                  15      


Gln Lys Pro Ala Ser Arg Val Leu Val Ala Ser Arg Asn Phe 
            20                  25                  30  


<210>  322
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P08574 mitochondrial targeting peptide

<400>  322

Met Ala Ala Ala Ala Ala Ser Leu Arg Gly Val Val Leu Gly Pro Arg 
1               5                   10                  15      


Gly Ala Gly Leu Pro Gly Ala Arg Ala Arg Gly Leu Leu Cys Ser Ala 
            20                  25                  30          


Arg Pro Gly Gln Leu Pro Leu Arg Thr Pro Gln Ala Val Ala Leu Ser 
        35                  40                  45              


Ser Lys Ser Gly Leu Ser Arg Gly Arg Lys Val Met Leu Ser Ala Leu 
    50                  55                  60                  


Gly Met Leu Ala Ala Gly Gly Ala Gly Leu Ala Met Ala Leu His Ser 
65                  70                  75                  80  


Ala Val Ser Ala 
                


<210>  323
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P09622 mitochondrial targeting peptide

<400>  323

Met Gln Ser Trp Ser Arg Val Tyr Cys Ser Leu Ala Lys Arg Gly His 
1               5                   10                  15      


Phe Asn Arg Ile Ser His Gly Leu Gln Gly Leu Ser Ala Val Pro Leu 
            20                  25                  30          


Arg Thr Tyr 
        35  


<210>  324
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P0C7M7 mitochondrial targeting peptide

<400>  324

Met Lys Ile Phe Phe Arg Tyr Gln Thr Phe Arg Phe Ile Trp Leu Thr 
1               5                   10                  15      


Lys Pro Pro Gly Arg Arg 
            20          


<210>  325
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P0C7P0 mitochondrial targeting peptide

<400>  325

Met Arg Gly Ala Gly Ala Ile Leu Arg Pro Ala Ala Arg Gly 
1               5                   10                  


<210>  326
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P10109 mitochondrial targeting peptide

<400>  326

Met Ala Ala Ala Gly Gly Ala Arg Leu Leu Arg Ala Ala Ser Ala Val 
1               5                   10                  15      


Leu Gly Gly Pro Ala Gly Arg Trp Leu His His Ala Gly Ser Arg Ala 
            20                  25                  30          


Gly Ser Ser Gly Leu Leu Arg Asn Arg Gly Pro Gly Gly Ser Ala Glu 
        35                  40                  45              


Ala Ser Arg Ser Leu Ser Val Ser Ala Arg Ala Arg 
    50                  55                  60  


<210>  327
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P10176 mitochondrial targeting peptide

<400>  327

Met Ser Val Leu Thr Pro Leu Leu Leu Arg Gly Leu Thr Gly Ser Ala 
1               5                   10                  15      


Arg Arg Leu Pro Val Pro Arg Ala Lys 
            20                  25  


<210>  328
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P10515 mitochondrial targeting peptide

<400>  328

Met Trp Arg Val Cys Ala Arg Arg Ala Gln Asn Val Ala Pro Trp Ala 
1               5                   10                  15      


Gly Leu Glu Ala Arg Trp Thr Ala Leu Gln Glu Val Pro Gly Thr Pro 
            20                  25                  30          


Arg Val Thr Ser Arg Ser Gly Pro Ala Pro Ala Arg Arg Asn Ser Val 
        35                  40                  45              


Thr Thr Gly Tyr Gly Gly Val Arg Ala Leu Cys Gly Trp Thr Pro Ser 
    50                  55                  60                  


Ser Gly Ala Thr Pro Arg Asn Arg Leu Leu Leu Gln Leu Leu Gly Ser 
65                  70                  75                  80  


Pro Gly Arg Arg Tyr Tyr 
                85      


<210>  329
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P10606 mitochondrial targeting peptide

<400>  329

Met Ala Ser Arg Leu Leu Arg Gly Ala Gly Thr Leu Ala Ala Gln Ala 
1               5                   10                  15      


Leu Arg Ala Arg Gly Pro Ser Gly Ala Ala Ala Met Arg Ser Met 
            20                  25                  30      


<210>  330
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P10809 mitochondrial targeting peptide

<400>  330

Met Leu Arg Leu Pro Thr Val Phe Arg Gln Met Arg Pro Val Ser Arg 
1               5                   10                  15      


Val Leu Ala Pro His Leu Thr Arg Ala Tyr 
            20                  25      


<210>  331
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P11177 mitochondrial targeting peptide

<400>  331

Met Ala Ala Val Ser Gly Leu Val Arg Arg Pro Leu Arg Glu Val Ser 
1               5                   10                  15      


Gly Leu Leu Lys Arg Arg Phe His Trp Thr Ala Pro Ala Ala 
            20                  25                  30  


<210>  332
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P11182 mitochondrial targeting peptide

<400>  332

Met Ala Ala Val Arg Met Leu Arg Thr Trp Ser Arg Asn Ala Gly Lys 
1               5                   10                  15      


Leu Ile Cys Val Arg Tyr Phe Gln Thr Cys Gly Asn Val His Val Leu 
            20                  25                  30          


Lys Pro Asn Tyr Val Cys Phe Phe Gly Tyr Pro Ser Phe Lys Tyr Ser 
        35                  40                  45              


His Pro His His Phe Leu Lys Thr Thr Ala Ala Leu Arg 
    50                  55                  60      


<210>  333
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P11310 mitochondrial targeting peptide

<400>  333

Met Ala Ala Gly Phe Gly Arg Cys Cys Arg Val Leu Arg Ser Ile Ser 
1               5                   10                  15      


Arg Phe His Trp Arg Ser Gln His Thr 
            20                  25  


<210>  334
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P11498 mitochondrial targeting peptide

<400>  334

Met Leu Lys Phe Arg Thr Val His Gly Gly Leu Arg Leu Leu Gly Ile 
1               5                   10                  15      


Arg Arg Thr Ser 
            20  


<210>  335
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P12074 mitochondrial targeting peptide

<400>  335

Met Ala Val Val Gly Val Ser Ser Val Ser Arg Leu Leu Gly Arg Ser 
1               5                   10                  15      


Arg Pro Gln Leu Gly Arg Pro Met 
            20                  


<210>  336
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P12532 mitochondrial targeting peptide

<400>  336

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Arg 
1               5                   10                  15      


Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Phe Leu Leu 
            20                  25                  30          


Arg Pro Glu Pro Val Arg Ala 
        35                  


<210>  337
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P12694 mitochondrial targeting peptide

<400>  337

Met Ala Val Ala Ile Ala Ala Ala Arg Val Trp Arg Leu Asn Arg Gly 
1               5                   10                  15      


Leu Ser Gln Ala Ala Leu Leu Leu Leu Arg Gln Pro Gly Ala Arg Gly 
            20                  25                  30          


Leu Ala Arg Ser His Pro Pro Arg Gln Gln Gln Gln Phe 
        35                  40                  45  


<210>  338
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P13073 mitochondrial targeting peptide

<400>  338

Met Leu Ala Thr Arg Val Phe Ser Leu Val Gly Lys Arg Ala Ile Ser 
1               5                   10                  15      


Thr Ser Val Cys Val Arg 
            20          


<210>  339
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P13196 mitochondrial targeting peptide

<400>  339

Met Glu Ser Val Val Arg Arg Cys Pro Phe Leu Ser Arg Val Pro Gln 
1               5                   10                  15      


Ala Phe Leu Gln Lys Ala Gly Lys Ser Leu Leu Phe Tyr Ala Gln Asn 
            20                  25                  30          


Cys Pro Lys Met Met Glu Val Gly Ala Lys Pro Ala Pro Arg Ala Leu 
        35                  40                  45              


Ser Thr Ala Ala Val His Tyr Gln 
    50                  55      


<210>  340
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P13804 mitochondrial targeting peptide

<400>  340

Met Phe Arg Ala Ala Ala Pro Gly Gln Leu Arg Arg Ala Ala Ser Leu 
1               5                   10                  15      


Leu Arg Phe 
            


<210>  341
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P13995 mitochondrial targeting peptide

<400>  341

Met Ala Ala Thr Ser Leu Met Ser Ala Leu Ala Ala Arg Leu Leu Gln 
1               5                   10                  15      


Pro Ala His Ser Cys Ser Leu Arg Leu Arg Pro Phe His Leu Ala Ala 
            20                  25                  30          


Val Arg Asn 
        35  


<210>  342
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P14406 mitochondrial targeting peptide

<400>  342

Met Leu Arg Asn Leu Leu Ala Leu Arg Gln Ile Gly Gln Arg Thr Ile 
1               5                   10                  15      


Ser Thr Ala Ser Arg Arg His 
            20              


<210>  343
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P15538 mitochondrial targeting peptide

<400>  343

Met Ala Leu Arg Ala Lys Ala Glu Val Cys Met Ala Val Pro Trp Leu 
1               5                   10                  15      


Ser Leu Gln Arg Ala Gln Ala Leu 
            20                  


<210>  344
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P15954 mitochondrial targeting peptide

<400>  344

Met Leu Gly Gln Ser Ile Arg Arg Phe Thr Thr Ser Val Val Arg Arg 
1               5                   10                  15      


<210>  345
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P16219 mitochondrial targeting peptide

<400>  345

Met Ala Ala Ala Leu Leu Ala Arg Ala Ser Gly Pro Ala Arg Arg Ala 
1               5                   10                  15      


Leu Cys Pro Arg Ala Trp Arg Gln 
            20                  


<210>  346
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P17540 mitochondrial targeting peptide

<400>  346

Met Ala Ser Ile Phe Ser Lys Leu Leu Thr Gly Arg Asn Ala Ser Leu 
1               5                   10                  15      


Leu Phe Ala Thr Met Gly Thr Ser Val Leu Thr Thr Gly Tyr Leu Leu 
            20                  25                  30          


Asn Arg Gln Lys Val Cys Ala 
        35                  


<210>  347
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P18859 mitochondrial targeting peptide

<400>  347

Met Ile Leu Gln Arg Leu Phe Arg Phe Ser Ser Val Ile Arg Ser Ala 
1               5                   10                  15      


Val Ser Val His Leu Arg Arg Asn Ile Gly Val Thr Ala Val Ala Phe 
            20                  25                  30          


<210>  348
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P19099 mitochondrial targeting peptide

<400>  348

Met Ala Leu Arg Ala Lys Ala Glu Val Cys Val Ala Ala Pro Trp Leu 
1               5                   10                  15      


Ser Leu Gln Arg Ala Arg Ala Leu 
            20                  


<210>  349
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P19404 mitochondrial targeting peptide

<400>  349

Met Phe Phe Ser Ala Ala Leu Arg Ala Arg Ala Ala Gly Leu Thr Ala 
1               5                   10                  15      


His Trp Gly Arg His Val Arg Asn Leu His Lys Thr Val Met Gln Asn 
            20                  25                  30          


<210>  350
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P20674 mitochondrial targeting peptide

<400>  350

Met Leu Gly Ala Ala Leu Arg Arg Cys Ala Val Ala Ala Thr Thr Arg 
1               5                   10                  15      


Ala Asp Pro Arg Gly Leu Leu His Ser Ala Arg Thr Pro Gly Pro Ala 
            20                  25                  30          


Val Ala Ile Gln Ser Val Arg Cys Tyr 
        35                  40      


<210>  351
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P21912 mitochondrial targeting peptide

<400>  351

Met Ala Ala Val Val Ala Leu Ser Leu Arg Arg Arg Leu Pro Ala Thr 
1               5                   10                  15      


Thr Leu Gly Gly Ala Cys Leu Gln Ala Ser Arg Gly 
            20                  25              


<210>  352
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P21953 mitochondrial targeting peptide

<400>  352

Met Ala Val Val Ala Ala Ala Ala Gly Trp Leu Leu Arg Leu Arg Ala 
1               5                   10                  15      


Ala Gly Ala Glu Gly His Trp Arg Arg Leu Pro Gly Ala Gly Leu Ala 
            20                  25                  30          


Arg Gly Phe Leu His Pro Ala Ala Thr Val Glu Asp Ala Ala Gln Arg 
        35                  40                  45              


Arg Gln 
    50  


<210>  353
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P22033 mitochondrial targeting peptide

<400>  353

Met Leu Arg Ala Lys Asn Gln Leu Phe Leu Leu Ser Pro His Tyr Leu 
1               5                   10                  15      


Arg Gln Val Lys Glu Ser Ser Gly Ser Arg Leu Ile Gln Gln Arg Leu 
            20                  25                  30          


<210>  354
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P22557 mitochondrial targeting peptide

<400>  354

Met Val Thr Ala Ala Met Leu Leu Gln Cys Cys Pro Val Leu Ala Arg 
1               5                   10                  15      


Gly Pro Thr Ser Leu Leu Gly Lys Val Val Lys Thr His Gln Phe Leu 
            20                  25                  30          


Phe Gly Ile Gly Arg Cys Pro Ile Leu Ala Thr Gln Gly Pro Asn Cys 
        35                  40                  45              


Ser 
    


<210>  355
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P22570 mitochondrial targeting peptide

<400>  355

Met Ala Ser Arg Cys Trp Arg Trp Trp Gly Trp Ser Ala Trp Pro Arg 
1               5                   10                  15      


Thr Arg Leu Pro Pro Ala Gly Ser Thr Pro Ser Phe Cys His His Phe 
            20                  25                  30          


<210>  356
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P22695 mitochondrial targeting peptide

<400>  356

Met Lys Leu Leu Thr Arg Ala Gly Ser Phe Ser Arg Phe Tyr 
1               5                   10                  


<210>  357
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P22830 mitochondrial targeting peptide

<400>  357

Met Arg Ser Leu Gly Ala Asn Met Ala Ala Ala Leu Arg Ala Ala Gly 
1               5                   10                  15      


Val Leu Leu Arg Asp Pro Leu Ala Ser Ser Ser Trp Arg Val Cys Gln 
            20                  25                  30          


Pro Trp Arg Trp Lys Ser Gly Ala Ala Ala Ala Ala Val Thr Thr Glu 
        35                  40                  45              


Thr Ala Gln His Ala Gln 
    50                  


<210>  358
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P23368 mitochondrial targeting peptide

<400>  358

Met Leu Ser Arg Leu Arg Val Val Ser Thr Thr Cys Thr Leu Ala Cys 
1               5                   10                  15      


Arg His 
        


<210>  359
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P23378 mitochondrial targeting peptide

<400>  359

Met Gln Ser Cys Ala Arg Ala Trp Gly Leu Arg Leu Gly Arg Gly Val 
1               5                   10                  15      


Gly Gly Gly Arg Arg Leu Ala Gly Gly Ser Gly Pro Cys Trp Ala Pro 
            20                  25                  30          


Arg Ser Arg 
        35  


<210>  360
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P23434 mitochondrial targeting peptide

<400>  360

Met Ala Leu Arg Val Val Arg Ser Val Arg Ala Leu Leu Cys Thr Leu 
1               5                   10                  15      


Arg Ala Val Pro Ser Pro Ala Ala Pro Cys Pro Pro Arg Pro Trp Gln 
            20                  25                  30          


Leu Gly Val Gly Ala Val Arg Thr Leu Arg Thr Gly Pro Ala Leu Leu 
        35                  40                  45              


<210>  361
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P23786 mitochondrial targeting peptide

<400>  361

Met Val Pro Arg Leu Leu Leu Arg Ala Trp Pro Arg Gly Pro Ala Val 
1               5                   10                  15      


Gly Pro Gly Ala Pro Ser Arg Pro Leu 
            20                  25  


<210>  362
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P24310 mitochondrial targeting peptide

<400>  362

Met Gln Ala Leu Arg Val Ser Gln Ala Leu Ile Arg Ser Phe Ser Ser 
1               5                   10                  15      


Thr Ala Arg Asn Arg 
            20      


<210>  363
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P24311 mitochondrial targeting peptide

<400>  363

Met Phe Pro Leu Val Lys Ser Ala Leu Asn Arg Leu Gln Val Arg Ser 
1               5                   10                  15      


Ile Gln Gln Thr Met Ala Arg Gln 
            20                  


<210>  364
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P24539 mitochondrial targeting peptide

<400>  364

Met Leu Ser Arg Val Val Leu Ser Ala Ala Ala Thr Ala Ala Pro Ser 
1               5                   10                  15      


Leu Lys Asn Ala Ala Phe Leu Gly Pro Gly Val Leu Gln Ala Thr Arg 
            20                  25                  30          


Thr Phe His Thr Gly Gln Pro His Leu Val 
        35                  40          


<210>  365
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P24752 mitochondrial targeting peptide

<400>  365

Met Ala Val Leu Ala Ala Leu Leu Arg Ser Gly Ala Arg Ser Arg Ser 
1               5                   10                  15      


Pro Leu Leu Arg Arg Leu Val Gln Glu Ile Arg Tyr Val Glu Arg Ser 
            20                  25                  30          


Tyr 
    


<210>  366
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P25705 mitochondrial targeting peptide

<400>  366

Met Leu Ser Val Arg Val Ala Ala Ala Val Val Arg Ala Leu Pro Arg 
1               5                   10                  15      


Arg Ala Gly Leu Val Ser Arg Asn Ala Leu Gly Ser Ser Phe Ile Ala 
            20                  25                  30          


Ala Arg Asn Phe His Ala Ser Asn Thr His Leu 
        35                  40              


<210>  367
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P26440 mitochondrial targeting peptide

<400>  367

Met Ala Thr Ala Thr Arg Leu Leu Gly Trp Arg Val Ala Ser Trp Arg 
1               5                   10                  15      


Leu Arg Pro Pro Leu Ala Gly Phe Val Ser Gln Arg Ala 
            20                  25                  


<210>  368
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P28330 mitochondrial targeting peptide

<400>  368

Met Ala Ala Arg Leu Leu Arg Gly Ser Leu Arg Val Leu Gly Gly His 
1               5                   10                  15      


Arg Ala Pro Arg Gln Leu Pro Ala Ala Arg Cys Ser His Ser 
            20                  25                  30  


<210>  369
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P28331 mitochondrial targeting peptide

<400>  369

Met Leu Arg Ile Pro Val Arg Lys Ala Leu Val Gly Leu Ser Lys Ser 
1               5                   10                  15      


Pro Lys Gly Cys Val Arg Thr 
            20              


<210>  370
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P29372 mitochondrial targeting peptide

<400>  370

Met Val Thr Pro Ala Leu Gln Met Lys Lys Pro Lys Gln Phe Cys Arg 
1               5                   10                  15      


Arg 
    


<210>  371
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P29803 mitochondrial targeting peptide

<400>  371

Met Leu Ala Ala Phe Ile Ser Arg Val Leu Arg Arg Val Ala Gln Lys 
1               5                   10                  15      


Ser Ala Arg Arg Val Leu Val Ala Ser Arg Asn 
            20                  25          


<210>  372
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P30038 mitochondrial targeting peptide

<400>  372

Met Leu Leu Pro Ala Pro Ala Leu Arg Arg Ala Leu Leu Ser Arg Pro 
1               5                   10                  15      


Trp Thr Gly Ala Gly Leu Arg Trp 
            20                  


<210>  373
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P30042 mitochondrial targeting peptide

<400>  373

Met Ala Ala Val Arg Val Leu Val Ala Ser Arg Leu Ala Ala Ala Ser 
1               5                   10                  15      


Ala Phe Thr Ser Leu Ser Pro Gly Gly Arg Thr Pro Ser Gln Arg Ala 
            20                  25                  30          


Ala Leu His Leu Ser Val Pro Arg Pro 
        35                  40      


<210>  374
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P30044 mitochondrial targeting peptide

<400>  374

Met Gly Leu Ala Gly Val Cys Ala Leu Arg Arg Ser Ala Gly Tyr Ile 
1               5                   10                  15      


Leu Val Gly Gly Ala Gly Gly Gln Ser Ala Ala Ala Ala Ala Arg Arg 
            20                  25                  30          


Tyr Ser Glu Gly Glu Trp Ala Ser Gly Gly Val Arg Ser Phe Ser Arg 
        35                  40                  45              


Ala Ala Ala Ala 
    50          


<210>  375
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P30048 mitochondrial targeting peptide

<400>  375

Met Ala Ala Ala Val Gly Arg Leu Leu Arg Ala Ser Val Ala Arg His 
1               5                   10                  15      


Val Ser Ala Ile Pro Trp Gly Ile Ser Ala Thr Ala Ala Leu Arg Pro 
            20                  25                  30          


Ala Ala Cys Gly Arg Thr Ser Leu Thr Asn Leu Leu Cys Ser Gly Ser 
        35                  40                  45              


Ser Gln Ala Lys Leu Phe Ser Thr Ser Ser Ser Cys His Ala 
    50                  55                  60          


<210>  376
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P30049 mitochondrial targeting peptide

<400>  376

Met Leu Pro Ala Ala Leu Leu Arg Arg Pro Gly Leu Gly Arg Leu Val 
1               5                   10                  15      


Arg His Ala Arg Ala Tyr 
            20          


<210>  377
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P30084 mitochondrial targeting peptide

<400>  377

Met Ala Ala Leu Arg Val Leu Leu Ser Cys Val Arg Gly Pro Leu Arg 
1               5                   10                  15      


Pro Pro Val Arg Cys Pro Ala Trp Arg Pro Phe 
            20                  25          


<210>  378
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P30405 mitochondrial targeting peptide

<400>  378

Met Leu Ala Leu Arg Cys Gly Ser Arg Trp Leu Gly Leu Leu Ser Val 
1               5                   10                  15      


Pro Arg Ser Val Pro Leu Arg Leu Pro Ala Ala Arg Ala 
            20                  25                  


<210>  379
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P30837 mitochondrial targeting peptide

<400>  379

Met Leu Arg Phe Leu Ala Pro Arg Leu Leu Ser Leu Gln Gly Arg Thr 
1               5                   10                  15      


Ala 
    


<210>  380
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P31040 mitochondrial targeting peptide

<400>  380

Met Ser Gly Val Arg Gly Leu Ser Arg Leu Leu Ser Ala Arg Arg Leu 
1               5                   10                  15      


Ala Leu Ala Lys Ala Trp Pro Thr Val Leu Gln Thr Gly Thr Arg Gly 
            20                  25                  30          


Phe His Phe Thr Val Asp Gly Asn Lys Arg Ala 
        35                  40              


<210>  381
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P31327 mitochondrial targeting peptide

<400>  381

Met Thr Arg Ile Leu Thr Ala Phe Lys Val Val Arg Thr Leu Lys Thr 
1               5                   10                  15      


Gly Phe Gly Phe Thr Asn Val Thr Ala His Gln Lys Trp Lys Phe Ser 
            20                  25                  30          


Arg Pro Gly Ile Arg Leu 
        35              


<210>  382
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P31930 mitochondrial targeting peptide

<400>  382

Met Ala Ala Ser Val Val Cys Arg Ala Ala Thr Ala Gly Ala Gln Val 
1               5                   10                  15      


Leu Leu Arg Ala Arg Arg Ser Pro Ala Leu Leu Arg Thr Pro Ala Leu 
            20                  25                  30          


Arg Ser 
        


<210>  383
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P31937 mitochondrial targeting peptide

<400>  383

Met Ala Ala Ser Leu Arg Leu Leu Gly Ala Ala Ser Gly Leu Arg Tyr 
1               5                   10                  15      


Trp Ser Arg Arg Leu Arg Pro Ala Ala Gly Ser Phe Ala Ala Val Cys 
            20                  25                  30          


Ser Arg Ser Val 
        35      


<210>  384
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P33316 mitochondrial targeting peptide

<400>  384

Met Thr Pro Leu Cys Pro Arg Pro Ala Leu Cys Tyr His Phe Leu Thr 
1               5                   10                  15      


Ser Leu Leu Arg Ser Ala Met Gln Asn Ala Arg Gly Ala Arg Gln Arg 
            20                  25                  30          


Ala Glu Ala Ala Val Leu Ser Gly Pro Gly Pro Pro Leu Gly Arg Ala 
        35                  40                  45              


Ala Gln His Gly Ile Pro Arg Pro Leu Ser Ser Ala Gly Arg Leu Ser 
    50                  55                  60                  


Gln Gly Cys Arg Gly 
65                  


<210>  385
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P34897 mitochondrial targeting peptide

<400>  385

Met Leu Tyr Phe Ser Leu Phe Trp Ala Ala Arg Pro Leu Gln Arg Cys 
1               5                   10                  15      


Gly Gln Leu Val Arg Met Ala Ile Arg Ala Gln His Ser 
            20                  25                  


<210>  386
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P35218 mitochondrial targeting peptide

<400>  386

Met Leu Gly Arg Asn Thr Trp Lys Thr Ser Ala Phe Ser Phe Leu Val 
1               5                   10                  15      


Glu Gln Met Trp Ala Pro Leu Trp Ser Arg Ser Met Arg Pro Gly Arg 
            20                  25                  30          


Trp Cys Ser Gln Arg Ser 
        35              


<210>  387
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P35914 mitochondrial targeting peptide

<400>  387

Met Ala Ala Met Arg Lys Ala Leu Pro Arg Arg Leu Val Gly Leu Ala 
1               5                   10                  15      


Ser Leu Arg Ala Val Ser Thr Ser Ser Met Gly 
            20                  25          


<210>  388
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36542 mitochondrial targeting peptide

<400>  388

Met Phe Ser Arg Ala Gly Val Ala Gly Leu Ser Ala Trp Thr Leu Gln 
1               5                   10                  15      


Pro Gln Trp Ile Gln Val Arg Asn Met 
            20                  25  


<210>  389
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36551 mitochondrial targeting peptide

<400>  389

Met Ala Leu Gln Leu Gly Arg Leu Ser Ser Gly Pro Cys Trp Leu Val 
1               5                   10                  15      


Ala Arg Gly Gly Cys Gly Gly Pro Arg Ala Trp Ser Gln Cys Gly Gly 
            20                  25                  30          


Gly Gly Leu Arg Ala Trp Ser Gln Arg Ser Ala Ala Gly Arg Val Cys 
        35                  40                  45              


Arg Pro Pro Gly Pro Ala Gly Thr Glu Gln Ser Arg Gly Leu Gly His 
    50                  55                  60                  


Gly Ser Thr Ser Arg Gly Gly Pro Trp Val Gly Thr Gly Leu Ala Ala 
65                  70                  75                  80  


Ala Leu Ala Gly Leu Val Gly Leu Ala Thr Ala Ala Phe Gly His Val 
                85                  90                  95      


Gln Arg Ala Glu Met Leu Pro Lys Thr Ser Gly Thr Arg Ala 
            100                 105                 110 


<210>  390
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36639 mitochondrial targeting peptide

<400>  390

Met Tyr Trp Ser Asn Gln Ile Thr Arg Arg Leu Gly Glu Arg Val Gln 
1               5                   10                  15      


Gly Phe 
        


<210>  391
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36776 mitochondrial targeting peptide

<400>  391

Met Ala Ala Ser Thr Gly Tyr Val Arg Leu Trp Gly Ala Ala Arg Cys 
1               5                   10                  15      


Trp Val Leu Arg Arg Pro Met Leu Ala Ala Ala Gly Gly Arg Val Pro 
            20                  25                  30          


Thr Ala Ala Gly Ala Trp Leu Leu Arg Gly Gln Arg Thr Cys Asp Ala 
        35                  40                  45              


Ser Pro Pro Trp Ala Leu Trp Gly Arg Gly Pro Ala Ile Gly Gly Gln 
    50                  55                  60                  


Trp Arg Gly 
65          


<210>  392
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P36957 mitochondrial targeting peptide

<400>  392

Met Leu Ser Arg Ser Arg Cys Val Ser Arg Ala Phe Ser Arg Ser Leu 
1               5                   10                  15      


Ser Ala Phe Gln Lys Gly Asn Cys Pro Leu Gly Arg Arg Ser Leu Pro 
            20                  25                  30          


Gly Val Ser Leu Cys Gln Gly Pro Gly Tyr Pro Asn Ser Arg Lys Val 
        35                  40                  45              


Val Ile Asn Asn Ser Val Phe Ser Val Arg Phe Phe Arg Thr Thr Ala 
    50                  55                  60                  


Val Cys Lys 
65          


<210>  393
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P38646 mitochondrial targeting peptide

<400>  393

Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Ala Ala 
1               5                   10                  15      


Ala Ser Arg Gly Pro Thr Ala Ala Arg His Gln Asp Ser Trp Asn Gly 
            20                  25                  30          


Leu Ser His Glu Ala Phe Arg Leu Val Ser Arg Arg Asp Tyr 
        35                  40                  45      


<210>  394
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P40305 mitochondrial targeting peptide

<400>  394

Met Glu Ala Ser Ala Leu Thr Ser Ser Ala Val Thr Ser Val Ala Lys 
1               5                   10                  15      


Val Val Arg Val Ala Ser Gly Ser Ala Val Val Leu Pro Leu Ala Arg 
            20                  25                  30          


Ile 
    


<210>  395
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P40926 mitochondrial targeting peptide

<400>  395

Met Leu Ser Ala Leu Ala Arg Pro Ala Ser Ala Ala Leu Arg Arg Ser 
1               5                   10                  15      


Phe Ser Thr Ser Ala Gln Asn Asn 
            20                  


<210>  396
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P40939 mitochondrial targeting peptide

<400>  396

Met Val Ala Cys Arg Ala Ile Gly Ile Leu Ser Arg Phe Ser Ala Phe 
1               5                   10                  15      


Arg Ile Leu Arg Ser Arg Gly Tyr Ile Cys Arg Asn Phe Thr Gly Ser 
            20                  25                  30          


Ser Ala Leu Leu 
        35      


<210>  397
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P42126 mitochondrial targeting peptide

<400>  397

Met Ala Leu Val Ala Ser Val Arg Val Pro Ala Arg Val Leu Leu Arg 
1               5                   10                  15      


Ala Gly Ala Arg Leu Pro Gly Ala Ala Leu Gly Arg Thr Glu Arg Ala 
            20                  25                  30          


Ala Gly Gly Gly Asp Gly Ala Arg Arg 
        35                  40      


<210>  398
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P42704 mitochondrial targeting peptide

<400>  398

Met Ala Ala Leu Leu Arg Ser Ala Arg Trp Leu Leu Arg Ala Gly Ala 
1               5                   10                  15      


Ala Pro Arg Leu Pro Leu Ser Leu Arg Leu Leu Pro Gly Gly Pro Gly 
            20                  25                  30          


Arg Leu His Ala Ala Ser Tyr Leu Pro Ala Ala Arg Ala Gly Pro Val 
        35                  40                  45              


Ala Gly Gly Leu Leu Ser Pro Ala Arg Leu Tyr 
    50                  55                  


<210>  399
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P42765 mitochondrial targeting peptide

<400>  399

Met Ala Leu Leu Arg Gly Val Phe Val Val Ala Ala Lys Arg Thr Pro 
1               5                   10                  15      


<210>  400
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P43304 mitochondrial targeting peptide

<400>  400

Met Ala Phe Gln Lys Ala Val Lys Gly Thr Ile Leu Val Gly Gly Gly 
1               5                   10                  15      


Ala Leu Ala Thr Val Leu Gly Leu Ser Gln Phe Ala His Tyr Arg Arg 
            20                  25                  30          


Lys Gln Met Asn Leu Ala Tyr Val Lys Ala 
        35                  40          


<210>  401
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P43897 mitochondrial targeting peptide

<400>  401

Met Ser Leu Leu Arg Ser Leu Arg Val Phe Leu Val Ala Arg Thr Gly 
1               5                   10                  15      


Ser Tyr Pro Ala Gly Ser Leu Leu Arg Gln Ser Pro Gln Pro Arg His 
            20                  25                  30          


Thr Phe Tyr Ala Gly Pro Arg Leu Ser Ala Ser Ala Ser 
        35                  40                  45  


<210>  402
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P45954 mitochondrial targeting peptide

<400>  402

Met Glu Gly Leu Ala Val Arg Leu Leu Arg Gly Ser Arg Leu Leu Arg 
1               5                   10                  15      


Arg Asn Phe Leu Thr Cys Leu Ser Ser Trp Lys Ile Pro Pro His Val 
            20                  25                  30          


Ser 
    


<210>  403
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P46199 mitochondrial targeting peptide

<400>  403

Met Asn Gln Lys Leu Leu Lys Leu Glu Asn Leu Leu Arg Phe His Thr 
1               5                   10                  15      


Ile Tyr Arg Gln Leu His Ser Leu Cys Gln Arg Arg Ala 
            20                  25                  


<210>  404
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P47985 mitochondrial targeting peptide

<400>  404

Met Leu Ser Val Ala Ser Arg Ser Gly Pro Phe Ala Pro Val Leu Ser 
1               5                   10                  15      


Ala Thr Ser Arg Gly Val Ala Gly Ala Leu Arg Pro Leu Val Gln Ala 
            20                  25                  30          


Thr Val Pro Ala Thr Pro Glu Gln Pro Val Leu Asp Leu Lys Arg Pro 
        35                  40                  45              


Phe Leu Ser Arg Glu Ser Leu Ser Gly Gln Ala Val Arg Arg Pro Leu 
    50                  55                  60                  


Val Ala Ser Val Gly Leu Asn Val Pro Ala Ser Val Cys Tyr 
65                  70                  75              


<210>  405
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P48047 mitochondrial targeting peptide

<400>  405

Met Ala Ala Pro Ala Val Ser Gly Leu Ser Arg Gln Val Arg Cys Phe 
1               5                   10                  15      


Ser Thr Ser Val Val Arg Pro 
            20              


<210>  406
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P48201 mitochondrial targeting peptide

<400>  406

Met Phe Ala Cys Ala Lys Leu Ala Cys Thr Pro Ser Leu Ile Arg Ala 
1               5                   10                  15      


Gly Ser Arg Val Ala Tyr Arg Pro Ile Ser Ala Ser Val Leu Ser Arg 
            20                  25                  30          


Pro Glu Ala Ser Arg Thr Gly Glu Gly Ser Thr Val Phe Asn Gly Ala 
        35                  40                  45              


Gln Asn Gly Val Ser Gln Leu Ile Gln Arg Glu Phe Gln Thr Ser Ala 
    50                  55                  60                  


Ile Ser Arg 
65          


<210>  407
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P48728 mitochondrial targeting peptide

<400>  407

Met Gln Arg Ala Val Ser Val Val Ala Arg Leu Gly Phe Arg Leu Gln 
1               5                   10                  15      


Ala Phe Pro Pro Ala Leu Cys Arg Pro Leu Ser Cys 
            20                  25              


<210>  408
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P48735 mitochondrial targeting peptide

<400>  408

Met Ala Gly Tyr Leu Arg Val Val Arg Ser Leu Cys Arg Ala Ser Gly 
1               5                   10                  15      


Ser Arg Pro Ala Trp Ala Pro Ala Ala Leu Thr Ala Pro Thr Ser Gln 
            20                  25                  30          


Glu Gln Pro Arg Arg His Tyr 
        35                  


<210>  409
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P49411 mitochondrial targeting peptide

<400>  409

Met Ala Ala Ala Thr Leu Leu Arg Ala Thr Pro His Phe Ser Gly Leu 
1               5                   10                  15      


Ala Ala Gly Arg Thr Phe Leu Leu Gln Gly Leu Leu Arg Leu Leu Lys 
            20                  25                  30          


Ala Pro Ala Leu Pro Leu Leu Cys Arg Gly Leu 
        35                  40              


<210>  410
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P49419 mitochondrial targeting peptide

<400>  410

Met Trp Arg Leu Pro Arg Ala Leu Cys Val His Ala Ala Lys Thr Ser 
1               5                   10                  15      


Lys Leu Ser Gly Pro Trp Ser Arg Pro Ala 
            20                  25      


<210>  411
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P49448 mitochondrial targeting peptide

<400>  411

Met Tyr Arg Tyr Leu Ala Lys Ala Leu Leu Pro Ser Arg Ala Gly Pro 
1               5                   10                  15      


Ala Ala Leu Gly Ser Ala Ala Asn His Ser Ala Ala Leu Leu Gly Arg 
            20                  25                  30          


Gly Arg Gly Gln Pro Ala Ala Ala Ser Gln Pro Gly Leu Ala Leu Ala 
        35                  40                  45              


Ala Arg Arg His Tyr 
    50              


<210>  412
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P49590 mitochondrial targeting peptide

<400>  412

Met Pro Leu Leu Gly Leu Leu Pro Arg Arg Ala Trp Ala Ser Leu Leu 
1               5                   10                  15      


Ser Gln Leu Leu Arg Pro Pro Cys Ala Ser Cys Thr Gly Ala Val Arg 
            20                  25                  30          


Cys 
    


<210>  413
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P49675 mitochondrial targeting peptide

<400>  413

Met Leu Leu Ala Thr Phe Lys Leu Cys Ala Gly Ser Ser Tyr Arg His 
1               5                   10                  15      


Met Arg Asn Met Lys Gly Leu Arg Gln Gln Ala Val Met Ala Ile Ser 
            20                  25                  30          


Gln Glu Leu Asn Arg Arg Ala Leu Gly Gly Pro Thr Pro Ser Thr Trp 
        35                  40                  45              


Ile Asn Gln Val Arg Arg Arg Ser Ser Leu Leu Gly Ser Arg Leu 
    50                  55                  60              


<210>  414
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P49748 mitochondrial targeting peptide

<400>  414

Met Gln Ala Ala Arg Met Ala Ala Ser Leu Gly Arg Gln Leu Leu Arg 
1               5                   10                  15      


Leu Gly Gly Gly Ser Ser Arg Leu Thr Ala Leu Leu Gly Gln Pro Arg 
            20                  25                  30          


Pro Gly Pro Ala Arg Arg Pro Tyr 
        35                  40  


<210>  415
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P49821 mitochondrial targeting peptide

<400>  415

Met Leu Ala Thr Arg Arg Leu Leu Gly Trp Ser Leu Pro Ala Arg Val 
1               5                   10                  15      


Ser Val Arg Phe 
            20  


<210>  416
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P49916 mitochondrial targeting peptide

<400>  416

Met Ser Leu Ala Phe Lys Ile Phe Phe Pro Gln Thr Leu Arg Ala Leu 
1               5                   10                  15      


Ser Arg Lys Glu Leu Cys Leu Phe Arg Lys His His Trp Arg Asp Val 
            20                  25                  30          


Arg Gln Phe Ser Gln Trp Ser Glu Thr Asp 
        35                  40          


<210>  417
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P50213 mitochondrial targeting peptide

<400>  417

Met Ala Gly Pro Ala Trp Ile Ser Lys Val Ser Arg Leu Leu Gly Ala 
1               5                   10                  15      


Phe His Asn Pro Lys Gln Val Thr Arg Gly Phe 
            20                  25          


<210>  418
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P50440 mitochondrial targeting peptide

<400>  418

Met Leu Arg Val Arg Cys Leu Arg Gly Gly Ser Arg Gly Ala Glu Ala 
1               5                   10                  15      


Val His Tyr Ile Gly Ser Arg Leu Gly Arg Thr Leu Thr Gly Trp Val 
            20                  25                  30          


Gln Arg Thr Phe Gln 
        35          


<210>  419
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P51398 mitochondrial targeting peptide

<400>  419

Met Met Leu Lys Gly Ile Thr Arg Leu Ile Ser Arg Ile His Lys Leu 
1               5                   10                  15      


Asp Pro 
        


<210>  420
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P51553 mitochondrial targeting peptide

<400>  420

Met Ala Leu Lys Val Ala Thr Val Ala Gly Ser Ala Ala Lys Ala Val 
1               5                   10                  15      


Leu Gly Pro Ala Leu Leu Cys Arg Pro Trp Glu Val Leu Gly Ala His 
            20                  25                  30          


Glu Val Pro Ser Arg Asn Ile 
        35                  


<210>  421
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P51649 mitochondrial targeting peptide

<400>  421

Met Ala Thr Cys Ile Trp Leu Arg Ser Cys Gly Ala Arg Arg Leu Gly 
1               5                   10                  15      


Ser Thr Phe Pro Gly Cys Arg Leu Arg Pro Arg Ala Gly Gly Leu Val 
            20                  25                  30          


Pro Ala Ser Gly Pro Ala Pro Gly Pro Ala Gln Leu Arg Cys Tyr 
        35                  40                  45          


<210>  422
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P51687 mitochondrial targeting peptide

<400>  422

Met Leu Leu Leu His Arg Ala Val Val Leu Arg Leu Gln Gln Ala Cys 
1               5                   10                  15      


Arg Leu Lys Ser Ile Pro Ser Arg Ile Cys Ile Gln Ala Cys Ser Thr 
            20                  25                  30          


Asn Asp Ser Phe Gln Pro Gln Arg Pro Ser Leu Thr Phe Ser Gly Asp 
        35                  40                  45              


Asn Ser Ser Thr Gln Gly Trp Arg Val Met Gly Thr Leu Leu Gly Leu 
    50                  55                  60                  


Gly Ala Val Leu Ala Tyr Gln Asp His Arg Cys Arg Ala Ala Gln 
65                  70                  75                  


<210>  423
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P52815 mitochondrial targeting peptide

<400>  423

Met Leu Pro Ala Ala Ala Arg Pro Leu Trp Gly Pro Cys Leu Gly Leu 
1               5                   10                  15      


Arg Ala Ala Ala Phe Arg Leu Ala Arg Arg Gln Val Pro Cys Val Cys 
            20                  25                  30          


Ala Val Arg His Met Arg Ser Ser Gly His Gln Arg Cys 
        35                  40                  45  


<210>  424
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P53007 mitochondrial targeting peptide

<400>  424

Met Pro Ala Pro Arg Ala Pro Arg Ala Leu Ala Ala Ala 
1               5                   10              


<210>  425
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P53597 mitochondrial targeting peptide

<400>  425

Met Thr Ala Thr Leu Ala Ala Ala Ala Asp Ile Ala Thr Met Val Ser 
1               5                   10                  15      


Gly Ser Ser Gly Leu Ala Ala Ala Arg Leu Leu Ser Arg Ser Phe Leu 
            20                  25                  30          


Leu Pro Gln Asn Gly Ile Arg His 
        35                  40  


<210>  426
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P54868 mitochondrial targeting peptide

<400>  426

Met Gln Arg Leu Leu Thr Pro Val Lys Arg Ile Leu Gln Leu Thr Arg 
1               5                   10                  15      


Ala Val Gln Glu Thr Ser Leu Thr Pro Ala Arg Leu Leu Pro Val Ala 
            20                  25                  30          


His Gln Arg Phe Ser 
        35          


<210>  427
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P55084 mitochondrial targeting peptide

<400>  427

Met Thr Ile Leu Thr Tyr Pro Phe Lys Asn Leu Pro Thr Ala Ser Lys 
1               5                   10                  15      


Trp Ala Leu Arg Phe Ser Ile Arg Pro Leu Ser Cys Ser Ser Gln Leu 
            20                  25                  30          


Arg 
    


<210>  428
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P55809 mitochondrial targeting peptide

<400>  428

Met Ala Ala Leu Lys Leu Leu Ser Ser Gly Leu Arg Leu Cys Ala Ser 
1               5                   10                  15      


Ala Arg Gly Ser Gly Ala Thr Trp Tyr Lys Gly Cys Val Cys Ser Phe 
            20                  25                  30          


Ser Thr Ser Ala His Arg His 
        35                  


<210>  429
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P56181 mitochondrial targeting peptide

<400>  429

Met Ala Ala Pro Cys Leu Leu Arg Gln Gly Arg Ala Gly Ala Leu Lys 
1               5                   10                  15      


Thr Met Leu Gln Glu Ala Gln Val Phe Arg Gly Leu Ala Ser Thr Val 
            20                  25                  30          


Ser Leu 
        


<210>  430
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P59942 mitochondrial targeting peptide

<400>  430

Met Val Leu Pro Leu Pro Trp Leu Ser Arg Tyr His Phe Leu Arg Leu 
1               5                   10                  15      


Leu Leu Pro Ser Trp Ser Leu Ala 
            20                  


<210>  431
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P78540 mitochondrial targeting peptide

<400>  431

Met Ser Leu Arg Gly Ser Leu Ser Arg Leu Leu Gln Thr Arg Val His 
1               5                   10                  15      


Ser Ile Leu Lys Lys Ser 
            20          


<210>  432
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P78549 mitochondrial targeting peptide

<400>  432

Met Cys Ser Pro Gln Glu Ser Gly Met Thr Ala Leu Ser Ala Arg Met 
1               5                   10                  15      


Leu Thr Arg Ser Arg Ser Leu Gly Pro Gly Ala Gly Pro Arg 
            20                  25                  30  


<210>  433
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P80404 mitochondrial targeting peptide

<400>  433

Met Ala Ser Met Leu Leu Ala Gln Arg Leu Ala Cys Ser Phe Gln His 
1               5                   10                  15      


Ser Tyr Arg Leu Leu Val Pro Gly Ser Arg His Ile 
            20                  25              


<210>  434
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P82914 mitochondrial targeting peptide

<400>  434

Met Leu Arg Val Ala Trp Arg Thr Leu Ser Leu Ile Arg Thr Arg Ala 
1               5                   10                  15      


Val Thr Gln Val Leu Val Pro Gly Leu Pro Gly Gly Gly Ser Ala Lys 
            20                  25                  30          


Phe Pro Phe Asn Gln Trp Gly Leu Gln Pro Arg Ser Leu Leu Leu Gln 
        35                  40                  45              


Ala Ala Arg Gly Tyr Val Val Arg Lys 
    50                  55          


<210>  435
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P83111 mitochondrial targeting peptide

<400>  435

Met Tyr Arg Leu Met Ser Ala Val Thr Ala Arg Ala Ala Ala Pro Gly 
1               5                   10                  15      


Gly Leu Ala Ser Ser Cys Gly Arg Arg Gly Val His Gln Arg Ala Gly 
            20                  25                  30          


Leu Pro Pro Leu Gly His Gly Trp Val Gly Gly Leu Gly Leu Gly Leu 
        35                  40                  45              


Gly Leu Ala Leu Gly Val Lys Leu Ala Gly Gly Leu Arg Gly Ala Ala 
    50                  55                  60                  


Pro Ala Gln Ser Pro Ala Ala Pro Asp Pro Glu Ala Ser Pro Leu Ala 
65                  70                  75                  80  


Glu Pro Pro Gln Glu Gln Ser Leu Ala Pro Trp Ser Pro Gln Thr Pro 
                85                  90                  95      


Ala Pro Pro Cys Ser Arg Cys Phe Ala Arg Ala Ile Glu Ser Ser Arg 
            100                 105                 110         


Asp Leu Leu 
        115 


<210>  436
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q00059 mitochondrial targeting peptide

<400>  436

Met Ala Phe Leu Arg Ser Met Trp Gly Val Leu Ser Ala Leu Gly Arg 
1               5                   10                  15      


Ser Gly Ala Glu Leu Cys Thr Gly Cys Gly Ser Arg Leu Arg Ser Pro 
            20                  25                  30          


Phe Ser Phe Val Tyr Leu Pro Arg Trp Phe 
        35                  40          


<210>  437
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q00325 mitochondrial targeting peptide

<400>  437

Met Phe Ser Ser Val Ala His Leu Ala Arg Ala Asn Pro Phe Asn Thr 
1               5                   10                  15      


Pro His Leu Gln Leu Val His Asp Gly Leu Gly Asp Leu Arg Ser Ser 
            20                  25                  30          


Ser Pro Gly Pro Thr Gly Gln Pro Arg Arg Pro Arg Asn Leu Ala Ala 
        35                  40                  45              


Ala 
    


<210>  438
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q02127 mitochondrial targeting peptide

<400>  438

Met Ala Trp Arg His Leu Lys Lys Arg Ala 
1               5                   10  


<210>  439
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q02218 mitochondrial targeting peptide

<400>  439

Met Phe His Leu Arg Thr Cys Ala Ala Lys Leu Arg Pro Leu Thr Ala 
1               5                   10                  15      


Ser Gln Thr Val Lys Thr Phe Ser Gln Asn Arg Pro Ala Ala Ala Arg 
            20                  25                  30          


Thr Phe Gln Gln Ile Arg Cys Tyr 
        35                  40  


<210>  440
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q02221 mitochondrial targeting peptide

<400>  440

Met Ala Leu Pro Leu Arg Pro Leu Thr Arg Gly Leu 
1               5                   10          


<210>  441
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q02252 mitochondrial targeting peptide

<400>  441

Met Ala Ala Leu Leu Ala Ala Ala Ala Val Arg Ala Arg Ile Leu Gln 
1               5                   10                  15      


Val Ser Ser Lys Val Lys Ser Ser Pro Thr Trp Tyr Ser Ala Ser Ser 
            20                  25                  30          


Phe 
    


<210>  442
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q02318 mitochondrial targeting peptide

<400>  442

Met Ala Ala Leu Gly Cys Ala Arg Leu Arg Trp Ala Leu Arg Gly Ala 
1               5                   10                  15      


Gly Arg Gly Leu Cys Pro His Gly Ala Arg Ala Lys Ala Ala Ile Pro 
            20                  25                  30          


Ala 
    


<210>  443
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q02338 mitochondrial targeting peptide

<400>  443

Met Leu Ala Thr Arg Leu Ser Arg Pro Leu Ser Arg Leu Pro Gly Lys 
1               5                   10                  15      


Thr Leu Ser Ala Cys Asp Arg Glu Asn Gly Ala Arg Arg Pro Leu Leu 
            20                  25                  30          


Leu Gly Ser Thr Ser Phe Ile Pro Ile Gly Arg Arg Thr Tyr 
        35                  40                  45      


<210>  444
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q04837 mitochondrial targeting peptide

<400>  444

Met Phe Arg Arg Pro Val Leu Gln Val Leu Arg Gln Phe Val Arg His 
1               5                   10                  15      


<210>  445
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q05932 mitochondrial targeting peptide

<400>  445

Met Ser Arg Ala Arg Ser His Leu Arg Ala Ala Leu Phe Leu Ala Ala 
1               5                   10                  15      


Ala Ser Ala Arg Gly Ile Thr Thr Gln Val Ala Ala Arg Arg Gly Leu 
            20                  25                  30          


Ser Ala Trp Pro Val Pro Gln Glu Pro Ser 
        35                  40          


<210>  446
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q06055 mitochondrial targeting peptide

<400>  446

Met Phe Ala Cys Ser Lys Phe Val Ser Thr Pro Ser Leu Val Lys Ser 
1               5                   10                  15      


Thr Ser Gln Leu Leu Ser Arg Pro Leu Ser Ala Val Val Leu Lys Arg 
            20                  25                  30          


Pro Glu Ile Leu Thr Asp Glu Ser Leu Ser Ser Leu Ala Val Ser Cys 
        35                  40                  45              


Pro Leu Thr Ser Leu Val Ser Ser Arg Ser Phe Gln Thr Ser Ala Ile 
    50                  55                  60                  


Ser Arg 
65      


<210>  447
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q07021 mitochondrial targeting peptide

<400>  447

Met Leu Pro Leu Leu Arg Cys Val Pro Arg Val Leu Gly Ser Ser Val 
1               5                   10                  15      


Ala Gly Leu Arg Ala Ala Ala Pro Ala Ser Pro Phe Arg Gln Leu Leu 
            20                  25                  30          


Gln Pro Ala Pro Arg Leu Cys Thr Arg Pro Phe Gly Leu Leu Ser Val 
        35                  40                  45              


Arg Ala Gly Ser Glu Arg Arg Pro Gly Leu Leu Arg Pro Arg Gly Pro 
    50                  55                  60                  


Cys Ala Cys Gly Cys Gly Cys Gly Ser 
65                  70              


<210>  448
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q07973 mitochondrial targeting peptide

<400>  448

Met Ser Ser Pro Ile Ser Lys Ser Arg Ser Leu Ala Ala Phe Leu Gln 
1               5                   10                  15      


Gln Leu Arg Ser Pro Arg Gln Pro Pro Arg Leu Val Thr Ser Thr Ala 
            20                  25                  30          


Tyr Thr Ser 
        35  


<210>  449
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q08AH1 mitochondrial targeting peptide

<400>  449

Met Gln Trp Leu Met Arg Phe Arg Thr Leu Trp Gly Ile His Lys Ser 
1               5                   10                  15      


Phe His Asn Ile His Pro Ala Pro Ser Gln Leu Arg Cys Arg Ser 
            20                  25                  30      


<210>  450
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q08AH3 mitochondrial targeting peptide

<400>  450

Met His Trp Leu Arg Lys Val Gln Gly Leu Cys Thr Leu Trp Gly Thr 
1               5                   10                  15      


Gln Met Ser Ser Arg Thr Leu Tyr Ile Asn Ser Arg Gln Leu Val Ser 
            20                  25                  30          


Leu Gln Trp Gly His Gln Glu Val Pro Ala Lys Phe Asn Phe 
        35                  40                  45      


<210>  451
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q10713 mitochondrial targeting peptide

<400>  451

Met Ala Ala Val Val Leu Ala Ala Thr Arg Leu Leu Arg Gly Ser Gly 
1               5                   10                  15      


Ser Trp Gly Cys Ser Arg Leu Arg Phe Gly Pro Pro Ala Tyr Arg Arg 
            20                  25                  30          


Phe 
    


<210>  452
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q12849 mitochondrial targeting peptide

<400>  452

Met Ala Gly Thr Arg Trp Val Leu Gly Ala Leu Leu Arg Gly Cys Gly 
1               5                   10                  15      


Cys Asn Cys Ser Ser Cys Arg Arg Thr Gly Ala Ala Cys Leu Pro Phe 
            20                  25                  30          


Tyr Ser Ala Ala Gly Ser Ile Pro Ser Gly Val Ser Gly Arg Arg Arg 
        35                  40                  45              


Leu Leu Leu Leu Leu Gly Ala Ala Ala Ala Ala Ala Ser Gln Thr Arg 
    50                  55                  60                  


Gly Leu Gln Thr Gly Pro Val Pro Pro Gly Arg Leu Ala Gly Pro Pro 
65                  70                  75                  80  


Ala Val Ala Thr Ser Ala Ala Ala Ala Ala Ala Ala Ser Tyr Ser Ala 
                85                  90                  95      


Leu Arg Ala Ser Leu Leu Pro Gln Ser Leu Ala Ala Ala Ala Ala Val 
            100                 105                 110         


Pro Thr Arg Ser Tyr 
        115         


<210>  453
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q12931 mitochondrial targeting peptide

<400>  453

Met Ala Arg Glu Leu Arg Ala Leu Leu Leu Trp Gly Arg Arg Leu Arg 
1               5                   10                  15      


Pro Leu Leu Arg Ala Pro Ala Leu Ala Ala Val Pro Gly Gly Lys Pro 
            20                  25                  30          


Ile Leu Cys Pro Arg Arg Thr Thr Ala Gln Leu Gly Pro Arg Arg Asn 
        35                  40                  45              


Pro Ala Trp Ser Leu Gln Ala Gly Arg Leu Phe 
    50                  55                  


<210>  454
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q13011 mitochondrial targeting peptide

<400>  454

Met Ala Ala Gly Ile Val Ala Ser Arg Arg Leu Arg Asp Leu Leu Thr 
1               5                   10                  15      


Arg Arg Leu Thr Gly Ser Asn Tyr Pro Gly Leu Ser Ile Ser Leu Arg 
            20                  25                  30          


Leu 
    


<210>  455
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q13084 mitochondrial targeting peptide

<400>  455

Met Pro Leu His Lys Tyr Pro Val Trp Leu Trp Lys Arg Leu Gln Leu 
1               5                   10                  15      


Arg Glu Gly Ile Cys Ser Arg Leu Pro Gly His Tyr Leu Arg Ser Leu 
            20                  25                  30          


Glu Glu Glu Arg Thr Pro Thr Pro Val His Tyr Arg Pro His Gly Ala 
        35                  40                  45              


Lys Phe Lys Ile Asn Pro Lys 
    50                  55  


<210>  456
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q13268 mitochondrial targeting peptide

<400>  456

Met Leu Ser Ala Val Ala Arg Gly Tyr Gln Gly Trp Phe His Pro Cys 
1               5                   10                  15      


Ala Arg Leu Ser Val Arg Met 
            20              


<210>  457
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q13423 mitochondrial targeting peptide

<400>  457

Met Ala Asn Leu Leu Lys Thr Val Val Thr Gly Cys Ser Cys Pro Leu 
1               5                   10                  15      


Leu Ser Asn Leu Gly Ser Cys Lys Gly Leu Arg Val Lys Lys Asp Phe 
            20                  25                  30          


Leu Arg Thr Phe Tyr Thr His Gln Glu Leu Trp 
        35                  40              


<210>  458
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q13825 mitochondrial targeting peptide

<400>  458

Met Ala Ala Ala Val Ala Ala Ala Pro Gly Ala Leu Gly Ser Leu His 
1               5                   10                  15      


Ala Gly Gly Ala Arg Leu Val Ala Ala Cys Ser Ala Trp Leu Cys Pro 
            20                  25                  30          


Gly Leu Arg Leu Pro Gly Ser Leu Ala Gly Arg Arg Ala Gly Pro Ala 
        35                  40                  45              


Ile Trp Ala Gln Gly Trp Val Pro Ala Ala Gly Gly Pro Ala Pro Lys 
    50                  55                  60                  


Arg Gly Tyr 
65          


<210>  459
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q14154 mitochondrial targeting peptide

<400>  459

Met Trp Arg Leu Pro Gly Leu Leu Gly Arg Ala Leu Pro Arg Thr Leu 
1               5                   10                  15      


Gly Pro Ser Leu Trp Arg Val Thr Pro Lys Ser Thr Ser Pro Asp Gly 
            20                  25                  30          


Pro Gln Thr Thr Ser Ser Thr Leu Leu Val Pro Val Pro Asn Leu Asp 
        35                  40                  45              


Arg Ser Gly Pro His Gly Pro Gly Thr Ser Gly Gly Pro Arg Ser His 
    50                  55                  60                  


Gly Trp Lys Asp Ala Phe Gln Trp Met Ser Ser Arg Val Ser Pro Asn 
65                  70                  75                  80  


Thr Leu Trp Asp Ala Ile Ser Trp Gly Thr Leu Ala Val Leu Ala Leu 
                85                  90                  95      


Gln Leu Ala Arg Gln 
            100     


<210>  460
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q14197 mitochondrial targeting peptide

<400>  460

Met Ala Ala Thr Arg Cys Leu Arg Trp Gly Leu Ser Arg Ala Gly Val 
1               5                   10                  15      


Trp Leu Leu Pro Pro Pro Ala Arg Cys Pro Arg Arg Ala 
            20                  25                  


<210>  461
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q14249 mitochondrial targeting peptide

<400>  461

Met Arg Ala Leu Arg Ala Gly Leu Thr Leu Ala Ser Gly Ala Gly Leu 
1               5                   10                  15      


Gly Ala Val Val Glu Gly Trp Arg Arg Arg Arg Glu Asp Ala Arg Ala 
            20                  25                  30          


Ala Pro Gly Leu Leu Gly Arg Leu Pro Val Leu Pro Val Ala Ala Ala 
        35                  40                  45              


<210>  462
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q15118 mitochondrial targeting peptide

<400>  462

Met Arg Leu Ala Arg Leu Leu Arg Gly Ala Ala Leu Ala Gly Pro Gly 
1               5                   10                  15      


Pro Gly Leu Arg Ala Ala Gly Phe Ser Arg Ser Phe 
            20                  25              


<210>  463
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q15390 mitochondrial targeting peptide

<400>  463

Met Leu Gly Trp Ile Lys Arg Leu Ile Arg Met Val Phe Gln Gln Val 
1               5                   10                  15      


Gly Val Ser Met Gln Ser Val Leu Trp Ser Arg Lys Pro Tyr Gly Ser 
            20                  25                  30          


Ser Arg Ser Ile Val Arg Lys Ile Gly Thr Asn Leu Ser Leu Ile Gln 
        35                  40                  45              


<210>  464
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q16134 mitochondrial targeting peptide

<400>  464

Met Leu Val Pro Leu Ala Lys Leu Ser Cys Leu Ala Tyr Gln Cys Phe 
1               5                   10                  15      


His Ala Leu Lys Ile Lys Lys Asn Tyr Leu Pro Leu Cys Ala Thr Arg 
            20                  25                  30          


Trp 
    


<210>  465
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q16595 mitochondrial targeting peptide

<400>  465

Met Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro 
1               5                   10                  15      


Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu 
            20                  25                  30          


Leu Ala Pro Leu Cys Gly Arg Arg Gly 
        35                  40      


<210>  466
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q16698 mitochondrial targeting peptide

<400>  466

Met Lys Leu Pro Ala Arg Val Phe Phe Thr Leu Gly Ser Arg Leu Pro 
1               5                   10                  15      


Cys Gly Leu Ala Pro Arg Arg Phe Phe Ser Tyr Gly Thr Lys Ile Leu 
            20                  25                  30          


Tyr Gln 
        


<210>  467
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q16740 mitochondrial targeting peptide

<400>  467

Met Trp Pro Gly Ile Leu Val Gly Gly Ala Arg Val Ala Ser Cys Arg 
1               5                   10                  15      


Tyr Pro Ala Leu Gly Pro Arg Leu Ala Ala His Phe Pro Ala Gln Arg 
            20                  25                  30          


Pro Pro Gln Arg Thr Leu Gln Asn Gly Leu Ala Leu Gln Arg Cys Leu 
        35                  40                  45              


His Ala Thr Ala Thr Arg Ala Leu 
    50                  55      


<210>  468
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q16775 mitochondrial targeting peptide

<400>  468

Met Val Val Gly Arg Gly Leu Leu Gly Arg Arg Ser Leu 
1               5                   10              


<210>  469
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q16795 mitochondrial targeting peptide

<400>  469

Met Ala Ala Ala Ala Gln Ser Arg Val Val Arg Val Leu Ser Met Ser 
1               5                   10                  15      


Arg Ser Ala Ile Thr Ala Ile Ala Thr Ser Val Cys His Gly Pro Pro 
            20                  25                  30          


Cys Arg Gln 
        35  


<210>  470
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q16822 mitochondrial targeting peptide

<400>  470

Met Ala Ala Leu Tyr Arg Pro Gly Leu Arg Leu Asn Trp His Gly Leu 
1               5                   10                  15      


Ser Pro Leu Gly Trp Pro Ser Cys Arg Ser Ile Gln Thr Leu Arg Val 
            20                  25                  30          


<210>  471
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q16836 mitochondrial targeting peptide

<400>  471

Met Ala Phe Val Thr Arg Gln Phe Met Arg Ser Val 
1               5                   10          


<210>  472
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q16854 mitochondrial targeting peptide

<400>  472

Met Ala Ala Gly Arg Leu Phe Leu Ser Arg Leu Arg Ala Pro Phe Ser 
1               5                   10                  15      


Ser Met Ala Lys Ser Pro Leu Glu Gly Val Ser Ser Ser Arg Gly Leu 
            20                  25                  30          


His Ala Gly Arg Gly Pro Arg 
        35                  


<210>  473
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q16891 mitochondrial targeting peptide

<400>  473

Met Leu Arg Ala Cys Gln Leu Ser Gly Val Thr Ala Ala Ala Gln Ser 
1               5                   10                  15      


Cys Leu Cys Gly Lys Phe Val Leu Arg Pro Leu Arg Pro Cys Arg Arg 
            20                  25                  30          


Tyr 
    


<210>  474
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q2VYF4 mitochondrial targeting peptide

<400>  474

Met Ala Phe Tyr Ser Tyr Asn Ser Val Leu Ala Ile Ala Arg Thr Arg 
1               5                   10                  15      


Phe Pro Ser His Phe Val His Pro Thr 
            20                  25  


<210>  475
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q32NB8 mitochondrial targeting peptide

<400>  475

Met Ala Val Ala Ala Ala Ala Ala Ala Gly Pro Val Phe Trp Arg Arg 
1               5                   10                  15      


Leu Leu Gly Leu Leu Pro Gly Arg Pro Gly Leu Ala 
            20                  25              


<210>  476
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q330K2 mitochondrial targeting peptide

<400>  476

Met Ala Ala Ser Ala His Gly Ser Val Trp Gly Pro Leu Arg Leu Gly 
1               5                   10                  15      


Ile Pro Gly Leu Cys Cys Arg Arg Pro Pro Leu Gly Leu Tyr Ala Arg 
            20                  25                  30          


Met Arg Arg Leu Pro Gly Pro Glu Val Ser Gly Arg 
        35                  40                  


<210>  477
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q3SY69 mitochondrial targeting peptide

<400>  477

Met Leu Arg Arg Gly Ser Gln Ala Leu Arg Arg Phe Ser Thr Gly Arg 
1               5                   10                  15      


Val Tyr Phe 
            


<210>  478
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q3ZCQ8 mitochondrial targeting peptide

<400>  478

Met Ala Ala Ser Ala Ala Val Phe Ser Arg Leu Arg Ser Gly Leu Arg 
1               5                   10                  15      


Leu Gly Ser Arg Gly Leu Cys Thr Arg Leu Ala Thr Pro Pro Arg Arg 
            20                  25                  30          


Ala Pro Asp Gln Ala Ala Glu Ile Gly Ser Arg Gly 
        35                  40                  


<210>  479
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q49AM1 mitochondrial targeting peptide

<400>  479

Met Leu Trp Lys Leu Leu Leu Arg Ser Gln Ser Cys Arg Leu Cys Ser 
1               5                   10                  15      


Phe Arg Lys Met Arg Ser Pro Pro Lys Tyr Arg Pro Phe Leu Ala Cys 
            20                  25                  30          


Phe Thr Tyr 
        35  


<210>  480
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q4G0N4 mitochondrial targeting peptide

<400>  480

Met Thr Cys Tyr Arg Gly Phe Leu Leu Gly Ser Cys Cys Arg Val Ala 
1               5                   10                  15      


Gly Gly Arg Ala Ala Ala Leu Arg Gly Pro Gly Ala Gly Gly Pro Ala 
            20                  25                  30          


Ala Arg Pro Arg Leu Gly Gly Asp Gly Gly Gly Arg Arg His Leu Gly 
        35                  40                  45              


Gln Gly Gln Pro Arg Glu Leu Ala Gly Cys Gly Ser Arg Ala 
    50                  55                  60          


<210>  481
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q4G176 mitochondrial targeting peptide

<400>  481

Met Leu Pro His Val Val Leu Thr Phe Arg Arg Leu Gly Cys Ala Leu 
1               5                   10                  15      


Ala Ser Cys Arg Leu Ala Pro Ala Arg His Arg Gly Ser Gly Leu Leu 
            20                  25                  30          


His Thr Ala Pro Val Ala Arg Ser Asp Arg Ser Ala Pro Val Phe Thr 
        35                  40                  45              


Arg Ala Leu Ala Phe Gly Asp Arg Ile Ala Leu Val Asp Gln His Gly 
    50                  55                  60                  


Arg His Thr Tyr Arg Glu Leu Tyr Ser Arg Ser Leu Arg Leu Ser Gln 
65                  70                  75                  80  


Glu Ile Cys 
            


<210>  482
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q4U2R6 mitochondrial targeting peptide

<400>  482

Met Ala Gly Asn Leu Leu Ser Gly Ala Gly Arg Arg Leu Trp Asp Trp 
1               5                   10                  15      


Val Pro Leu Ala Cys Arg Ser Phe Ser Leu Gly Val Pro Arg Leu 
            20                  25                  30      


<210>  483
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q53FZ2 mitochondrial targeting peptide

<400>  483

Met Leu Ala Arg Val Thr Arg Lys Met Leu Arg His Ala Lys Cys Phe 
1               5                   10                  15      


Gln Arg Leu Ala Ile Phe Gly Ser Val Arg Ala 
            20                  25          


<210>  484
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q53H12 mitochondrial targeting peptide

<400>  484

Met Thr Val Phe Phe Lys Thr Leu Arg Asn His Trp Lys Lys Thr Thr 
1               5                   10                  15      


Ala Gly Leu Cys Leu Leu Thr Trp Gly Gly His Trp Leu Tyr Gly 
            20                  25                  30      


<210>  485
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q5EBM0 mitochondrial targeting peptide

<400>  485

Met Ala Phe Ala Arg Arg Leu Leu Arg Gly Pro Leu Ser Gly Pro Leu 
1               5                   10                  15      


Leu Gly Arg Arg Gly Val Cys Ala Gly Ala Met Ala Pro Pro Arg Arg 
            20                  25                  30          


Phe Val Leu Glu Leu Pro Asp Cys Thr Leu Ala His Phe Ala Leu Gly 
        35                  40                  45              


Ala Asp Ala Pro Gly Asp Ala Asp Ala Pro Asp Pro Arg Leu Ala Ala 
    50                  55                  60                  


Leu Leu Gly Pro Pro Glu Arg Ser Tyr Ser Leu Cys Val Pro Val Thr 
65                  70                  75                  80  


Pro Asp Ala Gly Cys Gly Ala Arg Val Arg Ala Ala Arg Leu His Gln 
                85                  90                  95      


Arg Leu 
        


<210>  486
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q5HYK3 mitochondrial targeting peptide

<400>  486

Met Ala Ala Pro Gly Ser Cys Ala Leu Trp Ser Tyr Cys Gly Arg Gly 
1               5                   10                  15      


Trp Ser Arg Ala Met Arg Gly Cys Gln Leu Leu Gly Leu Arg Ser Ser 
            20                  25                  30          


Trp Pro Gly Asp Leu Leu Ser Ala Arg Leu 
        35                  40          


<210>  487
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q5JPH6 mitochondrial targeting peptide

<400>  487

Met Ala Ala Leu Leu Arg Arg Leu Leu Gln Arg Glu Arg Pro Ser Ala 
1               5                   10                  15      


Ala Ser Gly Arg Pro Val Gly Arg Arg Glu Ala Asn Leu Gly Thr Asp 
            20                  25                  30          


Ala Gly Val Ala Val Arg Val Arg Phe 
        35                  40      


<210>  488
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q5JRX3 mitochondrial targeting peptide

<400>  488

Met Trp Arg Cys Gly Gly Arg Gln Gly Leu Cys Val Leu Arg Arg 
1               5                   10                  15  


<210>  489
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q5JTZ9 mitochondrial targeting peptide

<400>  489

Met Ala Ala Ser Val Ala Ala Ala Ala Arg Arg Leu Arg Arg Ala Ile 
1               5                   10                  15      


Arg Arg Ser Pro Ala Trp Arg 
            20              


<210>  490
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q5ST30 mitochondrial targeting peptide

<400>  490

Met Pro His Leu Pro Leu Ala Ser Phe Arg Pro Pro Phe Trp Gly Leu 
1               5                   10                  15      


Arg His Ser Arg Gly Leu Pro Arg Phe His 
            20                  25      


<210>  491
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q5SXM8 mitochondrial targeting peptide

<400>  491

Met Leu Arg Thr Ala Leu Arg Gly Ala Pro Arg Leu Leu Ser Arg Val 
1               5                   10                  15      


Gln Pro Arg Ala Pro Cys Leu Arg Arg Leu Trp Gly Arg Gly Ala Arg 
            20                  25                  30          


Pro Glu Val Ala Gly Arg Arg Arg Ala Trp Ala Trp Gly Trp Arg Arg 
        35                  40                  45              


Ser 
    


<210>  492
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q5T160 mitochondrial targeting peptide

<400>  492

Met Ala Cys Gly Phe Arg Arg Ala Ile Ala Cys Gln Leu Ser Arg Val 
1               5                   10                  15      


<210>  493
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q5T1C6 mitochondrial targeting peptide

<400>  493

Met Leu Arg Ser Cys Ala Ala Arg Leu Arg Thr Leu Gly Ala Leu Cys 
1               5                   10                  15      


Leu Pro Pro Val Gly Arg Arg Leu Pro Gly Ser Glu Pro Arg Pro Glu 
            20                  25                  30          


Leu Arg Ser Phe 
        35      


<210>  494
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q5T1J5 mitochondrial targeting peptide

<400>  494

Met Pro Arg Gly Ser Arg Ser Arg Thr 
1               5                   


<210>  495
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q5T440 mitochondrial targeting peptide

<400>  495

Met Ala Thr Ala Ala Leu Leu Arg Gly Ala Thr Pro Gly Arg Gly Gly 
1               5                   10                  15      


Pro Val Trp Arg Trp Arg Leu Arg Ala Ala Pro Arg Cys Arg Leu Ala 
            20                  25                  30          


His Ser Ser Cys Ser Pro Gly 
        35                  


<210>  496
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q5T653 mitochondrial targeting peptide

<400>  496

Met Ala Leu Cys Ala Leu Thr Arg Ala Leu Arg Ser Leu Asn Leu Ala 
1               5                   10                  15      


Pro Pro Thr Val Ala Ala Pro Ala Pro Ser Leu Phe Pro Ala Ala Gln 
            20                  25                  30          


Met Met Asn Asn Gly Leu Leu Gln Gln Pro Ser Ala Leu Met Leu Leu 
        35                  40                  45              


Pro Cys Arg Pro Val Leu Thr Ser Val Ala Leu Asn 
    50                  55                  60  


<210>  497
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q5TC12 mitochondrial targeting peptide

<400>  497

Met Ala Ala Val Val Val Ala Ala Ala Gly Gly Ala Gly Pro Ala Val 
1               5                   10                  15      


Leu Gln Val Ala Gly Leu Tyr Arg Gly Leu Cys Ala Val Arg Ser Arg 
            20                  25                  30          


Ala Leu Gly Leu Gly Leu Val Ser Pro Ala Gln Leu Arg Val Phe Pro 
        35                  40                  45              


Val Arg Pro Gly Ser Gly Arg Pro Glu 
    50                  55          


<210>  498
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q5TEU4 mitochondrial targeting peptide

<400>  498

Met Leu Arg Pro Ala Gly Leu Trp Arg Leu Cys Arg Arg Pro Trp Ala 
1               5                   10                  15      


Ala Arg Val Pro Ala Glu Asn Leu Gly Arg Arg Glu Val Thr Ser Gly 
            20                  25                  30          


Val Ser Pro Arg 
        35      


<210>  499
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q5U4N7 mitochondrial targeting peptide

<400>  499

Met Ile Gln Ser Ser Gln Pro Met Ser Leu Lys Leu Thr Cys Ser Ala 
1               5                   10                  15      


Phe Arg Leu Gln Arg Ala Leu Arg Phe Leu Leu Gly Arg Leu Pro Trp 
            20                  25                  30          


Arg Val Ala Ser Gly Ala Arg Arg Phe Arg Arg Trp Leu Asn Arg Tyr 
        35                  40                  45              


<210>  500
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q5VUM1 mitochondrial targeting peptide

<400>  500

Met Thr Pro Ser Arg Leu Pro Trp Leu Leu Ser Trp Val Ser Ala Thr 
1               5                   10                  15      


Ala Trp Arg Ala 
            20  


<210>  501
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q68CK6 mitochondrial targeting peptide

<400>  501

Met His Trp Leu Arg Lys Val Gln Gly Leu Cys Thr Leu Trp Gly Thr 
1               5                   10                  15      


Gln Met Ser Ser Arg Thr Leu Tyr Ile Asn Ser Arg Gln Leu Val Ser 
            20                  25                  30          


Leu Gln Trp Gly His Gln Glu Val Pro Ala Lys Phe Asn Phe 
        35                  40                  45      


<210>  502
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q6DKK2 mitochondrial targeting peptide

<400>  502

Met Phe Arg Leu Leu Ser Trp Ser Leu Gly Arg Gly Phe Leu Arg Ala 
1               5                   10                  15      


Ala Gly Arg Arg Cys Arg Gly Cys Ser Ala Arg Leu Leu Pro Gly Leu 
            20                  25                  30          


Ala Gly Gly Pro Gly Pro Glu Val Gln Val Pro Pro Ser Arg Val Ala 
        35                  40                  45              


Pro His Gly Arg Gly Pro Gly Leu Leu Pro Leu Leu Ala Ala Leu Ala 
    50                  55                  60                  


Trp Phe Ser Arg Pro Ala 
65                  70  


<210>  503
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q6IN84 mitochondrial targeting peptide

<400>  503

Met Ala Leu Leu Ser Thr Val Arg Gly Ala Thr Trp Gly Arg Leu Val 
1               5                   10                  15      


Thr Arg His Phe 
            20  


<210>  504
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q6J4K2 mitochondrial targeting peptide

<400>  504

Met Ala Gly Arg Arg Leu Asn Leu Arg Trp Ala Leu Ser Val Leu Cys 
1               5                   10                  15      


Val Leu Leu Met Ala Glu Thr Val Ser Gly 
            20                  25      


<210>  505
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q6L8Q7 mitochondrial targeting peptide

<400>  505

Met Trp Arg Leu Pro Gly Ala Arg Ala Ala Leu Arg Val Ile Arg Thr 
1               5                   10                  15      


<210>  506
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q6NUN0 mitochondrial targeting peptide

<400>  506

Met Arg Pro Trp Leu Arg His Leu Val Leu Gln Ala Leu Arg Asn Ser 
1               5                   10                  15      


Arg Ala Phe Cys Gly Ser His Gly Lys Pro 
            20                  25      


<210>  507
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q6NVY1 mitochondrial targeting peptide

<400>  507

Met Gly Gln Arg Glu Met Trp Arg Leu Met Ser Arg Phe Asn Ala Phe 
1               5                   10                  15      


Lys Arg Thr Asn Thr Ile Leu His His Leu Arg Met Ser Lys His Thr 
            20                  25                  30          


<210>  508
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q6P161 mitochondrial targeting peptide

<400>  508

Met Ala Thr Lys Arg Leu Phe Gly Ala Thr Arg Thr Trp Ala 
1               5                   10                  


<210>  509
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q6P1L8 mitochondrial targeting peptide

<400>  509

Met Ala Phe Phe Thr Gly Leu Trp Gly Pro Phe Thr Cys Val Ser Arg 
1               5                   10                  15      


Val Leu Ser His His Cys Phe Ser Thr Thr Gly Ser Leu Ser 
            20                  25                  30  


<210>  510
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q6P461 mitochondrial targeting peptide

<400>  510

Met Leu Gly Arg Phe Gln Pro Phe Ser Leu Val Arg Ser Phe Arg Leu 
1               5                   10                  15      


Gly Phe Glu Ala Cys 
            20      


<210>  511
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q6P4F2 mitochondrial targeting peptide

<400>  511

Met Ala Ala Ser Met Ala Arg Gly Gly Val Ser Ala Arg Val Leu Leu 
1               5                   10                  15      


Gln Ala Ala Arg Gly Thr Trp Trp Asn Arg Pro Gly Gly Thr Ser Gly 
            20                  25                  30          


Ser Gly Glu Gly Val Ala Leu Gly Thr Thr Arg Lys Phe Gln Ala Thr 
        35                  40                  45              


Gly Ser Arg Pro 
    50          


<210>  512
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q6P587 mitochondrial targeting peptide

<400>  512

Met Gly Ile Met Ala Ala Ser Arg Pro Leu Ser Arg Phe Trp Glu Trp 
1               5                   10                  15      


Gly Lys Asn Ile Val Cys Val Gly Arg Asn Tyr 
            20                  25          


<210>  513
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q6PI48 mitochondrial targeting peptide

<400>  513

Met Tyr Phe Pro Ser Trp Leu Ser Gln Leu Tyr Arg Gly Leu Ser Arg 
1               5                   10                  15      


Pro Ile Arg Arg Thr Thr Gln Pro Ile Trp Gly Ser Leu Tyr Arg Ser 
            20                  25                  30          


Leu Leu Gln Ser Ser Gln Arg Arg Ile Pro Glu Phe Ser Ser Phe 
        35                  40                  45          


<210>  514
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q6SZW1 mitochondrial targeting peptide

<400>  514

Met Val Leu Thr Leu Leu Leu Ser Ala Tyr Lys Leu Cys Arg Phe Phe 
1               5                   10                  15      


Ala Met Ser Gly Pro Arg Pro Gly Ala Glu Arg 
            20                  25          


<210>  515
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q6UB28 mitochondrial targeting peptide

<400>  515

Met Ala Ala Pro Ser Gly Val His Leu Leu Val Arg Arg Gly Ser His 
1               5                   10                  15      


Arg Ile Phe 
            


<210>  516
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q6UB35 mitochondrial targeting peptide

<400>  516

Met Gly Thr Arg Leu Pro Leu Val Leu Arg Gln Leu Arg Arg Pro Pro 
1               5                   10                  15      


Gln Pro Pro Gly Pro Pro Arg Arg Leu Arg Val Pro Cys Arg Ala 
            20                  25                  30      


<210>  517
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q6UWS5 mitochondrial targeting peptide

<400>  517

Met Ser Arg Ser Ser Lys Val Val Leu Gly Leu Ser Val Leu Leu Thr 
1               5                   10                  15      


Ala Ala Thr Val Ala Gly 
            20          


<210>  518
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q6UXV4 mitochondrial targeting peptide

<400>  518

Met Ala Ala Ile Arg Met Gly Lys Leu Thr Thr Met Pro Ala Gly Leu 
1               5                   10                  15      


Ile Tyr Ala Ser Val Ser Val His Ala Ala Lys 
            20                  25          


<210>  519
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q6ZSR3 mitochondrial targeting peptide

<400>  519

Met Gly Trp Arg Phe Pro Ser Pro Ser Pro Arg Gln Ala Ser Pro Val 
1               5                   10                  15      


Ala Pro Leu Leu Ala Ala Pro Thr Ala Val Arg Ser Cys 
            20                  25                  


<210>  520
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q7L0Y3 mitochondrial targeting peptide

<400>  520

Met Ala Ala Phe Leu Lys Met Ser Val Ser Val Asn Phe Phe Arg Pro 
1               5                   10                  15      


Phe Thr Arg Phe Leu Val Pro Phe Thr Leu His Arg Lys Arg Asn Asn 
            20                  25                  30          


Leu Thr Ile Leu Gln Arg Tyr 
        35                  


<210>  521
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q7L3T8 mitochondrial targeting peptide

<400>  521

Met Glu Gly Leu Leu Thr Arg Cys Arg Ala Leu Pro Ala Leu Ala Thr 
1               5                   10                  15      


Cys Ser Arg Gln Leu Ser Gly Tyr Val Pro Cys Arg Phe 
            20                  25                  


<210>  522
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q7L592 mitochondrial targeting peptide

<400>  522

Met Ser Val Leu Leu Arg Ser Gly Leu Gly Pro Leu Cys Ala Val Ala 
1               5                   10                  15      


Arg Ala Ala Ile Pro Phe Ile Trp Arg Gly Lys Tyr Phe Ser Ser Gly 
            20                  25                  30          


Asn Glu Pro Ala Glu Asn Pro Val Thr Pro Met Leu Arg His 
        35                  40                  45      


<210>  523
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q7L8L6 mitochondrial targeting peptide

<400>  523

Met Ala Ala Thr Leu Lys Ser Leu Lys Leu Val Arg Tyr Arg Ala Phe 
1               5                   10                  15      


Cys Ser Pro Ser Ala Phe Gly Ala Val Arg Ser 
            20                  25          


<210>  524
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q7Z2W9 mitochondrial targeting peptide

<400>  524

Met Ala Ala Ser Ser Leu Thr Val Thr Leu Gly Arg Leu Ala Ser Ala 
1               5                   10                  15      


Cys Ser His Ser Ile Leu Arg Pro Ser Gly Pro Gly Ala Ala Ser Leu 
            20                  25                  30          


Trp Ser Ala Ser Arg Arg Phe 
        35                  


<210>  525
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q7Z3D6 mitochondrial targeting peptide

<400>  525

Met Pro Phe Thr Leu His Leu Arg Ser Arg Leu Pro Ser Ala Ile Arg 
1               5                   10                  15      


Ser Leu Ile Leu Gln Lys Lys Pro Asn Ile Arg Asn 
            20                  25              


<210>  526
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q7Z4L0 mitochondrial targeting peptide

<400>  526

Met Pro Leu Leu Arg Gly Arg Cys Pro Ala Arg Arg His Tyr Arg Arg 
1               5                   10                  15      


Leu Ala Leu Leu Gly Leu Gln Pro Ala Pro Arg Phe Ala 
            20                  25                  


<210>  527
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q7Z5L4 mitochondrial targeting peptide

<400>  527

Met Ile Ile Thr Thr Trp Ile Val Tyr Ile Leu Ala Arg Lys Gly Val 
1               5                   10                  15      


Gly Leu Pro Phe Leu Pro Ile Thr 
            20                  


<210>  528
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q7Z6M4 mitochondrial targeting peptide

<400>  528

Met Ala Ala Phe Gly Arg Gln Val Leu Asp Trp His Arg Leu Ile Pro 
1               5                   10                  15      


Leu Thr Trp Ala Cys Met Ala Arg Gln Thr Pro His Leu Gly Glu Gln 
            20                  25                  30          


Arg Arg Thr Thr Ala Ser Leu Leu Arg Lys 
        35                  40          


<210>  529
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q7Z7F7 mitochondrial targeting peptide

<400>  529

Met Ala Ala Val Gly Ser Leu Leu Gly Arg Leu Arg Gln Ser Thr Val 
1               5                   10                  15      


Lys Ala Thr Gly Pro Ala Leu Arg Arg Leu His Thr Ser Ser Trp Arg 
            20                  25                  30          


Ala 
    


<210>  530
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q7Z7H8 mitochondrial targeting peptide

<400>  530

Met Ala Ala Ala Val Ala Gly Met Leu Arg Gly Gly Leu Leu Pro Gln 
1               5                   10                  15      


Ala Gly Arg Leu Pro Thr Leu Gln Thr Val Arg Tyr 
            20                  25              


<210>  531
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q86SX6 mitochondrial targeting peptide

<400>  531

Met Ser Gly Ser Leu Gly Arg Ala Ala Ala Ala Leu Leu Arg Trp Gly 
1               5                   10                  15      


Arg Gly Ala Gly Gly Gly Gly Leu Trp Gly Pro Gly Val Arg Ala 
            20                  25                  30      


<210>  532
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q86TS9 mitochondrial targeting peptide

<400>  532

Met Ala Ala Leu Gly Thr Val Leu Phe Thr Gly Val Arg Arg Leu His 
1               5                   10                  15      


Cys Ser Val Ala Ala Trp Ala 
            20              


<210>  533
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q86U28 mitochondrial targeting peptide

<400>  533

Met Ala Ala Ala Trp Gly Ser Ser 
1               5               


<210>  534
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q86U90 mitochondrial targeting peptide

<400>  534

Met Ser Pro Ala Arg Arg Cys Arg Gly Met Arg Ala Ala Val Ala Ala 
1               5                   10                  15      


Ser Val Gly Leu Ser Glu Gly Pro Ala Gly Ser Arg Ser Gly Arg Leu 
            20                  25                  30          


Phe Arg Pro Pro Ser Pro Ala Pro Ala Ala Pro Gly Ala Arg Leu Leu 
        35                  40                  45              


Arg Leu Pro Gly Ser Gly Ala 
    50                  55  


<210>  535
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q86UT6 mitochondrial targeting peptide

<400>  535

Met Arg Trp Gly His His Leu Pro Arg Ala Ser Trp Gly Ser Gly Phe 
1               5                   10                  15      


Arg Arg Ala Leu Gln Arg Pro Asp Asp Arg Ile Pro Phe Leu Ile His 
            20                  25                  30          


Trp Ser Trp Pro Leu Gln Gly Glu Arg Pro Phe Gly Pro Pro Arg Ala 
        35                  40                  45              


Phe Ile Arg His His Gly Ser Ser Val Asp Ser Ala Pro Pro Pro Gly 
    50                  55                  60                  


Arg His Gly Arg Leu Phe Pro Ser Ala Ser Ala Thr Glu Ala Ile Gln 
65                  70                  75                  80  


Arg His Arg Arg Asn Leu 
                85      


<210>  536
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q86XE5 mitochondrial targeting peptide

<400>  536

Met Leu Gly Pro Gln Val Trp Ser Ser Val Arg Gln Gly Leu Ser Arg 
1               5                   10                  15      


Ser Leu Ser Arg Asn Val Gly Val Trp 
            20                  25  


<210>  537
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q86YB7 mitochondrial targeting peptide

<400>  537

Met Leu Arg Val Leu Cys Leu Leu Arg Pro Trp Arg Pro Leu Arg Ala 
1               5                   10                  15      


Arg Gly Cys Ala Ser Asp Gly Ala Ala Gly Gly Ser Glu Ile Gln Val 
            20                  25                  30          


Arg Ala Leu 
        35  


<210>  538
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8IVH4 mitochondrial targeting peptide

<400>  538

Met Pro Met Leu Leu Pro His Pro His Gln His Phe Leu Lys Gly Leu 
1               5                   10                  15      


Leu Arg Ala Pro Phe Arg Cys Tyr His Phe Ile Phe His Ser Ser Thr 
            20                  25                  30          


His Leu Gly Ser Gly Ile Pro Cys Ala Gln Pro Phe Asn Ser Leu Gly 
        35                  40                  45              


Leu His Cys Thr Lys Trp Met Leu Leu Ser Asp Gly Leu Lys Arg Lys 
    50                  55                  60                  


Leu 
65  


<210>  539
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8IVS2 mitochondrial targeting peptide

<400>  539

Met Ser Val Arg Val Ala Arg Val Ala Trp Val Arg Gly Leu Gly Ala 
1               5                   10                  15      


Ser Tyr Arg Arg Gly 
            20      


<210>  540
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8IWL3 mitochondrial targeting peptide

<400>  540

Met Trp Arg Gly Arg Ala Gly Ala Leu Leu Arg Val Trp Gly Phe Trp 
1               5                   10                  15      


Pro Thr Gly Val Pro Arg Arg Arg Pro Leu Ser Cys Asp 
            20                  25                  


<210>  541
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8IXM3 mitochondrial targeting peptide

<400>  541

Met Gly Val Leu Ala Ala Ala Ala Arg Cys Leu Val Arg 
1               5                   10              


<210>  542
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8IXQ9 mitochondrial targeting peptide

<400>  542

Met Ala Leu Ser Leu Gly Trp Lys Ala His Arg Asn His Cys Gly Leu 
1               5                   10                  15      


Leu Leu Gln Ala Leu Arg Ser Ser Gly Leu Leu Leu Phe Pro Cys Gly 
            20                  25                  30          


Gln Cys Pro Trp Arg Gly 
        35              


<210>  543
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8IYB8 mitochondrial targeting peptide

<400>  543

Met Ser Phe Ser Arg Ala Leu Leu Trp Ala Arg Leu Pro Ala Gly Arg 
1               5                   10                  15      


Gln Ala Gly His Arg Ala 
            20          


<210>  544
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8IYU8 mitochondrial targeting peptide

<400>  544

Met Ala Ala Ala Ala Gly Ser Cys Ala Arg Val Ala Ala Trp Gly Gly 
1               5                   10                  15      


Lys Leu Arg Arg Gly Leu 
            20          


<210>  545
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8N0V3 mitochondrial targeting peptide

<400>  545

Met Trp Ala Ala Ala Gly Gly Leu Trp Arg Ser Arg Ala Gly Leu Arg 
1               5                   10                  15      


Ala Leu Phe Arg Ser Arg Asp Ala Ala Leu Phe Pro Gly Cys Glu Arg 
            20                  25                  30          


Gly Leu His Cys Ser Ala Val Ser Cys 
        35                  40      


<210>  546
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8N0X4 mitochondrial targeting peptide

<400>  546

Met Ala Leu Arg Leu Leu Arg Arg Ala Ala Arg Gly Ala Ala Ala Ala 
1               5                   10                  15      


Ala Leu Leu Arg Leu Lys 
            20          


<210>  547
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8N159 mitochondrial targeting peptide

<400>  547

Met Ala Thr Ala Leu Met Ala Val Val Leu Arg Ala Ala Ala Val Ala 
1               5                   10                  15      


Pro Arg 
        


<210>  548
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8N1F1 mitochondrial targeting peptide

<400>  548

Met Phe Pro Gly Ser Leu Ser Arg Gly Arg Arg Ala Ala Val Glu Met 
1               5                   10                  15      


Ala Trp Leu Pro Gly Ser Cys Ala Arg Val Ala Phe Ala Ala Gly Ala 
            20                  25                  30          


Ala Ala Arg Tyr 
        35      


<210>  549
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8N3J5 mitochondrial targeting peptide

<400>  549

Met Ser Thr Ala Ala Leu Ile Thr Leu Val Arg Ser Gly Gly Asn Gln 
1               5                   10                  15      


Val Arg Arg Arg Val Leu Leu Ser Ser Arg Leu Leu Gln 
            20                  25                  


<210>  550
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8N442 mitochondrial targeting peptide

<400>  550

Met Trp Thr Leu Val Gly Arg Gly Trp Gly Cys Ala Arg Ala Leu Ala 
1               5                   10                  15      


Pro Arg Ala Thr Gly Ala Ala Leu Leu Val Ala Pro Gly Pro Arg Ser 
            20                  25                  30          


Ala Pro Thr Leu Gly Ala Ala Pro Glu Ser Trp Ala Thr Asp Arg Leu 
        35                  40                  45              


Tyr 
    


<210>  551
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8N465 mitochondrial targeting peptide

<400>  551

Met Leu Pro Arg Arg Pro Leu Ala Trp Pro Ala Trp Leu 
1               5                   10              


<210>  552
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8N4E7 mitochondrial targeting peptide

<400>  552

Met Leu Ser Cys Phe Arg Leu Leu Ser Arg His Ile Ser Pro Ser Leu 
1               5                   10                  15      


Ala Ser Leu Arg Pro Val Arg Cys Cys Phe Ala Leu Pro Leu Arg Trp 
            20                  25                  30          


Ala Pro Gly Arg Pro Leu Asp Pro Arg Gln Ile Ala Pro Arg Arg Pro 
        35                  40                  45              


Leu 
    


<210>  553
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8N5M1 mitochondrial targeting peptide

<400>  553

Met Trp Arg Ser Cys Leu Arg Leu Arg Asp Gly Gly Arg Arg Leu Leu 
1               5                   10                  15      


Asn Arg Pro Ala Gly Gly Pro Ser Ala Ser Met Ser Pro Gly Pro Thr 
            20                  25                  30          


Ile Pro Ser Pro Ala Arg Ala Tyr 
        35                  40  


<210>  554
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8N5Z0 mitochondrial targeting peptide

<400>  554

Met Asn Tyr Ala Arg Phe Ile Thr Ala Ala Ser Ala Ala Arg Asn Pro 
1               5                   10                  15      


Ser Pro Ile Arg Thr Met Thr Asp Ile Leu Ser Arg Gly 
            20                  25                  


<210>  555
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8NCN5 mitochondrial targeting peptide

<400>  555

Met Met Phe Tyr Arg Leu Leu Ser Ile Val Gly Arg Gln Arg Ala Ser 
1               5                   10                  15      


Pro Gly Trp Gln Asn Trp Ser Ser Ala Arg Asn 
            20                  25          


<210>  556
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8NCW5 mitochondrial targeting peptide

<400>  556

Met Ser Arg Leu Arg Ala Leu Leu Gly Leu Gly Leu Leu Val Ala Gly 
1               5                   10                  15      


Ser Arg Val Pro Arg Ile Lys Ser Gln Thr Ile Ala Cys Arg Ser Gly 
            20                  25                  30          


Pro Thr Trp Trp Gly Pro Gln Arg Leu Asn Ser Gly Gly Arg Trp 
        35                  40                  45          


<210>  557
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8NE62 mitochondrial targeting peptide

<400>  557

Met Trp Cys Leu Leu Arg Gly Leu Gly Arg Pro Gly Ala Leu Ala Arg 
1               5                   10                  15      


Gly Ala Leu Gly Gln Gln Gln Ser Leu Gly Ala Arg Ala 
            20                  25                  


<210>  558
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8NE86 mitochondrial targeting peptide

<400>  558

Met Ala Ala Ala Ala Gly Arg Ser Leu Leu Leu Leu Leu Ser Ser Arg 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Ala Gly Gly Cys Gly Ala Leu Thr Ala Gly 
            20                  25                  30          


Cys Phe Pro Gly Leu Gly Val Ser Arg His Arg Gln Gln Gln His His 
        35                  40                  45              


Arg Thr 
    50  


<210>  559
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8NFF5 mitochondrial targeting peptide

<400>  559

Met Gly Trp Asp Leu Gly Thr Arg Leu Phe Gln Arg Gln Glu Gln Arg 
1               5                   10                  15      


Ser 
    


<210>  560
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8NI60 mitochondrial targeting peptide

<400>  560

Met Ala Ala Ile Leu Gly Asp Thr Ile Met Val Ala Lys Gly Leu Val 
1               5                   10                  15      


Lys Leu Thr Gln Ala Ala Val Glu Thr His Leu Gln His Leu Gly Ile 
            20                  25                  30          


Gly Gly Glu Leu Ile Met Ala Ala Arg Ala Leu Gln Ser Thr Ala Val 
        35                  40                  45              


Glu Gln Ile Gly Met Phe Leu Gly Lys Val Gln Gly Gln Asp Lys His 
    50                  55                  60                  


Glu Glu Tyr Phe Ala Glu Asn Phe Gly Gly Pro Glu Gly Glu Phe His 
65                  70                  75                  80  


Phe Ser Val Pro His Ala Ala Gly Ala Ser Thr Asp Phe Ser Ser Ala 
                85                  90                  95      


Ser Ala Pro Asp Gln Ser Ala Pro Pro Ser Leu Gly His Ala His Ser 
            100                 105                 110         


Glu Gly Pro Ala Pro Ala Tyr Val Ala Ser Gly Pro Phe Arg Glu Ala 
        115                 120                 125             


Gly Phe Pro Gly Gln Ala Ser Ser Pro Leu Gly Arg Ala Asn Gly Arg 
    130                 135                 140                 


Leu Phe Ala Asn Pro Arg Asp Ser Phe Ser Ala Met Gly Phe Gln Arg 
145                 150                 155                 160 


Arg Phe 
        


<210>  561
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8TAA5 mitochondrial targeting peptide

<400>  561

Met Ala Val Arg Ser Leu Trp Ala Gly Arg Leu Arg Val Gln Arg Leu 
1               5                   10                  15      


Leu Ala Trp Ser Ala Ala Trp Glu Ser Lys Gly Trp Pro Leu Pro Phe 
            20                  25                  30          


<210>  562
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8TB37 mitochondrial targeting peptide

<400>  562

Met Gly Ile Trp Gln Arg Leu Leu Leu Phe Gly Gly Val Ser Leu Arg 
1               5                   10                  15      


Ala Gly Gly Gly Ala Thr Ala Pro Leu Gly Gly Ser Arg Ala Met Val 
            20                  25                  30          


Cys Gly Arg Gln Leu Ser 
        35              


<210>  563
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8TCC3 mitochondrial targeting peptide

<400>  563

Met Ala Gly Ile Leu Arg Leu Val Val Gln Trp Pro Pro Gly Arg Leu 
1               5                   10                  15      


Gln Thr Val Thr Lys Gly Val Glu Ser Leu Ile Cys Thr Asp Trp Ile 
            20                  25                  30          


Arg His 
        


<210>  564
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8TCS8 mitochondrial targeting peptide

<400>  564

Met Ala Ala Cys Arg Tyr Cys Cys Ser Cys Leu Arg Leu Arg Pro Leu 
1               5                   10                  15      


Ser Asp Gly Pro Phe Leu Leu Pro Arg Arg Asp Arg Ala Leu Thr Gln 
            20                  25                  30          


Leu Gln Val Arg Ala Leu Trp Ser Ser Ala Gly Ser Arg 
        35                  40                  45  


<210>  565
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8TF08 mitochondrial targeting peptide

<400>  565

Met Met Phe Pro Leu Ala Arg Asn Ala Leu Ser Ser Leu Lys Ile Gln 
1               5                   10                  15      


Ser Ile Leu Gln Ser Met Ala Arg His 
            20                  25  


<210>  566
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8WUK0 mitochondrial targeting peptide

<400>  566

Met Ala Ala Thr Ala Leu Leu Glu Ala Gly Leu Ala Arg Val Leu Phe 
1               5                   10                  15      


Tyr Pro Thr Leu Leu Tyr Thr Leu Phe Arg Gly 
            20                  25          


<210>  567
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8WVM0 mitochondrial targeting peptide

<400>  567

Met Ala Ala Ser Gly Lys Leu Ser Thr Cys Arg Leu Pro Pro Leu Pro 
1               5                   10                  15      


Thr Ile Arg Glu Ile Ile Lys Leu Leu Arg Leu 
            20                  25          


<210>  568
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8WWC4 mitochondrial targeting peptide

<400>  568

Met Ala Leu Ala Ala Arg Leu Leu Pro Gln Phe Leu His Ser Arg Ser 
1               5                   10                  15      


Leu Pro Cys Gly Ala Val Arg Leu Arg Thr Pro Ala Val Ala Glu Val 
            20                  25                  30          


Arg Leu Pro Ser Ala Thr Leu Cys Tyr Phe Cys Arg Cys Arg Leu Gly 
        35                  40                  45              


Leu Gly Ala Ala Leu Phe Pro Arg Ser Ala Arg Ala Leu Ala Ala Ser 
    50                  55                  60                  


Ala Leu Pro Ala Gln Gly Ser Arg Trp Pro Val Leu Ser Ser Pro Gly 
65                  70                  75                  80  


Leu Pro Ala Ala Phe Ala Ser Phe Pro Ala Cys Pro Gln Arg Ser Tyr 
                85                  90                  95      


<210>  569
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8WWV3 mitochondrial targeting peptide

<400>  569

Met Glu Phe Leu Lys Thr Cys Val Leu Arg Arg Asn Ala Cys Thr Ala 
1               5                   10                  15      


Val Cys Phe Trp Arg Ser Lys Val Val Gln Lys Pro Ser Val Arg Arg 
            20                  25                  30          


Ile Ser Thr Thr Ser Pro Arg Ser 
        35                  40  


<210>  570
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8WYQ3 mitochondrial targeting peptide

<400>  570

Met Pro Arg Gly Ser Arg Ser Ala Ala Ser Arg Pro Ala Ser Arg Pro 
1               5                   10                  15      


<210>  571
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q92665 mitochondrial targeting peptide

<400>  571

Met Phe Pro Arg Val Ser Thr Phe Leu Pro Leu Arg Pro Leu Ser Arg 
1               5                   10                  15      


His Pro Leu Ser Ser Gly Ser Pro Glu Thr Ser Ala Ala Ala Ile Met 
            20                  25                  30          


Leu Leu Thr Val Arg His Gly Thr Val Arg Tyr Arg Ser Ser Ala Leu 
        35                  40                  45              


Leu Ala Arg Thr Lys Asn Asn Ile Gln Arg Tyr Phe Gly Thr Asn Ser 
    50                  55                  60                  


Val 
65  


<210>  572
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q92667 mitochondrial targeting peptide

<400>  572

Met Ala Ile Gln Phe Arg Ser Leu Phe Pro Leu Ala Leu Pro Gly Met 
1               5                   10                  15      


Leu Ala Leu Leu Gly Trp Trp Trp Phe Phe Ser Arg Lys 
            20                  25                  


<210>  573
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q92947 mitochondrial targeting peptide

<400>  573

Met Ala Leu Arg Gly Val Ser Val Arg Leu Leu Ser Arg Gly Pro Gly 
1               5                   10                  15      


Leu His Val Leu Arg Thr Trp Val Ser Ser Ala Ala Gln Thr Glu Lys 
            20                  25                  30          


Gly Gly Arg Thr Gln Ser Gln Leu Ala Lys Ser Ser 
        35                  40                  


<210>  574
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q969P6 mitochondrial targeting peptide

<400>  574

Met Arg Val Val Arg Leu Leu Arg Leu Arg Ala Ala Leu Thr Leu Leu 
1               5                   10                  15      


Gly Glu Val Pro Arg Arg Pro Ala Ser Arg Gly Val Pro Gly Ser Arg 
            20                  25                  30          


Arg Thr Gln Lys Gly Ser Gly Ala Arg Trp Glu Lys Glu Lys His Glu 
        35                  40                  45              


Asp Gly 
    50  


<210>  575
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q969Y2 mitochondrial targeting peptide

<400>  575

Met Trp Arg Gly Leu Trp Thr Leu Ala Ala Gln Ala Ala Arg Gly Pro 
1               5                   10                  15      


Arg Arg Leu Cys Thr Arg Arg Ser Ser Gly Ala Pro Ala Pro Gly Ser 
            20                  25                  30          


Gly Ala Thr Ile Phe Ala Leu Ser Ser Gly Gln Gly Arg Cys Gly Ile 
        35                  40                  45              


Ala Val Ile Arg Thr Ser Gly Pro Ala Ser Gly His Ala Leu Arg Ile 
    50                  55                  60                  


Leu Thr Ala Pro Arg Asp Leu Pro Leu Ala Arg His Ala Ser Leu Arg 
65                  70                  75                  80  


Leu 
    


<210>  576
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q969Z0 mitochondrial targeting peptide

<400>  576

Met Ala Ala His Leu Val Lys Arg Cys Thr Cys Leu Leu Arg Glu Ala 
1               5                   10                  15      


Ala Arg Gln Ala Pro Ala Met Ala Pro Val Gly Arg Leu Arg Leu Ala 
            20                  25                  30          


Trp Val Ala His Lys Thr Leu Thr Ser Ser Ala Thr Ser Pro Ile Ser 
        35                  40                  45              


His Leu Pro Gly Ser Leu Met Glu Pro Val Glu Lys Glu Arg Ala Ser 
    50                  55                  60                  


Thr Pro Tyr Ile Glu Lys Gln Val Asp His Leu Ile Lys Lys Ala Thr 
65                  70                  75                  80  


Arg Pro Glu Glu Leu Leu Glu Leu Leu Gly Gly Ser His Asp Leu Asp 
                85                  90                  95      


Ser Asn Gln Ala Ala Met Val Leu Ile Arg Leu 
            100                 105         


<210>  577
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q969Z3 mitochondrial targeting peptide

<400>  577

Met Gly Ala Ser Ser Ser Ser Ala Leu Ala Arg Leu Gly Leu Pro Ala 
1               5                   10                  15      


Arg Pro Trp Pro Arg Trp Leu Gly Val Ala Ala Leu Gly Leu Ala Ala 
            20                  25                  30          


Val Ala Leu 
        35  


<210>  578
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q96A35 mitochondrial targeting peptide

<400>  578

Met Arg Leu Ser Ala Leu Leu Ala Leu 
1               5                   


<210>  579
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q96BW9 mitochondrial targeting peptide

<400>  579

Met Ala Leu Gln Thr Leu Gln Ser Ser Trp Val Thr Phe Arg Lys Ile 
1               5                   10                  15      


Leu Ser His Phe Pro Glu Glu Leu 
            20                  


<210>  580
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q96CB9 mitochondrial targeting peptide

<400>  580

Met Ala Ala Leu Thr Leu Arg Gly Val Arg Glu Leu Leu Lys Arg Val 
1               5                   10                  15      


Asp Leu Ala Thr Val Pro Arg Arg His 
            20                  25  


<210>  581
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q96CM8 mitochondrial targeting peptide

<400>  581

Met Ala Val Tyr Val Gly Met Leu Arg Leu Gly Arg Leu Cys Ala Gly 
1               5                   10                  15      


Ser Ser Gly Val Leu Gly Ala Arg Ala Ala Leu Ser Arg Ser Trp Gln 
            20                  25                  30          


Glu Ala Arg Leu Gln Gly Val Arg Phe 
        35                  40      


<210>  582
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q96DC8 mitochondrial targeting peptide

<400>  582

Met Ala Ala Val Ala Val Leu Arg Ala Phe Gly Ala Ser Gly Pro Met 
1               5                   10                  15      


Cys 
    


<210>  583
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q96DV4 mitochondrial targeting peptide

<400>  583

Met Ala Ala Pro Trp Trp Arg Ala Ala Leu Cys Glu Cys Arg Arg Trp 
1               5                   10                  15      


Arg Gly Phe Ser Thr Ser Ala Val Leu Gly 
            20                  25      


<210>  584
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q96E11 mitochondrial targeting peptide

<400>  584

Met Ala Leu Gly Leu Lys Cys Phe Arg Met Val His Pro Thr Phe Arg 
1               5                   10                  15      


Asn Tyr Leu Ala Ala Ser Ile Arg Pro Val Ser Glu Val Thr Leu Lys 
            20                  25                  30          


Thr Val His Glu Arg Gln His Gly His Arg Gln Tyr Met Ala Tyr Ser 
        35                  40                  45              


Ala Val Pro Val Arg His Phe 
    50                  55  


<210>  585
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q96E29 mitochondrial targeting peptide

<400>  585

Met Ala Leu Ser Ala Gln Gln Ile Pro Arg Trp Phe Asn Ser Val Lys 
1               5                   10                  15      


Leu Arg Ser Leu Ile Asn Ala Ala Gln Leu Thr Lys Arg Phe Thr Arg 
            20                  25                  30          


Pro Ala Arg Thr Leu Leu His Gly Phe Ser Ala Gln Pro Gln Ile Ser 
        35                  40                  45              


Ser Asp Asn Cys Phe Leu Gln Trp Gly Phe Lys Thr Tyr Arg Thr Ser 
    50                  55                  60                  


Ser Leu Trp Asn 
65              


<210>  586
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q96E52 mitochondrial targeting peptide

<400>  586

Met Ser Phe Ile Cys Gly Leu Gln Ser Ala Ala Arg Asn 
1               5                   10              


<210>  587
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q96EL2 mitochondrial targeting peptide

<400>  587

Met Ala Ala Ser Val Cys Ser Gly Leu Leu Gly Pro Arg Val Leu Ser 
1               5                   10                  15      


Trp Ser Arg Glu Leu Pro Cys Ala Trp Arg Ala Leu His Thr Ser Pro 
            20                  25                  30          


Val Cys Ala 
        35  


<210>  588
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q96EY7 mitochondrial targeting peptide

<400>  588

Met Ala Val Val Ser Ala Val Arg Trp Leu Gly Leu Arg Ser Arg Leu 
1               5                   10                  15      


Gly Gln Pro Leu Thr Gly Arg Arg Ala Gly Leu Cys Glu Gln Ala Arg 
            20                  25                  30          


Ser Cys Arg Phe Tyr 
        35          


<210>  589
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q96EY8 mitochondrial targeting peptide

<400>  589

Met Ala Val Cys Gly Leu Gly Ser Arg Leu Gly Leu Gly Ser Arg Leu 
1               5                   10                  15      


Gly Leu Arg Gly Cys Phe Gly Ala Ala Arg Leu Leu Tyr Pro Arg Phe 
            20                  25                  30          


<210>  590
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q96GC5 mitochondrial targeting peptide

<400>  590

Met Ser Gly Thr Leu Glu Lys Val Leu Cys Leu Arg Asn Asn Thr Ile 
1               5                   10                  15      


Phe Lys Gln Ala Phe Ser Leu Leu Arg Phe Arg Thr 
            20                  25              


<210>  591
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q96GW9 mitochondrial targeting peptide

<400>  591

Met Leu Arg Thr Ser Val Leu Arg Leu Leu Gly Arg Thr Gly Ala Ser 
1               5                   10                  15      


Arg Leu Ser Leu Leu Glu Asp Phe Gly Pro Arg Tyr Tyr 
            20                  25                  


<210>  592
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q96H96 mitochondrial targeting peptide

<400>  592

Met Leu Gly Ser Arg Ala Ala Gly Phe Ala Arg Gly Leu Arg Ala Leu 
1               5                   10                  15      


Ala Leu Ala Trp Leu Pro Gly Trp Arg Gly Arg Ser Phe Ala Leu Ala 
            20                  25                  30          


Arg Ala 
        


<210>  593
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q96I23 mitochondrial targeting peptide

<400>  593

Met Leu Ser Gly Ala Arg Cys Arg Leu Ala Ser Ala Leu Arg Gly Thr 
1               5                   10                  15      


Arg Ala Pro Pro Ser Ala Val Ala Arg Arg Cys Leu His Ala Ser Gly 
            20                  25                  30          


Ser Arg Pro 
        35  


<210>  594
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q96I59 mitochondrial targeting peptide

<400>  594

Met Leu Gly Val Arg Cys Leu Leu Arg Ser Val Arg Phe Cys 
1               5                   10                  


<210>  595
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q96I99 mitochondrial targeting peptide

<400>  595

Met Ala Ser Pro Val Ala Ala Gln Ala Gly Lys Leu Leu Arg Ala Leu 
1               5                   10                  15      


Ala Leu Arg Pro Arg Phe Leu Ala Ala Gly Ser Gln Ala Val Gln Leu 
            20                  25                  30          


Thr Ser Arg Arg Trp 
        35          


<210>  596
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q96IL0 mitochondrial targeting peptide

<400>  596

Met Leu Pro Cys Ala Ala Gly Ala Arg Gly Arg Gly Ala Met Val Val 
1               5                   10                  15      


Leu Arg Ala Gly Lys Lys Thr Phe Leu Pro Pro Leu Cys Arg Ala Phe 
            20                  25                  30          


Ala Cys Arg Gly Cys Gln Leu 
        35                  


<210>  597
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q96MF6 mitochondrial targeting peptide

<400>  597

Met Ala Trp Ala Gly Ser Arg Arg Val Pro Ala Gly Thr Arg Ala 
1               5                   10                  15  


<210>  598
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q96PE7 mitochondrial targeting peptide

<400>  598

Met Ala Arg Val Leu Lys Ala Ala Ala Ala Asn Ala Val Gly Leu Phe 
1               5                   10                  15      


Ser Arg Leu Gln Ala Pro Ile Pro Thr Val Arg Ala Ser Ser Thr Ser 
            20                  25                  30          


Gln Pro Leu Asp 
        35      


<210>  599
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q96Q11 mitochondrial targeting peptide

<400>  599

Met Leu Arg Cys Leu Tyr His Trp His Arg Pro Val Leu Asn Arg Arg 
1               5                   10                  15      


Trp Ser Arg Leu Cys Leu Pro Lys Gln Tyr Leu Phe Thr Met Lys Leu 
            20                  25                  30          


Gln Ser Pro Glu Phe Gln Ser Leu Phe 
        35                  40      


<210>  600
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q96QE5 mitochondrial targeting peptide

<400>  600

Met Ser Gly Ser Val Leu Phe Thr Ala Gly Glu Arg Trp Arg Cys Phe 
1               5                   10                  15      


Leu Thr Pro Ser Arg Ser Ser Leu Tyr Trp Ala Leu His Asn Phe Cys 
            20                  25                  30          


Cys Arg Lys 
        35  


<210>  601
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q96RP9 mitochondrial targeting peptide

<400>  601

Met Arg Leu Leu Gly Ala Ala Ala Val Ala Ala Leu Gly Arg Gly Arg 
1               5                   10                  15      


Ala Pro Ala Ser Leu Gly Trp Gln Arg Lys Gln Val Asn Trp Lys Ala 
            20                  25                  30          


Cys Arg Trp Ser 
        35      


<210>  602
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q96RQ3 mitochondrial targeting peptide

<400>  602

Met Ala Ala Ala Ser Ala Val Ser Val Leu Leu Val Ala Ala Glu Arg 
1               5                   10                  15      


Asn Arg Trp His Arg Leu Pro Ser Leu Leu Leu Pro Pro Arg Thr Trp 
            20                  25                  30          


Val Trp Arg Gln Arg Thr Met Lys Tyr 
        35                  40      


<210>  603
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q96RR1 mitochondrial targeting peptide

<400>  603

Met Trp Val Leu Leu Arg Ser Gly Tyr Pro Leu Arg Ile Leu Leu Pro 
1               5                   10                  15      


Leu Arg Gly Glu Trp Met Gly Arg Arg Gly Leu Pro Arg Asn Leu 
            20                  25                  30      


<210>  604
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q99551 mitochondrial targeting peptide

<400>  604

Met Gln Ser Leu Ser Leu Gly Gln Thr Ser Ile Ser Lys Gly Leu Asn 
1               5                   10                  15      


Tyr Leu Thr Ile Met Ala Pro Gly Asn Leu Trp His Met Arg Asn Asn 
            20                  25                  30          


Phe Leu Phe Gly Ser Arg Cys Trp Met Thr Arg Phe Ser Ala Glu Asn 
        35                  40                  45              


Ile Phe Lys Ser Val Ser Phe Arg Leu 
    50                  55          


<210>  605
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q99643 mitochondrial targeting peptide

<400>  605

Met Ala Ala Leu Leu Leu Arg His Val Gly Arg His Cys Leu Arg Ala 
1               5                   10                  15      


His Phe Ser Pro Gln Leu Cys Ile Arg Asn Ala Val Pro 
            20                  25                  


<210>  606
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q99757 mitochondrial targeting peptide

<400>  606

Met Ala Gln Arg Leu Leu Leu Arg Arg Phe Leu Ala Ser Val Ile Ser 
1               5                   10                  15      


Arg Lys Pro Ser Gln Gly Gln Trp Pro Pro Leu Thr Ser Arg Ala Leu 
            20                  25                  30          


Gln Thr Pro Gln Cys Ser Pro Gly Gly Leu Thr Val Thr Pro Asn Pro 
        35                  40                  45              


Ala Arg Thr Ile Tyr Thr Thr Arg Ile Ser Leu 
    50                  55                  


<210>  607
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q99766 mitochondrial targeting peptide

<400>  607

Met Cys Cys Ala Val Ser Glu Gln Arg Leu Thr Cys Ala Asp Gln Met 
1               5                   10                  15      


Met Pro Phe Gly Lys Ile Ser Gln Gln Leu Cys Gly Val Lys Lys Leu 
            20                  25                  30          


Pro Trp Ser Cys Asp Ser Arg Tyr 
        35                  40  


<210>  608
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q99797 mitochondrial targeting peptide

<400>  608

Met Leu Cys Val Gly Arg Leu Gly Gly Leu Gly Ala Arg Ala Ala Ala 
1               5                   10                  15      


Leu Pro Pro Arg Arg Ala Gly Arg Gly Ser Leu Glu Ala Gly Ile Arg 
            20                  25                  30          


Ala Arg Arg 
        35  


<210>  609
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q99798 mitochondrial targeting peptide

<400>  609

Met Ala Pro Tyr Ser Leu Leu Val Thr Arg Leu Gln Lys Ala Leu Gly 
1               5                   10                  15      


Val Arg Gln Tyr His Val Ala Ser Val Leu Cys 
            20                  25          


<210>  610
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q99807 mitochondrial targeting peptide

<400>  610

Met Ser Cys Ala Gly Ala Ala Ala Ala Pro Arg Leu Trp Arg Leu Arg 
1               5                   10                  15      


Pro Gly Ala Arg Arg Ser Leu Ser Ala Tyr Gly Arg Arg Thr Ser Val 
            20                  25                  30          


Arg Phe Arg 
        35  


<210>  611
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9BQ52 mitochondrial targeting peptide

<400>  611

Met Trp Ala Leu Cys Ser Leu Leu Arg Ser Ala Ala Gly Arg Thr Met 
1               5                   10                  15      


<210>  612
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9BQ95 mitochondrial targeting peptide

<400>  612

Met Ser Trp Val Gln Ala Thr Leu Leu Ala Arg Gly Leu Cys Arg Ala 
1               5                   10                  15      


Trp Gly Gly Thr Cys Gly Ala Ala Leu Thr Gly Thr Ser Ile Ser Gln 
            20                  25                  30          


Val Pro Arg Arg Leu Pro Arg Gly Leu His Cys Ser Ala Ala Ala His 
        35                  40                  45              


<210>  613
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9BRT2 mitochondrial targeting peptide

<400>  613

Met Ala Ala Ser Arg Tyr Arg Arg Phe Leu Lys Leu Cys 
1               5                   10              


<210>  614
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9BSE5 mitochondrial targeting peptide

<400>  614

Met Leu Arg Leu Leu Ala Ser Gly Cys Ala Arg Gly Pro Gly Pro Gly 
1               5                   10                  15      


Val Gly Ala Arg Pro Ala Ala Gly Leu Phe His Pro Gly Arg Arg Gln 
            20                  25                  30          


Ser Arg Gln 
        35  


<210>  615
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9BT30 mitochondrial targeting peptide

<400>  615

Met Ala Gly Thr Gly Leu Leu Ala Leu Arg Thr Leu Pro Gly Pro Ser 
1               5                   10                  15      


Trp Val Arg Gly 
            20  


<210>  616
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9BUB7 mitochondrial targeting peptide

<400>  616

Met Leu Phe Leu Ala Leu Gly Ser Pro Trp Ala Val Glu Leu Pro Leu 
1               5                   10                  15      


Cys Gly Arg Arg Thr Ala Leu Cys Ala Ala Ala Ala Leu Arg Gly Pro 
            20                  25                  30          


Arg Ala Ser Val Ser Arg Ala Ser Ser Ser Ser Gly Pro Ser Gly Pro 
        35                  40                  45              


Val Ala Gly Trp Ser Thr Gly Pro Ser Gly Ala Ala Arg Leu Leu Arg 
    50                  55                  60                  


Arg Pro Gly Arg Ala Gln Ile Pro Val Tyr Trp Glu Gly Tyr Val Arg 
65                  70                  75                  80  


Phe 
    


<210>  617
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9BUE6 mitochondrial targeting peptide

<400>  617

Met Ser Ala Ser Leu Val Arg Ala Thr Val Arg Ala 
1               5                   10          


<210>  618
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9BV79 mitochondrial targeting peptide

<400>  618

Met Trp Val Cys Ser Thr Leu Trp Arg Val Arg Thr Pro Ala Arg Gln 
1               5                   10                  15      


Trp Arg Gly Leu Leu Pro Ala Ser Gly Cys His Gly Pro Ala Ala Ser 
            20                  25                  30          


Ser Tyr Ser Ala Ser Ala Glu Pro Ala Arg Val Arg Ala Leu Val Tyr 
        35                  40                  45              


Gly His His Gly Asp 
    50              


<210>  619
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9BVV7 mitochondrial targeting peptide

<400>  619

Met Ile Cys Thr Phe Leu Arg Ala Val Gln Tyr Thr Glu Lys Leu His 
1               5                   10                  15      


Arg Ser 
        


<210>  620
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9BW91 mitochondrial targeting peptide

<400>  620

Met Ala Gly Arg Leu Leu Gly Lys Ala Leu Ala Ala Val Ser Leu Ser 
1               5                   10                  15      


Leu Ala Leu Ala Ser Val Thr Ile Arg Ser Ser Arg Cys Arg Gly Ile 
            20                  25                  30          


Gln Ala Phe Arg Asn Ser Phe Ser Ser Ser Trp Phe His Leu 
        35                  40                  45      


<210>  621
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9BX68 mitochondrial targeting peptide

<400>  621

Met Ala Ala Ala Val Val Leu Ala Ala Gly Leu Arg Ala Ala Arg Arg 
1               5                   10                  15      


Ala 
    


<210>  622
<211>  77
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9BXM7 mitochondrial targeting peptide

<400>  622

Met Ala Val Arg Gln Ala Leu Gly Arg Gly Leu Gln Leu Gly Arg Ala 
1               5                   10                  15      


Leu Leu Leu Arg Phe Thr Gly Lys Pro Gly Arg Ala Tyr Gly Leu Gly 
            20                  25                  30          


Arg Pro Gly Pro Ala Ala Gly Cys Val Arg Gly Glu Arg Pro Gly Trp 
        35                  40                  45              


Ala Ala Gly Pro Gly Ala Glu Pro Arg Arg Val Gly Leu Gly Leu Pro 
    50                  55                  60                  


Asn Arg Leu Arg Phe Phe Arg Gln Ser Val Ala Gly Leu 
65                  70                  75          


<210>  623
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9BYC2 mitochondrial targeting peptide

<400>  623

Met Ala Ala Leu Arg Leu Leu Ala Ser Val Leu Gly Arg Gly Val Pro 
1               5                   10                  15      


Ala Gly Gly Ser Gly Leu Ala Leu Ser Gln Gly Cys Ala Arg Cys Phe 
            20                  25                  30          


Ala Thr Ser Pro Arg Leu Arg 
        35                  


<210>  624
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9BYC9 mitochondrial targeting peptide

<400>  624

Met Val Phe Leu Thr Ala Gln Leu Trp Leu Arg Asn Arg Val Thr Asp 
1               5                   10                  15      


Arg Tyr Phe Arg Ile Gln Glu Val Leu Lys His Ala Arg His Phe Arg 
            20                  25                  30          


Gly Arg Lys Asn Arg Cys Tyr Arg Leu Ala Val Arg Thr 
        35                  40                  45  


<210>  625
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9BYD6 mitochondrial targeting peptide

<400>  625

Met Ala Ala Ala Val Arg Cys Met Gly Arg Ala Leu Ile His His Gln 
1               5                   10                  15      


Arg His Ser Leu Ser Lys Met Val Tyr Gln Thr Ser Leu Cys Ser Cys 
            20                  25                  30          


Ser Val Asn Ile Arg Val Pro Asn Arg His Phe Ala Ala Ala Thr Lys 
        35                  40                  45              


Ser Ala 
    50  


<210>  626
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9BYN8 mitochondrial targeting peptide

<400>  626

Met Leu Arg Ala Leu Ser Arg Leu Gly Ala Gly Thr Pro Cys Arg Pro 
1               5                   10                  15      


Arg Ala Pro Leu Val Leu Pro Ala Arg Gly Arg 
            20                  25          


<210>  627
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9BYT8 mitochondrial targeting peptide

<400>  627

Met Ile Ala Arg Cys Leu Leu Ala Val Arg Ser Leu Arg Arg Val Gly 
1               5                   10                  15      


Gly Ser Arg Ile Leu Leu Arg Met Thr Leu Gly Arg Glu Val Met Ser 
            20                  25                  30          


Pro Leu Gln Ala Met 
        35          


<210>  628
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9BYV1 mitochondrial targeting peptide

<400>  628

Met Thr Leu Ile Trp Arg His Leu Leu Arg Pro Leu Cys Leu Val Thr 
1               5                   10                  15      


Ser Ala Pro Arg Ile Leu Glu Met His Pro Phe Leu Ser Leu Gly Thr 
            20                  25                  30          


Ser Arg Thr Ser Val Thr Lys Leu Ser 
        35                  40      


<210>  629
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9BZ23 mitochondrial targeting peptide

<400>  629

Met Arg Arg Leu Gly Pro Phe His Pro Arg Val His Trp Ala Ala Pro 
1               5                   10                  15      


Pro Ser Leu Ser Ser Gly Leu His Arg Leu Leu Phe Leu Arg Gly Thr 
            20                  25                  30          


Arg Ile Pro Ser Ser Thr Thr Leu Ser Pro Pro Arg His Asp 
        35                  40                  45      


<210>  630
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9BZE1 mitochondrial targeting peptide

<400>  630

Met Ala Leu Ala Ser Gly Pro Ala Arg Arg Ala Leu Ala Gly Ser Gly 
1               5                   10                  15      


Gln Leu Gly Leu Gly Gly Phe Gly Ala Pro Arg Arg Gly 
            20                  25                  


<210>  631
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9GZT6 mitochondrial targeting peptide

<400>  631

Met Asn Ser Arg Gln Ala Trp Arg Leu Phe Leu Ser Gln Gly Arg Gly 
1               5                   10                  15      


Asp Arg Trp Val Ser Arg Pro Arg Gly His Phe Ser Pro Ala Leu Arg 
            20                  25                  30          


Arg Glu Phe Phe Thr Thr Thr Thr Lys Glu 
        35                  40          


<210>  632
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9H078 mitochondrial targeting peptide

<400>  632

Met Leu Gly Ser Leu Val Leu Arg Arg Lys Ala Leu Ala Pro Arg Leu 
1               5                   10                  15      


Leu Leu Arg Leu Leu Arg Ser Pro Thr Leu Arg Gly His Gly Gly Ala 
            20                  25                  30          


Ser Gly Arg Asn 
        35      


<210>  633
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9H1K1 mitochondrial targeting peptide

<400>  633

Met Ala Ala Ala Gly Ala Phe Arg Leu Arg Arg Ala Ala Ser Ala Leu 
1               5                   10                  15      


Leu Leu Arg Ser Pro Arg Leu Pro Ala Arg Glu Leu Ser Ala Pro Ala 
            20                  25                  30          


Arg Leu 
        


<210>  634
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9H2K0 mitochondrial targeting peptide

<400>  634

Met Ala Ala Leu Phe Leu Lys Arg Leu Thr Leu Gln Thr Val Lys Ser 
1               5                   10                  15      


Glu Asn Ser Cys Ile Arg Cys Phe Gly Lys His Ile Leu Gln Lys 
            20                  25                  30      


<210>  635
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9H2U2 mitochondrial targeting peptide

<400>  635

Met Ser Ala Leu Leu Arg Leu Leu Arg Thr Gly Ala Pro Ala Ala Ala 
1               5                   10                  15      


Cys Leu Arg Leu Gly Thr Ser Ala Gly Thr Gly Ser Arg Arg Ala Met 
            20                  25                  30          


<210>  636
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9H300 mitochondrial targeting peptide

<400>  636

Met Ala Trp Arg Gly Trp Ala Gln Arg Gly Trp Gly Cys Gly Gln Ala 
1               5                   10                  15      


Trp Gly Ala Ser Val Gly Gly Arg Ser Cys Glu Glu Leu Thr Ala Val 
            20                  25                  30          


Leu Thr Pro Pro Gln Leu Leu Gly Arg Arg Phe Asn Phe Phe Ile Gln 
        35                  40                  45              


Gln Lys Cys Gly 
    50          


<210>  637
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9H3H1 mitochondrial targeting peptide

<400>  637

Met Ala Ser Val Ala Ala Ala Arg Ala Val Pro Val Gly Ser Gly Leu 
1               5                   10                  15      


Arg Gly Leu Gln Arg Thr Leu Pro Leu Val Val Ile Leu Gly Ala Thr 
            20                  25                  30          


Gly Thr Gly Lys Ser Thr Leu Ala Leu Gln Leu Gly Gln Arg Leu 
        35                  40                  45          


<210>  638
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9H3J6 mitochondrial targeting peptide

<400>  638

Met Ser Thr Val Gly Leu Phe His Phe Pro Thr Pro Leu Thr Arg Ile 
1               5                   10                  15      


Cys Pro Ala Pro Trp Gly Leu Arg Leu Trp Glu Lys Leu Thr Leu Leu 
            20                  25                  30          


Ser Pro Gly 
        35  


<210>  639
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9H3K2 mitochondrial targeting peptide

<400>  639

Met Leu Ala Ala Arg Leu Val Cys Leu Arg Thr Leu Pro Ser Arg Val 
1               5                   10                  15      


Phe His Pro Ala Phe Thr Lys Ala Ser Pro Val Val Lys Asn Ser Ile 
            20                  25                  30          


Thr Lys Asn Gln Trp Leu Leu Thr Pro Ser Arg Glu 
        35                  40                  


<210>  640
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9H3L0 mitochondrial targeting peptide

<400>  640

Met Ala Asn Val Leu Cys Asn Arg Ala Arg Leu Val Ser Tyr Leu Pro 
1               5                   10                  15      


Gly Phe Cys Ser Leu Val Lys Arg Val Val Asn Pro Lys Ala Phe Ser 
            20                  25                  30          


Thr Ala Gly Ser Ser Gly 
        35              


<210>  641
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9H4B0 mitochondrial targeting peptide

<400>  641

Met Leu Ile Leu Thr Lys Thr Ala Gly Val Phe Phe Lys Pro Ser Lys 
1               5                   10                  15      


Arg Lys Val Tyr Glu Phe Leu Arg Ser Phe Asn Phe His 
            20                  25                  


<210>  642
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9H4I9 mitochondrial targeting peptide

<400>  642

Met Ala Ser Gly Ala Ala Arg Trp Leu Val Leu Ala Pro Val Arg Ser 
1               5                   10                  15      


Gly Ala Leu Arg Ser Gly Pro Ser Leu Arg Lys Asp Gly Asp Val Ser 
            20                  25                  30          


Ala Ala Trp Ser Gly Ser Gly Arg Ser Leu Val Pro Ser Arg Ser 
        35                  40                  45          


<210>  643
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9H5Q4 mitochondrial targeting peptide

<400>  643

Met Trp Ile Pro Val Val Gly Leu Pro Arg Arg Leu Arg Leu Ser Ala 
1               5                   10                  15      


Leu Ala Gly 
            


<210>  644
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9H6R3 mitochondrial targeting peptide

<400>  644

Met Lys Pro Ser Trp Leu Gln Cys Arg Lys Val Thr Ser Ala Gly Gly 
1               5                   10                  15      


Leu Gly Gly Pro Leu Pro Gly Ser Ser Pro Ala Arg Gly 
            20                  25                  


<210>  645
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9H7H0 mitochondrial targeting peptide

<400>  645

Met Ala Ala Ala Leu Lys Cys Leu Leu Thr Leu Gly Arg Trp Cys Pro 
1               5                   10                  15      


Gly Leu Gly 
            


<210>  646
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9H8M1 mitochondrial targeting peptide

<400>  646

Met Ala Ala Arg Thr Gly His Thr Ala Leu Arg Arg Val Val Ser Gly 
1               5                   10                  15      


Cys Arg Pro Lys Ser Ala Thr Ala Ala Gly Ala Gln Ala Pro Val Arg 
            20                  25                  30          


Asn Gly Arg Tyr Leu 
        35          


<210>  647
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9H9J2 mitochondrial targeting peptide

<400>  647

Met Ala Ser Gly Leu Val Arg Leu Leu Gln Gln Gly His Arg Cys Leu 
1               5                   10                  15      


Leu Ala Pro Val Ala Pro Lys Leu Val Pro Pro Val Arg Gly 
            20                  25                  30  


<210>  648
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9H9P8 mitochondrial targeting peptide

<400>  648

Met Val Pro Ala Leu Arg Tyr Leu Val Gly Ala Cys Gly Arg Ala Arg 
1               5                   10                  15      


Gly Leu Phe Ala Gly Gly Ser Pro Gly Ala Cys Gly Phe Ala Ser Gly 
            20                  25                  30          


Arg Pro Arg Pro Leu Cys Gly Gly Ser Arg Ser Ala Ser Thr Ser Ser 
        35                  40                  45              


Phe Asp Ile 
    50      


<210>  649
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9HA92 mitochondrial targeting peptide

<400>  649

Met Ala Leu Pro Gly Ala Arg Ala Arg Gly Trp Ala Ala Ala Ala Arg 
1               5                   10                  15      


Ala 
    


<210>  650
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9HAC7 mitochondrial targeting peptide

<400>  650

Met Pro Ser Glu Thr His Ala Met Leu Ala Thr Leu Ala Arg Val Ala 
1               5                   10                  15      


Ala Leu Arg Arg Thr Cys Leu Phe Ser Gly Arg Gly Gly Gly Arg Gly 
            20                  25                  30          


Leu Trp Thr Gly Arg Pro 
        35              


<210>  651
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9HAV7 mitochondrial targeting peptide

<400>  651

Met Ala Ala Gln Cys Val Arg Leu Ala Arg Arg Ser Leu Pro Ala Leu 
1               5                   10                  15      


Ala Leu Ser Leu Arg Pro Ser Pro Arg Leu Leu 
            20                  25          


<210>  652
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9HB07 mitochondrial targeting peptide

<400>  652

Met Gly His Gln Phe Leu Arg Gly Leu Leu Thr Leu Leu Leu Pro Pro 
1               5                   10                  15      


Pro Pro Leu Tyr Thr Arg His Arg Met Leu Gly Pro Glu Ser Val Pro 
            20                  25                  30          


Pro Pro Lys Arg Ser Arg Ser Lys Leu Met Ala Pro Pro Arg Ile 
        35                  40                  45          


<210>  653
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9HBH1 mitochondrial targeting peptide

<400>  653

Met Ala Arg Leu Trp Gly Ala Leu Ser Leu Trp Pro Leu Trp Ala Ala 
1               5                   10                  15      


Val Pro Trp Gly Gly Ala Ala Ala Val Gly Val Arg Ala Cys Ser Ser 
            20                  25                  30          


Thr Ala Ala Pro Asp Gly Val 
        35                  


<210>  654
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9HC36 mitochondrial targeting peptide

<400>  654

Met Ala Ala Leu Val Arg Pro Ala Arg Phe Val Val Arg Pro Leu Leu 
1               5                   10                  15      


Gln Val Val Gln Ala Trp Asp Leu Asp Ala Arg Arg Trp Val Arg Ala 
            20                  25                  30          


Leu Arg Arg Ser Pro Val Lys Val 
        35                  40  


<210>  655
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9HCC0 mitochondrial targeting peptide

<400>  655

Met Trp Ala Val Leu Arg Leu Ala Leu Arg Pro Cys Ala Arg Ala Ser 
1               5                   10                  15      


Pro Ala Gly Pro Arg Ala 
            20          


<210>  656
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9HD23 mitochondrial targeting peptide

<400>  656

Met Glu Cys Leu Arg Ser Leu Pro Cys Leu Leu Pro Arg Ala Met Arg 
1               5                   10                  15      


Leu Pro Arg Arg Thr Leu Cys Ala Leu Ala Leu Asp Val Thr Ser Val 
            20                  25                  30          


Gly Pro Pro Val Ala Ala Cys Gly Arg Arg Ala Asn Leu Ile Gly Arg 
        35                  40                  45              


Ser 
    


<210>  657
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9NNW7 mitochondrial targeting peptide

<400>  657

Met Ala Ala Met Ala Val Ala Leu Arg Gly Leu Gly Gly Arg Phe Arg 
1               5                   10                  15      


Trp Arg Thr Gln Ala Val Ala Gly Gly Val Arg Gly Ala Ala Arg Gly 
            20                  25                  30          


Ala Ala Ala Gly 
        35      


<210>  658
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9NP81 mitochondrial targeting peptide

<400>  658

Met Ala Ala Ser Met Ala Arg Arg Leu Trp Pro Leu Leu Thr Arg Arg 
1               5                   10                  15      


Gly Phe Arg Pro Arg Gly Gly Cys Ile Ser Asn Asp Ser Pro Arg Arg 
            20                  25                  30          


Ser Phe 
        


<210>  659
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9NPB1 mitochondrial targeting peptide

<400>  659

Met Ile Arg Leu Gly Gly Trp Cys Ala Arg Arg Leu Cys Ser Ala Ala 
1               5                   10                  15      


Val Pro Ala Gly Arg Arg Gly Ala Ala Gly Gly Leu Gly Leu Ala 
            20                  25                  30      


<210>  660
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9NPH0 mitochondrial targeting peptide

<400>  660

Met Ile Thr Gly Val Phe Ser Met Arg Leu Trp Thr Pro Val Gly Val 
1               5                   10                  15      


Leu Thr Ser Leu Ala Tyr Cys Leu His Gln Arg Arg Val Ala Leu Ala 
            20                  25                  30          


<210>  661
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9NQ50 mitochondrial targeting peptide

<400>  661

Met Thr Ala Ser Val Leu Arg Ser Ile Ser Leu Ala Leu Arg Pro Thr 
1               5                   10                  15      


Ser Gly Leu Leu Gly Thr Trp Gln Thr Gln Leu Arg Glu Thr His Gln 
            20                  25                  30          


Arg Ala Ser Leu Leu Ser Phe Trp Glu Leu Ile Pro Met Arg 
        35                  40                  45      


<210>  662
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9NQZ5 mitochondrial targeting peptide

<400>  662

Met Leu Pro Arg Arg Leu Leu Ala Ala Trp Leu Ala Gly Thr Arg Gly 
1               5                   10                  15      


Gly Gly Leu Leu Ala Leu Leu Ala Asn Gln Cys Arg Phe Val Thr Gly 
            20                  25                  30          


Leu Arg Val Arg Arg Ala Gln Gln Ile Ala Gln Leu Tyr Gly Arg Leu 
        35                  40                  45              


Tyr Ser Glu Ser Ser Arg Arg Val Leu Leu 
    50                  55              


<210>  663
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9NR28 mitochondrial targeting peptide

<400>  663

Met Ala Ala Leu Lys Ser Trp Leu Ser Arg Ser Val Thr Ser Phe Phe 
1               5                   10                  15      


Arg Tyr Arg Gln Cys Leu Cys Val Pro Val Val Ala Asn Phe Lys Lys 
            20                  25                  30          


Arg Cys Phe Ser Glu Leu Ile Arg Pro Trp His Lys Thr Val Thr Ile 
        35                  40                  45              


Gly Phe Gly Val Thr Leu Cys 
    50                  55  


<210>  664
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9NRK6 mitochondrial targeting peptide

<400>  664

Met Arg Gly Pro Pro Ala Trp Pro Leu Arg Leu Leu Glu Pro Pro Ser 
1               5                   10                  15      


Pro Ala Glu Pro Gly Arg Leu Leu Pro Val Ala Cys Val Trp Ala Ala 
            20                  25                  30          


Ala Ser Arg Val Pro Gly Ser Leu Ser Pro Phe Thr Gly Leu Arg Pro 
        35                  40                  45              


Ala Arg Leu Trp Gly Ala Gly Pro Ala Leu Leu Trp Gly Val Gly Ala 
    50                  55                  60                  


Ala Arg Arg Trp Arg Ser Gly Cys Arg Gly Gly Gly Pro Gly Ala Ser 
65                  70                  75                  80  


Arg Gly Val Leu Gly Leu Ala Arg Leu Leu Gly Leu Trp Ala Arg Gly 
                85                  90                  95      


Pro Gly Ser Cys Arg Cys Gly Ala Phe 
            100                 105 


<210>  665
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9NRP4 mitochondrial targeting peptide

<400>  665

Met Pro Gly Arg His Val Ser Arg Val Arg Ala Leu Tyr Lys Arg Val 
1               5                   10                  15      


Leu Gln Leu His Arg Val Leu Pro Pro Asp Leu Lys Ser Leu 
            20                  25                  30  


<210>  666
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9NRX2 mitochondrial targeting peptide

<400>  666

Met Arg Leu Ser Val Ala Ala Ala 
1               5               


<210>  667
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9NS18 mitochondrial targeting peptide

<400>  667

Met Ile Trp Arg Arg Ala Ala Leu Ala Gly Thr Arg Leu Val Trp Ser 
1               5                   10                  15      


Arg Ser Gly 
            


<210>  668
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9NSE4 mitochondrial targeting peptide

<400>  668

Met Arg Trp Gly Leu Arg Pro Arg Gly Pro Gly Ala Ala Ala Leu Ala 
1               5                   10                  15      


Thr Ala Arg Ser Leu Trp Gly Thr Pro Arg Leu Pro Cys Ser Pro Gly 
            20                  25                  30          


Trp Gln Gly Ala Thr Lys Arg Leu Leu Val Arg Ser Val Ser Gly Ala 
        35                  40                  45              


<210>  669
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9NUB1 mitochondrial targeting peptide

<400>  669

Met Ala Ala Arg Thr Leu Gly Arg Gly Val Gly Arg Leu Leu Gly Ser 
1               5                   10                  15      


Leu Arg Gly Leu Ser Gly Gln Pro Ala Arg Pro Pro Cys Gly Val Ser 
            20                  25                  30          


Ala Pro Arg Arg Ala 
        35          


<210>  670
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9NUJ1 mitochondrial targeting peptide

<400>  670

Met Ala Val Ala Arg Leu Ala Ala Val Ala Ala Trp Val Pro Cys Arg 
1               5                   10                  15      


Ser Trp Gly Trp Ala Ala Val Pro Phe Gly Pro His Arg Gly Leu Ser 
            20                  25                  30          


Val Leu Leu Ala Arg Ile Pro Gln Arg Ala Pro Arg Trp Leu Pro Ala 
        35                  40                  45              


Cys Arg Gln Lys 
    50          


<210>  671
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9NUT2 mitochondrial targeting peptide

<400>  671

Met Leu Val His Leu Phe Arg Val Gly Ile Arg Gly Gly Pro Phe Pro 
1               5                   10                  15      


Gly Arg Leu Leu Pro Pro Leu Arg Phe Gln Thr Phe Ser Ala Val Arg 
            20                  25                  30          


Asn Thr Trp Arg Asn Gly Lys Thr Gly Gln Leu His Lys Ala Glu Gly 
        35                  40                  45              


Glu Tyr Ser Asp Gly Tyr Arg 
    50                  55  


<210>  672
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9NVH6 mitochondrial targeting peptide

<400>  672

Met Trp Tyr His Arg Leu Ser His Leu His Ser Arg Leu Gln Asp 
1               5                   10                  15  


<210>  673
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9NVS2 mitochondrial targeting peptide

<400>  673

Met Ala Ala Leu Lys Ala Leu Val Ser Gly Cys Gly Arg Leu Leu Arg 
1               5                   10                  15      


Gly Leu Leu Ala Gly Pro Ala Ala Thr Ser Trp Ser Arg Leu Pro Ala 
            20                  25                  30          


Arg Gly 
        


<210>  674
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9NVV4 mitochondrial targeting peptide

<400>  674

Met Ala Val Pro Gly Val Gly Leu Leu Thr Arg Leu Asn Leu Cys Ala 
1               5                   10                  15      


Arg Arg Arg Thr Arg Val Gln Arg Pro Ile Val Arg Leu Leu Ser Cys 
            20                  25                  30          


Pro Gly Thr Val Ala 
        35          


<210>  675
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9NWR8 mitochondrial targeting peptide

<400>  675

Met Leu Gln Arg Gly Leu Trp Pro Trp Arg Thr Arg Leu Leu Pro Thr 
1               5                   10                  15      


Pro Gly Thr Trp Arg Pro Ala Arg Pro Trp Pro Leu Pro Pro Pro Pro 
            20                  25                  30          


Gln Val Leu 
        35  


<210>  676
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9NWS8 mitochondrial targeting peptide

<400>  676

Met Pro Ala Thr Leu Leu Arg Ala Val Ala Arg Ser 
1               5                   10          


<210>  677
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9NWU1 mitochondrial targeting peptide

<400>  677

Met Ser Asn Cys Leu Gln Asn Phe Leu Lys Ile Thr Ser Thr Arg Leu 
1               5                   10                  15      


Leu Cys Ser Arg Leu Cys Gln Gln Leu Arg Ser 
            20                  25          


<210>  678
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9NWU5 mitochondrial targeting peptide

<400>  678

Met Ala Ala Ala Val Leu Gly Gln Leu Gly Ala Leu Trp Ile His Asn 
1               5                   10                  15      


Leu Arg Ser Arg Gly Lys Leu Ala Leu Gly Val Leu Pro Gln Ser Tyr 
            20                  25                  30          


Ile His Thr Ser Ala Ser Leu Asp 
        35                  40  


<210>  679
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9NX14 mitochondrial targeting peptide

<400>  679

Met Ala Ala Gly Leu Phe Gly Leu Ser Ala Arg Arg Leu Leu Ala Ala 
1               5                   10                  15      


Ala Ala Thr Arg Gly Leu Pro Ala Ala Arg Val Arg Trp 
            20                  25                  


<210>  680
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9NX18 mitochondrial targeting peptide

<400>  680

Met Ala Val Ser Thr Val Phe Ser Thr Ser Ser Leu Met Leu Ala Leu 
1               5                   10                  15      


Ser Arg His Ser Leu Leu Ser Pro Leu Leu Ser Val Thr 
            20                  25                  


<210>  681
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9NX20 mitochondrial targeting peptide

<400>  681

Met Trp Arg Leu Leu Ala Arg Ala Ser Ala Pro Leu Leu Arg Val Pro 
1               5                   10                  15      


Leu Ser Asp Ser Trp Ala Leu Leu Pro Ala Ser Ala Gly Val Lys Thr 
            20                  25                  30          


Leu Leu Pro Val 
        35      


<210>  682
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9NX46 mitochondrial targeting peptide

<400>  682

Met Ala Ala Ala Ala Met Ala Ala Ala Ala Gly Gly Gly Ala Gly Ala 
1               5                   10                  15      


Ala Arg Ser Leu Ser Arg Phe Arg Gly Cys Leu 
            20                  25          


<210>  683
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9NXA8 mitochondrial targeting peptide

<400>  683

Met Arg Pro Leu Gln Ile Val Pro Ser Arg Leu Ile Ser Gln Leu Tyr 
1               5                   10                  15      


Cys Gly Leu Lys Pro Pro Ala Ser Thr Arg Asn Gln Ile Cys Leu Lys 
            20                  25                  30          


Met Ala Arg Pro 
        35      


<210>  684
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9NZJ6 mitochondrial targeting peptide

<400>  684

Met Trp Ser Gly Arg Lys Leu Gly Ser Ser Gly Gly Trp Phe Leu Arg 
1               5                   10                  15      


Val Leu Gly Pro Gly Gly Cys Asn Thr Lys Ala Ala Arg Pro Leu Ile 
            20                  25                  30          


Ser Ser Ala Val Tyr Val Lys Asn Gln Leu Ser Gly Thr Leu Gln Ile 
        35                  40                  45              


Lys Pro Gly Val Phe Asn Glu Tyr Arg Thr Ile Trp Phe Lys Ser Tyr 
    50                  55                  60                  


Arg Thr Ile Phe Ser Cys Leu Asn Arg Ile Lys Ser Phe Arg Tyr Pro 
65                  70                  75                  80  


Trp Ala Arg Leu Tyr 
                85  


<210>  685
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9P015 mitochondrial targeting peptide

<400>  685

Met Ala Gly Pro Leu Gln Gly Gly Gly Ala Arg Ala Leu Asp Leu Leu 
1               5                   10                  15      


Arg Gly Leu Pro Arg 
            20      


<210>  686
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9P0J1 mitochondrial targeting peptide

<400>  686

Met Pro Ala Pro Thr Gln Leu Phe Phe Pro Leu Ile Arg Asn Cys Glu 
1               5                   10                  15      


Leu Ser Arg Ile Tyr Gly Thr Ala Cys Tyr Cys His His Lys His Leu 
            20                  25                  30          


Cys Cys Ser Ser Ser Tyr Ile Pro Gln Ser Arg Leu Arg Tyr Thr Pro 
        35                  40                  45              


His Pro Ala Tyr Ala Thr Phe Cys Arg Pro Lys Glu Asn Trp Trp Gln 
    50                  55                  60                  


Tyr Thr Gln Gly Arg Arg Tyr 
65                  70      


<210>  687
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9P2J9 mitochondrial targeting peptide

<400>  687

Met Ser Ser Thr Val Ser Tyr Trp Ile Leu Asn Ser Thr Arg Asn Ser 
1               5                   10                  15      


Ile Ala Thr Leu Gln Gly Gly Arg Arg Leu Tyr Ser Arg Tyr Val Ser 
            20                  25                  30          


Asn Arg Asn Lys Leu Lys Trp Arg Leu Phe Ser Arg Val Pro Pro Thr 
        35                  40                  45              


Leu Asn Ser Ser Pro Cys Gly Gly Phe Thr Leu Cys Lys Ala Tyr Arg 
    50                  55                  60                  


His Thr 
65      


<210>  688
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9P2R7 mitochondrial targeting peptide

<400>  688

Met Ala Ala Ser Met Phe Tyr Gly Arg Leu Val Ala Val Ala Thr Leu 
1               5                   10                  15      


Arg Asn His Arg Pro Arg Thr Ala Gln Arg Ala Ala Ala Gln Val Leu 
            20                  25                  30          


Gly Ser Ser Gly Leu Phe Asn Asn His Gly Leu Gln Val Gln Gln Gln 
        35                  40                  45              


Gln Gln Arg Asn 
    50          


<210>  689
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9UDR5 mitochondrial targeting peptide

<400>  689

Met Leu Gln Val His Arg Thr Gly Leu Gly Arg Leu Gly Val Ser Leu 
1               5                   10                  15      


Ser Lys Gly Leu His His Lys Ala Val Leu Ala Val Arg Arg Glu Asp 
            20                  25                  30          


<210>  690
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9UGC7 mitochondrial targeting peptide

<400>  690

Met Arg Ser Arg Val Leu Trp Gly Ala Ala Arg Trp Leu Trp Pro Arg 
1               5                   10                  15      


Arg Ala Val Gly Pro Ala Arg Arg Pro Leu 
            20                  25      


<210>  691
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9UGM6 mitochondrial targeting peptide

<400>  691

Met Ala Leu His Ser Met Arg Lys Ala Arg Glu Arg Trp Ser Phe Ile 
1               5                   10                  15      


Arg Ala 
        


<210>  692
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9UI17 mitochondrial targeting peptide

<400>  692

Met Leu Arg Pro Gly Ala Gln Leu Leu Arg Gly Leu Leu Leu Arg Ser 
1               5                   10                  15      


Cys Pro Leu Gln Gly Ser Pro Gly Arg Pro Arg Ser Val Cys Gly Arg 
            20                  25                  30          


Glu Gly Glu Glu Lys Pro Pro Leu Ser Ala Glu Thr Gln Trp Lys Asp 
        35                  40                  45              


Arg Ala 
    50  


<210>  693
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9UI32 mitochondrial targeting peptide

<400>  693

Met Arg Ser Met Lys Ala Leu Gln Lys Ala Leu Ser Arg Ala 
1               5                   10                  


<210>  694
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9UI43 mitochondrial targeting peptide

<400>  694

Met Ala Gly Tyr Leu Lys Leu Val Cys Val Ser Phe Gln Arg Gln Gly 
1               5                   10                  15      


Phe His 
        


<210>  695
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9UII2 mitochondrial targeting peptide

<400>  695

Met Ala Val Thr Ala Leu Ala Ala Arg Thr Trp Leu Gly Val Trp Gly 
1               5                   10                  15      


Val Arg Thr Met Gln Ala Arg Gly Phe 
            20                  25  


<210>  696
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9UJ68 mitochondrial targeting peptide

<400>  696

Met Leu Ser Ala Thr Arg Arg Ala Cys Gln Leu Leu Leu Leu His Ser 
1               5                   10                  15      


Leu Phe Pro Val Pro Arg Met 
            20              


<210>  697
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9UJZ1 mitochondrial targeting peptide

<400>  697

Met Leu Ala Arg Ala Ala Arg Gly Thr Gly Ala Leu Leu Leu Arg Gly 
1               5                   10                  15      


Ser Leu Leu Ala Ser Gly Arg Ala Pro Arg Arg Ala 
            20                  25              


<210>  698
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9UKU7 mitochondrial targeting peptide

<400>  698

Met Leu Trp Ser Gly Cys Arg Arg Phe Gly Ala Arg Leu Gly Cys Leu 
1               5                   10                  15      


Pro Gly Gly Leu Arg Val 
            20          


<210>  699
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9UL12 mitochondrial targeting peptide

<400>  699

Met Ala Ser Leu Ser Arg Ala Leu Arg Val Ala Ala Ala His Pro Arg 
1               5                   10                  15      


Gln Ser Pro Thr Arg Gly 
            20          


<210>  700
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9ULD0 mitochondrial targeting peptide

<400>  700

Met Ser Gln Leu Arg Leu Leu Pro Ser Arg Leu Gly Val Gln Ala Ala 
1               5                   10                  15      


Arg Leu Leu Ala Ala His Asp Val Pro Val Phe Gly Trp Arg Ser Arg 
            20                  25                  30          


Ser Ser Gly Pro Pro Ala Thr Phe Pro Ser Ser Lys Gly Gly Gly Gly 
        35                  40                  45              


Ser Ser Tyr Met Glu Glu Met Tyr Phe Ala Trp Leu Glu Asn Pro Gln 
    50                  55                  60                  


Ser Val His Lys Ser Trp Asp Ser Phe 
65                  70              


<210>  701
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9UMS0 mitochondrial targeting peptide

<400>  701

Met Ala Ala Thr Ala Arg Arg Gly Trp 
1               5                   


<210>  702
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9Y234 mitochondrial targeting peptide

<400>  702

Met Leu Ile Pro Phe Ser Met Lys Asn Cys Phe Gln Leu Leu Cys Asn 
1               5                   10                  15      


Cys Gln Val Pro Ala Ala Gly Phe Lys 
            20                  25  


<210>  703
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9Y2C4 mitochondrial targeting peptide

<400>  703

Met Ala Ile Lys Ser Ile Ala Ser Arg Leu Arg Gly Ser Arg Arg Phe 
1               5                   10                  15      


Leu Ser Gly Phe Val Ala Gly Ala Val Val Gly Ala Ala Gly Ala Gly 
            20                  25                  30          


Leu Ala Ala Leu Gln Phe Phe Arg Ser 
        35                  40      


<210>  704
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9Y2D0 mitochondrial targeting peptide

<400>  704

Met Val Val Met Asn Ser Leu Arg Val Ile Leu Gln Ala Ser Pro Gly 
1               5                   10                  15      


Lys Leu Leu Trp Arg Lys Phe Gln Ile Pro Arg Phe Met Pro Ala Arg 
            20                  25                  30          


Pro 
    


<210>  705
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9Y2Q9 mitochondrial targeting peptide

<400>  705

Met Ala Ala Leu Cys Arg Thr Arg Ala Val Ala Ala Glu Ser His Phe 
1               5                   10                  15      


Leu Arg Val Phe Leu Phe Phe Arg Pro Phe Arg Gly Val Gly Thr Glu 
            20                  25                  30          


Ser Gly Ser Glu Ser Gly Ser Ser Asn Ala Lys Glu Pro Lys Thr Arg 
        35                  40                  45              


Ala Gly Gly Phe Ala Ser Ala Leu Glu Arg His Ser Glu Leu Leu Gln 
    50                  55                  60                  


Lys Val Glu Pro Leu Gln Lys 
65                  70      


<210>  706
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9Y2R5 mitochondrial targeting peptide

<400>  706

Met Ser Val Val Arg Ser Ser Val His Ala Arg Trp Ile Val Gly Lys 
1               5                   10                  15      


Val Ile Gly Thr 
            20  


<210>  707
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9Y2R9 mitochondrial targeting peptide

<400>  707

Met Ala Ala Pro Ala Val Lys Val Ala Arg Gly Trp Ser Gly Leu Ala 
1               5                   10                  15      


Leu Gly Val Arg Arg Ala Val Leu Gln Leu Pro Gly Leu Thr Gln Val 
            20                  25                  30          


Arg Trp Ser Arg Tyr 
        35          


<210>  708
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9Y2Z2 mitochondrial targeting peptide

<400>  708

Met Phe Tyr Phe Arg Gly Cys Gly Arg Trp Val Ala Val Ser Phe Thr 
1               5                   10                  15      


Lys Gln Gln Phe Pro Leu Ala Arg Leu 
            20                  25  


<210>  709
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9Y2Z4 mitochondrial targeting peptide

<400>  709

Met Ala Ala Pro Ile Leu Arg Ser Phe Ser Trp Gly Arg Trp Ser Gly 
1               5                   10                  15      


<210>  710
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9Y2Z9 mitochondrial targeting peptide

<400>  710

Met Ala Ala Arg Leu Val Ser Arg Cys Gly Ala Val Arg Ala Ala Pro 
1               5                   10                  15      


His Ser Gly Pro Leu Val Ser Trp Arg Arg Trp Ser 
            20                  25              


<210>  711
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9Y305 mitochondrial targeting peptide

<400>  711

Met Arg Arg Ala Ala Leu Arg Leu Cys Ala Leu Gly Lys Gly Gln Leu 
1               5                   10                  15      


Thr Pro Gly Arg Gly 
            20      


<210>  712
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9Y375 mitochondrial targeting peptide

<400>  712

Met Ala Leu Val His Lys Leu Leu Arg Gly Thr Tyr Phe Leu Arg Lys 
1               5                   10                  15      


Phe Ser Lys Pro Thr Ser Ala Leu 
            20                  


<210>  713
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9Y3A0 mitochondrial targeting peptide

<400>  713

Met Ala Thr Leu Leu Arg Pro Val Leu Arg Arg Leu Cys Gly Leu Pro 
1               5                   10                  15      


Gly Leu Gln Arg Pro Ala Ala Glu Met Pro Leu Arg Ala Arg 
            20                  25                  30  


<210>  714
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9Y3B8 mitochondrial targeting peptide

<400>  714

Met Leu Gly Gly Ser Leu Gly Ser Arg Leu Leu Arg Gly Val Gly Gly 
1               5                   10                  15      


Ser His Gly Arg Phe Gly Ala Arg Gly 
            20                  25  


<210>  715
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9Y3D2 mitochondrial targeting peptide

<400>  715

Met Ala Arg Leu Leu Trp Leu Leu Arg Gly Leu Thr Leu Gly Thr Ala 
1               5                   10                  15      


Pro Arg Arg Ala 
            20  


<210>  716
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9Y3D3 mitochondrial targeting peptide

<400>  716

Met Val His Leu Thr Thr Leu Leu Cys Lys Ala Tyr Arg Gly Gly His 
1               5                   10                  15      


Leu Thr Ile Arg Leu Ala Leu Gly Gly Cys Thr Asn Arg Pro Phe Tyr 
            20                  25                  30          


Arg Ile 
        


<210>  717
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9Y3E5 mitochondrial targeting peptide

<400>  717

Met Pro Ser Lys Ser Leu Val Met Glu Tyr Leu Ala His Pro Ser Thr 
1               5                   10                  15      


Leu Gly Leu Ala Val Gly Val Ala Cys Gly Met Cys Leu Gly Trp Ser 
            20                  25                  30          


Leu Arg Val Cys Phe Gly Met Leu Pro Lys Ser Lys Thr Ser Lys Thr 
        35                  40                  45              


His Thr Asp Thr Glu Ser Glu Ala Ser Ile Leu Gly Asp Ser 
    50                  55                  60          


<210>  718
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9Y6E7 mitochondrial targeting peptide

<400>  718

Met Lys Met Ser Phe Ala Leu Thr Phe Arg Ser Ala Lys Gly Arg Trp 
1               5                   10                  15      


Ile Ala Asn Pro Ser Gln Pro Cys Ser Lys Ala Ser 
            20                  25              


<210>  719
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q9Y6G3 mitochondrial targeting peptide

<400>  719

Met Ala Val Ala Ala Val Lys Trp Val Met Ser Lys Arg Thr Ile Leu 
1               5                   10                  15      


Lys His Leu Phe Pro Val Gln Asn Gly Ala Leu Tyr Cys Val Cys His 
            20                  25                  30          


<210>  720
<211>  87
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-142

<400>  720
gacagugcag ucacccauaa aguagaaagc acuacuaaca gcacuggagg guguaguguu       60

uccuacuuua uggaugagug uacugug                                           87


<210>  721
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-142-3p

<400>  721
uguaguguuu ccuacuuuau gga                                               23


<210>  722
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-142-3p binding site

<400>  722
uccauaaagu aggaaacacu aca                                               23


<210>  723
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-142-5p

<400>  723
cauaaaguag aaagcacuac u                                                 21


<210>  724
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-142-5p binding site

<400>  724
aguagugcuu ucuacuuuau g                                                 21


<210>  725
<211>  142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Upstream UTR including miR142-3p

<400>  725
tgataatagt ccataaagta ggaaacacta cagctggagc ctcggtggcc atgcttcttg       60

ccccttgggc ctccccccag cccctcctcc ccttcctgca cccgtacccc cgtggtcttt      120

gaataaagtc tgagtgggcg gc                                               142


<210>  726
<211>  142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Upstream UTR including miR142-3p

<400>  726
tgataatagg ctggagcctc ggtggctcca taaagtagga aacactacac atgcttcttg       60

ccccttgggc ctccccccag cccctcctcc ccttcctgca cccgtacccc cgtggtcttt      120

gaataaagtc tgagtgggcg gc                                               142


<210>  727
<211>  142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Upstream UTR including miR142-3p

<400>  727
tgataatagg ctggagcctc ggtggccatg cttcttgccc cttccataaa gtaggaaaca       60

ctacatgggc ctccccccag cccctcctcc ccttcctgca cccgtacccc cgtggtcttt      120

gaataaagtc tgagtgggcg gc                                               142


<210>  728
<211>  142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Upstream UTR including miR142-3p

<400>  728
tgataatagg ctggagcctc ggtggccatg cttcttgccc cttgggcctc cccccagtcc       60

ataaagtagg aaacactaca cccctcctcc ccttcctgca cccgtacccc cgtggtcttt      120

gaataaagtc tgagtgggcg gc                                               142


<210>  729
<211>  142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Upstream UTR including miR142-3p

<400>  729
tgataatagg ctggagcctc ggtggccatg cttcttgccc cttgggcctc cccccagccc       60

ctcctcccct tctccataaa gtaggaaaca ctacactgca cccgtacccc cgtggtcttt      120

gaataaagtc tgagtgggcg gc                                               142


<210>  730
<211>  142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Upstream UTR including miR142-3p

<400>  730
tgataatagg ctggagcctc ggtggccatg cttcttgccc cttgggcctc cccccagccc       60

ctcctcccct tcctgcaccc gtaccccctc cataaagtag gaaacactac agtggtcttt      120

gaataaagtc tgagtgggcg gc                                               142


<210>  731
<211>  142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Upstream UTR including miR142-3p

<400>  731
tgataatagg ctggagcctc ggtggccatg cttcttgccc cttgggcctc cccccagccc       60

ctcctcccct tcctgcaccc gtacccccgt ggtctttgaa taaagttcca taaagtagga      120

aacactacac tgagtgggcg gc                                               142


<210>  732
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  732
atgctgcggg ccaagaacca gctgttcctg ctgagccctc actacctgcg gcaggtgaag       60

gagagcagcg gcagccggct gatccagcag cggctgctgc accagcagca gcccctgcac      120

cccgagtggg ccgccctggc caagaagcag ctgaagggca agaaccccga ggacctgatc      180

tggcacacgc ccgagggcat cagcatcaag cccctgtaca gcaagcggga caccatggac      240

ctgcccgagg agctgcccgg cgtgaagccc ttcacccggg gcccctaccc caccatgtac      300

accttccggc cctggaccat ccggcagtac gccggcttca gcaccgtgga ggagagcaac      360

aagttctaca aggacaacat caaggccggc cagcagggcc tgagcgtggc cttcgacctg      420

gccacccacc ggggctacga cagcgacaac ccacgggtgc ggggcgacgt gggcatggcc      480

ggcgtggcca tcgacaccgt ggaggacacc aagatcctgt tcgacggcat ccctctggag      540

aagatgagcg tgagcatgac catgaacggc gccgtgatcc ccgtgctggc caacttcatc      600

gtgaccggcg aggagcaggg cgtgcccaag gagaagctga ccggcaccat ccagaacgac      660

atcctgaagg agttcatggt gcggaacacc tacatcttcc ctcccgagcc cagcatgaag      720

atcatcgccg acatcttcga gtacaccgcc aagcacatgc ccaagttcaa cagcatcagc      780

atcagcggct accacatgca ggaggccggc gccgacgcca tcctggagct ggcctacacc      840

ctggccgacg gcctggagta cagccggacc ggcctgcagg ccggcctgac catcgacgag      900

ttcgcgcccc ggctgagctt cttctggggc atcggcatga acttctacat ggagatcgcc      960

aagatgcggg ccggccggcg gctgtgggcc cacctgatcg agaagatgtt ccagcccaag     1020

aacagcaaga gcctgctgct gcgggcccac tgccagacca gcggctggag cctgaccgag     1080

caggacccct acaacaacat cgtgcggacc gccatcgagg ccatggccgc cgtgttcggc     1140

ggcacccaga gcctgcacac caacagcttc gacgaggccc tgggcctgcc caccgtgaag     1200

agcgcccgga tcgcccggaa cacccagatc atcatccagg aggagagcgg catccccaag     1260

gtggccgacc cctggggcgg cagctacatg atggagtgcc tgaccaacga cgtgtacgac     1320

gccgccctga agctgatcaa cgagatcgag gagatgggcg gcatggccaa ggccgtggcc     1380

gagggcatcc ccaagctgcg gatcgaggag tgcgccgccc ggcggcaggc ccggatcgac     1440

agcggcagcg aggtgatcgt gggcgtgaac aagtaccagc tggagaagga ggacgccgtg     1500

gaggtgctgg ccatcgacaa caccagcgtg cggaaccggc agatcgagaa gctgaagaag     1560

atcaagagca gccgggacca ggccctggcc gagcggtgcc tggccgccct gaccgagtgc     1620

gccgccagcg gcgacggcaa catcctggcc ctggccgtgg acgccagccg ggcccggtgc     1680

accgtgggcg agatcaccga cgccctgaag aaggtgttcg gcgagcacaa ggccaacgac     1740

cggatggtga gcggcgccta ccggcaggag ttcggcgaga gcaaggagat caccagcgcc     1800

atcaagcggg tgcacaagtt catggagcgg gagggccggc ggccccggct gctggtggcc     1860

aagatgggcc aggacggcca cgaccggggc gccaaggtga tcgccaccgg cttcgccgac     1920

ctgggcttcg acgtggacat cggcccactg ttccagacgc cccgggaggt ggcccagcag     1980

gccgtggacg ccgacgtgca cgccgtgggc gtgagcaccc tggccgccgg ccacaagacc     2040

ctggtgcccg agctgatcaa ggagctgaac agcctgggcc ggcccgacat cctggtgatg     2100

tgcggcggcg tgatcccgcc ccaggactac gagttcctgt tcgaggtggg cgtgagcaac     2160

gtgttcggcc ccggcacccg gatccccaag gccgccgtgc aggtgctgga cgacatcgag     2220

aagtgcctgg agaagaagca gcagagcgtg                                      2250


<210>  733
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  733
atgctgcggg ccaagaacca gctgttcctg ctgagcccgc actacctgcg gcaggtgaag       60

gagagcagcg gcagccggct gatccagcag cgcctcctcc accagcagca gcccctccac      120

cccgagtggg ccgccctcgc caagaagcag ctcaagggca agaaccccga ggacctcatc      180

tggcacacgc ccgagggcat ctccatcaag cccctctact ccaagcgcga caccatggac      240

ctccccgagg agctccccgg cgtcaagccc ttcacccgcg gcccctaccc caccatgtac      300

accttccgcc cctggaccat ccgccagtac gccggcttct ccaccgtcga ggagtccaac      360

aagttctaca aggacaacat caaggccggc cagcagggcc tctccgtcgc cttcgacctc      420

gccacccacc gcggctacga ctccgacaac ccgcgcgtcc gcggcgacgt cggcatggcc      480

ggcgtcgcca tcgacaccgt cgaggacacc aagatcctct tcgacggcat ccctctcgag      540

aagatgtccg tctccatgac catgaacggc gccgtcatcc ccgtcctcgc caacttcatc      600

gtcaccggcg aggagcaggg cgtccccaag gagaagctca ccggcaccat ccagaacgac      660

atcctcaagg agttcatggt ccgcaacacc tacatcttcc ctcccgagcc ctccatgaag      720

atcatcgccg acatcttcga gtacaccgcc aagcacatgc ccaagttcaa ctccatctcc      780

atctccggct accacatgca ggaggccggc gccgacgcca tcctcgagct cgcctacacc      840

ctcgccgacg gcctcgagta ctcccgcacc ggcctccagg ccggcctcac catcgacgag      900

ttcgcgcccc gcctctcctt cttctggggc atcggcatga acttctacat ggagatcgcc      960

aagatgcgcg ccggccgccg cctctgggcc cacctcatcg agaagatgtt ccagcccaag     1020

aactccaagt ccctcctcct ccgcgcccac tgccagacct ccggctggtc cctcaccgag     1080

caggacccct acaacaacat cgtccgcacc gccatcgagg ccatggccgc cgtcttcggc     1140

ggcacccagt ccctccacac caactccttc gacgaggccc tcggcctccc caccgtcaag     1200

tccgcccgca tcgcccgcaa cacccagatc atcatccagg aggagtccgg catccccaag     1260

gtcgccgacc cctggggcgg ctcctacatg atggagtgcc tcaccaacga cgtctacgac     1320

gccgccctca agctcatcaa cgagatcgag gagatgggcg gcatggccaa ggccgtcgcc     1380

gagggcatcc ccaagctccg catcgaggag tgcgccgccc gccgccaggc ccgcatcgac     1440

tccggctccg aggtcatcgt cggcgtcaac aagtaccagc tcgagaagga ggacgccgtc     1500

gaggtcctcg ccatcgacaa cacctccgtc cgcaaccgcc agatcgagaa gctcaagaag     1560

atcaagtcct cccgcgacca ggccctcgcc gagcgctgcc tcgccgccct caccgagtgc     1620

gccgcctccg gcgacggcaa catcctcgcc ctcgccgtcg acgcctcccg cgcccgctgc     1680

accgtcggcg agatcaccga cgccctcaag aaggtcttcg gcgagcacaa ggccaacgac     1740

cgcatggtct ccggcgccta ccgccaggag ttcggcgagt ccaaggagat cacctccgcc     1800

atcaagcgcg tccacaagtt catggagcgc gagggccgcc gcccgcgcct cctcgtcgcc     1860

aagatgggcc aggacggcca cgaccgcggc gccaaggtca tcgccaccgg cttcgccgac     1920

ctcggcttcg acgtcgacat cggcccactc ttccagacgc cccgcgaggt cgcccagcag     1980

gccgtcgacg ccgacgtcca cgccgtcggc gtctccaccc tcgccgccgg ccacaagacc     2040

ctcgtccccg agctcatcaa ggagctcaac tccctcggcc gccccgacat cctcgtcatg     2100

tgcggcggcg tcatccctcc ccaggactac gagttcctct tcgaggtcgg cgtctccaac     2160

gtcttcggcc ccggcacccg catccccaag gccgccgtcc aggtcctcga cgacatcgag     2220

aagtgcctcg agaagaagca gcagtccgtc                                      2250


<210>  734
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  734
atgctgcggg ccaagaacca gctgttcctg ctgagccccc actacctgcg gcaggtgaag       60

gagagcagcg gcagccggct gatccagcag cggctgctgc accagcagca gcccctgcac      120

cccgagtggg ccgccctggc caagaagcag ctgaagggca agaaccccga ggacctgatc      180

tggcacaccc ccgagggcat cagcatcaag cccctgtaca gcaagcggga caccatggac      240

ctgcccgagg agctgcccgg cgtgaagccc ttcacccggg gcccctaccc caccatgtac      300

accttccggc cctggaccat ccggcagtac gccggcttca gcaccgtgga ggagagcaac      360

aagttctaca aggacaacat caaggccggc cagcagggcc tgagcgtggc cttcgacctg      420

gccacccacc ggggctacga cagcgacaac ccccgggtgc ggggcgacgt gggcatggcc      480

ggcgtggcca tcgacaccgt ggaggacacc aagatcctgt tcgacggcat ccccctggag      540

aagatgagcg tgagcatgac catgaacggc gccgtgatcc ccgtgctggc caacttcatc      600

gtgaccggcg aggagcaggg cgtgcccaag gagaagctga ccggcaccat ccagaacgac      660

atcctgaagg agttcatggt gcggaacacc tacatcttcc cccccgagcc cagcatgaag      720

atcatcgccg acatcttcga gtacaccgcc aagcacatgc ccaagttcaa cagcatcagc      780

atcagcggct accacatgca ggaggccggc gccgacgcca tcctggagct ggcctacacc      840

ctggccgacg gcctggagta cagccggacc ggcctgcagg ccggcctgac catcgacgag      900

ttcgcccccc ggctgagctt cttctggggc atcggcatga acttctacat ggagatcgcc      960

aagatgcggg ccggccggcg gctgtgggcc cacctgatcg agaagatgtt ccagcccaag     1020

aacagcaaga gcctgctgct gcgggcccac tgccagacca gcggctggag cctgaccgag     1080

caggacccct acaacaacat cgtgcggacc gccatcgagg ccatggccgc cgtgttcggc     1140

ggcacccaga gcctgcacac caacagcttc gacgaggccc tgggcctgcc caccgtgaag     1200

agcgcccgga tcgcccggaa cacccagatc atcatccagg aggagagcgg catccccaag     1260

gtggccgacc cctggggcgg cagctacatg atggagtgcc tgaccaacga cgtgtacgac     1320

gccgccctga agctgatcaa cgagatcgag gagatgggcg gcatggccaa ggccgtggcc     1380

gagggcatcc ccaagctgcg gatcgaggag tgcgccgccc ggcggcaggc ccggatcgac     1440

agcggcagcg aggtgatcgt gggcgtgaac aagtaccagc tggagaagga ggacgccgtg     1500

gaggtgctgg ccatcgacaa caccagcgtg cggaaccggc agatcgagaa gctgaagaag     1560

atcaagagca gccgggacca ggccctggcc gagcggtgcc tggccgccct gaccgagtgc     1620

gccgccagcg gcgacggcaa catcctggcc ctggccgtgg acgccagccg ggcccggtgc     1680

accgtgggcg agatcaccga cgccctgaag aaggtgttcg gcgagcacaa ggccaacgac     1740

cggatggtga gcggcgccta ccggcaggag ttcggcgaga gcaaggagat caccagcgcc     1800

atcaagcggg tgcacaagtt catggagcgg gagggccggc ggccccggct gctggtggcc     1860

aagatgggcc aggacggcca cgaccggggc gccaaggtga tcgccaccgg cttcgccgac     1920

ctgggcttcg acgtggacat cggccccctg ttccagaccc cccgggaggt ggcccagcag     1980

gccgtggacg ccgacgtgca cgccgtgggc gtgagcaccc tggccgccgg ccacaagacc     2040

ctggtgcccg agctgatcaa ggagctgaac agcctgggcc ggcccgacat cctggtgatg     2100

tgcggcggcg tgatcccccc ccaggactac gagttcctgt tcgaggtggg cgtgagcaac     2160

gtgttcggcc ccggcacccg gatccccaag gccgccgtgc aggtgctgga cgacatcgag     2220

aagtgcctgg agaagaagca gcagagcgtg                                      2250


<210>  735
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  735
atgctgaggg ccaagaacca gctgttcctg ctcagccccc actacctgcg ccaggtgaag       60

gagtcctccg gctcccggct gatccagcag aggctcctgc accagcagca acccctgcat      120

ccggagtggg ccgccctcgc caagaaacag ttgaaaggca agaaccccga ggatctcatc      180

tggcataccc ccgagggcat cagcatcaag ccgctgtaca gcaagaggga caccatggat      240

ctcccggaag agctgcctgg cgtgaagccc ttcacccggg gtccctaccc cacgatgtac      300

accttccgcc cctggaccat caggcagtac gcgggcttta gcacggtcga ggagagcaac      360

aaattctaca aggacaacat caaggcgggc cagcagggcc tgagcgtggc cttcgaccta      420

gccacccacc ggggctatga cagcgacaac ccacgggtca ggggcgacgt gggcatggcg      480

ggcgtggcca tagacaccgt ggaggacacc aagatcctgt tcgacgggat cccacttgag      540

aagatgagcg tgtccatgac catgaacggc gccgtcatcc ccgtgctggc caacttcatc      600

gtgaccggcg aggagcaggg cgtgcccaag gagaagctga ccggcaccat acagaacgac      660

atcctgaagg agtttatggt gcgcaacacc tatatcttcc cccccgaacc cagcatgaag      720

atcatcgccg acatcttcga gtacaccgcg aagcacatgc ccaagttcaa ctccatcagc      780

atcagcggct accatatgca ggaggccggt gcggacgcca tcctggagct tgcctacacc      840

ctggccgacg ggctggagta cagcaggacc gggctccagg ccggtctgac catcgacgaa      900

ttcgccccca ggctgagctt cttctggggc atcggcatga acttctacat ggagatcgcc      960

aaaatgaggg ccggcaggag gctctgggcc cacctgatcg aaaaaatgtt ccagcccaaa     1020

aacagcaaat ccctgctgct gcgggcccac tgccagacca gcggctggag cctcaccgag     1080

caagacccct ataataacat cgtcaggacg gccatcgaag cgatggccgc cgtgttcgga     1140

ggcacccaga gcctccatac caacagcttc gacgaggccc tggggctgcc gacggtgaaa     1200

agcgccagga tcgccaggaa cacgcagatc atcatccagg aggagagcgg tatccccaag     1260

gtggccgacc cgtggggtgg cagctacatg atggagtgcc tcacgaacga cgtgtatgac     1320

gccgcgctga aactgatcaa cgagatcgag gagatggggg ggatggccaa ggccgtggct     1380

gagggtattc ccaagctgcg catagaggag tgcgccgcca ggcgccaggc caggatcgac     1440

tccgggtccg aggtaatcgt cggcgtgaac aagtaccagc tggagaagga ggacgccgtg     1500

gaggtgctgg caatcgacaa caccagcgtg aggaaccggc agatcgaaaa gctgaagaag     1560

attaaaagca gccgggacca agccctggca gagaggtgcc tggccgccct gacggaatgc     1620

gccgcctccg gggacggcaa catcctggct ctggccgtgg acgctagccg cgccaggtgc     1680

accgtcggcg agatcaccga cgccctgaag aaggtgttcg gggagcacaa ggcgaacgac     1740

cgcatggtgt ccggcgccta tcggcaagag ttcggggaga gcaaggaaat aaccagcgcc     1800

atcaaacgtg tgcacaagtt catggaaagg gagggcaggc gcccgaggct cctcgtcgcc     1860

aagatgggcc aggatgggca cgacagggga gccaaagtca tcgccaccgg gtttgcggac     1920

ctggggttcg acgtggacat cggccccctg ttccagacgc cgagggaggt ggcccaacag     1980

gccgtggacg ccgacgtgca cgccgtgggc gtgagcacgc tcgccgcggg gcacaagacc     2040

ctggtgcccg agctgattaa ggagctgaac agcctgggcc gacccgacat cctggtgatg     2100

tgcgggggcg tgatcccccc gcaggactac gaattcctgt tcgaggtggg agtcagcaac     2160

gtgttcgggc ccggtacgag gatcccgaag gccgccgtgc aggtgctgga cgacatcgag     2220

aaatgcctgg agaagaaaca gcagtccgtg                                      2250


<210>  736
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  736
atgctgcggg ccaaaaacca gctgttcctg ctctcccccc actacctgcg gcaggtgaag       60

gagagctccg gaagcaggct catacagcag cgcctgctcc accagcagca gcccctgcac      120

cccgagtggg ccgctctggc taagaaacag ctgaagggca aaaatcccga ggacctgatc      180

tggcataccc ccgagggcat cagcatcaaa cccctgtata gcaaacggga caccatggac      240

ctcccggagg agctgcccgg agttaagccc ttcaccaggg gcccctatcc aacaatgtac      300

accttccggc cctggaccat ccgacagtac gccggcttca gcacggtcga ggagtccaac      360

aagttctata aggacaacat caaggccggg cagcagggcc tgagcgtcgc cttcgacctg      420

gccacccacc gtgggtacga cagcgacaac cccagggtgc ggggcgacgt gggcatggcc      480

ggcgtggcca tagataccgt ggaggacacc aagatcctgt ttgacggcat ccccctggag      540

aagatgagcg tgtccatgac aatgaacggc gccgtgatcc ccgtgctcgc caatttcata      600

gtgaccggcg aggagcaggg cgtgccgaag gagaagttga ccggaacaat ccagaacgac      660

atcctgaagg agttcatggt gcggaacacc tacatcttcc cccccgagcc gtcaatgaag      720

atcatcgccg acatcttcga gtacaccgcc aagcacatgc ccaagttcaa cagcatcagc      780

atcagcggct atcatatgca ggaggccggg gccgacgcca tcctggagct ggcttacacg      840

ctggccgacg gcctggagta ttccaggacc ggcttacaag ccggcctgac catcgacgag      900

ttcgccccca ggctgagctt cttctggggc atcggcatga acttttacat ggagatcgcc      960

aagatgcgag ccggcaggcg gctgtgggcc cacctgattg agaaaatgtt ccagcccaag     1020

aactctaagt ccctgctgct gcgagcccac tgccagacca gcggctggag cctgaccgag     1080

caggacccct acaacaatat cgtgcgcacc gccatcgaag cgatggccgc cgtgtttggc     1140

ggcactcaga gcctgcacac caactccttt gacgaggccc tgggcctgcc caccgtgaag     1200

agtgccagga tagcgaggaa cacccaaatc ataatacagg aggagtccgg gatccccaag     1260

gtggccgacc cctggggcgg ctcctacatg atggagtgcc tgaccaacga tgtctacgac     1320

gccgccctga aactgatcaa cgagatcgag gagatgggag gcatggccaa ggccgtggct     1380

gagggcatcc ccaagctgag gatcgaggag tgcgcagccc gtcgtcaggc ccgcatcgac     1440

agcggctccg aggtgatcgt cggcgtgaac aagtaccagc tcgaaaaaga ggatgccgtg     1500

gaagtgctgg ccatcgacaa cacgtccgtc cgcaataggc agatcgagaa actgaagaag     1560

atcaagtcgt ccagggacca ggccctggcc gagagatgcc tggccgccct gacggaatgc     1620

gccgccagcg gggatggcaa tatcctggcc ctggccgtgg acgcctcccg ggccaggtgc     1680

acagtggggg agatcaccga cgcgctcaag aaggtgtttg gcgagcacaa ggccaacgat     1740

aggatggtga gcggcgcgta caggcaggag ttcggcgagt ccaaggagat caccagcgcc     1800

atcaagagag tgcacaagtt catggagcgg gaggggcgga ggccgaggct gctcgtggcg     1860

aagatgggcc aagacgggca cgacaggggc gccaaggtta tcgccaccgg gtttgcagac     1920

ctgggcttcg acgtggacat cggccccctc tttcagaccc cccgagaagt ggcacaacag     1980

gccgtggacg ccgacgtgca cgccgtgggc gtaagcaccc tggccgccgg ccataaaacc     2040

ctggtgccgg agctgatcaa ggagctcaac agcctgggcc gacccgacat cctggtgatg     2100

tgtgggggtg tgattcctcc ccaggattac gagttcctgt tcgaggtggg cgtgagcaat     2160

gtcttcggcc cggggaccag gatacccaag gcggccgtcc aggtgctcga cgacattgag     2220

aagtgcctcg agaagaaaca gcagtccgtg                                      2250


<210>  737
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  737
atgctcagag ccaaaaacca gctgttcctg ctcagccccc actatctgag gcaggtgaag       60

gagagctcag ggtccaggct gatccaacag cgcctgctcc accaacagca gccgctccat      120

cccgagtggg ccgccctggc caagaaacag ctgaagggga agaatcctga ggacctgatc      180

tggcacaccc ccgagggaat cagcatcaag cccctgtact ccaagaggga caccatggac      240

ctgcccgagg agctgccggg cgtgaagccc tttaccaggg gaccctaccc gacgatgtac      300

acctttcggc cctggaccat caggcagtac gccggcttct ccaccgtgga ggagagcaac      360

aagttctaca aggacaacat caaagcgggc caacagggtc tgagcgtggc cttcgatctg      420

gccacgcaca ggggctacga cagcgacaac cccagggtcc ggggcgacgt gggcatggcc      480

ggcgtggcca tcgacacggt ggaggacacc aagatcctgt tcgacggcat ccccctggag      540

aaaatgtccg ttagcatgac catgaatggg gccgtcatcc cggtgctggc caacttcatc      600

gtgaccgggg aggagcaggg agttcccaag gagaaactca ccgggaccat acagaacgac      660

atcctgaagg aatttatggt caggaacacc tatatatttc cccccgagcc cagcatgaag      720

atcatcgccg acatatttga gtacaccgcc aagcacatgc ccaagttcaa cagcatcagt      780

atcagcgggt atcacatgca ggaggccggc gccgacgcca tcctggagct ggcgtacacc      840

ctcgccgacg gcctggagta cagccggacc gggctccagg ccggcctcac catcgatgag      900

ttcgcccccc gcctgtcgtt tttctggggc atcgggatga atttctacat ggagatcgcg      960

aagatgcgcg ccggcaggag gctgtgggcg cacctcatcg agaaaatgtt ccagcccaag     1020

aactccaaga gcctgctgct gcgggcacac tgccagacct cgggttggtc cctgaccgag     1080

caggacccct acaacaatat cgtgaggacc gccatcgaag ccatggccgc cgtcttcggc     1140

ggcacccaga gcctgcacac caacagcttc gacgaggccc tgggccttcc caccgtgaag     1200

tccgcaagga tcgcccggaa cacccaaatc atcatccagg aggaaagcgg catccccaag     1260

gtggccgacc cctggggggg ctcctacatg atggagtgcc tgaccaacga cgtgtacgac     1320

gccgccctca agctgatcaa cgagatcgag gagatgggcg gcatggccaa ggccgtggcc     1380

gagggcatcc ccaagctgcg gatcgaggag tgcgccgcca ggaggcaggc ccggatagac     1440

tccggcagcg aagtgatcgt gggcgtcaat aaataccagc tggagaaaga ggacgccgtg     1500

gaggtgctcg ccatcgacaa cacgagcgtg cggaacaggc agatcgagaa actcaagaag     1560

atcaaaagct cgagggacca agccctggcc gagaggtgcc tggccgccct gaccgagtgc     1620

gccgccagtg gggacggcaa catcctggcc ctggccgtcg acgccagccg cgccagatgc     1680

acggtgggcg agatcaccga cgccctgaag aaggtcttcg gcgagcataa ggccaacgac     1740

aggatggtgt ccggggccta caggcaagag tttggggagt ccaaagagat cacctcggcc     1800

atcaagcggg tgcacaagtt catggaaagg gaaggcaggc ggcccaggct gctcgtagcc     1860

aagatgggtc aagacggcca cgacaggggc gccaaagtca tcgccaccgg ctttgccgac     1920

ctgggtttcg acgtggatat cggcccgctg ttccagaccc ccagggaggt ggcccagcag     1980

gcggtggacg ccgacgtaca tgccgtgggc gtgtccaccc tggcggccgg ccacaagacg     2040

ctggtgcccg agctgatcaa ggagctcaac agcctgggaa ggcccgacat cctggtcatg     2100

tgcggcggcg tgatcccgcc ccaggattac gagttcctgt ttgaggtggg ggtgtccaac     2160

gtctttggcc ccggcaccag gatccccaag gcggccgtgc aggtgctgga cgatatcgag     2220

aaatgtctcg aaaagaagca gcagtccgtg                                      2250


<210>  738
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  738
atgcttcgag ccaagaacca gctgttcctc ctcagccccc actacctccg gcaggtcaag       60

gaaagcagcg gctcccggct gatccagcag aggctgctcc atcagcagca gcccctgcac      120

cccgagtggg cggccctggc caagaagcag ctcaagggca aaaaccccga ggacctgatc      180

tggcataccc ccgagggcat aagcatcaaa cccctgtaca gcaagaggga caccatggac      240

ctcccggagg agctgcccgg tgtgaagccc ttcaccaggg gcccttatcc gaccatgtac      300

accttcaggc cctggaccat caggcaatat gccgggttca gcaccgtgga ggagagcaac      360

aagttctata aggataacat caaggccggc cagcaaggcc tcagcgtagc cttcgacctg      420

gccacccata ggggatacga cagcgacaat ccccgggtgc ggggcgacgt ggggatggcc      480

ggcgtggcga tcgataccgt ggaggacaca aaaatcctct tcgacgggat ccccctggag      540

aaaatgagcg tgtccatgac catgaacggc gcggtgatcc cggtgctggc caattttata      600

gtcaccgggg aggagcaagg cgtacccaag gagaagctga ccgggaccat ccagaacgac      660

atcctgaagg agttcatggt caggaacacc tacatcttcc ccccagagcc gagcatgaag      720

atcatcgccg acatatttga gtacaccgcc aagcacatgc ccaagttcaa cagcatcagc      780

ataagcggct accatatgca ggaggccggc gccgacgcca tcctggagct ggcctacacc      840

ctggccgacg gcctcgagta ttccaggacc gggctgcagg ccggactgac catcgacgag      900

ttcgcgcccc ggctgtcctt cttctggggg atagggatga acttctacat ggagatcgcc      960

aagatgaggg ccggccggcg gctgtgggcc cacctgatcg aaaagatgtt ccagcccaag     1020

aactcaaaaa gcctgttgct gcgcgcccac tgccagacct ccgggtggtc acttaccgaa     1080

caggacccct ataataacat cgtcaggacc gccatcgagg ccatggccgc cgtgtttggc     1140

ggcacccagt ccctccacac gaactctttc gacgaggccc tggggctccc gaccgtgaag     1200

agcgcgagga tcgcaaggaa cacccagata atcatccagg aggaaagcgg catccccaag     1260

gttgccgacc cctggggcgg cagctatatg atggagtgcc tgaccaacga cgtctacgat     1320

gcggccctga agctgatcaa cgaaatcgaa gagatgggcg gaatggccaa ggccgtggcc     1380

gagggtatcc ccaagctccg gatcgaggag tgcgccgccc gccgacaggc caggatcgac     1440

agcgggtccg aggtgatcgt gggggtgaac aagtaccagc tggaaaagga ggacgccgtg     1500

gaggtgctgg ccatcgacaa cacctcagtg aggaataggc agatcgaaaa gctgaagaag     1560

atcaaaagct ccagggacca ggccctggcc gagaggtgcc tggccgcact caccgagtgc     1620

gccgcctccg gcgacggaaa catcctcgcc ctggccgtgg acgcctcccg agccaggtgc     1680

accgtcgggg agatcaccga tgccctgaag aaggtgtttg gcgagcacaa ggccaacgac     1740

aggatggtgt cgggcgccta caggcaagag ttcggggaga gcaaggagat cactagcgcc     1800

atcaagaggg tgcacaagtt catggagcgg gagggccgga ggccccgtct gctggtggcc     1860

aagatgggcc aggacgggca cgaccgcggc gccaaggtga tcgccaccgg cttcgccgac     1920

ctggggtttg acgtggacat cggccccctg ttccagaccc ccagggaggt agcccagcaa     1980

gccgtggacg ccgacgtgca cgccgtggga gtgagtaccc tggccgccgg ccacaagacc     2040

ctggtgcccg agctgattaa agagcttaac agccttggcc ggcccgacat cctggtgatg     2100

tgcggtggcg tcatcccgcc ccaggactac gagttcctgt tcgaagtggg cgtgtccaac     2160

gtgttcggcc cgggcacccg catccccaag gccgccgtgc aggtgctcga cgacatcgag     2220

aaatgtctgg agaagaagca gcagtccgtg                                      2250


<210>  739
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  739
atgctgaggg ccaagaacca gctgttcctc ctgagccccc actacctgag gcaagtgaag       60

gagtcctccg gctccaggct gatccagcag cgactgctgc accagcagca gcccctccac      120

cccgagtggg ccgctctcgc caagaagcag ctgaagggca agaaccccga ggacctgata      180

tggcacaccc cggagggcat ctcgatcaag cccctgtatt ccaaacggga cactatggac      240

ctgccggagg agctgcccgg cgtcaagccc tttacgcggg gcccctaccc caccatgtac      300

accttccgac cgtggaccat caggcagtac gccggcttta gcaccgtgga ggagtccaac      360

aagttctaca aggacaacat caaggccggc cagcagggcc tgagcgtggc gttcgacctg      420

gccacacaca ggggctacga cagcgacaac cccagggtga ggggcgacgt gggcatggcc      480

ggggtggcca tcgacaccgt ggaggacacc aagatcctgt tcgacggcat ccccctggag      540

aagatgagcg tgagcatgac aatgaatggg gccgtgatcc ccgtgctggc caatttcatc      600

gtcaccgggg aggaacaggg cgtgcctaag gaaaagctga caggcaccat ccagaacgac      660

atcctcaagg agttcatggt gcggaacacc tacatcttcc cccccgagcc cagcatgaag      720

atcattgcag acatctttga gtacaccgcc aagcacatgc ccaagttcaa cagcatctcc      780

atctcgggct accacatgca ggaagcgggg gcggacgcca tcctcgagct ggcctatacg      840

ctggctgatg gcctggagta ctccaggact ggtctgcagg cgggcctgac gatcgacgag      900

tttgcaccca ggctatcctt cttttgggga atcggcatga acttttacat ggagatcgcc      960

aaaatgcggg cgggccgccg cctgtgggcc cacctgatcg aaaagatgtt tcagcccaag     1020

aactccaaga gcctgctgct gagggcccac tgccagacct ccgggtggag cctgactgag     1080

caggacccat acaacaacat cgtgcggacc gcgatcgagg ccatggccgc cgtgttcggc     1140

ggcacccaga gcctgcacac caattctttc gacgaggccc tgggactccc caccgtgaag     1200

tccgccagga tcgccaggaa tacccagatc atcatccagg aggagtccgg catacccaag     1260

gtggccgacc cgtggggcgg tagctacatg atggagtgcc tgaccaacga cgtctacgac     1320

gccgccctga agctgatcaa cgagatcgag gaaatgggcg gcatggccaa agcggtcgcc     1380

gaagggatcc cgaagctgag gatcgaagag tgcgccgcca ggcggcaggc caggatcgac     1440

agtggctccg aggtgatcgt gggcgtgaac aaataccagc tggagaagga ggatgccgtt     1500

gaggtgctcg ccatcgataa cacctccgtg cggaatcggc agatcgagaa gctgaaaaag     1560

atcaaaagca gccgggacca ggccctcgcg gagaggtgtc tggccgccct gaccgagtgc     1620

gccgcgagcg gcgacgggaa catcctcgcc ctggccgtgg acgcctcacg ggcccgatgc     1680

accgtgggcg agatcaccga cgccctcaag aaggtgttcg gggagcataa ggcgaacgac     1740

aggatggtgt caggggccta caggcaggag ttcggggagt ccaaggaaat tacctccgcc     1800

atcaagagag tccacaaatt catggaacgg gagggcagga ggcccaggct gctggtggcc     1860

aagatgggtc aggacggcca cgacaggggc gccaaggtga tcgccaccgg gttcgccgac     1920

ctcgggttcg atgtcgacat cgggcccctg ttccagaccc ccagggaagt ggcccaacag     1980

gccgtggacg ccgacgtgca cgccgtgggc gtgagcaccc tggccgccgg acacaagacc     2040

ctggtgcccg agctgataaa ggagctgaac agcctggggc gacccgacat cctcgtgatg     2100

tgcggtgggg tgatcccgcc gcaggactac gagttcctgt tcgaggtggg cgtgtccaac     2160

gtgtttgggc ccgggacccg gatcccgaag gccgccgtgc aggtgctgga tgatatagag     2220

aagtgcctgg agaagaagca gcagagcgtg                                      2250


<210>  740
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  740
atgctgcgcg ccaagaacca gctgttcctg ctgtccccgc attacctgag gcaggtgaag       60

gagtccagcg ggtcccgtct gatccagcag aggctgctgc accagcagca gcccctgcac      120

cccgagtggg ccgctctggc taagaagcag ctgaagggta aaaaccccga ggacctgatc      180

tggcacaccc ccgaaggcat ctccatcaag cccctctaca gcaagaggga tactatggac      240

ctgcccgagg agctgcccgg cgtcaagccc tttaccaggg gcccctatcc gaccatgtac      300

acgtttcgcc cctggaccat caggcagtac gctggcttca gcaccgtgga ggaaagcaat      360

aagttttaca aggacaacat caaggccggg cagcagggtc tgagcgtggc cttcgacctc      420

gccacccacc gcggctacga ctccgacaac ccccgggtgc ggggcgacgt gggcatggcc      480

ggggtggcca tcgacaccgt ggaggacacc aagatactct tcgatgggat ccccctggag      540

aagatgtcag tctcgatgac catgaacggc gccgtgattc ccgtgctggc caactttatc      600

gtgaccgggg aagagcaggg ggtgcccaaa gaaaaactga ccgggaccat tcagaacgat      660

atcctcaagg agtttatggt gcgcaatacc tacatcttcc cccccgaacc cagcatgaag      720

atcatcgcgg acatctttga gtataccgcc aagcacatgc cgaagttcaa tagcataagc      780

atttccggtt atcacatgca ggaagccggc gccgatgcga tcctggagct ggcctacacc      840

ctggccgatg gcctcgagta ctcccgaacg gggctgcagg ccgggctcac gatcgatgag      900

ttcgccccca ggctgtcctt cttctgggga atcggcatga acttttacat ggagatcgcc      960

aagatgaggg ccggcaggcg actgtgggcg cacctgattg aaaaaatgtt tcagcccaag     1020

aactcgaaga gcctcctact gcgggcccac tgccaaacca gcggctggag cctgaccgag     1080

caagacccct acaacaatat cgtgaggacc gccatagagg cgatggccgc cgtgttcgga     1140

gggacccaga gcctgcacac caactccttc gacgaggccc tgggcctgcc caccgtgaag     1200

agcgccagga tcgcccgcaa cacccagatc atcatccagg aggaaagcgg catccccaag     1260

gtggccgacc cctggggtgg ctcctacatg atggagtgcc tgaccaacga cgtctacgac     1320

gccgcgctga agctcataaa cgagatagag gagatgggcg ggatggccaa ggccgtggcc     1380

gagggcatcc ccaaactgag gatcgaggag tgcgccgcca ggaggcaggc ccgcatcgac     1440

tccgggagcg aggtaatcgt gggcgtgaac aagtaccaac tggagaagga ggacgccgtc     1500

gaggtgctgg ccatcgacaa cacctccgtg cgaaacaggc agatcgagaa gctgaaaaag     1560

atcaagagct caagagacca ggcactggct gagaggtgcc tggccgccct caccgagtgc     1620

gcagccagcg gcgacggcaa catactggcc ctggccgtgg acgcaagcag ggcccgttgc     1680

accgtgggcg agatcaccga cgccctgaag aaagtgttcg gcgagcacaa ggcgaacgac     1740

cggatggtga gcggcgcgta caggcaggag ttcggcgaat ccaaggagat cacctccgcc     1800

atcaagcgag tgcacaagtt tatggagcgg gagggccgcc gccccaggct gctggtcgcg     1860

aagatgggac aggacggaca cgacaggggc gccaaagtga tcgccaccgg cttcgccgac     1920

cttggattcg acgtggacat aggccccctg ttccagaccc cccgagaggt ggcgcagcaa     1980

gccgtagatg ccgatgtgca tgccgtgggt gtgtccaccc tggcggccgg ccacaaaacc     2040

ctggtgcccg agctgatcaa ggagctgaac tccctgggcc ggcccgacat cctcgtgatg     2100

tgcgggggcg ttatcccccc gcaggactat gagttcctgt tcgaagtcgg ggtgtccaac     2160

gtgttcggcc ccggcacgag gatccccaag gccgccgtgc aagtcctgga cgacatcgaa     2220

aagtgcctgg agaagaagca gcaaagcgtg                                      2250


<210>  741
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  741
atgctgcggg ccaagaatca gctgttcctg ctgagccccc actacctgag gcaggtgaaa       60

gagtcctccg gctccaggct gatccagcag cgactgctgc atcagcaaca gccgctgcac      120

cccgagtggg ccgccctggc caagaagcag ctgaagggca agaatcccga ggacctgatc      180

tggcacaccc cggaaggcat cagcatcaag cccctgtaca gcaaacgcga tacgatggac      240

ctgccggagg agctgccggg cgtgaagccg ttcacccgcg ggccctaccc caccatgtac      300

acctttcgcc cctggaccat ccggcagtac gccggcttca gcacggtcga ggagagcaac      360

aagttctaca aagacaacat caaggccggc cagcagggcc tctccgtcgc cttcgacctg      420

gccacccaca ggggttacga cagcgataat ccacgggtga ggggcgacgt ggggatggct      480

ggggtggcca tcgacaccgt ggaggatacc aagatcctgt tcgacggcat ccccctggag      540

aagatgagcg tgagcatgac catgaacggc gccgtcatcc ccgtgctggc caacttcatc      600

gtgaccggcg aggagcaagg ggtgcccaaa gagaagctca ccggaaccat ccagaacgac      660

atcctgaagg agttcatggt ccggaacacc tacatatttc cccccgagcc cagcatgaag      720

atcatcgccg atatcttcga gtacaccgcc aagcacatgc ccaagttcaa cagcatctcc      780

atctccggct accacatgca ggaggcaggg gccgatgcca tcctggagct ggcctatacc      840

ctggccgacg gcctggagta cagccggacc ggcctccagg ccggtctgac catcgatgag      900

ttcgccccca ggctgtcgtt tttttggggc atcggcatga acttctacat ggaaatcgcc      960

aagatgaggg ccggccggag gctgtgggcc cacctgatcg agaagatgtt ccagcccaaa     1020

aacagcaagt ccctgctcct gcgtgcccac tgccagacca gcgggtggag cctgacggag     1080

caggacccct acaacaacat cgtgaggacg gccatcgagg ccatggccgc cgtttttggc     1140

ggcacccaga gcctgcacac aaacagcttc gacgaggccc tgggactgcc caccgtgaag     1200

tcggcccgga tcgcccgaaa cacccagatc atcatacagg aggaaagcgg catccccaag     1260

gtggccgacc cctggggggg aagctacatg atggagtgcc tgaccaacga cgtgtacgac     1320

gctgccctga aactgatcaa tgagatcgag gagatgggcg gcatggccaa ggccgtggcc     1380

gaagggatcc cgaagctgcg gatcgaggaa tgcgcggccc ggaggcaggc caggatcgac     1440

agcggcagcg aagtgatcgt gggggtcaat aaatatcagc tggaaaagga ggatgcggtc     1500

gaagtcctgg ccatcgacaa caccagcgtg cggaaccgcc agatagagaa gctgaaaaag     1560

atcaagtcca gccgggacca ggccctggcc gaaaggtgtc tcgccgccct caccgagtgc     1620

gcggcaagcg gggacggcaa catcctggcc ctggccgtgg acgccagccg agccaggtgc     1680

accgtgggtg aaataaccga cgccctgaag aaggttttcg gcgagcacaa ggccaacgac     1740

cgtatggtga gcggcgccta tcggcaggaa ttcggcgagt ccaaggagat cacctccgcc     1800

atcaagaggg tgcacaagtt catggagcgc gagggacggc gaccgcggct gctggtggcc     1860

aagatgggcc aagacgggca cgacaggggc gccaaggtga tcgccaccgg attcgcggac     1920

ctggggttcg acgtggacat cgggcccctg ttccagaccc cacgggaggt ggcccaacag     1980

gccgttgatg cggacgtgca cgcggtgggc gtctccaccc tggccgccgg ccacaagacc     2040

ctcgtgccag agctgatcaa ggagctgaac agcctgggca gaccagatat cctggtcatg     2100

tgcggggggg tgatcccgcc ccaggactac gagttcctgt tcgaggtggg cgtgagcaat     2160

gttttcggcc ctgggaccag aatccccaag gccgccgtgc aggtgctgga cgacatcgaa     2220

aagtgcctcg agaagaagca gcagagcgtg                                      2250


<210>  742
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  742
atgctgaggg ccaagaacca gttgtttctg ctctcccccc actacctgag gcaggtgaaa       60

gaaagctccg gcagcaggct gatccagcag aggctcctgc accagcagca accgctccat      120

cccgagtggg cagccctggc gaagaaacag ctgaaaggga agaaccccga ggatctgatc      180

tggcacaccc ccgaggggat cagcatcaag ccgctgtaca gcaaacggga caccatggat      240

ctgcccgaag agctgccggg cgtgaagccc ttcaccaggg ggccctaccc caccatgtat      300

accttcaggc cctggaccat acggcagtac gccggcttct ccactgtgga agagtcgaat      360

aagttctaca aggataacat caaggccggc caacagggcc tgagcgtggc ctttgacctg      420

gccacccatc gcgggtatga cagtgataac cctcgggtgc gtggcgacgt gggtatggcc      480

ggcgtggcca ttgacaccgt ggaggacacg aagatcctct tcgacggcat ccccctggag      540

aagatgagcg tgagcatgac catgaacggc gccgtgattc ccgtgctcgc caatttcatc      600

gtcaccggcg aggagcaggg cgtgcctaag gagaagctga ccgggaccat ccagaatgac      660

atcctgaagg agtttatggt gaggaacacc tacatcttcc cgcccgaacc cagcatgaag      720

atcatcgccg acatcttcga gtacacagcc aagcacatgc ccaagttcaa ctccatcagc      780

atctccggat accatatgca ggaagccggg gccgatgcga tccttgagct ggcctatacc      840

ctggccgacg gcctggagta ctccaggacc ggcctgcaag ccgggctgac aatcgatgag      900

ttcgcccccc gactgagctt cttctggggc atcggcatga acttttacat ggagatcgcc      960

aaaatgcggg ctgggaggag gctctgggcc cacttgatcg agaagatgtt tcagcccaag     1020

aactccaaga gcctgctcct gagggcccac tgccagacga gcggttggtc cctcaccgag     1080

caggacccct acaacaacat cgtgaggacc gccatcgagg ccatggccgc cgtgttcggc     1140

gggacgcaga gcctccacac caactccttt gacgaggccc tggggctgcc cacggtcaag     1200

agcgcacgca tagccaggaa cacccaaatc atcatccagg aggagagcgg aatccccaag     1260

gtcgcggacc catggggggg aagctacatg atggagtgcc tgaccaacga cgtatacgac     1320

gccgccctga aactgatcaa tgagatagaa gagatggggg gaatggccaa agccgtggcc     1380

gagggcatcc cgaagctgag gatcgaagaa tgtgccgcca ggaggcaggc ccggatcgac     1440

agcggcagcg aggtcatcgt cggggtgaat aaataccaac tggagaagga ggacgccgtg     1500

gaggtcctgg ccatcgacaa tacaagcgtg cgcaatcggc agattgagaa gctgaagaag     1560

atcaagagca gcagggacca ggcgctggca gagcggtgtc tggccgccct gaccgaatgc     1620

gccgccagcg gggacggaaa catcctggcc ctggccgtgg atgcctcccg ggccaggtgc     1680

accgtcggcg agatcaccga cgctctgaag aaggtcttcg gcgagcacaa ggctaacgac     1740

cggatggtga gcggcgccta ccggcaggag ttcggcgaga gcaaggagat cacctccgcc     1800

atcaagcggg tgcacaagtt tatggaacgc gagggccgca gacccaggct cctcgtggcc     1860

aagatgggcc aggatggcca cgacaggggg gccaaggtca tcgccaccgg attcgccgat     1920

ctgggcttcg acgtggacat cgggcccctg tttcaaacgc cccgcgaagt agcacagcag     1980

gccgtggacg ccgacgtgca cgccgtgggc gtgtccaccc tggccgccgg ccataagacc     2040

ctggtgcccg agctgatcaa ggagctgaac agcctggggc gcccggatat actcgtgatg     2100

tgcgggggcg tcatcccccc ccaggattac gagtttctct tcgaggtggg ggtgagcaac     2160

gtctttggcc ccggaacccg aatccccaag gccgccgtgc aggtgctcga cgatatagag     2220

aagtgcctgg agaaaaagca gcagtccgtg                                      2250


<210>  743
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  743
atgctgaggg ccaagaacca gctcttcctg ctgtcccccc actacctgcg gcaggtgaag       60

gagagctccg gcagccgcct gatccaacag cggctgctgc accagcagca accgctgcac      120

cccgagtggg ccgccctggc caagaaacag ctcaagggga agaaccccga ggacctgatc      180

tggcacaccc ccgagggcat ttccatcaaa cccctgtaca gcaagaggga caccatggac      240

ctgcccgagg aactgccggg agtgaagccc ttcacccgcg gcccctatcc caccatgtac      300

accttcaggc cgtggaccat ccgccagtat gccggcttta gcaccgtgga ggagagcaac      360

aagttctaca aagacaacat caaggcaggg cagcagggcc tgagcgtggc cttcgatctg      420

gccacccata ggggctacga cagcgacaac ccgagggtga ggggggacgt gggcatggcc      480

ggcgtggcca tcgataccgt ggaggatacc aagatcctgt ttgacggcat ccccctggag      540

aagatgtccg tgagtatgac catgaacggc gcggtgatcc cggtgctggc caacttcatc      600

gtgaccggcg aggaacaggg cgtgccaaag gagaagctga ccggcaccat ccagaacgac      660

atactcaaag agttcatggt acggaacacc tacatcttcc cccccgagcc ctcgatgaag      720

atcatcgccg acatcttcga gtacaccgcc aagcacatgc ccaagttcaa ctccatctcc      780

atctcgggct atcacatgca ggaagccggg gccgacgcca tcctggaact ggcctacact      840

ctggccgacg gcctcgagta ctccaggacc ggcctgcaag cgggcctgac catcgacgag      900

ttcgcccccc ggctgtcttt tttttgggga atcggcatga acttctacat ggagatcgcc      960

aagatgaggg ccggtcgccg gctctgggcc cacctgatcg agaagatgtt ccagcccaag     1020

aacagcaaga gcctcctgct gagggcccac tgccagacca gcggctggag cctgactgag     1080

caagatccct acaacaacat cgtgcggacg gccatcgagg cgatggctgc cgtcttcggc     1140

ggaacccaga gcctgcatac caacagcttc gatgaagccc tggggctgcc caccgtgaag     1200

tccgcgagga tcgccaggaa cacgcagatc attatacagg aggagagcgg gatccccaag     1260

gtggcagatc cctggggcgg aagctacatg atggagtgcc tgaccaacga cgtgtacgac     1320

gcggcgctga agctgattaa cgagatcgag gaaatgggag gcatggccaa ggccgtggcc     1380

gagggcattc ccaaactccg gatcgaggag tgtgcagcca ggcgacaagc caggatcgac     1440

agtggctccg aggttatcgt cggcgtgaac aagtaccagc tggagaaaga ggacgccgtg     1500

gaggtcctgg ccatcgacaa cacaagcgtg aggaaccggc aaatcgaaaa gctgaagaag     1560

atcaaaagca gccgggacca ggccctcgcc gagcgctgtc tggccgccct caccgagtgt     1620

gctgccagcg gtgacggcaa tatcctggcc ctggccgtgg atgccagccg cgcccggtgc     1680

accgtcggcg aaatcaccga tgccctgaag aaagtgttcg gggagcacaa ggccaacgac     1740

cgcatggtgt ccggcgccta tcggcaggag ttcggcgaga gcaaggaaat aaccagcgcc     1800

atcaagcggg tgcacaaatt catggagcgg gagggccggc ggcccaggct gctggtcgcc     1860

aagatgggcc aggacgggca cgacagggga gctaaggtga tcgcgacggg gttcgccgat     1920

ctgggctttg acgtggatat cggacccctc ttccagacac cgcgggaggt ggcccagcag     1980

gccgtggacg ccgacgtgca tgccgtcggc gtgagcacac tggccgccgg acacaagact     2040

ctggtgcccg agctcatcaa ggagctgaac agcctcggac ggcccgatat cctcgtgatg     2100

tgcggtggcg tgatcccccc gcaggactac gaatttctct ttgaggtggg cgtgagcaac     2160

gtgttcggcc ccggcacgag gatccccaaa gccgccgtgc aggtgctgga cgacatcgag     2220

aagtgtttgg agaagaagca gcagtccgtg                                      2250


<210>  744
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  744
atgctgaggg ccaagaacca gctgtttctc ctgagccccc actacctcag gcaggtgaag       60

gagagctccg gctcaaggct gatccagcaa cgtctgctgc atcagcagca acccctgcac      120

ccagagtggg ccgccctcgc caagaagcag ctgaagggca aaaaccccga ggatctgatc      180

tggcacaccc ccgagggcat cagcatcaag cccctgtact ccaagaggga tacaatggac      240

ctgccggagg agctgcccgg agtgaaaccc ttcaccagag gcccctaccc caccatgtac      300

acctttaggc cctggaccat acggcagtac gccgggttca gcaccgtgga ggagagcaat      360

aaattctaca aggacaacat aaaggccgga cagcagggcc tgtccgtggc cttcgacctg      420

gccacccaca ggggctatga cagcgataac ccccgcgtga ggggggacgt cggcatggcc      480

ggagtagcca tcgataccgt ggaggatacc aagatcctgt tcgacggcat ccccctcgag      540

aagatgagcg tgtccatgac catgaatggc gcagtgatcc ccgtgctggc caacttcatc      600

gtgaccggtg aggagcaggg cgtgcccaag gagaaactga ccgggaccat ccagaacgac      660

atactgaagg agtttatggt gcggaacacg tacatattcc cccccgagcc cagcatgaag      720

atcatcgccg acatcttcga atataccgcc aagcacatgc ccaagttcaa cagcattagc      780

atctcaggct accacatgca ggaggccggc gccgacgcga tcctggagct ggcctacacc      840

ctggccgacg gcctggagta cagccggacc ggcctgcagg caggcctgac catcgacgaa      900

ttcgcccccc ggctctcctt cttctggggg atcggcatga acttttacat ggagatcgcc      960

aaaatgcggg ccggccggcg gctctgggcc cacctgatcg aaaagatgtt ccagcccaag     1020

aacagcaaga gcctgctgct gagggcccac tgccagacga gcggctggag cctgaccgag     1080

caagacccct acaacaacat cgtgcgcacc gccatagagg ccatggccgc cgtgttcggg     1140

ggtacacaaa gcctccacac taacagcttc gacgaggccc tgggtcttcc cacggtgaag     1200

tcagcgcgca ttgcccgcaa cacccagatc atcatccaag aagagtccgg catccccaag     1260

gtggccgacc cctggggcgg gagctacatg atggaatgcc tcaccaacga cgtgtatgac     1320

gcggcgctca agctgatcaa cgagatcgaa gaaatgggcg gcatggcaaa ggccgtggcc     1380

gagggcatcc ctaagctgag aatcgaggag tgcgcagcca gacggcaggc caggattgac     1440

agcggcagcg aggtaatcgt gggagtgaac aagtatcagc tggagaagga ggacgccgtg     1500

gaagtgctgg ccatcgacaa cacctccgtg aggaatcgac agatcgagaa gctgaagaag     1560

atcaagtcca gccgggacca ggccctggcc gagaggtgcc tggccgccct gaccgagtgt     1620

gccgccagcg gggacggcaa catccttgcc ctggccgtgg acgcgtccag ggcccgctgt     1680

accgtgggcg agatcaccga cgccctgaag aaggtgtttg gggagcacaa ggccaatgat     1740

cgcatggtgt ccggcgcgta ccggcaggag ttcggagaga gcaaggagat cacctccgcc     1800

attaagaggg tgcacaagtt catggaaagg gagggccgga ggccccgcct actggtggcc     1860

aaaatgggcc aagacggcca cgacagggga gccaaggtga tcgccaccgg gttcgcggac     1920

ctgggctttg acgtcgacat cggccccctg tttcagaccc ccagggaagt ggcgcagcag     1980

gcggtggacg ccgatgtgca cgccgtgggc gtgagcacac tggcagccgg ccacaagact     2040

ctggtgcccg agctgataaa agagctgaac tctctgggca ggcccgacat cctggtgatg     2100

tgcggcggcg tcatcccccc ccaagactac gagttcctgt tcgaggtggg cgtaagcaat     2160

gtgttcggcc ccggcacccg aattcccaag gcggccgtgc aagtgctgga cgacatcgag     2220

aagtgcctcg agaagaagca gcagagcgtc                                      2250


<210>  745
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  745
atgctcaggg ccaagaatca gctgttcctg ctcagccccc attacctgag gcaggtgaag       60

gaatcgtccg ggtcccgcct catccagcag cgactcctgc accagcagca gccactacac      120

cccgagtggg ccgccctggc caagaagcag ctgaaaggca agaaccccga ggatctcatc      180

tggcacacgc ccgagggcat cagcatcaaa cccctgtatt ccaagcgtga caccatggac      240

ctgcccgagg agctgcctgg tgtcaagccc ttcacccggg ggccctaccc gacgatgtac      300

acctttcgtc cctggaccat caggcagtac gccggcttca gcaccgtaga ggagagcaac      360

aagttctaca aagacaacat caaagccggt cagcaagggc tgtccgtggc cttcgacctg      420

gccacgcacc gcggctatga cagcgacaac ccccgagtca gaggggacgt ggggatggcc      480

ggggtggcaa tcgataccgt cgaggacacc aagattctgt tcgatggcat tcccctggag      540

aagatgagcg tcagcatgac catgaatgga gccgtgatcc ccgtgctggc caacttcatc      600

gtgactggtg aggaacaggg cgtgcccaag gagaagctga ccgggaccat ccagaacgac      660

atcctgaagg agtttatggt tcgcaatacc tacatattcc cccccgagcc cagcatgaag      720

atcatcgccg atatcttcga atataccgcc aaacacatgc ccaagtttaa tagcatcagc      780

atcagcggct accacatgca ggaagccggg gccgacgcca tcctggagct ggcatacact      840

ctggccgacg gcctggagta cagccgcacc ggcctccaag cagggctcac gatcgacgag      900

ttcgccccac ggctcagctt cttctggggg atcggcatga atttctacat ggagatcgcc      960

aagatgaggg ccggtcggag gctttgggcc catttgatcg aaaaaatgtt ccaacccaag     1020

aatagcaaat ccctgctgct cagggcccac tgccagacca gcggctggtc actgaccgaa     1080

caggacccat acaacaatat cgtgaggacc gccatcgagg ccatggcggc ggtgttcggc     1140

ggcacccaga gcctccacac caacagtttt gacgaggccc tgggactgcc gaccgtgaag     1200

agcgcccgga tcgcgcgcaa cacgcagatt atcattcagg aggagtccgg catccccaag     1260

gtcgccgacc cctggggcgg cagctacatg atggaatgcc tgaccaacga cgtgtacgac     1320

gccgccctca agctcatcaa tgagatcgag gagatgggcg ggatggccaa ggccgtggcc     1380

gagggcatcc ccaagctgcg aatcgaagaa tgcgccgcca ggcggcaggc ccggatcgac     1440

tccggctccg aggtcatcgt cggcgtcaac aagtaccagc tcgagaagga ggatgccgtg     1500

gaggtgctgg ccatcgataa cacgtccgtg aggaaccggc agattgagaa gctgaagaag     1560

atcaagagct cccgagacca ggccctggcc gagaggtgcc tggccgccct gactgagtgc     1620

gccgcctccg gggacgggaa catcctggcc ttggctgtgg acgcgagcag ggccaggtgc     1680

accgtgggcg aaatcaccga cgccctcaag aaggtcttcg gcgagcacaa ggccaatgac     1740

cggatggtca gcggtgccta caggcaggag ttcggtgaat ccaaggagat cacctcggcc     1800

ataaaaagag tccacaagtt tatggagagg gaagggcgta ggccccgact cctggtggcc     1860

aagatgggcc aagacggcca cgaccggggc gccaaggtca tcgccaccgg gttcgccgac     1920

ctggggttcg acgtcgacat cgggcccctg ttccagaccc cacgagaggt ggcccagcag     1980

gccgtcgacg ccgacgtgca cgccgtgggc gtctccacgc tggcggccgg ccacaaaacc     2040

ctcgtgcccg agctgatcaa ggagctgaat tccctcggcc ggcccgacat cctggtgatg     2100

tgcggggggg tcatcccccc ccaagattac gagttcctgt tcgaggtggg cgtgagcaac     2160

gtgttcggcc ccggcaccag gatccccaag gccgccgtgc aggtgctgga cgacatcgag     2220

aagtgcctcg agaagaagca gcagtccgtg                                      2250


<210>  746
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  746
atgctgaggg ccaagaacca gctattcctg ctgagcccac actacctccg gcaggtgaag       60

gagagcagcg gaagcaggct gatccagcag cggctgctcc accagcagca accactgcac      120

cccgagtggg ccgccctcgc caagaaacaa ctgaagggca agaaccccga agacctaatc      180

tggcacactc cagagggtat cagcatcaag cccctgtact ccaagagaga caccatggac      240

ctgcccgagg aactgcccgg cgtcaagccc tttaccaggg gcccctaccc caccatgtat      300

accttccgac cctggaccat caggcagtac gccgggttca gcacggtgga ggagtccaat      360

aagttctaca aggataacat caaggccggt cagcagggtc tgtccgtggc cttcgacctg      420

gccacccacc gcggatatga cagcgacaac ccgagggtga ggggcgacgt ggggatggcc      480

ggcgtggcca tcgacaccgt ggaggacaca aagatactgt tcgacggaat cccgctggaa      540

aagatgagcg tcagcatgac catgaacggg gccgtgatcc ccgtgctggc caacttcatc      600

gttaccggtg aggaacaggg ggtgcctaag gagaagctga ccggcaccat acagaacgac      660

atcctgaagg agtttatggt gaggaacacc tatatcttcc cccccgagcc aagcatgaaa      720

atcatcgcag acatctttga gtacaccgcc aagcacatgc ccaagttcaa cagcatcagc      780

atttccggct accacatgca ggaagccggg gccgacgcca tcctcgaact ggcctacacc      840

ctggctgacg gcctggagta cagccggaca gggctgcagg ccgggcttac gatcgacgag      900

ttcgcccccc ggctgtcctt cttttggggg atcgggatga acttctatat ggagatcgca      960

aagatgaggg ccggcaggag gctgtgggcg cacctcatcg agaagatgtt ccagccgaaa     1020

aactcgaaga gcctgctgct gcgcgcccat tgccaaacaa gcggctggtc actgacagag     1080

caggacccct acaacaatat cgtgaggacc gccatcgagg ccatggccgc cgtgttcggg     1140

ggcacccaga gcctgcatac taactccttc gacgaggccc tgggtctccc cacggtgaag     1200

agcgccagga tcgccaggaa cacccagatc attatccagg aggagagcgg cattcccaag     1260

gtggccgacc cctggggggg ctcctacatg atggagtgcc tgacaaacga tgtgtacgac     1320

gccgccctca agctgatcaa cgagatcgag gagatggggg gcatggccaa ggccgtggcc     1380

gagggcatcc ccaagctgcg gatagaggag tgcgccgcca ggcgccaggc caggatcgac     1440

agcggttccg aggtgatcgt gggcgtgaac aagtatcagc tggagaagga agacgccgtg     1500

gaggtcctgg ccatcgacaa cacatcggtg agaaataggc agatcgaaaa gctcaaaaag     1560

atcaagtcca gccgtgacca agccctggcc gagaggtgtc tggcggccct gaccgagtgc     1620

gccgccagcg gcgacggcaa catccttgcc ctcgcggtcg atgccagcag ggccaggtgc     1680

accgtggggg aaatcaccga cgccctgaag aaggtgttcg gcgagcacaa agccaacgac     1740

aggatggtga gcggcgccta ccgccaagag ttcggcgagt ccaaggagat caccagcgcc     1800

atcaagcgcg tgcacaagtt catggagagg gaaggcagga ggccgcgcct gctggtggcc     1860

aagatgggcc aggacggcca cgataggggg gccaaagtca tcgccaccgg cttcgccgac     1920

ctgggcttcg acgtggacat cggccccctg tttcagaccc cccgtgaggt cgcccagcag     1980

gccgtggacg cggatgtgca cgccgtgggg gtgtccaccc tggccgccgg acataaaacc     2040

ctggtgccgg aactgatcaa ggaactgaac agcctgggac ggcccgacat actggtgatg     2100

tgcggaggcg tgatcccccc ccaggattac gagttcctgt tcgaggtggg cgtttccaat     2160

gtgttcggac cgggcacgcg gattcccaag gccgcagtgc aggtgctgga tgacatcgaa     2220

aaatgcctgg agaagaagca gcagtcagta                                      2250


<210>  747
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  747
atgctgcgcg ccaagaacca gctgttcctg ctgtcccccc actacctgcg gcaggtgaag       60

gagagctccg gcagccgtct gatccaacag cggttactgc accagcaaca gcctctgcac      120

ccagagtggg ccgccctggc caagaagcag ctcaaaggga agaaccccga ggacctgatc      180

tggcacaccc ccgaaggcat cagcatcaag cctctctata gcaagcgaga caccatggac      240

cttcccgagg agctgcccgg cgtcaagccc ttcacccgag gcccctaccc caccatgtat      300

accttccgcc cctggacaat caggcaatac gccggcttca gcaccgtgga ggagagcaac      360

aagttctaca aggacaacat caaggccggc cagcaaggcc tcagcgtggc cttcgacctg      420

gcgacccaca ggggctatga cagcgataac cccagggtca ggggggacgt gggcatggcc      480

ggggtggcca tcgacaccgt ggaagacacc aagatcctgt tcgacgggat ccccctcgag      540

aaaatgtcgg tgtccatgac catgaatgga gccgtgatcc ccgtactggc caacttcata      600

gtcaccggag aggagcaagg cgtcccaaag gagaagctga ccggcaccat ccagaacgac      660

atcctgaaag agtttatggt tagaaacacc tatatcttcc cccccgagcc ctccatgaag      720

atcatcgcgg atatcttcga atacaccgcc aagcacatgc ccaagttcaa cagcataagc      780

attagcggct accatatgca agaggccggc gccgatgcca tcctggagct ggcttacacc      840

ctcgccgatg gcctggaata cagccgaacc ggactgcagg ccgggctcac cattgacgaa      900

tttgcacccc gtctaagctt cttctggggc atcggcatga acttttacat ggagatcgcc      960

aagatgcgcg ccgggcgaag gctgtgggcc cacctgatcg agaagatgtt ccagccgaag     1020

aacagcaaga gcctcctgct gagggcccac tgccagacct ccggttggag cctgaccgag     1080

caggacccct acaataacat cgtgcgcacg gccatcgagg ccatggccgc cgtgttcggg     1140

gggacccaaa gcctgcacac caactcgttc gacgaagcgc tgggcctccc gacggtgaag     1200

tccgcccgca tcgcccggaa cacccagatc atcatccaag aggagagcgg cattcccaag     1260

gtggcagacc cctggggcgg tagctacatg atggagtgcc tgaccaatga cgtctacgat     1320

gccgccctga agctcatcaa cgagatcgag gagatgggcg gtatggccaa ggccgtggcc     1380

gaaggcatcc ccaagctgcg cattgaggaa tgcgccgccc ggaggcaagc ccggatagac     1440

agcggctccg aagtgatcgt gggcgtcaac aaataccagc tggagaagga ggacgccgtc     1500

gaggtgctgg ccattgacaa caccagcgtg aggaacaggc agatcgaaaa gctgaaaaaa     1560

attaagagct cgagggatca agccttggcc gagaggtgtc tggccgccct gaccgagtgc     1620

gccgccagcg gcgatggcaa catcctggcc ctggccgtgg acgccagccg cgcccggtgt     1680

accgtgggcg agattaccga cgccctgaag aaggtctttg gggagcacaa ggccaacgac     1740

cgaatggtga gcggcgccta taggcaggag tttggcgaaa gcaaggagat caccagcgcc     1800

atcaagcgtg tgcataagtt catggagcgg gagggccggc gcccgaggct gctcgtcgcc     1860

aagatgggcc aggatggcca tgacaggggc gccaaggtca tcgccaccgg gtttgccgac     1920

ctgggcttcg acgtggacat cgggcccctc ttccagacgc cgcgcgaagt cgcccagcag     1980

gccgtagatg ccgacgtgca cgcagtgggc gtgtccaccc tcgcagcggg gcacaagaca     2040

ctggtgcccg agctgattaa ggagctcaac tccctgggcc gacccgacat cctggtgatg     2100

tgcgggggcg tcatcccccc ccaggactat gagttcctgt tcgaggtggg cgtctccaac     2160

gtgttcggcc ccggcactag gatccccaag gccgcagtac aggtgctcga cgacatagag     2220

aagtgcctgg agaagaaaca gcagagcgtg                                      2250


<210>  748
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  748
atgctgaggg ctaagaacca gctgttcctg ctgagccccc actacctgag gcaagtgaag       60

gagtcctcgg gcagcaggct gatacagcag aggctgctgc accaacaaca gcccctgcac      120

cccgagtggg ccgccctggc caagaagcag ctgaagggga agaatccgga ggacctgatc      180

tggcacaccc cagagggcat aagcatcaaa cccctgtaca gcaagcggga taccatggac      240

ctgcccgagg agctgcccgg cgtgaagccc ttcacgaggg gcccctaccc caccatgtat      300

acctttaggc cctggaccat caggcagtat gccggcttca gcaccgtgga ggagagcaac      360

aaattctaca aggataacat aaaggccggg cagcaaggtc tcagcgtcgc cttcgatctc      420

gccacccatc ggggctacga ctcggataac ccccgcgtgc gcggcgacgt aggaatggcc      480

ggcgtcgcca tcgacaccgt ggaggacacg aagatactat tcgacggaat ccccctggaa      540

aagatgagcg ttagcatgac catgaacggg gccgtgatcc ccgtgctggc caatttcatc      600

gtgaccggcg aagagcaggg cgtgccgaag gagaagctca ccggtaccat ccagaacgac      660

atcctgaaag agttcatggt gaggaatacc tacatctttc cccccgaacc cagcatgaag      720

atcattgcgg acatcttcga gtataccgct aagcacatgc cgaagtttaa cagcatctcc      780

atcagcggct accatatgca agaggccggc gccgacgcca tcctggagct ggcgtacacc      840

ctcgccgacg gcctcgagta tagccgtacc ggcctgcagg cggggctcac catcgacgag      900

ttcgcccccc gactgagttt cttctggggc atcggcatga acttctacat ggagatcgca      960

aagatgaggg ccggccgaag gctctgggcc cacctgatcg agaagatgtt tcagcccaag     1020

aacagcaaga gcctgctgct gagggcccac tgccagacct ccgggtggtc cctgaccgag     1080

caggacccct acaataatat tgttagaacc gccatcgagg ccatggccgc agtcttcgga     1140

ggcacccaga gcctgcacac caactccttc gacgaggccc tgggcctgcc gaccgtgaag     1200

agcgccagga tcgccaggaa cacccaaatc ataatccagg aggagagcgg catccccaag     1260

gtcgccgacc cctggggcgg atcctacatg atggaatgcc tgaccaacga cgtgtacgac     1320

gccgccctga aactgatcaa tgagatcgag gagatgggcg ggatggcgaa ggccgtggcc     1380

gaggggatcc ccaagctgcg gatcgaggag tgcgccgcca ggaggcaggc ccgcatcgac     1440

agcggcagcg aagtgatcgt gggcgtcaac aagtaccagc tggagaaaga agacgccgtg     1500

gaggtgctcg caatcgacaa caccagcgta aggaatcgcc agatcgaaaa gctgaaaaag     1560

atcaaaagca gccgagacca ggccctggcc gagaggtgtc tggccgccct gaccgagtgt     1620

gccgccagcg gcgacgggaa cattctggcc ctggccgtgg atgcaagcag ggctaggtgc     1680

accgtgggcg agataaccga cgcgctgaag aaggtgttcg gcgagcacaa ggccaacgac     1740

cgcatggtgt cgggggccta tcggcaggag tttggggaga gcaaggagat tacctccgcg     1800

attaagaggg tccacaagtt catggagcgc gaaggcaggc ggccccggct gctggtggcc     1860

aagatgggcc aggacgggca cgatcgtgga gccaaagtga tcgccaccgg cttcgccgac     1920

ctgggcttcg acgtggacat cggccccctc ttccagaccc ccagggaggt ggcccagcag     1980

gccgtggacg ccgacgtcca cgccgttggc gtgtccacac tggccgccgg acacaaaacc     2040

ctggtgcccg agcttatcaa agagctgaac agcctgggca ggcccgacat actcgtgatg     2100

tgcgggggcg tgatcccccc ccaggactac gagttcctgt tcgaagtggg cgtgagcaac     2160

gtctttggcc ccggcaccag gatccccaag gccgccgtgc aggtgctcga cgatatcgag     2220

aaatgccttg agaagaagca gcagagcgtg                                      2250


<210>  749
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  749
atgctgaggg ccaagaacca gctgttcctg ctgagccccc actacctgag gcaggtgaaa       60

gaaagcagcg gcagcaggct aatccaacag cgtctgctcc accagcagca gcccctccat      120

ccagagtggg cggccctggc gaaaaagcaa ctcaagggca agaatcccga agatctcatc      180

tggcatacgc ccgaggggat cagcataaag ccgctgtaca gcaagaggga caccatggat      240

ctgcccgagg aactgcccgg cgtgaagccc tttacgcggg gcccctaccc gaccatgtac      300

accttccggc cctggaccat ccgacagtac gccgggttca gcaccgtgga ggagagcaat      360

aagttttaca aggacaatat caaagccggc cagcagggcc tgtccgtcgc cttcgacctg      420

gccacccacc gcggatatga cagcgacaac ccccgggtgc ggggcgacgt gggcatggcc      480

ggcgtggcca tcgacaccgt ggaggacaca aagatcctgt tcgacgggat acccctggag      540

aagatgagcg tcagcatgac catgaacggc gccgtgatcc cagtcctggc caacttcatc      600

gtgaccggcg aggaacaggg ggtgcccaag gagaagctga ccggcaccat ccagaatgat      660

atcctgaagg agttcatggt gcggaacacc tacatcttcc cccccgaacc gagcatgaag      720

atcatcgccg acatctttga gtacaccgcc aagcatatgc ccaagtttaa tagcatcagc      780

atcagcgggt accacatgca ggaggccgga gccgacgcca tcctcgagct cgcctacact      840

ctcgccgacg gcctcgagta cagccggacc ggactgcagg ccggcctcac catcgacgag      900

ttcgcacccc ggctgtcctt cttctggggg atcggcatga atttctacat ggagatcgcc      960

aagatgcggg ccggcaggcg cctgtgggcc cacctcatcg agaagatgtt ccagcctaaa     1020

aacagcaaga gcctgctgct gagggcgcac tgccagacct ccggctggag cctgaccgaa     1080

caggacccct ataataatat tgtccggacc gccatcgaag ccatggcagc cgtgttcggc     1140

ggtacccagt ccctgcacac caactccttc gacgaggcgc tgggcctgcc caccgtcaag     1200

tccgccagga ttgcccgtaa cacccagatc atcatacagg aggagtcagg catcccgaag     1260

gtggccgacc cctggggcgg ctcctacatg atggagtgcc tcaccaacga cgtgtacgac     1320

gccgccctga agctgatcaa cgagatcgag gagatgggcg gcatggcaaa ggccgttgcc     1380

gagggcatcc ccaagctgag gatcgaagag tgcgccgcca ggaggcaggc ccggatagac     1440

tccggcagcg aggtgatcgt cggcgtgaac aagtaccagc tggagaagga agatgccgtg     1500

gaagtgctgg ccatcgacaa tacctccgtg cgcaaccgtc agatcgagaa gctcaagaaa     1560

atcaagtcca gccgggacca ggccctggcg gaacgatgtc tggccgccct gaccgagtgc     1620

gccgccagcg gcgatggcaa tatactggcc ctggccgtgg acgccagccg cgcccggtgc     1680

accgtcgggg agatcaccga cgccctgaag aaggtgttcg gggaacacaa ggccaacgac     1740

cggatggtga gcggcgccta caggcaggag ttcggggaga gcaaggagat caccagcgcc     1800

atcaagaggg tccacaagtt catggagagg gagggcaggc ggccgcggct gttggtggcc     1860

aaaatggggc aggacgggca cgaccggggc gccaaggtca tcgccaccgg cttcgccgat     1920

ctgggttttg acgtggacat cggccccctg ttccaaaccc ccagggaggt ggcccagcag     1980

gccgtcgacg ccgacgtgca tgccgtcggc gtgtccaccc tggccgccgg gcacaagaca     2040

ctggtccccg agctcatcaa ggagctcaat tccctgggca ggcccgacat cttggtcatg     2100

tgcggcggcg tgatcccccc gcaggactat gagttcctct tcgaggttgg ggtgagcaac     2160

gtctttggcc ctgggacaag gatccccaag gccgccgtgc aggtgctgga cgacatcgag     2220

aaatgtctcg agaagaagca acagagcgtt                                      2250


<210>  750
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  750
atgctcaggg ccaagaacca gctcttcctg ctctcccccc actacctgag gcaggtgaag       60

gaatcctccg ggagcaggct gatacagcag aggctgctgc accaacaaca gcccctccac      120

cccgagtggg ccgccctggc caagaagcag ctgaaaggga agaaccccga agacctcatc      180

tggcacaccc ccgaagggat cagcatcaag ccgctgtaca gcaagcggga cacgatggac      240

ctgcccgagg agctgcccgg ggtcaaacca ttcaccaggg ggccctaccc caccatgtat      300

accttccgcc cctggacgat caggcagtac gccggctttt ccacggtgga ggagagcaac      360

aagttctaca aggataacat caaggccgga cagcagggcc tgagcgtcgc cttcgacctg      420

gccacccata ggggctacga cagcgacaac cccagggtac gtggcgacgt aggaatggcc      480

ggggtcgcca tcgacaccgt ggaagacacc aagatcctgt tcgacgggat ccccctcgag      540

aaaatgagcg tcagcatgac catgaacggg gccgtcatcc ccgtgctggc caacttcatc      600

gtgacgggcg aggagcaagg agtacccaaa gaaaagctga ccggcaccat ccagaacgac      660

atcctgaagg agttcatggt ccggaacacc tacatcttcc ccccggaacc aagcatgaag      720

atcatcgccg atatcttcga gtacaccgcc aaacacatgc ccaagttcaa ttccatcagc      780

atcagcggct accacatgca ggaggccggc gcggacgcca tcctggagct cgcctacacc      840

ctggcggacg gcctcgagta cagcaggacc ggcctgcagg caggactgac catcgacgag      900

ttcgccccca ggctgtcctt cttctggggc atcggcatga acttctacat ggagatcgcc      960

aagatgcggg ccggcaggcg gctgtgggcc cacctgatcg agaagatgtt ccagcccaag     1020

aacagcaagt cgctgctgct gcgcgcgcat tgtcagacca gcggctggtc actcaccgag     1080

caggatccgt acaacaatat cgtgcgaacc gccatcgagg ccatggccgc agtgttcggc     1140

ggcacccaga gcctgcacac caatagcttc gacgaggcgc tggggctgcc caccgtgaag     1200

agcgcccgga tcgcccgaaa cacacagatc atcatccagg aggaaagcgg catccccaag     1260

gtggccgacc cctggggggg cagctacatg atggagtgcc tgaccaacga tgtgtacgac     1320

gccgccctga agctgatcaa cgagatcgag gagatggggg gcatggccaa agccgtggcg     1380

gaggggattc ccaagctgag gatagaagag tgcgctgcca ggcgccaagc ccggatcgac     1440

agcggctcgg aggtcatcgt gggcgtgaac aagtaccagc tggagaagga ggacgcagtg     1500

gaggtcctgg ctatcgacaa cacgagcgtg aggaaccggc aaatcgaaaa actgaagaag     1560

ataaagagca gccgcgacca ggcgctggcc gagaggtgcc tggccgccct gaccgagtgt     1620

gcggcctccg gcgatggcaa catcctggcc ctcgccgtgg acgcctccag agccaggtgc     1680

accgtggggg agatcaccga cgccctcaag aaggtgttcg gggagcataa ggccaatgac     1740

aggatggtca gtggggccta ccgccaggag ttcggcgagt ccaaggagat aaccagcgcc     1800

atcaagaggg ttcacaagtt catggagagg gaaggcagac gccccaggct gctggtcgcc     1860

aagatgggcc aggacggcca cgaccgaggt gccaaggtga tcgccaccgg cttcgcggac     1920

ctgggcttcg atgtcgacat cggccccctg ttccagaccc cccgcgaggt cgcccagcaa     1980

gccgtcgacg ccgacgtgca cgccgtaggg gtgagcaccc tcgccgcggg ccacaaaacc     2040

ctggtgcctg agctcatcaa agaactcaac tccctgggaa ggcccgacat actggtgatg     2100

tgcggcggcg tgatcccccc acaggactac gagttcctct tcgaggtggg cgtgtccaac     2160

gtgttcgggc ccgggacccg gatccccaag gccgccgtcc aagtgctgga cgacattgag     2220

aaatgcctgg agaagaagca gcagagcgtg                                      2250


<210>  751
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  751
atgctgaggg ccaagaacca actgttcctg ctgtcccccc actacctcag gcaggtcaag       60

gagtcgagcg gcagcaggct gattcagcaa cggctgctgc accaacaaca gcccctgcac      120

cccgagtggg cggcgctggc gaagaagcag ctgaagggga aaaaccccga ggacctgatc      180

tggcacaccc ccgagggcat cagcataaag cccctgtata gcaaacgcga caccatggac      240

ctcccagagg agctgcccgg cgtgaagccg tttacccgcg ggccctaccc caccatgtac      300

accttcaggc cctggaccat ccgacagtac gccggtttca gcaccgtcga ggagtcaaac      360

aagttctaca aggacaatat caaggccggc cagcaaggtc tgagcgtggc cttcgacctg      420

gcgacccaca ggggctacga ttccgataat ccgagggtga ggggtgatgt gggcatggcc      480

ggcgtggcca tcgacaccgt tgaggataca aaaatcctgt tcgacggcat ccccctggag      540

aagatgtccg tgagcatgac catgaacggc gccgtcatcc ccgtgctggc caacttcatc      600

gtgacaggcg aggagcaagg cgtgcccaaa gagaagctca ccgggaccat ccagaacgac      660

atcctgaaag agttcatggt gcggaacacc tacatattcc cacccgagcc cagcatgaag      720

atcatcgccg acatcttcga gtataccgcc aagcacatgc ccaagttcaa ctccattagc      780

atctccggct atcacatgca ggaggccggc gccgacgcca tcctggagct ggcctacacc      840

ttagccgacg gcctggagta ctccaggacc ggcctccagg ccgggctgac catagatgag      900

ttcgcacccc ggctgtcctt cttctggggc ataggcatga acttctacat ggagatcgcc      960

aagatgaggg ccgggcggag actgtgggcc catctgatag aaaagatgtt ccagcccaag     1020

aacagcaaga gcctcctgct aagggcgcat tgccaaacct ccggttggag cctcaccgaa     1080

caggacccct acaacaatat agtgaggacc gccatcgaag ccatggccgc cgtgtttggc     1140

ggcacccaat ccctccacac caacagcttc gatgaggccc tggggctgcc cactgtaaag     1200

agcgcccgca tcgcacgcaa cacccagatc atcatccagg aggaaagcgg cattcccaaa     1260

gtcgccgacc cgtggggggg gtcctacatg atggagtgcc tgaccaacga cgtgtatgac     1320

gccgccctga agctgatcaa cgagatagaa gagatgggtg gcatggcaaa ggctgtcgcc     1380

gagggcatcc cgaagctgcg gatcgaagag tgcgccgcca ggaggcaagc ccggatagac     1440

tccggcagcg aggtgatcgt gggtgtgaac aagtaccagc tggagaagga ggacgccgtc     1500

gaggtgctgg ccatcgacaa caccagcgtg aggaacaggc agatcgagaa actcaagaag     1560

atcaagagca gccgcgacca agccctggcc gagcggtgtc tggccgccct gaccgagtgc     1620

gccgcttccg gcgacggaaa catcctggcc ctggccgtcg acgccagccg ggcccggtgc     1680

accgtcggcg agatcaccga tgccctgaag aaggtcttcg gggagcacaa ggccaatgac     1740

cggatggtga gtggcgctta caggcaggag ttcggcgaga gcaaggaaat cacgagcgcc     1800

atcaagaggg tccacaagtt catggagcgg gaggggagga ggcccaggct gctggtggcc     1860

aagatgggcc aggacgggca cgacaggggc gcgaaggtca tcgccacggg cttcgccgac     1920

ctggggtttg atgtcgacat cggcccactc ttccagaccc cccgggaggt ggcccaacag     1980

gccgtcgacg ccgacgtcca cgccgtgggg gtgagcaccc tggccgccgg gcacaagacc     2040

ctggtgcctg aactgatcaa ggagctgaac agcctgggca ggccagacat actggttatg     2100

tgcgggggtg tgataccccc gcaggactac gagttcctct ttgaggtggg cgtgagcaac     2160

gtgtttggcc ccggcaccag gatccccaaa gccgccgtgc aggtgctgga tgatatcgaa     2220

aagtgcctgg agaaaaagca acagtccgtg                                      2250


<210>  752
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  752
atgctgcggg ccaagaacca gctgttcctg cttagtcccc actacctccg tcaagtgaag       60

gagtcctccg ggagccggct catacagcag aggctgctcc accagcagca gcccctgcat      120

cccgagtggg ccgccctggc caagaagcag ctgaagggta aaaaccccga ggatctgatc      180

tggcacaccc ccgagggcat cagcatcaag cccctctaca gcaagcgcga taccatggac      240

ctccccgagg agctccccgg cgtgaagccc ttcacaaggg gcccctaccc caccatgtac      300

acctttaggc cgtggaccat ccggcagtat gccggcttca gcaccgtgga ggaatccaac      360

aagttctaca aagacaacat caaggcgggg caacagggcc tgagcgtggc cttcgacctg      420

gccacccata gggggtacga ctccgacaac ccgagggtga gaggcgacgt cgggatggcc      480

ggcgtggcca ttgacacagt ggaggatacc aaaatcctgt tcgacgggat acccctggaa      540

aagatgtcgg tgtccatgac catgaacggc gccgtaatcc ccgtgctggc gaacttcatc      600

gtgaccggcg aggaacaggg cgtgccaaag gaaaagctga cggggacgat ccagaacgac      660

attctcaagg aattcatggt gaggaacacc tacatctttc cccccgagcc cagcatgaaa      720

atcatcgcag acatctttga atacaccgcc aagcacatgc ccaagttcaa cagcatcagc      780

atctccggct accacatgca ggaggccggc gccgacgcca tactggaact ggcatacacc      840

ctggccgacg ggctcgagta ctccaggacc gggctccagg ccggactgac catagacgaa      900

ttcgccccac ggctgtcctt cttttggggc atcgggatga acttctacat ggagatcgcc      960

aagatgcgag ccggccgcag gctgtgggcc cacctgatag agaagatgtt ccagcccaag     1020

aactccaagt cactgctgct gagggcccat tgccagacca gcggctggag cctcaccgag     1080

caggacccct acaacaacat cgtcaggacc gccatcgagg ccatggccgc cgtcttcggc     1140

ggcacccagt ccctgcatac caactccttt gatgaggcgc tgggcctgcc cacagtgaag     1200

agcgccagga tcgccaggaa tacacagatc atcatacagg aggagagcgg catcccgaag     1260

gtggcggacc cctggggggg ctcgtatatg atggagtgcc tgaccaacga cgtgtacgat     1320

gccgccctga agctgatcaa cgagatcgaa gaaatgggcg gcatggccaa ggccgtggcc     1380

gaaggcatcc ccaagctgcg catcgaggaa tgcgccgccc gcaggcaggc caggatcgat     1440

tccggcagcg aggtgatcgt cggcgtgaac aagtaccagc tggagaaaga ggacgccgtg     1500

gaggtgctcg ccattgacaa cacctctgtg aggaatcgcc agatcgagaa actcaagaag     1560

atcaagagct ccagggacca ggcgctggcc gagcggtgcc tggccgcgct gaccgaatgc     1620

gccgcctccg gggacgggaa catcctggca ctcgcggtgg acgcctccag ggccaggtgc     1680

acggtgggcg agatcaccga cgccctgaag aaggtgtttg gcgagcacaa ggccaatgac     1740

cggatggtgt ccggcgccta taggcaagag ttcggggaga gcaaagaaat aaccagcgcc     1800

atcaagcggg tgcacaagtt tatggagagg gaaggccgcc gcccccggct gctggtcgcc     1860

aagatggggc aggacggcca cgaccgcggc gccaaggtga tagcgaccgg cttcgccgat     1920

ctgggcttcg acgtggatat cggccccctc ttccagacgc cccgggaggt ggcgcaacag     1980

gcagtggacg ccgacgtgca tgccgtgggc gtgtccaccc tggccgcagg ccacaagacc     2040

ctggtgcccg agctgatcaa ggagctgaac agcctgggta gacccgacat cctggttatg     2100

tgtggtggcg tcatcccccc ccaggactac gaatttctgt tcgaggtcgg tgtaagcaac     2160

gtgttcggcc ccggcacccg gatccccaag gccgccgtgc aggtgctgga cgacatcgag     2220

aagtgtctgg agaagaaaca gcagagcgtg                                      2250


<210>  753
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  753
atgctgcgag ccaagaacca gctgttcctc ctgagccccc actacctccg gcaggtcaag       60

gaaagctccg gttcccggct gatacagcag aggctgctgc accagcaaca acccctgcac      120

cccgagtggg ccgcacttgc caaaaaacag ctgaagggga agaaccccga ggacctgatc      180

tggcatacac ccgagggcat cagcatcaag cccctgtact cgaaacgtga caccatggac      240

ctgcccgagg agctgcccgg cgtgaagccc ttcaccaggg ggccctaccc caccatgtac      300

accttccgac cctggaccat ccggcagtac gccggcttca gcacggttga ggagtcgaac      360

aaattctata aggacaatat caaagccggc caacagggcc tgagcgtggc atttgatctg      420

gccacgcacc ggggatacga tagtgataac ccccgggtca ggggggacgt gggcatggcc      480

ggcgtagcca tcgacacggt ggaggacacc aagatactgt tcgacggcat cccactggaa      540

aagatgtccg tgagcatgac gatgaacggg gccgtgatcc cggtcctggc caacttcatc      600

gtgaccggcg aagagcaggg ggttcccaag gagaagctca ccggcaccat ccaaaacgac      660

atcctgaagg agttcatggt gcgcaatacc tacatctttc ccccggagcc cagcatgaag      720

ataatagccg acatattcga atacaccgcc aagcacatgc ccaagttcaa tagcatctcc      780

atcagcggat accacatgca ggaagccggc gccgatgcca tcctggaact ggcctacacc      840

ctggctgatg gactcgagta cagccggacc gggctgcaag ccgggctgac catcgacgag      900

ttcgccccca ggctgagctt tttctggggg atcggcatga atttttacat ggagatcgcc      960

aagatgcggg ccggcaggag gctgtgggcc cacctgattg agaaaatgtt tcaacccaag     1020

aactccaaga gcctgctgct gagggcacac tgtcaaacca gcgggtggag cctgaccgag     1080

caggacccct acaacaacat cgtaaggacg gccatcgagg ccatggccgc cgtgttcggt     1140

ggcacccaga gcctgcacac caacagcttc gacgaggccc tcgggctgcc caccgtgaag     1200

agcgcccgca tcgcccggaa tacccagatt atcatacaag aggagagcgg gatcccgaag     1260

gtggccgatc cgtggggcgg ctcctacatg atggagtgcc tgaccaacga cgtctacgac     1320

gcggcgctga agctgatcaa cgagatcgag gagatgggcg ggatggccaa agccgtggcc     1380

gagggcatcc ccaagctgcg gatcgaggag tgcgccgcca ggaggcaggc caggatcgac     1440

agcggcagcg aggttatcgt gggggtcaac aagtaccaac tggagaaaga agacgccgtg     1500

gaggtgctcg ccatcgacaa caccagcgtg aggaaccggc agattgagaa actgaagaaa     1560

atcaagagct ccagggacca ggccctggcc gagaggtgtc tggccgccct gaccgaatgc     1620

gcggccagcg gcgacggcaa catcctggcc ttggccgtgg atgccagccg agccaggtgc     1680

accgtgggag aaatcaccga cgccctgaag aaggtgttcg gcgagcataa ggccaatgac     1740

aggatggtgt ccggcgccta ccgccaggag ttcggtgagt cgaaagagat caccagcgcc     1800

atcaagcgcg tgcacaagtt catggagagg gaaggcaggc ggccgcggct gctcgtggcc     1860

aagatgggcc aagatggcca cgaccgcggt gccaaagtca tcgccaccgg gttcgcggat     1920

ctgggcttcg acgttgacat cggccccctg ttccagaccc cccgggaggt ggcccagcag     1980

gccgtggatg ccgacgtgca cgccgtgggc gtgtccaccc tggccgccgg gcacaaaacc     2040

ctggtgcccg agctgataaa ggagctgaac tccctgggaa ggcccgatat cctggtcatg     2100

tgcggcggcg tgatcccccc gcaggattac gagttcctat tcgaagtagg cgtgagcaac     2160

gtgttcggcc cggggaccag gatccccaag gcggccgtgc aggtcctgga cgacatcgag     2220

aagtgcctgg agaagaagca gcaatccgtc                                      2250


<210>  754
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  754
atgctgaggg ccaaaaatca gctgttcctg ctgagccccc actacctccg gcaggtgaag       60

gaatcctcgg ggtccaggct gatccagcag aggctgctgc accagcagca gcccctgcat      120

ccggagtggg ccgccctggc caagaagcag ctcaagggca agaaccccga ggacctgatc      180

tggcacaccc cagaaggcat ctcgatcaaa cccttgtact ccaagaggga caccatggac      240

ctacccgagg agctgcccgg ggtgaagccc ttcacccgcg gcccctatcc cacgatgtac      300

acgttcaggc cctggaccat ccgccagtac gcgggcttca gcaccgtgga ggagagcaac      360

aagttttata aagacaacat caaggccggc cagcagggcc tgagcgtggc cttcgacctc      420

gccacccacc gcggctacga cagcgacaac ccccgcgtga ggggcgacgt ggggatggcc      480

ggcgtggcga tcgacaccgt ggaggacacg aagatcctgt tcgacgggat ccccctggag      540

aagatgagcg tctccatgac catgaatggc gccgtgatcc cagtgctggc caacttcatc      600

gtgaccggcg aggagcaggg ggtcccgaaa gagaaactca ccggcaccat ccagaacgac      660

atcctgaagg agttcatggt gaggaacacc tacatcttcc ccccggaacc cagcatgaaa      720

atcatagccg acatcttcga gtacaccgcc aagcatatgc ccaaattcaa cagcatcagc      780

atatccggct accacatgca ggaggccggc gccgacgcga tcctggaact ggcctacacc      840

ctggccgacg gtctggagta cagcaggacc ggcctgcagg cgggtctcac cattgacgag      900

ttcgcgccga ggctgtcctt cttctggggc atcggcatga acttctatat ggagatagcc      960

aagatgaggg ccggcagaag gctgtgggcc catctgatcg agaaaatgtt ccagccgaag     1020

aatagcaagt ccctgctgct gagggcccac tgtcagacca gcgggtggtc cctaaccgag     1080

caggacccct acaacaacat cgtgcggacc gcgatcgaag ccatggcggc cgtgttcggg     1140

ggcacccaga gcctgcacac gaacagcttc gacgaggccc taggcctgcc aacggtgaag     1200

tccgccagga tcgcgaggaa cacgcagatc atcatccaag aggaaagcgg gatccccaaa     1260

gtggccgacc cctggggcgg tagctacatg atggagtgcc tcaccaacga tgtgtacgac     1320

gcggccctga aactcattaa tgagatcgaa gagatgggcg gcatggccaa agccgtggcc     1380

gagggcatcc ccaagctgag aatcgaagag tgcgccgcta ggcggcaagc ccggatcgac     1440

agcggcagcg aggtgatagt gggcgtcaac aagtaccaac tggagaagga agacgccgtg     1500

gaggtgctgg cgatcgacaa cacttcggtg cggaatcgtc agatagagaa gctgaagaag     1560

atcaagtcca gccgagacca ggccctggcc gagaggtgcc tggccgccct gacagagtgc     1620

gccgcctccg gcgacggcaa catcctcgct ctcgccgtag atgccagcag ggcgcgctgt     1680

accgtgggcg agatcaccga cgccctgaaa aaggtgttcg gggaacacaa ggccaacgac     1740

cggatggtgt ctggcgccta ccgccaggag ttcggggagt ccaaggagat caccagcgcc     1800

atcaagcgcg tacacaagtt catggagagg gagggcaggc gccccaggct gctcgtggcc     1860

aaaatgggac aggacgggca cgacaggggc gccaaggtga tcgcgaccgg attcgcggac     1920

ctgggcttcg acgtggacat aggacccctg ttccagaccc ccagggaggt cgcccagcag     1980

gccgtggatg cggacgtgca tgccgtgggc gtctccaccc tggccgccgg tcacaagacc     2040

ctggtgcccg agctgataaa ggagctgaac agcctgggga ggcccgacat cctggtgatg     2100

tgcggcggcg tgatcccccc ccaggattac gagttcctgt tcgaagtggg tgtatccaac     2160

gtgttcggac ccggcacccg catcccgaag gccgccgtgc aggtcctgga tgacattgag     2220

aagtgcctgg agaagaagca gcagagcgtg                                      2250


<210>  755
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  755
atgctgaggg ccaagaacca gctgttcctg ctgagccccc actatctgcg ccaggtaaag       60

gagagcagcg ggtccaggct gatccagcag aggctgctgc accagcagca gcccctccac      120

cccgagtggg ccgccctcgc caaaaagcag ctcaagggga agaaccccga agacctgata      180

tggcacaccc ccgaggggat ctccatcaaa cccctctatt ccaagaggga caccatggat      240

ctgccggagg agctgcccgg agtgaagccc tttacaaggg gcccctaccc caccatgtat      300

accttccggc cctggaccat ccgtcagtac gccggcttct cgaccgtcga ggagagcaac      360

aagttctaca aggacaacat caaggccggg cagcagggac tcagcgtggc gtttgacctg      420

gccacacata ggggctacga ctccgacaat ccccgggtga ggggcgatgt ggggatggcc      480

ggcgtggcca tcgacaccgt cgaggacacc aaaatcctgt ttgacggcat ccccctggaa      540

aagatgagcg tgtccatgac catgaacggc gccgtgatcc ccgtgctagc caacttcatc      600

gtgaccggcg aggaacaagg cgtgcccaag gagaagctca ccggcaccat ccagaacgac      660

atcctcaagg agttcatggt ccgtaatacc tacattttcc cccccgaacc cagcatgaaa      720

atcatcgccg acatcttcga gtacacggcc aaacacatgc ccaagttcaa ctccatcagc      780

atcagcggct accacatgca ggaggccggg gccgacgcca tcctggagct ggcctacacc      840

ctggccgacg ggctggagta cagcaggacc ggtctccagg ccgggctgac catcgacgag      900

tttgccccaa ggctgagctt tttctggggc atcggcatga acttttacat ggagatcgcg      960

aagatgcgcg ccgggcgtcg gctgtgggcc cacctgatcg agaagatgtt tcagcccaag     1020

aactcgaaaa gcctgcttct gcgggcccac tgtcagacca gcggctggtc cctgaccgag     1080

caggacccct acaataacat cgtgagaacc gcgatcgagg ccatggcggc cgtcttcggc     1140

gggacccaaa gcctgcacac taacagcttc gacgaggccc tgggtctccc caccgtgaag     1200

agcgccagga tcgcacgtaa cacgcagatc atcatccagg aggagagcgg gatccccaag     1260

gtggccgacc cctggggcgg gagctacatg atggagtgcc tgaccaatga cgtgtacgac     1320

gctgctctga agctgatcaa cgagatagag gagatggggg gcatggccaa ggccgtcgcc     1380

gagggcatcc ccaagctgag gatcgaggaa tgtgccgcca ggcggcaagc ccggatcgac     1440

agcggcagcg aagtgatcgt cggcgtgaat aagtaccagc tggagaaaga ggacgccgtg     1500

gaagtgctcg ccatcgacaa cacctcagtc cgtaacaggc agatagagaa actgaagaag     1560

ataaagagct cccgcgacca ggccctggcc gagcgttgcc tggccgccct gactgagtgc     1620

gccgccagcg gcgacggtaa catactagct ctggcggtgg acgccagccg ggcgaggtgc     1680

accgtcgggg aaatcaccga cgcgctgaag aaagtgttcg gagagcacaa ggccaacgat     1740

aggatggtga gcggggccta tcggcaagag ttcggagaaa gcaaggaaat caccagcgcc     1800

atcaagcgcg tgcacaagtt catggagagg gagggcagga ggccgagact gctggtggcc     1860

aagatgggcc aggacggcca cgaccgcggc gccaaggtca ttgccaccgg cttcgccgac     1920

ctcgggtttg acgtggacat cggccccctg ttccagacgc cccgggaagt ggcccagcag     1980

gccgtggacg ccgatgtgca cgccgtgggc gtgtcgaccc tggccgccgg ccacaagacc     2040

ctggtgcccg agctgatcaa ggagctgaac agcctgggta ggccagacat tctggtgatg     2100

tgcggtggag tcattccccc ccaggactac gagttcctgt tcgaggtcgg ggtgagcaac     2160

gtgttcggcc ccggaacccg catccccaaa gccgccgtgc aggtgctgga cgacatagag     2220

aagtgtctgg aaaagaaaca gcaaagcgtg                                      2250


<210>  756
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  756
atgcttaggg ccaagaacca gctgttcctc ctctcccccc actatctcag acaggtgaag       60

gagagcagcg gcagcaggct gatccaacag aggctcctcc accagcagca gcccctccac      120

ccggagtggg cagccctggc taagaaacag ctgaaaggga agaatcccga ggatctgatc      180

tggcacaccc cggaggggat atccataaag cccctgtatt cgaagaggga caccatggac      240

ctgcccgagg agctgcccgg cgtgaagccc tttacccgcg gaccctaccc caccatgtat      300

accttcaggc cctggaccat ccggcagtac gccggtttct ctaccgtgga ggagtccaac      360

aagttctaca aggacaacat caaggccggt cagcagggcc tcagcgtggc cttcgatctg      420

gccacccacc ggggctatga ttccgacaac ccgagggtcc gcggcgacgt ggggatggcc      480

ggcgtggcaa ttgataccgt ggaagacacc aagatcctgt ttgacggcat ccccctggag      540

aagatgagcg tgagcatgac catgaacggc gcagtgatcc ccgtgctggc aaatttcatc      600

gtcaccgggg aggagcaggg cgtgccaaag gagaagctga ccggcaccat ccagaatgat      660

atcctgaagg agttcatggt caggaatacc tacatcttcc cacccgagcc cagcatgaaa      720

atcatcgcgg acatcttcga gtacaccgcc aagcacatgc ccaagttcaa ttccatcagc      780

atctccgggt accacatgca ggaggccggc gccgacgcca tcctggagct cgcctacacc      840

ctggccgacg ggctggagta tagccggacg ggcctccagg ccgggctcac catagacgag      900

ttcgccccga ggctgagctt cttctggggc atcgggatga acttctatat ggaaatcgcc      960

aaaatgcgcg cggggcgccg tctttgggcc cacctgattg agaagatgtt ccagccgaag     1020

aacagcaagt ccctgctgct gcgcgcccat tgccagacct ccgggtggag cctcaccgaa     1080

caggacccct acaataacat cgtcaggacc gccatcgagg ccatggccgc cgtgttcggc     1140

gggacccagt ccctccacac caacagcttc gacgaggcac tgggtctccc cacagtgaaa     1200

agcgccagga tcgccaggaa cacccaaatc atcatccagg aagaaagcgg catcccgaag     1260

gtggccgacc cctggggcgg cagctacatg atggagtgcc tgaccaacga tgtgtacgat     1320

gccgccctga agctcatcaa cgagatcgag gagatggggg gcatggccaa agccgttgcc     1380

gaaggaatac caaagctgcg tatcgaggag tgcgccgcga ggaggcaggc gcgcatcgac     1440

agcgggtccg aggttatcgt gggcgttaac aagtatcagc tggagaagga ggacgccgtg     1500

gaggtgctgg ccatcgacaa cacctccgtg aggaacaggc agatagagaa gctgaagaaa     1560

atcaagagct ccagggacca agcgctggcc gagaggtgcc tcgccgcgct gacggagtgc     1620

gccgccagcg gcgatggcaa catcctggcc ctggccgtgg acgccagcag ggcccggtgt     1680

acagtgggcg agatcaccga cgccctcaag aaggtgtttg gggagcacaa ggcgaacgac     1740

aggatggtgt ccggcgccta ccggcaggag tttggcgagt caaaagaaat aacctccgcc     1800

atcaagcggg tgcacaagtt catggagagg gaggggagga ggcctaggct gctggtggcc     1860

aagatgggcc aggatggcca cgacaggggc gccaaagtaa tcgccacggg cttcgccgac     1920

ctcgggttcg acgtggacat aggacccctg ttccagaccc cccgggaggt ggcccagcag     1980

gccgtcgacg ccgacgtaca tgccgtcggc gtgtccaccc tggccgcagg ccacaagacc     2040

ctggtgcccg agctgatcaa ggagctcaac agcctgggca ggcccgacat tctcgtcatg     2100

tgcggcggtg tgatcccccc ccaggactac gagtttctgt tcgaggtggg cgtcagcaac     2160

gtattcgggc ccggcacgag gatccccaag gctgccgtgc aagtgctgga cgacattgag     2220

aaatgcctgg agaagaagca gcagtccgtg                                      2250


<210>  757
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  757
atgctgcgcg ccaagaacca gttgttcctc ctgagccccc actacctacg gcaggtcaaa       60

gagtccagcg gcagccggct catccagcaa aggctgctgc atcagcagca gcccctgcac      120

cccgagtggg ccgcccttgc caagaaacag ctgaagggca aaaaccccga agacctgatc      180

tggcacaccc ccgaaggcat cagcatcaag cccctgtaca gcaagcgcga caccatggac      240

ctgcccgagg aactgcccgg cgtgaaacct ttcacgaggg gcccgtaccc caccatgtat      300

accttccgcc cgtggacgat caggcagtat gctggcttca gcaccgtgga ggagagcaac      360

aagttttaca aagacaacat caaggccggg cagcaggggc tgagcgtcgc cttcgacctc      420

gccacccacc gcggctatga cagcgataat ccccgggtga ggggggacgt gggcatggcc      480

ggcgtcgcga tcgacacggt ggaggacacc aagatcctct tcgacgggat ccccctggag      540

aagatgagcg tgagcatgac tatgaacggc gccgtgatcc ccgtgctcgc caatttcatc      600

gtgacgggcg aggagcaagg cgtgccgaaa gagaagctga ccggcacgat ccagaacgat      660

atcctgaagg agtttatggt gaggaacacc tacatcttcc ccccggagcc cagcatgaag      720

atcatcgcgg acatcttcga atacaccgcg aaacacatgc ccaagtttaa tagcatcagc      780

atttccggct accacatgca ggaggccggc gccgatgcca tcctcgaact ggcctacacc      840

ctcgccgacg gtctggagta ctccaggaca gggctccagg ccggactgac catcgacgag      900

ttcgccccca ggctgagttt cttttggggc atcggcatga acttctacat ggagatcgcc      960

aaaatgaggg ccggcaggag gctgtgggcg cacctgatcg aaaagatgtt ccaaccgaag     1020

aatagcaaaa gtctgctgct ccgcgcccat tgccagacat ccggctggag cctgaccgag     1080

caggatccct acaacaacat cgtgagaacc gccatcgagg ccatggccgc cgtgttcggc     1140

ggcacccagt ccctgcacac taacagcttc gacgaagccc tgggcctccc caccgtgaaa     1200

agcgccagga tcgcccggaa cacccagatc ataatccaag aggagtctgg catcccgaag     1260

gtggcggacc cgtggggcgg ctcctatatg atggagtgcc tgaccaacga cgtgtacgac     1320

gccgccctga aactcatcaa cgagatagaa gaaatgggcg gcatggcgaa ggccgtcgcc     1380

gagggcatcc ccaagctgag gatcgaagag tgcgccgcca ggaggcaggc caggatcgat     1440

agcggctccg aggtgatcgt gggcgtgaat aagtaccaac tggagaagga ggacgccgtg     1500

gaggtgctgg ccattgacaa cacctccgtc aggaacaggc agatcgagaa actgaagaag     1560

atcaagagct cacgggacca ggcgctggcc gaacgatgcc tggccgccct gaccgaatgc     1620

gcggccagcg gggacggcaa catcctggcc ctggccgtgg atgcgtccag ggcgaggtgt     1680

accgtgggcg agatcaccga cgccctcaag aaggtgttcg gcgagcacaa ggccaacgac     1740

cggatggtct ccggcgccta caggcaagag ttcggggagt ccaaggagat taccagcgcc     1800

atcaagaggg tccacaagtt catggagagg gagggcaggc gcccccggct cctagtggcc     1860

aagatgggcc aggacggcca cgacaggggg gccaaggtga tcgcgacggg atttgccgat     1920

ctgggcttcg acgtggacat cggccccctg ttccagacgc ccagggaggt ggcccaacag     1980

gccgtggacg ccgacgtgca cgccgtgggc gtctccactc tggctgccgg ccataagacc     2040

ctggtgcccg aactcattaa ggaactgaat agcctcgggc gtcccgacat actggtgatg     2100

tgcggcgggg tgatcccccc acaggactac gaattcctgt tcgaggtggg ggtctccaac     2160

gtgttcggcc ccggtacccg gatccccaag gcagccgtgc aggtactcga cgacatcgag     2220

aagtgtctgg agaagaagca gcagagcgta                                      2250


<210>  758
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  758
atgctaagag cgaagaatca gctgttcctc ctgagccccc attacctgag acaggtgaag       60

gaatccagcg gctcccgcct gatacagcag aggctgctcc accagcagca gcccctgcac      120

cccgagtggg ccgccctggc caaaaagcag ctcaagggca aaaaccccga agacctgatc      180

tggcacaccc cagaggggat ctccatcaaa ccgctgtaca gcaagaggga caccatggac      240

ctgcccgagg aactgcccgg ggtgaagccg ttcaccaggg gcccctaccc caccatgtat      300

acgttcaggc cctggaccat caggcagtac gccggattca gcacggtgga ggaaagcaac      360

aagttctaca aggataacat aaaggccggg cagcagggcc tgagcgtggc cttcgacctg      420

gccacccacc gaggctacga cagcgataac cccagggtgc ggggcgatgt cggaatggcc      480

ggcgtggcca tcgacacggt cgaggacacc aagatcctct tcgacgggat ccccctcgag      540

aaaatgtccg tgtccatgac catgaacggc gccgtgatcc ccgtgctggc caatttcatc      600

gtgaccgggg aggagcaggg cgtgcccaag gagaagctga ccggcaccat ccagaacgac      660

atcttgaagg aattcatggt gcgaaacacc tacatcttcc cccccgagcc aagcatgaag      720

atcatcgcgg acatcttcga atacaccgcc aagcacatgc ccaaatttaa tagcatctcc      780

atctccggct atcacatgca ggaggccggt gccgacgcga tcctggagct ggcctatacc      840

ctcgccgacg gtctggagta cagccggacc ggcctccagg ccggcctcac catcgacgaa      900

ttcgccccgc ggctgagctt cttctggggc atcggcatga acttctacat ggagatcgcc      960

aagatgaggg ccggccgcag gctgtgggct catctcatcg agaagatgtt ccagcccaag     1020

aactcgaaga gcctgctcct gagggcccat tgccagacca gcgggtggtc cctgaccgag     1080

caggatccct ataacaatat cgtgcgtacc gccatcgaag ccatggcagc cgtgttcggc     1140

ggcacccaga gcctccacac caacagcttc gacgaagccc tgggcctgcc cactgtgaag     1200

tccgccagga tcgcccggaa cacccagatc atcatccaag aggagagcgg gatccccaag     1260

gtggccgacc cctggggggg cagctacatg atggagtgcc tgaccaacga cgtgtatgac     1320

gccgccctca agctcatcaa cgagatcgaa gagatgggcg gcatggctaa ggccgttgcc     1380

gagggcatcc ccaagctgag gatcgaggag tgcgcagccc ggaggcaggc caggatcgat     1440

agcggctcgg aagtgatcgt gggggtgaac aagtaccagc ttgagaagga ggacgccgtg     1500

gaggtgctgg ccatcgacaa tacctccgtg agaaacaggc agatcgaaaa gctgaagaaa     1560

atcaagagct ccagggacca ggcgctcgcg gagcgatgcc tcgccgccct gaccgagtgt     1620

gccgcctcgg gtgacgggaa catcctggcc ctcgccgtcg acgcctccag ggcccggtgc     1680

accgtgggcg agatcaccga cgccctgaag aaggtgttcg gcgagcataa agccaacgac     1740

aggatggtga gcggcgccta caggcaggag tttggcgaga gcaaggagat caccagcgct     1800

atcaagaggg tgcacaagtt catggaaagg gaggggagga ggccccgcct gctggtcgcc     1860

aagatgggcc aagacgggca cgataggggc gccaaggtga tcgcgaccgg cttcgccgac     1920

ctgggatttg acgtggacat cgggccactg ttccagacgc cccgggaggt cgcccagcag     1980

gccgtcgacg ccgacgtgca cgcggtgggc gtgagcacac tggcagccgg ccacaaaacc     2040

ctggtgccgg agctgatcaa agagctgaac agcctgggaa ggcccgacat cctggtcatg     2100

tgcggcggag ttatcccccc ccaggactac gaattcctgt tcgaggtggg cgtcagcaac     2160

gtgttcgggc ccggtaccag gatccccaag gccgccgtcc aggtgctgga cgacatcgag     2220

aaatgcctgg aaaagaaaca acaaagcgtg                                      2250


<210>  759
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  759
atgctgcgcg ccaagaatca gctgttcctg ctgagccccc actacctgcg ccaggtgaag       60

gaatcgagcg gatcgaggct gatccagcag aggctgcttc accagcagca accccttcac      120

cccgagtggg ccgcactggc gaagaagcaa ctgaagggta agaaccccga agacttaatc      180

tggcacaccc ccgaagggat cagcatcaag cccctgtaca gcaaaaggga caccatggac      240

ctgccggagg agctgcccgg ggtgaagccc ttcaccaggg gcccctaccc cacgatgtac      300

accttccggc cctggactat ccgtcagtac gccggctttt ccacagtgga ggagagcaac      360

aagttttata aggacaacat caaggccggc cagcaaggcc tgagcgtggc gtttgacctg      420

gccacccaca ggggctacga ctccgacaac ccacgggtga ggggcgacgt cggcatggcc      480

ggggtggcca tcgacaccgt ggaggacacc aagatcctgt tcgacggcat ccccctcgag      540

aaaatgagcg tgtccatgac catgaacggc gccgtgattc cggtgctggc caacttcatt      600

gtcaccggag aggagcaagg cgtgccaaag gagaagctga ccgggaccat ccagaacgac      660

attctgaaag agttcatggt gcgcaacacg tacatattcc cccccgagcc cagcatgaag      720

atcatcgctg acatcttcga gtacaccgcc aagcatatgc ccaagttcaa cagcatcagc      780

atctccggct accacatgca agaagccggc gccgatgcca tactcgagct cgcctacacc      840

ctggccgatg gtctggaata ctccaggacg ggcctgcagg cgggcctcac catcgacgag      900

tttgcgccca ggctgagctt cttttggggc atcggcatga acttctacat ggaaatcgcc      960

aagatgaggg ccggcaggcg cctgtgggcg cacctcatcg agaagatgtt ccagccgaag     1020

aactccaaaa gcctgctgct gcgggcccat tgtcagacct ccggctggtc cctcacggag     1080

caggatccct acaataacat cgtgcgcacc gccatcgagg caatggccgc cgttttcggg     1140

ggcacgcaga gcctgcacac aaacagcttc gacgaggcgc tgggcctgcc caccgtcaag     1200

tccgccagga tcgcccgaaa cacccagatc atcatccagg aggagagcgg gatcccgaaa     1260

gtggcggacc cctggggcgg cagctatatg atggagtgcc tgaccaacga cgtctacgac     1320

gccgccctga agctgatcaa cgagatcgag gaaatgggcg ggatggcgaa ggccgtcgcc     1380

gagggcatcc ccaagctgcg cattgaggag tgcgccgcga ggcgccaggc ccggatcgat     1440

agcggctccg aggtgatcgt cggggtcaac aaataccaac tggagaagga ggacgccgta     1500

gaagtgctcg cgatcgacaa caccagcgtg aggaaccgcc agatcgaaaa gctcaagaag     1560

atcaagagca gccgggatca agccctggcc gagagatgcc tggccgcgct cactgagtgc     1620

gccgccagcg gggacggcaa catcctggcg ctggccgtgg atgccagccg cgccaggtgc     1680

accgtcggcg agatcacgga cgccctgaag aaggtcttcg gagagcacaa ggccaacgac     1740

cggatggtca gcggcgcgta caggcaggag ttcggcgagt ctaaggagat cacctccgcc     1800

atcaaaaggg tgcacaaatt catggaacgg gagggcagga ggccgaggct gctggtggcc     1860

aagatgggcc aggacgggca cgatcgcggc gccaaggtca tcgccacggg cttcgccgac     1920

ctgggtttcg acgtggacat cggcccactg ttccagaccc cccgggaggt ggcccagcag     1980

gccgtggatg ccgacgtgca cgccgtgggc gtgagcaccc tggccgccgg acacaagacc     2040

ctcgtgcccg agctcataaa ggagctgaac agcctgggca ggcccgacat actggtgatg     2100

tgcgggggcg tgatcccccc tcaagactat gagtttctgt ttgaggtcgg ggtgtccaac     2160

gtgttcggac cgggcacccg catcccgaag gccgccgtgc aggtgctgga cgacatcgag     2220

aagtgcctgg agaaaaaaca acagagcgtg                                      2250


<210>  760
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  760
atgcttcggg cgaagaacca gctgttcctg ctgtccccgc actacctcag gcaggtgaag       60

gagagctccg gcagccgcct gatccagcag aggctgctgc accagcagca gcccctgcac      120

ccggagtggg ccgcgctggc caagaagcag ctgaagggca agaaccccga ggacctgata      180

tggcacaccc ccgagggcat ctccatcaag ccgctgtatt cgaagaggga caccatggac      240

ctgcctgagg agctgcctgg ggtaaagccc ttcaccaggg ggccctaccc caccatgtac      300

acctttcggc catggaccat ccggcaatat gccgggttct caaccgtgga ggagagcaac      360

aagttctaca aggacaacat taaggcgggg cagcaggggc tgtccgtggc gttcgacctg      420

gccacccacc ggggctatga cagcgacaat ccccgggtga ggggggacgt gggcatggcg      480

ggcgtggcca tcgatacagt cgaggacacg aagatactgt ttgacggcat ccccctggag      540

aaaatgtcgg tgtcgatgac gatgaacggc gccgtgatcc cggtgctggc caacttcatc      600

gtgaccggcg aggagcaggg ggtgcctaag gagaaactga ccgggaccat ccagaacgac      660

atcctgaagg agttcatggt gcgcaacacc tacatatttc cccccgagcc cagcatgaag      720

atcatcgccg acatcttcga atacaccgcc aagcatatgc ccaagttcaa cagcatcagc      780

atctccgggt accacatgca ggaggccggc gccgacgcca tcctggaact ggcctacacc      840

ctggccgacg gcctggagta cagcagaacc gggctccagg caggcctgac catcgacgag      900

ttcgccccac ggctgtcctt cttctggggg atcggcatga acttctatat ggagatcgcc      960

aagatgaggg ccgggcggag gctctgggcc catctgatcg agaagatgtt ccagccaaag     1020

aacagcaaga gcctcctgct gagggcccac tgccagacca gcggctggtc cctgaccgag     1080

caggacccct acaacaacat cgtcaggacg gccatcgagg cgatggccgc cgtgtttgga     1140

ggcacccaga gcctgcatac caacagcttc gacgaggccc tgggcctgcc cactgtgaag     1200

agcgccagga tcgccaggaa cacccagatc atcatccagg aggagagcgg catccccaag     1260

gtggcggacc cttggggtgg ctcctacatg atggaatgcc tcacaaatga tgtgtacgac     1320

gccgccctca aactgatcaa cgaaatcgag gagatgggtg gcatggccaa agccgtagcg     1380

gagggcatcc ccaagctccg gatcgaggag tgcgccgcca ggcgacaggc ccggatcgac     1440

agcggctccg aggtcatcgt cggggtgaac aagtaccagc tcgaaaagga ggacgccgtg     1500

gaggtgctgg cgatcgacaa caccagcgtg cggaacaggc agatagagaa gctgaagaag     1560

atcaagagca gtagggacca ggccctcgcc gagaggtgtc tggccgccct gaccgagtgc     1620

gccgcctccg gcgatggcaa catcctggcc cttgccgtgg acgcgagccg cgccaggtgc     1680

accgtgggcg agatcaccga cgccctgaag aaggtgtttg gcgaacacaa ggccaacgac     1740

aggatggtgt ccggcgccta ccgtcaggag ttcggcgaga gcaaggagat caccagcgcc     1800

atcaagaggg tgcacaagtt tatggaacgc gaagggaggc gccccaggct gctggtggcc     1860

aagatggggc aggacgggca cgacaggggc gccaaagtca tcgccaccgg ctttgccgac     1920

ctgggattcg atgtggacat cggccccctg tttcagaccc ccagagaggt cgcccaacag     1980

gcggtcgacg ccgacgtcca tgccgtcggc gtgagcaccc tggccgccgg gcacaagacg     2040

ctcgtgcccg agctgatcaa ggagctgaac agcctgggca ggcccgacat cttagtgatg     2100

tgcggggggg tgattccccc ccaggactat gagttccttt tcgaagtggg tgtcagcaac     2160

gtgttcggcc cgggcacccg catccccaag gctgcggtcc aggtgctgga cgacatcgag     2220

aagtgcctgg agaagaaaca gcaatccgtg                                      2250


<210>  761
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  761
atgctgaggg ccaagaacca gctgtttctc ctgtcgcccc actacctgag gcaggtgaag       60

gagtcctccg gcagcaggct cattcagcag aggctgttgc accagcagca gcccctgcac      120

ccagagtggg ccgccctcgc caagaagcag ctgaagggga agaaccccga ggacctgatc      180

tggcatacgc ccgagggtat ctccataaaa cccctctaca gtaagaggga caccatggac      240

ctgcccgagg aactgcccgg cgtgaagccg ttcacgcggg gcccataccc caccatgtac      300

accttccggc cgtggaccat caggcaatac gccggcttca gcaccgtgga ggagagcaac      360

aagttctaca aagacaacat caaagccggt cagcaagggc tgagcgtagc cttcgacctg      420

gccacccaca ggggctacga ctccgacaac cccagggtgc gcggcgacgt gggcatggcc      480

ggcgtggcca tcgacaccgt ggaagacacc aagatcctct tcgacggcat ccccctggaa      540

aagatgtccg tgtccatgac catgaacggg gccgttatac cggtgctggc caacttcata      600

gtcaccggcg aggagcaggg ggtcccgaag gagaagttaa ccggcacgat tcagaacgac      660

atcctgaaag agttcatggt gaggaacacc tatatcttcc cccccgagcc ctccatgaaa      720

atcatcgccg acatcttcga gtacaccgcg aagcacatgc ccaagttcaa ctccatcagc      780

atctccggat atcacatgca ggaagccggc gccgacgcca tcctggagct ggcctacacc      840

ctggcggacg gactggagta cagccgcacg ggcctgcagg cgggcctgac catagacgaa      900

tttgccccgc ggctgagctt tttctggggg atcggcatga atttctacat ggagatcgcc      960

aagatgcggg ccggcagacg gctgtgggcc catctgatcg aaaaaatgtt ccagcccaaa     1020

aacagcaagt ccctgctgct gcgggcccac tgccagacca gcggctggag cctgaccgag     1080

caggacccgt acaataacat cgtgaggacc gccatcgagg ccatggccgc cgtgttcggc     1140

gggacgcaaa gcctgcacac gaactccttc gacgaggcgc tcggcctgcc caccgtgaag     1200

tccgctagga tcgccaggaa cacacagatc atcatccagg aggagagcgg catccccaag     1260

gtggccgacc cctggggcgg ctcctacatg atggagtgcc tgacgaacga cgtgtacgac     1320

gccgccctga agctgatcaa cgagatcgag gagatgggcg gcatggccaa ggccgtcgcc     1380

gagggcatcc ccaagctgcg catcgaggag tgcgccgcca ggcgccaagc ccggatcgat     1440

agcggcagcg aggtgatcgt gggggtgaac aagtaccagc tggagaagga ggacgcggtc     1500

gaggtcctgg ccatagacaa cacgagcgtg cggaacaggc agatcgagaa gctcaagaaa     1560

atcaagagca gccgggacca ggccctggcc gaaaggtgcc tcgccgccct cacggaatgc     1620

gccgccagcg gcgacggcaa tatcctggcc ctggcggtcg atgccagccg cgctcggtgc     1680

accgtggggg agatcaccga tgccctcaag aaagtgttcg gggagcacaa ggccaacgac     1740

aggatggtgt ccggcgccta caggcaggag ttcggcgaaa gcaaggaaat cacgagcgcc     1800

atcaagcggg tccataagtt catggagagg gagggccgga ggcccaggct gctcgtggcc     1860

aaaatgggcc aggacggcca tgacaggggc gccaaggtga tcgccaccgg gttcgccgac     1920

ctcggcttcg acgtggacat cgggccgctg ttccagacgc cgcgggaggt cgcccagcaa     1980

gcggtggacg ccgacgtgca cgccgtcggg gtgagcaccc tcgccgctgg gcataagacc     2040

ctggtgcccg agctgatcaa agagctcaac agcctcggca ggcccgacat tctcgttatg     2100

tgcggcggcg tcatcccgcc ccaggactac gagttcctgt ttgaggtcgg cgtctccaac     2160

gtgttcggcc caggcaccag gatccccaag gccgccgtgc aggtgttgga cgatatcgag     2220

aaatgcctcg agaaaaagca gcagagcgtc                                      2250


<210>  762
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  762
atgctgaggg cgaagaatca gctgtttctg ctgagccccc actacctcag gcaggtgaag       60

gagagcagcg gcagcaggct gatccagcag aggctgctgc accagcagca acccctgcac      120

cccgagtggg cggccctggc caagaagcag ctcaagggca agaaccctga agacctgatc      180

tggcacaccc ccgagggaat cagcatcaag ccgctgtact ccaagaggga caccatggac      240

ctgcccgagg agctccccgg cgtcaagccc ttcacccggg gcccctaccc caccatgtac      300

accttcaggc cctggaccat ccgccagtac gcgggcttct ccaccgtgga agagtccaac      360

aagttctaca aggacaacat caaggccggg caacagggcc tctccgtggc cttcgacctg      420

gccacgcacc ggggttacga ttctgacaac ccgcgcgtgc ggggcgacgt cgggatggcc      480

ggggtcgcga tcgacaccgt cgaggatacc aagatcctgt tcgacggcat ccccctcgag      540

aagatgagcg tcagcatgac catgaacggc gccgtgatcc ccgtgctggc caacttcatc      600

gtcaccggcg aggagcaggg ggtccccaaa gagaagctaa ccggcaccat ccagaacgac      660

atcctgaagg agttcatggt gaggaacacc tatatcttcc cgcccgagcc cagcatgaag      720

atcatcgccg acatcttcga gtacaccgcc aagcacatgc ccaagttcaa cagcataagc      780

atcagcgggt accacatgca ggaggccggt gcggacgcca tcctcgagct cgcctatacc      840

ctggcagacg gtctggagta cagcaggacc ggactgcaag ccgggctgac gatcgacgaa      900

ttcgccccca ggctgagctt cttctggggt attggcatga acttctacat ggagatcgcc      960

aagatgaggg ccggcaggcg gctctgggcc cacctcatcg agaagatgtt ccagcccaag     1020

aacagcaagt ccctgctgct cagggcccac tgccagacaa gcgggtggag cctcaccgag     1080

caggacccgt acaacaacat cgtgcgcacc gccatcgaag ccatggcggc cgtcttcggc     1140

ggcacccaga gcctgcatac caacagcttc gacgaggctc tgggcctgcc cacggtgaag     1200

tccgccagga tcgcccggaa cacccagatt ataatccagg aagagagcgg cattcccaag     1260

gtggcggacc catggggtgg cagctacatg atggaatgcc tcaccaatga cgtgtacgac     1320

gcggccctga agctgatcaa cgagatcgag gagatggggg ggatggccaa ggccgtggcc     1380

gagggcatcc ccaagctgag gatcgaagag tgcgccgccc gaaggcaggc ccggatcgac     1440

agcggcagcg aagtcatcgt gggcgtgaac aagtaccaac tcgagaagga ggacgcagtc     1500

gaagtgctcg ccatcgacaa caccagcgtg aggaaccggc agatcgagaa gctgaagaag     1560

atcaagtcct ccagagacca ggccctggcc gagaggtgcc tggccgccct gacggaatgc     1620

gccgccagcg gcgacggaaa catcctggcc ctggccgtag acgccagcag ggccaggtgt     1680

accgtgggcg agatcacgga cgcgctgaaa aaggtctttg gcgagcacaa agccaacgac     1740

aggatggtga gcggcgccta tcgccaggag ttcggcgagt ccaaggaaat caccagcgcc     1800

atcaagcggg tccacaagtt catggagagg gagggacgcc gcccccggct gctggtggcc     1860

aagatgggcc aggacgggca tgacaggggg gccaaggtga tcgccacggg ctttgccgat     1920

ctgggcttcg atgtggacat cggccccctg tttcagacgc ccagagaggt ggcccaacag     1980

gccgtggacg ccgacgtgca cgccgtgggt gtctccaccc tggccgccgg ccacaagacg     2040

ctcgtgcccg agctgatcaa ggagctgaac tccctgggcc gccccgatat cctggtgatg     2100

tgcggggggg tgatcccccc ccaggactac gagttcctgt ttgaggtggg cgtgtccaac     2160

gtgttcgggc ccggcaccag gatccccaag gccgccgtgc aggtgctgga cgacatcgag     2220

aagtgtctgg aaaaaaagca acagagcgtg                                      2250


<210>  763
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  763
atgctgaggg ccaagaacca gctgtttctg ctgagccccc actacctgcg gcaggtgaag       60

gaaagctccg gcagccggct gattcagcag cgcctgctgc accagcagca gcccctgcat      120

cccgagtggg ccgccctggc caagaagcag ctgaagggca agaaccccga ggacctgatc      180

tggcataccc ccgaagggat ctccatcaag cccctgtact ccaagaggga tacgatggac      240

ttgcccgaag agctccccgg cgtgaaaccc ttcacccggg gcccttaccc gactatgtac      300

accttcaggc cctggaccat caggcagtac gccggcttct ccaccgtgga ggagagcaac      360

aagttctaca aggataatat caaggccggc cagcagggcc tcagcgtggc cttcgacctg      420

gccacccacc gtggctacga cagcgacaac ccccgcgtcc ggggcgatgt gggaatggcc      480

ggcgtggcca tcgataccgt ggaggatacg aagatactat tcgacggtat ccccctggag      540

aagatgagcg tgagcatgac catgaacggc gcggtgatac ccgtgctggc caacttcatc      600

gtcacggggg aggagcaagg cgtgcccaaa gaaaagctga ccggcaccat ccagaacgac      660

atcctcaagg aattcatggt gcggaacacc tacatcttcc cccccgagcc ctccatgaag      720

attatcgccg atatcttcga gtacaccgcc aagcacatgc ccaagttcaa tagcatctcc      780

atctccggct accacatgca agaggccggc gccgacgcaa tcctggagct ggcctacaca      840

ctcgccgatg gcctggagta ttccaggacc ggcctgcagg ccggcctgac catcgacgag      900

ttcgccccca ggctgagctt cttttggggc attggcatga atttctacat ggagatcgcg      960

aagatgaggg ccggccggcg gctgtgggca cacctgatcg aaaagatgtt ccaacccaag     1020

aacagtaaga gcctgctgct gagggcccac tgccagacca gcggctggag cctgaccgag     1080

caggacccct acaataacat tgtgcggacc gccatcgagg cgatggccgc cgtgttcggc     1140

ggcacacaga gcctgcacac caacagcttt gatgaggccc tcggcctgcc cacggtgaag     1200

tccgccagga tcgccaggaa cactcagatc atcatccagg aggaaagcgg catccccaaa     1260

gtggccgacc cctggggcgg cagctacatg atggagtgcc tgaccaacga cgtctacgat     1320

gccgccctga aactcatcaa cgagattgag gagatgggcg gcatggccaa ggccgtggcc     1380

gaggggatcc ccaaactgag gatcgaagag tgcgccgccc ggaggcaggc ccgtatcgac     1440

tccggctccg aggtcatcgt gggggtgaat aaataccagc tggaaaagga ggacgccgtg     1500

gaggtcctcg ccatcgacaa cacctcggtc cgcaaccggc agatcgagaa gctcaaaaag     1560

atcaagtcct cgagggatca ggccctcgcc gagaggtgcc tggccgccct gacggagtgc     1620

gcggccagcg gggatggcaa catcctcgcc ctggcggtgg acgcctcccg cgccagatgt     1680

actgtcggcg agatcaccga cgccctcaag aaagtgttcg gcgagcacaa ggccaacgac     1740

aggatggtgt ccggcgccta tcgtcaggag tttggcgagt ccaaggaaat caccagcgcc     1800

atcaagaggg tgcacaagtt catggagagg gaggggcggc gaccccgcct gctggtggcc     1860

aagatgggtc aggacgggca cgataggggc gccaaggtga ttgccaccgg attcgccgac     1920

ctgggcttcg acgtggacat cggccccctg ttccagacac ccagggaagt ggcccagcag     1980

gccgtggacg cggacgtgca cgccgtgggc gtgtcgaccc tcgccgccgg tcataagacc     2040

ctcgtgcccg agctgatcaa ggagctgaac agcctgggca ggcccgatat cctggtgatg     2100

tgtgggggcg taatcccccc gcaggattac gagttcctgt tcgaagtggg ggtgtccaac     2160

gtgttcgggc ccggcacccg gattcccaag gcggccgtgc aggtgctgga cgacatcgag     2220

aagtgtctgg aaaagaagca acagagcgtg                                      2250


<210>  764
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  764
atgctgaggg caaaaaacca gctcttcctg ctcagccccc actacctcag gcaagtgaag       60

gagtcctccg gctcccgtct gattcagcag aggctgctgc accagcagca gcccctgcac      120

cccgagtggg ccgccctcgc gaagaaacag ctcaagggga agaacccgga ggacctcatc      180

tggcacaccc ccgagggaat cagcatcaag cccctctact ccaagaggga taccatggac      240

ctgcccgagg agctgcccgg cgtgaaaccc ttcacccgtg gcccctaccc cacgatgtac      300

accttcaggc cctggaccat ccgccagtac gccggcttct ccaccgtgga ggagtccaac      360

aaattctaca aagacaatat caaggccgga caacagggcc tctccgtggc attcgatctg      420

gctacacaca gggggtacga ctccgacaac cccagggtgc ggggcgacgt cggtatggcc      480

ggggtcgcca tcgacacggt ggaagacacc aagatcctgt ttgacggcat ccccctggag      540

aaaatgagcg tgtccatgac catgaacggc gccgtgatcc ccgtcctggc caacttcatc      600

gtgaccggcg aagagcaggg cgtgcccaaa gagaagctga ccggtaccat ccaaaacgac      660

atcctgaaag agtttatggt ccggaacacc tacatcttcc cccccgagcc cagcatgaaa      720

atcattgcag atatattcga gtacaccgcc aaacatatgc ccaagttcaa cagcatctcc      780

atatccgggt atcacatgca ggaggccggg gccgacgcca tcctggagct ggcctacacc      840

ctggccgacg gcctggagta ttcccgaacg ggcctccagg ccgggctgac aatcgacgag      900

ttcgccccca ggttgagctt cttctggggc ataggaatga acttctacat ggaaatagcc      960

aagatgaggg ccggcaggag actgtgggcc cacctgatcg agaagatgtt ccagcccaag     1020

aacagcaaga gcctgctgct gcgggcccac tgccagacca gtggctggtc cctgaccgag     1080

caggacccct acaataacat cgtcaggacc gccatcgagg ccatggcggc cgtgttcgga     1140

ggcacgcaga gcctccacac caacagcttc gacgaggccc tgggcctgcc cacggtgaag     1200

agcgcccgga tcgcccgcaa cacccagatc atcatccagg aggagagcgg catccccaag     1260

gtggccgacc cctggggcgg tagctacatg atggagtgcc tgaccaacga cgtctacgat     1320

gcggccctca agctgatcaa cgagatcgag gagatgggcg ggatggccaa agccgtcgcc     1380

gagggaatcc cgaagctgag gatagaggag tgcgccgcga ggcgccaggc caggatcgat     1440

tccggctccg aggtgatcgt gggcgtgaac aagtaccagc tcgagaagga ggacgccgtg     1500

gaggtgctgg ccatagacaa cacctccgtg cggaaccgcc agatcgagaa actgaagaag     1560

atcaagtcca gccgcgacca ggccctggcc gagcggtgtc tggccgcgct cactgagtgc     1620

gccgccagcg gcgacggaaa catactggcc ctggccgtgg acgcctcccg cgccaggtgc     1680

acggtgggag agatcaccga cgccctgaag aaggtgttcg gggaacacaa ggccaacgat     1740

cggatggtct ccggcgccta ccgacaggag ttcggcgaaa gcaaggagat taccagcgcc     1800

atcaagcggg tgcacaagtt tatggagagg gagggccgga ggccccggct gctcgtggcc     1860

aagatgggcc aggatggaca cgatcgaggg gccaaagtca tcgccaccgg gttcgccgac     1920

ctcggcttcg acgtggacat cgggccgctg ttccagaccc ccagggaggt cgcccagcag     1980

gccgtggatg ccgacgtgca cgccgtcggc gtttccaccc tggccgccgg ccataagacc     2040

ctggtgcccg agctgatcaa ggagctgaac tcactcggcc ggcccgacat cctcgtgatg     2100

tgcgggggcg tcataccccc gcaggactac gagtttctgt tcgaggtggg ggtttccaac     2160

gtgttcggcc cgggcacccg gatccccaaa gccgccgtgc aggtgctcga tgacattgaa     2220

aagtgtctgg agaagaaaca gcaatccgtg                                      2250


<210>  765
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  765
atgctgaggg ccaagaacca gctgttcctg ctgtctcccc actatctaag gcaggtcaag       60

gagagcagcg gcagcaggct gatccagcag cgtcttctgc accagcagca gccactgcat      120

cccgagtggg ccgccctggc caagaagcag ctgaagggca agaaccccga ggacctgatc      180

tggcacaccc ctgagggcat cagcatcaag cccctgtact caaaacgcga caccatggac      240

ctgcccgaag agctgcccgg ggtgaagccc ttcacccggg gcccataccc cacgatgtac      300

acctttaggc cgtggaccat caggcagtat gccggcttct caaccgtgga ggagagcaac      360

aagttttaca aagacaacat caaggccggc cagcagggcc tgtccgtggc cttcgacctg      420

gccacacacc gggggtacga cagcgacaac ccccgcgtgc gtggtgatgt cgggatggcc      480

ggagtggcca tagacacggt ggaggacacc aagatcctgt tcgacggcat ccccctggaa      540

aagatgagcg tgagcatgac catgaacggc gccgtcatcc ccgtgctggc aaacttcatc      600

gtgaccggcg aggagcaggg cgtgccgaag gagaagctga ccggcaccat ccagaacgac      660

atcctgaagg aatttatggt caggaatacc tacatcttcc cacccgagcc ctccatgaag      720

atcatcgccg acatcttcga atacaccgcc aagcatatgc ccaaattcaa tagcatcagc      780

atcagcggtt accacatgca ggaagccggc gcggacgcca tcctggagct ggcctacacc      840

ctggcagatg gcctggagta ctcccgaacg ggactgcagg ccgggctgac catcgacgag      900

ttcgccccca ggctgagctt cttttggggc atcggcatga acttctacat ggaaatcgcc      960

aaaatgcgtg cgggcaggag gctgtgggcc catctgatcg agaagatgtt ccagcccaag     1020

aacagcaagt ccctcctgct cagggcccac tgtcaaacca gcgggtggtc gctgaccgag     1080

caggacccct acaacaacat cgtccggacc gccattgagg cgatggccgc cgtgtttggg     1140

ggcacccagt ccctgcacac caacagcttc gacgaggccc tggggctgcc aaccgtcaag     1200

agcgcccgga tcgcgaggaa cacccagatc ataatccagg aggagtccgg catccccaag     1260

gtcgccgacc catggggcgg ctcctacatg atggagtgcc tcaccaacga cgtgtacgac     1320

gccgccctga agctgatcaa cgaaatcgag gagatgggcg gaatggccaa agccgtggcc     1380

gagggcatcc cgaagctgag gattgaggag tgcgccgcca ggcggcaggc ccggatcgac     1440

agcggcagcg aggtgatcgt gggcgtgaac aagtatcagc tggagaaaga ggacgcggtg     1500

gaggtcctgg ccatcgacaa tacctcggtg aggaaccgcc agatcgagaa gctgaaaaag     1560

atcaagtcct ccagggacca ggccctggcc gagcgatgcc tcgccgccct gaccgagtgc     1620

gccgcctccg gcgacgggaa catcctggcc ctggcggtgg acgccagccg ggccaggtgt     1680

accgtgggcg agatcaccga cgccctgaag aaggtgttcg gcgagcataa ggccaacgat     1740

cgcatggtca gcggcgccta caggcaggag ttcggagaga gcaaggagat taccagcgcc     1800

atcaagaggg tgcacaagtt catggaacgg gaggggaggc ggcccaggct gcttgtggcg     1860

aagatgggcc aggatggcca cgacaggggc gccaaggtga tcgccaccgg cttcgccgac     1920

ctggggttcg atgtggacat cggacccctg tttcagaccc ccagggaggt ggcccaacag     1980

gctgtggacg ccgacgtgca cgccgtcggc gtctccaccc tggccgccgg acacaagacc     2040

ctggtgcccg agctgatcaa agagctgaac agcctgggga ggccggatat cctggtgatg     2100

tgcggcgggg tcatcccccc ccaagactac gagttcctgt tcgaagtggg agtcagcaac     2160

gtcttcgggc ccggcacccg gatcccgaag gccgccgtcc aggtgctgga cgacatcgag     2220

aagtgcctgg agaagaaaca gcagagcgtg                                      2250


<210>  766
<211>  2506
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mRNAs encoding human MCM

<400>  766
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatgctgcg ggccaagaac cagctgttcc      120

tgctgagccc ccactacctg cggcaggtga aggagagcag cggcagccgg ctgatccagc      180

agcggctgct gcaccagcag cagcccctgc accccgagtg ggccgccctg gccaagaagc      240

agctgaaggg caagaacccc gaggacctga tctggcacac ccccgagggc atcagcatca      300

agcccctgta cagcaagcgg gacaccatgg acctgcccga ggagctgccc ggcgtgaagc      360

ccttcacccg gggcccctac cccaccatgt acaccttccg gccctggacc atccggcagt      420

acgccggctt cagcaccgtg gaggagagca acaagttcta caaggacaac atcaaggccg      480

gccagcaggg cctgagcgtg gccttcgacc tggccaccca ccggggctac gacagcgaca      540

acccccgggt gcggggcgac gtgggcatgg ccggcgtggc catcgacacc gtggaggaca      600

ccaagatcct gttcgacggc atccccctgg agaagatgag cgtgagcatg accatgaacg      660

gcgccgtgat ccccgtgctg gccaacttca tcgtgaccgg cgaggagcag ggcgtgccca      720

aggagaagct gaccggcacc atccagaacg acatcctgaa ggagttcatg gtgcggaaca      780

cctacatctt cccccccgag cccagcatga agatcatcgc cgacatcttc gagtacaccg      840

ccaagcacat gcccaagttc aacagcatca gcatcagcgg ctaccacatg caggaggccg      900

gcgccgacgc catcctggag ctggcctaca ccctggccga cggcctggag tacagccgga      960

ccggcctgca ggccggcctg accatcgacg agttcgcccc ccggctgagc ttcttctggg     1020

gcatcggcat gaacttctac atggagatcg ccaagatgcg ggccggccgg cggctgtggg     1080

cccacctgat cgagaagatg ttccagccca agaacagcaa gagcctgctg ctgcgggccc     1140

actgccagac cagcggctgg agcctgaccg agcaggaccc ctacaacaac atcgtgcgga     1200

ccgccatcga ggccatggcc gccgtgttcg gcggcaccca gagcctgcac accaacagct     1260

tcgacgaggc cctgggcctg cccaccgtga agagcgcccg gatcgcccgg aacacccaga     1320

tcatcatcca ggaggagagc ggcatcccca aggtggccga cccctggggc ggcagctaca     1380

tgatggagtg cctgaccaac gacgtgtacg acgccgccct gaagctgatc aacgagatcg     1440

aggagatggg cggcatggcc aaggccgtgg ccgagggcat ccccaagctg cggatcgagg     1500

agtgcgccgc ccggcggcag gcccggatcg acagcggcag cgaggtgatc gtgggcgtga     1560

acaagtacca gctggagaag gaggacgccg tggaggtgct ggccatcgac aacaccagcg     1620

tgcggaaccg gcagatcgag aagctgaaga agatcaagag cagccgggac caggccctgg     1680

ccgagcggtg cctggccgcc ctgaccgagt gcgccgccag cggcgacggc aacatcctgg     1740

ccctggccgt ggacgccagc cgggcccggt gcaccgtggg cgagatcacc gacgccctga     1800

agaaggtgtt cggcgagcac aaggccaacg accggatggt gagcggcgcc taccggcagg     1860

agttcggcga gagcaaggag atcaccagcg ccatcaagcg ggtgcacaag ttcatggagc     1920

gggagggccg gcggccccgg ctgctggtgg ccaagatggg ccaggacggc cacgaccggg     1980

gcgccaaggt gatcgccacc ggcttcgccg acctgggctt cgacgtggac atcggccccc     2040

tgttccagac cccccgggag gtggcccagc aggccgtgga cgccgacgtg cacgccgtgg     2100

gcgtgagcac cctggccgcc ggccacaaga ccctggtgcc cgagctgatc aaggagctga     2160

acagcctggg ccggcccgac atcctggtga tgtgcggcgg cgtgatcccc ccccaggact     2220

acgagttcct gttcgaggtg ggcgtgagca acgtgttcgg ccccggcacc cggatcccca     2280

aggccgccgt gcaggtgctg gacgacatcg agaagtgcct ggagaagaag cagcagagcg     2340

tgtgataata gtccataaag taggaaacac tacagctgga gcctcggtgg ccatgcttct     2400

tgccccttgg gcctcccccc agcccctcct ccccttcctg cacccgtacc ccccgcatta     2460

ttactcacgg tacgagtggt ctttgaataa agtctgagtg ggcggc                    2506


<210>  767
<211>  2484
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mRNAs encoding human MCM

<400>  767
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatgctgcg ggccaagaac cagctgttcc      120

tgctgagccc ccactacctg cggcaggtga aggagagcag cggcagccgg ctgatccagc      180

agcggctgct gcaccagcag cagcccctgc accccgagtg ggccgccctg gccaagaagc      240

agctgaaggg caagaacccc gaggacctga tctggcacac ccccgagggc atcagcatca      300

agcccctgta cagcaagcgg gacaccatgg acctgcccga ggagctgccc ggcgtgaagc      360

ccttcacccg gggcccctac cccaccatgt acaccttccg gccctggacc atccggcagt      420

acgccggctt cagcaccgtg gaggagagca acaagttcta caaggacaac atcaaggccg      480

gccagcaggg cctgagcgtg gccttcgacc tggccaccca ccggggctac gacagcgaca      540

acccccgggt gcggggcgac gtgggcatgg ccggcgtggc catcgacacc gtggaggaca      600

ccaagatcct gttcgacggc atccccctgg agaagatgag cgtgagcatg accatgaacg      660

gcgccgtgat ccccgtgctg gccaacttca tcgtgaccgg cgaggagcag ggcgtgccca      720

aggagaagct gaccggcacc atccagaacg acatcctgaa ggagttcatg gtgcggaaca      780

cctacatctt cccccccgag cccagcatga agatcatcgc cgacatcttc gagtacaccg      840

ccaagcacat gcccaagttc aacagcatca gcatcagcgg ctaccacatg caggaggccg      900

gcgccgacgc catcctggag ctggcctaca ccctggccga cggcctggag tacagccgga      960

ccggcctgca ggccggcctg accatcgacg agttcgcccc ccggctgagc ttcttctggg     1020

gcatcggcat gaacttctac atggagatcg ccaagatgcg ggccggccgg cggctgtggg     1080

cccacctgat cgagaagatg ttccagccca agaacagcaa gagcctgctg ctgcgggccc     1140

actgccagac cagcggctgg agcctgaccg agcaggaccc ctacaacaac atcgtgcgga     1200

ccgccatcga ggccatggcc gccgtgttcg gcggcaccca gagcctgcac accaacagct     1260

tcgacgaggc cctgggcctg cccaccgtga agagcgcccg gatcgcccgg aacacccaga     1320

tcatcatcca ggaggagagc ggcatcccca aggtggccga cccctggggc ggcagctaca     1380

tgatggagtg cctgaccaac gacgtgtacg acgccgccct gaagctgatc aacgagatcg     1440

aggagatggg cggcatggcc aaggccgtgg ccgagggcat ccccaagctg cggatcgagg     1500

agtgcgccgc ccggcggcag gcccggatcg acagcggcag cgaggtgatc gtgggcgtga     1560

acaagtacca gctggagaag gaggacgccg tggaggtgct ggccatcgac aacaccagcg     1620

tgcggaaccg gcagatcgag aagctgaaga agatcaagag cagccgggac caggccctgg     1680

ccgagcggtg cctggccgcc ctgaccgagt gcgccgccag cggcgacggc aacatcctgg     1740

ccctggccgt ggacgccagc cgggcccggt gcaccgtggg cgagatcacc gacgccctga     1800

agaaggtgtt cggcgagcac aaggccaacg accggatggt gagcggcgcc taccggcagg     1860

agttcggcga gagcaaggag atcaccagcg ccatcaagcg ggtgcacaag ttcatggagc     1920

gggagggccg gcggccccgg ctgctggtgg ccaagatggg ccaggacggc cacgaccggg     1980

gcgccaaggt gatcgccacc ggcttcgccg acctgggctt cgacgtggac atcggccccc     2040

tgttccagac cccccgggag gtggcccagc aggccgtgga cgccgacgtg cacgccgtgg     2100

gcgtgagcac cctggccgcc ggccacaaga ccctggtgcc cgagctgatc aaggagctga     2160

acagcctggg ccggcccgac atcctggtga tgtgcggcgg cgtgatcccc ccccaggact     2220

acgagttcct gttcgaggtg ggcgtgagca acgtgttcgg ccccggcacc cggatcccca     2280

aggccgccgt gcaggtgctg gacgacatcg agaagtgcct ggagaagaag cagcagagcg     2340

tgtgataata ggctggagcc tcggtggcca tgcttcttgc cccttgggcc tccccccagc     2400

ccctcctccc cttcctgcac ccgtaccccc tccataaagt aggaaacact acagtggtct     2460

ttgaataaag tctgagtggg cggc                                            2484


<210>  768
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mRNAs encoding human MCM

<400>  768
atgctgcggg ccaagaacca gctgttcctg ctgagccccc actacctgcg gcaggtgaag       60

gagagcagcg gcagccggct gatccagcag cgcctcctcc accagcagca gcccctccac      120

cccgagtggg ccgccctcgc caagaagcag ctcaagggca agaaccccga ggacctcatc      180

tggcacaccc ccgagggcat ctccatcaag cccctctact ccaagcgcga caccatggac      240

ctccccgagg agctccccgg cgtcaagccc ttcacccgcg gcccctaccc caccatgtac      300

accttccgcc cctggaccat ccgccagtac gccggcttct ccaccgtcga ggagtccaac      360

aagttctaca aggacaacat caaggccggc cagcagggcc tctccgtcgc cttcgacctc      420

gccacccacc gcggctacga ctccgacaac ccccgcgtcc gcggcgacgt cggcatggcc      480

ggcgtcgcca tcgacaccgt cgaggacacc aagatcctct tcgacggcat ccccctcgag      540

aagatgtccg tctccatgac catgaacggc gccgtcatcc ccgtcctcgc caacttcatc      600

gtcaccggcg aggagcaggg cgtccccaag gagaagctca ccggcaccat ccagaacgac      660

atcctcaagg agttcatggt ccgcaacacc tacatcttcc cccccgagcc ctccatgaag      720

atcatcgccg acatcttcga gtacaccgcc aagcacatgc ccaagttcaa ctccatctcc      780

atctccggct accacatgca ggaggccggc gccgacgcca tcctcgagct cgcctacacc      840

ctcgccgacg gcctcgagta ctcccgcacc ggcctccagg ccggcctcac catcgacgag      900

ttcgcccccc gcctctcctt cttctggggc atcggcatga acttctacat ggagatcgcc      960

aagatgcgcg ccggccgccg cctctgggcc cacctcatcg agaagatgtt ccagcccaag     1020

aactccaagt ccctcctcct ccgcgcccac tgccagacct ccggctggtc cctcaccgag     1080

caggacccct acaacaacat cgtccgcacc gccatcgagg ccatggccgc cgtcttcggc     1140

ggcacccagt ccctccacac caactccttc gacgaggccc tcggcctccc caccgtcaag     1200

tccgcccgca tcgcccgcaa cacccagatc atcatccagg aggagtccgg catccccaag     1260

gtcgccgacc cctggggcgg ctcctacatg atggagtgcc tcaccaacga cgtctacgac     1320

gccgccctca agctcatcaa cgagatcgag gagatgggcg gcatggccaa ggccgtcgcc     1380

gagggcatcc ccaagctccg catcgaggag tgcgccgccc gccgccaggc ccgcatcgac     1440

tccggctccg aggtcatcgt cggcgtcaac aagtaccagc tcgagaagga ggacgccgtc     1500

gaggtcctcg ccatcgacaa cacctccgtc cgcaaccgcc agatcgagaa gctcaagaag     1560

atcaagtcct cccgcgacca ggccctcgcc gagcgctgcc tcgccgccct caccgagtgc     1620

gccgcctccg gcgacggcaa catcctcgcc ctcgccgtcg acgcctcccg cgcccgctgc     1680

accgtcggcg agatcaccga cgccctcaag aaggtcttcg gcgagcacaa ggccaacgac     1740

cgcatggtct ccggcgccta ccgccaggag ttcggcgagt ccaaggagat cacctccgcc     1800

atcaagcgcg tccacaagtt catggagcgc gagggccgcc gcccccgcct cctcgtcgcc     1860

aagatgggcc aggacggcca cgaccgcggc gccaaggtca tcgccaccgg cttcgccgac     1920

ctcggcttcg acgtcgacat cggccccctc ttccagaccc cccgcgaggt cgcccagcag     1980

gccgtcgacg ccgacgtcca cgccgtcggc gtctccaccc tcgccgccgg ccacaagacc     2040

ctcgtccccg agctcatcaa ggagctcaac tccctcggcc gccccgacat cctcgtcatg     2100

tgcggcggcg tcatcccccc ccaggactac gagttcctct tcgaggtcgg cgtctccaac     2160

gtcttcggcc ccggcacccg catccccaag gccgccgtcc aggtcctcga cgacatcgag     2220

aagtgcctcg agaagaagca gcagtccgtc                                      2250


<210>  769
<211>  2506
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mRNAs encoding human MCM

<400>  769
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatgctgcg ggccaagaac cagctgttcc      120

tgctgagccc tcactacctg cggcaggtga aggagagcag cggcagccgg ctgatccagc      180

agcggctgct gcaccagcag cagcccctgc accccgagtg ggccgccctg gccaagaagc      240

agctgaaggg caagaacccc gaggacctga tctggcacac gcccgagggc atcagcatca      300

agcccctgta cagcaagcgg gacaccatgg acctgcccga ggagctgccc ggcgtgaagc      360

ccttcacccg gggcccctac cccaccatgt acaccttccg gccctggacc atccggcagt      420

acgccggctt cagcaccgtg gaggagagca acaagttcta caaggacaac atcaaggccg      480

gccagcaggg cctgagcgtg gccttcgacc tggccaccca ccggggctac gacagcgaca      540

acccacgggt gcggggcgac gtgggcatgg ccggcgtggc catcgacacc gtggaggaca      600

ccaagatcct gttcgacggc atccctctgg agaagatgag cgtgagcatg accatgaacg      660

gcgccgtgat ccccgtgctg gccaacttca tcgtgaccgg cgaggagcag ggcgtgccca      720

aggagaagct gaccggcacc atccagaacg acatcctgaa ggagttcatg gtgcggaaca      780

cctacatctt ccctcccgag cccagcatga agatcatcgc cgacatcttc gagtacaccg      840

ccaagcacat gcccaagttc aacagcatca gcatcagcgg ctaccacatg caggaggccg      900

gcgccgacgc catcctggag ctggcctaca ccctggccga cggcctggag tacagccgga      960

ccggcctgca ggccggcctg accatcgacg agttcgcgcc ccggctgagc ttcttctggg     1020

gcatcggcat gaacttctac atggagatcg ccaagatgcg ggccggccgg cggctgtggg     1080

cccacctgat cgagaagatg ttccagccca agaacagcaa gagcctgctg ctgcgggccc     1140

actgccagac cagcggctgg agcctgaccg agcaggaccc ctacaacaac atcgtgcgga     1200

ccgccatcga ggccatggcc gccgtgttcg gcggcaccca gagcctgcac accaacagct     1260

tcgacgaggc cctgggcctg cccaccgtga agagcgcccg gatcgcccgg aacacccaga     1320

tcatcatcca ggaggagagc ggcatcccca aggtggccga cccctggggc ggcagctaca     1380

tgatggagtg cctgaccaac gacgtgtacg acgccgccct gaagctgatc aacgagatcg     1440

aggagatggg cggcatggcc aaggccgtgg ccgagggcat ccccaagctg cggatcgagg     1500

agtgcgccgc ccggcggcag gcccggatcg acagcggcag cgaggtgatc gtgggcgtga     1560

acaagtacca gctggagaag gaggacgccg tggaggtgct ggccatcgac aacaccagcg     1620

tgcggaaccg gcagatcgag aagctgaaga agatcaagag cagccgggac caggccctgg     1680

ccgagcggtg cctggccgcc ctgaccgagt gcgccgccag cggcgacggc aacatcctgg     1740

ccctggccgt ggacgccagc cgggcccggt gcaccgtggg cgagatcacc gacgccctga     1800

agaaggtgtt cggcgagcac aaggccaacg accggatggt gagcggcgcc taccggcagg     1860

agttcggcga gagcaaggag atcaccagcg ccatcaagcg ggtgcacaag ttcatggagc     1920

gggagggccg gcggccccgg ctgctggtgg ccaagatggg ccaggacggc cacgaccggg     1980

gcgccaaggt gatcgccacc ggcttcgccg acctgggctt cgacgtggac atcggcccac     2040

tgttccagac gccccgggag gtggcccagc aggccgtgga cgccgacgtg cacgccgtgg     2100

gcgtgagcac cctggccgcc ggccacaaga ccctggtgcc cgagctgatc aaggagctga     2160

acagcctggg ccggcccgac atcctggtga tgtgcggcgg cgtgatcccg ccccaggact     2220

acgagttcct gttcgaggtg ggcgtgagca acgtgttcgg ccccggcacc cggatcccca     2280

aggccgccgt gcaggtgctg gacgacatcg agaagtgcct ggagaagaag cagcagagcg     2340

tgtgataata gtccataaag taggaaacac tacagctgga gcctcggtgg ccatgcttct     2400

tgccccttgg gcctcccccc agcccctcct ccccttcctg cacccgtacc ccccgcatta     2460

ttactcacgg tacgagtggt ctttgaataa agtctgagtg ggcggc                    2506


<210>  770
<211>  2483
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mRNAs encoding human MCM

<400>  770
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatgctgcg ggccaagaac cagctgttcc      120

tgctgagccc ccactacctg cggcaggtga aggagagcag cggcagccgg ctgatccagc      180

agcgcctcct ccaccagcag cagcccctcc accccgagtg ggccgccctc gccaagaagc      240

agctcaaggg caagaacccc gaggacctca tctggcacac ccccgagggc atctccatca      300

agcccctcta ctccaagcgc gacaccatgg acctccccga ggagctcccc ggcgtcaagc      360

ccttcacccg cggcccctac cccaccatgt acaccttccg cccctggacc atccgccagt      420

acgccggctt ctccaccgtc gaggagtcca acaagttcta caaggacaac atcaaggccg      480

gccagcaggg cctctccgtc gccttcgacc tcgccaccca ccgcggctac gactccgaca      540

acccccgcgt ccgcggcgac gtcggcatgg ccggcgtcgc catcgacacc gtcgaggaca      600

ccaagatcct cttcgacggc atccccctcg agaagatgtc cgtctccatg accatgaacg      660

gcgccgtcat ccccgtcctc gccaacttca tcgtcaccgg cgaggagcag ggcgtcccca      720

aggagaagct caccggcacc atccagaacg acatcctcaa ggagttcatg gtccgcaaca      780

cctacatctt cccccccgag ccctccatga agatcatcgc cgacatcttc gagtacaccg      840

ccaagcacat gcccaagttc aactccatct ccatctccgg ctaccacatg caggaggccg      900

gcgccgacgc catcctcgag ctcgcctaca ccctcgccga cggcctcgag tactcccgca      960

ccggcctcca ggccggcctc accatcgacg agttcgcccc ccgcctctcc ttcttctggg     1020

gcatcggcat gaacttctac atggagatcg ccaagatgcg cgccggccgc cgcctctggg     1080

cccacctcat cgagaagatg ttccagccca agaactccaa gtccctcctc ctccgcgccc     1140

actgccagac ctccggctgg tccctcaccg agcaggaccc ctacaacaac atcgtccgca     1200

ccgccatcga ggccatggcc gccgtcttcg gcggcaccca gtccctccac accaactcct     1260

tcgacgaggc cctcggcctc cccaccgtca agtccgcccg catcgcccgc aacacccaga     1320

tcatcatcca ggaggagtcc ggcatcccca aggtcgccga cccctggggc ggctcctaca     1380

tgatggagtg cctcaccaac gacgtctacg acgccgccct caagctcatc aacgagatcg     1440

aggagatggg cggcatggcc aaggccgtcg ccgagggcat ccccaagctc cgcatcgagg     1500

agtgcgccgc ccgccgccag gcccgcatcg actccggctc cgaggtcatc gtcggcgtca     1560

acaagtacca gctcgagaag gaggacgccg tcgaggtcct cgccatcgac aacacctccg     1620

tccgcaaccg ccagatcgag aagctcaaga agatcaagtc ctcccgcgac caggccctcg     1680

ccgagcgctg cctcgccgcc ctcaccgagt gcgccgcctc cggcgacggc aacatcctcg     1740

ccctcgccgt cgacgcctcc cgcgcccgct gcaccgtcgg cgagatcacc gacgccctca     1800

agaaggtctt cggcgagcac aaggccaacg accgcatggt ctccggcgcc taccgccagg     1860

agttcggcga gtccaaggag atcacctccg ccatcaagcg cgtccacaag ttcatggagc     1920

gcgagggccg ccgcccccgc ctcctcgtcg ccaagatggg ccaggacggc cacgaccgcg     1980

gcgccaaggt catcgccacc ggcttcgccg acctcggctt cgacgtcgac atcggccccc     2040

tcttccagac cccccgcgag gtcgcccagc aggccgtcga cgccgacgtc cacgccgtcg     2100

gcgtctccac cctcgccgcc ggccacaaga ccctcgtccc cgagctcatc aaggagctca     2160

actccctcgg ccgccccgac atcctcgtca tgtgcggcgg cgtcatcccc ccccaggact     2220

acgagttcct cttcgaggtc ggcgtctcca acgtcttcgg ccccggcacc cgcatcccca     2280

aggccgccgt ccaggtcctc gacgacatcg agaagtgcct cgagaagaag cagcagtccg     2340

tctgataata ggctggagcc tcggtggcca tgcttcttgc cccttgggcc tccccccagc     2400

ccctcctccc cttcctgcac ccgtaccccc cgcattatta ctcacggtac gagtggtctt     2460

tgaataaagt ctgagtgggc ggc                                             2483


<210>  771
<211>  2483
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mRNAs encoding human MCM

<400>  771
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatgctgcg ggcgaagaac cagctgttcc      120

tgctaagccc ccactacctg cggcaagtga aggaaagcag cggttcacgg ctgatccagc      180

agcgcctcct ccaccaacag cagcccctcc accccgagtg ggccgccctc gccaagaagc      240

aacttaaagg caagaacccc gaggacctca tttggcacac gcccgagggc atctccatca      300

agcccctcta ctctaagcgc gacaccatgg acctccccga agagctcccc ggcgtcaagc      360

ccttcacccg tggaccctac cctaccatgt acaccttccg cccttggact atccgccagt      420

acgctggctt ttccaccgtc gaggaatcca acaaatttta caaggacaac atcaaagccg      480

gtcaacaagg cctctccgtt gccttcgacc tcgccaccca tcgcggctac gactcggaca      540

acccccgcgt gcgcggcgac gtcggcatgg ccggcgtcgc catcgacacc gtcgaagata      600

ccaagatcct cttcgacggc atcccccttg agaagatgtc cgtctccatg accatgaacg      660

gcgccgtcat ccccgtactc gcaaacttta ttgtcaccgg cgaggagcaa ggcgtgccca      720

aagagaagct cacgggaacc atacagaacg atatcctcaa ggaattcatg gtccgcaata      780

cctacatctt cccacccgag ccctccatga aaatcatcgc cgacatcttc gagtacaccg      840

ccaagcacat gcccaagttc aactcaatct ccatctccgg ctatcatatg caggaggccg      900

gcgccgacgc tatcctcgaa ctcgcttaca ccctggctga cggcctcgag tactcccgca      960

caggcctcca ggcaggcttg acaatcgacg agtttgcccc cagactctct ttcttctggg     1020

gcatcggcat gaacttctac atggagatag ccaaaatgcg cgccggccgc cgcctctggg     1080

cccaccttat tgaaaagatg tttcagccca agaactccaa atccctcctc ctccgtgccc     1140

actgccagac ctcgggttgg tcccttacgg agcaggatcc ctataataac atcgtccgca     1200

ccgccatcga ggctatggcc gcggtcttcg gcggcaccca gtccctccac accaacagtt     1260

tcgacgaggc cctggggctc cccaccgtca aatccgctag gatcgcccgc aacacccaaa     1320

ttattattca ggaagagtcc ggcatcccaa aagtcgccga tccctggggc ggctcctaca     1380

tgatggagtg cctcaccaac gacgtctacg acgccgccct caagctcatc aatgaaatcg     1440

aggagatggg cggcatggcc aaggccgtcg ctgagggcat ccccaagctc cgcatcgagg     1500

agtgcgctgc ccgccgccag gcccggattg actccggttc cgaggtcata gtcggcgtaa     1560

acaagtatca actcgagaag gaagacgctg tcgaggtact cgccatcgac aacaccagtg     1620

tccgaaatcg ccagatagaa aagctcaaga agattaagtc ctcccgcgac caggccctcg     1680

ccgagcgctg cctcgccgcc ctcaccgagt gcgccgcatc cggcgacggc aacattttag     1740

ccctcgccgt cgacgcgtcc cgcgcccgct gcaccgtcgg cgagatcact gacgccctca     1800

agaaggtctt cggggagcac aaggccaacg atcgcatggt ttccggagcc taccgccagg     1860

agttcggaga gagtaaggag attacctctg ccatcaagcg agtccacaag ttcatggaga     1920

gggagggccg ccgcccccgc ctcctcgtcg ccaaaatggg ccaggacggc cacgaccgcg     1980

gcgccaaagt catcgccact ggcttcgccg acctcggatt cgatgtagac attggccccc     2040

tcttccaaac cccccgcgag gtggcccagc aggccgtgga cgccgacgtc cacgccgtcg     2100

gcgtctccac cctcgccgcc ggccacaaga ccctcgtccc cgagctcatt aaggagctca     2160

actccctcgg gcgcccagac atcctcgtca tgtgcggcgg cgtcattccc ccccaggact     2220

acgagttctt attcgaggtc ggcgtcagca acgtcttcgg cccaggaacc cggataccca     2280

aagcggcggt ccaggtcctt gacgatatcg aaaagtgtct cgaaaaaaaa cagcagtccg     2340

tctgataata ggctggagcc tcggtggcca tgcttcttgc cccttgggcc tccccccagc     2400

ccctcctccc cttcctgcac ccgtaccccc cgcattatta ctcacggtac gagtggtctt     2460

tgaataaagt ctgagtgggc ggc                                             2483


<210>  772
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence that encodes an MCM polypeptide with the
       I671V mutation

<400>  772
atgctgcggg cgaagaacca gctgttcctg ctaagccccc actacctgcg gcaagtgaag       60

gaaagcagcg gttcacggct gatccagcag cgcctcctcc accaacagca gcccctccac      120

cccgagtggg ccgccctcgc caagaagcaa cttaaaggca agaaccccga ggacctcatt      180

tggcacacgc ccgagggcat ctccatcaag cccctctact ctaagcgcga caccatggac      240

ctccccgaag agctccccgg cgtcaagccc ttcacccgtg gaccctaccc taccatgtac      300

accttccgcc cttggactat ccgccagtac gctggctttt ccaccgtcga ggaatccaac      360

aaattttaca aggacaacat caaagccggt caacaaggcc tctccgttgc cttcgacctc      420

gccacccatc gcggctacga ctcggacaac ccccgcgtgc gcggcgacgt cggcatggcc      480

ggcgtcgcca tcgacaccgt cgaagatacc aagatcctct tcgacggcat cccccttgag      540

aagatgtccg tctccatgac catgaacggc gccgtcatcc ccgtactcgc aaactttatt      600

gtcaccggcg aggagcaagg cgtgcccaaa gagaagctca cgggaaccat acagaacgat      660

atcctcaagg aattcatggt ccgcaatacc tacatcttcc cacccgagcc ctccatgaaa      720

atcatcgccg acatcttcga gtacaccgcc aagcacatgc ccaagttcaa ctcaatctcc      780

atctccggct atcatatgca ggaggccggc gccgacgcta tcctcgaact cgcttacacc      840

ctggctgacg gcctcgagta ctcccgcaca ggcctccagg caggcttgac aatcgacgag      900

tttgccccca gactctcttt cttctggggc atcggcatga acttctacat ggagatagcc      960

aaaatgcgcg ccggccgccg cctctgggcc caccttattg aaaagatgtt tcagcccaag     1020

aactccaaat ccctcctcct ccgtgcccac tgccagacct cgggttggtc ccttacggag     1080

caggatccct ataataacat cgtccgcacc gccatcgagg ctatggccgc ggtcttcggc     1140

ggcacccagt ccctccacac caacagtttc gacgaggccc tggggctccc caccgtcaaa     1200

tccgctagga tcgcccgcaa cacccaaatt attattcagg aagagtccgg catcccaaaa     1260

gtcgccgatc cctggggcgg ctcctacatg atggagtgcc tcaccaacga cgtctacgac     1320

gccgccctca agctcatcaa tgaaatcgag gagatgggcg gcatggccaa ggccgtcgct     1380

gagggcatcc ccaagctccg catcgaggag tgcgctgccc gccgccaggc ccggattgac     1440

tccggttccg aggtcatagt cggcgtaaac aagtatcaac tcgagaagga agacgctgtc     1500

gaggtactcg ccatcgacaa caccagtgtc cgaaatcgcc agatagaaaa gctcaagaag     1560

attaagtcct cccgcgacca ggccctcgcc gagcgctgcc tcgccgccct caccgagtgc     1620

gccgcatccg gcgacggcaa cattttagcc ctcgccgtcg acgcgtcccg cgcccgctgc     1680

accgtcggcg agatcactga cgccctcaag aaggtcttcg gggagcacaa ggccaacgat     1740

cgcatggttt ccggagccta ccgccaggag ttcggagaga gtaaggagat tacctctgcc     1800

atcaagcgag tccacaagtt catggagagg gagggccgcc gcccccgcct cctcgtcgcc     1860

aaaatgggcc aggacggcca cgaccgcggc gccaaagtca tcgccactgg cttcgccgac     1920

ctcggattcg atgtagacat tggccccctc ttccaaaccc cccgcgaggt ggcccagcag     1980

gccgtggacg ccgacgtcca cgccgtcggc gtctccaccc tcgccgccgg ccacaagacc     2040

ctcgtccccg agctcattaa ggagctcaac tccctcgggc gcccagacat cctcgtcatg     2100

tgcggcggcg tcattccccc ccaggactac gagttcttat tcgaggtcgg cgtcagcaac     2160

gtcttcggcc caggaacccg gatacccaaa gcggcggtcc aggtccttga cgatatcgaa     2220

aagtgtctcg aaaaaaaaca gcagtccgtc                                      2250


<210>  773
<211>  164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3 prime UTR

<400>  773
tgataatagt ccataaagta ggaaacacta cagctggagc ctcggtggcc atgcttcttg       60

ccccttgggc ctccccccag cccctcctcc ccttcctgca cccgtacccc ccgcattatt      120

actcacggta cgagtggtct ttgaataaag tctgagtggg cggc                       164


<210>  774
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3 prime UTR

<400>  774
tgataatagg ctggagcctc ggtggccatg cttcttgccc cttgggcctc cccccagccc       60

ctcctcccct tcctgcaccc gtaccccccg cattattact cacggtacga gtggtctttg      120

aataaagtct gagtgggcgg c                                                141


